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1

10. VIEW OF BUILDINGS 11 (LEFT SIDE) AND 12 (RIGHT ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. VIEW OF BUILDINGS 11 (LEFT SIDE) AND 12 (RIGHT SIDE) FROM SOUTHWEST - Fort Totten, Company Barracks, Building No. 12, 12 miles southwest of Devils Lake City off Route 57, Devils Lake, Ramsey County, ND

2

10,12-Dimethyl-pteridino[6,7-f][1,10]phenanthroline-11,13(10H,12H)-dione-chloro-form (1/1)  

PubMed Central

In the title co-crystal, C18H12N6O2·CHCl3, intra­molecular Cl3C—H?N hydrogen-bonding inter­actions occur between a single CHCl3 and both N atoms at the 1,10-positions on the phenanthroline portion of the mol­ecule. The inter­planar distance between inversion-related mol­ecules is 3.241?(2)?Å.

Olaprath, Waynie; Roden, Jennifer; Wheeler, Kraig A.; McGuire, Mark E.

2010-01-01

3

Molecular phylogenies based on ribosomal protein L11, L1, L10, and L12 sequences  

Microsoft Academic Search

Available sequences that correspond to the E. coli ribosomal proteins L11, L1, L10, and L12 from eubacteria, archaebacteria, and eukaryotes have been aligned. The alignments were analyzed qualitatively for shared structural features and for conservation of deletions or insertions. The alignments were further subjected to quantitative phylogenetic analysis, and the amino acid identity between selected pairs of sequences was calculated.

Daiqing Liao; Patrick P. Dennis

1994-01-01

4

Translocation (10;11)(p12;q23) in childhood acute myeloid leukemia: incidence and complex mechanism.  

PubMed

Using both conventional and molecular cytogenetic methods, we found five new cases of t(10;11)(p12;q23). This translocation represented 28% of all cases of childhood AML treated at our center in 2004, and 63% of AML with rearrangements of 11q23. We describe three mechanisms for the translocation. Different fragments of 11q were involved in four of the five cases. One patient showed a cytogenetically cryptic insertion of 5' part of MLL into the 3' part of MLLT10 in 10p12. The median event-free survival of patients was 8.1 months, and we conclude that the t(10;11)(p12;q23) is associated with unfavorable prognosis in childhood acute myeloid leukemia. PMID:16938568

Stasevich, Irina; Utskevich, Regina; Kustanovich, Anatoly; Litvinko, Natallia; Savitskaya, Tatsiana; Chernyavskaya, Svetlana; Saharova, Olga; Aleinikova, Olga

2006-09-01

5

Translocation (10;11)(p12;q23) in childhood acute myeloid leukemia: incidence and complex mechanism  

Microsoft Academic Search

Using both conventional and molecular cytogenetic methods, we found five new cases of t(10;11)(p12;q23). This translocation represented 28% of all cases of childhood AML treated at our center in 2004, and 63% of AML with rearrangements of 11q23. We describe three mechanisms for the translocation. Different fragments of 11q were involved in four of the five cases. One patient showed

Irina Stasevich; Regina Utskevich; Anatoly Kustanovich; Natallia Litvinko; Tatsiana Savitskaya; Svetlana Chernyavskaya; Olga Saharova; Olga Aleinikova

2006-01-01

6

Strand IV Environmental and Community Health, Ecology and Epidemiology of Health, Grades 10, 11, and 12.  

ERIC Educational Resources Information Center

A frame of reference concerning health implications, based on the interaction of numerous factors in the physical, social, and biological environments, is provided in this prototype curriculum for grades 10-12. Development of sound techniques in problem solving is encouraged, resulting from the need to understand the nature and complexities of…

New York State Education Dept., Albany. Bureau of Secondary Curriculum Development.

7

A Teacher's Guide to Folksinging: A Mini-Elective for Students in Grades 9, 10, 11, and 12.  

ERIC Educational Resources Information Center

To help meet the needs of nonmusic-major students in grade 9, 10, 11, and 12, this teacher's guide offers guidelines for a course to stimulate students' interest and involvement in folksinging. Guidelines are provided on the role of the teacher, methods of instruction, and suggested time allotments. Brief descriptions and comments on some typical…

New York State Education Dept., Albany. Bureau of Secondary Curriculum Development.

8

Caro's Acid–Silica Gel–Catalyzed One-Pot Synthesis of 12Aryl8,9,10,12-tetrahydrobenzo[a] Xanthen-11-ones  

Microsoft Academic Search

The synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a] xanthen-11-ones from aldehyde, ?-naphthol, AND dimedone in the presence of a catalytic amount of Caro's acid–silica gel in good yields under solvent-free conditions is reported.

Narges Karimi; Hossein Abdi Oskooie; Majid M. Heravi; Leila Tahershamsi

2010-01-01

9

The characterization of ficaprenol-10, -11 and -12 from the leaves of Ficus elastica (decorative rubber plant)  

PubMed Central

Evidence from mass, nuclear-magnetic-resonance and infrared spectrometry and from gas–liquid and thin-layer chromatography is presented in favour of the presence of cis–trans-decaprenol, -undecaprenol and -dodecaprenol in the mixture of polyprenols (2·6mg./g.) isolated from leaf tissue of Ficus elastica. The trivial names ficaprenol-10, -11 and -12 are proposed. Nuclear-magnetic-resonance studies showed that each of these prenols contains three trans internal isoprene residues and a cis `OH-terminal' isoprene residue. Ficaprenol-11 is the major component of the mixture. Chromatographic evidence suggests the presence also of small amounts of ficaprenol-9 and -13. The precise position of the three trans internal isoprene residues was not determined but it is suggested that these are adjacent to the ?-terminal isoprene residue and that the ficaprenols are formed from all-trans-geranylgeranyl pyrophosphate. It is also suggested that ficaprenol-10, -11, -12 and -13 are probably the same compounds as castaprenol-10, -11, -12 and -13.

Stone, K. J.; Wellburn, A. R.; Hemming, F. W.; Pennock, J. F.

1967-01-01

10

Iodine-Catalyzed Synthesis of 12Aryl8,9,10,12-tetrahydro-benzo[a]xanthen-11-one Derivatives via Multicomponent Reaction  

Microsoft Academic Search

Iodine efficiently catalyzes the one-pot, three-component reaction of aryl aldehyde, 2-naphthol, and cyclic 1,3-dicarbonyl compound under solvent-free conventional heating conditions to afford the corresponding 12-aryl-8,9,10,12-tetrahydro-benzo[a]xanthen-11-one derivatives. The present approach offers several advantages such as shorter reaction times, good yields, low cost, and mild reaction conditions.

Rui-Zhi Wang; Li-Feng Zhang; Zhen-Shui Cui

2009-01-01

11

Nitriding of low-carbon martensitic stainless steels 03Kh11N10M2T and 03Kh12N10MT  

Microsoft Academic Search

1.The nitrided case on steels 03Kh11N10M2T and 03Kh12N10MT, from the surface to 50–70% of the total case depth, has high corrosion resistance in a humid atmosphere and in salt spray.2.Tempering before nitriding, which ensures a good combination of mechanical properties of the core and the case and high stability of the structure and the dimensions during nitriding and operation, should

L. N. Belyakov; Yu. Yu. Cherkis; G. D. Fomenko; I. P. Zhegina

1977-01-01

12

17 CFR 240.12b-25 - Notification of inability to timely file all or any required portion of a Form 10-K, 20-F, 11-K...  

Code of Federal Regulations, 2010 CFR

...10-K, 20-F, 11-K, N-SAR, N-CSR, 10-Q, or 10-D. 240.12b-25...10-K, 20-F, 11-K, N-SAR, N-CSR, 10-Q, or 10-D. Link to an amendment...annual or transition report on Form N-CSR (17 CFR 249.331; 17 CFR...

2009-04-01

13

17 CFR 240.12b-25 - Notification of inability to timely file all or any required portion of a Form 10-K, 20-F, 11-K...  

Code of Federal Regulations, 2013 CFR

...to timely file all or any required portion of a Form 10-K, 20-F, 11-K, N-SAR, N-CSR, 10-Q, or 10-D. 240.12b-25...to timely file all or any required portion of a Form 10-K, 20-F, 11-K, N-SAR, N-CSR, 10-Q, or...

2013-04-01

14

Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23); MLL-MLLT10  

Microsoft Academic Search

We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as

Zhenjun Lou; Cheng Cheng Zhang; Carlos A. Tirado; Tamara Slone; Junke Zheng; Charles M. Zaremba; Dwight Oliver; Weina Chen

2010-01-01

15

Infantile mixed phenotype acute leukemia (bilineal and biphenotypic) with t(10;11)(p12;q23);MLL-MLLT10.  

PubMed

We report a case of a 6-month-old boy with a mixed phenotype acute leukemia (MPAL), bilineal and biphenotypic immunophenotype (B-lymphoid lineage and combined B-lymphoid and monocytic lineage) with t(10;11)(p12;q23);MLL-MLLT10. He was treated with acute myeloid leukemia protocol and in complete remission at 7-month follow-up. To the best of our knowledge, this is the first reported MLL-MLLT10 rearranged case presenting as MPAL in an infant. From a clinical practice standpoint, this case illustrates the importance of detection of MLL rearrangement due to its prognostic implication and the effectiveness of flow cytometry immunophenotyping in diagnosing MPAL and monitoring minimal residual disease. PMID:20299091

Lou, Zhenjun; Zhang, Cheng Cheng; Tirado, Carlos A; Slone, Tamara; Zheng, Junke; Zaremba, Charles M; Oliver, Dwight; Chen, Weina

2010-08-01

16

Comparison of Postprandial Oleic Acid, 9 c, 11 t CLA and 10 t, 12 c CLA Oxidation in Healthy Moderately Overweight Subjects  

Microsoft Academic Search

Few studies report the individual effect of 9c,11t- and 10t,12c-CLA on human energy metabolism. We compared the postprandial oxidative metabolism of 9c,11t- and 10t,12c-CLA and oleic acid (9c-18:1) in 22 healthy moderately overweight volunteers. After 24 weeks supplementation with 9c,11t-, 10t,12c-CLA or 9c-18:1 (3 g\\/day), subjects consumed a single oral bolus of the appropriate [1-13C]-labeled fatty acid. 8 h post-dose, cumulative oxidation was

Corinne Malpuech-Brugère; Ronald P. Mensink; Olivier Loreau; Agnès Maret; Claire E. Fernie; Taous S. Lassel; Jean Michel Chardigny; Charlie M. Scrimgeour; Jean Louis Sébédio; Bernard Beaufrère

2010-01-01

17

AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12).  

PubMed

Invins(10;11)(p12;q23q12) is one of the rare but recurring chromosome rearrangements seen in acute monoblastic leukemia. We cloned the proximal 10p breakpoint from one patient and showed that the MLL gene at 11q23 was fused to the 3' portion of AF10 at 10p12. In addition, we cloned the telomeric 10p junction and we found that the 5' portion of AF10 was juxtaposed to a previously unidentified gene at 11q12, which we call HEAB (a human homolog to a hypothetical Caenorhabditis elegans ATP/GTP-binding protein). These results indicate that the AF10 gene is split into a 5' AF10 and a 3' AF10 portion by the 11q23q12 chromosome segment and that both breakpoint junctions result in fusion transcripts of 5' AF10/HEAB and MLL/3' AF10. Only the MLL/3' AF10 fusion mRNA results in an in-frame fusion. Northern blot analysis of HEAB expression shows that a 2.0-kb major transcript is expressed ubiquitously in human tissues and is especially abundant in testis and skeletal muscle, whereas a 3.2-kb minor transcript is noted with the highest level of expression in thymus and peripheral blood leukocytes. The HEAB gene encodes a 425-amino acid protein that is rich in valine and leucine. HEAB protein shows high homology in its entire amino acid sequence to a putative C elegans protein and contains an adenosine triphosphate (ATP)/guanosine triphosphate (GTP)-binding motif that has homology to the ATP-binding transporter superfamily or to GTP-binding proteins. Our results could explain the high frequency of complex insertion and other rearrangement events that involve 10p12 and 11q12 and 11q23. The finding that different portions of a single gene are involved in fusions with two independent genes in the same leukemic cell is unique in the analysis of chromosome translocations. PMID:8896421

Tanabe, S; Bohlander, S K; Vignon, C V; Espinosa, R; Zhao, N; Strissel, P L; Zeleznik-Le, N J; Rowley, J D

1996-11-01

18

A Catalytic and Green Procedure for Synthesis of 12Aryl or 12Alkyl8,9,10,12-Tetrahydrobenzo[?]xanthen-11-one Derivatives under Solvent-Free Conditions  

Microsoft Academic Search

An efficient green procedure for the preparation of 12-aryl- or 12-alkyl-8,9,10,12-tetrahydrobenzo[?]xanthen-11-one derivatives, employing three-component one-pot condensation reaction of ?-naphthol, aldehydes, and cyclic 1,3-dicarbonyl compounds, in the presence of Zr(HSO4)4 under solvent-free conditions, has been described. The present protocol offers several advantages such as high yields, shorter reaction time, simple workup, recovery and reusability of catalyst.

Naser Foroughifar; Akbar Mobinikhaledi; Hassan Moghanian

2009-01-01

19

A newly characterized human well-differentiated liposarcoma cell line contains amplifications of the 12q12-21 and 10p11-14 regions.  

PubMed

While surgery is the usual treatment for localized well-differentiated and dedifferentiated liposarcomas (WDLPS/DDLPS), the therapeutic options for patients with advanced disease are limited. The classical antimitotic treatments are most often inefficient. The establishment of genetically characterized cell lines is therefore crucial for providing in vitro models for novel targeted therapies. We have used spectral karyotyping, fluorescence in situ hybridization with whole chromosome painting and locus-specific probes, and array-comparative genomic hybridization to identify the chromosomal and molecular alterations of a novel cell line established from a recurring sclerosing WDLPS. The karyotype was hypertriploid and showed multiple structural anomalies. All cells retained the presence of a giant marker chromosome that had been previously identified in the primary cell cultures. This giant chromosome contained high-level amplification of chromosomal regions 12q13-21 and lacked the alpha-satellite centromeric sequences associated with WDLPS/DDLPS. The 12q amplicon was large, containing 370 amplified genes. The DNA copy number ranged from 3 to 57. The highest levels of amplification were observed at 12q14.3 for GNS, WIF1, and HMGA2. We analyzed the mRNA expression status by real-time reverse transcription polymerase chain reaction for six genes from this amplicon: MDM2, HMGA2, CDK4, TSPAN31, WIF1, and YEATS4. mRNA overexpression was correlated with genomic amplification. A second amplicon originating from 10p11-14 was also present in the giant marker chromosome. The 10p amplicon contained 62 genes, including oncogenes such as MLLT10, previously described in chimeric fusion with MLL in leukemias, NEBL, and BMI1. PMID:22678079

Pedeutour, Florence; Maire, Georges; Pierron, Anne; Thomas, David M; Garsed, Dale W; Bianchini, Laurence; Duranton-Tanneur, Valérie; Cortes-Maurel, Annabelle; Italiano, Antoine; Squire, Jeremy A; Coindre, Jean-Michel

2012-07-01

20

trans-10,cis-12-conjugated linoleic acid isomer exhibits stronger oxyradical scavenging capacity than cis-9,trans-11-conjugated linoleic acid isomer.  

PubMed

Although studies have been performed to test whether conjugated linoleic acid (CLA) acts as an antioxidant, the results were not conclusive. In addition, the CLA widely used in previous research contains 43% cis-9,trans-11 isomer, 45% trans-10,cis-12 isomer, and 10 other minor isomers. The objective of this study was to investigate the antioxidant activity of cis-9,trans-11- and trans-10, cis-12-CLA isomers using high-purity CLA isomers (>98%) by total oxyradical scavenging capacity assay (Winston, G. W.; Regoli, F.; Dugas, Jr., A. J.; Fong, J. H.; Blanchard, K. A. Free Radical Biol. Med. 1998, 24, 480-493). At all concentrations (2-200 microM), t10, c12-CLA performed as an antioxidant with a 15-min lag phase, which was more effective than c9,t11-CLA and alpha-tocopherol at lower concentrations (2 and 20 microM). On the other hand, c9,t11-CLA possessed weak antioxidant activity at 2 and 20 microM, whereas at 200 microM it acted as a strong pro-oxidant, which suggests that discrepancies of the results of the previous studies on the antioxidant properties of CLA may be due to the balance of the antioxidant properties of t10,c12-CLA and the pro-oxidant properties of c9,t11-CLA in different oxidation conditions. PMID:11087504

Leung, Y H; Liu, R H

2000-11-01

21

A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12.  

PubMed

We report the case of an 11-month-old patient with a clinical diagnosis of infantile acute lymphoblastic leukemia and an MLL (11q23) rearrangement in 69% of nuclei, revealed with interphase fluorescence in situ hybridization (FISH). Routine chromosome analysis of the bone marrow showed a very subtle rearrangement involving the short arm of chromosome 10 and the long arm of chromosome 11 in the abnormal cells. To clarify the nature of this rearrangement, we hybridized the MLL break-apart probe to previously G-banded slides. The rearrangement was interpreted as a small inversion within the band 11q23, separating the 5' MLL from the 3' MLL region. This segment on the long arm of chromosome 11 containing the rearranged MLL locus was either inserted in or translocated to the short arm of chromosome 10 at approximately band 10p12. The inversion affecting MLL may have followed insertion or preceded it. Molecular characterization of this rearrangement was not possible, due to limited sample material. There have been previous reports of rearrangements of MLL with the MLLT10 (alias AF10) gene locus at 10p12, including an interstitial inverted insertion of 11q13q23 in one case and insertion of 11q14q23 at 10p12 in another. These both resulted in a large derivative chromosome 10 and transcription of an MLL/MLLT10 fusion product. To our knowledge, the novel and cryptic rearrangement detected in our patient has not been described previously. A follow-up study of the patient's bone marrow at the end of induction therapy showed no morphologic evidence of residual leukemia and both FISH and chromosome analyses were normal. PMID:15381373

Tirado, C A; Lager, J; Rosoff, P M; Golembiski-Ruiz, V; Gong, J Z; Goodman, B K

2004-10-01

22

Studio in Advertising Design, Fashion Design and Illustration, Product Design, Stage Design. Volume 3: Advanced Elective Courses in Art for Grades 10, 11, or 12.  

ERIC Educational Resources Information Center

The document provides teaching guidelines and information on advance elective courses in a studio art program for grades 10, 11, and 12. The courses are presented in four sections: (1) studio in advertising design--advertising and production, lettering, illustrating, and color reproduction; (2) studio in fashion design and illustration--elements…

New York State Education Dept., Albany. Bureau of Secondary Curriculum Development.

23

Ultrasound-Promoted One-Pot Synthesis of 7Aryl7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one Derivatives  

Microsoft Academic Search

A series of 7-aryl-7,10,11,12-tetrahydrobenzo[c]acridin-8(9H)-one derivatives were synthesized via the three-component coupling from aromatic aldehydes, 1-naphthylamine, and 5,5-dimethylcyclohexane-1,3-dione catalyzed by stannous chloride dihydrate (SnCl2 · 2H2O) under ultrasonic irradiation at room temperature. The products were isolated in good yields within short reaction times.

Hongjun Zang; Yong Zhang; Yingming Mo; Bowen Cheng

2011-01-01

24

An investigation of the cosmic radiation in the vicinity of the moon on the Luna 10, 11, and 12 artificial lunar satellites  

NASA Technical Reports Server (NTRS)

Research on the primary cosmic radiation and solar cosmic rays from the Luna 10, 11, and 12 artificial lunar satellites is reviewed. Data on the vertical distribution of cosmic rays above the moon's surface are presented, and the albedo for the primary radiation is determined. The fluxes of electrons with energies from 30 to 300 keV were registered in the solar cosmic rays. Rapid variations of the electron flux were observed. The angular distributions of 0.5-10 MeV protons moving together with the corpuscular streams responsible for Forbush decreases were investigated.

Grigorov, N. L.; Kurt, V. G.; Lutsenko, V. N.; Maduyev, V. L.; Pisarenko, N. F.; Savenko, I. A.

1974-01-01

25

Grades 11- 12 Jacksonian Democracy  

Microsoft Academic Search

This lesson is a social studies lesson for grades 11 and 12 on Jacksonian democracy. Through this lesson students will be able to understand the characteristics of Jacksonian democracy, expanded suffrage, the importance of elected officials, the supremacy of federal over state, and the Indian removal. Students will have an understanding of the positive and negative aspects of this era.

Michael Devlin

2009-01-01

26

Association of IL-12p70 and IL-6:IL-10 ratio with autism-related behaviors in 22q11.2 deletion syndrome: a preliminary report.  

PubMed

22q11.2 deletion syndrome (22q11DS) is a genetic disorder that conveys a significant risk for the development of social behavior disorders, including autism and schizophrenia. Also known as DiGeorge syndrome, 22q11DS is the second most common genetic disorder and is characterized by an elevated risk for immune dysfunction, up to 77% of individuals have an identifiable immune deficiency. We hypothesize that this immune dysfunction could contribute to the elevated risk of impaired social behavior seen in 22q11DS. The current study begins to elucidate these immune deficits and link them with the behavioral alterations associated with the disorder. Serum concentrations of a series of cytokines were examined, using a multiplex immunoassay, in sixteen individuals with 22q11DS and screened for autism-related behavior using the Autism Diagnostic Interview-Revised (ADI-R). This preliminary study examined correlations between specific immune proteins and each of the ADI-R algorithm scores (social, communication, and repetitive behavior). The inflammatory cytokine IL-1?, as well as the ratio between the inflammatory cytokine IL-6 and the anti-inflammatory cytokine IL-10, were correlated with social scores (r=0.851, p=0.004; r=0.580, p=0.018). In addition, the inflammatory cytokines interferon gamma and IL-12p70 were correlated with repetitive behaviors (r=0.795, p=0.033; r=0.774, p=0.002). Interestingly, IL-12 has been reported to be increased in autistic children. These data show a positive association between severity of autism-related behaviors and level of serum concentrations of inflammatory cytokines in individuals with 22q11DS, providing a basis for further inquiry. PMID:23353117

Ross, Heather E; Guo, Ying; Coleman, Karlene; Ousley, Opal; Miller, Andrew H

2013-07-01

27

Postsecondary Institutions and Price of Attendance in the United States: 2010-11, Degrees and Other Awards Conferred: 2009-10, and 12-Month Enrollment: 2009-10. First Look. NCES 2011-250  

ERIC Educational Resources Information Center

This "First Look" presents findings from the Integrated Postsecondary Education Data System (IPEDS) fall 2010 data collection, which included three survey components: Institutional Characteristics for the 2010-11 academic year; Completions, covering the period July 1, 2009, through June 30, 2010; and 12-Month Enrollment, covering 2009-10. This…

Knapp, Laura G.; Kelly-Reid, Janice E.; Ginder, Scott A.

2011-01-01

28

10 CFR 11.11 - General requirements.  

Code of Federal Regulations, 2011 CFR

...FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...Requirements for Special Nuclear Material Access Authorization § 11.11 General...NRC-U special nuclear material access authorization, or by...

2014-01-01

29

A single dose of c9,t11 or t10,c12 conjugated linoleic acid isomers perturbs vitamin A metabolism in mice  

PubMed Central

Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid that has numerous biological activities. Previous studies in rodents demonstrated that chronic intake of CLA t10,c12 or CLA c9,t11 isomers perturbs the metabolism of retinoids (vitamin A and its derivatives). Specifically, while both isomers increased liver retinoid levels, only CLA t10,c12 also stimulated hepatic retinol secretion into the bloodstream. Given that retinoid homeostasis in mammalian serum and tissues is crucial to maintain health, it is important to gain more insights into the mode of action of this nutrient-nutrient interaction. Here we hypothesized that an acute administration of either CLA isomer may also influence vitamin A metabolism. By gavaging wild-type and retinol-binding protein (RBP) knockout mice with an oral bolus of radiolabeled retinol containing one of these two isomers, we showed that both CLA t10,c12 and CLA c9,t11 rapidly enhance hepatic uptake of dietary vitamin A and its re-secretion from the liver in the form of retinol bound to RBP. Indeed, in mice lacking this protein, the sole specific carrier for retinol in the circulation, this latter effect was blunted. Also, by using a pharmacological inhibitor of the clearance of chylomicrons, that distribute recently ingested vitamin A and lipids throughout the body, we provided evidence that CLA intake might rapidly enhance intestinal absorption of dietary vitamin A. These data demonstrate the existence of multiple levels of interaction between dietary CLA and retinoid metabolism and warrant further studies to understand the molecular mechanisms underlying these effects-and their implications for human health.

Giordano, Elena; Banni, Sebastiano; Quadro, Loredana

2011-01-01

30

The Synthesis and Characterization of 1,1-(P(C6H5)3)2-1-H-1,2,4-RhC2B10H12: A Supraicosahedral Metallocarborane Catalyst Precursor.  

National Technical Information Service (NTIS)

The 13-vertex supraicosahedral metallocarborane 1,1-(P(C6H5)3)2-1-H-1,2,4-RhC(2)B(10)H(12), a hydrogenation catalyst precursor, has been synthesized through routes analogous to 10-,11-, and 12-vertex phosphinorhodacarborane formation, and characterized by...

J. D. Hewes C. B. Knobler M. F. Hawthorne

1981-01-01

31

Toxicity of C{sub 10}-, C{sub 11}-, C{sub 12}-, and C{sub 14}-polychlorinated alkanes to Japanese medaka (Oryzias latipes) embryos  

SciTech Connect

Japanese medaka (Oryzias latipes) eggs were exposed to aqueous concentrations of six polychlorinated n-alkane (PCA) standards (C{sub 10}H{sub 15.5}Cl{sub 6.5}, C{sub 10}H{sub 15.3}Cl{sub 6.7}, C{sub 11}H{sub 18.4}Cl{sub 5.6}, C{sub 12}H{sub 19.5}Cl{sub 6.5}, C{sub 14}H{sub 24.9}Cl{sub 5.1}, and C{sub 14}H{sub 23.3}Cl{sub 6.7}) of known carbon chain length and chlorine content to assess their toxicity. Eggs were also exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to act as a positive control. Chlorinated paraffins are complex industrial products for which there is a lack of toxicological data on individual congeners. High aqueous concentrations of C{sub 10}H{sub 15.5}Cl{sub 6.5} and C{sub 10}H{sub 15.3}Cl{sub 6.7} caused 100% mortality in eggs, but no other significant mortalities or lesions were observed at lower concentrations or in any eggs exposed to the other PCAs. Larvae from eggs exposed to high concentrations of the C{sub 10}-, C{sup 11}- and C{sub 12}-PCAs were extremely lethargic or did not move, although a heart beat was present. The concentrations in these exposures and the tissue concentrations of the larvae were at levels that should elicit narcosis. Concentrations of the C{sub 14}-PCAs in larvae did not reach narcotic levels, and larvae in these exposures appeared normal with no signs of narcosis. The TCDD was found to be extremely embryotoxic, consistent with past work using Japanese medaka eggs. The ratio of LC50 to TCDD to the LC50 of the PCAs, based on acute toxicity and TCDD results, were all <0.0001, and most were <0.000001. These results suggest that the acute mechanism of toxicity of lower chlorinated, short (C{sub 10--13}) and medium (C{sub 14--18}) carbon chain PCAs is narcosis and that chlorine substitution on the terminal carbons of PCAs does not significantly increase nor decrease the toxicity of C{sub 10} and C{sub 14}-PCAs. However, additional work is needed to assess a greater range of PCAs as well as their sublethal effects and chronic toxicity.

Fisk, A.T.; Tomy, G.T.; Muir, D.C.G.

1999-12-01

32

Two genetic pathways, t(1;10) and amplification of 3p11-12, in myxoinflammatory fibroblastic sarcoma, haemosiderotic fibrolipomatous tumour, and morphologically similar lesions.  

PubMed

Myxoinflammatory fibroblastic sarcoma (MIFS) is a low-grade malignant neoplasm for which limited genetic information, including a t(1;10)(p22;q24) and amplification of chromosome 3 material, is available. To further characterize these aberrations, we have investigated eight soft tissue sarcomas diagnosed as MIFS, haemosiderotic fibrolipomatous tumour (HFT), myxoid spindle cell/pleomorphic sarcoma with MIFS features, and inflammatory malignant fibrous histiocytoma/undifferentiated pleomorphic sarcoma with prominent inflammation (IMFH) harbouring a t(1;10) or variants thereof and/or ring chromosomes with possible involvement of chromosome 3. Using chromosome banding, fluorescence in situ hybridization, array-based comparative genomic hybridization, global gene expression, and real-time quantitative PCR analyses, we identified the breakpoint regions on chromosomes 1 and 10, demonstrated and delineated the commonly amplified region on chromosome 3, and assessed the consequences of these alterations for gene expression. The breakpoints in the t(1;10) mapped to TGFBR3 in 1p22 and in or near MGEA5 in 10q24, resulting in transcriptional up-regulation of NPM3 and particularly FGF8, two consecutive genes located close to MGEA5. The ring chromosomes contained a commonly amplified 1.44 Mb region in 3p11-12, which was associated with increased expression of VGLL3 and CHMP2B. The identified genetic aberrations were not confined to MIFS; an identical t(1;10) was also found in a case of HFT and the amplicon in 3p was seen in an IMFH. PMID:19199331

Hallor, Karolin H; Sciot, Raf; Staaf, Johan; Heidenblad, Markus; Rydholm, Anders; Bauer, Henrik Cf; Aström, Kristina; Domanski, Henryk A; Meis, Jeanne M; Kindblom, Lars-Gunnar; Panagopoulos, Ioannis; Mandahl, Nils; Mertens, Fredrik

2009-04-01

33

A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12  

Microsoft Academic Search

We report the case of an 11-month-old patient with a clinical diagnosis of infantile acute lymphoblastic leukemia and an MLL (11q23) rearrangement in 69% of nuclei, revealed with interphase fluorescence in situ hybridization (FISH). Routine chromosome analysis of the bone marrow showed a very subtle rearrangement involving the short arm of chromosome 10 and the long arm of chromosome 11

C. A. Tirado; J. Lager; P. M. Rosoff; V. Golembiski-Ruiz; J. Z. Gong; B. K. Goodman

2004-01-01

34

The ?4, ?9, ?10 and ?6+?11 bands of 13CH3-12CH3 between 1245 and 1550 cm-1  

NASA Astrophysics Data System (ADS)

To support atmospheric studies of the Jovian planets, the infrared spectrum of 13CH3-12CH3 was measured between 1245 and 1550 cm-1. Using a 99% 13C-enriched ethane sample, spectra were recorded at 0.0022 cm-1 resolution with the 125 HR Bruker FTIR configured to a temperature-controlled absorption cell of 0.204 m path length cooled to 130.3 K. From these, we obtained the first analysis of isotopic ethane for the three fundamentals (v4, v9 and v10) and one combination band (v6+v11). The spectrum itself is very complex; while torsional splitting produces two components (as in normal ethane), there are additional small splittings in both v9 and v10 wherever the normally infrared inactive v10 levels are perturbed by interaction with nearby states of v9. The spectrum was assigned and analyzed by adopting an appropriate Hamiltonian model; vibration-rotation-torsion parameters of these four bands were determined by the least squares process to model 1348 observed line positions with an RMS deviation of 3.24×10-3 cm-1. The values of rotational and torsional parameters of the vibrational ground state were also improved or determined using the new cold spectrum. The parallel band v4 has very perturbed intensity patterns (e. g. with the R-transitions markedly stronger than the P-transitions) due to its Coriolis coupling with v9, and future analysis of the intensities is needed to obtain reliable predictions of this spectrum. For the interim, an empirical linelist is being formed by combining measured positions and intensities at 130 K with lower state energies from known quantum assignments so that lines of this molecule can be identified in planetary spectra. Part of the research described in this paper was performed at the Jet Propulsion Laboratory, California Institute of Technology, Connecticut College, and NASA Langley under contract with the National Aeronautics and Space Administration.

Brown, Linda R.; di Lauro, C.; Lattanzi, F.; Mantz, A. W.; Smith, M. H.

2013-10-01

35

Structural analysis of lipopolysaccharide produced by Heddleston serovars 10, 11, 12 and 15 and the identification of a new Pasteurella multocida lipopolysaccharide outer core biosynthesis locus, L6.  

PubMed

Pasteurella multocida is a Gram-negative bacterial pathogen classified into 16 serovars based on lipopolysaccharide (LPS) antigens. Previously, we have characterized the LPS outer core biosynthesis loci L1, L2, L3, L5 and L7, and have elucidated the full range of LPS structures associated with each. In this study, we have determined the LPS structures produced by the type strains representing the serovars 10, 11, 12 and 15 and characterized a new LPS outer core biosynthesis locus, L6, common to all. The L6 outer core biosynthesis locus shares significant synteny with the L3 locus but due to nucleotide divergence, gene duplication and gene redundancy, the L6 and L3 LPS outer cores are structurally distinct. Using LPS structural and genetic differences identified in each L6 strain, we have predicted a role for most of the L6 glycosyltransferases in LPS assembly. Importantly, we have identified two glycosyltransferases, GctD and GatB, that differ by one amino acid, A162T, but use different donor sugars [uridine diphosphate (UDP)-Glc and UDP-Gal, respectively]. The longest outer core oligosaccharide, produced by the serovar 12 type strain, contained a terminal region consisting of ?-Gal-(1,4)-?-GlcNAc-(1,3)-?-Gal-(1,4)-?-Glc that was identical in structure to the vertebrate glycosphingolipid, paragloboside. Mimicry of host glycosphingolipids has been observed previously in P. multocida strains belonging to L3 LPS genotype, which produce LPS similar in structure to the globo-series of glycosphingolipids. The expression of a paragloboside-like oligosaccharide on the LPS produced by the serovar 12 type strain indicates that strains belonging to the L6 LPS genotype may also engage in molecular mimicry. PMID:24740556

Harper, Marina; St Michael, Frank; John, Marietta; Steen, Jason; van Dorsten, Lieke; Parnas, Henrietta; Vinogradov, Evgeny; Adler, Ben; Cox, Andrew D; Boyce, John D

2014-07-01

36

Effect of cis-9,trans-11 and trans-10,cis-12 isomers of conjugated linoleic acid on the integrity and functionality of cryopreserved bovine spermatozoa.  

PubMed

Plasma membranes of sperm subjected to low temperatures undergo changes in their structure and permeability. The addition of fatty acids in semen cryopreservation media may influence the sperm motility after thawing, possibly by maintaining the membrane fluidity due to their incorporation in lipid bilayers. In this work, different concentrations of the isomers cis-9,trans-11 and trans-10,cis-12 of conjugated linoleic acid (CLA) were added in the cryopreservation medium of bovine sperm. Four Jersey bulls were used, and the ejaculates were processed as a pool. The Tris-based extender (Dilutris®) was supplemented with 20% egg yolk (MB). The treatments with CLA (Luta-CLA®), which had oily presentation, were prepared from MB with addition of 1% sodium lauryl sulfate, and denominated MBL. The concentrations of CLA tested were 50, 100, and 150 ?M. The motility characteristics of the post-thaw semen were analyzed by computerized analysis system (CASA), and plasma membrane integrity and acrosomal and mitochondrial function assessed by the association of the fluorescent probes propidium iodide, fluorescein isothiocyanate-conjugated Pisum sativum agglutinin (FITC-PSA), JC-1 and Hoechst 33342. No significant differences were observed among treatments, excepting for a decreased mitochondrial potential of cells treated with 150 ?M CLA. The addition of CLA, at the concentrations used, showed no advantages on the integrity and functionality of bovine sperm submitted to cryopreservation. PMID:23721967

Soares, Marcio Pereira; Brandelli, Adriano; Celeghini, Eneiva Carla Carvalho; de Arruda, Rubens Paes; Rodriguez, Shirley Andrea Florez

2013-08-01

37

Fully relativistic rovibrational energies and spectroscopic constants of the lowest X:(1)0(+)g, A':(1)2( u ), A:(1)1 ( u ), B':(1)0(-)u and B:(1)0(+)u states of molecular chlorine.  

PubMed

The main goal of this paper is to present the rovibrational energies and spectroscopic constants of the Cl(2) molecular system in the relativistic states [Formula: see text], A':(1)2( u ), A:(1)1( u ), [Formula: see text] and [Formula: see text]. More precisely, we have evaluated the Cl(2) ? ( e ), ? ( e ) x ( e ), ? ( e ) y ( e ), ? ( e ), ? ( e ) and B ( e ) rovibrational spectroscopic constants using two different procedures. The first was obtained by combining the rovibrational energies, calculated through solving Schrödinger's nuclear equation and the diatomic rovibrational energy equation. The second was obtained by using the Dunham method. The calculated properties are in good agreement with available experimental data. PMID:22581059

Machado, Daniel F S; Silva, Valter H C; Esteves, Cristiano S; Gargano, Ricardo; Macedo, Luiz G M; Mundim, Kleber C; de Oliveira, Heibbe C B

2012-09-01

38

Transcript of Hearings on Condominiums and Cooperatives Held at U. S. Department of the Interior Auditorium, Washington, DC. on February 10, 11, 12, 1975.  

National Technical Information Service (NTIS)

Transcripts relate to hearings held in Washington, D.C., February 10-12, 1975, on the issue of condominiums and cooperatives and, particularly, on the problems, abuses, and potential abuses which have been associated with these forms of housing tenure. Pu...

1975-01-01

39

12 CFR 1301.11 - Administrative appeals.  

Code of Federal Regulations, 2013 CFR

12 Banks and Banking 9 2013-01-01 2013-01-01...11 Section 1301.11 Banks and Banking FINANCIAL STABILITY OVERSIGHT COUNCIL FREEDOM...Information Act Appealâ and addressed to Financial Stability Oversight Council,...

2013-01-01

40

45 CFR 12a.11 - Unsuitable properties.  

Code of Federal Regulations, 2013 CFR

...OF FEDERAL REAL PROPERTY TO ASSIST THE HOMELESS § 12a.11 Unsuitable properties...of properties determined unsuitable for homeless assistance. HUD will inform landholding...determination is filed by a representative of the homeless pursuant to § 12a.4(f)(4)....

2013-10-01

41

10. SAME DETAIL AS ABOVE, WITH SHUTTER FULLY CLOSED 11. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. SAME DETAIL AS ABOVE, WITH SHUTTER FULLY CLOSED 11. 'SHIP ROOM,' SECOND FLOOR, LOOKING NORTHWEST 12. 'SHIP ROOM,' SECOND FLOOR, LOOKING NORTH - Friends Meeting House, 30 Farewell Street, Newport, Newport County, RI

42

Ticket to Tomorrow: The National Legislative Conference on Small Business Issues (11th). Held in Atlanta, Georgia on December 10-12, 1990.  

National Technical Information Service (NTIS)

The 11th conference focuses on small business challenges in the 1990s and beyond. A number of social and demographic trends will affect America's business community in the next decade, among them, the shrinking work force, increasing international competi...

1990-01-01

43

Reaction of [Os 3(CO) 10(MeCN) 2] with 2,3-bis(2-pyridyl)pyrazine and pyrazyne. Synthesis, characterization and electrochemical behavior of 1:1 and 1:2 ligand:cluster complexes  

Microsoft Academic Search

The diimine-bridged, bis-triosmium carbonyl complexes [{Os3(CO)10(?-H)}2(pyz)] 1b, [{Os3(CO)10}2(dpp)] 2b, (pyz=pyrazine; dpp=2,3-bis(2-pyridyl)pyrazine) and their corresponding 1:1 ligand:cluster complexes [Os3(CO)10(?-H)(pyz)], 1a, [Os3(CO)10(dpp)], 2a, were synthesized by the reaction of [Os3(CO)10(MeCN)2] with pyz and dpp ligands. All compounds were characterized by IR, 1H-NMR spectroscopy and elemental analysis. Electrochemistry was used to examine the redox properties of 1–2 and of complexes [Os3(CO)10(?-H)(py)], 3, for

Ricardo M de Souza; Fernanda Martins; Edison Stein

1998-01-01

44

Acute exposure of L6 myotubes to cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid isomers stimulates glucose uptake by modulating Ca2+/calmodulin-dependent protein kinase II.  

PubMed

Conjugated linoleic acid (CLA), a dietary fat, has been considered beneficial in metabolic syndrome. Despite several findings indicating that CLA improves glucose clearance, little information is available regarding the cellular dynamics of CLA on skeletal muscle. We sought to investigate the role of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in cis-9, trans-11(c9,t11) and trans-10, cis-12 (t10,c12) CLA isomer-mediated glucose transport by L6 myotubes. t10,c12-CLA stimulated both intracellular Ca(2+) release (Ca(i)(2+)) and CaMKII phosphorylation, whereas c9,t11-CLA showed only modest effects on both. Sequestering Ca(i)(2+) with BAPTA/AM abrogated the effect of both CLA isomers on Akt substrate-160 kDa (AS160) phosphorylation and glucose uptake by myotubes. Exposing myotubes to KN-93 or autocamtide 2-related inhibitory peptide to block CaMKII activity prevented both CLA isomers from inducing AS160 phosphorylation and glucose transport. Likewise, genetic knockdown of CaMKII in myotubes using siRNA completely abolished CLA isomer-mediated glucose uptake. These results indicate that CLA isomers require Ca(i)(2+)-CaMKII to mediate glucose uptake. Evidence that CaMKII blockers inhibit t10,c12-CLA-mediated AMP-activated protein kinase (AMPK) activation indicated that CaMKII acts upstream of AMPK in response to t10,c12-CLA. Lastly, CLA isomers stimulated the formation of reactive oxygen species but had no effect on stress-activated protein kinase/c-jun NH(2)-terminal kinase. These data establish that t10,c12-CLA acts via Ca(i)(2+)-CaMKII-AMPK-AS160 to stimulate skeletal muscle glucose transport, whereas the mechanism of c9,t11-CLA remains unclear. Given that impairments in muscle glucose utilisation are apparent in metabolic syndrome, delineating the molecular mechanisms by which CLA isomers mediate muscle glucose uptake may identify new approaches to manage this condition. PMID:22609102

Mohankumar, Suresh K; Taylor, Carla G; Siemens, Linda; Zahradka, Peter

2012-08-01

45

10-(4-Chloro-phen-yl)-14a-hy-droxy-12-methyl-8,9,9a,10,12,13,14,14a-octa-hydro-5H-10a,14-methano-indeno-[2',1':4,5]azepino[3,4-b]pyrrolizine-5,15(7H,11H)-dione.  

PubMed

The asymmetric unit of the title compound, C26H25ClN2O3, contains two independent mol-ecules (A and B). The conformation of the two mol-ecules differs essentially in the dihedral angle involving the two benzene rings. They are inclined to one another by 52.47?(10) in A and by 31.75?(11)° in B. In both mol-ecules, the six-membered piperidin-3-one rings have chair conformations. In mol-ecule A, all four five-membered rings have twist conformations. In mol-ecule B, only three of the four five-membered rings have twist conformations. The fourth, of the inden-1-one moiety, has an envelope conformation with the spiro C atom, bonded to the N atom of the pyrrolidine ring, as the flap. A weak intra-molecular O-H?N hydrogen bond occurs in each independent mol-ecule while a C-H?O inter-action is also observed in mol-ecule A. In the crystal, pairs of O-H?O hydrogen bonds link the mol-ecules, forming inversion dimers with graph-set motif R 2 (2)(12). These dimers are further inter-connected by C-H?O and C-H?? inter-actions, forming a three-dimensional network. PMID:24527024

Nagalakshmi, R A; Suresh, J; Malathi, K; Kumar, R Ranjith; Lakshman, P L Nilantha

2014-01-01

46

10-(4-Chloro-phen-yl)-14a-hy-droxy-12-methyl-8,9,9a,10,12,13,14,14a-octa-hydro-5H-10a,14-methano-indeno-[2?,1?:4,5]azepino[3,4-b]pyrrolizine-5,15(7H,11H)-dione  

PubMed Central

The asymmetric unit of the title compound, C26H25ClN2O3, contains two independent mol­ecules (A and B). The conformation of the two mol­ecules differs essentially in the dihedral angle involving the two benzene rings. They are inclined to one another by 52.47?(10) in A and by 31.75?(11)° in B. In both mol­ecules, the six-membered piperidin-3-one rings have chair conformations. In mol­ecule A, all four five-membered rings have twist conformations. In mol­ecule B, only three of the four five-membered rings have twist conformations. The fourth, of the inden-1-one moiety, has an envelope conformation with the spiro C atom, bonded to the N atom of the pyrrolidine ring, as the flap. A weak intra­molecular O—H?N hydrogen bond occurs in each independent mol­ecule while a C—H?O inter­action is also observed in mol­ecule A. In the crystal, pairs of O—H?O hydrogen bonds link the mol­ecules, forming inversion dimers with graph-set motif R 2 2(12). These dimers are further inter­connected by C—H?O and C—H?? inter­actions, forming a three-dimensional network.

Nagalakshmi, R.A.; Suresh, J.; Malathi, K.; Kumar, R. Ranjith; Lakshman, P. L. Nilantha

2014-01-01

47

Effects of poloxamer 407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats: Impact of decreased expression of both CYP3A1/2 and microsomal epoxide hydrolase.  

PubMed

The pharmacokinetics of carbamazepine (CBZ) and its active 10,11-epoxide metabolite (CBZ-E) were evaluated after intravenous and oral administration of 5 mg/kg CBZ to rats with hyperlipidemia induced by poloxamer 407 (HL rats) and controls. The total area under the plasma concentration-time curve (AUC) of CBZ in HL rats after intravenous administration was significantly greater than that in controls due to their slower non-renal clearance (CL(NR)). This was due to slower hepatic CL(int) for metabolism of CBZ to CBZ-E in HL rats via CYP3A1/2. This result was consistent with a previous study indicating reduced hepatic CYP3A1/2 expression in HL rats. Interestingly, the AUC of CBZ-E was also increased in HL rats, while AUC(CBZ-E)/AUC(CBZ) ratios remained unchanged. These results suggested that further metabolism of CBZ-E to the inactive metabolite trans-10,11-dihydoxyl-10,11-dihydro-CBZ (CBZ-D) via microsomal epoxide hydrolase (mEH) was also slowed in HL rats. The significantly reduced hepatic mRNA level and expression of mEH protein in HL rats compared to controls confirmed the above hypothesis. Similar pharmacokinetic changes were observed in HL rats after oral administration of CBZ. These findings have potential therapeutic implications assuming that the HL rat model qualitatively reflects similar changes in patients with hyperlipidemia. Caution is required regarding pharmacotherapy in the hyperlipidemic state in cases where drugs that are metabolized principally by CYP3A1/2 or mEH and have a narrow therapeutic range are in use. PMID:22137858

Lee, Young Sun; Kim, Young Woo; Kim, Sang Geon; Lee, Inchul; Lee, Myung Gull; Kang, Hee Eun

2012-06-01

48

43 CFR 11.12 - Biennial review of regulations.  

Code of Federal Regulations, 2013 CFR

...11.12 Section 11.12 Public Lands: Interior Office of the Secretary of the Interior NATURAL RESOURCE DAMAGE ASSESSMENTS Introduction § 11.12 Biennial review of regulations. The regulations and procedures included within...

2013-10-01

49

Electrochemical behavior of a macrocyclic diimine crown ether: 2,3,11,12-dibenzo-5,9-diaza-4,9(10)-cis-diimino-1,13-dioxacyclopentadecane  

Microsoft Academic Search

A macrocyclic diimine crown ether, 2,3,11,12-dibenzo-5,9-diaza-4,9(10)-cis-diimino-1,13-dioxacyclopentadecane (O-en-N-tn), was synthesized and its electrochemical behavior reported. Reduction of ?C?N? bonds was studied in an ethyl alcohol + water mixture (1:5 v\\/v) using sampled current polarographic, differential pulse polarographic, cyclic voltammetric, chronoamperometric and chronocoulometric techniques. A mechanism for the electrode reaction was proposed. The diffusion coefficient, heterogeneous rate constant and transfer coefficient of

A. Osman Solak; Selahattin Yilmaz; Zeynel Kiliç

1996-01-01

50

An Environmental Syllabus: Grades 10, 11, 12.  

ERIC Educational Resources Information Center

This syllabus is intended as a multi-purpose syllabus for environmental studies in the senior high school. Some units, or parts of units, are appropriate for use in the junior high school. The units in this syllabus are: (1) The Environmental Status Quo; (2) Natural Environments; (3) Food and People; (4) Population Dynamics; (5) Energy, Part I and…

Jamason, Barry W.

51

Pioneers 10 and 11 deep space missions  

NASA Technical Reports Server (NTRS)

Pioneers 10 and 11 were launched from Earth, 2 March 1972, and 5 April 1973, respectively. The Pioneers were the first spacecraft to explore the asteroid belt and the first to encounter the giant planets, Jupiter and Saturn. The Pioneer 10 spacecraft is now the most distant man-made object in our solar system and is farther from the Sun than all nine planets. It is 47 AU from the Sun and is moving in a direction opposite to that of the Sun's motion through the galaxy. Pioneer 11 is 28 AU from the Sun and is traveling in the direction opposite of Pioneer 10, in the same direction as the Sun moves in the galaxy. These two Pioneer spacecraft provided the first large-scale, in-situ measurements of the gas and dust surrounding a star, the Sun. Since launch, the Pioneers have measured large-scale properties of the heliosphere during more than one complete 11-year solar sunspot cycle, and have measured the properties of the expanding solar atmosphere, the transport of cosmic rays into the heliosphere, and the high-energy trapped radiation belts and magnetic fields associated with the planets Jupiter and Saturn. Accurate Doppler tracking of these spin-stabilized spacecraft was used to search for differential gravitational forces from a possible trans-Neptunian planet and to search for gravitational radiation. Future objectives of the Pioneer 10 and 11 missions are to continue measuring the large-scale properties of the heliosphere and to search for its boundary with interstellar space.

Dyal, Palmer

1990-01-01

52

Oxidative Aromatization, Cytotoxic Activity Evaluation and Conformational Study of Novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione Derivatives.  

PubMed Central

In the present work, novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione derivatives were synthesized by oxidation of 7-aryl-8, 9, 10, 12-tetrahydro-7H-chromeno[4, 3-b]quinoline-6, 8-diones in the presence of silica sulfuric acid/NaNO2 with yields of 64-74%. Cytotoxic activity of synthesized compounds was assessed on three different human cancer cell lines (K562, LS180, and MCF-7). Synthesized compounds showed moderate cytotoxic activities. The most active one apeared to be 2e, containing a methoxy group on the meta position of phenyl ring (IC50 range in different cell lines: 11.1–55.7 µM). Furthermore; comparison of the cytotoxic activity of these novel oxidized derivatives with non-oxidized counterparts revealed that oxidation of dihydropyridine ring to pyridine, improves the activity especially in LS180 cell line. Conformational analysis revealed that some conformational aspects of oxidized derivatives such as orientation of C7-aryl substitute were clearly different from non-oxidized ones.

Motamedi, Radineh; Shafiee, Abbas; Rezai, Mohammad Reza; Firuzi, Omidreza; Edraki, Najmeh; Miri, Ramin

2014-01-01

53

Oxidative Aromatization, Cytotoxic Activity Evaluation and Conformational Study of Novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione Derivatives.  

PubMed

In the present work, novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione derivatives were synthesized by oxidation of 7-aryl-8, 9, 10, 12-tetrahydro-7H-chromeno[4, 3-b]quinoline-6, 8-diones in the presence of silica sulfuric acid/NaNO2 with yields of 64-74%. Cytotoxic activity of synthesized compounds was assessed on three different human cancer cell lines (K562, LS180, and MCF-7). Synthesized compounds showed moderate cytotoxic activities. The most active one apeared to be 2e, containing a methoxy group on the meta position of phenyl ring (IC50 range in different cell lines: 11.1-55.7 µM). Furthermore; comparison of the cytotoxic activity of these novel oxidized derivatives with non-oxidized counterparts revealed that oxidation of dihydropyridine ring to pyridine, improves the activity especially in LS180 cell line. Conformational analysis revealed that some conformational aspects of oxidized derivatives such as orientation of C7-aryl substitute were clearly different from non-oxidized ones. PMID:24734061

Motamedi, Radineh; Shafiee, Abbas; Rezai, Mohammad Reza; Firuzi, Omidreza; Edraki, Najmeh; Miri, Ramin

2014-01-01

54

Crystal structure, detonation performance, and thermal stability of a new polynitro cage compound: 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptacyclo [5.5.1.1(3, 11).1 (5, 9)] pentadecane.  

PubMed

A new polynitro cage compound 2, 4, 6, 8, 10, 12, 13, 14, 15-nonanitro-2, 4, 6, 8, 10, 12, 13, 14, 15-nonaazaheptcyclo [5.5.1.1(3,11).1(5,9)] pentadecane (NNNAHP) was designed in the present work. Its molecular structure was optimized at the B3LYP/6-31 G(d,p) level of density functional theory (DFT) and crystal structure was predicted using the Compass and Dreiding force fields and refined by DFT GGA-RPBE method. The obtained crystal structure of NNNAHP belongs to the P-1 space group and the lattice parameters are a = 9.99 Å, b = 10.78 Å, c = 9.99 Å, ? = 90.01°, ? = 120.01°, ? = 90.00°, and Z = 2, respectively. Based on the optimized crystal structure, the band gap, density of state, thermodynamic properties, infrared spectrum, strain energy, detonation characteristics, and thermal stability were predicted. Calculation results show that NNNAHP has detonation properties close to those of CL-20 and is a high energy density compound with moderate stability. PMID:21989962

Zhang, Jian-ying; Du, Hong-chen; Wang, Fang; Gong, Xue-dong; Ying, San-jiu

2012-06-01

55

Lavoisierite, Mn2+ 8[Al10(Mn3+Mg)][Si11P]O44(OH)12, a new mineral from Piedmont, Italy: the link between "ardennite" and sursassite  

NASA Astrophysics Data System (ADS)

The new mineral species lavoisierite, ideally Mn2+ 8[Al10(Mn3+Mg)][Si11P]O44(OH)12, has been discovered in piemontite-bearing micaschists belonging to the Piedmontese Nappe from Punta Gensane, Viù Valley, Western Alps, Italy. It occurs as yellow-orange acicular to prismatic-tabular crystals up to a few millimeters in length, with white streak and vitreous luster, elongated along [010] and flattened on {001}. Lavoisierite is associated with quartz, "mica," sursassite, piemontite, spessartine, braunite, and "tourmaline." Calculated density is 3.576 g cm-3. In plane-polarized light, it is transparent, pleochroic, with pale yellow parallel to [010] and yellow-orange normal to this direction; extinction is parallel and elongation is positive. Birefringence is moderate; the calculated average refraction index n is 1.750. Lavoisierite is orthorhombic, space group Pnmm, with a 8.6891(10), b 5.7755(3), c 36.9504(20) Å, V 1854.3(2) Å3, Z = 2. Calculated main diffraction lines of the X-ray powder diffraction pattern are [ d in Å, ( I), ( hkl); relative intensities are visually estimated]: 4.62 (m) (112), 2.931 (vs) (11 10), 2.765 (s) (11 11), 2.598 (s) (310), 2.448 (ms) (028). Chemical analyses by electron microprobe give (in wt%) P2O5 2.08, V2O5 0.37, SiO2 34.81, TiO2 0.13, Al2O3 22.92, Cr2O3 0.32, Fe2O3 0.86, Mn2O3 6.92, MnO 19.09, MgO 5.73, CaO 1.94, Na2O 0.01, H2O 5.44, sum 100.62 wt%. H2O content was calculated from structure refinement. The empirical formula, based on 56 anions, is (Mn{5.340/2+}Mg1.810Ca0.686Na0.006)?=7.852(Al8.921Mn{1.739/3+}Mg1.010Fe{0.214/3+}Cr0.084Ti0.032)?=12.000(Si11.496P0.582V0.081)?=12.159O43.995(OH)12.005. The crystal structure of lavoisierite was solved by direct methods and refined on the basis of 1743 observed reflections to R 1 = 4.6 %. The structure is characterized by columns of edge-sharing octahedra running along [010] and linked to each other by means of [SiO4], [Si2O7], and [Si3O10] groups. Lavoisierite, named after the French chemist and biologist Antoine-Laurent de Lavoisier (1743-1794), displays an unprecedented kind of structure, related to those of "ardennite" and sursassite.

Orlandi, Paolo; Biagioni, Cristian; Pasero, Marco; Mellini, Marcello

2013-03-01

56

Syntheses, structures and photoluminescence properties of a series of metal–organic complexes with 1,3-benzenedicarboxylate and 10,11,12,13-tetrahydro-4,5,9,14-tetraaza-benzo[b]triphenylene ligands  

Microsoft Academic Search

Three unusual compounds that a one-dimensional (1-D) chain and two two-dimensional (2-D) sheets are synthesized by the combination of three different metallic salts and organic ligands that 10,11,12,13-tetrahydro-4,5,9,14-tetraaza-benzo[b]triphenylene (TTBT) and 1,3-benzenedicarboxylic acid (1,3-H2BDC), viz. [Cd(TTBT)(1,3-BDC)]n (1), [Mn2(TTBT)2(1,3-BDC)2]n (2) and [Zn2(TTBT)2(1,3-BDC)2]n·2nH2O (3), characterized by elemental analyses, thermal gravimetry (TG), fluorescent emission and single crystal X-ray diffraction analyses. 1 has a square-wave-like

Guangbo Che; Jian Wang; Chunbo Liu; Xiuying Li; Bo Liu; Jun Sun; Yang Liu; Lu Lu

2009-01-01

57

Magnetic field reversal of electric polarization and magnetoelectric phase diagram of the hexaferrite Ba1.3Sr0.7Co0.9Zn1.1Fe10.8Al1.2O22  

NASA Astrophysics Data System (ADS)

Low magnetic field reversal of electric polarization has been demonstrated in the multiferroic Y-type hexaferrite Ba1.3Sr0.7Co0.9Zn1.1Fe10.8Al1.2O22 single crystal. The maximum magnetoelectric coefficient at 200 K reaches 1065 ps/m near zero magnetic field. By a systematic investigation of magnetic field dependence of magnetic and dielectric responses at various temperatures, we obtained the magnetoelectric phase diagram describing the detailed evolution of the spin-induced ferroelectric phases with temperature and magnetic field. Below 225 K, the transverse spin cone can be stabilized at zero magnetic field, which is responsible for the reversal behavior of electric polarization. Our study reveals how to eventually achieve magnetic field reversal of electric polarization in hexaferrites at room temperature.

Shen, Shipeng; Yan, Liqin; Chai, Yisheng; Cong, Junzhuang; Sun, Young

2014-01-01

58

A germanosilicate structure with 11×11×12-ring channels solved by electron crystallography.  

PubMed

Zeolites have been widely used in industry owing to their ordered micropores and stable frameworks. The pore sizes and shapes are the key parameters that affect the selectivity and efficiency in their applications in catalysis, sorption, and separation. Zeolites with pores defined by 10 and 12 TO4 tetrahedra are often used for various catalytic processes. To optimize the performance of zeolites, it is extremely desirable to fine-tune the pore sizes/shapes. The first germanosilicate zeolite with a three-dimensional 11×11×12-ring channel system, PKU-16 (PKU, Peking University) is presented. Nanosized PKU-16 was structurally characterized by the new three-dimensional rotation electron diffraction (RED) technique. PKU-16 is structurally related to the zeolite ??polymorph?C (BEC, 12×12×12-ring channels) by rotating half of the four-rings in double mtw units. PMID:24719362

Hua, Wei; Chen, Hong; Yu, Zheng-Bao; Zou, Xiaodong; Lin, Jianhua; Sun, Junliang

2014-06-01

59

Effects of cis-9,trans-11 and trans-10,cis-12 Conjugated Linoleic Acid, Linoleic Acid, Phytanic Acid and the Combination of Various Fatty Acids on Proliferation and Cytokine Expression of Bovine Peripheral Blood Mononuclear Cells  

PubMed Central

Fatty acids may have an impact on immune functions, which is important in times of increased mobilization of body fat, e.g., around parturition. The aim of the present study was to investigate the effects of the CLA isomers cis-9,trans-11 and trans-10,cis-12, phytanic acid (PA), linoleic acid (LA) and a fatty acid (FA) mixture (containing 29.8% palmitic acid, 6.7% palmitoleic acid, 17.4% stearic acid and 46.1% oleic acid) on the proliferation of bovine blood mononuclear cells (PBMC) in vitro using alamar blue (AB) and 5-bromo-2?-deoxyuridine (BrdU) assay. Quantitative real time polymerase chain reaction analyses were performed to evaluate the expression of interleukin (IL)-4, IL-10, interferon (IFN)-?, tumor necrosis factor (TNF)-? and peroxisome proliferator-activated receptor (PPAR)-? in response to cis-9,trans-11 and LA. The IC50 values did not differ between the investigated FA, but there were differences within the proliferation in the response of these FA in a concentration range between 20 and 148 µM (e.g., increased proliferation after treatment with lower concentrations of LA). No differences occurred when different FA combinations were tested. ConA stimulation increased the expression of TNF-? and IFN-?, whereas IL-10 decreased. In general, neither the baseline expression nor the ConA-stimulated mRNA expression of cytokines and PPAR-? were affected by the FA. In conclusion, all FA inhibit the proliferation of PBMC dose dependently without significantly altering the induced cytokine spectrum of activated bovine PBMC.

Renner, Lydia; Kersten, Susanne; Duevel, Anna; Schuberth, Hans-Joachim; Danicke, Sven

2013-01-01

60

Wavelength measurements of heliumlike 1s2s 3S1-1s2p 3P0,2 transitions in Ne8+, Na9+, Mg10+, and Si12+ emitted by solar flare plasmas  

NASA Astrophysics Data System (ADS)

With the Solar Ultraviolet Measurements of Emitted Radiation instrument-a high-resolution normal-incidence telescope and spectrometer on board the Solar and Heliospheric Observatory-heliumlike 1s2s 3S1-1s2p 3P0,2 transitions in the highly ionized species Ne8+, Na9+, Mg10+, and Si12+ were observed. The spectral lines were emitted by high-temperature solar flare plasmas. In this paper, we report on wavelength measurements of the He-like lines identified in the recorded spectra. The wavelength uncertainties we obtained from the solar measurements are <=20 mÅ(1?), and in one case <=30 mÅ. This is comparable to or better than the best determinations so far achieved for these heliumlike 1s2s 3S1-1s2p 3P0,2 transitions with instrumentation in the laboratory. For the Na9+ 3S1-3P2 transition we report what is to our knowledge the first wavelength measurement. The knowledge of the accurate wavelengths can provide important checks on atomic structure calculations.

Curdt, W.; Landi, E.; Wilhelm, K.; Feldman, U.

2000-08-01

61

12 CFR 1402.11 - Current index.  

Code of Federal Regulations, 2013 CFR

...11 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION RELEASING...Availability of Records of the Farm Credit System Insurance Corporation § 1402.11 Current index. The Farm Credit System Insurance Corporation...

2013-01-01

62

(2R*,4R*,7S*,10R*,12R*)-3,11,13,15-Tetra-oxa-penta-cyclo-[5.5.3.01,7.02,4.010,12]penta-deca-5,8-dien-14-one  

PubMed Central

The title compound, C11H8O5, features a ‘skipped’ diene, an anti-bis­(epoxide) and a cyclic carbonate, all embedded in a densely functionalized [4.4.3]propellane scaffold. The crystal packing of this diepoxide is effected primarily by C—H?O hydrogen bonds, which link the mol­ecules into tapes along the b axis. Inter-tape connectivity is brought about by centrosymmetrically disposed pairs of C?O contacts [3.183?(4)?Å] between the C?+=O?- dipoles of neighbouring carbonate moieties.

Mehta, Goverdhan; Sen, Saikat; Kumar, C. S. Ananda

2013-01-01

63

Molecular motions involved in Na-K-Cl cotransporter-mediated ion transport and transporter activation revealed by internal cross-linking between transmembrane domains 10 and 11/12.  

PubMed

We examined the relationship between transmembrane domain (TM) 10 and TM11/12 in NKCC1, testing homology models based on the structure of AdiC in the same transporter superfamily. We hypothesized that introduced cysteine pairs would be close enough for disulfide formation and would alter transport function: indeed, evidence for cross-link formation with low micromolar concentrations of copper phenanthroline or iodine was found in 3 of 8 initially tested pairs and in 1 of 26 additionally tested pairs. Inhibition of transport was observed with copper phenanthroline and iodine treatment of P676C/A734C and I677C/A734C, consistent with the proximity of these residues and with movement of TM10 during the occlusion step of ion transport. We also found Cu(2+) inhibition of the single-cysteine mutant A675C, suggesting that this residue and Met(382) of TM3 are involved in a Cu(2+)-binding site. Surprisingly, cross-linking of P676C/I730C was found to prevent rapid deactivation of the transporter while not affecting the dephosphorylation rate, thus uncoupling the phosphorylation and activation steps. Consistent with this, (a) cross-linking of P676C/I730C was dependent on activation state, and (b) mutants lacking the phosphoregulatory domain could still be activated by cross-linking. These results suggest a model of NKCC activation that involves movement of TM12 relative to TM10, which is likely tied to movement of the large C terminus, a process somehow triggered by phosphorylation of the regulatory domain in the N terminus. PMID:24451383

Monette, Michelle Y; Somasekharan, Suma; Forbush, Biff

2014-03-14

64

10 CFR 11.30 - Violations.  

Code of Federal Regulations, 2011 CFR

...Section 11.30 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL Violations § 11.30 Violations. (a) The Commission may obtain an...

2014-01-01

65

10 CFR 11.9 - Specific exemptions.  

Code of Federal Regulations, 2013 CFR

...Section 11.9 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL General Provisions § 11.9 Specific exemptions. The...

2014-01-01

66

10 CFR 11.3 - Scope.  

Code of Federal Regulations, 2011 CFR

...DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...11 or § 11.13 requiring access to, or control over, formula quantities...criteria, or procedures for access to or control over classified special...

2014-01-01

67

10 CFR 11.32 - Criminal penalties.  

Code of Federal Regulations, 2012 CFR

...Section 11.32 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL Violations § 11.32 Criminal penalties. (a) Section 223 of...

2014-01-01

68

12 CFR 1403.11 - Criminal penalties.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Criminal penalties. 1403.11 Section 1403.11 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION PRIVACY ACT REGULATIONS § 1403.11 Criminal penalties. Section 552a(i)(3)...

2013-01-01

69

Pioneer 10 and 11 Data Analysis  

NASA Technical Reports Server (NTRS)

This report finishes the work of NASA Grant NAS2-153, which supported data analysis for the UCSD instruments on Pioneers 10 and 11. The data analyzed under this grant span 22 years of interplanetary measurements in the inner and outer heliosphere. The UCSD instruments made their mark in cosmic ray research based upon their high energy thresholds, directional responses, and reliable data streams. one of their primary scientific objectives concerns the size, configuration, and time behavior of the heliosphere. The size scale is inferred from the radial intensity gradient, which is measured between the two spacecraft and extrapolated to interstellar intensity levels at the cosmic ray modulation boundary. This boundary still eludes us, and its position, motion, and the best method of extrapolation are ongoing problems. Current projections place the boundary beyond 100 AU, which may be beyond the termination shock, and raises the question of possible modulation in the heliosheath. Probably our only hope of seeing this region in the immediate future rides on the possibility that the boundary will move inward. Our instruments have recorded many Forbush, or transient, decreases in the outer heliosphere. These observations led us to a model that attributes many of the decreases to solar wind stream-stream interactions, and relates the cosmic ray variations to the locally observed magnetic field magnitude. As the cosmic ray variations in this model result only from topological changes in the modulation integral, the model is a tool for studying the possibility that the 11 year cosmic ray modulation cycle can be accounted for by a superposition of Forbush decreases. The cosmic ray angular distribution function is measurable, given a good telemetry rate, by the UCSD Cerenkov detector which counts particles of energy greater than 500 MeV/n. We obtained statistically significant samples from 1 to 9 AU, at 13 AU, and at 34 AU. The anisotropy tends to be a few tenths of a per cent at all radial distances. A quasiperiodic variation in the east-west anisotropy with period of about 50 days remains unexplained.

Fillius, Walker

1997-01-01

70

19 CFR 11.12b - Labeling textile fiber products.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 2013-04-01 false Labeling textile fiber products. 11.12b Section 11.12b...STAMPING; MARKING Marking § 11.12b Labeling textile fiber products. (a) Textile fiber products imported into the United...

2013-04-01

71

tert-Butyl (2R,4aR,5aR,11aS,12R,12aR)-8-[bis-(tert-but-oxycarbon-yl)amino]-12-hydroxy-2-meth-oxy-2,10-dioxo-4,4a,5a,6,9,10,11,11a,12,12a-deca-hydro-2H-1,3,5-trioxa-6,7,9,11-tetra-aza-2?5-phosphatetra-cene-6-carboxyl-ate methanol monosolvate monohydrate  

PubMed Central

The title compound, C26H40N5O13P·CH3OH·H2O, crystallizes with one water and one methanol mol­ecule providing important crystal-binding inter­actions. The compound has the unusual feature of having two but­oxy­carbonyl groups bound to one N atom. The conventional attractive hydrogen bonds involving hy­droxy, amine and water donors include bifurcations at both donors and acceptors with novel R 1 2(6) and R 2 1(6) motifs. These are supplemented by C—H?O inter­actions between adjacent mol­ecules forming chain and R 2 2(10) ring motifs.

Gainsford, Graeme J.; Clinch, Keith; Dixon, Rachel; Tiwari, Ashish

2012-01-01

72

46 CFR 188.10-11 - Chemistry laboratory.  

Code of Federal Regulations, 2012 CFR

... Shipping 7 2012-10-01 2012-10-01 false Chemistry laboratory. 188.10-11 Section 188.10-11 Shipping...Definition of Terms Used in This Subchapter § 188.10-11 Chemistry laboratory. This term includes any space in which...

2012-10-01

73

46 CFR 188.10-11 - Chemistry laboratory.  

Code of Federal Regulations, 2013 CFR

... Shipping 7 2013-10-01 2013-10-01 false Chemistry laboratory. 188.10-11 Section 188.10-11 Shipping...Definition of Terms Used in This Subchapter § 188.10-11 Chemistry laboratory. This term includes any space in which...

2013-10-01

74

10 CFR 81.11 - Policy.  

...STANDARD SPECIFICATIONS FOR THE GRANTING OF PATENT LICENSES Nrc-Owned Inventions-Patents and Applications § 81.11 Policy. (a) The inventions covered by the U.S. patents and patent applications vested in...

2014-01-01

75

Synthesis, crystal chemistry, and magnetic properties of RE7Li8Ge10 and RE11Li12Ge16 (RE = La-Nd, Sm): new members of the [REGe2](n)[RELi2Ge](m) homologous series.  

PubMed

Eight new rare-earth metal-lithium-germanides belonging to the [REGe(2)](n)[RELi(2)Ge](m) homologous series have been synthesized and structurally characterized by single-crystal X-ray diffraction. The structures of the title compounds can be rationalized as linear intergrowths of imaginary RELi(2)Ge (MgAl(2)Cu structure type) and REGe(2) (AlB(2) structure type) slabs. The compounds with general formula RE(7)Li(8)Ge(10) (RE = La-Nd, Sm), i.e., [REGe(2)](3)[RELi(2)Ge](4), crystallize in the orthorhombic space group Cmmm (No. 65) with a new structure type. Similarly, the compounds with general formula RE(11)Li(12)Ge(16) (RE = Ce-Nd), i.e., [REGe(2)](5)[RELi(2)Ge](6), crystallize in the orthorhombic space group Immm (No. 71) also with its own structure type. Temperature-dependent DC magnetization measurements indicate Curie-Weiss paramagnetism in the high-temperature regime and hint at complex magnetic ordering at low temperatures. The measured effective moments are consistent with RE(3+) ground states in all cases. The experimental results have been complemented by tight-binding linear muffin-tin orbital (TB-LMTO) electronic structure calculations. PMID:22663087

Guo, Sheng-Ping; You, Tae-Soo; Jung, Ya-Ho; Bobev, Svilen

2012-06-18

76

Two solvatomorphic forms of a copper complex formulated as Cu(L(1))(ClO4)2·1.2H2O and Cu(L(1))(ClO4)2, where L(1) is 3,10-C-meso-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradecane.  

PubMed

Two copper complex solvatomorphs, namely (3,10-C-meso-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradecane)bis(perchlorato-?O)copper(II) 1.2-hydrate, [Cu(ClO4)2(C18H40N4)]·1.2H2O, (I), and (3,10-C-meso-3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradecane)bis(perchlorato-?O)copper(II), [Cu(ClO4)2(C18H40N4)], (II), are described and compared with each other and with a third, already reported, anhydrous diastereomer, denoted (III). Both compounds present very similar centrosymmetic coordination environments, with the Cu(II) cation lying on an inversion centre in a distorted 4+2 octahedral environment, defined by the macrocyclic N4 group in the equatorial sites and two perchlorate groups in trans-axial positions [one of the perchlorate ligands in (I) is partially disordered]. The most significant difference in molecular shape is seen in the orientation of the perchlorate anions, and the influence of this on the intramolecular hydrogen bonding is discussed. The (partially) hydrated state of (I) favours the formation of chains along [011], while the anhydrous character of (II) and (III) promotes loosely bound structures with low packing indices. PMID:23832023

Nath, Babul Chandra; Suarez, Sebastián; Doctorovich, Fabio; Roy, Tapashi G; Baggio, Ricardo

2013-07-01

77

Topological BPS charges in 10- and 11-dimensional supergravity  

SciTech Connect

We consider the supersymmetry algebras of the maximal supergravities in 10 and 11 dimensions. We construct expressions from which the topological charge structure of the algebras can be determined in supersymmetric curved backgrounds. These are interpreted as the topological charges of the 1/2-BPS states that are found in the theories. We consider charges for all the M-, NS- and D-branes as well as the Kaluza-Klein monopoles. We also show that the dimensional reduction relations between the 11-dimensional and IIA charges, and T-duality relations of the IIA and IIB charges, match those found for the branes themselves. Finally we consider the massive versions of the IIA and 11-dimensional theories and find that the expressions for the charges, with a slight modification, are still valid in those instances.

Callister, Andrew K.; Smith, Douglas J. [Department of Mathematical Sciences, Durham University, Science Laboratories, South Road, Durham. DH1 3LE (United Kingdom)

2008-09-15

78

44 CFR 12.11 - Public notice.  

Code of Federal Regulations, 2013 CFR

...MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES...procedure described by § 12.6 of this part for the creation of the advisory committee, and...contrarily for reasons of national security, timely notice of each...

2013-10-01

79

43 CFR 10.12 - Civil penalties.  

Code of Federal Regulations, 2013 CFR

...Objects, or Objects of Cultural Patrimony in Museums and Federal Collections § 10.12 ...the Act to assess civil penalties on any museum that fails to comply with the requirements...failure to comply.â (1) Your museum has failed to comply with the...

2013-10-01

80

Auto Mechanics: Grades 10-12.  

ERIC Educational Resources Information Center

A collection of 185 objectives and related test items for students studying auto mechanics in grades 10 through 12 is provided. Auto tune-up and repair skills are emphasized. The objectives are divided into two sections: objectives calling for demonstrations of the processes, and objectives requiring written responses. Most objectives contain…

Instructional Objectives Exchange, Los Angeles, CA.

81

Chemistry of Metalloborane Derivatives Containing the B10H12 Ligand.  

National Technical Information Service (NTIS)

Ligand displacement reactions of (B10H12)Pd(PPh3)2 were used to prepare ((B10H12)Pd(CN2))(2-), ((B10H12)Pd(C2S2(CN)2))(-2), and (B10H12)Pd(1,10-C10H8N2). The reaction of the latter phenanthroline complex with butyllithium produced (((B10H11)Pd)2C10H8N2)(-...

A. R. Siedle L. J. Todd

1976-01-01

82

12 CFR 1229.11 - Capital restoration plans.  

Code of Federal Regulations, 2012 CFR

12 Banks and Banking 9 2012-01-01 2012-01-01...plans. 1229.11 Section 1229.11 Banks and Banking FEDERAL HOUSING FINANCE AGENCY...PROMPT CORRECTIVE ACTION Federal Home Loan Banks § 1229.11 Capital restoration...

2012-01-01

83

10. Historic American Buildings Survey Alex Bush, Photographer, December 11, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey Alex Bush, Photographer, December 11, 1936 MANTEL ON NORTH WALL OF SOUTH EAST REAR ROOM, GROUND FLOOR - Lakewood, U.S. Highway 11 (Washington Street), Livingston, Sumter County, AL

84

An efficient and selective flourescent optode membrane based on 7-[(5-chloro-8-hydroxy-7-quinolinyl)methyl]-5,6,7,8,9,10-hexahydro-2H-1,13,4,7,10-benzodioxatriazacyclopentadecine-3,11(4H,12H)-dione as a novel fluoroionophore for determination of cobalt(II) ions.  

PubMed

A novel fluorescence chemical sensor for the highly sensitive and selective determination of Co(2+) ions in aqueous solutions is prepared. The cobalt sensing system was prepared by incorporating 7-[(5-chloro-8-hydroxy-7-quinolinyl)methyl]-5,6,7,8,9,10-hexahydro-2H-1,13,4,7,10-benzodioxatriazacyclopentadecine-3,11(4H,12H)-dione (L) as a neutral cobalt-selective fluoroionophore in the plasticized PVC membrane containing sodium tetraphenylborate as a liphophilic anionic additive. The response of the sensor is based on the strong selective fluorescence quenching of L by Co(2+) ions. At a pH 5.0, the proposed sensor displays a calibration curve over a wide concentration range of 5.0 x 10(-7) to 2.0 x 10(-2)M with a relatively fast response time of less than 5 min. In addition to high stability and reproducibility, the sensor shows a unique selectivity towards Co(2+) ion with respect to common coexisting cations. The proposed fluorescence optode was successfully applied to the determination of cobalt content of vitamin B12 ampoule, cobalt cake, cobalt alloy and tap water samples. PMID:19068326

Shamsipur, Mojtaba; Sadeghi, Marzieh; Alizadeh, Kamal; Sharghi, Hashem; Khalifeh, Reza

2008-12-01

85

Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia  

Microsoft Academic Search

The MLL gene, located on chromosomal band 11q23, is fused to a large number of different partner genes in hematological malignancies. This report describes a case of infant acute biphenotypic leukemia with t(1;15;11;10)(p36;q11;q23;q24). Panhandle polymerase chain reaction (PCR) using cDNA demonstrated the formation of an MLL–MLLT10 fusion transcript, although the 10p12 segment, at which the MLLT10 gene is located, was

Kazuyuki Matsuda; Miyuki Tanaka; Sachiko Araki; Ryu Yanagisawa; Kazuyoshi Yamauchi; Kenichi Koike

2009-01-01

86

47 CFR 10.11 - CMAS implementation timeline.  

Code of Federal Regulations, 2010 CFR

...COMMUNICATIONS COMMISSION GENERAL COMMERCIAL MOBILE ALERT SYSTEM General Information § 10.11 CMAS implementation...later than 10 months from the date that the Federal Alert Aggregator and Alert Gateway makes the Government Interface Design...

2010-10-01

87

47 CFR 10.11 - CMAS implementation timeline.  

Code of Federal Regulations, 2012 CFR

...COMMUNICATIONS COMMISSION GENERAL COMMERCIAL MOBILE ALERT SYSTEM General Information § 10.11 CMAS implementation...later than 10 months from the date that the Federal Alert Aggregator and Alert Gateway makes the Government Interface Design...

2012-10-01

88

47 CFR 10.11 - CMAS implementation timeline.  

Code of Federal Regulations, 2011 CFR

...COMMUNICATIONS COMMISSION GENERAL COMMERCIAL MOBILE ALERT SYSTEM General Information § 10.11 CMAS implementation...later than 10 months from the date that the Federal Alert Aggregator and Alert Gateway makes the Government Interface Design...

2011-10-01

89

47 CFR 10.11 - WEA implementation timeline.  

Code of Federal Regulations, 2013 CFR

...COMMUNICATIONS COMMISSION GENERAL WIRELESS EMERGENCY ALERTS General Information § 10.11 WEA implementation...later than 10 months from the date that the Federal Alert Aggregator and Alert Gateway makes the Government Interface Design...

2013-10-01

90

11. Historic drawing, Pier 10. Plan of deck and pilings, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Historic drawing, Pier 10. Plan of deck and pilings, 1932. Photographic copy of original. Boston National Historical Park Archives, Charlestown Navy Yard. - Charlestown Navy Yard, Pier 10, Between Piers 9 & 11 along Mystic River on Charlestown Waterfront at eastern edge of Charlestown Navy Yard, Boston, Suffolk County, MA

91

130. FORWARD AND STARBOARD VIEW BETWEEN APOLLO 11 AND 12 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

130. FORWARD AND STARBOARD VIEW BETWEEN APOLLO 11 AND 12 RECOVERIES, SHOWING FINAL CONFIGURATION BEFORE INACTIVATION. 30 OCTOBER 1969. (NATIONAL ARCHIVES NO. 428-KN-18315) - U.S.S. HORNET, Puget Sound Naval Shipyard, Sinclair Inlet, Bremerton, Kitsap County, WA

92

12. Historic view, Pier 11. View to north, showing concrete ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic view, Pier 11. View to north, showing concrete pier under construction, 1956. Photographic copy of photo. Boston National Historical Park Archives, Charlestown Navy Yard. - Charlestown Navy Yard, Pier 11, Charlestown Waterfront at confluence of Little Mystic Channel & Mystic River at northernmost ent of Navy Yard, Boston, Suffolk County, MA

93

12 CFR 1281.11 - Bank housing goals.  

Code of Federal Regulations, 2013 CFR

12 Banks and Banking 9 2013-01-01 2013-01-01 false Bank housing goals. 1281.11 Section 1281.11 Banks and Banking FEDERAL HOUSING FINANCE AGENCY HOUSING GOALS AND MISSION FEDERAL HOME LOAN BANK HOUSING GOALS...

2013-01-01

94

12 CFR 1281.11 - Bank housing goals.  

Code of Federal Regulations, 2012 CFR

12 Banks and Banking 9 2012-01-01 2012-01-01 false Bank housing goals. 1281.11 Section 1281.11 Banks and Banking FEDERAL HOUSING FINANCE AGENCY HOUSING GOALS AND MISSION FEDERAL HOME LOAN BANK HOUSING GOALS...

2012-01-01

95

10 CFR 470.12 - Management.  

Code of Federal Regulations, 2010 CFR

...470.12 Section 470.12 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION APPROPRIATE TECHNOLOGY SMALL GRANTS...Office of the Assistant Secretary for Conservation and Solar Energy of DOE. (b) The program shall be implemented...

2010-01-01

96

10 CFR 609.12 - Project Costs.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Project Costs. 609.12 Section 609.12...INNOVATIVE TECHNOLOGIES § 609.12 Project Costs. (a) Before entering into...DOE shall determine the estimated Project Costs for the project that is...

2011-01-01

97

10 CFR 609.12 - Project Costs.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Project Costs. 609.12 Section 609.12...INNOVATIVE TECHNOLOGIES § 609.12 Project Costs. (a) Before entering into...DOE shall determine the estimated Project Costs for the project that is...

2012-01-01

98

10 CFR 609.12 - Project Costs.  

...2014-01-01 2014-01-01 false Project Costs. 609.12 Section 609.12...INNOVATIVE TECHNOLOGIES § 609.12 Project Costs. (a) Before entering into...DOE shall determine the estimated Project Costs for the project that is...

2014-01-01

99

10 CFR 609.12 - Project Costs.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Project Costs. 609.12 Section 609.12...INNOVATIVE TECHNOLOGIES § 609.12 Project Costs. (a) Before entering into...DOE shall determine the estimated Project Costs for the project that is...

2013-01-01

100

10 CFR 609.12 - Project Costs.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Project Costs. 609.12 Section 609.12...INNOVATIVE TECHNOLOGIES § 609.12 Project Costs. (a) Before entering into...DOE shall determine the estimated Project Costs for the project that is...

2010-01-01

101

10 CFR 609.12 - Project costs.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 2009-01-01 false Project costs. 609.12 Section 609.12...INNOVATIVE TECHNOLOGIES § 609.12 Project costs. (a) Before entering into...DOE shall determine the estimated Project Costs for the project that is...

2009-01-01

102

Molecular cytogenetic analysis of 10;11 rearrangements in acute myeloid leukemia.  

PubMed

MLLT10 (previously called AF10) is a moderately common MLL fusion partner predominantly occurring in acute monoblastic leukemia (AML-M5). 10;11 rearrangements require at least three breaks in order to generate an in-frame MLL-MLLT10 fusion as a result of the opposite orientations of both genes on the respective chromosome arms. In this study, we describe a detailed molecular cytogenetic analysis of MLL-MLLT10 positive 10;11 rearrangements in two patients. We observed an as yet unreported chromosomal mechanism with at least four breakpoints, leading to MLL-MLLT10 gene fusion in a 24-year-old male. An inversion of 11q13-q23 with a breakpoint in the MLL gene was followed by an additional break 3' of MLL prior to insertion of the 11q segment into MLLT10. In a second patient, a 37-year-old male with AML-M5b, molecular cytogenetic analysis of an apparent 10;11 reciprocal translocation showed an intrachromosomal inversion of 3'MLLT10followed by a reciprocal translocation between 10p12 and 11q23. Review of the literature showed that all cases were the result of an inversion of either 10p or 11q followed by translocation 10p;11q or insertion of the inverted segment into MLLT10 or MLL. PMID:11896537

Van Limbergen, H; Poppe, B; Janssens, A; De Bock, R; De Paepe, A; Noens, L; Speleman, F

2002-03-01

103

10. Historic view, Pier 11. Aerial view to east, 1943. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic view, Pier 11. Aerial view to east, 1943. Photographic copy of photo. Boston National Historical Park Archives, Charlestown Navy Yard. - Charlestown Navy Yard, Pier 11, Charlestown Waterfront at confluence of Little Mystic Channel & Mystic River at northernmost ent of Navy Yard, Boston, Suffolk County, MA

104

Sedimentology of Apollo 11 and 12 lunar soils.  

NASA Technical Reports Server (NTRS)

Differences in the modal composition of samples from an Apollo 11 core tube (10005) suggest the presence of at least three depositional units. The double-drive-tube core sample from the Apollo 12 site shows evidence of at least 16 depositional episodes. The earliest recognizable event at the Apollo 12 site carried light-colored soil rich in feldspathic-rock fragments into the area and may be related to ejection of ray material from Copernicus. Prior to the formation of Surveyor Crater at least 11 depositional episodes took place. Unit 7-8, the thickest unit intersected by the core tube, is tentatively identified as the Surveyor Crater ejecta blanket. Most of the soil at the Apollo 11 and 12 sites was probably generated locally with a smaller contribution coming from a more distant source possibly in the lunar highlands.

Lindsay, J. F.

1971-01-01

105

The 10,11B(n, p) 10,11Be reactions at E n =96 MeV  

Microsoft Academic Search

Double-differential cross sections of the 10,11B(n,p)10,11Be reactions have been measured at 96 MeV in the angular range 0°–30° for excitation energies up to 35 MeV. The spectra have been decomposed into different multipolarities using sample angular distributions calculated within the distorted-wave Born approximation. From the identified Gamow–Teller strength, S?+ values were obtained for 10B and 11B. At higher excitation energies,

A Ringbom; J Blomgren; H Condé; K Elmgren; N Olsson; J Rahm; T Rönnqvist; O Jonsson; L Nilsson; P.-U Renberg; G Tibell; Chr Bargholtz; K Fransson; K Lindh; P.-E Tegnér; P Thörngren Engblom; S. Y van der Werf

2001-01-01

106

A novel modified carbon paste electrode based on NiO/CNTs nanocomposite and (9, 10-dihydro-9, 10-ethanoanthracene-11, 12-dicarboximido)-4-ethylbenzene-1, 2-diol as a mediator for simultaneous determination of cysteamine, nicotinamide adenine dinucleotide and folic acid.  

PubMed

A carbon paste electrode (CPE) modified with (9, 10-dihydro-9, 10-ethanoanthracene-11, 12-dicarboximido)-4-ethylbenzene-1, 2-diol (DEDE) and NiO/CNTs nanocomposite was used for the sensitive voltammetric determination of cysteamine (CA), nicotinamide adenine dinucleotide (NADH) and folic acid (FA) for the first time. The synthesized materials were characterized with different methods such as XRD, cyclic voltammetry, electrochemical impedance spectroscopy (EIS) and square wave voltammetry (SWV). The modified electrode exhibited a potent and persistent electron mediating behavior followed by well-separated oxidation peaks of CA, NADH and FA. The peak currents were linearly dependent on CA, NADH and FA concentrations using square wave voltammetry (SWV) method in the ranges of 0.01-250, 1.0-500, and 3.0-550 µmol L?¹, with detection limits of 0.007, 0.6, and 0.9 µmol L?¹, respectively. The modified electrode was used for the determination of CA, NADH and FA in biological and pharmaceutical samples. PMID:23707873

Karimi-Maleh, Hassan; Biparva, Pourya; Hatami, Mehdi

2013-10-15

107

12 CFR 1408.10 - Review procedures.  

Code of Federal Regulations, 2013 CFR

...10 Section 1408.10 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION COLLECTION OF CLAIMS OWED THE...the supervision or control of the Chairman of the Farm Credit System Insurance Corporation. (d) The Corporation...

2013-01-01

108

6. Historic view, Pier 9, 10, 11. Aerial Views to ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. Historic view, Pier 9, 10, 11. Aerial Views to east, 1943. Photographic copy of photo. Boston National Historical Park Archives, Charlestown Navy Yard. - Charlestown Navy Yard, Pier 9, Between Piers 8 & 10, along Mystic River on Charlestown Waterfront at eastern edge of Navy Yard, Boston, Suffolk County, MA

109

Australian Chemistry Test Item Bank: Years 11 & 12. Volume 1.  

ERIC Educational Resources Information Center

Volume 1 of the Australian Chemistry Test Item Bank, consisting of two volumes, contains nearly 2000 multiple-choice items related to the chemistry taught in Year 11 and Year 12 courses in Australia. Items which were written during 1979 and 1980 were initially published in the "ACER Chemistry Test Item Collection" and in the "ACER Chemistry Test…

Commons, C., Ed.; Martin, P., Ed.

110

Italian, Grades 11, 12, and 13. Curriculum S.15D.  

ERIC Educational Resources Information Center

GRADES OR AGES: Grades 11, 12, and 13. SUBJECT MATTER: Italian. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is divided into five main sections: Preamble, Course Content, Reading Program, Vocabulary Topics, and Reference. Each section is in list form. The guide is offset printed and staple-bound with a paper cover. OBJECTIVES AND ACTIVITIES:…

Ontario Dept. of Education, Toronto.

111

Cluster Structure of {sup 12}C and {sup 11}Be  

SciTech Connect

The structure of {sup 12}C is discussed, in particular the spectrum of states above the alpha-decay threshold. A search for the 2{sup +} excitation of the Hoyle-state is reported. The structural link between halo-like states and molecular states is explored in the case of {sup 11}Be.

Freer, M.; Haigh, P. J.; Ashwood, N. I.; Bloxham, T.; Curtis, N.; McEwan, P. [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham, B15 2TT (United Kingdom); Fujita, H.; Carter, J.; Usman, I. [School of Physics, University of the Witwatersrand, Johannesburg 2050 (South Africa); Buthelezi, Z.; Foertsch, S. V.; Neveling, R.; Perez, S. M.; Smit, F. D. [iThemba LABS, PO Box 722, Somerset West 7129 (South Africa); Fearick, R. W. [Physics Department, University of Cape Town, Rondebosch 7700 (South Africa); Papka, P.; Swartz, J. A. [Physics Department, University of Stellenbosch, Stellenbosch (South Africa); Bohlen, H. G.; Dorsch, T.; Kokalova, Tz. [Helmholtz-Zentrum Berlin, Glienicker Strasse 100, D-14109 Berlin (Germany)

2009-08-26

112

CSE Secondary School Test Evaluations: Grades 11 and 12.  

ERIC Educational Resources Information Center

Over 1,100 published tests including over 5,400 subtests, keyed to educational objectives of secondary education, were evaluated by measurement experts and educators. The tests were evaluated specifically with the concerns of grades 11 and 12 in mind. Upon a test's or subtest's assignment to one of the educational objectives, it was subjected to…

Hoepfner, Ralph, Ed.; And Others

113

Cosmic Optical Background: the view from Pioneer 10/11  

NASA Astrophysics Data System (ADS)

We present the new constraints on the cosmic optical background (COB) obtained from an analysis of the Pioneer 10/11 Imaging Photopolarimeter (IPP) data. After careful examination of data quality, the usable measurements free from the zodiacal light are integrated into sky maps at the blue (~0.44 ?m) and red (~0.64 ?m) bands. Accurate starlight subtraction is achieved by referring to all-sky star catalogs and a Galactic stellar population synthesis model down to 32.0 mag. We find that the residual light is separated into two components: one component shows a clear correlation with thermal 100 ?m brightness, while another betrays a constant level in the lowest 100 ?m brightness region. Presence of the second component is significant after all the uncertainties and possible residual light in the Galaxy are taken into account, thus it most likely has the extragalactic origin (i.e., the COB). The derived COB brightness is (1.8 +/- 0.9) × 10-9 and (1.2 +/- 0.9) × 10-9 erg s-1 cm-2 sr-1 Å-1 at the blue and red band, respectively, or 7.9 +/- 4.0 and 7.7 +/- 5.8 nW m-2 sr-1. Based on a comparison with the integrated brightness of galaxies, we conclude that the bulk of the COB is comprised of normal galaxies which have already been resolved by the current deepest observations. There seems to be little room for contributions of other populations including ``first stars'' at these wavelengths. On the other hand, the first component of the IPP residual light represents the diffuse Galactic light (DGL)--scattered starlight by the interstellar dust. We derive the mean DGL-to-100 ?m brightness ratios of 2.1 × 10-3 and 4.6 × 10-3 at the two bands, which are roughly consistent with the previous observations toward denser dust regions. Extended red emission in the diffuse interstellar medium is also confirmed.

Matsuoka, Y.; Ienaka, N.; Kawara, K.; Oyabu, S.

2012-08-01

114

Cosmic Optical Background: The View from Pioneer 10/11  

NASA Astrophysics Data System (ADS)

We present the new constraints on the cosmic optical background (COB) obtained from an analysis of the Pioneer 10/11 Imaging Photopolarimeter (IPP) data. After careful examination of data quality, the usable measurements free from the zodiacal light are integrated into sky maps at the blue (~0.44 ?m) and red (~0.64 ?m) band. Accurate starlight subtraction is achieved by referring to all-sky star catalogs and a Galactic stellar population synthesis model down to 32.0 mag. We find that the residual light is separated into two components: one component shows a clear correlation with thermal 100 ?m brightness, while another betrays a constant level in the lowest 100 ?m brightness region. The presence of the second component is significant after all the uncertainties and possible residual light in the Galaxy are taken into account, and thus it most likely has the extragalactic origin (i.e., the COB). The derived COB brightness is (1.8 ± 0.9) × 10-9 and (1.2 ± 0.9) × 10-9 erg s-1 cm-2 sr-1 Å-1 at the blue and red bands, respectively, or 7.9 ± 4.0 and 7.7 ± 5.8 nW m-2 sr-1. From comparison with the integrated brightness of galaxies, we conclude that bulk of the COB is comprised of normal galaxies which have already been resolved in the current deepest observations. There seems to be little room for contributions of other populations including "first stars" at these wavelengths. On the other hand, the first component of the IPP residual light represents the diffuse Galactic light (DGL)—scattered starlight by the interstellar dust. We derive mean DGL-to-100 ?m brightness ratios of 2.1 × 10-3 and 4.6 × 10-3 at the two bands, which are roughly consistent with the previous observations toward the denser dust regions. Extended red emission in the diffuse interstellar medium is also confirmed.

Matsuoka, Y.; Ienaka, N.; Kawara, K.; Oyabu, S.

2011-08-01

115

10 CFR 431.12 - Definitions.  

Code of Federal Regulations, 2010 CFR

...Vocabulary Chapter 411: Rotating machines , sections 411-33-07...15) pertain to âcageâ; (iii) IEC Standard...and output series for rotating electrical machines...60034-12 (1980), Rotating electrical machines...single-speed three-phase cage induction motors...

2009-01-01

116

17,18-Dibromo-8-methyl-4,12-ditosyl-3,4,5,6,7,8,9,10,11,12,13,14-dodeca-hydro-2H-benzo[b][1,4,7,11,15]dioxatriaza-cyclo-hepta-decine  

PubMed Central

In the title compound, C31H39Br2N3O6S2, a 17-membered aza-macrocyclic ligand containing two ether O and three aza N atoms, the three pendant aromatic rings form an ‘E’ shape. The dihedral angles between the central benzene ring and the side ones are 17.8?(3) and 7.4?(3)°, and the dihedral angle between the tosyl rings is 10.6?(3)°. The methyl group is disordered over two orientations, with occupancies of 0.52?(15) and 0.48?(15).

Kelesoglu, Zeynep; Celenk Kaya, Elif; Kantekin, Halit; Buyukgungor, Orhan

2010-01-01

117

Summary of the Governor's Proposed 2010-11 Budget. Report 10-02  

ERIC Educational Resources Information Center

The proposed 2010-11 state budget closes an anticipated $20 billion funding gap as total State General Fund spending is expected to decline for the fourth consecutive year. The budget essentially maintains higher education and K-12 funding at 2009-10 levels, but proposes some policy changes to K-12 that will result in the loss of significant…

Woolfork, Kevin

2010-01-01

118

Study of the 11C(p,gamma) reaction via the indirect d(11C,12N)ntransfer reaction  

SciTech Connect

The {sup 11}C(p,{gamma}){sup 12}N reaction is expected to be an important branch point in supermassive low-metallicity stars because it could produce CNO seed nuclei before the traditional triple-alpha process turns on. In the present work, the d({sup 11}C, {sup 12}N)n transfer reaction was employed to evaluate this reaction using a radioactive ion beam of 150 MeV {sup 11}C with 6 x 10{sup 5} ions/s on target from the BEARS project at the 88-inch cyclotron at Lawrence Berkeley National Laboratory. Excellent agreement was obtained between the experimental cross sections ({theta}{sub c.m.} = 10.9{sup o} to 71.5{sup o}) and DWBA calculations. The asymptotic normalization coefficient was deduced to be (C{sub eff}{sup 12N}){sup 2} = (C{sub p1/2}{sup 12N}){sup 2} + (C{sub p3/2}{sup 12N}){sup 2} = 1.83 {+-} 0.27 fm{sup -1}.

Lee, Dongwon; Powell, James; Perajarvi, Kari; Guo, Fanqing; Moltz, Dennis; Cerny, Joseph

2008-01-07

119

12 CFR 1249.10 - Definitions.  

Code of Federal Regulations, 2013 CFR

...FEDERAL HOUSING FINANCE AGENCY ENTERPRISES BOOK-ENTRY PROCEDURES § 1249.10 Definitions... As used in this part, the term: Book-entry Enterprise Security means an Enterprise Security issued or maintained in the Book-entry System. Book-entry...

2013-01-01

120

11. Photographic copy of original asbuilt drawing, dated 10 July ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. Photographic copy of original as-built drawing, dated 10 July 1973 (original drawing in the possession of U.S. Army Corps of Engineers, Huntsville Division). Lower level plan - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Power Plant, In Limited Access Area, Southwest of PARB at end of Service Road B, Nekoma, Cavalier County, ND

121

Survey of the Pioneer 10 and 11 Jupiter mission  

NASA Technical Reports Server (NTRS)

After a description of the Pioneer 10 and 11 spacecraft, the following scientific experiments are discussed: Helium Vector Magnetometer, Fluxgate Magnetometer, Plasma Analyzer, Geiger Tube Telescope, Cosmic Ray Telescope, Trapped Radiation Detector, Ultraviolet Photometer, Imaging Photopolarimeter, Infrared Radiometer, Asteroid-Meteoroid Detector, and Meteoroid detector. Also reviewed are the mission profile and status.

Wolfe, J. H.

1976-01-01

122

Adipose Depletion and Apoptosis Induced by Trans10, Cis12 Conjugated Linoleic Acid in Mice  

Microsoft Academic Search

Objective: To compare the effectiveness of a conjugated linoleic acid (CLA) isomer mixture (mCLA) with each main isomer [trans-10,cis-12 CLA (CLA10,12) and cis-9,trans-11 CLA (CLA9,11)] in causing body lipid loss and adipose tissue apoptosis.Research Methods and Procedures: Mice selected over 16 generations for high (MH) or low (ML) energy expenditure and a control group (MC) were fed diets containing either

Kimberly M. Hargrave; ChangLong Li; Brett J. Meyer; Stephen D. Kachman; Diane L. Hartzell; Mary Anne Della-Fera; Jess L. Miner; Clifton A. Baile

2002-01-01

123

Pioneer 10 and 11 (Jupiter and Saturn) magnetic field experiments  

NASA Technical Reports Server (NTRS)

Magnet field data obtained by the vector helium magnetometer (VHM) during the encounters of Jupiter (Pioneer 10 and 11) and Saturn (Pioneer 11) was analyzed and interpreted. The puzzling characteristics of the Jovian and Saturnian magnetospheric magnetic fields were studied. An apparent substorm (including thinning of the dayside tail current sheet) was observed at Jupiter, as well as evidence suggesting that at the magnetopause the cusp is at an abnormally low latitude. The characteristics of Saturn's ring current as observed by Pioneer 11 were dramatically different from those suggested by the Voyager observations. Most importantly, very strong perturbations in the azimuthal ring current magnetic field suggest that the plane of the ring was not in the dipole equatorial plane, being tilted 5 to 10 deg. relative to the dipole and undergoing significant changes during the encounter. When these changing currents were corrected for, an improved planetary field determination was obtained. In addition, the ring and azimuthal currents at Saturn displayed significantly different time dependences.

Jones, D. E.

1986-01-01

124

Designing Products. Grades 11-12. Course #8166 (Semester). Technology Education Course Guide.  

ERIC Educational Resources Information Center

This document contains teachers' materials for a 10-module, 1-semester technology education course in product design offered in grades 11 and 12 in North Carolina. The document begins with a rationale for the development of the course; an explanation of the elements in an instructional system; a rationale for the course; a description of the…

North Carolina State Dept. of Public Instruction, Raleigh.

125

12 CFR 1270.10 - Joint and several liability.  

Code of Federal Regulations, 2012 CFR

12 Banks and Banking 9 2012-01-01 2012-01-01...several liability. 1270.10 Section 1270.10 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS LIABILITIES Consolidated Obligations §...

2012-01-01

126

12 CFR 1261.10 - Independent director conflict of interests.  

Code of Federal Regulations, 2012 CFR

12 Banks and Banking 9 2012-01-01 2012-01-01...of interests. 1261.10 Section 1261.10 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS FEDERAL HOME LOAN BANK DIRECTORS Federal...

2012-01-01

127

29 CFR 11.12 - Content and format of environmental documents.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 false Content and format of environmental documents. 11.12 Section 11...Labor DEPARTMENT OF LABOR NATIONAL ENVIRONMENTAL POLICY ACT (NEPA) COMPLIANCE PROCEDURES... § 11.12 Content and format of environmental documents. (a) An...

2013-07-01

128

Irradiation performance of HTGR fuel rods in HFIR experiments HRB-11 and -12  

SciTech Connect

Capsules HRB-11 and -12 were irradiated in support of development of weak-acid-resin-derived recycle fuel for the high-enriched uranium (HEU) fuel cycle for the HTGR. Fissil fuel particles with initial oxygen-to-metal ratios between 1.0 and 1.7 performed acceptably to full burnup for HEU fuel. Particles with ratios below 1.0 showed excessive chemical interaction between rare earth fission products and the SiC layer.

Homan, F.J.; Tiegs, T.N.; Kania, M.J.; Long, E.L. Jr.; Thoms, K.R.; Robbins, J.M.; Wagner, P.

1980-06-01

129

12 CFR 1249.11 - Maintenance of Enterprise Securities.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 false Maintenance of Enterprise Securities. 1249.11 Section 1249.11 Banks and...PROCEDURES § 1249.11 Maintenance of Enterprise Securities. An Enterprise Security may be maintained in the form of a...

2012-01-01

130

Interstitial deletion 11(p11.12p11.2) and analphoid marker formation results in inherited Potocki-Shaffer syndrome.  

PubMed

We report a family with inherited Potocki-Shaffer syndrome. The phenotypically normal mother has an interstitial deletion of 11(p11.12p11.2) with neocentric marker chromosome formation. The marker chromosome contains the deleted material on 11p11.2 and is likely a ring. The patient inherited a maternal deleted chromosome 11 but not the marker chromosome, thus resulting in an unbalanced karyotype along with the phenotype of Potocki-Shaffer syndrome. The deleted region in our case-11p11.12p11.2-is a newly reported site of constitutional neocentromere formation. This is also the first report describing deletion of 11p11.12-p11.2 and neocentromere formation resulting in inherited Potocki-Shaffer syndrome. PMID:15666301

Chuang, Louise; Wakui, Keiko; Sue, Whey-Chen; Su, Mei-Hsu; Shaffer, Lisa G; Kuo, Pao-Lin

2005-03-01

131

Ultrasmall Au10-12 (SG)10-12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy.  

PubMed

Radiosensitizers can increase local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, a new class of radiosensitizers is reported, which contain several gold (Au) atoms embedded inside a peptide shell (e.g., Au10-12 (SG)10-12 ) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement. PMID:24817169

Zhang, Xiao-Dong; Luo, Zhentao; Chen, Jie; Shen, Xiu; Song, Shasha; Sun, Yuanming; Fan, Saijun; Fan, Feiyue; Leong, David Tai; Xie, Jianping

2014-07-01

132

Trans-10, cis-12 Conjugated Linoleic Acid Decreases de novo Lipid Synthesis in Human Adipocytes  

PubMed Central

Conjugated linoleic acid (CLA) reduces adiposity in vivo. However, mechanisms mediating these changes are unclear. Therefore, we treated cultures of human adipocytes with trans-10, cis-12 (10,12) CLA, cis-9, trans-11 (9,11) CLA, or other trans fatty acids (FA) and measured indices of lipid metabolism. The lipid-lowering effects of 10,12 CLA were unique, as other trans FA did not reduce TG content to the same extent. Using low levels of [14C]-CLA isomers, it was shown that both isomers were readily incorporated into acylglycerols and phospholipids, albeit at lower levels than [14C]-oleic or [14C]-linoleic acids. When using [14C]-acetic acid and [14C]-pyruvic acid as substrates, 30 ?M 10,12 CLA, but not 9,11 CLA, decreased de novo synthesis of triglyceride (TG), free FA, diacylglycerol, cholesterol esters, cardiolipin, phospholipids, and ceramides within 3–24 h. Treatment with 30 ?M 10,12 CLA, but not 9,11 CLA, decreased total cellular lipids within 3 d and the ratio of monounsaturated FA (MUFA) to saturated FA, and increased C18:0 acyl-CoA levels within 24 h. Consistent with these data, stearoyl-CoA desaturase (SCD)-1 mRNA and protein levels were down-regulated by 10,12 CLA within 7–12 h, respectively. The mRNA levels of liver X receptor (LXR)? and sterol regulatory element binding protein (SREBP)-1c, transcription factors that regulate SCD-1, were decreased by 10,12 CLA within 5 h. These data suggest that the isomer-specific decrease in de novo lipid synthesis by 10,12 CLA is due, in part, to the rapid repression of lipogenic transcription factors that regulate MUFA synthesis, suggesting an anti-obesity mechanism unique to this trans FA.

Obsen, Thomas; Faergeman, Nils J.; Chung, Soonkyu; Martinez, Kristina; Gobern, Semone; Loreau, Olivier; Wabitsch, Martin; Mandrup, Susanne; McIntosh, Michael

2011-01-01

133

Resonance Ionization Spectroscopy of Stable Strontium Isotopes and Sr-90 via 5s(2)S-1(0) -> 5s5p P-1(1) -> 5s5d D-1(2) -> 5s11fF-1(3) -> Sr+  

SciTech Connect

Single-, double- and triple-resonance ionization in the 5s2 1S0? 5s5p 1P1 - 5s5d 1D2 - 5s11f 1F3 - Sr+ system of strontium was investigated to achieve an efficient and highly selective ionization scheme for ultra-trace detection of the radioisotope 90Sr. Isotope shifts and hyperfine structure for all stable isotopes of Sr were measured in all three resonant transitions. Good agreement with previous data was found in the 5s2 1S0 - 5s5p 1P1 transition and precision was improved by about one order of magnitude. Isotope shifts, including that for 90Sr, and hyperfine structure in the two- and three-photon transitions were measured for the first time. The double- and triple-resonance schemes were characterized with respect to their isotopic selectivity for detection of 90Sr. The double-resonance process offers an optical selectivity of 2-104, while unfavorable isotope shifts in the triple-resonance process limit it-s selectivity to {approx}100. Using double-resonance ionization combined with mass spectrometric detection, an overall detection efficiency of > 10-5, a selectivity > 1010, and a detection limit of 0.7 fg 90Sr in samples with a 1010 excess of stable Sr isotopes have been demonstrated.

Bushaw, Bruce A. (BATTELLE (PACIFIC NW LAB)); Nortershauser, Wilfred (AWU)

1999-11-01

134

10. Historic American Buildings Survey Alex Bush, Photographer, September 12, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. Historic American Buildings Survey Alex Bush, Photographer, September 12, 1935 OLD SLAVE HOUSE, SMOKE HOUSE IN REAR - Greenlawn, U.S. Highway 431 (Memorial Parkway), Huntsville, Madison County, AL

135

DAP10- and DAP12-associated receptors in innate immunity  

PubMed Central

Summary The DAP10 and DAP12 signaling subunits are highly conserved in evolution and associate with a large family of receptors in hematopoietic cells, including dendritic cells, plasmacytoid dendritic cells, neutrophils, basophils, eosinophils, mast cells, monocytes, macrophages, natural killer cells, and some B and T cells. Some receptors are able to associate with either DAP10 or DAP12, which contribute unique intracellular signaling functions. Studies of humans and mice deficient in these signaling subunits have provided surprising insights into the physiological functions of DAP10 and DAP12, demonstrating that they can either activate or inhibit immune responses. DAP10- and DAP12-associated receptors have been shown to recognize both host-encoded ligands and ligands encoded by microbial pathogens, indicating that they play an important role in innate immune responses.

Lanier, Lewis L.

2009-01-01

136

Longterm and seasonal variation in the isotopic composition of tropospheric CFC-12 and CFC-11  

NASA Astrophysics Data System (ADS)

Strong carbon isotope fractionation effects were recently discovered for the degradation of chlorofluorocarbons (CFC's) in landfills and for their photolytical destruction in the troposphere. Both results suggest an enrichment in 13C in the residual fraction of these compounds over time. Thus the isotopic composition of these CFC's may improve our understanding of their fate and reduce uncertainties in current source estimates. Here we report carbon isotope ratios for CFC-11 (CFCl3) and CFC-12 (CF2Cl2)) in background air. The samples were taken during five sampling campaigns between September 2010 and July 2012 with the sample locations spanning from 10°N to 60°N. For CFC-12 our data indicate a long term 13C enrichment of 0.5‰ per year corrobating very recent results from firn air measurements. The long term enrichment is superimposed by a seasonal cycle with an amplitude of 1.2‰ with the most enriched ?13C values occurring in June /July. We hypothesize the long term trend and the seasonal cycle to be driven by the stratosphere troposphere exchange (STE) of CFC-12. The mean ?13C for CFC-11 was -28.4 ± 0.6‰ (n =82) without any significant spatial or temporal variation. The kinetic isotope effect for the photolytic degradation of CFC-11 in the stratosphere is substantially smaller as compared to that for CFC-12 resulting in a minor imprint of the STE on the isotopic composition of tropospheric CFC-11. Furthermore, in contrast to CFC-12, degradation of CFC-11 has been reported from a variety of oxygen deficient marine settings. This may result in small scale variations in the ?13C of tropospheric CFC-11 superimposing any seasonal variability.

Bahlmann, Enno; Weinberg, Ingo; Eckhardt, Tim; Michaelis, Walter; Seifert, Richard

2013-04-01

137

19 CFR 11.12 - Labeling of wool products to indicate fiber content.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 false Labeling of wool products to indicate fiber content. 11.12 Section 11.12 Customs Duties ...Marking § 11.12 Labeling of wool products to indicate fiber content. (a) Wool products imported into the...

2013-04-01

138

Search for a Broad 9.11 MeV 2^+ in ^12C*  

NASA Astrophysics Data System (ADS)

Carbon is formed during stellar helium burning in the ``triple- alpha process''-- the ^8Be(,)^12C reaction that is mostly governed by the 0^+ state at 7.654 MeV. At high temperatures (T > 3 GK) higher lying states in ^12C may contribute. A broad (??= 560 keV, ??= 0.2 eV) 2^+ state at 9.11 MeV in ^12C was included in the NACRE compilation following theoretical prediction for the 2^+ member of the rotational band built on top of the 0^+ state at 7.654 MeV. It increases the production of carbon at temperatures in excess of 1 GK by up to a factor of 15. An Optical-Readout Time Projection Chamber (O-TPC) operating with CO2 gas that is being used at the High Intensity ?-ray Source (HI?S) at TUNL is ideally suited for a search of such a state via the identification of triple alpha events from the ^12C(,?) reaction. We have studied this reaction at E? = 9.55, 10.54, 10.84 and 11.14 MeV. Only 4 triple alpha events were observed during a 10 hour long measurement at 9.55 MeV which are consistent with the known broad 1^- state at 10.84 MeV in ^12C. Using the known cross section of the ^16O(,)^12C (= 4.2 ?b) we place the upper limit of ??(0^+g.s.->2^+) < 1.28 meV at E?= 9.55 MeV, hence B(E2: 2^+ ->0^+g.s.) < 4 x10-3 W.u.^*Work supported by the U.S. Department of Energy grant No. DE- FG02-94ER40870 and DE-FG02-97ER41033.

Zimmerman, W. R.; Seo, P.-N.; Gai, M.; Ahmed, M. W.; Henshaw, S. S.; Howell, C. R.; Stave, S. C.; Weller, H. R.; Martel, P. P.

2009-05-01

139

Cryptic insertion into 11q23 of MLLT10 not involved in t(1;15;11;10)(p36;q11;q23;q24) in infant acute biphenotypic leukemia.  

PubMed

The MLL gene, located on chromosomal band 11q23, is fused to a large number of different partner genes in hematological malignancies. This report describes a case of infant acute biphenotypic leukemia with t(1;15;11;10)(p36;q11;q23;q24). Panhandle polymerase chain reaction (PCR) using cDNA demonstrated the formation of an MLL-MLLT10 fusion transcript, although the 10p12 segment, at which the MLLT10 gene is located, was not involved in the breakpoint of the four-way translocation according to G-banding and spectral karyotyping analyses. Long-distance inverse PCR using genomic DNA revealed that intron 7 of MLL was fused with intron 8 of MLLT10, which was connected with a DNA segment of noncoding region on 15q. In fluorescence in situ hybridization analyses, the duplicated 3' part of MLLT10 was inserted into the component of chromosome 15 on der(11)(q23). In real-time quantitative PCR with primers that recognized the DNA sequence of the two sites of fusion point, the minimal residual disease (MRD) levels changed in parallel with other clinical markers. Furthermore, the level of MRD had already increased before hematologic relapse. The identification and characterization of MLL rearrangement at the genomic DNA level may be useful for MRD quantification. PMID:19380030

Matsuda, Kazuyuki; Tanaka, Miyuki; Araki, Sachiko; Yanagisawa, Ryu; Yamauchi, Kazuyoshi; Koike, Kenichi

2009-04-15

140

Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia.  

PubMed

Fluorescence in situ hybridization (FISH) analysis in a case of infant acute monocytic leukemia M5 revealed a complex rearrangement between chromosomes 10 and 11, leading to the disruption of the MLL gene. Using two painting probes for chromosomes 10 and 11 and a specific probe for the MLL gene localized on 11q23, we observed a paracentric inversion of the 11q13-q23 fragment translocated to 10p12. Molecular analysis showed that AF10 localized on 10p12 was the fusion partner gene of MLL in this rearrangement (10;11). This report underlined the usefulness of FISH and molecular techniques in identifying complex rearrangements. PMID:12127405

Roll, Patrice; Zattara-Cannoni, Hélène; Bustos-Bernard, Marie Christine; Curtillet, Catherine; Michel, Gérard; Vagner-Capodano, Anne-Marie

2002-06-01

141

Cyclodehydration reactions of methyl 9,10-; 10,12-; and 9,12-dioxostearates with 1,2-diaminoethane under ultrasonic irradiation  

Microsoft Academic Search

Reaction of methyl 9,10-dioxostearate (1) and 9,12-dioxostearate (2) with 1,2-diaminoethane under concomitant ultrasonic irradiation (10–15 min, 60°C) in water furnished the corresponding 2,3-dihydropyrazine\\u000a (4, 79%) and 1,2,3,4-tetrahydro-1,4-diazocine (5, 70%) derivatives, respectively. Reaction of methyl 10,12-dioxostearate (3) with 1,2-diaminoethane was successful only when glacial acetic acid was used instead of water under ultrasonic irradiation\\u000a (4×10 min, 70°C) to give a 2,3-dihydro-1H-1,4-diazepine

Marcel S. F. Lie Ken Jie; Maureen M. L. Lau; Prabhavathi Kalluri

2001-01-01

142

Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.  

PubMed

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry. PMID:18794857

Barton, Anne; Thomson, Wendy; Ke, Xiayi; Eyre, Steve; Hinks, Anne; Bowes, John; Plant, Darren; Gibbons, Laura J; Wilson, Anthony G; Bax, Deborah E; Morgan, Ann W; Emery, Paul; Steer, Sophia; Hocking, Lynne; Reid, David M; Wordsworth, Paul; Harrison, Pille; Worthington, Jane

2008-10-01

143

43 CFR 11.10 - Scope and applicability.  

Code of Federal Regulations, 2013 CFR

...Interior NATURAL RESOURCE DAMAGE ASSESSMENTS Introduction § 11...trustees may assess damages to natural resources...seek to recover those damages. This part supplements...pursuant to the NCP. The assessment procedures set...

2013-10-01

144

10 CFR 11.21 - Application of the criteria.  

Code of Federal Regulations, 2013 CFR

...CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL Criteria for Determining Eligibility for Access To, Or Control Over, Special Nuclear Material § 11.21...

2014-01-01

145

10 CFR 11.13 - Special requirements for transportation.  

Code of Federal Regulations, 2013 CFR

...FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...Requirements for Special Nuclear Material Access Authorization § 11.13 Special...NRC-U special nuclear material access authorization. Exceptions...

2014-01-01

146

Imidazoline ring cleavage in 1,3,6,10-tetraazatetracyclo-(7. 3. 1. 0/sup 2,7/. 0/sup 6,13/)trideca-4,11-dienes, leading to the formation of diquinoxalino(1,2-. cap alpha. :2',3'-d)pyrrole derivatives  

SciTech Connect

Dibenzo(d,k)-1,3,6,10-tetraazatetracyclo(7.3.1.0/sup 2,7/.0/sup 6,13/) trideca-4,11-dienes undergo addition reactions at the C/sub (2)/ carbon atom with alcohols and thiols, accompanied by cleavage of the C-N bond of the imidazoline ring, to generate diquinoxalino(1,2-..cap alpha..:2',3'-d)pyrrole derivatives. /sup 1/H NMR spectra were recorded on Perkin-Elmer R 12B (60 MHz) and Bruker WH-90 spectrometer for CDCl/sub 3/ solutions at 40/sup 0/C and with TMS as internal standard. /sup 13/C NMR spectra were obtained on a Bruker WH-90 (22.62 MHz) spectrometer. /sup 13/C chemical shifts were measured relative to solvent signals (deltaCDCl/sub 3/ 77.0 ppm). /sup 13/C NMR spectra of compounds IIa and g were taken using full spin-spin carbon-proton decoupling. In order to measure SSCC the spectrum was recorded both with proton coupling and also with selective decoupling of individual protons and their attached /sup 13/C carbon nuclei.

Charushin, V.N.; Petrova, G.M.; Aleksandrov, G.G.; Egorova, L.G.; Chernishev, A.I.; Sidorov, E.O.; Klyuev, N.A.; Chupakhin, O.N.

1987-10-01

147

Music, Grades 10-12. Secondary Schools Curriculum Guide.  

ERIC Educational Resources Information Center

Nine courses are included in this music guide for grades 10-12: Music Theory; Humanities: Renaissance, Baroque, and Classical; Humanities: Idealism vs. Realism; Humanities: 20th Century Man and His World; A Capella Choir; Chorale; Band; and Basic Keyboard Study. Major objectives, numbered objectives, and activities indicate level of learning,…

Cranston School Dept., RI.

148

Teachers Guide to Economic Concepts: Grade 10-12.  

ERIC Educational Resources Information Center

This grades 10-12 teachers guide is one of five resource guides developed to aid teachers in helping students in South Dakota to achieve a high degree of economic literacy. It is felt that schools must prepare students at all grade levels to develop an understanding of the economy in which they live. This guide was specifically prepared to assist…

McCabe, Milo F.

149

12. Photographic copy of original asbuilt drawing, dated 10 July ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Photographic copy of original as-built drawing, dated 10 July 1973 (original drawing in the possession of U.S. Army Corps of Engineers, Huntsville Division). Upper lower level plan - Stanley R. Mickelsen Safeguard Complex, Perimeter Acquisition Radar Power Plant, In Limited Access Area, Southwest of PARB at end of Service Road B, Nekoma, Cavalier County, ND

150

45 CFR 12a.10 - Action on approved applications.  

Code of Federal Regulations, 2013 CFR

...OF FEDERAL REAL PROPERTY TO ASSIST THE HOMELESS § 12a.10 Action on approved applications...of consideration to uses to assist the homeless. GSA may consider any competing request...compelling that it outweighs the needs of the homeless, and HHS may likewise consider any...

2013-10-01

151

Social Studies, Grades 10-12. Secondary Schools Curriculum Guide.  

ERIC Educational Resources Information Center

This curriculum guide provides a one-year course in social studies for grades 10-12. The guide is intended to serve as a resource to teachers, students, department chairmen, guidance personnel, curriculum planners, and anyone else involved in present or future curriculum planning. The course is divided into 22 section areas covering the topics of…

Cranston School Dept., RI.

152

Newspapers and Law-Related Education. Grades 10-12.  

ERIC Educational Resources Information Center

Designed to assist teachers of students in grades 10-12 who wish to use the newspaper as a supplemental tool in law-related education, this guide provides model lessons demonstrating ways in which the daily newspaper can enhance textbook material. Although the guide is based on ongoing law-related education programs in St. Louis Public Schools, it…

Diamond, Sandra; Riekes, Linda

153

Secondary Schools Curriculum Guide, Science, Grades 10-12. Revised.  

ERIC Educational Resources Information Center

This curriculum guide offers instructional objectives and activities for teaching science in grades 10-12. The objectives are stated in behavioral or performance terms and have been arranged in increasing levels of complexity according to Bloom's Taxonomy. The behavioral objectives generally include: (1) the objective statement, specifying the…

Cranston School Dept., RI.

154

Determination of the astrophysical S factor for 11C(p,?)12N from the 12N?11C+p asymptotic normalization coefficient  

NASA Astrophysics Data System (ADS)

The evolution of very low-metallicity, massive stars depends critically on the amount of CNO nuclei that they produce. Alternative paths from the slow 3? process to produce CNO seed nuclei could change their fate. The 11C(p,?)12N reaction is an important branch point in one such alternative path. At energies appropriate to stellar evolution of very low-metallicity, massive stars, nonresonant capture dominates the reaction rate. We have determined the astrophysical S factor for the?11C(p,?)12N reaction using the asymptotic normalization coefficient for 12N?11C+p to fix the nonresonant capture rate. In our experiment, a 110 MeV 11C radioactive beam was used to study the14N(11C,12N)13C peripheral transfer reaction and the asymptotic normalization coefficient, (C12Npeff)2=(C12Np1/2)2+(C12Np3/2)2=1.73±0.25 fm-1, was extracted from the measured cross section. The contributions from the second resonance and interference effects were estimated using an R-matrix approach with the measured asymptotic normalization coefficient and the latest value for ??. We find the S factor for 11C(p,?)12N is significantly larger than previous estimates. As a result, the required density for it to contribute is reduced, and more CNO material may be produced.

Tang, Xiaodong; Azhari, A.; Gagliardi, C. A.; Mukhamedzhanov, A. M.; Pirlepesov, F.; Trache, L.; Tribble, R. E.; Burjan, V.; Kroha, V.; Carstoiu, F.

2003-01-01

155

Expression, purification and osteogenic bioactivity of recombinant human BMP-4, -9, -10, -11 and -14.  

PubMed

Bone morphogenetic proteins (BMPs) are cytokines from the TGF-beta superfamily, with important roles during embryonic development and in the induction of bone and cartilage tissue differentiation in the adult body. In this contribution, we report the expression of recombinant human BMP-4, BMP-9, BMP-10, BMP-11 (or growth differentiation factor-11, GDF-11) and BMP-14 (GDF-5), using Escherichia coli pET-25b vector. BMPs were overexpressed, purified by affinity his-tag chromatography and shown to induce the expression of early markers of bone differentiation (e.g. smad-1, smad-5, runx2/cbfa1, dlx5, osterix, osteopontin, bone sialoprotein and alkaline phosphatase) in C2C12 cells and in human adipose stem cells. The described approach is a promising method for producing large amounts of different recombinant BMPs that show potential for novel biomedical applications. PMID:18950713

Bessa, P C; Cerqueira, M T; Rada, T; Gomes, M E; Neves, N M; Nobre, A; Reis, R L; Casal, M

2009-02-01

156

Theoretical prediction of three-body cluster resonances in 11Li and 10He  

NASA Astrophysics Data System (ADS)

With the core+n+n three-body cluster model, we investigated 11Li and 10He. By using a 9Li-n interaction which reproduce the degeneracy of single particle s1/2- and p1/2-orbital states above the 9Li+n threshold, a low-lying excited resonance is predicted in 11Li together with the ground state, and they are found to be partners in mixed configurations of (0p1/2)2 and (1s1/2)2. The observed three-body resonance in 10He is considered to be the two valence neutrons mainly in the p-orbit, (0p1/2)2. In addition to a solution of the two valence neutrons in the p-orbit, we obtained a solution of the two valence neutrons mainly in the s-orbit, (1s1/2)2, as the ground state. Experimentally, such a state has not yet been observed. This newly predicted state of 10He with the main component of (1s1/2)2 would corresponds to the ground state of 11Li with a halo structure.

Aoyama, S.; Myo, T.; Kato, K.; Ikeda, K.

2002-11-01

157

A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20  

PubMed Central

Spinocerebellar ataxia type 20 (SCA20) has been linked to chromosome 11q12, but the underlying genetic defect has yet to be identified. We applied single-nucleotide polymorphism genotyping to detect structural alterations in the genomic DNA of patients with SCA20. We found a 260 kb duplication within the previously linked SCA20 region, which was confirmed by quantitative polymerase chain reaction and fiber fluorescence in situ hybridization, the latter also showing its direct orientation. The duplication spans 10 known and 2 unknown genes, and is present in all affected individuals in the single reported SCA20 pedigree. While the mechanism whereby this duplication may be pathogenic remains to be established, we speculate that the critical gene within the duplicated segment may be DAGLA, the product of which is normally present at the base of Purkinje cell dendritic spines and contributes to the modulation of parallel fiber-Purkinje cell synapses.

Knight, Melanie A.; Hernandez, Dena; Diede, Scott J.; Dauwerse, Hans G.; Rafferty, Ian; van de Leemput, Joyce; Forrest, Susan M.; Gardner, R.J.McKinlay; Storey, Elsdon; van Ommen, Gert-Jan B.; Tapscott, Stephen J.; Fischbeck, Kenneth H.; Singleton, Andrew B.

2008-01-01

158

43 CFR 10.11 - Disposition of culturally unidentifiable human remains.  

Code of Federal Regulations, 2010 CFR

...Disposition of culturally unidentifiable human remains. 10.11 Section 10.11...PROTECTION AND REPATRIATION REGULATIONS Human Remains, Funerary Objects, Sacred Objects...Disposition of culturally unidentifiable human remains. (a) General. This...

2012-10-01

159

43 CFR 10.11 - Disposition of culturally unidentifiable human remains.  

Code of Federal Regulations, 2010 CFR

...Disposition of culturally unidentifiable human remains. 10.11 Section 10.11...PROTECTION AND REPATRIATION REGULATIONS Human Remains, Funerary Objects, Sacred Objects...Disposition of culturally unidentifiable human remains. (a) General. This...

2010-10-01

160

Paroxysmal Kinesigenic Choreoathetosis Locus Maps to Chromosome 16p11.2-q12.1  

PubMed Central

Summary Paroxysmal kinesigenic choreoathetosis (PKC), the most frequently described type of paroxysmal dyskinesia, is characterized by recurrent, brief attacks of involuntary movements induced by sudden voluntary movements. Some patients with PKC have a history of infantile afebrile convulsions with a favorable outcome. To localize the PKC locus, we performed genomewide linkage analysis on eight Japanese families with autosomal dominant PKC. Two-point linkage analysis provided a maximum LOD score of 10.27 (recombination fraction [?] = .00; penetrance [p] = .7) at marker D16S3081, and a maximum multipoint LOD score for a subset of markers was calculated to be 11.51 (p = 0.8) at D16S3080. Haplotype analysis defined the disease locus within a region of ?12.4 cM between D16S3093 and D16S416. P1-derived artificial chromosome clones containing loci D16S3093 and D16S416 were mapped, by use of FISH, to 16p11.2 and 16q12.1, respectively. Thus, in the eight families studied, the chromosomal localization of the PKC critical region (PKCR) is 16p11.2-q12.1. The PKCR overlaps with a region responsible for “infantile convulsions and paroxysmal choreoathetosis” (MIM 602066), a recently recognized clinical entity with benign infantile convulsions and nonkinesigenic paroxysmal dyskinesias.

Tomita, Hiro-aki; Nagamitsu, Shinichiro; Wakui, Keiko; Fukushima, Yoshimitsu; Yamada, Koki; Sadamatsu, Miyuki; Masui, Akira; Konishi, Tohru; Matsuishi, Toyojiro; Aihara, Masao; Shimizu, Katsunori; Hashimoto, Kiyoshi; Mineta, Mari; Matsushima, Michihito; Tsujita, Takahiro; Saito, Masaaki; Tanaka, Hajime; Tsuji, Shoji; Takagi, Toshihisa; Nakamura, Yusuke; Nanko, Shinichiro; Kato, Nobumasa; Nakane, Yoshibumi; Niikawa, Norio

1999-01-01

161

Common variation at 10p12.31 near MLLT10 influences meningioma risk.  

PubMed

To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development. PMID:21804547

Dobbins, Sara E; Broderick, Peter; Melin, Beatrice; Feychting, Maria; Johansen, Christoffer; Andersson, Ulrika; Brännström, Thomas; Schramm, Johannes; Olver, Bianca; Lloyd, Amy; Ma, Yussanne P; Hosking, Fay J; Lönn, Stefan; Ahlbom, Anders; Henriksson, Roger; Schoemaker, Minouk J; Hepworth, Sarah J; Hoffmann, Per; Mühleisen, Thomas W; Nöthen, Markus M; Moebus, Susanne; Eisele, Lewin; Kosteljanetz, Michael; Muir, Kenneth; Swerdlow, Anthony; Simon, Matthias; Houlston, Richard S

2011-09-01

162

12 CFR 1310.11 - Considerations in making proposed and final determinations.  

Code of Federal Regulations, 2013 CFR

12 Banks and Banking 9 2013-01-01 2013-01-01...11 Section 1310.11 Banks and Banking FINANCIAL STABILITY OVERSIGHT COUNCIL AUTHORITY...SUPERVISION AND REGULATION OF CERTAIN NONBANK FINANCIAL COMPANIES Determinations §...

2013-01-01

163

MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity  

Microsoft Academic Search

Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French–American–British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant

Cristina Morerio; Annamaria Rapella; Cristina Rosanda; Edoardo Lanino; Luca Lo Nigro; Andrea Di Cataldo; Emanuela Maserati; Francesco Pasquali; Claudio Panarello

2004-01-01

164

Observation of ?-delayed 3 ? breakup of the 15.11 and 12.71 MeV states in 12C  

NASA Astrophysics Data System (ADS)

The reactions B10(He3,p???) at 4.9 MeV and B11(He3,d???) at 8.5 MeV have been used to investigate the ? decay of states in 12C. By measuring the four-body final state in complete kinematics we are able to detect ? transitions indirectly. We find ? transitions from the 15.11 MeV state in 12C to the 12.71, 11.83, 10.3 and 7.65 MeV states followed by their breakup into three ? particles. The relative ?-ray branching ratios obtained are (1.2±0.3), (0.32±0.12), (1.4±0.2) and (4.4±0.8)%, respectively, with the remaining (92.7±1.0)% of the ? decays going to the bound states. We obtain ?/?=(2.8±1.2)% for the isospin-forbidden ? decay of the 15.11 MeV state. From the 12.71 MeV state we find ? transitions to the 10.3 and 7.65 MeV states. The relative ?-ray branching ratios are (0.9-0.5+0.6) and (2.6-1.2+1.6)%, respectively, with the remaining (96.6-1.3+1.7)% of the ? decays going to the bound states. Finally, we discuss the relation between the ? decay of 12N and 12B to states in 12C and the ? decay of the 15.11 MeV analog in 12C to the same states.

Kirsebom, O. S.; Alcorta, M.; Borge, M. J. G.; Cubero, M.; Diget, C. A.; Dominguez-Reyes, R.; Fraile, L.; Fulton, B. R.; Fynbo, H. O. U.; Galaviz, D.; Garcia, G.; Hyldegaard, S.; Jeppesen, H. B.; Jonson, B.; Joshi, P.; Madurga, M.; Maira, A.; Muñoz, A.; Nilsson, T.; Nyman, G.; Obradors, D.; Perea, A.; Riisager, K.; Tengblad, O.; Turrion, M.

2009-09-01

165

Evidence that the trans -10, cis -12 isomer of conjugated linoleic acid induces body composition changes in mice  

Microsoft Academic Search

We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body\\u000a protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced

Jayne M. Storkson; Karen J. Albright; Wei Liu; Michael W. Pariza

1999-01-01

166

Interplanetary shock event of November 11/12 1978, a comprehensive test of acceleration theory  

SciTech Connect

A comprehensive study of the November 11/12, 1978 shock event based on energetic particle, solar wind, magnetic field and wave data from the ISEE-3, -1 and -2 spacecraft has been undertaken both from the energetic and the collisionless shock point of view. The energy density of 10-50 keV protons accelerated by the shock is found to be equivalent to the upstream magnetic field energy density. The observations are in quantitative agreement with Lee's (1983) self consistent theory for the excitation of hydromagnetic waves and the acceleration of ions upstream of interplanetary shocks.

Wenzel, K.P.; Sanderson, T.R.; Vannes, P.; Kennel, C.F.; Scarf, F.L.; Coroniti, F.V.; Russell, C.T.; Parks, G.K.; Smith, E.J.

1983-04-01

167

Crystal Structure of 8?-Hydroxyeremophil-7(11)-ene-12,8?(4?,6?)-diolide  

NASA Astrophysics Data System (ADS)

8?-Hydroxyeremophil-7(11)-ene-12,8?(4?,6?)-diolide was isolated from the Ligularia intermedia and characterized by MS, multi NMR and X-ray single crystal diffraction. Its crystal structure was determined as in a orthorhombic type, with space group P212121 with a=6.8519(5), b=10.7191(8), c=18.5942(14) Å, V =1365.67(18) Å3, Z=4, and the calculated density is 1.354 mg/m3. F(000)=592, µ=0.101 mm-1.

Xue, Hui-qing; Xue, Hui-feng; Wu, Biao; Wang, Han-qing; Xin, Xue-lei; Wu, Shui-xian

2006-12-01

168

38 CFR 58.12 - VA Forms 10-10EZ and 10-10EZR-Application for Health Benefits and Renewal Form.  

Code of Federal Regulations, 2011 CFR

38 Ç Pensions, Bonuses, and Veterans' Relief Ç 2 Ç 2013-07-01 Ç 2013-07-01 Ç false Ç VA Forms 10-10EZ and 10-10EZR-Application for Health Benefits and Renewal Form. Ç 58.12 Ç Section 58.12 Ç Pensions, Bonuses, and Veterans' Relief Ç DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) Ç FORMS Ç Â§ 58.12 Ç...

2013-07-01

169

MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity.  

PubMed

Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity. PMID:15262427

Morerio, Cristina; Rapella, Annamaria; Rosanda, Cristina; Lanino, Edoardo; Lo Nigro, Luca; Di Cataldo, Andrea; Maserati, Emanuela; Pasquali, Francesco; Panarello, Claudio

2004-07-15

170

Chromosomal-array analysis reveals partial 11q duplication and partial 12p deletion in a mildly affected case.  

PubMed

Partial trisomy 11q is a rare syndrome and may be observed due to an intra-chromosomal duplication or an inter-chromosomal insertion. The deletions of the short arm of chromosome 12 are also uncommon structural aberrations. Only a small fraction of structural chromosome anomalies are related to the unbalanced progeny of balanced translocation carrier parents. We here report on a 10-month-old baby boy who shows a very mild phenotype related to unique chromosomal abnormality, partial trisomy of 11q, and partial monosomy of 12p, due to the maternal balanced reciprocal translocation (11;12). The proband showed a 49.64?Mb duplication of 11q14.1-q25 and 0.44?Mb deletion of 12p13.33 in chromosomal array analysis. Since it is known that the duplications may cause a milder phenotype than deletions. Dysmorphic facial features, minor cardiac anomalies, respiratory distress, central nervous system anomalies, and psychomotor delay observed in the patient was similar to the reported pure 11q duplication cases, while behavioral problems observed in pure monosomy 12p cases could not be evaluated due to the young age of the patient. Phenotype-genotype correlation will be discussed in view of all the reported pure partial 11q trisomies and pure partial 12p deletion cases. PMID:24677787

Tu?, Esra; Yirmibe? Karao?uz, Meral; Kayhan, Gülsüm; Ergün, Mehmet Ali; Perçin, Ferda E

2014-07-01

171

17 CFR 270.12d1-1 - Exemptions for investments in money market funds.  

Code of Federal Regulations, 2013 CFR

...false Exemptions for investments in money market funds. 270.12d1-1 Section 270...12d1-1 Exemptions for investments in money market funds. (a) Exemptions for acquisition of money market fund shares. If the conditions...

2013-04-01

172

16p11.2-p12.2 duplication syndrome; a genomic condition differentiated from euchromatic variation of 16p11.2  

PubMed Central

Chromosome 16 contains multiple copy number variations (CNVs) that predispose to genomic disorders. Here, we differentiate pathogenic duplications of 16p11.2–p12.2 from microscopically similar euchromatic variants of 16p11.2. Patient 1 was a girl of 18 with autism, moderate intellectual disability, behavioural difficulties, dysmorphic features and a 7.71-Mb (megabase pair) duplication (16:21?521?005–29?233?146). Patient 2 had a 7.81-Mb duplication (16:21?382?561–29?191?527), speech delay and obsessional behaviour as a boy and, as an adult, short stature, macrocephaly and mild dysmorphism. The duplications contain 65 coding genes of which Polo-like kinase 1 (PLK1) has the highest likelihood of being haploinsufficient and, by implication, a triplosensitive gene. An additional 1.11-Mb CNV of 10q11.21 in Patient 1 was a possible modifier containing the G-protein-regulated inducer of neurite growth 2 (GPRIN2) gene. In contrast, the euchromatic variants in Patients 3 and 4 were amplifications from a 945-kb region containing non-functional immunoglobulin heavy chain (IGHV), hect domain pseudogene (HERC2P4) and TP53-inducible target gene 3 (TP53TG3) loci in proximal 16p11.2 (16:31?953?353–32?898?635). Paralogous pyrosequencing gave a total copy number of 3–8 in controls and 8 to >10 in Patients 3 and 4. The 16p11.2–p12.2 duplication syndrome is a recurrent genomic disorder with a variable phenotype including developmental delay, dysmorphic features, mild to severe intellectual disability, autism, obsessive or stereotyped behaviour, short stature and anomalies of the hands and fingers. It is important to differentiate pathogenic 16p11.2–p12.2 duplications from harmless, microscopically similar euchromatic variants of proximal 16p11.2, especially at prenatal diagnosis.

Barber, John C K; Hall, Victoria; Maloney, Viv K; Huang, Shuwen; Roberts, Angharad M; Brady, Angela F; Foulds, Nicki; Bewes, Beverley; Volleth, Marianne; Liehr, Thomas; Mehnert, Karl; Bateman, Mark; White, Helen

2013-01-01

173

Neuroblastoma in a boy with MCA/MR syndrome, deletion 11q, and duplication 12q  

SciTech Connect

Deletion 11q23{r_arrow}qter and duplication 12q23{r_arrow}qter are described in a boy with neuroblastoma, multiple congenital anomalies, and mental retardation. The patient has clinical manifestations of 11q deletion and 12q duplication syndromes. The possible involvement of the segment 11q23{r_arrow}24 in the cause of the neuroblastoma is discussed. 18 refs., 2 figs., 1 tab.

Koiffmann, C.P.; Vianna-Morgante, A.M.; Wajntal, A. [Univ. of Sao Paulo (Brazil)] [and others

1995-07-31

174

t10,c12 conjugated linoleic acid induces compensatory growth after immune challenge  

Microsoft Academic Search

Previous work demonstrated that feeding commercial preparations of conjugated linoleic acid (CLA) [a 50:50 mixture of c9,t11 and t10,c12 CLA (cCLA)] partially overcame lipopolysaccharide (LPS)-induced growth depression. The objective of this study was to determine which CLA isomer was responsible for the reduction of LPS-induced growth depression. Dietary cCLA supplementation for 3 weeks protected mice from LPS-induced weight loss 24

Daniel E. Butz; Guangming Li; Mark E. Cook

2006-01-01

175

Factors affecting self-reported physical activity in children ages 10--12  

Microsoft Academic Search

This study examined the relationship between the current level of physical activity in older school-age children and their self-perception of what promotes and hinders their participation in physical activity. The study also addresses how well Pender's Health Promotion Model (HPM) predicted older school-age children's current level of physical activity.^ One hundred fifty one 10, 11, and 12 year old children

Shirley Sherrick-Escamilla

2007-01-01

176

GAD2 on Chromosome 10p12 Is a Candidate Gene for Human Obesity  

Microsoft Academic Search

The gene GAD2 encoding the glutamic acid decarboxylase enzyme (GAD65) is a positional candidate gene for obesity on Chromosome 10p11–12, a susceptibility locus for morbid obesity in four independent ethnic populations. GAD65 catalyzes the formation of ?-aminobutyric acid (GABA), which interacts with neuropeptide Y in the paraventricular nucleus to contribute to stimulate food intake. A case-control study (575 morbidly obese

Philippe Boutin; Christian Dina; Francis Vasseur; Séverine Dubois; Laetitia Corset; Karin Séron; Lynn Bekris; Janice Cabellon; Bernadette Neve; Valérie Vasseur-Delannoy; Mohamed Chikri; M. Aline Charles; Karine Clement; Ake Lernmark; Philippe Froguel

2003-01-01

177

Study of the unbound nucleus {sup 11}N by the {sup 12}C({sup 14}N,{sup 15}C){sup 11}N transfer reaction  

SciTech Connect

A spectroscopic study of the proton-rich, particle unstable nucleus {sup 11}N has been performed using the multi-nucleon transfer reaction {sup 12}C({sup 14}N,{sup 15}C){sup 11}N at 30 AMeV incident energy at GANIL. Levels of {sup 11}N are observed as well defined resonances in the spectrum of the {sup 15}C-ejectiles. They are localized at 2.18(5), 3.63(5), 4.39(5), 5.12(8) and 5.87(15) MeV above the {sup 10}C+p threshold. The comparison of the measured widths with R-matrix calculations allows the estimation of spins and parities for these resonances.

Lepine-Szily, A.; Lichtenthaler, R. [IFUSP-Universidade de Sao Paulo, C.P. 66318, 05389-970 Sao Paulo (Brazil); Oliveira, J. M. Jr [IFUSP-Universidade de Sao Paulo, C.P. 66318, 05389-970 Sao Paulo (Brazil); Departamento de Ciencias e Matematica da Universidade de Sorocaba, Sorocaba (Brazil); Ostrowski, A. N. [Department of Physics and Astronomy, University of Edinburgh, Edinburgh, EH9 3JZ United Kingdom (United Kingdom); Bohlen, H. G.; Blazevic, A.; Oertzen, W. von; Stolla, Th. [Hahn-Meitner Institut, Glienicker Strasse 100, D-14109 Berlin (Germany); Borcea, C. [Institute of Atomic Physics, Bucharest (Romania); Guimaraes, V. [UNIP-Objetivo, R. Dr. Bacelar 1212, 04026-002, Sao Paulo (Brazil); Kalpakchieva, R. [Flerov Laboratory of Nuclear Reactions, JINR, Dubna, 141980 Dubna (Russian Federation); Lapoux, V. [CEA/DSM/DAPNIA/SPhN, CEN Saclay, 91191 Gif-sur-Yvette (France); MacCormick, M.; Oliveira, F.; Roussel-Chomaz, P. [GANIL, Bld Henri Becquerel, BP 5027, 14021 Caen Cedex (France); Orr, N. A.; Winfield, J. S. [LPC-ISMRa, Bld du Marechal Juin, 14050 Caen Cedex (France)

1998-12-21

178

Determination of astrophysical 11C(p, ?)12N reaction rate from the asymptotic normalization coefficients of 12B ?11B + n  

NASA Astrophysics Data System (ADS)

The squares of the neutron asymptotic normalization coefficient (ANC) for the virtual decay 12B ?11B + n are extracted to be 1.20 ± 0.26, 0.354 ± 0.107 and 1.98 ± 0.35 fm-1 from the angular distributions of the 11B(d, p)12B reaction leading to the ground, first and second excited states of 12B respectively, using the Johnson Soper approach. According to charge symmetry of strong interaction, the square of proton ANC of virtual decay 12N ?11C + p is determined to be 1.63 ± 0.35 fm-1 and then utilized to calculate the astrophysical S-factor and the rate of the direct capture contribution in the 11C(p, ?)12N reaction. The astrophysical S-factor at zero energy for the direct capture, S(0), is derived to be 0.088 ± 0.019 keV b. An evaluated S(0) of 0.092 ± 0.009 keV b is then given by using the present and pre-existing experimental results. In addition, the proton widths of the first and second excited states of 12N are derived to be 0.91 ± 0.29 and 99 ± 20 keV from the neutron ANCs of 12B and used to compute the contribution from the first two resonances of 12N, respectively. We have also calculated the contribution from the interference effect between the direct capture and the second resonance.

Guo, B.; Li, Z. H.; Liu, W. P.; Bai, X. X.

2007-01-01

179

High Potassium Intake Enhances the Inhibitory Effect of 11,12-EET on ENaC  

PubMed Central

High dietary potassium stimulates the renal expression of cytochrome P450 (CYP) epoxygenase 2C23, which metabolizes arachidonic acid (AA). Because the AA metabolite 11,12-epoxyeicosatrienoic acid (11,12-EET) can inhibit the epithelial sodium channel (ENaC) in the cortical collecting duct, we tested whether dietary potassium modulates ENaC function. High dietary potassium increased 11,12-EET in the isolated cortical collecting duct, an effect mimicked by inhibiting the angiotensin II type I receptor with valsartan. In patch-clamp experiments, a high potassium intake or treatment with valsartan enhanced AA-induced inhibition of ENaC, an effect mediated by a CYP-epoxygenase–dependent pathway. Moreover, high dietary potassium and valsartan each augmented the inhibitory effect of 11,12-EET on ENaC. Liquid chromatography/mass spectrometry showed that the rate of EET conversion to dihydroxyeicosatrienoic acids (DHET) was lower in renal tissue obtained from rats on a high-potassium diet than from those on a control diet, but this was not a result of altered expression of soluble epoxide hydrolase (sEH). Instead, suppression of sEH activity seemed to be responsible for the 11,12-EET–mediated enhanced inhibition of ENaC in animals on a high-potassium diet. Patch-clamp experiments demonstrated that 11,12-DHET was a weak inhibitor of ENaC compared with 11,12-EET, whereas 8,9- and 14,15-DHET were not. Furthermore, inhibition of sEH enhanced the 11,12-EET–induced inhibition of ENaC similar to high dietary potassium. In conclusion, high dietary potassium enhances the inhibitory effect of AA and 11,12-EET on ENaC by increasing CYP epoxygenase activity and decreasing sEH activity, respectively.

Sun, Peng; Lin, Dao-Hong; Yue, Peng; Jiang, Houli; Gotlinger, Katherine H.; Schwartzman, Michal L.; Falck, John R.; Goli, Mohan

2010-01-01

180

States in 12B from measurement and R-matrix analysis of sigma(theta) for 11B(n, n)11B  

Microsoft Academic Search

Differential cross sections for neutrons elastically scattered from 11B have been measured for 85 incident neutron energies for 2.6 <= En <= 8.0 MeV corresponding to excitation energies in 12B of 5.7 to 10.7 MeV. The cross sections were measured at nine laboratory angles per energy from 20° to 160° and show considerable resonance structure. These data, along with previously

R. M. White; H. D. Knox; J. M. Cox

1980-01-01

181

Oleic Acid Attenuates trans-10, cis-12 Conjugated Linoleic Acid-Mediated Inflammatory Gene Expression in Human Adipocytes  

PubMed Central

The weight loss supplement conjugated linoleic acid (CLA) consists of an equal mixture of trans-10, cis-12 (10,12) and cis-9, trans-11 (9,11) isomers. However, high levels of mixed CLA isomers, or the 10,12 isomer, causes chronic inflammation, lipodystrophy, or insulin resistance. We previously demonstrated that 10,12 CLA decreases de novo lipid synthesis along with the abundance and activity of stearoyl-CoA desaturase (SCD)-1, a delta-9 desaturase essential for the synthesis of monounsaturated fatty acids (MUFA). Thus, we hypothesized that the 10,12 CLA-mediated decrease in SCD-1, with the subsequent decrease in MUFA, was responsible for the observed effects. To test this hypothesis, 10,12 CLA-treated human adipocytes were supplemented with oleic acid for 12 h to 7 d, and inflammatory gene expression, insulin-stimulated glucose uptake, and lipid content were measured. Oleic acid reduced inflammatory gene expression in a dose-dependent manner, and restored the lipid content of 10,12 CLA-treated adipocytes without improving insulin-stimulated glucose uptake. In contrast, supplementation with stearic acid, a substrate for SCD-1, or 9,11 CLA did not prevent inflammatory gene expression by 10,12 CLA. Notably, 10,12 CLA impacted the expression of several G-protein coupled receptors that was attenuated by oleic acid. Collectively, these data show that oleic acid attenuates 10,12 CLA-induced inflammatory gene expression and lipid content, possibly by alleviating cell stress caused by the inhibition of MUFA needed for phospholipid and neutral lipid synthesis.

Reardon, Meaghan; Gobern, Semone; Martinez, Kristina; Shen, Wan; Reid, Tanya; McIntosh, Michael

2012-01-01

182

Oleic acid attenuates trans-10,cis-12 conjugated linoleic acid-mediated inflammatory gene expression in human adipocytes.  

PubMed

The weight loss supplement conjugated linoleic acid (CLA) consists of an equal mixture of trans-10,cis-12 (10,12) and cis-9,trans-11 (9,11) isomers. However, high levels of mixed CLA isomers, or the 10,12 isomer, causes chronic inflammation, lipodystrophy, or insulin resistance. We previously demonstrated that 10,12 CLA decreases de novo lipid synthesis along with the abundance and activity of stearoyl-CoA desaturase (SCD)-1, a ?-9 desaturase essential for the synthesis of monounsaturated fatty acids (MUFA). Thus, we hypothesized that the 10,12 CLA-mediated decrease in SCD-1, with the subsequent decrease in MUFA, was responsible for the observed effects. To test this hypothesis, 10,12 CLA-treated human adipocytes were supplemented with oleic acid for 12 h to 7 days, and inflammatory gene expression, insulin-stimulated glucose uptake, and lipid content were measured. Oleic acid reduced inflammatory gene expression in a dose-dependent manner, and restored the lipid content of 10,12 CLA-treated adipocytes without improving insulin-stimulated glucose uptake. In contrast, supplementation with stearic acid, a substrate for SCD-1, or 9,11 CLA did not prevent inflammatory gene expression by 10,12 CLA. Notably, 10,12 CLA impacted the expression of several G-protein coupled receptors that was attenuated by oleic acid. Collectively, these data show that oleic acid attenuates 10,12 CLA-induced inflammatory gene expression and lipid content, possibly by alleviating cell stress caused by the inhibition of MUFA needed for phospholipid and neutral lipid synthesis. PMID:22941440

Reardon, Meaghan; Gobern, Semone; Martinez, Kristina; Shen, Wan; Reid, Tanya; McIntosh, Michael

2012-11-01

183

46 CFR 195.11-10 - Design and construction of portable vans.  

Code of Federal Regulations, 2013 CFR

...2013-10-01 false Design and construction of portable...Tanks § 195.11-10 Design and construction of portable vans. (a) The design and material selection...of escape, arrangement, interior construction, and...

2013-10-01

184

The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene.  

PubMed

The gene on chromosome 10 at band p12 (AF10), involved in the t(10;11) translocation in acute myeloid leukemia, has been identified and shown to contain conserved zinc finger and leucine zipper domains. These regions are highly homologous to the equivalent regions on AF17, the gene involved in the t(11;17) translocations. A series of adult, childhood, and infant leukemias with either simple or complex versions of the t(10;11) has been examined by Southern analysis and shown to involve rearrangement to the HRX locus. Reverse transcriptase-polymerase chain reaction from either bone marrow or peripheral blood cells showed that HRX sequence was fused to AF10 sequence in all 8 cases and subsequent sequence analysis showed an in-frame fusion between the HRX and AF10 sequence. A consistent feature of these fusions was the juxtaposition of the leucine dimerization motif of AF10 onto the NH2-terminal region of HRX. The published data suggest that a similar conclusion can be drawn about the t(11;17) translocation, implying a critical role for this motif in the chimaeric HRX protein. PMID:7662954

Chaplin, T; Bernard, O; Beverloo, H B; Saha, V; Hagemeijer, A; Berger, R; Young, B D

1995-09-15

185

Li-6/Li-7, B-10/B-11, and Li-7/B-11/Si-28 individual IDPs  

NASA Technical Reports Server (NTRS)

At the initial stage of the development of our solar system, the solar nebula is presumably composed of H-1, H-2, He-3, He-4, and Li-7, which were made during the Big Band, and C, N, O, . . ., which are products of nearby supernova explosions. Li-6 nuclei (together with about equal amounts of Li-7), Be-9, B-10, and B-11 were produced later by cosmic ray particles bombarding the local interstellar C, N, O, . . . nuclei before the nebula condensed to become the Sun and the planets. Thus, the ratio Li-6/Li-7 is a measure of the length of the early epoch of the solar system. In this paper we shall report the measurement of Li-7/Li-6, B-11/B-10, and Li-7/B-11/Si-28 of four IDP's obtained from Johnson Space Center and discuss the findings.

Xu, Y.-L.; Song, L.-G.; Zhang, Y.-X.; Fan, C.-Y.

1994-01-01

186

The tyrosinase-positive oculocutaneous albinism locus maps to chromosome 15q11. 2-q12  

SciTech Connect

Tyrosinase-positive oculocutaneous albinism (ty-pos OCA), an autosomal recessive disorder of the melanin biosynthetic pathway, is the most common type of albinism occurring worldwide. In southern African Bantu-speaking negroids it has an overall prevalence of about 1/3,900. Since the basic biochemical defect is unknown, a linkage study with candidate loci, candidate chromosomal regions, and random loci was undertaken. The ty-pos OCA locus was found to be linked to two arbitrary loci, D15S10 and D15S13, in the Prader-Willi/Angelman chromosomal region on chromosome 15q11.2-q12. The pink-eyed dilute locus, p, on mouse chromosome 7, maps close to a region of homology on human chromosome 15q, and we postulate that the ty-pos OCA and p loci are homologous. 43 refs., 2 figs., 1 tab.

Ramsay, M.; Colman, M.A.; Stevens, G.; Zwane, E.; Kromberg, J.; Jenkins, T. (South African Institute for Medical Research, Johannesburg (South Africa)); Garral, M.

1992-10-01

187

Murine Monoclonal Anti-Idiotype Antibody 11D10 and Methods of Use Thereof.  

National Technical Information Service (NTIS)

The present invention provides a monoclonal anti-Idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that p...

K. A. Foon M. Chatterjee S. K. Chatterjee

2005-01-01

188

47 CFR 11.12 - Two-tone Attention Signal encoder and decoder.  

Code of Federal Regulations, 2010 CFR

...Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL EMERGENCY ALERT SYSTEM (EAS) General § 11.12 Two-tone Attention...two-tone Attention Signal will be used to provide an audio alert. [60 FR 55999, Nov. 6,...

2010-10-01

189

47 CFR 11.12 - Two-tone Attention Signal encoder and decoder.  

Code of Federal Regulations, 2011 CFR

...Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL EMERGENCY ALERT SYSTEM (EAS) General § 11.12 Two-tone Attention...two-tone Attention Signal will be used to provide an audio alert. [60 FR 55999, Nov. 6,...

2011-10-01

190

Understanding average speed: a study on students aged 11 to 12 years  

NASA Astrophysics Data System (ADS)

This article presents research aimed at designing a strategy to help students aged 11 to 12 years understand the concept of speed. In our approach the work of students is based on experimental activities integrated with Logo programming.

Borghi, L.; DeAmbrosis, A.; Massara, C. I.

1993-01-01

191

10 CFR 1046.12 - Physical fitness training program.  

...2014-01-01 2014-01-01 false Physical fitness training program. 1046.12...DEPARTMENT OF ENERGY (GENERAL PROVISIONS) PHYSICAL PROTECTION OF SECURITY INTERESTS (Eff...Protective Force Personnel § 1046.12 Physical fitness training program....

2014-01-01

192

Focusing of alkaline proteases (subtilisins) in pH 10-12 immobilized gradients.  

PubMed

Isoelectric focusing in very alkaline immobilized pH gradients (IPG) was adopted for checking the purity and assessing the pI value of two strongly alkaline proteases: Savinase and Durazym. The first enzyme (known to be the most alkaline) contains 5 Asp, 5 Glu, 7 His, 7 Tyr, 5 Lys, no Cys and 8 Arg residues and should have a theoretical pI of 9.7. Yet, when focused in a pH 9-11 IPG interval, it was lost in the cathodic compartment. After repeated attempts at creating even more alkaline pH intervals, a pH 10-12 IPG range was finally optimized and proved successful in focusing both enzymes midway between the two electrodic compartments. The pI of Savinase was measured as 11.15 +/- 0.15; that of Durazym as 10.95 +/- 0.20 and that of the pI marker cytochrome c as 10.6 +/- 0.17. Both enzymes (and a number of minor components in each preparation) were proven to be active by an in situ zymogram consisting of a casein/agar overlay. The discrepancy between theoretical and experimental pI values could not be fully reconciled: when correcting for pK values of amino acids in proteins at 10 degrees C, instead of the tabulated values at 25 degrees C, the pI should increase to a value of 10. Differential UV spectra showed that ca. 1/2 Tyr are buried in the protein interior and are thus unable to contribute to surface charge. This further increases the pI value by 0.3 pH units to a value of 10.3, still quite removed from the experimentally assessed pI value (in the gel, at 10 degrees C) of 11.15. PMID:7720691

Bossi, A; Righetti, P G; Vecchio, G; Severinsen, S

1994-12-01

193

Comets C/2003 X5-X11 and Y2-Y10 (SOHO)  

NASA Astrophysics Data System (ADS)

Further to IAUC 8356, K. Battams reports measurements for additional Kreutz sungrazing comets found on SOHO website C2 images by M. Boschat (C/2003 X5, X7, Y5, Y8), X.-m. Zhou (C/2003 X6, X9, X11), T. Hoffman (C/2003 X8), X. Leprette (C/2003 X10, Y2), R. Matson (2003 Y3, Y9, Y10), R. Kracht (C/2003 Y4, Y7), and J. Sachs (C/2003 Y6). C/2003 Y6 and Y7 were also visible on C3 images. The reductions by B. G. Marsden (and by R. Kisala for C/2003 Y8, Y9, Y10) and orbital elements by Marsden appear on the MPECs cited below. Comet 2003 UT R.A. (2000) Decl. MPEC C/2003 X5 Dec. 4.896 16 46.9 -24 12 2004-L24 C/2003 X6 6.396 16 52.2 -24 20 2004-L24 C/2003 X7 7.829 16 58.6 -24 27 2004-L24 C/2003 X8 8.246 17 00.9 -24 31 2004-L24 C/2003 X9 8.621 17 02.2 -24 34 2004-L24 C/2003 X10 11.188 17 14.5 -24 41 2004-L25 C/2003 X11 13.588 17 25.7 -24 57 2004-L25 C/2003 Y2 19.621 17 53.6 -25 08 2004-L25 C/2003 Y3 19.979 17 55.0 -25 02 2004-L25 C/2003 Y4 20.729 17 58.8 -25 14 2004-L25 C/2003 Y5 22.771 18 08.5 -25 08 2004-L25 C/2003 Y6 23.571 18 14.3 -27 22 2004-L26 C/2003 Y7 24.638 18 20.0 -27 44 2004-L26 C/2003 Y8 25.288 18 19.6 -25 00 2004-L67 C/2003 Y9 25.479 18 20.7 -24 46 2004-L67 C/2003 Y10 26.064 18 23.5 -24 50 2004-L67

Battams, K.; Boschat, M.; Zhou, X.-M.; Hoffman, T.; Leprette, X.; Matson, R.; Kracht, R.; Sachs, J.; Marsden, B. G.; Kisala, R.

2004-06-01

194

34. Photographic copy of construction drawing, dated 11/30/1927, approved 12/29/1927, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

34. Photographic copy of construction drawing, dated 11/30/1927, approved 12/29/1927, in possession of SCIP Office, Coolidge, AZ. United States Indian Service, Irrigation. PROPOSED CONDUIT - San Carlos Irrigation Project, Sacaton Dam & Bridge, Gila River, T4S R6E S12/13, Coolidge, Pinal County, AZ

195

Cloning, expression, and characterization of a new xylanase from alkalophilic Paenibacillus sp. 12-11.  

PubMed

A xylanase gene, xyn7c, was cloned from Paenibacillus sp. 12-11, an alkalophilic strain isolated from the alkaline wastewater sludge of a paper mill, and expressed in Escherichia coli. The full-length gene consists of 1,296 bp and encodes a mature protein of 400 residues (excluding the putative signal peptide) that belongs to the glycoside hydrolase family 10. The optimal pH of the purified recombinant XYN7C was found to be 8.0, and the enzyme had good pH adaptability at 6.5-8.5 and stability over a broad pH range of 5.0-11.0. XYN7C exhibited maximum activity at 55 degrees C and was thermostable at 50 degrees C and below. Using wheat arabinoxylan as the substrate, XYN7C had a high specific activity of 1,886 U/mg, and the apparent Km and Vmax values were 1.18 mg/ml and 1,961 ?mol/mg/min, respectively. XYN7C also had substrate specificity towards various xylans, and was highly resistant to neutral proteases. The main hydrolysis products of xylans were xylose and xylobiose. These properties make XYN7C a promising candidate to be used in biobleaching, baking, and cotton scouring processes. PMID:21876378

Zhao, Yanyu; Meng, Kun; Luo, Huiying; Yang, Peilong; Shi, Pengjun; Huang, Huoqing; Bai, Yingguo; Yao, Bin

2011-08-01

196

Reactivity of aluminum cluster anions with ammonia: selective etching of Al11(-) and Al12(-).  

PubMed

Reactivity of aluminum cluster anions toward ammonia was studied via mass spectrometry. Highly selective etching of Al(11)(-) and Al(12)(-) was observed at low concentrations of ammonia. However, at sufficiently high concentrations of ammonia, all other sizes of aluminum cluster anions, except for Al(13)(-), were also observed to deplete. The disappearance of Al(11)(-) and Al(12)(-) was accompanied by concurrent production of Al(11)NH(3)(-) and Al(12)NH(3)(-) species, respectively. Theoretical simulations of the photoelectron spectrum of Al(11)NH(3)(-) showed conclusively that its ammonia moiety is chemisorbed without dissociation, although in the case of Al(12)NH(3)(-), dissociation of the ammonia moiety could not be excluded. Moreover, since differences in calculated Al(n)(-) + NH(3) (n=9-12) reaction energies were not able to explain the observed selective etching of Al(11)(-) and Al(12)(-), we concluded that thermodynamics plays only a minor role in determining the observed reactivity pattern, and that kinetics is the more influential factor. In particular, the conversion from the physisorbed Al(n)(-)(NH(3)) to chemisorbed Al(n)NH(3)(-) species is proposed as the likely rate-limiting step. PMID:19916602

Grubisic, Andrej; Li, Xiang; Gantefoer, Gerd; Bowen, Kit H; Schnöckel, Hansgeorg; Tenorio, Francisco J; Martinez, Ana

2009-11-14

197

Conversion of 10-bromo-10,11-dihydrocinchonidine into 8-oxa-1-azabicyclo64.3.09nonane derivatives and related compounds: a structural study  

NASA Astrophysics Data System (ADS)

The structure of dehydrobromination products of 10-bromo-10,11-dihydrocinchonidine 2c has been investigated in order to explore the scope of the conversions so far observed for quinine and cinchonine. The 2c rearranges into a mixture of 4( S)-( E-propenyl)-6( S),7( R)-(quinol-4-yl)-8-oxa-1( R)-azabicyclo[4.3.0]nonane 6 and its Z-propenyl diastereomer 8 in the ratio 3: 1 and also provides Z-3,10-didehydro-10,11-dihydrocinchonidine 18. The mixture of 6 and 8 undergoes catalytic hydrogenation giving 4( S)-propylo-6( S),7( R)-(quinol-4-yl)-8-oxa-1( R)-azabicyclo[4.3.0]nonane 10. On treatment with an acid the alkaloid 6 yields [4( S)- E-propenyl-2( S)-piperidinyl]-4-quinoline ?( R)-methanol 14. Its side chain undergoes hydrogenation affording 4( S)-propylo-derivative 12 which also forms on treatment of 10 by acid. The alkaloids 6, 8, 10, 12 and 14 appear as dominating conformers in their equilibrium mixtures.

Desperak, Danuta; Paw?owski, Jacek; Thiel, Jacek

2004-11-01

198

10 CFR 784.12 - Terms and conditions of waivers.  

...12 Energy DEPARTMENT OF ENERGY PATENT WAIVER REGULATION § 784.12 Terms...conditions for waivers are set forth in the “Patent Rights—Waiver” clause in this section. A waiver of all foreign and domestic patent rights under a contract...

2014-01-01

199

Antagonistic regulation of neurite morphology through Gq/G11 and G12/G13.  

PubMed

The induction of neurite retraction and growth cone collapse via G-protein-coupled receptors is involved in developmental as well as regenerative processes. The role of individual G-protein-mediated signaling processes in the regulation of neurite morphology is still incompletely understood. Using primary neurons from brains lacking Galpha(q)/Galpha(11) or Galpha(12)/Galpha(13), we show here that G(12)/G(13)-mediated signaling is absolutely required for neurite retraction and growth cone collapse induced by the blood-borne factors lysophosphatidic acid and thrombin. Interestingly, the effects of lysophosphatidic acid were mediated mainly by G(13), whereas thrombin effects required G(12). Surprisingly, lack of Galpha(q)/Galpha(11) resulted in overshooting responses to both stimuli, indicating that G(q)/G(11)-mediated signaling most likely via activation of Rac antagonizes the effects of G(12)/G(13). PMID:18854320

Nürnberg, Alexander; Braüer, Anja U; Wettschureck, Nina; Offermanns, Stefan

2008-12-19

200

t10c12-CLA maintains higher bone mineral density during aging by modulating osteoclastogenesis and bone marrow adiposity  

PubMed Central

Conjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism. Earlier, we showed that CLA (equal mixture of c9t11-CLA and t10c12-CLA) could protect age-associated bone loss by modulating inflammatory markers and osteoclastogenesis. Since, c9t11-CLA and t10c12-CLA isomers differentially regulate functional parameters and gene expression in different cell types, we examined the efficacy of individual CLA isomers against age-associated bone loss using 12 months old C57BL/6 female mice fed for 6 months with 10% corn oil (CO), 9.5% CO + 0.5% c9t11-CLA, 9.5% CO + 0.5% t10c12-CLA or 9.5% CO + 0.25% c9t11-CLA + 0.25% t10c12-CLA. Mice fed a t10c12-CLA diet maintained a significantly higher bone mineral density (BMD) in femoral, tibial and lumbar regions than those fed CO and c9t11-CLA diets as measured by dual-energy-x-ray absorptiometry (DXA). The increased BMD was accompanied by a decreased production of osteoclastogenic factors i.e. RANKL, TRAP5b, TNF-alpha and IL-6 in serum. Moreover, a significant reduction of high fat diet-induced bone marrow adiposity was observed in t10c12-CLA fed mice as compared to that of CO and c9t11-CLA fed mice, as measured by Oil-Red-O staining of bone marrow sections. In addition, a significant reduction of osteoclast differentiation and bone resorbing pit formation was observed in t10c12-CLA treated RAW 264.7 cell culture stimulated with RANKL as compared to that of c9t11-CLA and linoleic acid treated cultures. In conclusion, these findings suggest that t10c12-CLA is the most potent CLA isomer and it exerts its anti-osteoporotic effect by modulating osteoclastogenesis and bone marrow adiposity.

Rahman, M; Halade, Ganesh V; Williams, Paul J; Fernandes, Gabriel

2011-01-01

201

12 CFR 1207.10-1207.19 - [Reserved  

Code of Federal Regulations, 2013 CFR

...10-1207.19 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS MINORITY AND WOMEN INCLUSION Minority and Women Inclusion and Diversity at the Federal Housing Finance Agency § 1207.10-1207.19...

2013-01-01

202

12 CFR 1207.10 - through 1207.19 [Reserved  

Code of Federal Regulations, 2012 CFR

...1207.10 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS MINORITY AND WOMEN INCLUSION Minority and Women Inclusion and Diversity at the Federal Housing Finance Agency § 1207.10 through 1207.19...

2012-01-01

203

12 CFR 327.10 - Assessment rate schedules.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Assessment rate schedules. 327.10 Section 327...ASSESSMENTS In General § 327.10 Assessment rate schedules. (a) Initial Base Assessment Rate Schedule. The initial base...

2010-01-01

204

12 CFR 327.10 - Assessment rate schedules.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 2009-01-01 false Assessment rate schedules. 327.10 Section...ASSESSMENTS In General § 327.10 Assessment rate schedules. (a) Base Assessment Schedule. The base annual assessment rate for an insured depository...

2009-01-01

205

Hierarchical fragmentation and differential star formation in the Galactic `Snake': infrared dark cloud G11.11-0.12  

NASA Astrophysics Data System (ADS)

We present Submillimeter Array (SMA) ? = 0.88 and 1.3 mm broad-band observations, and Very Large Array (VLA) observations in NH3 (J, K) = (1,1) up to (5,5), H2O and CH3OH maser lines towards the two most massive molecular clumps in infrared dark cloud (IRDC) G11.11-0.12. Sensitive high-resolution images reveal hierarchical fragmentation in dense molecular gas from the ˜1 pc clump scale down to ˜0.01 pc condensation scale. At each scale, the mass of the fragments is orders of magnitude larger than the Jeans mass. This is common to all four IRDC clumps we studied, suggesting that turbulence plays an important role in the early stages of clustered star formation. Masers, shock heated NH3 gas, and outflows indicate intense ongoing star formation in some cores while no such signatures are found in others. Furthermore, chemical differentiation may reflect the difference in evolutionary stages among these star formation seeds. We find NH3 ortho/para ratios of 1.1 ± 0.4, 2.0 ± 0.4, and 3.0 ± 0.7 associated with three outflows, and the ratio tends to increase along the outflows downstream. Our combined SMA and VLA observations of several IRDC clumps present the most in-depth view so far of the early stages prior to the hot core phase, revealing snapshots of physical and chemical properties at various stages along an apparent evolutionary sequence.

Wang, Ke; Zhang, Qizhou; Testi, Leonardo; Tak, Floris van der; Wu, Yuefang; Zhang, Huawei; Pillai, Thushara; Wyrowski, Friedrich; Carey, Sean; Ragan, Sarah E.; Henning, Thomas

2014-04-01

206

Molecular cytogenetic analysis of 10;11 rearrangements in acute myeloid leukemia  

Microsoft Academic Search

MLLT10 (previously called AF10) is a moderately common MLL fusion partner predominantly occurring in acute monoblastic leukemia (AML-M5). 10;11 rearrangements require at least three breaks in order to generate an in-frame MLL-MLLT10 fusion as a result of the opposite orientations of both genes on the respective chromosome arms. In this study, we describe a detailed molecular cytogenetic analysis of MLL-MLLT10

H Van Limbergen; B Poppe; A Janssens; R De Bock; A De Paepe; L Noens; F Speleman

2002-01-01

207

12 CFR 508.10 - Burden of persuasion.  

Code of Federal Regulations, 2010 CFR

... 5 2010-01-01 2010-01-01 false Burden of persuasion. 508.10 Section 508.10 Banks and Banking OFFICE...WHERE A CRIME IS CHARGED OR PROVEN § 508.10 Burden of persuasion. The petitioner has the burden of showing, by a...

2010-01-01

208

Novel Susceptibility Variants at 10p12.31-12.2 for Childhood Acute Lymphoblastic Leukemia in Ethnically Diverse Populations  

PubMed Central

Background Acute lymphoblastic leukemia (ALL) is the most common cancer in children and the incidence of ALL varies by ethnicity. Although accumulating evidence indicates inherited predisposition to ALL, the genetic basis of ALL susceptibility in diverse ancestry has not been comprehensively examined. Methods We performed a multiethnic genome-wide association study in 1605 children with ALL and 6661 control subjects after adjusting for population structure, with validation in three replication series of 845 case subjects and 4316 control subjects. Association was tested by two-sided logistic regression. Results A novel ALL susceptibility locus at 10p12.31-12.2 (BMI1-PIP4K2A, rs7088318, P = 1.1×10?11) was identified in the genome-wide association study, with independent replication in European Americans, African Americans, and Hispanic Americans (P = .001, .009, and .04, respectively). Association was also validated at four known ALL susceptibility loci: ARID5B, IKZF1, CEBPE, and CDKN2A/2B. Associations at ARID5B, IKZF1, and BMI1-PIP4K2A variants were consistent across ethnicity, with multiple independent signals at IKZF1 and BMI1-PIP4K2A loci. The frequency of ARID5B and BMI1-PIP4K2A variants differed by ethnicity, in parallel with ethnic differences in ALL incidence. Suggestive evidence for modifying effects of age on genetic predisposition to ALL was also observed. ARID5B, IKZF1, CEBPE, and BMI1-PIP4K2A variants cumulatively conferred strong predisposition to ALL, with children carrying six to eight copies of risk alleles at a ninefold (95% confidence interval = 6.9 to 11.8) higher ALL risk relative to those carrying zero to one risk allele at these four single nucleotide polymorphisms. Conclusions These findings indicate strong associations between inherited genetic variation and ALL susceptibility in children and shed new light on ALL molecular etiology in diverse ancestry.

2013-01-01

209

10 CFR 1046.12 - Physical fitness training program.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 2009-01-01 false Physical fitness training program. 1046...Force Personnel § 1046.12 Physical fitness training program. (a...who has not met the applicable physical fitness qualification standard,...

2009-01-01

210

10 CFR 1046.12 - Physical fitness training program.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Physical fitness training program. 1046...Force Personnel § 1046.12 Physical fitness training program. (a...who has not met the applicable physical fitness qualification standard,...

2010-01-01

211

10 CFR 1046.12 - Physical fitness training program.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Physical fitness training program. 1046...OF ENERGY (GENERAL PROVISIONS) PHYSICAL PROTECTION OF SECURITY INTERESTS...Force Personnel § 1046.12 Physical fitness training program....

2011-01-01

212

10 CFR 1046.12 - Physical fitness training program.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Physical fitness training program. 1046...OF ENERGY (GENERAL PROVISIONS) PHYSICAL PROTECTION OF SECURITY INTERESTS...Force Personnel § 1046.12 Physical fitness training program....

2012-01-01

213

10 CFR 1046.12 - Physical fitness training program.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Physical fitness training program. 1046...OF ENERGY (GENERAL PROVISIONS) PHYSICAL PROTECTION OF SECURITY INTERESTS...Force Personnel § 1046.12 Physical fitness training program....

2013-01-01

214

Fast Data Transfer System between PDP11/10 and SM-4 Computers.  

National Technical Information Service (NTIS)

A fast data transfer up to 250 Kbytes/sec is described. The system allows fast data transfer between PDP11/10 minicomputer, which works as a CADOS (a data acquisition system) control unit, and SM-4 (PDP11/40 compatible) in any direction. The data transfer...

W. Kantor

1985-01-01

215

An Investigation into Understanding of Geological Time among 10- and 11-Year-Old Children.  

ERIC Educational Resources Information Center

Focuses on the understanding of British children (N=189) of geologic time as they participate in related activities. Indicates that 10- and 11-year-old children lack a clear chronology of geologic events. Contains 22 references. (DDR)

Trend, Roger

1998-01-01

216

43 CFR 10.11 - Disposition of culturally unidentifiable human remains.  

Code of Federal Regulations, 2013 CFR

...Objects, or Objects of Cultural Patrimony in Museums and Federal Collections § 10.11 ...identified. (b) Consultation. (1) The museum or Federal agency official must initiate...associated funerary objects. (2) The museum or Federal agency official must...

2013-10-01

217

Photograph of photogrammetric plate LCHABSGS11IL1124S10R. EAST (WELLS STREET) ELEVATION, UPPER ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Photograph of photogrammetric plate LC-HABS-GS11-IL-1124-S10R. EAST (WELLS STREET) ELEVATION, UPPER LEVEL Middle left section of elevation - Phelps-Dodge-Palmer Building, 200 West Adams Street, Chicago, Cook County, IL

218

Gas-phase conformations and exciton couplings in 5,6,11,12-tetrahydrodibenzo[ a , e ]cyclooctene  

Microsoft Academic Search

The conformations and exciton couplings in 5,6,11,12-tetrahydrodibenzo[a,e]cyclooctene (THDC) have been studied using resonance-enhanced two-photon ionization spectroscopy in a supersonic jet expansion.\\u000a It has been estimated from the spectral analysis that 90% of THDC exists in the twist-boat (TB) conformation; the chair (C)\\u000a conformer constitutes the remaining 10%. Most of the vibronic activity in the spectrum of THDC is associated with

Abdulhamid Hamza

2010-01-01

219

Solution Structure of CCP Modules 10-12 Illuminates Functional Architecture of the Complement Regulator, Factor H  

PubMed Central

The 155-kDa plasma glycoprotein factor H (FH), which consists of 20 complement control protein (CCP) modules, protects self-tissue but not foreign organisms from damage by the complement cascade. Protection is achieved by selective engagement of FH, via CCPs 1–4, CCPs 6–8 and CCPs 19–20, with polyanion-rich host surfaces that bear covalently attached, activation-specific, fragments of complement component C3. The role of intervening CCPs 9–18 in this process is obscured by lack of structural knowledge. We have concatenated new high-resolution solution structures of overlapping recombinant CCP pairs, 10–11 and 11–12, to form a three-dimensional structure of CCPs 10–12 and validated it by small-angle X-ray scattering of the recombinant triple?module fragment. Superimposing CCP 12 of this 10–12 structure with CCP 12 from the previously solved CCP 12–13 structure yielded an S-shaped structure for CCPs 10–13 in which modules are tilted by 80–110° with respect to immediate neighbors, but the bend between CCPs 10 and 11 is counter to the arc traced by CCPs 11–13. Including this four-CCP structure in interpretation of scattering data for the longer recombinant segments, CCPs 10–15 and 8–15, implied flexible attachment of CCPs 8 and 9 to CCP 10 but compact and intimate arrangements of CCP 14 with CCPs 12, 13 and 15. Taken together with difficulties in recombinant production of module pairs 13–14 and 14–15, the aberrant structure of CCP 13 and the variability of 13–14 linker sequences among orthologues, a structural dependency of CCP 14 on its neighbors is suggested; this has implications for the FH mechanism.

Makou, Elisavet; Mertens, Haydyn D.T.; Maciejewski, Mateusz; Soares, Dinesh C.; Matis, Ilias; Schmidt, Christoph Q.; Herbert, Andrew P.; Svergun, Dmitri I.; Barlow, Paul N.

2012-01-01

220

Matrix metalloproteinase-2 is involved in A549 cell migration on laminin-10/11.  

PubMed

We have reported that laminin-10/11 strongly promotes migration of A549 human lung carcinoma cells by activating the alpha3beta1 integrin-dependent signaling pathway. To elucidate the mechanism involved, we investigated whether matrix metalloproteinases (MMPs) are involved in cell migration on laminin-10/11. Here, we demonstrate that laminin-10/11, but not fibronectin which does not greatly promote A549 cell movement, stimulated MMP-2 secretion approximately 3-fold. The cell migration-promoting activity of laminin-10/11 was down-regulated by an MMP inhibitor. In addition, cell motility was significantly increased when cells adhered to a mixture of fibronectin and laminin-10/11 with a concomitant decrease of focal contacts, compared with those adhering to fibronectin alone. The enhanced cell migration was partially suppressed by the MMP inhibitor. Furthermore, an anti-alpha3 integrin, but not an anti-alpha5 integrin, antibody induced the activated form of MMP-2. These data suggest that MMP-2 may play an important role in A549 cell migration on laminin-10/11 through an alpha3beta1 integrin-dependent pathway. PMID:12147229

Gu, J; Nishiuchi, R; Sekiguchi, K

2002-08-01

221

Solid state conformational parameters in dibenzo[ b,f ]heteroepin drugs: Crystal structures of 3-methoxy-10-methyl-11-phenyldibenzo[ b, f ]thiepine and 3-allyloxy-10-ethyl-11-phenyldibenzo[ b, f ]oxepine  

Microsoft Academic Search

The structures of 3-methoxy-10-methyl-11-phenyldibenzo[b, f]thiepine (I) [C22H18OS, tetragonal,I41\\/a, witha=33.81(1),c=6.065(5)Å,Z=16] and 3-allyloxy-10-ethyl-11-phenyldibenzo[b,f]oxepine (II) [C25H22O2, mono-clinic,P21\\/c,a=12.115(7),b=16.316(9),c=10.136(7)Å,ß=105.05(9)°,Z=4] have been determined by the symbolic addition procedure and refined by least-squares method to anR of 0.090 for 784 diffractometer-measured reflections (I) and to anR of 0.083 for 442 reflections (II). The dihedral angle between the phenyl-ring mean planes is 111.3° in (I) and 121.1° in

Giuliano Bandoli; Marino Nicolini

1982-01-01

222

34 CFR 12.11 - What statutory provisions and Executive Orders apply to transfers of surplus Federal real property?  

Code of Federal Regulations, 2013 CFR

...of surplus Federal real property? 12.11 Section 12.11 Education Office of the Secretary...Applicable to Transfers or Leases § 12.11 What statutory provisions... (Authority: 40 U.S.C. 484(k)) (Approved by the Office...

2013-07-01

223

The Structure of 12N using 11C + p resonance scattering  

SciTech Connect

The level structure of {sup 12}N has been investigated from 2.2 to 11.0 MeV in excitation energy using a {sup 11}C + p resonance interaction with thick targets and inverse kinematics. Excitation functions were fitted using an R-matrix approach. Sixteen levels in {sup 12}N were included in the analysis, several of them are new. Spin-parity assignments, excitation energies and widths are proposed for these levels. To fit the high energy part of the excitation function, imaginary phase shifts had to be added to the phase shifts generated by the hard sphere scattering.

Perajarvi, K.; Chang, Bo Fu; Rogachev, G.V.; Chubarian, G.; Goldberg, V.Z.; Guo, Q.; Lee, D.; Moltz, D.M.; Powell, J.; Skorodumov,B.B.; Tabacaru, G.; Tang, X.D.; Tribble, R.E.; Brown, B.A.; Volya, A.; Cerny, Joseph

2006-03-02

224

12 CFR 1209.10 - Authority of the Director.  

Code of Federal Regulations, 2012 CFR

...and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS RULES OF PRACTICE AND PROCEDURE Rules of Practice and Procedure § 1209.10 Authority of the Director. The Director may, at any time during the pendency...

2012-01-01

225

12 CFR 1777.10 - Developments prompting supervisory response.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Developments prompting supervisory response. ...OVERSIGHT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SAFETY AND SOUNDNESS PROMPT CORRECTIVE...Supervisory Response § 1777.10 Developments prompting supervisory response....

2013-01-01

226

Biotransformation of 2,4,6,8,10,12-Hexanitro- 2,4,6,8,10,12- Hexaazaisowurtzitane (CL-20) by Denitrifying Pseudomonas sp. Strain FA1.  

National Technical Information Service (NTIS)

The microbial and enzymatic degradation of a new energetic compound, 2,4,6,8,10,12-hexanitro- 2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), is not well understood. Fundamental knowledge about the mechanism of microbial degradation of CL-20 is essential to a...

B. Bhushan J. Hawari J. C. Spain L. Paquet

2003-01-01

227

Results of Pioneer 10 and 11 Meteoroid Experiments: Interplanetary and Near-Saturn  

Microsoft Academic Search

The meteoroid penetration detectors on Pioneer 10 (channel 0) recorded 95 penetrations through the 25-tm stainless steel test material while the spacecraft was between 1 and 18 AU. The spatial density of 10-9g meteoroids is found to be essentially constant between 1 and 18 AU. The meteoroid penetration detectors on Pioneer 11 recorded 87 penetrations (55 on channel 0 and

D. H. Humes

1980-01-01

228

10 Years of Media Literacy Education in K-12 Schools  

ERIC Educational Resources Information Center

When the author started working with teachers and students on classroom multimedia productions a little over 10 years ago, he had not yet encountered the term "media literacy", nor did he realize he had joined a long standing international movement of media literacy educators. Serendipitous exposure to "old-media" texts by Neil Postman and Noam…

Daunic, Rhys

2011-01-01

229

12 CFR 1320.10 - Factors for consideration in designations.  

Code of Federal Regulations, 2013 CFR

... 2013-01-01 false Factors for consideration in designations...and Hearings § 1320.10 Factors for consideration in designations...tiering; and (6) Potential impact or spillover in the event of...disruption. (e) Any other factors that the Council deems...

2013-01-01

230

Aluminum Leaching of ''Archived'' Sludge from Tanks 8F, 11H, and 12H  

SciTech Connect

Aluminum can promote formation or dissolution of networks in hydroxide solid solutions. When present in large amounts it will act as a network former increasing both the viscosity and the surface tension of melts. This translates into poor free flow properties that affect pour rate of glass production in the Defense Waste Processing Facility (DWPF). To mitigate this situation, DWPF operations limit the amount of aluminum contained in sludge. This study investigated the leaching of aluminum compounds from archived sludge samples. The conclusions found boehmite present as the predominant aluminum compound in sludge from two tanks. We did not identify an aluminum compound in sludge from the third tank. We did not detect any amorphous aluminum hydroxide in the samples. The amount of goethite measured 4.2 percentage weight while hematite measured 3.7 percentage weight in Tank 11H sludge. The recommended recipe for removing gibbsite in sludge proved inefficient for digesting boehmite, removing less than 50 per cent of the compound within 48 hours. The recipe did remove boehmite when the test ran for 10 days (i.e., 7 more days than the recommended baseline leaching period). Additions of fluoride and phosphate to Tank 12H archived sludge did not improve the aluminum leaching efficiency of the baseline recipe.

FONDEUR, FERNANDOF.

2004-03-12

231

Units 11 - 12 - Reference Manual for People & Animals: United for Health  

NSDL National Science Digital Library

This section contains two Units plus the Glossary and Index: Unit 11 - What Is MSMR? Unit 12 - Careers in Health and Health Research Glossary of Terms Used Index Each unit provides clear and comprehensive information, illustrations and slides (contained in a separate archive file in this collection) that is very helpful in developing a curriculum.

Dr. Leslie Nader (MSMR)

1992-07-01

232

HISTORY OF THE LANGUAGE, MATERIAL FOR INCORPORATION IN CURRICULA OF GRADES 11 AND 12.  

ERIC Educational Resources Information Center

THIS CURRICULUM GUIDE, A PRODUCT OF NORTHERN ILLINOIS UNIVERSITY'S PROJECT ENGLISH CENTER, CONSISTS OF FOUR UNITS TO BE INCORPORATED INTO THE CURRICULA OF GRADES 11 AND 12--(1) THE HISTORY OF THE SOUNDS OF ENGLISH, (2) THE DEVELOPMENT OF THE GRAMMATICAL SIGNALS OF MODERN ENGLISH, (3) THE HISTORICAL DEVELOPMENT OF ENGLISH SPELLING, AND (4)…

Northern Illinois Univ., De Kalb. Project English Curriculum Center.

233

Australian Chemistry Test Item Bank: Years 11 and 12. Volume 2.  

ERIC Educational Resources Information Center

The second volume of the Australian Chemistry Test Item Bank, consisting of two volumes, contains nearly 2000 multiple-choice items related to the chemistry taught in Year 11 and Year 12 courses in Australia. Items which were written during 1979 and 1980 were initially published in the "ACER Chemistry Test Item Collection" and in the "ACER…

Commons, C., Ed.; Martin, P., Ed.

234

Cavity-stabilized laser with acceleration sensitivity below 10-12 g-1  

NASA Astrophysics Data System (ADS)

We characterize the frequency sensitivity of a cavity-stabilized laser to inertial forces and temperature fluctuations, and perform real-time feedforward to correct for these sources of noise. We measure the sensitivity of the cavity to linear accelerations, rotational accelerations, and rotational velocities by rotating it about three axes with accelerometers and gyroscopes positioned around the cavity. The worst-direction linear acceleration sensitivity of the cavity is 2(1)×10-11 g-1 measured over 0-50 Hz, which is reduced by a factor of 50 to below 10-12 g-1 for low-frequency accelerations by real-time feedforward corrections of all of the aforementioned inertial forces. A similar idea is demonstrated in which laser frequency drift due to temperature fluctuations is reduced by a factor of 70 via real-time feedforward from a temperature sensor located on the outer wall of the cavity vacuum chamber.

Leibrandt, David R.; Bergquist, James C.; Rosenband, Till

2013-02-01

235

Duplication of chromosome band 12q24.11q24.23 results in apparent Noonan syndrome.  

PubMed

Noonan syndrome is an autosomal dominant disorder with an estimated incidence of 1 in 1,000 to 1 in 2,500 live births. It is characterized by postnatal-onset short stature, characteristic facial changes, webbed neck, pectus carinatum, or excavatum, congenital heart defects, and bleeding abnormalities. Gain-of-function mutations in the PTPN11, KRAS, SOS1, and RAF1 genes that are components of the RAS/MEPK signaling pathway are identified in about 70-85% of individuals with Noonan syndrome. We report here a case of duplication of chromosome region 12q24.11q24.23 identified by array comparative genomic hybridization (aCGH) that includes the PTPN11 gene in a 3-year-old girl with apparent Noonan syndrome. The patient presented with postnatal-onset failure-to-thrive, developmental delay, microcephaly, velopalatal incompetence, pectus excavatum, coarctation of aorta, atrial and ventricular septal defects, decreased muscle tone, and minor facial anomalies consistent with Noonan syndrome. At 3 years of age her speech, gross and fine motor development were at the level of a 12-18 month old child. This degree of developmental delay was atypical for an individual with Noonan syndrome, raising concerns for a chromosomal abnormality. Array-CGH showed an interstitial duplication of 10 Mb including the PTPN11 gene. Sequencing of PTPN11, KRAS, SOS1 and the coding region of RAF1 did not identify mutations. The increased gene dosage of the PTPN11 gene in the form of duplication is expected to have the same consequence as gain-of-function mutations seen in Noonan syndrome. We propose that at least some of the 15-30% of individuals with Noonan syndrome who do not have a mutation by sequencing may have a gain in copy number of PTPN11 and recommend that comprehensive testing for Noonan syndrome should include analysis for copy number changes of PTPN11. PMID:18348260

Shchelochkov, Oleg A; Patel, Ankita; Weissenberger, George M; Chinault, A Craig; Wiszniewska, Joanna; Fernandes, Priscilla H; Eng, Christine; Kukolich, Mary K; Sutton, V Reid

2008-04-15

236

Cubic phases in hydrated 1:1 and 1:2 dipalmitoylphosphatidylcholine-dipalmitoylglycerol mixtures.  

PubMed Central

The structures of fully hydrated 1:1 and 1:2 (mol/mol) dipalmitoylphosphatidylcholine (DPPC)-dipalmitoylglycerol (DPG) mixtures were studied by means of small-angle x-ray diffraction. The x-ray diffraction pattern of the 1:1 (mol/mol) DPPC-DPG mixture at 65 degrees C contains three reflections with spacings in the ratio of 1:1/ square root of 2:1/ square root of 3 in addition to reflections of an inverted hexagonal (H11) phase. A possible interpretation of this result is that a cubic phase of the body-centered space group lm3m, with a lattice constant of 23.1 +/- 0.6 nm, is formed. This cubic phase appears at intermediate temperatures between the lamellar and the H11 phases. The 1:2 (mol/mol) DPPC-DPG mixture gives an x-ray diffraction pattern at temperatures higher than the lamellar-to-H11 transition containing a number of reflections that index a cubic phase structure. The space group of the cubic phase was assigned a face-centered group Fd3m with a lattice constant of 16.3 +/- 0.1 nm at 82 degrees C. The possible role of cubic phases in membrane phenomena such as transmembrane signal transduction and fusion is discussed.

Takahashi, H; Hatta, I; Quinn, P J

1996-01-01

237

The Sequential Growth of Star Formation Seeds in the Galactic Snake: Infrared Dark Cloud G11.11-0.12  

NASA Astrophysics Data System (ADS)

We present Submillimeter Array (SMA) 1.3 and 0.88 mm broad band observations, and Very Large Array (VLA) observations in NH3 (J,K) = (1,1) up to (5,5), as well as H2O and CH3OH maser lines toward the two most massive molecular clumps in Infrared Dark Cloud (IRDC) G11.11-0.12, also known as the Snake nebula. The sensitive high-resolution images reveal hierarchical fragmentation from the ~1pc clump scale down to ~0.01pc condensation scale. At each fragmenting scale, the mass of the fragments is orders of magnitude larger than the Jeans mass. This is common to all four IRDC clumps we studied, suggesting that turbulence plays a dominant role in the initial stages of clustered star formation. Masers, shock heated NH3 gas, and outflows indicate intense ongoing star formation in some cores while none of such signatures are found in others. Furthermore, chemical differentiation between cores reflects a sequential growth of these star formation seeds. The same applies to condensations and clumps. The mass function of the resolved condensations is consistent with a power law with an index of alpha = 2.0+/-0.2 and a turnover at 2.7 solar mass. Our combined SMA+VLA observations of several IRDC clumps have presented so far the deepest view of the early stages prior to the hot core phase, revealing snapshots of physical and chemical properties at various stages along an apparent evolutionary sequence, subject to further tests by detailed modeling.

Wang, Ke; Zhang, Qizhou; Testi, Leonardo; Wu, Yuefang; Zhang, Huawei; van der Tak, Floris; Pillai, Thushara; Wyrowski, Friedrich; Carey, Sean; Ragan, Sarah; Henning, Thomas

2013-07-01

238

Subbarrier fusion in the systems 11,10Be+ 209Bi  

Microsoft Academic Search

The subbarrier fusion cross sections with radioactive ion beams in the systems 10,11Be+209Bi have been measured and compared also with the stable system 9Be+209Bi. All three cross sections are similar within experimental accuracy; this is somehow unexpected since, in particular, the fusion process with 11Be should be influenced by its halo structure and small binding energy and could behave in

C. Signorini; A. Yoshida; Y. Watanabe; D. Pierroutsakou; L. Stroe; T. Fukuda; M. Mazzocco; N. Fukuda; Y. Mizoi; M. Ishihara; H. Sakurai; A. Diaz-Torres; K. Hagino

2004-01-01

239

40 CFR 180.1086 - 3,7,11-Trimethyl-1,6,10-dodecatriene-1-ol and 3,7,11-trimethyl-2,6,10-dodecatriene-3-ol...  

Code of Federal Regulations, 2013 CFR

...and 3,7,11-trimethyl-2,6,10-dodecatriene-3-ol; exemption from the requirement of a tolerance. The insect pheromone containing the active ingredients 3,7,11-trimethyl-1,6,10-dodecatriene-1-ol and...

2013-07-01

240

Magnetoelectric response of AlN/[(Fe90Co10)78Si12B10 + Terfenol-D] composite films  

NASA Astrophysics Data System (ADS)

The magnetoelectric (ME) composite films composed of piezoelectric layer AlN film and new magnetostrictive layer [(Fe90Co10)78Si12B10 + Terfenol-D] films were successfully prepared by RF magnetron sputtering. The influence of bias magnetic field Hdc on ME response, as well as, the ac magnetic field sensitivity were investigated in detail. The results demonstrated that the respective magnetic properties of (Fe90Co10)78Si12B10 and Terfenol-D films are coupled in this new magnetostrictive layer, resulting in the fact that ME voltage coefficient ?ME reaches the maximum of 78.1 V/cm Oe and 77.5 V/cm Oe at the bias field of 11 Oe and 96 Oe, respectively. Meanwhile, the composite films display ac magnetic field sensitivity of 0.45 nT/?Hz and 0.47 nT/?Hz at Hdc of 11 Oe and 96 Oe, respectively. The results above indicate that the AlN/[(Fe90Co10)78Si12B10 + Terfenol-D] composite films exhibit a promising potential application in diverse range of magnetic field detection.

Tong, Bei; Yang, Xiaofei; Ouyang, Jun; Lin, Gengqi; Zhang, Yue; Chen, Shi

2014-05-01

241

Large scale temporal and radial gradients in the IMF - Helios 1, 2, ISEE-3, and Pioneer 10, 11  

NASA Technical Reports Server (NTRS)

Recent investigations using measurements at 1 AU have discovered three types of long term variation in the interplanetary magnetic field: solar minimum decreases, solar maximum enhancements, and small decreases around solar reversal. In this study the 1972-1982 Helios 1, 2, ISEE-3, and Pioneer 10, 11 observations between 0.3 and 12 AU are examined to further investigate these changes. It was found that all three IMF solar cycle effects are also present in the Helios and Pioneer measurements, confirming that these variations occur throughout the low latitude heliosphere. In addition, the comparison of measurements by identical magnetometers on ISEE-3, Pioneer 10 and Pioneer 11 has revealed a more rapid decrease in IMF intensity than predicted by classical Parker theory. Causes and ramifications of both the long term variations and steeper-than-expected radial gradients in the interplanetary magnetic field are discussed.

Slavin, J. A.; Smith, E. J.; Thomas, B. T.

1984-01-01

242

AzTEC 1.1 mm OBSERVATIONS OF THE MBM12 MOLECULAR CLOUD  

SciTech Connect

We present 1.1 mm observations of the dust continuum emission from the MBM12 high-latitude molecular cloud observed with the Astronomical Thermal Emission Camera (AzTEC) mounted on the James Clerk Maxwell Telescope on Mauna Kea, Hawaii. We surveyed 6.34 deg{sup 2} centered on MBM12, making this the largest area that has ever been surveyed in this region with submillimeter and millimeter telescopes. Eight secure individual sources were detected with a signal-to-noise ratio of over 4.4. These eight AzTEC sources can be considered to be real astronomical objects compared to the other candidates based on calculations of the false detection rate. The distribution of the detected 1.1 mm sources or compact 1.1 mm peaks is spatially anti-correlated with that of the 100 {mu}m emission and the {sup 12}CO emission. We detected the 1.1 mm dust continuum emitting sources associated with two classical T Tauri stars, LkH{alpha}262 and LkH{alpha}264. Observations of spectral energy distributions (SEDs) indicate that LkH{alpha}262 is likely to be Class II (pre-main-sequence star), but there are also indications that it could be a late Class I (protostar). A flared disk and a bipolar cavity in the models of Class I sources lead to more complicated SEDs. From the present AzTEC observations of the MBM12 region, it appears that other sources detected with AzTEC are likely to be extragalactic and located behind MBM12. Some of these have radio counterparts and their star formation rates are derived from a fit of the SEDs to the photometric evolution of galaxies in which the effects of a dusty interstellar medium have been included.

Kim, M. J.; Kim, S.; Youn, S.; Kang, Y.-W. [Department of Astronomy and Space Science, Sejong University, KwangJin-gu, KunJa-dong 98, Seoul 143-747 (Korea, Republic of); Yun, M. S.; Wilson, G. W. [Department of Astronomy, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (United States); Aretxaga, I.; Hughes, D. H.; Humphrey, A. [Instituto Nacional de Astrofisca, Optica y Electronica, Tonantzintla, Puebla (Mexico); Williams, J. P. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Austermann, J. E. [Department of Astrophysical and Planetary Sciences, University of Colorado, Boulder, Colorado 80309 (United States); Perera, T. A. [Department of Physics, Illinois Wesleyan University, Bloomington, IL 61701 (United States); Mauskopf, P. D. [School of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA (United Kingdom); Magnani, L., E-mail: sek@sejong.ac.kr [Department of Physics and Astronomy, The University of Georgia, Athens, GA 30602-2451 (United States)

2012-02-10

243

Detection of a pathway from linoleate to a novel cyclopentenone: cis-12-oxo-10-phytoenoic acid in sunflower roots.  

PubMed

The lipoxygenase pathway in sunflower roots was studied in vitro. A preliminary incubation of linoleic acid with 15 000 g supernatant of homogenate of sunflower roots (1.5-6 days after germination) revealed the predominant activity of 13-lipoxygenase. The exogenously added linoleic acid 13-hydroperoxide is further utilized through two competing pathways. One of them is directed towards formation of the ketodiene (9Z,11E)-13-oxooctadeca-9,11-dienoic acid. The second pathway, which is controlled by allene oxide synthase, leads to the formation of an alpha-ketol and a novel cyclopentenone, rac-cis-12-oxo-10-phytoenoic acid (12-oxo-PEA) via a short-lived allene oxide. Unexpectedly, the cyclopentenone 12-oxo-PEA is the predominant allene oxide synthase product. Identification of cis-12-oxo-PEA was confirmed by its UV, mass, (1)H NMR and 2D-COSY spectral data. The highest yield of 12-oxo-PEA is observed in very young roots (1.5-2 days after germination). The results of methanol-trapping experiments demonstrate that both 12-oxo-PEA and alpha-ketol are formed through the unstable allene oxide intermediate, (9Z)-12,13-epoxyoctadeca-9,11-dienoic acid, which is the primary product of allene oxide synthase. Since 12-oxo-PEA is a jasmonate congener, its biosynthesis in plants might be of physiological importance. PMID:17957816

Grechkin, Alexander N; Ogorodnikova, Anna V; Gnezdilov, Oleg I; Mukhtarova, Lucia S

2007-12-17

244

Preparation, separation, and confirmation of the eight geometrical cis\\/trans conjugated linoleic acid isomers 8,10-through 11,13–18?2  

Microsoft Academic Search

Conjugated linoleic acid (CLA) mixtures were isomerized with p-toluenesulfinic acid or I2 catalyst. The resultant mixtures of the eight cis\\/trans geometric isomers of 8,10-, 9,11-, 10,12-, and 11,13-octadecadienoic (18?2) acid methyl esters were separated by silver ion-high-performance\\u000a liquid chromatography (Ag+-HPLC) and gas chromatography (GC). Ag+-HPLC allowed the separation of all positional CLA isomers and geometric cis\\/trans CLA isomers except 10,12–18?2.

Klaus Eulitz; Martin P. Yurawecz; Najibullah Sehat; Jan Fritsche; John A. G. Roach; Magdi M. Mossoba; John K. G. Kramer; Richard O. Adlof; Yuoh Ku

1999-01-01

245

46 CFR 52.25-10 - Organic fluid vaporizer generators (modifies PVG-1 through PVG-12).  

Code of Federal Regulations, 2013 CFR

...2013-10-01 2013-10-01 false Organic fluid vaporizer generators (modifies...Other Boiler Types § 52.25-10 Organic fluid vaporizer generators (modifies PVG-1 through PVG-12). (a) Organic fluid vaporizer generators...

2013-10-01

246

A case of acute myelogenous leukemia with MLL-AF10 fusion caused by insertion of 5' MLL into 10p12, with concurrent 3' MLL deletion.  

PubMed

Structural abnormalities involving the mixed-lineage leukemia (MLL) gene on 11q23 have been associated with hematological malignancies. The rearrangement of MLL occurs during translocations and insertions involving a variety of genes on the partner chromosome. We report a rare case of acute myelogenous leukemia (AML-M2) with 11q23 abnormalities. Fluorescence in situ hybridization (FISH) using a commercial dual-color MLL probe detected an atypical signal pattern: one fusion signal, two green signals smaller than those usually detected, and no orange signals. Spectral karyotyping (SKY) analysis indicated that one green signal was detected on the short arm of derivative chromosome 10, and the other green signal on the long arm of a derivative chromosome 11, on which no orange signal was detected. A long-distance inverse polymerase chain reaction (LDI-PCR) identified the fusion partner gene, in which intron 6 of MLL was fused with intron 8 of AF10 on 10p12 in the 5' to 3' direction. Our observations indicated that the MLL-AF10 fusion gene resulted from the insertion of part of the region that included the 5' MLL insertion into 10p12; this was concurrent with the deletion of 3' MLL. PMID:17074587

Matsuda, Kazuyuki; Hidaka, Eiko; Ishida, Fumihiro; Yamauchi, Kazuyoshi; Makishima, Hideki; Ito, Toshiro; Suzuki, Takefumi; Imagawa, Eri; Sano, Kenji; Katsuyama, Tsutomu; Ota, Hiroyoshi

2006-11-01

247

76 FR 45211 - Airworthiness Directives; Honeywell International Inc. TPE331-10 and TPE331-11 Series Turboprop...  

Federal Register 2010, 2011, 2012, 2013

...2009-NE-18-AD] Airworthiness Directives; Honeywell International Inc. TPE331-10 and TPE331-11...directive (AD) supersedure, applicable to Honeywell International Inc. TPE331-10 and TPE331-11...Page 45212

2011-07-28

248

Unbalanced translocation der(11)t(11;12)(q23;q13): a new recurrent cytogenetic aberration in myelodysplastic syndrome with a complex karyotype.  

PubMed

Cytogenetic abnormalities are observed in approximately one half of cases of myelodysplastic syndrome (MDS). Partial or complete chromosome losses and chromosome gains are frequently found, but there is a relatively high incidence of unbalanced translocations in MDS. We describe here two cases of MDS with an unbalanced translocation, der(11)t(11;12)(q23;q13). Both patients were 69 years of age and diagnosed with refractory anemia with excess of blasts in transformation (RAEB-t) according to the high percentage of blasts in the peripheral blood. Cytoplasmic hypogranulation of neutrophils was evident as a dysplastic change. The blasts were positive for CD4 and CD41a as well as CD13, CD33, CD34 and HLA-DR in both cases. Chromosome analysis showed complex karyotypes including a der(11)t(1;11)(q11;p15)t(11;12)(q23;q13) in case 1 and der(11)t(11;12)(q23;q13) in case 2 plus several marker chromosomes. Spectral karyotyping confirmed the der(11)t(11; 12)(q23;q13) and clarified the origin of marker chromosomes, resulting in del(5q) and del(7q). Fluorescence in situ hybridization (FISH) analyses with a probe for the MLL gene demonstrated that the breakpoints at 11q23 were telomeric to the MLL gene in both cases. FISH also showed that the breakpoint at 11p15 of the case 1 was telomeric to the NUP98 gene. Considering another reported case, our results indicate that the der(11)t(11;12)(q23;q13) is a recurrent cytogenetic abnormality and may be involved in the pathogenesis of advanced-stage MDS. PMID:15527905

Yamamoto, Katsuya; Hato, Akio; Minagawa, Kentaro; Yakushijin, Kimikazu; Urahama, Norinaga; Gomyo, Hiroshi; Sada, Akiko; Okamura, Atsuo; Ito, Mitsuhiro; Matsui, Toshimitsu

2004-11-01

249

Pioneer 10/11 data analysis of the magnetic field experiment  

NASA Technical Reports Server (NTRS)

Work conducted in support of the Pioneer missions to Jupiter (10,11), and Saturn (11) as well as the reduction, analysis and interpretation of magnetic field data obtained by the vector helium magnetometer on the Pioneer 10 and 11 spacecraft is summarized. Initial efforts concentrated primarily on the interplanetary data, and those aspcts of the data of relevance to obtaining a better understanding of the interaction of the magnetized solar wind with the terrestrial magnetic field. After encounters of Jupiter and Saturn, the emphasis of research was directed primarily to an analysis of the planetary data. In particular, it soon became clear that there was a need for modelling of the various candidate magnetospheric currents suggested by the data. Results not published as yet, are also summarized.

Jones, D. E.

1982-01-01

250

Winter water; the flooding at Boise, Idaho, January 11-12, 1979  

USGS Publications Warehouse

On January 11 and 12, 1979, unseasonally warm temperatures and rain on several inches of snow lying on frozen ground caused widespread flooding in and around Boise, Idaho. Streams north of Boise crested on January 11, flooding neighborhoods in and adjacent to the mountain foothills. On January 12, streams south and west of the city reached their highest stages. Flooding was confined to ground levels and basements of homes and businesses in low-lying areas. The U.S. Geological Survey made indirect measurements of peak dicharges at selected sites on streams that had the worst flooding. The peak discharges were relatively low in comparison with data from historic floods. Much more severe flooding than this event is likely to occur in the future. More data are needed on the occurrence of flooding in Boise Valley to aid in flood-protection planning. (USGS)

Harper, Robert William; Hubbard, E. F.

1980-01-01

251

Preparation and study of bunches containing 10/sup 11/ protons in the Fermilab main ring  

SciTech Connect

A scenario for combining four adjacent bunches in the Fermilab main ring into a single bunch containing 10/sup 11/ protons is described. This is to be done using a 7th sub-harmonic rf cavity. First experimental results of the procedure are shown. 4 refs.

Griffin, J.E.; MacLachlan, J.A.; Bridges, J.F.

1981-06-01

252

Suppression of complete fusion due to breakup in the reactions B10,11+Bi209  

NASA Astrophysics Data System (ADS)

Above-barrier cross sections of fission and ?-active heavy reaction products were measured for the reactions of B10,11 with Bi209. Systematic analysis showed that the fission originates almost exclusively from complete fusion (CF). Existing measurements of above-barrier fusion products for the Si30+W186 reaction, assumed to proceed exclusively through CF, were extrapolated to the current systems using statistical model calculations. This extrapolation showed that the heavy reaction products from the B10,11+Bi209 reactions include substantial components from incomplete fusion as well as from CF. Compared with fusion calculations without breakup, the CF cross sections are suppressed by 15% for B10 and 7% for B11. A consistent and systematic variation of the suppression of CF for reactions of the weakly bound nuclei Li6,7, Be9, and B10,11 on targets of Pb208 and Bi209 is found as a function of the breakup threshold energy.

Gasques, L. R.; Hinde, D. J.; Dasgupta, M.; Mukherjee, A.; Thomas, R. G.

2009-03-01

253

Viktor Lowenfeld's Visual-Haptic Continuum in Grades 9, 10, and 11.  

ERIC Educational Resources Information Center

Sixty-nine students in grades 9, 10, and 11 were tested with three of Viktor Lowenfeld's visual-haptic tests in an attempt to ascertain whether students at these levels segregated in a fashion similar to Lowenfeld's sample. Respondents were spread over the visual-haptic continuum as Lowenfeld suggested they should be. However, a large and…

Schlenker, Richard M.

254

Selectability of Print Materials in Support of the Grades 10 and 11 Social Studies Curriculum.  

ERIC Educational Resources Information Center

This project report critiques library print materials used to support grades 10 and 11 social studies curriculum in British Columbia. The data collected are intended to provide a ready reference for school librarians when considering the particular print materials listed. Four criteria were used: readability, format and style, organization, and…

Yearwood, D. B.; Yearwood, E. I.

255

Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function.  

PubMed

The chemokine receptor CXCR3 is a G protein-coupled receptor found predominantly on T cells that is activated by three ligands as follows: CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-TAC). Previously, we have found that of the three ligands, CXCL11 is the most potent inducer of CXCR3 internalization and is the physiologic inducer of CXCR3 internalization after T cell contact with activated endothelial cells. We have therefore hypothesized that these three ligands transduce different signals to CXCR3. In light of this hypothesis, we sought to determine whether regions of CXCR3 are differentially required for CXCL9, CXCL10, and CXCL11 function. Here we identified two distinct domains that contributed to CXCR3 internalization. The carboxyl-terminal domain and beta-arrestin1 were predominantly required by CXCL9 and CXCL10, and the third intracellular loop was predominantly required by CXCL11. Chemotaxis and calcium mobilization induced by all three CXCR3 ligands were dependent on the CXCR3 carboxyl terminus and the DRY sequence in the third trans-membrane domain. Our findings demonstrate that distinct domains of CXCR3 mediate its functions and suggest that the differential requirement of these domains contributes to the complexity of the chemokine system. PMID:15150261

Colvin, Richard A; Campanella, Gabriele S V; Sun, Jieti; Luster, Andrew D

2004-07-16

256

Easy Growth Experiment on Peas Stimulates Interest in Biology for 10-11 Year Old Pupils  

ERIC Educational Resources Information Center

How do we support the enthusiasm children show for biology in school? Unfortunately, lack of exciting practical work and boring biology lessons seem to make science less popular. As a senior lecturer in plant physiology at Karlstad University I have simplified experiments intended for students at university and then tested them on 10-11 year old…

McEwen, Birgitta

2007-01-01

257

Transcript of Meeting (2nd), Held on 10-11 January 1975.  

National Technical Information Service (NTIS)

A transcript of the January 10-11, 1975 meeting is presented. Members discussed contracts for reports dealing with ethical and legal issues posed by research on the fetus. Members approved a contract for a report to identify criteria of fetal viability an...

1975-01-01

258

Social inequalities and health among children aged 10–11 in The Netherlands: Causes and consequences  

Microsoft Academic Search

Socioeconomic health differences (SEHD) are relatively small in childhood. In adolescence they almost seem to disappear and among young adults they re-emerge. This article deals with mechanisms that contribute to the emergence of health differences by studying a group of 10–11 year old children in The Netherlands (n = 908). The role of determinants of health in the relation between

Fons van der Lucht; Johan Groothoff

1995-01-01

259

Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides.  

PubMed

The t(10;11)(p13;q14-21) is a non-random translocation that occurs primarily in T cell acute lymphoblastic leukemias (T-ALL), but has also been observed in leukemias and lymphomas of diverse lineages. In U937, a cell line established from a diffuse histiocytic lymphoma, a t(10;11)(p13;q14-21) fuses AF10 to CALM. AF10 is also fused to MLL by a translocation that appears quite similar at the cytogenetic level, the t(10;11)(p12;q23). Fluorescence in situ hybridization studies have demonstrated that AF10 and CALM are also involved in other hematological malignancies containing t(10;11)(p13;q21), but no data are available concerning the molecular details of AF10-CALM fusion in primary leukemias. Using RT-PCR, we amplified multiple different isoforms of AF10-CALM and CALM-AF10 fusion cDNAs from a primary T cell ALL containing a t(10;11)(p13-14;q14-21). These cDNAs arose via alternative splicing of exons from both AF10 and CALM, which we demonstrated can also occur in the native genes. We identified at least two novel AF10 exons that can be included in wild-type and fusion cDNAs. The majority of the AF10 and AF10-CALM cDNA isoforms that we identified are predicted to encode for truncated AF10 polypeptides, raising the possibility that these might have important cellular functions in normal and malignant cells, perhaps by acting as dominant negative inhibitors of full-length AF10 or related proteins. PMID:9737689

Silliman, C C; McGavran, L; Wei, Q; Miller, L A; Li, S; Hunger, S P

1998-09-01

260

Major form of NUP98/HOXC11 fusion in adult AML with t(11;12)(p15;q13) translocation exhibits aberrant trans-regulatory activity.  

PubMed

Three adult patients with de novo acute myeloid leukemia of distinct subtypes harboring t(11;12)(p15;q13) have been investigated to characterize the genes involved in that translocation. Through molecular cytogenetics, a chromosome break was detected at the 3' part of nucleoporin 98 (NUP98) gene at 11p15. Using rapid amplification of cDNA end, we identified the partner gene at 12q13, HOXC11. Molecular analysis showed that exon 12 of NUP98 was fused in-frame to exon 2 of HOXC11 in all three cases with t(11;12)(p15;q13). Therefore, this type of fusion may represent the major form of the NUP98-HOXC11 chimera so far reported. Moreover, two out of three cases had a confirmed deletion of the 3' part of NUP98 gene and more telomeric region of 11p harboring a group of tumor-suppressor genes. Interestingly, the NUP98-HOXC11 protein when assayed in a GAL4 reporter system, showed an aberrant trans-regulatory activity as compared to the wild-type HOXC11 in both COS-7 and HL-60 cells. Therefore, NUP98-HOXC11 may contribute to the leukemogenesis by interfering with the cellular mechanism of transcriptional regulation. PMID:12970787

Gu, B-W; Wang, Q; Wang, J-M; Xue, Y-Q; Fang, J; Wong, K F; Chen, B; Shi, Z-Z; Shi, J-Y; Bai, X-T; Wu, D-H; Chen, Z; Chen, S-J

2003-09-01

261

A quest for porphyrins in lunar soil - Samples from Apollo 11, 12 and 14.  

NASA Technical Reports Server (NTRS)

Analyses for porphyrins in the lunar samples were carried out by extracting the lunar soils as received by organic solvents followed by analytical demetallation using methanesulfonic acid after which free-base porphyrins, if present, were recovered and demonstrably recomplexed with divalent cations. Samples from Apollo 11 showed the presence of fluorescent substances attributed to exhaust from the descent engine. One sample from Apollo 12 showed pigments resembling porphyrins. The Apollo 14 results were negative.

Hodgson, G. W.; Kvenvolden, K.; Peterson, E.; Ponnamperuma , C.

1972-01-01

262

The ?_{12}+?_6-?_6 and ?_{11}-?_{12} Bands of ^{12}CH_3^{13}CH_3: a Frequency Analysis Including Data from the Four Lowest Vibrational States  

NASA Astrophysics Data System (ADS)

High-resolution infrared spectra of the ?_{12}+?_6-?_6 (around 820 cm^{-1}) and ?_{11}-?_{12} (around 370 cm^{-1}) bands of ^{12}CH_3^{13}CH_3 are assigned. Frequencies from these bands together with data from the ?_{12} and ?_5 fundamentals and the torsional bands were analysed in a 4-state fit to determine the torsion mediated Coriolis and Fermi interactions. As compared to normal ethane this lower symmetry isotopologue shows more complicated vibrational couplings. The combined data set includes more than 6800 frequencies and was fitted to within experimental accuracy using a 77-parameter Hamiltonian. The first determination of molecular parameters for the ?_{11} state of ^{12}CH_3^{13}CH_3 has been made and using this Hamiltonian we have provided lower state energies and partition functions between 100 and 330 K in increment of 10 K for planetary data analysis. A comparison with a 4-state fit of similar data for ^{12}CH_3^{12}CH_3 will be made. N. Moazzen-Ahmadi, J. Norooz Oliaee, and V.-M. Horneman, JQSRT, submitted.

Moazzen-Ahmadi, N.; Oliaee, J. Norooz; Horneman, V.-M.

2013-06-01

263

Coherent Raman Spectra of the nu(1) Mode of 10BF3 and 11BF3  

SciTech Connect

High resolution (0.001cm-1) coherent anti-Stokes Raman spectroscopy (CARS) was used to directly examine the v1 symmetric stretching mode of the planar symmetric D3h molecules 10BF3 and 11BF3. Simulations of the spectra were done using v1 rovibrational parameters deduced from published infrared hot-band and difference-band studies and the close similarity to the observed CARS spectra confirms the validity of the infrared constants. No significant perturbations by Fermi resonance or Coriolis interactions with nearby states are observed, in marked contrast to the case of sulfur trioxide, a similar D3h molecule recently studied. In the harmonic approximation, the 10BF3 and 11BF3 v1 Q- branches would be identical since the isotopic substitution is at the center of mass but, interestingly, the v1 stretching frequency for 11BF3 is found to be 0.198 cm-1 higher than for the lighter 10BF3 isotopomer. This counterintuitive result is reproduced almost exactly (0.200 cm -1) by ab initio calculations (B3LYP/cc-pVTZ) that included evaluation of cubic and quartic forced constants and xij anharmonicity constants. The ab initio computations also predict to within 1% the ?B, ?C changes in the rotational constants in going from the ground state to the v1=1 vibrational level. The results illustrate nicely the complementary interplay of modern infrared, Raman, and ab initio methods in obtaining and analyzing rovibrational spectra.

Kirkpatrick, Robynne; Masiello, Tony; Weber, Alfons; Nibler, Joseph W.

2006-05-01

264

The U11-48K Protein Contacts the 5? Splice Site of U12-Type Introns and the U11-59K Protein? †  

PubMed Central

Little is currently known about proteins that make contact with the pre-mRNA in the U12-dependent spliceosome and thereby contribute to intron recognition. Using site-specific cross-linking, we detected an interaction between the U11-48K protein and U12-type 5? splice sites (5?ss). This interaction did not require branch point recognition and was sensitive to 5?ss mutations, suggesting that 48K interacts with the 5?ss during the first steps of prespliceosome assembly in a sequence-dependent manner. RNA interference-induced knockdown of 48K in HeLa cells led to reduced cell growth and the inhibition of U12-type splicing, as well as the activation of cryptic, U2-type splice sites, suggesting that 48K plays a critical role in U12-type intron recognition. 48K knockdown also led to reduced levels of U11/U12 di-snRNP, indicating that 48K contributes to the stability and/or formation of this complex. In addition to making contact with the 5?ss, 48K interacts with the U11-59K protein, a protein at the interface of the U11/U12 di-snRNP. These studies provide important insights into the protein-mediated recognition of the U12-type 5?ss, as well as functionally important interactions within the U11/U12 di-snRNP.

Turunen, Janne J.; Will, Cindy L.; Grote, Michael; Luhrmann, Reinhard; Frilander, Mikko J.

2008-01-01

265

6-Nitro-2,3-dihydro-1H-pyrrolo-[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione  

PubMed Central

In the two mol­ecules of the asymmetric unit of the title compound, C12H11N3O4, the seven-membered diazepine ring adopts a boat conformation (with the two phenyl­ene C atoms representing the stern and the methine C atom the prow). The five-membered pyrrole ring, which has an envelope conformation, makes dihedral angles of 60.47?(10) and 54.69?(9)° with the benzene ring of the benzodiazepine unit in the two mol­ecules. In the crystal, inter­molecular N—H?O hydrogen bonds and ?–? stacking inter­actions [centroid–centroid distance = 3.8023?(7)–3.8946?(7)?Å] lead to the formation of a three-dimensional framework.

Jebani, Abdessamad; Zouihri, Hafid; El Hakmaoui, Ahmed; Lazar, Said; Akssira, Mohamed

2011-01-01

266

Efficient fluorescent white organic light-emitting devices based on a ultrathin 5,6,11,12-tetraphenylnaphthacene layer  

NASA Astrophysics Data System (ADS)

White organic light-emitting devices (OLEDs) were fabricated using a ultrathin layer 5,6,11,12-tetraphenylnaphthacene as the yellow light-emitting layer and p-bis( p- N, N-diphenyl-aminostyryl)benzene (DSA-ph) doped in 2-methyl-9,10-di(2-naphthyl)anthracene (MADN) matrix as the blue light-emitting layer. The thickness of rubrene ultrathin layer will seriously affect the device performance, and the device with 1 nm rubrene achieves the best performance, with the maximum luminance of 33,152 cd/m 2 at 11 V and the maximum current efficiency of 8.69 cd/A at 7 V.

Xue, Qin; Zhang, Shiming; Xie, Guohua; Zhang, Zhensong; Zhao, Li; Luo, Yang; Chen, Ping; Zhao, Yi; Liu, Shiyong

2011-03-01

267

Expression, purification and osteogenic bioactivity of recombinant human BMP4,-9,-10,-11 and-14  

Microsoft Academic Search

Bone morphogenetic proteins (BMPs) are cytokines from the TGF-beta\\u000d\\u000a superfamily, with important roles during embryonic development and in\\u000d\\u000a the induction of bone and cartilage tissue differentiation in the adult\\u000d\\u000a body. In this contribution, we report the expression of recombinant\\u000d\\u000a human BMPA, BMP-9, BMP-10, BMP-11 (or growth differentiation factor-11,\\u000d\\u000a GDF-11) and BMP-14 (GDF-5), using Escherichia coli pET-25b vector. BMPs\\u000d\\u000a were overexpressed,

P. C. Bessa; M. T. Cerqueira; T. Rada; M. E. Gomes; N. M. Neves; A. Nobre; R. L. Reis; M. Casal

2009-01-01

268

Meteoritic material in lunar highland samples from the Apollo 11 and 12 sites  

NASA Technical Reports Server (NTRS)

Radiochemical neutron activation analyses for Ag, Au, Bi, Br, Cd, Cs, Ge, In, Ir, Ni, Os, Pd, Rb, Re, Sb, Te, Tl, U and Zn were carried out on 11 samples from the Apollo 11 and 12 sites (two samples of rock 12013, one granitic and one KREEPy; 4 KREEP fragments from 2-4 mm soil 12033,2; 4 anorthositic fragments from 1-3 mm soil 10085,104; 1 sample of 'Luny' rock-felsite-KREEP breccia 12013 10085,31 LR-1). Most Apollo 12 samples were found to have an Imbrium meteoritic component; others, typified by the Luny breccia, apparently contain a new meteoritic component of low Re content. Components of higher Ir/Au ratio (3L, 5L and 7) were found in Apollo 11 anorthositic samples; the fact that their enrichment in meteoritic siderophiles parallels that of Fe, Mg, REE and other KREEP elements is consistent with progressive contamination of an anorthositic crust. The Luny rock was tentatively classified Group 2, supporting the assignment of this group to Serenitatis.

Janssens, M.-J.; Hertogen, J.; Palme, H.; Anderson, A. T.; Anders, E.

1978-01-01

269

Stratospheric loss and atmospheric lifetimes of CFC-11 and CFC-12 derived from satellite observations  

NASA Astrophysics Data System (ADS)

The lifetimes of CFC-11 and CFC-12 have been evaluated using global observations of their stratospheric distributions from satellite-based instruments over the time period from 1992 to 2010. The chlorofluorocarbon (CFC) datasets are from the Cryogen Limb Array Etalon Spectrometer (CLAES), the Cryogenic Infrared Spectrometers and Telescopes for the Atmosphere (CRISTA-1 and CRISTA-2), the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS), and the Atmospheric Chemistry Experiment (ACE). Stratospheric loss rates were calculated using an ultraviolet radiative transfer code with updated cross section and solar irradiance data. Mean steady-state lifetimes based on these observations are 44.7 (36-58) yr for CFC-11 and 106.6 (90-130) yr for CFC-12, which are in good agreement with the most recent WMO ozone assessment. There are two major sources of error in calculating lifetimes using this method. The first important error arises from uncertainties in tropical stratospheric observations, particularly for CFC-11. Another large contribution to the error is due to uncertainties in the penetration of solar ultraviolet radiation at wavelengths between 185 and 220 nm, primarily in the tropical stratosphere between 20 and 35 km altitude.

Minschwaner, K.; Hoffmann, L.; Brown, A.; Riese, M.; Müller, R.; Bernath, P. F.

2013-04-01

270

t-10, c-12 CLA Dietary Supplementation Inhibits Atherosclerotic Lesion Development Despite Adverse Cardiovascular and Hepatic Metabolic Marker Profiles  

PubMed Central

Animal and human studies have indicated that fatty acids such as the conjugated linoleic acids (CLA) found in milk could potentially alter the risk of developing metabolic disorders including diabetes and cardiovascular disease (CVD). Using susceptible rodent models (apoE?/? and LDLr?/? mice) we investigated the interrelationship between mouse strain, dietary conjugated linoleic acids and metabolic markers of CVD. Despite an adverse metabolic risk profile, atherosclerosis (measured directly by lesion area), was significantly reduced with t-10, c-12 CLA and mixed isomer CLA (Mix) supplementation in both apoE?/? (p<0.05, n?=?11) and LDLr?/? mice (p<0.01, n?=?10). Principal component analysis was utilized to delineate the influence of multiple plasma and tissue metabolites on the development of atherosclerosis. Group clustering by dietary supplementation was evident, with the t-10, c-12 CLA supplemented animals having distinct patterns, suggestive of hepatic insulin resistance, regardless of mouse strain. The effect of CLA supplementation on hepatic lipid and fatty acid composition was explored in the LDLr?/? strain. Dietary supplementation with t-10, c-12 CLA significantly increased liver weight (p<0.05, n?=?10), triglyceride (p<0.01, n?=?10) and cholesterol ester content (p<0.01, n?=?10). Furthermore, t-10, c-12 CLA also increased the ratio of 18?1 to 18?0 fatty acid in the liver suggesting an increase in the activity of stearoyl-CoA desaturase. Changes in plasma adiponectin and liver weight with t-10, c-12 CLA supplementation were evident within 3 weeks of initiation of the diet. These observations provide evidence that the individual CLA isomers have divergent mechanisms of action and that t-10, c-12 CLA rapidly changes plasma and liver markers of metabolic syndrome, despite evidence of reduction in atherosclerosis.

Mitchell, Patricia L.; Karakach, Tobias K.; Currie, Deborah L.; McLeod, Roger S.

2012-01-01

271

The 1H(11B,n)11C reaction as a practical low background monoenergetic neutron source in the 10 MeV region  

Microsoft Academic Search

Neutron source properties of the 1H(11B,n)11C reaction were measured for incident 11B energies between 50 and 64 MeV by detecting the neutrons at angles of 0° to 40°. Neutron were produced with high monochromaticity in the range of several MeV to 12 MeV. In addition, the room background is very low because they were collimated to a forward cone according

Satoshi Chiba; Motoharu Mizumoto; Kazuo Hasegawa; Yoshimaro Yamanouti; Masayoshi Sugimoto; Yukinobu Watanabe; Manfred Drosg

1989-01-01

272

Saturated Liquid Densities of HCFC123, HFC134a, CFC11 and CFC12  

NASA Astrophysics Data System (ADS)

The saturated liquid densities of two environmentally acceptable hydrogen-containing halocarbons (HCFC123 and HFC134a) and two fully halogenated chlorofluorocarbons (CFCl1 and CFC12) were determined experimentally. The measurement has been conducted by the method using pyrex glass floats. Eleven saturated liquid densities were obtained in the range of temperature from 281 to 352 K for HCFC123. Seven saturated liquid densities were obtained in the range of temperature from 244 to 292 K for HFC134a. Eleven saturated liquid densities were obtained in the range of temperature from 285 to 361 K for CFC11. And ten saturated liquid densities were obtained in the range of temperature from 237 to 297 K for CFC12. The uncertainties of temperature and density are less than ±20 mK and ±3 kg/m3, respectively. On the basis of these results, the saturated liquid density correlations were developed for four halocarbons. The satuated liquid densities for HCFC123 are close to those for CFC11. And the saturated liquid densities for HFC134a are smaller than those for CFC12.

Fukushima, Masato

273

12 CFR 1301.10 - Requests for business information provided to the Council.  

Code of Federal Regulations, 2013 CFR

12 Banks and Banking 9 2013-01-01 2013-01-01...10 Section 1301.10 Banks and Banking FINANCIAL STABILITY OVERSIGHT COUNCIL FREEDOM...trade secrets or other commercial or financial information that may be...

2013-01-01

274

Cosmic ray radial intensity gradients measured by Pioneer 10 and Pioneer 11  

NASA Technical Reports Server (NTRS)

The paper reports revised and updated measurements of the cosmic ray radial intensity gradient made with Pioneer 10 and 11 over the radial range 1-5 AU in differential energy windows from 10-70 MeV/nucleon, and for the integral intensity exceeding 70 MeV/nucleon. In most cases small positive gradients are found of the order of a few percent per AU, with evidence for significant temporal variations. Spectral studies show the presence of the 'anomalous' helium component below 50 MeV at all radial distances from 1-5 AU.

Mckibben, R. B.; Pyle, K. R.; Simpson, J. A.; Tuzzolino, A. J.; Ogallagher, J. J.

1975-01-01

275

Quantitative and Qualitative Microbiological Profiles of the Apollo 10 and 11 Spacecraft  

PubMed Central

Microbiological profiles were determined for surfaces of the command module, lunar module (ascent and descent stages), instrument unit, Saturn S-4B stage, and the spacecraft lunar module adapter of the Apollo 10 and 11 spacecraft. Average levels of contamination of the command module were 2.1 × 104 and 2.7 × 104 microorganisms per ft2 for Apollo 10 and 11, respectively. With the exception of the exterior surfaces of the ascent stage of the lunar module and the interior surfaces of the command module, average levels of microbial contamination on all components of the Apollo 11 were found to be lower than those observed on Apollo 10. For each Apollo mission, approximately 2,000 colonies were picked from a variety of media and identified. The results showed that approximately 95% of all isolates were those considered indigenous to humans; the remaining were associated with soil and dust in the environment. However, the ratio of these two general groups varied depending on the degrees of personnel density and environmental control associated with each module.

Puleo, John R.; Oxborrow, Gordon S.; Fields, Norman D.; Hall, Herbert E.

1970-01-01

276

The apparent anomalous, weak, long-range acceleration of Pioneer 10 and 11  

SciTech Connect

Recently the authors reported that radio Doppler data generated by NASA`s Deep Space Network (DSN) with the Pioneer 10 and 11 spacecraft indicate an apparent anomalous, constant, spacecraft acceleration with a magnitude {approximately}8.5 {times} 10{sup {minus}8} cm s{sup {minus}2}, directed towards the Sun. Analysis of similar Doppler and ranging data from the Galileo and Ulysses spacecraft yielded ambiguous results for the anomalous acceleration, but the analysis was useful in that it ruled out the possibility of a systematic error in the DSN Doppler system that could easily be mistaken as a spacecraft acceleration. Here they present some new results, including a critique of the suggestion that the anomalous acceleration could be caused by collimated thermal emission. Based on upgraded JPL software for the Pioneer 10 orbit determination, and on a new data interval from January 1987 to July 1998, their best estimate of the average Pioneer 10 acceleration directed towards the Sun is 7.20 {sup {minus}} 0.11 {times} 10{sup {minus}8} cm s{sup {minus}2}.

Anderson, J.D.; Lau, E.L.; Turyshev, S.G. [California Inst. of Tech., Pasadena, CA (United States). Jet Propulsion Lab.; Laing, P.A. [Aerospace Corp., El Segundo, CA (United States); Liu, A.S. [Astrodynamic Sciences, Los Angeles, CA (United States); Nieto, M.M. [Los Alamos National Lab., NM (United States). Theoretical Div.

1999-07-01

277

Spectral Anomalies in the 11 and 12 micron Region From the Mariner Mars 7 Infrared Spectrometer  

NASA Technical Reports Server (NTRS)

Two hundred-forty infrared spectra acquired by the 1969 Mariner Mars 7 Infrared Spectrometer (IRS), spanning the wavelength region 1.8-14.4 micron (5550-690/cm), have recently been recovered and calibrated in both wavelength and intensity. An examination of these IRS spectra has revealed absorptions at 11.25 and 12.5 micron that have not previously been reported for Mars. A search of the literature and spectral data bases shows that materials that exhibit a doublet at 11.25 and 12.5 micron are rare. In this paper we examine potential causes for these features and include a detailed discussion of carbonates, goethite, CO2 ice, and water ice. CO2 ice and water ice measured in transmission do not exhibit bands that match those recorded at 11.25 and 12.5 micron for Mars, which indicates that CO2 or water ice clouds are not the source of these features. Since these bands show no clear correlation with atmospheric path length, they are most likely caused by a surface material. In the IRS database they appear to be exceptionally intense in the western part of the Hellas basin. Goethite exhibits bands that are a good spectral match, but confirming whether goethite causes the features will require additional studies of the 20-50 micron region. These studies will require laboratory measurements of weathering coatings and an examination of spectra recorded of Mars by the 1971 Mariner Mars Infrared Interferometer Spectrometer (IRIS; 5-50 micron 2000200/cm) and the 1996 Thermal Emission Spectrometer (TES; 6-50 micron 1667-200/cm).

Kirkland, Laurel E.; Herr, Kenneth C.

2000-01-01

278

49 CFR 174.105 - Routing shipments, Division 1.1 or 1.2 (explosive) materials.  

Code of Federal Regulations, 2013 CFR

...shipments, Division 1.1 or 1.2 (explosive) materials. 174.105 Section...REGULATIONS CARRIAGE BY RAIL Class I (Explosive) Materials § 174.105 Routing...shipments, Division 1.1 or 1.2 (explosive) materials. Before a...

2013-10-01

279

49 CFR 176.100 - Permit for Divisions 1.1 and 1.2 (explosive) materials.  

Code of Federal Regulations, 2013 CFR

...Permit for Divisions 1.1 and 1.2 (explosive) materials. 176.100 Section...Detailed Requirements for Class 1 (Explosive) Materials § 176.100 Permit for Divisions 1.1 and 1.2 (explosive) materials. Before Divisions...

2013-10-01

280

49 CFR 174.104 - Division 1.1 or 1.2 (explosive) materials; car selection, preparation, inspection, and...  

Code of Federal Regulations, 2013 CFR

...Division 1.1 or 1.2 (explosive) materials; car selection, preparation, inspection, and...1.1 or 1.2 (explosive) materials; car selection, preparation, inspection, and...certified and properly placarded closed car of not less than 36,300 kg...

2013-10-01

281

Nomen est Omen: do antidepressants increase p11 or S100A10?  

PubMed Central

Occasionally, multiple names are given to the same gene/protein. When this happens, different names can be used in subsequent publications, for example in different research areas, sometimes with little or no awareness that the same entity known under a different name may have a major role in another field of science. Recent reports about the protein p11 presented findings that this protein, commonly known as S100A10, may play a crucial role in depression and antidepressant treatment mechanisms. One set of data showed an increased expression of this protein in the brain of mice treated with antidepressants. P11/S100A10 is only one of several S100 proteins expressed in the brain. Interestingly, it has been previously noted that antidepressant treatment increases the brain content of another S100 protein, S100B. It appears that up-regulating the brain content of various S100 proteins might be a common feature of antidepressants. In cells coexpressing S100A10 and S100B, these proteins may interact and exert opposite regulatory roles. Nevertheless, S100A10 is predominantly expressed in certain types of neurons whereas S100B is more abundant in glia. Thus, an interplay among multiple members of the S100 proteins might be important in determining the region and cell specificity of antidepressant mechanisms. Calling the p11 protein by its other name, S100A10, may prompt more investigators from different fields to participate in this new direction of neurobiological research.

Manev, Hari; Manev, Radmila

2006-01-01

282

Nuclear charge radii of 7,9,10Be and the one-neutron halo nucleus 11Be.  

PubMed

Nuclear charge radii of ;{7,9,10,11}Be have been determined by high-precision laser spectroscopy. On-line measurements were performed with collinear laser spectroscopy in the 2s_{1/2}-->2p_{1/2} transition on a beam of Be+ ions. Collinear and anticollinear laser beams were used simultaneously, and the absolute frequency determination using a frequency comb yielded an accuracy in the isotope-shift measurements of about 1 MHz. Combining this with accurate calculations of the mass-dependent isotope shifts yields nuclear charge radii. The charge radius decreases from 7Be to 10Be and then increases for the halo nucleus 11Be. When comparing our results with predictions of ab initio nuclear-structure calculations we find good agreement. Additionally, the nuclear magnetic moment of 7Be was determined to be -1.3995(5)micro_{N} and that of 11Be was confirmed with an accuracy similar to previous beta-NMR measurements. PMID:19257582

Nörtershäuser, W; Tiedemann, D; Záková, M; Andjelkovic, Z; Blaum, K; Bissell, M L; Cazan, R; Drake, G W F; Geppert, Ch; Kowalska, M; Krämer, J; Krieger, A; Neugart, R; Sánchez, R; Schmidt-Kaler, F; Yan, Z-C; Yordanov, D T; Zimmermann, C

2009-02-13

283

CARD11 blockade suppresses murine collagen-induced arthritis via inhibiting CARD11/Bcl10 assembly and T helper type 17 response.  

PubMed

The scaffold protein caspase recruitment domain-containing protein 11 (CARD11) is implicated in the regulation of inflammation and autoimmunity. The present study aimed to explore the role of CARD11 in the pathogenesis of rheumatoid arthritis (RA). Mice with collagen-induced arthritis (CIA) were treated with either CARD11-targeted interfering RNA (CARD11 siRNA) or control siRNA by intraperitoneal injection every 3 days after CIA establishment. The clinical score of arthritis was recorded every other day. Synovial inflammation and cartilage erosion were evaluated by histology and microcomputed tomography (micro-CT). Serum anti-type II collagen (anti-CII) antibodies and cytokines were measured by enzyme-linked immunosorbent assay (ELISA). The CARD11/Bcl10 formation and nuclear factor-kappa B (NF-?B) activation was assessed by immunoprecipitation and immunoblotting, and the percentage of T helper type 17 (Th17) cells was determined by flow cytometry. Systemic administration of CARD11 siRNA significantly reduced the clinical score of CIA severity. As indicated by the histology, joint inflammation and destruction were attenuated by CARD11 siRNA treatment. Micro-CT demonstrated less severe joint destruction in CARD11 siRNA-treated mice than in control mice. CARD11 siRNA treatment resulted in inhibition of CARD11/Bcl10 formation and the subsequent NF-?B activation. In addition, treatment with CARD11 siRNA resulted in a pronounced decrease in proinflammatory cytokines interleukin (IL)-1?, IL-6 and IL-17. Serum anti-CII antibody and the percentage of Th17 cells were also significantly reduced. CARD11 is involved in the pathogenesis of CIA by formation of the CARD11/Bcl10 complex and enhancement of the Th17 cell response. Targeting CARD11 provides a novel research direction in the development of therapeutic strategies for RA. PMID:24443940

Wang, H; Zhao, J; Zhang, H; Huang, Y; Wang, S; Tu, Q; Yang, N

2014-05-01

284

(13) CO(1-0) and (12) CO(2-1) in the center of the barred galaxy NGC 1530  

NASA Astrophysics Data System (ADS)

We present (13) CO(1-0) and (12) CO(2-1) aperture synthesis maps of the barred spiral galaxy {NGC 1530}. The angular resolutions are respectively 3''.1 and 1''.6. Both transitions show features similar to the (12) CO(1-0) map, with a nuclear feature (a ring or unresolved spiral arms) surrounded by two curved arcs. The average line ratios are (12) CO(1-0)/(13) CO(1-0)=9.3 and (12) CO(2-1)/(12) CO(1-0)=0.7. The (12) CO/(13) CO ratio is lower in the circumnuclear ring (6-8) than in the arcs (11-15). We fit the observed line ratios by escape probability models, and deduce that the gas density is probably higher in the nuclear feature (>= 5E2 cm(-3) ) than in the arcs ( =~ 2E2 cm(-3) ), confirming earlier HCN results. The kinetic temperatures are in the range 20-90 K, but are weakly constrained by the model. The average filling factor of the (12) CO(1-0) emitting gas is low, =~ 0.15. The cm-radio continuum emission also peaks in the nuclear feature, indicating a higher rate of star formation than in the arcs. We derive values for the CO luminosity to molecular gas mass conversion factor between 0.3 and 2.3 mo (K km s(-1) pc(2) )(-1), significantly lower than the standard Galactic value.

Reynaud, D.; Downes, D.

1999-07-01

285

Reactions of ( E)-1,2-di(3-guaiazulenyl)ethylene and 2-(3-guaiazulenyl)-1,1-bis(4-methoxyphenyl)ethylene with tetracyanoethylene (TCNE) in benzene: comparative studies on the products and their spectroscopic properties  

Microsoft Academic Search

Reactions of the title ethylene derivatives, (E)-1,2-di(3-guaiazulenyl)ethylene (1) and 2-(3-guaiazulenyl)-1,1-bis(4-methoxyphenyl)ethylene (2), with a 2M amount of TCNE in benzene at 25°C for 24h under argon give new cycloaddition compounds, 1,1,2,2,11,11,12,12-octacyano-3-(3-guaiazulenyl)-8-isopropyl-5,10-dimethyl-1,2,3,6,9,10a-hexahydro-6,9-ethanobenz[a]azulene (3) from 1 and 1,1,2,2,11,11,12,12-octacyano-8-isopropyl-3,3-bis(4-methoxyphenyl)-5,10-dimethyl-1,2,3,6,9,10a-hexahydro-6,9-ethanobenz[a]-azulene (4) from 2, respectively, in 66 and 87% isolated yields. Comparative studies on the above reactions as well as the spectroscopic properties of the unique

Shin-ichi Takekuma; Masanori Hirosawa; Seiko Morishita; Masato Sasaki; Toshie Minematsu; Hideko Takekuma

2006-01-01

286

19 CFR 12.10 - Regulations and orders of the Department of Agriculture.  

Code of Federal Regulations, 2010 CFR

...Regulations and orders of the Department of Agriculture. 12.10 Section 12.10 Customs...Regulations and orders of the Department of Agriculture. The importation into the United...regulations and orders of the Department of Agriculture restricting or prohibiting the...

2010-04-01

287

19 CFR 12.10 - Regulations and orders of the Department of Agriculture.  

Code of Federal Regulations, 2012 CFR

...Regulations and orders of the Department of Agriculture. 12.10 Section 12.10 Customs...Regulations and orders of the Department of Agriculture. The importation into the United...regulations and orders of the Department of Agriculture restricting or prohibiting the...

2012-04-01

288

19 CFR 12.10 - Regulations and orders of the Department of Agriculture.  

...Regulations and orders of the Department of Agriculture. 12.10 Section 12.10 Customs...Regulations and orders of the Department of Agriculture. The importation into the United...regulations and orders of the Department of Agriculture restricting or prohibiting the...

2014-04-01

289

19 CFR 12.10 - Regulations and orders of the Department of Agriculture.  

Code of Federal Regulations, 2011 CFR

...Regulations and orders of the Department of Agriculture. 12.10 Section 12.10 Customs...Regulations and orders of the Department of Agriculture. The importation into the United...regulations and orders of the Department of Agriculture restricting or prohibiting the...

2011-04-01

290

CXCR7 Functions as a Scavenger for CXCL12 and CXCL11  

PubMed Central

Background CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses. The function of CXCR7 is controversial. Some studies suggest a signaling activity in mammalian cells and zebrafish embryos, while others indicate a decoy activity in fish. Here we investigated the two propositions in human tissues. Methodology/Principal Findings We provide evidence and mechanistic insight that CXCR7 acts as specific scavenger for CXCL12 and CXCL11 mediating effective ligand internalization and targeting of the chemokine cargo for degradation. Consistently, CXCR7 continuously cycles between the plasma membrane and intracellular compartments in the absence and presence of ligand, both in mammalian cells and in zebrafish. In accordance with the proposed activity as a scavenger receptor CXCR7-dependent chemokine degradation does not become saturated with increasing ligand concentrations. Active CXCL12 sequestration by CXCR7 is demonstrated in adult mouse heart valves and human umbilical vein endothelium. Conclusions/Significance The finding that CXCR7 specifically scavenges CXCL12 suggests a critical function of the receptor in modulating the activity of the ubiquitously expressed CXCR4 in development and tumor formation. Scavenger activity of CXCR7 might also be important for the fine tuning of the mobility of hematopoietic cells in the bone marrow and lymphoid organs.

Naumann, Ulrike; Cameroni, Elisabetta; Pruenster, Monika; Mahabaleshwar, Harsha; Raz, Erez; Zerwes, Hans-Gunter; Rot, Antal; Thelen, Marcus

2010-01-01

291

Preparation and crystal structure of the carbide Gd 10.34Mn 12.66C 18  

Microsoft Academic Search

The new carbide Gd10.34Mn12.66C18 has been prepared by arc-melting cold-pressed pellets of the elemental components and subsequent annealing at 900 °C. Well developed crystals were obtained using a lithium flux. Their Th11Ru12C18-type crystal structure was determined from single-crystal X-ray data: I43m, Z = 2, a = 1026.9(1) pm, R = 0.015 for 502 structure factors and 15 variable parameters. One

Udo A Böcker; Wolfgang Jeitschko

1996-01-01

292

Pioneer 10 and 11 (Jupiter and Saturn) magnetic field experiments. Final report  

SciTech Connect

Magnet field data obtained by the vector helium magnetometer (VHM) during the encounters of Jupiter (Pioneer 10 and 11) and Saturn (Pioneer 11) was analyzed and interpreted. The puzzling characteristics of the Jovian and Saturnian magnetospheric magnetic fields were studied. An apparent substorm (including thinning of the dayside tail current sheet) was observed at Jupiter, as well as evidence suggesting that at the magnetopause the cusp is at an abnormally low latitude. The characteristics of Saturn's ring current as observed by Pioneer 11 were dramatically different from those suggested by the Voyager observations. Most importantly, very strong perturbations in the azimuthal ring current magnetic field suggest that the plane of the ring was not in the dipole equatorial plane, being tilted 5 to 10 deg. relative to the dipole and undergoing significant changes during the encounter. When these changing currents were corrected for, an improved planetary field determination was obtained. In addition, the ring and azimuthal currents at Saturn displayed significantly different time dependences.

Jones, D.E.

1986-10-01

293

Solution and solid-state structure of the anion [Ag(2)[closo-CB(11)H(12)](4)](2-).  

PubMed

Addition of the carbene 1,3-dimesitylimidazol-2-ylidene (IMes) to a toluene solution of Ag[closo-CB(11)H(12)] results in the formation of the complex [(IMes)(2)Ag](2)[Ag(2)[closo-CB(11)H(12)](4)], the anionic component of which contains two silver(I) centers bridged by two carboranes in addition to one terminally bound carborane on each metal, in the solid-state. Comparison of the observed (11)B[(1)H] NMR chemical shifts of [(IMes)(2)Ag](2)[Ag(2)[closo-CB(11)H(12)](4)] or Ag[closo-CB(11)H(12)] with [NBu(4)][closo-CB(11)H(12)] in CD(2)Cl(2) demonstrates that the silver ion interacts significantly with the cage in solution. Theoretical investigations using the ab initio/GIAO/NMR method of [closo-CB(11)H(12)](-) and Na[closo-CB(11)H(12)] as model geometries for the silver salts support experimental evidence for these Ag...[BH] interactions in solution. PMID:12184776

Fox, Mark A; Mahon, Mary F; Patmore, Nathan J; Weller, Andrew S

2002-08-26

294

Tropospheric chlorine isotope measurements in CFC-11, CFC-12 and CFC-113  

NASA Astrophysics Data System (ADS)

In 2010, we reported the first measurements of chlorine isotope fractionation in stratospheric dichlorodifluoromethane (CF2Cl2, CFC-12) (Laube et al., Science 329:1167, 2010). We found an increase in the isotope delta, ?(37Cl), with altitude and a tight correlation between ln[1 + ?(37Cl)] and ln(mixing ratio). The derived apparent isotope fractionation was ?app = (-12 ± 2) o. The stratospheric isotopic fractionation should lead to a continuous increase of the tropospheric chlorine isotope delta while CFC-12 is still emitted into the atmosphere. Provided the source signature has not changed, we predict a 2.5 to 3 o increase since when CFC emissions started in the 1930s until 2010, with the strongest increase in recent years (about 1 o per decade since the mid-1990s). We have now measured the chlorine isotope delta of CFC-12 as well as CFC-11 (trichlorofluoromethane, CFCl3) and CFC-113 (1,1,2-trichloro-1,2,2-trifluoroethane, C2F3Cl3) in the Cape Grim Air Archive (1978 to 2010) and Arctic (NEEM, Greenland) and Antarctic firn samples (Fletcher, West Antarctica). The deepest firn samples include a significant proportion of older air from before 1978. The repeatability for individual samples was ±2.6o for CFC-12 and ±2.7o for CFC-11 and ±3.7o for CFC-113. The results show no significant trends in ?(37Cl) over the whole time period; however, there is a small positive trend for the latter period of the samples of (0.3 ± 0.1) o per decade for CFC-12 since 1997, which explains at third of the predicted trend. The discrepancy between observed and predicted trends may be due to offsetting changes in the source isotope signature: If the there was decrease in the isotope delta of the emissions over time, this would reduce the predicted increase caused by downward transport of 37Cl-enriched stratospheric air.

Allin, Sam; Kaiser, Jan; Laube, Johannes; Sturges, Bill

2014-05-01

295

The radial intensity gradients for cosmic rays and the anomalous helium from Pioneer 10 and 11  

NASA Astrophysics Data System (ADS)

This report extends and updates previous studies of the heliocentric radial gradients of the integral flux of cosmic rays (E greater than 70 MeV) and of differential fluxes of protons and helium nuclei in the approximate energy windows 11-20 and 30-70 MeV/n to include data taken through the end of 1978 when Pioneer 10 had reached a distance of 18 AU from the sun, and Pioneer 11 was at a distance of 8.4 AU. Small positive gradients are found for all species considered, although the actual values of the gradients may vary as a function of time. The data suggest that the modulation region has a radial extent large compared to 18 AU. The anomalous helium component was observed at all radial distances, and is found to have a much higher flux in the outer solar system than near 1 AU.

Bastian, T. S.; McKibben, R. B.; Pyle, K. R.; Simpson, J. A.

1980-10-01

296

The radial intensity gradients for cosmic rays and the anomalous helium from Pioneer 10 and 11  

NASA Technical Reports Server (NTRS)

This report extends and updates previous studies of the heliocentric radial gradients of the integral flux of cosmic rays (E greater than 70 MeV) and of differential fluxes of protons and helium nuclei in the approximate energy windows 11-20 and 30-70 MeV/n to include data taken through the end of 1978 when Pioneer 10 had reached a distance of 18 AU from the sun, and Pioneer 11 was at a distance of 8.4 AU. Small positive gradients are found for all species considered, although the actual values of the gradients may vary as a function of time. The data suggest that the modulation region has a radial extent large compared to 18 AU. The anomalous helium component was observed at all radial distances, and is found to have a much higher flux in the outer solar system than near 1 AU.

Bastian, T. S.; Mckibben, R. B.; Pyle, K. R.; Simpson, J. A.

1980-01-01

297

Non-Structured Amino-Acid Impact on GH11 Differs from GH10 Xylanase  

PubMed Central

The Aspergillus niger xylanase (Xyn) was used as a model to investigate impacts of un-structured residues on GH11 family enzyme, because the ?-jelly roll structure has five residues (Ser1Ala2Gly3Ile4Asn5) at N-terminus and two residues (Ser183Ser184) at C-terminus that do not form to helix or strand. The N- or/and C-terminal residues were respectively deleted to construct three mutants. The optimal temperatures of Xyn?N, Xyn?C, and Xyn?NC were 46, 50, and 46°C, and the thermostabilities were 15.7, 73.9, 15.5 min at 50°C, respectively, compared to 48°C and 33.9 min for the Xyn. After kinetic analysis, the substrate-binding affinities for birch-wood xylan decreased in the order Xyn?C>Xyn>Xyn?NC>Xyn?N, while the Kcat values increased in the order Xyn?C11 xylanase thermostability and Topt, while the N- and NC-terminal deletions decreased its thermostability and optimal temperature. The C-terminal residues created more impact on enzyme thermal property, while the N-terminal residues created more impact on its catalytic efficiency and substrate-binding affinity. The impact of non-structured residues on GH11 xylanase was different from that of similar residues on GH10 xylanase, and the difference is attributed to structural difference between GH11 jelly-roll and GH10 (?/?)8.

Liu, Liangwei; Sun, Xiaofeng; Yan, Pengfei; Wang, Linmin; Chen, Hongge

2012-01-01

298

Synthesis of 4,4,8,8,11,11-Hexanitropentacyclo(5.4.0.0(2,6).0(3,10).0(5,9)-undecane,  

National Technical Information Service (NTIS)

The synthesis of the title compound (1) has been accomplished in seven steps by starting with the readily available 4,4,11,11-bis(ethylenedioxy)pentacyclo(5.4.0.02,6.03,10.05,9)-undecane- 9-one (2). Thus, 2 was converted into the corresponding oxime, 3 (7...

A. P. Marchand B. E. Arney D. Rajapaksa J. L. Flippen-Anderson P. R. Dave

1989-01-01

299

Slot-coupled T-junction of TE(11) coaxial to TE(10) rectangular waveguide  

NASA Astrophysics Data System (ADS)

A solution is presented to the problem of a slot-coupled T-junction of a TE(11)-mode coaxial to a TE(10)-mode rectangular waveguide. A variational technique is employed which combines the reaction concept with the field representation of a waveguide slot and leads to a closed-form solution for the junction scattering matrix. Numerical examples illustrate the characteristics of such a junction in practical applications. Good agreement between theory and experiment is obtained. Design criteria and examples are presented and discussed.

Saad, S. M.

1986-01-01

300

A new ultrafast superionic Li-conductor: ion dynamics in Li11Si2PS12 and comparison with other tetragonal LGPS-type electrolytes.  

PubMed

We report on a new ultrafast solid electrolyte of the composition Li11Si2PS12, which exhibits a higher room-temperature Li ion diffusivity than the present record holder Li10GeP2S12. We discuss the high-pressure synthesis and ion dynamics of tetragonal Li11Si2PS12, and comparison is made with our investigations of related members of the LMePS family, i.e. electrolytes of the general formula Li11-xMe2-xP1+xS12 with Me = Ge, Sn?:?Li10GeP2S12, Li7GePS8, Li10SnP2S12. The structure and dynamics were studied with multiple complementary techniques and the macroscopic diffusion could be traced back to fast Li ion hopping in the crystalline lattice. A clear correlation between the diffusivity and the unit cell volume of the LGPS-type electrolytes was observed. PMID:24916653

Kuhn, Alexander; Gerbig, Oliver; Zhu, Changbao; Falkenberg, Frank; Maier, Joachim; Lotsch, Bettina V

2014-06-25

301

Photogrammetry of the Particle Trajectories on Dipole West Shots 8, 9, 10, and 11. Volume IV. Shot 11.  

National Technical Information Service (NTIS)

This volume describes the photogrammetry and analysis of the particle trajectories in blast waves produced by the simultaneous detonation of two spherical 1080-lb (490-kg) Pentolite charges (DIPOLE WEST Shot 11). One of the charges was positioned at a hei...

J. M. Dewey D. J. McMillin D. Trill

1978-01-01

302

Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13).  

PubMed

The NUP98 gene at 11p15 is known to be fused to DDX10, HOXA9, HOXA11, HOXA13, HOXD11, HOXD13, LEDGF, NSD1, NSD3, PMX1, RAP1GDS1, and TOP1 in various hematologic malignancies. The common theme in all NUP98 chimeras is a transcript consisting of the 5' part of NUP98 and the 3' portion of the partner gene; however, apart from the frequent fusion to different homeobox genes, there is no apparent similarity among the other partners. We here report a de novo acute myeloid leukemia with a t(11;12)(p15;q13), resulting in a novel NUP98/HOXC13 fusion. Fluorescence in situ hybridization analyses, by the use of probes covering NUP98 and the HOXC gene cluster at 12q13, revealed a fusion signal at the der(11)t(11;12), indicating a NUP98/HOXC chimera, whereas no fusion was found on the der(12)t(11;12), suggesting that the translocation was accompanied by a deletion of the reciprocal fusion gene. Reverse transcription-PCR and sequence analyses showed that exon 16 (nucleotide 2290) of NUP98 was fused in-frame with exon 2 (nucleotide 852) of HOXC13. Neither the HOXC13/NUP98 transcript nor the normal HOXC13 was expressed. The present results, together with previous studies of NUP98/homeobox gene fusions, strongly indicate that NUP98/HOXC13 is of pathogenetic importance in t(11;12)-positive acute myeloid leukemia. PMID:12461755

Panagopoulos, Ioannis; Isaksson, Margareth; Billström, Rolf; Strömbeck, Bodil; Mitelman, Felix; Johansson, Bertil

2003-01-01

303

Complexation with diol host compounds. Part 1. Structures of the 1:2 molecular complexes of trans -9, 10-dihydroxy-9,10-diphenyl-9,10-dihydroanthracene with acetophenone and with 3-methylcyclopentanone  

Microsoft Academic Search

The structures of the 1:2 molecular complexes of trans -9,10-dihydroxy-9,10-diphenyl-9,10-dihydroanthracene with acetophenone (1), (C26H20O2·2 C8H8O) and with 3-methylcyclopentanone (2), (C26H20O2·2C6H10O) have been determined by X-ray crystallography. The crystal data are as follows: Compound (1):P\\u000a$$\\\\bar 1$$\\u000a,a =8.979(5) Å,b =9.316(3) Å,c = 11.12(1) Å,a =94.40(6)°,ß = 106.53(6)°,? = 109.92(5)°,V = 822.94 Å3,Z = 1,R = 0.097 for 2549 unique reflections.

Dianne R. Bond; Luigi R. Nassimbeni; Fumio Toda

1989-01-01

304

Supramolecular self-assembled aggregates formed by pentacosa-10,12-diynyl amidomethyl-?-cyclodextrin.  

PubMed

Mono[6-deoxy-6-(pentacosa-10,12-diynyl amidomethyl)]-?-cyclodextrin was successfully synthesized by reacting mono-6-amino-6-deoxy-?-cyclodextrin with N-hydroxysuccinimide ester of 10,12-pentacosadiynoic acid in DMF. The modified ?-cyclodextrin self-assembled and aggregated to form a worm-like supramolecular structure, and the novel supramolecular aggregates were studied using 2D nuclear magnetic resonance spectroscopy, X-ray powder diffraction, thermogravimetry, and electron microscopy. Interestingly, the synthesized pentacosa-10,12-diynyl amidomethyl-?-cyclodextrin formed columnar type self-aggregates and it was clearly differentiated from cage-like structure of native ?-cyclodextrin. PMID:24785385

Cho, Eunae; Kim, Hwanhee; Yang, Jee Eun; Jun, Bong-Hyun; Paik, Seung R; Jung, Seunho

2014-06-01

305

Analysis of 3-year observations of CFC-11, CFC-12 and CFC-113 from a semi-rural site in China  

NASA Astrophysics Data System (ADS)

In-situ measurements of atmospheric chlorofluorocarbons (CFCs) can be used to the assess their global and regional emissions and to check for compliance with phase-out schedules under Montreal protocol and its amendments. The atmospheric mixing ratios of CFC-11 (CCl 3F), CFC-12 (CCl 2F 2) and CFC-113 (CCl 2F-CClF 2) have been measured by an automated in-situ GC-ECDs system at the regional Chinese Global Atmosphere Watch (GAW) station Shangdianzi (SDZ), from November 2006 to October 2009. The time series for these three principal CFCs showed large episodic events and background conditions occurred for approximately 30% (CFC-11), 52% (CFC-12) and 56% (CFC-113) of the measurements. The mean background mixing ratios for CFC-11, CFC-12 and CFC-113 were 244.8 ppt (parts per trillion, 10 -12, molar) 539.6 ppt and 76.8 ppt, respectively, for 2006-2009. The enhanced CFC mixing ratios compared to AGAGE sites such as Trinidad Head (THD), US and Mace Head (MHD), Ireland suggest regional influences even during background conditions at SDZ, which is much closer to highly-populated areas. Between 2006 and 2009 background CFCs exhibited downward trends at rates of -2.0 ppt yr -1 for CFC-11, -2.5 ppt yr -1 for CFC-12 and -0.7 ppt yr -1 for CFC-113. De-trended 3-year average background seasonal cycles displayed small fluctuations with peak-to-trough amplitudes of 1.0 ± 0.02 ppt (0.4%) for background CFC-11, 1.3 ± 2.1 ppt (0.3%) for CFC-12 and 0.2 ± 0.4 ppt (0.3%) for CFC-113. On the other hand, during pollution periods these CFCs showed much larger seasonal cycles of 11.2 ± 10.7 ppt (5%) for CFC-11, 7.5 ± 6.5 ppt (2%) for CFC-12 and 1.0 ± 1.2 ppt (1.2%) for CFC-113, with apparent winter minima and early summer maxima. This enhancement was attributed to prevailing wind directions from urban regions in summer and to enhanced anthropogenic sources during the warm season. In general, horizontal winds from northeast showed negative contribution to atmospheric CFCs loading, whereas South Western advection (urban sector: Beijing) had positive contributions.

Zhang, Fang; Zhou, Lingxi; Yao, Bo; Vollmer, Martin. K.; Greally, Brian R.; Simmonds, Peter G.; Reimann, Stefan; Stordal, Frode; Maione, Michela; Xu, Lin; Zhang, Xiaochun

2010-11-01

306

A study of cosmic rays on the artificial moon satellites Luna-11 and Luna-12  

NASA Technical Reports Server (NTRS)

In the period from the end of August 1966 to January 1967 the primary cosmic radiation fluxes beyond the terrestrial magnetosphere were measured by means of the equipment mounted on the satellites Luna-11 and Luna-12. The altitude dependence of cosmic rays near the lunar surface as well as the intensity of protons and electrons of solar origin in the moon's vicinity were determined. The correlation of proton intensity with the parameters characterizing the solar and geomagnetic activities and the specific features of the angular distribution of the proton flux as revealed during measurements are given. Data on electron fluxes studied on September 1 and 8, 1966, when short term increases in the electron intensity were observed are included.

Grigorov, N. L.; Kurt, V. G.; Lutsenko, V. N.; Maduyev, V. L.; Pisarenko, N. F.; Savenko, I. A.

1975-01-01

307

Electron-Ion Recombination of Fe12 + Forming Fe11 +: Laboratory Measurements and Theoretical Calculations  

NASA Astrophysics Data System (ADS)

We have measured dielectronic recombination (DR) for Fe12 + forming Fe11 + using the heavy ion storage ring TSR located at the Max Planck Institute for Nuclear Physics in Heidelberg, Germany. Using our results, we have calculated a plasma rate coefficient from these data that can be used for modeling astrophysical and laboratory plasmas. For the low temperatures characteristic of photoionized plasmas, the experimentally derived rate coefficient is orders of magnitude larger than the previously recommended atomic data. The existing atomic data were also about 40% smaller than our measurements at temperatures relevant for collisionally ionized plasmas. Recent state-of-the-art theory has difficulty reproducing the detailed energy dependence of the DR spectrum. However, for the Maxwellian plasma rate coefficient, recent theoretical results agree with our measurements to within about 30% for both photoionized and collisionally ionized plasmas.

Hahn, M.; Badnell, N. R.; Grieser, M.; Krantz, C.; Lestinsky, M.; Müller, A.; Novotný, O.; Repnow, R.; Schippers, S.; Wolf, A.; Savin, D. W.

2014-06-01

308

Atmospheric Lifetimes and Radiative Forcing of CFC-11 and CFC-12  

NASA Astrophysics Data System (ADS)

Atmospheric lifetimes for chlorofluorocarbons (CFCs) are important for interpreting their temporal trends and for evaluating their impact on stratospheric chemistry and radiative forcing of climate. The lifetimes of CFC-11 and CFC-12 have been evaluated using global observations of their stratospheric distributions from satellite-based instruments between the period 1992 and 2010. The CFC data sets are from the Cryogen Limb Array Etalon Spectrometer (CLAES), the Cryogenic Infrared Spectrometers and Telescopes for the Atmosphere (CRISTA-1 and CRISTA-2), the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS), and the Atmospheric Chemistry Experiment (ACE). Stratospheric loss rates were calculated using an ultraviolet radiative transfer code with updated molecular cross section and solar irradiance data. Infrared radiative forcings (net flux changes at the tropopause) were determined using CFC distributions from the satellite observations.

Minschwaner, Kenneth; Hoffmann, Lars; Brown, Alex; Riese, Martin; Müller, Rolf; Bernath, Peter

2013-03-01

309

Behavior of titanium sublimation and sputter ion pumps in the 10/sup -11/ torr range  

SciTech Connect

In the proposed Intersecting Storage Accelerator, ISABELLE, 1200 pumping stations will be used to keep two 3 km long rings at a pressure of 1 x 10/sup -11/ torr. It is clear that in such a large system, price and simplicity are very important. A study was made on a well instrumented room temperature vacuum system with a surface area of 6000 cm/sup 2/ and a volume of 17 l, pumped by a Ti-ball and an ion pump. Total pressure and residual gas composition were measured by a Helmer gauge and a quadrupole mass spectrometer. The final pressures of approximately 1 x 10/sup -11/ torr were reached with Ti films and a 20 l s/sup -1/ sputter-ion pump. The main residual gas components were hydrogen and methane. The ultimate pressure was determined primarily by the ability of Ti films to pump H/sub 2/ which depends on the method of laying down the film and the surface temperature. Previous surface preparation seemed relatively unimportant. Two methods of pumping CH/sub 4/ were investigated: (1) cracking the molecules on hot tungsten filament; and (2) conventional sputter-ion pumping. Sputter-ion pumping was found to be more efficient and preferable.

Halama, H.J.

1976-01-01

310

Frequency measurements in the 10 ?m spectrum of 11BCl 3  

NASA Astrophysics Data System (ADS)

This paper presents a study of the spectroscopy of 11BCl 3 using the Doppler-free saturated absorption technique. Many lines in the degenerate ? 3 fundamental of this molecule have been recorded using the 10P branch of a carbon dioxide laser. The absolute frequencies of the linecentres of these absorptions have been measured to an accuracy of better than 10 kHz, using frequencies calibrated against transitions in SF 6 and OsO 4. Hyperfine structure due to the Cl nuclei was easily resolved, and more detailed structure, which may be attributed to the 11B quadrupole interaction, was also seen. The splittings between individual quadrupole components were measured to an accuracy of better than 2 kHz where SF 6 references were used, and to about 8 kHz in the case of OsO 4. Peak-to-peak linewidths as low as 22 kHz have been recorded, representing the highest resolution data yet obtained for this molecule.

Godwin, D. P.; Butcher, R. J.

1993-04-01

311

A 12×10 pixels superconducting tunnel junction array based spectro-photometer for optical astronomy  

NASA Astrophysics Data System (ADS)

Superconducting Tunnel Junctions (STJs) have been extensively investigated as photon detectors covering the range from near-infrared to X-ray energies. A 6×6 array of Ta junctions has already been used in an optical spectro-photometer. With this camera, the European Space Agency has performed multiple astronomical observations of optical sources using the William Herschel 4.2m telescope at La Palma. Following the success of this programe, we are now completing the development of a second generation camera. The goals of this programe were to increase the field of view of the instrument from 4''×4'' to 11''×9'', to optimize IR rejection filters (possibly extending the `red' response to ~1?m), and to increase the electronics readout speed. For these purposes, we have developed a new STJ array consisting of 10×12 Ta/Al devices as well as an improved readout system. In this paper, we review the instrument's architecture and describe the performance of the new detector array.

Martin, D. D. E.; Verhoeve, P.; Peacock, A.; van Dordrecht, A.; Verveer, J.; Hijmering, R.

2004-03-01

312

Novel NUP98-HOXC11 fusion gene resulted from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13).  

PubMed

The NUP98 gene has been reported to be fused to 11 partner genes in hematological malignancies with 11p15 translocations. Among NUP98 fusion partner genes, HOXA and HOXD clusters have been reported thus far; however, no HOXC or HOXB clusters have been reported. We identified a novel NUP98-HOXC11 fusion gene in a pediatric patient with de novo acute myeloid leukemia having t(11;12)(p15;q13). The breakpoint of NUP98 was located within a LINE repetitive sequence (HAL1) in intron 12, and the breakpoint of HOXC11 was located within exon 1, resulting in a NUP98-HOXC11 in-frame fusion transcript containing exon 12 of NUP98 fused to a part of exon 1 of HOXC11 with an 8-bp insertion derived from the intron sequence just 5' of the breakpoint of NUP98. The NUP98-HOXC11 fusion protein consists of the NH2-terminal phenylalanine-glycine repeat motif of NUP98 and the COOH-terminal homeodomain of HOXC11. Although the frequency of HOXC11 expression was not high in leukemia cell lines, its expression was significantly more frequent in myeloid than lymphoid leukemia cell lines. These data suggest that the NUP98-HOXC11 fusion protein plays a role in the pathogenesis of myeloid malignancies. PMID:12183408

Taketani, Takeshi; Taki, Tomohiko; Shibuya, Noriko; Kikuchi, Akira; Hanada, Ryoji; Hayashi, Yasuhide

2002-08-15

313

The mechanism of unimolecular decomposition of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane. A computational DFT study.  

PubMed

By using the B3LYP level of density functional theory, possible decomposition reaction pathways of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) in the gas phase have been investigated. We have found several types of reactions for this process: homolytic cleavage of an N-N bond to form the NO2* group; HONO elimination; C-C and C-N bonds breaking leading to ring opening; and H-migration. On the basis of the results of computation scanning of the potential energy surface, the most favorite pathway of CL-20 unimolecular decomposition that results in the formation of the stable aromatic compound 1,5-dihydrodiimidazo[4,5-b:4',5'-e]pyrazine has been proposed. PMID:16833616

Okovytyy, Sergiy; Kholod, Yana; Qasim, Mohammad; Fredrickson, Herbert; Leszczynski, Jerzy

2005-03-31

314

Novel application of 1-\\/2-phenyl substituted 9,10-anthraquinones in solid electrochromic devices  

Microsoft Academic Search

1-\\/2-phenyl substituted 9,10-anthraquinones were synthesized via Suzuki coupling reactions of 1-\\/2-iodo-9,10-anthraquinones\\u000a with benzeneboronic acid. They are efficient and reversible electrochromic materials and their solid electrochromic devices\\u000a were prepared. When reduced, the device color of 1-phenyl-9,10-anthraquinone shifts from yellow to claret while that of 2-phenyl-9,10-anthraquinone\\u000a switches from yellow-green to a dark blue-purple. Their different characteristics and behaviors in electrochromic devices\\u000a are

Binglin Sui; Xiangkai Fu

2009-01-01

315

10 CFR 11.15 - Application for special nuclear material access authorization.  

Code of Federal Regulations, 2010 CFR

...Application for special nuclear material access authorization. 11.15 Section 11...PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...Requirements for Special Nuclear Material Access Authorization § 11.15...

2009-01-01

316

The tyrosinase-positive oculocutaneous albinism locus maps to chromosome 15q11.2-q12.  

PubMed Central

Tyrosinase-positive oculocutaneous albinism (ty-pos OCA), an autosomal recessive disorder of the melanin biosynthetic pathway, is the most common type of albinism occurring worldwide. In southern African Bantu-speaking negroids it has an overall prevalence of about 1/3,900. Since the basic biochemical defect is unknown, a linkage study with candidate loci, candidate chromosomal regions, and random loci was undertaken. The ty-pos OCA locus was found to be linked to two arbitrary loci, D15S10 and D15S13, in the Prader-Willi/Angelman chromosomal region on chromosome 15q11.2-q12. The pink-eyed dilute locus, p, on mouse chromosome 7, maps close to a region of homology on human chromosome 15q, and we postulate that the ty-pos OCA and p loci are homologous.

Ramsay, M; Colman, M A; Stevens, G; Zwane, E; Kromberg, J; Farrall, M; Jenkins, T

1992-01-01

317

75 FR 35354 - Airworthiness Directives; Honeywell International Inc. TPE331-10 and TPE331-11 Series Turboprop...  

Federal Register 2010, 2011, 2012, 2013

...2120-AA64 Airworthiness Directives; Honeywell International Inc. TPE331-10 and TPE331-11...existing airworthiness directive (AD) for Honeywell International Inc. TPE331-10 and TPE331-11...and approved the technical contents of Honeywell International Inc. Alert Service...

2010-06-22

318

Technical Review Report for the Justification for 9975 Gram Based Content Envelopes, C.10 and C.11.  

National Technical Information Service (NTIS)

The Department of Energy (DOE) desires to ship Model 9975-85 and Model 9975-96 Packages loaded with Pu/U metal and Pu/U oxide materials as identified in new Content Envelopes C.10 and C.11. The new Content Envelopes C.10 and C.11 consist of radioisotopes ...

M. West

2009-01-01

319

12 CFR 1263.10 - Ten percent requirement for certain insured depository institution applicants.  

Code of Federal Regulations, 2012 CFR

12 Banks and Banking 9 2012-01-01 2012-01-01 false Ten percent...subject to the 10 percent requirement of section 4(a)(2)(A) of the Bank Act (12 U.S.C. 1424(a)(2)(A)) and § 1263.6(b) shall be deemed to...

2012-01-01

320

10. INTERIOR OF SOUTH SIDE ENCLOSED SCREEN PORCH SHOWING 1/2 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. INTERIOR OF SOUTH SIDE ENCLOSED SCREEN PORCH SHOWING 1/2 SCREEN DOOR TO EXTERIOR AND DOUBLE FRENCH DOORS TO DINING ROOM. HOLE AT BOTTOM LEFT OF 1/2 SCREEN DOOR WAS A CAT DOOR. VIEW TO EAST. - Big Creek Hydroelectric System, Powerhouse 8, Operator Cottage, Big Creek, Big Creek, Fresno County, CA

321

Vertical profiles of CCl3F (F-11) and CCl2F2 (F-12) in the central Arctic Ocean basin  

NASA Astrophysics Data System (ADS)

The anthropogenic chlorofluoro-methanes CCl3F (F-11) and CCl2F2 (F-12) have been measured to depths of 1800 m in the Canada Basin of the Arctic Ocean (approximate position 85°50'N, 108°50'W). The measurements were made as part of the Canadian Expedition to Study the Alpha Ridge (CESAR) during April 1983. Surface layer concentrations beneath the ice were 4.79×10-12 mol/kg (F-11) and 2.11×10-12 mol/kg (F-12). Both profiles exhibit a rapid concentration decrease with depth through the halocline and very low, but detectable, concentrations at depths of 350-900 m in the Atlantic Layer. In the Arctic Ocean Deep Water (900-1800 m), concentrations are at or below our practical detection limit of 0.01×10-12 mol/kg. The profiles have been interpreted using two "extreme-case" lateral ventilation models in order to place bounds on the water column ventilation rates. The "Ventilation age" of the upper portion of the halocline (60-150 m) increases with depth from 4 to 14 years. The core of the Atlantic Layer at this location appears to have been isolated from the surface for at least 30 years.

Wallace, Douglas W. R.; Moore, Robert M.

1985-01-01

322

High precision 11B/10B analysis with a simplified MC-ICP-MS  

NASA Astrophysics Data System (ADS)

Boron isotope ratio is a powerful tracer in the fields of geochemistry, biochemistry, and environmental chemistry. One important application of 11B/10B isotope ratio in geochemistry is as an indicator for paleo pH of seawater recorded in marine carbonates in deep-sea sediments. Boron isotope ratios are determined by TIMS or MC-ICP-MS with precisions of better than 0.1 % RSD, but a large inter-lab discrepancy of 0.6 % is still observed for actual carbonate samples (Foster, 2008). Here, we tried to determine B isotope ratio by MC-ICP-MS with a simple and common analytical techniques using a quartz sample introduction system with a PFA nebulizer, and compared to recently developed precise B isotope ratio analysis techniques by TIMS in positive ion detection mode determined as Cs2BO2+ ions with sample amount of <100 ng (Ishikawa and Nagaishi, 2011) and by MC-ICP-MS (Foster, 2008, Louvat et al., 2011). 11B/10B isotope ratios of a 50 ppb B solution dissolved in a HNO3, mannitol, HF-mixed solution were determined against an isotopic reference NIST-SRM 951 with a standard sample bracketing technique in the wet plasma condition. Resultant analytical reproducibility (twice standard deviation) was +/-0.02 % with a consumption of 50 ng B, and the washout time was comparable to that of NH3 gas addition to the introduction system (Foster, 2008). 11B/10B isotope ratios of actual carbonate sample and seawater were determined after simple chemical purification with a common cation exchange resin instead of a boron selective resin. Their relative differences from the standard were consistent with those determined by the positive TIMS within analytical uncertainty. Current potential of MC-ICP-MS for precise B isotopic analysis will be discussed. Foster, G., 2008. Seawater pH, pCO2 and [CO32-] variations in the Caribbean Sea over the last 130kyr: A boron isotope and B/Ca study of planktic foraminifera, Earth Planet. Sci. Lett., 271, 254-266. Ishikawa, T. and Nagaishi, K., 2011. High-precision isotopic analysis of boron by positive thermal ionization mass spectrometry with sample preheating, J. Anal. At. Spectrom., 26, 359-365. Louvat, P., Bouchez, J, and Paris, G., 2011. MC-ICP-MS isotope measurements with direct injection nebulisation (d-DIHEN): Optimisation and application to boron in seawater and carbonate samples., Geostand. Geoanal. Res., 35, 75-88.

Tanimizu, M.; Nagaishi, K.

2012-04-01

323

Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis.  

PubMed

Ten AML-M4/M5 patients' samples containing a t(10;11) translocation, but with different cytogenetic breakpoints on chromosome 11q (11q13-23), were studied by G- and R-banding and fluorescent in situ hybridization. Southern blotting analysis, studied in five patients, revealed a rearranged MLL gene. Reverse transcription-PCR analysis carried out in six patients showed a 5' MLL-3' AF-10 fusion transcript. Fluorescent in situ hybridization studies suggested that in 8 of 10 patients, the rearrangement/fusion transcript resulted from an inversion of a part of 11q (q13q23) translocated to 10p12. In the other two patients, it is assumed that an inversion/translocation has occurred of a part of 10p to the der(11). The results suggest that the orientation of the AF-10 gene on 10p is 5' telomeric and 3' centromeric. This is the first example of opposite-oriented genes being involved in translocation to yield fusion transcripts. PMID:7671224

Beverloo, H B; Le Coniat, M; Wijsman, J; Lillington, D M; Bernard, O; de Klein, A; van Wering, E; Welborn, J; Young, B D; Hagemeijer, A

1995-10-01

324

41 CFR 302-12.10 - What are the income tax consequences if I use a relocation services company?  

Code of Federal Regulations, 2013 CFR

...consequences if I use a relocation services company? 302-12.10 Section 302-12.10 Public Contracts and Property Management Federal...RELOCATION ALLOWANCES RESIDENCE TRANSACTION ALLOWANCES 12-USE OF A RELOCATION SERVICES COMPANY...

2013-07-01

325

Asymmetric conversions of 10-bromo-10,11-dihydroquinines into 8-oxa-1-azabicyclo[4.3.0]nonane derivatives and related compounds  

Microsoft Academic Search

Some transformations of (10R)- and (10S)-bromo-10,11-dihydroquinine 2a and 2b have been investigated in order to obtain insights into their unexplored chirality. The (10R)-diastereomer 2a converts stereoselectively into (4S)-(E-propenyl)-(6S,7R)-(6-methoxy-quinol-4-yl)-8-oxa-(1R)-azabicyclo[4.3.0]nonane 10, which is the product of a novel rearrangement of the parent quinine 1 and displays the N(1)-(S)-configuration (10a) in the solid state. The (10S)-diastereomer 2b afforded 10 and its (Z)-propenyl isomer

Jacek Thiel; Andrzej Katrusiak

2002-01-01

326

t(10;11)-acute leukemias with MLL-AF10 and MLL-ABI1 chimeric transcripts: specific expression patterns of ABI1 gene in leukemia and solid tumor cell lines.  

PubMed

The recurrent translocation t(10;11) is associated with acute myeloid leukemia (AML). The AF10 gene on chromosome 10 at band p12 and MLL at 11q23 fuse in the t(10;11)(p12;q23). Recently, we have identified ABI1 as a new partner gene for MLL in an AML patient with a t(10;11)(p11.2;q23). The ABI1 is a human homologue of the mouse Abl-interactor 1 (Abi1), encoding an Abl-binding protein. The ABI1 protein exhibits sequence similarity to homeotic genes, and contains several polyproline stretches and a src homology 3 (SH3) domain. To clarify the clinical features of t(10;11)-leukemias, we investigated 6 samples from acute leukemia patients with t(10;11) and MLL rearrangement and detected MLL-AF10 chimeric transcripts in 5 samples and MLL-ABI1 in one. The patient with MLL-ABI1 chimeric transcript is the second case described, thus confirming that the fusion of the MLL and ABI1 genes is a recurring abnormality. Both of the patients with MLL-ABI1 chimeric transcript are surviving, suggesting that these patients have a better prognosis than the patients with MLL-AF10. To investigate the roles of AF10 and ABI1 further, we examined the expression of these genes in various cell lines and fresh tumor samples using the reverse transcriptase-polymerase chain reaction method. Although AF10 was expressed in almost all cell lines similarly, the expression patterns of ABI1 were different between leukemia and solid tumor cell lines, suggesting the distinctive role of each isoform of ABI1 in these cell lines. We also determined the complete mouse Abi1 sequence and found that the sequence matched with human ABI1 better than the originally reported Abi1 sequence. Further functional analysis of the MLL-AF10 and MLL-ABI1 fusion proteins will provide new insights into the leukemogenesis of t(10;11)-AML. PMID:11477655

Shibuya, N; Taki, T; Mugishima, H; Chin, M; Tsuchida, M; Sako, M; Kawa, K; Ishii, E; Miura, I; Yanagisawa, M; Hayashi, Y

2001-09-01

327

trans-10,cis-12 conjugated linoleic acid enhances endurance capacity by increasing fatty acid oxidation and reducing glycogen utilization in mice.  

PubMed

The supplementation of conjugated linoleic acid (CLA) has been shown to improve endurance by enhancing fat oxidation during exercise in rodents and humans. This study was designed to investigate the isomer-specific effects of CLA on endurance capacity and energy metabolism in mice during exercise. Male 129Sv/J mice were divided into three dietary groups and fed treatment diet for 6 weeks; control, 0.5 % cis-9,trans-11 (c9,t11) CLA, or 0.5 % trans-10,cis-12 (t10,c12) CLA. Dietary t10,c12 CLA induced a significant increase in maximum running time and distance until exhaustion with a dramatic reduction of total adipose depots compared to a control group, but there were no significant changes in endurance with the c9,t11 CLA treatment. Serum triacylglycerol and non-esterified fatty acid concentrations were significantly lower in the t10,c12 fed mice after exercise compared to control and the c9,t11 CLA fed-animals. Glycogen contents in livers of the t10,c12 fed-mice were higher than those in control mice, concomitant with reduction of serum L-lactate level. There were no differences in non-exercise physical activity among all treatment groups. In addition, the mRNA expression levels of carnitine palmitoyl transferase 1?, uncoupling protein 2 and peroxisome proliferator-activated receptor ? (PPAR?) in skeletal muscle during exercise were significantly up-regulated by the t10,c12 CLA but not the c9,t11 CLA. These results suggest that the t10,c12 CLA is responsible for improving endurance exercise capacity by promoting fat oxidation with a reduction of the consumption of stored liver glycogen, potentially mediated via PPAR? dependent mechanisms. PMID:22782371

Kim, Jun Ho; Kim, Jonggun; Park, Yeonhwa

2012-09-01

328

S-(-)-10,11-dihydroxyfarnesoic Acid methyl ester inhibits melanin synthesis in murine melanocyte cells.  

PubMed

The development of antimelanogenic agents is important for the prevention of serious aesthetic problems such as melasmas, freckles, age spots, and chloasmas. In the course of screening for melanin synthesis inhibitors, we found that the culture broth from an insect morphopathogenic fungus, Beauveria bassiana CS1029, exhibits potent antimelanogenic activity. We isolated and purified an active metabolite and identified it as S-(-)-10,11-dihydroxyfarnesoic acid methyl ester (dhFAME), an insect juvenile hormone. To address whether dhFAME inhibits melanin synthesis, we first measured the size of the melanin biosynthesis inhibition zone caused by dhFAME. dhFAME also showed inhibitory activity against mushroom tyrosinase in Melan-a cells. Intracellular, dose-dependent tyrosinase inhibition activity was also confirmed by zymography. In addition, we showed that dhFAME strongly inhibits melanin synthesis in Melan-a cells. Furthermore, we compared levels of TYR, TRP-1, TRP-2, MITF, and MC1R mRNA expression by reverse-transcription polymerase chain reaction and showed that treatment of Melan-a cells with 35 ?M dhFAME led to an 11-fold decrease in TYR expression, a 6-fold decrease in TRP-2 expression, and a 5-fold decrease in MITF expression. Together, these results indicate that dhFAME is a potent inhibitor of melanin synthesis that can potentially be used for cosmetic biomaterial(s). PMID:25046747

Baek, Seung-Hwa; Ahn, Jun-Won; Nam, Sung-Hee; Yoon, Cheol-Sik; Shin, Jae-Cheon; Lee, Sang-Han

2014-01-01

329

Radial variation of interplanetary Alfvenic fluctuations Pioneer 10 and 11 observations between 1 and 5 AU  

NASA Technical Reports Server (NTRS)

The radial evolution of the power spectra of Alfvenic fluctuations observed within the trailing edge of high speed streams in the solar wind has been investigated using magnetic field measurements by Pioneer 10 and Pioneer 11 at heliocentric distances between 1 and 5 AU. In the analyzed frequency range (0.00028 - 0.0083 Hz) the spectral index of the computed spectra does not depend on frequency and is close to the value predicted for hydrodynamic turbulence. The radial gradient of the power density is independent of frequency and only slightly steeper than that expected for undamped propagation of Alfvenic fluctuations in a rarefaction region. The relation between the present results and those previously obtained by Helios 1 and 2 inside 1 AU is discussed.

Bavassano, B.; Smith, E. J.

1986-01-01

330

Sperm FISH and chromatin integrity in spermatozoa from a t(6;10;11) carrier.  

PubMed

Complex chromosome rearrangements (CCRs) are structurally balanced or unbalanced aberrations involving more than two breakpoints on two or more chromosomes. CCRs can be a potential reason for genomic imbalance in gametes, which leads to a drastic reduction in fertility. In this study, the meiotic segregation pattern, aneuploidy of seven chromosomes uninvolved in the CCR and chromatin integrity were analysed in the ejaculated spermatozoa of a 46,XY,t(6;10;11)(q25.1;q24.3;q23.1)mat carrier with asthenozoospermia and a lack of conception. The frequency of genetically unbalanced spermatozoa was 78.8% with a prevalence of 4:2 segregants of 38.2%, while the prevalence of the adjacent 3:3 mode was 35.3%. Analysis of the aneuploidy of chromosomes 13, 15, 18, 21, 22, X and Y revealed an approximately fivefold increased level in comparison with that of the control group, indicating the presence of an interchromosomal effect. Sperm chromatin integrity status was evaluated using chromomycin A3 and aniline blue staining (deprotamination), acridine orange test and TUNEL assay (sperm DNA fragmentation). No differences were found when comparisons were made with a control group. We suggest that the accumulation of genetically unbalanced spermatozoa, significantly increased sperm aneuploidy level and decreased sperm motility (20%, progressive) were not responsible for the observed lack of reproductive success in the analysed infertile t(6;10;11) carrier. Interestingly, in the case described herein, a high level of sperm chromosomal imbalance appears not to be linked to sperm chromatin integrity status. PMID:24713394

Olszewska, Marta; Huleyuk, Nataliya; Fraczek, Monika; Zastavna, Danuta; Wiland, Ewa; Kurpisz, Maciej

2014-05-01

331

Logrithmic current simulator generates electrical currents accurately between 10 to the minus 11 ampere to 10 to the minus 3 ampere  

NASA Technical Reports Server (NTRS)

Current generator accurately simulates electric currents in the range of 10 to the minus 11th power to 0.001 ampere. Compensation networks have been devised to improve the accuracy at the lower current levels.

Wilson, J.

1966-01-01

332

Structure of Sorting Nexin 11 (SNX11) Reveals a Novel Extended Phox Homology (PX) Domain Critical for Inhibition of SNX10-induced Vacuolation*  

PubMed Central

Sorting nexins are phox homology (PX) domain-containing proteins involved in diverse intracellular endosomal trafficking pathways. The PX domain binds to certain phosphatidylinositols and is recruited to vesicles rich in these lipids. The structure of the PX domain is highly conserved, containing a three-stranded ?-sheet, followed by three ?-helices. Here, we report the crystal structures of truncated human SNX11 (sorting nexin 11). The structures reveal that SNX11 contains a novel PX domain, hereby named the extended PX (PXe) domain, with two additional ?-helices at the C terminus. We demonstrate that these ?-helices are indispensible for the in vitro functions of SNX11. We propose that this PXe domain is present in SNX10 and is responsible for the vacuolation activity of SNX10. Thus, this novel PXe domain constitutes a structurally and functionally important PX domain subfamily.

Xu, Jinxin; Xu, Tingting; Wu, Bin; Ye, Yinghua; You, Xiaojuan; Shu, Xiaodong; Pei, Duanqing; Liu, Jinsong

2013-01-01

333

[Experiments on suture material prolene 10-0 and vicryl 11-0 compared with nylon 10-0 in the rabbit cornea (author's transl)].  

PubMed

Synthetic absorbable suture material Vicryl 11-0 and not absorbable Prolene 10-0 are tolerated well by the corneal tissue as compared with nylon 10-0. Vicryl 11-0 sutures remained intact for only 13.2 days on an average, this is too short for normal corneal surgery. As nylon shows signs of absorption with time Prolene may be preferable to nylon where permanent sutures are necessary. PMID:886803

Faulborn, J; Theopold, H

1977-04-01

334

Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid.  

PubMed

We showed the inhibitory effect of oleic and palmitoleic acids (OA and POA) on this trans10, cis12 (10t, 12c)-CLA induced cytotoxic activity. When cells were cultured in the presence of 10t, 12c-CLA, this potent cytotoxic effect on dRLh-84 cells was clearly obvious when compared to the control vehicle group. It was revealed that the levels of cellular OA and POA levels decreased upon cis9, trans11 (9c,11t) or 10t, 12c-CLA treatment in a time course dependent manner. OA or POA demonstrates a dose dependent inhibition of the 10t, 12c-CLA induced cytotoxicity. Notable nuclear fragmentation or activation of caspase-3 and 9 by 10t, 12c-CLA in dRLh-84 was counteracted by treatment with OA or POA. Results also suggest that 10t, 12c-CLA induced apoptosis can be inhibited by treatment with OA or POA. PMID:12860277

Yamasaki, Masao; Chujo, Hitomi; Nou, Shinsuke; Tachibana, Hirofumi; Yamada, Koji

2003-07-10

335

Shuttle cryogenic supply system optimization study. Volume 3: Technical report, section 10, 11 and 12  

NASA Technical Reports Server (NTRS)

The evaluation of candidate cryogenic fuel systems for space shuttle vehicles is discussed. A set of guidelines was used to establish a matrix of possible combinations for the integration of potential cryogenic systems. The various concepts and combinations which resulted from the integration efforts are described. The parameters which were considered in developing the matrix are: (1) storage of cryogenic materials, (2) fuel lines, (3) tank pressure control, (4) thermal control, (5) fluid control, and (6) fluid conditioning. Block diagrams and drawings of the candidate systems are provided. Performance predictions for the systems are outlined in tables of data.

1973-01-01

336

Acta Ornithologica. Volume 10, Number 1-2, 5-11, 1967.  

National Technical Information Service (NTIS)

Contents: Contributions to the avifauna of Kartuzy District; Breeding colonies of the Bee-eater near Przemysl; Water birds on the Vistula near Krakow in 1962-1965; Water and marsh birds observed during a flood near Leszno, Prov. Poznan; The first record o...

1972-01-01

337

Ethyl trans-12-(pyridin-4-yl)-9,10-ethano-anthracene-11-carboxyl-ate  

PubMed Central

In the title compound, C24H21NO2, the residues at the central ethyl­ene bridge are trans to each other. The dihedral angles between the pyridine and benzene rings are 67.09?(6) and 61.41?(5)°. In the crystal, centrosymmetrically related mol­ecules are linked into dimers by pairs of C—H?O hydrogen bonds.

Chandrasekar, S.; Sharma Om, Prakash; Srinivasapriyan, V.; SureshKumar, M.; Ramanathan, C. R.

2014-01-01

338

Ethyl trans-12-(pyridin-4-yl)-9,10-ethano-anthracene-11-carboxyl-ate.  

PubMed

In the title compound, C24H21NO2, the residues at the central ethyl-ene bridge are trans to each other. The dihedral angles between the pyridine and benzene rings are 67.09?(6) and 61.41?(5)°. In the crystal, centrosymmetrically related mol-ecules are linked into dimers by pairs of C-H?O hydrogen bonds. PMID:24860327

Chandrasekar, S; Sharma Om, Prakash; Srinivasapriyan, V; SureshKumar, M; Ramanathan, C R

2014-05-01

339

Immunomodulating treatment with low dose interleukin-4, interleukin-10 and interleukin-11 in psoriasis vulgaris.  

PubMed

Psoriasis is a chronic inflammatory skin disease affecting approximately 2-3 percent of the world population; it is characterised by hyperproliferation and hyperplasia of the superficial layers of the epidermis. Inappropriate signals released by the immune system determine an altered keratinocyte differentiation, resulting in the formation of desquamating, thickened, inflamed and erythematous plaques. The aim of this investigation was to study the pharmacological activity and safety of three low dose cytokines, Guna-Interleukin 4, Guna-Interleukin 10 and Guna-Interleukin 11 at the concentration of 10 fg/ml in patients affected by moderate to slight psoriasis vulgaris. The multicenter, double-blind, randomized, placebo-controlled clinical trial involved 48 patients who were enrolled and followed up according to a 8-month experimental project. All patients received, according to a cross-over model, either the experimental treatment or placebo, alternatively. Globally, in the 41 evaluated patients it was observed a PASI significant reduction (Friedman test: p=0.00960). The DLQI too decreased significantly in all subjects compared to baseline (Friedman test: p=0.00007). The safety of the treatment with three low dose cytokines administered simultaneously was proved; no adverse event was reported during the whole trial. PMID:24750799

Roberti, M L; Ricottini, L; Capponi, A; Sclauzero, E; Vicenti, P; Fiorentini, E; Savoia, C; Scornavacca, G; Brazioli, D; Gaio, L; Giannetti, R; Ignazzi, C; Meloni, G; Chinni, L M

2014-01-01

340

Hydrolysis of Nothogenia erinacea xylan by xylanases from families 10 and 11.  

PubMed

The structures of several enzymatic hydrolysis products of Nothogenia erinacea seaweed xylan, a linear homopolymer with mixed beta-(1-->3)/beta-(1-->4) linkages, were analysed by physicochemical and biochemical techniques. With the glycoside hydrolase family 10 beta-(1-->4)-xylanase from Cryptococcus adeliae, hydrolysis proceeds to a final mixture of products containing a mixed linkage-type triose as a major compound, whereas with the family 11 xylanase from Thermomyces lanuginosus this is a mixed linkage tetraose. The Cryptococcus xylanase is shown to be capable of also catalysing the hydrolysis of beta-(1-->3) linkages, that is this of a mixed type tetraose intermediary formed, in accordance with the broader substrate specificity of family 10 enzymes. From a partial degradation experiment with the T. lanuginosus xylanase, a series of higher mixed oligosaccharides were isolated and identified. The observed oligosaccharide intermediates and splicing pattern indicate an irregular beta-(1-->3)/beta-(1-->4) linkage distribution within the linear d-xylose polymer. Similar results were obtained with rhodymenan, the seaweed xylan from Palmares palmata. PMID:15063191

Nerinckx, Wim; Broberg, Anders; Duus, Jens Ø; Ntarima, Patricia; Parolis, Lesley A S; Parolis, Haralambos; Claeyssens, Marc

2004-04-28

341

1-Trimethylamino-1-Beryl-2,3-Dicarbacloso Dodecaborane(12). An Analog of the B11CH12(-) ion.  

National Technical Information Service (NTIS)

The reaction of B9C2H13 with dimethylberyllium in diethyl ether solution produces 2 moles of methane and the compound B9C2BeH11.O(C2H5)2. Reaction of the ether complex with trimethylamine leads to the displacement of diethyl ether and the formation of the...

G. Popp M. F. Hawthorne

1968-01-01

342

Synthesis and biological evaluation of 10-(11) C-dihydrotetrabenazine as a vesicular monoamine transporter 2 radioligand.  

PubMed

In this study, we synthesized a new carbon-11-labeled radiotracer, 10-(11) C-dihydrotetrabenazine (10-(11) C-DTBZ), and evaluated its potential as a vesicular monoamine transporter 2 (VMAT2) radioligand. The radiolabeled precursor 10-O-desmethyl-dihydrotetrabenazine (10-O-desmethyl-DTBZ) was prepared with a six-step reaction using 3-methoxy-4-benzyloxybenzaldehyde as starting material. 10-(11) C-DTBZ was synthesized by heating 1.0?mg of 10-hydroxy precursor and (11) C-methyl iodide in the presence of 0.3?mL of dimethyl sulfoxide and 4.0?µL of 3?N KOH at room temperature for 3?min. After purification by solid phase extraction using an alumina Sep-Pak cartridge, the final 10-(11) C-DTBZ product was obtained with a radiochemical purity of >99% and an uncorrected radiochemical yield of 18-26% (end of bombardment (EOB), n?=?6). The overall synthesis time was approximately 20?min from the EOB to release of the product for quality control. Using small-animal positron emission tomography (microPET), the striatum of normal rats was found to exhibit symmetrical labeling (STR /STL ?=?0.98?±?0.05, n?=?3) and the highest uptake of radioactivity (striatum/cerebellum, ST/CB?=?2.89?±?0.31 at 30-60?min, n?=?3). In contrast, rats with 6-hydroxydopamine unilateral lesions yielded asymmetrical striatal images with a higher 10-(11) C-DTBZ concentration on the unlesioned side (STunlesioned /CB?=?2.53?±?0.18, at 30-60?min, n?=?3) compared with the lesioned side (STlesioned /CB?=?1.26?±?0.10, n?=?3). These results suggest that 10-(11) C-DTBZ may represent a promising PET radiotracer for imaging VMAT2. PMID:24497196

Li, Xiaomin; Chen, Zhengping; Tang, Jie; Liu, Chunyi; Zou, Pei; Huang, Hongbo; Tan, Cheng; Yu, Huixin

2014-05-01

343

The High-Resolution Spectrum of Water Vapor between 11 600 and 12 750 cm-1  

PubMed

The absorption spectrum of water vapor has been recorded between 11 600 and 12 750 cm-1 with a Fourier transform spectrometer (Kitt Peak, Az) at a resolution of 0.012 cm-1 and with a path length of 434 m. The line assignment has led to the determination of 506 accurate energy levels of the (310) (211), (112), (013), (230), (131), (032), and (051) vibrational states which belong to the so-called 3nu + delta resonance polyad. The rotational energy levels obtained are on the average in agreement with those reported recently by R. Toth (J. Mol. Spectrosc. 166, 176-183 (1994)) for the strong bands, but there are differences for high J levels or weak bands levels (about 15% of all levels). The experimental rotational energy levels have been fitted using Pade-Borel approximants and a set of 104 vibrational energies and rotational, resonance, and centrifugal distortion constants for the (310), (211), (112), (013), (230), (131), (032), and (051) vibrational states have been determined. PMID:9252301

Flaud; Camy-Peyret; Bykov; Naumenko; Petrova; Scherbakov; Sinitsa

1997-06-01

344

SOFIA observations of CO (12-11) emission along the L1157 bipolar outflow  

NASA Astrophysics Data System (ADS)

Context. Carbon monoxide is an excellent tracer of the physical conditions of gas in molecular outflows from young stars. Aims: To understand the outflow mechanism we need to investigate the origin of the molecular emission and the structure and interaction of the outflowing molecular gas. Deriving the physical parameters of the gas will help us to trace and understand the various gas components in the flow. Methods: We observed CO (12-11) line emission at various positions along the L1157 bipolar outflow with GREAT aboard SOFIA. Results: Comparing these new data with CO (2-1), we find basically constant line ratios along the outflow and even at the position of the source. These line ratios lead us to estimates of 105 to 106 cm-3 for the gas density and 60 to 100 K for the gas temperature of the outflowing gas. Conclusions: The constrained density and temperature values indicate that we are mostly tracing a low-velocity gas component everywhere along the outflow, which is intermediate between the already known cold gas component, which gets entrained into the flow, and the hot gas, which gets shocked in the outflow.

Eislöffel, J.; Nisini, B.; Güsten, R.; Wiesemeyer, H.; Gusdorf, A.

2012-06-01

345

Effect of intramural myomectomy on endometrial HOXA10 and HOXA11 mRNA expression at the time of implantation window  

PubMed Central

Background: HOXA11 and HOXA10 are expressed in endometrium throughout the menstrual cycle and show a dramatic increase during the mid-luteal phase at the time of implantation. The expression of these genes is decreased in women with myomas. Objective: To determine whether myomectomy would reverse HOXA11 and HOXA10 expression, we evaluated the transcript levels of these genes in the endometria of patients before and after myomectomy. Materials and Methods: Expression of HOXA11 and HOXA10 were examined prospectively during the midluteal phase in endometrium obtained from infertile women (n=12) with myoma before and three months after myomectomy. Endometrial HOXA11 and HOXA10 expression were evaluated using quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Results: Endometrial HOXA11 and HOXA10 mRNAs expression levels (normalized to 18SrRNA) were increased insignificantly in endometrium of patients after myomectomy (p=0.7 and p=0.15 respectively). Conclusion: The results suggest that the alteration in expression pattern of these genes could not account for some aspects of fertility after myomectomy. This article extracted from M.Sc. thesis. (Shamila Faramarzi)

Alizadeh, Zohreh; Faramarzi, Shamila; Saidijam, Massoud; Alizamir, Tahereh; Esna-Ashari, Farzaneh; Shabab, Nooshin; Farimani Sanoee, Marzieh

2013-01-01

346

12 CFR 1026.11 - Treatment of credit balances; account termination.  

...2014-01-01 2014-01-01 false Treatment of credit balances; account termination. 1026.11...TRUTH IN LENDING (REGULATION Z) Open-End Credit § 1026.11 Treatment of credit balances; account termination. (a)...

2014-01-01

347

12 CFR 226.11 - Treatment of credit balances; account termination.  

...2014-01-01 2014-01-01 false Treatment of credit balances; account termination. 226.11 ...TRUTH IN LENDING (REGULATION Z) Open-End Credit § 226.11 Treatment of credit balances; account termination. (a)...

2014-01-01

348

The inv(11)(p15q22) chromosome translocation of therapy-related myelodysplasia with NUP98-DDX10 and DDX10-NUP98 fusion transcripts.  

PubMed

Chromosomal abnormalities involving the 11p15 or 11q22-23 bands have been reported in several types of human neoplasms including hematopoietic malignancies. The abnormalities are observed in therapy-related malignancies and less frequently in de novo myeloid malignancies. Abnormality of the MLL gene located on chromosome 11q23 has been well known in therapy-related myeloid malignancies, but it has been reported only recently that the inv(11)(p15q22) in de novo or therapy-related myeloid malignancies results in the fusion of NUP98 on chromosome 11p15 and DDX10 on chromosome 11q22. NUP98 is a nucleoporin that composes the nuclear pore complex and is the target gene in leukemia with the t(7;11)(p15;p15). The DDX10 gene encodes a putative adenosine triphosphate-dependent DEAD box RNA helicase. Here we present another patient with acute myelocytic leukemia (M4) transformed from chronic myelomonocytic leukemia with the inv(11) chromosome who had been treated with etoposide for a germ cell tumor. By reverse transcription polymerase chain reaction (RT-PCR) of the RNA from the leukemic cells of the patient, DDX10-NUP98 and NUP98-DDX10 fusion transcripts were detected. Our case confirms that the inv(11) is a rare chromosomal translocation that is associated with therapy-related or de novo myeloid malignancy and involves NUP98 and DDX10 but not MLL. RT-PCR of the fusion transcripts might be applied to the detection of a small number of leukemic cells in the bone marrow or blood of patients in remission or in the cells harvested for autologous transplantation. PMID:10222653

Ikeda, T; Ikeda, K; Sasaki, K; Kawakami, K; Takahara, J

1999-04-01

349

10 CFR 100.11 - Determination of exclusion area, low population zone, and population center distance.  

Code of Federal Regulations, 2010 CFR

...false Determination of exclusion area, low population zone, and population center distance. 100.11 Section 100...11 Determination of exclusion area, low population zone, and population center distance....

2012-01-01

350

10 CFR 851.11 - Development and approval of worker safety and health program.  

...Development and approval of worker safety and health program. 851.11 Section 851.11...DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Program Requirements § 851...Development and approval of worker safety and health program. (a) Preparation and...

2014-01-01

351

10 CFR 11.15 - Application for special nuclear material access authorization.  

Code of Federal Regulations, 2013 CFR

...Application for special nuclear material access authorization. 11.15 Section...FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...Requirements for Special Nuclear Material Access Authorization § 11.15...

2014-01-01

352

Genetic engineering of Yarrowia lipolytica for enhanced production of trans-10, cis-12 conjugated linoleic acid  

PubMed Central

Background Conjugated linoleic acid (CLA) has been extensively studied for decades because of its health benefits including cancer prevention, anti-atherogenic and anti-obesity effects, and modulation of the immune system. We previously described the production of trans-10, cis-12 CLA in Yarrowia lipolytica by expressing the gene coding for linoleic acid isomerase from Propionibacterium acnes (pai). However the stable strain produced CLA at about 0.08% of dry cell weight (DCW), a level of production which was not high enough for practical applications. The goal of the present study was to enhance production of CLA by genetic engineering of Y. lipolytica strains. Results We have now co-expressed the delta 12-desaturase gene (FADS12, d12) from Mortierella alpina together with the codon-optimized linoleic acid isomerase (opai) gene in Y. lipolytica, expressed under the control of promoter hp16d modified by fusing 12 copies of UAS1B to the original promoter hp4d. A multi-copy integration plasmid was used to further enhance the expression of both genes. Using glucose as the sole carbon source, the genetically-modified Y. lipolytica produced trans-10, cis-12-CLA at a level of up to 10% of total fatty acids and 0.4% of DCW. Furthermore, when the recombinant yeast was grown with soybean oil, trans-10, cis-12-CLA now accumulated at a level of up to 44% of total fatty acids, which represented 30% of DCW after 38.5 h of cultivation. In addition, trans-10, cis-12-CLA was also detected in the growth medium up to 0.9 g/l. Conclusions We have successfully produced trans-10, cis-12-CLA with a titre of 4 g/l of culture (3.1 g/l in cells and 0.9 g/l in culture medium). Our results demonstrate the potential use of Y. lipolytica as a promising microbial cell factory for trans-10, cis-12-CLA production.

2013-01-01

353

The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium.  

PubMed

Conjugated linoleic acid (CLA), a family of isomers of octadecadienoic acid, inhibits rat mammary carcinogenesis, angiogenesis, and lung metastasis from a transplantable mammary tumor. c9,t11-CLA, the predominant isomer in dairy products, and t10,c12-CLA, a component of CLA supplements, are equally effective. The objective of the current studies was to test the efficacy of these two CLA isomers in a clinically relevant breast cancer model. Transgenic mice over-expressing erbB2 in the mammary epithelium were fed control or 0.5% CLA-supplemented diets continuously from weaning. Unexpectedly, t10,c12-CLA stimulated lobular hyperplasia of the mammary epithelium and accelerated mammary tumor development, decreasing median tumor latency to 168 days of age compared with 256 and 270 days in the c9,t11-CLA and control groups, respectively. Metastasis was also increased by t10,c12-CLA, with percentage of tumor-bearing mice with lung metastasis 73, 14 and 31% in the t10,c12-CLA, c9,t11-CLA and control groups, respectively. A second study, in which CLA administration was initiated after puberty, confirmed the stimulatory effect of t10,c12-CLA on mammary tumor development and metastasis. Additionally, t10,c12-CLA, but not c9,t11-CLA, increased the size of the liver, heart, spleen and mammary lymph node. The effects of t10,c12-CLA were not specific to erbB2 transgenic mice, as t10,c12-CLA supplementation increased proliferation in the mammary epithelium of both wild-type FVB and FVB/erbB2 mice. Moreover, the number of terminal end buds, the mammary epithelial structures most sensitive to a carcinogenic insult, was increased 30-fold in FVB wild-type mice fed t10,c12-CLA. These data suggest that it would be prudent to avoid CLA supplements containing the t10,c12-CLA isomer. However, even though c9,t11-CLA was not efficacious in the erbB2 model, its ability to inhibit mammary tumor development in rat models suggests that it may have activity for prevention of some types of breast cancer. PMID:17259656

Ip, Margot M; McGee, Sibel O; Masso-Welch, Patricia A; Ip, Clement; Meng, Xiaojing; Ou, Lihui; Shoemaker, Suzanne F

2007-06-01

354

The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice overexpressing erbB2 in the mammary epithelium  

PubMed Central

Conjugated linoleic acid (CLA), a family of isomers of octadecadienoic acid, inhibits rat mammary carcinogenesis, angiogenesis, and lung metastasis from a transplantable mammary tumor. c9,t11-CLA, the predominant isomer in dairy products, and t10,c12-CLA, a component of CLA supplements, are equally effective. The objective of the current studies was to test the efficacy of these two CLA isomers in a clinically relevant breast cancer model. Transgenic mice overexpressing erbB2 in the mammary epithelium were fed control or 0.5% CLA-supplemented diets continuously from weaning. Unexpectedly, t10,c12-CLA stimulated lobular hyperplasia of the mammary epithelium and accelerated mammary tumor development, decreasing median tumor latency to 168 days of age compared to 256 and 270 days in the c9,t11-CLA and control groups, respectively. Metastasis was also increased by t10,c12-CLA, with percent of tumor-bearing mice with lung metastasis 73%, 14%, and 31%, in the t10,c12-CLA, c9,t11-CLA and control groups, respectively. A second study, in which CLA administration was initiated after puberty, confirmed the stimulatory effect of t10,c12-CLA on mammary tumor development and metastasis. Additionally, t10,c12-CLA, but not c9,t11-CLA, increased the size of the liver, heart, spleen and mammary lymph node. The effects of t10,c12-CLA were not specific to erbB2 transgenic mice, as t10,c12-CLA supplementation increased proliferation in the mammary epithelium of both wild type FVB and FVB/erbB2 mice. Moreover, the number of terminal end buds, the mammary epithelial structures most sensitive to a carcinogenic insult, was increased 30-fold in FVB/wild type mice fed t10,c12-CLA. These data suggest that it would be prudent to avoid CLA supplements containing the t10,c12-CLA isomer. However, even though c9,t11-CLA was not efficacious in the erbB2 model, its ability to inhibit mammary tumor development in rat models suggests that it may have activity for prevention of some types of breast cancer.

Ip, Margot M.; McGee, Sibel O.; Masso-Welch, Patricia A.; Ip, Clement; Meng, Xiaojing; Ou, Lihui; Shoemaker, Suzanne

2009-01-01

355

Giant magnetoelectric coefficients in (Fe90Co10)78Si12B10-AlN thin film composites  

NASA Astrophysics Data System (ADS)

Thin film magnetoelectric (ME) two-two composites consisting of AlN and amorphous (Fe90Co10)78Si12B10 layers were fabricated by magnetron sputtering on Si (100) substrates. Upon magnetic field annealing they show an extremely high ME coefficient of 737 V/cm Oe at mechanical resonance at 753 Hz and 3.1 V/cm Oe out of resonance at 100 Hz. These are the highest reported ME coefficients in thin film composites ever. Furthermore, the induced magnetic anisotropy by field annealing serves the possibility to obtain a sensor element with a pronounced sensitivity in only one dimension, which allows the realization of a three-dimensional vector field sensor.

Greve, Henry; Woltermann, Eric; Quenzer, Hans-Joachim; Wagner, Bernhard; Quandt, Eckhard

2010-05-01

356

38 CFR 58.11 - VA Form 10-5588-State Home Report and Statement of Federal Aid Claimed.  

Code of Federal Regulations, 2011 CFR

38 Ç Pensions, Bonuses, and Veterans' Relief Ç 2 Ç 2013-07-01 Ç 2013-07-01 Ç false Ç VA Form 10-5588-State Home Report and Statement of Federal Aid Claimed. Ç 58.11 Ç Section 58.11 Ç Pensions, Bonuses, and Veterans' Relief Ç DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) Ç FORMS Ç Â§ 58.11 Ç VA...

2013-07-01

357

Dog erythrocyte antigens 1.1, 1.2, 3, 4, 7, and Dal blood typing and cross-matching by gel column technique  

PubMed Central

Background Testing for canine blood types other than dog erythrocyte antigen 1.1 (DEA 1.1) is controversial and complicated by reagent availability and methodology. Objectives The objectives of this study were to use available gel column technology to develop an extended blood-typing method using polyclonal reagents for DEA 1.1, 1.2, 3, 4, 7, and Dal and to assess the use of gel columns for cross-matching. Methods Dogs (43–75) were typed for DEA 1.1, 1.2, 3, 4, 7, and Dal. Methods included tube agglutination (Tube) using polyclonal reagents, a commercially available DEA 1.1 gel column test kit (Standard-Gel) using monoclonal reagent, and multiple gel columns (Extended-Gel) using polyclonal reagents. Blood from 10 recipient and 15 donor dogs was typed as described above and cross-matched using the gel column technique. Results Of 43 dogs typed for DEA 1.1, 23, 25, and 20 dogs were positive using Standard-Gel, Extended-Gel, and Tube, respectively. Typing for DEA 1.2 was not achievable with Extended-Gel. For 75 dogs typed for DEA 3, 4, and 7, concordance of Extended-Gel with Tube was 94.7%, 100%, and 84%, respectively. Dal, determined only by Extended-Gel, was positive for all dogs. Post-transfusion major cross-matches were incompatible in 10 of 14 pairings, but none were associated with demonstrable blood type incompatibilities. Conclusions Gel column methodology can be adapted for use with polyclonal reagents for detecting DEA 1.1, 3, 4, 7, and Dal. Agglutination reactions are similar between Extended-Gel and Tube, but are more easily interpreted with Extended-Gel. When using gel columns for cross-matching, incompatible blood cross-matches can be detected following sensitization by transfusion, although in this study incompatibilities associated with any tested DEA or Dal antigens were not found.

Kessler, Rebecca J.; Reese, Jessica; Chang, Denise; Seth, Mayank; Hale, Anne S.; Giger, Urs

2011-01-01

358

Expression and characterization of recombinant GH11 xylanase from thermotolerant Streptomyces sp. SWU10.  

PubMed

Xylans are major hemicellulose components of plant cell wall which can be hydrolyzed by xylanolytic enzymes. Three forms of endo-?-1,4-xylanases (XynSW1, XynSW2A, and XynSW2B) produced by thermotolerant Streptomyces sp. SWU10 have been reported. In the present study, we described the expression and characterization of the fourth xylanase enzyme from this bacteria, termed XynSW3. The gene containing 726 bp was cloned and expressed in Escherichia coli. The recombinant enzyme (rXynSW3) was purified from cell-free extract to homogeneity using Ni-affinity column chromatography. The apparent molecular mass of rXynSW3 was 48 kDa. Amino acid sequence analysis revealed that it belonged to a xylanase of glycoside hydrolase family 11. The optimum pH and temperature for enzyme activity were 5.5-6.5 and 50 °C, respectively. The enzyme was stable up to 40 °C and in wide pH ranges (pH 0.6-10.3). Xylan without arabinosyl side chain is the most preferable substrate for the enzyme. By using birch wood xylan as substrate, rXynSW3 produced several oligosaccharides in the initial stage of hydrolysis, and their levels increased with time, demonstrating that the enzyme is an endo-acting enzyme. The major products were xylobiose, triose, and tetraose. The rXynSW3 can be applied in several industries such as food, textile, and biofuel industries, and waste treatment. PMID:24197520

Sukhumsirichart, Wasana; Deesukon, Warin; Kawakami, Takuya; Matsumoto, Shotaro; Seesom, Weeranuch; Sakamoto, Tatsuji

2014-01-01

359

Pioneer 10, 11 observations of evolving solar wind streams and shocks beyond 1 AU  

NASA Technical Reports Server (NTRS)

Observations between 1 and 5 AU by Pioneers 10 and 11 have led to the identification of large numbers of interplanetary shocks. Both forward and reverse shocks, which begin to develop beyond 1.5 AU and which frequently appear as shock pairs, are found to accompany solar wind streams. The number of forward shocks continues to increase out to at least 5 AU. Reverse shocks are seen less often than forward shocks and, in some instances, disappear at larger distances. There is evidence that the shocks are corotating in the solar frame, as anticipated theoretically. The evolution of solar wind streams beyond 1 AU is profoundly affected by the shocks. A thick interaction region, with large enhancements in density, temperature, field strength and fluctuation level, forms in the region originally characterized by a positive velocity gradient. The solar wind and magnetic field properties adjacent to, and within, the interaction regions have been studied to determine their qualitative behavior and characteristic changes with distance. Several interplanetary shocks generated by solar flares have also been identified and analyzed.

Smith, E. J.; Wolfe, J. H.

1977-01-01

360

Parenting styles, parenting practices, and physical activity in 10- to 11-year olds  

PubMed Central

Objective The objective of this study was to determine whether parenting styles and practices are associated with children's physical activity. Methods Cross-sectional survey of seven hundred ninety-two 10- to 11-year-old UK children in Bristol (UK) in 2008–2009 was conducted. Accelerometer-assessed physical activity and mean minutes of moderate-to-vigorous physical activity (mean MVPA) and mean counts per minute (mean CPM) were obtained. Maternal parenting style and physical activity parenting practices were self-reported. Results In regression analyses, permissive parenting was associated with higher mean MVPA among girls (+ 6.0 min/day, p < 0.001) and greater mean CPM (+ 98.9 accelerometer counts/min, p = 0.014) among boys when compared to children with authoritative parents. Maternal logistic support was associated with mean CPM for girls (+ 36.2 counts/min, p = 0.001), while paternal logistic support was associated with boys' mean MVPA (+ 4.0 min/day, p = 0.049) and mean CPM (+ 55.7 counts/min, p = 0.014). Conclusions Maternal permissive parenting was associated with higher levels of physical activity than authoritative parenting, but associations differed by child gender and type of physical activity. Maternal logistic support was associated with girls' physical activity, while paternal logistic support was associated with boys' physical activity. Health professionals could encourage parents to increase logistic support for their children's physical activity.

Jago, Russell; Davison, Kirsten K.; Brockman, Rowan; Page, Angie S.; Thompson, Janice L.; Fox, Kenneth R.

2011-01-01

361

Acaricidal activity of 9-oxo-10,11-dehydroageraphorone extracted from Eupatorium adenophorum in vitro.  

PubMed

The acaricidal activity of the 9-oxo-10,11-dehydroageraphorone (euptox A), a cadenine sesquiterpene from Eupatorium adenophorum (E. adenophorum) against Sarcoptes scabiei and Psoroptes cuniculi was tested in vitro. A complementary log-log (CLL) model was used to analyze the data of the toxicity tests in vitro. The results showed euptox A had strong toxicity against mites, killing all S. scabiei at 3 and 4 mg/ml (m/v) concentration, while 4 mg/ml euptox A was also found to kill all P. cuniculi within a 4 h period. Similarly, 2, 3 and 4 mg/ml concentration of euptox A had strong toxicity against S. scabiei, with median lethal time (LT50) values at 0.687, 0.526, 0.326 h, respectively. 3 mg/ml and 4 mg/ml showed strong acaricidal action against P. cuniculi; the LT50 values were 0.693 and 0.493 h, respectively. The median lethal concentration (LC50) values were 1.068 mg/ml for Scabies mite and 0.902 mg/ml for P. cuniculi in 2 h. The results indicate that euptox A has strong acaricidal activity and may exploit as novel drugs for the effective control of animal acariasis. PMID:24631419

Liao, Fei; Hu, Yanchun; Tan, Hui; Wu, Lei; Wang, Yunfei; Huang, Yue; Mo, Quan; Wei, Yahui

2014-05-01

362

t(6;11) Renal Cell Carcinoma (RCC): Expanded Immunohistochemical Profile Emphasizing Novel RCC Markers and Report of 10 New Genetically Confirmed Cases.  

PubMed

Renal cell carcinomas (RCCs) harboring the t(6;11)(p21;q12) translocation were first described in 2001 and recently recognized by the 2013 International Society of Urological Pathology Vancouver Classification of Renal Neoplasia. Although these RCCs are known to label for melanocytic markers HMB45 and Melan A and the cysteine protease cathepsin K by immunohistochemistry (IHC), a comprehensive IHC profile has not been reported. We report 10 new t(6;11) RCCs, all confirmed by break-apart TFEB fluorescence in situ hybridization. A tissue microarray containing 6 of these cases and 7 other previously reported t(6;11) RCCs was constructed and immunolabeled for 21 different antigens. Additional whole sections of t(6;11) RCC were labeled with selected IHC markers. t(6;11) RCC labeled diffusely and consistently for cathepsin K and Melan A (13 of 13 cases) and almost always at least focally for HMB45 (12 of 13 cases). They labeled frequently for PAX8 (14 of 23 cases), CD117 (10 of 14 cases), and vimentin (9 of 13 cases). A majority of cases labeled at least focally for cytokeratin Cam5.2 (8 of 13 cases) and CD10 and RCC marker antigen (10 of 14 cases each). In contrast to a prior study's findings, only a minority of cases labeled for Ksp-cadherin (3 of 19 cases). The median H score (product of intensity score and percentage labeling) for phosphorylated S6, a marker of mTOR pathway activation, was 101, which is high relative to most other RCC subtypes. In summary, IHC labeling for PAX8, Cam5.2, CD10, and RCC marker antigen supports classification of the t(6;11) RCC as carcinomas despite frequent negativity for broad-spectrum cytokeratins and EMA. Labeling for PAX8 distinguishes the t(6;11) RCC from epithelioid angiomyolipoma, which otherwise shares a similar immunoprofile. CD117 labeling is more frequent in the t(6;11) RCC compared with the related Xp11 translocation RCC. Increased pS6 expression suggests a possible molecular target for the uncommon t(6;11) RCCs that metastasize. PMID:24618616

Smith, Nathaniel E; Illei, Peter B; Allaf, Mohamed; Gonzalez, Nilda; Morris, Kerry; Hicks, Jessica; Demarzo, Angelo; Reuter, Victor E; Amin, Mahul B; Epstein, Jonathan I; Netto, George J; Argani, Pedram

2014-05-01

363

(12)CO (3-2) & (1-0) emission line observations of nearby starburst galaxy nuclei  

NASA Technical Reports Server (NTRS)

New measurements of the (12)CO (1-0) and (12)CO (3-2) line emission are presented for the nuclei of seven nearby starburst galaxies selected from a complete sample of 21 nearby starburst galaxies for which the nuclear star formation rates are measured to be comparable to the archetype starburst galaxies M82 and NGC 253. The new observations capitalize on the coincidence between the beam size of the 45 m Nobeyama telescope at 115 GHz and that of the 15 m James Clerk Maxwell Telescope at 345 GHz to measure the value of the (12)CO (3-2)/(1-0) emission line ratio in a 15 sec (less than or equal to 2.5 kpc) diameter region centered on the nuclear starburst. In principle, the (12)CO (3-2)/(1-0) emission line ratio provides a measure of temperature and optical depth for the (12)CO gas. The error weighted mean value of the (12)CO (3-2)/(1-0) emission line ratio measured for the seven starburst galaxy nuclei is -0.64 +/- 0.06. The (12)CO (3-2)/(1-0) emission line ratio measured for the starburst galaxy nuclei is significantly higher than the average value measured for molecular gas in the disk of the Galaxy, implying warmer temperatures for the molecular gas in starburst galaxy nuclei. On the other hand, the (12)CO (3-2)/(1-0) emission line ratio measured for the starburst galaxy nuclei is not as high as would be expected if the molecular gas were hot, greater than 20 K, and optically thin, tau much less than 1. The total mass of molecular gas contained within the central 1.2-2.8 kpc diameter region of the starburst galaxy nuclei ranges from 10(exp 8) to 10(exp 9) solar mass. While substantial, the molecular gas mass represents only a small percentage, approximately 9%-16%, of the dynamical mass in the same region.

Devereux, Nicholas; Taniguchi, Yoshiaki; Sanders, D. B.; Nakai, N.; Young, J. S.

1994-01-01

364

41 CFR 301-11.2 - Will I be reimbursed for per diem expenses if my official travel is 12 hours or less?  

Code of Federal Regulations, 2013 CFR

...expenses if my official travel is 12 hours or less? 301-11.2 Section 301-11.2 Public Contracts and Property Management Federal...TDY) TRAVEL ALLOWANCES ALLOWABLE TRAVEL EXPENSES 11-PER DIEM EXPENSES General Rules §...

2013-07-01

365

Mosaic Intrachromosomal Triplication of (12)(p11.2p13) in a Patient with Pallister-Killian Syndrome  

PubMed Central

Pallister-Killian syndrome (PKS) is a rare genetic disorder usually characterized by mosaic tetrasomy of isochromosome 12p detected in cultured fibroblast cells. We describe here a patient with PKS and intrachromosomal triplication of the short arm of chromosome 12. Her karyotype was mos 46,XX,inv trp(12)(p11.2p13)[34]/ 46,XX[16]de novo by conventional cytogenetics and fluorescent in situ hybridization (FISH) analysis. However, this chromosomal abnormality was not detected from the patient’s cultured blood lymphocytes. We report here the third patient with intrachromosomal triplication on the short arm of chromosome 12, presenting a PKS phenotype.

Yakut, S; Mihci, E; Altiok Clark, O; Cetin, Z; Keser, I; Berker, S; Luleci, G

2012-01-01

366

Secondary School Curriculum Guide. Music. Grades 10-12. Draft Copy.  

ERIC Educational Resources Information Center

This draft curriculum guide provides curriculum materials that are organized into behavioral objectives with a scope and sequence. Divided by grade and levels, each section includes level objectives and suggested activities. To be covered in grades 10-12 are 5 levels of musical content. They are: 1) why man creates and how he perceives; 2) the…

Rogers, Arnold R., Ed.; And Others

367

Alcohol and Drug Prevention Curriculum Resource Guide Grades 10-12: Science--Biology.  

ERIC Educational Resources Information Center

This curriculum resource guide on alcohol and drug prevention provides suggested activities for teachers of grades 10 through 12. Three integrated learning activities for science/biology and healthful living are presented. The science/biology goal is understanding the biology of humans. Healthful living goals include analyzing drug and alcohol use…

North Carolina State Dept. of Public Instruction, Raleigh. Alcohol and Drug Defense Program.

368

Alcohol and Drug Prevention Curriculum Resource Guide Grades 10-12: Communication Skills--English IV.  

ERIC Educational Resources Information Center

This curriculum resource guide on alcohol and drug prevention provides suggested activities for teachers of grades 10 through 12. Four integrated learning activities for communication skills/ English IV and healthful living are presented. Communication skills/literature goals include experiencing young adult literature, using effective techniques…

North Carolina State Dept. of Public Instruction, Raleigh. Alcohol and Drug Defense Program.

369

Eyewitness Identification Accuracy and Response Latency: The Unruly 10-12-Second Rule  

ERIC Educational Resources Information Center

Data are reported from 3,213 research eyewitnesses confirming that accurate eyewitness identifications from lineups are made faster than are inaccurate identifications. However, consistent with predictions from the recognition and search literatures, the authors did not find support for the "10-12-s rule" in which lineup identifications faster…

Weber, Nathan; Brewer, Neil; Wells, Gary L.; Semmler, Carolyn; Keast, Amber

2004-01-01

370

Fine Arts, Grades 3, 6, 8, 10, 12. State Goals for Learning and Sample Learning Objectives.  

ERIC Educational Resources Information Center

This document, developed by the Illinois State Boaord of Education, identifies five state goals for learning in the fine arts, and provides sample learning objectives for grades, 3, 6, 8, 10, 12, which are consistent with the goals. The state goals for learning are broadly stated expressions of what the Illinois State Board of Education expects…

Illinois State Board of Education, Springfield. Dept. of School Improvement Services.

371

Social Sciences, Grades 3, 6, 8, 10, 12. State Goals for Learning and Sample Learning Objectives.  

ERIC Educational Resources Information Center

This document, developed by the Illinois State Board of Education, identifies five goals for learning in the social sciences, and provides sample learning objectives for grades 3, 6, 8, 10, 12, which are consistent with these goals. The state goals for learning are broadly stated expressions of what the Illinois State Board of Education wants and…

Illinois State Board of Education, Springfield. Dept. of School Improvement Services.

372

ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae.  

PubMed

The eukaryotic plasma membrane exhibits both asymmetric distribution of lipids between the inner and the outer leaflet and lateral segregation of membrane components within the plane of the bilayer. In budding yeast (Saccharomyces cerevisiae), maintenance of leaflet asymmetry requires P-type ATPases, which are proposed to act as inward-directed lipid translocases (Dnf1, Dnf2, and the associated protein Lem3), and ATP-binding cassette (ABC) transporters, which are proposed to act as outward-directed lipid translocases (Pdr5 and Yor1). The S. cerevisiae genome encodes two other Pdr5-related ABC transporters: Pdr10 (67% identity) and Pdr15 (75% identity). We report the first analysis of Pdr10 localization and function. A Pdr10-GFP chimera was located in discrete puncta in the plasma membrane and was found in the detergent-resistant membrane fraction. Compared to control cells, a pdr10 mutant was resistant to sorbate but hypersensitive to the chitin-binding agent Calcofluor White. Calcofluor sensitivity was attributable to a partial defect in endocytosis of the chitin synthase Chs3, while sorbate resistance was attributable to accumulation of a higher than normal level of the sorbate exporter Pdr12. Epistasis analysis indicated that Pdr10 function requires Pdr5, Pdr12, Lem3, and mature sphingolipids. Strikingly, Pdr12 was shifted to the detergent-resistant membrane fraction in pdr10 cells. Pdr10 therefore acts as a negative regulator for incorporation of Pdr12 into detergent-resistant membranes, a novel role for members of the ABC transporter superfamily. PMID:19452121

Rockwell, Nathan C; Wolfger, Hubert; Kuchler, Karl; Thorner, Jeremy

2009-05-01

373

Nationwide Surveillance of Influenza during the Pandemic (2009-10) and Post-Pandemic (2010-11) Periods in Taiwan  

PubMed Central

Introduction Although WHO declared the world moving into the post-pandemic period on August 10, 2010, influenza A(H1N1) 2009 virus continued to circulate globally. Its impact was expected to continue during the 2010–11 influenza season. This study describes the nationwide surveillance findings of the pandemic and post-pandemic influenza periods in Taiwan and assesses the impact of influenza A(H1N1) 2009 during the post-pandemic period. Methods The Influenza Laboratory Surveillance Network consisted of 12 contract laboratories for collecting and testing samples with acute respiratory tract infections. Surveillance of emergency room visits and outpatient department visits for influenza-like illness (ILI) were conducted using the Real-Time Outbreak and Disease Surveillance system and the National Health Insurance program data, respectively. Hospitalized cases with severe complications and deaths were reported to the National Notifiable Disease Surveillance System. Results During the 2009–10 influenza season, pandemic A(H1N1) 2009 was the predominant circulating strain and caused 44 deaths. However, the 2010–11 influenza season began with A(H3N2) being the predominant circulating strain, changing to A(H1N1) 2009 in December 2010. Emergency room and outpatient department ILI surveillance displayed similar trends. By March 31, 2011, there were 1,751 cases of influenza with severe complications; 50.1% reported underlying diseases. Of the reported cases, 128 deaths were associated with influenza. Among these, 93 (72.6%) were influenza A(H1N1) 2009 and 30 (23.4%) A(H3N2). Compared to the pandemic period, during the immediate post-pandemic period, increased number of hospitalizations and deaths were observed, and the patients were consistently older. Conclusions Reemergence of influenza A(H1N1) 2009 during the 2010–11 influenza season had an intense activity with age distribution shift. To further mitigate the impact of future influenza epidemics, Taiwan must continue its multifaceted influenza surveillance systems, remain flexible with antiviral use policies, and revise the vaccine policies to include the population most at risk.

Chuang, Jen-Hsiang; Huang, Angela S.; Huang, Wan-Ting; Liu, Ming-Tsan; Chou, Jih-Haw; Chang, Feng-Yee; Chiu, Wen-Ta

2012-01-01

374

Direct absorption transitions to highly excited polyads 8, 10, and 12 of methane  

SciTech Connect

We report on the experimental observation of high-resolution rotationally resolved spectra of vibrational polyads 10 and 12 of methane lying approximately halfway to the dissociation energy. The spectra were obtained at 295 K and 124 K and pressures as low as 200 mbar using a highly sensitive laser-induced grating (LIG) technique. The spectra correspond to direct single-photon absorption transitions from the ground state with cross sections as low as 10{sup -25} to 10{sup -26} cm{sup 2} molecule{sup -1}. We discuss theoretical developments toward the complete analysis of these transitions.

Sadovskii, D. A. [Departement de physique, Universite du Littoral Cote d'Opale, F-59140 Dunkerque (France); Kozlov, D. N. [A. M. Prokhorov General Physics Institute, Russian Academy of Sciences, 38 Vavilov St., 119991 Moscow (Russian Federation); Departement de physique, Universite du Littoral Cote d'Opale, F-59140 Dunkerque (France); Radi, P. P. [Department of General Energy, Paul Scherrer Institute, CH-5232 Villigen PSI (Switzerland)

2010-07-15

375

Effect of Duration of Breastfeeding on Neuropsychological Development at 10 to 12 Years of Age in a Cohort of Healthy Children  

ERIC Educational Resources Information Center

Aim: The aim of this article was to explore the effect of duration of breastfeeding on neurocognitive development. Method: The long-term effect of breastfeeding on neurodevelopment was examined through a battery of neuropsychological tests in 1403 children (693 females, 710 males; mean age 11y 9mo [SD 6mo], range: 10y 3mo-12y 8mo) who were…

Tozzi, Alberto Eugenio; Bisiacchi, Patrizia; Tarantino, Vincenza; Chiarotti, Flavia; D'elia, Lidia; De Mei, Barbara; Romano, Mariateresa; Gesualdo, Francesco; Salmaso, Stefania

2012-01-01

376

Debris Avalanche at Forest Falls, San Bernardino County, California, July 11, 1999. Version 1.0.  

National Technical Information Service (NTIS)

The community of Forest Falls, California, is frequently subject to relatively slow moving debris flows. Some 11 debris flow events that were destructive to property have been recorded between 1955 and 1998. On July 11 and 13, 1999, debris flows again occ...

D. M. Morton R. M. Hauser

2001-01-01

377

Experimental study of bound states in 12Be through low-energy 11Be(d,p)-transfer reactions  

NASA Astrophysics Data System (ADS)

The bound states of 12Be have been studied through a 11Be(d,p)12Be transfer reaction experiment in inverse kinematics. A 2.8 MeV/u beam of 11Be was produced using the REX-ISOLDE facility at CERN. The outgoing protons were detected with the T-REX silicon detector array. The MINIBALL germanium array was used to detect gamma rays from the excited states in 12Be. The gamma-ray detection enabled a clear identification of the four known bound states in 12Be, and each of the states has been studied individually. Differential cross sections over a large angular range have been extracted. Spectroscopic factors for each of the states have been determined from distorted wave Born approximation (DWBA) calculations and have been compared to previous experimental and theoretical results.

Johansen, J. G.; Bildstein, V.; Borge, M. J. G.; Cubero, M.; Diriken, J.; Elseviers, J.; Fraile, L. M.; Fynbo, H. O. U.; Gaffney, L. P.; Gernhäuser, R.; Jonson, B.; Koldste, G. T.; Konki, J.; Kröll, T.; Krücken, R.; Mücher, D.; Nilsson, T.; Nowak, K.; Pakarinen, J.; Pesudo, V.; Raabe, R.; Riisager, K.; Seidlitz, M.; Tengblad, O.; Törnqvist, H.; Voulot, D.; Warr, N.; Wenander, F.; Wimmer, K.; De Witte, H.

2013-10-01

378

Radial alignment simulation of solar wind streams observed by Pioneers 10 and 11 in 1974  

NASA Technical Reports Server (NTRS)

A particularly favorable radial lineup between spacecraft in Earth orbit and Pioneers 10 and 11 (near the ecliptic plane at approximately 5.5 AU and approximately 4.5 AU, respectively) occurred in mid-1974, when the solar corona was in a stable and well-defined warped-dipole configuration. The radial alignment study reported here differs from previous applications of the technique in two respects: (1) It is the first time a two-dimensional (2-D) MHD model has been tested over such a lengthy propagation interval; the 2-D capability is crucial for treatment of the nonradial shearing motions occurring across the stream interface. (2) The three-dimensional (3-D) structure observed in the white light corona at that time is related to the systematic patterns of nonradial flow deflections appearing at the Pioneer corotating interaction region (CIR) fronts. Comparison of predicted and observed flows for pairs of streams in two successive rotations reveals that when the parent coronal hole projects far across the solar equator in a predominantly north-south orientation (i.e., nearest the 2-D idealization), the mapping is accurate down to details of the flow structures. But where the spacecraft tracks along a latitudinal boundary of a hole or the associated stream front is inclined at a shallow angle to the equator, the numerical projections deviate systematically from the observations. Among the sources of error are 3-D dynamical interactions neglected in the model, differential rotation effects, and slow temporal evolution of the coronal structures. A characteristic pattern of north-south and east-west deflections indicative of the 3-D geometry appears across the CIRs, but these patterns evidently reflect primarily the local, as opposed to global, orientation of the 3-D stream fronts. Such patterns appear common in CIRs observed by Pioneer during this period. These findings thus hold special relevance for the analysis of Ulysses observations, since the present coronal configuration is similar to that of 1974.

Pizzo, V. J.; Intriligator, D. S.; Siscoe, G. L.

1995-01-01

379

Objectively assessed physical activity and weight status in Maltese 11-12 year-olds.  

PubMed

The objectives of the study were to identify levels of physical activity and sedentary time and assess how they differ by weight status in Maltese boys and girls. Participants were 234 Maltese children aged 11-12 years, of which 187 (80%) provided complete data. Physical activity was assessed using accelerometry and weight status determined through gender-specific age-adjusted Body mass index (BMI). Self-reported mode of transport to school, TV and computer time, gaming and mobile phone use were assessed by questionnaire. Total physical activity was generally very low and significantly lower for girls than boys at all times on weekdays and on weekends till 7 pm. Overweight and obesity prevalence was 27% and 18.6%, respectively. Differences in overall physical activity were observed between non-overweight, and overweight and obese boys (p=0.003). Differences in moderate to vigorous intensity physical activity (MVPA) in boys were significant across all weight categories (p=0.001) and in girls (p=0.020) between the overweight (27.6 min), the non-overweight (26.4 min) and the obese (18.9 min). For weekdays, mean physical activity differences (p=0.013) were observed between non-overweight (515.5 cpm) and obese boys (416.4 cpm). Differences in MVPA were found (p=0.038) between non-overweight (4.4 min) and obese boys in the 6 am-3 pm period. Differences were also found between overweight (13.2 min) and obese girls (8.1 min) (p=0.024) in that period. On weekends, mean physical activity differences were found between non-overweight and overweight boys from 8 am-7 pm but not for girls. Physical activity levels in this sample were very low when compared to recommended levels, while the prevalence of overweight and obesity and sedentary time were high. Girls are significantly less active than boys throughout the week. Activity level differences and patterning across the day and week were related to weight status with obese children showing markedly less activity. These results suggest that we need to provide more opportunities for overweight and obese children to be active throughout the week, with a particular emphasis on physical activity during school hours. PMID:24444216

Decelis, Andrew; Jago, Russell; Fox, Kenneth R

2014-01-01

380

Kootenay Lake Fertilization Experiment; Years 11 and 12, Technical Report 2002-2003.  

SciTech Connect

This report examines the results from the eleventh and twelfth years (2002 and 2003) of the Kootenay Lake fertilization experiment. Experimental fertilization has occurred with an adaptive management approach since 1992 in order to restore productivity lost as a result of upstream dams. One of the main objectives of the experiment is to restore kokanee (Oncorhynchus nerka) populations, which are a main food source for Gerrard rainbow trout (Oncorhynchus mykiss). Kootenay Lake is located between the Selkirk and Purcell mountains in southeastern British Columbia. It has an area of 395 km2, a maximum depth of 150 m, a mean depth of 94 m, and a water renewal time of approximately two years. The quantity of agricultural grade liquid fertilizer (10-34-0, ammonium polyphosphate and 28-0-0, urea ammonium nitrate) added to Kootenay Lake in 2002 and 2003 was similar to that added from 1992 to 1996. After four years of decreased fertilizer loading (1997 to 2000), results indicated that kokanee populations had declined, and the decision was made to increase the loads again in 2001. The total load of fertilizer in 2002 was 47.1 tonnes of phosphorus and 206.7 tonnes of nitrogen. The total fertilizer load in 2003 was 47.1 tonnes of phosphorus and 240.8 tonnes of nitrogen. Additional nitrogen was added in 2003 to compensate for nitrogen depletion in the epilimnion. The fertilizer was applied to a 10 km stretch in the North Arm from 3 km south of Lardeau to 3 km south of Schroeder Creek. The maximum surface water temperature in 2002, measured on July 22, was 22 C in the North Arm and 21.3 C in the South Arm. In 2003, the maxima were recorded on August 5 at 20.6 C in the North Arm and on September 2 at 19.7 C in the South Arm. The maximum water temperature in the West Arm was 18.7 C on September 2, 2003. Kootenay Lake had oxygen-saturated water throughout the sampling season with values ranging from about 11-16 mg/L in 2002 and 2003. In both years, Secchi depth followed the expected pattern for an oligo-mesotrophic lake of decreasing in May, June, and early July, concurrent with the spring phytoplankton bloom, and clearing again as the summer progressed. Total phosphorus (TP) ranged from 2-11 {micro}g/L in 2002 and 2-21 {micro}g/L in 2003. With average TP values generally in the range of 3-10 {micro}g/L, Kootenay Lake is considered to be an oligotrophic to oligo-mesotrophic lake. Total dissolved phosphorus (TDP) followed the same seasonal trends as TP in 2002 and 2003 and ranged from 2-7 {micro}g/L in 2002 and from 2-10 {micro}g/L in 2003. Total nitrogen (TN) ranged from 90-380 {micro}g/L in 2002 and 100-210 {micro}g/L in 2003. During both the 2002 and 2003 sampling seasons, TN showed an overall decline in concentration with mid-summer and fall increases at some stations, which is consistent with previous years results. Dissolved inorganic nitrogen (DIN) concentrations showed a more pronounced declining trend over the sampling season compared with TN, corresponding to nitrate (the dominant component of DIN) being used by phytoplankton during summer stratification. DIN ranged from 7-176 {micro}g/L in 2002 and from 8-147 {micro}g/L in 2003. During 2003, discrete depth sampling occurred, and a more detailed look at the nitrate concentrations in the epilimnion was undertaken. There was a seasonal decline in nitrate concentrations, which supports the principle of increasing the nitrogen loading and the nitrogen to phosphorus (N:P) ratio during the fertilizer application period. Chlorophyll a (Chl a) concentrations in Kootenay Lake were in the range of 1.4-5.1 {micro}g/L in 2002 and 0.5-4.9 {micro}g/L in 2003. Over the sampling season, Chl a at North Arm stations generally increased in spring corresponding with the phytoplankton bloom, decreased during the summer, and increased again in the fall with mixing of the water column. The trend was similar, but less pronounced, at South Arm stations in these years, and spring Chl a concentrations were lower. During 2002, total algal biomass averaged during June, July and August was lower in the North

Schindler, E.

2007-02-01

381

32 CFR 655.10 - Army entities on Army land (AR 385-11).  

Code of Federal Regulations, 2010 CFR

...ENVIRONMENTAL QUALITY] [Part 655 - RADIATION SOURCES ON ARMY LAND] [Sec. 655.10 Use of Radiation Sources by Non - Army entities on Army...true 655.10 Sec. 655.10 Use of radiation sources by non NATIONAL DEFENSE...

2003-01-01

382

32 CFR 655.10 - Army entities on Army land (AR 385-11).  

Code of Federal Regulations, 2010 CFR

...ENVIRONMENTAL QUALITY] [Part 655 - RADIATION SOURCES ON ARMY LAND] [Sec. 655.10 Use of Radiation Sources by Non - Army entities on Army...true 655.10 Sec. 655.10 Use of radiation sources by non NATIONAL DEFENSE...

2004-01-01

383

32 CFR 655.10 - Army entities on Army land (AR 385-11).  

Code of Federal Regulations, 2010 CFR

...ENVIRONMENTAL QUALITY] [Part 655 - RADIATION SOURCES ON ARMY LAND] [Sec. 655.10 Use of Radiation Sources by Non - Army entities on Army...false 655.10 Sec. 655.10 Use of radiation sources by non NATIONAL DEFENSE...

2002-07-01

384

Evidence, from Pioneer 10/11, Galileo, and Ulysses Data, for an Anomalous, Weak, Long-Range Acceleration  

NASA Technical Reports Server (NTRS)

Radio metric data from the Pioneer 10/11, Galileo, and Ulysses Spacecraft indicate an apparent anomalous, constant, acceleration acting on the spacecraft with a magnitude 8.5 x 10(sup -8) cm/s(sup 2), directed towards the Sun.

Anderson, J. D.; Laing, P. A.; Lau, E. L.; Liu, A. S.; Nieto, M. M.; Turyshev, S. G.

1998-01-01

385

Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels.  

PubMed

L-type Ca(2+) channels (LTCCs) play a critical role in Ca(2+)-dependent signaling processes in a variety of cell types. The number of functional LTCCs at the plasma membrane strongly influences the strength and duration of Ca(2+) signals. Recent studies demonstrated that endosomal trafficking provides a mechanism for dynamic changes in LTCC surface membrane density. The purpose of the current study was to determine whether the small GTPase Rab11b, a known regulator of endosomal recycling, impacts plasmalemmal expression of Ca(v)1.2 LTCCs. Disruption of endogenous Rab11b function with a dominant negative Rab11b S25N mutant led to a significant 64% increase in peak L-type Ba(2+) current (I(Ba,L)) in human embryonic kidney (HEK)293 cells. Short-hairpin RNA (shRNA)-mediated knockdown of Rab11b also significantly increased peak I(Ba,L) by 66% compared when with cells transfected with control shRNA, whereas knockdown of Rab11a did not impact I(Ba,L). Rab11b S25N led to a 1.7-fold increase in plasma membrane density of hemagglutinin epitope-tagged Ca(v)1.2 expressed in HEK293 cells. Cell surface biotinylation experiments demonstrated that Rab11b S25N does not significantly impact anterograde trafficking of LTCCs to the surface membrane but rather slows degradation of plasmalemmal Ca(v)1.2 channels. We further demonstrated Rab11b expression in ventricular myocardium and showed that Rab11b S25N significantly increases peak I(Ba,L) by 98% in neonatal mouse cardiac myocytes. These findings reveal a novel role for Rab11b in limiting, rather than promoting, the plasma membrane expression of Ca(v)1.2 LTCCs in contrast to its effects on other ion channels including human ether-a-go-go-related gene (hERG) K(+) channels and cystic fibrosis transmembrane conductance regulator. This suggests Rab11b differentially regulates the trafficking of distinct cargo and extends our understanding of how endosomal transport impacts the functional expression of LTCCs. PMID:21248079

Best, Jabe M; Foell, Jason D; Buss, Courtney R; Delisle, Brian P; Balijepalli, Ravi C; January, Craig T; Kamp, Timothy J

2011-05-01

386

12 CFR 704.11 - Corporate Credit Union Service Organizations (Corporate CUSOs).  

...2014-01-01 2014-01-01 false Corporate Credit Union Service Organizations (Corporate CUSOs...Section 704.11 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS CORPORATE CREDIT UNIONS §...

2014-01-01

387

12 CFR 707.11 - Additional disclosure requirements for credit unions advertising the payment of overdrafts.  

Code of Federal Regulations, 2010 CFR

...REGULATIONS AFFECTING CREDIT UNIONS TRUTH IN SAVINGS § 707.11 ...such as a telephone response machine, an automated teller machine (ATM), or a credit union's...such as a telephone response machine, ATM, or a credit...

2009-01-01

388

12 CFR 707.11 - Additional disclosure requirements for overdraft services.  

Code of Federal Regulations, 2010 CFR

...REGULATIONS AFFECTING CREDIT UNIONS TRUTH IN SAVINGS § 707.11 ...such as a telephone response machine, ATM, or a credit union's...screens and telephone response machines. The disclosures described...using a telephone response machine. (4) Exception for...

2010-01-01

389

12 CFR 723.11 - How do you obtain a waiver?  

Code of Federal Regulations, 2010 CFR

...CREDIT UNIONS MEMBER BUSINESS LOANS § 723.11 ...(a) A copy of your business lending policy; (b...activity; and (e) An analysis of the credit union's...experience making member business loans, including as...

2010-01-01

390

12 CFR 723.11 - How do you obtain a waiver?  

...CREDIT UNIONS MEMBER BUSINESS LOANS § 723.11 ...(a) A copy of your business lending policy; (b...activity; and (e) An analysis of the credit union's...experience making member business loans, including as...

2014-01-01

391

12 CFR 723.11 - How do you obtain a waiver?  

Code of Federal Regulations, 2011 CFR

...CREDIT UNIONS MEMBER BUSINESS LOANS § 723.11 ...(a) A copy of your business lending policy; (b...activity; and (e) An analysis of the credit union's...experience making member business loans, including as...

2011-01-01

392

12 CFR 723.11 - How do you obtain a waiver?  

Code of Federal Regulations, 2013 CFR

...CREDIT UNIONS MEMBER BUSINESS LOANS § 723.11 ...(a) A copy of your business lending policy; (b...activity; and (e) An analysis of the credit union's...experience making member business loans, including as...

2013-01-01

393

12 CFR 723.11 - How do you obtain a waiver?  

Code of Federal Regulations, 2012 CFR

...CREDIT UNIONS MEMBER BUSINESS LOANS § 723.11 ...(a) A copy of your business lending policy; (b...activity; and (e) An analysis of the credit union's...experience making member business loans, including as...

2012-01-01

394

High-Speed Cascade Tests of the NACA 65-(12A(sub 10))10 and NACA 65-(12A(sub 2)I(sub 8b))10 Compressor Blade Sections  

NASA Technical Reports Server (NTRS)

Two-dimensional porous-well cascade tests of the NACA 65- (l2Al0) 10 and NACA 65-(l2A2I8b)10 blade sections were made at Mach numbers from 0.3 to choking in most cases. Data were obtained at solidities of 1.0 and 1.5 et inlet-air angles of 45 deg. and 60 deg. for both blade sections. With a solid--wall modification to the cascade tunnel, schlieren observations were made of the flow in cascade at a solidity of 1.5 and inlet-air angle of 45 deg. and at a solidity of 1.0 and inlet-air angle of 60 deg. Test results for the NACA 65-(12A10)l0 blade section show t hat the turning angles measured at low speed do not change significantly as the speed increases until the critical Mach number is exceed. Because of increasing separation from the highly cambered trailing-edge region, the turning angles for the NACA 65-(12A2I8b)10 blade section decreased as much as 4 deg. from low speed to critical speed. The high-speed performance of the NACA 65-(12A10)10 and the NACA 65-(12A2I8b)l0 blade sections is largely determined by the passage area distribution. The angle of attack for best operation at high Mach numbers is higher than the design angle of attack selected at low speed to have pressure distributions that are free of peaks.

Dunavant, James C.; Emery, James C.; Walch, Howard C.; Westphal, Willard R.

1955-01-01

395

The biological actions of 11,12-epoxyeicosatrienoic Acid in endothelial cells are specific to the r/s-enantiomer and require the gs protein.  

PubMed

Cytochrome P450-derived epoxides of arachidonic acid [i.e., the epoxyeicosatrienoic acids (EETs)] are important lipid signaling molecules involved in the regulation of vascular tone and angiogenesis. Because many actions of 11,12-cis-epoxyeicosatrienoic acid (EET) are dependent on the activation of protein kinase A (PKA), the existence of a cell-surface Gs-coupled receptor has been postulated. To assess whether the responses of endothelial cells to 11,12-EET are enantiomer specific and linked to a potential G protein-coupled receptor, we assessed 11,12-EET-induced, PKA-dependent translocation of transient receptor potential (TRP) C6 channels, as well as angiogenesis. In primary cultures of human endothelial cells, (±)-11,12-EET led to the rapid (30 seconds) translocation a TRPC6-V5 fusion protein, an effect reproduced by 11(R),12(S)-EET, but not by 11(S),12(R)-EET or (±)-14,15-EET. Similarly, endothelial cell migration and tube formation were stimulated by (±)-11,12-EET and 11(R),12(S)-EET, whereas 11(S),12(R)-EET and 11,12-dihydroxyeicosatrienoic acid were without effect. The effects of (±)-11,12-EET on TRP channel translocation and angiogenesis were sensitive to EET antagonists, and TRP channel trafficking was also prevented by a PKA inhibitor. The small interfering RNA-mediated downregulation of Gs in endothelial cells had no significant effect on responses stimulated by vascular endothelial growth or a PKA activator but abolished responses to (±)-11,12-EET. The downregulation of Gq/11 failed to prevent 11,12-EET-induced TRPC6 channel translocation or the formation of capillary-like structures. Taken together, our results suggest that a Gs-coupled receptor in the endothelial cell membrane responds to 11(R),12(S)-EET and mediates the PKA-dependent translocation and activation of TRPC6 channels, as well as angiogenesis. PMID:24763066

Ding, Yindi; Frömel, Timo; Popp, Rüdiger; Falck, John R; Schunck, Wolf-Hagen; Fleming, Ingrid

2014-07-01

396

10 CFR 1046.11 - Medical and physical fitness qualification standards.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 false Medical and physical fitness qualification standards. ...§ 1046.11 Medical and physical fitness qualification standards. ...meet the applicable medical and physical fitness qualification standards as...

2010-01-01

397

10 CFR 1046.11 - Medical and physical fitness qualification standards.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 false Medical and physical fitness qualification standards. ...§ 1046.11 Medical and physical fitness qualification standards. ...meet the applicable medical and physical fitness qualification standards as...

2009-01-01

398

10 CFR 1706.11 - Organizational conflicts of interest certificate-Advisory or assistance services.  

Code of Federal Regulations, 2010 CFR

...INTERESTS § 1706.11 Organizational conflicts of interest certificate...Board solicitations: Organizational and Consultant Conflicts...Oct. 1990) (a) An organizational or consultant conflict...to the best of his or her knowledge and belief, no...

2010-01-01

399

10 CFR 1706.11 - Organizational conflicts of interest certificate-Advisory or assistance services.  

Code of Federal Regulations, 2010 CFR

...INTERESTS § 1706.11 Organizational conflicts of interest certificate...Board solicitations: Organizational and Consultant Conflicts...Oct. 1990) (a) An organizational or consultant conflict...to the best of his or her knowledge and belief, no...

2009-01-01

400

10 CFR 1046.11 - Medical and physical fitness qualification standards.  

... 2014-01-01 false Medical and physical fitness qualification standards. 1046...DEPARTMENT OF ENERGY (GENERAL PROVISIONS) PHYSICAL PROTECTION OF SECURITY INTERESTS (Eff...Personnel § 1046.11 Medical and physical fitness qualification...

2014-01-01

401

10 CFR 1046.11 - Medical and physical fitness qualification standards.  

Code of Federal Regulations, 2012 CFR

... 2012-01-01 false Medical and physical fitness qualification standards. 1046...DEPARTMENT OF ENERGY (GENERAL PROVISIONS) PHYSICAL PROTECTION OF SECURITY INTERESTS Protective...Personnel § 1046.11 Medical and physical fitness qualification...

2012-01-01

402

10 CFR 1046.11 - Medical and physical fitness qualification standards.  

Code of Federal Regulations, 2011 CFR

... 2011-01-01 false Medical and physical fitness qualification standards. 1046...DEPARTMENT OF ENERGY (GENERAL PROVISIONS) PHYSICAL PROTECTION OF SECURITY INTERESTS Protective...Personnel § 1046.11 Medical and physical fitness qualification...

2011-01-01

403

10 CFR 1046.11 - Medical and physical fitness qualification standards.  

Code of Federal Regulations, 2013 CFR

... 2013-01-01 false Medical and physical fitness qualification standards. 1046...DEPARTMENT OF ENERGY (GENERAL PROVISIONS) PHYSICAL PROTECTION OF SECURITY INTERESTS Protective...Personnel § 1046.11 Medical and physical fitness qualification...

2013-01-01

404

10 CFR 11.16 - Cancellation of request for special nuclear material access authorization.  

Code of Federal Regulations, 2013 CFR

...FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...for Special Nuclear Material Access Authorization § 11.16 ...Determining Eligibility for Access to, or Control Over, Special Nuclear...

2014-01-01

405

Atmospheric correction of infrared measurements of sea surface temperature using channels at 3.7, 11 and 12 Mum  

Microsoft Academic Search

Atmospheric effects upon the radiometric determination of surface temperature were studied for channels centered at 3.7, 11 and 12 Mum. The error due to the atmosphere is least for the channel centered at 3.7 Mum, which is a real advantage. The use of a linear combination of two or all three of these channels allows one to eliminate most of

P. Y. Deschamps; T. Phulpin

1980-01-01

406

Anionic iron clusters as building blocks for the synthesis of higher nuclearity compounds containing 11- and 12-group elements  

Microsoft Academic Search

Anionic iron clusters have been widely used as building blocks for the formation of mixed metal clusters with 11- and 12- group elements. This review summarizes the results reported in this area, paying special attention to the structural features of the metal core of the species reported.

Montserrat Ferrer; Roser Reina; Oriol Rossell; Miquel Seco

1999-01-01

407

618-10 Burial Ground Trench Remediation and 618-10 and 618-11 Burial Ground Nonintrusive Characterization of Vertical Pipe Units Lessons Learned  

SciTech Connect

A “lessons learned” is a noteworthy practice or innovative approach that is captured and shared to promote repeat application, or an adverse work practice/experience that is captured and shared to avoid reoccurrence. This document provides the lessons learned identified by the 618-10 Burial Ground trench remediation and the 618-10 and 618-11 Burial Ground nonintrusive characterization of the vertical pipe units (VPUs).

Darby, J. W.

2012-06-28

408

BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis.  

PubMed

The molecular mechanisms by which bone morphogenetic proteins (BMPs) promote skeletal cell differentiation were investigated in the murine mesenchymal stem cell line C3H10T1/2. Both BMP-7 and BMP-2 induced C3H10T1/2 cells to undergo a sequential pattern of chondrogenic followed by osteogenic differentiation that was dependent on both the concentration and the continuous presence of BMP in the growth media. Differentiation was determined by the expression of chondrogenesis and osteogenesis associated matrix genes. Subsequent experiments using BMP-7 demonstrated that withdrawal of BMP from the growth media led to a complete loss of skeletal cell differentiation accompanied by adipogenic differentiation of these cells. Continuous treatment with BMP-7 increased the expression of Sox9, Msx 2, and c-fos during the periods of chondrogenic differentiation after which point their expression decreased. In contrast, Dlx 5 expression was induced by BMP-7 treatment and remained elevated throughout the time-course of skeletal cell differentiation. Runx2/Cbfa1 was not detected by ribonuclease protection assay (RPA) and did not appear to be induced by BMP-7. The sequential nature of differentiation of chondrocytic and osteoblastic cells and the necessity for continuous BMP treatment to maintain skeletal cell differentiation suggests that the maintenance of selective differentiation of the two skeletal cell lineages might be dependent on BMP-7-regulated expression of other morphogenetic factors. An examination of the expression of Wnt, transforming growth factor-beta (TGF-beta), and the hedgehog family of morphogens showed that Wnt 5b, Wnt 11, BMP-4, growth and differentiation factor-1 (GDF-1), Sonic hedgehog (Shh), and Indian hedgehog (Ihh) were endogenously expressed by C3H10T1/2 cells. Wnt 11, BMP-4, and GDF-1 expression were inhibited by BMP-7 treatment in a dose-dependent manner while Wnt 5b and Shh were selectively induced by BMP-7 during the period of chondrogenic differentiation. Ihh expression also showed induction by BMP-7 treatment, however, the period of maximal expression was during the later time-points, corresponding to osteogenic differentiation. An interesting phenomenon was that BMP-7 activity could be further enhanced twofold by growing the cells in a more nutrient-rich media. In summary, the murine mesenchymal stem cell line C3H10T1/2 was induced to follow an endochondral sequence of chondrogenic and osteogenic differentiation dependent on both dose and continual presence of BMP-7 and enhanced by a nutrient-rich media. Our preliminary results suggest that the induction of osteogenesis is dependent on the secondary regulation of factors that control osteogenesis through an autocrine mechanism. PMID:14635186

Shea, Colleen M; Edgar, Cory M; Einhorn, Thomas A; Gerstenfeld, Louis C

2003-12-15

409

11 CFR 100.12 - Identification (2 U.S.C. 431(13)).  

Code of Federal Regulations, 2011 CFR

...2014-01-01 false Identification (2 U.S.C. 431(13)). 100.12 Section 100...GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) General Definitions § 100.12 Identification (2 U.S.C. 431(13)). Identification...

2014-01-01

410

Probing the Statistical Decay and ?-clustering effects in 12C + 12C and 14N + 10B reactions  

NASA Astrophysics Data System (ADS)

An experimental campaign has been undertaken at Laboratori Nazionali di Legnaro (LNL INFN), Italy, in order to progress in our understanding of the statistical properties of light nuclei at excitation energies above particle emission threshold, by measuring exclusive data from fusion-evaporation reactions. On the experimental side, a first reaction: 12C+12C at 95 MeV beam energy has been measured, using the GARFIELD + Ring Counter (RCo) apparatuses. Fusion-evaporation events have been exclusively selected out of the entire data set. The comparison to a dedicated Hauser-Feshbach calculation allows us to give constraints on the nuclear level density at high excitation energy for light systems ranging from C up to Mg. Out-of-equilibrium a? emission has been evidenced and attributed both to an entrance channel effect (favoured by the cluster nature of reaction partners), and, in more dissipative events, to the persistence of cluster correlations well above the 24Mg threshold for 6 ?'s decay. In order to study the same 24Mg compound nucleus at similar excitation energy with respect to this first reaction a new measurement, 14N + 10B at 5.7 A.MeV, was performed at LNL laboratories with the same experimental setup. The comparison between the two systems would allow us to further constrain the level density of light nuclei in the mass-excitation energy range of interest. In this perspective, deviations from a statistical behaviour can be used as a tool to get information on nuclear clustering, both in the ground-state for projectile and target and in the hot source formed in the collision.

Morelli, L.; Baiocco, G.; D'Agostino, M.; Bruno, M.; Gulminelli, F.; Cinausero, M.; Degerlier, M.; Fabris, D.; Gramegna, F.; Marchi, T.; Barlini, S.; Bini, M.; Casini, G.; Gelli, N.; Lopez, A.; Pasquali, G.; Piantelli, S.; Valdrè, S.

2014-03-01

411

MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis.  

PubMed

The translocation t(10;11)(p13;q14) has been observed in acute lymphoblastic leukemia (ALL) as well as acute myeloid leukemia (AML). A recent study showed a MLL/AF10 fusion in all cases of AML with t(10;11) and various breakpoints on chromosome 11 ranging from q13 to q23. We recently cloned CALM (Clathrin Assembly Lymphoid Myeloid leukemia gene), the fusion partner of AF10 at 11q14 in the monocytic cell line U937. To further define the role of these genes in acute leukemias, 10 cases (9 AML and 1 ALL) with cytogenetically proven t(10;11)(p12-14;q13-21) and well-characterized morphology, immunophenotype, and clinical course were analyzed. Interphase fluorescence in situ hybridization (FISH) was performed with 2 YACs flanking the CALM region, a YAC contig of the MLL region, and a YAC spanning the AF10 breakpoint. Rearrangement of at least one of these genes was detected in all cases with balanced t(10;11). In 4 cases, including 3 AML with immature morphology (1 AML-M0 and 2 AML-M1) and 1 ALL, the signals of the CALM YACS were separated in interphase cells, indicating a translocation breakpoint within the CALM region. MLL was rearranged in 3 AML with myelomonocytic differentiation (2 AML-M2 and 1 AML-M5), including 1 secondary AML. In all 3 cases, a characteristic immunophenotype was identified (CD4+, CD13-, CD33+, CD65s+). AF-10 was involved in 5 of 6 evaluable cases, including 1 case without detectable CALM or MLL rearrangement. In 2 complex translocations, none of the three genes was rearranged. All cases had a remarkably poor prognosis, with a mean survival of 9.6 +/- 6.6 months. For the 7 AML cases that were uniformly treated according to the AMLCG86/92 protocols, disease-free and overall survival was significantly worse than for the overall study group (P = .03 and P = .01, respectively). We conclude that the t(10;11)(p13;q14) indicates CALM and MLL rearrangements in morphologically distinct subsets of acute leukemia and may be associated with a poor prognosis. PMID:9616163

Dreyling, M H; Schrader, K; Fonatsch, C; Schlegelberger, B; Haase, D; Schoch, C; Ludwig, W; Löffler, H; Büchner, T; Wörmann, B; Hiddemann, W; Bohlander, S K

1998-06-15

412

Membrane defects enhance the interaction of antimicrobial peptides, aurein 1.2 versus caerin 1.1.  

PubMed

The membrane interactions of the antimicrobial peptides aurein 1.2 and caerin 1.1 were observed by (31)P and (2)H solid-state NMR and circular dichroism spectroscopy. Both peptides were relatively unstructured in water. In the presence of dimyristoylphosphatidylcholine (DMPC) and mixed DMPC and dimyristoylphosphatidylglycerol (DMPG) vesicles, both peptides displayed a considerable increase in helical content with the shorter aurein peptide having a higher ?-helix content in both lipid systems. In fluid phase DMPC vesicles, the peptides displayed differential interactions: aurein 1.2 interacted primarily with the bilayer surface, while the longer caerin 1.1 was able to penetrate into the bilayer interior. Both peptides displayed a preferential interaction with the DMPG component in DMPC/DMPG bilayers, with aurein 1.2 limited to interaction with the surface and caerin 1.1 able to penetrate into the bilayer and promote formation of a mixture of lipid phases or domains. In gel phase DMPC vesicles, aurein 1.2 disrupted the bilayer apparently through a carpet mechanism, while no additional interaction was seen with caerin 1.1. Although a lamellar bilayer was retained with the mixed DMPC/DMPG vesicles below the phase transition, both caerin 1.1 and aurein 1.2 promoted disruption of the bilayer and formation of an isotropic phase. The peptide interaction was enhanced relative to the fluid phase and was likely driven by co-existence of membrane defects. This study thus demonstrates that the effects of the lipid phase and domains need to be considered when studying membrane interactions of antimicrobial peptides. PMID:23506683

Fernandez, David I; Sani, Marc-Antoine; Miles, Andrew J; Wallace, B A; Separovic, Frances

2013-08-01

413

Cleanup Verification Package for the 118-H-6:2, 105-H Reactor Ancillary Support Areas, Below-Grade Structures, and Underlying Soils; the 118-H-6:3, 105-H Reactor Fuel Storage Basin and Underlying Soils; The 118-H-6:3 Fuel Storage Basin Deep Zone Side Slope Soils; the 100-H-9, 100-H-10, and 100-H-13 French Drains; the 100-H-11 and 100-H-12 Expansion Box French Drains; and the 100-H-14 and 100-H-31 Surface Contamination Zones  

SciTech Connect

This cleanup verification package documents completion of removal actions for the 105-H Reactor Ancillary Support Areas, Below-Grade Structures, and Underlying Soils (subsite 118-H-6:2); 105-H Reactor Fuel Storage Basin and Underlying Soils (118-H-6:3); and Fuel Storage Basin Deep Zone Side Slope Soils. This CVP also documents remedial actions for the following seven additional waste sties: French Drain C (100-H-9), French Drain D (100-H-10), Expansion Box French Drain E (100-H-11), Expansion Box French Drain F (100-H-12), French Drain G (100-H-13), Surface Contamination Zone H (100-H-14), and the Polychlorinated Biphenyl Surface Contamination Zone (100-H-31).

M. J. Appel

2006-06-29

414

Family10 and Family11 xylanases differ in their capacity to enhance the bleachability of hardwood and softwood paper pulps  

Microsoft Academic Search

Enzyme-aided bleaching of softwood and hardwood kraft pulps by glycosyl hydrolase family-10 and -11 xylanases and a family-26\\u000a mannanase was investigated. The ability to release reducing sugar from pulp xylan and to enhance bleachability is not a characteristic\\u000a shared by all xylanases. Of the six enzymes tested, two xylanases belonging to family 11 were most effective at increasing\\u000a bleachability and

J. H. Clarke; J. E. Rixon; A. Ciruela; H. J. Gilbert; G. P. Hazlewood

1997-01-01

415

Effect of chronic antipsychotic treatment on striatal phosphodiesterase 10A levels: a [11C]MP-10 PET rodent imaging study with ex vivo confirmation  

PubMed Central

A number of phosphodiesterase 10A (PDE10) inhibitors are about to undergo clinical evaluation for their efficacy in treating schizophrenia. As phosphodiesterases are in the same signalling pathway as dopamine D2 receptors, it is possible that prior antipsychotic treatment could influence these enzyme systems in patients. Chronic, in contrast to acute, antipsychotic treatment has been reported to increase brain PDE10A levels in rodents. The aim of this study was to confirm these findings in a manner that can be translated to human imaging studies to understand its consequences. Positron emission tomography (PET) scanning was used to evaluate PDE10A enzyme availability, after chronic haloperidol administration, using a specific PDE10A ligand ([11C]MP-10). The binding of [11C]MP-10 in the striatum and the cerebellum was measured in rodents and a simplified reference tissue model (SRTM) with cerebellum as the reference region was used to determine the binding potential (BPND). In rats treated chronically with haloperidol (2?mg?kg?1 per day), there was no significant difference in PDE10A levels compared with the vehicle-treated group (BPND±s.d.: 3.57±0.64 versus 2.86±0.71). Following PET scans, ex vivo analysis of striatal brain tissue for PDE10A mRNA (Pde10a) and PDE10A enzyme activity showed no significant difference. Similarly, the PDE10A protein content determined by western blot analysis was similar between the two groups, contrary to an earlier finding. The results of the study indicate that prior exposure to antipsychotic medication in rodents does not alter PDE10A levels.

Natesan, S; Ashworth, S; Nielsen, J; Tang, S-P; Salinas, C; Kealey, S; Lauridsen, J B; Stensb?l, T B; Gunn, R N; Rabiner, E A; Kapur, S

2014-01-01

416

Germanate with three-dimensional 12 × 12 × 11-ring channels solved by X-ray powder diffraction with charge-flipping algorithm.  

PubMed

A new open-framework germanate, denoted as GeO-JU90, was prepared by the hydrothermal synthesis method using 1,5-bis(methylpyrrolidinium)pentane dihydroxide as the organic structure-directing agent (SDA). The structure of GeO-JU90 was determined from synchrotron X-ray powder diffraction (XRPD) data using the charge-flipping algorithm. It revealed a complicated framework structure containing 11 Ge atoms in the asymmetric unit. The framework is built of 7-connected Ge7 clusters and additional tetrahedral GeO3(OH) units forming a new three-dimensional interrupted framework with interesting 12 × 12 × 11-ring intersecting channels. The Ge K-edge extended X-ray absorption fine structure (EXAFS) analysis was performed to provide the local structural information around Ge atoms, giving rise to a first-shell contribution from about 4.2(2) O atoms at the average distance of 1.750(8) Å. The guest species in the channels were subsequently determined by the simulated annealing method from XRPD data combining with other characterization techniques, e.g., (13)C NMR spectroscopy, infrared spectroscopy (FTIR), compositional analyses, and thermogravimetric analysis (TGA). Crystallographic data |(C15N2H32)(NH4)|[Ge11O21.5(OH)4], orthorhombic Ama2 (No. 40), a = 37.82959 Å, b = 15.24373 Å, c = 12.83659 Å, and Z = 8. PMID:23402209

Xu, Yan; Liu, Leifeng; Chevrier, Daniel M; Sun, Junliang; Zhang, Peng; Yu, Jihong

2013-09-16

417

Leukotoxin (9, 10-epoxy-12-octadecenoate) impairs energy and redox state of isolated perfused rat lung  

Microsoft Academic Search

We investigated the perturbation of energy balance and redox state in leukotoxin (9, 10-epoxy-12-octadecenoate) (Lx)- and endothelin-1 (ET-1)-induced lung injury, using isolated perfused rat lungs. To examine any relationship between these parameters, intracellular levels of adenine nucleotides, pyridine coenzymes and glutathione were determined by reversed-phase high-performance liquid chromatography (HPLC) in the freeze-dried tissues of isolated rat lungs. The tissue samples

Masaya Akai; Takeshi Ishizaki; Shigeru Matsukawa; Kazuo Shigemori; Isamu Miyamori

1998-01-01

418

Chromosome aberrations involving 10q22: report of three overlapping interstitial deletions and a balanced translocation disrupting C10orf11  

PubMed Central

Interstitial deletions of chromosome band 10q22 are rare. We report on the characterization of three overlapping de novo 10q22 deletions by high-resolution array comparative genomic hybridization in three unrelated patients. Patient 1 had a 7.9?Mb deletion in 10q21.3–q22.2 and suffered from severe feeding problems, facial dysmorphisms and profound mental retardation. Patients 2 and 3 had nearly identical deletions of 3.2 and 3.6?Mb, the proximal breakpoints of which were located at an identical low-copy repeat. Both patients were mentally retarded; patient 3 also suffered from growth retardation and hypotonia. We also report on the results of breakpoint analysis by array painting in a mentally retarded patient with a balanced chromosome translocation 46,XY,t(10;13)(q22;p13)dn. The breakpoint in 10q22 was found to disrupt C10orf11, a brain-expressed gene in the common deleted interval of patients 1–3. This finding suggests that haploinsufficiency of C10orf11 contributes to the cognitive defects in 10q22 deletion patients.

Tzschach, Andreas; Bisgaard, Anne-Marie; Kirchhoff, Maria; Graul-Neumann, Luitgard M; Neitzel, Heidemarie; Page, Stephanie; Ahmed, Alischo; Muller, Ines; Erdogan, Fikret; Ropers, Hans-Hilger; Kalscheuer, Vera M; Ullmann, Reinhard

2010-01-01

419

Rb6LiNd11Cl16(SeO3)12  

NASA Astrophysics Data System (ADS)

This document is part of Subvolume A10 'Structure Types. Part 10: Space Groups (140) I4/mcm - (136) P42/mnm' of Volume 43 'Crystal Structures of Inorganic Compounds' of Landolt-Börnstein - Group III 'Condensed Matter'.

Villars, P.; Cenzual, K.; Daams, J.; Gladyshevskii, R.; Shcherban, O.; Dubenskyy, V.; Kuprysyuk, V.; Savysyuk, I.; Zaremba, R.

420

De novo synthesis of trans-10, cis-12 conjugated linoleic acid in oleaginous yeast Yarrowia Lipolytica  

PubMed Central

Background Conjugated linoleic acid (CLA) has many well-documented beneficial physiological effects. Due to the insufficient natural supply of CLA and low specificity of chemically produced CLA, an effective and isomer-specific production process is required for medicinal and nutritional purposes. Results The linoleic acid isomerase gene from Propionibacterium acnes was expressed in Yarrowia lipolytica Polh. Codon usage optimization of the PAI and multi-copy integration significantly improved the expression level of PAI in Y. lipolytica. The percentage of trans-10, cis-12 CLA was six times higher in yeast carrying the codon-optimized gene than in yeast carrying the native gene. In combination with multi-copy integration, the production yield was raised to approximately 30-fold. The amount of trans-10, cis-12 CLA reached 5.9% of total fatty acid yield in transformed Y. lipolytica. Conclusions This is the first report of production of trans-10, cis-12 CLA by the oleaginous yeast Y. lipolytica, using glucose as the sole carbon source through expression of linoleic acid isomerase from Propionibacterium acnes.

2012-01-01

421

Long-pulse laser-plasma interactions at 10 to the 12th power-10 to the 15th power W\\/cm squared  

Microsoft Academic Search

Laser-plasma interaction physics including absorption, plasma formation, heating, plasma expansion and energy transport, are examined for 3-nsec Nd-laser irradiances between 10 to the 12th and 10 to the 15th power W\\/sq cm. Efficient energy deposition and conditions favorable to ablative acceleration are found at 10 to the 12th to 10 to the 13th power W\\/sq cm. whereas reduced absorption, hot

B. H. Ripin; R. R. Whitlock; F. C. Young; S. P. Obenschain; E. A. McLean

1979-01-01

422

One-pot, pseudo four-component synthesis of a spiro[diindeno[1,2-b:2',1'-e]pyridine-11,3'-indoline]-trione library.  

PubMed

A one-pot, pseudo four-component method for the efficient and simple synthesis of spiro[diindeno[1,2-b:2',1'-e]pyridine-11,3'-indoline]-2',10,12-trione derivatives in refluxing acetonitrile is reported. The features of this procedure are mild reaction conditions, high yields of products, and operational simplicity. PMID:19863100

Ghahremanzadeh, Ramin; Shakibaei, Ghazaleh Imani; Ahadi, Somayeh; Bazgir, Ayoob

2010-01-01

423

Bayesian Cloud Screening for GOES-12. Algorithm Theoretical Basis. Version 1.1.  

National Technical Information Service (NTIS)

This document presents the theoretical basis for the cloud screening and error estimation implemented within NOAA/NESDIS/ORA for GOES-12 cloud screening for sea surface temperature (SST) production, arising from a contract placed with the original author....

C. J. Merchant C. P. Old S. MacCallum

2004-01-01

424

Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells.  

PubMed

The anti-inflammatory cytokine IL-10 is a key modulator of immune responses. A better understanding of the regulation of this cytokine offers the possibility of tipping the balance of the immune response toward either tolerance, or enhanced immune responses. Histone deacetylases (HDACs) have been widely described as negative regulators of transcriptional regulation, and in this context, the primarily nuclear protein HDAC11 was shown to repress il-10 gene transcriptional activity in antigen-presenting cells (APCs). Here we report that another HDAC, HDAC6, primarily a cytoplasmic protein, associates with HDAC11 and modulates the expression of IL-10 as a transcriptional activator. To our knowledge, this is the first demonstration of two different HDACs being recruited to the same gene promoter to dictate divergent transcriptional responses. This dynamic interaction results in dynamic changes in the expression of IL-10 and might help to explain the intrinsic plasticity of the APC to determine T-cell activation versus T-cell tolerance. PMID:24747960

Cheng, Fengdong; Lienlaf, Maritza; Perez-Villarroel, Patricio; Wang, Hong-Wei; Lee, Calvin; Woan, Karrune; Woods, David; Knox, Tessa; Bergman, Joel; Pinilla-Ibarz, Javier; Kozikowski, Alan; Seto, Edward; Sotomayor, Eduardo M; Villagra, Alejandro

2014-07-01

425

12 CFR 1202.11 - What will it cost to get the records I requested?  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false What will it cost to get the records I requested...OF INFORMATION ACT § 1202.11 What will it cost to get the records I requested...fees, generally. FHFA or FHFA-OIG will assess you for fees covering...

2013-01-01

426

Collaborative Philosophical Enquiry for School Children: Socio-Emotional Effects at 11 to 12 Years  

ERIC Educational Resources Information Center

Two measures were used to investigate the socioemotional effects of collaborative philosophical enquiry on children aged 11 at pre-test in five experimental and three control primary (elementary) school mainstream classes. Experimental teachers received initial and follow-up professional development. In a pre-post controlled design, experimental…

Trickey, S.; Topping, K. J.

2006-01-01

427

Introduction to special issue commemorating the 10th anniversary of September 11, 2001.  

PubMed

Dr Boscarino was in the World Trade Center complex on September 11, 2001 when the first plane struck the Twin Towers. His World Trade Center work was supported in part by grants from the National Institute of Mental Health (Grants # R01 MH66403 and R21-MH-086317) and the Pennsylvania Department of Health (Contract #4100042573). PMID:21957720

Boscarino, Joseph A

2011-01-01

428

Background monitoring and long-range transport of atmospheric CFC-11 and CFC-12 at Kosan, Korea.  

PubMed

The background concentrations of atmospheric CFC-11 and CFC-12 were monitored to assess their impact on stratospheric ozone depletion and global warming from September 1995 to March 1999 at Kosan, Korea, located at eastern margin of the Asian Continent. The concentrations of atmospheric CFC-11 at Kosan have decreased slightly, at a rate of -2.5 pptv yr(-1), over the period in response to the Montreal Protocol. The CFC-12 mixing ratio at Kosan continues to increase in the atmosphere at a rate of 5.7 pptv yr(-1) despite international regulations, because of its extreme atmosphere persistence. Recent trends of these two chlorofluorocarbons at Kosan, Korea were concordant with those of the northern hemispheric background monitored unit at Mauna Loa, Hawaii. The maximum seasonal mean mixing ratios of CFC-11 and CFC-12 at Kosan, Korea, were 270 +/- 4 pptv in the spring and 538 +/- 9 pptv in the winter, and the corresponding seasonal minima were 267 +/- 7 and 529 +/- 12 pptv. This occurred in the summer and was due to southeasterly winds from the northwestern Pacific Ocean. By performing a three-day isentropic backward trajectory analysis, it was shown that air masses at Kosan, and with the exception of summer, mainly originated from central and northern China. In particular, the mixing ratios of these two contaminant species are closely related with their air mass trajectories. PMID:11516020

Kim, J; Oh, S N; Cho, H M; Park, M K; Kim, K R; Elkins, J W

2001-07-01

429

Cosmogenic 10Be and Paleoaccumulation Rates at WAIS Divide from 12-19 kyr BP  

NASA Astrophysics Data System (ADS)

Concentrations of cosmogenic 10Be in polar ice samples are affected by variations in solar activity, geomagnetic field strength, atmospheric mixing and annual snow accumulation rates. We are presently engaged in a study to obtain a continuous 10Be record in a deep ice core (WDC06A) that was drilled at the West Antarctic Ice Sheet (WAIS) Divide, a site with an average snow accumulation rate of ~20 cm weq/yr, similar to the GISP2 site in Greenland. We previously reported 10Be in annual layers in the top 114 m of WDC06A (Woodruff et al. 2011) and 10Be and 36Cl at decadal resolution in the top 560 m (Welten et al. 2009), and are now measuring 10Be in samples from a depth of 1800-2500 m, corresponding to preliminary ages of 10-20 kyr BP. We separated 10Be from ice samples of 300-600 g, following procedures described previously (Finkel and Nishiizumi 1997) and measured 10Be concentrations by accelerator mass spectrometry at PRIME lab. So far, we measured 10Be in 50 ice samples with ages between 12.3-13.9 kyr BP, at a resolution of ~30 yr/sample, and 50 samples from 15.6-19.0 kyr BP at an average resolution of ~70 yr/sample. The 10Be depth profile shows a relative constant value of (28 ± 3) x 10^3 atoms/g for samples younger than 18 kyr BP and a value of (41 ± 3) x 10^3 atoms/g for ice from 18.2-19.0 kyr BP. These values are 50-120% higher than the average concentration of 18.4 x 10^3 atoms/g for WAIS Divide ice samples from the last 420 year of snow accumulation. Although the higher 10Be concentrations in ice from the last glacial stage can be partly attributed to a 10-20% lower geomagnetic field strength (and thus a higher global 10Be production rate), they are mainly due to lower snow accumulation rates during the last glacial stage. After applying corrections for changes in geomagnetic field strength based on the SINT-800 record, we derive average snow accumulation rates of 13-15 cm weq/yr for the age interval of 12-18 kyr BP and of ~10 cm weq/yr for 18.2-19.0 kyr BP. A more complete 10Be depth profile will be presented at the meeting. Acknowledgment. This work was supported by NSF grants ANT-0839042 and 0839137. References. Finkel R. C. and Nishiizumi K. (1997). J. Geophys. Res. 102, 26,699-26,706. Welten K. C. et al. (2009) AGU Fall meeting, Abstract #C41A-0440. Woodruff T. E. et al. (2011) AGU Fall meeting, Abstract #C21A-0454.

Welten, K. C.; Woodruff, T. E.; Caffee, M. W.

2012-12-01

430

CFC-11, CFC-12 and CFC-113 indicating the sudden weakening of the thermohaline circulation in the Japan Sea  

NASA Astrophysics Data System (ADS)

The Japan Sea, which has a maximum depth of more than 3700m, is a marginal sea in the western North Pacific, and is connected to the North Pacific, East China Sea and Okhotsk Sea through four straits. Because these straits are shallower than 150m, the deep water in the Japan Sea, which is called the Japan Sea Proper Water (JSPW), is formed within the Sea itself. Past detailed studies have found that JSPW consists of three waters: the bottom water (lower layer of JSPW), the deep water (above the bottom water) and the upper JSPW (shallower than 1000m). The bottom water forms by ventilation in winter in the northern Japan Sea. While the turnover time of the bottom water is estimated about 100 years by using chemical tracers, long time-series datasets of dissolved oxygen and water temperature in the bottom water of the Japan Sea suggest that the thermohaline circulation in the sea had been weakening due to the global warming in recent decades. Therefore, we quantitatively analyzed the weakening by using measurements of CFC-11, CFC-12 and CFC-113 as water tracers. The high accuracy analysis system of dissolved CFCs in seawater was developed, and their vertical profiles were obtained from seven stations of the Japan Sea in June 2011. Each CFC was detected from surface to bottom at all stations. The detection of CFC-113 suggests that the bottom water has been formed even after the 1970s because air CFC-113 concentration began to increase since the 1960s, though those of CFC-11 and CFC-12 were since the 1930s. On the other hand, apparent ages of the bottom waters, which were estimated by the observed CFC-12/CFC-11 ratios and the time-series dataset of air CFC-12/CFC-11 ratio, were calculated to be about 50 years. The discrepancy between the detected CFC-113 and the apparent age of CFC-12/CFC-11 suggests that the information of apparent CFCs age of the bottom water was overwritten by mixing between original (old) water mass and new water mass caused by thermohaline circulation. Thus, correcting the apparent CFC-12/CFC-11 age with CFC-113 as an indicator of new bottom water formation, the turnover times of the bottom water formed before the 1970s and after the 1970s were computed about 100 years and more than 1000 years, respectively. The result suggests that the amount of new bottom water formation last 40 years suddenly decreased by less than one-tenth of that of before that.

Tanaka, S. S.; Aramaki, T.; Sasaki, K.; Isoda, Y.; Senjyu, T.; Kumamoto, Y.

2012-12-01

431

Trans-10,cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling  

PubMed Central

Lipid droplet-associated proteins play an important role in adipocyte triglyceride (TG) metabolism. Here, we show that trans-10,cis-12 conjugated linoleic acid (CLA), but not cis-9,trans-11 CLA, increased lipolysis and altered human adipocyte lipid droplet morphology. Before this change in morphology, there was a rapid trans-10,cis-12 CLA-induced increase in the accumulation of perilipin A in the cytosol, followed by the disappearance of perilipin A protein. In contrast, protein levels of adipose differentiation-related protein (ADRP) were increased in cultures treated with trans-10,cis-12 CLA. Immunostaining revealed that ADRP localized to the surface of small lipid droplets, displacing perilipin. Intriguingly, trans-10,cis-12 CLA increased ADRP protein expression to a much greater extent than ADRP mRNA without affecting stability, suggesting translational control of ADRP. To this end, we found that trans-10,cis-12 CLA increased activation of the mammalian target of rapamycin/p70 S6 ribosomal protein kinase/S6 ribosomal protein (mTOR/p70S6K/S6) pathway. Collectively, these data demonstrate that the trans-10,cis-12 CLA-mediated reduction of human adipocyte TG content is associated with the differential localization and expression of lipid droplet-associated proteins. This process involves both the translational control of ADRP through the activation of mTOR/p70S6K/S6 signaling and transcriptional control of perilipin A.

Chung, Soonkyu; Brown, Jonathan Mark; Sandberg, Maria Boysen; McIntosh, Michael

2005-01-01

432

11 CFR 102.10 - Disbursement by check (2 U.S.C. 432(h)(1)).  

Code of Federal Regulations, 2011 CFR

... false Disbursement by check (2 U.S.C. 432(h)(1)). 102.10 Section 102...RECORDKEEPING BY POLITICAL COMMITTEES (2 U.S.C. 433) § 102.10 Disbursement by check (2 U.S.C. 432(h)(1)). All disbursements...

2014-01-01

433

Identification of a rat bone marrow-derived dendritic cell population which secretes both IL10 and IL12: Evidence against a reciprocal relationship between IL10 and IL12 secretion  

Microsoft Academic Search

The qualitative nature of immune responses induced by dendritic cells (DCs) is influenced by the balance of pro-inflammatory (e.g. IL-12) and anti-inflammatory (e.g. IL-10) cytokines that they secrete. Evidence to date suggests that IL-12 and IL-10 secretion is reciprocally regulated and that IL-10 inhibits IL-12 secretion. This study identifies a population of resting, immature rat bone marrow-derived DCs (BMDCs) which

Munitta Muthana; Barbara Fairburn; Shabana Mirza; Laura K. Slack; Kay Hopkinson; Alan G. Pockley

2006-01-01

434

Boric acid adsorption on humic acids: Ab initio calculation of structures, stabilities, 11B NMR and 11B, 10B isotopic fractionations of surface complexes  

NASA Astrophysics Data System (ADS)

Boric acid, B(OH) 3, forms complexes in aqueous solution with a number of bidentate O-containing ligands, HL -, where H 2L is C 2O 4H 2 (oxalic acid), C 3O 4H 4 (malonic acid), C 2H 6O 2 (ethylene glycol), C 6H 6O 2 (catechol), C 10H 8O 2 (dioxynaphthalene) and C 2O 3H 4 (glycolic acid). McElligott and Byrne [McElligott, S., Byrne, R.H., 1998. Interaction of B(OH)30 and HCO3- in seawater: Formation of B(OH)CO3-. Aquat. Geochem.3, 345-356.] have also found B(OH) 3 to form an aqueous complex with HCO3-1. Recently Lemarchand et al. [Lemarchand, E., Schott, J., Gaillardeet, J., 2005. Boron isotopic fractionation related to boron sorption on humic acid and the structure of surface complexes formed. Geochim. Cosmochim. Acta69, 3519-3533] have studied the formation of surface complexes of B(OH) 3 on humic acid, determining 11B NMR shifts and fitted values of formation constants, and 11B, 10B isotope fractionations for a number of surface complexation models. Their work helps to clarify both the nature of the interaction of boric acid with the functional groups in humic acid and the nature of some of these coordinating sites on the humic acid. The determination of isotope fractionations may be seen as a form of vibrational spectroscopy, using the fractionating element as a local probe of the vibrational spectrum. We have calculated quantum mechanically the structures, stabilities, vibrational spectra, 11B NMR spectra and 11B, 10B isotope fractionations of a number of complexes B(OH) 2L - formed by reactions of the type: B(OH)3+HL-?B(OH)2L+HO using a 6-311G(d,p) basis set and the B3LYP method for determination of structures, vibrational frequencies and isotopic fractionations, the highly accurate Complete Basis Set-QB3 method for calculating the free energies and the GIAO HF method with a 6-311+G(2d,p) basis for the NMR shieldings. The calculations indicate that oxalic acid, malonic acid, catechol and glycolic acid all form stable complexes (? G < 0 for Reaction (1)),which are deshielded (less negative ?) vs. the (C 2H 5) 2OBF 3 reference by 3.6, 1.5, 6.5 and 5.4 ppm, respectively, and which are isotopically lighter than B(OH)4- (more negative ? 11B) by 3‰, 2‰, 5‰ and 2‰, respectively. The calculated 11B NMR shifts match well literature values and with the results of Lemarchand et al. (2005), while the calculated isotopic fractionations are also consistent with their results, but show much smaller deviations from B(OH)4-t than indicated by these authors. This is a consequence of the use by Lemarchand et al. (2005) of a value of 1.0194 [Kakihana, H., Kotake, M., Satoh, S., Nomura, M., Okamoto, M., 1977. Fundamental studies on the ion-exchange separation of boron isotopes. Bull. Chem. Soc. Jpn.50, 158-163.] for the 11B, 10B isotopic exchange equilibrium constant of the B(OH) 3, B(OH)4- pair which is obsolete and should be replaced by the new purely experimentally determined value of 1.0285 for 0.63 molar ionic strength [Byrne, R.H., Yao, W., Klochko, K., Kaufman, A.J., Tossell, J.A., 2006. Experimental evaluation of the isotopic exchange equilibrium 10B(OH)+11B(OH)4-=11B(OH)+10B(OH)4-in aqueous solution. Deep-Sea Res. 1 (53), 684-688.] or 1.0308 for pure water [Klochko, K., Kaufman, A.J., Yao, W., Byrne, R.H., Tossell, J.A., 2006. Experimental measurement of boron isotope fractionation in seawater. Earth Planet Sci. Lett. 248, 276-285]. Given this correction the B(OH) 2L - complexes are observed to be isotopically lighter than B(OH)4- by only a few ‰. Changes in 11B NMR shift and 11B, 10B isotope fractionations for the B(OH) 2L - complexes, compared to B(OH)4-, are found to be correlated to some extent with distortions of the O-B-O angles from tetrahedral values and/or with B-O bond strength sums. Similar free energies for the corner-sharing and 4-ring isomers of B(OH)CO3- suggest a mechanism for creation of both BIII and BIV environments when B is incorporated into calcite.

Tossell, J. A.

2006-10-01

435

Coincidence analyzing-power measurements of the reaction sup 12 C( rvec p , p prime. gamma. ) sup 12 C sup * through the 15. 11-MeV state  

SciTech Connect

Coincidence analyzing-power measurements or asymmetries {ital A}{sub {ital x}}{sup coinc}, {ital A}{sub {ital y}}{sup coinc}, and {ital A}{sub {ital z}}{sup coinc} are presented for the {sup 12}C({ital {rvec p}},{ital p}{prime}{gamma}){sup 12}C{sup *} (15.11 MeV) reaction. A polarized proton beam at 318 MeV was used and data were obtained for three mutually perpendicular directions of polarization. A scintillator hodoscope was used for detecting scattered protons and four BGO detectors for the 15.11-MeV {gamma} rays. Data are presented for eight azimuthal directions of the scattered protons around the beam direction, and for the polar angles averaged between 3.3{degree} and 11.2{degree}. The data are compared with both nonrelativistic and relativistic calculations. The average size of the asymmetries measured is somewhat less than both predictions and the results do not agree clearly with either prediction.

Lyndon, C.R.; Funsten, H.O.; Perdrisat, C.F.; Punjabi, V.; Finn, J.M. (Department of Physics, The College of William and Mary, Williamsburg, Virginia 23185 (United States)); Lieb, B.J. (Department of Physics, George Mason University, Fairfax, Virginia 22030 (United States)); Stronach, C.E.; Fuqua, N.L. (Department of Physics, Virginia State University, Petersburg, Virginia 23803 (United States)); Plendl, H.S.; Mackenzie, J.R.; Nair, R. (Department of Physics, Florida State University, Tallahassee, Florida 32306 (United States)); Comfort, J.R.; Giannelli, R.A. (Department of Physics, Arizona State University, Tempe, Arizona 85287 (United States)); Reidy, J.J.; Redmond, L. (Department of Physics, University of Mississippi, University, Mississippi 38677 (United States)); Koehler, P.E.; Wender, S.A. (Los Alamos National Laboratory, Los Alamos, New Mexico 87545 (United States))

1992-01-01

436

Trapped Solar Wind Noble Gases in APOLLO 12 Lunar Fines 12001 and APOLLO 11 Breccia 10046.  

National Technical Information Service (NTIS)

The concentrations and isotopic composition of the five noble gases were measured in an unseparated bulk sample of the Apollo 12 fines 12001, in seven bulk and five ilmenite grain size fractions from 12001, and in four ilmenite grain size fractions separa...

P. Eberhardt J. Geiss H. Graf N. Groegler M. D. Mendia

1972-01-01

437

CBAL: Results from Piloting Innovative K-12 Assessments. Research Report. ETS RR-11-23  

ERIC Educational Resources Information Center

CBAL, an acronym for Cognitively Based Assessment of, for, and as Learning, is a research initiative intended to create a model for an innovative K-12 assessment system that provides summative information for policy makers, as well as formative information for classroom instructional purposes. This paper summarizes empirical results from 16 CBAL…

Bennett, Randy Elliot

2011-01-01

438

The VP8* Domain of Neonatal Rotavirus Strain G10P[11] Binds to Type II Precursor Glycans  

PubMed Central

Naturally occurring bovine-human reassortant rotaviruses with a P[11] VP4 genotype exhibit a tropism for neonates. Interaction of the VP8* domain of the spike protein VP4 with sialic acid was thought to be the key mediator for rotavirus infectivity. However, recent studies have indicated a role for nonsialylated glycoconjugates, including histo-blood group antigens (HBGAs), in the infectivity of human rotaviruses. We sought to determine if the bovine rotavirus-derived VP8* of a reassortant neonatal G10P[11] virus interacts with hitherto uncharacterized glycans. In an array screen of >600 glycans, VP8* P[11] showed specific binding to glycans with the Gal?1-4GlcNAc motif, which forms the core structure of type II glycans and is the precursor of H type II HBGA. The specificity of glycan binding was confirmed through hemagglutination assays; GST-VP8* P[11] hemagglutinates type O, A, and B red blood cells as well as pooled umbilical cord blood erythrocytes. Further, G10P[11] infectivity was significantly enhanced by the expression of H type II HBGA in CHO cells. The bovine-origin VP4 was confirmed to be essential for this increased infectivity, using laboratory-derived reassortant viruses generated from sialic acid binding rotavirus SA11-4F and a bovine G10P[11] rotavirus, B223. The binding to a core glycan unit has not been reported for any rotavirus VP4. Core glycan synthesis is constitutive in most cell types, and modification of these glycans is thought to be developmentally regulated. These studies provide the first molecular basis for understanding neonatal rotavirus infections, indicating that glycan modification during neonatal development may mediate the age-restricted infectivity of neonatal viruses.

Ramani, Sasirekha; Cortes-Penfield, Nicolas W.; Hu, Liya; Crawford, Sue E.; Czako, Rita; Smith, David F.; Kang, Gagandeep; Ramig, Robert F.; Le Pendu, Jacques; Prasad, B. V. Venkataram

2013-01-01

439

Interstellar H3(+) - Possible detection of the 1(10)-1(11) transition of H2D  

NASA Technical Reports Server (NTRS)

An interstellar line has been detected in emission at the expected submillimeter wavelength of the 1(10)-1(11) transition of H2D(+), the deuterated verison of the primary ion (H3/+/) in the favored ion-molecule reaction scheme for interstellar gas phase chemistry. The strength of the line is in approximate agreement with the theoretically anticipated H2D(+) abundance.

Phillips, T. G.; Blake, G. A.; Keene, J.; Woods, R. C.; Churchwell, E.

1985-01-01

440

10 Gbit\\/s photonic crystal fiber transmissions with 1.1 ?m directly-modulated single-mode VCSEL  

Microsoft Academic Search

We demonstrate a 10-Gbit\\/s transmission over a 5-km photonic crystal fiber in the 1.1 ?m band using a directly-modulated single-mode VCSEL. The transmission distance was extended to 14 km by using an ytterbium-doped fiber amplifier.

Kengo Koizumi; Masato Yoshida; Toshihiko Hirooka; M. Nakazawa

2010-01-01

441

77 FR 6669 - Airworthiness Directives; Honeywell International Inc. TPE331-10 and TPE331-11 Series Turboprop...  

Federal Register 2010, 2011, 2012, 2013

...2120-AA64 Airworthiness Directives; Honeywell International Inc. TPE331-10 and TPE331-11...information identified in this AD, contact Honeywell International Inc., 111 S. 34th Street...direct); Web site: http://portal.honeywell.com. You may review copies of...

2012-02-09

442

76 FR 48749 - Airworthiness Directives; Honeywell International Inc. TPE331-10 and TPE331-11 Series Turboprop...  

Federal Register 2010, 2011, 2012, 2013

...2120-AA64 Airworthiness Directives; Honeywell International Inc. TPE331-10 and TPE331-11...identified in this proposed AD, contact Honeywell International Inc., 111 S. 34th Street...2802; Web site: http://portal.honeywell.com; or call Honeywell toll...

2011-08-09

443

Investigation of Excited States of B11 and Li7 by Means of Thermal Neutron Capture on B10 Nuclei.  

National Technical Information Service (NTIS)

The gamma-radiation from the B10 (n, gamma) reaction was studied using an unpolarized target. More accurate values for energies of transitions in B11 are determined. No new levels are found. The Q value of 11454.1(2) keV agrees with earlier experiments. T...

P. J. J. Kok J. B. M. Dehaas K. Abrahams H. Postma W. J. Huiskamp

1986-01-01

444

Performance Study of Access Control in Wireless LANs - IEEE 802.11 DFWMAC and ETSI RES 10 Hiperlan  

Microsoft Academic Search

Currently two projects are on their way to standardizephysical layer and medium access control for wirelessLANs - IEEE 802.11 and ETSI RES10 Hiperlan. Thispaper presents an introduction to both projects focussingon the applied access schemes. Fyrther we will presentour simulation results, analyzing the performance ofboth access protocols depending on the number of stationsand on the packet size, evaluating them regardingtheir

Jost Weinmiller; Morten Schläger; Andreas Festag; Adam Wolisz

1997-01-01

445

Evaluation of Low-Cost, Objective Instruments for Assessing Physical Activity in 10-11-Year-Old Children  

ERIC Educational Resources Information Center

This study compared step counts detected by four, low-cost, objective, physical-activity-assessment instruments and evaluated their ability to detect moderate-to-vigorous physical activity (MVPA) compared to the ActiGraph accelerometer (AG). Thirty-six 10-11-year-old children wore the NL-1000, Yamax Digiwalker SW 200, Omron HJ-151, and Walk4Life…

Hart, Teresa L.; Brusseau, Timothy; Kulinna, Pamela Hodges; McClain, James J.; Tudor-Locke, Catrine

2011-01-01

446

1,1'-azobis(tetrazole): a highly energetic nitrogen-rich compound with a N10 chain.  

PubMed

The reaction of 1-aminotetrazole with acidic sodium dichloroisocyanurate allowed isolation of 1,1'-azobis(tetrazole). The rare chain of 10 nitrogen atoms in this compound was confirmed by X-ray crystallography, and the physical and explosive properties of the azo compound were characterized. The title compound possesses both exceedingly high explosive performance and sensitivity. PMID:21384800

Klapötke, Thomas M; Piercey, Davin G

2011-04-01

447

Internet Use and Psychological Well-Being among 10-Year-Old and 11-Year-Old Children  

ERIC Educational Resources Information Center

This paper uses data from the 2009 Kids' Life and Times Survey, involving 3657 children aged 10 or 11 years old in Northern Ireland. The survey indicated high levels of use of Internet applications, including social-networking sites and online games. Using the KIDSCREEN-27 instrument, the data indicate that the use of social-networking sites and…

Devine, Paula; Lloyd, Katrina

2012-01-01

448

Teachers' and Pupils' Behavior in Large and Small Classes: A Systematic Observation Study of Pupils Aged 10 and 11 Years  

ERIC Educational Resources Information Center

The authors examined class size effects on teacher-pupil interactions, pupil engagement, and pupil-pupil interaction. They extended previous research by recognizing the hierarchical nature of observation data and the possible influence of other variables. The study used a time sampling method involving 257 children (aged 10-11 years) in 16 small…

Blatchford, Peter; Bassett, Paul; Brown, Penelope

2005-01-01

449

Absolute band strengths of halocarbons F-11 and F-12 in the 8- to 16-micron region  

NASA Technical Reports Server (NTRS)

The infrared strengths of three vibrational band systems of halocarbon F-11 and four vibrational band systems of halocarbon F-12 in the 'atmospheric window' between 8 and 16 microns were measured at 296 + or - 1 K using a Fourier transform infrared spectrometer. These results were obtained at a maximum instrumental resolution of 0.06/cm. The measurements of the total infrared band strengths for F-11 and F-12 would indicate approximately 17% and 5% greater absorbance, respectively, than those strengths used in recent greenhouse warming calculations by Ramanathan (1975), Wang et al. (1976), and Lacis et al. (1981), and consequently, a corresponding increase in the possible atmospheric warming effect by these halocarbons.

Kagann, R. H.; Elkins, J. W.; Sams, R. L.

1983-01-01

450

Expression of CXCR3 and its ligands CXCL9, -10 and -11 in paediatric opsoclonus-myoclonus syndrome.  

PubMed

Opsoclonus-myoclonus syndrome (OMS) is a neuroinflammatory disorder associated with remote cancer. To understand more clearly the role of inflammatory mediators, the concentration of CXCR3 ligands CXCL10, CXCL9 and CXCL11 was measured in 245 children with OMS and 81 paediatric controls using enzyme-linked immunosorbent assay (ELISA), and CXCR3 expression on CD4(+) T cells was measured by flow cytometry. Mean cerebrospinal fluid (CSF) CXCL10 was 2·7-fold higher in untreated OMS than controls. Intrathecal production was demonstrated by significantly different CXCL10 CSF?:?serum ratios. The dichotomized 'high' CSF CXCL10 group had higher CSF leucocyte count (P?=?0·0007) and B cell activating factor (BAFF) and CXCL13 concentrations (P?10 did not correlate with clinical severity or relapse using grouped data, although it did in some patients. Among seven types of immunotherapy, including rituximab or chemotherapy, only adrenocorticotrophic hormone (ACTH) monotherapy showed reduced CSF CXCL10, but prospective longitudinal studies of ACTH combination therapies indicated no reduction in CXCL10 despite clinical improvement (P?10 concentrations were 11-fold higher in CSF and twofold higher in serum by multiplexed fluorescent bead-based immunoassay than enzyme-linked immunosorbent assay, but the two correlated (r?=?0·7 and 0·83). In serum, no group differences for CXCL9 or CXCL11 were found. CXCR3 expression on CD4(+) T cells was fivefold higher in those from CSF than blood, but was not increased in OMS or altered by conventional immunotherapy. These data suggest alternative roles for CXCL10 in OMS. Over-expression of CXCL10 was not reduced by clinical immunotherapies as a whole, indicating the need for better therapeutic approaches. PMID:23600831

Pranzatelli, M R; Tate, E D; McGee, N R; Travelstead, A L; Verhulst, S J; Ransohoff, R M

2013-06-01

451

Expression of CXCR3 and its ligands CXCL9, -10 and -11 in paediatric opsoclonus-myoclonus syndrome  

PubMed Central

Opsoclonus–myoclonus syndrome (OMS) is a neuroinflammatory disorder associated with remote cancer. To understand more clearly the role of inflammatory mediators, the concentration of CXCR3 ligands CXCL10, CXCL9 and CXCL11 was measured in 245 children with OMS and 81 paediatric controls using enzyme-linked immunosorbent assay (ELISA), and CXCR3 expression on CD4+ T cells was measured by flow cytometry. Mean cerebrospinal fluid (CSF) CXCL10 was 2·7-fold higher in untreated OMS than controls. Intrathecal production was demonstrated by significantly different CXCL10 CSF : serum ratios. The dichotomized ‘high’ CSF CXCL10 group had higher CSF leucocyte count (P = 0·0007) and B cell activating factor (BAFF) and CXCL13 concentrations (P < 0·0001). CSF CXCL10 did not correlate with clinical severity or relapse using grouped data, although it did in some patients. Among seven types of immunotherapy, including rituximab or chemotherapy, only adrenocorticotrophic hormone (ACTH) monotherapy showed reduced CSF CXCL