Note: This page contains sample records for the topic 10 11 12 from Science.gov.
While these samples are representative of the content of Science.gov,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of Science.gov
to obtain the most current and comprehensive results.
Last update: November 12, 2013.
1

ABCC10, ABCC11, and ABCC12  

Microsoft Academic Search

Multidrug resistance protein (MRP)7, MRP8, and MRP9 (gene symbols ABCC10, ABCC11, and ABCC12) are recently identified members\\u000a of the MRP family that are at relatively early stages of investigation. Of these proteins, a physiological function has only\\u000a been established for MRP8, for which a single nucleotide polymorphism determines wet vs dry earwax type. MRP7 and MRP8 are\\u000a lipophilic anion pumps

Gary D. Kruh; Yanping Guo; Elizabeth Hopper-Borge; Martin G. Belinsky; Zhe-Sheng Chen

2007-01-01

2

Framing 10\\/12 and 3\\/11 in American and European News  

Microsoft Academic Search

This media analysis of the incidents in Bali in 2002 (10\\/12) and Madrid in 2004 (3\\/11) reveals the black and white portrayal of these attacks in western news through the localization of international terrorism occurrences, pro-government perspective, and internalization of U.S. policies. The Old Europe and New Europe debate further fractures the European press. Such rhetoric perpetuates the \\

Andrea Lypka

2011-01-01

3

Isomerization of 9c11t\\/10t12c CLA in Triacylglycerols  

Microsoft Academic Search

Isomers of conjugated linoleic acid from 7t9c through 12t14t can be induced by thermal treatment of triacylglycerol samples\\u000a of 9c11t or 10t12c fatty acids in glass tubes. The formation of conjugated linoleic acids (CLAs) has been observed during\\u000a thermal induction of the above-mentioned triacylglycerols at 250, 280 and 320°C. The concentrations of isomers formed in the\\u000a mixture varied depending on

Alfred A. Christy

2010-01-01

4

Features of clathrate formation of trans -9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboxylic acid  

Microsoft Academic Search

Structural data illustrating various ways of association of the molecules of host and guest observed in the clathrates of\\u000a trans-9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboxylic acid (DED) with chloroform, ethyl propionate, 1,4-dioxane and acetone\\u000a are presented. The following types of host-guest interactions are considered: “true clathrate” without host-guest hydrogen\\u000a bonds (DED + chloroform, DED + ethyl propionate), infinite associate (DED + 1,4-dioxane) and discrete associate

L. Yu. Izotova; D. M. Ashurov; B. T. Ibragimov; E. Weber; M. Perren; S. A. Talipov

2005-01-01

5

2,2,3,3,11,11,12,12-Octamethyl-1,4,7,10,13-pentaoxacyclohexadecane: improved synthesis and crystal structure with NaSCN  

SciTech Connect

An efficient synthesis of 2,2,3,3,11,11,12,12-octamethyl-1,4,7,10,13-pentaoxacyclohexadecane (1, OM16C5) is described, which affords over an order of magnitude improvement in yield over the previously reported method. The first X-ray crystal structure of 1, as a complex with NaSCN, is also reported. There is much interest in sodium-selective ionophores [1,2] for use in electrodes [1,3] and optodes [4]. One such ionophore is 2,2,3,3,11,11,12,12-octamethyl-1,4,7,10,13-pentaoxacyclohexadecane (1, octamethyl-16-crown-5 or OM16C5), which was first prepared in 1996 by Suzuki and coworkers [1]. The synthetic procedure as reported and shown in Scheme 1 involved three steps starting from pinacol. The first two steps proceeded in excellent (95%) and good (ca. 81%) yields, respectively. However, the cyclization step, involving the addition of diethylene glycol dimesylate to 2,3,3,9,9,10-hexamethyl-4,8-dioxa-2,10-undecanediol (2) using NaH in THF, proceeded poorly with a low (3.7%) isolated yield, making the overall yield for the three steps starting from pinacol approximately 2.8%. We were interested in this crown ether for alkali-metal extraction studies, and sought to improve the yield so that larger (potentially gram) quantities of material could be readily prepared. We report here a modification of the synthetic procedure that boosts the conversion of 1 from 2 over 15-fold, by using three good- to high-yielding steps that allows 1 to be obtained from 2 in a combined yield of 59%. We also report for the first time a crystal structure of 1, as the NaSCN complex

Loustau-Chartez, Ms. Fanny [Ecole Nationale Superieure de Chimie de Paris; Robeson, Rachel M [ORNL; Custelcean, Radu [ORNL; Sachleben, Richard A. [Momenta Pharmaceuticals; Bonnesen, Peter V [ORNL

2009-01-01

6

Sequential substitution of 1,2dichloroethene: a convenient stereoselective route to (9Z,11E)-, (10E,12Z)- and (10Z,12Z)-[1- 14C] conjugated linoleic acid isomers  

Microsoft Academic Search

Conjugated linoleic acid (CLA) isomers are present in human foods derived from milk or ruminant meat. To study their metabolism, (9Z,11E)-, (10E,12Z)- and (10Z,12Z)-[1-14C]-octadecadienoic acids with high radiochemical and isomeric purities (>98%) were prepared by stereoselective multi-step syntheses involving sequential substitution of 1,2-dichloro-ethene. In the case of the (9Z,11E) isomer, a first metal-catalyzed cross-coupling reaction between (E)-1,2-dichloro-ethene and 2-non-8-ynyloxy-tetrahydro-pyran, obtained

O. Loreau; A. Maret; J. M. Chardigny; J. L. Sébédio; J. P. Noël

2001-01-01

7

A Teacher's Guide to Folksinging: A Mini-Elective for Students in Grades 9, 10, 11, and 12.  

ERIC Educational Resources Information Center

|To help meet the needs of nonmusic-major students in grade 9, 10, 11, and 12, this teacher's guide offers guidelines for a course to stimulate students' interest and involvement in folksinging. Guidelines are provided on the role of the teacher, methods of instruction, and suggested time allotments. Brief descriptions and comments on some typical…

New York State Education Dept., Albany. Bureau of Secondary Curriculum Development.

8

Chromosome 10p11.2-p12.2 duplication: report of a patient and review of the literature.  

PubMed

We report on a young male with mental retardation, slightly upslanting palpebral fissures, strabismus, high-arched palate, retrognathia, and flat feet. Cytogenetic analysis in addition to fluorescent in situ hybridization (FISH) and comparative genomic hybridization (CGH) showed the presence of a chromosome 10p11.2-->p12.2 duplication. Karyotypes of the parents were normal. Comparison of the clinical findings observed in the present patient with those observed in other reported cases with duplication 10p suggest that the presence of high arched/cleft palate and retrognathia may be related to the 10p11.2-->p12.2 duplication. Also, no critical region for the trisomy 10p syndrome has been delimited. PMID:11754045

Mégarbané, A; Gosset, P; Souraty, N; Lapierre, J M; Korban, R; Zahed, L; Samaras, L; Vekemans, M; Prieur, M

2001-12-01

9

The characterization of ficaprenol-10, -11 and -12 from the leaves of Ficus elastica (decorative rubber plant)  

PubMed Central

Evidence from mass, nuclear-magnetic-resonance and infrared spectrometry and from gas–liquid and thin-layer chromatography is presented in favour of the presence of cis–trans-decaprenol, -undecaprenol and -dodecaprenol in the mixture of polyprenols (2·6mg./g.) isolated from leaf tissue of Ficus elastica. The trivial names ficaprenol-10, -11 and -12 are proposed. Nuclear-magnetic-resonance studies showed that each of these prenols contains three trans internal isoprene residues and a cis `OH-terminal' isoprene residue. Ficaprenol-11 is the major component of the mixture. Chromatographic evidence suggests the presence also of small amounts of ficaprenol-9 and -13. The precise position of the three trans internal isoprene residues was not determined but it is suggested that these are adjacent to the ?-terminal isoprene residue and that the ficaprenols are formed from all-trans-geranylgeranyl pyrophosphate. It is also suggested that ficaprenol-10, -11, -12 and -13 are probably the same compounds as castaprenol-10, -11, -12 and -13.

Stone, K. J.; Wellburn, A. R.; Hemming, F. W.; Pennock, J. F.

1967-01-01

10

21 CFR 573.637 - Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic...  

Code of Federal Regulations, 2010 CFR

...false Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic acids). 573.637 Section...637 Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10,...

2009-04-01

11

17 CFR 240.12b-25 - Notification of inability to timely file all or any required portion of a Form 10-K, 20-F, 11-K...  

Code of Federal Regulations, 2010 CFR

...10-K, 20-F, 11-K, N-SAR, N-CSR, 10-Q, or 10-D. 240.12b-25...10-K, 20-F, 11-K, N-SAR, N-CSR, 10-Q, or 10-D. Link to an amendment...annual or transition report on Form N-CSR (17 CFR 249.331; 17 CFR...

2009-04-01

12

21 CFR 573.637 - Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic...  

Code of Federal Regulations, 2013 CFR

... Methyl esters of conjugated linoleic acid (cis-9, trans-11 and trans-10, cis-12-octadecadienoic acids). 573.637 Section 573.637 Food... Methyl esters of conjugated linoleic acid (cis-9, trans-11 and...

2013-04-01

13

Synthesis of novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones and evaluation of their biocidal effects.  

PubMed

Novel 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-thiones have been synthesized in high yields by treatment of the corresponding oxo analogs with Lawesson's reagent. The structure has been confirmed by X-ray analysis. The compounds were tested for in vitro antifungal activity against Rhizoctonia bataticola, Sclerotium rolfsii, Fusarium oxysporum and Alternaria porii. The compounds exhibited moderate to good activity against all pathogens. Insecticidal activity of these compounds against Spodoptera litura was observed to be comparable to commercial pyrethroid insecticide, cypermethrin. The urease inhibitory activity has also been studied. PMID:23153816

Khurana, Jitender M; Magoo, Devanshi; Aggarwal, Komal; Aggarwal, Nisha; Kumar, Rajesh; Srivastava, Chitra

2012-10-25

14

Diels-Alder reactions of 12-hydroxy-9(10®20)-5aH-abeo-abieta-1(10),8(9),12(13)-triene-11,14-dione.  

PubMed

12-Hydroxy-9(10-->20)-5aH-abeo-abieta-1(10),8(9),12(13)-triene-11,14-dione (quinone 2) served as the dienophile in numerous intermolecular Diels-Alder reactions. These cycloadditions were conducted either thermally (including microwave heating) or with Lewis acid activation. While most dienes reacted with quinone 2 in good chemical yield, others were incompatible under the experimental conditions used. PMID:23771059

Majetich, George; Zhang, Yong; Tian, Xinrong; Zou, Ge; Li, Yang; Wang, Yangyang; Hu, Shougang; Huddleston, Eric

2013-06-14

15

Sequencing and association analysis of the type 1 diabetes - linked region on chromosome 10p12-q11  

PubMed Central

Background In an effort to locate susceptibility genes for type 1 diabetes (T1D) several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in a combined analysis of the main linkage scans. Here, we studied sequence polymorphisms in 23 Mb on chromosome 10p12-q11, including the putative IDDM10 region, to identify genes associated with T1D. Results Initially, we resequenced the functional candidate genes, CREM and SDF1, located in this region, genotyped 13 tag single nucleotide polymorphisms (SNPs) and found no association with T1D. We then undertook analysis of the whole 23 Mb region. We constructed and sequenced a contig tile path from two bacterial artificial clone libraries. By comparison with a clone library from an unrelated person used in the Human Genome Project, we identified 12,058 SNPs. We genotyped 303 SNPs and 25 polymorphic microsatellite markers in 765 multiplex T1D families and followed up 22 associated polymorphisms in up to 2,857 families. We found nominal evidence of association in six loci (P = 0.05 – 0.0026), located near the PAPD1 gene. Therefore, we resequenced 38.8 kb in this region, found 147 SNPs and genotyped 84 of them in the T1D families. We also tested 13 polymorphisms in the PAPD1 gene and in five other loci in 1,612 T1D patients and 1,828 controls from the UK. Overall, only the D10S193 microsatellite marker located 28 kb downstream of PAPD1 showed nominal evidence of association in both T1D families and in the case-control sample (P = 0.037 and 0.03, respectively). Conclusion We conclude that polymorphisms in the CREM and SDF1 genes have no major effect on T1D. The weak T1D association that we detected in the association scan near the PAPD1 gene may be either false or due to a small genuine effect, and cannot explain linkage at the IDDM10 region.

Nejentsev, Sergey; Smink, Luc J; Smyth, Deborah; Bailey, Rebecca; Lowe, Christopher E; Payne, Felicity; Masters, Jennifer; Godfrey, Lisa; Lam, Alex; Burren, Oliver; Stevens, Helen; Nutland, Sarah; Walker, Neil M; Smith, Anne; Twells, Rebecca; Barratt, Bryan J; Wright, Charmain; French, Lisa; Chen, Yuan; Deloukas, Panagiotis; Rogers, Jane; Dunham, Ian; Todd, John A

2007-01-01

16

Effects of 9 cis ,11 trans and 10 trans ,12 cis CLA on osteoclast formation and activity from human CD14+ monocytes  

Microsoft Academic Search

Background  Mixed CLA isomers variably affect bone resorption in animals and decrease osteoclast formation and activity in murine osteoclasts.\\u000a These variable effects may be due to the different isomers present in commercial preparations of CLA, and the effects of the\\u000a predominant individual isomers, 9 cis,11 trans (9,11) and 10 trans,12 cis (10,12) CLA are not clear. The objectives of this study

Ilana Platt; Ahmed El-Sohemy

2009-01-01

17

9Hydroxy10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE): excellent markers for lipid peroxidation  

Microsoft Academic Search

Various conditions for conversion of (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoic acid (9S-HPODE) and (13S,9Z,10E)-13-hydroperoxy-9,11-octadecadienoic acid (13S-HPODE) into the corresponding hydroxy acids, (9S,10E,12Z)-9-hydroxy-10,12-octadecadienoic acid (9S-HODE) and (13S,9Z,10E)-13-hydroxy-9,11-octadecadienoic acid (13S-HODE), were investigated in vitro. 9S-HODE and 13S-HODE were subjected to lipid peroxidation under various conditions: oxidation was carried out in air only, and in air\\/Fe2+\\/ascorbate, air\\/H2O2\\/Fe2+, air\\/Fe2+, and air\\/Fe3+. In contrast to the corresponding hydroperoxides (9S-HPODE

Peter Spiteller; Gerhard Spiteller

1997-01-01

18

Interdisciplinary Student/Teacher Materials in Energy, the Environment, and the Economy: Agriculture, Energy, and Society, Grades 10, 11, 12.  

ERIC Educational Resources Information Center

|This interdisciplinary instructional unit contains eleven lessons for grades 10-12 which focus on the energy component of food production. There are lessons which contrast food production systems in various cultures and also lessons which look at different systems and techniques in use in this country. There are lessons dealing with organic…

Brock, Phyllis; And Others

19

Interdisciplinary Student/Teacher Materials in Energy, the Environment, and the Economy: Agriculture, Energy, and Society, Grades 10, 11, 12.  

ERIC Educational Resources Information Center

This interdisciplinary instructional unit contains eleven lessons for grades 10-12 which focus on the energy component of food production. There are lessons which contrast food production systems in various cultures and also lessons which look at different systems and techniques in use in this country. There are lessons dealing with organic…

Brock, Phyllis; And Others

20

Copper-Promoted Cyanation of a Boron Cluster: Synthesis, X-ray Structure, and Reactivity of 12-CN-closo-CHB11H10(-).  

PubMed

Microwave-assisted cross-coupling reactions of boron-iodinated derivatives of 1-carba-closo-dodecaborate(1-) (1) with CuCN is shown to cyanate boron vertices of this anion. Clusters with one or two CN groups can be prepared: syntheses of 12-CN-CHB11H10(-) (3) and 7,12-(CN)2-CHB11H9(-) (6) gave yields of 80% and 81%, respectively. The [Et4N](+) salts of 3 and 6 were characterized by NMR, IR, and mass spectroscopies, and the crystal structure of [Et4N]3 was determined by single-crystal X-ray diffraction. Hydrolysis of 3 gave the carboxylic acid 12-COOH-CHB11H10(-) (7). PMID:24050111

Rosenbaum, Aaron J; Juers, Douglas H; Juhasz, Marcus A

2013-09-19

21

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 1 ...  

Center for Biologics Evaluation and Research (CBER)

Text VersionPage 1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 1 FOOD AND DRUG ADMINISTRATION CENTER FOR ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

22

Ligations of N-acyl tryptophan units to give native peptides via 7-, 10-, 11- and 12-membered cyclic transition states.  

PubMed

N-Acyl tryptophan isopeptides undergo acyl transfer in chemical ligations via 7-, 10-, 11- and 12-membered cyclic transition states to yield natural peptides, representing the first examples of successful isopeptide ligations from N-acyl tryptophan units. PMID:23361377

Popov, Vadim; Panda, Siva S; Katritzky, Alan R

2013-02-13

23

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 ...  

Center for Biologics Evaluation and Research (CBER)

Text VersionPage 1. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 Page 401 to say our information is really poor, which ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

24

An endohedral metallofullerene as a pure electron donor: intramolecular electron transfer in donor-acceptor conjugates of La2@C80 and 11,11,12,12-tetracyano-9,10-anthra-p-quinodimethane (TCAQ).  

PubMed

An endohedral metallofullerene, La(2)@C(80), is covalently linked to the strong electron acceptor 11,11,12,12-tetracyano-9,10-anthra-p-quinodimethane (TCAQ) by means of the Prato reaction, affording two different [5,6]-metallofulleropyrrolidines, namely 1a and 2a. 1a and 2a were isolated and fully characterized by means of MALDI-TOF mass, UV-vis-NIR absorption, and NMR spectroscopies. In addition, cyclic voltammetry (CV) and differential pulse voltammetry (DPV) corroborated the unique redox character of 2a, that is, the presence of the electron-donating La(2)@C(80) and the electron-accepting TCAQ. Although a weak electronic coupling dictates the interactions between La(2)@C(80) and TCAQ in the ground state, time-resolved transient absorption experiments reveal that in the excited state (i.e., ?-?* centered at La(2)@C(80)) the unprecedented formation of the (La(2)@C(80))(•+)-(TCAQ)(•-) radical ion pair state evolves in nonpolar and polar media with a quantum efficiency of 33%. PMID:23116292

Takano, Yuta; Obuchi, Shota; Mizorogi, Naomi; García, Raúl; Herranz, M Ángeles; Rudolf, Marc; Guldi, Dirk M; Martín, Nazario; Nagase, Shigeru; Akasaka, Takeshi

2012-11-13

25

Efficient Synthesis of 12Aryl8,9,10,12-tetrahydrobenzo[a]xanthen-11-one Derivatives Catalyzed by p-Dodecylbenzenesulfonic Acid in Aqueous Media Under Ultrasound Irradiation  

Microsoft Academic Search

An efficient synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one derivatives via the three-component condensation of aromatic aldehyde, 2-naphthol, and 5,5-dimethyl-1,3-cyclohexanedione was carried out in 76–93% yields at 40–42 °C using p-dodecylbenzenesulfonic acid as catalyst in aqueous media under ultrasound irradiation.

Ji-Tai Li; Yan-Wei Li; Ya-Li Song

2012-01-01

26

Synthesis and structure of 9,10,11,12-Dibenz[a,c]-7,14-diaza-1,4-dioxacyclohexadecane-8,13-dione  

Microsoft Academic Search

The reaction of diphenic acid dioxatriethylenediimide with a methanolic solution of amines leads to splitting of the imide heterocyclic ring by methanol with the formation of the corresponding amidoester of diphenic acid. Amines catalyze this reaction. 9,10,11,12-Dibenz[a,c]-7,14-diaza-1,4-dioxahexadecane-8,13-dione was obtained from diphenoyl dichloride and the corresponding diamine. An x-ray diffraction study has been carried out

A. A. Dvorkin; É. V. Ganin; Yu. A. Simonov; G. S. Musienko; T. I. Malinovskii

1992-01-01

27

Conjugated Linoleic Acid Isomers, t 10 c 12 and c 9 t 11, are Differentially Incorporated into Adipose Tissue and Skeletal Muscle in Humans  

Microsoft Academic Search

Conjugated linoleic acid (CLA) is a popular supplement believed to enhance immune function, body composition and insulin sensitivity,\\u000a but results of scientific studies investigating its effects are conflicting. The isomer- and tissue-specific effects of CLA\\u000a may explain these conflicting results. Therefore, this study quantified the incorporation of the c9t11 and t10c12 CLA isomers into adipose tissue and skeletal muscle in

Julia H. GoedeckeDale; Dale E. Rae; Cornelius M. Smuts; Estelle V. Lambert; Marianne O’Shea

2009-01-01

28

Quantitative gas chromatographic method for the analysis of cis-9, trans-11 and trans-10, cis-12 isomers of the conjugated linoleic acid in liver  

Microsoft Academic Search

A quantitative GC method for conjugated linoleic acid (CLA) isomers of physiological significance (cis-9, trans-11 CLA and trans-10, cis-12 CLA) as non-esterified fatty acids (NEFA) or triacylglycerols (TAG) was developed. Furthermore, the effect of the internal standard addition point (sample or fat extract) was studied. Response linearity, recovery and precision assays, detection and quantification limits were determined. Linearity was demonstrated

A. Zabala; M. P. Portillo; V. Navarro; M. T. Macarulla; L. J. R. Barron; A. Fernández-Quintela

2007-01-01

29

Supernovae 2009gm-2009gs and Possible Supernovae K0905-10, K0905-11, K0905-12  

Microsoft Academic Search

Further magnitudes for K0905-12: May 13.37, [20.5 (CSS); June 2.20, g = 19.3, r = 19.3, i = 19.4 (Palomar); 17.18, 19.5 (CSS). D. Milisavljevic, R. Fesen, and J. Parrent, Dartmouth College, report that a low-dispersion spectrum (range 420-790 nm) of 2009gs, obtained on June 20.7 UT with the 2.4-m Hiltner telescope (+ CCDS) at MDM Observatory, shows it to

D. Milisavljevic; R. Fesen; J. Parrent

2009-01-01

30

Association of IL-12p70 and IL-6:IL-10 ratio with autism-related behaviors in 22q11.2 deletion syndrome: a preliminary report.  

PubMed

22q11.2 deletion syndrome (22q11DS) is a genetic disorder that conveys a significant risk for the development of social behavior disorders, including autism and schizophrenia. Also known as DiGeorge syndrome, 22q11DS is the second most common genetic disorder and is characterized by an elevated risk for immune dysfunction, up to 77% of individuals have an identifiable immune deficiency. We hypothesize that this immune dysfunction could contribute to the elevated risk of impaired social behavior seen in 22q11DS. The current study begins to elucidate these immune deficits and link them with the behavioral alterations associated with the disorder. Serum concentrations of a series of cytokines were examined, using a multiplex immunoassay, in sixteen individuals with 22q11DS and screened for autism-related behavior using the Autism Diagnostic Interview-Revised (ADI-R). This preliminary study examined correlations between specific immune proteins and each of the ADI-R algorithm scores (social, communication, and repetitive behavior). The inflammatory cytokine IL-1?, as well as the ratio between the inflammatory cytokine IL-6 and the anti-inflammatory cytokine IL-10, were correlated with social scores (r=0.851, p=0.004; r=0.580, p=0.018). In addition, the inflammatory cytokines interferon gamma and IL-12p70 were correlated with repetitive behaviors (r=0.795, p=0.033; r=0.774, p=0.002). Interestingly, IL-12 has been reported to be increased in autistic children. These data show a positive association between severity of autism-related behaviors and level of serum concentrations of inflammatory cytokines in individuals with 22q11DS, providing a basis for further inquiry. PMID:23353117

Ross, Heather E; Guo, Ying; Coleman, Karlene; Ousley, Opal; Miller, Andrew H

2013-01-24

31

Heat of Mixing and Solution of Propyl benzoate C10H12O2 + C11H24 Undecane (HMSD1111, LB4170_H)  

NASA Astrophysics Data System (ADS)

This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Heat of Mixing and Solution of Propyl benzoate C10H12O2 + C11H24 Undecane (HMSD1111, LB4170_H)' providing data from direct low-pressure calorimetric measurement of molar excess enthalpy at variable mole fraction and constant temperature.

Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

32

Efficient Synthesis of 12-aryl -8,9,10,12-tetrahydrobenzo[A]xanthen-11-one Derivatives Catalyzed by p-dodecylbenzenesulfonic Acid in Aqueous Media Under Ultrasound Irradiation  

Microsoft Academic Search

An efficient synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one derivatives via the three-component condensation of aromatic aldehyde, 2-naphthol and 5,5-dimethyl-1,3-cyclohexanedione was carried out in 76-93% yields at 40-42 °C using p-dodecylbenzenesulfonic acid (DBSA) as catalyst in aqueous media under ultrasound irradiation.

Ji-Tai Li; Yan-Wei Li; Ya-Li Song

2012-01-01

33

10 CFR 11.11 - General requirements.  

Code of Federal Regulations, 2013 CFR

...FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...Requirements for Special Nuclear Material Access Authorization § 11.11 General...NRC-U special nuclear material access authorization, or by...

2013-01-01

34

Toxicity of C{sub 10}-, C{sub 11}-, C{sub 12}-, and C{sub 14}-polychlorinated alkanes to Japanese medaka (Oryzias latipes) embryos  

SciTech Connect

Japanese medaka (Oryzias latipes) eggs were exposed to aqueous concentrations of six polychlorinated n-alkane (PCA) standards (C{sub 10}H{sub 15.5}Cl{sub 6.5}, C{sub 10}H{sub 15.3}Cl{sub 6.7}, C{sub 11}H{sub 18.4}Cl{sub 5.6}, C{sub 12}H{sub 19.5}Cl{sub 6.5}, C{sub 14}H{sub 24.9}Cl{sub 5.1}, and C{sub 14}H{sub 23.3}Cl{sub 6.7}) of known carbon chain length and chlorine content to assess their toxicity. Eggs were also exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to act as a positive control. Chlorinated paraffins are complex industrial products for which there is a lack of toxicological data on individual congeners. High aqueous concentrations of C{sub 10}H{sub 15.5}Cl{sub 6.5} and C{sub 10}H{sub 15.3}Cl{sub 6.7} caused 100% mortality in eggs, but no other significant mortalities or lesions were observed at lower concentrations or in any eggs exposed to the other PCAs. Larvae from eggs exposed to high concentrations of the C{sub 10}-, C{sup 11}- and C{sub 12}-PCAs were extremely lethargic or did not move, although a heart beat was present. The concentrations in these exposures and the tissue concentrations of the larvae were at levels that should elicit narcosis. Concentrations of the C{sub 14}-PCAs in larvae did not reach narcotic levels, and larvae in these exposures appeared normal with no signs of narcosis. The TCDD was found to be extremely embryotoxic, consistent with past work using Japanese medaka eggs. The ratio of LC50 to TCDD to the LC50 of the PCAs, based on acute toxicity and TCDD results, were all <0.0001, and most were <0.000001. These results suggest that the acute mechanism of toxicity of lower chlorinated, short (C{sub 10--13}) and medium (C{sub 14--18}) carbon chain PCAs is narcosis and that chlorine substitution on the terminal carbons of PCAs does not significantly increase nor decrease the toxicity of C{sub 10} and C{sub 14}-PCAs. However, additional work is needed to assess a greater range of PCAs as well as their sublethal effects and chronic toxicity.

Fisk, A.T.; Tomy, G.T.; Muir, D.C.G.

1999-12-01

35

Spectroscopic characterizations and comparisons of the structures of the covalent adducts derived from the reactions 7,8-dihydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene and 9,10,11,12-tetrahydrobenzo(e)pyrene with DNA  

Microsoft Academic Search

The conformation of covalent adducts derived from the reactions of racemic 7..beta..,8..cap alpha..-dihydroxy-9..cap alpha..,10..cap alpha..-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BaPDE), 9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BaPE), and 9,10-epoxy-9,10,11,12-tetrahydrobenzo(e)pyrene (BePE) with calf thymus DNA in aqueous buffer solution (25°C, pH 7.0) were investigated and compared by means of absorption, fluorescence and electric linear dichroism techniques. Two types of conformations are recognized. Site I is characterized by a red shift

N. E. Geacintov; A. G. Gagliano; V. Ibanez; R. G. Harvey

1982-01-01

36

A 10.46 Mb 12p11.1-12.1 interstitial deletion coincident with a 0.19 Mb NRXN1 deletion detected by array CGH in a girl with scoliosis and autism.  

PubMed

We present a 12-year-old girl with de novo karyotype 46,XX,del(12)(p11.1p12.1). Array CGH revealed in addition to a 10.466 Mb interstitial deletion on 12p11.1?12p12.1 a 0.191 Mb deletion on 2p16.3. The girl presented with mild facial dysmorphism consisting of microcephaly, hypertelorism, downslanting palpebral fissures, strabismus, broad nasal base, bulbous nose, short philtrum, micro/retrognathia, irregular tooth arrangement, phalangeal deformity in distal phalanges of hands, 5th finger camptodactyly, brachydactyly in feet, history of joint hypermobility, and scoliosis. She was considered to have mild to moderate mental retardation and ascertained for an autism spectrum disorder(ASD). Short arm of chromosome 12 interstitial deletions are rarely reported whereas point mutations and deletions of NRXN1, which is located on chromosome 2p16.3, are associated with ASDs. In this article we present and discuss the phenotypic consequences of a patient who was affected by deletions of two different chromosomal regions. PMID:21626680

Soysal, Yasemin; Vermeesch, Joris; Davani, Nooshin Ardeshir; Hekimler, Kuya?; Imirzalio?lu, Necat

2011-05-27

37

Weiherweg 5.41 6.01 6.14 6.29 6.44 6.59 7.14 7.29 7.44 7.59 8.14 8.29 8.44 9.07 9.17 9.37 9.47 10.07 10.17 10.37 10.47 11.07 11.17 11.37 11.47 12.07 - Peierlhang 5.41 6.01 6.14 6.29 6.44 6.59 7.14 7.29 7.44 7.59 8.14 8.29 8.44 9.07 9.17 9.37 9.47 10.07 10.17 10.37 10.47 11.07 11.17 11.37 11.47 12.07  

Microsoft Academic Search

- Toni-Schruf-Weg 5.40 6.00 6.16 6.26 6.36 6.56 7.06 7.16 7.36 7.46 8.06 8.16 8.36 8.46 9.06 9.16 9.36 9.46 10.06 10.16 10.36 10.46 11.06 11.16 11.36 11.46 - Weiherweg 5.41 6.01 6.17 6.27 6.37 6.57 7.07 7.17 7.37 7.47 8.07 8.17 8.37 8.47 9.07 9.17 9.37 9.47 10.07 10.17 10.37 10.47 11.07 11.17 11.37 11.47 - Peierlhang 5.41 6.01

Graz Jakominiplatz; Graz Petri Au

38

IUPAC-NIST Solubility Data Series. 81. Hydrocarbons with Water and Seawater—Revised and Updated. Part 10. C11 and C12 Hydrocarbons with Water  

Microsoft Academic Search

The mutual solubilities and related liquid–liquid equilibria of C11 and C12 hydrocarbons with water and heavy water are exhaustively and critically reviewed. Reports of experimental determination of solubility in 24 chemically distinct binary systems that appeared in the primary literature prior to end of 2002 are compiled. For 12 systems sufficient data are available to allow critical evaluation. All data

David G. Shaw; Andrzej Maczynski; Marian Goral; Barbara Wisniewska-Goclowska; Adam Skrzecz; Iwona Owczarek; Krystyna Blazej; Marie-Claire Haulait-Pirson; Glenn T. Hefter; F. Kapuku; Zofia Maczynska; Andrzej Szafranski

2006-01-01

39

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 ...  

Center for Biologics Evaluation and Research (CBER)

Text Version... little bit earlier. ... 4 184:21 201:1 112:21 139:6 emergency 220:10 English 34:3 77:5 ... downs100:11 ducked 72:19 195:11 196:7 168:9 217:1,15 218:13 ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

40

The ?4, ?9, ?10 and ?6+?11 bands of 13CH3-12CH3 between 1245 and 1550 cm-1  

NASA Astrophysics Data System (ADS)

To support atmospheric studies of the Jovian planets, the infrared spectrum of 13CH3-12CH3 was measured between 1245 and 1550 cm-1. Using a 99% 13C-enriched ethane sample, spectra were recorded at 0.0022 cm-1 resolution with the 125 HR Bruker FTIR configured to a temperature-controlled absorption cell of 0.204 m path length cooled to 130.3 K. From these, we obtained the first analysis of isotopic ethane for the three fundamentals (v4, v9 and v10) and one combination band (v6+v11). The spectrum itself is very complex; while torsional splitting produces two components (as in normal ethane), there are additional small splittings in both v9 and v10 wherever the normally infrared inactive v10 levels are perturbed by interaction with nearby states of v9. The spectrum was assigned and analyzed by adopting an appropriate Hamiltonian model; vibration-rotation-torsion parameters of these four bands were determined by the least squares process to model 1348 observed line positions with an RMS deviation of 3.24×10-3 cm-1. The values of rotational and torsional parameters of the vibrational ground state were also improved or determined using the new cold spectrum. The parallel band v4 has very perturbed intensity patterns (e. g. with the R-transitions markedly stronger than the P-transitions) due to its Coriolis coupling with v9, and future analysis of the intensities is needed to obtain reliable predictions of this spectrum. For the interim, an empirical linelist is being formed by combining measured positions and intensities at 130 K with lower state energies from known quantum assignments so that lines of this molecule can be identified in planetary spectra. Part of the research described in this paper was performed at the Jet Propulsion Laboratory, California Institute of Technology, Connecticut College, and NASA Langley under contract with the National Aeronautics and Space Administration.

Brown, Linda R.; di Lauro, C.; Lattanzi, F.; Mantz, A. W.; Smith, M. H.

2013-10-01

41

50 CFR 12.11 - Notification of seizure.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 false Notification of seizure. 12.11 Section 12.11 Wildlife...AND IMPORTATION OF WILDLIFE AND PLANTS SEIZURE AND FORFEITURE PROCEDURES Preliminary Requirements § 12.11 Notification of seizure. Except where the owner or...

2012-10-01

42

50 CFR 12.11 - Notification of seizure.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 false Notification of seizure. 12.11 Section 12.11 Wildlife...AND IMPORTATION OF WILDLIFE AND PLANTS SEIZURE AND FORFEITURE PROCEDURES Preliminary Requirements § 12.11 Notification of seizure. Except where the owner or...

2011-10-01

43

Fully relativistic rovibrational energies and spectroscopic constants of the lowest X:(1)0(+)g, A':(1)2( u ), A:(1)1 ( u ), B':(1)0(-)u and B:(1)0(+)u states of molecular chlorine.  

PubMed

The main goal of this paper is to present the rovibrational energies and spectroscopic constants of the Cl(2) molecular system in the relativistic states [Formula: see text], A':(1)2( u ), A:(1)1( u ), [Formula: see text] and [Formula: see text]. More precisely, we have evaluated the Cl(2) ? ( e ), ? ( e ) x ( e ), ? ( e ) y ( e ), ? ( e ), ? ( e ) and B ( e ) rovibrational spectroscopic constants using two different procedures. The first was obtained by combining the rovibrational energies, calculated through solving Schrödinger's nuclear equation and the diatomic rovibrational energy equation. The second was obtained by using the Dunham method. The calculated properties are in good agreement with available experimental data. PMID:22581059

Machado, Daniel F S; Silva, Valter H C; Esteves, Cristiano S; Gargano, Ricardo; Macedo, Luiz G M; Mundim, Kleber C; de Oliveira, Heibbe C B

2012-05-12

44

De Par en Par, 10 & 11. (Wide Open, 10 & 11.)  

ERIC Educational Resources Information Center

These two magazines, written entirely in Spanish, are designed for classroom use in the elementary grades. Number 10, focuses on ecology, discussing such topics as the greenhouse effect, endangered species, protecting the natural environment, tree planting, earthworms, natural waste, books on environmental subjects, saving the earth, and…

De Par en Par, 1997

1997-01-01

45

De Par en Par, 10 & 11. (Wide Open, 10 & 11.)  

ERIC Educational Resources Information Center

|These two magazines, written entirely in Spanish, are designed for classroom use in the elementary grades. Number 10, focuses on ecology, discussing such topics as the greenhouse effect, endangered species, protecting the natural environment, tree planting, earthworms, natural waste, books on environmental subjects, saving the earth, and…

De Par en Par, 1997

1997-01-01

46

Theoretical study of H sub 2 elimination from B sub 4 H sub 10 , B sub 5 H sub 11 , and B sub 6 H sub 12 and BH sub 3 elimination from B sub 4 H sub 10  

SciTech Connect

Ab initio calculations are employed to evaluate decomposition pathways of several boron hydrides. Reactants, products, and transition states for the decomposition of B{sub 4}H{sub 10} were optimized at the MP2/6-31G* level. The predicted barrier for formation of B{sub 4}H{sub 8} + H{sub 2} is in good agreement with experiment (26.8 (calcd) and 23.7 (exptl) kcal/mol) while the barrier for formation of B{sub 3}H{sub 7} + BH{sub 3} is 13.7 kcal/mol higher. Loss of H{sub 2} from B{sub 5}H{sub 11} and B{sub 6}H{sub 12} is predicted to occur with activation barriers of 52.8 and 37.4 kcal/mol, respectively (MP2/6-31G*//3-21G). The most significant discovery is that the observed decomposition of B{sub 5}H{sub 11} cannot occur as previously thought by the reaction B{sub 5}H{sub 11} {yields} B{sub 4}H{sub 8} + BH{sub 3} since this reaction has a calculated endothermicity 18.1 kcal/mol greater than the observed activation barrier.

McKee, M.L. (Auburn Univ., AL (USA))

1990-09-12

48

12 CFR 1301.11 - Administrative appeals.  

Code of Federal Regulations, 2013 CFR

12 Banks and Banking 9 2013-01-01 2013-01-01...11 Section 1301.11 Banks and Banking FINANCIAL STABILITY OVERSIGHT COUNCIL FREEDOM...Information Act Appealâ and addressed to Financial Stability Oversight Council,...

2013-01-01

49

Consumption of c 9, t 11–18:2 or t 10, c 12–18:2 Enriched Dietary Supplements Does Not Influence Milk Macronutrients in Healthy, Lactating Women  

Microsoft Academic Search

Substantial research suggests that the t10,c12–18:2, but not the c9,t11–18:2, isomer of conjugated linoleic acid (CLA) reduces milk fat synthesis in lactating bovine and rodent species. Because\\u000a fat is the major energy-yielding component in human milk, we were interested in whether this is true for women as well. Thus,\\u000a the effects of c9,t11–18:2 and t10,c12–18:2 on milk fat were examined

Afroza Hasin; J. Mikko Griinari; Janet E. Williams; Alam M. Shahin; Mark A. McGuire; Michelle K. McGuire

2007-01-01

50

Effects of the individual isomers cis -9, trans -11 vs. trans -10, cis -12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL-phenotype B  

Microsoft Academic Search

Immune-modulating effects of CLA have been reported in animals, but results are inconsistent. In humans, CLA has shown no\\u000a effects or only minor effects on immune function. The objective of this study was to evaluate the immune-modulating effects\\u000a of 3 g cis-9,trans-11 (c9,t11) vs. trans-10,cis-12 (t10,c12) CLA isomers in a population with a high risk of coronary heart disease characterized

Julian D. Ramakers; Jogchum Plat; Jean-Louis Sébédio; Ronald P. Mensink

2005-01-01

51

Syntheses of anti-7,8,9,10-Tetrahydro-11-, and 12-Methylbenzo[A]Pyrene7,8DIOL9, 10-Epoxides: Identification and Comparison of DNA Adduct Formation with Calf-Thymus DNA in vitro  

Microsoft Academic Search

The presence of a methyl group in the bay region adjacent to an angular ring enhances the carcinogenicity of many PAH compounds in contrast to structural analogues lacking this feature. For example, on mouse skin 5-methylchrysene is more carcinogenic than all other monomethylchrysenes or chrysene itself; 11-methylbenzo[a]pyrene is more tumorigenic than other monomethylbenzo[a]pyrenes or benzo[a]pyrene itself. anti-7,8,9,10-Tetrahydro-11-methylbenzo[a]pyrene-7,8-diol-9, 10-epoxide (11-MeBPDE) is

Jyh-ming Lin; Dhimant Desai; Lehua Chung; Stephen S. Hecht; Shantu Amin

1999-01-01

52

12 CFR 1282.11 - General.  

Code of Federal Regulations, 2012 CFR

...HOUSING FINANCE AGENCY HOUSING GOALS AND MISSION ENTERPRISE HOUSING GOALS AND MISSION Housing Goals § 1282.11 General. (a) General. Pursuant to the requirements of the Safety and Soundness Act (12...

2012-01-01

53

10. SAME DETAIL AS ABOVE, WITH SHUTTER FULLY CLOSED 11. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. SAME DETAIL AS ABOVE, WITH SHUTTER FULLY CLOSED 11. 'SHIP ROOM,' SECOND FLOOR, LOOKING NORTHWEST 12. 'SHIP ROOM,' SECOND FLOOR, LOOKING NORTH - Friends Meeting House, 30 Farewell Street, Newport, Newport County, RI

54

46 CFR 90.10-11 - Coastwise.  

Code of Federal Regulations, 2010 CFR

[Title 46 CFR 90.10-11] [Code of Federal Regulations (annual edition) - October 1, 1996 Edition] [Title 46 - SHIPPING] [Chapter I - COAST GUARD, DEPARTMENT OF] [Subchapter I - CARGO AND MISCELLANEOUS VESSELS] [Part 90 - GENERAL PROVISIONS] [Subpart...

1996-10-01

55

Double differential neutron emission cross sections of /sup 10/B and /sup 11/B at 6, 10 and 14 MeV and of /sup 6/Li, /sup 7/Li and /sup 12/C at 14 MeV  

SciTech Connect

Neutron emission spectra of /sup 10/B and /sup 11/B were measured at 6, 10, and 14.1 MeV and those of /sup 6/Li, /sup 7/Li and carbon at 14.1 MeV using time-of-flight technique. Absolute double differential cross sections were obtained by using scattering from hydrogen as a cross section reference. Integration over energy ranges and solid angle yielded integrated elastic and total neutron emission cross sections. At 6 and 10 MeV excellent agreement with total cross section data is found, at 14.1 MeV the new data tend to be higher than expected. The biggest error source in the continuous spectra stems from uncertainties in the input library (ENDF/B-IV) of the Monte Carlo correction for multiple scattering. In particular, the library for /sup 11/B appears to be very unrealistic, with a total elastic cross section at 14.1 MeV which should be higher by 50%.

Drosg, M.; Lisowski, P.W.; Hardekopf, R.A.; Drake, D.M.; Treitl, K.

1985-01-01

56

Synthesis of gem-dideuterated tetradecanoic acids and their use in investigating the enzymatic transformation of (Z)-11-tetradecenoic acid into (E,E)-10,12-tetradecadienoic acid.  

PubMed

We report the preparation of the deuterated tetradecanoic acids [2,2,3,3-(2)H(4)]-, [2,2,3,3,10,10-(2)H(6)]-, and [2,2,3,3,13,13-(2)H(6)]-tetradecanoic acids (1, 2, and 3, respectively) and their use to investigate the mechanism of the enzymatic transformation of (Z)-11-tetradecenoic acid into (E,E)-10,12-tetradecadienoic acid. Probes 2 and 3 were prepared from intermediate ketones 7 and 10, which were transformed into the labeled bromides 17 and 18 by reduction with NaBD(4), tosylation of the resulting alcohol, replacement of the tosyloxy group by deuteride with LiAlD(4), hydrolysis, and reaction with N-bromosuccinimide. The resulting bromides were converted into the alpha-acetylenic esters 21 and 22, respectively, and the additional deuterium labels were introduced by reduction of the conjugated triple bond with Mg in deuterated methanol. The same sequence of reactions starting with 11-bromoundecane afforded 27. Saponification of the labeled esters 23, 24, and 27 gave the deuterated acids 2, 3, and 1, respectively. The results of the biochemical experiments showed that C10-H removal, but not elimination of C13-H, was sensitive to deuterium substitution in the transformation of (Z)-11-tetradecenoic acid into (E,E)-10,12-tetradecadienoic acid, which is consistent with the hypothesis that this desaturase reaction involves a first slow, C10-H bond cleavage, with probable formation of an unstable allylic intermediate, followed by a second fast C13-H bond removal and concomitant rearrangement. PMID:11722204

Rodríguez, S; Camps, F; Fabriàs, G

2001-11-30

57

Family Studies 10-12.  

ERIC Educational Resources Information Center

This curriculum guide became official in September 1989, and is one of three composing the senior high home economics curriculum in Canada. It includes 9 major concepts for grade 10: caregiving, careers and volunteer activities related to children, studying children, fundamentals of development, prenatal development, birth, the infant, the…

Manitoba Dept. of Education, Winnipeg.

58

Family Studies 10-12.  

ERIC Educational Resources Information Center

|This curriculum guide became official in September 1989, and is one of three composing the senior high home economics curriculum in Canada. It includes 9 major concepts for grade 10: caregiving, careers and volunteer activities related to children, studying children, fundamentals of development, prenatal development, birth, the infant, the…

Manitoba Dept. of Education, Winnipeg.

59

43 CFR 11.12 - Biennial review of regulations.  

Code of Federal Regulations, 2011 CFR

...of regulations. 11.12 Section 11.12 Public Lands: Interior Office of the Secretary of the Interior NATURAL RESOURCE DAMAGE ASSESSMENTS Introduction § 11.12 Biennial review of regulations. The regulations and...

2011-10-01

60

43 CFR 11.12 - Biennial review of regulations.  

Code of Federal Regulations, 2012 CFR

...of regulations. 11.12 Section 11.12 Public Lands: Interior Office of the Secretary of the Interior NATURAL RESOURCE DAMAGE ASSESSMENTS Introduction § 11.12 Biennial review of regulations. The regulations and...

2012-10-01

61

46 CFR 111.12-11 - Generator protection.  

Code of Federal Regulations, 2012 CFR

...12-11 Section 111.12-11 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Generator Construction and Circuits § 111.12-11...

2012-10-01

62

Supplies tight for CFC-11 and -12  

SciTech Connect

With US 1992 production of chlorofluorocarbon (CFC)-11 and -12 cut back to less than 50% of 1986 levels, supplies are tight and prices are rising. While CFC customers can find the product, the first half of the year was particularly bumpy, marked by shortages of key feedstock carbon tetrachloride. US carbon tet production dropped from 400 million lbs in 1991 to 250 million lbs because of a series of plant closings in 1991. The lack of carbon tet, says a spokesman for one CFC producer, was [open quotes]a real disruption.[close quotes] And, says Jerry Dziedzic, general manager, fluorochemicals at Elf Atochem (Philadelphia), in a such a tight market [open quotes]even a little hiccup can throw the system out of whack.[close quotes] Dow senior project manager Jeff Sullivan says CFC producers were expecting a drop in 1992 sales when the company's Sarnia, ON carbon tet plant closing was announced. By the time CFC producers recognized that demand would remain at 1991 levels, the shutdown was under way. [open quotes]We were caught short because they were caught short.[close quotes] While the carbon tet shortage has lessened recently, supplies of CFC-11 and 12 are expected to remain tight through the rest of the year. But that could ease toward year-end as hydrofluorocarbon-141b increasingly replaces CFC-11.

Rotman, D.; Kirschner, E.

1992-09-30

63

Lifshitz solutions of D=10 and D=11 supergravity  

NASA Astrophysics Data System (ADS)

We construct infinite families of Lifshitz solutions of D = 10 and D = 11 supergravity with dynamical exponent z = 2. The new solutions are based on five-and seven-dimensional Einstein manifolds and are dual to field theories with Lifshitz scaling in 1+2 and 1+1 spacetime dimensions, respectively. When the Einstein spaces are Sasaki-Einstein, the solutions are supersymmetric.

Donos, Aristomenis; Gauntlett, Jerome P.

2010-12-01

64

10 CFR 10.12 - Interview and other investigation.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Interview and other investigation. 10.12...an Employment Clearance § 10.12 Interview and other investigation. (a...possession of the NRC or may authorize an interview with the individual, if the...

2013-01-01

65

10 CFR 470.11 - Eligibility requirements.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Eligibility requirements. 470.11 Section 470.11 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION APPROPRIATE TECHNOLOGY SMALL GRANTS PROGRAM § 470.11 Eligibility requirements. (a)...

2013-01-01

66

12 CFR 508.11 - Relevant considerations.  

Code of Federal Regulations, 2013 CFR

... Banks and Banking 6 2013-01-01 2012-01-01 true Relevant considerations. 508.11 Section 508.11 ...TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.11 Relevant...

2013-01-01

67

Synthesis of (11,11,12,12-2H4)progesterone for mass spectral investigations of peripheral metabolism  

SciTech Connect

Hecogenin has been transformed into (11,11,12,12-2H4)progesterone via base-catalyzed isotope exchange with D2O (at C-11), carbenic decomposition of the 12-tosylhydrazone formed by the use of (N,N,N'-2H3)toluene-p-sulfonylhydrazine, and reduction with (2H2)diimide to give (11,11,12,12-2H4)tigogenin, followed by standard degradation of the spiroketal side chain and dehydrogenation in ring A.

Kirk, D.N.; Smith, C.Z.; Honour, J.W. (Queen Mary College, London (England))

1990-05-01

68

Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid, linoleic acid, phytanic acid and the combination of various fatty acids on proliferation and cytokine expression of bovine peripheral blood mononuclear cells.  

PubMed

Fatty acids may have an impact on immune functions, which is important in times of increased mobilization of body fat, e.g., around parturition. The aim of the present study was to investigate the effects of the CLA isomers cis-9,trans-11 and trans-10,cis-12, phytanic acid (PA), linoleic acid (LA) and a fatty acid (FA) mixture (containing 29.8% palmitic acid, 6.7% palmitoleic acid, 17.4% stearic acid and 46.1% oleic acid) on the proliferation of bovine blood mononuclear cells (PBMC) in vitro using alamar blue (AB) and 5-bromo-2'-deoxyuridine (BrdU) assay. Quantitative real time polymerase chain reaction analyses were performed to evaluate the expression of interleukin (IL)-4, IL-10, interferon (IFN)-?, tumor necrosis factor (TNF)-? and peroxisome proliferator-activated receptor (PPAR)-? in response to cis-9,trans-11 and LA. The IC50 values did not differ between the investigated FA, but there were differences within the proliferation in the response of these FA in a concentration range between 20 and 148 µM (e.g., increased proliferation after treatment with lower concentrations of LA). No differences occurred when different FA combinations were tested. ConA stimulation increased the expression of TNF-? and IFN-?, whereas IL-10 decreased. In general, neither the baseline expression nor the ConA-stimulated mRNA expression of cytokines and PPAR-? were affected by the FA. In conclusion, all FA inhibit the proliferation of PBMC dose dependently without significantly altering the induced cytokine spectrum of activated bovine PBMC. PMID:23857174

Renner, Lydia; Kersten, Susanne; Duevel, Anna; Schuberth, Hans-Joachim; Dänicke, Sven

2013-07-12

69

10 CFR 11.32 - Criminal penalties.  

Code of Federal Regulations, 2013 CFR

...Section 11.32 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL Violations § 11.32 Criminal penalties. (a) Section 223 of...

2013-01-01

70

10 CFR 11.3 - Scope.  

Code of Federal Regulations, 2013 CFR

...DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...11 or § 11.13 requiring access to, or control over, formula quantities...criteria, or procedures for access to or control over classified special...

2013-01-01

71

10 CFR 11.30 - Violations.  

Code of Federal Regulations, 2013 CFR

...Section 11.30 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL Violations § 11.30 Violations. (a) The Commission may obtain an...

2013-01-01

72

10 CFR 11.9 - Specific exemptions.  

Code of Federal Regulations, 2013 CFR

...Section 11.9 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL General Provisions § 11.9 Specific exemptions. The...

2013-01-01

73

(2R*,4R*,7S*,10R*,12R*)-3,11,13,15-Tetra-oxa-penta-cyclo-[5.5.3.01,7.02,4.010,12]penta-deca-5,8-dien-14-one  

PubMed Central

The title compound, C11H8O5, features a ‘skipped’ diene, an anti-bis­(epoxide) and a cyclic carbonate, all embedded in a densely functionalized [4.4.3]propellane scaffold. The crystal packing of this diepoxide is effected primarily by C—H?O hydrogen bonds, which link the mol­ecules into tapes along the b axis. Inter-tape connectivity is brought about by centrosymmetrically disposed pairs of C?O contacts [3.183?(4)?Å] between the C?+=O?- dipoles of neighbouring carbonate moieties.

Mehta, Goverdhan; Sen, Saikat; Kumar, C. S. Ananda

2013-01-01

74

10 CFR 150.11 - Critical mass.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Critical mass. 150.11 Section 150.11 Energy...Agreement States § 150.11 Critical mass. (a) For the purposes of this part...quantities not sufficient to form a critical mass means uranium enriched in...

2013-01-01

75

12 CFR 622.11 - Motions.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Motions. 622.11 Section 622.11 Banks...Applicable to Formal Hearings § 622.11 Motions. (a) How made. An application...during a hearing, shall be made by written motion supported by a memorandum which...

2013-01-01

76

12 CFR 1403.11 - Criminal penalties.  

Code of Federal Regulations, 2012 CFR

...and Banking 9 2012-01-01 2012-01-01 false Criminal penalties. 1403.11 Section 1403.11 Banks and Banking...INSURANCE CORPORATION PRIVACY ACT REGULATIONS § 1403.11 Criminal penalties. Section 552a(i)(3) of the Privacy...

2012-01-01

77

12-(4-Methoxy-phen-yl)-10-phenyl-3,4,5,6,8,10-hexa-azatricyclo-[7.3.0.02,6]dodeca-1(9),2,4,7,11-penta-ene  

PubMed Central

In the title compound, C19H14N6O, the fused 12-membered tetra­zolo/pyrimidine/pyrrole ring system is almost planar (r.m.s. deviation = 0.013?Å). The 4-methoxy­phenyl and phenyl substituents on the pyrrole ring are both twisted with respect to the fused-ring system [dihedral angles = 25.39?(18) and 36.42?(18)°, respectively]. Intra­molecular C—H?N inter­actions occur. In the crystal, mol­ecules pack into layers in the ac plane and these are connected along the b axis via C—H?? and ?–? [centroid–centroid separation = 3.608?(3)?Å] inter­actions.

Jotani, Mukesh M.; Shah, Rina D.; Tiekink, Edward R. T.

2010-01-01

78

12-(4-Chloro-phen-yl)-7-methyl-10-phenyl-3,4,5,6,8,10-hexa-aza-tricyclo-[7.3.0.02,6]dodeca-1(9),2,4,7,11-penta-ene  

PubMed Central

The 12 non-H atoms defining the triple-fused-ring system in the title compound, C19H13ClN6, are almost coplanar (r.m.s. deviation = 0.023?Å). The chloro-substituted ring is almost effectively coplanar with the central atoms [dihedral angle = 6.74?(13)°], but the N-bound benzene ring is not [dihedral angle = 54.38?(13)°]. In the crystal, supra­molecular chains along the a axis sustained by C—H?? and ?–? [centroid–centroid distance between N4C and C4N five-membered rings = 3.484?(2)?Å] stacking occur. A very long C—Cl?? contact is also seen.

Shah, Rina D.; Jotani, Mukesh M.; Tiekink, Edward R. T.

2010-01-01

79

tert-Butyl (2R,4aR,5aR,11aS,12R,12aR)-8-[bis-(tert-but-oxycarbon-yl)amino]-12-hydroxy-2-meth-oxy-2,10-dioxo-4,4a,5a,6,9,10,11,11a,12,12a-deca-hydro-2H-1,3,5-trioxa-6,7,9,11-tetra-aza-2?5-phosphatetra-cene-6-carboxyl-ate methanol monosolvate monohydrate  

PubMed Central

The title compound, C26H40N5O13P·CH3OH·H2O, crystallizes with one water and one methanol mol­ecule providing important crystal-binding inter­actions. The compound has the unusual feature of having two but­oxy­carbonyl groups bound to one N atom. The conventional attractive hydrogen bonds involving hy­droxy, amine and water donors include bifurcations at both donors and acceptors with novel R 1 2(6) and R 2 1(6) motifs. These are supplemented by C—H?O inter­actions between adjacent mol­ecules forming chain and R 2 2(10) ring motifs.

Gainsford, Graeme J.; Clinch, Keith; Dixon, Rachel; Tiwari, Ashish

2012-01-01

80

10 CFR 440.11 - Native Americans.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Native Americans. 440.11 Section 440...LOW-INCOME PERSONS § 440.11 Native Americans. (a) Notwithstanding...population of all low-income Native Americans for whom a determination...

2013-01-01

81

Synthesis of progesterone-11, 11, 12, 12-d/sub 4/  

SciTech Connect

A variant of the Huang-Minlon reduction of keto steroids was developed in this article. In it, the alpha-hydrogen atoms and the carbonyl oxygen were replaced by the corresponding numbers of deuterium atoms with the use of deuterium oxide as the sole primary source of the isotope. An investigation was made of the introduction of a 4,5-double bond into 5alpha-pregnane-3,20-dione by 2-bromination, the conversion of the product into the corresponding pyridinium salt, and its pyrolysis; the overall yield of progesterone was raised to 46%. With the use of the methods described, from gekogenin acetate the authors synthesized progesterone-11,11,12,12-d/sub 4/ of high isotopic purity, suitable for use as internal standard in chromato-mass-fragmentography.

Golubovskaya, L.E.; Pivnitskii, K.K.

1985-08-01

82

1-Phenyl-1,2-dicarba-closo-dodecaborane, 1-Ph-1,2-closo-C(2)B(10)H(11). Synthesis, Characterization, and Structure As Determined in the Gas Phase by Electron Diffraction, in the Crystalline Phase at 199 K by X-ray Diffraction, and by ab Initio Computations.  

PubMed

The compound 1-phenyl-1,2-dicarba-closo-dodecaborane(12), 1-C(6)H(5)-1,2-closo-C(2)B(10)H(11) (1), has been synthesized and characterized by a complete assignment of its (11)B NMR spectrum via (11)B{(1)H}/(11)B{(1)H} (COSY), (1)H{(11)B(selective)} and (1)H{(11)B}/(1)H{(11)B} (COSY) spectroscopy. An electron- and X-ray diffraction investigation of 1, complemented by ab initio calculations, has been undertaken. The gas-phase electron-diffraction (GED) data can be fitted by several models describing conformations which differ in the position of the phenyl ring with respect to the carborane cage. Local symmetries ofC(2)(v)() and D(6)(h)() for the 1,2-C(2)B(10) and C(6) moieties, respectively, were adopted in the GED model in order to simplify the problem. In addition, constraints among the close-lying C-C and B-B bonds were employed. However, even though such simplifications led to satisfactory refinements (R(G) = 0.069-0.071), a unique, definitive solution could not be gained. The (C-C)(mean), (C-B)(mean) and (B-B)(mean) bond lengths,r(a), are ca. 1.44, 1.72, and 1.78 Å, respectively. The C(6) hexagon, with r(a)(C-C) = ca. 1.394 Å, either eclipses the C(1)-C(2) vector (overall C(s)() symmetry) or more or less eclipses the C(1)-B(4) cluster bond (overall C(1) symmetry). In contrast, in the solid at 199 K, the ring lies at a position intermediate between the two GED positions, as determined by X-ray crystallography [C(8)H(16)B(10), monoclinic P2(1)/a: a = 12.047(3) Å, b = 18.627(4) Å, c = 12.332(5) Å, beta = 110.09(4) degrees, Z = 8]. The C-B distances span the range 1.681(6)-1.743(5) Å, and B-B lengths lie between 1.756(6) and 1.795(6) Å. A similar conformation was found for the theoretical (RHF/6-31G level) structure which was fully optimized in C(1) symmetry. The r(e) distances are consistent with the dimensions derived in the experimental studies. IGLO calculations of the (11)B chemical shifts, in addition to SCF single-point energies of the GED structures, further support these observations. PMID:11666394

Brain, Paul T.; Cowie, Jill; Donohoe, David J.; Hnyk, Drahomír; Rankin, David W. H.; Reed, David; Reid, Bruce D.; Robertson, Heather E.; Welch, Alan J.; Hofmann, Matthias; Schleyer, Paul von Ragué

1996-03-13

83

12 CFR 1203.11 - Confidentiality of net worth exhibit.  

Code of Federal Regulations, 2013 CFR

12 Banks and Banking 9 2013-01-01...2013-01-01 false Confidentiality of net worth exhibit. 1203.11 Section 1203.11 Banks and Banking FEDERAL HOUSING FINANCE...1203.11 Confidentiality of net worth exhibit. Unless...

2013-01-01

84

12 CFR 1203.11 - Confidentiality of net worth exhibit.  

Code of Federal Regulations, 2012 CFR

12 Banks and Banking 9 2012-01-01...2012-01-01 false Confidentiality of net worth exhibit. 1203.11 Section 1203.11 Banks and Banking FEDERAL HOUSING FINANCE...1203.11 Confidentiality of net worth exhibit. Unless...

2012-01-01

85

46 CFR 30.10-11 - Coastwise-TB/C.  

Code of Federal Regulations, 2012 CFR

...Shipping 1 2012-10-01 2012-10-01 false Coastwise-TB/C. 30.10-11 Section 30.10-11 Shipping COAST...GENERAL PROVISIONS Definitions § 30.10-11 CoastwiseâTB/C. Under this designation shall be included all tank...

2012-10-01

86

46 CFR 188.10-11 - Chemistry laboratory.  

Code of Federal Regulations, 2011 CFR

... Shipping 7 2011-10-01 2011-10-01 false Chemistry laboratory. 188.10-11 Section 188.10-11 Shipping...Definition of Terms Used in This Subchapter § 188.10-11 Chemistry laboratory. This term includes any space in which...

2011-10-01

87

46 CFR 188.10-11 - Chemistry laboratory.  

Code of Federal Regulations, 2012 CFR

... Shipping 7 2012-10-01 2012-10-01 false Chemistry laboratory. 188.10-11 Section 188.10-11 Shipping...Definition of Terms Used in This Subchapter § 188.10-11 Chemistry laboratory. This term includes any space in which...

2012-10-01

88

19 CFR 11.12b - Labeling textile fiber products.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 2013-04-01 false Labeling textile fiber products. 11.12b Section 11.12b...STAMPING; MARKING Marking § 11.12b Labeling textile fiber products. (a) Textile fiber products imported into the United...

2013-04-01

89

10 CFR 171.11 - Exemptions.  

Code of Federal Regulations, 2013 CFR

... Section 171.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) ANNUAL FEES FOR REACTOR LICENSES AND FUEL CYCLE...exemption, the term research reactor means a nuclear reactor thatâ (i) Is licensed...

2013-01-01

90

10 CFR 436.11 - Definitions.  

Code of Federal Regulations, 2010 CFR

...Methodology and Procedures for Life Cycle Cost Analyses § 436.11 Definitions...means the fiscal year in which a life cycle cost analysis is conducted. Building...improve energy efficiency and are life cycle cost effective and that...

2009-01-01

91

10 CFR 436.11 - Definitions.  

Code of Federal Regulations, 2010 CFR

...Methodology and Procedures for Life Cycle Cost Analyses § 436.11 Definitions...means the fiscal year in which a life cycle cost analysis is conducted. Building...improve energy efficiency and are life cycle cost effective and that...

2010-01-01

92

10 CFR 61.11 - General information.  

Code of Federal Regulations, 2013 CFR

...REQUIREMENTS FOR LAND DISPOSAL OF RADIOACTIVE WASTE Licenses § 61.11 General...The types and quantities of radioactive waste to be received, possessed...purposes other than disposal of radioactive wastes; and (5) The...

2013-01-01

93

Bis[?-1-hexyl-3-(2,3,5,6,8,9,11,12-octa-hydro-1,4,7,10,13-benzopenta-oxacyclo-penta-decin-15-yl)urea]bis-(azido-sodium) chloro-form disolvate.  

PubMed

In the title compound, [Na(2)(N(3))(2)(C(21)H(34)N(2)O(6))(2)]·2CHCl(3), the sodium cation is hepta-coordinated by five O atoms of the crown ether unit of the 1-hexyl-3-(2,3,5,6,8,9,11,12-octa-hydro-1,4,7,10,13-benzopenta-oxacyclo-penta-decin-15-yl)urea (L) ligand, the O atom of the urea group of the second, symmetry-related L ligand, and one N atom of the azide anion. The experimentally determined distance 2.472?(2)?Å between the terminal azide N atom and the sodium cation is substanti-ally longer than that predicted from density functional theory (DFT) calculations (2.263?Å). The crown ethers complexing the sodium cation are related by an inversion centre and form dimers. The urea groups of the two L ligands are connected in a head-to-tail fashion by classical N-H?N hydrogen-bonding inter-actions and form a ribbon-like structure parallel to the b axis. Parallel ribbons are weakly linked through C-H?N, C-H?O and C-H?? inter-actions. PMID:22590113

Gilles, Arnaud; Barboiu, Mihail; Legrand, Yves-Marie; van Lee, Arie

2012-04-18

94

Ethyl 4-(2-eth-oxy-2-oxoeth-yl)-3-oxo-4,13-di-aza-penta-cyclo-[11.8.0.02,11.05,10.014,19]henicosa-1,5(10),6,8,11,14(19),15,17,20-nona-ene-12-carboxyl-ate  

PubMed Central

In the title compound, C26H22N2O5, the system consisting of five fused rings, being essentially planar with an r.m.s. deviation from the least-squares plane of 0.049?(3)?Å, makes a dihedral angle of 58.72?(12)° with the plane of the ethyl carboxyl­ate group immediately attached to it, and a dihedral angle of 89.48?(14)° with the plane of the ethyl carboxyl­ate group attached via the –CH2– bridge. Bond lengths indicate ?-delocalization over the whole penta­cyclic system. The mol­ecular conformation is stabilized by a weak intra­molecular C—H?O hydrogen bond. In the crystal, mol­ecules form stacks along the b-axis direction, neighboring mol­ecules within each stack being related by inversion and the shortest distance between the centroids of the pyridine rings within the stack being 3.667?(2)?Å.

Meng, Qing-Hua; Wu, Ya-Nan; Jiang, Ke; Liu, Yun

2013-01-01

95

General Business: Grades 10-12.  

ERIC Educational Resources Information Center

Thirty-five objectives and related test items assessing general business skills taught in grades 10 through 12 are included in this collection. Each objective is stated in operational terms and identified by a subject area within the hood category of general business. Objectives include the desired behavior and subject content so that students are…

Instructional Objectives Exchange, Los Angeles, CA.

96

Home Economics. Grades 10-12.  

ERIC Educational Resources Information Center

This collection contains 41 cognitive objectives and related test items for home economics, grades 10-12. It is organized into the following categories: child development (home discipline); clothing and textiles, consumer practices; design principals; health services, home management and family economics; housing; and pregnancy. Each objective is…

Instructional Objectives Exchange, Los Angeles, CA.

97

Examination of the behavior and liver and thyroid histology of juvenile rainbow trout (Oncorhynchus mykiss) exposed to high dietary concentrations of C(10)-, C(11)-, C(12)- and C(14)-polychlorinated n-alkanes.  

PubMed

Juvenile rainbow trout (Oncorhynchus mykiss) were exposed to high dietary concentrations of six polychlorinated n-alkane (PCAs) (C(10)H(15.5)C(6.5), C(10)H(15.3)Cl(6.7),C(11)H(18.4)Cl(5.6),C(12)H(19.5)Cl(6.5),C(14)H(24.9)Cl(5.1) and C(14)H(23.3)Cl(6.7)) for 21 to assess their effects on behavior and liver and thyroid histology and for 85 days to assess histology for a longer term exposure. This is the first histological work using PCAs of known carbon chain length and chlorine content and the first effort to examine the histopathology of fish exposed to PCAs. PCAs, also known as chlorinated paraffins, are complex industrial products for which there is a lack of toxicological data on individual congeners. With the exception of trout exposed to C(14)H(24.9)Cl(5.1), which had much lower exposure concentrations, many of the trout exposed to the PCAs (whole fish concentrations 0.22-5.5 microg g(-1)) showed a diminished or no startle response, loss of equilibrium, and developed a dark coloration. These responses are indicative of a narcotic toxicological mode-of-action. Histopathological lesions were observed in the livers of trout from each exposure group. However, the most severe histopathologies were observed in the livers of fish exposed to C(10)H(15.3)Cl(6.7) and C(11)H(18.4)Cl(5.6) (whole fish concentrations 0.92 and 5.5 microg g(-1), respectively), in which extensive fibrous lesions were present that were not observed in any other exposure group. Other alterations observed in all treatment groups included hepatocyte necrosis, sites of inflammation, and glycogen/lipid depletion. The relative sizes of hepatocytes of PCA exposed trout were smaller than control trout, although only a few of the observed differences were statistically significant. No lesions were present in the thyroid, although trout exposed to C(10)H(15.5)Cl(6.5) (whole fish concentration 0.84 microg g(-1)) had slightly more active thyroids, as indicated by an increased mean thyroid epithelium cell height relative to controls. It would appear that PCA toxicity is inversely related to carbon chain length, as has been observed in similar studies using mammals. The concentrations in the fish from this experiment were at levels that have been reported in invertebrates and fish from contaminated sites in the Great Lakes. However, the exposure concentrations were likely much greater in these experiments compared with the environment and require further study. PMID:11451428

Cooley, H M; Fisk, A T; Wiens, S C; Tomy, G T; Evans, R E; Muir, D C

2001-09-01

98

Design, Synthesis and Evaluation of Novel 1-(Substituted Acetyl)-4-(10-Bromo-8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine-11-Ylidene)piperidines as Antitumor Agents and Farnesyl Protein Transferase Inhibitors  

PubMed Central

Eight novel 1-(substituted acetyl)-4-(10-bromo-8-chloro-5,6-dihydro-11H-benzo[5,6] cyclohepta [1,2-b] pyridine-11-ylidene)piperidines were designed by incorporating zinc binding groups to enhance activity. The designed molecules were synthesized and were evaluated for antitumor activity in vitro in five cell lines and for farnesyl protein transferase inhibition. Test compounds (6a-h) exhibited antitumor activity in most of the cell lines but were less potent than adriamycin. Compound 6e was most active with IC50 values of <15 ?M in two cell lines tested. Test compounds also exhibited potent FPT inhibitory activity and 6c was most potent with IC50 value of <30 ?M.

Gatne, P. S.; Viswanathan, C. L.; Ambre, Premlata K.; Juvekar, Aarti

2010-01-01

99

12 CFR 327.11 - Special assessments.  

Code of Federal Regulations, 2013 CFR

...assessment period of 2009. The special assessment paid by any institution shall not exceed 10 basis points times the institution's assessment base for the second quarter 2009 risk-based assessment. (b) Special assessments after...

2013-01-01

100

12 CFR 1777.11 - Supervisory response.  

Code of Federal Regulations, 2012 CFR

...OVERSIGHT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SAFETY AND SOUNDNESS PROMPT...after OFHEO determines that a development enumerated in § 1777.10...review of a potentially adverse development. As is appropriate under...

2012-01-01

101

Milk production, milk composition, liver lipid contents and C18 fatty acid composition of milk and liver lipids in Awassi ewes fed a diet supplemented with protected cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers  

Microsoft Academic Search

The effect of a rumen protected form of a conjugated linoleic acid (pCLA) supplement containing approximately equal proportions of cis-9, trans-11 and trans-10, cis-12 isomers (11.8% and 12.1%, wt\\/wt as free fatty acid equivalents) on milk production, milk composition and liver lipid content; as well as the fatty acid profile of milk and liver in lactating sheep was studied. Fifty

F. Husvéth; E. Galamb; T. Gaál; K. Dublecz; L. Wágner; L. Pál

2010-01-01

102

High electrocatalytic activity of RRSS-[Ni{sup II}HTIM](ClO{sub 4}){sub 2} and [Ni{sup II}DMC](ClO{sub 4}){sub 2} for carbon dioxide reduction (HTIM = 2,3,9,10-tetramethyl-1,4,8,11-tetraazacyclotetradecane, DMC = C-meso-5,12-dimethyl-1,4,8,11-tetraazacyclotetradecane)  

SciTech Connect

Ni(cyclam){sup 2+} (cyclam = 1,4,8,11-tetraazacyclotetradecane) is a very effective and selective catalyst for the electrochemical reduction of CO{sub 2} to CO relative to the reduction of water to H{sub 2} in aqueous solution. However, photochemical reduction of CO{sub 2} using a photosensitizer, a sacrificial electron donor, and Ni(cyclam){sup 2+} as the catalyst has been only moderately successful. In order to understand the factors responsible for the superior electrocatalytic activity of Ni(cyclam){sup 2+} extensive studies have been carried out. While Ni(cyclam){sup +} adsorbed on the surface of a mercury electrode in an active species, other aspects of the catalytic mechanism have remained unclear. Here the authors report the catalytic activity in aqueous solution and the CO{sub 2} binding in acetonitrile of RRSS- and RSSR-NiHTIM(ClO{sub 4}){sub 2} (HTIM = 2,3,9,10-tetramethyl-1,4,8,11-tetraazacyclotetradecane) and NiDMC(ClO{sub 4}{sub 4}){sub 2} (DMC = C-meso-5,12-dimethyl-1,4,8,11-tetraazacyclotetradecane) compared to those of Ni(cyclam){sup 2+}.

Fujita, Etsuko [Brookhaven National Lab., Upton, NY (United States); Sanzenbacher, R.; Elias, H. [Technische Hochschule Darmstadt (Germany)] [and others

1994-10-12

103

Annulated bicyclo[2.2.2]octenones: 9-hydroxy-9-chloromethyl- endo -tricyclo[5.2.2.0 2,6 ]undeca-4,10-diene-3-spiro(1?-cyclopropane)-8-one and 12-hydroxy-12-chloromethyl- endo -tricyclo [8.2.2.0 2,9 ]tetradeca-13-en-11-one  

Microsoft Academic Search

A single crystal X-ray diffraction study of two annulated bicyclo[2.2.2]octenones has been carried out to establish their precise stereostructures. The compounds, with their crystal data, are:1, 9-hydroxy-9-chloromethyl-endo-tricyclo[5.2.2.02,6]undeca-4,10-diene-3-spiro(1'-cyclopropane)-8-one, C14H15O2Cl, space group P21\\/c,a=10.540(2),b=9.668(1),c=11.841(4)Å, ß=95.67(2)°,Z=4, and2, 12-hydroxy-12-chloromethyl-endo-tricyclo[8.2.2.02,9]tetradeca-13-en-11-one, C15H21O2Cl, space group C2\\/c,a=20.747(8),b=6.498(1),c=20.525(3)Å, ß=93.04(3)°,Z=8. The molecule of1 has endo stereochemistry at the ring junction and the spirocyclopropane ring is proximal to the hydroxyl group. In2,

Mino R. Caira; Ashutosh V. Bedekar; Vishwakarma Singh

1995-01-01

104

Spectroscopic studies on Co(II), Ni(II) and Cu(II) complexes with a new macrocyclic ligand: 2,9-dipropyl-3,10-dimethyl-1,4,8,11-tetraaza-5,7:12,14-dibenzocyclotetradeca-1,3,8,10-tetraene  

NASA Astrophysics Data System (ADS)

Cobalt(II), nickel(II) and copper(II) complexes containing a tetradentate macrocyclic nitrogen donor ligand i.e. 2,9-dipropyl-3,10-dimethyl-1,4,8,11-tetraaza-5,7:12,14-dibenzocyclotetradeca-1,3,8,10-tetraene have been synthesized and characterized by elemental analysis, molar conductance, magnetic moments, mass, 1H NMR, IR, electronic and EPR spectral studies. All the complexes are of high spin type and posses four-coordinated tetrahedral, five-coordinated square pyramidal and six-coordinated octahedral/tetragonal geometry. The ligand and its metal complexes were also screened against the growth of some bacteria and plant pathogenic fungi in vitro.

Chandra, Sulekh; Gupta, Lokesh Kumar

2005-04-01

105

Evidence for a type 1 diabetes susceptibility locus (IDDM10) on chromosome 10p11-q11 in a Russian population.  

PubMed

Around 20 susceptibility loci for type 1 diabetes mellitus (T1DM) have been mapped. One of these loci, IDDM10, was found on chromosome 10p11-q11. Here, we investigated whether the IDDM10 locus contributes in the susceptibility to T1DM in a Russian family dataset. One hundred and fourteen simplex Russian families, each containing two siblings (one affected with T1DM diagnosed and one nondiabetic sibling), and 97 multiplex families, containing 106 affected full sibling pairs, were studied. Genomic DNA from the venous blood of the patients was genotyped by PCR using 12 microsatellites (D10S193, D10S548, D10S565, D10S586, D10S588, D10S675, D10S1243, D10S1426, D10S1733, D10S1772, D10S1780 and D10S1783) located on chromosome 10p11-q11. Using the multipoint linkage analysis, the region of suggestive linkage, with a multipoint logarithm of odds (LOD) ratio (MLS) value of more than 2.2, was found between markers D10S1733 and D10S1780, an area of 9.0 cM on the genetic map. The maximum linkage peak (MLS = 2.85 and nonparametric logarithm = 2.68) was observed between markers D11S565 and D11S1243. Using the transmission disequilibrium test, an association of these markers, D10S565 (P overall = 0.0082) and D10S1243 (P overall = 0.017), with T1DM was shown. These results suggest the evidence for the IDDM10 susceptibility locus on chromosome 10p11-q11. PMID:15320890

Chistiakov, D A; Seryogin, Y; Savost'anov, K V; Zilberman, L I; Titovich, E V; Kuraeva, T L; Dedov, I I; Nosikov, V V

2004-09-01

106

7 CFR 12.10 - Scheme or device.  

Code of Federal Regulations, 2013 CFR

...device. 12.10 Section 12.10 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.10 Scheme or device. All or any part of the benefits listed in §...

2013-01-01

107

12 CFR 205.11 - Procedures for resolving errors.  

Code of Federal Regulations, 2013 CFR

12 Banks and Banking 2 2013-01-01...Section 205.11 Banks and Banking FEDERAL RESERVE SYSTEM...FEDERAL RESERVE SYSTEM ELECTRONIC FUND TRANSFERS (REGULATION... (i) An unauthorized electronic fund transfer;...

2013-01-01

108

12 CFR 1005.11 - Procedures for resolving errors.  

Code of Federal Regulations, 2013 CFR

12 Banks and Banking 8 2013-01-01 2013-01-01...Section 1005.11 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION ELECTRONIC FUND TRANSFERS (REGULATION... (i) An unauthorized electronic fund transfer;...

2013-01-01

109

130. FORWARD AND STARBOARD VIEW BETWEEN APOLLO 11 AND 12 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

130. FORWARD AND STARBOARD VIEW BETWEEN APOLLO 11 AND 12 RECOVERIES, SHOWING FINAL CONFIGURATION BEFORE INACTIVATION. 30 OCTOBER 1969. (NATIONAL ARCHIVES NO. 428-KN-18315) - U.S.S. HORNET, Puget Sound Naval Shipyard, Sinclair Inlet, Bremerton, Kitsap County, WA

110

45 CFR 12.11 - Special terms and conditions.  

Code of Federal Regulations, 2011 CFR

...SERVICES GENERAL ADMINISTRATION DISPOSAL AND UTILIZATION OF SURPLUS REAL PROPERTY FOR PUBLIC HEALTH PURPOSES § 12.11 Special...disposal to private nonprofit public health organizations of any surplus real property which cost the Government $1 million or...

2011-10-01

111

45 CFR 12.11 - Special terms and conditions.  

Code of Federal Regulations, 2012 CFR

...SERVICES GENERAL ADMINISTRATION DISPOSAL AND UTILIZATION OF SURPLUS REAL PROPERTY FOR PUBLIC HEALTH PURPOSES § 12.11 Special...disposal to private nonprofit public health organizations of any surplus real property which cost the Government $1 million or...

2012-10-01

112

Poly[[?2-1,4-bis-(imidazol-1-ylmethyl)-benzene](?4-3,5,9,11-tetra-oxo-4,10-diaza-tetra-cyclo-[5.5.2.02,6.08,12]tetra-dec-13-ene-4,10-diido)disilver(I)  

PubMed Central

In the title complex, [Ag2(C12H8N2O4)(C14H14N4)]n, one AgI ion, lying on a twofold rotation axis, is coordinated by two N atoms from two 3,5,9,11-tetra­oxo-4,10-diaza­tetra­cyclo­[5.5.2.02,6.08,12]tetra­dec-13-ene-4,10-diide (L) ligands in a nearly linear arrangement. The other AgI ion, lying on an inversion center, is coordinated by two O atoms from two L ligands and two N atoms from two 1,4-bis­(imidazol-1-ylmeth­yl)benzene ligands in a distorted square-planar geometry. An additional Ag?Ag [3.0119?(3)?Å] inter­action links the AgI ions into a chain along [010]. The two types of ligands have mirror symmetry and connect the AgI ions into a layer parallel to (100).

Zhang, Yongmei

2012-01-01

113

10 CFR 470.12 - Management.  

Code of Federal Regulations, 2013 CFR

...470.12 Section 470.12 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION APPROPRIATE TECHNOLOGY SMALL GRANTS...Office of the Assistant Secretary for Conservation and Solar Energy of DOE. (b) The program shall be implemented...

2013-01-01

114

10 CFR 609.12 - Project costs.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 2009-01-01 false Project costs. 609.12 Section 609.12...INNOVATIVE TECHNOLOGIES § 609.12 Project costs. (a) Before entering into...DOE shall determine the estimated Project Costs for the project that is...

2009-01-01

115

10 CFR 609.12 - Project Costs.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Project Costs. 609.12 Section 609.12...INNOVATIVE TECHNOLOGIES § 609.12 Project Costs. (a) Before entering into...DOE shall determine the estimated Project Costs for the project that is...

2010-01-01

116

12 CFR 205.10 - Preauthorized transfers.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Preauthorized transfers. 205.10 Section 205.10 Banks...FEDERAL RESERVE SYSTEM ELECTRONIC FUND TRANSFERS (REGULATION E) § 205.10 Preauthorized transfers. (a) Preauthorized transfers to...

2013-01-01

117

12 CFR 1005.10 - Preauthorized transfers.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Preauthorized transfers. 1005.10 Section 1005.10 ...FINANCIAL PROTECTION ELECTRONIC FUND TRANSFERS (REGULATION E) General § 1005.10 Preauthorized transfers. (a) Preauthorized transfers...

2013-01-01

118

12 CFR 205.10 - Preauthorized transfers.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 false Preauthorized transfers. 205.10 Section 205.10 Banks...FEDERAL RESERVE SYSTEM ELECTRONIC FUND TRANSFERS (REGULATION E) § 205.10 Preauthorized transfers. (a) Preauthorized transfers to...

2009-01-01

119

10 CFR 904.11 - Lay off of energy.  

Code of Federal Regulations, 2013 CFR

10 Energy 4 2013-01-01 2013-01-01 false Lay off of energy. 904.11 Section 904.11 Energy DEPARTMENT OF ENERGY GENERAL REGULATIONS FOR THE CHARGES FOR THE SALE OF POWER FROM THE BOULDER CANYON PROJECT Power...

2013-01-01

120

1 CFR 10.11 - Scope and sources.  

Code of Federal Regulations, 2012 CFR

...FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.11 Scope and sources. The basic text of the Public Papers consists of the documents compiled under subpart A of this part....

2012-01-01

121

10 CFR 50.12 - Specific exemptions.  

Code of Federal Regulations, 2013 CFR

... 50.12 Section 50.12 Energy NUCLEAR REGULATORY COMMISSION DOMESTIC LICENSING...Authorized by law, will not present an undue risk to the public health and safety, and...on the public interest, including the power needs to be used by the proposed...

2013-01-01

122

12 CFR 797.10 - Special review.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 false Special review. 797.10...REGULATIONS AFFECTING THE OPERATIONS OF THE NATIONAL CREDIT...Offset § 797.10 Special review. (a...any time, request a special review by the Executive Director of...

2009-01-01

123

12 CFR 797.10 - Special review.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 false Special review. 797.10...REGULATIONS AFFECTING THE OPERATIONS OF THE NATIONAL CREDIT...Offset § 797.10 Special review. (a...any time, request a special review by the Executive Director of...

2010-01-01

124

12 CFR 1750.10 - General.  

Code of Federal Regulations, 2012 CFR

...Section 1750.10 Banks and Banking OFFICE OF FEDERAL HOUSING ENTERPRISE OVERSIGHT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SAFETY AND SOUNDNESS CAPITAL Risk-Based Capital § 1750.10 General. The regulation contained in...

2012-01-01

125

10 CFR 712.12 - HRP implementation.  

Code of Federal Regulations, 2013 CFR

...Energy DEPARTMENT OF ENERGY HUMAN RELIABILITY PROGRAM Establishment of and Procedures for the Human Reliability Program Procedures § 712.12...HRP-certified individual that could indicate a reliability concern, including those...

2013-01-01

126

10 CFR 850.12 - Implementation.  

Code of Federal Regulations, 2013 CFR

...12 Energy DEPARTMENT OF ENERGY CHRONIC BERYLLIUM DISEASE PREVENTION PROGRAM Administrative...The responsible employer must manage and control beryllium exposures in all DOE beryllium activities consistent with the approved...

2013-01-01

127

5-[(E)-Benzyl-idene]-2-hy-droxy-8,9-di-phenyl-3,10-diaza-hexa-cyclo-[10.7.1.13,7.02,11.07,11.016,20]henicosa-1(19),12(20),13,15,17-pentaen-6-one  

PubMed Central

In the title compound, C38H30N2O2, the acenaphthyl­ene ring is close to being planar [maximum deviation = 0.1047?(11)?Å]. The dihedral angles between the three benzene rings and the acenaphthyl­ene system are 39.47?(3), 37.65?(3) and 44.47?(3)°. An intra­molecular O—H?N inter­action forms an S(5) hydrogen-bond ring motif. In the crystal, mol­ecules are linked into [101] chains by a set of C—H?O inter­actions.

Kumar, Raju Suresh; Osman, Hasnah; Kia, Yalda; Rosli, Mohd Mustaqim; Fun, Hoong-Kun

2011-01-01

128

12 CFR 797.10 - Special review.  

Code of Federal Regulations, 2013 CFR

...Section 797.10 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING THE OPERATIONS OF THE NATIONAL CREDIT UNION ADMINISTRATION PROCEDURES FOR DEBT COLLECTION Administrative Offset...

2013-01-01

129

Generation of 10(11) contrast 50 TW laser pulses.  

PubMed

We demonstrate what we believe to be the highest-contrast (10(11)), multiterawatt, chirped-pulse amplification (CPA) Ti:sapphire laser by applying the modified cross-polarized-wave (XPW) generation method. This method produces a contrast improvement of 3 orders of magnitude using microjoule input energy. Microjoule energy can be achieved by direct amplification without the complications of a double CPA system. The 10(11) contrast is sufficient for experiments on high-damage-threshold solid targets with focused intensities up to 10(22) W/cm(2). PMID:16642137

Chvykov, V; Rousseau, P; Reed, S; Kalinchenko, G; Yanovsky, V

2006-05-15

130

11,12,20-Trihydroxy-eicosa-8(Z)-enoic acid: a selective inhibitor of 11,12-EET-induced relaxations of bovine coronary and rat mesenteric arteries  

PubMed Central

Arachidonic acid is metabolized to four regioisomeric epoxyeicosatrienoic acids (EETs) by cytochrome P-450. 5,6-, 8,9-, 11,12-, and 14,15-EET are equipotent in relaxing bovine coronary arteries (BCAs). Vasorelaxant effects of EETs are nonselectively antagonized by 14,15-epoxyeicosa-5(Z)-enoic acid. The 11,12-EET analogs, 20-hydroxy-11,12-epoxyeicosa-8(Z)-enoic acid (20-H-11,12-EE8ZE) and 11,12,20-trihydroxyeicosa-8(Z)-enoic acid (11,12,20-THE8ZE) were synthesized and tested for antagonist activity against EET-induced relaxations in BCAs. In U-46619-preconstricted arterial rings, 5,6-, 8,9-, 11,12-, and 14,15-EET caused concentration-dependent relaxations with maximal relaxations ranging from 80 to 96%. Preincubation of arteries with 20-H-11,12-EE8ZE (10?5 M) inhibited relaxations to 14,15- and 11,12-EET, but not 5,6- and 8,9-EET; however, greatest inhibitory effect was against 11,12-EET (maximal relaxation = 80.6 ± 4.6 vs. 26.7 ± 7.4% without and with 20-H-11,12-EE8ZE, respectively). Preincubation with the soluble epoxide hydrolase inhibitor (tAUCB, 10?6 M) significantly enhanced the antagonist effect of 20-H-11,12-EE8ZE against 14,15-EET-induced relaxations (maximal relaxation = 86.6 ± 4.4 vs. 27.8 ± 3.3%, without and with 20-H-11,12-EE8ZE and tAUCB) without any change in its effect against 11,12-EET-induced relaxations. In contrast to the parent compound, the metabolite, 11,12,20-THE8ZE (10?5 M), significantly inhibited relaxations to 11,12-EET and was without effect on other EET regioisomers. Mass spectrometric analysis revealed conversion of 20-H-11,12-EE8ZE to 11,12,20-THE8ZE by incubation with BCA. The conversion was blocked by tAUCB. 14,15-Dihydroxy-eicosa-5Z-enoic acid (a 14,15-EET antagonist), but not 11,12,20-THE8ZE (an 11,12-EET antagonist), inhibited BCA relaxations to arachidonic acid and flow-induced dilation in rat mesenteric arteries. These results indicate that 11,12,20-THE8ZE is a selective antagonist of 11,12-EET relaxations and a useful pharmacological tool to elucidate the function of 11,12-EET in the cardiovascular system.

Bukhari, Ishfaq A.; Shah, Abdul Jabbar; Gauthier, Kathryn M.; Walsh, Katherine A.; Koduru, Sreenivasulu Reddy; Imig, John D.; Falck, John R.

2012-01-01

131

7 CFR 12.10 - Scheme or device.  

Code of Federal Regulations, 2012 CFR

...Scheme or device. 12.10 Section 12.10 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.10 Scheme or device. All or any part of the benefits listed in § 12.4...

2012-01-01

132

43 CFR 10.12 - Civil penalties.  

Code of Federal Regulations, 2012 CFR

...PROTECTION AND REPATRIATION REGULATIONS Human Remains, Funerary Objects, Sacred Objects...16, 1990, sells or otherwise transfers human remains, funerary objects, sacred...10(c) of this part, to repatriate human remains, funerary object, sacred...

2012-10-01

133

12 CFR 1408.10 - Review procedures.  

Code of Federal Regulations, 2012 CFR

...Section 1408.10 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION COLLECTION OF CLAIMS OWED THE UNITED STATES Administrative...or control of the Chairman of the Farm Credit System Insurance Corporation. (d) The...

2012-01-01

134

Cluster Structure of {sup 12}C and {sup 11}Be  

SciTech Connect

The structure of {sup 12}C is discussed, in particular the spectrum of states above the alpha-decay threshold. A search for the 2{sup +} excitation of the Hoyle-state is reported. The structural link between halo-like states and molecular states is explored in the case of {sup 11}Be.

Freer, M.; Haigh, P. J.; Ashwood, N. I.; Bloxham, T.; Curtis, N.; McEwan, P. [School of Physics and Astronomy, University of Birmingham, Edgbaston, Birmingham, B15 2TT (United Kingdom); Fujita, H.; Carter, J.; Usman, I. [School of Physics, University of the Witwatersrand, Johannesburg 2050 (South Africa); Buthelezi, Z.; Foertsch, S. V.; Neveling, R.; Perez, S. M.; Smit, F. D. [iThemba LABS, PO Box 722, Somerset West 7129 (South Africa); Fearick, R. W. [Physics Department, University of Cape Town, Rondebosch 7700 (South Africa); Papka, P.; Swartz, J. A. [Physics Department, University of Stellenbosch, Stellenbosch (South Africa); Bohlen, H. G.; Dorsch, T.; Kokalova, Tz. [Helmholtz-Zentrum Berlin, Glienicker Strasse 100, D-14109 Berlin (Germany)

2009-08-26

135

Sexual Coercion of Year 11-12 High School Students  

ERIC Educational Resources Information Center

|Sexual coercion in peer dating relationships was studied among 341 Year 11-12 high school students via the Adolescent Dating and Relationship Survey. Nearly 50% of females and 70% of males had relationships with similar aged partners. However, more females dated older partners and more males dated younger partners. Females also reported longer…

Dashlooty, Ashraf; Eklund, Robert C.; Randall, Nick; Heard, N. Paul; Blanksby, Brian

2008-01-01

136

Cluster Structure of 12C and 11Be  

Microsoft Academic Search

The structure of the nucleus C12 is discussed, in particular the spectrum of states above the ?-decay threshold. A search for the 2+ excitation of the Hoyle-state is reported. The structural link between halo-like states and molecular states is explored in the case of Be11.

M. Freer; H. Fujita; Z. Buthelezi; J. Carter; R. W. Fearick; S. V. Förtsch; R. Neveling; S. M. Perez; P. Papka; F. D. Smit; J. A. Swartz; I. Usman; P. J. Haigh; N. I. Ashwood; T. Bloxham; N. Curtis; P. McEwan; H. G. Bohlen; T. Dorsch; Tz. Kokalova; Ch. Schulz; C. Wheldon

2010-01-01

137

Cluster Structure of 12C and 11Be  

Microsoft Academic Search

The structure of 12C is discussed, in particular the spectrum of states above the alpha-decay threshold. A search for the 2+ excitation of the Hoyle-state is reported. The structural link between halo-like states and molecular states is explored in the case of 11Be.

M. Freer; H. Fujita; Z. Buthelezi; J. Carter; R. W. Fearick; S. V. Förtsch; R. Neveling; S. M. Perez; P. Papka; F. D. Smit; J. A. Swartz; I. Usman; P. J. Haigh; N. I. Ashwood; T. Bloxham; N. Curtis; P. McEwan; H. G. Bohlen; T. Dorsch; Tz. Kokalova; Ch. Schulz; C. Wheldon

2009-01-01

138

PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus.  

PubMed

Ras plays a pivotal role in many cellular activities, and its subcellular compartmentalization provides spatial and temporal selectivity. Here we report a mode of spatial regulation of Ras signaling in the Golgi apparatus by two highly homologous proteins PAQR10 and PAQR11 of the progestin and AdipoQ receptors family. PAQR10 and PAQR11 are exclusively localized in the Golgi apparatus. Overexpression of PAQR10/PAQR11 stimulates basal and EGF-induced ERK phosphorylation and increases the expression of ERK target genes in a dose-dependent manner. Overexpression of PAQR10/PAQR11 markedly elevates Golgi localization of HRas, NRas and KRas4A, but not KRas4B. PAQR10 and PAQR11 can also interact with HRas, NRas and KRas4A, but not KRas4B. The increased Ras protein at the Golgi apparatus by overexpression of PAQR10/PAQR11 is in an active state. Consistently, knockdown of PAQR10 and PAQR11 reduces EGF-stimulated ERK phosphorylation and Ras activation at the Golgi apparatus. Intriguingly, PAQR10 and PAQR11 are able to interact with RasGRP1, a guanine nucleotide exchange protein of Ras, and increase Golgi localization of RasGRP1. The C1 domain of RasGRP1 is both necessary and sufficient for the interaction of RasGRP1 with PAQR10/PAQR11. The simulation of ERK phosphorylation by overexpressed PAQR10/PAQR11 is abrogated by downregulation of RasGRP1. Furthermore, differentiation of PC12 cells is significantly enhanced by overexpression of PAQR10/PAQR11. Collectively, this study uncovers a new paradigm of spatial regulation of Ras signaling in the Golgi apparatus by PAQR10 and PAQR11. PMID:21968647

Jin, Ting; Ding, Qiurong; Huang, Heng; Xu, Daqian; Jiang, Yuhui; Zhou, Ben; Li, Zhenghu; Jiang, Xiaomeng; He, Jing; Liu, Weizhong; Zhang, Yixuan; Pan, Yi; Wang, Zhenzhen; Thomas, Walter G; Chen, Yan

2011-10-04

139

5-[(E)-4-Fluoro-benzyl-idene]-8-(4-fluoro-phen-yl)-2-hy-droxy-9-phenyl-3,10-diaza-hexa-cyclo-[10.7.1.13,7.02,11.07,11.016,20]henicosa-1(20),12,14,16,18-pentaen-6-one  

PubMed Central

In the title compound, C38H28F2N2O2, the piperidine ring adopts a chair conformation and the pyrrolidine ring adopts an envelope conformation with the spiro C atom as the flap atom. The naphthalene ring system makes dihedral angles of 39.89?(8), 35.33?(8) and 46.45?(8)° with the two fluoro-substituted benzene rings and the phenyl ring, respectively, while the dihedral angle between the two fluoro-substituted benzene rings is 75.21?(10)°. An intra­molecular O—H?N hydrogen bond generates an S(5) ring. In the crystal, mol­ecules are connected by C—H?O hydrogen bonds, forming supra­molecular chains propagating along the c-axis direction. Weak C—H?? inter­actions further consolidate the structure.

Kumar, Raju Suresh; Osman, Hasnah; Rahim, A. S. Abdul; Hemamalini, Madhukar; Fun, Hoong-Kun

2011-01-01

140

12 CFR 23.10 - General rule.  

Code of Federal Regulations, 2013 CFR

...does not exceed 10 percent of the bank's consolidated assets and...prescribed by this section, a national bank records the investment in a lease...into pursuant to this subpart net of any nonrecourse debt the bank has incurred to finance the...

2013-01-01

141

Formation of dimethyl tricyclo[6.2.2.01,7]dodeca-2,4,6,9, 11-pentaene-9, 10-dicarboxylates from azulenes and dimethyl acetylenedicarboxylate under high pressure and thermal rearrangement of the tricyclic compounds into heptalene-1,2-dicarboxylates  

Microsoft Academic Search

It is shown that alkylated azulenes (see 1, 12, and 13) react with dimethyl acetylenedicarboxylate (ADM) in hexane under a pressure of 6–7 kbar already at 30° to yield the corresponding dimethyl tricyclo[6.2.2.0]dodeca-2,4,6,9, 11-pentaene-9, 10-dicarboxylates (see 14, 15, and 16). These compounds decompose in apolar solvents such as decane at temperatures > 50° mainly (>95%) to the starting materials. However,

Reza Ali Fallahpour; Hans-Jürgen Hansen

1993-01-01

142

Study of the 11C(p,gamma) reaction via the indirect d(11C,12N)ntransfer reaction  

SciTech Connect

The {sup 11}C(p,{gamma}){sup 12}N reaction is expected to be an important branch point in supermassive low-metallicity stars because it could produce CNO seed nuclei before the traditional triple-alpha process turns on. In the present work, the d({sup 11}C, {sup 12}N)n transfer reaction was employed to evaluate this reaction using a radioactive ion beam of 150 MeV {sup 11}C with 6 x 10{sup 5} ions/s on target from the BEARS project at the 88-inch cyclotron at Lawrence Berkeley National Laboratory. Excellent agreement was obtained between the experimental cross sections ({theta}{sub c.m.} = 10.9{sup o} to 71.5{sup o}) and DWBA calculations. The asymptotic normalization coefficient was deduced to be (C{sub eff}{sup 12N}){sup 2} = (C{sub p1/2}{sup 12N}){sup 2} + (C{sub p3/2}{sup 12N}){sup 2} = 1.83 {+-} 0.27 fm{sup -1}.

Lee, Dongwon; Powell, James; Perajarvi, Kari; Guo, Fanqing; Moltz, Dennis; Cerny, Joseph

2008-01-07

143

Leadership Abstracts, Volume 11, Numbers 1-10, 1998.  

ERIC Educational Resources Information Center

|The abstracts in this series provide brief discussions of issues related to leadership, administration, professional development, technology, and education in community colleges. Volume 11 for 1998 contains the following 10 abstracts: (1) "What If They Learn Differently: Applying Multiple Intelligences Theory in the Community College" (Rene…

Milliron, Mark D. Ed.

1998-01-01

144

PUPILS' (AGE 10 - 11) ATTITUDES TO LOUD SOUNDS  

Microsoft Academic Search

The paper reports on an investigation into pupils' attitudes to loud sounds before and after teaching. This is part of the research project 'Design and validation of a teaching learning sequence about sound, hearing and health' for pupils aged 10 - 11 years. Pupils (41) have answered a multiple-choice questionnaire about their experiences of tinnitus, practices of headphones, attitudes to

Eva West

145

Imidazoline ring cleavage in 1,3,6,10-tetraazatetracyclo-(7. 3. 1. 0\\/sup 2,7\\/. 0\\/sup 6,13\\/)trideca-4,11-dienes, leading to the formation of diquinoxalino(1,2-. cap alpha. :2',3'-d)pyrrole derivatives  

Microsoft Academic Search

Dibenzo(d,k)-1,3,6,10-tetraazatetracyclo(7.3.1.0\\/sup 2,7\\/.0\\/sup 6,13\\/) trideca-4,11-dienes undergo addition reactions at the C\\/sub (2)\\/ carbon atom with alcohols and thiols, accompanied by cleavage of the C-N bond of the imidazoline ring, to generate diquinoxalino(1,2-..cap alpha..:2',3'-d)pyrrole derivatives. ¹H NMR spectra were recorded on Perkin-Elmer R 12B (60 MHz) and Bruker WH-90 spectrometer for CDClâ solutions at 40°C and with TMS as internal standard. ¹³C

V. N. Charushin; G. M. Petrova; G. G. Aleksandrov; L. G. Egorova; A. I. Chernishev; E. O. Sidorov; N. A. Klyuev; O. N. Chupakhin

1987-01-01

146

Growth and Land Use. (Study No. 10), Economic Implications of Land Development Alternatives. (Study No. 11), A Simulation Modeling Approach to the Study of Development Alternatives. (Study No. 12).  

National Technical Information Service (NTIS)

Study No. 10 attempts to link the population growth that poses a threat to Rookery Bay to the future economic, social and ecological stability of Collier County. A brief statistical survey was conducted; and a strategy for advocacy participation in the lo...

R. A. Lemire R. K. Davis R. M. Hirsch J. C. Zieman G. M. Hornberger

1975-01-01

147

Pharmacogenomics of the polyamine analog 3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride, CGC-11093, in the colon adenocarcinoma cell line HCT1161.  

PubMed

Polyamine analogs are known to inhibit tumorigenesis at least in part by mimicking some of the regulatory roles of natural polyamines. To begin the identification of those signaling pathways that are involved in differential cellular responses to the synthetic conformationally restricted polyamine analog CGC-11093, we conducted gene expression profiling, proteomic, and genome-wide DNA methylation and histone acetylation analyses of the HCT116 colon adenocarcinoma cell line after treatment with this analog. Gene expression analysis was performed using Affymetrix GeneChip human genome U133 Plus 2.0 arrays. Changes in protein expression were evaluated using 2D polyacrylamide gels followed by LCMS/MS. DNA methylation was measured using 6,800 element CpG island microarrays. Treatment of cells with CGC-11093 at concentrations ranging from 0.1 to 10 microM caused inhibition of cell growth and metabolic activity, but only minimally affected cell viability. Gene expression analysis showed concentration-dependent effects of CGC-11093 on the DNA/RNA binding transcription factor, cell cycle, signaling, transport, cytoskeletal/structural, and serine protease genes. Functional gene analysis revealed distinct expression patterns related to inhibition of cell cycle control, TGF beta signaling, proteasome and RNA polymerase pathways, upregulation of the aminoacyl-tRNA synthesis pathway, and perturbations in the MAPK and Wnt signaling pathways. Microarray results were validated for selected genes with real time RT PCR. Proteomics analysis showed correlative changes in the expression of proteins involved in the regulation of proteasome function (proteasome subunit Y) and tRNA synthesis. CGC-11093 treatment did not produce any detectable changes in DNA methylation or histone acetylation in cells. This study validates specific target pathways for a specific conformationally restricted polyamine analog and suggests the utility of combined gene and DNA methylation microarrays along with proteomic analyses as a useful approach to the evaluation of the mechanisms of action of anticancer drugs. PMID:17121431

Ignatenko, Natalia A; Yerushalmi, Hagit F; Watts, George S; Futscher, Bernard W; Stringer, David E; Marton, Laurence J; Gerner, Eugene W

2006-12-01

148

An investigation into understanding of geological time among 10- and 11-year-old children  

Microsoft Academic Search

This research focused on the understanding of geological time among UK children aged 10 and 11 years. The empirical study, in two stages, involved a total of 189 children in activities designed to reveal knowledge and understanding of geological time. The preliminary study with 12 children was designed to identify the most powerful and appropriate techniques to use in the

Roger Trend

1998-01-01

149

Elastic scattering and charge exchange reaction studies with (sup 6)He, (sup 10,11)Be.  

National Technical Information Service (NTIS)

The elastic scattering and charge exchange reaction of (sup 6)He, (sup 10,11)Be secondary beams on proton and (sup 12)C targets have been measured. The combined use of SISSI and SPEG allowed to obtain very good quality data in terms of energy and angular ...

P. Roussel-Chomaz M. D. Cortina-Gil W. Mittig J. M. Casandjian M. Chartier

1995-01-01

150

Combined 10pter-->p11 and 18pter-->q11 trisomy in a 7-year-old child.  

PubMed

We report a severely mentally retarded, dysmorphic girl aged 7 years with a 47,XX, +der(18), t(10;18)(p11.2;q11.2)mat. The phenotype of our patient is compared with 6 cases of trisomy 10p and 10 cases of trisomy 18q- from the literature. The short trisomic segment 10pter-10p11 appears to affect more the phenotype than the trisomic segment 18qter-q11. PMID:1388935

Lapière, J C; Verloes, A; Herens, C; Delfortrie, J; Van Maldergem, L; Gillerot, Y; Koulischer, L

1992-01-01

151

The ?12+?6-?6 and ?11-?12 bands of 12CH313CH3: A frequency analysis including data from the four lowest vibrational states  

NASA Astrophysics Data System (ADS)

High-resolution infrared spectra of the ?12+?6-?6 (around 820 cm-1) and ?11-?12 (around 370 cm-1) bands of 12CH313CH3 were measured. Frequencies from these bands together with data from the ?12 and ?5 fundamentals and the torsional bands were analyzed in a 4-state fit to determine the torsion mediated Coriolis and Fermi interactions. As compared to normal ethane this lower symmetry isotopologue shows more complicated vibrational couplings. The combined data set includes more than 6800 frequencies and was fitted to within experimental accuracy using a 78-parameter Hamiltonian. The first determination of molecular parameters for the ?11 state of 12CH313CH3 has been made and using this Hamiltonian we provide lower state energies and partition functions between 100 and 320 K in increment of 10 K for planetary data analysis.

Moazzen-Ahmadi, N.; Norooz Oliaee, J.; Horneman, V.-M.

2013-11-01

152

Designing Products. Grades 11-12. Course #8166 (Semester). Technology Education Course Guide.  

ERIC Educational Resources Information Center

|This document contains teachers' materials for a 10-module, 1-semester technology education course in product design offered in grades 11 and 12 in North Carolina. The document begins with a rationale for the development of the course; an explanation of the elements in an instructional system; a rationale for the course; a description of the…

North Carolina State Dept. of Public Instruction, Raleigh.

153

10 CFR 9.11 - Scope of subpart.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Scope of subpart. 9.11 Section 9.11 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Freedom of Information Act Regulations § 9.11 Scope of subpart. This subpart prescribes...

2010-01-01

154

10 CFR 9.11 - Scope of subpart.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Scope of subpart. 9.11 Section 9.11 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS Freedom of Information Act Regulations § 9.11 Scope of subpart. This subpart prescribes...

2013-01-01

155

Cosmic Ray Telescope Experiment (CRT), Pioneer 10/11 Program  

NASA Astrophysics Data System (ADS)

In May 1996 the electrical power on Pioneer 10 was no longer adequate to support the Cosmic Ray Telescope Experiment (CRT). In March 1997 ground based operations for the mission were terminated. The 25 years of Pioneer 10 were a remarkable voyage of discovery as it ventured into a vast new unexplored region of space. These observations by the Pioneer experiments led in the development of a new discipline of space science - heliospheric physics. For cosmic ray studies it was an incredible era, leading to the identification of new energetic particle populations and processes and initiating the study of the dynamics and large-scale structure and began the study of the dynamics and large-scale structure of the outer heliosphere. A summary of some of the principal scientific findings of the CRT experiment over this period is given in the next section. Even with the cessation of data from the Pioneer 10/11 mission there remained a great deal of scientific analysis and data archiving that required on the order of an additional three years of effort on the part of the CRT team. We have tried to select those tasks where the P10/11 CRT data have an important role to play. Special emphasis is placed on long-term synoptic studies that make use of the extended temporal and spatial coverage of the missions and the full capabilities of the CRT experiment. The major scientific objectives of this study are: (1) A phenomenological study of the modulation process in the heliosphere, thereby laying the foundation for developing a unified model of cosmic ray modulation over a complete 22 year heliomagnetic cycle; (2) These modulation studies and the temporal changes in the cosmic ray intensities also provide information on the large-scale structure and dynamics of the outer heliosphere; (3) use the galactic and anomalous cosmic ray data from Pioneer 10 to obtain a more accurate estimate of the distance to the modulation boundary and to the termination shock; (4) Use the results from (2) and from temporal variations to determine whether significant modulation occurs in the region of the heliosphere; (5)study the acceleration and transport of low energy solar interplanetary energetic particles and their relation to solar activity and interplanetary phenomena.

McDonald, Frank B.

1999-07-01

156

46 CFR 195.11-10 - Design and construction of portable vans.  

Code of Federal Regulations, 2010 CFR

...false Design and construction of portable vans. 195.11-10 Section 195.11-10...MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-10 Design and construction of portable vans. (a) The design and material...

2009-10-01

157

46 CFR 195.11-10 - Design and construction of portable vans.  

Code of Federal Regulations, 2010 CFR

...false Design and construction of portable vans. 195.11-10 Section 195.11-10...MISCELLANEOUS SYSTEMS AND EQUIPMENT Portable Vans and Tanks § 195.11-10 Design and construction of portable vans. (a) The design and material...

2010-10-01

158

12 CFR 9.11 - Investment of fiduciary funds.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Investment of fiduciary funds. 9.11 Section 9.11 Banks and Banking COMPTROLLER OF THE CURRENCY...FIDUCIARY ACTIVITIES OF NATIONAL BANKS Regulations § 9.11 Investment of fiduciary funds. A national...

2013-01-01

159

US EPA, Pesticide Product Label, , 11/12/1993  

EPA Pesticide Factsheets

... " ' .. NOV 121993 ~l!mlt!r tlll' 1:~ .. 1t·'·:11 1.1:;;.f(·IIP,di fun;r.r':,!' n!:JJ f-:."II"I.'i~ j':l" \\1.'( :\\ c .... ,tti.~1 hI" (!y.' \\~ . rlL· ~~:;11 ,;;;drr ~f'A R-.,:~ 11. ...

2011-04-19

160

1 CFR 10.12 - Format, indexes, and ancillaries.  

Code of Federal Regulations, 2012 CFR

...General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER SPECIAL EDITIONS OF THE FEDERAL REGISTER PRESIDENTIAL PAPERS Annual Publication § 10.12 Format, indexes, and ancillaries. (a) Each publication covers one...

2012-01-01

161

12. Historic American Buildings Survey Joseph Hill, Photographer July 10, ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey Joseph Hill, Photographer July 10, 1936 SOUTH ELEVATION (Copied from student's drawing, Dept. of Architecture, Armour Institute of Technology. Chicago) - Keating House, U.S. Highway 430, Fayville, Alexander County, IL

162

40 CFR 257.10-257.12 - [Reserved  

Code of Federal Regulations, 2011 CFR

...10-257.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES CRITERIA FOR CLASSIFICATION OF SOLID WASTE DISPOSAL FACILITIES AND PRACTICES Disposal Standards for the Receipt of Conditionally...

2011-07-01

163

46 CFR 12.25-10 - General requirements.  

Code of Federal Regulations, 2011 CFR

...for Ratings Other Than Able Seaman or Qualified Member of the Engine Department § 12.25-10 General requirements...endorsed as wiper may serve in any unqualified rating in the engine department. MMCs or MMDs endorsed as steward's...

2011-10-01

164

A comparison of the interaction of nitric oxide with the heteropolytungstic acids H{sub 3}PW{sub 12}O{sub 40}, H{sub 0.5}Cs{sub 2.5}PW{sub 12}O{sub 40}, HMgPW{sub 12}O{sub 40}, H{sub 8}SiW{sub 11}O{sub 38}, H{sub 4}SiW{sub 12}O{sub 40}, and H{sub 10}CoW{sub 12}O{sub 42}  

SciTech Connect

The interaction between NO and the heteropolytungstic acids (HPAs) H{sub 3}PW{sub 12}O{sub 40} (HPW), H{sub 0.5}Cs{sub 2.5}PW{sub 12}O{sub 40} (HCsPW), HMgPW{sub 12}O{sub 40} (HMgPW), H{sub 8}SiW{sub 11}O{sub 38} (HSiW{sub 11}), H{sub 4}SiW{sub 12}O{sub 40} (HSiW), and H{sub 10}CoW{sub 12}{sub 42}(HCoW) in the presence of O{sub 2}(g) was investigated. The tools employed were in situ diffuse reflectance infrared spectroscopy, X-ray powder diffraction, and solid-state {sup 1}H NMR. It was determined that protons may either be present in the HPAs secondary structure as anhydrous protons or be bound to one or two water molecules as H{sub 3}O{sup +} or H{sub 5}O{sub 2}{sup +}, respectively. A previous investigation found that HPW sorbed NO into its bulk structure as NOH{sup +}, whereas the anhydrous potassium salt of HPW exhibited weak chemisorption of NO on its surface. In the present study, it was found that NO chemisorbed weakly on the surface of the anhydrous HCsPW. For HMgPW and HSiW, IR and NMR evidence suggests that water is present as H{sub 3}O{sup +}, and the formation of surface-bound NOH{sup +} was observed. Inclusion of NO into the secondary structure as NOH{sup +} was observed for HPW, HSiW{sub 11}, and HCoW. Literature data for HPW, as well as IR and NMR results reported here, indicate that these HPAs contain water as H{sub 5}O{sub 2}{sup +}. The presence of H{sub 5}O{sub 2}{sup +} is, therefore, a prerequisite for NO incorporation as NOH{sup +} in the HPA secondary structure. These HPAs exhibited two modes of NO bonding in the secondary structure: a strongly hydrogen-bound hydrated form, NOH{sup +}{center_dot}H{sub 2}O, and a more weakly bound anhydrous form, NOH{sup +}. Evidence suggests that it is the hydrated form that decomposes, yielding N{sub 2} upon rapid heating. Both NO-containing species interact with terminal and corner-sharing oxygen atoms of the Keggin ion. Anions that are held apart by terminal oxygen-hydrogen bonds have a larger lattice parameter than those held apart by terminal oxygen-hydrogen and corner-sharing oxygen-nitrogen bonds. The lattice contraction upon NO incorporation implies activation of NO by an intimate interaction with oxygen of the Keggin anion.

Herring, A.M.; McCormick, R.L.; Boonrueng, S.R.

2000-05-18

165

Crystal engineering with heteroboranes. I. 1-Carboxy-1,2-dicarba-closo-dodecaborane(11).  

PubMed

The title compound, C(3)H(12)B(10)O(2) or 1-COOH-1,2-closo-C(2)B(10)H(11), forms centrosymmetric dimers through intermolecular hydrogen bonding between the carboxylic acid groups, resulting in the formation of an eight-membered ring [R(2)(2)(8)]. The C==O bond of the carboxylic acid group almost eclipses the unsubstituted cage C atom, with a C-C-C-O torsion angle of 2.6 (2) degrees. PMID:11706254

Welch, A J; Venkatasubramanian, U; Rosair, G M; Ellis, D; Donohoe, D J

2001-11-13

166

16 CFR Figures 11, 12 and 13 to... - Hemispherical Anvil and Curbstone Anvil  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Hemispherical Anvil and Curbstone Anvil 11, Figures 11, 12 and 13 to Part 1203 Commercial Practices CONSUMER...SAFETY STANDARD FOR BICYCLE HELMETS Pt. 1203, Figs. 11, 12, 13 Figures 11, 12 and 13 to Part...

2013-01-01

167

10 CFR 52.11 - Information collection requirements: OMB approval.  

Code of Federal Regulations, 2013 CFR

...11 Section 52.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED...CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS General Provisions § 52...requirements: OMB approval. (a) The Nuclear Regulatory...

2013-01-01

168

10 CFR 221.11 - Natural gas and ethane.  

Code of Federal Regulations, 2013 CFR

... 2013-01-01 2013-01-01 false Natural gas and ethane. 221.11 Section 221.11...PRODUCTION ACT Exclusions § 221.11 Natural gas and ethane. The supply of natural gas and ethane are excluded from this...

2013-01-01

169

12 CFR 261b.11 - Transcripts, recordings, and minutes.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Transcripts, recordings, and minutes. 261b.11 Section...MEETINGS § 261b.11 Transcripts, recordings, and minutes. (a) The agency...maintain a complete transcript or electronic recording or transcription thereof...

2013-01-01

170

(?-3,5,9,11-Tetra-oxo-4,10-diaza-tetra-cyclo-[5.5.2.02,6.08,12]tetra-dec-13-ene-4,10-diido-?2 N:N?)bis-[(2,2?-bipyridine-?2 N,N?)silver(I)] dihydrate  

PubMed Central

In the title complex, [Ag2(C12H8N2O4)(C10H8N2)2]·2H2O, the AgI ion is three-coordinated by two N atoms from a chelating 2,2?-bipyridine ligand and one N atom from an imide ligand in a Y-shaped fashion. The imide ligand and the complex lie on a twofold rotation axis. The ligand bridges two AgI ions, forming a dinuclear complex. In the crystal, O—H?O hydrogen bonds link the lattice water mol­ecules and the complex mol­ecules into a ribbon-like structure along [001]. ?–? inter­actions are observed between the pyridine rings [centroid–centroid distance = 3.8289?(14)?Å].

Zhang, Yongmei

2012-01-01

171

12 CFR 308.11 - Service of papers.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Service of papers. 308.11 Section 308.11 ...Procedure § 308.11 Service of papers. (a) By the parties. Except as otherwise provided, a party filing papers shall serve a copy upon the...

2013-01-01

172

12 CFR 19.11 - Service of papers.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Service of papers. 19.11 Section 19.11 Banks...Procedure § 19.11 Service of papers. (a) By the parties. Except as otherwise provided, a party filing papers shall serve a copy upon the...

2013-01-01

173

12 CFR 109.11 - Service of papers.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Service of papers. 109.11 Section 109.11 ...Procedure § 109.11 Service of papers. (a) By the parties. Except as otherwise provided, a party filing papers shall serve a copy upon the...

2013-01-01

174

12 CFR 263.11 - Service of papers.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Service of papers. 263.11 Section 263.11 ...Procedure § 263.11 Service of papers. (a) By the parties. Except as otherwise provided, a party filing papers shall serve a copy upon the...

2013-01-01

175

Structure studies of {sup 11}Be and {sup 12}Be: Observation of molecular rotational bands  

SciTech Connect

Excited states of {sup 11}Be have been studied with several transfer reactions. Nine states between 3.96 MeV and 25.0 MeV excitation energy show the characteristic energy dependence of a rotational band. The deduced large moment-of-inertia of this band is consistent with a two-{alpha} structure with large deformation. For {sup 12}Be four high lying states at 7.30 MeV, 10.7 MeV, 14.6 MeV and 21.7 MeV, which were observed in the {sup 9}Be({sup 15}N, {sup 12}N){sup 12}Be reaction, also form a rotational band with almost the same moment-of-inertia as for {sup 11}Be, using the tentative spin assignments of 2{sup +}-8{sup +}.

Bohlen, H. G.; Blazevic, A.; Gebauer, B.; Oertzen, W. von; Thummerer, S.; Wilpert, M. [Hahn-Meitner-Institut, Glienicker Str. 100, D-14109 Berlin (Germany); Grimes, S. M.; Massey, T. N. [Department of Physics and Astronomy, Ohio University, Athens, Ohio 45701-2979 (United States); Kalpakchieva, R. [Flerov Laboratory of Nuclear Reactions, JINR, 141980 Dubna (Russian Federation) Bulgarian Academy of Science, Sofia (Bulgaria)

1999-11-16

176

Structure Studies of {sup 11}Be and {sup 12}Be: Observation of Molecular Rotational Bands  

SciTech Connect

Excited states of {sup 11}Be have been studied with several transfer reactions. Nine states between 3.96 MeV and 25.0 MeV excitation energy show the characteristic energy dependence of a rotational band. The deduced large moment-of-inertia of this band is consistent with a two-{alpha} structure with large deformation. For {sup 12}Be four high lying states at 7.30 MeV, 10.7 MeV, 14.6 MeV and 21.7 MeV, which were observed in the {sup 9}Be({sup 15}N,{sup 12}N){sup 12}Be reaction, also form a rotational band with almost the same moment-of-inertia as for {sup 11}Be, using the tentative spin assignments of 2{sup +} - 8{sup +}.

H.G. Bohlen; A. Blazevic; B. Gebauer; S.M. Grimes; R. Kalpakchieva; T.N. Massey; W. von Oertzen; S. Thummerer; M. Wilpert

1999-12-31

177

Substorms During the August 10-11, 2000 Sawtooth Event  

NASA Astrophysics Data System (ADS)

Sawtooth events have been identified at geosynchronous orbit as large amplitude quasi-periodic (2-4 hour period) modulations of the energetic electron and ion fluxes. They are called sawtooth events because the shape of the flux versus time profiles are comprised of rapid increases followed by gradual decreases that resemble the teeth on a saw blade. Although much of the phenomenology associated with sawtooth events is substorm-like, there is still debate as to whether the individual teeth are substorms or not. Here, we examine each of the teeth associated with the August 10-11, 2000 sawtooth event in detail. We find that most of the flux enhancements were unambiguously substorms. A few were unclear or complex, and the final flux enhancement was not a substorm but a solar wind shock-associated disturbance. For the substorm events, we find that the geosynchronous particle injections were neither globally simultaneous nor globally dispersionless, but were instead consistent with a nightside source. Similarly, we show that the field dipolarizations were also not global and simultaneous. Each of the substorms was also associated with: high-latitude negative H-bays, mid and low latitude positive H-bays, a partial recovery in Sym-H, and the onset of Pi2 ULF pulsations. In addition, we show that the auroral distribution develops in a systematic way during each cycle of a sawtooth substorm event. Specifically, a localized auroral onset develops on the lower branch of a thinned double oval distribution. The location of onset is typically pre-midnight and often occurs to the west of intense omega band forms. This is followed by westward, eastward, and poleward expansion and the copious production of auroral streamers which can develop in complex patterns including a ``spoke-like'' morphology. The double oval configuration thins again during the stretching phase until the next onset occurs and the cycle repeats. A schematic representation of the auroral dynamics associated with sawtooth substorms is also presented.

Henderson, M. G.

2005-12-01

178

10 CFR 221.11 - Natural gas and ethane.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 false Natural gas and ethane. 221.11 Section 221...DEPARTMENT OF DEFENSE UNDER THE DEFENSE PRODUCTION ACT Exclusions § 221.11 Natural gas and ethane. The supply of natural gas and ethane are excluded from this...

2009-01-01

179

10 CFR 221.11 - Natural gas and ethane.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 false Natural gas and ethane. 221.11 Section 221...DEPARTMENT OF DEFENSE UNDER THE DEFENSE PRODUCTION ACT Exclusions § 221.11 Natural gas and ethane. The supply of natural gas and ethane are excluded from this...

2010-01-01

180

12 CFR 797.11 - Interest, administrative costs, and penalties.  

Code of Federal Regulations, 2013 CFR

...Section 797.11 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING THE OPERATIONS OF THE NATIONAL CREDIT UNION ADMINISTRATION PROCEDURES FOR DEBT COLLECTION Administrative Offset...

2013-01-01

181

Nqrs Data for C11H12Cl3NO4S2 (Subst. No. 1298)  

NASA Astrophysics Data System (ADS)

This document is part of Subvolume B 'Substances Containing C10H16 … Zn' of Volume 48 'Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III 'Condensed Matter'. It contains an extract of Section '3.2 Data tables' of the Chapter '3 Nuclear quadrupole resonance data' providing the NQRS data for C11H12Cl3NO4S2 (Subst. No. 1298)

Chihara, H.; Nakamura, N.

182

Venera 11 and 12 mass spectrometry of the lower Venus atmosphere  

Microsoft Academic Search

Atmospheric composition measurements were made with the Venera 11 and Venera 12 descent-probe mass spectrometers in December 1978. The Venus atmosphere contains abundant nitrogen (about 4.5% by volume). Argon isotopes (36, 38, 40 amu mass peaks), neon (20 amu), and krypton (84 amu) also occur. The argon isotopes have a total abundance of approximately 150 ppm; the Ne-20, about 10

V. G. Istomin; K. V. Grechnev; V. A. Kochnev

1979-01-01

183

Cooperation of TLR12 and TLR11 in the IRF8-Dependent IL-12 Response to Toxoplasma gondii Profilin.  

PubMed

TLRs play a central role in the innate recognition of pathogens and the activation of dendritic cells (DCs). In this study, we establish that, in addition to TLR11, TLR12 recognizes the profilin protein of the protozoan parasite Toxoplasma gondii and regulates IL-12 production by DCs in response to the parasite. Similar to TLR11, TLR12 is an endolysosomal innate immune receptor that colocalizes and interacts with UNC93B1. Biochemical experiments revealed that TLR11 and TLR12 directly bind to T. gondii profilin and are capable of forming a heterodimer complex. We also establish that the transcription factor IFN regulatory factor 8, not NF-?B, plays a central role in the regulation of the TLR11- and TLR12-dependent IL-12 response of DCs. These results suggest a central role for IFN regulatory factor 8-expressing CD8(+) DCs in governing the TLR11- and TLR12-mediated host defense against T. gondii. PMID:24078692

Raetz, Megan; Kibardin, Alexey; Sturge, Carolyn R; Pifer, Reed; Li, Haiying; Burstein, Ezra; Ozato, Keiko; Larin, Sergey; Yarovinsky, Felix

2013-09-27

184

12 CFR 552.11 - Books and records.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2012-01-01 true Books and records. 552.11 Section 552...ORGANIZATION, AND CONVERSION § 552.11 Books and records. (a) Each Federal stock association shall keep correct and complete books and records of account; shall...

2013-01-01

185

19 CFR 11.12 - Labeling of wool products to indicate fiber content.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 false Labeling of wool products to indicate fiber content. 11.12 Section 11.12 Customs Duties ...Marking § 11.12 Labeling of wool products to indicate fiber content. (a) Wool products imported into the...

2013-04-01

186

Tetra-ethyl-ammonium 12-phenyl-ethynylcarba-closo-dodeca-borate, [Et(4)N][12-PhCC-closo-CB(11)H(11)].  

PubMed

The asymmetric unit of the title compound, C(8)H(20)N(+)·C(9)H(16)B(11) (-) or [Et(4)N][12-PhCC-closo-CB(11)H(11)], consists of one cation and one anion. The [12-PhCC-closo-CB(11)H(11)](-) anion is close to possessing a non-crystallographic plane of mirror symmetry with a nearly linear B-C C-C group, with B-C C and C C-C angles of 177.15?(16) and 176.64?(17)°, respectively. PMID:21583866

Finze, Maik; Reiss, Guido J

2009-04-18

187

Tetra-ethyl-ammonium 12-phenyl-ethynylcarba-closo-dodeca-borate, [Et4N][12-PhCC-closo-CB11H11  

PubMed Central

The asymmetric unit of the title compound, C8H20N+·C9H16B11 ? or [Et4N][12-PhCC-closo-CB11H11], consists of one cation and one anion. The [12-PhCC-closo-CB11H11]? anion is close to possessing a non-crystallographic plane of mirror symmetry with a nearly linear B—C C—C group, with B—C C and C C—C angles of 177.15?(16) and 176.64?(17)°, respectively.

Finze, Maik; Reiss, Guido J.

2009-01-01

188

10 CFR 903.11 - Advance announcement of rate adjustment.  

Code of Federal Regulations, 2013 CFR

...Procedures for Public Participation...11 Advance announcement of rate adjustment...rates for a new service or revised rates for an existing service is under consideration. The announcement shall contain...customers, at public...

2013-01-01

189

10 CFR 72.11 - Completeness and accuracy of information.  

Code of Federal Regulations, 2013 CFR

...Completeness and accuracy of information. 72.11 Section 72...REQUIREMENTS FOR THE INDEPENDENT STORAGE OF SPENT NUCLEAR FUEL, HIGH-LEVEL...Completeness and accuracy of information. (a) Information provided to the...

2013-01-01

190

January 10-11, 2011: TPSAC Meeting Background Materials  

Center for Biologics Evaluation and Research (CBER)

... Summary of Briefing Package Contents: 1. UPDATED Table 1.1 - Table of Evidence for Peer-Reviewed Journals included in the FDA White Papers. ... More results from www.fda.gov/advisorycommittees/committeesmeetingmaterials/tobaccoproductsscientificadvisorycommittee

191

10 CFR 11.13 - Special requirements for transportation.  

Code of Federal Regulations, 2013 CFR

...FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...Requirements for Special Nuclear Material Access Authorization § 11.13 Special...NRC-U special nuclear material access authorization. Exceptions...

2013-01-01

192

10 CFR 11.21 - Application of the criteria.  

Code of Federal Regulations, 2013 CFR

...CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL Criteria for Determining Eligibility for Access To, Or Control Over, Special Nuclear Material § 11.21...

2013-01-01

193

Substorms during the 10-11 August 2000 sawtooth event  

NASA Astrophysics Data System (ADS)

Sawtooth events have been identified at geosynchronous orbit as large-amplitude quasiperiodic (2-4 hour period) modulations of the energetic electron and ion fluxes. They are called sawtooth events because the shape of the flux versus time profiles are composed of rapid increases followed by gradual decreases that resemble the teeth on a saw blade. Although much of the phenomenology associated with sawtooth events is substorm-like, there is still debate as to whether the individual teeth are substorms or not. Here we examine each of the teeth associated with the 10-11 August 2000 sawtooth event in detail. We find that all but one of the teeth were associated with injections at geosynchronous orbit and that most of the teeth were consistent with the hypothesis that they are predominantly caused by unusually large and longitudinally extended substorms. A few were unclear or complex, and the final flux enhancement at 1845:36 UT was not a substorm but a solar wind shock-associated disturbance. In addition, the presence of numerous dispersionless flux perturbations in the LANL SOPA data provides support for the hypothesis that solar wind pressure variations can modulate the flux profiles to some extent. For the substorm events we find that the geosynchronous particle injections were neither globally simultaneous nor globally dispersionless but were instead consistent with a nightside/duskside source in most cases. Similarly, we show that the field dipolarizations were also not global and simultaneous. Each of the substorms was also associated with high-latitude negative H bays, middle- and low-latitude positive H bays, a partial recovery in Sym-H, and the onset of Pi2 ULF pulsations. In addition, we show that the auroral distribution develops in a systematic way during each cycle of a sawtooth substorm event. Specifically, a localized auroral onset develops on the lower branch of a thinned double-oval distribution. The location of onset is typically premidnight and often occurs to the west of intense omega band forms. This is followed by westward, eastward, and poleward expansion and the copious production of auroral streamers which can develop in complex patterns including a "spoke-like" morphology. The double-oval configuration thins again during the stretching phase until the next onset occurs and the cycle repeats. A schematic representation of the auroral dynamics associated with sawtooth substorms is also presented.

Henderson, M. G.; Skoug, R.; Donovan, E.; Thomsen, M. F.; Reeves, G. D.; Denton, M. H.; Singer, H. J.; McPherron, R. L.; Mende, S. B.; Immel, T. J.; Sigwarth, J. B.; Frank, L. A.

2006-06-01

194

(11,13-Dimethyl-1,4,7,10-tetra-azacyclo-trideca-10,13-dienato)copper(II) per-chlorate  

PubMed Central

The title complex, [Cu(C11H21N4)]ClO4, comprises [CuII(L)]+ (L = 11,13-dimethyl-1,4,7,10-tetra­azacyclo­trideca-10,12-dien­ate) cations and a perchlorate anion. The Cu atom is located on a twofold crystallographic symmetry axis and is coordinated by four N atoms in a slightly distorted square-planar geometry. Inter­molecular N—H?O hydrogen bonds are present.

He, Xiao-qiang

2009-01-01

195

Newspapers and Law-Related Education. Grades 10-12.  

ERIC Educational Resources Information Center

|Designed to assist teachers of students in grades 10-12 who wish to use the newspaper as a supplemental tool in law-related education, this guide provides model lessons demonstrating ways in which the daily newspaper can enhance textbook material. Although the guide is based on ongoing law-related education programs in St. Louis Public Schools,…

Diamond, Sandra; Riekes, Linda

196

Teachers Guide to Economic Concepts: Grade 10-12.  

ERIC Educational Resources Information Center

|This grades 10-12 teachers guide is one of five resource guides developed to aid teachers in helping students in South Dakota to achieve a high degree of economic literacy. It is felt that schools must prepare students at all grade levels to develop an understanding of the economy in which they live. This guide was specifically prepared to assist…

McCabe, Milo F.

197

36 CFR 12.10 - Floral and commemorative tributes.  

Code of Federal Regulations, 2013 CFR

...CEMETERY REGULATIONS § 12.10 Floral and commemorative tributes. The placement on a grave of fresh cut or artificial flowers in or on a metal or other non-breakable rod or container designated by the superintendent is allowed at times designated by...

2013-07-01

198

Consumption of freons CFC-11 and CFC-12 by anaerobic sediments and soils  

USGS Publications Warehouse

A variety of anaerobic sediments and soils consumed CFC-11 (CFCl3) and CFC-12 (CF2Cl2). An aerobic soil did not. Active microbial metabolism was required for CFC-12 uptake in all of the sediments examined. CFC-11 uptake was faster in the presence of microbial activity, but reduced components in the sediments also resulted in nonenzymatic CFC-11 consumption in most instances. CFC-12 uptake in a culture of Clostridium pasteurianum provided a model for the sediment uptake of CFC-11 and CFC-12 that required active microbial metabolism. Consumption of CFC-11 in the presence of reduced hematin demonstrated a potential mechanism for nonenzymatic CFC-11 consumption. These findings demonstrate that CFC-11 and CFC-12 are not biochemically inert under anaerobic conditions. This suggests that anaerobic degradation of CFC-11 and CFC-12 in anaerobic landfills might prevent some disposed CFC-11 and CFC-12 from entering the atmosphere. The results also suggest that CFC-11 and CFC-12 cannot be used as stable tracers in anaerobic environments. Furthermore, although the microbial sink for atmospheric CFC-11 and CFC-12 is much less than current anthropogenic release, this sink could have a significant long-term effect on the amount of CFC-11 and CFC-12 reaching the stratosphere.

Lovley, D. R.; Woodward, J. C.

1992-01-01

199

10 CFR 712.11 - General requirements for HRP certification.  

Code of Federal Regulations, 2010 CFR

...7) A psychological evaluation consisting of a generally accepted psychological assessment (test) and a semi-structured interview; (8) An initial drug test and random drug tests for the use of illegal drugs at least once each 12 months...

2009-01-01

200

10 CFR 712.11 - General requirements for HRP certification.  

Code of Federal Regulations, 2010 CFR

...7) A psychological evaluation consisting of a generally accepted psychological assessment (test) and a semi-structured interview; (8) An initial drug test and random drug tests for the use of illegal drugs at least once each 12 months...

2010-01-01

201

Expression, purification and osteogenic bioactivity of recombinant human BMP-4, -9, -10, -11 and -14.  

PubMed

Bone morphogenetic proteins (BMPs) are cytokines from the TGF-beta superfamily, with important roles during embryonic development and in the induction of bone and cartilage tissue differentiation in the adult body. In this contribution, we report the expression of recombinant human BMP-4, BMP-9, BMP-10, BMP-11 (or growth differentiation factor-11, GDF-11) and BMP-14 (GDF-5), using Escherichia coli pET-25b vector. BMPs were overexpressed, purified by affinity his-tag chromatography and shown to induce the expression of early markers of bone differentiation (e.g. smad-1, smad-5, runx2/cbfa1, dlx5, osterix, osteopontin, bone sialoprotein and alkaline phosphatase) in C2C12 cells and in human adipose stem cells. The described approach is a promising method for producing large amounts of different recombinant BMPs that show potential for novel biomedical applications. PMID:18950713

Bessa, P C; Cerqueira, M T; Rada, T; Gomes, M E; Neves, N M; Nobre, A; Reis, R L; Casal, M

2008-10-04

202

US EPA, Pesticide Product Label, 10% SABADILLA DUST, 11 ...  

EPA Pesticide Factsheets

... ( '" I ( It)\\ , .. i , , I \\1 1 1(1 \\ , , ,. CAU TI 0 N: Keep Out Of Reaf,h Oi Chddren (,I il!)'\\, il .. . , ; 1 i , , , ' I \\ " I i' I ..? 1 \\! ,! : I ,I ! ~,f It,.... I ..., . J I /~II/ i I I ...

2011-04-21

203

Trisomy 18q: 46,XX,-10,+der(10) t(10;18) (p15;q12) pat: a case report.  

PubMed

A 2-month-old female with intrauterine and postnatal growth retardation, multiple congenital anomalies, absent right kidney, congenital heart disease was investigated. Her karyotype revealed, 46,XX,-10,+der(10), t(10;18) (p15;q12) pat. The child died at 2 months 2 weeks. This is the third case of trisomy 18q resulting from translocation of chromosome 10 and 18. PMID:1466569

Murthy, S K; Kar, B; Prabhakara, K; Krishnamurthy, D S

1992-01-01

204

Cosmic Ray Telescope Experiment (CRT), Pioneer 10/11 Program.  

National Technical Information Service (NTIS)

In May 1996 the electrical power on Pioneer 10 was no longer adequate to support the Cosmic Ray Telescope Experiment (CRT). In March 1997 ground based operations for the mission were terminated. The 25 years of Pioneer 10 were a remarkable voyage of disco...

F. B. McDonald

1999-01-01

205

Neutron knockout of {sup 12}Be populating neutron-unbound states in {sup 11}Be  

SciTech Connect

Neutron-unbound resonant states of {sup 11}Be were populated in neutron knockout reactions from {sup 12}Be and identified by {sup 10}Be-n coincidence measurements. A resonance in the decay-energy spectrum at 80(2) keV was attributed to a highly excited unbound state in {sup 11}Be at 3.949(2) MeV decaying to the 2{sup +} excited state in {sup 10}Be. A knockout cross section of 15(3) mb was inferred for this 3.949(2) MeV state, suggesting a spectroscopic factor near unity for this 0p3/2{sup -} level, consistent with the detailed shell model calculations.

Peters, W. A. [Department of Physics and Astronomy, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854 (United States); Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48824 (United States); National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824 (United States); Baumann, T.; Lecouey, J.-L.; Schiller, A.; Yoneda, K. [National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824 (United States); Brown, B. A.; Frank, N.; Thoennessen, M. [Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48824 (United States); National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, Michigan 48824 (United States); Brown, J. [Department of Physics, Wabash College, Crawfordsville, Indiana 47933 (United States); DeYoung, P. A.; Peaslee, G. F. [Department of Physics, Hope College, Holland, Michigan 49423 (United States); Finck, J. E. [Department of Physics, Central Michigan University, Mt. Pleasant, Michigan 48859 (United States); Jones, K. L. [Department of Physics and Astronomy, Rutgers, State University of New Jersey, Piscataway, New Jersey 08854 (United States); Luther, B. [Department of Physics, Concordia College, Moorhead, Minnesota 56562 (United States); Rogers, W. F. [Department of Physics, Westmont College, Santa Barbara, California 93108 (United States); Tostevin, J. A. [Department of Physics, Faculty of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey GU27XH (United Kingdom)

2011-05-15

206

20,23,26,29,32,35,38,41-Octa-oxa-5,9,13-triaza-penta-cyclo-[15.14.10.13,30.17,11.115,19]tetra-tetra-conta-1,3(42),7,9,11(44),15(43),16,18,30-nona-ene-6,12-dione acetone mono-solvate  

PubMed Central

In the crystal structure of the title compound, C33H39N3O10·C3H6O, the acetone mol­ecule is encapsulated into the cavity of the cryptand and fixed by two N—H?O and one C—H?O hydrogen bond. C—H?O and C—H?N inter­actions link neighbouring cryptands. The dihedral angles between the pyridine ring and the benzene rings are 86.47?(17) and 85.53?(13)°.

Pan, Shaowu; Yang, Dengke; Yang, Yu; Jiang, Lasheng

2012-01-01

207

Recoil-corrected continuum shell model calculations for 11B(p,n)11C, 11B(p,p')11B*, 12C(e,e'x)  

NASA Astrophysics Data System (ADS)

Background: The recoil-corrected continuum shell model provides coupled-channels solutions for bound and unbound wave functions from realistic effective interactions. The wave functions are antisymmetric and contain no spurious components because the calculations are performed in the center-of-mass system.Purpose: This model has now been extended to include 1?? excitations in the structure of p-shell target (residual) nuclei, hence allowing 0s-shell knockout processes. Several reactions involving the 12C compound system are investigated to demonstrate the utility of the model.Methods: The states of 11B and 11C are constructed in the nonspurious 0?? plus 1?? model space. An interaction, fitted to Cohen and Kurath (8-16) plus Reid soft core g-matrix elements, is employed. One nucleon is coupled to these states to create a basis for the bound and scattering states for 12C.Results: Calculated elastic and inelastic cross sections agree well with available data. The calculated transverse response at high momentum transfer is lower than that extracted from data. Although significant, meson exchange currents are not sufficient to give agreement with data. Likewise inclusion of 0s-shell knockout is not sufficient to provide agreement. The high-energy octupole resonance appears at low momentum transfer and an energy of 106/A1/3.Conclusions: The model should provide meaningful predictions for states near the proton drip line via the (p,n) reaction. Coupled-channels solutions are necessary for describing 12C(e,e'x) at low momentum transfer. Lack of strength at low energy and momentum transfer in optical model calculations of 12C(e,e'x) is at least partly attributable to the omission of giant resonances. Data for (?+,?+'p)/(??,??'p) could verify this conclusion. Lack of strength in the transverse response may be attributable to recoil terms which are omitted in most calculations.

Halderson, Dean

2013-07-01

208

Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation.  

PubMed

Epoxyeicosatrienoic acids (EETs) are considered to be endothelium-derived hyperpolarizing factors, and are potent activators of the large-conductance, Ca(2+)-activated K(+) (BK(Ca)) channel in vascular smooth muscle. Here, we investigate the signal transduction pathway involved in the activation of BK(Ca) channels by 11,12-EET and 11,12-EET stable analogs in rat mesenteric vascular smooth muscle cells. 11,12-EET and the 11,12-EET analogs, 11-nonyloxy-undec-8(Z)-enoic acid (11,12-ether-EET-8-ZE), 11-(9-hydroxy-nonyloxy)-undec-8(Z)-enoic acid (11,12-ether-EET-8-ZE-OH) and 11,12-trans-oxidoeicosa-8(Z)-enoic acid (11,12-tetra-EET-8-ZE), caused vasorelaxation of mesenteric resistance arteries. Mesenteric myocyte whole-cell (perforated-patch) currents were substantially (approximately 150%) increased by 11,12-EET and 11,12-EET analogs. Single-channel recordings were conducted to identify the target for 11,12-EET. 11,12-EET and 11,12-EET analogs also increased mesenteric myocyte BK(Ca) channel activity in cell-attached patches. Similar results were obtained in cell-free patches. Baseline mesenteric myocyte BK(Ca) channel activity (NPo) in cell-free patches averaged less than 0.001 at +50 mV and 11,12-EET (1 micromol/L) increased NPo to 0.03+/-0.02 and 11,12-EET analogs (1 micromol/L) increased NPo to 0.09+/-0.006. Inhibition of protein phosphatase 2A (PP2A) activity with okadaic acid (10 nmol/L) completely reversed 11,12-EET stimulated BK(Ca) channel activity and greatly attenuated 11,12-ether-EET-8-ZE mesenteric resistance artery vasorelaxation. 11,12-EET and 11,12-EET analogs increased mesenteric myocyte PP2A activity by 3.5-fold. Okadaic acid and the EET inhibitor, 14,15-epoxyeicosa-5(Z)-enoic acid (14,15-EEZE) inhibited the 11,12-EET mediated increase in PP2A activity. These findings provide initial evidence that PP2A activity contributes to 11,12-EET and 11,12-EET analog activation of mesenteric resistant artery BK(Ca) channels and vasorelaxation. PMID:17259072

Dimitropoulou, Christiana; West, Lashondra; Field, Mary B; White, Richard E; Reddy, L Manmohan; Falck, John R; Imig, John D

2006-11-07

209

Solid State Extrusion of Nylons 11 and 12; Processing, Morphology and Properties.  

National Technical Information Service (NTIS)

Monofilaments of poly(11-amino-undecanoic acid) (nylon 11) and poly-(laurylactam) (nylon 12) have been produced via solid state extrusion in an Instron capillary rheometer. The resulting morphology plus physical and mechanical properties were investigated...

W. G. Perkins R. S. Porter

1979-01-01

210

12 CFR 1310.11 - Considerations in making proposed and final determinations.  

Code of Federal Regulations, 2013 CFR

12 Banks and Banking 9 2013-01-01 2013-01-01...11 Section 1310.11 Banks and Banking FINANCIAL STABILITY OVERSIGHT COUNCIL AUTHORITY...SUPERVISION AND REGULATION OF CERTAIN NONBANK FINANCIAL COMPANIES Determinations §...

2013-01-01

211

Evidence that the trans -10, cis -12 isomer of conjugated linoleic acid induces body composition changes in mice  

Microsoft Academic Search

We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9,trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body\\u000a protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced

Jayne M. Storkson; Karen J. Albright; Wei Liu; Michael W. Pariza

1999-01-01

212

11,12-Dichloro-dibenzo[a,c]phenazine  

PubMed Central

The title compound, C20H10Cl2N2, has crystallographic twofold rotational symmetry [maximum deviation from the least-squares plane = 0.038?(1)?Å]. In the crystal, weak ?–? ring stacking inter­actions occur down the a-axis direction [minimum centroid–centroid separation = 3.7163?(8)?Å].

Imeri, Arta; Glagovich, Neil M.; Crundwell, Guy

2013-01-01

213

46 CFR 12.40-11 - Citizenship and identity.  

Code of Federal Regulations, 2010 CFR

(a) In lieu of the requirements of § 10.221 of this subchapter, a non-resident alien may apply for a Coast Guard-issued merchant mariner credential, endorsed and valid only for service in the steward's department of a...

2009-10-01

214

Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives  

Microsoft Academic Search

Conjugated linoleic acid (CLA) has been reported to decrease stearoyl-CoA desaturase (SCD) activity by decreasing mRNA expression. This investigation was designed to determine whether structurally related compounds of CLA have a direct inhibitory effect on SCD activity. Trans-10,cis-12 CLA had strong inhibitory activity on SCD while cis-9,trans-11, and trans-9,trans-11 isomers had no effect. Trans-10 octadecenoate was not inhibitory, whereas cis-12

Jayne M. Storkson; James M. Ntambi; Mark E. Cook; Charles J. Sih; Michael W. Pariza

2000-01-01

215

46 CFR 12.05-11 - General provisions respecting merchant mariner's document endorsed for service as able seamen.  

Code of Federal Regulations, 2011 CFR

...mariner's document endorsed for service as able seamen. 12.05-11 Section 12.05-11 Shipping COAST GUARD, DEPARTMENT OF HOMELAND...REQUIREMENTS FOR RATING ENDORSEMENTS Able Seamen § 12.05-11 General provisions respecting...

2011-10-01

216

Software Implementation of a High Speed Interface Between a Pdp-10 and Several Pdp-11S.  

National Technical Information Service (NTIS)

The DMA10 is a high speed link between a PDP-10 and up to eight PDP-11s; specifically, the PDP-10 shares sections of its memory with the PDP-11s. The two segment concept on the PDP-10 of shared/reentrant code and non-shared code is implemented. The inclus...

N. P. I . De Mesa

1975-01-01

217

Toll-Like Receptor 11 (PAT-APPL-10-511 795).  

National Technical Information Service (NTIS)

The invention describes isolated Toll-like receptor 11 ('TLR11') and Toll-like receptor 12 ('TLR12') polypeptides as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and hos...

R. M. Medzhitov

2003-01-01

218

10 CFR 100.11 - Determination of exclusion area, low population zone, and population center distance.  

Code of Federal Regulations, 2013 CFR

...Section 100.11 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) REACTOR SITE CRITERIA Evaluation Factors for Stationary Power Reactor Site Applications Before January 10, 1997 and for Testing Reactors § 100.11...

2013-01-01

219

10 CFR 950.11 - Terms and conditions of the Conditional Agreement.  

Code of Federal Regulations, 2013 CFR

10 Energy 4 2013-01-01 2013-01-01...950.11 Section 950.11 Energy DEPARTMENT OF ENERGY STANDBY SUPPORT FOR CERTAIN NUCLEAR PLANT DELAYS Standby Support...cover principal or interest costs and to cover incremental...

2013-01-01

220

10 CFR 1044.11 - How do you protect the information that you want to disclose?  

Code of Federal Regulations, 2013 CFR

10 Energy 4 2013-01-01 ...11 Section 1044.11 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS...unclassified controlled nuclear information you plan to...Special Access Program, and Weapon Data information;...

2013-01-01

221

Early Life Determinants of Physical Activity in 11 to 12 Year Olds: Cohort Study  

Microsoft Academic Search

Objective: To examine factors in early life (up to age 5 years) that are associated with objectively measured physical activity in 11-12 year olds. Design: Prospective cohort study. Setting: Avon longitudinal study of parents and children, United Kingdom. Participants: Children aged 11-12 years from the Avon longitudinal study of parents and children. Main outcome measure: Physical activity levels in counts

Calum Mattocks; Kevin Deere; Sam Leary; Andy Ness; Kate Tilling; Steven N. Blair; Chris Riddoch

2008-01-01

222

Experiences of learning French: a snapshot at Years 11, 12 and 13  

Microsoft Academic Search

This paper considers the attitudes of students in Years 11, 12 and 13 towards French and, in particular, how they view the reasons behind their level of achievement. It reports findings from a small-scale pilot study, conducted in four schools and colleges, involving 83 students in Year 11, 26 in Year 12 and 14 in Year 13. The findings indicate

Suzanne Graham

2002-01-01

223

7 CFR 12.11 - Action based upon advice or action of USDA.  

Code of Federal Regulations, 2012 CFR

... Action based upon advice or action of USDA. 12.11 Section 12.11 Agriculture... Action based upon advice or action of USDA. The provisions of part 718 of...if it is determined by the appropriate USDA agency that the action of a person...

2012-01-01

224

7 CFR 12.11 - Action based upon advice or action of USDA.  

Code of Federal Regulations, 2013 CFR

... Action based upon advice or action of USDA. 12.11 Section 12.11 Agriculture... Action based upon advice or action of USDA. The provisions of part 718 of...if it is determined by the appropriate USDA agency that the action of a person...

2013-01-01

225

A quest for porphyrins in lunar soil: Samples from Apollo 11, 12 and 14  

Microsoft Academic Search

Pigments exhibiting porphyrin-like behavior were detected in samples from Apollo 11 and 12. Those from Apollo 11 appeared to be directly related to the rocket exhaust of the descent engine; those from Apollo 12 from indigenous lunar material. Porphyrin-like pigments were not detected in a sample from Apollo 14.

G. W. Hodgson; K. Kvenvolden; Etta Peterson; C. Ponnamperuma

1972-01-01

226

16p11.2-p12.2 duplication syndrome; a genomic condition differentiated from euchromatic variation of 16p11.2.  

PubMed

Chromosome 16 contains multiple copy number variations (CNVs) that predispose to genomic disorders. Here, we differentiate pathogenic duplications of 16p11.2-p12.2 from microscopically similar euchromatic variants of 16p11.2. Patient 1 was a girl of 18 with autism, moderate intellectual disability, behavioural difficulties, dysmorphic features and a 7.71-Mb (megabase pair) duplication (16:21?521?005-29?233?146). Patient 2 had a 7.81-Mb duplication (16:21?382?561-29?191?527), speech delay and obsessional behaviour as a boy and, as an adult, short stature, macrocephaly and mild dysmorphism. The duplications contain 65 coding genes of which Polo-like kinase 1 (PLK1) has the highest likelihood of being haploinsufficient and, by implication, a triplosensitive gene. An additional 1.11-Mb CNV of 10q11.21 in Patient 1 was a possible modifier containing the G-protein-regulated inducer of neurite growth 2 (GPRIN2) gene. In contrast, the euchromatic variants in Patients 3 and 4 were amplifications from a 945-kb region containing non-functional immunoglobulin heavy chain (IGHV), hect domain pseudogene (HERC2P4) and TP53-inducible target gene 3 (TP53TG3) loci in proximal 16p11.2 (16:31?953?353-32?898?635). Paralogous pyrosequencing gave a total copy number of 3-8 in controls and 8 to >10 in Patients 3 and 4. The 16p11.2-p12.2 duplication syndrome is a recurrent genomic disorder with a variable phenotype including developmental delay, dysmorphic features, mild to severe intellectual disability, autism, obsessive or stereotyped behaviour, short stature and anomalies of the hands and fingers. It is important to differentiate pathogenic 16p11.2-p12.2 duplications from harmless, microscopically similar euchromatic variants of proximal 16p11.2, especially at prenatal diagnosis. PMID:22828807

Barber, John C K; Hall, Victoria; Maloney, Viv K; Huang, Shuwen; Roberts, Angharad M; Brady, Angela F; Foulds, Nicki; Bewes, Beverley; Volleth, Marianne; Liehr, Thomas; Mehnert, Karl; Bateman, Mark; White, Helen

2012-07-25

227

10 CFR 1016.12 - Termination of security facility approval.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Termination of security facility approval. 1016.12 Section 1016.12 Energy DEPARTMENT OF ENERGY (GENERAL...SAFEGUARDING OF RESTRICTED DATA Physical Security § 1016.12 Termination of...

2013-01-01

228

11C level structure via the 10B(p, ?) reaction  

NASA Astrophysics Data System (ADS)

The reaction 10B(p, ?)11C has been investigated in the energy range Ep=0.07-2.20 MeV. The broad resonant structure previously observed in the ground state transition near Ep=1.2 MeV has been seen also in ?-ray transitions to excited states. The observed excitation functions as well as the ?-ray angular distributions can be explained by assuming several broad overlapping resonances. The low-energy data (Ep<0.6 MeV) reveal the existence of two s-wave resonances at Ep=0.010 and 0.56 MeV. Spectroscopic factors for several final states have been obtained from observation of direct capture processes to them; they are in fair agreement with results from stripping reaction studies. The present data also provide information on partial and total widths of the states at Ex=8-9 MeV. The energy range investigated corresponds to the temperature range of T=(0.01-5)×109 K. The thermonuclear reaction rates deduced from the present results are compared with previously reported values. NUCLEAR REACTIONS 10B(p, ?), Ep=0.07-2.20 MeV; measured ? yield for 11C states up to Ex=10.7 MeV. Deduced resonance parameters, branching ratios, and direct capture contributions for proton-unbound states; deduced spectroscopic factors, ???tot, and ?tot for several ?-unbound states. Calculated thermonuclear reaction rate for T=(0.01-5)×109 K.

Wiescher, M.; Boyd, R. N.; Blatt, S. L.; Rybarcyk, L. J.; Spizuoco, J. A.; Azuma, R. E.; Clifford, E. T. H.; King, J. D.; Görres, J.; Rolfs, C.; Vlieks, A.

1983-10-01

229

Epoxy derivatives of aromatic polycyclic hydrocarbons. The synthesis of dibenz[a,c]anthracene 10,11-oxide and its metabolism by rat liver preparations  

PubMed Central

The synthesis of dibenz[a,c]anthracene 10,11-oxide is described. The oxide was unstable and was rapidly decomposed with cold mineral acid into a mixture of 10- and 11- hydroxydibenz[a,c]anthracene. The oxide was converted by rat liver microsomal preparations and homogenates into a product that is probably 10,11-dihydro-10,11-dihydroxydibenz[a,c]anthracene and which was identical with the metabolite formed when dibenz[a,c]anthracene was metabolized by rat liver homogenates. The oxide did not react either chemically or enzymically with GSH. 10,11-Dihydrodibenz[a,c]anthracene and 10,11-dihydrodibenz[a,c]anthracene 12,13-oxide were both metabolized by rat liver preparations into trans-10,11,12,13-tetrahydro-10,11-dihydroxydibenz[a,c] anthracene and the oxide was converted chemically into this dihydroxy compound, and it reacted chemically but not enzymically with GSH. In the alkylation of 4-(p-nitrobenzyl)pyridine, the `K-region' epoxide, dibenz[a,h]anthracene 5,6-oxide, was more active than either dibenz[a,c]anthracene 10,11-oxide or 10,11-dihydrobenz[a,c]anthracene 12,13-oxide.

Sims, P.

1972-01-01

230

Microdeletion syndrome 16p11.2-p12.2: clinical and molecular characterization.  

PubMed

The pericentromeric region on 16p appears to be susceptible to chromosomal rearrangements and several patients with rearrangements in this region have been described. We report on a further patient with a microdeletion 16p11.2-p12.2 in the context of described patients with a deletion in the pericentromeric region of 16p. Minor facial anomalies, feeding difficulties, significant delay in speech development, and recurrent ear infections are common symptoms of the microdeletion syndrome 16p11.2-p12.2. All reported patients so far share a common distal breakpoint at 16p12.2 but vary in the proximal breakpoint at 16p11.2. The microdeletion 16p11.2-p12.2 should be distinguished from the approximately 500 kb microdeletion in 16p11.2 which seems to be associated with autism but not with facial manifestations, feeding difficulties, or developmental delay. PMID:19676056

Hempel, Maja; Rivera Brugués, Nuria; Wagenstaller, Janine; Lederer, Gaby; Weitensteiner, Andrea; Seidel, Heide; Meitinger, Thomas; Strom, Tim M

2009-10-01

231

Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries.  

PubMed

Measles, caused by measles virus (MeV), is a common infection in children. MeV is a member of the genus Morbillivirus and is most closely related to rinderpest virus (RPV), which is a pathogen of cattle. MeV is thought to have evolved in an environment where cattle and humans lived in close proximity. Understanding the evolutionary history of MeV could answer questions related to divergence times of MeV and RPV. We investigated divergence times using relaxed clock Bayesian phylogenetics. Our estimates reveal that MeV had an evolutionary rate of 6.0-6.5 x 10(-4) substitutions/site/year. It was concluded that the divergence time of the most recent common ancestor of current MeV was the early 20th century. And, divergence between MeV and RPV occurred around the 11th to 12th centuries. The result was unexpected because emergence of MeV was previously considered to have occurred in the prehistoric age. MeV may have originated from virus of non-human species and caused emerging infectious diseases around the 11th to 12th centuries. In such cases, investigating measles would give important information about the course of emerging infectious diseases. PMID:20202190

Furuse, Yuki; Suzuki, Akira; Oshitani, Hitoshi

2010-03-04

232

High potassium intake enhances the inhibitory effect of 11,12-EET on ENaC.  

PubMed

High dietary potassium stimulates the renal expression of cytochrome P450 (CYP) epoxygenase 2C23, which metabolizes arachidonic acid (AA). Because the AA metabolite 11,12-epoxyeicosatrienoic acid (11,12-EET) can inhibit the epithelial sodium channel (ENaC) in the cortical collecting duct, we tested whether dietary potassium modulates ENaC function. High dietary potassium increased 11,12-EET in the isolated cortical collecting duct, an effect mimicked by inhibiting the angiotensin II type I receptor with valsartan. In patch-clamp experiments, a high potassium intake or treatment with valsartan enhanced AA-induced inhibition of ENaC, an effect mediated by a CYP-epoxygenase-dependent pathway. Moreover, high dietary potassium and valsartan each augmented the inhibitory effect of 11,12-EET on ENaC. Liquid chromatography/mass spectrometry showed that the rate of EET conversion to dihydroxyeicosatrienoic acids (DHET) was lower in renal tissue obtained from rats on a high-potassium diet than from those on a control diet, but this was not a result of altered expression of soluble epoxide hydrolase (sEH). Instead, suppression of sEH activity seemed to be responsible for the 11,12-EET-mediated enhanced inhibition of ENaC in animals on a high-potassium diet. Patch-clamp experiments demonstrated that 11,12-DHET was a weak inhibitor of ENaC compared with 11,12-EET, whereas 8,9- and 14,15-DHET were not. Furthermore, inhibition of sEH enhanced the 11,12-EET-induced inhibition of ENaC similar to high dietary potassium. In conclusion, high dietary potassium enhances the inhibitory effect of AA and 11,12-EET on ENaC by increasing CYP epoxygenase activity and decreasing sEH activity, respectively. PMID:20595684

Sun, Peng; Lin, Dao-Hong; Yue, Peng; Jiang, Houli; Gotlinger, Katherine H; Schwartzman, Michal L; Falck, John R; Goli, Mohan; Wang, Wen-Hui

2010-07-01

233

10 CFR 436.12 - Life cycle cost methodology.  

Code of Federal Regulations, 2010 CFR

... 2009-01-01 2009-01-01 false Life cycle cost methodology. 436.12 Section 436...PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.12 Life cycle cost methodology. The life cycle cost...

2009-01-01

234

10 CFR 436.12 - Life cycle cost methodology.  

Code of Federal Regulations, 2010 CFR

... 2010-01-01 2010-01-01 false Life cycle cost methodology. 436.12 Section 436...PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.12 Life cycle cost methodology. The life cycle cost...

2010-01-01

235

10 CFR 52.12 - Scope of subpart.  

Code of Federal Regulations, 2013 CFR

...12 Section 52.12 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED...CERTIFICATIONS, AND APPROVALS FOR NUCLEAR POWER PLANTS Early Site Permits ...approval of a site for one or more nuclear power facilities separate from the...

2013-01-01

236

10 CFR 436.12 - Life cycle cost methodology.  

Code of Federal Regulations, 2013 CFR

... 2013-01-01 2013-01-01 false Life cycle cost methodology. 436.12 Section 436...PLANNING PROGRAMS Methodology and Procedures for Life Cycle Cost Analyses § 436.12 Life cycle cost methodology. The life cycle cost...

2013-01-01

237

12 CFR 1320.10 - Factors for consideration in designations.  

Code of Federal Regulations, 2012 CFR

...consideration in designations. 1320.10 Section 1320.10 Banks and Banking FINANCIAL...Determinations and Hearings § 1320.10 Factors for consideration in designations...under this part, the Council shall take into consideration: (a)...

2012-01-01

238

Mutations in C10orf11, a Melanocyte-Differentiation Gene, Cause Autosomal-Recessive Albinism  

PubMed Central

Autosomal-recessive albinism is a hypopigmentation disorder with a broad phenotypic range. A substantial fraction of individuals with albinism remain genetically unresolved, and it has been hypothesized that more genes are to be identified. By using homozygosity mapping of an inbred Faroese family, we identified a 3.5 Mb homozygous region (10q22.2–q22.3) on chromosome 10. The region contains five protein-coding genes, and sequencing of one of these, C10orf11, revealed a nonsense mutation that segregated with the disease and showed a recessive inheritance pattern. Investigation of additional albinism-affected individuals from the Faroe Islands revealed that five out of eight unrelated affected persons had the nonsense mutation in C10orf11. Screening of a cohort of autosomal-recessive-albinism-affected individuals residing in Denmark showed a homozygous 1 bp duplication in C10orf11 in an individual originating from Lithuania. Immunohistochemistry showed localization of C10orf11 in melanoblasts and melanocytes in human fetal tissue, but no localization was seen in retinal pigment epithelial cells. Knockdown of the zebrafish (Danio rerio) homolog with the use of morpholinos resulted in substantially decreased pigmentation and a reduction of the apparent number of pigmented melanocytes. The morphant phenotype was rescued by wild-type C10orf11, but not by mutant C10orf11. In conclusion, we have identified a melanocyte-differentiation gene, C10orf11, which when mutated causes autosomal-recessive albinism in humans.

Gr?nskov, Karen; Dooley, Christopher M.; ?stergaard, Elsebet; Kelsh, Robert N.; Hansen, Lars; Levesque, Mitchell P.; Vilhelmsen, Kaj; M?llgard, Kjeld; Stemple, Derek L.; Rosenberg, Thomas

2013-01-01

239

Comets C/2003 X5-X11 and Y2-Y10 (SOHO)  

NASA Astrophysics Data System (ADS)

Further to IAUC 8356, K. Battams reports measurements for additional Kreutz sungrazing comets found on SOHO website C2 images by M. Boschat (C/2003 X5, X7, Y5, Y8), X.-m. Zhou (C/2003 X6, X9, X11), T. Hoffman (C/2003 X8), X. Leprette (C/2003 X10, Y2), R. Matson (2003 Y3, Y9, Y10), R. Kracht (C/2003 Y4, Y7), and J. Sachs (C/2003 Y6). C/2003 Y6 and Y7 were also visible on C3 images. The reductions by B. G. Marsden (and by R. Kisala for C/2003 Y8, Y9, Y10) and orbital elements by Marsden appear on the MPECs cited below. Comet 2003 UT R.A. (2000) Decl. MPEC C/2003 X5 Dec. 4.896 16 46.9 -24 12 2004-L24 C/2003 X6 6.396 16 52.2 -24 20 2004-L24 C/2003 X7 7.829 16 58.6 -24 27 2004-L24 C/2003 X8 8.246 17 00.9 -24 31 2004-L24 C/2003 X9 8.621 17 02.2 -24 34 2004-L24 C/2003 X10 11.188 17 14.5 -24 41 2004-L25 C/2003 X11 13.588 17 25.7 -24 57 2004-L25 C/2003 Y2 19.621 17 53.6 -25 08 2004-L25 C/2003 Y3 19.979 17 55.0 -25 02 2004-L25 C/2003 Y4 20.729 17 58.8 -25 14 2004-L25 C/2003 Y5 22.771 18 08.5 -25 08 2004-L25 C/2003 Y6 23.571 18 14.3 -27 22 2004-L26 C/2003 Y7 24.638 18 20.0 -27 44 2004-L26 C/2003 Y8 25.288 18 19.6 -25 00 2004-L67 C/2003 Y9 25.479 18 20.7 -24 46 2004-L67 C/2003 Y10 26.064 18 23.5 -24 50 2004-L67

Battams, K.; Boschat, M.; Zhou, X.-M.; Hoffman, T.; Leprette, X.; Matson, R.; Kracht, R.; Sachs, J.; Marsden, B. G.; Kisala, R.

2004-06-01

240

Co-expression of metalloproteinases 11 and 12 in cervical scrapes cells from cervical precursor lesions  

PubMed Central

The metalloproteinases (MMP) 11 and 12 have been shown to be expressed in cervical cancer (CC). In order to extend our previous results, these MMPs were evaluated in cervical precursor lesions. One hundred seventeen cervical scrapes: thirty-six normal, thirty-six Low grade squamous lesions (LSIL), thirty-six High grade (HSIL), nine CC; and, also ninety-nine paraffin-embedded cervical lesions: fifteen normal cervices, thirty eight LSIL, sixteen HSIL, and five CC were collected. The samples were analyzed for relative expression by real time RT-PCR or immunohistochemistry assay. We were able to identify a relative increased expression of MMP11 in 75% and 78% from LSIL and HSIL samples, respectively. While MMP12 expression was 64% and 75% in LSIL and HSIL, respectively. Positive samples for MMP11 expression were also positive for MMP12 expression and also increased according to illness progression. In the tissues, MMP11 or MMP12 expression was observed in the cytoplasm of the neoplastic cells, while in the normal epithelium was absent. The reaction was always stronger for MMP12 than MMP11. MMP11 expression was present in 77% and 66% of LSIL and HSIL, while MMP12 expression was 73% and 68%. There was a relationship between MMP11 or MMP12 expression and HPV infection. Our data are showing a relationship between diagnostic of precursor lesions and the MMP11 and 12 expressions, suggesting that their expression could be an early event in the neoplastic lesions of the cervix and could have clinical significance.

Valdivia, Alejandra; Peralta, Raul; Matute-Gonzalez, Manuel; Garcia Cebada, Juan Manuel; Casasola, Ivonne; Jimenez-Medrano, Cristina; Aguado-Perez, Rogelio; Villegas, Vanessa; Gonzalez-Bonilla, Cesar; Manuel-Apolinar, Leticia; Ibanez, Miguel; Salcedo, Mauricio

2011-01-01

241

Structure of {sup 12}N using {sup 11}C+p resonance scattering  

SciTech Connect

The level structure of {sup 12}N has been investigated from 2.2 to 11.0 MeV in excitation energy using a {sup 11}C+p resonance interaction with thick targets and inverse kinematics. Excitation functions were fitted using an R-matrix approach. Sixteen levels in {sup 12}N were included in the analysis, several of them are new. Spin-parity assignments, excitation energies and widths are proposed for these levels.

Peraejaervi, K.; Powell, J. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Fu, Changbo; Chubarian, G.; Goldberg, V. Z.; Tabacaru, G.; Tang, X. D.; Tribble, R. E. [Texas A and M University, Cyclotron Institute, College Station, Texas 77843 (United States); Rogachev, G. V.; Volya, A. [Physics Department, Florida State University, Tallahassee, Florida 32306 (United States); Guo, F. Q.; Cerny, Joseph [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Department of Chemistry, University of California, Berkeley, California 94720 (United States); Lee, D. [Nuclear Science Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 (United States); Department of Nuclear Engineering, University of California, Berkeley, California 94720 (United States); Moltz, D. M. [Department of Chemistry, University of California, Berkeley, California 94720 (United States); Skorodumov, B. B. [University of Notre Dame, Notre Dame, Indiana 46556 (United States); Brown, B. A. [Michigan State University, East Lansing, Michigan 48824 (United States)

2006-08-15

242

Solar radiation scattered in the Venus atmosphere - The Venera 11, 12 data  

Microsoft Academic Search

Venera 11 and 12 probe measurements of scattered solar radiation in the Venus atmosphere are presented. The integral downward solar radiation flux toward the surface near the Venera 11 landing site was 78 W\\/sq m, and the value of the downward solar flux on the surface at the subsolar point, averaged over the data from several probes, is 90 +

V. I. Moroz; A. P. Ekonomov; Yu. M. Golovin; B. E. Moshkin; N. F. San'ko

1983-01-01

243

Crystallization and preliminary crystallographic analysis of human LR11 Vps10p domain  

PubMed Central

Low-density lipoprotein receptor (LDLR) relative with 11 binding repeats (LR11; also known as sorLA) is genetically associated with late-onset Alzheimer’s disease and is thought to be involved in neurodegenerative processes. LR11 contains a vacuolar protein-sorting 10 protein (Vps10p) domain. As this domain has been implicated in protein–protein interaction in other receptors, its structure and function are of great biological interest. Human LR11 Vps10p domain was expressed in mammalian cells and the purified protein was crystallized using the hanging-drop vapour-diffusion method. Enzymatic deglycosylation of the sample was critical to obtaining diffraction-quality crystals. Deglycosylated LR11 Vps10p-domain crystals belonged to the hexagonal space group P6122. A diffraction data set was collected to 2.4?Å resolution and a clear molecular-replacement solution was obtained.

Nakata, Zenzaburo; Nagae, Masamichi; Yasui, Norihisa; Bujo, Hideaki; Nogi, Terukazu; Takagi, Junichi

2011-01-01

244

The 16 CB11(CH3)n(CD3)(12-n)• radicals with 5-fold substitution symmetry: spin density distribution in CB11Me12(•).  

PubMed

The syntheses of all 16 CB(11)(CH(3))(n)(CD(3))(12-n)(•) radicals with 5-fold substitution symmetry are described. The variation in the width of their broad and featureless electron paramagnetic resonance signals as a function of the deuteriation pattern is used to deduce the relative values of the average hyperfine coupling constants a(H) of the hydrogen atoms in the ipso (1), ortho (2-6), meta (7-11), and para (12) methyl groups, a(H)(i):a(H)(o):a(H)(m):a(H)(p) = (0.18 ± 0.09):(0.71 ± 0.02):(1.00 ± 0.03):(0.52 ± 0.05), and these can be compared with ratios expected from a B3LYP/EPRII calculation, 0.04:0.55:1:0.51. PMID:22994310

Kaleta, Ji?í; Tarábek, Ján; Akdag, Akin; Pohl, Radek; Michl, Josef

2012-09-20

245

12 CFR 1237.10 - Limited-life regulated entities.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Limited-life regulated entities. 1237.10 Section 1237...CONSERVATORSHIP AND RECEIVERSHIP Limited-Life Regulated Entities § 1237.10 Limited-life regulated entities. (a) Status....

2013-01-01

246

12 CFR 745.10 - Accounts held by government depositors.  

Code of Federal Regulations, 2013 CFR

... 2013-01-01 2013-01-01 false Accounts held by government depositors. 745.10...APPENDIX Clarification and Definition of Account Insurance Coverage § 745.10 Accounts held by government depositors....

2013-01-01

247

12 CFR 652.10 - Investment management and requirements.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 2009-01-01 false Investment management and requirements. 652.10 Section...CORPORATION FUNDING AND FISCAL AFFAIRS Investment Management § 652.10 Investment management and requirements. (a)...

2009-01-01

248

12 CFR 652.10 - Investment management and requirements.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Investment management and requirements. 652.10 Section...CORPORATION FUNDING AND FISCAL AFFAIRS Investment Management § 652.10 Investment management and requirements. (a)...

2010-01-01

249

Comparison between the transverse responses of the reactions 12C(e,e'p)11B and 12C(gamma,p)11B  

Microsoft Academic Search

A study of the reaction 12C(e,e'p)11B in parallel kinematics has been made for the missing-momentum region 250

S. A. Morrow; J. Arneil; E. C. Aschenauer; M. F. van Batenburg; H. P. Blok; D. J. Boersma; D. Branford; T. Davinson; G. Demeyer; J. E. Ducret; W. H. Hesselink; D. Groep; K. Hicks; D. G. Ireland; N. Kalantar-Nayestanaki; L. Lapikás; M. Liang; J. MacKenzie; C. Marchand; R. Medaglia; J. Ryckebusch; M. van Sambeek; R. Starink; G. van der Steenhoven; M. A. van Uden; H. de Vries

2005-01-01

250

12 CFR 508.10 - Burden of persuasion.  

Code of Federal Regulations, 2013 CFR

... Banks and Banking 6 2013-01-01 2012-01-01 true Burden of persuasion. 508.10 Section 508.10 Banks...TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.10 Burden of...

2013-01-01

251

12 CFR 995.10 - Review of books and records.  

Code of Federal Regulations, 2013 CFR

...Banking 8 2013-01-01 2013-01-01 false Review of books and records. 995.10 Section 995.10 Banks...ENTITIES FINANCING CORPORATION OPERATIONS § 995.10 Review of books and records. The Finance Board shall...

2013-01-01

252

12 CFR 995.10 - Review of books and records.  

Code of Federal Regulations, 2010 CFR

...Banking 7 2010-01-01 2010-01-01 false Review of books and records. 995.10 Section 995.10 Banks...ENTITIES FINANCING CORPORATION OPERATIONS § 995.10 Review of books and records. The Finance Board shall...

2010-01-01

253

12 CFR 995.10 - Review of books and records.  

Code of Federal Regulations, 2010 CFR

...Banking 7 2009-01-01 2009-01-01 false Review of books and records. 995.10 Section 995.10 Banks...ENTITIES FINANCING CORPORATION OPERATIONS § 995.10 Review of books and records. The Finance Board shall...

2009-01-01

254

12 CFR 508.10 - Burden of persuasion.  

Code of Federal Regulations, 2010 CFR

... 5 2010-01-01 2010-01-01 false Burden of persuasion. 508.10 Section 508.10 Banks and Banking OFFICE...WHERE A CRIME IS CHARGED OR PROVEN § 508.10 Burden of persuasion. The petitioner has the burden of showing, by a...

2010-01-01

255

12 CFR 263.10 - Filing of papers.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Filing of papers. 263.10 Section 263.10 Banks and Banking...Practice and Procedure § 263.10 Filing of papers. (a) Filing. Any papers required to be filed, excluding documents...

2013-01-01

256

12 CFR 747.10 - Filing of papers.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Filing of papers. 747.10 Section 747.10 Banks and Banking...Practice and Procedure § 747.10 Filing of papers. (a) Filing. Any papers required to be filed, excluding documents...

2013-01-01

257

Complete Classification of (24,12) and (22,11) Self-Dual Codes.  

National Technical Information Service (NTIS)

A complete classification is given of all (22,11) and (24,12) self-dual codes. For each code the authors give the order of its group, the number of codes equivalent to it, and its weight distribution. There is a unique (24,12,6) self-dual code. Several th...

V. Pless N. J. A. Sloane

1974-01-01

258

10 CFR 1046.12 - Physical fitness training program.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Physical fitness training program. 1046...Force Personnel § 1046.12 Physical fitness training program. (a...who has not met the applicable physical fitness qualification standard,...

2010-01-01

259

10 CFR 1046.12 - Physical fitness training program.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 2009-01-01 false Physical fitness training program. 1046...Force Personnel § 1046.12 Physical fitness training program. (a...who has not met the applicable physical fitness qualification standard,...

2009-01-01

260

10 CFR 1046.12 - Physical fitness training program.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Physical fitness training program. 1046...OF ENERGY (GENERAL PROVISIONS) PHYSICAL PROTECTION OF SECURITY INTERESTS...Force Personnel § 1046.12 Physical fitness training program....

2013-01-01

261

10 CFR 1022.12 - Notice of proposed action.  

Code of Federal Regulations, 2013 CFR

...PROVISIONS) COMPLIANCE WITH FLOODPLAIN AND WETLAND ENVIRONMENTAL REVIEW REQUIREMENTS Procedures for Floodplain and Wetland Reviews § 1022.12 Notice of proposed... (a) For a proposed floodplain or wetland action for which an EIS is...

2013-01-01

262

Serum interleukin 10 and interleukin 11 in patients with acute pancreatitis  

PubMed Central

BACKGROUND—Proinflammatory and anti-inflammatory cytokines are involved in the pathogenesis of acute pancreatitis.?AIMS—To measure the serial serum levels of interleukin 10 and interleukin 11 in patients with acute pancreatitis and analyse the relation of these anti-inflammatory cytokines to disease severity.?METHODS—In 50 patients with acute pancreatitis, the serum concentrations of interleukin 10 and interleukin 11 were determined on days one, two, three, four, and seven after admission. Serum C reactive protein levels were evaluated on days one and two. Severity of pancreatitis was determined according to the Atlanta criteria.?RESULTS—Serum concentrations of interleukin 10 on days one to seven were significantly higher in patients with severe pancreatitis than in those with mild pancreatitis. Patients with severe attacks had significantly elevated serum interleukin 11 concentrations on days two to four compared with those with mild attacks, but not on days one and seven. With cut off levels of 30 pg/ml for interleukin 10, 10.5 pg/ml for interleukin 11, and 115 mg/l for C reactive protein, the accuracy rates for detecting severe pancreatitis were 84%, 64%, and 78% respectively on day one and 82%, 74%, and 84% respectively on day two.?CONCLUSIONS—Serum interleukin 10 and interleukin 11 concentrations reflect the severity of acute pancreatitis. Interleukin 10 is a useful variable for early prediction of the prognosis of acute pancreatitis.???Keywords: acute pancreatitis; C reactive protein; interleukin 10; interleukin 11

Chen, C; Wang, S; Lu, R; Chang, F; Lee, S

1999-01-01

263

Autoxidation of the furan fatty acid ester, methyl 9,12-epoxyoctadeca-9,11-dienoate  

Microsoft Academic Search

The objective of this study was to identify autoxidation products of methyl 9,12-epoxyoctadeca-9,11-dienoate (F9,12). Previous work has shown that F9,12 is a product both of autoxidation and singlet oxygen oxidation of the methyl ester derivative of conjugated linoleic acid\\u000a (CLA). F9,12, 95% pure, was synthesized from methyl ricinoleate. The synthetic F9,12 was heated at 50°C in sealed tubes containing air.

N. Sehat; M. P. Yurawecz; J. A. G. Roach; M. M. Mossoba; K. Eulitz; E. P. Mazzola; Y. Ku

1998-01-01

264

Structure of Rpn10 and Its Interactions with Polyubiquitin Chains and the Proteasome Subunit Rpn12*  

PubMed Central

Schizosaccharomyces pombe Rpn10 (SpRpn10) is a proteasomal ubiquitin (Ub) receptor located within the 19 S regulatory particle where it binds to subunits of both the base and lid subparticles. We have solved the structure of full-length SpRpn10 by determining the crystal structure of the von Willebrand factor type A domain and characterizing the full-length protein by NMR. We demonstrate that the single Ub-interacting motif (UIM) of SpRpn10 forms a 1:1 complex with Lys48-linked diUb, which it binds selectively over monoUb and Lys63-linked diUb. We further show that the SpRpn10 UIM binds to SpRpn12, a subunit of the lid subparticle, with an affinity comparable with Lys48-linked diUb. This is the first observation of a UIM binding other than a Ub fold and suggests that SpRpn12 could modulate the activity of SpRpn10 as a proteasomal Ub receptor.

Riedinger, Christiane; Boehringer, Jonas; Trempe, Jean-Francois; Lowe, Edward D.; Brown, Nicholas R.; Gehring, Kalle; Noble, Martin E. M.; Gordon, Colin; Endicott, Jane A.

2010-01-01

265

No evidence of an 11.16 MeV 2+ state in 12C  

NASA Astrophysics Data System (ADS)

An experiment using the 11B(3He,d)12C reaction was performed at iThemba LABS at an incident energy of 44 MeV and analyzed with a high energy-resolution magnetic spectrometer, to reinvestigate states in 12C published in 1971. The original investigation reported the existence of an 11.16 MeV state in 12C that displays a 2+ nature. In the present experiment, data were acquired at laboratory angles of 25?, 30?, and 35?, which is part of the center-of-mass (c.m.) angle range in the original measurements where a clear signature of such a state was observed. These new low-background measurements revealed no evidence of the previously reported state at 11.16 MeV in 12C.

Smit, F. D.; Nemulodi, F.; Buthelezi, Z.; Carter, J.; Fearick, R. W.; Förtsch, S. V.; Freer, M.; Fujita, H.; Jingo, M.; Kureba, C. O.; Mabiala, J.; Mira, J.; Neveling, R.; Papka, P.; Steyn, G. F.; Swartz, J. A.; Usman, I. T.; van Zyl, J. J.

2012-09-01

266

Microbial Production of Energy Colloquium- March 10-12, 2006  

SciTech Connect

The American Academy of Microbiology convened a colloquium March 10-12, 2006, in San Francisco, California, to discuss the production of energy fuels by microbial conversions. The status of research into various microbial energy technologies, the advantages and disadvantages of each of these approaches, research needs in the field, and education and training issues were examined, with the goal of identifying routes for producing biofuels that would both decrease the need for fossil fuels and reduce greenhouse gas emissions. Currently, the choices for providing energy are limited. Policy makers and the research community must begin to pursue a broader array of potential energy technologies. A diverse energy portfolio that includes an assortment of microbial energy choices will allow communities and consumers to select the best energy solution for their own particular needs. Funding agencies and governments alike need to prepare for future energy needs by investing both in the microbial energy technologies that work today and in the untested technologies that will serve the world’s needs tomorrow. More mature bioprocesses, such as ethanol production from starchy materials and methane from waste digestors, will find applications in the short term. However, innovative techniques for liquid fuel or biohydrogen production are among the longer term possibilities that should also be vigorously explored, starting now. Microorganisms can help meet human energy needs in any of a number of ways. In their most obvious role in energy conversion, microorganisms can generate fuels, including ethanol, hydrogen, methane, lipids, and butanol, which can be burned to produce energy. Alternatively, bacteria can be put to use in microbial fuel cells, where they carry out the direct conversion of biomass into electricity. Microorganisms may also be used some day to make oil and natural gas technologies more efficient by sequestering carbon or by assisting in the recovery of oil and natural gas from the subsurface. The participants discussed--key microbial conversion paths; overarching research issues; current funding models and microbial energy research; education, training, interdisciplinary cooperation and communication. Their recommendations are--Cellulose and lignocellulose are the preferred substrates for producing liquid transportation fuels, of which ethanol is the most commonly considered example. Generating fuels from these materials is still difficult and costly. A number of challenges need to be met in order to make the conversion of cellulose and lignocellulose to transportation fuels more cost-competitive. The design of hydrogen-producing bioreactors must be improved in order to more effectively manage hydrogen removal, oxygen exclusion, and, in the case of photobioreactors, to capture light energy more efficiently. Methane production may be optimized by fine-tuning methanogenic microbial communities. The ability to transfer electrons to an anode in a microbial fuel cell is probably very broadly distributed in the bacterial world. The scientific community needs a larger inventory of cultivated microorganisms from which to draw for energy conversion development. New and unusual organisms for manufacturing fuels and for use in fuel cells can be discovered using bioprospecting techniques. Particular emphasis should be placed on finding microbes, microbial communities, and enzymes that can enhance the conversion of lignocellulosic biomass to usable sugars. Many of the microbial processes critical to energy conversion are carried out by complex communities of organisms, and there is a need to better understand the community interactions that make these transformations possible. Better understanding of microbial community structure, robustness, networks, homeostasis, and cell-to-cell signaling is also needed. A better understanding of the basic enzymology of microorganisms is needed in order to move forward more quickly with microbial energy production. Research should focus on the actions of enzymes and enzyme complexes within the con

Merry Buckley; Judy Wall

2006-10-01

267

GENERAL VIEW OF WARD BUILDINGS, B11, B10, B9, AND NORTH ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GENERAL VIEW OF WARD BUILDINGS, B11, B10, B9, AND NORTH ELEVATION OF CONNECTING HALLWAY OF WARD C BUILDINGS, LOOKING WEST - Barnes General Hospital, East Fourth Plain Boulevard & O Street, Vancouver, Clark County, WA

268

National SBIR Phase III Commercialization Conference Held in Orlando, Florida on Jun 10 and 11, 1993.  

National Technical Information Service (NTIS)

The Small Business Innovation Research Phase III Conference, 10-11 June 1993, was organized to foster partnerships between the most successful SBIR firms and other small businesses, major corporations, venture capitalists, and technical representatives of...

1993-01-01

269

46 CFR 39.10-11 - Personnel training-TB/ALL.  

Code of Federal Regulations, 2012 CFR

... TANK VESSELS VAPOR CONTROL SYSTEMS General § 39.10-11 Personnel...transfer operation utilizing a vapor collection system must have completed a training program covering the particular system installed on the vessel....

2012-10-01

270

46 CFR 39.10-11 - Personnel training-TB/ALL.  

Code of Federal Regulations, 2011 CFR

... TANK VESSELS VAPOR CONTROL SYSTEMS General § 39.10-11 Personnel...transfer operation utilizing a vapor collection system must have completed a training program covering the particular system installed on the vessel....

2011-10-01

271

22 CFR 11.10 - Mid-level Foreign Service officer career candidate appointments. [Reserved  

Code of Federal Regulations, 2013 CFR

...Foreign Relations 1 2013-04-01 2013-04-01 false Mid-level Foreign Service officer career candidate appointments...PERSONNEL APPOINTMENT OF FOREIGN SERVICE OFFICERS § 11.10 Mid-level Foreign Service officer career candidate...

2013-04-01

272

Update on the Post-9/11 GI Bill. Report 09-12  

ERIC Educational Resources Information Center

|The Post-9/11 Veterans Educational Assistance Act of 2008, or Post-9/11 GI Bill, becomes effective August 1, 2009. The bill covers in-state graduate and undergraduate fees and vocational and technical training for veterans who served after September 10, 2001. Benefits are available for up to 36 months--equivalent to four academic years--and…

Angeli, Mallory

2009-01-01

273

12 CFR 1777.10 - Developments prompting supervisory response.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Developments prompting supervisory response...OVERSIGHT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SAFETY AND SOUNDNESS PROMPT...Supervisory Response § 1777.10 Developments prompting supervisory...

2012-01-01

274

12 CFR 1777.10 - Developments prompting supervisory response.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Developments prompting supervisory response...OVERSIGHT, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT SAFETY AND SOUNDNESS PROMPT...Supervisory Response § 1777.10 Developments prompting supervisory...

2013-01-01

275

12 CFR 760.10 - Notice of servicer's identity.  

Code of Federal Regulations, 2013 CFR

...Notice of servicer's identity. 760.10 Section... Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION...Notice of servicer's identity. (a) Notice requirement...designee) in writing of the identity of the servicer of...

2013-01-01

276

New chemistry of 1,2-closo-P2B10H10 and 1,2-closo-As2B10H10; in silico and gas electron diffraction structures, and new metalladiphospha- and metalladiarsaboranes.  

PubMed

The molecular structures of 1,2-closo-P(2)B(10)H(10) (1) and 1,2-closo-As(2)B(10)H(10) (2) have been determined by gas electron diffraction and the results obtained compared with those from computation at the MP2/6-31G** level of theory. The level of agreement is good for 2 (root-mean-square [rms] misfit for As and B atoms 0.0297 Å) and very good for 1 (rms misfit for P and B atoms 0.0082 Å). In comparing the structures of 1 and 2 with that of 1,2-closo-C(2)B(10)H(12) (I) it is evident that expansion of the polyhedron from I to 1 to 2 is restricted only to the heteroatom vertices and the B(6) face to which these are bound. Following deboronation (at B3) and subsequent metallation, compounds 1 and 2 have been converted into the new metalladiheteroboranes 3-(?-C(9)H(7))-3,1,2-closo-CoAs(2)B(9)H(9) (4), 3-(?-C(10)H(14))-3,1,2-closo-RuAs(2)B(9)H(9) (5), 3-(?-C(5)H(5))-3,1,2-closo-CoP(2)B(9)H(9) (6), 3-(?-C(9)H(7))-3,1,2-closo-CoP(2)B(9)H(9) (7) and 3-(?-C(10)H(14))-3,1,2-closo-RuP(2)B(9)H(9) (8), the last three constituting the first examples of metalladiphosphaboranes. Together with the known compound 3-(?-C(5)H(5))-3,1,2-closo-CoAs(2)B(9)H(9) (3), compounds 4-8 have been analysed by NMR spectroscopy and (except for 8) single-crystal X-ray diffraction. The (11)B NMR spectra of analogous pairs of metalladiphosphaborane and metalladiarsaborane (6 and 3, 7 and 4, 8 and 5) reveal a consistently narrower (9-10 ppm) chemical shift range for the metalladiarsaboranes, the combined result of a deshielding of the lowest frequency resonance (B6) and an increased shielding of the highest frequency resonance (B8) via an antipodal effect. In crystallographic studies, compounds 3 and 5B (one of two crystallographically-independent molecules) suffer As/B disorder, but in both cases it was possible to refine distinct, ordered, components of the disorder, the first time this has been reported for metalladiarsaboranes. Moreover, whilst the Cp compounds 6 and 3 are disordered, their indenyl analogues 7 and 4 are either ordered or significantly less disordered, a consequence of both the reduced symmetry of an indenyl ligand compared to a Cp ligand and the preference of the former for a distinct conformation relative to the cage heteroatoms. Unexpectedly, whilst this conformation in the cobaltadiphosphaborane 7 is cis-staggered (similar to that previously established for the analogous cobaltadicarborane), in the cobaltadiarsaborane 4 the conformation is close to cis-eclipsed. PMID:21666895

McLellan, R; Boag, N M; Dodds, K; Ellis, D; Macgregor, S A; McKay, D; Masters, S L; Noble-Eddy, R; Platt, N P; Rankin, D W H; Robertson, H E; Rosair, G M; Welch, A J

2011-06-10

277

Kinetic and crystallographic studies of extended-spectrum GES-11, GES-12, and GES-14 ?-lactamases.  

PubMed

GES-1 is a class A extended-spectrum ?-lactamase conferring resistance to penicillins, narrow- and expanded-spectrum cephalosporins, and ceftazidime. However, GES-1 poorly hydrolyzes aztreonam and cephamycins and exhibits very low k(cat) values for carbapenems. Twenty-two GES variants have been discovered thus far, differing from each other by 1 to 3 amino acid substitutions that affect substrate specificity. GES-11 possesses a Gly243Ala substitution which seems to confer to this variant an increased activity against aztreonam and ceftazidime. GES-12 differs from GES-11 by a single Thr237Ala substitution, while GES-14 differs from GES-11 by the Gly170Ser mutation, which is known to confer increased carbapenemase activity. GES-11 and GES-12 were kinetically characterized and compared to GES-1 and GES-14. Purified GES-11 and GES-12 showed strong activities against most tested ?-lactams, with the exception of temocillin, cefoxitin, and carbapenems. Both variants showed a significantly increased rate of hydrolysis of cefotaxime, ceftazidime, and aztreonam. On the other hand, GES-11 and GES-12 (and GES-14) variants all containing Ala243 exhibited increased susceptibility to classical inhibitors. The crystallographic structures of the GES-11 and GES-14 ?-lactamases were solved. The overall structures of GES-11 and GES-14 are similar to that of GES-1. The Gly243Ala substitution caused only subtle local rearrangements, notably in the typical carbapenemase disulfide bond. The active sites of GES-14 and GES-11 are very similar, with the Gly170Ser substitution leading only to the formation of additional hydrogen bonds of the Ser residue with hydrolytic water and the Glu166 residue. PMID:22908160

Delbrück, Heinrich; Bogaerts, Pierre; Kupper, Michaël B; Rezende de Castro, Roberta; Bennink, Sandra; Glupczynski, Youri; Galleni, Moreno; Hoffmann, Kurt M; Bebrone, Carine

2012-08-20

278

Genomic and Expression Analysis of the 8p11-12 Amplicon in Human Breast Cancer Cell Lines  

Microsoft Academic Search

Gene amplification is an important mechanism of oncogene activation in breast and other cancers. Characterization of amplified regions of the genome in breast cancer has led to the identification of important onco- genes including erbB-2\\/HER-2, C-MYC, and fibroblast growth factor re- ceptor (FGFR) 2. Chromosome 8p11-p12 is amplified in 10 -15% of human breast cancers. The putative oncogene FGFR1 localizes

Michael E. Ray; Zeng Quan Yang; Donna Albertson; Celina G. Kleer; Joseph G. Washburn; Jill A. Macoska; Stephen P. Ethier

2004-01-01

279

Thermodynamic Properties of B10H10(2-)(Aq) and B12H12(2-)(Aq).  

National Technical Information Service (NTIS)

The oxidation of B10H10(2-) to boric acid by permanganate in dilute aqueous solution was studied calorimetrically, and the resulting standard enthalpy of formation of the aqueous polyhedral ion at 25C is +22 plus or minus 5 kcal/mol. This result and sever...

A. Kaczmarczyk T. B. Eames W. C. Nichols W. H. Stockmayer

1967-01-01

280

Ein 10 bit 10MS/s Low-Power AD-Converter in 0.11mm2  

NASA Astrophysics Data System (ADS)

Ein 10 bit 10MS/s Analog-Digital- Wandler mit niedriger Leistungaufnahme von 8,4mW wurde implementiert. Der geringe Flächenbedarf von 0,11mm2 macht diesen Wandler besonders geeignet f¨ur Multikanalanwendungen. Um die Anforderungen von 10 bit, 10 MS/s möglichst effizient zu erfüllen wurde eine zyklische Wandlerarchitektur gewählt, die in einem 0,18?m-CMOSProzess mit MIM-Kondensatoren implementiert wurde. Der entworfene ADC wurde in 21 parallelen Kanälen auf einem mixed-signal-Chip zusammen mit digitalen Filtern, vier RISC-CPUs und I/O-Schaltungen implementiert. A 10 bit 10MS/s Analog to Digital Converter, consuming a power of 8,4mW, has been implemented. Due to the small area of 0,11mm2 this ADC is highly suited for multichannel implementations. A cyclic converter architecture is best suited for this application, being implemented in a 0,18?m CMOS process with MIM-capacitors. The designed ADC was implemented in an array of 21 channels on a mixed signal chip together with digital filters, four RISC-CPUs and I/O circuitry.

Muthers, D.; Tielert, R.

2004-05-01

281

The Structure of 12N using 11C + p resonance scattering  

SciTech Connect

The level structure of {sup 12}N has been investigated from 2.2 to 11.0 MeV in excitation energy using a {sup 11}C + p resonance interaction with thick targets and inverse kinematics. Excitation functions were fitted using an R-matrix approach. Sixteen levels in {sup 12}N were included in the analysis, several of them are new. Spin-parity assignments, excitation energies and widths are proposed for these levels. To fit the high energy part of the excitation function, imaginary phase shifts had to be added to the phase shifts generated by the hard sphere scattering.

Perajarvi, K.; Chang, Bo Fu; Rogachev, G.V.; Chubarian, G.; Goldberg, V.Z.; Guo, Q.; Lee, D.; Moltz, D.M.; Powell, J.; Skorodumov,B.B.; Tabacaru, G.; Tang, X.D.; Tribble, R.E.; Brown, B.A.; Volya, A.; Cerny, Joseph

2006-03-02

282

Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens  

Microsoft Academic Search

Taxadiene synthase gene from Taxus brevifolia was constitutively expressed in the moss Physcomitrella patens using a ubiquitin promoter to produce taxa-4(5),11(12)-diene, the precursor of the anticancer drug paclitaxel. In stable\\u000a moss transformants, taxa-4(5),11(12)-diene was produced up to 0.05% fresh weight of tissue, without significantly affecting\\u000a the amounts of the endogenous diterpenoids (ent-kaurene and 16-hydroxykaurane). Unlike higher plants that had been

Aldwin Anterola; Erin Shanle; Pierre-François Perroud; Ralph Quatrano

2009-01-01

283

The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance  

Microsoft Academic Search

Antigen-presenting cells (APCs) induce T cell activation as well as T cell tolerance. The molecular basis of the regulation of this critical 'decision' is not well understood. Here we show that HDAC11, a member of the HDAC histone deacetylase family with no prior defined physiological function, negatively regulated expression of the gene encoding interleukin 10 (IL-10) in APCs. Overexpression of

Fengdong Cheng; Hong-Wei Wang; Ildelfonso Suarez; Michelle Glozak; Michelle Maurin; Danny Nguyen; Kenneth L Wright; Peter W Atadja; Kapil Bhalla; Javier Pinilla-Ibarz; Edward Seto; Alejandro Villagra; Eduardo M Sotomayor

2008-01-01

284

NQRS Data for C10H11BrOS (Subst. No. 1240)  

NASA Astrophysics Data System (ADS)

This document is part of Subvolume A `Substances Containing Ag … C10H15' of Volume 48 `Nuclear Quadrupole Resonance Spectroscopy Data' of Landolt-Börnstein - Group III `Condensed Matter'. It contains an extract of Section `3.2 Data tables' of the Chapter `3 Nuclear quadrupole resonance data' providing the NQRS data for C10H11BrOS (Subst. No. 1240)

Chihara, H.; Nakamura, N.

285

Biotransformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) by denitrifying Pseudomonas sp. strain FA1.  

PubMed

The microbial and enzymatic degradation of a new energetic compound, 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), is not well understood. Fundamental knowledge about the mechanism of microbial degradation of CL-20 is essential to allow the prediction of its fate in the environment. In the present study, a CL-20-degrading denitrifying strain capable of utilizing CL-20 as the sole nitrogen source, Pseudomonas sp. strain FA1, was isolated from a garden soil. Studies with intact cells showed that aerobic conditions were required for bacterial growth and that anaerobic conditions enhanced CL-20 biotransformation. An enzyme(s) involved in the initial biotransformation of CL-20 was shown to be membrane associated and NADH dependent, and its expression was up-regulated about 2.2-fold in CL-20-induced cells. The rates of CL-20 biotransformation by the resting cells and the membrane-enzyme preparation were 3.2 +/- 0.1 nmol h(-1) mg of cell biomass(-1) and 11.5 +/- 0.4 nmol h(-1) mg of protein(-1), respectively, under anaerobic conditions. In the membrane-enzyme-catalyzed reactions, 2.3 nitrite ions (NO(2)(-)), 1.5 molecules of nitrous oxide (N(2)O), and 1.7 molecules of formic acid (HCOOH) were produced per reacted CL-20 molecule. The membrane-enzyme preparation reduced nitrite to nitrous oxide under anaerobic conditions. A comparative study of native enzymes, deflavoenzymes, and a reconstituted enzyme(s) and their subsequent inhibition by diphenyliodonium revealed that biotransformation of CL-20 is catalyzed by a membrane-associated flavoenzyme. The latter catalyzed an oxygen-sensitive one-electron transfer reaction that caused initial N denitration of CL-20. PMID:12957905

Bhushan, Bharat; Paquet, Louise; Spain, Jim C; Hawari, Jalal

2003-09-01

286

Biotransformation of 2,4,6,8,10,12-Hexanitro-2,4,6,8,10,12-Hexaazaisowurtzitane (CL-20) by Denitrifying Pseudomonas sp. Strain FA1  

PubMed Central

The microbial and enzymatic degradation of a new energetic compound, 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20), is not well understood. Fundamental knowledge about the mechanism of microbial degradation of CL-20 is essential to allow the prediction of its fate in the environment. In the present study, a CL-20-degrading denitrifying strain capable of utilizing CL-20 as the sole nitrogen source, Pseudomonas sp. strain FA1, was isolated from a garden soil. Studies with intact cells showed that aerobic conditions were required for bacterial growth and that anaerobic conditions enhanced CL-20 biotransformation. An enzyme(s) involved in the initial biotransformation of CL-20 was shown to be membrane associated and NADH dependent, and its expression was up-regulated about 2.2-fold in CL-20-induced cells. The rates of CL-20 biotransformation by the resting cells and the membrane-enzyme preparation were 3.2 ± 0.1 nmol h?1 mg of cell biomass?1 and 11.5 ± 0.4 nmol h?1 mg of protein?1, respectively, under anaerobic conditions. In the membrane-enzyme-catalyzed reactions, 2.3 nitrite ions (NO2?), 1.5 molecules of nitrous oxide (N2O), and 1.7 molecules of formic acid (HCOOH) were produced per reacted CL-20 molecule. The membrane-enzyme preparation reduced nitrite to nitrous oxide under anaerobic conditions. A comparative study of native enzymes, deflavoenzymes, and a reconstituted enzyme(s) and their subsequent inhibition by diphenyliodonium revealed that biotransformation of CL-20 is catalyzed by a membrane-associated flavoenzyme. The latter catalyzed an oxygen-sensitive one-electron transfer reaction that caused initial N denitration of CL-20.

Bhushan, Bharat; Paquet, Louise; Spain, Jim C.; Hawari, Jalal

2003-01-01

287

Summary of Synoptic Meteorological Observations. Indonesian Coastal Marine Areas. Volume 2. Area 8 - West Borneo, Area 9 - Karimata Strait, Area 10 - Southwest Java Sea, Area 11 - South Central Java, Area 12 - Southeast Java, Area 13 - Southeast Java Sea, Area 14 - Northeast Java Sea.  

National Technical Information Service (NTIS)

The data contained in these tables were obtained from tape data Family 11 (TDF - 11), Marine Surface observations. TDF - 11 was primarily funded by the Naval Weather Service Command and selected by NWSD Asheville as the most comprehensive collection of ma...

1975-01-01

288

Oxidative biotransformation of farnesol and 10,11-epoxyfarnesol by fungal strains  

Microsoft Academic Search

The biotransformation of farnesol (1), 10,11-epoxyfarnesol (2), geranylacetone (3) and 9,10-epoxygeranylacetone (4) was investigated using four strains of microorganisms selected in the screening procedure. The substrates were transformed by Fusarium culmorum, Botrytis cinerea, Rhodotorula rubra, Rhodotorula marina into oxyderivatives of geranylacetone. The biotransformation of farnesol after 2 days incubation with F. culmorum afforded mainly 8-hydroxygeranylacetone (5) and 9,10-epoxygeranylacetone (3) with

Anna Gliszczy?ska; Czes?aw Wawrze?czyk

2008-01-01

289

Angular distributions of four proton groups from the b10(d, p)b11 reaction  

Microsoft Academic Search

Angular distributions have been measured of four proton groups from the B10(d, p)B11 reaction corresponding to transitions to the groundstate (group (0)) and the three lowest excited states of B11 (groups (1), (2) and (3)). A thin target of natural boron was bombarded with 310 keV deuterons and protons were detected by nuclear emulsions placed at 15 ° intervals round

P. M. Endt; C. H. Paris; H. M. Jongerius; F. P. G. Valckx

1952-01-01

290

Australian Chemistry Test Item Bank: Years 11 and 12. Volume 2.  

ERIC Educational Resources Information Center

|The second volume of the Australian Chemistry Test Item Bank, consisting of two volumes, contains nearly 2000 multiple-choice items related to the chemistry taught in Year 11 and Year 12 courses in Australia. Items which were written during 1979 and 1980 were initially published in the "ACER Chemistry Test Item Collection" and in the "ACER…

Commons, C., Ed.; Martin, P., Ed.

291

An Experiment on Impatiens New Guinea for 11-12 Year Olds  

ERIC Educational Resources Information Center

|The following experiment describes an easy experiment for children 11-12 years old, performed during spring in a compulsory school near Karlstad, Sweden. Four different ripe fruits were placed under flowering plants of Impatiens New Guinea (Impatiens hawkeri) for four days on a table and with plastic bags around both plants and fruits. For one of…

McEwan, Birgitta

2008-01-01

292

Armed Services Vocational Aptitude Battery: Development of Forms 11, 12, and 13. Volume 2.  

National Technical Information Service (NTIS)

This report describes the development of the Armed Services Vocational Aptitude Battery (ASVAB) Forms 11, 12, and 13. The items for the new forms were supplied by the Air Force Human Resources Laboratory (AFHRL). They were administered to examinees in Rec...

J. S. Prestwood C. D. Vale R. H. Massey J. R. Welsh

1985-01-01

293

40 CFR 180.1086 - 3,7,11-Trimethyl-1,6,10-dodecatriene-1-ol and 3,7,11-trimethyl-2,6,10-dodecatriene-3-ol...  

Code of Federal Regulations, 2013 CFR

...and 3,7,11-trimethyl-2,6,10-dodecatriene-3-ol; exemption from the requirement of a tolerance. The insect pheromone containing the active ingredients 3,7,11-trimethyl-1,6,10-dodecatriene-1-ol and...

2013-07-01

294

A compact laser-pumped Rb clock with 5×10?13 ??1\\/2 frequency stability  

Microsoft Academic Search

We have realized a compact, laser-pumped Rb atomic frequency standard in view of next generation space applications. The clock's Physics Package has a volume of 1.1 liters, and includes a frequency-stabilized diode laser and 2 clock resonator packages. The measured clock short-term stability is 5x10 -13 ? -1\\/2 , reaching < 3x10 -14 at ? > 20'000s. The typical clock

C. Affolderbach; F. Gruet; R. Matthey; G. Mileti

2011-01-01

295

Study of the Unstable Nucleus {sup 10}Li in Stripping Reactions of the Radioactive Projectiles {sup 11}Be and {sup 11}Li  

SciTech Connect

Reactions of the halo systems {sup 11}Be and {sup 11}Li (at 460 and 280 MeV/nucleon) with a carbon target demonstrate that ({ital n}+{sup 9}Li) has an (unbound) {ital l}=0 ground state very close to the threshold. The neutron halo of {sup 11}Li has appreciable (1{ital s}{sub 1/2}){sup 2} and (0{ital p}{sub 1/2}){sup 2} components.

Zinser, M.; Humbert, F.; Nilsson, T.; Schwab, W.; Blaich, T.; Borge, M.J.G.; Chulkov, L.V.; Eickhoff, H.; Elze, T.W.; Emling, H.; Franzke, B.; Freiesleben, H.; Geissel, H.; Grimm, K.; Guillemaud-Mueller, D.; Hansen, P.G.; Holzmann, R.; Irnich, H.; Jonson, B.; Keller, J.G.; Klepper, O.; Klingler, H.; Kratz, J.V.; Kulessa, R.; Lambrecht, D.; Leifels, Y.; Magel, A.; Mohar, M.; Mueller, A.C.; Muenzenberg, G.; Nickel, F.; Nyman, G.; Richter, A.; Riisager, K.; Scheidenberger, C.; Schrieder, G.; Sherrill, B.M.; Simon, H.; Stelzer, K.; Stroth, J.; Tengblad, O.; Trautmann, W.; Wajda, E.; Zude, E. [Gesellschaft fuer Schwerionenforschung, D-64291 Darmstadt (Germany)]|[Institut fuer Kernphysik, Technische Hochschule, D-64289 Darmstadt (Germany)]|[Fysiska Institutionen, Chalmers Tekniska Hoegskola, S-41296 Goeteborg (Sweden)]|[Institut fuer Kernchemie, Johannes-Gutenberg-Universitaet, D-55099 Mainz (Germany)]|[Instituto Estructura de la Materia, CSIC, E-28006 Madrid (Spain)]|[Russian Scientific Center ``Kurchatov Institute``, Institute of General and Nuclear Physics, Moscow 123182 (Russian Federation)]|[Institut fuer Kernphysik, Johann-Wolfgang-Goethe-Universitaet, D-60486 Frankfurt (Germany)]|[Institut fuer Experimentalphysik, Ruhr-Universitaet Bochum, D-44780 Bochum (Germany)]|[Institut de Physique Nucleaire, IN2P3-CNRS, F-91406 Orsay Cedex (France)]|[Institut for Fysik og Astronomi, Aarhus Universitet, DK-8000 Aarhus C (Denmark)]|[Institute of Physics, Jagellonian University, PL-30-059 (Poland)]|[Michigan State University, East Lansing, Michigan 48824-1321 (United State

1995-08-28

296

46 CFR 52.25-10 - Organic fluid vaporizer generators (modifies PVG-1 through PVG-12).  

Code of Federal Regulations, 2012 CFR

...2012-10-01 2012-10-01 false Organic fluid vaporizer generators (modifies...Other Boiler Types § 52.25-10 Organic fluid vaporizer generators (modifies PVG-1 through PVG-12). (a) Organic fluid vaporizer generators...

2012-10-01

297

Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12  

SciTech Connect

Chick contactin/F11 (also known as F3 in mouse) is a neuronal cell adhesion molecule of the immunoglobulin (Ig) gene family that is implicated in playing a role in the formation of axon connections in the developing nervous system. In human brain, contactin was first identified by amino terminal and peptide sequencing of the lentil-lectin-binding glycoprotein Gp135. The authors now report the isolation and characterization of cDNA clones encoding human contactin. Human contactin is composed of six C2 Ig-domains and four fibronectin type III (FNIII) repeats and is anchored to the membrane via a glycosyl phosphatidylinositol moiety, as shown by PI-PLC treatment of cells transfected with contactin cDNA and metabolic labeling with [{sup 3}H]-ethanolamine. At the amino acid level, h-contactin is 78% identical to chick contactin/F11 and 94% to mouse F3. Independent cDNAs encoding two putative contactin 1 cDNA encodes a protein with the amino-terminal sequence of purified Gp135, while the putative h-contactin 2 gene has a deletion of 33 nucleotides that predicts a protein with a shortened amino terminus. Northern analysis with a probe common for both isoforms detects one mRNA species of approximately 6.6 kb in adult human brain. Fluorescence in situ hybridization maps the gene for human contactin to human chromosome 12q11-q12. The h-contactin gene locus is thus in close proximity to homeobox 3, integrin subunit {alpha}5, several proto-oncogene genes, a chromosomal breakpoint associated with various tumors, and the gene locus for Stickler syndrome. The cloning of human contactin now permits the study of its role in disorder of the human nervous system. 56 refs., 6 figs., 1 tab.

Berglund, E.O.; Ranscht, B. [La Jolla Cancer Research Foundation, CA (United States)

1994-06-01

298

The pioneer 10 and 11 lessons for a mission to test the pioneer anomaly  

Microsoft Academic Search

Analysis of the radio-metric tracking data from the Pioneer 10\\/11 spacecraft at distances between 20-70 astronomical units (AU) from the Sun has consistently indicated the presence of an anomalous, small, constant Doppler frequency drift. The drift is a blue-shift, uniformly changing with rate a{sub t} = (2.92 {+-} 0.44) x 10¹ s\\/s². It can also be interpreted as a constant

S. G. Turyshev; Michael Martin Nieto; J. D. Anderson

2004-01-01

299

Lessons learned from the Pioneers 10\\/11 for a mission to test the Pioneer anomaly  

Microsoft Academic Search

Analysis of the radio-metric tracking data from the Pioneer 10\\/11 spacecraft at distances between 20 and 70 astronomical units (AU) from the Sun has consistently indicated the presence of an anomalous, small, constant Doppler frequency drift. The drift is a blue-shift, uniformly changing with rate ˜6 · 10-9 Hz\\/s. It can also be interpreted as a constant acceleration of aP

Slava G. Turyshev; Michael Martin Nieto; John D. Anderson

2007-01-01

300

Use of Be10 in polar ice to trace the 11-year cycle of solar activity  

Microsoft Academic Search

It is shown here that Be-10 concentrations in polar ice can be used to study variations in the solar activity in time periods predating historical records, especially the 11-year cycle. Results for the period 1783-1985 are shown which demonstrate an anticorrelation between Be-10 and the sunspot number. This finding opens up the possibility of studying the long-term behavior of solar

J. Beer; A. Blinov; G. Bonani; H. J. Hofmann; R. C. Finkel; B. Lehmann; H. Oeschger; A. Sigg; J. Schwander; T. Staffelbach; B. Stauffer; M. Suter; W. Wötfli

1990-01-01

301

Single-dose kinetics and metabolism of carbamazepine-10,11-epoxide  

Microsoft Academic Search

Carbamazepine-(CBZ)-10,11-epoxide (CBZ-E) was found to decompose in gastric juice in vitro. An antacid did not affect the bioavailability of single CBZ doses given to three subjects and was therefore used to neutralize gastric juice when administering CBZ-E. CBZ-E was given orally as a suspension in two single doses ranging from 10 to 200 mg to each of four healthy subjects.

Torbjörn Tomson; Gunnel Tybring; Leif Bertilsson

1983-01-01

302

11 CFR 100.9 - Commission (2 U.S.C. 431(10)).  

Code of Federal Regulations, 2013 CFR

11 Ç Federal Elections Ç 1 Ç 2013-01-01 Ç 2012-01-01 Ç true Ç Commission (2 U.S.C. 431(10 Ç 100.9 Ç Section 100.9 Ç Federal Elections Ç FEDERAL ELECTION COMMISSION Ç GENERAL Ç SCOPE AND DEFINITIONS (2 U.S.C. 431) Ç General Definitions Ç Â§ 100.9 Ç Commission (2 U.S.C. 431(10 Ç Commission Ç means...

2013-01-01

303

Preparation, separation, and confirmation of the eight geometrical cis\\/trans conjugated linoleic acid isomers 8,10-through 11,13–18?2  

Microsoft Academic Search

Conjugated linoleic acid (CLA) mixtures were isomerized with p-toluenesulfinic acid or I2 catalyst. The resultant mixtures of the eight cis\\/trans geometric isomers of 8,10-, 9,11-, 10,12-, and 11,13-octadecadienoic (18?2) acid methyl esters were separated by silver ion-high-performance\\u000a liquid chromatography (Ag+-HPLC) and gas chromatography (GC). Ag+-HPLC allowed the separation of all positional CLA isomers and geometric cis\\/trans CLA isomers except 10,12–18?2.

Klaus Eulitz; Martin P. Yurawecz; Najibullah Sehat; Jan Fritsche; John A. G. Roach; Magdi M. Mossoba; John K. G. Kramer; Richard O. Adlof; Yuoh Ku

1999-01-01

304

76 FR 45211 - Airworthiness Directives; Honeywell International Inc. TPE331-10 and TPE331-11 Series Turboprop...  

Federal Register 2010, 2011, 2012, 2013

...2009-NE-18-AD] Airworthiness Directives; Honeywell International Inc. TPE331-10 and TPE331-11...directive (AD) supersedure, applicable to Honeywell International Inc. TPE331-10 and TPE331-11...Page 45212

2011-07-28

305

AzTEC 1.1 mm OBSERVATIONS OF THE MBM12 MOLECULAR CLOUD  

SciTech Connect

We present 1.1 mm observations of the dust continuum emission from the MBM12 high-latitude molecular cloud observed with the Astronomical Thermal Emission Camera (AzTEC) mounted on the James Clerk Maxwell Telescope on Mauna Kea, Hawaii. We surveyed 6.34 deg{sup 2} centered on MBM12, making this the largest area that has ever been surveyed in this region with submillimeter and millimeter telescopes. Eight secure individual sources were detected with a signal-to-noise ratio of over 4.4. These eight AzTEC sources can be considered to be real astronomical objects compared to the other candidates based on calculations of the false detection rate. The distribution of the detected 1.1 mm sources or compact 1.1 mm peaks is spatially anti-correlated with that of the 100 {mu}m emission and the {sup 12}CO emission. We detected the 1.1 mm dust continuum emitting sources associated with two classical T Tauri stars, LkH{alpha}262 and LkH{alpha}264. Observations of spectral energy distributions (SEDs) indicate that LkH{alpha}262 is likely to be Class II (pre-main-sequence star), but there are also indications that it could be a late Class I (protostar). A flared disk and a bipolar cavity in the models of Class I sources lead to more complicated SEDs. From the present AzTEC observations of the MBM12 region, it appears that other sources detected with AzTEC are likely to be extragalactic and located behind MBM12. Some of these have radio counterparts and their star formation rates are derived from a fit of the SEDs to the photometric evolution of galaxies in which the effects of a dusty interstellar medium have been included.

Kim, M. J.; Kim, S.; Youn, S.; Kang, Y.-W. [Department of Astronomy and Space Science, Sejong University, KwangJin-gu, KunJa-dong 98, Seoul 143-747 (Korea, Republic of); Yun, M. S.; Wilson, G. W. [Department of Astronomy, University of Massachusetts, 710 North Pleasant St., Amherst, MA 01003 (United States); Aretxaga, I.; Hughes, D. H.; Humphrey, A. [Instituto Nacional de Astrofisca, Optica y Electronica, Tonantzintla, Puebla (Mexico); Williams, J. P. [Institute for Astronomy, University of Hawaii, 2680 Woodlawn Drive, Honolulu, HI 96822 (United States); Austermann, J. E. [Department of Astrophysical and Planetary Sciences, University of Colorado, Boulder, Colorado 80309 (United States); Perera, T. A. [Department of Physics, Illinois Wesleyan University, Bloomington, IL 61701 (United States); Mauskopf, P. D. [School of Physics and Astronomy, Cardiff University, Cardiff CF24 3AA (United Kingdom); Magnani, L., E-mail: sek@sejong.ac.kr [Department of Physics and Astronomy, The University of Georgia, Athens, GA 30602-2451 (United States)

2012-02-10

306

AzTEC 1.1 mm Observations of the MBM12 Molecular Cloud  

NASA Astrophysics Data System (ADS)

We present 1.1 mm observations of the dust continuum emission from the MBM12 high-latitude molecular cloud observed with the Astronomical Thermal Emission Camera (AzTEC) mounted on the James Clerk Maxwell Telescope on Mauna Kea, Hawaii. We surveyed 6.34 deg2 centered on MBM12, making this the largest area that has ever been surveyed in this region with submillimeter and millimeter telescopes. Eight secure individual sources were detected with a signal-to-noise ratio of over 4.4. These eight AzTEC sources can be considered to be real astronomical objects compared to the other candidates based on calculations of the false detection rate. The distribution of the detected 1.1 mm sources or compact 1.1 mm peaks is spatially anti-correlated with that of the 100 ?m emission and the 12CO emission. We detected the 1.1 mm dust continuum emitting sources associated with two classical T Tauri stars, LkH?262 and LkH?264. Observations of spectral energy distributions (SEDs) indicate that LkH?262 is likely to be Class II (pre-main-sequence star), but there are also indications that it could be a late Class I (protostar). A flared disk and a bipolar cavity in the models of Class I sources lead to more complicated SEDs. From the present AzTEC observations of the MBM12 region, it appears that other sources detected with AzTEC are likely to be extragalactic and located behind MBM12. Some of these have radio counterparts and their star formation rates are derived from a fit of the SEDs to the photometric evolution of galaxies in which the effects of a dusty interstellar medium have been included.

Kim, M. J.; Kim, S.; Youn, S.; Yun, M. S.; Wilson, G. W.; Aretxaga, I.; Williams, J. P.; Hughes, D. H.; Humphrey, A.; Austermann, J. E.; Perera, T. A.; Mauskopf, P. D.; Magnani, L.; Kang, Y.-W.

2012-02-01

307

Social inequalities and health among children aged 10–11 in The Netherlands: Causes and consequences  

Microsoft Academic Search

Socioeconomic health differences (SEHD) are relatively small in childhood. In adolescence they almost seem to disappear and among young adults they re-emerge. This article deals with mechanisms that contribute to the emergence of health differences by studying a group of 10–11 year old children in The Netherlands (n = 908). The role of determinants of health in the relation between

Fons van der Lucht; Johan Groothoff

1995-01-01

308

Performance of Vacuum Components Operating at 1 X 10 exp -11 Torr.  

National Technical Information Service (NTIS)

The Intersecting Storage Accelerator, ISABELLE, consists of two rings having a circumference of 3.8 km each. The vacuum system uses an 8.8 cm circular chamber maintained at 1 x 10 exp -11 torr by a combination of Ti sublimation and 30 liters/sec exp -1 io...

H. J. Halama

1978-01-01

309

Thai Grade 10 and 11 Students' Conceptual Understanding and Ability to Solve Stoichiometry Problems  

ERIC Educational Resources Information Center

|Stoichiometry and related concepts are an important part of student learning in chemistry. In this interpretive-based inquiry, we investigated Thai Grade 10 and 11 students' conceptual understanding and ability to solve numerical problems for stoichiometry-related concepts. Ninety-seven participants completed a purpose-designed survey instrument…

Dahsah, Chanyah; Coll, Richard K.

2007-01-01

310

11 CFR 9004.10 - Sale of assets acquired for fundraising purposes.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Sale of assets acquired for fundraising purposes...PAYMENTS; USE OF PAYMENTS § 9004.10 Sale of assets acquired for fundraising purposes...application of 11 CFR 9005.2(b). (b) Sale after end of expenditure report...

2012-01-01

311

Thai Grade 10 and 11 Students' Understanding of Stoichiometry and Related Concepts  

ERIC Educational Resources Information Center

The research reported in this case study explores the understanding of stoichiometry and related concepts of Thai science students in grades 10 and 11 after major national curriculum reforms. Students' conceptions and alternative conceptions were investigated using a questionnaire--the "Stoichiometry Concept Questionnaire" (SCQ) (N = 97), which…

Dahsah, Chanyah; Coll, Richard Kevin

2008-01-01

312

Selectability of Print Materials in Support of the Grades 10 and 11 Social Studies Curriculum.  

ERIC Educational Resources Information Center

This project report critiques library print materials used to support grades 10 and 11 social studies curriculum in British Columbia. The data collected are intended to provide a ready reference for school librarians when considering the particular print materials listed. Four criteria were used: readability, format and style, organization, and…

Yearwood, D. B.; Yearwood, E. I.

313

Easy Growth Experiment on Peas Stimulates Interest in Biology for 10-11 Year Old Pupils  

ERIC Educational Resources Information Center

|How do we support the enthusiasm children show for biology in school? Unfortunately, lack of exciting practical work and boring biology lessons seem to make science less popular. As a senior lecturer in plant physiology at Karlstad University I have simplified experiments intended for students at university and then tested them on 10-11 year old…

McEwen, Birgitta

2007-01-01

314

DIETARY T10, C-12-CONJUGATED LINOLEIC ACID REDUCES THE EXPRESSION OF FATTY ACID OXIDATION AND DRUG DETOXIFICATION ENZYMES IN MOUSE LIVER  

Technology Transfer Automated Retrieval System (TEKTRAN)

Mice fed diets containing t10, c12-CLA develop fatty livers and the role of hepatic fatty acid oxidation enzymes in this development is not well defined. We examined the effects of dietary c9, t11-CLA and t10, c12-CLA on the expression of hepatic genes for fatty acid metabolism. Eight week old, fema...

315

Water levels in wells J-11 and J-12, 1989-91, Yucca Mountain Area, Nevada  

SciTech Connect

Water levels have been measured in the Yucca Mountain area, Nevada, since 1981 in order to gain a better understanding of the ground-water flow system in the area. Water levels in wells J-11 and J-12 have been periodically measured using calibrated reeled steel tapes since 1989, however, calculation of water-level altitude was not possible prior to 1993 due to missing reference elevations. These elevations were determined in 1993 by the U.S. Geological Survey. During 1989-91, water-level altitudes for well J-11 ranged from 732.09 to 732.40 meters and the mean water-level altitude was 732.19 meters. During 1989-91, water-level altitudes for well J-12 ranged from 727.84 to 728.03 meters, and the mean water-level altitude was 727.95 meters.

Boucher, M.S.

1994-12-31

316

Water levels in wells J-11 and J-12, 1989-91, Yucca Mountain area, Nevada  

USGS Publications Warehouse

Water levels have been measured in the Yucca Mountain area, Nevada, since 1981 in order to gain a better understanding of the gound-water flow system in the area. Water level in wells J-11 and J-12 have been periodically measured using calibrated reeled steel tapes since 1989, however, calculation of water-level altitude was not possible prior to 1993 due to missing reference elevations. These elevations were determined in 1993 by the U.S. Geological Survey. During 1989-91, water-level altitudes for well J-11 ranged from 732.09 to 732.40 meters and the mean water-level altitude was 732.19 meters. During 1989-91, water-level altitudes for well J-12 ranged from 727.84 to 728.03 meters, and the mean water-level altitude was 727.95 meters.

Boucher, Michelle S.

1994-01-01

317

Lessons learned from the Pioneers 10\\/11 for a mission to test the Pioneer anomaly  

Microsoft Academic Search

Analysis of the radio-metric tracking data from the Pioneer 10\\/11 spacecraft at distances between 20 and 70 astronomical units (AU) from the Sun has consistently indicated the presence of an anomalous, small, constant Doppler frequency drift. The drift is a blue-shift, uniformly changing with rate ?6·10?9Hz\\/s. It can also be interpreted as a constant acceleration of aP=(8.74±1.33)×10?8 cm\\/s2 directed towards

Slava G. Turyshev; Michael Martin Nieto; John D. Anderson

2007-01-01

318

Genomic and expression analysis of the 8p11-12 amplicon in human breast cancer cell lines.  

PubMed

Gene amplification is an important mechanism of oncogene activation in breast and other cancers. Characterization of amplified regions of the genome in breast cancer has led to the identification of important oncogenes including erbB-2/HER-2, C-MYC, and fibroblast growth factor receptor (FGFR) 2. Chromosome 8p11-p12 is amplified in 10-15% of human breast cancers. The putative oncogene FGFR1 localizes to this region; however, we show evidence that FGFR inhibition fails to slow growth of three breast cancer cell lines with 8p11-p12 amplification. We present a detailed analysis of this amplicon in three human breast cancer cell lines using comparative genomic hybridization, traditional Southern and Northern analysis, and chromosome 8 cDNA microarray expression profiling. This study has identified new candidate oncogenes within the 8p11-p12 region, supporting the hypothesis that genes other than FGFR1 may contribute to oncogenesis in breast cancers with proximal 8p amplification. PMID:14729606

Ray, Michael E; Yang, Zeng Quan; Albertson, Donna; Kleer, Celina G; Washburn, Joseph G; Macoska, Jill A; Ethier, Stephen P

2004-01-01

319

Multiple Interacting Oncogenes on the 8p11-p12 Amplicon in Human Breast Cancer  

Microsoft Academic Search

The 8p11-p12 genomic region is amplified in 15% of breast cancers and harbors several candidate oncogenes. However, functional evidence for a transforming role for these genes is lacking. We identified 21 genes from this region as potential oncogenes based on statistical association between copy number and expression. We further showed that three of these genes (LSM1, BAG4, and C8orf4) induce

Zeng Quan Yang; Katie L. Streicher; Michael E. Ray; Judith Abrams; Stephen P. Ethier

2006-01-01

320

CORRELATES OF PHYSICAL ACTIVITY IN 11-12-YEARS-OLD CHILDREN  

Microsoft Academic Search

The main objective of the project was to analyse physical activity and sports interests in 11-12-years-old children attending standard classes and sports classes, and to find out the principal correlates for leisure time physical activities that influence their life style. A total of 84 girls and 106 boys from the fifth grade (standard and sports classes) participated in the study.

Erik Sigmund; Filip Neuls; Krysztof Skalik

2000-01-01

321

Objectively assessed physical activity and weight status in Maltese 11–12 year-olds  

Microsoft Academic Search

The objectives of the study were to identify levels of physical activity and sedentary time and assess how they differ by weight status in Maltese boys and girls. Participants were 234 Maltese children aged 11–12 years, of which 187 (80%) provided complete data. Physical activity was assessed using accelerometry and weight status determined through gender-specific age-adjusted Body mass index (BMI).

Andrew Decelis; Russell Jago; Kenneth R. Fox

2012-01-01

322

Coherent Raman Spectra of the nu(1) Mode of 10BF3 and 11BF3  

SciTech Connect

High resolution (0.001cm-1) coherent anti-Stokes Raman spectroscopy (CARS) was used to directly examine the v1 symmetric stretching mode of the planar symmetric D3h molecules 10BF3 and 11BF3. Simulations of the spectra were done using v1 rovibrational parameters deduced from published infrared hot-band and difference-band studies and the close similarity to the observed CARS spectra confirms the validity of the infrared constants. No significant perturbations by Fermi resonance or Coriolis interactions with nearby states are observed, in marked contrast to the case of sulfur trioxide, a similar D3h molecule recently studied. In the harmonic approximation, the 10BF3 and 11BF3 v1 Q- branches would be identical since the isotopic substitution is at the center of mass but, interestingly, the v1 stretching frequency for 11BF3 is found to be 0.198 cm-1 higher than for the lighter 10BF3 isotopomer. This counterintuitive result is reproduced almost exactly (0.200 cm -1) by ab initio calculations (B3LYP/cc-pVTZ) that included evaluation of cubic and quartic forced constants and xij anharmonicity constants. The ab initio computations also predict to within 1% the ?B, ?C changes in the rotational constants in going from the ground state to the v1=1 vibrational level. The results illustrate nicely the complementary interplay of modern infrared, Raman, and ab initio methods in obtaining and analyzing rovibrational spectra.

Kirkpatrick, Robynne; Masiello, Tony; Weber, Alfons; Nibler, Joseph W.

2006-05-01

323

Stratospheric loss and atmospheric lifetimes of CFC-11 and CFC-12 derived from satellite observations  

NASA Astrophysics Data System (ADS)

The lifetimes of CFC-11 and CFC-12 have been evaluated using global observations of their stratospheric distributions from satellite-based instruments between the period 1992 and 2010. The CFC data sets are from the Cryogen Limb Array Etalon Spectrometer (CLAES), the Cryogenic Infrared Spectrometers and Telescopes for the Atmosphere (CRISTA-1 and CRISTA-2), the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS), and the Atmospheric Chemistry Experiment (ACE). Stratospheric loss rates were calculated using an ultraviolet radiative transfer code with updated cross section and solar irradiance data. Mean steady state lifetimes based on these observations are 50.3 ± 16.8 yr for CFC-11 and 106.9 ± 21.7 yr for CFC-12, which are in reasonable agreement with the most recent WMO Ozone Assessment recommendations but are somewhat longer by 12% and 7%, respectively. There are two major sources of error in calculating lifetimes using this method. One error source is due to uncertainties in tropical stratospheric measurements, particularly for CFC-11. Another large contribution to the error arises from uncertainties in the penetration of solar ultraviolet radiation at wavelengths between 185 and 220 nm, primarily in the tropical stratosphere between 20 and 35 km altitude.

Minschwaner, K.; Hoffmann, L.; Brown, A.; Riese, M.; Müller, R.; Bernath, P. F.

2012-11-01

324

Structure effects in the reactions 9,10,11Be+64Zn at the Coulomb barrier  

NASA Astrophysics Data System (ADS)

Elastic scattering and direct reactions have been studied for the collisions induced by the three Beryllium isotopes 9,10,11Be, on a medium mass 64Zn target at energies around the Coulomb barrier. The elastic scattering angular distributions, measured for the three systems at the same center of mass energy, were analyzed within the Optical Model and reaction cross-sections were deduced from optical model calculations. For the 11Be induced reaction the transfer/break-up angular distribution was also extracted.

Scuderi, V.; Di Pietro, A.; Acosta, L.; Amorini, F.; Borge, M. J. G.; Figuera, P.; Fisichella, M.; Fraile, L. M.; Gomez-Camacho, J.; Jeppesen, H.; Lattuada, M.; Martel, I.; Milin, M.; Musumarra, A.; Papa, M.; Pellegriti, M. G.; Perez-Bernal, F.; Raabe, R.; Randisi, G.; Rizzo, F.; Santonocito, D.; Scalia, G.; Tengblad, O.; Torresi, D.; Vidal, A. M.; Zadro, M.

2011-01-01

325

The ?_{12}+?_6-?_6 and ?_{11}-?_{12} Bands of ^{12}CH_3^{13}CH_3: a Frequency Analysis Including Data from the Four Lowest Vibrational States  

NASA Astrophysics Data System (ADS)

High-resolution infrared spectra of the ?_{12}+?_6-?_6 (around 820 cm^{-1}) and ?_{11}-?_{12} (around 370 cm^{-1}) bands of ^{12}CH_3^{13}CH_3 are assigned. Frequencies from these bands together with data from the ?_{12} and ?_5 fundamentals and the torsional bands were analysed in a 4-state fit to determine the torsion mediated Coriolis and Fermi interactions. As compared to normal ethane this lower symmetry isotopologue shows more complicated vibrational couplings. The combined data set includes more than 6800 frequencies and was fitted to within experimental accuracy using a 77-parameter Hamiltonian. The first determination of molecular parameters for the ?_{11} state of ^{12}CH_3^{13}CH_3 has been made and using this Hamiltonian we have provided lower state energies and partition functions between 100 and 330 K in increment of 10 K for planetary data analysis. A comparison with a 4-state fit of similar data for ^{12}CH_3^{12}CH_3 will be made. N. Moazzen-Ahmadi, J. Norooz Oliaee, and V.-M. Horneman, JQSRT, submitted.

Moazzen-Ahmadi, N.; Oliaee, J. Norooz; Horneman, V.-M.

2013-06-01

326

A Recessive Gene for Primary Vesicoureteral Reflux Maps to Chromosome 12p11-q13  

PubMed Central

Primary vesicoureteral reflux (pVUR) is one of the most common causes of pediatric kidney failure. Linkage scans suggest that pVUR is genetically heterogeneous with two loci on chromosomes 1p13 and 2q37 under autosomal dominant inheritance. Absence of pVUR in parents of affected individuals raises the possibility of a recessive contribution to pVUR. We performed a genome-wide linkage scan in 12 large families segregating pVUR, comprising 72 affected individuals. To avoid potential misspecification of the trait locus, we performed a parametric linkage analysis using both dominant and recessive models. Analysis under the dominant model yielded no signals across the entire genome. In contrast, we identified a unique linkage peak under the recessive model on chromosome 12p11-q13 (D12S1048), which we confirmed by fine mapping. This interval achieved a peak heterogeneity LOD score of 3.6 with 60% of families linked. This heterogeneity LOD score improved to 4.5 with exclusion of two high-density pedigrees that failed to link across the entire genome. The linkage signal on chromosome 12p11-q13 originated from pedigrees of varying ethnicity, suggesting that recessive inheritance of a high frequency risk allele occurs in pVUR kindreds from many different populations. In conclusion, this study identifies a major new locus for pVUR and suggests that in addition to genetic heterogeneity, recessive contributions should be considered in all pVUR genome scans.

Weng, Patricia L.; Sanna-Cherchi, Simone; Hensle, Terry; Shapiro, Ellen; Werzberger, Alan; Caridi, Gianluca; Izzi, Claudia; Konka, Anita; Reese, Adam C.; Cheng, Rong; Werzberger, Samuel; Schlussel, Richard N.; Burk, Robert D.; Lee, Joseph H.; Ravazzolo, Roberto; Scolari, Francesco; Ghiggeri, Gian Marco; Glassberg, Kenneth; Gharavi, Ali G.

2009-01-01

327

1.1 mm Observations of the MBM12 Molecular Cloud  

NASA Astrophysics Data System (ADS)

We present 1.1 mm observations of the dust continuum emission from the MBM12 high-latitude molecular cloud observed with the Astronomical Thermal Emission Camera (AzTEC) mounted on the James Clerk Maxwell Telescope (JCMT) on Mauna Kea, Hawaii. Eight secure individual sources were detected with over 4.4 signal-to-noise ratio. These eight AzTEC sources can be considered to be real astronomical objects compared to the other candidates based on calculations of the false detection rate (FDR). The distribution of the detected 1.1 mm sources or compact 1.1 mm peaks is spatially anti-correlated with that of the 100 microm emission and the CO emission. We detected the 1.1 mm dust continuum emitting sources associated with two classical T Tauri stars, LkHalpha 262 and LkHalpha 264. Observations of spectral energy distributions (SEDs) indicate that LkHalpha 262 is likely to be Class II (pre-main sequence star), but there are also indications that it could be a late Class I (protostar). A flared disk and a bipolar cavity in the models of Class I sources lead to more complicated SEDs. From the present AzTEC observations of the MBM12 region, it appears that other sources detected with AzTEC are likely to be extragalactic and located behind MBM12. Some of these have radio counterparts and their star-formation rates (SFRs) are derived from a fit of the SEDs to the photometric evolution of galaxies in which the effects of a dusty interstellar medium have been included. This research was supported in part by Mid-career Researcher Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology 2011-0028001.

Kim, Sungeun; Kim, M.; Youn, S.; Yun, M. S.; Wilson, G. W.; Aretxaga, I.; Williams, J. P.; Hughes, D. H.; Humphrey, A.; Austermann, J. E.; Perera, T. A.; Mauskopf, P. D.; Magnani, L.

2012-05-01

328

Del(12)(p11.21p12.2) associated with an asphyxiating thoracic dystrophy or chondroectodermal dysplasia-like syndrome  

SciTech Connect

We describe a 5-year-old Japanese boy who has some radiographic findings characteristic of asphyxiating thoracic dystrophy (ATD)-chondroectodermal dysplasia with a de novo chromosome abnormality. He also has mild mental retardation, short stature, hypoplastic hair and skin, oligodontia, small thoracic cage, hypoplastic pelvis and cone-shaped epiphyses of hands. On cytogenetic studies he was found to have a de novo del(12)(p11.21p12.2). These results suggest that the locus of the gene associated with ATD-chondroectodermal dysplasia may be situated at 12p11.21p12.2. 11 refs., 2 figs.

Nagai, T.; Kato, R.; Hasegawa, T. [Tokyo Metropolitan Kiyose Children`s Hospital (Japan)] [and others

1995-01-02

329

12 CFR 1301.10 - Requests for business information provided to the Council.  

Code of Federal Regulations, 2013 CFR

12 Banks and Banking 9 2013-01-01 2013-01-01...10 Section 1301.10 Banks and Banking FINANCIAL STABILITY OVERSIGHT COUNCIL FREEDOM...trade secrets or other commercial or financial information that may be...

2013-01-01

330

Star clusterings in the Carina complex: UBVRI photometry of Bochum 9, 10 and 11  

Microsoft Academic Search

We report on the first UBVRI CCD photometry of three poorly known star clusterings in the region of eta Carinae: Bochum 9, 10 and 11. We find that they are young, rather poor, loose open clusters. We argue that Bochum 9 is probably a small and loose open cluster with about 30 probable members having E(B-V)=0.63+\\/-0.08, located 4.6kpc far from

Ferdinando Patat; Giovanni Carraro

2001-01-01

331

Genistein enhances antigen-specific cytokine production in female DO11.10 transgenic mice.  

PubMed

Genistein is a phytoestrogen contained at high levels in soy products and has been shown to regulate immunoresponse. In this study, we evaluated the effects of genistein on the production of cytokines from antigen (Ag)-specific T cells using DO11.10 transgenic mice because the direct effect of genistein on Ag-specific cytokine production has not been elucidated. The oral administration of 20 mg/kg genistein increased IFN-gamma and IL-4 production from DO11.10+ T cells in response to ovalbumin (OVA)323-339 peptide in female DO11.10 mice. Analysis of intracellular cytokine synthesis revealed that the percentages of cytokine-producing cells in the control and genistein-treated groups were not different, indicating that increased cytokine production occurred at the single-cell level. In contrast to the female mice, genistein did not increase cytokine production in male mice, suggesting that the effect of genistein on cytokine production is gender-dependent. PMID:17190102

Sakai, Tohru; Kogiso, Mari; Mitsuya, Kaori; Komatsu, Tatsushi; Yamamoto, Shigeru

2006-10-01

332

The apparent anomalous, weak, long-range acceleration of Pioneer 10 and 11  

SciTech Connect

Recently the authors reported that radio Doppler data generated by NASA`s Deep Space Network (DSN) with the Pioneer 10 and 11 spacecraft indicate an apparent anomalous, constant, spacecraft acceleration with a magnitude {approximately}8.5 {times} 10{sup {minus}8} cm s{sup {minus}2}, directed towards the Sun. Analysis of similar Doppler and ranging data from the Galileo and Ulysses spacecraft yielded ambiguous results for the anomalous acceleration, but the analysis was useful in that it ruled out the possibility of a systematic error in the DSN Doppler system that could easily be mistaken as a spacecraft acceleration. Here they present some new results, including a critique of the suggestion that the anomalous acceleration could be caused by collimated thermal emission. Based on upgraded JPL software for the Pioneer 10 orbit determination, and on a new data interval from January 1987 to July 1998, their best estimate of the average Pioneer 10 acceleration directed towards the Sun is 7.20 {sup {minus}} 0.11 {times} 10{sup {minus}8} cm s{sup {minus}2}.

Anderson, J.D.; Lau, E.L.; Turyshev, S.G. [California Inst. of Tech., Pasadena, CA (United States). Jet Propulsion Lab.; Laing, P.A. [Aerospace Corp., El Segundo, CA (United States); Liu, A.S. [Astrodynamic Sciences, Los Angeles, CA (United States); Nieto, M.M. [Los Alamos National Lab., NM (United States). Theoretical Div.

1999-07-01

333

19 CFR 12.10 - Regulations and orders of the Department of Agriculture.  

Code of Federal Regulations, 2013 CFR

...Regulations and orders of the Department of Agriculture. 12.10 Section 12.10 Customs...Regulations and orders of the Department of Agriculture. The importation into the United...regulations and orders of the Department of Agriculture restricting or prohibiting the...

2013-04-01

334

New ?-aminovinylketonates with annealated 1,2-benzothiazine-1,1-dioxide fragment  

Microsoft Academic Search

New ?-aminovinylketones with heterocyclic 1,2-benzothiazine-1,1-dioxide and antipyrine moieties (LH) and their 3d-metal (CoII, NiII, CuII, ZnII) chelates have been synthesized. Two types of chelates can be obtained based on the coordination of the LH ligand, depending when an available carbonyl (C?O) group of the antipyrine fragment is coordinated (M=Co, Ni) or not (M=Cu) to the metal center. The molecular structure

A. D Garnovskii; Boris I Kharisov; E. L Anpilova; A. V Bicherov; O. Yu Korshunov; A. S Burlov; Miguel A Méndez-Rojas; L. M Blanco; G. S Borodkin; I. E Uflyand; U Ortiz Méndez

2004-01-01

335

Morphological transformation of C3H/10T1/2 CL8 cells by procarcinogens  

SciTech Connect

In order to increase the sensitivity of the C3H/10T1/2 CL8 (10T1/2) cell transformation system, the chemical exposure period was increased to a total of 6 days (two consecutive 3-day exposures). Using this modified procedure, we transformed 10T1/2 cells with procarcinogens such as aflatoxin B/sub 1/, benz(a)anthracene, and 4-nitroquinoline-1-oxide which have been negative in the standard 10T1/2 cell transformation assay. However, ..beta..-naphthylamine was inconclusive and 2-acetylaminofluorine was negative in this modified assay system. Results demonstrate that a simple modification of the 10T1/2 cell transformation method can increase the sensitivity to some procarcinogens that require metabolic activation.

Oshiro, Y.; Balwierz, P.S.

1982-01-01

336

Study of chlorofluorocarbons CFC-11 and CFC-12 in Brazil: 2. Metropolitan area of São Paulo  

NASA Astrophysics Data System (ADS)

This work presents daily and spatial variations of CFC-11 and CFC-12 in the metropolitan area of São Paulo city (23.5°S; 46.6°O). There is a large spatial and temporal variation in the concentration of CFC-12 in this area. The data obtained in monthly campaigns in the metropolitan region showed the existence of emissions of CFC-12, probably originated in the central area of the city. In daily samplings performed in June, July, August, September, November and December, it was observed that the emissions are concentrated in weekdays (Monday to Friday), relating the emissions of this gas with its use in commercial and industrial activities. These results are indicatives that emissions of CFC-12 are still present, being significant in urban areas. Its potential of emission has to be considered in future analyses. Acknowledgments: We would like to INPE and to Laboratório de Ozô;nio for the facilities to do this work and to CNPq, for the financial support.

Marani, L.; Alvalá, P. C.

337

Theory and modeling in nanoscience: Report of the May 10-11, 2002Workshop  

SciTech Connect

On May 10 and 11, 2002, a workshop entitled ''Theory and Modeling in Nanoscience'' was held in San Francisco, California, sponsored by the offices of Basic Energy Science and Advanced Scientific Computing Research of the Department of Energy. The Basic Energy Sciences Advisory Committee and the Advanced Scientific Computing Advisory Committee convened the workshop to identify challenges and opportunities for theory, modeling, and simulation in nanoscience and nanotechnology, and additionally to investigate the growing and promising role of applied mathematics and computer science in meeting those challenges. This report is the result of those contributions and the discussions at the workshop.

McCurdy, C. William; Stechel, Ellen; Cummings, Peter; Hendrickson, Bruce; Keyes, David

2002-06-28

338

Public Hearings: Gambling, Law Enforcement, Organized Crime Held at Boston, Massachusetts on April 9, 10, and 11, 1975.  

National Technical Information Service (NTIS)

The report contains testimony before the National Gambling Commission concerning gambling, law enforcement and organized crime. Hearings were conducted in Boston, Massachusetts on April 9, 10, 11, 1975.

1975-01-01

339

Modeled performance of non-chlorinated substitutes for CFC-11 and CFC-12 in centrifugal chillers  

SciTech Connect

Current scientific evidence indicates that stratospheric chlorine concentrations below two parts-per-billion will be necessary to reverse and prevent ``ozone hole`` formations over the Earth`s polar regions each spring. This makes it unlikely that HCFC alternatives with non-zero ozone depletion potentials (ODPs), no matter how small, will be accepted as refrigerants or blowing agents for foamed insulations for the long term. Pressure to eventually eliminate all high volume uses of chlorine containing refrigerants provides a strong incentive to find HFC or alternative, chlorine-free compounds with P-V-T characteristics similar to R-11 and R-123 for new and existing large centrifugal chiller applications. Stable chlorine-free compounds with normal boiling points near CFC-11 and HCFC-123 are found in the fluorinated propane or butane or fluorinated ether families. These larger molecules have larger vapor phase heat capacities (Cp), molecular weights, and lower critical temperatures which thermodynamically decrease their volumetric capacity and coefficient of performance in simple cycle applications. Larger molar latent heats of vaporization caused by hydrogen bonding in the ethers may improve their net refrigerating effect over CFC-11 and HCFC-123, however. Consideration was given to the effects of acoustic velocity in the refrigerant, rotational mach numbers, the application of superheat to avoid ``wet isentropic compression,`` and liquid subcooling before isenthalpic expansion. The results indicate that there are several chlorine-free compounds that give modeled chiller performance comparable to CFC-11 and HCF-123 and better that CFC-12 and HFC-134a. Blends of these refrigerants may be required to mitigate the flammability of some of the alternatives which show the best performance, and modifications to the current chiller cycle such as liquid subcooling and suction gas superhead may offer unique advantages for more complicated, larger refrigerant molecules.

Sand, J.R.; Fischer, S.K. [Oak Ridge National Lab., TN (United States); Joyner, P.A. [Electric Power Research Inst., Palo Alto, CA (United States)

1991-12-31

340

Asn415 in the ?11-?12 Linker Decreases Proton-dependent Desensitization of ASIC1  

PubMed Central

Neurons of the mammalian nervous system express the proton-sensing ion channel ASIC1. Low concentrations of protons in the normal range of extracellular pH, pH 7.4–7.3, shut the pore by a conformational transition referred as steady-state desensitization. Therefore, the potential of local acidification to open ASIC1 relies on proton affinity for desensitization. This property is important physiologically and also can be exploited to develop strategies to increase or decrease the channel response to protons. In a previous study (Li, T., Yang, Y., and Canessa, C. M. (2010) J. Biol. Chem. 285, 22706–22712), we found that Leu-85 in the ?1-?2 linker of the extracellular domain decreases the apparent proton affinity for steady-state desensitization and retards openings, slowing down the time course of the macroscopic currents. Here, we show that Asn-415 in the ?11-?12 linker works together with the ?1-?2 linker to stabilize a closed conformation that delays transition from the closed to the desensitized state. Substitutions of Asn-415 for Cys, Ser, or Gly render ASIC1 responsive to small increases in proton concentrations near the baseline physiological pH.

Li, Tianbo; Yang, Youshan; Canessa, Cecilia M.

2010-01-01

341

MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons.  

PubMed

In many parts of the nervous system, neuronal somata display orderly spatial arrangements. In the retina, neurons of numerous individual subtypes form regular arrays called mosaics: they are less likely to be near neighbours of the same subtype than would occur by chance, resulting in 'exclusion zones' that separate them. Mosaic arrangements provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. Remarkably, mosaics are independent of each other: although a neuron of one subtype is unlikely to be adjacent to another of the same subtype, there is no restriction on its spatial relationship to neighbouring neurons of other subtypes. This independence has led to the hypothesis that molecular cues expressed by specific subtypes pattern mosaics by mediating homotypic (within-subtype) short-range repulsive interactions. So far, however, no molecules have been identified that show such activity, so this hypothesis remains untested. Here we demonstrate in mouse that two related transmembrane proteins, MEGF10 and MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells. MEGF10 and 11 and their invertebrate relatives Caenorhabditis elegans CED-1 and Drosophila Draper have hitherto been studied primarily as receptors necessary for engulfment of debris following apoptosis or axonal injury. Our results demonstrate that members of this gene family can also serve as subtype-specific ligands that pattern neuronal arrays. PMID:22407321

Kay, Jeremy N; Chu, Monica W; Sanes, Joshua R

2012-03-11

342

Distinct Functions of Regions 1.1 and 1.2 of RNA Polymerase ? Subunits from Escherichia coli and Thermus aquaticus in Transcription Initiation*  

PubMed Central

RNA polymerase (RNAP) from thermophilic Thermus aquaticus is characterized by higher temperature of promoter opening, lower promoter complex stability, and higher promoter escape efficiency than RNAP from mesophilic Escherichia coli. We demonstrate that these differences are in part explained by differences in the structures of the N-terminal regions 1.1 and 1.2 of the E. coli ?70 and T. aquaticus ?A subunits. In particular, region 1.1 and, to a lesser extent, region 1.2 of the E. coli ?70 subunit determine higher promoter complex stability of E. coli RNAP. On the other hand, nonconserved amino acid substitutions in region 1.2, but not region 1.1, contribute to the differences in promoter opening between E. coli and T. aquaticus RNAPs, likely through affecting the ? subunit contacts with DNA nucleotides downstream of the ?10 element. At the same time, substitutions in ? regions 1.1 and 1.2 do not affect promoter escape by E. coli and T. aquaticus RNAPs. Thus, evolutionary substitutions in various regions of the ? subunit modulate different steps of the open promoter complex formation pathway, with regions 1.1 and 1.2 affecting promoter complex stability and region 1.2 involved in DNA melting during initiation.

Miropolskaya, Nataliya; Ignatov, Artem; Bass, Irina; Zhilina, Ekaterina; Pupov, Danil; Kulbachinskiy, Andrey

2012-01-01

343

One-coat enameling of stainless steel. [12Kh 18N10T  

SciTech Connect

The Scientific-Research Institute for Enameling of Chemical Machinery has developed 10-1 one-coat enamel and a method of applying it on equipment of 12Kh 18N10T stainless steel. This article gives the results of laboratory tests of the corrosion resistance of the coating, 10-1 one-coat enamel on 12Kh18N10T steel, in certain corrosive media. The corrosion resistance was determined from the loss in weight of the coating after the action of the corrosive medium on it. Concludes that semiproduction and production tests of 12Kh18N10T stainless-steel equipment with a 10-1 one-coat enamel protective coating have shown positive results.

Bednosheya, V.Ya.; Babich, N.F.; Bobovich, O.V.; Borodai, T.P.; Fedorenko, A.M.; Ivanov, V.A.; Ivanova, V.G.; Oleinik, M.I.

1982-09-01

344

Tool perception suppresses 10-12Hz ? rhythm of EEG over the somatosensory area.  

PubMed

The perception of tools vs. other objects has been shown to activate the premotor (BA6) and somatosensory cortex (BA3), which neurally represent object affordance related to tool manipulability (Proverbio et al., 2011). The earliest tool/non-tool discrimination is represented by increased anterior negativity (210-270ms) in response to tools. In this study, we analyzed ? desynchronization with wavelet analysis based on EEG recordings in response to 300 familiar objects vs. tools in 11 participants. The results showed an early 140-175ms ? desynchronization over centro-parietal sites at approximately 10-12Hz during tool perception. The surface scalp distribution of ? power is compatible with neural generators located in the somatosensory cortex, but no source analysis was performed. These results support the hypothesis that there is a temporal and functional relationship between the rapid and transient ? suppression over the centro/parietal area and the successive increase in time-locked post-synaptic potentials (ERPs) in regions processing tool motor affordance. PMID:22543070

Proverbio, Alice Mado

2012-04-20

345

[Effects of TJN-101 ((+)-(6s,7s,R-biar)-5,6,7,8-tetrahydro-1,2,3,12-tetramethoxy-6,7 -dimethyl-10,11-methylenedioxy-6-dibenzo [a,c] cyclooctenol) on liver regeneration after partial hepatectomy, and on regional hepatic blood flow and fine structure of the liver in normal rats].  

PubMed

Effects of TJN-101, one of the components isolated from Schizandra fruits, on liver regeneration after partial hepatectomy, and on regional hepatic blood flow and fine structure of the liver were investigated in normal rats. TJN-101, which was administered orally at the doses of 10, 30 and 100 mg/kg/day for 4 days after partial hepatectomy, increased the regeneration rate of the liver and improved the serum retention rate of BSP which had been dose-dependently decreased after the operation. Elevation of serum protein to control levels, elevation of serum LCAT activity, decrease in plasma insulin and increase in plasma glucagon were all dose-dependent responses to TJN-101. The mitotic index on the 5th day after the operation was hardly influenced by TJN-101. Regional hepatic blood flow was increased after intraduodenal administration of TJN-101 (30 and 100 mg/kg). Ultrastructural studies of liver tissue using the transmission electron microscope revealed that TJN-101 stimulated an increase in rough and smooth endoplasmic reticulum in the groups receiving 100 and 300 mg/kg/day. These results suggest that TJN-101 accelerates both the proliferation of hepatocytes and the recovery of liver function after partial hepatectomy and increases hepatic blood flow. It is also thought that the liver enlargement caused by repeated administration of TJN-101 is associated with the proliferation of endoplasmic reticulum. PMID:3792962

Takeda, S; Kase, Y; Arai, I; Hasegawa, M; Sekiguchi, Y; Funo, S; Aburada, M; Hosoya, E; Mizoguchi, Y; Morisawa, S

1986-10-01

346

12. PWD Drawing 10,0005(463AE1)(1936), 'Electrical Lighting and Power' Mare ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. PWD Drawing 10,000-5(463A-E-1)(1936), 'Electrical Lighting and Power' - Mare Island Naval Shipyard, Battery Test Office & Storage Facility, California Avenue & E Street, Vallejo, Solano County, CA

347

Genetic Variants on Chromosome 10q11.21 are Associated with Ischemic Stroke in the Northern Chinese Han Population.  

PubMed

Genome-wide association studies have revealed two loci (rs1746048 and rs501120) on chromosome 10q11.21 associated with atherosclerosis. The genetic variants are related to chemokine (C-X-C motif) ligand 12, which has been shown to affect atherosclerosis. This study aims to explore the associations between these loci and risk of ischemic stroke in the northern Chinese Han population. A total of 368 patients with ischemic stroke and 381 healthy controls were included in the study. The single-nucleotide polymorphisms rs501120 and rs1746048 were analyzed by polymerase chain reaction-ligation detection reaction methods. Increased risk of ischemic stroke was associated with rs1746048 in a dominant mode. The CT + TT genotype of rs1746048 was represented at an increased frequency among patients with ischemic stroke. The genotype and allele frequencies of rs501120 were similar between patients with ischemic stroke and controls. However, the rs501120 CT + CC genotype and C allele were associated with an increased risk of ischemic stroke in the male subgroup. These correlations still remained after adjusting for confounding risk factors of stroke. Here, we present a study indicating that genetic variation on chromosome 10q11.21 might contribute to stroke susceptibility. PMID:23666823

Zhu, Ruixia; Liu, Xu; He, Zhiyi

2013-05-12

348

MspI RFLP at CRYB1 locus (17q11. 2 yields 17q12)  

SciTech Connect

The probe pbeta8-2 is a 1.7 kb Msp1 fragment cloned into the AccI site of pUC8. The fragment was derived from the clone Lambda18A (1). MspI (CCGG) identifies two alleles with lengths of 2.0 and 1.7 kb respectively. No constant bands are present. CRYB1 has been assigned to 17q11.2->17q12. The localization of pbeta8-2 to this region has been confirmed by genetic linkage studies which show this probe to be a member of a group showing tight linkage to NF1 and each other. No significant deviation from Hardy-Weinberg equilibrium was found. Proper Mendelian segregation was observed in 125 offspring of backcross matings and 68 offspring of intercross matings.

Barker, D.F.; Fain, P.R.; Wright, E.C.; Nguyen (Univ. of Utah Research Park, Salt Lake City (USA)); Tsui, L.C. (The Hospital for Sick Children, Toronto (Canada))

1989-01-25

349

Autosomal dominant zonular cataract with sutural opacities localized to chromosome 17q11-12  

SciTech Connect

Congenital cataracts constitute a morphologically and genetically heterogeneous group of diseases that are a major cause of childhood blindness. Different loci for hereditary congenital cataracts have been mapped to chromosomes 1, 2, 16, and 17q24. We report linkage of a gene causing a unique form of autosomal dominant zonular cataracts with Y-sutural opacities to chromosome 17q11-12 in a three-generation family exhibiting a maximum lod score of 3.9 at D17S805. Multipoint analysis gave a Mod confidence interval of 17 cM. This interval is bounded by the markers D17S799 and D17S798, a region that would encompass a number of candidate genes including that coding for {Beta}A3/A1-crystallin. 30 refs., 2 figs., 1 tab.

Padma, T.; Ayyagari, R.; Murty, J.S. [and others

1995-10-01

350

Phase composition and properties of deformed steel 12Kh18N10T after prolonged heating  

Microsoft Academic Search

1.Plastic deformation substantially accelerates precipitation of s phase and carbides TiC and (Ti, Ni)6C in steel 12Kh18N10T, the intensifying effect decreasing notably when the rolling temperature is raised from 20 to 1000°.2.Plastic deformation substantially reduces the fracture toughness of steel 12Kh18N10T after prolonged holding at 650°. The fracture toughness decreases least after high-temperature and cold deformation with 15% reduction.3.The effect

M. A. Smirnov; A. M. Tolstov; Yu. P. Bulanov; G. V. Kuznetsova; V. P. Vypryazhkin

1979-01-01

351

12 CFR 1263.10 - Ten percent requirement for certain insured depository institution applicants.  

Code of Federal Regulations, 2012 CFR

12 Banks and Banking 9 2012-01-01 2012-01-01 false Ten percent...subject to the 10 percent requirement of section 4(a)(2)(A) of the Bank Act (12 U.S.C. 1424(a)(2)(A)) and § 1263.6(b) shall be deemed to...

2012-01-01

352

10. INTERIOR OF SOUTH SIDE ENCLOSED SCREEN PORCH SHOWING 1/2 ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

10. INTERIOR OF SOUTH SIDE ENCLOSED SCREEN PORCH SHOWING 1/2 SCREEN DOOR TO EXTERIOR AND DOUBLE FRENCH DOORS TO DINING ROOM. HOLE AT BOTTOM LEFT OF 1/2 SCREEN DOOR WAS A CAT DOOR. VIEW TO EAST. - Big Creek Hydroelectric System, Powerhouse 8, Operator Cottage, Big Creek, Big Creek, Fresno County, CA

353

10 CFR 1706.11 - Organizational conflicts of interest certificate-Advisory or assistance services.  

Code of Federal Regulations, 2013 CFR

...of interest certificate-Advisory or assistance services. 1706.11 Section 1706.11 Energy DEFENSE NUCLEAR FACILITIES SAFETY BOARD ORGANIZATIONAL AND CONSULTANT CONFLICTS OF INTERESTS § 1706.11 Organizational conflicts of...

2013-01-01

354

10 CFR 1016.11 - Cancellation of requests for security facility approval.  

Code of Federal Regulations, 2013 CFR

...false Cancellation of requests for security facility approval. 1016.11 Section 1016.11 Energy DEPARTMENT OF ENERGY (GENERAL...SAFEGUARDING OF RESTRICTED DATA Physical Security § 1016.11 Cancellation of...

2013-01-01

355

Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.  

PubMed

A number of endothelium-derived relaxing factors have been identified including nitric oxide, prostacyclin, and the epoxyeicosatrienoic acids. Previous work showed that in rabbit aortic endothelial cells, arachidonic acid was metabolized by a lipoxygenase to vasodilatory eicosanoids. The identity was determined by the present study. Aortic homogenates were incubated in the presence of [U-14C]arachidonic acid, [U-14C]arachidonic acid plus 15-lipoxygenase (soybean lipoxidase), or [U-14C]15-hydroxyeicosatetraenoic acid (15-HPETE) and analyzed by reverse phase high pressure liquid chromatography (RP-HPLC). Under both experimental conditions, there was a radioactive metabolite that migrated at 17.5-18.5 min on RP-HPLC. When the metabolite was isolated from aortic homogenates, it relaxed precontracted aortas in a concentration-dependent manner. Gas chromatography/mass spectrometry (GC/MS) of the derivatized metabolite indicated the presence of two products; 11,12,15-trihydroxyeicosatrienoic acid (THETA) and 11,14,15-THETA. A variety of chemical modifications of the metabolite supported these structures and confirmed the presence of a carboxyl group, double bonds, and hydroxyl groups. With the combination of 15-lipoxygenase, arachidonic acid, and aortic homogenate, an additional major radioactive peak was observed. This fraction was analyzed by GC/MS. The mass spectrum was consistent with this peak, containing both the 11-hydroxy-14, 15-epoxyeicosatrienoic acid (11-H-14,15-EETA) and 15-H-11,12-EETA. The hydroxyepoxyeicosatrienoic acid (HEETA) fraction also relaxed precontracted rabbit aorta. Microsomes derived from rabbit aortas also synthesized 11,12,15- and 11,14,15-THETAs from 15-HPETE, and pretreatment with the cyctochrome P450 inhibitor, miconazole, blocked the formation of these products. The present studies suggest that arachidonic acid is metabolized by 15-lipoxygenase to 15-HPETE, which undergoes an enzymatic rearrangement to 11-H-14,15-EETA and 15-H-11,12-EETA. Hydrolysis of the epoxy group results in the formation of 11,14,15- and 11,12,15-THETA, which relaxed rabbit aorta. Thus, the 15-series THETAs join prostacyclin, nitric oxide, and epoxyeicosatrienoic acids as new members of the family of endothelium-derived relaxing factors. PMID:9812980

Pfister, S L; Spitzbarth, N; Nithipatikom, K; Edgemond, W S; Falck, J R; Campbell, W B

1998-11-20

356

Hair-cycle dependent differential expression of ADAM 10 and ADAM 12  

PubMed Central

Background ADAM proteases play important roles in processes of development and differentiation. However, no report has been found in the literature addressing the expression and function of ADAM proteases during hair cycling. Results Cytoplasmic expression pattern of ADAM 10, 12 was similar between normal epidermis and hair infundibulum. In addition, cytoplasmic expression of ADAM 10 was observed in the hair bulb keratinocytes and fibroblasts of dermal papilla in anagen I–III hair follicles. In contrast, decreased ADAM 10 expression was observed in the hair matrix keratinocytes as compared to the hair bulb keratinocytes in anagen I–III hair follicles. Interestingly, ADAM 10 immunoreactivity was expressed weakly in the lower portion of outer root sheath (ORS) of anagen VI hair follicles, and strong ADAM 10 expression was detected in the ORS of catagen and telogen hair follicles. By contrast, ADAM 12 expression was not detected in the hair bulb keratinocytes of anagen I–III hair follicles. ADAM 12 immunoreactivity firstly appeared in the inner root sheath ( IRS ) of anagen IV—V hair follicles and was down-regulated in the IRS and hair cortex and medulla of catagen hair follicles, Strong ADAM 12 immunoreactivity was observed in the ORS of catagen and telogen hair follicles. Material and methods Samples of normal human skin (n = 30) were used. Immunohistochemical analysis was performed using ADAM 10, 12 specific polyclonal antibodies and a sensitive streptavidin-peroxidase technique. Conclusion Our study demonstrates a comparable staining pattern of decreased ADAM 10 immunoreactivity in hair matrix keratinocytes and the basal cell layer of normal epidermis and hair infundibulum. Expression of ADAM 10 in dermal papilla cells may imply a role in the induction and development of anagen hair follicles. In addition, expression of ADAM 10 in the ORS and hair bulb assume the involvment of ADAM 10 in the downward migration of anagen hair follicles. Furthermore ADAM 12 expression in the IRS may indicate a role in the differentiation of anagen hair follicles. Downregulation of ADAM 12 upon the onset of catagen hair stage suggests that ADAM 12 may play an important role of ADAM 12 in the apoptosis of hair follicle keratinocytes. In summary our findings suggest that ADAM 10 and 12 may be of importance for the regulation of hair cycling.

Cho, Baik-Kee; Schramme, Anja; Gutwein, Paul; Tilgen, Wolfgang; Reichrath, Jorg

2009-01-01

357

Phthalazin-1(2H)-one-picric acid (1/1)  

PubMed Central

The geometric parameters of the title compound, C8H6N2O·C6H3N3O7, are in the usual ranges. The three nitro groups are almost coplanar with the aromatic picrate ring [dihedral angles 10.2?(2)°, 7.62?(16) and 8.08?(17)°]. The mol­ecular conformation of the picric acid is stabilized by an intra­molecular O—H?O hydrogen bond. The phthalazin-1(2H)-one mol­ecules are connected via N—H?O hydrogen bonds, forming centrosymmetric dimers.

Yathirajan, H. S.; Narayana, B.; Swamy, M. T.; Sarojini, B. K.; Bolte, Michael

2008-01-01

358

41 CFR 302-12.10 - What are the income tax consequences if I use a relocation services company?  

Code of Federal Regulations, 2012 CFR

...consequences if I use a relocation services company? 302-12.10 Section 302-12.10 Public Contracts and Property Management Federal...RELOCATION ALLOWANCES RESIDENCE TRANSACTION ALLOWANCES 12-USE OF A RELOCATION SERVICES COMPANY...

2012-07-01

359

The U11-48K Protein Contacts the 5' Splice Site of U12Type Introns and the U11-59K Protein  

Microsoft Academic Search

Little is currently known about proteins that make contact with the pre-mRNA in the U12-dependent spliceosome and thereby contribute to intron recognition. Using site-specific cross-linking, we detected an interaction between the U11-48K protein and U12-type 5 splice sites (5ss). This interaction did not require branch point recognition and was sensitive to 5ss mutations, suggesting that 48K interacts with the 5ss

Janne J. Turunen; Cindy L. Will; Michael Grote; Reinhard Luhrmann; Mikko J. Frilander

2008-01-01

360

The characterization and properties of castaprenol-11, -12 and -13 from the leaves of Aesculus hippocastanum (horse chestnut)  

PubMed Central

The isolation and purification of a mixture of cis–trans-polyprenols from the leaves of Aesculus hippocastanum (horse chestnut) are described. Results of studies involving mass spectrometry, nuclear magnetic resonance, infrared spectroscopy, micro-hydrogenation and ozonolytic degradation show the mixture to be made up of undecaprenol, dodecaprenol and tridecaprenol with dodecaprenol predominating. Each of the prenols contains three trans internal isoprene residues and a cis `OH-terminal' isoprene residue. They differ from each other only in the number of cis internal isoprene residues. The trivial names castaprenol-11, castaprenol-12 and castaprenol-13 are proposed to describe these compounds. Gas–liquid-chromatographic and reversed-phase partition thin-layer chromatographic evidence suggest the presence in the mixture of small quantities of castaprenol-10 also.

Wellburn, A. R.; Stevenson, J.; Hemming, F. W.; Morton, R. A.

1967-01-01

361

The first enantiospecific synthesis of (+)-10,11-epoxythapsan-10-ol: revision of the absolute stereochemistry of thapsanes  

Microsoft Academic Search

The first enantiospecific synthesis of (+)-cis,anti,cis-1,8,12,12-tetramethyl-4-oxatricyclo[6.4.0.02,6]dodecan-3-ol (+)-1g, an enantiomer of natural thapsane isolated from Thapsia villosa var minor, is accomplished starting from (R)-carvone, which revises the absolute stereochemistry of natural thapsanes.

A Srikrishna; K Anebouselvy

2002-01-01

362

12 CFR 1203.10 - Contents of the application for award.  

Code of Federal Regulations, 2012 CFR

12 Banks and Banking 9 2012-01-01...1203.10 Section 1203.10 Banks and Banking FEDERAL HOUSING...individual); (3) State that the net worth of the applicant does...other applicants, state that the net worth of the applicant and...

2012-01-01

363

Heterogeneous growth patterns in carriers of chromosome 7p12.2 imbalances affecting GRB10.  

PubMed

Chromosomal duplications and deletions in 7p12.2 have been described in patients with growth disturbance phenotypes, that is, Silver-Russell and Beckwith-Wiedemann syndrome (SRS, BWS). The region harbors the imprinted GRB10/Grb10 gene which has been postulated to belong to a major fetal growth pathway. Based on its genomic localization, its physiological function and its imprinting status, GRB10/Grb10 was considered as a candidate for growth disturbance disorders. However, based on case reports with imbalances of the GRB10 locus it has been suggested that the altered GRB10 copy number should be responsible for the aberrant growth phenotype rather than an altered imprinting status of the gene. We now report on a patient with an increased height and weight in his first years of life carrying a de-novo duplication (5.1 Mb) of paternal 7p12.2 material. The increased growth in this patient again contradicts the hypothesis that a gain of GRB10 copies leads to growth restriction. Indeed, it is necessary to compare the regions of imbalances in 7p12 and the affected genes in the different patients as other genes than GRB10 in 7p12 might cause these aberrant growth phenotypes. PMID:22987336

Eggermann, Thomas; Begemann, Matthias; Gogiel, Magdalena; Palomares, María; Vallespín, Elena; Fernández, Luis; Cazorla, Rosario; Spengler, Sabrina; García-Miñaúr, Sixto

2012-09-17

364

Coenzyme Q10 protects Pc12 cells from cisplatin-induced DNA damage and neurotoxicity.  

PubMed

The purpose of this study was to investigate the neuroprotective effect of a water-soluble formulation of coenzyme Q10 (WS-CoQ10) in PC12 cells exposed to cisplatin, a chemotherapeutic agent with a dose-limiting factor due to neurotoxicity. In the cytokinesis-block micronucleus cytome assay (CBMN Cyt), WS-CoQ10 (at concentrations of 0.1, 0.5 and 1.0?gmL(-1)) protected PC12 cells from cisplatin-induced DNA damage (0.1?gmL(-1)), reducing the frequency of micronuclei (MNi) and nuclear buds (NBUDs). WS-CoQ10 did not alter the mRNA expression levels of Tp53 (at a concentration of 1.0?gmL(-1)) and exhibited neuroprotective activity by stimulating cisplatin-inhibited neurite outgrowth in nerve growth factor (NGF)-differentiated PC12 cells (at a concentration of 0.1?gmL(-1)). In conclusion, WS-CoQ10 protected the PC12 cells from cisplatin-induced DNA damage and neurotoxicity. Moreover, the neuroprotective effects of WS-CoQ10 suggest a possible application in chemotherapeutic protocols. PMID:23434506

da Silva Machado, Carla; Mendonça, Leonardo Meneghin; Venancio, Vinicius de Paula; Bianchi, Maria Lourdes Pires; Antunes, Lusânia Maria Greggi

2013-02-19

365

Dynamical decay process of 219, 220Ra* formed in 10, 11B + 209Bi reactions  

NASA Astrophysics Data System (ADS)

The excitation functions for both the evaporation residue and fission have been calculated for 10B + 209Bi and 11B + 209Bi reactions forming compound systems 219, 220Ra* , using the dynamical cluster-decay model (DCM) with effects of deformations and orientations of the nuclei included in it. In addition to this, the excitation functions for complete fusion (CF) are obtained by summing the fission cross-sections, neutron evaporation and charged particle evaporation residue cross-sections produced through the ensuremath ? xn and ensuremath pxn ( x = 2, 3, 4) emission channels for the 219Ra system at various incident centre-of-mass energies. Experimentally the CF cross-sections are suppressed and the observed suppression is attributed to the low binding energy of 10, 11B which breaks up into charged fragments. The reported complete fusion (CF) and incomplete fusion (ICF) excitation functions for the 219Ra system are found to be nicely fitted by the calculations performed in the framework of DCM, without invoking a significant contribution from quasi-fission. Although DCM has been applied for a number of compound nucleus decay studies in the recent past, the same is being used here in reference to ICF and subsequent decay processes along with the CF process. Interestingly the main contribution to complete fusion cross-section comes from the fission cross-section at higher incident energies, which in DCM is found to consist of an asymmetric fission window, shown to arise due to the deformation and orientation effects of formation and decay fragments.

Sawhney, G.; Sharma, M. K.

2012-05-01

366

34 CFR 12.11 - What statutory provisions and Executive Orders apply to transfers of surplus Federal real property?  

Code of Federal Regulations, 2013 CFR

...Executive Orders apply to transfers of surplus Federal real property? 12.11 Section...Education DISPOSAL AND UTILIZATION OF SURPLUS FEDERAL REAL PROPERTY FOR EDUCATIONAL...Executive Orders apply to transfers of surplus Federal real property? The...

2013-07-01

367

Hypothalamic 11,12-epoxyeicosatrienoic acid attenuates fever induced by central interleukin-1beta in the rat.  

PubMed

Inhibitors of cytochrome P-450 augment fever in rats and mice, indicating that the metabolite of the enzyme is candidate of endogenous antipyretic. Cytochrome P-450 of arachidonic acid cascade leads to the formation of regioisomeric 5,6-, 8,9- 11,12- and 14,15-epoxyeicosatrienoic acid (EET). Various isomers of EET were administrated into the preoptic area and anterior hypothalamus (PO/AH) to test their influence on fever induced by interleukin-1beta (IL-1beta) administrated into the PO/AH in conscious rats. The IL-beta-induced fever was attenuated in the 11,12-EET-pretreated rats, although 5,6-, 8,9- and 14,15-EET did not affect the fever. Intra-PO/AH injection of 11,12-EET did not alter normal body temperature. The results suggest that 11,12-EET acts in the hypothalamus as an endogenous antipyretic. PMID:11585587

Nakashima, T; Yoshida, Y; Miyata, S; Kiyohara, T

2001-09-14

368

11,12-EET stimulates the association of BK channel ? and ?(1) subunits in mitochondria to induce pulmonary vasoconstriction.  

PubMed

In the systemic circulation, 11,12-epoxyeicosatrienoic acid (11,12-EET) elicits nitric oxide (NO)- and prostacyclin-independent vascular relaxation, partially through the activation of large conductance Ca(2+)-activated potassium (BK) channels. However, in the lung 11,12-EET contributes to hypoxia-induced pulmonary vasoconstriction. Since pulmonary artery smooth muscle cells also express BK channels, we assessed the consequences of BK?(1) subunit deletion on pulmonary responsiveness to 11,12-EET as well as to acute hypoxia. In buffer-perfused mouse lungs, hypoxia increased pulmonary artery pressure and this was significantly enhanced in the presence of NO synthase (NOS) and cyclooxygenase (COX) inhibitors. Under these conditions the elevation of tissue EET levels using an inhibitor of the soluble epoxide hydrolase (sEH-I), further increased the hypoxic contraction. Direct administration of 11,12-EET also increased pulmonary artery pressure, and both the sEH-I and 11,12-EET effects were prevented by iberiotoxin and absent in BK?(1)(-/-) mice. In pulmonary artery smooth muscle cells treated with NOS and COX inhibitors and loaded with the potentiometric dye, di-8-ANEPPS, 11,12-EET induced depolarization while the BK channel opener NS1619 elicited hyperpolarization indicating there was no effect of the EET on classical plasma membrane BK channels. In pulmonary artery smooth muscle cells a subpopulation of BK channels is localized in mitochondria. In these cells, 11,12-EET elicited an iberiotoxin-sensitive loss of mitochondrial membrane potential (JC-1 fluorescence) leading to plasma membrane depolarization, an effect not observed in BK?(1)(-/-) cells. Mechanistically, stimulation with 11,12-EET time-dependently induced the association of the BK ? and ?(1) subunits. Our data indicate that in the absence of NO and prostacyclin 11,12-EET contributes to pulmonary vasoconstriction by stimulating the association of the ? and ?(1) subunits of mitochondrial BK channels. The 11,12-EET-induced activation of BK channels results in loss of the mitochondrial membrane potential and depolarization of the pulmonary artery smooth muscle cells. PMID:23029390

Loot, Annemarieke E; Moneke, Isabelle; Keserü, Benjamin; Oelze, Matthias; Syzonenko, Tetyana; Daiber, Andreas; Fleming, Ingrid

2012-09-24

369

Five 8,11-Substituted Pentacyclo l5.4.0.02,6.03,10.05,9 undecanes. (Reannouncement with New Availability Information).  

National Technical Information Service (NTIS)

The X-ray crystal structures of 11-bromo-11-nitropenta cyclo(5.4.0.02,6.03, 10.05,9)-undecan-8-one (11-bromo-11-nitro-PCU-8-one), 8,11-dibromo-8,11-dintro-PCU, 8,11-dichloro-8,11-dinitro-PCU, 8,11-dinitro-PCU, and 8,8,11,11-tetranitro-PCU are described. X...

J. L. Flippen-Anderson C. George R. Gilardi W. W. Zajac T. R. Walters

1991-01-01

370

41 CFR 301-11.12 - How does the type of lodging I select affect my reimbursement?  

Code of Federal Regulations, 2011 CFR

...ALLOWABLE TRAVEL EXPENSES 11-PER DIEM EXPENSES General Rules § 301-11.12 How does the type of lodging I select affect...commercially but made available to the public by area residents in their homes. (e) Recreational vehicle (trailer/camper)....

2011-07-01

371

41 CFR 301-11.12 - How does the type of lodging I select affect my reimbursement?  

Code of Federal Regulations, 2012 CFR

...ALLOWABLE TRAVEL EXPENSES 11-PER DIEM EXPENSES General Rules § 301-11.12 How does the type of lodging I select affect...commercially but made available to the public by area residents in their homes. (5) Recreational vehicle (trailer/camper)....

2012-07-01

372

Identification and Characterization of Spontaneous Deletions within the Sp11-Sp12 Prophage Region of Escherichia coli O157:H7 Sakai  

PubMed Central

Prophages make up 12% of the enterohemorrhagic Escherichia coli genome and play prominent roles in the evolution and virulence of this food-borne pathogen. Acquisition and loss of and rearrangements within prophage regions are the primary causes of differences in pulsed-field gel electrophoresis (PFGE) patterns among strains of E. coli O157:H7. Sp11 and Sp12 are two tandemly integrated and putatively defective prophages carried by E. coli O157:H7 strain Sakai. In this study, we identified 3 classes of deletions that occur within the Sp11-Sp12 region, at a frequency of ca. 7.74 × 10?4. One deletion resulted in a precise excision of Sp11, and the other two spanned the junction of Sp11 and Sp12. All deletions resulted in shifts in the XbaI fragment pattern observed by PFGE. We sequenced the inducible prophage pool of Sakai but did not identify any mature phage particles corresponding to either Sp11 or Sp12. Deletions containing pchB and psrC, which are Sp11-carried genes encoding proteins known or suspected to regulate type III secretion, did not affect the secretion levels of the EspA or EspB effector. Alignment of the Sp11-Sp12 DNA sequence with its corresponding regions in other E. coli O157:H7 and O55:H7 strains suggested that homologous recombination rather than integrase-mediated excision is the mechanism behind these deletions. Therefore, this study provides a mechanism behind the previously observed genetic instability of this genomic region of E. coli O157:H7.

Chen, Chun; Lewis, Carrie R.; Goswami, Kakolie; Roberts, Elisabeth L.; DebRoy, Chitrita

2013-01-01

373

Newton's Apple Teachers Guides. Seasons 9-10-11-12: A Collection of Lessons and Activities.  

ERIC Educational Resources Information Center

|Newton's Apple is a PBS family science program that explores basic science through high-energy, hands-on demonstrations. This volume is a collection of the teacher's guides from four seasons of Newton's Apple which were originally broadcast from 1991 through 1994. Each of the four seasons in the volume contains 26 lessons and a combination of…

Twin Cities Public Television, St. Paul, MN.

374

Health Education: Cancer Prevention and Control. Curriculum Guides, Grades 10, 11, and 12.  

ERIC Educational Resources Information Center

|These curriculum guidelines for tenth-, eleventh-, and twelfth-grade students discuss the prevention, early detection and treatment, and control of cancer. The nature of cancer, the epidemiological factors related to it, the types of treatments available, and rehabilitation of cancer victims are discussed. Finally, the unit discusses personal and…

New York State Education Dept., Albany. Curriculum Development Center.

375

Cross section for the reaction C-12(e,p)B-11; and its relevance to the formation of B-11 in active galaxies  

NASA Astrophysics Data System (ADS)

An experiment has been conducted in order to furnish new data for an estimate of the influence of electron-induced processes in the formation of B-11 from C-12 at astrophysical sites having large densities of high energy electrons. The cross section for the C-12(e, p)B-12 reaction has been measured at incident electron energies of 21, 25, 35, 45, and 55 MeV at the detection angles of 55, 90 and 125 deg. It is concluded that in cosmic sources with a high energy proton flux that is small by comparison with the total electron flux, the electrospallation and photospallation cross sections are not negligible, although the present data give an electroproduction cross section for B-11 that is lower than recent theoretical results by a factor of 2.

Hoffmann, D. H. H.; Richter, A.; Schrieder, G.; Seegebarth, K.

1983-08-01

376

10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.  

Code of Federal Regulations, 2013 CFR

...exempt from being Unclassified Controlled Nuclear Information. 1017.11 Section 1017...AND PROTECTION OF UNCLASSIFIED CONTROLLED NUCLEAR INFORMATION Initially Determining What Information Is Unclassified Controlled Nuclear Information § 1017.11...

2013-01-01

377

10 CFR 851.11 - Development and approval of worker safety and health program.  

Code of Federal Regulations, 2013 CFR

...false Development and approval of worker safety and health program. 851.11 Section...Energy DEPARTMENT OF ENERGY WORKER SAFETY AND HEALTH PROGRAM Program Requirements...11 Development and approval of worker safety and health program. (a)...

2013-01-01

378

10 CFR 11.15 - Application for special nuclear material access authorization.  

Code of Federal Regulations, 2013 CFR

...Application for special nuclear material access authorization. 11.15 Section...FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...Requirements for Special Nuclear Material Access Authorization § 11.15...

2013-01-01

379

The High-Resolution Spectrum of Water Vapor between 11 600 and 12 750 cm-1  

NASA Astrophysics Data System (ADS)

The absorption spectrum of water vapor has been recorded between 11 600 and 12 750 cm-1with a Fourier transform spectrometer (Kitt Peak, Az) at a resolution of 0.012 cm-1and with a path length of 434 m. The line assignment has led to the determination of 506 accurate energy levels of the (310) (211), (112), (013), (230), (131), (032), and (051) vibrational states which belong to the so-called 3? + ? resonance polyad. The rotational energy levels obtained are on the average in agreement with those reported recently by R. Toth (J. Mol. Spectrosc.166,176-183 (1994)) for the strong bands, but there are differences for highJlevels or weak bands levels (about 15% of all levels). The experimental rotational energy levels have been fitted using Padé-Borel approximants and a set of 104 vibrational energies and rotational, resonance, and centrifugal distortion constants for the (310), (211), (112), (013), (230), (131), (032), and (051) vibrational states have been determined.

Flaud, J.-M.; Camy-Peyret, C.; Bykov, A.; Naumenko, O.; Petrova, T.; Scherbakov, A.; Sinitsa, L.

1997-06-01

380

Double elimination protocol for synthesis of 5,6,11,12-tetradehydrodibenzo[a,e]cyclooctene.  

PubMed

A new method for constructing 5,6,11,12-tetradehydrodibenzo[a,e]cyclooctene is described on the basis of one-pot double elimination protocol. The target molecule, which is the smallest cyclophane with alternate arylene-ethynylene linkage, is synthesized in 61 % yield through oxidative dimerization of ortho-(phenylsulfonylmethyl)benzaldehyde. The initial carbon-carbon bond formation between sp(3) carbons followed by stepwise conversion to sp(2) and finally sp carbons bypasses the difficulty encountered in direct coupling of the sp carbon in the terminal acetylene. The mechanism of this process is discussed. The Wittig-Horner-type coupling is a key reaction employed for the carbon-carbon bond formation. Generation of (E)-vinylsulfone moiety in the first coupling between alpha-sulfonyl anion and aldehyde functions is crucial for the effective second coupling to complete the cyclization. The syn-elimination of the (E)-vinylsulfone moieties in the cyclized intermediate furnishes the acetylenic bonds. PMID:11981884

Orita, Akihiro; Hasegawa, Daiki; Nakano, Takehiko; Otera, Junzo

2002-05-01

381

Eyewitness identification accuracy and response latency: the unruly 10-12-second rule.  

PubMed

Data are reported from 3,213 research eyewitnesses confirming that accurate eyewitness identifications from lineups are made faster than are inaccurate identifications. However, consistent with predictions from the recognition and search literatures, the authors did not find support for the "10-12-s rule" in which lineup identifications faster than 10-12 s maximally discriminate between accurate and inaccurate identifications (D. Dunning & S. Perretta, 2002). Instead, the time frame that proved most discriminating was highly variable across experiments, ranging from 5 s to 29 s, and the maximally discriminating time was often unimpressive in its ability to sort accurate from inaccurate identifications. The authors suggest several factors that are likely to moderate the 10-12-s rule. PMID:15462616

Weber, Nathan; Brewer, Neil; Wells, Gary L; Semmler, Carolyn; Keast, Amber

2004-09-01

382

Investigation of mechanical properties of 03Kh12N10MT steel at low temperatures  

Microsoft Academic Search

Conclusions 1.03Kh12N10MT steel shows high impact strength and work of fracture and a low notch sensitivity to -253°C.2.Cold hardening by rolling represents a reserve strengthening of this steel. In the cold-rolled condition the steel retains its high plasticity, and broken specimens show a tough fracture.3.In the longitudinal as well as in the transverse directions the specimens cut from 12-mm-thick strip

E. S. Kagan; V. I. Kozlovskaya; G. N. Grikurov; Ya. V. Trantsevich

1975-01-01

383

12 CFR 1026.11 - Treatment of credit balances; account termination.  

Code of Federal Regulations, 2010 CFR

...2013-01-01 2013-01-01 false Treatment of credit balances; account termination. 1026.11...TRUTH IN LENDING (REGULATION Z) Open-End Credit § 1026.11 Treatment of credit balances; account termination. (a)...

2013-01-01

384

Li10SnP2S12: An Affordable Lithium Superionic Conductor.  

PubMed

The reaction of Li2S and P2S5 with Li4[SnS4], a recently discovered, good Li(+) ion conductor, yields Li10SnP2S12, the thiostannate analogue of the record holder Li10GeP2S12 and the second compound of this class of superionic conductors with very high values of 7 mS/cm for the grain conductivity and 4 mS/cm for the total conductivity at 27 °C. The replacement of Ge by Sn should reduce the raw material cost by a factor of ?3. PMID:24079534

Bron, Philipp; Johansson, Sebastian; Zick, Klaus; Schmedt Auf der Günne, Jörn; Dehnen, Stefanie; Roling, Bernhard

2013-10-09

385

Isolation of endopeptidase-24.11 (EC 3.4.24.11, "enkephalinase") from the pig stomach. Hydrolysis of substance P, gastrin-releasing peptide 10, [Leu5] enkephalin, and [Met5] enkephalin.  

PubMed

The purpose of this investigation was to isolate the cell-surface enzyme endopeptidase-24.11 from the stomach wall of the pig and to examine the hydrolysis of the gastric neuropeptides. Endopeptidase-24.11 was isolated from gastric membranes by immunoadsorbent chromatography using a monoclonal antibody to porcine kidney endopeptidase-24.11. The enzyme was purified with a yield of 1.2 micrograms/g wet wt of fundic muscle. A single polypeptide chain of apparent subunit molecular weight of 90,000 was identified by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Gastric endopeptidase-24.11 hydrolyzed substance P, gastrin-releasing peptide 10, [Leu5] enkephalin, and [Met5] enkephalin by cleavage of peptide bonds on the N-terminal side of hydrophobic amino acids. The enzymatic activity was inhibited completely by phosphoramidon (10(-6) M) and strongly by 1,10-phenanthroline (10(-3) M), but was unaffected by captopril (10(-5) M). PMID:2457534

Bunnett, N W; Turner, A J; Hryszko, J; Kobayashi, R; Walsh, J H

1988-10-01

386

Composite BPS configurations of p-branes in 10 and 11 dimensions  

NASA Astrophysics Data System (ADS)

We give an overview of various composite BPS configurations of string theory and M-theory p-branes represented as classical supergravity solutions. Type II string backgrounds can be obtained by S- and T-dualities from the NS - NS configurations corresponding to exact conformal sigma-models. The single-centre solutions can also be generated from the Schwarzschild solution by applying a sequence of boosts, `smearings' in some number of dimensions, dualities and taking the extremal limit. The basic `marginal' backgrounds representing threshold BPS bound states of branes are parametrized by a number of independent harmonic functions, one for each brane. `Non-marginal' BPS configurations in D = 10 can be constructed from the marginal ones using U-duality and thus are parametrized, in addition to harmonic functions, by a finite number of O(d,d) and SL(2,R) `angles'. Some of them can be viewed as dimensional reductions of coordinate-transformed (boosted or rotated) marginal configurations of M-branes. We present a new more general class of configurations in which some of the branes or their intersection spaces are localized on other branes. In particular, we find the supergravity background describing the type II BPS configuration of a 3-brane, RR 5-brane and NS - NS 5-brane, and a related `localized' 2-5-5 D = 11 solution. We also consider the classical action for a 3-brane probe moving in such type IIB backgrounds and determine the structure of the corresponding moduli space metrics.

Tseytlin, A. A.

1997-08-01

387

Convenient synthesis of 5,6,11,12,17,18- hexahydrocyclononal[1,2-b:4,5-b':7,8-b'']triindole, a novel phytoestrogen.  

PubMed

An efficient one-pot synthesis is described of 5,6,11,12,17,18-hexahydrocyclononal[1,2-b:4,5-b':7,8-b'']triindole (CTr), a potent estrogen agonist from food plants. For the procedure, gramine is treated with dimethyl sulfate and sodium in ethanol at room temperature. Quenching of the reaction with water and workup of the product provides CTr in approximately 75% yield. PMID:12515475

Staub, Richard E; Bjeldanes, Leonard F

2003-01-10

388

High Resolution Infrared Study of the nu(14), nu(17) and nu(18) bands of (B2H6)-B-11 and (BBH6)-B-10-B-11  

SciTech Connect

Using high resolution Fourier transform spectra, a thorough analysis of the nu14 c-type, nu17 a-type and nu18 a-type bands of both 11B2H6 and 10B11BH6 has been carried in the 10.3, 6.2 and 8.5 um spectral regions, respectively. From this analysis is a large set of precise ground state combination differences with J values up to 36 (31) and Ka values extending to 18 (18) was derived for 11B2H6(10B11BH6). These data were fitted using a Watson-type Hamiltonian leading to accurate ground state rotational constants. An rs value for the B--B distance has been determined to be 1.7645(10) A. The determination of upper state levels of each of the bands are strongly perturbed by nearby dark states. To account for these strong localized resonances, it was necessary to introduce the relevant interacting terms in the Hamiltonian matrix. As a result it was possible to calculate the upper state energy levels quite satisfactorily. From these fits, estimates of the band centers and a few of the rotational constants of the resonating dark states were obtained.

Sams, Robert L. (BATTELLE (PACIFIC NW LAB)); Blake, Thomas A. (BATTELLE (PACIFIC NW LAB)); Sharpe, Steven W. (BATTELLE (PACIFIC NW LAB)); Flaud, Jean-Marie (VISITORS); Lafferty, Walter J. (National Institute of Standards and Technology)

1998-10-01

389

Novel material for nonvolatile ovonic unified memory (OUM) Ag11In12Te26Sb51 phase change semiconductor  

NASA Astrophysics Data System (ADS)

In this paper, Ag11In12Te26Sb51 phase change semiconductor films have been prepared by dc sputtering. The crystallization behaviour of amorphous Ag11In12Te26Sb51 thin films was investigated by using differential scanning calorimetry and x-ray diffraction. It was found that the crystallization temperature is about 483K and the melting temperature is 754.8K and the activation energy for crystallization, Ea, is 2.07eV. The crystalline Ag11In12Te26Sb51 films were obtained using initializer. The initialization conditions have a great effect on the sheet resistance of Ag11In12Te26Sb51 films. We found that the effect of the initialization condition on the sheet resistance can be ascribed to the crystallinity of Ag11In12Te26Sb51 films. The sheet resistance of the amorphous (Ramo) film is found to be larger than 1×106Omega and that of the crystalline (Rcry) film lies in the range from about 103 to 104Omega. So we have the ratio Ramo/Rcry=102~103, which is sufficiently large for application in memory devices.

Liu, Bo; Song, Zhi-Tang; Zhang, Ting; Feng, Song-Lin; Gan, Fu-Xi

2004-07-01

390

Effectiveness of Radon Mitigation Measures in 12 Houses 10 Years after Implementation  

Microsoft Academic Search

Results are presented of radon concentrations in 12 houses 10 years after radon mitigation measures were implemented to reduce elevated radon concentrations in the houses. The houses were part of an earlier radon research project in which the home-owners received remediation advice from radon researchers, and a single contractor carried out the reduction measures. Remediation in nine of the houses

J. P. Rydock; A. Næss-Rolstad; J. T. Brunsell

2002-01-01

391

Eyewitness Identification Accuracy and Response Latency: The Unruly 10-12-Second Rule  

ERIC Educational Resources Information Center

|Data are reported from 3,213 research eyewitnesses confirming that accurate eyewitness identifications from lineups are made faster than are inaccurate identifications. However, consistent with predictions from the recognition and search literatures, the authors did not find support for the "10-12-s rule" in which lineup identifications faster…

Weber, Nathan; Brewer, Neil; Wells, Gary L.; Semmler, Carolyn; Keast, Amber

2004-01-01

392

IMPROVED SCORING OF CHEMICAL TRANSFORMATION OF C3H/10T1/2 CELLS  

EPA Science Inventory

This research program was undertaken to improve the scoring of the transformation by chemical carcinogens of C3H/10T1/2 mouse embryo fibroblasts. (1) A probabilistic view of transformed focus formation in these cells induced by methylcholanthrene (MCA) treatment has been formulat...

393

Alcohol and Drug Prevention Curriculum Resource Guide Grades 10-12: Science--Biology.  

ERIC Educational Resources Information Center

This curriculum resource guide on alcohol and drug prevention provides suggested activities for teachers of grades 10 through 12. Three integrated learning activities for science/biology and healthful living are presented. The science/biology goal is understanding the biology of humans. Healthful living goals include analyzing drug and alcohol use…

North Carolina State Dept. of Public Instruction, Raleigh. Alcohol and Drug Defense Program.

394

Alcohol and Drug Prevention Curriculum Resource Guide Grades 10-12: Communication Skills--English IV.  

ERIC Educational Resources Information Center

This curriculum resource guide on alcohol and drug prevention provides suggested activities for teachers of grades 10 through 12. Four integrated learning activities for communication skills/ English IV and healthful living are presented. Communication skills/literature goals include experiencing young adult literature, using effective techniques…

North Carolina State Dept. of Public Instruction, Raleigh. Alcohol and Drug Defense Program.

395

Dog erythrocyte antigens 1.1, 1.2, 3, 4, 7, and Dal blood typing and cross-matching by gel column technique  

PubMed Central

Background Testing for canine blood types other than dog erythrocyte antigen 1.1 (DEA 1.1) is controversial and complicated by reagent availability and methodology. Objectives The objectives of this study were to use available gel column technology to develop an extended blood-typing method using polyclonal reagents for DEA 1.1, 1.2, 3, 4, 7, and Dal and to assess the use of gel columns for cross-matching. Methods Dogs (43–75) were typed for DEA 1.1, 1.2, 3, 4, 7, and Dal. Methods included tube agglutination (Tube) using polyclonal reagents, a commercially available DEA 1.1 gel column test kit (Standard-Gel) using monoclonal reagent, and multiple gel columns (Extended-Gel) using polyclonal reagents. Blood from 10 recipient and 15 donor dogs was typed as described above and cross-matched using the gel column technique. Results Of 43 dogs typed for DEA 1.1, 23, 25, and 20 dogs were positive using Standard-Gel, Extended-Gel, and Tube, respectively. Typing for DEA 1.2 was not achievable with Extended-Gel. For 75 dogs typed for DEA 3, 4, and 7, concordance of Extended-Gel with Tube was 94.7%, 100%, and 84%, respectively. Dal, determined only by Extended-Gel, was positive for all dogs. Post-transfusion major cross-matches were incompatible in 10 of 14 pairings, but none were associated with demonstrable blood type incompatibilities. Conclusions Gel column methodology can be adapted for use with polyclonal reagents for detecting DEA 1.1, 3, 4, 7, and Dal. Agglutination reactions are similar between Extended-Gel and Tube, but are more easily interpreted with Extended-Gel. When using gel columns for cross-matching, incompatible blood cross-matches can be detected following sensitization by transfusion, although in this study incompatibilities associated with any tested DEA or Dal antigens were not found.

Kessler, Rebecca J.; Reese, Jessica; Chang, Denise; Seth, Mayank; Hale, Anne S.; Giger, Urs

2011-01-01

396

ABC transporter Pdr10 regulates the membrane microenvironment of Pdr12 in Saccharomyces cerevisiae.  

PubMed

The eukaryotic plasma membrane exhibits both asymmetric distribution of lipids between the inner and the outer leaflet and lateral segregation of membrane components within the plane of the bilayer. In budding yeast (Saccharomyces cerevisiae), maintenance of leaflet asymmetry requires P-type ATPases, which are proposed to act as inward-directed lipid translocases (Dnf1, Dnf2, and the associated protein Lem3), and ATP-binding cassette (ABC) transporters, which are proposed to act as outward-directed lipid translocases (Pdr5 and Yor1). The S. cerevisiae genome encodes two other Pdr5-related ABC transporters: Pdr10 (67% identity) and Pdr15 (75% identity). We report the first analysis of Pdr10 localization and function. A Pdr10-GFP chimera was located in discrete puncta in the plasma membrane and was found in the detergent-resistant membrane fraction. Compared to control cells, a pdr10 mutant was resistant to sorbate but hypersensitive to the chitin-binding agent Calcofluor White. Calcofluor sensitivity was attributable to a partial defect in endocytosis of the chitin synthase Chs3, while sorbate resistance was attributable to accumulation of a higher than normal level of the sorbate exporter Pdr12. Epistasis analysis indicated that Pdr10 function requires Pdr5, Pdr12, Lem3, and mature sphingolipids. Strikingly, Pdr12 was shifted to the detergent-resistant membrane fraction in pdr10 cells. Pdr10 therefore acts as a negative regulator for incorporation of Pdr12 into detergent-resistant membranes, a novel role for members of the ABC transporter superfamily. PMID:19452121

Rockwell, Nathan C; Wolfger, Hubert; Kuchler, Karl; Thorner, Jeremy

2009-05-19

397

The mevalonate pathway in the bloodstream form of Trypanosoma brucei. Identification of dolichols containing 11 and 12 isoprene residues.  

PubMed

The major surface antigen of the bloodstream form of Trypanosoma brucei, the variant surface glycoprotein, is attached to the plasma membrane via a glycosylphosphatidylinositol anchor. The biosynthesis of the glycosylphosphatidylinositol anchor, as well as the assembly of the asparagine-linked oligosaccharide chains found on the variant surface glycoproteins, involves polyisoprenoid lipids that act as sugar carriers. Preliminary observations (Menon, A.K., Schwarz, R.T., Mayor, and Cross, G.A.M. (1990) J. Biol. Chem. 265, 9033-9042) suggested that the sugar carriers in T. brucei were short-chain polyisoprenoids containing substantially fewer isoprene residues than polyisoprenols in mammalian cells. In this paper we describe metabolic labeling experiments with [3H]mevalonate, as well as chromatographic and mass spectrometric analyses of products of the mevalonate pathway in T. brucei. We report that cells of the bloodstream form of T. brucei contain a limited spectrum of short chain dolichols and dolichol phosphates (11 and 12 isoprene residues). The total dolichol content was estimated to be 0.28 nmol/10(9) cells; the dolichyl phosphate content was 0.07 nmol/10(9) cells. The same spectrum of dolichol chain lengths was also found in a polar lipid that could be labeled with [3H]mevalonate, [3H]glucosamine, and [3H]mannose, and which was characterized as Man5GlcNAc2-PP-dolichol. The most abundant product of the mevalonate pathway identified in T. brucei was cholesterol (140 nmol/10(9) cells). Ubiquinone (0.09 nmol/10(9) cells) with a solanesol side chain was also identified. PMID:1918042

Löw, P; Dallner, G; Mayor, S; Cohen, S; Chait, B T; Menon, A K

1991-10-15

398

Pallister-Killian syndrome: tetrasomy of 12pter-->12p11.22 in a boy with an analphoid, inverted duplicated marker chromosome.  

PubMed

Supernumerary marker chromosomes (SMCs) without detectable alphoid DNA are predicted to have a neocentromere and have been referred to as mitotically stable neocentromere marker chromosomes (NMCs). Here we report the molecular cytogenetic characterization of a new case of Pallister-Killian syndrome (PKS) in a boy with an analphoid, inverted duplicated NMC derived from 12pter-->12p11.22 in his fibroblasts by using high-resolution comparative genetic hybridization (HR-CGH), multiplex fluorescent in situ hybridization (FISH) and bacterial artificial chromosome (BAC)-FISH mapping analyses with various alpha-satellite DNA probes, subtelomere probes and BAC-DNA probes. Precise identification of SMCs and NMCs is of essential importance in genetic counseling. HR-CGH is a more informative and often a faster way of precisely identifying the origin of SMCs. This case is the third report of PKS with an NMC containing an inverted duplication of partial 12p with available clinical data. These observations may help to determine the critical region for PKS and the mechanisms leading to the origin of the NMC derived from 12pter-->12p11.22 - a region that appears to be susceptible to the formation of neocentromeres. The use of subtelomeric probe PCP12p in buccal cells appears superior to the use of the centromere probe D12Z3 for the diagnosis of the PKS. PMID:17894838

Huang, X-L; Isabel de Michelena, M; Leon, E; Maher, T A; McClure, R; Milunsky, A

2007-09-25

399

Radial alignment simulation of solar wind streams observed by Pioneers 10 and 11 in 1974  

NASA Astrophysics Data System (ADS)

A particularly favorable radial lineup between spacecraft in Earth orbit and Pioneers 10 and 11 (near the ecliptic plane at approximately 5.5 AU and approximately 4.5 AU, respectively) occurred in mid-1974, when the solar corona was in a stable and well-defined warped-dipole configuration. The radial alignment study reported here differs from previous applications of the technique in two respects: (1) It is the first time a two-dimensional (2-D) MHD model has been tested over such a lengthy propagation interval; the 2-D capability is crucial for treatment of the nonradial shearing motions occurring across the stream interface. (2) The three-dimensional (3-D) structure observed in the white light corona at that time is related to the systematic patterns of nonradial flow deflections appearing at the Pioneer corotating interaction region (CIR) fronts. Comparison of predicted and observed flows for pairs of streams in two successive rotations reveals that when the parent coronal hole projects far across the solar equator in a predominantly north-south orientation (i.e., nearest the 2-D idealization), the mapping is accurate down to details of the flow structures. But where the spacecraft tracks along a latitudinal boundary of a hole or the associated stream front is inclined at a shallow angle to the equator, the numerical projections deviate systematically from the observations. Among the sources of error are 3-D dynamical interactions neglected in the model, differential rotation effects, and slow temporal evolution of the coronal structures. A characteristic pattern of north-south and east-west deflections indicative of the 3-D geometry appears across the CIRs, but these patterns evidently reflect primarily the local, as opposed to global, orientation of the 3-D stream fronts. Such patterns appear common in CIRs observed by Pioneer during this period. These findings thus hold special relevance for the analysis of Ulysses observations, since the present coronal configuration is similar to that of 1974.

Pizzo, V. J.; Intriligator, D. S.; Siscoe, G. L.

1995-07-01

400

Mosaic Intrachromosomal Triplication of (12)(p11.2p13) in a Patient with Pallister-Killian Syndrome.  

PubMed

Pallister-Killian syndrome (PKS) is a rare genetic disorder usually characterized by mosaic tetrasomy of isochromosome 12p detected in cultured fibroblast cells. We describe here a patient with PKS and intrachromosomal triplication of the short arm of chromosome 12. Her karyotype was mos 46,XX,inv trp(12)(p11.2p13)[34]/ 46,XX[16]de novo by conventional cytogenetics and fluorescent in situ hybridization (FISH) analysis. However, this chromosomal abnormality was not detected from the patient's cultured blood lymphocytes. We report here the third patient with intrachromosomal triplication on the short arm of chromosome 12, presenting a PKS phenotype. PMID:24052725

Yakut, S; Mihci, E; Altiok Clark, O; Cetin, Z; Keser, I; Berker, S; Luleci, G

2012-06-01

401

Mosaic Intrachromosomal Triplication of (12)(p11.2p13) in a Patient with Pallister-Killian Syndrome  

PubMed Central

Pallister-Killian syndrome (PKS) is a rare genetic disorder usually characterized by mosaic tetrasomy of isochromosome 12p detected in cultured fibroblast cells. We describe here a patient with PKS and intrachromosomal triplication of the short arm of chromosome 12. Her karyotype was mos 46,XX,inv trp(12)(p11.2p13)[34]/ 46,XX[16]de novo by conventional cytogenetics and fluorescent in situ hybridization (FISH) analysis. However, this chromosomal abnormality was not detected from the patient’s cultured blood lymphocytes. We report here the third patient with intrachromosomal triplication on the short arm of chromosome 12, presenting a PKS phenotype.

Yakut, S; Mihci, E; Altiok Clark, O; Cetin, Z; Keser, I; Berker, S; Luleci, G

2012-01-01

402

Nationwide Surveillance of Influenza during the Pandemic (2009-10) and Post-Pandemic (2010-11) Periods in Taiwan  

PubMed Central

Introduction Although WHO declared the world moving into the post-pandemic period on August 10, 2010, influenza A(H1N1) 2009 virus continued to circulate globally. Its impact was expected to continue during the 2010–11 influenza season. This study describes the nationwide surveillance findings of the pandemic and post-pandemic influenza periods in Taiwan and assesses the impact of influenza A(H1N1) 2009 during the post-pandemic period. Methods The Influenza Laboratory Surveillance Network consisted of 12 contract laboratories for collecting and testing samples with acute respiratory tract infections. Surveillance of emergency room visits and outpatient department visits for influenza-like illness (ILI) were conducted using the Real-Time Outbreak and Disease Surveillance system and the National Health Insurance program data, respectively. Hospitalized cases with severe complications and deaths were reported to the National Notifiable Disease Surveillance System. Results During the 2009–10 influenza season, pandemic A(H1N1) 2009 was the predominant circulating strain and caused 44 deaths. However, the 2010–11 influenza season began with A(H3N2) being the predominant circulating strain, changing to A(H1N1) 2009 in December 2010. Emergency room and outpatient department ILI surveillance displayed similar trends. By March 31, 2011, there were 1,751 cases of influenza with severe complications; 50.1% reported underlying diseases. Of the reported cases, 128 deaths were associated with influenza. Among these, 93 (72.6%) were influenza A(H1N1) 2009 and 30 (23.4%) A(H3N2). Compared to the pandemic period, during the immediate post-pandemic period, increased number of hospitalizations and deaths were observed, and the patients were consistently older. Conclusions Reemergence of influenza A(H1N1) 2009 during the 2010–11 influenza season had an intense activity with age distribution shift. To further mitigate the impact of future influenza epidemics, Taiwan must continue its multifaceted influenza surveillance systems, remain flexible with antiviral use policies, and revise the vaccine policies to include the population most at risk.

Chuang, Jen-Hsiang; Huang, Angela S.; Huang, Wan-Ting; Liu, Ming-Tsan; Chou, Jih-Haw; Chang, Feng-Yee; Chiu, Wen-Ta

2012-01-01

403

Further characterization of the new microdeletion syndrome of 16p11.2-p12.2.  

PubMed

Using aCGH, we have identified a pericentromeric deletion, spanning about 8.2 Mb, within 16p11.2-p12.2 in a patient with developmental delay (DD) and dysmorphic features. This deletion arose de novo and is flanked by segmental duplications. The proposita was the only child of healthy nonconsanguineous parents, born after an uneventful pregnancy, at 40 weeks gestation, by normal delivery. She was referred to us at age 3 10/12 years for evaluation of DD and absent speech. On examination, there were a flat face; low-set, posteriorly rotated ears; high-arched palate; hypotonic face; right single palmar crease; long, thin fingers; and a sacral dimple. Her height was at the 50th centile, weight at the 25th, and OFC at the 30th. Results of DNA FraX, HRB chromosomes, metabolic work-up, audiologic evaluation, brain MRI, electroencephalogram, and heart/abdomen ultrasonography were normal. When last seen, aged 8 years, she had a moderate intellectual disability (ID) and poor speech. She was hyperactive with short attention span and difficulty in concentration, but, based on formal testing, did not have autism. Our patient shows common clinical features to the four individuals described by Ballif et al. [Ballif et al. (2007); Nat Genet 39:1071-1073], and further characterizes the new microdeletion syndrome of 16p11.2-p12.2. aCGH suggests that the deletions of all cases share the same distal breakpoint. Of note, the proximal breakpoint of our proposita overlaps the distal breakpoint of the autistic patients studied by Kumar et al. [Kumar et al. (2008); Hum Mol Genet 17:628-638] and Weiss et al. [Weiss et al. (2008); N Eng J Med 358:667-675], confirming that the 16p region carrying susceptibility to autism is more centromeric. Our observation further defines two different, contiguous 16p genomic regions, responsible for a distinct MCA/ID syndrome, and for autism, respectively. PMID:19449418

Battaglia, Agatino; Novelli, Antonio; Bernardini, Laura; Igliozzi, Roberta; Parrini, Barbara

2009-06-01

404

Effect of Duration of Breastfeeding on Neuropsychological Development at 10 to 12 Years of Age in a Cohort of Healthy Children  

ERIC Educational Resources Information Center

|Aim: The aim of this article was to explore the effect of duration of breastfeeding on neurocognitive development. Method: The long-term effect of breastfeeding on neurodevelopment was examined through a battery of neuropsychological tests in 1403 children (693 females, 710 males; mean age 11y 9mo [SD 6mo], range: 10y 3mo-12y 8mo) who were…

Tozzi, Alberto Eugenio; Bisiacchi, Patrizia; Tarantino, Vincenza; Chiarotti, Flavia; D'elia, Lidia; De Mei, Barbara; Romano, Mariateresa; Gesualdo, Francesco; Salmaso, Stefania

2012-01-01

405

OSM-11 Facilitates LIN12 Notch Signaling during Caenorhabditis elegans Vulval Development  

Microsoft Academic Search

Notch signaling is critical for cell fate decisions during development. Caenorhabditis elegans and vertebrate Notch ligands are more diverse than classical Drosophila Notch ligands, suggesting possible functional complexities. Here, we describe a developmental role in Notch signaling for OSM-11, which has been previously implicated in defecation and osmotic resistance in C. elegans. We find that complete loss of OSM-11 causes

Hidetoshi Komatsu; Michael Y. Chao; Jonah Larkins-Ford; Mark E. Corkins; Gerard A. Somers; Tim Tucey; Heather M. Dionne; Jamie Q. White; Khursheed Wani; Mike Boxem; Anne C. Hart

2008-01-01

406

Congenital arhinia with de novo reciprocal translocation, t(3;12)(q13.2;p11.2).  

PubMed

A female newborn suffering from congenital arhinia with complete airway obstruction is reported. In addition, she had hypertelorism, microphthalmia, high-arched palate, and hypoplasia of the auditory canal and mastoid and facial bones, along with the absence of olfactory bulbs and tracts. She had a de novo reciprocal translocation between chromosomes 3q13.2 and 12p11.2. Certain gene(s) located at either of the breakpoints, 3q13.2 and 12p11.2, may be involved in the pathogenesis of her arhinia. PMID:15372519

Hou, Jia-Woei

2004-10-01

407

Suppression of Annexin A11 in Ovarian Cancer: Implications in Chemoresistance12  

PubMed Central

Ovarian cancer patients treated with cisplatin-based chemotherapy often develop acquired cisplatin resistance and, consequently, cancer recurrence. We have previously reported that annexin A11 is associated with cisplatin resistance and related to tumor recurrence in ovarian cancer patients. In this study, we used small interfering RNA to suppress annexin A11 expression in ovarian cancer cells followed by various in vitro assays. We showed that knockdown of annexin A11 expression reduced cell proliferation and colony formation ability of ovarian cancer cells. Epigenetic silencing of annexin A11 conferred cisplatin resistance to ovarian cancer cells. Through a comprehensive time course study of cisplatin response in ovarian cancer cells with/without suppression of annexin A11 expression using whole-genome oligonucleotide microarrays, we identified a set of differentially expressed genes associated with annexin A11 expression and some patterns of gene expressions in response to cisplatin exposure. These identified genes/patterns were further validated by real-time polymerase chain reaction and immunoblot analysis. Many of them such as HMOX1, TGFBI, LY6D, S100P, EIF4EBP2, DHRS2, and PCSK9 have been involved in apoptosis, cell cycling/proliferation, cell adhesion/migration, transcription regulation, and signal transduction. In addition, immunohistochemistry analyses indicated that annexin A11 immunointensity inversely correlated with HMOX1 immunoreactivity in 142 ovarian cancer patients. In contrast to annexin A11, HMOX1 immunoreactivity positively correlated with in vitro cisplatin resistance in ovarian cancers. Collectively, annexin A11 is directly involved in cell proliferation and cisplatin resistance of ovarian cancer. Manipulation of annexin A11 and its associated genes may represent a novel therapeutic strategy in human ovarian cancers.

Song, Jin; Shih, Ie-Ming; Chan, Daniel W; Zhang, Zhen

2009-01-01

408

Protocadherin-12 Cleavage Is a Regulated Process Mediated by ADAM10 Protein  

PubMed Central

Protocadherins are a group of transmembrane proteins with homophilic binding activity, members of the cadherin superfamily. Apart from their role in adhesion, the cellular functions of protocadherins are essentially unknown. Protocadherin (PCDH)12 was previously identified in invasive trophoblasts and endothelial and mesangial cells in the mouse. Invalidation studies revealed that the protein was required for optimal placental development. In this article, we show that its human homolog is abundantly expressed in various trophoblast subtypes of the human placenta and at lower levels in endothelial cells. We demonstrate that PCDH12 is shed at high rates in vitro. The shedding mechanism depends on ADAM10 and results in reduced cellular adhesion in a cell migration assay. PCDH12 is subsequently cleaved by the ?-secretase complex, and its cytoplasmic domain is rapidly degraded by the proteasome. PCDH12 shedding is regulated by interlinked intracellular pathways, including those involving protein kinase C, PI3K, and cAMP, that either increase or inhibit cleavage. In endothelial cells, VEGF, prostaglandin E2, or histamine regulates PCDH12 shedding. The extracellular domain of PCDH12 was also detected in human serum and urine, thus providing evidence of PCDH12 shedding in vivo. Importantly, we observed an increase in circulating PCDH12 in pregnant women who later developed a pre-eclampsia, a frequent pregnancy syndrome and a major cause of maternal and fetal morbidity and mortality. In conclusion, we speculate that, like in mice, PCDH12 may play an important role in human placental development and that proteolytic cleavage in response to external factors, such as cytokines and pathological settings, regulates its activity.

Bouillot, Stephanie; Tillet, Emmanuelle; Carmona, Guillaume; Prandini, Marie-Helene; Gauchez, Anne-Sophie; Hoffmann, Pascale; Alfaidy, Nadia; Cand, Francine; Huber, Philippe

2011-01-01

409

Characterization of Dibenzo[a,l ]pyrene-trans-11,12-diol (Dibenzo[def,p]chrysene) Glucuronidation by UDP-glucuronosyltransferases  

PubMed Central

Dibenzo[a,l]pyrene (DB[a,l]P) (dibenzo[def,p]chrysene) is a highly carcinogenic polycyclic aromatic hydrocarbon (PAH) that has been identified in tobacco smoke and is found in our environment due to incomplete combustion of organic matter. Its metabolites are known to form stable DNA adducts in bacteria and mammalian cells, and can lead to tumors in animal models. Glucuronidation of major metabolites of DB[a,l]P by the uridine-5’-diphosphate glucuronosyltransferase (UGT) family of enzymes is an important route of detoxification of this pro-carcinogen. The focus of the current study was to characterize the glucuronidation of the pro-carcinogenic enantiomers DB[a,l]P-(+)-trans-11S,12S–diol and DB[a,l]P-(?)-trans-11R,12R–diol. Glucuronidation assays with HEK293 cell lines over-expressing individual human UGT enzymes demonstrated that UGTs 1A1, 1A4, 1A7, 1A8, 1A9, 1A10, and 2B7 glucuronidated one or both DB[a,l]P-trans-11,12-diol enantiomers. Three glucuronide conjugates were observed in activity assays with UGTs 1A1 and 1A10, while two glucuronides were formed by UGTs 1A7, 1A8, and 1A9, and one glucuronide was made by UGT1A4 and UGT2B7. Enzyme kinetic analysis indicated that UGT1A9 was the most efficient UGT at forming both the (+)-DB[a,l]P-11-Gluc and (?)-DB[a,l]P-11-Gluc products while UGTs 1A1 and 1A10 were the most efficient at forming the (+)-DB[a,l]P-12-Gluc product (as determined by the kcat/KM). Incubations with human liver microsomes showed formation of three diastereomeric glucuronide products: (+)-DB[a,l]P-11-Gluc, (+)-DB[a,l]P-12-Gluc, and (?)-DB[a,l]P-11-Gluc, with an average overall ratio of 31 : 32 : 37 in four liver specimens. Human bronchus and trachea tissue homogenates demonstrated glucuronidation activity against both DB[a,l]P-trans-11,12-diol enantiomers, with both tissues producing the (+)-DB[a,l]P-11-Gluc and (+)-DB[a,l]P-12-Gluc with little or no formation of (?)-DB[a,l]P-11-Gluc. These results indicate that multiple UGTs are involved in the stereospecific glucuronidation of DB[a,l]P-trans-11,12-diol in a pattern consistent with their expression in respiratory tract tissues, and that glucuronidation may be an important first-line detoxification mechanism of DB[a,l]P metabolites.

Olson, Kristine C.; Sun, Dongxiao; Chen, Gang; Sharma, Arun K.; Amin, Shantu; Ropson, Ira J.; Spratt, Thomas E.; Lazarus, Philip

2011-01-01

410

Synthesis of 1,2,3,4,8,9,10,11-octasubstituted pentacenequinone derivatives and their conversion into substituted pentacenes.  

PubMed

A series of 1,2,3,4,8,9,10,11-octasubstituted pentacenequinone derivatives were prepared by the oxidation of 1,2,3,4,8,9,10,11-octasubstituted pentacenes, which were synthesized by the double homologation method. Oxidation of the pentacenes was carried out with H(5)IO(6) or air and DDQ. These octasubstituted pentacenequinones were converted into 1,2,3,4,6,8,9,10,11,13-decasubstituted or 2,3,6,9,10,13-hexasubstituted pentacene derivatives by the introduction of aryl or alkynyl groups at the carbonyl carbons. The photophysical properties of these new pentacenes have been measured in solution, and the substituent effects are discussed. PMID:20455241

Li, Shi; Zhou, Lishan; Nakajima, Kiyohiko; Kanno, Ken-ichiro; Takahashi, Tamotsu

2010-07-01

411

Kootenay Lake Fertilization Experiment; Years 11 and 12, Technical Report 2002-2003.  

SciTech Connect

This report examines the results from the eleventh and twelfth years (2002 and 2003) of the Kootenay Lake fertilization experiment. Experimental fertilization has occurred with an adaptive management approach since 1992 in order to restore productivity lost as a result of upstream dams. One of the main objectives of the experiment is to restore kokanee (Oncorhynchus nerka) populations, which are a main food source for Gerrard rainbow trout (Oncorhynchus mykiss). Kootenay Lake is located between the Selkirk and Purcell mountains in southeastern British Columbia. It has an area of 395 km2, a maximum depth of 150 m, a mean depth of 94 m, and a water renewal time of approximately two years. The quantity of agricultural grade liquid fertilizer (10-34-0, ammonium polyphosphate and 28-0-0, urea ammonium nitrate) added to Kootenay Lake in 2002 and 2003 was similar to that added from 1992 to 1996. After four years of decreased fertilizer loading (1997 to 2000), results indicated that kokanee populations had declined, and the decision was made to increase the loads again in 2001. The total load of fertilizer in 2002 was 47.1 tonnes of phosphorus and 206.7 tonnes of nitrogen. The total fertilizer load in 2003 was 47.1 tonnes of phosphorus and 240.8 tonnes of nitrogen. Additional nitrogen was added in 2003 to compensate for nitrogen depletion in the epilimnion. The fertilizer was applied to a 10 km stretch in the North Arm from 3 km south of Lardeau to 3 km south of Schroeder Creek. The maximum surface water temperature in 2002, measured on July 22, was 22 C in the North Arm and 21.3 C in the South Arm. In 2003, the maxima were recorded on August 5 at 20.6 C in the North Arm and on September 2 at 19.7 C in the South Arm. The maximum water temperature in the West Arm was 18.7 C on September 2, 2003. Kootenay Lake had oxygen-saturated water throughout the sampling season with values ranging from about 11-16 mg/L in 2002 and 2003. In both years, Secchi depth followed the expected pattern for an oligo-mesotrophic lake of decreasing in May, June, and early July, concurrent with the spring phytoplankton bloom, and clearing again as the summer progressed. Total phosphorus (TP) ranged from 2-11 {micro}g/L in 2002 and 2-21 {micro}g/L in 2003. With average TP values generally in the range of 3-10 {micro}g/L, Kootenay Lake is considered to be an oligotrophic to oligo-mesotrophic lake. Total dissolved phosphorus (TDP) followed the same seasonal trends as TP in 2002 and 2003 and ranged from 2-7 {micro}g/L in 2002 and from 2-10 {micro}g/L in 2003. Total nitrogen (TN) ranged from 90-380 {micro}g/L in 2002 and 100-210 {micro}g/L in 2003. During both the 2002 and 2003 sampling seasons, TN showed an overall decline in concentration with mid-summer and fall increases at some stations, which is consistent with previous years results. Dissolved inorganic nitrogen (DIN) concentrations showed a more pronounced declining trend over the sampling season compared with TN, corresponding to nitrate (the dominant component of DIN) being used by phytoplankton during summer stratification. DIN ranged from 7-176 {micro}g/L in 2002 and from 8-147 {micro}g/L in 2003. During 2003, discrete depth sampling occurred, and a more detailed look at the nitrate concentrations in the epilimnion was undertaken. There was a seasonal decline in nitrate concentrations, which supports the principle of increasing the nitrogen loading and the nitrogen to phosphorus (N:P) ratio during the fertilizer application period. Chlorophyll a (Chl a) concentrations in Kootenay Lake were in the range of 1.4-5.1 {micro}g/L in 2002 and 0.5-4.9 {micro}g/L in 2003. Over the sampling season, Chl a at North Arm stations generally increased in spring corresponding with the phytoplankton bloom, decreased during the summer, and increased again in the fall with mixing of the water column. The trend was similar, but less pronounced, at South Arm stations in these years, and spring Chl a concentrations were lower. During 2002, total algal biomass averaged during June, July and August was lower in the North

Schindler, E.

2007-02-01

412

10 CFR 1046.11 - Medical and physical fitness qualification standards.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 false Medical and physical fitness qualification standards. ...§ 1046.11 Medical and physical fitness qualification standards. ...meet the applicable medical and physical fitness qualification standards as...

2009-01-01

413

10 CFR 1046.11 - Medical and physical fitness qualification standards.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 false Medical and physical fitness qualification standards. ...§ 1046.11 Medical and physical fitness qualification standards. ...meet the applicable medical and physical fitness qualification standards as...

2010-01-01

414

10 CFR 420.11 - Allocation of funds among the States.  

Code of Federal Regulations, 2010 CFR

... Section 420.11 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM Formula Grant Procedures § 420...Massachusetts 617,000 Michigan 973,000 Minnesota 584,000 Mississippi 279,000...

2010-01-01

415

10 CFR 420.11 - Allocation of funds among the States.  

Code of Federal Regulations, 2013 CFR

... Section 420.11 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION STATE ENERGY PROGRAM Formula Grant Procedures § 420...Massachusetts 617,000 Michigan 973,000 Minnesota 584,000 Mississippi 279,000...

2013-01-01

416

10 CFR 1046.11 - Medical and physical fitness qualification standards.  

Code of Federal Regulations, 2013 CFR

... 2013-01-01 false Medical and physical fitness qualification standards. 1046...DEPARTMENT OF ENERGY (GENERAL PROVISIONS) PHYSICAL PROTECTION OF SECURITY INTERESTS Protective...Personnel § 1046.11 Medical and physical fitness qualification...

2013-01-01

417

10 CFR 1017.11 - Information exempt from being Unclassified Controlled Nuclear Information.  

Code of Federal Regulations, 2010 CFR

...Is Unclassified Controlled Nuclear Information § 1017.11...being Unclassified Controlled Nuclear Information. Information...controlled by the United States Nuclear Regulatory Commission; ...information resulting from research directed toward...

2010-01-01

418

10 CFR 11.15 - Application for special nuclear material access authorization.  

Code of Federal Regulations, 2010 CFR

...Application for special nuclear material access authorization...15 Section 11.15 Energy NUCLEAR REGULATORY COMMISSION...application for special nuclear material access authorization. The combined cost of the OPM...

2009-01-01

419

11 CFR 109.10 - How do political committees and other persons report independent expenditures?  

Code of Federal Regulations, 2013 CFR

...that the Commission receives a new 48- hour report of the subsequent independent...that the Commission receives the report or signed statement by 11...that the Commission receives a new 24-hour report of the subsequent...

2013-01-01

420

10 CFR 11.16 - Cancellation of request for special nuclear material access authorization.  

Code of Federal Regulations, 2013 CFR

...FOR DETERMINING ELIGIBILITY FOR ACCESS TO OR CONTROL OVER SPECIAL NUCLEAR MATERIAL...for Special Nuclear Material Access Authorization § 11.16 ...Determining Eligibility for Access to, or Control Over, Special Nuclear...

2013-01-01

421

Electric-field-gradient tensor and boron site-resolved B11 NMR in single-crystalline YB12  

Microsoft Academic Search

B11 NMR measurements on a single crystal of YB12 have been performed at room temperature at a frequency of 128.4MHz . The electric-field-gradient (EFG) tensor components and the principal axes calculated previously by first-principles methods have been verified experimentally. Three magnetically different boron-atom groups in the B12 cluster were clearly observed for the crystal orientation used in this work. This

Z. Fojud; P. Herzig; O. J. Zogal; A. Pietraszko; A. Dukhnenko; S. Jurga; N. Shitsevalova

2007-01-01

422

Unprecedented Mass Bleaching and Loss of Coral across 12? of Latitude in Western Australia in 2010-11  

PubMed Central

Background Globally, coral bleaching has been responsible for a significant decline in both coral cover and diversity over the past two decades. During the summer of 2010–11, anomalous large-scale ocean warming induced unprecedented levels of coral bleaching accompanied by substantial storminess across more than 12° of latitude and 1200 kilometers of coastline in Western Australia (WA). Methodology/Principal Findings Extreme La-Niña conditions caused extensive warming of waters and drove considerable storminess and cyclonic activity across WA from October 2010 to May 2011. Satellite-derived sea surface temperature measurements recorded anomalies of up to 5°C above long-term averages. Benthic surveys quantified the extent of bleaching at 10 locations across four regions from tropical to temperate waters. Bleaching was recorded in all locations across regions and ranged between 17% (±5.5) in the temperate Perth region, to 95% (±3.5) in the Exmouth Gulf of the tropical Ningaloo region. Coincident with high levels of bleaching, three cyclones passed in close proximity to study locations around the time of peak temperatures. Follow-up surveys revealed spatial heterogeneity in coral cover change with four of ten locations recording significant loss of coral cover. Relative decreases ranged between 22%–83.9% of total coral cover, with the greatest losses in the Exmouth Gulf. Conclusions/Significance The anomalous thermal stress of 2010–11 induced mass bleaching of corals along central and southern WA coral reefs. Significant coral bleaching was observed at multiple locations across the tropical-temperate divide spanning more than 1200 km of coastline. Resultant spatially patchy loss of coral cover under widespread and high levels of bleaching and cyclonic activity, suggests a degree of resilience for WA coral communities. However, the spatial extent of bleaching casts some doubt over hypotheses suggesting that future impacts to coral reefs under forecast warming regimes may in part be mitigated by southern thermal refugia.

Moore, James A. Y.; Bellchambers, Lynda M.; Depczynski, Martial R.; Evans, Richard D.; Evans, Scott N.; Field, Stuart N.; Friedman, Kim J.; Gilmour, James P.; Holmes, Thomas H.; Middlebrook, Rachael; Radford, Ben T.; Ridgway, Tyrone; Shedrawi, George; Taylor, Heather; Thomson, Damian P.; Wilson, Shaun K.

2012-01-01

423

Identification of Novel Candidate Oncogenes in Chromosome Region 17p11.2-p12 in Human Osteosarcoma  

PubMed Central

Osteosarcoma is the most common primary malignancy of bone. The tumours are characterized by high genomic instability, including the occurrence of multiple regions of amplifications and deletions. Chromosome region 17p11.2–p12 is amplified in about 25% of cases. In previous studies, COPS3 and PMP22 have been identified as candidate oncogenes in this region. Considering the complexity and variation of the amplification profiles for this segment, the involvement of additional causative oncogenes is to be expected. The aim of the present investigation is to identify novel candidate oncogenes in 17p11.2–p12. We selected 26 of in total 85 osteosarcoma samples (31%) with amplification events in 17p11.2–p12, using quantitative PCR for 8 marker genes. These were subjected to high-resolution SNP array analysis and subsequent GISTIC analysis to identify the most significantly amplified regions. Two major amplification peaks were found in the 17p11.2–p12 region. Overexpression as a consequence of gene amplification is a major mechanism for oncogene activation in tumours. Therefore, to identify the causative oncogenes, we next determined expression levels of all genes within the two segments using expression array data that could be generated for 20 of the selected samples. We identified 11 genes that were overexpressed through amplification in at least 50% of cases. Nine of these, c17orf39, RICH2, c17orf45, TOP3A, COPS3, SHMT1, PRPSAP2, PMP22, and RASD1, demonstrated a significant association between copy number and expression level. We conclude that these genes, including COPS3 and PMP22, are candidate oncogenes in 17p11.2–p12 of importance in osteosarcoma tumourigenesis.

Both, Joeri; Wu, Thijs; Bras, Johannes; Schaap, Gerard R.; Baas, Frank; Hulsebos, Theo J. M.

2012-01-01

424

Oxygenation of 5,8,11-eicosatrienoic acid by prostaglandin H synthase-2 of ovine placental cotyledons: isolation of 13-hydroxy-5,8,11-eicosatrienoic and 11-hydroxy-5,8,12-eicosatrienoic acids  

Microsoft Academic Search

Prostaglandin H synthase-1 of ram vesicular glands metabolises 5,8,11-eicosatrienoic (Mead) acid to 13R-hydroxy-5,8,11-eicosatrienoic and to 11R-hydroxy-5,8,12-eicosatrienoic in a 5:1 ration. We wanted to determine the metabolism of this fatty acid by prostaglandin H synthase-2. Western blot showed that microsomes of sheep and rabbit placental cotyledons contained prostaglandin H synthase-2, while prostaglandin H synthase-1 could not be detected. Microsomes of sheep

Ernst H. Oliw; Lena Hörnsten; Howard Sprecher

1997-01-01

425

a Liquid Argon or Xenon Detector to Observe a Neutrino Magnetic Moment of munu~10-11muB  

Microsoft Academic Search

We describe the current situation in the search for a finite magnetic moment. Solar neutrino experiments can be interpreted in terms of a neutrino magnetic moment of ~10-10-10-11muB. Other astrophysical constraints are very model-dependent. We then describe a technique to detect a magnetic moment using neutrinos from a reactor or low energy neutrino facility and a cryogenic electron drift detector

David B. Cline; Woopyo Hong

1992-01-01

426

12 CFR 1237.11 - Authority of limited-life regulated entities to obtain credit.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 false Authority of limited-life regulated entities to obtain credit. ...CONSERVATORSHIP AND RECEIVERSHIP Limited-Life Regulated Entities § 1237.11 Authority of limited-life regulated entities to obtain credit....

2013-01-01

427

Land-markings: 12 Journeys through 9/11 Living Memorials [DVD  

Treesearch

Land-markings captures stories and images of how we use the landscape as a way to remember people, places, and events. Ranging ... Keywords: healing landscapes, public space, community forestry, stewardship, collective memory, 9- 11.

428

12 CFR 704.11 - Corporate Credit Union Service Organizations (Corporate CUSOs).  

Code of Federal Regulations, 2010 CFR

...2013-01-01 2013-01-01 false Corporate Credit Union Service Organizations (Corporate CUSOs...Section 704.11 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS CORPORATE CREDIT UNIONS §...

2013-01-01

429

12 CFR 950.11 - Capital stock requirements; unilateral redemption of excess stock.  

Code of Federal Regulations, 2010 CFR

...false Capital stock requirements; unilateral redemption of excess stock. 950...11 Capital stock requirements; unilateral redemption of excess stock. (a...capital stock in the Bank. (b) Unilateral redemption of excess capital...

2010-01-01

430

12 CFR 950.11 - Capital stock requirements; unilateral redemption of excess stock.  

Code of Federal Regulations, 2010 CFR

...false Capital stock requirements; unilateral redemption of excess stock. 950...11 Capital stock requirements; unilateral redemption of excess stock. (a...capital stock in the Bank. (b) Unilateral redemption of excess capital...

2009-01-01

431

12 CFR 715.11 - Sanctions for failure to comply with this part.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Sanctions for failure to comply with this part...AUDITS AND VERIFICATIONS § 715.11 Sanctions for failure to comply with this part. (a) Sanctions. Failure of a supervisory...

2013-01-01

432

Atmospheric ice nucleators active ? -12 °C can be quantified on PM10 filters  

NASA Astrophysics Data System (ADS)

Small number concentrations render it difficult to quantify ice nucleators (IN) in the atmosphere active at warm temperatures. A useful new method for IN measurement based around filter collections is proposed. It makes use of quartz filters used in 24 h PM10 monitoring (720 m3 air sample). Small subsamples (1.8 mm diameter) from the effective filter area and from the clean fringe (blank) are subjected to immersion freezing tests. We applied the method to eight filters from the High Alpine Research Station Jungfraujoch (3580 m above sea level) in the Swiss Alps. All filters carried IN active at -7 °C and below. Number concentrations of IN active at -8, -10, and -12 °C were on average 3.3, 10.7, and 17.2 m-3, respectively. Several-fold larger numbers of IN active at ? -12 °C per unit mass of PM10 were found in air masses influenced by Swiss and southern German atmospheric boundary layer air, compared to a Saharan dust event. In combination with data on PM10 mass, the method may be used to re-construct time series of IN number concentrations.

Conen, F.; Henne, S.; Morris, C. E.; Alewell, C.

2012-02-01

433

Atmospheric ice nucleators active ?-12°C may be quantified on PM10 filters  

NASA Astrophysics Data System (ADS)

Small number concentrations render it difficult to quantify ice nucleators (IN) active at warm temperatures. An improved filter method is proposed. It makes use of quartz filters which had been used in 24 h PM10 monitoring (720 m3 air sample). Small subsamples (1.8 mm diameter) from the effective filter area and from the clean fringe (blank) are subjected to immersion freezing tests. We applied the method to eight filters from the High Alpine Research Station Jungfraujoch (3580 m a.s.l.) in the Swiss Alps. All filters carried IN active at -7 °C and below. Number concentrations of IN active at -8, -10, and -12 °C were on average 3.3, 10.7, and 17.2 m-3, respectively. Severalfold larger numbers of IN active at ?-12 °C per unit mass of PM10 were found in air masses influenced by Swiss and Southern German atmospheric boundary layer air, compared to a Saharan dust event. In combination with data on PM10 mass and atmospheric transport simulations, the method may be used to re-construct time series of IN number concentrations.

Conen, F.; Henne, S.; Morris, C. E.; Alewell, C.

2011-11-01

434

HOX A10 and HOX A11 mutation scan in congenital malformations of the female genital tract.  

PubMed

Homeobox (HOX) genes encode a number of transcription factors, expressed along the developmental axis of the female genital tract during the embryonic period. Because HOX A10 and HOX A11 genes are expressed in the embryonic paramesonephric (Müllerian) ducts, abnormally low expression by mutant HOX A10 and HOX A11 genes might cause genital tract anomalies. This case-control study examined if one or more mutations in the HOX A10 and HOX A11 genes are included in the pathogenesis of the female genital tract anomalies. Blood samples were obtained from 30 women diagnosed with malformations of the genital tract (18 with septate uterus, three with bicornuate uterus, two with didelphys uterus, two with unicornuate uterus and five with aplasia/dysplasia) and 100 normal controls. DNA samples prepared from blood leukocytes were used as templates for polymerase chain reaction amplification of DNA fragments from HOX A10 and HOX A11 genes. The gene fragments were tested for DNA sequence differences using single-strand conformation polymorphism analysis and sequenced when genetic variation was detected. No subject showed a plausible causative mutation in HOX A10 or HOX A11; the sole variant observed (P38R) found in a patient with septate uterus was also present in her clinically normal mother. PMID:20457539

Liatsikos, Spiros A; Grimbizis, Grigoris F; Georgiou, Ioannis; Papadopoulos, Nikolaos; Lazaros, Leandros; Bontis, John N; Tarlatzis, Basil C

2010-03-28

435

Multicenter Randomized Trial of 10-French versus 11.5-French Plastic Stents for Malignant Biliary Obstruction  

PubMed Central

Background. There is little prospective data on whether bigger plastic stents are better for patients with malignant biliary obstruction with jaundice. Goals. Multicenter prospective study to compare technical success, clinical response, stent occlusion, and patient survival in patients with malignant biliary obstruction randomized to 10-French or 11.5-French plastic stent. Study. Patients with malignant biliary obstruction were randomized to 10-French or 11.5-French biliary stents. Patients were prospectively assessed for stent occlusion, stent-related interventions, hospital stay, and change in bilirubin. Main outcome measurements included technical success, clinical response, rates of stent occlusion, and survival. Results. 234 patients (47 hilar and 187 common bile duct strictures) were randomized. Outcomes were similar for the 10-French and 11.5-French groups (technical success 99.1% versus 97.4%, P = 0.37). Overall, median stent survival was 213 days, but there was no statistically significant difference in stent survival between 10-French and 11.5-French stents (149 versus 258 days, P = 0.16). Stent survival was significantly longer when placed for common bile duct versus hilar strictures (231 versus 115 days, P = 0.049). Conclusions. The theoretical advantage of improved bile flow for the 11.5-French stent does not translate into more prolonged patency, better clinical response, and longer patient survival than the 10-French stent.

Wagh, Mihir S.; de Bellis, Mario; Fogel, Evan L.; Frakes, James T.; Johanson, John F.; Qaseem, Tahir; Howell, Douglas A.; Lehman, Glen A.; Sherman, Stuart

2013-01-01

436

Repeated crystallization in undercooled Zr41Ti14Cu12Ni10Be23 liquids  

Microsoft Academic Search

Isothermal crystallization studies are performed on Zr41Ti14Cu12Ni10Be23 melts. Undercooling experiments are carried out repeatedly at 907, 860, and 750 K. The scattering of the time to reach the onset of crystallization is investigated. Results from experiments performed at 907 K show a large scatter of the onset time of crystallization. For the experiments carried out at 860 and 750 K,

Jan Schroers; William L. Johnson; Ralf Busch

2000-01-01

437

Neutrophil-derived epoxide, 9,10-epoxy-12-octadecenoate, induces pulmonary edema  

Microsoft Academic Search

We have observed that neutrophils biosynthesize linoleate epoxide, 9,10-epoxy-12-octadecenoate, and have named it leukotoxin\\u000a because of its cytotoxic effect. In this experiment, the effect of leukotoxin on the lung was investigated. Acute effect of\\u000a leukotoxin: Using Wistar rats, leukotoxin (100µmol\\/kg) was injected intravenously for the leukotoxin group, and linoleate (100µmol\\/kg) for the linoleate group. Physiological saline was injected as the

Hu Jia-ning; Fumio Taki; Satoru Sugiyama; Junpei Asai; Yohei Izawa; Tatsuo Satake; Takayuki Ozawa

1988-01-01

438

Crystalline ?-cyclodextrin hydrate is non-stoichiometric with 10.5–12 waters per cyclodextrin molecule  

Microsoft Academic Search

Solid-state C NMR spectroscopy was used to follow the dehydration of ?-cyclodextrin hydrate from 12 to 10.5 waters per cyclodextrin. The process takes place without loss of crystalline order, or the presence of a phase transition. The water molecules involved can best be described as space-filling guests enclathrated in the cyclodextrin cavity. Hence the hydrate is non-stoichiometric within the limits

John A. Ripmeester

1993-01-01

439

Attention demands influence 10- and 12-month-old infants' perseverative behavior.  

PubMed

The present study examined the role of attentional demand on infants' perseverative behavior in a noncommunicative looking version of an A-not-B task. The research aimed at clarifying age-related improvements in the attention process that presumably underlies the development of cognitive control. In a between-subjects design, forty 10-month-olds and forty 12-month-olds were assigned to either a distractor or a no-distractor condition as a means of testing the role of attentional load. The authors used an eye tracker to record infants' looking behavior while they anticipated the reappearance of the target of interest as well as continuously throughout the task. The data demonstrated that 10-month-olds show more perseverative looking than do 12-month-olds and that increased attentional demand leads to more perseverative looking. Correct anticipation, however, was not affected by age or distraction. The results also failed to show that 12-month-olds are better than 10-month-olds at handling the increased attentional demand introduced in the distractor condition, in that the effect of the distractor was not larger for the younger infants. Our results are in line with the theoretical view of cognitive control as dependent on a limited attentional resource, which can explain perseverative behaviors in different tasks and at different ages. PMID:21910526

Watanabe, Hama; Forssman, Linda; Green, Dorota; Bohlin, Gunilla; von Hofsten, Claes

2011-09-12

440

Validation of the Comprehensive Feeding Practices Questionnaire with parents of 10-to-12-year-olds  

PubMed Central

Background There is a lack of validated instruments for quantifying feeding behavior among parents of older children and adolescents. The Comprehensive Feeding Practices Questionnaire (CFPQ) is a self-report measure to assess multiple parental feeding practices. The CFPQ is originally designed for use with parents of children ranging in age from about 2 to 8 years. It is previously validated with American and French parents of children within this age range. The aim of the present study was to adapt and test the validity of this measure with parents of older children (10-to-12-year-olds) in a Norwegian setting. Methods A sample of 963 parents of 10-to-12-year-olds completed a Norwegian, slightly adapted version of the CFPQ. Scale analyses were performed to test the validity of the instrument in our sample. Results Although a few problematic items and scales were revealed, scale analyses showed that the psychometric properties of the slightly adapted, Norwegian version of the CFPQ were surprisingly similar to those of the original CFPQ. Conclusions Our results indicated that the CFPQ, with some small modifications, is a valid tool for measuring multiple parental feeding practices with parents of 10-to12-year-olds.

2011-01-01

441

Chromosome aberrations involving 10q22: report of three overlapping interstitial deletions and a balanced translocation disrupting C10orf11  

PubMed Central

Interstitial deletions of chromosome band 10q22 are rare. We report on the characterization of three overlapping de novo 10q22 deletions by high-resolution array comparative genomic hybridization in three unrelated patients. Patient 1 had a 7.9?Mb deletion in 10q21.3–q22.2 and suffered from severe feeding problems, facial dysmorphisms and profound mental retardation. Patients 2 and 3 had nearly identical deletions of 3.2 and 3.6?Mb, the proximal breakpoints of which were located at an identical low-copy repeat. Both patients were mentally retarded; patient 3 also suffered from growth retardation and hypotonia. We also report on the results of breakpoint analysis by array painting in a mentally retarded patient with a balanced chromosome translocation 46,XY,t(10;13)(q22;p13)dn. The breakpoint in 10q22 was found to disrupt C10orf11, a brain-expressed gene in the common deleted interval of patients 1–3. This finding suggests that haploinsufficiency of C10orf11 contributes to the cognitive defects in 10q22 deletion patients.

Tzschach, Andreas; Bisgaard, Anne-Marie; Kirchhoff, Maria; Graul-Neumann, Luitgard M; Neitzel, Heidemarie; Page, Stephanie; Ahmed, Alischo; Muller, Ines; Erdogan, Fikret; Ropers, Hans-Hilger; Kalscheuer, Vera M; Ullmann, Reinhard

2010-01-01

442

Family10 and Family11 xylanases differ in their capacity to enhance the bleachability of hardwood and softwood paper pulps  

Microsoft Academic Search

Enzyme-aided bleaching of softwood and hardwood kraft pulps by glycosyl hydrolase family-10 and -11 xylanases and a family-26\\u000a mannanase was investigated. The ability to release reducing sugar from pulp xylan and to enhance bleachability is not a characteristic\\u000a shared by all xylanases. Of the six enzymes tested, two xylanases belonging to family 11 were most effective at increasing\\u000a bleachability and

J. H. Clarke; J. E. Rixon; A. Ciruela; H. J. Gilbert; G. P. Hazlewood

1997-01-01

443

Pediatricians' Intention to Recommend Human Papillomavirus (HPV) Vaccines to 11- to 12YearOld Girls Postlicensing  

Microsoft Academic Search

We surveyed 105 pediatric clinicians following Human papillomavirus (HPV) vaccine licensure to identify factors associated with intention to recommend the vaccine to 11- to 12-year-old girls. Pediatricians who were early adopters of medical technologies had fewer concerns about HPV vaccine safety\\/efficacy, and who anticipated parental vaccine safety\\/efficacy concerns reported higher intention to recommend the vaccine.

Kristen A. Feemster; Sarah E. Winters; Alexander G. Fiks; Sara Kinsman; Jessica A. Kahn

2008-01-01

444

The Development of Years 11 and 12 Alternative Courses in Western Australian Government Schools: An Overview and Case Study.  

ERIC Educational Resources Information Center

|Because more Western Australian students are now completing years 11 and 12 and because many of these students are not interested in the traditional college entrance program, a growing number of schools are offering alternative programs. These programs are extremely diverse across the state and may be either prevocational or general, may contain…

Hill, Peter

445

Glasses of impact origin from Apollo 11, 12, 15, and 16 - Evidence for fractional vaporization and mare\\/highland mixing  

Microsoft Academic Search

Electron microprobe analyses have been performed on glasses of impact origin in Apollo 11 breccias (10059, 10060, 10061), Apollo 12 soil (12070), and Apollo 15 breccias (15318, 15425, 15426, 15427). These glasses were produced by shock melting of regolith, rather than of rock. Simple concepts for better understanding and interpreting the chemical data from impact glasses have been developed. These

J. W. Delano; D. H. Lindsley; R. Rudowski

1982-01-01

446

Atmospheric correction of infrared measurements of sea surface temperature using channels at 3.7, 11 and 12 Mum  

Microsoft Academic Search

Atmospheric effects upon the radiometric determination of surface temperature were studied for channels centered at 3.7, 11 and 12 Mum. The error due to the atmosphere is least for the channel centered at 3.7 Mum, which is a real advantage. The use of a linear combination of two or all three of these channels allows one to eliminate most of

P. Y. Deschamps; T. Phulpin

1980-01-01

447

Coping with the 10th anniversary of 9/11: Muslim Americans' sadness, fear, and anger.  

PubMed

The events of 9/11 marked an increase in prejudice, discrimination, and other forms of unfair treatment toward Muslim Americans. We present a study that examined the emotions of Muslim Americans in the days preceding the ten-year 9/11 anniversary. We measured the antecedents (concerns) and consequences (coping) of sadness, fear, and anger. The 9/11 anniversary precipitated intense concerns with loss and discrimination, and intense feelings of sadness, fear, and anger. We measured three coping responses: rumination, avoidance of public places, and religious coping. Participants engaged in all three coping responses, with seeking solace in one's religion being the most frequent response. Moreover, emotions mediated the relationship between concerns and coping responses. Sadness accounted for the association between concern with loss and rumination. Fear explained the association between concern with discrimination and avoidance. Anger accounted for the association between concern with discrimination and religious coping. PMID:23237357

Rodriguez Mosquera, Patricia M; Khan, Tasmiha; Selya, Arielle

2012-12-14

448

Cleanup Verification Package for the 118-H-6:2, 105-H Reactor Ancillary Support Areas, Below-Grade Structures, and Underlying Soils; the 118-H-6:3, 105-H Reactor Fuel Storage Basin and Underlying Soils; The 118-H-6:3 Fuel Storage Basin Deep Zone Side Slope Soils; the 100-H-9, 100-H-10, and 100-H-13 French Drains; the 100-H-11 and 100-H-12 Expansion Box French Drains; and the 100-H-14 and 100-H-31 Surface Contamination Zones  

SciTech Connect

This cleanup verification package documents completion of removal actions for the 105-H Reactor Ancillary Support Areas, Below-Grade Structures, and Underlying Soils (subsite 118-H-6:2); 105-H Reactor Fuel Storage Basin and Underlying Soils (118-H-6:3); and Fuel Storage Basin Deep Zone Side Slope Soils. This CVP also documents remedial actions for the following seven additional waste sties: French Drain C (100-H-9), French Drain D (100-H-10), Expansion Box French Drain E (100-H-11), Expansion Box French Drain F (100-H-12), French Drain G (100-H-13), Surface Contamination Zone H (100-H-14), and the Polychlorinated Biphenyl Surface Contamination Zone (100-H-31).

M. J. Appel

2006-06-29

449

Cu(II) selective sensor based on 5,7,12,14-tetramethyldibenzo[b,i]-1,4,8,11-tetraazacyclotetradecane in PVC matrix  

Microsoft Academic Search

5,7,12,14-tetramethyldibenzo[b,i]-1,4,8,11-tetraazacyclotetradecane, Me4Bzo2[14]aneN4. (I) was synthesized and used as an electroactive material for the fabrication of membrane electrode in PVC matrix for the determination of Cu2+. The best performance was given by the membranes of macrocycle (I) with composition 5:3:100:150 (I:NaTPB:DBBP:PVC). The sensor worked well over a concentration range 2.5 × 10-5-1.0 × 10-1 M of Cu2+ with a slope of

V. K. Gupta; R. Prasad; A. Kumar

2003-01-01

450

11 CFR 100.12 - Identification (2 U.S.C. 431(13)).  

Code of Federal Regulations, 2013 CFR

...2012-01-01 true Identification (2 U.S.C. 431(13)). 100.12 Section 100...GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) General Definitions § 100.12 Identification (2 U.S.C. 431(13)). Identification...

2013-01-01

451

Systematic analysis of above-barrier fusion of {sup 9,10,11}Be+{sup 209}Bi  

SciTech Connect

Measurements of fusion for {sup 9,10,11}Be allow testing of the relative importance to fusion and breakup of the alpha-cluster structure found in all these Be isotopes, compared with the neutron-halo structure only present for {sup 11}Be. However, disagreements exist among different published experimental data sets for the reactions of {sup 9,10,11}Be with {sup 209}Bi. Accurate measurements of above-barrier cross sections for the products of complete fusion (fission and evaporation residues) in the reaction of {sup 9}Be with {sup 209}Bi and {sup 208}Pb provide the basis for a reanalysis of above-barrier fusion for {sup 10,11}Be+{sup 209}Bi. This includes procedures making full use of the higher precision stable beam data and resolves many of the disagreements. The improved self-consistency of the analysis allows investigation of the experimental average fusion barriers. Although showing some scatter, these suggest a higher barrier for the neutron halo nucleus {sup 11}Be. Comparison of published cross sections for fusion associated with capture of all the charge of the projectile suggest that all these Be isotopes show significant suppression of complete fusion, a surprising result given that the alpha-breakup threshold energies are 1.57 MeV for {sup 9}Be but over 7 MeV for {sup 10,11}Be. Further experimental studies to investigate in more detail the division between complete and incomplete fusion for reactions of {sup 10,11}Be are needed.

Hinde, D. J.; Dasgupta, M. [Department of Nuclear Physics, Research School of Physics and Engineering, Australian National University, Canberra, ACT 0200 (Australia)

2010-06-15

452

Trans-11-18 : 1 is effectively Delta9-desaturated compared with trans-12-18 : 1 in humans.  

PubMed

The aim of this human intervention study was to evaluate the Delta9-desaturation of trans-11-18 : 1 (trans-vaccenic acid; tVA) to cis-9,trans-11-18 : 2 (c9,t11 conjugated linoleic acid; CLA) and of trans-12-18 : 1 (t12) to cis-9,trans-12-18 : 2 after a short-term (7 d) and a long-term (42 d) supplementation period. The conversion rates of both trans-18 : 1 isomers were estimated by lipid analysis of serum and red blood cell membranes (RBCM). Subjects started with a 2-week adaptation period without supplements. During the 42 d intervention period, the diet of the test group was supplemented with 3 g/d of tVA and 3 g/d of t12. The diet of the control group was supplemented with a control oil. Serum tVA and t12 levels in the test group increased by fivefold and ninefold after 7 d, respectively, and by eight- and 12-fold after 42 d, respectively, when compared with the adaptation period (P< or =0.002). The serum c9,t11 CLA levels increased by 1.7- and 2.0-fold after 7 d and 42 d, respectively (P< or =0.001). After 42 d, the test group's RBCM c9,t11 CLA content was elevated by 20 % (P=0.021), whereas in the control group it was decreased by 50 % (P=0.002). The conversion rate of tVA was estimated at 24 % by serum and 19 % by RBCM. No increase in c9,t12-18 : 2 was observed in the serum and RBCM, and thus no conversion of t12 could be determined. In conclusion, the endogenous conversion of dietary tVA to c9,t11 CLA contributes approximately one quarter to the human CLA pool and should be considered when determining the CLA supply. PMID:16571155

Kuhnt, Katrin; Kraft, Jana; Moeckel, Peter; Jahreis, Gerhard

2006-04-01

453

Systematic investigation of the drip-line nuclei 11Li and 14Be and their unbound subsystems 10Li and 13Be  

NASA Astrophysics Data System (ADS)

Fragmentation reactions in a carbon target with beams of 11Li and 14Be at relativistic energies have been studied in a kinematically complete experiment at the ALADIN-LAND setup at GSI. Excited states in 11Li and 14Be were obtained from the data in the inelastic channel. The measured cross sections with the core nucleus in the final state show that in the 14Be case core polarization plays an important role. In the one-neutron knockout channels the measured angular correlations between fragment and neutron are asymmetric, which demonstrates the presence of states with different parities in the 11Li and 14Be ground states. For 10Li a low-lying virtual s-state, a p-state and evidence for a d-state could be extracted from the data, while the 12Be+n system shows resonances with more complicated structure.

Simon, H.; Meister, M.; Aumann, T.; Borge, M. J. G.; Chulkov, L. V.; Datta Pramanik, U.; Elze, Th. W.; Emling, H.; Forssén, C.; Geissel, H.; Hellström, M.; Jonson, B.; Kratz, J. V.; Kulessa, R.; Leifels, Y.; Markenroth, K.; Münzenberg, G.; Nickel, F.; Nilsson, T.; Nyman, G.; Richter, A.; Riisager, K.; Scheidenberger, C.; Schrieder, G.; Tengblad, O.; Zhukov, M. V.

2007-07-01

454

High-fidelity view of the structure and fragmentation of the high-mass, filamentary IRDC G11.11-0.12  

NASA Astrophysics Data System (ADS)

Star formation in molecular clouds is intimately linked to their internal mass distribution. We have developed a novel dust extinction mapping technique to derive high-dynamic-range, arcsecond-scale resolution column density data for infrared dark clouds (IRDCs). The technique uses both the near-infrared colors of stars that shine through IRDCs and the mid-infrared surface-brightness features that the IRDCs cause. Using the new technique, we present an unprecedentedly detailed analysis of the column density structure of a high-mass, filamentary IRDC G11.11-0.12 (G11). We also probe the mass distribution of the cloud using dust emission data gathered with Herschel. These two independent techniques yield a strikingly good agreement, highlighting their complementarity and robustness. Using the data, we show that the linear mass density of G11 (Ml ~= 600 Msun/pc) greatly exceeds the critical value of a self-gravitating, non-turbulent cylinder. We further show that G11 harbors a relatively large amount of high-column density gas compared to nearby molecular clouds. By its mass distribution, G11 is analogous to the Orion A cloud, despite its low star-forming activity. This suggests that the amount of dense gas in molecular clouds is more closely connected to environmental properties or galaxy-scale processes than to the star-forming efficiencies of the clouds themselves. We then examine hierarchical fragmentation in G11 over wide ranges of size-scales and densities. We show that at scales 0.5 pc > l > 8 pc, the fragmentation of G11 is in agreement with that of a self-gravitating cylinder. At scales smaller than 0.5 pc, the results agree better with spherical Jeans' fragmentation. One possible explanation for the change in fragmentation characteristics is the size-scale-dependent collapse time-scale that results from the finite size of real molecular clouds: at scales l < 0.5 pc, fragmentation becomes sufficiently rapid to be unaffected by global instabilities.

Kainulainen, Jouni; Ragan, Sarah; Henning, Thomas; Stutz, Amelia

2013-07-01

455

Sup(10,11) B(p, n) Sup(10,11) C Reaction Between E sub(P) = 13.6 and 14.7 MeV.  

National Technical Information Service (NTIS)

Absolute differential cross sections for the n sub 0 and n sub 1 neutron groups for the reaction sup 10 B(p, n) sup 10 C and the n sub 0 , n sub 1 , n sub 2 , n sub 3 , n sub 4 + n sub 5 , n sub 6 and n sub 7 neutron groups for the reaction sup 11 B(p, n)...

H. R. Schelin W. R. Wylie J. L. Cardoso E. F. Pessoa R. A. Douglas

1984-01-01

456

10 CFR 709.11 - Topics within the scope of a polygraph examination.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Topics within the scope of a polygraph examination...Protection of National Security § 709.11 Topics within the scope of a polygraph examination...CI-scope polygraph examination is limited to topics concerning the covered...

2010-01-01

457

10 CFR 709.11 - Topics within the scope of a polygraph examination.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Topics within the scope of a polygraph examination...Protection of National Security § 709.11 Topics within the scope of a polygraph examination...CI-scope polygraph examination is limited to topics concerning the covered...

2013-01-01

458

10 CFR 709.11 - Topics within the scope of a polygraph examination.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 2009-01-01 false Topics within the scope of a polygraph examination...Protection of National Security § 709.11 Topics within the scope of a polygraph examination...CI-scope polygraph examination is limited to topics concerning the covered...

2009-01-01

459

Introduction to special issue commemorating the 10th anniversary of September 11, 2001.  

PubMed

Dr Boscarino was in the World Trade Center complex on September 11, 2001 when the first plane struck the Twin Towers. His World Trade Center work was supported in part by grants from the National Institute of Mental Health (Grants # R01 MH66403 and R21-MH-086317) and the Pennsylvania Department of Health (Contract #4100042573). PMID:21957720

Boscarino, Joseph A

2011-01-01

460

Introduction to Special Issue Commemorating the 10th Anniversary of September 11, 2001  

PubMed Central

Dr. Boscarino was in the World Trade Center complex on September 11, 2001 when the first plane struck the Twin Towers. His World Trade Center work was supported in part by grants from the National Institute of Mental Health (Grants # R01 MH66403 and R21-MH-086317) and the Pennsylvania Department of Health (Contract #4100042573).

Boscarino, Joseph A.

2011-01-01

461

11 CFR 9405.10 - Fees to be charged-categories of requesters.  

Code of Federal Regulations, 2013 CFR

...Commercial use requesters; educational and non-commercial...representatives of the news media; and all other requesters...11(b)). (b) Educational and non-commercial...the request is from an educational institution) or scientific...Representatives of the news media. The...

2013-01-01

462

Fabrication and Evaluation of GaN Layer Composed of m- and \\{10\\bar{1}1\\} Facet Structure  

NASA Astrophysics Data System (ADS)

We grew a GaN layer on a -6.5°-off-angle n-plane patterned sapphire substrate (PSS) by selective-area growth from a sapphire sidewall. A uniform GaN layer with alternately arranged m- and \\{10\\bar{1}1\\} facets on the surface was obtained on the PSS. Multiple quantum wells (MQWs) on the GaN template showed multicolor emission owing to their different structures. The peak wavelength of the MQWs on the \\{10\\bar{1}1\\} facet of 440 nm was longer than that in the case of 405 nm on the m-facet.

Okada, Narihito; Takami, Masaki; Yamada, Yoichi; Tadatomo, Kazuyuki

2013-01-01

463

In Vivo and In Vitro Escape from Neutralizing Antibodies 2G12, 2F5, and 4E10?  

PubMed Central

Recently, passive immunization of human immunodeficiency virus (HIV)-infected individuals with monoclonal antibodies (MAbs) 2G12, 2F5, and 4E10 provided evidence of the in vivo activity of 2G12 but raised concerns about the function of the two membrane-proximal external region (MPER)-specific MAbs (A. Trkola, H. Kuster, P. Rusert, B. Joos, M. Fischer, C. Leemann, A. Manrique, M. Huber, M. Rehr, A. Oxenius, R. Weber, G. Stiegler, B. Vcelar, H. Katinger, L. Aceto, and H. F. Gunthard, Nat. Med. 11:615-622, 2005). In the light of MPER-targeting vaccines under development, we performed an in-depth analysis of the emergence of mutations conferring resistance to these three MAbs to further elucidate their activity. Clonal analysis of the MPER of plasma virus samples derived during antibody treatment confirmed that no changes in this region had occurred in vivo. Sequence analysis of the 2G12 epitope relevant N-glycosylation sites of viruses derived from 13 patients during the trial supported the phenotypic evaluation, demonstrating that mutations in these sites are associated with resistance. In vitro selection experiments with isolates of four of these individuals corroborated the in vivo finding that virus strains rapidly escape 2G12 pressure. Notably, in vitro resistance mutations differed, in most cases, from those found in vivo. Importantly, in vitro selection with 2F5 and 4E10 demonstrated that resistance to these MAbs can be difficult to achieve and can lead to selection of variants with impaired infectivity. This remarkable vulnerability of the virus to interference within the MPER calls for a further evaluation of the safety and efficacy of MPER-targeting therapeutic and vaccination strategies.

Manrique, Amapola; Rusert, Peter; Joos, Beda; Fischer, Marek; Kuster, Herbert; Leemann, Christine; Niederost, Barbara; Weber, Rainer; Stiegler, Gabriela; Katinger, Hermann; Gunthard, Huldrych F.; Trkola, Alexandra

2007-01-01

464

On Campus with Women, Volume 12, Number 2, Fall 1982. 11th Anniversary Issue.  

ERIC Educational Resources Information Center

|News concerning developments at colleges and universities that affect women is presented, along with an interview with the Executive Director of the Project on the Status and Education of Women, Bernice R. Sandler, regarding the project's major accomplishments and activities over the past 11 years and insights into the changing status of women at…

On Campus with Women, 1982

1982-01-01

465

11 CFR 102.10 - Disbursement by check (2 U.S.C. 432(h)(1)).  

Code of Federal Regulations, 2013 CFR

...2012-01-01 true Disbursement by check (2 U.S.C. 432(h)(1)). 102.10 Section 102...RECORDKEEPING BY POLITICAL COMMITTEES (2 U.S.C. 433) § 102.10 Disbursement by check (2 U.S.C. 432(h)(1)). All disbursements...

2013-01-01

466

[A case of male infertility with a reciprocal translocation t(X;14)(p11.4;p12)].  

PubMed

A chromosomal abnormality was found in about 3.6-7.6% of males presenting with azoospermia or oligospermia. Translocations between X chromosome and autosomes are rarely seen genetic disorders that cause male infertility. We described here a 26-year-old infertile male with t(X;14)(p11.4; p12). He showed a normal phenotype without any familial history of congenital abnormalities. The cytogenetic analysis of the proband revealed an X-autosomal translocation, 46,Y,t(X;14)(p11.4;p12), which was inherited from his mother. The testis biopsies indicated the arrest of spermatogenesis. There were no microdeletions of the azoospermia factor a (AZFa), AZFb and AZFc regions in the Y chromosome shown by PCR with 11 sequence-tagged site (STS) markers. According to the literature, male carriers of an X-autosome translocation are invariably sterile, regardless of the position of the break-point in the X chromosome. To our knowledge, this is the first case report of azoospermia with t(X;14)(p11.4;p12) in Korea. PMID:18094566

Hwang, Sang Hyun; Lee, Sun Min; Seo, Eul Ju; Choi, Kyung Un; Park, Hyun Jun; Park, Nam Cheol; Choi, Jin; Lee, Eun Yup

2007-04-01

467

Microstructure study of CoPt thin film with phase change from A1 --> L11 --> A1 --> L10  

NASA Astrophysics Data System (ADS)

In this study, 50-nm-thick CoPt film was sputtered on MgO(111) substrate at substrate temperature (Ts) from room temperature (RT) to 750 °C. Within the temperature range, the phase evolves in the sequence of A1 (disordered) at RT, L11 (ordered), A1, and L10 (ordered) at 750 °C. L11-ordering occurred in the range of 250 °C <= Ts <= 500 °C induces strong perpendicular magnetic anisotropy. Microstructure results indicate that the CoPt grain size increases gradually from about 10 to 50 nm as Ts increases from RT to 600 °C. Grain size significantly increases to larger than 70 nm as Ts > 600 °C, which is attributed to the occurrence of L10-ordering. Further increase Ts to 750 °C, isotropic L10-(111) textured CoPt forms with a higher Hc of 5.0 kOe. Detailed discussion of relation between magnetic behaviors and microstructure is given.

Sun, An-Cheng; Huang, Chuan-Fa

2013-05-01

468

a Liquid Argon or Xenon Detector to Observe a Neutrino Magnetic Moment of ??~10-11?B  

NASA Astrophysics Data System (ADS)

We describe the current situation in the search for a finite magnetic moment. Solar neutrino experiments can be interpreted in terms of a neutrino magnetic moment of ~10-10-10-11?B. Other astrophysical constraints are very model-dependent. We then describe a technique to detect a magnetic moment using neutrinos from a reactor or low energy neutrino facility and a cryogenic electron drift detector with a mass in the range of 1-5 tons. Background estimates are also given for an experimental search. We estimate that a neutrino magnetic moment down to 4×10-11?B can be searched for with this technique. We consider both argon and xeuon to be suitable detector components.

Cline, David B.; Hong, Woopyo

469

The Minor Spliceosomal Protein U11/U12-31K Is an RNA Chaperone Crucial for U12 Intron Splicing and the Development of Dicot and Monocot Plants  

PubMed Central

U12 intron-specific spliceosomes contain U11 and U12 small nuclear ribonucleoproteins and mediate the removal of U12 introns from precursor-mRNAs. Among the several proteins unique to the U12-type spliceosomes, an Arabidopsis thaliana AtU11/U12-31K protein has been shown to be indispensible for proper U12 intron splicing and for normal growth and development of Arabidopsis plants. Here, we assessed the functional roles of the rice (Oryza sativa) OsU11/U12-31K protein in U12 intron splicing and development of plants. The U11/U12-31K transcripts were abundantly expressed in the shoot apical meristems (SAMs) of Arabidopsis and rice. Ectopic expression of OsU11/U12-31K in AtU11/U12-31K-defecient Arabidopsis mutant complemented the incorrect U12 intron splicing and abnormal development phenotypes of the Arabidopsis mutant plants. Impaired cell division activity in the SAMs and inflorescence stems observed in the AtU11/U12-31K-deficient mutant was completely recovered to normal by the expression of OsU11/U12-31K. Similar to Arabidopsis AtU11/U12-31K, rice OsU11/U12-31K was determined to harbor RNA chaperone activity. Collectively, the present findings provide evidence for the emerging idea that the U11/U12-31K protein is an indispensible RNA chaperone that functions in U12 intron splicing and is necessary for normal development of monocotyledonous plants as well as dicotyledonous plants.

Kwak, Kyung Jin; Jung, Hyun Ju; Lee, Kwang Ho; Kim, Young Soon; Kim, Won Yong; Ahn, Sung Ju; Kang, Hunseung

2012-01-01

470

Stability and Performance of Xanthobacter autotrophicus GJ10 during 1,2-Dichloroethane Biodegradation  

PubMed Central

A nucleic acid-based approach was used to investigate the dynamics of a microbial community dominated by Xanthobacter autotrophicus GJ10 in the degradation of synthetic wastewater containing 1,2-dichloroethane (DCE). This study was performed over a 140-day period in a nonsterile continuous stirred-tank bioreactor (CSTB) subjected to different operational regimens: nutrient-limiting conditions, baseline operation, and the introduction of glucose as a cosubstrate. The microbial community was analyzed by a combination of fluorescence in situ hybridization (FISH) and denaturing gradient gel electrophoresis (DGGE). Under nutrient-limiting conditions, DCE degradation was restricted, but this did not affect the dominance of strain GJ10, determined by FISH to comprise 85% of the active population. During baseline operation, DCE degradation improved significantly to over 99.5% and then remained constant throughout the subsequent experimental period. DGGE profiles revealed a stable, complex community, while FISH indicated that strain GJ10 remained the dominant species. During the addition of glucose as a cosubstrate, DGGE profiles showed a proliferation of other species in the CSTB. The percentage of strain GJ10 dropped to 8% of the active population in just 5 days, although this did not affect the DCE biodegradation performance. The return to baseline conditions was accompanied by the reestablishment of strain GJ10 as the dominant species, suggesting that this system responds robustly to external perturbations, both at the functional biodegradation level and at the individual strain level.

Baptista, Ines I. R.; Peeva, Ludmila G.; Zhou, Ning-Yi; Leak, David J.; Mantalaris, Athanasios; Livingston, Andrew G.

2006-01-01

471

41Ca ultratrace determination with isotopic selectivity > 10(12) by diode-laser-based RIMS.  

PubMed

41Ca ultratrace determination by diode-laser-based resonance ionization mass spectrometry with extremely high isotopic selectivity is presented. Application to environmental dosimetry of nuclear reactor components, to cosmochemical investigations of production cross sections, and biomedical isotope-tracer studies of human calcium kinetics are discussed. Future investigations are possible use in 41Ca-radiodating. Depending on the application, 41Ca isotopic abundances in the range of 10(-9) to 10(-15) relative to the dominant stable isotope 40Ca must be determined. Either double- or triple-resonance optical excitation with narrow-band extended cavity diode lasers and subsequent non-resonant photoionization of calcium in a collimated atomic beam were used. The resulting photoions are detected with a quadrupole mass spectrometer optimized for background reduction and neighboring mass suppression. Applying the full triple-resonance scheme provides a selectivity of approximately 5 x 10(12) in the suppression of neighboring isotopes and > 10(8) for isobars, together with an overall detection efficiency of approximately 5 x 10(-5). Measurements on a variety of sample types are discussed; the accuracy and reproducibility of the resulting 41Ca/40Ca isotope ratios was better than 5%. PMID:11496979

Müller, P; Bushaw, B A; Blaum, K; Diel, S; Geppert, C; Nähler, A; Trautmann, N; Nörtershäuser, W; Wendt, K

2001-07-01

472

Developments at the SLOWRI facility at RIKEN: precision optical spectroscopy of 7,9,10,11 Be + ions  

Microsoft Academic Search

Precision optical spectroscopy of radioactive Be isotopes produced in projectile fragmentation has been performed for the\\u000a first time at the prototype SLOWRI facility of RIKEN RI-Beam Factory. The ground state hyperfine constants of 7Be+ and 11Be+ were determined with relative accuracies of 6 × 10?7 and 3 × 10?8, respectively, by laser-microwave double resonance spectroscopy of laser-cooled ions in a

M. Wada; A. Takamine; T. Sonoda; K. Okada; P. Schury

2011-01-01

473

Formation of y + 10 and y + 11 Ions in the Collision-Induced Dissociation of Peptide Ions  

NASA Astrophysics Data System (ADS)

Tandem mass spectra of peptide ions, acquired in shotgun proteomic studies of selected proteins, tissues, and organisms, commonly include prominent peaks that cannot be assigned to the known fragmentation product ions (y, b, a, neutral losses). In many cases these persist even when creating consensus spectra for inclusion in spectral libraries, where it is important to determine whether these peaks represent new fragmentation paths or arise from impurities. Using spectra from libraries and synthesized peptides, we investigate a class of fragment ions corresponding to yn-1 + 10 and yn-1 + 11, where n is the number of amino acid residues in the peptide. These 10 and 11 Da differences in mass of the y ion were ascribed before to the masses of [+ CO - H2O] and [+ CO - NH3], respectively. The mechanism is suggested to involve dissociation of the N-terminal residue at the CH-CO bond following loss of H2O or NH3. MS3 spectra of these ions show that the location of the additional 10 or 11 Da is at the N-terminal residue. The yn-1 + 10 ion is most often found in peptides with N-terminal proline, asparagine, and histidine, and also with serine and threonine in the adjacent position. The yn-1 + 11 ion is observed predominantly with histidine and asparagine at the N-terminus, but also occurs with asparagine in positions two through four. The intensities of the yn-1 + 10 ions decrease with increasing peptide length. These data for yn-1 + 10 and yn-1 + 11 ion formation may be used to improve peptide identification from tandem mass spectra.

Kilpatrick, Lisa E.; Neta, Pedatsur; Yang, Xiaoyu; Simón-Manso, Yamil; Liang, Yuxue; Stein, Stephen E.

2012-04-01

474

Formation of y + 10 and y + 11 Ions in the Collision-Induced Dissociation of Peptide Ions  

NASA Astrophysics Data System (ADS)

Tandem mass spectra of peptide ions, acquired in shotgun proteomic studies of selected proteins, tissues, and organisms, commonly include prominent peaks that cannot be assigned to the known fragmentation product ions (y, b, a, neutral losses). In many cases these persist even when creating consensus spectra for inclusion in spectral libraries, where it is important to determine whether these peaks represent new fragmentation paths or arise from impurities. Using spectra from libraries and synthesized peptides, we investigate a class of fragment ions corresponding to yn-1 + 10 and yn-1 + 11, where n is the number of amino acid residues in the peptide. These 10 and 11 Da differences in mass of the y ion were ascribed before to the masses of [+ CO - H2O] and [+ CO - NH3], respectively. The mechanism is suggested to involve dissociation of the N-terminal residue at the CH-CO bond following loss of H2O or NH3. MS3 spectra of these ions show that the location of the additional 10 or 11 Da is at the N-terminal residue. The yn-1 + 10 ion is most often found in peptides with N-terminal proline, asparagine, and histidine, and also with serine and threonine in the adjacent position. The yn-1 + 11 ion is observed predominantly with histidine and asparagine at the N-terminus, but also occurs with asparagine in positions two through four. The intensities of the yn-1 + 10 ions decrease with increasing peptide length. These data for yn-1 + 10 and yn-1 + 11 ion formation may be used to improve peptide identification from tandem mass spectra.

Kilpatrick, Lisa E.; Neta, Pedatsur; Yang, Xiaoyu; Simón-Manso, Yamil; Liang, Yuxue; Stein, Stephen E.

2011-12-01

475

Trans-10, cis-12 conjugated linoleic acid induced cell death in human colon cancer cells through reactive oxygen species-mediated ER stress.  

PubMed

Dietary conjugated linoleic acids (CLA) are fatty acid isomers with anticancer activities produced naturally in ruminants or from vegetable oil processing. The anticancer effects of CLA differ upon the cancer origin and the CLA isomers. In this study, we carried out to precise the effects of CLA isomers, c9,t11 and t10,c12 CLA, on mechanisms of cell death induction in colon cancer cells. We first showed that only t10,c12 CLA treatment (25 and 50?M) for 72h triggered apoptosis in colon cancer cells without affecting viability of normal-derived colon epithelial cells. Exposure of colon cancer cells to t10,c12 CLA activated ER stress characterized by induction of eIF2? phoshorylation, splicing of Xbp1 mRNA and CHOP expression. Furthermore, we evidenced that inhibition of CHOP expression and JNK signaling decreased t10,c12 CLA-mediated cancer cell death. Finally, we showed that CHOP induction by t10,c12 CLA was dependent on ROS production and that the anti-oxidant N-acetyl-cysteine reduced CHOP induction-dependent cell death. These results highlight that t10,c12 CLA exerts its cytotoxic effect through ROS generation and a subsequent ER stress-dependent apoptosis in colon cancer cells. PMID:23333652

Pierre, Anne-Sophie; Minville-Walz, Mélaine; Fèvre, Cécile; Hichami, Aziz; Gresti, Joseph; Pichon, Laurent; Bellenger, Sandrine; Bellenger, Jérôme; Ghiringhelli, François; Narce, Michel; Rialland, Mickaël

2013-01-15

476

The Venus atmosphere according to data of Venera 11 and 12 optical measurements  

Microsoft Academic Search

Results of spectral and angle measurements of solar radiation in deep layers of the Venus atmosphere are presented. The integral flux of solar radiation at the surface of the Venera-11 landing site amounted to 78 W\\/sq m. The radiative heat influx in the 0.45-1.55 micron range amounted to 15 W\\/sq m above 48 km and 45 W\\/sq m below 48

Iu. M. Golovin; V. I. Moroz; B. E. Moshkin; N. F. Sanko; A. P. Ekonomov

1982-01-01

477

The VP8* domain of neonatal rotavirus strain G10P[11] binds to type II precursor glycans.  

PubMed

Naturally occurring bovine-human reassortant rotaviruses with a P[11] VP4 genotype exhibit a tropism for neonates. Interaction of the VP8* domain of the spike protein VP4 with sialic acid was thought to be the key mediator for rotavirus infectivity. However, recent studies have indicated a role for nonsialylated glycoconjugates, including histo-blood group antigens (HBGAs), in the infectivity of human rotaviruses. We sought to determine if the bovine rotavirus-derived VP8* of a reassortant neonatal G10P[11] virus interacts with hitherto uncharacterized glycans. In an array screen of >600 glycans, VP8* P[11] showed specific binding to glycans with the Gal?1-4GlcNAc motif, which forms the core structure of type II glycans and is the precursor of H type II HBGA. The specificity of glycan binding was confirmed through hemagglutination assays; GST-VP8* P[11] hemagglutinates type O, A, and B red blood cells as well as pooled umbilical cord blood erythrocytes. Further, G10P[11] infectivity was significantly enhanced by the expression of H type II HBGA in CHO cells. The bovine-origin VP4 was confirmed to be essential for this increased infectivity, using laboratory-derived reassortant viruses generated from sialic acid binding rotavirus SA11-4F and a bovine G10P[11] rotavirus, B223. The binding to a core glycan unit has not been reported for any rotavirus VP4. Core glycan synthesis is constitutive in most cell types, and modification of these glycans is thought to be developmentally regulated. These studies provide the first molecular basis for understanding neonatal rotavirus infections, indicating that glycan modification during neonatal development may mediate the age-restricted infectivity of neonatal viruses. PMID:23616650

Ramani, Sasirekha; Cortes-Penfield, Nicolas W; Hu, Liya; Crawford, Sue E; Czako, Rita; Smith, David F; Kang, Gagandeep; Ramig, Robert F; Le Pendu, Jacques; Prasad, B V Venkataram; Estes, Mary K

2013-04-24

478

Internet Use and Psychological Well-Being among 10-Year-Old and 11-Year-Old Children  

ERIC Educational Resources Information Center

|This paper uses data from the 2009 Kids' Life and Times Survey, involving 3657 children aged 10 or 11 years old in Northern Ireland. The survey indicated high levels of use of Internet applications, including social-networking sites and online games. Using the KIDSCREEN-27 instrument, the data indicate that the use of social-networking sites and…

Devine, Paula; Lloyd, Katrina

2012-01-01

479

Study Of Reaction Mechanisms For {sup 9,10,11}Be+{sup 64}Zn Systems Around The Coulomb Barrier  

SciTech Connect

The reactions {sup 9,10,11}Be+{sup 64}Zn have been studied at energies around the Coulomb barrier in order to better understand the role played by the halo features on the reaction dynamics. Preliminary results on such studies will be reported in this paper.

Scuderi, V.; Amorini, F.; Fisichella, M.; Lattuada, M.; Rizzo, F.; Torresi, D. [INFN- Laboratori Nazionali del Sud and sezione di Catania, Catania (Italy); Dipartimento di Fisica ed Astronomia, Universita di Catania, Catania (Italy); Di Pietro, A.; Figuera, P.; Papa, M.; Pellegriti, M. G.; Santonocito, D.; Scalia, G. [INFN- Laboratori Nazionali del Sud and sezione di Catania, Catania (Italy); Acosta, L.; Martel, I. [Departamento de Fisica Aplicada, Universidad de Huelva, Huelva (Spain); Borge, M. J. G.; Sanchez, E. M. R.; Tengblad, O.; Vidal, A. M. [Insto. de Estructura de la Materia, CSIC, Madrid (Spain); Fraile, L. M.; Jeppesen, H. [CERN, Geneva (Switzerland)

2010-04-26

480

Case 2:06-cv-03877-JFB-MLO Document 1-1 Filed 08/10 ...  

Center for Drug Evaluation (CDER)

Text VersionPage 1. Case 2:06-cv-03877-JFB-MLO Document 1-1 Filed 08/10/2006 Page 1 of 14 Page 2. Case 2:06-cv-03877-JFB-MLO ... More results from www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation