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Sample records for 1984-1990 ten-year results

  1. Results in Assisted Peritoneal Dialysis: A Ten-Year Experience

    PubMed Central

    Querido, Sara; Branco, Patrícia Quadros; Costa, Elisabete; Pereira, Sara; Gaspar, Maria Augusta; Barata, José Diogo

    2015-01-01

    Background/Aims. Peritoneal dialysis is a successful renal replacement therapy (RRT) for old and dependent patients. We evaluated the clinical outcomes of an assisted peritoneal dialysis (aPD) program developed in a Portuguese center. Methods. Retrospective study based on 200 adult incident patients admitted during ten years to a PD program. We included all 17 patients who were under aPD and analysed various parameters, including complications with the technique, hospitalizations, and patient and technique survival. Results. The global peritonitis rate was lower in helped than in nonhelped patients: 0.4 versus 0.59 episodes/patient/year. The global hospitalization rate was higher in helped than in nonhelped patients: 0.67 versus 0.45 episodes/patient/year (p = NS). Technique survival in helped patients versus nonhelped patients was 92.3%, 92.3%, 83.1%, and 72.7% versus 91.9%, 81.7%, and 72.1%, and 68.3%, at 1, 2, 3, and 4 years, respectively (p = NS), and patient survival in helped patients versus nonhelped patients was 93.3%, 93.3%, 93.3%, and 74.7% versus 95.9% 93.7%, 89%, and 82% at 1, 2, 3, and 4 years, respectively (p = NS). Conclusions. aPD offers an opportune, reliable, and effective home care alternative for patients with no other RRT options. PMID:26600950

  2. Results in Assisted Peritoneal Dialysis: A Ten-Year Experience.

    PubMed

    Querido, Sara; Branco, Patrícia Quadros; Costa, Elisabete; Pereira, Sara; Gaspar, Maria Augusta; Barata, José Diogo

    2015-01-01

    Background/Aims. Peritoneal dialysis is a successful renal replacement therapy (RRT) for old and dependent patients. We evaluated the clinical outcomes of an assisted peritoneal dialysis (aPD) program developed in a Portuguese center. Methods. Retrospective study based on 200 adult incident patients admitted during ten years to a PD program. We included all 17 patients who were under aPD and analysed various parameters, including complications with the technique, hospitalizations, and patient and technique survival. Results. The global peritonitis rate was lower in helped than in nonhelped patients: 0.4 versus 0.59 episodes/patient/year. The global hospitalization rate was higher in helped than in nonhelped patients: 0.67 versus 0.45 episodes/patient/year (p = NS). Technique survival in helped patients versus nonhelped patients was 92.3%, 92.3%, 83.1%, and 72.7% versus 91.9%, 81.7%, and 72.1%, and 68.3%, at 1, 2, 3, and 4 years, respectively (p = NS), and patient survival in helped patients versus nonhelped patients was 93.3%, 93.3%, 93.3%, and 74.7% versus 95.9% 93.7%, 89%, and 82% at 1, 2, 3, and 4 years, respectively (p = NS). Conclusions. aPD offers an opportune, reliable, and effective home care alternative for patients with no other RRT options. PMID:26600950

  3. Propellant/material compatibility program and results: Ten-year milestones

    NASA Technical Reports Server (NTRS)

    Moran, C.; Bjorkland, R.

    1982-01-01

    The analyses and results of a test program to establish the effects of long term (10 years or more) contact of materials with earth-storable propellants for the purpose of designing chemical propulsion system components which are used for current as well as future planetary spacecraft are described. The period from the publication of JPL TM 33-779 IN 1976 through the testing accomplished in 1981 is covered. The following propellants are reported herein: hydrazine, monomethylhydrazine and nitrogen tetroxide. Materials included the following: aluminum alloys, corrosion resistant steels and a titanium alloy. The results of the testing of more than 80 specimens are included. Material ratings relative to the ten year milepost were assigned. Some evidence of propellant decomposition was found. Titanium is rated as acceptable for ten year applications. Aluminum and stainless steel alloys are also rated as acceptable with few restrictions.

  4. Ten-year results of quality assurance in radiotherapy chart round

    PubMed Central

    2013-01-01

    Background The Royal Australian and New Zealand College of Radiologists (RANZCR) initiated a unique instrument to audit the quality of patient notes and radiotherapy prescriptions. We present our experience collected over ten years from the use of the RANZCR audit instrument. Methods In this study, the results of data collected prospectively from January 1999 to June 2009 through the audit instrument were assessed. Radiotherapy chart rounds were held weekly in the uro-oncology tumour stream and real time feedback was provided. Electronic medical records were retrospectively assessed in September 2009 to see if any omissions were subsequently corrected. Results In total 2597 patients were audited. One hundred and thirty seven (5%) patients had one hundred and ninety nine omissions in documentation or radiotherapy prescription. In 79% of chart rounds no omissions were found at all, in 12% of chart rounds one omission was found and in 9% of chart rounds two or more omissions were found. Out of 199 omissions, 95% were of record keeping and 2% were omissions in the treatment prescription. Of omissions, 152 (76%) were unfiled investigation results of which 77 (51%) were subsequently corrected. Conclusions Real-time audit with feedback is an effective tool in assessing the standards of radiotherapy documentation in our department, and also probably contributed to the high level of attentiveness. A large proportion of omissions were investigation results, which highlights the need for an improved system of retrieval of investigation results in the radiation oncology department. PMID:23617328

  5. Ten years of photonics education at the college level in Ontario: results and by-products

    NASA Astrophysics Data System (ADS)

    Nantel, Marc

    2010-08-01

    In 2000, there was no way for an Ontario student to obtain a credential in optics, laser or photonics without going through graduate school. This was in, arguably, the world-leading jurisdiction in photonics-enabled telecommunications industry. To alleviate this problem and supply the job market with highly-qualified people in the field of optics and photonics, the Ontario Centres of Excellence - then as Photonics Research Ontario - partnered with Algonquin College (Ottawa) and Niagara College (Welland) to establish over the past decade a suite of programs: a 1-year Certificate in Advanced Lasers, a 2-year Diploma for Photonics Engineering Technician, a 3-year Diploma for Photonics Engineering Technologists and a 4-year Bachelor of Applied Technology - Photonics. Much has been learnt along the way - the crucial need for industrial partner and government support, for example - and many course corrections had to be made (telecom bust, anyone?). The author will share the results of this 10-year journey so far, the lessons learnt, and a view to the next ten years for these programs and photonics education in Ontario in general.

  6. Ten-year results after cementless THA with a sandwich-type alumina ceramic bearing.

    PubMed

    Park, Youn-Soo; Park, Se-Jun; Lim, Seung-Jae

    2010-11-01

    We analyzed the long-term results of a single-surgeon series of 102 cementless total hip arthroplasties (THAs) performed using a sandwich-type alumina ceramic bearing. The prostheses involved a porous-coated acetabular socket, a polyethylene-alumina composite liner, a 28-mm alumina head, and a grit-blasted titanium-alloy stem. Mean patient age at the time of THA was 39 years (range, 18-66 years), and 76% of the patients were younger than 50 years. All procedures were performed with use of the same surgical technique and the same implant at a single center. Mean follow-up was 115 months (range, 84-133 months). When failure was defined as revision of either the acetabular or the femoral component for any reason, Kaplan-Meier survival probability at 10 years was 95.3% (95% confidence interval, 89.5%-100%). Mean Harris Hip Score improved from 47 points (range, 16-70 points) preoperatively to 95 points (range, 85-100 points) at final follow-up. No radiographically detectable osteolysis around the acetabular or femoral component was observed in any hip. No patient reported squeaking in the operated hip. During the follow-up period, 3 hips (3%) required revision surgery; 2 underwent acetabular revision because of a ceramic liner fracture and 1 underwent revision for early loosening of the acetabular cup. Ten-year results of cementless THA with a sandwich-type alumina ceramic bearing were encouraging, and no great increase in ceramic failure rate was observed, which contrasts with the findings of previously reported short-term follow-up studies. PMID:21053885

  7. Ten-year results of a press-fit, porous-coated acetabular component.

    PubMed

    Grobler, G P; Learmonth, I D; Bernstein, B P; Dower, B J

    2005-06-01

    We retrospectively reviewed, ten years after surgery, 100 consecutive total hip replacements in which the Duraloc 300 cup had been used. Post-operative radiographs were analysed for placement of the cup and interface gaps and follow-up radiographs for lucent lines, osteolysis, wear and migration. All the components were found to be stable with no evidence of loosening. The mean rate of wear was 0.12 mm/year. Three hips developed acetabular osteolysis at the level of the apex hole. Two have successfully undergone bone grafting without removal of the implants and one patient is awaiting surgery. The Duraloc 300 cup has a survival of 100% at ten years with no aseptic loosening and a low incidence of pelvic osteolysis. PMID:15911659

  8. Porous-coated acetabular components with screw fixation. Five to ten-year results.

    PubMed

    Latimer, H A; Lachiewicz, P F

    1996-07-01

    The results of 136 consecutive primary total hip arthroplasties performed by one surgeon with the Harris-Galante-I porous-coated acetabular component were reviewed at a mean of seven years (range, five to ten years). In all hips, the outer diameter of the acetabular component was the same as the diameter of the final reamer used in the preparation of the acetabulum. However, this reamer was used only briefly at the rim of the acetabulum, and therefore the components had so-called press-fit stability. A mean of four screws (range, three to six screws) were used for additional fixation of the component. The clinical evaluation was performed with use of the Harris hip score. Standardized anteroposterior radiographs of the pelvis were assessed for migration of the component, radiolucent and radiodense lines, linear wear of the polyethylene, and osteolysis. No acetabular component had been revised for loosening and none were radiographically loose at the time of the most recent follow-up evaluation. There were no complications related to the use of the screws, and no screw had bent or broken. A non-progressive radiolucent line was seen in one acetabular zone in thirty-four hips (25 per cent) and in two acetabular zones in six hips (4 per cent). No hip had a radiolucent line in all three acetabular zones. The mean rate of linear wear of the polyethylene was 0.1 millimeter per year. There was no dissociation of the acetabular liner from the metal shell. Two hips (1 per cent) had asymptomatic osteolysis in the ischium and adjacent to the rim of the acetabular component; this was treated with grafting at the site of the lesion and exchange of the femoral head and the worn polyethylene liner. Five femoral components inserted without cement and one inserted with cement were revised because of loosening. The data suggest that, at a mean of seven years, fixation of this porous-coated component was uniformly excellent. The low prevalence of radiolucent lines and the absence of

  9. Long term compatibility of nitrogen tetroxide with metals - Results at the ten-year milestone

    NASA Technical Reports Server (NTRS)

    Moran, C. M.; Bjorklund, R. A.

    1982-01-01

    Analyses and results are reported of a test program to establish the effects of long-term (10 years or more) contact of materials with nitrogen textroxide MON-1 for the purpose of designing chemical propulsion system components which can be used for current as well as future planetary spacecraft. The test materials included aluminum alloy, corrosion-resistant steel, titanium alloy, and nickel. The weight and appearance of each specimen were observed, including the presence of deposits, etching, pitting, and cracking. Aluminum alloy and steel were rated satisfactory with minor reservations, titanium alloy was satisfactory, and nickel was unsatisfactory. Criteria for ratings are shown.

  10. Ten Years of Results of Modified Frontalis Muscle Transfer for the Correction of Blepharoptosis

    PubMed Central

    Kim, Woo Jeong; Park, Dae Hwan

    2016-01-01

    Background Conventional frontalis transfer may cause a range of complications. In order to overcome complications, we made modifications to the surgical technique, and compared the outcomes of patients who underwent conventional frontalis transfer with those of patients who underwent modified frontalis transfer. Methods We conducted a retrospective study of 48 patients (78 eyes) who underwent conventional frontalis transfer between 1991 and 2003 (group A) and 67 patients (107 eyes) who underwent modified frontalis transfer between 2004 and 2014 (group B). The frontalis transfer procedures were modified conform to the following principles. The tip of the frontalis muscle flap included soft tissue that was as thick as possible and the soft tissue on the tarsal plate was removed to the greatest extent possible. A double fold was created in cases of unilateral ptosis. In order to evaluate the objective effects of modification, preoperative and postoperative values of the marginal distance reflex 1 (MRD1), the corneal exposure area, and the decrease in eyebrow height were compared between the two groups. Results In group A, patients showed an improvement of 1.19 mm in the MRD1, a 6.31% improvement in the corneal exposure area, and a 7.82 mm decrease in eyebrow height. In group B, patients showed an improvement of 2.17 mm in the MRD1, an 8.39% improvement in the corneal exposure area, and an 11.54 mm decrease in eyebrow height. The improvements in group B were significantly greater than those in group A. Conclusions Modified frontalis transfer showed better results than the conventional procedure and provided satisfactory outcomes. PMID:27019810

  11. Color measurements on marble and limestone briquettes exposed to outdoor environment in the Eastern United States. Volume I: Results of exposure 1984-1990

    SciTech Connect

    Reimann, K.J.

    1994-04-01

    In a long-term program that began in 1984, limestone and marble briquettes have been exposed to both anthropogenic acid deposition and natural weathering at four field sites in the eastern United States. Similar tests began at an Ohio site in 1986. Effects of exposure on the briquettes and other materials at the sites are evaluated periodically by several federal agencies cooperating in the National Acid Precipitation Assessment Program (NAPAP). One of the primary contributions of Argonne National Laboratory to the NAPAP has been the measurement of tristimulus color change on samples exposed to the environment. Results from the first six years indicate a yellowing of the marble and a darkening of limestone on both the skyward and groundward surfaces of fresh and preexposed briquettes. The relationship between discoloration and exposure period appears to be linear. Discoloration rates as a function of a cumulative exposure time are almost constant for marble and slightly decreasing for limestone Dark spots on groundward surfaces were measured with tristimulus color equipment prior to chemical analysis to determine if a correlation exists between darkening (change in reflectance) and SO{sub 4} concentration. Taking exposure time into consideration, and assuming that the airborne concentration of dark particles, which cause darkening, is proportional to airborne SO{sub 2} concentration, one can establish a linear relationship between exposure time, darkening, and SO{sub 2} concentration. The program is continuing so that additional data can be obtained.

  12. Titan's Surface at 2.2-Cm Wavelength: Results and Interpretations through the First Ten Years of Observation By Cassini

    NASA Astrophysics Data System (ADS)

    Janssen, M. A.; Le Gall, A. A.; Hayes, A. G., Jr.; Lopes, R. M. C.; Malaska, M. J.

    2014-12-01

    A comprehensive calibration and mapping of the thermal microwave emission from Titan's surface will be presented, based on radiometric data obtained at 2.2-cm wavelength by the passive radiometer in the Cassini Radar instrument through the nearly ten years following Saturn Orbit Insertion. The data reported were accumulated from Titan passes Ta (October 2004) through T98 (February 2014) and now incorporate emission from all of Titan's surface. The mapping will eventually include data at both low and high spatial resolution, while for the present we concentrate on only the low-resolution data that provide thermal polarization. These data are sufficient to examine not only surface effective dielectric constant but seasonal and diurnal surface temperature variations, which we compare with current CIRS results. The map of effective dielectric constant allows us to explore possible regional variations in surface properties and composition. Finally, these data allow us to understand the nature and magnitude of systematic errors in the map-making process, essential to interpreting both the present maps and the forthcoming high-resolution maps based on these. This work was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under a contract with the National Aeronautics and Space Administration.

  13. Ten years of PAMELA

    NASA Astrophysics Data System (ADS)

    Spillantini, Piero

    2016-07-01

    PAMELA results obtained in the ten years of data taking and activity must include other important new measurements, opening the era of precise measurements in cosmic ray observation, such as light elements and isotopes fluxes, the absolute fluxes of protons and antiprotons and light nuclei, and of electrons and positrons, the discovery of a belt of antiprotons trapped in the terrestrial magnetic field, and in the SAA in particular, the fluxes of quasi-trapped electrons and positrons, the time evolution of the energetic tail of spectra of protons and helium nuclei in the powerful solar event of December 13th 2006, and other magnetosphere and solar physics observations. For the future, it must be mentioned the continuation of the activity of PAMELA team. The satellite orbit spans over a significantly large region of the Earth's magnetosphere, making possible a detailed study of its effect on the incoming radiation, in particular in the niche of the observations on the hundred MeV/n and a few GeV/n, where the low energy threshold of the instrument, the precision of the magnetic spectrometer and the resumed activity of the Sun promises to play an important role besides the explores operating in our region of the solar system.

  14. Ten-year results with the Morscher press-fit cup: an uncemented, non-modular, porous-coated cup inserted without screws.

    PubMed

    Garavaglia, Guido; Lübbeke, Anne; Barea, Christophe; Roussos, Constantinos; Peter, Robin; Hoffmeyer, Pierre

    2011-07-01

    Total hip arthroplasty (THA) with well designed cementless acetabular implants has shown excellent results. The purpose of this study was to assess our clinical and radiological outcomes using an uncemented cup. We conducted a prospective cohort study including all consecutive primary THAs performed with the Morscher press-fit cup, an uncemented non-modular acetabular component, between March 1996 and December 1998. Patients were evaluated at ten years with clinical and radiological follow-up, patient satisfaction and questionnaire assessment using the Harris hip score (HHS), Merle d'Aubigné and Postel score, the UCLA score, the 12-item short-form health survey (SF-12) and a visual analog scale. Five hundred sixty-one THAs were performed in 518 patients. At 120 months (± 7.3 months), 303 patients with 335 THAs were still available for follow-up. None of the patients had required cup revision for aseptic loosening. At ten years, the cup survivorship was 98.8% (95% CI 97.4-99.5) with cup revision for any cause as an endpoint. No radiolucencies were seen around the cups, but osteolytic defects involved 21 stems (8.3%). Mean total linear polyethylene wear was 0.9 mm. The Morscher acetabular replacement cup provides excellent results at ten years. There were no revisions for aseptic loosening of the cup, and no osteolytic defects were found around the cup. Patient satisfaction was high and the clinical results were very good. PMID:20524114

  15. Ten-Year Results of Primary and Revision Condylar-Constrained Total Knee Arthroplasty in Patients with Severe Coronal Plane Instability

    PubMed Central

    Camera, Andrea; Biggi, Stefano; Cattaneo, Gabriele; Brusaferri, Giovanni

    2015-01-01

    Objective : To retrospectively review the results at minimum ten years after surgery of a consecutive series of total knee arthroplasties (TKAs) performed using a constrained condylar implant in patients with severe coronal plane instability. Materials and Methods : The series comprised of 44 patients (45 knees) who received primary (19 knees) or revision (26 knees) TKA with a constrained condylar implant between 2001 and 2003 at a single institution. Results : There were no revisions or any other surgery related complications at a mean implantation time of 11.0 years. In 38 patients (15 knees in the primary group and 24 knees in the revision group) who were available for clinico-radiographic follow-up at a minimum of ten years, there was no sign of radiographic loosening. Two patients showed cortical hypertrophy at the extension stem tip but none complained of pain around the stem tip. According to the TLKSS score grading, 73% of the patients in the primary group had results categorized as good or excellent, while 54% of the patients in the revision group had fair results. Four patients (one (7%) in the primary group and three (13%) in the revision group) had poor results. The median WOMAC Index was 80.2% (interquartile range: 74.0% - 81.2%) and 74.0% (interquartile range: 72.1% - 75.8%) in the primary and in the revision groups, respectively (p=0.010). Conclusion : This study showed satisfactory clinical outcomes with no re-operations at minimum ten years after implantation in patients who had undergone primary or revision TKA with a condylar constrained implant. PMID:26401160

  16. Ten-Year Results From the Natrelle 410 Anatomical Form-Stable Silicone Breast Implant Core Study

    PubMed Central

    Maxwell, G. Patrick; Van Natta, Bruce W.; Bengtson, Bradley P.; Murphy, Diane K.

    2015-01-01

    Background Silicone breast implants have long been used for breast augmentation and reconstruction. During this time, these medical devices have gone through a number of modifications to improve their safety, quality, and clinical outcome performance. Objectives The authors conducted a 10-year study to determine the safety and effectiveness of Natrelle 410 silicone breast implants. Methods This prospective, multicenter study enrolled 941 subjects who were undergoing either augmentation, augmentation revision, reconstruction, or reconstruction revision. Data on complications, reoperations, explantations, and subject satisfaction were collected at annual clinic visits, and one-third of subjects underwent biennial magnetic resonance imaging (MRI) to screen for implant rupture. The authors used the Kaplan-Meier estimator to calculate risk rates for local complications, reoperations, and explantations. Results Capsular contracture rates increased approximately 1% per year from the previously reported 6-year rates. The rates were significantly lower than those from the Natrelle round gel core study. The overall rate of confirmed ruptured implants in subjects who underwent MRI was 5.7%. Eleven late seromas were reported. The most common reason for explantation was a subject requesting a size or style change. Satisfaction rates remained high through 10 years, with most subjects saying they were somewhat or definitely satisfied with their implants. Conclusions This 10-year prospective trial demonstrated the long-term safety and effectiveness of Natrelle 410 anatomical form-stable implants. The complication rates were low and the satisfaction rates were high. Level of Evidence: 1 Therapeutic PMID:25717116

  17. Recovery potential of a western lowland gorilla population following a major Ebola outbreak: results from a ten year study.

    PubMed

    Genton, Céline; Cristescu, Romane; Gatti, Sylvain; Levréro, Florence; Bigot, Elodie; Caillaud, Damien; Pierre, Jean-Sébastien; Ménard, Nelly

    2012-01-01

    Investigating the recovery capacity of wildlife populations following demographic crashes is of great interest to ecologists and conservationists. Opportunities to study these aspects are rare due to the difficulty of monitoring populations both before and after a demographic crash. Ebola outbreaks in central Africa have killed up to 95% of the individuals in affected western lowland gorilla (Gorilla gorilla gorilla) populations. Assessing whether and how fast affected populations recover is essential for the conservation of this critically endangered taxon. The gorilla population visiting Lokoué forest clearing, Odzala-Kokoua National Park, Republic of the Congo, has been monitored before, two years after and six years after Ebola affected it in 2004. This allowed us to describe Ebola's short-term and long-term impacts on the structure of the population. The size of the population, which included around 380 gorillas before the Ebola outbreak, dropped to less than 40 individuals after the outbreak. It then remained stable for six years after the outbreak. However, the demographic structure of this small population has significantly changed. Although several solitary males have disappeared, the immigration of adult females, the formation of new breeding groups, and several birth events suggest that the population is showing potential to recover. During the outbreak, surviving adult and subadult females joined old solitary silverbacks. Those females were subsequently observed joining young silverbacks, forming new breeding groups where they later gave birth. Interestingly, some females were observed joining silverbacks that were unlikely to have sired their infant, but no infanticide was observed. The consequences of the Ebola outbreak on the population structure were different two years and six years after the outbreak. Therefore, our results could be used as demographic indicators to detect and date outbreaks that have happened in other, non-monitored gorilla

  18. Recovery Potential of a Western Lowland Gorilla Population following a Major Ebola Outbreak: Results from a Ten Year Study

    PubMed Central

    Gatti, Sylvain; Levréro, Florence; Bigot, Elodie; Caillaud, Damien; Pierre, Jean-Sébastien; Ménard, Nelly

    2012-01-01

    Investigating the recovery capacity of wildlife populations following demographic crashes is of great interest to ecologists and conservationists. Opportunities to study these aspects are rare due to the difficulty of monitoring populations both before and after a demographic crash. Ebola outbreaks in central Africa have killed up to 95% of the individuals in affected western lowland gorilla (Gorilla gorilla gorilla) populations. Assessing whether and how fast affected populations recover is essential for the conservation of this critically endangered taxon. The gorilla population visiting Lokoué forest clearing, Odzala-Kokoua National Park, Republic of the Congo, has been monitored before, two years after and six years after Ebola affected it in 2004. This allowed us to describe Ebola's short-term and long-term impacts on the structure of the population. The size of the population, which included around 380 gorillas before the Ebola outbreak, dropped to less than 40 individuals after the outbreak. It then remained stable for six years after the outbreak. However, the demographic structure of this small population has significantly changed. Although several solitary males have disappeared, the immigration of adult females, the formation of new breeding groups, and several birth events suggest that the population is showing potential to recover. During the outbreak, surviving adult and subadult females joined old solitary silverbacks. Those females were subsequently observed joining young silverbacks, forming new breeding groups where they later gave birth. Interestingly, some females were observed joining silverbacks that were unlikely to have sired their infant, but no infanticide was observed. The consequences of the Ebola outbreak on the population structure were different two years and six years after the outbreak. Therefore, our results could be used as demographic indicators to detect and date outbreaks that have happened in other, non-monitored gorilla

  19. Intonation Comprehension in Ten-Year-Olds.

    ERIC Educational Resources Information Center

    Cruttenden, Alan

    1985-01-01

    Investigates the comprehension of nine intonational contrasts in ten-year-olds and adults. Overall performance on the tasks was much lower among the children than among the adults. Results indicate that hypotheses concerning the chronological order of development of meanings dependent on groupings, nucleus placements, and tones are too simplistic.…

  20. Titan's surface at 2.18-cm wavelength imaged by the Cassini RADAR radiometer: Results and interpretations through the first ten years of observation

    NASA Astrophysics Data System (ADS)

    Janssen, M. A.; Le Gall, A.; Lopes, R. M.; Lorenz, R. D.; Malaska, M. J.; Hayes, A. G.; Neish, C. D.; Solomonidou, A.; Mitchell, K. L.; Radebaugh, J.; Keihm, S. J.; Choukroun, M.; Leyrat, C.; Encrenaz, P. J.; Mastrogiuseppe, M.

    2016-05-01

    A comprehensive calibration and mapping of the thermal microwave emission from Titan's surface is reported based on radiometric data obtained at 2.18-cm wavelength by the passive radiometer included in the Cassini RADAR instrument. Compared to previous work, the present results incorporate the much larger data set obtained in the approximately ten years following Saturn Orbit Insertion. Brightness temperature data including polarization were accumulated by segments in Titan passes from Ta (October 2004) through T98 (February 2014). The observational segments were analyzed to produce a mosaic of effective dielectric constant based on the measurement of thermal polarization covering 76% of the surface, and brightness temperature at normal incidence covering Titan's entire surface. As part of the mosaicking process we also solved for the seasonal variation of physical temperature with latitude, which we found to be smaller by a factor of 0.87 ± 0.05 in relative amplitude compared to that reported in the thermal infrared by Cassini's Composite Infrared Spectrometer (CIRS). We used the equatorial temperature obtained by the Huygens probe and the seasonal dependence with latitude from CIRS to convert the brightness mosaic to absolute emissivity, from which we could infer global thermophysical properties of the surface in combination with the dielectric mosaic. We see strong evidence for subsurface (volume) scattering as a dominant cause of the radar reflectivity in bright regions, and elsewhere a surface composition consistent with the slow deposition and processing of organic compounds from the atmosphere. The presence of water ice in the near subsurface is strongly indicated by the high degree of volume scattering observed in radar-bright regions (e.g., Hummocky/mountainous terrains) constituting ∼10% of Titan's surface. A thermal analysis allowed us to infer a mean 2.18-cm emission depth in the range 40-100 cm for the dominant radar-dark terrains (the remainder of

  1. Gunshot residue, ten years later.

    PubMed

    Wilber, C G; Lantz, R K; Sulik, P L

    1991-09-01

    Gunshot residues may be central to a competent reconstruction of a shooting incident. When a young boy was shot in the neck by a playmate using a .22-caliber single-action revolver, permanent paralysis from mid-thorax downward ensued. Ten years later the victim sued the importer, the vendor, the German manufacturer, and the shooter's family. Investigative reports indicated "horseplay" and questionable emergency medical team care. Depositions were contradictory. The entry wound, removed at surgery, was fixed and processed for slides. The histopathologist referred to "black pigment granules" in the wound track. The 10-year-old slides and block were retrieved. The coverslip was removed from a representative slide that was examined under the scanning, x-ray dispersive microscope. The black granules contained amounts of lead, barium, and antimony far beyond any normal range. The firing range had to have been no greater than 6-12 in (15.24-30.48 cm). The case was promptly settled out of court. PMID:1750390

  2. Ten Years of LibQual: A Study of Qualitative and Quantitative Survey Results at the University of Mississippi 2001-2010

    ERIC Educational Resources Information Center

    Greenwood, Judy T.; Watson, Alex P.; Dennis, Melissa

    2011-01-01

    This article analyzes quantitative adequacy gap scores and coded qualitative comments from LibQual surveys at the University of Mississippi from 2001 to 2010, looking for relationships between library policy changes and LibQual results and any other trends that emerged. Analysis found no relationship between changes in policy and survey results…

  3. Thermophilic spore-forming bacteria isolated from spoiled canned food and their heat resistance. Results of a French ten-year survey.

    PubMed

    André, S; Zuber, F; Remize, F

    2013-07-15

    Thermal processing of Low Acid Canned Foods (LACF), which are safe and shelf-stable at ambient temperature for several years, results in heat inactivation of all vegetative microorganisms and the partial or total inactivation of spores. Good Manufacturing Hygienic Practices include stability tests for managing the pathogen risk related to surviving mesophilic bacterial spores. LACF are also often submitted to additional incubation conditions, typically 55 °C for 7 days, to monitor spoilage by thermophiles. In this study we identified the bacterial species responsible for non-stability after prolonged at 55 °C of incubation of LACF from 455 samples collected from 122 French canneries over 10 years. Bacteria were identified by microsequencing or a recent developed tool for group-specific PCR detection (SporeTraQ™). A single species was identified for 93% of examined samples. Three genera were responsible for more than 80% of all non-stability cases: mostly Moorella (36%) and Geobacillus (35%), and less frequently Thermoanaerobacterium (10%). The other most frequent bacterial genera identified were Bacillus, Thermoanaerobacter, Caldanaerobius, Anoxybacillus, Paenibacillus and Clostridium. Species frequency was dependent on food category, i.e. vegetables, ready-made meals containing meat, seafood or other recipes, products containing fatty duck, and related to the intensity of the thermal treatment applied in these food categories. The spore heat resistance parameters (D or δ and z values) from 36 strains isolated in this study were determined. Taken together, our results single out the species most suitable for use as indicators for thermal process settings. This extensively-documented survey of the species that cause non-stability at 55 °C in LACF will help canneries to improve the management of microbial contamination. PMID:23728430

  4. Ten Year Operating Test Results and Post-Test Analysis of a 1/10 Segment Stirling Sodium Heat Pipe, Phase III

    NASA Technical Reports Server (NTRS)

    Rosenfeld, John, H; Minnerly, Kenneth, G; Dyson, Christopher, M.

    2012-01-01

    High-temperature heat pipes are being evaluated for use in energy conversion applications such as fuel cells, gas turbine re-combustors, Stirling cycle heat sources; and with the resurgence of space nuclear power both as reactor heat removal elements and as radiator elements. Long operating life and reliable performance are critical requirements for these applications. Accordingly, long-term materials compatibility is being evaluated through the use of high-temperature life test heat pipes. Thermacore, Inc., has carried out a sodium heat pipe 10-year life test to establish long-term operating reliability. Sodium heat pipes have demonstrated favorable materials compatibility and heat transport characteristics at high operating temperatures in air over long time periods. A representative one-tenth segment Stirling Space Power Converter heat pipe with an Inconel 718 envelope and a stainless steel screen wick has operated for over 87,000 hr (10 yr) at nearly 700 C. These life test results have demonstrated the potential for high-temperature heat pipes to serve as reliable energy conversion system components for power applications that require long operating lifetime with high reliability. Detailed design specifications, operating history, and post-test analysis of the heat pipe and sodium working fluid are described.

  5. Ten Years of Near-Surface-Sensitive Satellite Observations of Carbon Dioxide and Methane: Selected Results Related to Natural and Anthropogenic Sources and Sinks

    NASA Astrophysics Data System (ADS)

    Buchwitz, M. A.; Reuter, M.; Schneising, O.; Bovensmann, H.; Burrows, J. P.

    2014-12-01

    Prior to the recently successfully launched OCO-2 mission, global near-surface-sensitive satellite observations of carbon dioxide (CO2) have been made with SCIAMACHY/ENVISAT during 2002-2012 and are still being made since 2009 with TANSO-FTS/GOSAT, which also deliver atmospheric methane (CH4). The SCIAMACHY and GOSAT overlapping time series of atmospheric column-averaged mole fractions, i.e., XCO2 and XCH4, now cover more than 10 years. During the last years significant progress has been made in improving the quality of the XCO2 and XCH4 data products retrieved from SCIAMACHY and GOSAT and in extending the time series so that more and more applications can be addressed. In this presentation we present some recent results related to CO2 and CH4 sources and sinks. The SCIAMACHY products have been generated using retrieval algorithms developed at University of Bremen. For XCO2 we use an ensemble of data products generated using GOSAT retrieval algorithms developed in Japan (at NIES), in the US (at NASA/JPL and collaborating institutes) and at European institutions (University of Leicester, UK, and SRON, Netherlands, in collaboration with KIT, Germany). Focus will be on three applications: (i) An assessment of the strength of the European terrestrial carbon sink during 2003-2010 based on an ensemble of SCIAMACHY (2003-2010) and GOSAT (2010) XCO2 data products, (ii) an assessment of CO2 and NO2 anthropogenic emission and emission ratio trends using co-located SCIAMACHY XCO2 and NO2 observations over Europe, North America and East Asia, and (iii) an analysis of SCIAMACHY XCH4 retrievals during 2006-2011 over North America focusing on fugitive methane emissions from oil and gas production using tight geological formations ("fracking"). It will be shown that (i) the European terrestrial carbon sink appears to be stronger than expected, (ii) that recent Chinese CO2 and NO2 emissions are increasing but with a trend towards reduced NO2-to-CO2 emission ratios pointing to

  6. Ten years of the Spanish Virtual Observatory

    NASA Astrophysics Data System (ADS)

    Solano, E.

    2015-05-01

    The main objective of the Virtual Observatory (VO) is to guarantee an easy and efficient access and analysis of the information hosted in astronomical archives. The Spanish Virtual Observatory (SVO) is a project that was born in 2004 with the goal of promoting and coordinating the VO-related activities at national level. SVO is also the national contact point for the international VO initiatives, in particular the International Virtual Observatory Alliance (IVOA) and the Euro-VO project. The project, led by Centro de Astrobiología (INTA-CSIC), is structured around four major topics: a) VO compliance of astronomical archives, b) VO-science, c) VO- and data mining-tools, and d) Education and outreach. In this paper I will describe the most important results obtained by the Spanish Virtual Observatory in its first ten years of life as well as the future lines of work.

  7. The first ten years of Swift supernovae

    NASA Astrophysics Data System (ADS)

    Brown, Peter J.; Roming, Peter W. A.; Milne, Peter A.

    2015-09-01

    The Swift Gamma Ray Burst Explorer has proven to be an incredible platform for studying the multiwavelength properties of supernova explosions. In its first ten years, Swift has observed over three hundred supernovae. The ultraviolet observations reveal a complex diversity of behavior across supernova types and classes. Even amongst the standard candle type Ia supernovae, ultraviolet observations reveal distinct groups. When the UVOT data is combined with higher redshift optical data, the relative populations of these groups appear to change with redshift. Among core-collapse supernovae, Swift discovered the shock breakout of two supernovae and the Swift data show a diversity in the cooling phase of the shock breakout of supernovae discovered from the ground and promptly followed up with Swift. Swift observations have resulted in an incredible dataset of UV and X-ray data for comparison with high-redshift supernova observations and theoretical models. Swift's supernova program has the potential to dramatically improve our understanding of stellar life and death as well as the history of our universe.

  8. The Currie Report: Ten Years Later.

    ERIC Educational Resources Information Center

    Ewing, John L.

    1972-01-01

    The Currie Report, or the Report of the Commission on Education in New Zealand, which appeared in 1962, has been generating changes on a broad front within the New Zealand educational system throughout the last ten years. Eight areas of concern were identified by that Commission. The "most clamant" was the recruitment and training of teachers.…

  9. Preparing Future Faculty: Ten Years Later

    ERIC Educational Resources Information Center

    Murphy, Sean P.; Aiossa, Elizabeth; Winter, Mary Mugica

    2010-01-01

    When Sean Murphy designed the Graduate Student Internship Program at the College of Lake County (CLC), his 2001 TETYC article about the then two-year-old program detailed his programmatic response to the job market. Ten years later, the CLC-DePaul University partnership remains the strongest of the original dozen cross-sector relationships CLC…

  10. The AJAE: Preoccupations through Ten Years.

    ERIC Educational Resources Information Center

    Long, Peter

    1983-01-01

    This survey is a retrospective analysis of ten years of articles published in the Australian Journal of Adult Education. The years 1970-1979 were chosen to cover the decade of the seventies: a decade that was significant for adult education in a number of ways. (SSH)

  11. Ten year planetary ephemeris: 1986-1995

    NASA Technical Reports Server (NTRS)

    Espenak, F.

    1986-01-01

    Accurate geocentric positions are tabulated at five day intervals for the Sun, Mercury, Venus, Mars, Jupiter, Saturn, Uranus and Neptune during the ten year period 1986 through 1995. The apparent angular diameters, radial velocities, declinations and mean times of meridian transit of the seven planets and the Sun are graphically depicted for each year in the interval. Appendices are included which discuss the theory of planetary orbits and a FORTRAN program for calculating planetary ephemerides.

  12. Reference Success: What Has Changed over the Past Ten Years?

    ERIC Educational Resources Information Center

    Baker, Lynda M.; Field, Judith J.

    2000-01-01

    Describes a study that replicated two earlier studies to determine whether environmental factors of reference departments and behavioral characteristics of references staff members had changed over the past ten years. Results emphasize the need for more and better education and training in conducting reference interviews and providing client…

  13. Ten Years of Infrasound Observation in Korea

    NASA Astrophysics Data System (ADS)

    Lee, Hee-Il; Che, Il-Young; Kim, Tae Sung

    2010-05-01

    Over the ten years after the installation of our first seismo-acoustic array station (CHNAR) in September 1999, Korea Institute of Geoscience and Mineral Resources (KIGAM) has been continuously observing infrasound with an infrasound array network, named KIN (Korean Infrasound Network) in Korea. This network consists of seven seismo-acoustic arrays (BRDAR, KMPAR, CHNAR, YAGAR, KSGAR, ULDAR and TJIAR). The aperture size of the smallest array (KMPAR and TJIAR) is about 300m and the largest is about 1.4km. The number of acoustic gauges are between 4 (TJIAR) and 18 (YAGAR), and 1 or 5 seismometers are collocated at the center of the acoustic array. All seismic and infrasonic signals of the arrays are digitized at 40 samples/sec and transmitted to KIGAM in real time. Many interesting infrasound signals associated with different kind of anthropogenic source as well as natural one are detected by KIN. Ten years of seismo-acoustic data are analyzed by using PMCC program, and identified more than five thousand of infrasonic events and catalogued in our infrasound database. This database is used to study characteristics of seasonally dependent propagation of the infrasound wave in local scale, as well as to better understand how atmospheric condition affects the detection ratio at a specific station throughout the year. It also played a valuable role in discriminating the anthropogenic events such as the second nuclear test on 25 May 2009 in North Korea, from natural earthquakes, which is important in estimating the seismicity in Korea.

  14. Ten-Year Changes in the Prevalence and Socio-Demographic Determinants of Physical Activity among Polish Adults Aged 20 to 74 Years. Results of the National Multicenter Health Surveys WOBASZ (2003-2005) and WOBASZ II (2013-2014)

    PubMed Central

    Kwaśniewska, Magdalena; Pikala, Małgorzata; Bielecki, Wojciech; Dziankowska-Zaborszczyk, Elżbieta; Rębowska, Ewa; Kozakiewicz, Krystyna; Pająk, Andrzej; Piwoński, Jerzy; Tykarski, Andrzej; Zdrojewski, Tomasz; Drygas, Wojciech

    2016-01-01

    Introduction The aim of the study was to estimate ten-year changes in physical activity (PA) patterns and sociodemographic determinants among adult residents of Poland. Methods The study comprised two independent samples of randomly selected adults aged 20–74 years participating in the National Multicentre Health Survey WOBASZ (2003–2005; n = 14572) and WOBASZ II (2013–2014; n = 5694). In both surveys the measurements were performed by six academic centers in all 16 voivodships of Poland (108 measurement points in each survey). Sociodemographic data were collected by an interviewer-administered questionnaire in both surveys. Physical activity was assessed in three domains: leisure-time, occupational and commuting physical activity. Results Leisure-time PA changed substantially between the surveys (p<0.001). The prevalence of subjects being active on most days of week fell in both genders in the years 2003–2014 (37.4% vs 27.3% in men); 32.7% vs 28.3% in women. None or occasional activity increased from 49.6% to 56.8% in men, while remained stable in women (55.2% vs 54.9%). In both WOBASZ surveys the likelihood of physical inactivity was higher in less educated individuals, smokers and those living in large agglomerations (p<0.01). No significant changes were observed in occupational activity in men between the surveys, while in women percentage of sedentary work increased from 43.4% to % 49.4% (p<0.01). Commuting PA decreased significantly in both genders (p<0.001). About 79.3% of men and 71.3% of women reported no active commuting in the WOBASZ II survey. Conclusions The observed unfavourable changes in PA emphasize the need for novel intervention concepts in order to reverse this direction. Further detailed monitoring of PA patterns in Poland is of particular importance. PMID:27272130

  15. Women in Astronomy II: Ten Years After

    NASA Technical Reports Server (NTRS)

    Sargent, Wallace

    2004-01-01

    The meeting "Women in Astronomy II: Ten Years After" took place at the California Institute of Technology in Pasadena, CA June 27-28, 2003. The meeting was sponsored by the Committee on the Status of Women of the American Astronomical Society and was attended by about 155 participants. The purpose of the meeting was: "To review the current status of women in astronomy, understand their work environment, assess development since the 1992 Baltimore conference, and recommend future actions that will improve the environment for all astronomers." A description of the meeting and its background can be found at http://www.aas.org/%7Ecswa/WIA2003.html. The proceedings are being edited by Profs. Meg Urry (Yale University) and Ran Bagenal (University of Colorado). The principal outcome of WIAII was a series of recommendations, "The Pasadena Recommendations", which have been approved by the AAS Council and which can be found at http://www.aas.org/%7Ecswa/.

  16. Ten Years of ENA Imaging from Cassini

    NASA Astrophysics Data System (ADS)

    Brandt, Pontus; Mitchell, Donald; Westlake, Joseph; Carbary, James; Paranicas, Christopher; Mauk, Barry; Krimigis, Stamatios

    2014-05-01

    In this presentation we will provide a detailed review of the science highlights of the ENA observations obtained by The Ion Neutral Camera (INCA) on board Cassini. Since the launch of Cassini, INCA has unveiled an invisible world of hot plasma and neutral gas of the two biggest objects of our solar system: the giant magnetosphere of Jupiter and Saturn. Although more than ten years ago, INCA captured the first ENA images of the Jovian system revealing magnetospheric dynamics and an asymmetric Europa neutral gas torus. Approaching Saturn, INCA observed variability of Saturn's magnetospheric activity in response to changes in solar wind dynamic pressure, which was contrary to expectations and current theories. In orbit around Saturn, INCA continued the surprises including the first imaging and global characterization of Titan's exosphere extended out to its gravitational Hill sphere; recurring injections correlating with periodic Saturn Kilometric Radiation (SKR) bursts and magnetic field perturbations; and the discovery of energetic ionospheric outflow. Perhaps most significant, and the focal point of this presentation, is INCA's contribution to the understanding of global magnetospheric particle acceleration and transport, where the combination between ENA imaging and in-situ measurements have demonstrated that transport and acceleration of plasma is likely to occur in a two-step process. First, large-scale injections in the post-midnight sector accelerate and transport plasma in to about 12 RS up to energies of several hundreds of keV. Second, centrifugal interchange acts on the plasma inside of this region and provides further heating and transport in to about 6RS. We discuss this finding in the context of the two fundamental types of injections (or ENA intensifications) that INCA has revealed during its ten years of imaging. The first type is large-scale injections appearing beyond 12 RS in the post-midnight sector that have in many cases had an inward component

  17. Ten years of Lusi: A review

    NASA Astrophysics Data System (ADS)

    Miller, Stephen A.

    2016-04-01

    The Lusi mud eruption has continued uninterrupted for ten years, settling into its current steady-state as a quasi-periodic geyser system. Many past, current, and future studies aim to quantify this system, which increasing evidence suggests is a new-born, tectonic scale hydrothermal system linked to the nearby volcano complex. The debate about whether the triggering of Lusi was a natural event of rather caused by drilling continues, but evidence mounts from the behavior of this system that an anthropogenic cause is highly unlikely. Understanding this system is very important because of its social and economic impact on the surrounding communities, and whether it poses future geohazards in the region from future eruptions. A large effort of infrastructures and constant maintenance activity has been and is being conducted inside the 7km2 mud flooded area. This region is framed by a tall embankment that contains the erupted mud and protects the surrounding settlements. This system is also very important for understanding at a larger scale volcanic hydrothermal systems, and to determine whether this new geothermal resource might be exploited. A large effort is underway from an EU-grant supporting the Lusi-Lab project (CEED, University of Oslo) and an SNF grant supporting the University of Neuchatel to study this system from geochemical, geophysical, and modeling perspectives. This review talk summarizes what is known, what is still unclear, and will revisit the behavior of Lusi since its inception.

  18. Lessons learned from ten years of distance learning outreach*

    PubMed Central

    Locatis, Craig; Gaines, Cynthia; Liu, Wei-Li; Gill, Michael; Ackerman, Michael

    2015-01-01

    Objective: The study tested the efficacy of providing distance learning with real-time videoconferencing to broaden high school student knowledge of health careers. Methods: A pilot program was tried out and extended over ten years to include other schools in four different time zones and the National Library of Medicine. Survey results, site visits, and continued school participation were used as effectiveness indicators. Student ratings, site visits, and ongoing discussions were used to evaluate critical factors in the program. Results: Nine program factors contributed to success. Conclusions: Synchronous communication can be effective for outreach to special populations given appropriate infrastructure, technology, program design, and implementation. PMID:25918486

  19. The Chernobyl accident ten years later

    SciTech Connect

    Squires, D.J.

    1996-12-31

    On April 26, 1986 at 1:23 AM a fire and explosion occurred at the fourth unit of the Chernobyl Nuclear Power Plant Complex, located in the Ukraine, that resulted in the destruction of the reactor core and most of the building in which it was housed. Several environmental impacts resulting from the accident will be discussed in this paper, which will include the effects on plant and wild life, radioactive waste generated and stored or disposed of, effects of evacuations relating to residents within the subsequently established 10km and 30km control zones, impacts of the emergency containment structure (sarcophagus), and potential effects on world opinion and future development of nuclear power. As an immediate result of the fire, 31 people died (2 from the fire & smoke, and 29 from excessive radiation); 237 cases of acute radiation sickness occurred; the total fatalities based upon induced chronic diseases as a result of the accident is unknown: more than 100,000 people were evacuated from within the subsequently established 30 km control zone; in excess of 50 million curies of radionuclides that included finely dispersed nuclear fuel, fragments of graphite, concrete and other building materials were released from the reactor into the environment; an estimated one million cubic meters of radioactive waste were generated (LLW, ILW, HLW); more than 5000 tons of materials (sand, boron, dolomite, cement, and lead) were used to put the fire out by helicopter; shutdown of the adjacent power plants were performed; and other environmental impacts occurred. The Chernobyl Nuclear Power Plant Unit No 4 is an RBMK-1000. It initiated operations in 1983, it was a 1000 MWe with a power output of 3200 MW(th), the reactor core contained 190 MT of fuel, with 1659 assemblies (plus 211 control rods), the average burnup rate was 10.3 MWd/kg, and the reactor operated on a continuous basis with maintenance and fuel reload performed during operations.

  20. Redefining Assessment? The First Ten Years of Assessment in Education

    ERIC Educational Resources Information Center

    Broadfoot, Patricia; Black, Paul

    2004-01-01

    The completion of the first ten years of this journal is an occasion for review and reflection. The main issues that have been addressed over the ten years are summarized in four main sections: Purposes, International Trends, Quality Concerns and Assessment for Learning. Each of these illustrates the underlying significance of the themes of…

  1. Minimally invasive thyroidectomy: a ten years experience

    PubMed Central

    Viani, Lorenzo; Montana, Chiara Montana; Cozzani, Federico; Sianesi, Mario

    2016-01-01

    Background The conventional thyroidectomy is the most frequent surgical procedure for thyroidal surgical disease. From several years were introduced minimally invasive approaches to thyroid surgery. These new procedures improved the incidence of postoperative pain, cosmetic results, patient’s quality of life, postoperative morbidity. The mini invasive video-assisted thyroidectomy (MIVAT) is a minimally invasive procedure that uses a minicervicotomy to treat thyroidal diseases. Methods We present our experience on 497 consecutively treated patients with MIVAT technique. We analyzed the mean age, sex, mean operative time, rate of bleeding, hypocalcemia, transitory and definitive nerve palsy (6 months after the procedure), postoperative pain scale from 0 to 10 at 1 hour and 24 hours after surgery, mean hospital stay. Results The indications to treat were related to preoperative diagnosis: 182 THYR 6, 184 THYR 3–4, 27 plummer, 24 basedow, 28 toxic goiter, 52 goiter. On 497 cases we have reported 1 case of bleeding (0,2%), 12 (2,4%) cases of transitory nerve palsy and 4 (0,8%) definitive nerve palsy. The rate of serologic hypocalcemia was 24.9% (124 cases) and clinical in 7.2% (36 cases); 1 case of hypoparathyroidism (0.2%). Conclusions The MIVAT is a safe approach to surgical thyroid disease, the cost are similar to CT as the adverse events. The minicervicotomy is really a minimally invasive tissue dissection. PMID:27294036

  2. Ten years of leptin replacement therapy.

    PubMed

    Paz-Filho, G; Wong, M-L; Licinio, J

    2011-05-01

    Leptin is a pleiotropic cytokine-like hormone that is involved in the regulation of energy intake and expenditure, neuroendocrine function, immunity and lipid and glucose metabolism. The few humans with genetically based leptin deficiency provide a unique model to assess those effects. We have identified five Turkish patients (one male and two female adults; one boy and one girl) with congenital leptin deficiency due to a missense mutation in the leptin gene. Four of these patients were treated with physiological doses of recombinant methionyl human leptin. Body composition, brain structure and function, behaviour, immunity and endocrine and metabolic parameters were evaluated before and during treatment. Our results showed that leptin has peripheral, hypothalamic and extra-hypothalamic effects. Within the endocrine system, leptin regulates the circadian rhythms of cortisol, thyroid-stimulating hormone, luteinizing hormone and follicle-stimulating hormone. In the brain, leptin controls energy balance and body weight, and plays a role on neurogenesis and brain function. Leptin is a key element of the adiposinsular axis, enhances immune response, and regulates inflammation, coagulation, fibrinolysis and platelet aggregation. Our 10-year experience in treating these unique patients provided valuable data on the peripheral and central effects of leptin. Those results can be taken into account for the development of leptin-based therapies for other diseases. PMID:21410864

  3. BioModels: ten-year anniversary

    PubMed Central

    Chelliah, Vijayalakshmi; Juty, Nick; Ajmera, Ishan; Ali, Raza; Dumousseau, Marine; Glont, Mihai; Hucka, Michael; Jalowicki, Gaël; Keating, Sarah; Knight-Schrijver, Vincent; Lloret-Villas, Audald; Natarajan, Kedar Nath; Pettit, Jean-Baptiste; Rodriguez, Nicolas; Schubert, Michael; Wimalaratne, Sarala M.; Zhao, Yangyang; Hermjakob, Henning; Le Novère, Nicolas; Laibe, Camille

    2015-01-01

    BioModels (http://www.ebi.ac.uk/biomodels/) is a repository of mathematical models of biological processes. A large set of models is curated to verify both correspondence to the biological process that the model seeks to represent, and reproducibility of the simulation results as described in the corresponding peer-reviewed publication. Many models submitted to the database are annotated, cross-referencing its components to external resources such as database records, and terms from controlled vocabularies and ontologies. BioModels comprises two main branches: one is composed of models derived from literature, while the second is generated through automated processes. BioModels currently hosts over 1200 models derived directly from the literature, as well as in excess of 140 000 models automatically generated from pathway resources. This represents an approximate 60-fold growth for literature-based model numbers alone, since BioModels’ first release a decade ago. This article describes updates to the resource over this period, which include changes to the user interface, the annotation profiles of models in the curation pipeline, major infrastructure changes, ability to perform online simulations and the availability of model content in Linked Data form. We also outline planned improvements to cope with a diverse array of new challenges. PMID:25414348

  4. The Virtual Physiological Human: Ten Years After.

    PubMed

    Viceconti, Marco; Hunter, Peter

    2016-07-11

    Biomedical research and clinical practice are struggling to cope with the growing complexity that the progress of health care involves. The most challenging diseases, those with the largest socioeconomic impact (cardiovascular conditions; musculoskeletal conditions; cancer; metabolic, immunity, and neurodegenerative conditions), are all characterized by a complex genotype-phenotype interaction and by a "systemic" nature that poses a challenge to the traditional reductionist approach. In 2005 a small group of researchers discussed how the vision of computational physiology promoted by the Physiome Project could be translated into clinical practice and formally proposed the term Virtual Physiological Human. Our knowledge about these diseases is fragmentary, as it is associated with molecular and cellular processes on the one hand and with tissue and organ phenotype changes (related to clinical symptoms of disease conditions) on the other. The problem could be solved if we could capture all these fragments of knowledge into predictive models and then compose them into hypermodels that help us tame the complexity that such systemic behavior involves. In 2005 this was simply not possible-the necessary methods and technologies were not available. Now, 10 years later, it seems the right time to reflect on the original vision, the results achieved so far, and what remains to be done. PMID:27420570

  5. Ten Years of Tamoxifen Reduces Breast Cancer Recurrences, Improves Survival

    MedlinePlus

    ... Cancer Screening Research Ten Years of Tamoxifen Reduces Breast Cancer Recurrences, Improves Survival For some women with breast ... took it for 5 years. (See the table.) Breast Cancer Recurrence and Death 5 to 14 Years after ...

  6. Regional differences in the distribution of suicide in the former Soviet Union during perestroika, 1984-1990.

    PubMed

    Wasserman, D; Värnik, A; Dankowicz, M

    1998-01-01

    The former USSR covered 22.4 million square kilometres and had a population of 288,362,296 in 1990. During 1984-1990 the former USSR consisted of 15 republics, which formed culturally, geographically and historically different regions. Yearly, approximately 45,000-50,000 males and 14,000-15,000 females committed suicide. Suicide rates in the former USSR during 1984-1990 varied greatly between different regions, from 3.5 cases per 100,000 inhabitants in the Caucasus (Georgia, Azerbaijan and Armenia) to 11.8 in Central Asia (Kazakhstan, Kirgizia, Turkmenistan, Uzbekistan and Tajikistan), 18.1 in Moldova, 25.6 in the Slavic region (Russia, the Ukraine and Belarus) and 28.0 in the Baltic region (Latvia, Lithuania and Estonia). The same pattern of great variation between different regions was observed for both men and women in the former USSR, with suicide rates for men ranging from 4.9 in the Caucasian region to 45.9 in the Baltics, and suicide rates for women ranging from 2.1 in the Caucasus to 12.3 in the Baltics. PMID:9825012

  7. In favour of the definition "adolescents with idiopathic scoliosis": juvenile and adolescent idiopathic scoliosis braced after ten years of age, do not show different end results. SOSORT award winner 2014

    PubMed Central

    2014-01-01

    Background The most important factor discriminating juvenile (JIS) from adolescent idiopathic scoliosis (AIS) is the risk of deformity progression. Brace treatment can change natural history, even when risk of progression is high. The aim of this study was to compare the end of growth results of JIS subjects, treated after 10 years of age, with final results of AIS. Methods Design: prospective observational controlled cohort study nested in a prospective database. Setting: outpatient tertiary referral clinic specialized in conservative treatment of spinal deformities. Inclusion criteria: idiopathic scoliosis; European Risser 0–2; 25 degrees to 45 degrees Cobb; start treatment age: 10 years or more, never treated before. Exclusion criteria: secondary scoliosis, neurological etiology, prior treatment for scoliosis (brace or surgery). Groups: 27 patients met the inclusion criteria for the AJIS, (Juvenile Idiopathic Scoliosis treated in adolescence), demonstrated by an x-ray before 10 year of age, and treatment start after 10 years of age. AIS group included 45 adolescents with a diagnostic x-ray made after the threshold of age 10 years. Results at the end of growth were analysed; the threshold of 5 Cobb degree to define worsened, improved and stabilized curves was considered. Statistics: Mean and SD were used for descriptive statistics of clinical and radiographic changes. Relative Risk of failure (RR), Chi-square and T-test of all data was calculated to find differences among the two groups. 95% Confidence Interval (CI) , and of radiographic changes have been calculated. Results We did not find any Cobb angle significant differences among groups at baseline and at the end of treatment. The only difference was in the number of patients progressed above 45 degrees, found in the JIS group. The RR of progression of AJIS was, 1.35 (IC95% 0.57-3.17) versus AIS, and it wasn't statistically significant in the AJIS group, in respect to AIS group (p = 0.5338). Conclusion

  8. Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with Juvenile Idiopathic Arthritis: results from the childhood arthritis prospective Study

    PubMed Central

    McErlane, Flora; Foster, Helen E.; Carrasco, Roberto; Baildam, Eileen M.; Chieng, S. E. Alice; Davidson, Joyce E.; Ioannou, Yiannis; Wedderburn, Lucy R.; Thomson, Wendy

    2016-01-01

    Objectives. The medical management of JIA has advanced significantly over the past 10 years. It is not known whether these changes have impacted on outcomes. The aim of this analysis was to identify and describe trends in referral times, treatment times and 1-year outcomes over a 10-year period among children with JIA enrolled in the Childhood Arthritis Prospective Study. Methods. The Childhood Arthritis Prospective Study is a prospective inception cohort of children with new-onset inflammatory arthritis. Analysis included all children recruited in 2001–11 with at least 1 year of follow-up, divided into four groups by year of diagnosis. Median referral time, baseline disease pattern (oligoarticular, polyarticular or systemic onset) and time to first definitive treatment were compared between groups. Where possible, clinical juvenile arthritis disease activity score (cJADAS) cut-offs were applied at 1 year. Results. One thousand and sixty-six children were included in the analysis. The median time from symptom onset and referral to first paediatric rheumatology appointment (22.7–24.7 and 3.4–4.7 weeks, respectively) did not vary significantly (∼20% seen within 10 weeks of onset and ∼50% within 4 weeks of referral). For oligoarticular and polyarticular disease, 33.8–47 and 25.4–34.9%, respectively, achieved inactive disease by 1 year, with ∼30% in high disease activity at 1 year. A positive trend towards earlier definitive treatment reached significance in oligoarticular and polyarticular pattern disease. Conclusion. Children with new-onset JIA have a persistent delay in access to paediatric rheumatology care, with one-third in high disease activity at 1 year and no significant improvement over the past 10 years. Contributing factors may include service pressures and poor awareness. Further research is necessary to gain a better understanding and improve important clinical outcomes. PMID:27016664

  9. Use of interactive lecture demonstrations: A ten year study

    NASA Astrophysics Data System (ADS)

    Sharma, Manjula D.; Johnston, Ian D.; Johnston, Helen; Varvell, Kevin; Robertson, Gordon; Hopkins, Andrew; Stewart, Chris; Cooper, Ian; Thornton, Ronald

    2010-07-01

    The widely held constructivist view of learning advocates student engagement via interactivity. Within the physics education research community, several specific interactive strategies have been developed to enhance conceptual understanding. One such strategy, the Interactive Lecture Demonstration (ILD) is designed for large lecture classes and, if measured using specific conceptual surveys, is purported to provide learning gains of up to 80%. This paper reports on learning gains for two different Projects over ten years. In Project 1, the ILDs were implemented from 1999 to 2001 with students who had successfully completed senior high school physics. The learning gains for students not exposed to the ILDs were in the range 13% to 16% while those for students exposed to the ILDs was 31% to 50%. In Project 2, the ILDs were implemented from 2007 to 2009 with students who had not studied senior high school physics. Since the use of ILDs in Project 1 had produced positive results, ethical considerations dictated that all students be exposed to ILDs. The learning gains were from 28% to 42%. On the one hand it is pleasing to note that there is an increase in learning gains, yet on the other, we note that the gains are nowhere near the claimed 80%. This paper also reports on teacher experiences of using the ILDs, in Project 2.

  10. Ten years in the library: new data confirm paleontological patterns

    NASA Technical Reports Server (NTRS)

    Sepkoski, J. J. Jr; Sepkoski JJ, J. r. (Principal Investigator)

    1993-01-01

    A comparison is made between compilations of times of origination and extinction of fossil marine animal families published in 1982 and 1992. As a result of ten years of library research, half of the information in the compendia has changed: families have been added and deleted, low-resolution stratigraphic data been improved, and intervals of origination and extinction have been altered. Despite these changes, apparent macroevolutionary patterns for the entire marine fauna have remained constant. Diversity curves compiled from the two data bases are very similar, with a goodness-of-fit of 99%; the principal difference is that the 1992 curve averages 13% higher than the older curve. Both numbers and percentages of origination and extinction also match well, with fits ranging from 83% to 95%. All major events of radiation and extinction are identical. Therefore, errors in large paleontological data bases and arbitrariness of included taxa are not necessarily impediments to the analysis of pattern in the fossil record, so long as the data are sufficiently numerous.

  11. The First Ten Years. National Sea Grant College Program.

    ERIC Educational Resources Information Center

    Hull, E. W. Seabrook

    Detailed are the first ten years of the Sea Grant Program through 1976. The review is divided into three parts. Part I, Sea Grant Origin and Process, traces the historical development of the program and cites the program's philosophy. Part II, Sea Grant in Action, discusses marine resource development, marine technology, research and development,…

  12. Ten Years after Columbine: The Tragedy of Youth Deepens

    ERIC Educational Resources Information Center

    Giroux, Henry A.

    2009-01-01

    For young people it just gets worse. Ten years after the Columbine tragedy, the debate over school safety has clearly shown that educators, parents, politicians, and the mainstream media have created the conditions in which young people have increasingly become the victims of adult mistreatment, indifference, neglect, even violence. The tragic…

  13. Inclusive Education in Australia Ten Years after Salamanca

    ERIC Educational Resources Information Center

    Forlin, Chris

    2006-01-01

    While many states and territories in Australia were initially a little slow to develop a strong momentum towards inclusive educational practices, this has been addressed quite dramatically in the past ten years. Acknowledging that each jurisdiction in Australia has its own department of education and determines its own educational directions this…

  14. Ten Years Timing of Millisecond Pulsars at Kalyazin

    NASA Astrophysics Data System (ADS)

    Ilyasov, Yu. P.; Oreshko, V. V.

    2006-08-01

    Precise timing of millisecond binary pulsars has been started at Kalyazin radio astronomical observatory since 1995. (Tver' region, Russia). Binary pulsars: J0613-02, J1020+10, J1640+22, J1643-12, J1713+07, J2145-07 and isolated millisecond pulsar B1937+21 have been included among the Kalayazin Pulsar Timing Array (KPTA). The Backer's pulsar B1937+21 is being monitored at Kalyazin observatory (0.6 GHz) and Kashima space research centre of the National Institute of Communication Technology (NICT, Japan) (2.2 GHz) simultaneously from 1996, as well. .At Kalyazin pulsars are observed at 0.6 GHz by a full steerable 64-m dish radio telescope RT-64 of the Special Research Bureau of the Moscow Power Engineering Institute. Filter-bank receiver of PRAO Lebedev Physical Institute is used for observations in two circular polarizations by 80 channels per each. Bandwidth per channel is 40 kHz, so total band is 3.2 MHz and time resolution is about 10 μs per channel. Now a perfect data base of pulses Time of Arrival (TOA) are collected with refer to the Solar system barycenter for about 10 years period. Main aim is: a) to study Pulsar Time and to establish a long-term standard of time based on pulsars ensemble as space long life clock alternative to atomic standards; b) to detect gravitational waves extremely low frequency belong to the Gravity Wave Background - GWB. After ten years monitoring of B1937+21 its timing noise is looking as "white phase noise" with RMS about 1.8 μs.( Fractional instability is about 6.10^-15). After these data and timing results of binary pulsar J1640+22 gravitational natural GWB upper limit should be reduced till to less than Ω[g]h^2 <10^-7-10^ -9 . Secular changes of DM toward millisecond pulsar B1937+21 was revealed after long time two frequency timing observations (Kalyazin -0,6 and Kashima -2.3).

  15. Educational Virtual Environments: A Ten-Year Review of Empirical Research (1999-2009)

    ERIC Educational Resources Information Center

    Mikropoulos, Tassos A.; Natsis, Antonis

    2011-01-01

    This study is a ten-year critical review of empirical research on the educational applications of Virtual Reality (VR). Results show that although the majority of the 53 reviewed articles refer to science and mathematics, researchers from social sciences also seem to appreciate the educational value of VR and incorporate their learning goals in…

  16. Adoption of Educational Technology Ten Years after Setting Strategic Goals: A Canadian University Case

    ERIC Educational Resources Information Center

    Zhou, George; Xu, Judy

    2007-01-01

    Through surveys, focus groups and interviews, this study examines technology adoption at a large Canadian university ten years after setting a strategic plan, explores the interplay between instructors' concepts of teaching and use of technology, and searches for the best solutions to help them use technology more effectively. Results showed that…

  17. Indirect composite restorations luted with two different procedures: A ten years follow up clinical trial

    PubMed Central

    Preti, Alessandro; Vano, Michele; Derchi, Giacomo; Mangani, Francesco; Cerutti, Antonio

    2015-01-01

    Objectives: The aim of this clinical trial was to evaluate posterior indirect composite resin restoration ten years after placement luted with two different procedures. Study Design: In 23 patients 22 inlays/onlays (Group A) were luted using a dual-cured resin composite cement and 26 inlays/onlays (Group B) were luted using a light cured resin composite for a total of 48 Class I and Class II indirect composite resin inlays and onlays. The restorations were evaluated at 2 time points: 1) one week after placement (baseline evaluation) and 2) ten years after placement using the modified USPHS criteria. The Mann-Whitney and the Wilcoxon tests were used to examine the difference between the results of the baseline and 10 years evaluation for each criteria. Results: Numerical but not statistically significant differences were noted on any of the recorded clinical parameters (p>0.05) between the inlay/onlays of Group A and Group B. 91% and 94 % of Group A and B respectively were rated as clinically acceptable in all the evaluated criteria ten years after clinical function. Conclusions: Within the limits of the study the results showed after ten years of function a comparable clinical performance of indirect composite resin inlays/onlays placed with a light cure or dual cure luting procedures. Key words:Light curing composite, dual curing composite, indirect composite restoration, inlays/onlays, clinical trial. PMID:25810842

  18. Ten Years of GLAPHI Method Developing Scientific Research Abilities

    NASA Astrophysics Data System (ADS)

    Vega-Carrillo, Hector R.

    2006-12-01

    During the past ten years we had applied our method, GLAPHI, to teach how to do scientific research. The method has been applied from freshman students up to PhD professionals. The method is based in the search and analysis of scientific literature, the scientific question or problem, the approach of hypothesis and objetive, the estimation of the project cost and the timetable. It also includes statistics for research, author rights, ethics in research, publication of scientific papers, writting scientific reports and meeting presentations. In this work success and fails of GLAPHI methods will be discussed. Work partially supported by CONACyT (Mexico) under contract: SEP-2004-C01-46893

  19. Past ten years of noise control in the electric utilities

    SciTech Connect

    Teplitzky, A.M.

    1982-01-01

    During the past ten years, electric utility industry noise abatement activities have focused on quantifying noise emissons from proposed facilities and on abating noise from new facilities. Several studies have been undertaken in order to achieve these goals by the following electric utility organizations: The Edison Electric Institute (EEI), the principal association of investor owned American utilities; Electric Power Research Institute (EPRI), an organization founded by American electric utilities to develop and manage a technology program for improving electric power production, distribution and utilization; and the Empire State Electric Energy Research Corporation (ESEERCO), a research organization sponsored by the investor owned utilities in New York State. Presented in this paper are summaries of several studies sponsored by electric utility industry groups that have contributed to increasing the available information on electric utility noise emissions and the abatement of those emissions.

  20. Ten years of progress in the Superfund Program

    SciTech Connect

    Clay, D.R. )

    1991-02-01

    Superfund celebrated its tenth anniversary in December 1990. The Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) - popularly known as Superfund - was passed into law in December 1980 in the wake of such incidents as Love Canal and the Valley of the Drums. The program was designed to clean up uncontrolled hazardous waste sites and, during the past ten years, thousands of actions have been taken to protect human health and the environment from the hazards posed by those sites. EPA believes that goal is best met by its strategy: make sites safer - control immediate threats; enforce aggressively; make sites cleaner - worst problems at worst sites first; bring new technology to bear on the problem.

  1. Ten years of replantation surgery at the Department of Plastic Surgery, Charles University Hospital, Prague.

    PubMed

    Kletenský, J; Nejedlý, A; Pros, Z; Svoboda, S; Tvrdek, M

    1994-01-01

    The authors present results of the ten years replantation surgery centre at the department of plastic surgery in Prague. The presented series of patients includes 393 persons operated on because of amputation or ischaemic injury to the region of the upper extremity. The number of replantations and revascularisations in the individual years is analysed, as well as the age of the patients, type of injury, mechanism of injury and operation results. PMID:7618394

  2. Ural-Tweed Bighorn Sheep Wildlife Mitigation Project, 1984-1990 Final Report.

    SciTech Connect

    Young, Lewis R.; Yde, Chris A.

    1990-06-01

    The results of habitat improvement project activities accomplished under contract No.84-38 for bighorn sheep mitigation along Koocanusa Reservoir from September 1, 1984, through June 30, 1990, are reported here. Habitat treatments were applied to ten areas and covered 1100 acres. Treatments used were prescribed fire, slashing combined with prescribed fire, and fertilization. Several variations in season or intensity were used within the slashing and prescribed fire treatments. This project was coordinated with and complemented concurrent Kootenai National Forest habitat improvement activities.

  3. Ten Years of Real-Time Earthquake Loss Alerts

    NASA Astrophysics Data System (ADS)

    Wyss, M.

    2013-12-01

    The priorities of the most important parameters of an earthquake disaster are: Number of fatalities, number of injured, mean damage as a function of settlement, expected intensity of shaking at critical facilities. The requirements to calculate these parameters in real time are: 1) Availability of reliable earthquake source parameters within minutes. 2) Capability of calculating expected intensities of strong ground shaking. 3) Data sets on population distribution and conditions of building stock as a function of settlements. 4) Data on locations of critical facilities. 5) Verified methods of calculating damage and losses. 6) Personnel available on a 24/7 basis to perform and review these calculations. There are three services available that distribute information about the likely consequences of earthquakes within about half an hour of the event. Two of these calculate losses, one gives only general information. Although, much progress has been made during the last ten years improving the data sets and the calculating methods, much remains to be done. The data sets are only first order approximations and the methods bare refinement. Nevertheless, the quantitative loss estimates after damaging earthquakes in real time are generally correct in the sense that they allow distinguishing disastrous from inconsequential events.

  4. Chern-Simons gauge theory: Ten years after

    SciTech Connect

    Labastida, J. M. F.

    1999-07-13

    A brief review on the progress made in the study of Chern-Simons gauge theory since its relation to knot theory was discovered ten years ago is presented. Emphasis is made on the analysis of the perturbative study of the theory and its connection to the theory of Vassiliev invariants. It is described how the study of the quantum field theory for three different gauge fixings leads to three different representations for Vassiliev invariants. Two of these gauge fixings lead to well known representations: the covariant Landau gauge corresponds to the configuration space integrals while the non-covariant light-cone gauge to the Kontsevich integral. The progress made in the analysis of the third gauge fixing, the non-covariant temporal gauge, is described in detail. In this case one obtains combinatorial expressions, instead of integral ones, for Vassiliev invariants. The approach based on this last gauge fixing seems very promising to obtain a full combinatorial formula. We collect the combinatorial expressions for all the Vassiliev invariants up to order four which have been obtained in this approach.

  5. EU orphan regulation--ten years of application.

    PubMed

    Michaux, Geneviève

    2010-01-01

    In April 2000, European Regulation (EC) No 141/2000 on Orphan Medicinal Products, which, following the U.S. example, had been adopted to boost the research, development, and marketing of medicinal products for rare diseases, became effective. Ten years later, figures prove that, with an average of more than 70 orphan designations per year, the European orphan regulation is a success. To date, the key issue is no longer research and development but effective market access. Less than 10% of the orphan designated products are approved for marketing and even less products are actually placed on the European national markets due to pricing and reimbursement obstacles. The article examines the European orphan regime, focusing on its two cornerstones--orphan designation and exclusivity--and highlighting the concepts that are still unclear and the issues that have not yet been addressed. The European Orphan Regulation has been proved to work well, but it would be even more successful if orphan designation was easier and orphan incentives were more attractive. The article concludes on the changes to be made to the European orphan legal regime that would encourage even more the research and development of orphan products. PMID:24479246

  6. A Ten Year Record of Space Based Lightning Measurements

    NASA Astrophysics Data System (ADS)

    Conover, H.; Hardin, D. M.; Goodman, M.; Blakeslee, R.; Graves, S.; Jones, S.; Harrison, S.; Drewry, M.; Nair, M.

    2009-12-01

    The Lightning Imaging Sensor (LIS) is a space based instrument used to detect the distribution and variability of total lightning (cloud-to-cloud, intracloud, and cloud-to-ground lightning) that occurs in the tropical regions of the globe. LIS was launched in November 1997 aboard NASA’s Tropical Rainfall Measuring Mission (TRMM). The LIS sensor contains a staring imager which is optimized to locate and detect lightning with storm-scale resolution of 3-6 km (3 at nadir, 6 at limb) over a large region (550-550 km) of the Earth's surface. The field of view (FOV) is sufficient to observe a point on the Earth or a cloud for 80 seconds, adequate to estimate the flashing rate of many storms. The instrument records the time of occurrence of a lightning event, measures the radiant energy, and estimates the location. The excellent performance of LIS has lead to numerous scientific discoveries such as: The global lightning flash rate is on the order of 40 flashes per second as compared to the commonly accepted value of 100, an estimate that dates back to 1925. Seventy percent of all lightning activity occurs in the tropics, with the global distribution dominated by the summertime lightning activity over the N. Hemisphere land masses. A new understanding on the interplay among the intensification of updraft, lightning bursts, and the onset of severe weather lead to establishment of a validation campaign that further explored relationships between lightning and severe weather. Findings to date indicate that high flash rate storms have a high probability of becoming severe. A ten year global lightning data archive has been developed from the Lightning Imaging Sensor. This archive is maintained at the Global Hydrology Resource Center (GHRC) in Huntsville Alabama, one of NASA’s Earth science data centers, managed by the Information Technology and Systems Center of UAHuntsville. This is the most comprehensive global lightning data archive ever produced and is noteworthy for its

  7. Ten-Year Retrospective on the Pinatubo Eruption

    NASA Astrophysics Data System (ADS)

    Newhall, C. G.; Punongbayan, R. S.

    2001-12-01

    The 1991-92 eruption of Pinatubo Volcano, Philippines was a signal event in the annals of volcanology. For the first time, modern monitoring captured the pre-, syn-, and post-eruption signatures of a sulfur-rich, plinian, caldera-forming eruption. Approximately 5 km3 of magma was erupted, of which slightly more than half became pyroclastic flows, and the balance became tephra fall. Only a negligible percentage of the magma fed early and final-stage lava domes. Ten years later, more than half of the debris on Pinatubo's slopes has been washed by lahars and sediment-laden streamflow into the surrounding lowlands, adding to Pinatubo's broad alluvial fans. Other papers in this symposium will give details of the magma, volatiles, eruption dynamics, lahars, atmospheric effects, and other features of the eruption. Here, we reflect on just four lessons. First, the magma of a long-plugged volcano may be saturated with respect to water and other volatiles even at depth, and, when disturbed by regional strain or other change, can rise quickly. Second, up until just before the eruption itself, only the geologic record foretold of how large it would be. Third, because few observatories will monitor dormant volcanoes and few residents will heed long-range warnings, public safety will hinge on a short, urgent campaign of warning and education. Videos, simple alert schemes, and a willingness of both scientists and public officials to move decisively despite uncertainty are essential to win cooperation from a skeptical public. Fourth, post-eruption hydrologic hazards can equal or exceed those of an eruption itself.

  8. Looking back at a US desalting forecast - ten years later

    SciTech Connect

    Rothermel, T.W.

    1982-01-01

    Forecasts made a decade ago of US desalting capacity by 1980 achieved mixed success when compared to the most recent Desalting Plants Inventory. Projections of national brackish water were right on the button. The forecast of new brackish capacity for 1965 to 1980 was 105 Mgd. The Inventory indicates that 106 Mgd was installed. Seawater desalting forecasts, however, were just as overly optimistic as the projected costs upon which they were based: 191 Mgd was forecasted for 1965 to 1980; only 10 Mgd actually went on-stream. Forecasts were also made of desalting waste-waters for reuse. The recent emergence of this desalting application was reflected in a forecast of 5 Mgd, which was still less than the 23 Mgd found in the Inventory. These forecasts were made with a dynamic simulation model of the water demand and supply situations in 100 subregions of the United States. This computerized model was built under the sponsorship of the US Department of the Interior to provide a basis for estimating the benefits of federally sponsored desalting research. The model also promises valuable planning insights for regulatory and research programs in broader water resources activities. The most recent Desalting Plants Inventory is certainly unfair to forecasters by systematically tracking actual installations of desalting capacity. This article compares data in the Inventory to forecasts developed over ten years ago. That work was sponsored by the former Office of Saline Water (OSW) and its successor, the Office of Water Research and Technology (OWRT). These forecasts were created from a simulation model of the national water situation. 5 references, 1 figure, 3 tables.

  9. Frequency of serial sexual homicide victimization in Virginia for a ten-year period.

    PubMed

    McNamara, James J; Morton, Robert J

    2004-05-01

    The frequency of serial sexual murder has been widely discussed, and estimates of the number of victims in the United States range from 500 to 6000 per year. This study attempted to quantify the number of serial sexual murder victims in Virginia for a ten-year period. Multiple sources of data were utilized, including Federal Bureau of Investigation (FBI) case files, FBI's Violent Criminal Apprehension Program (ViCAP) reports, Virginia State Police ViCAP reports, Virginia Homicide Investigators Association, and the Virginia Division of Forensic Science DNA database, to effectively cull out all the known serial sexual murder victims for the given time period. Review of these records revealed a total of 28 victims of serial sexual murder, compared with a total of 5183 murder victims for the same ten-year period. The frequency of serial sexual victimization was 0.5% of all homicides for the given period. These results highlight the unusual frequency of serial sexual murder. PMID:15171171

  10. Ten Years of Tamoxifen Reduces Breast Cancer Recurrences, Improves Survival

    Cancer.gov

    Taking adjuvant tamoxifen for 10 years after primary treatment leads to a greater reduction in breast cancer recurrences and deaths than taking the drug for only 5 years, according to the results of a large international clinical trial.

  11. Ten-Year Study of a Wilson's Disease Dysarthric.

    ERIC Educational Resources Information Center

    Day, Linda Susan; Parnell, Martha M.

    1987-01-01

    The 10-year longitudinal case study describes the history, speech therapy program, and treatment results for an adult male with Wilson's disease, a genetically based metabolic progressive neurological disorder which includes severe speech problems. (DB)

  12. Scientific achievements from ten years of lunar laser ranging

    NASA Technical Reports Server (NTRS)

    Mulholland, J. D.

    1980-01-01

    In the 10 years since lunar laser ranging became a reality the need to analyze the observations has motivated improvements in several aspects of the mathematical model of earth-moon dynamics. Application of the data to improved estimates of the physical parameters of the earth-moon system has yielded significant astronomical, selenophysical, geophysical, and cosmological results. The scientific impact, both in improved theories and in numerical applications, is surveyed. The underlying physics and major difficulties are discussed, as well as the scientific results.

  13. Black Mesa Community School: Ten Years Later. A Progress Report.

    ERIC Educational Resources Information Center

    Black Mesa Community School Board, Inc., Chinle, AZ.

    The Black Mesa Community School, serving elementary school children in an isolated district of the Arizona Navajo reservation, represents the first step in Indian self-determination for area Navajos. The school is the result of community efforts begun in 1972 with a petition to operate a full-time school program for grades K-4 at Kitsilee.…

  14. National Sea Grant College Program: The First Ten Years.

    ERIC Educational Resources Information Center

    Hull, E. W. Seabrook

    The National Sea Grant College Program sponsors efforts which encompass research applied to current problems, labor force development, and transfer of technology and knowledge to people who need it in a form they can use. Summarized in this report are Sea Grant's history, programs, and results during its first decade (1967-1976). Provided is an…

  15. Computing Trends in Small Liberal Arts Colleges: Ten Years Later.

    ERIC Educational Resources Information Center

    Smith, Peter

    Forty-one small liberal arts colleges were visited during the 1997-98 school year in order to talk to key information technology staff and to see computing facilities. A survey containing 15 factual and 10 open-ended questions was used to gather information. This paper presents findings in the following areas and comparison with results of a…

  16. Ten Years Later: Locating and Interviewing Children of Drug Abusers

    ERIC Educational Resources Information Center

    Haggerty, Kevin P.; Fleming, Charles B.; Catalano, Richard F.; Petrie, Renee S.; Rubin, Ronald J.; Grassley, Mary H.

    2008-01-01

    Longitudinal studies require high follow-up rates in order to maintain statistical power, reduce bias, and enhance the generalizability of results. This study reports on locating and survey completion for a 10-year follow-up of the Focus on Families project, an investigation of 130 families headed by parents who were enrolled in methadone…

  17. Ten-year study on acid precipitation nears conclusion

    SciTech Connect

    Olem, H. )

    1990-04-01

    Results from the National Acid Precipitation Assessment Program (NAPAP) are discussed. Final results are contained in 26 state of the science reports. Seven of the reports provide information on acid rain and aquatic ecosystems. They describe the current state of acidic surface waters, watershed processes affecting surface water chemistry, historical evidence for surface water acidification, methods for forecasting future changes, and the response of acidic surface water to liming. Six areas of the country were found to be of special interest: southwest Adirondacks, New England, forested areas of the mid-Atlantic highlands, the Atlantic coastal plain, the northern Florida highlands, parts of northeastern Wisconsin and the Upper Peninsula of Michigan. Environmental effects, mitigation efforts and possible legislation are briefly discussed.

  18. The Offense Patterns of Rural Delinquents: A Ten Year Assessment.

    ERIC Educational Resources Information Center

    Thilmony, Jeri J.; And Others

    Research on rural delinquency is far from prolific and tends to focus on non-trend comparisons with the urban sector (see, for example, Clinard, 1942 and Lentz, 1956). The purpose of this paper is to present the results of a trend study of rural delinquents (N=3,347 non-traffic cases) based on the 1965 through 1974 juvenile court records of nine…

  19. The Catholic School under Scrutiny: Ten Years of Research in Italy (1998-2008)

    ERIC Educational Resources Information Center

    Malizia, Guglielmo; Cicatelli, Sergio

    2011-01-01

    This book delineates the evolution of the Study Centre for Catholic Schools (CSSC) in its first ten years of existence since its foundation in 1998 by the Italian Bishops' Conference. The volume is divided into three main sections. The first outlines the context and the activity of the CSSC during ten years: the role, the functions, the tasks and…

  20. Ten years of experience from interactive ergonomics projects.

    PubMed

    Eklund, J; Karltun, J

    2012-01-01

    This paper highlights experiences from ergonomics projects, applying an interactive research approach. The aim of this paper is to summarise experiences from seven interactive ergonomics projects with the aim to improve ergonomics and organizational performance jointly. Results from these seven projects were analysed with a model for assessing sustainable change, including the factors active ownership, professional management, competent project leadership, and involved participants. All factors were found giving support to impact and sustainability of the change projects. However, the role of the researcher is difficult and demanding. PMID:22317471

  1. Ten Years in the Making: AUSM-Family

    NASA Technical Reports Server (NTRS)

    Liou, Meng-Sing

    2001-01-01

    We begin by describing the motivations that gave birth to the original AUSM scheme and then focus on the ingredients that has spurred its growth and acceptance by the world of computational fluid dynamics. As it has played out more in the field, weaknesses have also surfaced. Hence, nutrients and supplements are prescribed to help it grow and stay strong and robust. In this paper, we will describe the saga of efforts owing to researchers who have contributed to building up the AUSM-family for the CFD community. It is hoped that a healthy scheme will contribute to the accurate and robust solution of problems encountered in a wide range of disciplines. We analyze numerical mass fluxes with an emphasis on their capability for accurately capturing shock and contact discontinuities. We will present a new scheme for the pressure flux, along with results for a host of test problems.

  2. [Ten years of nucleic acid testing: lessons and prospects].

    PubMed

    Morel, P

    2011-04-01

    Nucleic acid testing has been routinely performed in all blood donations in France since July 1st 2001. This is the story of a controversial decision. "The unacceptable HIV risk" in the context of the early 2000s influenced the decision. The results achieved over these past 10 years are analyzed given the expected progress of this new screening tool for infectious agents in transfusion. They confirm the relevance of models used by experts in 2000. Out of 22.3 million donations over the period (2001-2009), 22 donations have been rejected because of nucleic acid testing positive for hepatitis C virus (n=11) and human immunodeficiency virus (n=11). Nucleic acid testing has contributed to improve the functioning of the transfusion chain activities in order to ensure the availability of blood products. In terms of reactivity against emerging infectious agents, its role in the West Nile virus (WNV) outbreak is exemplary, but it did not play a similar role in crises of the same order. ALT determination has been stopped thanks to nucleic acid testing. The risk of contamination of the method by amplification products has been confirmed and caution is still required. Nucleic acid testing is being maintained and reached a new milestone in 2010 with the implementation of a full automated system, meanwhile pool screening was given up and hepatitis B virus screening became widespread. Nucleic acid tests will probably be revised when all blood products are pathogen-inactivated. PMID:21397544

  3. Ten-Year Experience of Remote Medical Education in Asia

    PubMed Central

    Kudo, Kuriko; Antoku, Yasuaki; Hu, Min; Okamura, Koji; Nakashima, Naoki

    2014-01-01

    Abstract Background: Moving images are often essential in medical education, to learn new procedures and advanced skills, but, in the past, high-quality movie transmission was technically much more challenging than transmitting still pictures because of technological limitations and cost. Materials and Methods: We established a new system, taking advantage of two advanced technologies, the digital video transport system (DVTS) and the research and education network (REN), which enabled satisfactory telemedicine on a routine basis. Results: Between 2003 and 2013, we organized 360 programs connecting 221 hospitals or facilities in 34 countries in Asia and beyond. The two main areas were endoscopy and surgery, with 113 (31%) and 106 (29%) events, respectively. Teleconferences made up 76% of the total events, with the remaining 24% being live demonstrations. Multiple connections were more popular (63%) than one-to-one connections (37%). With continuous technological development, new high-definition H.323 and Vidyo® (Hackensack, NJ) systems were used in 47% and 39% of events in 2011 and 2012, respectively. The evaluation by questionnaires was favorable on image and sound quality as well as programs. Conclusions: Remote medical education with moving images was well accepted in Asia with changing needs and developing technologies. PMID:25272006

  4. Ten years on: generating innovative responses to avian influenza.

    PubMed

    Forster, Paul

    2014-01-01

    Since 2006, the number of recorded H5N1 avian influenza outbreaks has declined globally, but at mid-2012 the disease was enzootic in six countries in Asia and Africa, and sporadic outbreaks continue over a wide area. It is now accepted that it will take decades to eliminate the H5N1 virus in poultry and 'unconventional' response approaches have been called for. Drawing on increased understandings of the epizoosis over the last 10 years, this paper investigates what conditions are required if such innovative approaches are to be generated. It argues that addressing the spread and persistence of avian influenza is primarily a political matter, and if approaches appropriate for enzooticity are to be devised, the social, political, and economic dynamics of the disease and responses to it need to be identified and prioritised. A dominant response strategy focused on outbreak events, containment and eradication has obscured these important dynamics. If innovative 'unconventional' responses are to be generated, a wider range of perspectives and expertise needs to be engaged. This will result in political processes of negotiation, which the technically led, development-orientated institutions directing and funding the global response are ill-equipped to facilitate. PMID:24337506

  5. CFIRP: What we learned in the first ten years

    USGS Publications Warehouse

    Chambers, C.L.; McComb, W.C.; Tappeiner, J. C., II; Kellogg, L.D.; Johnson, R.L.; Spycher, G.

    1999-01-01

    In response to public dissatisfaction with forest management methods, we initiated the College of Forestry Integrated Research Project (CFIRP) to test alternative silvicultural systems in Douglas-fir (Pseudotsuga menziesii stands in western Oregon. We compared costs and biological and human responses among a control and three replicated silvicultural alternatives to clearcutting that retained structural features found in old Douglas-fir forests. Treatments were applied within 8- to 15-ha stands and attempted to mimic crown fires (modified clearcut), windthrow (green tree retention), and small-scale impacts such as root rot diseases (small patch group selection). We also compared costs in three unreplicated treatments (large patch group selection, wedge cut, and strip cut). Each treatment included differences in the pattern of retained dead trees (snags), as either scattered individuals or as clumps. Good communication among researchers and managers, a long-term commitment to the project, and careful documentation of research sites and data are important to the success of long-term silvicultural research projects. To date, over 30 publications have resulted from the project.

  6. Lessons from ten years of crystallization experiments at the SGC

    PubMed Central

    Ng, Jia Tsing; Dekker, Carien; Reardon, Paul; von Delft, Frank

    2016-01-01

    Although protein crystallization is generally considered more art than science and remains significantly trial-and-error, large-scale data sets hold the promise of providing general learning. Observations are presented here from retrospective analyses of the strategies actively deployed for the extensive crystallization experiments at the Oxford site of the Structural Genomics Consortium (SGC), where comprehensive annotations by SGC scientists were recorded on a customized database infrastructure. The results point to the importance of using redundancy in crystallizing conditions, specifically by varying the mixing ratios of protein sample and precipitant, as well as incubation temperatures. No meaningful difference in performance could be identified between the four most widely used sparse-matrix screens, judged by the yield of crystals leading to deposited structures; this suggests that in general any comparison of screens will be meaningless without extensive cross-testing. Where protein sample is limiting, exploring more conditions has a higher likelihood of being informative by yielding hits than does redundancy of either mixing ratio or temperature. Finally, on the logistical question of how long experiments should be stored, 98% of all crystals that led to deposited structures appeared within 30 days. Overall, these analyses serve as practical guidelines for the design of initial screening experiments for new crystallization targets. PMID:26894670

  7. Fish on Prozac (and Zoloft): ten years later.

    PubMed

    Brooks, Bryan W

    2014-06-01

    A decade has now passed since our research group initially reported several adverse effects of fluoxetine to aquatic organisms commonly employed for developing environmental quality criteria, evaluating whole effluent toxicity, and monitoring ambient toxicity of surface waters and sediments. Our subsequent observation of fluoxetine, sertraline and their active metabolites (norfluoxetine and desmethylsertraline, respectively) accumulating in muscle, liver and brain tissues of three different fish species from an effluent-dominated stream was termed "Fish on Prozac." Here I briefly review some scientific lessons learned from our study of antidepressants and the environment, including opportunities for research, management, environmental education and public outreach. Intrinsic chemical properties of antidepressants and other pharmaceuticals have afforded research in areas ranging from analytical chemistry and comparative pharmacology, to influences of ionization, chirality and adverse outcome pathways on hazard and risk assessment, and further promises to support sustainable molecular design of less hazardous chemicals. Using probabilistic hazard assessment and fish plasma modeling approaches, selective serotonin reuptake inhibitors and tricyclic antidepressants are predicted to result in therapeutic hazard to fish (internal fish plasma level equaling mammalian therapeutic dose) when exposed to water (inhalational) at or below 1μg/L, a common trigger value for environmental assessments. Though many questions remain unanswered, studies of antidepressants in urbanizing aquatic systems have provided, and will continue to develop, an advanced understanding of environmental hazards and risks from pharmaceuticals and other contaminants. PMID:24503458

  8. The Huygens Doppler Wind Experiment: Ten Years Ago

    NASA Astrophysics Data System (ADS)

    Bird, Michael; Dutta-Roy, Robin; Dzierma, Yvonne; Atkinson, David; Allison, Michael; Asmar, Sami; Folkner, William; Preston, Robert; Plettemeier, Dirk; Tyler, Len; Edenhofer, Peter

    2015-04-01

    The Huygens Doppler Wind Experiment (DWE) achieved its primary scientific goal: the derivation of Titan's vertical wind profile from the start of Probe descent to the surface. The carrier frequency of the ultra-stable Huygens radio signal at 2040 MHz was recorded using special narrow-band receivers at two large radio telescopes on Earth: the Green Bank Telescope in West Virginia and the Parkes Radio Telescope in Australia. Huygens drifted predominantly eastward during the parachute descent, providing the first in situ confirmation of Titan's prograde super-rotational zonal winds. A region of surprisingly weak wind with associated strong vertical shear reversal was discovered within the range of altitudes from 65 to 100 km. Below this level, the zonal wind subsided monotonically from 35 m/s to about 7 km, at which point it reversed direction. The vertical profile of the near-surface winds implies the existence of a planetary boundary layer. Recent results on Titan atmospheric circulation within the context of the DWE will be reviewed.

  9. Ten year neurocognitive trajectories in first-episode psychosis

    PubMed Central

    Barder, Helene E.; Sundet, Kjetil; Rund, Bjørn R.; Evensen, Julie; Haahr, Ulrik; Ten Velden Hegelstad, Wenche; Joa, Inge; Johannessen, Jan O.; Langeveld, Johannes; Larsen, Tor K.; Melle, Ingrid; Opjordsmoen, Stein; Røssberg, Jan I.; Simonsen, Erik; Vaglum, Per; McGlashan, Thomas; Friis, Svein

    2013-01-01

    Objective: Neurocognitive impairment is commonly reported at onset of psychotic disorders. However, the long-term neurocognitive course remains largely uninvestigated in first episode psychosis (FEP) and the relationship to clinically significant subgroups even more so. We report 10 year longitudinal neurocognitive development in a sample of FEP patients, and explore whether the trajectories of cognitive course are related to presence of relapse to psychosis, especially within the first year, with a focus on the course of verbal memory. Method: Forty-three FEP subjects (51% male, 28 ± 9 years) were followed-up neurocognitively over five assessments spanning 10 years. The test battery was divided into four neurocognitive indices; Executive Function, Verbal Learning, Motor Speed, and Verbal Fluency. The sample was grouped into those relapsing or not within the first, second and fifth year. Results: The four neurocognitive indices showed overall stability over the 10 year period. Significant relapse by index interactions were found for all indices except Executive Function. Follow-up analyses identified a larger significant decrease over time for the encoding measure within Verbal Memory for patients with psychotic relapse in the first year [F(4, 38) = 5.8, p = 0.001, η2 = 0.40]. Conclusions: Main findings are long-term stability in neurocognitive functioning in FEP patients, with the exception of verbal memory in patients with psychotic relapse or non-remission early in the course of illness. We conclude that worsening of specific parts of cognitive function may be expected for patients with on-going psychosis, but that the majority of patients do not show significant change in cognitive performance during the first 10 years after being diagnosed. PMID:24109449

  10. Alcohol Intoxication in Pediatric Age: Ten-year Retrospective Study

    PubMed Central

    Bitunjac, Kristina; Saraga, Marijan

    2009-01-01

    Aim To examine the changes in the number of children younger than 18 who were hospitalized due to alcohol intoxication at the Department of Pediatrics, University Hospital of Split, from November 1, 1997 to October 31, 2007. Methods Data on children hospitalized due to intoxication were retrieved from hospital medical records. Children were classified into 4 age groups: 0-5, 6-9, 10-13, and 14-18 years, and their sex and type of intoxication were recorded. For children with alcohol intoxication, data on time of intoxication, reason for drinking, presence of injuries or suspected suicide attempts, and possible presence of other drugs in the organism were collected. Results Out of 29 506 hospitalized children, 594 were hospitalized due to intoxications. Out of these, 239 (40.2%) were hospitalized due to intoxication by alcohol. More boys than girls were hospitalized (71.1%). The proportion of alcohol intoxication cases among all types of intoxication cases increased from 16.7% in 1997/98 to 66.3% in 2006/07. The proportion of patients hospitalized due to alcohol intoxication increased from 0.3% of all hospitalized children in the first year to 1.7% in the last year of the study (P = 0.015, z test for comparison of two proportions). Eighty two per cent of cases of alcohol intoxication were in the 14-18 age-group. The number of alcohol intoxication cases increased among girls from 1 case (6.3% of all intoxication cases among girls) in 1997/98 to 15 cases (45.5%) in 2006/07, while among boys it increased from 6 cases (23.1% of all intoxicated boys) in 1997/98 to 44 cases (78.6%) in 2006/07. Children usually drank outside their homes (79.4%) and mostly on weekends and holidays (73.2%). Conclusion The alarming increase in the number of hospitalizations due to alcohol intoxication in children, especially among girls and in the adolescent age group, represents a serious problem, which requires further attention and research. PMID:19399948

  11. Ten-year change in plasma amyloid β levels and late-life cognitive decline

    PubMed Central

    Okereke, Olivia I.; Xia, Weiming; Selkoe, Dennis J.; Grodstein, Francine

    2009-01-01

    Background Plasma levels of the amyloid β-peptides (Aβ) are potential biomarkers of early cognitive impairment and decline, and of Alzheimer disease (AD) risk. Objective To relate mid-life plasma Aβ measures, and ten-year change in plasma Aβ since mid-life, to later-life cognitive decline. Design, setting, participants Plasma Aβ-40 and Aβ-42 levels were measured in 481 Nurses’ Health Study participants in late mid-life (mean age=63.6 years) and again 10 years later (mean age=74.6 years). Cognitive testing also began 10 years after the initial blood draw. Participants completed three repeated telephone-based assessments (average span=4.1 years). Multivariable linear mixed effects models were used to estimate relations of mid-life plasma Aβ-40:Aβ-42 ratios and Aβ-42 levels to later-life cognitive decline, and to relate ten-year change in Aβ-40:Aβ-42 and Aβ-42 to cognitive decline. Main Outcome Measures The primary outcomes were: the Telephone Interview for Cognitive Status (TICS); a global score averaging all tests (TICS, immediate and delayed verbal recall, category fluency, and attention); and a verbal memory score averaging four tests of verbal recall. Results Higher mid-life plasma Aβ-40:Aβ-42 ratio was associated with worse later-life decline on the global score (p-trend=0.04). Furthermore, an increase in Aβ-40:Aβ-42 since mid-life predicted greater decline on the global score (p-trend=0.03) and the TICS (p-trend=0.02). There was no association between mid-life plasma Aβ-42 levels alone – or change in Aβ-42 since mid-life – and cognitive decline. Conclusions In this large community-dwelling sample, higher plasma Aβ-40:Aβ-42 ratios in late mid-life, and increases in Aβ-40:Aβ-42 ten years later, were significantly associated with greater decline in global cognition at late-life. PMID:19822780

  12. Cause-Specific Mortality in HIV-Positive Patients Who Survived Ten Years after Starting Antiretroviral Therapy

    PubMed Central

    May, Margaret T.; Vehreschild, Janne; Obel, Niels; Gill, Michael John; Crane, Heidi; Boesecke, Christoph; Samji, Hasina; Grabar, Sophie; Cazanave, Charles; Cavassini, Matthias; Shepherd, Leah; d’Arminio Monforte, Antonella; Smit, Colette; Saag, Michael; Lampe, Fiona; Hernando, Vicky; Montero, Marta; Zangerle, Robert; Justice, Amy C.; Sterling, Timothy; Miro, Jose; Ingle, Suzanne; Sterne, Jonathan A. C.

    2016-01-01

    Objectives To estimate mortality rates and prognostic factors in HIV-positive patients who started combination antiretroviral therapy between 1996–1999 and survived for more than ten years. Methods We used data from 18 European and North American HIV cohort studies contributing to the Antiretroviral Therapy Cohort Collaboration. We followed up patients from ten years after start of combination antiretroviral therapy. We estimated overall and cause-specific mortality rate ratios for age, sex, transmission through injection drug use, AIDS, CD4 count and HIV-1 RNA. Results During 50,593 person years 656/13,011 (5%) patients died. Older age, male sex, injecting drug use transmission, AIDS, and low CD4 count and detectable viral replication ten years after starting combination antiretroviral therapy were associated with higher subsequent mortality. CD4 count at ART start did not predict mortality in models adjusted for patient characteristics ten years after start of antiretroviral therapy. The most frequent causes of death (among 340 classified) were non-AIDS cancer, AIDS, cardiovascular, and liver-related disease. Older age was strongly associated with cardiovascular mortality, injecting drug use transmission with non-AIDS infection and liver-related mortality, and low CD4 and detectable viral replication ten years after starting antiretroviral therapy with AIDS mortality. Five-year mortality risk was <5% in 60% of all patients, and in 30% of those aged over 60 years. Conclusions Viral replication, lower CD4 count, prior AIDS, and transmission via injecting drug use continue to predict higher all-cause and AIDS-related mortality in patients treated with combination antiretroviral therapy for over a decade. Deaths from AIDS and non-AIDS infection are less frequent than deaths from other non-AIDS causes. PMID:27525413

  13. Health evaluation of the 2nd International "Quit and Win" Antinicotine Campaign participants ten years later.

    PubMed

    Kowalska, Alina; Stelmach, Włodzimierz; Krakowiak, Jan; Rzeźnicki, Adam; Pikala, Małgorzata; Dziankowska-Zaborszczyk, Elzbieta; Drygas, Wojciech

    2008-01-01

    Smoking is one of the most often noticed types of negative behaviour among the Poles. In the work, the results of the health evaluation are presented of the participants of the 'Quit and Win' competition ten years after making a decision to refrain from smoking, also the dependency between this evaluation and behaviour connected with smoking among the people living in big cities and small towns and villages was analysed. Among the 648 respondents, majority, which is 302 people (46.6%) evaluated their health as good, 236 (36.4%) as average, and 76 of the questioned (11.7%) as very good, 29 people (4.5%) as bad, and 5 of the questioned (0.8%) as very bad. The respondents most often evaluated negatively their health in the group of the still smoking living in the big cities, and the least often in the group of the non-smokers living in small towns and villages. PMID:19189564

  14. Introduction to "Tsunami Science: Ten Years after the 2004 Indian Ocean Tsunami. Volume II."

    NASA Astrophysics Data System (ADS)

    Rabinovich, Alexander B.; Geist, Eric L.; Fritz, Hermann M.; Borrero, Jose C.

    2015-12-01

    Twenty papers on the study of tsunamis and respective tsunamigenic earthquakes are included in Volume II of the PAGEOPH topical issue "Tsunami Science: Ten Years after the 2004 Indian Ocean Tsunami". The papers presented in this second of two special volumes of Pure and Applied Geophysics reflect the state of tsunami science during this time, including five papers devoted to new findings specifically in the Indian Ocean. Two papers compile results from global observations and eight papers cover Pacific Ocean studies, focusing mainly on the 2011 Tohoku earthquake and tsunami. Remaining papers in this volume describe studies in the Atlantic Ocean and Mediterranean Sea and tsunami source studies. Overall, the volume not only addresses the pivotal 2004 Indian Ocean and 2011 Tohoku tsunamis, but also examines the tsunami hazard posed to other critical coasts in the world.

  15. Evaluation of Nutritional Biochemical Parameters in Haemodialysis Patients over a Ten-year Period

    PubMed Central

    Alfonso, AIQ; Castillo, RF; Jimenez, FJ Gomez; Negrillo, AM Nuñez

    2015-01-01

    ABSTRACT Aim: Protein-energy malnutrition as well as systemic inflammation and metabolic disorders are common in patients with chronic kidney failure who require renal replacement therapy (haemodialysis). Such malnutrition is a factor that significantly contributes to their morbidity and mortality. This study evaluated the nutritional status of haemodialysis patients by assessing biochemical and anthropometric parameters in order to determine whether these patients suffered disorders reflecting nutritional deterioration directly related to time on haemodialysis. Subjects and Method: This research comprised 90 patients of both genders with chronic kidney failure, who regularly received haemodialysis at our unit over a period of ten years. The patients' blood was tested quarterly for plasma albumin, total cholesterol and total proteins, and tested monthly for transferrin. The patients' weight, height and body mass index (BMI) were monitored. Body mass index was calculated using the formula: weight (kg)/height (m2) and classified in one of the following categories defined in the World Health Organization (WHO) Global Database on Body Mass Index: (i) underweight [BMI < 18.50], (ii) normal [BMI 18.50 – 24.99], (iii) overweight [BMI 25 – 29.99], (iv) obese [BMI ≥ 30]. Results: In the ten-year period of the study, the patients experienced a substantial decline in their biochemical parameters. Nevertheless, their BMI did not show any significant changes despite the patients' state of malnutrition. Conclusions: The prevalence of malnutrition in haemodialysis patients was evident. Nevertheless, the BMI of the subjects did not correspond to the biochemical parameters measured. Consequently, the results showed that the nutritional deterioration of these patients was mainly reflected in their biochemical parameters rather than in their anthropometric measurements. PMID:26426172

  16. Five and Ten Year Follow-up on Intradiscal Ozone Injection for Disc Herniation

    PubMed Central

    Buric, Josip; Rigobello, Luca; Hooper, David

    2014-01-01

    Background Disc herniation is the most common cause for spinal surgery and many clinicians employ epidural steroid injections with limited success. Intradiscal injection of ozone gas has been used as an alternative to epidural steroids and surgical discectomy. Early results are positive but long-term data are limited. Methods One hundred and eight patients with confirmed contiguous disc herniation were treated with intradiscal injection of ozone in 2002-2003. One-hundred seven patients were available for telephone follow-up at 5 years. Sixty patients were available for a similar telephone follow-up at ten years. Patients were asked to describe their clinical outcome since the injection. Surgical events were documented. MRI images were reviewed to assess the reduction in disc herniation at six months. Results MRI films demonstrated a consistent reduction in the size of the disc herniation. Seventy-nine percent of patients had a reduction in herniation volume and the average reduction was 56%. There were 19 patients that ultimately had surgery and 12 of them occurred in the first six months after injection. One of these 12 was due to surgery at another level. Two surgeries involved an interspinous spacer indicated by stenosis or DDD. All other surgeries were discectomies. Of the patients that avoided surgery 82% were improved at 5 years and 88% were improved at 10 years. Other than subsequent surgeries, no spine-related complications were experienced. Conclusions/Level of Evidence We conclude that ozone is safe and effective in approximately 75% of patients with disc herniation and the benefit is maintained through ten years. This is a retrospective review and randomized trials are needed. Clinical Relevance Intradiscal ozone injection may enable patients to address their pain without multiple epidural injections and surgery. The benefit of ozone is durable and does not preclude future surgical options. The risk reward profile for this treatment is favorable. PMID

  17. Effectiveness of different methods to control legionella in the water supply: ten-year experience in an Italian university hospital.

    PubMed

    Marchesi, I; Marchegiano, P; Bargellini, A; Cencetti, S; Frezza, G; Miselli, M; Borella, P

    2011-01-01

    We report our ten-year experience of hyperchlorination, thermal shock, chlorine dioxide, monochloramine, boilers and point-of-use filters for controlling legionella contamination in a hospital hot water distribution system. Shock disinfections were associated with a return to pre-treatment contamination levels within one or two months. We found that chlorine dioxide successfully maintained levels at <100 cfu/L, whilst preliminary experiments gave satisfactory results with monochloramine. No contamination was observed applying point-of-use filters and electric boilers at temperatures of >58°C and no cases of nosocomial legionellosis were detected in the ten-year observation period. Our performance ranking in reducing legionella contamination was filter, boiler, chlorine dioxide, hyperchlorination and thermal shock. Chlorine dioxide was the least expensive procedure followed by thermal shock, hyperchlorination, boiler and filter. We suggest adopting chlorine dioxide and electric boilers in parallel. PMID:21131100

  18. Ten-Year Comparison of Oxidized Zirconium and Cobalt-Chromium Femoral Components in Total Knee Arthroplasty

    PubMed Central

    Roe, Justin; Vioreanu, Mihai; Salmon, Lucy; Waller, Alison; Pinczewski, Leo

    2016-01-01

    Objective: The purpose of this study was to determine if oxidized zirconium femoral components had better outcomes than cobalt-chromium in vivo at medium and long term and if the use of oxidized zirconium components had clinical adverse effects. Methods: Forty consecutive patients (eighty knees) underwent simultaneous bilateral cruciate-retaining total knee arthroplasty for primary osteoarthritis from January 2002 to December 2003. For each patient, the knees were randomized to receive the oxidized zirconium femoral component, with the contralateral knee receiving the cobalt-chromium component. Outcome measures included the Western Ontario and McMaster Universities Osteoarthritis Index, Knee Injury and Osteoarthritis Outcome Score, Knee Society score, and British Orthopaedic Association patient satisfaction scale. Radiographic outcomes include the Knee Society total knee arthroplasty roentgenographic evaluation and scoring system and measurement of radiographic wear. Patients and assessors were blinded to the treatment groups and results. Results: There were no significant differences in clinical, subjective, and radiographic outcomes between the two implants at ten years postoperatively. Ten years following surgery, 36% of the patients preferred the cobalt-chromium knee compared with 11% who preferred the oxidized zirconium knee (p = 0.02) and 53% had no preference. Conclusions: Ten-year outcomes after total knee arthroplasty with oxidized zirconium and cobalt-chromium femoral components showed no significant differences in clinical, subjective, and radiographic outcomes. Patients had no preference or preferred the cobalt chromium prosthesis to the oxidized zirconium prosthesis. There were no adverse effects associated with the use of oxidized zirconium femoral implants.

  19. Aboveground production does not increase after ten years of elevated CO2 in the Mojave Desert

    NASA Astrophysics Data System (ADS)

    Newingham, B. A.; Vanier, C. H.; Charlet, D.; Zitzer, S. F.; Smith, S. D.

    2011-12-01

    Elevated atmospheric CO2 ([CO2]) is assumed to increase primary production, particularly in desert systems through stimulatory effects on plant water-use efficiency. We examined the effects of elevated [CO2] at the Nevada Desert FACE (Free-air CO2 Enrichment) Facility (NDFF) in an intact Mojave Desert ecosystem. At the NDFF, ambient and elevated [CO2] levels were 360 and 550 μmol mol-1 [CO2], respectively. CO2 treatments were applied continuously from 1997-2007 in intact plots 25 m in diameter. While other studies focused on soil and root responses to elevated [CO2], our study focused on aboveground production of annuals and perennial plants. In 1997, diameters and heights of all perennial individuals were recorded and mapped. In 2007, diameters and heights were re-measured and aboveground biomass was harvested for every mapped perennial individual. Harvest data were used to construct regressions for twenty perennial species to predict starting biomass based on diameters and heights. Annual plants were harvested yearly at peak biomass from permanent transects. We found no significant effect of elevated [CO2] on total perennial plant biomass or cover at the end of the experiment. Regardless of [CO2] treatment, perennial cover increased while total biomass did not change over the ten years of the experiment. Perennial biomass allocation to vegetative, twig and woody biomass was not differentially affected by elevated [CO2], although leaf area index increased under elevated [CO2]. Similarly, there was no consistent elevated [CO2] effect on yearly production of annual (ephemeral) plants, although an exotic grass (Bromus madritensis subsp. rubens) exhibited a higher relative stimulation in production at elevated [CO2] than did native dicot and grass species. Other studies in our research group have shown that increases in production are only seen in wet years during the ten-year period of CO2 treatments at the NDFF, and so future effects of rising [CO2] may primarily

  20. Couples groups for parents of preschoolers: ten-year outcomes of a randomized trial*

    PubMed Central

    Cowan, Carolyn Pape; Cowan, Philip A.; Barry, Jason

    2011-01-01

    This paper reports the results of a 10-year follow-up of two variations of a couples group preventive intervention offered to couples in the year before their oldest child made the transition to kindergarten. 100 couples were randomly assigned to (1) a low-dose control condition, (2) a couples group meeting for 16 weeks that focused more on couple relationship issues among other family topics, or (3) a couples group meeting for 16 weeks that focused more on parenting issues among other family issues, with an identical curriculum to condition (2). Earlier papers reported that both variations of the intervention produced positive results on parent-child relationships and on the children’s adaptation to kindergarten and 1st grade, and that the groups emphasizing couple relationships also had additional positive effects on couple interaction quality. The present paper uses growth curve analyses to examine intervention effects extending from the children’s transition to kindergarten to the transition to high school – ten years after the couples groups ended. There were 6-year positive effects of the pre-kindergarten interventions on observed couple interaction and 10-year positive effects on both parents’ marital satisfaction and the children’s adaptation (hyperactivity and aggression). Discussion includes a focus on the implications of these results for family policy, clinical practice, and the need to include a couples focus in preventive interventions to strengthen family relationships and enhance children’s adaptation to school. PMID:21480703

  1. Ten years of negotiating rights around maternal health in Uttar Pradesh, India

    PubMed Central

    2011-01-01

    Background Preventable maternal mortality and morbidity have been globally recognized as human rights issues. Maternal mortality in India is among the highest in the world, and reflects inequity in access to healthcare: women from certain states as well as poorer women and less literate women appear to be significantly disadvantaged. The government of India has been attempting to improve maternal outcomes through a cash transfer within the National Rural Health Mission to encourage women to come to hospitals for childbirth. Methods This paper reviews documents of the last ten years describing the experiences of a Non-Governmental Organisation, SAHAYOG, in working with a civil society platform, the Healthwatch Forum, to develop ‘rights based’ strategies around maternal health. The paper builds an analysis using recent frameworks on accountability and gendered rights claiming to examine these experiences and draw out lessons regarding rights claiming strategies for poor women. Results The examination of documents over the last ten years indicates defined phases of development in the evolution of SAHAYOG’s understanding and of the shifts in strategy among SAHAYOG and its close allies, and responses by the state. The first three stages depict the deepening of SAHAYOG’s understanding of the manner in which poor and marginalized women negotiate their access to health care; the fourth stage explores a health system intervention and the challenges of working from within civil society in alliance with poor and marginalized women. Conclusion The findings from SAHAYOG’s experiences with poor Dalit women in Uttar Pradesh reveal the elements of social exclusion within the health system that prevent poor and marginalized women from accessing effective lifesaving care. Creating a voice for the most marginalised and carving space for its articulation impacts upon the institutions and actors that have a duty to meet the claims being made. However, given the accountability

  2. Medical School Attrition-Beyond the Statistics A Ten Year Retrospective Study

    PubMed Central

    2013-01-01

    Background Medical school attrition is important - securing a place in medical school is difficult and a high attrition rate can affect the academic reputation of a medical school and staff morale. More important, however, are the personal consequences of dropout for the student. The aims of our study were to examine factors associated with attrition over a ten-year period (2001–2011) and to study the personal effects of dropout on individual students. Methods The study included quantitative analysis of completed cohorts and qualitative analysis of ten-year data. Data were collected from individual student files, examination and admission records, exit interviews and staff interviews. Statistical analysis was carried out on five successive completed cohorts. Qualitative data from student files was transcribed and independently analysed by three authors. Data was coded and categorized and key themes were identified. Results Overall attrition rate was 5.7% (45/779) in 6 completed cohorts when students who transferred to other medical courses were excluded. Students from Kuwait and United Arab Emirates had the highest dropout rate (RR = 5.70, 95% Confidence Intervals 2.65 to 12.27;p < 0.0001) compared to Irish and EU students combined. North American students had a higher dropout rate than Irish and EU students; RR = 2.68 (1.09 to 6.58;p = 0.027) but this was not significant when transfers were excluded (RR = 1.32(0.38, 4.62);p = 0.75). Male students were more likely to dropout than females (RR 1.70, .93 to 3.11) but this was not significant (p = 0.079). Absenteeism was documented in 30% of students, academic difficulty in 55.7%, social isolation in 20%, and psychological morbidity in 40% (higher than other studies). Qualitative analysis revealed recurrent themes of isolation, failure, and despair. Student Welfare services were only accessed by one-third of dropout students. Conclusions While dropout is often multifactorial, certain red

  3. Ten years after : the status of the saw-tooth pattern

    NASA Astrophysics Data System (ADS)

    Meynadier, L.; Valet, J. P.

    2003-04-01

    One of the most surprising and exciting result emerging from paleomagnetic analyses of long sequences from the ODP Leg 138 in the eastern equatorial Pacific was the asymmetrical saw-toothed shape of the field intensity variations. The curves published ten years ago provided the first continuous record of relative paleointensity which covered the past 4 Ma across a long succession of geomagnetic reversals. Several controversies have been raised up regarding the fact that the field would decrease slowly before reversals and exhibit very fast recovery immediately after the transitions. The first one assumes that cumulative unremoved viscous components would be responsible for the observed decrease during most of the polarity intervals. A second possibility is to envisage a progressive reorientation of the magnetic grains caused by differential compaction. We will review the present status of these scenarii and show that, if the first hypothesis can be reasonably ruled out completely, there is yet no firm and definite observation that allows us to discard the second scenario. Ten years after, there is still no duplicate of the entire ODP sequence, but several individual records restricted to shorter time intervals show a similar saw-toothed pattern while some others do not. Because changes in the amplitude depend also on changes in the reponse function of the sediment (which we do not control) a clearer view should emerge by stacking a large number of records within the same time intervals (e.g. the period encompassing the most recent reversals). Records of paleointensity by other techniques are evidently necessary to validate the observations derived from sediments. All detailed records of absolute paleointensity obtained so far from sequences of overlying lava flows show the existence of weak field intensities before the transitions and very high values accompanying the post-transitional dipole recovery. Unfortunately, uncertainties in chronology do not allow us to

  4. Ten-year helium anomaly prior to the 2014 Mt Ontake eruption.

    PubMed

    Sano, Yuji; Kagoshima, Takanori; Takahata, Naoto; Nishio, Yoshiro; Roulleau, Emilie; Pinti, Daniele L; Fischer, Tobias P

    2015-01-01

    Mt Ontake in central Japan suddenly erupted on 27(th) September 2014, killing 57 people with 6 still missing. It was a hydro-volcanic eruption and new magmatic material was not detected. There were no precursor signals such as seismicity and edifice inflation. It is difficult to predict hydro-volcanic eruptions because they are local phenomena that only affect a limited area surrounding the explosive vent. Here we report a long-term helium anomaly measured in hot springs close to the central cone. Helium-3 is the most sensitive tracer of magmatic volatiles. We have conducted spatial surveys around the volcano at once per few years since November 1981. The (3)He/(4)He ratios of the closest site to the cone stayed constant until June 2000 and increased significantly from June 2003 to November 2014, while those of distant sites showed no valuable change. These observations suggest a recent re-activation of Mt Ontake and that helium-3 enhancement may have been a precursor of the 2014 eruption. We show that the eruption was ultimately caused by the increased input of magmatic volatiles over a ten-year period which resulted in the slow pressurization of the volcanic conduit leading to the hydro-volcanic event in September 2014. PMID:26286468

  5. Ten-year helium anomaly prior to the 2014 Mt Ontake eruption

    PubMed Central

    Sano, Yuji; Kagoshima, Takanori; Takahata, Naoto; Nishio, Yoshiro; Roulleau, Emilie; Pinti, Daniele L.; Fischer, Tobias P.

    2015-01-01

    Mt Ontake in central Japan suddenly erupted on 27th September 2014, killing 57 people with 6 still missing. It was a hydro-volcanic eruption and new magmatic material was not detected. There were no precursor signals such as seismicity and edifice inflation. It is difficult to predict hydro-volcanic eruptions because they are local phenomena that only affect a limited area surrounding the explosive vent. Here we report a long-term helium anomaly measured in hot springs close to the central cone. Helium-3 is the most sensitive tracer of magmatic volatiles. We have conducted spatial surveys around the volcano at once per few years since November 1981. The 3He/4He ratios of the closest site to the cone stayed constant until June 2000 and increased significantly from June 2003 to November 2014, while those of distant sites showed no valuable change. These observations suggest a recent re-activation of Mt Ontake and that helium-3 enhancement may have been a precursor of the 2014 eruption. We show that the eruption was ultimately caused by the increased input of magmatic volatiles over a ten-year period which resulted in the slow pressurization of the volcanic conduit leading to the hydro-volcanic event in September 2014. PMID:26286468

  6. Greater ecosystem carbon in the Mojave Desert after ten years exposure to elevated CO2

    NASA Astrophysics Data System (ADS)

    Evans, R. D.; Koyama, A.; Sonderegger, D. L.; Charlet, T. N.; Newingham, B. A.; Fenstermaker, L. F.; Harlow, B.; Jin, V. L.; Ogle, K.; Smith, S. D.; Nowak, R. S.

    2014-05-01

    Carbon dioxide is the main greenhouse gas inducing climate change. Increased global CO2 emissions, estimated at 8.4 Pg C yr-1 at present, have accelerated from 1% yr-1 during 1990-1999 to 2.5% yr-1 during 2000-2009 (ref. ). The carbon balance of terrestrial ecosystems is the greatest unknown in the global C budget because the actual magnitude, location and causes of terrestrial sinks are uncertain; estimates of terrestrial C uptake, therefore, are often based on the residuals between direct measurements of the atmospheric sink and well-constrained models of ocean uptake of CO2 (ref. ). Here we report significant terrestrial C accumulation caused by CO2 enhancement to net ecosystem productivity in an intact, undisturbed arid ecosystem following ten years of exposure to elevated atmospheric CO2. Results provide direct evidence that CO2 fertilization substantially increases ecosystem C storage and that arid ecosystems are significant, previously unrecognized, sinks for atmospheric CO2 that must be accounted for in efforts to constrain terrestrial and global C cycles.

  7. Ten-year helium anomaly prior to the 2014 Mt Ontake eruption

    NASA Astrophysics Data System (ADS)

    Sano, Yuji; Kagoshima, Takanori; Takahata, Naoto; Nishio, Yoshiro; Roulleau, Emilie; Pinti, Daniele L.; Fischer, Tobias P.

    2015-08-01

    Mt Ontake in central Japan suddenly erupted on 27th September 2014, killing 57 people with 6 still missing. It was a hydro-volcanic eruption and new magmatic material was not detected. There were no precursor signals such as seismicity and edifice inflation. It is difficult to predict hydro-volcanic eruptions because they are local phenomena that only affect a limited area surrounding the explosive vent. Here we report a long-term helium anomaly measured in hot springs close to the central cone. Helium-3 is the most sensitive tracer of magmatic volatiles. We have conducted spatial surveys around the volcano at once per few years since November 1981. The 3He/4He ratios of the closest site to the cone stayed constant until June 2000 and increased significantly from June 2003 to November 2014, while those of distant sites showed no valuable change. These observations suggest a recent re-activation of Mt Ontake and that helium-3 enhancement may have been a precursor of the 2014 eruption. We show that the eruption was ultimately caused by the increased input of magmatic volatiles over a ten-year period which resulted in the slow pressurization of the volcanic conduit leading to the hydro-volcanic event in September 2014.

  8. Ten years of the UW high spectral resolution global IR land surface emissivity (UWIREMIS) database

    NASA Astrophysics Data System (ADS)

    Borbas, E. E.; Knuteson, R. O.

    2012-12-01

    The monthly, UW/CIMSS Baseline Fit (BF) global infrared land surface emissivity database has been developed based on combination of the MODIS/MYD11C3 operational emissivity products and some selected laboratory measurements. The database has been available for distribution since 2006 at the http://cimss.ssec.wisc.edu/iremis/ website and includes data from October 2002 at ten wavelengths (3.6, 4.3, 5.0, 5.8, 7.6, 8.3, 9.3, 10.8, 12.1, and 14.3 microns) with 0.05 degree spatial resolution. To derive high spectral resolution emissivity spectra, the UW High Spectral Resolution (HSR) IR Emissivity Algorithm was also developed. This algorithm uses a principal component analysis (PCA) regression from a combination of high spectral resolution laboratory measurements of selected materials, and the above-mentioned UW/CIMSS Baseline Fit (BF) Global Infrared Land Surface Emissivity Database to provide a 5 wavenumber resolution emissivity database at 416 wavenumbers. Applying the UW HSR Emissivity Algorithm to the UW BF emissivity data makes it possible to create a monthly instrument specific emissivity spectrum for any application involving forward model calculations such as retrieval methods and NWP assimilation or for use in studies of surface energy and water balance. This poster introduces the latest updates and results focusing on the ten year-long available dataset.

  9. A characterization of check valve degradation and failure experience in the nuclear power industry: 1984-1990. Volume 1

    SciTech Connect

    Casada, D.A.; Todd, M.D.

    1993-09-01

    Check valve operating problems in recent years have resulted in significant operating transients, increased cost and decreased system availability. As a result, additional attention has beau given to check valves by utilities (resulting in the formation of the Nuclear Industry Check Valve Group), as well as the US Nuclear Regulatory Commission and the American Society of Mechanical Engineers Operation and Maintenance Committee. All these organizations have the fundamental goal of ensuring reliable operation of check valves. A key ingredient to an engineering-oriented reliability improvement effort is a thorough understanding of relevant historical experience. A detailed review of historical failure data, available through the Institute of Nuclear Power Operation`s Nuclear Plant Reliability Data System, has been conducted. The focus of the review is on check valve failures that have involved significant degradation of the valve internal parts. A variety of parameters are considered, including size, age, system of service, method of failure discovery, the affected valve parts, attributed causes, and corrective actions.

  10. Theory-Based Evaluation: Reflections Ten Years On. Theory-Based Evaluation: Past, Present, and Future

    ERIC Educational Resources Information Center

    Rogers, Patricia J.; Weiss, Carol H.

    2007-01-01

    This chapter begins with a brief introduction by Rogers, in which she highlights the continued salience of Carol Weiss's decade-old questions about theory-based evaluation. Theory-based evaluation has developed significantly since Carol Weiss's chapter was first published ten years ago. In 1997 Weiss pointed to theory-based evaluation being mostly…

  11. Ten Years Later: A Follow-Up Study of Professors Still Working after Age 70

    ERIC Educational Resources Information Center

    Dorfman, Lorraine T.

    2009-01-01

    Little is known about the impact of the end of mandatory retirement on professors over the long term. This follow-up study investigated the ten-year experience of professors who chose not to retire from a major research university after the elimination of the age 70 mandatory retirement in 1994. The initial interview study was conducted in 1998…

  12. TOJDE: Electronic Publishing and a Review of Ten Years' Experience in Turkey

    ERIC Educational Resources Information Center

    Ozarslan, Yasin; Balaban-Sali, Jale; Demiray, Ugur

    2012-01-01

    This review examines "The Turkish Online Journal of Distance Education" (TOJDE) over a ten years period from 2000-2010. The study provides an opportunity to examine publishing activities such as number of published articles, authors, research topics and methods, and analyses of TOJDE's website such as time users stay on site and user profiles.…

  13. Teacher Professional Development in "Teaching and Teacher Education" over Ten Years

    ERIC Educational Resources Information Center

    Avalos, Beatrice

    2011-01-01

    A review of publications in "Teaching and Teacher Education" over ten years (2000-2010) on teacher professional development is the subject of the paper. The first part synthesises production referred to learning, facilitation and collaboration, factors influencing professional development, effectiveness of professional development and issues…

  14. "Ten Years On": Making Children Visible in Teacher Education and Ways of Reading Video

    ERIC Educational Resources Information Center

    Burke, Catherine; Cunningham, Peter

    2011-01-01

    "Ten Years On" is a 30-minute video documentary discovered in the course of researching progressive primary education, school architecture and pedagogy. It was locally produced for professional rather than commercial use at a significant historical moment for educational politics and primary practice. Here, we explore the possibilities of using…

  15. Quality of Life in South Africa--The First Ten Years of Democracy

    ERIC Educational Resources Information Center

    Moller, Valerie

    2007-01-01

    South Africa celebrated ten years of democracy in 2004. This special issue of "Social Indicators Research" ("SIR") reviews developments that have impacted on the quality of life of ordinary South Africans during the transition period. The issue updates an earlier volume of "SIR" (Volume 41) published in 1997 and as a stand-alone volume. The…

  16. Ten Years on: Does Graduate Student Promise Predict Later Scientific Achievement?

    ERIC Educational Resources Information Center

    Haslam, Nick; Laham, Simon M.

    2009-01-01

    We examined publication records of 60 social psychologists to determine whether publication record at the time of the PhD (t0) predicted scientific achievement (publication quantity, quality, and impact) ten years later (t10). Publication quantity and quality each correlated moderately across this time-span. Productivity and impact at t10 were…

  17. Changing Course: Ten Years of Tracking Online Education in the United States

    ERIC Educational Resources Information Center

    Allen, I. Elaine; Seaman, Jeff

    2013-01-01

    "Changing Course: Ten Years of Tracking Online Education" in the United States is the tenth annual report on the state of online learning in U.S. higher education. The survey is designed, administered and analyzed by the Babson Survey Research Group. Data collection is conducted in partnership with the College Board. This year's study, like those…

  18. Over Ten Years after the Implementation of the Teacher's Law: Watching and Expecting

    ERIC Educational Resources Information Center

    Li, Yin

    2006-01-01

    It has been over ten years since the "Teacher's Law" took effect on January 1, 1994, and its promulgation and implementation have somewhat helped in protecting teachers' legal rights and interests. Undeniably, however, the "Teacher's Law" is defective in many aspects, such as the absence of teachers' legal identity, its failure to safeguard a…

  19. Mathematical Skills in Undergraduate Students. A Ten-Year Survey of a Plant Physiology Course

    ERIC Educational Resources Information Center

    Llamas, A.; Vila, F.; Sanz, A.

    2012-01-01

    In the health and life sciences and many other scientific disciplines, problem solving depends on mathematical skills. However, significant deficiencies are commonly found in this regard in undergraduate students. In an attempt to understand the underlying causes, and to improve students' performances, this article describes a ten-year survey…

  20. OPEN PELVIC FRACTURES: THE UNIVERSITY OF TENNESSEE MEDICAL CENTER AT KNOXVILLE EXPERIENCE OVER TEN YEARS

    PubMed Central

    Black, Emily Anne; Lawson, Christy M; Smith, Scott; Daley, Brian J

    2011-01-01

    Introduction Open fractures of the pelvis remain a devastating injury with a high mortality and morbidity. Such injuries require an aggressive treatment plan and the coordination of trauma and orthopaedic surgeons to achieve the best outcomes. We report our experience at the University of Tennessee Medical Center at Knoxville with open pelvic fractures over the last ten years. Methods After IRB and institutional approval, we reviewed patients admitted with a diagnosis of open fracture of the pelvis from 1999 to 2009. Demographic and admission data were recorded in the trauma registry (TRACS) of the Level I Trauma Center, serving the 1.2 million people living in the regions of east Tennessee, western North Carolina and southeastern Kentucky. Data on fractures were obtained from review of the medical records and radiographs within the chart Results There were 3053 pelvic fractures from January 1999 to December 2009. There were 231 deaths in this group (6%) and ages ranged from 18 to 89 years old and Injury Severity Scores ranged from 4 to 75, with a mean of 18.3. Seventy five percent of patients were able to be discharged home. Fifty-two fractures were open. There were 43 men and the mean age was 39 years old. Average ISS was 23 and ranged from 5 to 50. There were 10 deaths (19%) and eight patients underwent an-gioembolization for control of bleeding (3 deaths). Motorcycle crashes were the most frequent cause of an open fracture, with lateral compression injuries representing 71%. A defined algorithm for fracture management has been in place and employed to assure adequate resuscitation and fracture care and is presented. Discussion Open pelvic fractures are usually the result of a high energy transfer, and convey a high morbidity and mortality. A defined resuscitation and fixation strategy improves outcome from historical reports. Injuries from penetrating mechanisms are associated with less morbidity and lower mortality. PMID:22096441

  1. Laparoscopic adrenal surgery: ten-year experience in a single institution

    PubMed Central

    2013-01-01

    Background Minimal invasive adrenalectomy has become the procedure of choice to treat adrenal tumors with a benign appearance, ≤ 6 cm in diameter and weighing < 100 g. Authors evaluated medium- and long-term outcomes of laparoscopic adrenalectomy (LA), performed for ten years in a single endocrine surgery unit. Methods We retrospectively reviewed 88 consecutive patients undergone LA for lesions of adrenal glands from 2003 to 2013. The first 30 operations were considered part of the learning curve. Doxazosin was preoperatively administered in case of pheochromocytoma (PCC), while spironolactone and potassium were employed to treat Conn's disease. Perioperative cardiovascular status modifications and surgical and medium- and long-term results were analyzed. Results Forty nine (55.68%) functioning tumors, and one (1.13%) bilateral adrenal disease were identified. In 2 patients (2.27%) a supposed adrenal metastasis was postoperatively confirmed, while in no patients a diagnosis of incidental primitive malignancy was performed. There was no mortality or major post operative complication. The mean operative time was higher during the learning curve. Conversion and morbidity rates were respectively 1.13% and 5.7%. Intraoperative hypertensive crises (≥180/90 mmHg) were observed in 23.5% (4/17) of PCC patients and were treated pharmacologically with no aftermath. There was no influence of age, size and operative time on the occurrence of PCC intraoperative hypertensive episodes. Surgery determined a normalization of the endocrine profile. One single PCC persistence was observed, while in a Conn's patient, just undergone right LA, a left sparing adrenalectomy was performed for a contralateral metachronous aldosteronoma. Conclusions LA, a safe, effective and well tolerated procedure for the treatment of adrenal neoplasms ≤ 6 cm, is feasible for larger lesions, with a similar low morbidity rate. Operative time has improved along with the increase of the experience and of

  2. Ten-year trends in quality and spending for depression: 1996-2005

    PubMed Central

    Fullerton, Catherine A.; Busch, Alisa B.; Normand, Sharon-Lise T.; McGuire, Thomas G.; Epstein, Arnold M.

    2016-01-01

    Context Over the past decade, the introduction of generic versions of newer antidepressants and the release of FDA-warnings regarding suicidality in children, adolescents, and young adults may have had an impact on cost and quality of depression treatment. Objectives To examine longitudinal trends in service use, spending, and treatment quality for depression. Design Observational, trend study. Setting Florida, Medicaid enrollees from July 1996 to June 2006. Subjects Annual cohorts aged 18-64 diagnosed with depression. Main Outcome Measures Mental-health spending adjusted for inflation and case mix and components of mental-health spending, including inpatient, outpatient, and medication expenditures. Quality measures included measures of medication adherence, psychotherapy, and follow-up visits. Results Mental-health spending increased from an average of $2802 per enrollee to $3610 over this time period (29% increase). This increase occurred despite a mean decrease in inpatient spending (from $641 per enrollee to $373) and was driven primarily by an increase in pharmaceutical spending (up 110%) the bulk of which was due to spending on antipsychotics (up 949%). The percentage of enrollees with depression who were hospitalized decreased from 57% to 37% and the percentage using psychotherapy decreased from 9% to 5%. Antidepressant use increased from 82% to 87%, anxiety medication use was unchanged at 64%, and antipsychotic use increased from 27% to 42%. Changes in treatment quality were mixed, with measures of antidepressant use improving slightly, measures examining follow-up visits decreasing, and measures of psychotherapy utilization fluctuating. Conclusions Over a ten-year period, we found a substantial increase in spending for enrollees with depression associated with minimal improvements in quality of care. Antipsychotic use contributed significantly to the increase in spending while contributing little to traditional measures of quality. PMID:22147841

  3. Eclampsia-scenario in a hospital--a ten years study.

    PubMed

    Pal, A; Bhattacharyya, R; Adhikari, S; Roy, A; Chakrabarty, D; Ghosh, P; Banerjee, C

    2011-08-01

    This cross sectional record based institutional study was conducted in the Department of Obstetrics & Gynaecology, Burdwan Medical College, Burdwan over ten years (1999-2008) aiming analysis of eclamptic mothers for evaluation of maternal and perinatal outcome with different anticonvulsant medications. Total 5991 pregnant mothers with eclampsia admitted in the inpatient department of the tertiary care teaching hospital were recruited for the study, irrespective of their previous antenatal check up history. Subjects with known seizure disorders were excluded from the study. The subjects were managed according to standard regimens (Menon, Ph-sodium, diazepam & magnesium sulphate) and results were documented in standardised format. Case fatality rate, mean induction delivery time & birth-weight, perinatal mortality rates were recorded. Study reveals that the incidence of eclampsia <20 years was 6.97% and majority (5.41%) came from rural areas. Eclampsia was noted primarily in primigravida (7.43%) and unbooked (6.41%) mothers. Ante partum eclampsia predominated (64%) and incidence of caesarean section was 22.25%.The overall case fatality rate was 6.05% and eclampsia contributed 27.85% of all maternal deaths during the last two years of the study period. The overall incidence of low birth weight baby was 26.96% and perinatal mortality was 30.33% (1411/4651).The incidence of perinatal mortality and low birth weight babies are lower in the last 4 years when compared to earlier studies. Proper socio-demographic assessment of pregnancy with eclampsia, planned delivery, shorter induction delivery interval, good control of convulsion by magnesium sulphate, intensive intranatal monitoring causes less maternal and perinatal morbidity and mortality. PMID:21877608

  4. [Phenology of forest vegetation in northeast of China in ten years using remote sensing].

    PubMed

    Hou, Xue-Hui; Niu, Zheng; Gao, Shuai

    2014-02-01

    Plant phenology is the best indicator of terrestrial ecosystem response to climate change and it becomes a hot issue in the study of global change. The forest in northeast of China plays an important part in global forest ecosystem. In this paper, yearly integrated Normalized Difference Vegetation Index (NDVI) of forest vegetation in northeast China was calculated based on Spot Vegetation datasets from 2001-2010, which has been filtered using Savtiky-Galoy method. And then, the yearly integrated NDVI profile was fitted using a logistic model. Two key parameters of forest phenology (start of season, SOS; end of season, EOS) were extracted according to the greatest rate of curvature of fitted cumulative NDVI and the length of forest phenology (length of season, LOS) was also analyzed. The main conclusions of this paper are (1) SOS mainly occurs in the 110th-140th day and EOS in 260th and 290th day. SOS displays a marked delayed from south to north while EOS gradually advances. However, the changes of SOS and EOS in ten years are not obvious. (2) Corresponding to the SOS and EOS, LOS of forest in study area mainly occurs in the 120th-160th day; however, it is spatially heterogeneous. LOS of forest in Greater Khingan Mountains is shorter (about 120-140 day) than forests in Xiao Hinggan Ling and Changbai Mountains (about 160 day). The results in this paper are concordant with records of phenology in situ measurements and previous researches in the same area. It indicates that forest phenophases using method in this paper from Spot Vegetation dataset is feasible. PMID:24822431

  5. Ten years of RELEA: achievements and challenges for astronomy education development

    NASA Astrophysics Data System (ADS)

    Bretones, Paulo Sergio; Jafelice, Luiz Carlos; Horvath, Jorge Ernesto

    2015-08-01

    When an area of education, and more particularly the research within this area, is aimed to development, a basic requirement is the existence of a regular publication that accounts for the scientific production in that area. This study aims to analyze 10 years of Latin-American Journal of Astronomy Education (RELEA). Publishing policies of the RELEA and their context are discussed in relation to submission, refereeing and publication. The 75 articles published in 18 editions are analyzed and classified by: year of publication, edition, the authors' institutions, school level, study focus and content. The results present trends and shortcomings of the production. A comparison with the number of articles published in other Brazilian journals of education and an analysis of the international scene in relation to other type publications along these ten years is made. Given that this journal is now consolidated, its future prospects in the international landscape are further considered. The challenges related to article submission are discussed: how to increase their number, the submission of Latin American countries, and how to bring in the issues and subjects not addressed until now. It is also considered the possibility of encouraging graduate studies, new lines of research in astronomy education, and dissemination of material in schools and universities for teachers and students. Finally, future possibilities are discussed given the IAU development programs. For example, more article submission from Portuguese-speaking countries with the support of Regional Nodes and Language Expertise Centers, and opportunities for volunteer IAU members and global projects for the development of astronomy education.

  6. Review of ten-years presence of Aedes albopictus in Spain 2004-2014: known distribution and public health concerns.

    PubMed

    Collantes, Francisco; Delacour, Sarah; Alarcón-Elbal, Pedro María; Ruiz-Arrondo, Ignacio; Delgado, Juan Antonio; Torrell-Sorio, Antonio; Bengoa, Mikel; Eritja, Roger; Miranda, Miguel Ángel; Molina, Ricardo; Lucientes, Javier

    2015-01-01

    Ten years have gone by since the Asian tiger mosquito Aedes albopictus was recorded for the first time in Spain. In this paper, all relevant published information about this vector in Spain for the period 2004-2014 is reviewed. The known distribution for 2014 is provided, including all historical records (published and unpublished data) and the results from samplings of the last year. The consequences on public health about the presence of the Asian tiger mosquito in Spain are also highlighted. Further, legal aspects and control plans related to the management and diseases transmitted by this invasive vector species are also discussed. PMID:26694818

  7. Contamination Control Changes to the Reusable Solid Rocket Motor Program: A Ten Year Review

    NASA Technical Reports Server (NTRS)

    Bushman, David M.

    1998-01-01

    During the post Challenger period, the National Aeronautics and Space Administration and Thiokol implemented changes to the Reusable Solid Rocket Motor (RSRM) contract to include provisions for contamination control to enhance the production environment. During the ten years since those agreements for contamination controls were made, many changes have taken place in the production facilities at Thiokol. These changes have led to the production of much higher quality shuttle solid rocket motors and improved cleanliness and safety of operations in the production facilities. The experience in contamination control over this past decade highlights the value these changes have brought to the RSRM program, and how the system can be improved to meet the challenges the program will face in the next ten years.

  8. Ten Commandments Revisited: A Ten-Year Perspective on the Industrial Application of Formal Methods

    NASA Technical Reports Server (NTRS)

    Bowen, Jonathan P.; Hinchey, Michael G.

    2005-01-01

    Ten years ago, our 1995 paper Ten Commandments of Formal Methods suggested some guidelines to help ensure the success of a formal methods project. It proposed ten important requirements (or "commandments") for formal developers to consider and follow, based on our knowledge of several industrial application success stories, most of which have been reported in more detail in two books. The paper was surprisingly popular, is still widely referenced, and used as required reading in a number of formal methods courses. However, not all have agreed with some of our commandments, feeling that they may not be valid in the long-term. We re-examine the original commandments ten years on, and consider their validity in the light of a further decade of industrial best practice and experiences.

  9. Ten Years of Northern Eurasia Earth Science Partnership Initiative (NEESPI): Results and Future Plans

    NASA Astrophysics Data System (ADS)

    Groisman, P. Y.; Gutman, G.; Gulev, S.; Maksyutov, S. S.

    2014-12-01

    During recent decades, Northern Eurasia was affected by unprecedented climate and environmental changes. Several droughts and heat waves alternated with hazardous extreme precipitation and flood events. Permafrost thaw, retreating Arctic sea ice, increasing areas of forest fire, and dramatic regional warming buffeted this region, tossing northern Eurasia from one extreme condition to the next. The region stores nearly half of the Earth's terrestrial carbon in permafrost, wetlands, and forested land, so ecosystem changes that release stored carbon could profoundly affect the world's climate. Furthermore, changes to climate and to hydrological and biogeochemical cycles are starting to affect daily life. For example, infrastructure is collapsing as permafrost thaws, severe winter storms increasingly bring businesses to a halt, and a growing water deficit is beginning to strain agricultural production and forestry. To pool resources and facilitate research, the Northern Eurasia Earth Science Partnership Initiative (NEESPI, http://neespi.org) was launched in 2004. With its multidisciplinary focus, the internationally funded NEESPI (more than165 individual international projects during the past decade) has challenged participants to research climate-ecosystem interactions, societal impacts from extreme events in Northern Eurasia, and the feedbacks of these interactions and impacts to the global Earth system. Among the numerous Institutional and private sponsors from the United States, European Union, Russia, China, and Japan, the cornerstone support for the NEESPI studies was provided by the NASA Land Cover and Land Use Change Program and the Russian Academy of Sciences. At this presentation we shall overview the environmental studies conducted by the NEESPI community, brief the audience about the main achievements of the NEESPI researchers, and lay down the plans for the future studies. At the side event of the Meeting, we are going to initiate preparation of the book which will synthesize major NEESPI achievements.

  10. Neurobiology of Developmental Dyslexia: Results of a Ten Year Research Program.

    ERIC Educational Resources Information Center

    Galaburda, Albert M.

    1997-01-01

    This paper summarizes research currently being conducted on the biologic underpinnings of learning disorders, particularly dyslexia. The research findings discussed are derived from studying neuroanatomic, neurophysiologic, neurogenetic, neuroimaging, and behavioral characteristics in animal models that exhibit developmental brain anomalies and…

  11. A rare suicidal case of a ten-year-old child stabbing himself in the throat.

    PubMed

    Hasekura, H; Fukushima, H; Yonemura, I; Ota, M

    1985-10-01

    A rare case is reported of a ten-year-old boy who committed suicide by stabbing himself in the throat with a pointed knife. Possibility of an accidental injury was excluded by the autopsy findings; suspicion of a homicide by his father was cleared through the deposition of his sister. The reason of suicide was attributed directly to his father's severe scolding and indirectly to his mother's death two years before. PMID:4067552

  12. [Ten years of literature review in general internal medicine--a first assessment].

    PubMed

    Pasche, O; Senn, N; Bugnon, O; Cornuz, J; Bodenmann, P

    2015-01-21

    A group of family physicians in an outpatient clinic in Switzerland prospectively followed scientific literature for ten years. What to remember among the numerous articles retrieved and which paper really changed our practice? If many readings are quickly forgotten, some of them marked our minds and changed our habits. This article is a summary of our efforts to keep the essential tools in clinical practice. PMID:25831612

  13. Massachusetts Health Reform At Ten Years: Great Progress, But Coverage Gaps Remain.

    PubMed

    Long, Sharon K; Skopec, Laura; Shelto, Audrey; Nordahl, Katharine; Walsh, Kaitlyn Kenney

    2016-09-01

    Massachusetts's 2006 health reform legislation was intended to move the state to near-universal health insurance coverage and to improve access to affordable health care. Ten years on, a large body of research demonstrates sustained gains in coverage. But many vulnerable populations and communities in the state have high uninsurance rates, and among those with coverage, gaps in access and affordability persist. PMID:27605643

  14. Ten-year monitoring of high-rise building columns using long-gauge fiber optic sensors

    NASA Astrophysics Data System (ADS)

    Glisic, B.; Inaudi, D.; Lau, J. M.; Fong, C. C.

    2013-05-01

    A large-scale lifetime building monitoring program was implemented in Singapore in 2001. The monitoring aims of this unique program were to increase safety, verify performance, control quality, increase knowledge, optimize maintenance costs, and evaluate the condition of the structures after a hazardous event. The first instrumented building, which has now been monitored for more than ten years, is presented in this paper. The long-gauge fiber optic strain sensors were embedded in fresh concrete of ground-level columns, thus the monitoring started at the birth of both the construction material and the structure. Measurement sessions were performed during construction, upon completion of each new story and the roof, and after the construction, i.e., in-service. Based on results it was possible to follow and evaluate long-term behavior of the building through every stage of its life. The results of monitoring were analyzed at a local (column) and global (building) level. Over-dimensioning of one column was identified. Differential settlement of foundations was detected, localized, and its magnitude estimated. Post-tremor analysis was performed. Real long-term behavior of concrete columns was assessed. Finally, the long-term performance of the monitoring system was evaluated. The researched monitoring method, monitoring system, rich results gathered over approximately ten years, data analysis algorithms, and the conclusions on the structural behavior and health condition of the building based on monitoring are presented in this paper.

  15. Outcomes of Open Carpal Tunnel Release at a Minimum of Ten Years

    PubMed Central

    Louie, Dexter L.; Earp, Brandon E.; Collins, Jamie E.; Losina, Elena; Katz, Jeffrey N.; Black, Eric M.; Simmons, Barry P.; Blazar, Philip E.

    2013-01-01

    Background: There is little research on the long-term outcomes of open carpal tunnel release. The purpose of this retrospective study was to determine the functional and symptomatic outcomes of patients at a minimum of ten years postoperatively. Methods: Two hundred and eleven patients underwent open carpal tunnel release from 1996 to 2000 performed by the same hand fellowship-trained surgeon. Follow-up with validated self-administered questionnaire instruments was conducted an average of thirteen years after surgery. The principal outcomes included the Levine-Katz symptom and function scores, ranging from 1 point (best) to 5 points (worst), and satisfaction with the results of surgery. The patients self-reported current comorbidities. Results: After a mean follow-up of thirteen years (range, eleven to seventeen years), 92% (194) of 211 patients were located. They included 140 who were still living and fifty-four who had died. Seventy-two percent (113) of the 157 located, surviving patients responded to the questionnaire. The mean Levine-Katz symptom score (and standard deviation) was 1.3 ± 0.5 points, and 13% of patients had a poor symptom score (≥2 points). The mean Levine-Katz function score was 1.6 ± 0.8 points, and 26% had a poor function score (≥2 points). The most common symptom-related complaint was weakness in the hand, followed by diurnal pain, numbness, and tingling. The least common symptoms were nocturnal pain and tenderness at the incision. Eighty-eight percent of the patients were either completely satisfied or very satisfied with the surgery. Seventy-four percent reported their symptoms to be completely resolved. Thirty-three percent of men were classified as having poor function compared with 23% of women. Two (1.8%) of 113 patients underwent repeat surgery. Conclusions: At an average of thirteen years after open carpal tunnel release, the majority of patients are satisfied and free of symptoms of carpal tunnel syndrome. Level of Evidence

  16. Campylobacter antimicrobial resistance in Peru: a ten-year observational study

    PubMed Central

    2012-01-01

    Background Campylobacter jejuni and Campylobacter coli are food-borne pathogens of great importance and feature prominently in the etiology of developing world enteritis and travellers’ diarrhoea. Increasing antimicrobial resistant Campylobacter prevalence has been described globally, yet data from Peru is limited. Our objective was to describe the prevalence trends of fluoroquinolone and macrolide-resistant C. jejuni and C. coli stool isolates from three regions in Peru over a ten-year period. Methods Surveillance for enteric pathogens was conducted in Lima, Iquitos and Cusco between 2001 and 2010. Campylobacter stool isolates were tested for susceptibilities to ciprofloxacin, azithromycin and erythromycin. Susceptibilities were reviewed for 4652 isolates from Lima ( n = 3419), Iquitos ( n = 625) and Cusco ( n = 608). Results Comparing the study periods of 2001-2005 and 2006-2010, prevalence of ciprofloxacin-resistant C. jejuni isolates rose in the study areas of Lima (73.1% to 89.8%, p < 0.001) and Iquitos (24.1% to 48.9%, p < 0.001). Ciprofloxacin-resistant C. coli rates also increased in Lima (48.1% to 87.4%, p < 0.001) and Cusco (10.0% to 65.9%, p = 0.005). Small but significant increases in azithromycin-resistant and erythromycin-resistant C. jejuni prevalence were noted in Iquitos (2.2% to 14.9%, p < 0.001; 3.2% to 14.9%, p = 0.002), and erythromycin-resistant C. coli rates increased in Lima (0.0% to 5.3%, p = 0.038). The prevalence of C. jejuni isolates resistant to both ciprofloxacin and azithromycin increased in Iquitos (0.3% to 14.9%, p < 0.001) and Lima (0.3% to 1.6%, p = 0.011), and prevalence of C. jejuni isolates resistant to both ciprofloxacin and erythromycin rose in Iquitos (0.0% to 14.9%, p < 0.001). Ciprofloxacin and erythromycin resistant C. coli prevalence increased in Lima (0.0% to 5.3%, p = 0.034). Conclusions These results have implications for the empirical management of

  17. 78 FR 46552 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ...; Second Ten-Year Carbon Monoxide Maintenance Plan for Colorado Springs AGENCY: Environmental Protection... Colorado Springs area for the carbon monoxide (CO) National Ambient Air Quality Standard (NAAQS)....

  18. Idaho National Laboratory 2013-2022 Ten-Year Site Plan

    SciTech Connect

    Calvin Ozaki; Sheryl L. Morton; Elizabeth A. Connell; William T. Buyers; Craig L. Jacobson; Charles T. Mullen; Christopher P. Ischay; Ernest L. Fossum; Robert D. Logan

    2011-06-01

    The Idaho National Laboratory (INL) Ten-Year Site Plan (TYSP) describes the strategy for accomplishing the long-term objective of transforming the laboratory to meet Department of Energy (DOE) national nuclear research and development (R&D) goals, as outlined in DOE strategic plans. The plan links R&D mission goals and INL core capabilities with infrastructure requirements (single- and multi-program), establishs the 10-year end-state vision for INL complexes, and identifies and prioritizes infrastructure needs and capability gaps. The TYSP serves as the basis for documenting and justifying infrastructure investments proposed as part of the FY 2013 budget formulation process.

  19. Dopa-Responsive Dystonia in a Ten-Year-Old Girl

    PubMed Central

    Soma, Venkatesh; Mohammed, Hussain Sadiq; Riyas, Ebrahim; Murugesan, Karuppasamy

    2012-01-01

    Children with recent onset dystonia and gait abnormalities may pose a diagnostic challenge. A ten-year-old, developmentally normal girl, presented with a six-month history of gait abnormality and dystonia. Her complaint worsened as the day progressed. In view of typical diurnal variation of dystonia, a therapeutic challenge with levodopa/carbidopa was given and there was a dramatic response. Hence, a diagnosis of dopa-responsive dystonia (DRD) was made. DRD is an inherited disorder characterized by dystonia with diurnal variation and favorable response to levodopa/carbidopa. The inheritance is usually autosomal dominant, however, in some cases, autosomal-recessive inheritance is also seen. PMID:24479026

  20. 76 FR 9786 - NIOSH Dose Reconstruction Program Ten-Year Review-Phase I Report on Customer Service; Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention NIOSH Dose Reconstruction Program Ten-Year... review and comment on the draft publication, ``NIOSH Dose Reconstruction Program Ten-Year Review--Phase...

  1. Ten-year forecasts of water quality in Lake Michigan using a deterministic eutrophication model

    SciTech Connect

    Lesht, B.M.

    1984-03-01

    A dynamic, deterministic lake eutrophication model was used to forecast changes in Lake Michigan water quality over a ten-year simulation period. Emphasis was placed on changes in epiliminon phytoplankton biomass and in whole-lake total phosphorus concentration in response to changes in input phosphorus loads and to variations in winter conditions. Constant-condition simulations corresponding to current, increased, and reduced loads and to mild, average, and severe winters were used to establish bounds for the projected changes in water quality. Monte Carlo-type simulations were used to estimate the variance associated with the projections. Given the assumptions and limitations inherent in the modeling process, water quality in Lake Michigan is projected to improve slightly (reduced concentrations of phytoplankton and total phosphorus) over the next ten years. Year-to-year variations are significant, however, and will depend on loading and winter conditions. The variation in the projected values associated with the assumed fluctuations in loads and winter conditions is approximately 20 percent. 25 references, 20 figures, 4 tables.

  2. Idaho National Laboratory 2015-2023 Ten-Year Site Plan

    SciTech Connect

    Sheryl Morton; Elizabeth Connell; Bill Buyers; John Reisenauer; Rob Logan; Chris Ischay; Ernest Fossum; Paul Contreras; Joel Zarret; Steve Hill; Jon Tillo

    2013-09-01

    This Idaho National Laboratory (INL) Ten-Year Site Plan (TYSP) describes the strategy for accomplishing the long-term objective of sustaining the INL infrastructure to meet the Department of Energy Office of Nuclear Energy (DOE-NE) mission: to promote nuclear power as a resource capable of making major contributions in meeting the nation’s energy supply, environmental and energy security needs. This TYSP provides the strategy for INL to accomplish its mission by: (1) linking R&D mission goals to core capabilities and infrastructure requirements; (2) establishing a ten-year end-state vision for INL facility complexes; (3) identifying and prioritizing infrastructure needs and capability gaps; (4) establishing maintenance and repair strategies that allow for sustainment of mission-critical (MC) facilities; and (5) applying sustainability principles to each decision and action. The TYSP serves as the infrastructure-planning baseline for INL; and, though budget formulation documents are informed by the TYSP, it is not itself a budget document.

  3. ``Long-life`` aluminium brazing alloys for automotive radiators -- a ten-year retrospective

    SciTech Connect

    Scott, A.C.; Woods, R.A.

    1998-12-31

    A class of corrosion-resistant brazing sheet materials, generally referred to as ``long-life alloys,`` has been in widespread use in brazed aluminum automobile radiators for over ten years. K319 tube material was initially introduced in 1986 to address the problem of road-salt-induced, outside-in corrosion of tubes in vacuum-brazed aluminum radiators, The development history, metallurgy, and field performance of long-life radiator brazing sheet are reviewed. This material utilizes the familiar sacrificial layer concept to improve corrosion resistance; however, it is unusual in that the layer is not introduced by conventional cladding means during sheet manufacture, but rather develops in situ by metallurgical transformations which occur during the brazing cycle. The sacrificial layer, about 25 mV anodic to the core alloy, increases by an order of magnitude the time-to-perforation of radiator tube sheet tested in cyclic acidified salt spray (SWAAT), which mimics the corrosion morphology observed in the field. Radiators examined after ten years of field service show excellent corrosion resistance, as predicted by SWAAT.

  4. A Ten Year Retrospective on Environmental Justice: What Have We Learned?

    SciTech Connect

    Scott, Michael J.; Jaksch, John A.; Cort, Katherine A.

    2005-03-01

    Beginning in 1994, Executive Order 12898 has directed federal executive agencies to identify and address, as appropriate, disproportionately high and adverse health or environmental effects of their programs, policies, and activities on minority and low income populations. The policy behind the Executive Order was to prevent minority and low income groups from bearing disproportionate adverse environmental consequences of federal actions. During the last ten years, federal agencies have implemented Executive Order 12898, and some also have developed explicit procedures or guidance for the steps that need to be taken during the preparation of environmental impact statements. Based on the authors’ experience, the paper examines how environmental justice practice has evolved in the ten years since the original Executive Order was issued. This evolution has been both procedural and substantive. The paper examines how the actual practice of environmental justice analysis has progressed in federal agencies that deal with waste management issues. Reference is made to changes in case law and agency practice. The 2000 Census of Population and the ongoing development of geographic information systems in particular have made it easier to identify minority and low-income populations at risk. At the same time, a number of stakeholder groups have taken positions over specific federal actions that have given rise to novel issues and challenges for analysts. The paper discusses how NEPA practice is evolving to deal with these issues and challenges.

  5. Scientific publications in pediatrics over the last ten years in Turkey and worldwide.

    PubMed

    Altun, Demet; Dabak, Orçun; Hacıhamdioğlu, Duygu Övünç

    2015-01-01

    In keeping with the large area of interest comprised within the field of pediatrics, the number and diversity of publications in this field has gradually increased over the last ten years in our country as well as worldwide. The objective of this paper is to offer an analysis of the status of pediatrics publications during those ten years. The publications analyzed were listed in the Thomson Reuters Web of Science and/or published in journals included in the Science Citation Index, the Science Citation Index Expanded and the Social Sciences Citation Index. All of these publications appeared in journals in which at least one pediatrics specialist published between the years 2004 and 2013. It may be seen that Turkey is in fifth place worldwide in terms of the number of studies published in these journals, with 6,134 such publications. The conclusion is that it is necessary for more Turkish studies to be multicenter, to involve international participation and to receive more citations; importance must be attached to the objective of transforming of the knowledge produced by Turkish researchers into a greater number of publications of increased quality. PMID:26690590

  6. Clinical characteristics and prognosis of childhood rhabdomyosarcoma: a ten-year retrospective multicenter study

    PubMed Central

    Ma, Xiaoli; Huang, Dongsheng; Zhao, Weihong; Sun, Liming; Xiong, Hao; Zhang, Yi; Jin, Mei; Zhang, Dawei; Huang, Cheng; Wang, Huanmin; Zhang, Weiping; Sun, Ning; He, Lejian; Tang, Jingyan

    2015-01-01

    Purpose: Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children. We have retrospectively explored the treatment results of childhood RMS and identified prognostic factors in multicenter in China, in order to lay the foundation for further multicenter study. Methods: This retrospective study was carried out analyzing the medical records of 161 patients with the pathological diagnosis of RMS from January, 2001 to February, 2014 at 5 large cancer centers in China. The data was reviewed clinico-epidemiological factors. Age, gender, histology type, primary site, tumor size, intergroup rhabdomyosarcoma study (IRS) group and results of treatments were evaluated. Patients were followed up to Dec 31, 2014. Results: The median age of our patients was 51 months. 10.5% of our patients were infants. The genitourinary system was the most common primary site of tumor (43.5%). The proportion of primary site of head and neck except parameningeal, at 28.2% (42 cases), while the proportion of parameningeal region was 4.6% (7 cases). The histological findings were as follows: 130 cases (80.7%) with embryonal, 19 cases (11.9%) with alveolar and 5 cases (3.1%) with botryoid type. According to the classification system of the IRS group, 1 case (0.6%) was group I, 54 cases (33.5%) were group II, 46 cases (28.6%) were group III and 60 cases (37.3 %) were group IV. 149 patients were treated and followed-up regularly, Patients in Beijing children’s hospital (n=95) were enrolled in IRS-II/COG-D9803, D9802 protocols. while the other patients (n=54) started on treatment according to Chinese Anti-cancer Association protocol. There were median time of 51 months for following up, 60 occurred event. The ten-year event free survival rate was 53.4±5.1%, overall survival was 65.3±6.3%. The relations between outcome and age (0.046), primary site (0.022), pathologic subtype (0.013), tumor size (0.008) and IRS group (P=0.000) were associated significantly with event free survival

  7. Switching To Less-Expensive Blindness Drug Could Save Medicare Part B $18 Billion Over A Ten-Year Period

    PubMed Central

    Hutton, DW; Newman-Casey, PA; Tavag, M; Zacks, DN; Stein, JD

    2014-01-01

    The biologic drugs bevacizumab and ranibizumab have revolutionized treatment of diabetic macular edema and macular degeneration, leading causes of blindness. Ophthalmologic use of these drugs has increased, now accounting for roughly one-sixth of the Medicare Part B drug budget. Ranibizumab and bevacizumab have similar efficacy and potentially minor differences in adverse event rates, but at $2,023 per dose, ranibizumab costs forty times more than bevacizumab. Using modeling methods, we predict ten-year (2010–2020) population-level costs and health benefits of using bevacizumab and ranibizumab. Our results show that if all patients were treated with the less-expensive bevacizumab instead of current usage patterns, Medicare Part B, patients, and the health care system would save $18 billion, $4.6 billion, and $29 billion, respectively. Altering patterns of use with these therapies by encouraging bevacizumab use and hastening approval of biosimilar therapies would dramatically reduce spending without substantially affecting patient outcomes. PMID:24889941

  8. Surgical Brain Metastases: Management and Outcome Related to Prognostic Indexes: A Critical Review of a Ten-Year Series

    PubMed Central

    Caroli, Manuela; Di Cristofori, Andrea; Lucarella, Francesca; Raneri, Fabio Angelo; Portaluri, Francesco; Gaini, Sergio Maria

    2011-01-01

    Brain metastasis are the most common neoplastic lesions of the nervous system. Many cancer patients are diagnosed on the basis of a first clinical presentation of cancer on the basis of a single or multiple brain lesions. Brain metastases are manifestations of primary disease progression and often determine a poor prognosis. Not all patients with a brain metastases undergo surgery: many are submitted to alternative or palliative treatments. Management of patients with brain metastases is still controversial, and many studies have been developed to determine which is the best therapy. Furthermore, management of patients operated for a brain metastasis is often difficult. Chemotherapy, stereotactic radiosurgery, panencephalic radiation therapy, and surgery, in combination or alone, are the means most commonly used. We report our experience in the management of a ten-year series of surgical brain metastasis and discuss our results in the preoperative and postoperative management of this complex condition. PMID:22084749

  9. Ten-year interannual and seasonal variability of stream carbon export from a boreal peatland in northern Sweden

    NASA Astrophysics Data System (ADS)

    Leach, J.; Larsson, A.; Nilsson, M. B.; Laudon, H.

    2015-12-01

    High latitude peatlands constitute about 3% of the global land cover but store almost a third of the global soil carbon pool. The annual net ecosystem carbon balance at high latitude mires results from the balance between net ecosystem exchange, methane emission and stream discharge export. Understanding stream carbon export dynamics is needed to accurately predict how the carbon balance of peatlands will respond to climatic and environmental change. We use a ten year record (2004-2014) of streamflow and dissolved carbon (DOC, DIC, and CH4) measurements to assess interannual and seasonal variability in stream carbon export for a peatland catchment in northern Sweden. Mean annual total carbon export for the ten year period was 11.4 gC/m2, but individual years ranged between 6.1 and 17.2 gC/m2. DOC was the dominant form of carbon being exported, comprising 68% to 76% of total annual exports, and DIC contributed between 24% and 30%. CH4 made up less than 3% of total export. Stream carbon export and streamflow were highly synchronous. The majority of export (30% to 55% of annual totals) occurred during the spring snowmelt period. Exports during the summer and autumn were highly variable (1% to 45% and 9% to 53% of annual totals, respectively) and depended on the timing and magnitude of rain events. Winter periods were characterized by low streamflow conditions and associated low carbon export (0.6% to 10% of annual totals). These results highlight considerable interannual and seasonal variability of stream carbon export driven primarily by rain and snowmelt runoff events.

  10. Analysis of web-related threats in ten years of logs from a scientific portal

    NASA Astrophysics Data System (ADS)

    Santos, Rafael D. C.; Grégio, André R. A.; Raddick, Jordan; Vattki, Vamsi; Szalay, Alex

    2012-06-01

    SkyServer is an Internet portal to data from the Sloan Digital Sky Survey, the largest online archive of astronomy data in the world. provides free access to hundreds of millions of celestial objects for science, education and outreach purposes. Logs of accesses to SkyServer comprise around 930 million hits, 140 million web services accesses and 170 million SQL submitted queries, collected over the past 10 years. These logs also contain indications of compromise attempts on the servers. In this paper, we show some threats that were detected in ten years of stored logs, and compare them with known threats in those years. Also, we present an analysis of the evolution of those threats over these years.

  11. Perspective: The first ten years of broadband chirped pulse Fourier transform microwave spectroscopy.

    PubMed

    Park, G Barratt; Field, Robert W

    2016-05-28

    Since its invention in 2006, the broadband chirped pulse Fourier transform spectrometer has transformed the field of microwave spectroscopy. The technique enables the collection of a ≥10 GHz bandwidth spectrum in a single shot of the spectrometer, which allows broadband, high-resolution microwave spectra to be acquired several orders of magnitude faster than what was previously possible. We discuss the advantages and challenges associated with the technique and look back on the first ten years of chirped pulse Fourier transform spectroscopy. In addition to enabling faster-than-ever structure determination of increasingly complex species, the technique has given rise to an assortment of entirely new classes of experiments, ranging from chiral sensing by three-wave mixing to microwave detection of multichannel reaction kinetics. However, this is only the beginning. Future generations of microwave experiments will make increasingly creative use of frequency-agile pulse sequences for the coherent manipulation and interrogation of molecular dynamics. PMID:27250271

  12. Perspective: The first ten years of broadband chirped pulse Fourier transform microwave spectroscopy

    NASA Astrophysics Data System (ADS)

    Park, G. Barratt; Field, Robert W.

    2016-05-01

    Since its invention in 2006, the broadband chirped pulse Fourier transform spectrometer has transformed the field of microwave spectroscopy. The technique enables the collection of a ≥10 GHz bandwidth spectrum in a single shot of the spectrometer, which allows broadband, high-resolution microwave spectra to be acquired several orders of magnitude faster than what was previously possible. We discuss the advantages and challenges associated with the technique and look back on the first ten years of chirped pulse Fourier transform spectroscopy. In addition to enabling faster-than-ever structure determination of increasingly complex species, the technique has given rise to an assortment of entirely new classes of experiments, ranging from chiral sensing by three-wave mixing to microwave detection of multichannel reaction kinetics. However, this is only the beginning. Future generations of microwave experiments will make increasingly creative use of frequency-agile pulse sequences for the coherent manipulation and interrogation of molecular dynamics.

  13. FCC reactor product-catalyst separation: Ten years of commercial experience with closed cyclones

    SciTech Connect

    Miller, R.B.; Johnson, T.E.; Santner, C.R.; Avidan, A.A.; Johnson, D.L.

    1995-09-01

    FCC reactor closed cyclones were first commercialized ten years ago and have now been installed in over 22 FCC units worldwide. Cumulative commercial experience has shown significant yield benefits, in some cases higher than first estimated, and excellent reliability. By nearly eliminating post-riser cracking, they reduce dry gas make and produce higher yields of desirable liquid products. Trouble-free operation with closed cyclones is attributed to proper design, instrumentation, and operating procedures. The Mobil-Kellogg Closed Cyclone technology is the only design offered for license which uses the positive-pressure riser cyclone system which has proven to be least sensitive to upsets. This paper traces the development and commercialization of closed cyclones, discusses differences between competing closed cyclone designs, and documents the benefits which have been observed for Mobil-Kellogg Closed Cyclones.

  14. Idaho National Laboratory Ten-Year Site Plan Project Description Document

    SciTech Connect

    Not Listed

    2012-03-01

    This document describes the currently active and proposed infrastructure projects listed in Appendix B of the Idaho National Laboratory 2013-2022 Ten Year Site Plan (DOE/ID-11449). It was produced in accordance with Contract Data Requirements List I.06. The projects delineated in this document support infrastructure needs at INL's Research and Education Campus, Materials and Fuels Complex, Advanced Test Reactor Complex and the greater site-wide area. The projects provide critical infrastructure needed to meet current and future INL opereational and research needs. Execution of these projects will restore, rebuild, and revitalize INL's physical infrastructure; enhance program execution, and make a significant contribution toward reducing complex-wide deferred maintenance.

  15. NGF deprivation-induced gene expression: after ten years, where do we stand?

    PubMed

    Freeman, Robert S; Burch, Robert L; Crowder, Robert J; Lomb, David J; Schoell, Matthew C; Straub, Jennifer A; Xie, Liang

    2004-01-01

    Nerve growth factor (NGF) is required for the survival of developing sympathetic and sensory neurons. In the absence of NGF, these neurons undergo protein synthesis-dependent apoptosis. Ten years have gone by since the first reports of specific genes being upregulated during NGF deprivation-induced cell death. Over the last decade, a few additional genes (DP5, Bim, SM-20) have been added to a list that began with cyclin D1 and c-jun. In this chapter, we discuss the evidence that these genes act as regulators of neuronal cell death. We also suggest a hypothesis for how one gene, SM-20, may function to suppress a self-protection mechanism in NGF-deprived neurons. PMID:14699960

  16. Deep Vadose Zone Characterization at the Hanford Site: Accomplishments from the Last Ten Years

    SciTech Connect

    Brown, C.F.; Serne, R.J.

    2008-07-01

    The overall goal of the Tank Farm Vadose Zone Project, led by CH2M HILL Hanford Group, Inc., is to define risks from past and future single-shell tank farm activities at Hanford. To meet this goal, CH2M HILL Hanford Group, Inc. tasked scientists from Pacific Northwest National Laboratory (PNNL) to perform detailed analyses on vadose zone sediments collected within/adjacent to the twelve single-shell tank farms contained within Hanford's Central Plateau region. This work has been performed under the Resource Conservation and Recovery Act (RCRA) Corrective Action Program and is associated with the Hanford Federal Facility Agreement and Consent Order. While there are many facets to the laboratory studies employed by PNNL, the four primary objectives of this work are to: identify the type and quantity of contamination present, understand the physical processes that affect the transport of contaminants in the vadose zone sediments, when practical, identify the source(s) of the contamination found in the sediment samples, and when practical, determine if a link can be made between the vadose zone contamination observed and any known groundwater contaminants in the vicinity. Since its inception in 1997, PNNL's Vadose Zone Characterization Project has evolved to better meet these four key objectives. The single-largest adaptation of the Vadose Zone Characterization Project over its ten years of operation was the advent of a tiered sample analysis approach. Use of a tiered approach allows resources to be focused on those samples/tests that provide the largest amount of scientific information to best meet the four key project objectives within the budget available. Another significant, but more recent, adaptation has been the implementation of a rapid turnaround characterization process in which sediment samples are analyzed in near real-time to aid drilling activities within the tank farms. This paper highlights details of the characterization activities performed as well

  17. Deep Vadose Zone Characterization at the Hanford Site: Accomplishments from the Last Ten Years

    SciTech Connect

    Brown, Christopher F.; Serne, R. Jeffrey

    2008-02-28

    The overall goal of the Tank Farm Vadose Zone Project, led by CH2M HILL Hanford Group, Inc., is to define risks from past and future single-shell tank farm activities at Hanford. To meet this goal, CH2M HILL Hanford Group, Inc. tasked scientists from Pacific Northwest National Laboratory (PNNL) to perform detailed analyses on vadose zone sediments collected within/adjacent to the twelve single-shell tank farms contained within Hanford’s Central Plateau region. This work has been performed under the Resource Conservation and Recovery Act (RCRA) Corrective Action Program and is associated with the Hanford Federal Facility Agreement and Consent Order. While there are many facets to the laboratory studies employed by PNNL, the four primary objectives of this work are to: identify the type and quantity of contamination present, understand the physical processes that affect the transport of contaminants in the vadose zone sediments, when practical, identify the source(s) of the contamination found in the sediment samples, and when practical, determine if a link can be made between the vadose zone contamination observed and any known groundwater contaminants in the vicinity. Since its inception in 1997, PNNL’s Vadose Zone Characterization Project has evolved to better meet these four key objectives. The single-largest adaptation of the Vadose Zone Characterization Project over its ten years of operation was the advent of a tiered sample analysis approach. Use of a tiered approach allows resources to be focused on those samples/tests that provide the largest amount of scientific information to best meet the four key project objectives within the budget available. Another significant, but more recent, adaptation has been the implementation of a rapid turnaround characterization process in which sediment samples are analyzed in near real-time to aid drilling activities within the tank farms. This paper highlights details of the characterization activities performed as

  18. A Vision for the Next Ten Years for Integrated Ocean Observing Data

    NASA Astrophysics Data System (ADS)

    Willis, Z. S.

    2012-12-01

    Ocean observing has come a long way since the Ocean Sciences Decadal Committee met over a decade ago. Since then, our use of the ocean and coast and their vast resources has increased substantially - with increased shipping, fishing, offshore energy development and recreational boating. That increased use has also spearheaded advances in observing systems. Cutting-edge autonomous and remotely operated vehicles scour the surface and travel to depths collecting essential biogeochemical data for better managing our marine resources. Satellites enable the global mapping of practically every physical ocean variable imaginable. A nationally-integrated coastal network of high-frequency radars lines the borders of the U.S. feeding critical navigation, response, and environmental information continuously. Federal, academic, and industry communities have joined in unique partnerships at regional, national, and global levels to address common challenges to monitoring our ocean. The 2002 Workshop, Building Consensus: Toward an Integrated and Sustained Ocean Observing System laid the framework for the current United States Integrated Ocean Observing System (U.S. IOOS). Ten years later, U.S. IOOS has moved from concept to reality, though much work remains to meet the nation's ocean observing needs. Today, new research and technologies, evolving users and user requirements, economic and funding challenges, and diverse institutional mandates all influence the future growth and implementation of U.S. IOOS. In light of this new environment, the Interagency Ocean Observation Committee (IOOC) will host the 2012 Integrated Ocean Observing System Summit in November 2012, providing a forum to develop a comprehensive ocean observing vision for the next decade, utilizing the knowledge and expertise gained by the IOOS-wide community over the past ten years. This effort to bring together ocean observing stakeholders at the regional, national, and global levels to address these challenges

  19. Analyzing the study of using acupuncture in delivery in the past ten years in china.

    PubMed

    Chen, Yingru; Zhang, Xuekai; Fang, Yigong; Yang, Jinsheng

    2014-01-01

    The use of acupuncture in inducing delivery has a long history in China. With progress over time, it has been applied in many aspects. For further study of acupuncture in delivery, this paper analyzed the papers using acupuncture in delivery in the past ten years in mainland China. 87 literatures were picked out by searching relevant electronic databases and bibliographies of relevant journals. The analysis showed randomized controlled trials that were the major type of research, while preclinical researches and literature reviews only account for around ten percent, respectively. Clinical researches indicated that acupuncture can relieve labor pain, promote maternal uterine contraction, shorten birth process, and treat postpartum disorders. Preclinical researches found that acupuncture can adjust certain hormones and improve uterus contraction of late-stage pregnant rats. However, due to lack of large multicenter randomized controlled clinical trials, standardized evaluations of clinical effects in clinical researches and detailed mechanism study in preclinical researches and unequivocal conclusions about the effectiveness, efficacy, and mechanisms of acupuncture in this field cannot be obtained from those researches yet. Further clinical and preclinical studies about the use of acupuncture in delivery with improved methodology is still needed. PMID:24688593

  20. Chronic myeloid leukemia relapsing ten years after allogenic bone marrow transplantation.

    PubMed

    Hino, Yutaro; Doki, Noriko; Yamamoto, Keita; Senoo, Yasushi; Sasajima, Satoshi; Sakaguchi, Masahiro; Hattori, Keiichiro; Kaito, Satoshi; Kurosawa, Shuhei; Harada, Kaito; Ikegawa, Shuntaro; Watanabe, Daisuke; Hagino, Takeshi; Yoshioka, Kosuke; Watakabe, Kyoko; Igarashi, Aiko; Najima, Yuho; Kobayashi, Takeshi; Kakihana, Kazuhiko; Sakamaki, Hisashi; Ohashi, Kazuteru

    2016-05-01

    A 58-year-old female was diagnosed with Philadelphia chromosome positive chronic myeloid leukemia (CML) in blast crisis (BC) in 2004. The patient received imatinib, which quickly induced molecular remission, and subsequently underwent bone marrow transplantation (BMT) from an unrelated human leukocyte antigen (HLA)-identical donor. The post-transplant clinical course was essentially uneventful. In 2014, ten years after the BMT, the patient was admitted to our hospital complaining of lymphadenopathy, and blasts were observed in peripheral blood. The patient was diagnosed as having a CML relapse in myeloid BC, with leukemic infiltration in lymph nodes, and was treated with dasatinib. Subsequently, pleural effusion developed and nilotinib was administered, which induced normal blood counts without blasts and partial cytogenetic remission, one month after administration. Six months after the relapse, this patient underwent a second BMT from an HLA-matched unrelated donor. Recent studies have demonstrated the cumulative incidence of CML relapse more than five years after allogeneic hematopoietic stem cell transplantation (allo-HSCT) to be higher than in acute myeloid leukemia. Although rare, the possibility of late relapse should be considered in patients diagnosed with CML after allo-HSCT. PMID:27263786

  1. Trans-Northern Pipelines upgrades ten-year-old SCADA system

    SciTech Connect

    Clarke, D.; West, T.

    1996-02-01

    Trans-Northern Pipelines Inc. (TNPI) recently completed a major upgrade program to modernize its supervisory control and data acquisition (SCADA) system. When compared to the in-place, ten year-old SCADA system, the upgraded system provides enhanced connectivity, safety and efficiency. TNPI`s rationale for installing a new SCADA system was based on a number of economic and other factors. On the cost side, the high upgrade expenses associated with the dated hardware and software of the existing system created a strong justification for replacing the system. Apart from leak detection and batch tracking, a major focus of the upgrade was to consolidate points of measurement on the pipelines for ticketing, billing and EDI transfer to other organizations. TNPI decided at the specification stage that full functionality for each operator at product delivery points and centralized offices was needed. This fully automated an operator`s daily duties, increased accuracy of transportation and communicated valuable SCADA data to the people and processes that would need it. This paper describes the design, performance, and the design making process that went into this system.

  2. Reflection on the Process of Open Sourcing Software Based on Ten Years of Development of RAPID

    NASA Astrophysics Data System (ADS)

    David, C. H.; Famiglietti, J. S.; Yang, Z. L.; Habets, F.; Maidment, D.

    2015-12-01

    As the number and size of geoscience datasets persist in their constant rise, geoscientists increasingly express their yearning for further sharing of their data and software, and for facilitation of the associated academic credits. We present here our experience based on the open source development of an Earth System Model focusing on the propagation of water flow waves in large river networks: the Routing Application for Parallel computatIon of Discharge (RAPID). Since inception of RAPID ten years ago in January 2006, the community of its users has grown slowly but steadily, and now includes researchers in industry, academia, and government organizations. This growth of the RAPID users community can be explained - at least in part - by its open availability. However, despite an increasing support for open science (software and data), the mechanics of sharing still remain mysterious to many geoscientists… as they were for the authors. The purpose of this presentation is therefore to shed light on the steps involved in opening software and data based on a decade of experience related to the development and release of an Earth System Model. Three distinct steps of open sourcing are highlighted here: opening, exposing, and automatic testing. Each one of these steps is presented as an independent and tractable increment at various stages of development that is justified based on the size of the users community. Topics covered include software and data licenses, code and data repositories, unit testing, and continuous integration.

  3. Ten years of publicly funded biological disease-modifying antirheumatic drugs in Australia.

    PubMed

    Hopkins, Ashley M; Proudman, Susanna M; Vitry, Agnes I; Sorich, Michael J; Cleland, Leslie G; Wiese, Michael D

    2016-02-01

    Biological disease-modifying antirheumatic drugs (bDMARDs) for rheumatoid arthritis (RA) treatment were among the first high-cost medicines to be subsidised in Australia. High-cost medicines pose several challenges to the Australian National Medicines Policy, which aims to provide timely access to effective medicines at a cost individuals and the community can afford. Thus, novel restriction criteria were developed to encourage cost-effective use of bDMARDs. Government expenditure on bDMARD subsidies for RA treatment grew to about $383 million in 2014. Evidence that initiation and continuation criteria for bDMARDs meet usually applied cost-benefit criteria is lacking. The combined expenditure on tocilizumab, certolizumab pegol and golimumab (added to the Australian Government's Pharmaceutical Benefits Scheme in 2010) was $93 million in 2014, which is 210% over the initial estimate. Present and future challenges with regard to bDMARDs for RA and other high-cost drugs include improved expenditure predictions, monitoring of cost-effectiveness in relation to actual use and strategic development, regulation and use of biosimilars. Ten years of documentation on clinical and laboratory findings indicating eligibility to initiate and continue on bDMARDs remains un-used. These data represent an untapped opportunity to promote quality of use of bDMARDs and biosimilars and to improve cost predictions for high-cost drugs. PMID:26821102

  4. Naive (commonsense) geography and geobrowser usability after ten years of Google Earth

    NASA Astrophysics Data System (ADS)

    Hamerlinck, J. D.

    2016-04-01

    In 1995, the concept of ‘naive geography’ was formally introduced as an area of cognitive geographic information science representing ‘the body of knowledge that people have about the surrounding geographic world’ and reflecting ‘the way people think and reason about geographic space and time, both consciously and subconsciously’. The need to incorporate such commonsense knowledge and reasoning into design of geospatial technologies was identified but faced challenges in formalizing these relationships and processes in software implementation. Ten years later, the Google Earth geobrowser was released, marking the beginning of a new era of open access to, and application of, geographic data and information in society. Fast-forward to today, and the opportunity presents itself to take stock of twenty years of naive geography and a decade of the ubiquitous virtual globe. This paper introduces an ongoing research effort to explore the integration of naive (or commonsense) geography concepts in the Google Earth geobrowser virtual globe and their possible impact on Google Earth's usability, utility, and usefulness. A multi-phase methodology is described, combining usability reviews and usability testing with use-case scenarios involving the U.S.-Canadian Yellowstone to Yukon Initiative. Initial progress on a usability review combining cognitive walkthroughs and heuristics evaluation is presented.

  5. Functional capacity and rehabilitation of recipients with a functioning renal allograft for ten years or more.

    PubMed

    Flechner, S M; Novick, A C; Braun, W E; Popowniak, K L; Steinmuller, D

    1983-06-01

    Forty-nine renal transplant recipients who had a single functioning allograft for ten or more years are reviewed. There were 17 cadaver recipients and 32 living-related recipients. Most patients have enjoyed excellent long-term renal function with stable mean daily dosages of azathioprine and prednisone. Fifty-three percent of patients never experienced a rejection episode, and 24% of patients experienced only one rejection episode. Five recipients (10%) developed malignancy following transplantation. Based on the Karnofsky activity scale, 80% of patients enjoyed unrestricted activity at ten years posttransplant. The two major factors contributing to declining activity were progression of systemic diseases such as atherosclerosis or diabetes, and declining allograft function. Following transplantation, all patients developed renewed interest in sexual activity, all men were potent, and all women experienced regular menses. Nine men achieved fatherhood and five women underwent successful pregnancy. Currently, 46 recipients are alive with a functioning allograft. These data confirm the ability of recipients with a long-term functioning renal allograft to return to the work force, participate in preillness levels of activity, and enjoy sexual activity and parenthood. PMID:6408771

  6. The Register of Antarctic Marine Species (RAMS): a ten-year appraisal.

    PubMed

    Jossart, Quentin; Moreau, Camille; Agüera, Antonio; Broyer, Claude De; Danis, Bruno

    2015-01-01

    The Register of Antarctic Marine Species (RAMS) is a marine species database that manages an authoritative taxonomic list of species occurring in the Southern Ocean. RAMS links with several other initiatives managing biogeographic or genomics information. The current paper aims to briefly present RAMS and provides an updated snapshot of its contents, in the form of a DarwinCore checklist (available through http://ipt.biodiversity.aq/resource.do?r=rams) and illustrative barplots. Moreover, this article presents a ten year appraisal (since the creation of RAMS). This appraisal first focuses on RAMS bibliometrics. We observed that RAMS was cited (Google Scholar) in 50 distinct publications among which 32 were peer-reviewed in 18 different journals. Three journals (Antarctic Science, Polar Biology, ZooKeys) represent almost 40% of these peer-review publications. The second appraisal focuses on the evolution of new RAMS records. We observed an important decrease in data additions since 2011. As a case study, we focused on an original dataset for a specific group (Asteroidea, Echinodermata). It appears that around one hundred species of asteroids are lacking in RAMS despite the relatively high availability of these data. This suggests that the users' community (or collaborative projects such as AquaRES) could be helpful in order to maintain the RAMS database over the long term. PMID:26478709

  7. Analyzing the Study of Using Acupuncture in Delivery in the Past Ten Years in China

    PubMed Central

    Chen, Yingru; Zhang, Xuekai; Fang, Yigong; Yang, Jinsheng

    2014-01-01

    The use of acupuncture in inducing delivery has a long history in China. With progress over time, it has been applied in many aspects. For further study of acupuncture in delivery, this paper analyzed the papers using acupuncture in delivery in the past ten years in mainland China. 87 literatures were picked out by searching relevant electronic databases and bibliographies of relevant journals. The analysis showed randomized controlled trials that were the major type of research, while preclinical researches and literature reviews only account for around ten percent, respectively. Clinical researches indicated that acupuncture can relieve labor pain, promote maternal uterine contraction, shorten birth process, and treat postpartum disorders. Preclinical researches found that acupuncture can adjust certain hormones and improve uterus contraction of late-stage pregnant rats. However, due to lack of large multicenter randomized controlled clinical trials, standardized evaluations of clinical effects in clinical researches and detailed mechanism study in preclinical researches and unequivocal conclusions about the effectiveness, efficacy, and mechanisms of acupuncture in this field cannot be obtained from those researches yet. Further clinical and preclinical studies about the use of acupuncture in delivery with improved methodology is still needed. PMID:24688593

  8. Ten years of solar power plant operation in the Mojave Desert

    SciTech Connect

    Cohen, G.E.; Frier, S.D.

    1997-12-31

    Nine Solar Electric Generating Systems (SEGS), ranging from 13.8 to 80 MWe of rated name plate capacity, have been operating on a commercial basis in the Mojave desert of southern California since the mid-1980s. Each facility was developed as an Independent Power Producer (IPP) which sells power to the Southern California Edison Company (SCE). The nine SEGS plants provide a combined capacity of 354 MWe, and produce over 90% of the solar electric generation in the world. The SEGS plants utilize large fields of parabolic trough Solar Collector Assemblies (SCAs) supplying thermal energy to produce steam for a Rankine steam turbine/generator cycle. The parabolic trough SCAs have silvered low-iron glass reflectors which focus direct solar radiation on an efficient evacuated receiver, or Heat Collection Element (HCE). After reviewing the technology and plant characteristics, this paper will describe the trends in performance and operating experience over the last ten years. As part of the plant improvements, the paper will also describe the cost-shared program for SEGS III-VII between Sandia National Laboratories and KJC Operating Company (KJC OC). Functioning since 1992, this program is intended to reduce operating and maintenance cost by developing new management methods and technical improvements.

  9. A ten-year study of tick biting in Mississippi: implications for human disease transmission.

    PubMed

    Goddard, Jerome

    2002-01-01

    To determine exactly which tick species bit people in Mississippi, information was gathered on ticks involved in human biting cases for the ten-year period, January 1, 1990-December 31, 1999. Specimens were identified by the author and, in most cases, confirmed by personnel at the Institute of Arthropodology and Parasitology, Georgia Southern University. A total of 119 ticks were recovered from 73 humans during the study period. Seven tick species were represented; most common included the lone star tick, Amblyomma americanum, the gulf coast tick, A. maculatum, the American dog tick, Dermacentor variabilis, and the black-legged deer tick, Ixodes scapularis. Interestingly, no immature Ixodes scapularis were collected. there were several unusual records. Twelve larvae of Amblyomma tuberculatum, a species associated with the gopher tortoise, were removed from a patient. Two Dermacentor albipictus larvae were collected from an elderly woman with no travel history except her backyard. One Dermacentor sp. nymph, removed from a man in central MS, was not even a North American species. One adult female Dermacentor variabilis was involved in a clinical case of tick paralysis. These findings indicate that, although we know which tick species are common human biters, unusual/unreported tick-human interactions may be more common than we think. PMID:12853269

  10. Modeling the Office of Science Ten Year Facilities Plan: The PERI Architecture Team

    SciTech Connect

    de Supinski, Bronis R.; Alam, Sadaf R; Bailey, David; Carrington, Laura; Daley, Christopher; Dubey, Anshu; Gamblin, Todd; Gunter, Dan; Hovland, Paul; Jagode, Heike; Karavanic, Karen; Marin, Gabriel; Mellor-Crummey, John; Moore, Shirley; Norris, Boyana; Oliker, Leonid; Olschanowsky, Cathy; Roth, Philip C; Schulz, Martin; Shende, Sameer; Snavely, Allan; Spea, Wyatt; Tikir, Mustafa; Vetter, Jeffrey S; Worley, Patrick H; Wright, Nicholas

    2009-01-01

    The Performance Engineering Institute (PERI) originally proposed a tiger team activity as a mechanism to target significant effort optimizing key Office of Science applications, a model that was successfully realized with the assistance of two JOULE metric teams. However, the Office of Science requested a new focus beginning in 2008: assistance in forming its ten year facilities plan. To meet this request, PERI formed the Architecture Tiger Team, which is modeling the performance of key science applications on future architectures, with S3D, FLASH and GTC chosen as the first application targets. In this activity, we have measured the performance of these applications on current systems in order to understand their baseline performance and to ensure that our modeling activity focuses on the right versions and inputs of the applications. We have applied a variety of modeling techniques to anticipate the performance of these applications on a range of anticipated systems. While our initial findings predict that Office of Science applications will continue to perform well on future machines from major hardware vendors, we have also encountered several areas in which we must extend our modeling techniques in order to fulfilll our mission accurately and completely. In addition, we anticipate that models of a wider range of applications will reveal critical differences between expected future systems, thus providing guidance for future Office of Science procurement decisions, and will enable DOE applications to exploit machines in future facilities fully.

  11. Modeling the Office of Science Ten Year FacilitiesPlan: The PERI Architecture Tiger Team

    SciTech Connect

    de Supinski, B R; Alam, S R; Bailey, D H; Carrington, L; Daley, C

    2009-05-27

    The Performance Engineering Institute (PERI) originally proposed a tiger team activity as a mechanism to target significant effort to the optimization of key Office of Science applications, a model that was successfully realized with the assistance of two JOULE metric teams. However, the Office of Science requested a new focus beginning in 2008: assistance in forming its ten year facilities plan. To meet this request, PERI formed the Architecture Tiger Team, which is modeling the performance of key science applications on future architectures, with S3D, FLASH and GTC chosen as the first application targets. In this activity, we have measured the performance of these applications on current systems in order to understand their baseline performance and to ensure that our modeling activity focuses on the right versions and inputs of the applications. We have applied a variety of modeling techniques to anticipate the performance of these applications on a range of anticipated systems. While our initial findings predict that Office of Science applications will continue to perform well on future machines from major hardware vendors, we have also encountered several areas in which we must extend our modeling techniques in order to fulfill our mission accurately and completely. In addition, we anticipate that models of a wider range of applications will reveal critical differences between expected future systems, thus providing guidance for future Office of Science procurement decisions, and will enable DOE applications to exploit machines in future facilities fully.

  12. Modeling the Office of Science Ten Year Facilities Plan: The PERI Architecture Tiger Team

    SciTech Connect

    de Supinski, Bronis R.; Alam, Sadaf; Bailey, David H.; Carrington, Laura; Daley, Chris; Dubey, Anshu; Gamblin, Todd; Gunter, Dan; Hovland, Paul D.; Jagode, Heike; Karavanic, Karen; Marin, Gabriel; Mellor-Crummey, John; Moore, Shirley; Norris, Boyana; Oliker, Leonid; Olschanowsky, Catherine; Roth, Philip C.; Schulz, Martin; Shende, Sameer; Snavely, Allan; Spear, Wyatt; Tikir, Mustafa; Vetter, Jeff; Worley, Pat; Wright, Nicholas

    2009-06-26

    The Performance Engineering Institute (PERI) originally proposed a tiger team activity as a mechanism to target significant effort optimizing key Office of Science applications, a model that was successfully realized with the assistance of two JOULE metric teams. However, the Office of Science requested a new focus beginning in 2008: assistance in forming its ten year facilities plan. To meet this request, PERI formed the Architecture Tiger Team, which is modeling the performance of key science applications on future architectures, with S3D, FLASH and GTC chosen as the first application targets. In this activity, we have measured the performance of these applications on current systems in order to understand their baseline performance and to ensure that our modeling activity focuses on the right versions and inputs of the applications. We have applied a variety of modeling techniques to anticipate the performance of these applications on a range of anticipated systems. While our initial findings predict that Office of Science applications will continue to perform well on future machines from major hardware vendors, we have also encountered several areas in which we must extend our modeling techniques in order to fulfill our mission accurately and completely. In addition, we anticipate that models of a wider range of applications will reveal critical differences between expected future systems, thus providing guidance for future Office of Science procurement decisions, and will enable DOE applications to exploit machines in future facilities fully.

  13. The Register of Antarctic Marine Species (RAMS): a ten-year appraisal

    PubMed Central

    Jossart, Quentin; Moreau, Camille; Agüera, Antonio; Broyer, Claude De; Danis, Bruno

    2015-01-01

    Abstract The Register of Antarctic Marine Species (RAMS) is a marine species database that manages an authoritative taxonomic list of species occurring in the Southern Ocean. RAMS links with several other initiatives managing biogeographic or genomics information. The current paper aims to briefly present RAMS and provides an updated snapshot of its contents, in the form of a DarwinCore checklist (available through http://ipt.biodiversity.aq/resource.do?r=rams) and illustrative barplots. Moreover, this article presents a ten year appraisal (since the creation of RAMS). This appraisal first focuses on RAMS bibliometrics. We observed that RAMS was cited (Google Scholar) in 50 distinct publications among which 32 were peer-reviewed in 18 different journals. Three journals (Antarctic Science, Polar Biology, ZooKeys) represent almost 40% of these peer-review publications. The second appraisal focuses on the evolution of new RAMS records. We observed an important decrease in data additions since 2011. As a case study, we focused on an original dataset for a specific group (Asteroidea, Echinodermata). It appears that around one hundred species of asteroids are lacking in RAMS despite the relatively high availability of these data. This suggests that the users’ community (or collaborative projects such as AquaRES) could be helpful in order to maintain the RAMS database over the long term. PMID:26478709

  14. Highlighting ten years of physics education research in the upper division

    NASA Astrophysics Data System (ADS)

    Ambrose, Bradley

    2015-04-01

    The field of Physics Education Research (PER) has for over thirty years provided insights into student thinking and guided the development and assessment of reformed teaching strategies and practices in introductory physics courses. In the last decade or so, researchers have expanded the domain of such investigations to upper-division courses where undergraduate majors study more advanced content and begin to see themselves as future physicists. The upcoming Focused Collection on Upper Division PER brings together work from researchers active in these new frontiers of PER. In this presentation we provide an overview of the studies in this collection, which offer to the PER and greater physics education communities: new insights about the thinking, behavior, and beliefs of students in the upper division; new tools to innovate instruction, assess student learning, and evaluate teaching effectiveness; and groundbreaking studies of identity development and ``thinking like a physicist'' among physics majors. In this session we also recognize the ten-year anniversary of Physical Review Special Topics: Physics Education Research, an occasion that we will celebrate with an informal reception immediately following the conclusion of this invited session.

  15. Dermatofibrosarcoma protuberans: our experience after ten years of patient's surgical follow-up.

    PubMed

    Bervar, M

    2003-01-01

    Dermatofibrosarcoma protuberans has a high rate of recurrence, presumably as a consequence of persistent residual tumour. This is probably the main reason why repeated surgical treatment is frequently required. In the article we present our experience of surgical treatment of such malignancy on the neck and shoulder in the elder male after ten years follow-up period. The case is interesting because we started with aggressive treatment relatively late in the unfavourable, fully-developed stage of the disease, with multiple satellite nodules spreading and signs of partial myxoid degeneration of the largest tumour mass itself. Despite initial wide excision, five local recurrences--fortunately without regional or distant metastases--were observed during the first eight years. The recurrences appeared mostly in the region of greatest tumour degeneration and infiltration and where the excision margins were less than 2 cm apart from the visible tumour mass. A sufficiently wide excision, long-term follow-up and good co-operation between surgeon and experienced pathologist are crucial for the strategy of treatment and the prognosis of this unusual malignancy. PMID:12921258

  16. SPIE Smart Structures Product Implementation Award: a review of the first ten years

    NASA Astrophysics Data System (ADS)

    Anderson, Eric H.; Sater, Janet M.

    2007-04-01

    The research field of smart materials and structures has been a distinct entity for two decades. Over the past ten years, the SPIE Industrial and Commercial Applications Conference has presented a Smart Structures Product Implementation Award at its annual symposium. This paper revisits the nine winning entries to date (1998-2007) and updates their status. The paper begins with a brief description of the original and current intent of the award and follows with a short overview of the evolution of smart structures, from research to products. The winning teams and their respective products are then described. The current status of the products is discussed based on publicly available information and input from the respective companies. Note however that it is not the purpose of the paper to rank the product winners in terms of success or sales. The paper concludes with an assessment of the larger trends in productization of smart structures technologies. The application "form" for the award as well as the evaluation criteria and suggestions for improving award application packages can be found in the appendix.

  17. Alumina-on-alumina total hip arthroplasty: a concise follow-up, at a minimum of ten years, of a previous report.

    PubMed

    Lee, Young-Kyun; Ha, Yong-Chan; Yoo, Jeong Joon; Koo, Kyung-Hoi; Yoon, Kang Sup; Kim, Hee Joong

    2010-07-21

    We previously reported the five-to-six-year results of the use of third-generation alumina-on-alumina bearings in a consecutive series of 100 primary cementless total hip arthroplasties. This report presents the longer-term outcomes of these same bearings, at a minimum of ten years postoperatively. Eighty-six of eighty-eight hips available for the study retained the original bearings at the time of the latest follow-up. Thirteen hips were associated with noise, and six hips demonstrated fretting of the femoral neck on radiographs. Two hips required a change of the bearings because of a ceramic head fracture. The ten-year survival rate of the alumina-on-alumina total hip prostheses, with revision of any implant for any reason as the end point, was 99.0%. On the basis of those results, we concluded that the rate of survival of primary cementless total hip prostheses with third-generation alumina-on-alumina bearings is excellent at ten years. However, the risk of ceramic fracture, noise, and impingement between the metal neck and the ceramic liner should be a concern to surgeons, and patients should be informed of these risks before surgery. PMID:20660234

  18. 1994-2004 : Ten years of European effort for education in Seismology

    NASA Astrophysics Data System (ADS)

    Virieux, J.; Zollo, A.; Lomax, A.; Berenguer, J.; Laj, C.; Bobbio, A.

    2004-12-01

    Following trends of the pioneer PEPP project in USA, an European group has investigated since 1994 how to promote physics and earth sciences and, more specifically, how to educate scientifically and socially young generations to environmental hazards. Seismology has been selected as the vehicle for a prototypical ten-years experience of teaching and learning sciences in European high schools accounting for the specificity and differencies of educational systems in each country. This general purpose has required competences and strong interactions of both teachers, researchers and high school students. Over ten years of continuous activities, these people have found that the target was very ambitious and that both high-tech efforts as well as very focused teaching procedures must be set on. Dedicated instruments were developped in two years through interactions between researchers,teachers and students in order to fit both the scientific quality but also pedagogical features and were installed in different parts of Europe. The sequence of Colfiorito Earthquakes in September-October 1997 was the first data collected simultaneously in different European schools. Since then, more thant 50 stations have been deployed over Europe and data have been made available for education purposes. Data from these seismic stations have been used as the back-bone for interactions between students/pupils, teachers and researchers leading to the development of dedicated teaching and learning materials as software tools for data analysis, simple experimentations and so on. The framework for such an European initiative has been provided by Italian and French national funds and put together under the banner of the so-called EDUSEIS projet. This EDUcational SEISmological European Network (http://www.eduseis.org/) has shown that indeed environmental education is possible with its typical feature of long-term efforts. Funding through Europe will certainly increase the cohesion of this

  19. A ten-year water balance of a mountainous semi-arid watershed

    NASA Astrophysics Data System (ADS)

    Flerchinger, G. N.; Cooley, K. R.

    2000-10-01

    Quantifying water balance components, which is particularly challenging in snow-fed, semi-arid regions, is crucial to understanding the basic hydrology of a watershed. In this study, a water balance was computed using 10 years of data collected at the Upper Sheep Creek Watershed, a 26-ha semi-arid mountainous sub-basin within the Reynolds Creek Experimental Watershed in southwest Idaho, USA. The approach computed a partial water balance for each of three landscape units and then computed an aggregated water balance for the watershed. Runoff and change in ground water storage were not distinguishable between landscape units. Precipitation, which occurs predominantly as snow, was measured within each landscape unit directly and adjusted for drifting. Spatial variability of effective precipitation was shown to be greater during years with higher precipitation. Evapotranspiration, which accounted for nearly 90% of the effective precipitation, was estimated using the Simultaneous Heat and Water (SHAW) Model and validated with measurements from Bowen ratio instruments. Runoff from the watershed was correlated to precipitation above a critical threshold of approximately 450 mm of precipitation necessary to generate runoff ( r2=0.52). The average water balance error was 46 mm, or approximately 10% of the estimated effective precipitation for the ten-year period. The error was largely attributed to deep percolation losses through fractures in the basalt underlying the watershed. Simulated percolation of the water beyond the root zone correlated extremely well with measured runoff ( r2=0.90), which is derived almost entirely from subsurface flow. Above a threshold of 50 mm, approximately 67% of the water percolating beyond the root zone produces runoff. The remainder was assumed to be lost to deep percolation through the basalt. This can have important ramifications in addressing subsurface flow and losses when applying a snowmelt runoff model to simulate runoff and

  20. Clinical characteristics of renal cancer in Malaysia : a ten year review.

    PubMed

    Singam, Praveen; Ho, Christopher; Hong, Goh Eng; Mohd, Azrif; Tamil, Azmi Md; Cheok, Lee Boon; Zainuddin, Zulkifli

    2010-01-01

    Renal cancer is rare and its incidence is 1.9 per 100,000 in the Malaysian population, which consists of three major ethnic groups (Malay, Chinese and Indians). A retrospective study was her conducted to identify clinical characteristics and ethnic background influences on presentation. The study included all renal cancer patients from a single medical institution over ten years, with a total of 75 cases. Seventy-three patients underwent surgery while 2 received only radiotherapy or chemotherapy. The male to female ratio was 2.75:1. Incidence was equal among the Malay (49.3%) and Chinese ethnic groups (45.3%). Mean age of patients were 57.1 (18-93) years old. There were 26 (37.4%) patients with Stage I disease, 14 (18.7%) at Stage II, 23 (30.7%) at Stage III and 12 (16%) at Stage IV. The Chinese race presented at mean older age (p= 0.02) and later stage of disease (p= 0.046). Patients above 40 years old had more advanced stage disease (p= 0.023). Tumour histology were clear cell (72%), urothelial cell (13.3%), sarcomatoid cell and nephroblastoma each contributed 2.7%. The mean tumour size was 8.1 (2-20) cm. There was substantial agreement between the pre and post operative staging (kappa 0.691). In conclusion we observed significant influences of age and race in the clinical presentation of renal cancer in our institution based population. There was larger male to female ratio and mean tumour size as compared to previous epidemiology studies. PMID:20843141

  1. Analysis of Comorbidity of the Patients Affected by Staphylococcal Bacteremia/Sepsis in the Last Ten Years

    PubMed Central

    Lukovac, Enra; Koluder-Cimic, Nada; Hadzovic-Cengic, Meliha; Baljic, Rusmir; Hadzic, Amir; Gojak, Refet

    2012-01-01

    SUMMARY CONFLICT OF INTEREST: none declared. Introduction Staphylococcal bacteremia/sepsis is one of the most serious bacterial infections around the world. In individuals with pre-existing diseases, there is always an increased risk of infections occurring due to impaired immune system, a variety of drug therapy, exposure to a diagnostic and therapeutic procedure and frequent hospitalizations. Objectives To analyze the prevalence of comorbidity in a patient with the staphylococcal bacteremia/sepsis according to the diagnosis, the site of infection and according to the isolated agent. Patients and methods We analyzed the patients affected by the staphylococcal bacteremia/sepsis and treated in the Clinic for Infectious Diseases during a ten-year period. Results 87 patients were included, out of whom 20 (23%) with clinical signs of the bacteremia and 67 (77%) of sepsis. In the analyzed sample, in 36 (41.4%) were not registered comorbidity. Hospital infections are represented by the previous antibiotic, corticosteroid and chemo therapy, pressure ulcers, and different implants. In all comorbidity, the most common isolated bacteria was S. aureus primarily strain MSSA followed by MRSA strain which is more frequent in patients who were surgically treated (comorbidity–various implants). Conclusion The results suggest the importance of being mindful of the staphylococcal etiology of the bacteremia/sepsis in patients with comorbidities due to the selection of an adequate initial empirical therapy and reducing the risks of the septic shock. PMID:24493989

  2. Ten years water and energy surface balance from the CNR-ISAC micrometeorological station in Salento peninsula (southern Italy)

    NASA Astrophysics Data System (ADS)

    Martano, P.; Elefante, C.; Grasso, F.

    2015-06-01

    Data of surface-atmosphere energy and water transfer from a ten years (2003-2013) period of activity of the ISAC-Lecce micrometeorological station (http://www.basesperimentale.le.isac.cnr.it) have been analyzed: to the authors' knowledge this is the first decadal data set of surface-atmosphere transfer in Salento peninsula. The surface energy budget shows a tendency to a positive bias possibly due to several reasons that require more investigations. Some suitable indices related to the surface water balance, such as the precipitation intensity, the aridity index and the ground water infiltration fraction have been calculated. Possible trends of these annual averages in the decadal period are considered, also taking into account the statistical uncertainty associated to measurement errors and missing data. The results indicate a significant increasing in the precipitation intensity together with an experimental evidence of increasing of the ground water infiltration in the measurement area, that is in agreement with recent estimations for the whole Salento peninsula. On the other hand, recent studies show that seawater intrusion and salinization of the deep underground aquifer keep increasing in the same period.

  3. Saturn’s Tropospheric Temperatures and Para-Hydrogen Distribution from Ten Years of Cassini Observations

    NASA Astrophysics Data System (ADS)

    Fletcher, Leigh N.; Irwin, Patrick G.; Sinclair, James; Giles, Rohini; Barstow, Joanna; Achterberg, Richard K.; Orton, Glenn S.

    2014-11-01

    Cassini/CIRS observations of Saturn’s 10-1400 cm-1 spectrum have been inverted to construct a global record of tropospheric temperature and para-hydrogen variability over the ten-year span of the Cassini mission. The data record the slow reversal of seasonal asymmetries in tropospheric conditions from northern winter (2004, Ls=293), through northern spring equinox (2009, Ls=0) to the present day (2014, Ls=60). Mid-latitude tropospheric temperatures have cooled by approximately 4-6 K in the south and warmed by 2-4 K in the north, with the seasonal contrast decreasing with depth. CIRS detected the north polar minimum 100-mbar temperatures 6-8 years after winter solstice, whereas the south polar maximum occurred 1-2 years after summer solstice, consistent with the lag times predicted by radiative equilibrium models. Warm polar cyclones and the northern hexagon persist throughout the mission, suggesting that they are permanent features of Saturn’s tropospheric circulation. The 200-mbar thermal enhancement (“knee”) that was strongest in the summer but weak or absent in winter in 2004-2006 (Fletcher et al., 2007, Icarus 189, p.457-478) has now shifted northward and is present globally in 2014, suggestive of radiative heating in Saturn’s tropospheric haze layer. Saturn’s para-H2 fraction, which serves as a tracer of both tropospheric mixing and the efficiency of re-equilibration between the ortho- and para-hydrogen states, is slowly altering: super-equilibrium conditions (para-H2 fraction exceeding equilibrium expectations and suggestive of subsiding airmasses) that dominated the southern summer hemisphere are now weakening, whereas the sub-equilibrium conditions (suggestive of uplift) of the northern winter are being replaced by equilibrium or super-equilibrium conditions in spring. The thermal ‘knee’ and the para-H2 distribution are tracking both the increased spring illumination and the increasing tropospheric haze opacity of the springtime hemisphere

  4. [Good agricultural practice (GAP) of Chinese materia medica (CMM) for ten years: achievements, problems and proposals].

    PubMed

    Guo, Lan-Ping; Zhang, Yan; Zhu, Shou-Dong; Wang, Gui-Hua; Wang, Xiu; Zhang, Xiao-Bo; Chen, Mei-Lan; He, Ya-Li; Han, Bang-Xing; Chen, Nai-Fu; Huang, Lu-Qi

    2014-04-01

    This paper aims to summarize the achievements during the implementation process of good agricultural practice (GAP) in Chinese Materia Medica (CMM), and on basis of analyzing the existing problems of GAP, to propose further implementation of GAP in TCM growing. Since the launch of GAP in CMM growing ten years ago, it has acquired great achievements, including: (1) The promulgation of a series of measures for the administration of the GAP approval in the CMM growing; (2) The expanded planting area of CMM; (3) The increased awareness of standardized CMM growing among farmers and enterprises; (4) The establishment of GAP implementation bases for CMM growing; (5) The improvement of theory and methodology for CMM growing; (6) The development of a large group of experts and scholars in GAP approval for CMM production. The problems existing in the production include: (1) A deep understanding of GAP and its certification is still needed; (2) The distribution of the certification base is not reasonable; (3) The geo-economics effect and the backward farming practices are thought to be the bottlenecks in the standardization of CMM growing and the scale production of CMM; (4) Low comparative effectiveness limits the development of the GAP; (5) The base of breeding improved variety is blank; (6) The immature of the cultivation technique lead to the risk of production process; (7) The degradation of soil microbial and the continuous cropping obstacle restrict the sustainable development of the GAP base. To further promote the health and orderly GAP in the CMM growing, the authors propose: (1) To change the mode of production; (2) To establish a sound standard system so as to ensure quality products for fair prices; (3) To fully consider the geo-economic culture and vigorously promote the definite cultivating of traditional Chinese medicinal materials; (4) To strengthen the transformation and generalization of basic researches and achievements, in order to provide technical

  5. Offsite source recovery project - ten years of sealed source recovery and disposal

    SciTech Connect

    Whitworth, Julia Rose; Pearson, Mike; Witkowski, Ioana; Wald - Hopkins, Mark; Cuthbertson, A

    2010-01-01

    The Global Threat Reduction Initiative's (GTRI) Offsite Source Recovery Project (OSRP) has been recovering excess and unwanted radioactive sealed sources for ten years. In January 2009, GTRI announced that the project had recovered 20,000 sealed radioactive sources (this number has since increased to more than 23,000). This project grew out of early efforts at Los Alamos National Laboratory (LANL) to recover and disposition excess Plutonium-239 (Pu-239) sealed sources that were distributed in the 1960s and 1970s under the Atoms for Peace Program. Decades later, these sources began to exceed their special form certifications or fall out of regular use. As OSRP has collected and stored sealed sources, initially using 'No Path Forward' waste exemptions for storage within the Department of Energy (DOE) complex, it has consistently worked to create disposal pathways for the material it has recovered. The project was initially restricted to recovering sealed sources that would meet the definition of Greater-than-Class-C (GTCC) low-level radioactive waste, assisting DOE in meeting its obligations under the Low-level Radioactive Waste Policy Act Amendments (PL 99-240) to provide disposal for this type of waste. After being transferred from DOE-Environmental Management (EM) to the U.S. National Nuclear Security Administration (NNSA) to be part of GTRI, OSRP's mission was expanded to include not only material that would be classified as GTCC when it became waste, but also any other materials that might constitute a 'national security consideration.' It was recognized at the time that the GTCC category was a waste designation having to do with environmental consequence, rather than the threat posed by deliberate or accidental misuse. The project faces barriers to recovery in many areas, but disposal continues to be one of the more difficult to overcome. This paper discusses OSRP's disposal efforts over its 10-year history. For sources meeting the DOE definition of

  6. Creative Climate: A global ten-year communications, research and learning project about environmental change

    NASA Astrophysics Data System (ADS)

    Brandon, M. A.; Smith, J.

    2010-12-01

    The next ten years have been described by influential science and policy figures as ‘the most important in human history’. Many believe that the actions taken will decide whether we catastrophically change the atmosphere and eradicate our fellow species or find an alternative, less-damaging development path. But communications and public engagement initiatives have tended to focus on near term impacts or debates - whether they emphasise hazards, or trumpet ‘solutions’. There are signs of diminishing returns on communications and public engagement efforts, and serious obstacles to engaging around 40% of publics in e.g. the US and the UK. The Creative Climate web project takes a new approach, inviting people to see humanity’s intellectual and practical journey with these issues as an inspiring, dynamic and unfolding story. We are inviting people to join us in building a huge living archive of experiences and ideas that respond to these issues. The website will collect thoughts and stories from doorstep to workplace, from lab to garden; from international conference to community meeting - from all over the world. The body of diaries lie at the core of the project, but these are supplemented by the offer of free online learning resources and broadcast-quality audio and video materials. The project is experimental in terms of its scope, its approach to environmental communications and debate and in its use of media. It works with formal partners, including the BBC, yet also makes the most of the opportunities for user generated content to create a rich multimedia resource that can support research, learning and engagement. The design of the project is informed by environmental social science and communications research, and by an awareness of the unfolding potential of Internet based communications to support social change. It is also intended that the Creative Climate platform will develop so as to serve researchers by offering an open resource of qualitative

  7. Negotiating with Development Partners: Ten-Year Plan for the Development of Basic Education in Burkina Faso

    ERIC Educational Resources Information Center

    Ki, Bourema Jacques; Ouedraogo, Louis-Honore; Luisoni, Pierre

    2006-01-01

    This article discusses the ten-year plan for the development of basic education in Burkina Faso. Burkina Faso has to meet a major challenge, which consists of reducing poverty among the population, reducing exposure to crises of all kinds, and reducing inequality between regions and between different socio-economic sectors. In order to achieve…

  8. A Study in Critical Listening Using Eight to Ten Year Olds in an Analysis of Commercial Propaganda Emanating from Television.

    ERIC Educational Resources Information Center

    Cook, Jimmie Ellis

    Selected eight to ten year old Maryland children were used in this study measuring the effect of lessons in becoming aware of propaganda employed by commercial advertisers in television programs. Sixteen 45-minute lessons directed to the propaganda techniques of Band Wagon, Card Stacking, Glittering Generalities, Name Calling, Plain Folks,…

  9. 78 FR 56185 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ... From the Federal Register Online via the Government Publishing Office ] ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year Carbon Monoxide Maintenance Plan for Fort Collins AGENCY: Environmental Protection...

  10. 78 FR 46861 - Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-02

    ... From the Federal Register Online via the Government Publishing Office ENVIRONMENTAL PROTECTION AGENCY 40 CFR Part 52 Approval and Promulgation of Air Quality Implementation Plans; State of Colorado; Second Ten-Year Carbon Monoxide Maintenance Plan for Greeley AGENCY: Environmental Protection Agency...

  11. Ten Years of Youth Programs at the American Museum of Natural History: An Independent Perspective and Lessons Learned

    ERIC Educational Resources Information Center

    Carroll, Becky

    2008-01-01

    In this report, the author shares her perspective on ten years of science-rich programming for high school youth at the American Museum of Natural History. This report includes: (1) A discussion of the theory of action and the rationale that underlies the AMNH youth programs; (2) A description of three of the programs that have been offered and…

  12. Organisation and Management of a Complete Bachelor Degree Offered Online at the University of Milan for Ten Years

    ERIC Educational Resources Information Center

    Milani, Manuela; Papini, Sabrina; Scaccia, Daniela; Scarabottolo, Nello

    2014-01-01

    This paper is aimed at presenting some reflections on organisation and management of SSRI online: an e-learning initiative started at the University of Milan (Italy) in the academic year 2004/05 and offered to students over the last ten years. The initiative consisted in implementing the online version of an already existing three-year bachelor…

  13. Ten-Year Comparisons of Problems and Competencies for National Samples of Youth: Self, Parent, and Teacher Reports.

    ERIC Educational Resources Information Center

    Achenbach, Thomas M.; Dumenci, Levent; Rescorla, Leslie A.

    2002-01-01

    This study compared national samples of United States' 11- to 18- year-olds assessed in 1989 and 1999. Parent, teacher and self-report sources showed small improvements in competencies and adaptive functioning and small declines in problems over ten years. No significant differences on any scales were found for youths assessed shortly before and…

  14. Germline mutation in BRCA1 or BRCA2 and ten-year survival for women diagnosed with epithelial ovarian cancer

    PubMed Central

    Candido-dos-Reis, Francisco J.; Song, Honglin; Goode, Ellen L.; Cunningham, Julie M.; Fridley, Brooke L.; Larson, Melissa C.; Alsop, Kathryn; Dicks, Ed; Harrington, Patricia; Ramus, Susan J.; de Fazio, Anna; Mitchell, Gillian; Fereday, Sian; Bolton, Kelly L.; Gourley, Charlie; Michie, Caroline; Karlan, Beth; Lester, Jenny; Walsh, Christine; Cass, Ilana; Olsson, Håkan; Gore, Martin; Benitez, Javier J.; Garcia, Maria J.; Andrulis, Irene; Mulligan, Anna Marie; Glendon, Gord; Blanco, Ignacio; Lazaro, Conxi; Whittemore, Alice S.; McGuire, Valerie; Sieh, Weiva; Montagna, Marco; Alducci, Elisa; Sadetzki, Siegal; Chetrit, Angela; Kwong, Ava; Kjaer, Susanne K.; Jensen, Allan; Høgdall, Estrid; Neuhausen, Susan; Nussbaum, Robert; Daly, Mary; Greene, Mark H.; Mai, Phuong L.; Loud, Jennifer T.; Moysich, Kirsten; Toland, Amanda E.; Lambrechts, Diether; Ellis, Steve; Frost, Debra; Brenton, James D.; Tischkowitz, Marc; Easton, Douglas F.; Antoniou, Antonis; Chenevix-Trench, Georgia; Gayther, Simon A.; Bowtell, David; Pharoah, Paul D. P.

    2014-01-01

    Purpose To analyse the effect of germline mutations in BRCA1 and BRCA2 on mortality in ovarian cancer patients up to ten years after diagnosis. Experimental Design We used unpublished survival time data for 2,242 patients from two case-control studies and extended survival-time data for 4,314 patients from previously reported studies. All participants had been screened for deleterious germline mutations in BRCA1 and BRCA2. Survival time was analysed for the combined data using Cox proportional hazard models with BRCA1 and BRCA2 as time-varying covariates. Competing risks were analysed using Fine and Gray model. Results The combined 10-year overall survival was 30% (95% CI, 28%-31%) for non-carriers, 25% (95% CI, 22%-28%) for BRCA1 carriers, and 35% (95% CI, 30%-41%) for BRCA2 carriers. The hazard ratio for BRCA1 was 0.53 at time zero and increased over time becoming greater than one at ·4.8 years. For BRCA2, the hazard ratio was 0.42 at time zero and increased over time (predicted to become greater than one at 10.5 years). The results were similar when restricted to 3,202 patients with high-grade serous tumors, and to ovarian cancer specific mortality. Conclusions BRCA1/2 mutations are associated with better short-term survival, but this advantage decreases over time and, in BRCA1 carriers is eventually reversed. This may have important implications for therapy of both primary and relapsed disease and for analysis of long-term survival in clinical trials of new agents, particularly those that are effective in BRCA1/2 mutation carriers. PMID:25398451

  15. Clinical presentation and treatment outcome of molar pregnancy: Ten years experience at a Tertiary Care Hospital in Dammam, Saudi Arabia

    PubMed Central

    Al-Talib, Ayman A.

    2016-01-01

    Objectives: To study the clinical presentation and treatment outcome of molar pregnancy at a Tertiary Care Hospital in Dammam, Saudi Arabia. Materials and Methods: Reviewed medical records of all molar pregnancy cases among all the deliveries at a tertiary care hospital in Dammam from 2005 to 2014, after approval by institutional ethical review committee. Data abstracted included patient's age, parity, presenting symptoms, gestational age at diagnosis, uterine size, ultrasonographic findings, BhCG level at the time of diagnosis and at follow-up after evacuation, and blood loss during evacuation. Data was entered and analyzed using Excel; frequency distribution for categorical variables and descriptive statistics for continuous variables were computed. Results: Of a total of 25,000 deliveries in ten years, 22 cases of complete molar pregnancy were encountered: 0.9 cases of molar pregnancy per 1000 pregnancies. Majority of patients (63.7%) were older than 35 years, and were nulliparous (45.5%). The commonest symptom was vaginal bleeding (86.4%) followed by hyperemesis gravidarum (41.0%); Hyperthyroidism was seen in 1 patient (4.5%). Ovarian enlargement by theca-lutin cyst was seen in 3 patients (13.6%). The majority of patients (63.6%) had normal BhCG within 9 weeks (63 days) after suction curettage. The majority of the cases followed a benign course. Conclusion: Aged older than 35 years seems a risk factor and vaginal bleeding is the commonest presenting symptom. Early booking of pregnant women to antenatal care clinics and routine first trimester ultrasound made diagnosis easier and earlier before complications appear. PMID:27625583

  16. Ten-year fatal and non-fatal myocardial infarction incidence in elderly populations in Spain: the EPICARDIAN cohort study

    PubMed Central

    Gabriel, Rafael; Alonso, Margarita; Reviriego, Blanca; Muñiz, Javier; Vega, Saturio; López, Isidro; Novella, Blanca; Suárez, Carmen; Rodríguez-Salvanés, Francisco

    2009-01-01

    Background In Spain, more than 85% of coronary heart disease deaths occur in adults older than 65 years. However, coronary heart disease incidence and mortality in the Spanish elderly have been poorly described. The aim of this study is to estimate the ten-year incidence and mortality rates of myocardial infarction in a population-based large cohort of Spanish elders. Methods A population-based cohort of 3729 people older than 64 years old, free of previous myocardial infarction, was established in 1995 in three geographical areas of Spain. Any case of fatal and non-fatal myocardial infarction was investigated until December 2004 using the "cold pursuit method", previously used and validated by the the WHO-MONICA project. Results Men showed a significantly (p < 0.001) higher cumulative incidence of myocardial infarction (7.2%; 95%CI: 5.94-8.54) than women (3.8%; 95%CI: 3.06-4.74). Although cumulative incidence increased with age (p < 0.05), gender-differences tended to narrow. Adjusted incidence rates were higher in men (957 per 100 000 person-years) than in women (546 per 100 000 person-years) (p < 0.001) and increased with age (p < 0.001). The increase was progressive in women but not in men. Adjusted mortality rates were also higher in men than in women (p < 0.001), being three times higher in the age group of ≥ 85 years old than in the age group of 65-74 years old (p < 0.001). Conclusion Incidence of fatal and non-fatal myocardial infarction is high in the Spanish elderly population. Men show higher rates than women, but gender differences diminish with age. PMID:19778417

  17. A ten-year global record of absorbing aerosols above clouds from OMI's near-UV observations

    NASA Astrophysics Data System (ADS)

    Jethva, Hiren; Torrres, Omar; Ahn, Changwoo

    2016-05-01

    Aerosol-cloud interaction continues to be one of the leading uncertain components of climate models, primarily due to the lack of an adequate knowledge of the complex microphysical and radiative processes associated with the aerosolcloud system. The situations when aerosols and clouds are found in the same atmospheric column, for instance, when light-absorbing aerosols such as biomass burning generated carbonaceous particles or wind-blown dust overlay low-level cloud decks, are commonly found over several regional of the world. Contrary to the cloud-free scenario over dark surface, for which aerosols are known to produce a net cooling effect (negative radiative forcing) on climate, the overlapping situation of absorbing aerosols over cloud can potentially exert a significant level of atmospheric absorption and produces a positive radiative forcing at top-of-atmosphere. The magnitude of direct radiative effects of aerosols above cloud depends directly on the aerosol loading, microphysical-optical properties of the aerosol layer and the underlying cloud deck, and geometric cloud fraction. We help in addressing this problem by introducing a novel product of optical depth of absorbing aerosols above clouds retrieved from near-UV observations made by the Ozone Monitoring Instrument (OMI) on board NASA's Aura platform. The presence of absorbing aerosols above cloud reduces the upwelling radiation reflected by cloud and produces a strong `color ratio' effect in the near-UV region, which can be unambiguously detected in the OMI measurements. Physically based on this effect, the OMACA algorithm retrieves the optical depths of aerosols and clouds simultaneously under a prescribed state of atmosphere. The algorithm architecture and results from a ten-year global record including global climatology of frequency of occurrence and above-cloud aerosol optical depth, and a discussion on related future field campaigns are presented.

  18. Monitoring of Pb Exposure in Waterfowl Ten Years after a Mine Spill through the Use of Noninvasive Sampling

    PubMed Central

    Martinez-Haro, Monica; Taggart, Mark A.; Lefranc, Hugues; Martín-Doimeadiós, Rosa C.; Green, Andy J.; Mateo, Rafael

    2013-01-01

    Lead exposure in waterfowl was studied using noninvasive fecal sampling in the Guadalquivir Marshes in Spain, an area affected by the 1998 Aznalcóllar mine disaster. Feces of greylag geese (Anser anser, n = 191) and purple gallinule (Porphyrio porphyrio, n = 91) were collected from three different impacted sites (Entremuros, Caracoles and Cerro de los Ánsares) during the winters of 2004 to 2008. Lead and aluminium (an indicator of sediment ingestion) and Pb isotope signatures (to discriminate between sources of Pb exposure) were analyzed in freeze-dried, acid digested samples. The concentrations of fecal porphyrins and biliverdin were determined as noninvasive biomarkers to study Pb exposure effects. Results showed a decrease in Pb exposure over time in wintering greylag geese. In contrast, for purple gallinule resident in the Entremuros a clear trend was not evident. For both species, sediment ingestion appeared to be the main source of exposure to Pb. In the Entremuros, some samples from purple gallinule were detected with higher Pb levels than expected for simple soil ingestion, and these had Pb isotopic profiles compatible with mining sludge or Pb shot. Whilst fecal Pb isotopic profiles were effective in differentiating between samples from sites with different levels and sources of pollution, the combined use of element ratios (such as Pb/Al) and other non-traditional stable isotope signatures may also prove worthwhile. Overall, the fecal Pb levels detected were below those described in feces for waterfowl from other uncontaminated areas(<10 µg/g d.w.). Despite this, for both species fecal Pb levels were positively correlated with porphyrin excretion, and for purple gallinule, with the coproporphyrin III/I ratio, suggesting some subtle effects on heme synthesis in birds. Ten years after the mine spill, Pb contamination in birds by this pollution source was still detectable and subtlethal effects may persist. PMID:23437364

  19. Ten-Year Effects of the ACTIVE Cognitive Training Trial on Cognition and Everyday Functioning in Older Adults

    PubMed Central

    Rebok, George W.; Ball, Karlene; Guey, Lin T.; Jones, Richard N.; Kim, Hae-Young; King, Jonathan W.; Marsiske, Michael; Morris, John N.; Tennstedt, Sharon L.; Unverzagt, Frederick W.; Willis, Sherry L.

    2013-01-01

    Objective To determine the effects of cognitive training on cognitive abilities and everyday function over 10 years. Design, Setting, and Participants Ten-year follow-up of a randomized, controlled single-blind trial with 3 intervention groups and a no-contact control group. A volunteer sample of 2832 persons (mean baseline age, 73.6 years; 26% African American) living independently in 6 US cities. Interventions Ten-session training for memory, reasoning, or speed-of-processing.; 4-session booster training at 11 and at 35 months after training. Measurements Objectively measured cognitive abilities and self-reported and performance-based measures of everyday function. Results Participants in each intervention group reported less difficulty with instrumental activities of daily living (IADL) (memory: effect size, 0.48 [99% CI, 0.12-0.84]; reasoning: effect size, 0.38 [99% CI, 0.02-0.74]; speed-of-processing: effect size, 0.36 [99% CI, 0.01-0.72]). At mean age of 82 years, about 60% of trained participants compared to 50% of controls (p<.05) were at or above their baseline level of self-reported IADL function at 10 years. The reasoning and speed-of-processing interventions maintained their effects on their targeted cognitive abilities at 10 years (reasoning: effect size, 0.23 [99% CI, 0.09-0.38]; speed-of-processing: effect size, 0.66 [99% CI, 0.43-0.88]). Memory training effects were no longer maintained for memory performance. Booster training produced additional and durable improvement for the reasoning intervention for reasoning performance (effect size, 0.21 [99% CI, 0.01-0.41]) and the speed-of-processing intervention for speed-of-processing performance (effect size, 0.62 [99% CI, 0.31-0.93]). Conclusions Each ACTIVE cognitive intervention resulted in less decline in self-reported IADL compared with the control group. Reasoning and speed, but not memory, training resulted in improved targeted cognitive abilities for 10 years. PMID:24417410

  20. The Effect of Donor Diabetes History on Graft Failure and Endothelial Cell Density Ten Years after Penetrating Keratoplasty

    PubMed Central

    Lass, Jonathan H.; Riddlesworth, Tonya D.; Gal, Robin L.; Kollman, Craig; Benetz, Beth A.; Price, Francis W.; Sugar, Alan; Terry, Mark A.; Soper, Mark; Beck, Roy W.

    2014-01-01

    Objective To examine the long term effect of donor diabetes history on graft failure and endothelial cell density (ECD) after penetrating keratoplasty (PKP) in the Cornea Donor Study Design Multi-center prospective, double-masked, controlled clinical trial Participants 1090 subjects undergoing PKP for a moderate risk condition, principally Fuchs’ dystrophy or pseudophakic/aphakic corneal edema (PACE), were enrolled by 105 surgeons from 80 clinical sites in the United States. Methods Corneas from donors 12 to 75 years old were assigned by 43 eye banks to participants without respect to recipient factors. Donor and recipient diabetes status was determined from existing medical records. Images of the central endothelium were obtained preoperatively (baseline) and at intervals for ten years postoperatively and analyzed by a central image analysis reading center to determine ECD. Main Outcome Measure(s) Time to graft failure (regraft or cloudy cornea for 3 consecutive months) and ECD. Results There was no statistically significant association of donor diabetes history with 10-year graft failure, baseline ECD, 10-year ECD or ECD values longitudinally over time in unadjusted analyses nor after adjusting for donor age and other significant covariates. The 10-year graft failure rate was 23% in the 199 cases receiving a cornea from a donor with diabetes versus 26% in the 891 cases receiving a cornea from a donor without diabetes (95% confidence interval for the difference: −10% to +6%; unadjusted p = 0.60). Baseline ECD (p=0.71), 10-year ECD (p>0.99), and changes in ECD over 10 years (p=0.86) were similar comparing donor diabetes and no-diabetes groups. Conclusions and Relevance The study results do not suggest an association between donor diabetes and PKP outcome. However, the assessment of donor diabetes was imprecise and based on historical data only. The increasing frequency of diabetes in the aging population in the United States affects the donor pool, thus the

  1. Ten years of health workforce planning in the Netherlands: a tentative evaluation of GP planning as an example

    PubMed Central

    2012-01-01

    Introduction In many countries, health-care labour markets are constantly being challenged by an alternation of shortage and oversupply. Avoiding these cyclic variations is a major challenge. In the Netherlands, a workforce planning model has been used in health care for ten years. Case description Since 1970, the Dutch government has explored different approaches to determine the inflow in medical schools. In 2000, a simulation model for health workforce planning was developed to estimate the required and available capacity of health professionals in the Netherlands. In this paper, this model is explained, using the Dutch general practitioners as an example. After the different steps in the model are clarified, it is shown how elements can be added to arrive at different versions of the model, or ‘scenarios’. A comparison is made of the results of different scenarios for different years. In addition, the subsequent stakeholder decision-making process is considered. Discussion and evaluation Discussion of this paper shows that workforce planning in the Netherlands is a complex modelling task, which is sensitive to different developments influencing the balance between supply and demand. It seems plausible that workforce planning has resulted in a balance between supply and demand of general practitioners. Still, it remains important that the modelling process is accepted by the different stakeholders. Besides calculating the balance between supply and demand, there needs to be an agreement between the stakeholders to implement the advised training inflow. The Dutch simulation model was evaluated using six criteria to be met by models suitable for policy objectives. This model meets these criteria, as it is a comprehensive and parsimonious model that can include all relevant factors. Conclusion Over the last decade, health workforce planning in the Netherlands has become an accepted instrument for calculating the required supply of health professionals on a

  2. Ten years of progress in the Hokkaido birth cohort study on environment and children's health: cohort profile--updated 2013.

    PubMed

    Kishi, Reiko; Kobayashi, Sachiko; Ikeno, Tamiko; Araki, Atsuko; Miyashita, Chihiro; Itoh, Sachiko; Sasaki, Seiko; Okada, Emiko; Kobayashi, Sumitaka; Kashino, Ikuko; Itoh, Kumiko; Nakajima, Sonomi

    2013-11-01

    The Hokkaido Study on Environment and Children's Health is an ongoing cohort study that began in 2002. The study consists of two prospective birth cohorts, the Sapporo cohort (n = 514) and the Hokkaido large-scale cohort (n = 20,940). The primary goals of this study are to first examine the potential negative effects of perinatal environmental chemical exposures on birth outcomes, including congenital malformations and growth retardation; second, to evaluate the development of allergies, infectious diseases and neurodevelopmental disorders and perform longitudinal observations of the children's physical development to clarify the causal relationship between these outcomes and environmental chemicals; third, to identify individuals genetically susceptible to environmental chemicals; finally, to identify the additive effects of various environmental factors in our daily life, such as secondhand smoke exposure or low folate intake during early pregnancy. In this paper, we introduce our recent progress in the Hokkaido study with a cohort profile updated in 2013. For the last ten years, we followed pregnant women and their offspring, measuring various environmental chemicals, i.e., PCB, OH-PCB and dioxins, PFCs (Perfluorinated Compounds), Organochlorine pesticides, Phthalates, bisphenol A and mercury. We discovered that the concentration of toxic equivalents (TEQ) of dioxin and other specific congeners of PCDF or PCDD have effects on birth weight, infants' neurodevelopment and immune function. There were significant gender differences in these effects; our results suggest that male infants have more susceptibility to those chemical exposures than female infants. Interestingly, we found maternal genetic polymorphisms in AHR, CYP1A1 or GSTs that significantly modified the dioxin concentrations in maternal blood, suggesting different dioxin accumulations in the bodies of individuals with these genotypes, which would lead to different dioxin exposure levels. These genetic

  3. Heterosexual transmission of human immunodeficiency virus (HIV) in northern California: results from a ten-year study.

    PubMed

    Padian, N S; Shiboski, S C; Glass, S O; Vittinghoff, E

    1997-08-15

    To examine rates of and risk factors for heterosexual transmission of human immunodeficiency virus (HIV), the authors conducted a prospective study of infected individuals and their heterosexual partners who have been recruited since 1985. Participants were recruited from health care providers, research studies, and health departments throughout Northern California, and they were interviewed and examined at various study clinic sites. A total of 82 infected women and their male partners and 360 infected men and their female partners were enrolled. Over 90% of the couples were monogamous for the year prior to entry into the study; < 3% had a current sexually transmitted disease (STD). The median age of participants was 34 years, and the majority were white. Over 3,000 couple-months of data were available for the follow-up study. Overall, 68 (19%) of the 360 female partners of HIV-infected men (95% confidence interval (CI) 15.0-23.3%) and two (2.4%) of the 82 male partners of HIV-infected women (95% CI 0.3-8.5%) were infected. History of sexually transmitted diseases was most strongly associated with transmission. Male-to-female transmission was approximately eight-times more efficient than female-to-male transmission and male-to-female per contact infectivity was estimated to be 0.0009 (95% CI 0.0005-0.001). Over time, the authors observed increased condom use (p < 0.001) and no new infections. Infectivity for HIV through heterosexual transmission is low, and STDs may be the most important cofactor for transmission. Significant behavior change over time in serodiscordant couples was observed. PMID:9270414

  4. Duration of Sexual Harassment and Generalized Harassment in the Workplace Over Ten Years: Effects on Deleterious Drinking Outcomes

    PubMed Central

    McGinley, Meredith; Richman, Judith A.; Rospenda, Kathleen M.

    2012-01-01

    While harassment in the workplace has been linked to deleterious drinking outcomes, researchers have yet to examine the long-term effects of chronic workplace harassment. During a ten year longitudinal mail survey, university employees (N = 2265) were administered measures of sexual harassment, generalized workplace harassment, and problematic drinking. Using growth mixture modeling, two latent classes of workplace harassment emerged: infrequent and chronic. Demographic characteristics (gender, age, and race) predicted the shape of the trajectories and likelihood of class membership. As hypothesized, membership in the chronic harassment classes was linked to future problematic drinking, even after controlling for previous drinking. PMID:21745045

  5. Sexual behavior research on a cohort of gay men, 1984-1990: can we predict how men will respond to interventions?

    PubMed

    Ostrow, D G; Beltran, E; Joseph, J

    1994-10-01

    In 1984, over 1000 gay and bisexual men volunteered to participate in both the Chicago Multicenter AIDS Cohort Study (MACS) and a companion psychosocial study, the Coping and Change Study (CCS). Participants in the semiannual Chicago MACS/CCS evaluations comprise the largest cohort of high-risk men under continuous medical, behavioral, and psychosocial observation. Chicago MACS/CCS researchers prospectively chart the sexual behavior change patterns of the cohort and relate those behavioral changes to psychosocial correlates and actual HIV infection risk. This report summarizes the behavioral natural history of the Chicago MACS/CCS cohort from 1984 to 1990, focusing on receptive anal sex practices and use patterns for alcohol and the most frequently used recreational drugs. As these are prospective observational and not controlled intervention studies, psychosocial correlates of sexual behavior change by members of the cohort are suggestive of factors influencing behavior change rather than indicative of causal relationships. However, the voluntary availability to participants in the Chicago MACS/CCS of HIV-1 antibody test results beginning in late 1985 provided the opportunity to examine whether demographic, psychosocial, or behavioral factors were indicators of sexual behavior change following disclosure and counseling about HIV-1 serostatus. Recommendations for promotion and maintenance of safer sexual behavior for the long run, and limitations in the generalizability of these findings to the much more diverse populations of men who have sex with other men conclude this article. PMID:7998814

  6. What I've Learned about Charter Schools after Ten Years on the Front Lines

    ERIC Educational Resources Information Center

    Turnamian, Peter

    2011-01-01

    The charter school movement is prepared to expand at rates once unimaginable. Yet, a glaring hypocrisy exists in the movement that education and political leaders seem eager to ignore. The charter school movement stakes its very effectiveness and value on increased levels of accountability and measurable student achievement results; but it fails…

  7. Position Paper on Use of Stereoscopy to Support Science Learning: Ten Years of Research

    ERIC Educational Resources Information Center

    Price, C. Aaron; Lee, Hee-Sun; Plummer, Julia D.; SubbaRao, Mark; Wyatt, Ryan

    2015-01-01

    Stereoscopy's potential as a tool for science education has been largely eclipsed by its popularity as an entertainment platform and marketing gimmick. Dozens of empirical papers have been published in the last decade about the impact of stereoscopy on learning. As a result, a corpus of research now points to a coherent message about how, when,…

  8. Ten Years of Vegetation Change in Northern California Marshlands Detected using Landsat Satellite Image Analysis

    NASA Technical Reports Server (NTRS)

    Potter, Christopher

    2013-01-01

    The Landsat Ecosystem Disturbance Adaptive Processing System (LEDAPS) methodology was applied to detected changes in perennial vegetation cover at marshland sites in Northern California reported to have undergone restoration between 1999 and 2009. Results showed extensive contiguous areas of restored marshland plant cover at 10 of the 14 sites selected. Gains in either woody shrub cover and/or from recovery of herbaceous cover that remains productive and evergreen on a year-round basis could be mapped out from the image results. However, LEDAPS may not be highly sensitive changes in wetlands that have been restored mainly with seasonal herbaceous cover (e.g., vernal pools), due to the ephemeral nature of the plant greenness signal. Based on this evaluation, the LEDAPS methodology would be capable of fulfilling a pressing need for consistent, continual, low-cost monitoring of changes in marshland ecosystems of the Pacific Flyway.

  9. Near-infrared laser treatment of complicated hemangiomas in children: ten-year clinical experience

    NASA Astrophysics Data System (ADS)

    Abushkin, Ivan A.; Privalov, Valeriy A.; Lappa, Alexander V.

    2011-03-01

    Results of application of low invasive laser technology (developed by authors: Proc. SPIE 5863, 107-115 (2005), Russian Federation patent No.2290228 of.27.12.06) to treatment of hemangiomas in children are presented and analyzed in this work. From 2001 the technology was applied to about 1500 children with more than 2000 hemangiomas. Majority of them were complicated ones: belong to cavernous or combined types or (and) were localized on problem places: on face near eyes, nose, and lips, on auricles, on perineum near anus and genitals, in respiratory and gastrointestinal tracts. Diode laser with wavelength 920, 970, and 1060 nm at distant and interstitial irradiation were applied. In case of need there applied endoscopes. Excellent and good results have been achieved in 94% cases; there was a significant improvement in the rest cases.

  10. Ten Years of Linear Endobronchial Ultrasound: Evidence of Efficacy, Safety and Cost-effectiveness.

    PubMed

    Fernández-Villar, Alberto; Mouronte-Roibás, Cecilia; Botana-Rial, Maribel; Ruano-Raviña, Alberto

    2016-02-01

    Real-time endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is one of the major landmarks in the history of bronchoscopy. In the 10 years since it was introduced, a vast body of literature on the procedure and its results support the use of this technique in the study of various mediastinal and pulmonary lesions. This article is a comprehensive, systematic review of all the available scientific evidence on the more general indications for this technique. Results of specific studies on efficacy, safety and cost-effectiveness available to date are examined. The analysis shows that EBUS-TBNA is a safe, cost-effective technique with a high grade of evidence that is a valuable tool in the diagnosis and mediastinal staging of patients with suspected or confirmed lung cancer. However, more studies are needed to guide decision-making in the case of a negative result. Evidence on the role of EBUS-TBNA in the diagnosis of sarcoidosis and extrathoracic malignancies is also high, but much lower when used in the study of tuberculosis, lymphoma and for the re-staging of lung cancer after neoadjuvant chemotherapy. Nevertheless, due to its good safety record and lack of invasiveness compared to surgical techniques, the grade of evidence for recommending EBUS-TBNA as the initial diagnostic test in patients with these diseases is very high in most cases. PMID:26565072

  11. Ten years of preanalytical monitoring and control: Synthetic Balanced Score Card Indicator

    PubMed Central

    López-Garrigós, Maite; Flores, Emilio; Santo-Quiles, Ana; Gutierrez, Mercedes; Lugo, Javier; Lillo, Rosa; Leiva-Salinas, Carlos

    2015-01-01

    Introduction Preanalytical control and monitoring continue to be an important issue for clinical laboratory professionals. The aim of the study was to evaluate a monitoring system of preanalytical errors regarding not suitable samples for analysis, based on different indicators; to compare such indicators in different phlebotomy centres; and finally to evaluate a single synthetic preanalytical indicator that may be included in the balanced scorecard management system (BSC). Materials and methods We collected individual and global preanalytical errors in haematology, coagulation, chemistry, and urine samples analysis. We also analyzed a synthetic indicator that represents the sum of all types of preanalytical errors, expressed in a sigma level. We studied the evolution of those indicators over time and compared indicator results by way of the comparison of proportions and Chi-square. Results There was a decrease in the number of errors along the years (P < 0.001). This pattern was confirmed in primary care patients, inpatients and outpatients. In blood samples, fewer errors occurred in outpatients, followed by inpatients. Conclusion We present a practical and effective methodology to monitor unsuitable sample preanalytical errors. The synthetic indicator results summarize overall preanalytical sample errors, and can be used as part of BSC management system. PMID:25672466

  12. Granulomatous Mastitis: A Ten-Year Experience at a University Hospital

    PubMed Central

    Korkut, Ercan; Akcay, Mufide Nuran; Karadeniz, Erdem; Subasi, Irmak Durur; Gursan, Nesrin

    2015-01-01

    Objective: In this study we aimed to define clinical, radiologic and pathological specialties of patients who applied to General Surgery Department of Atatürk University Medical Faculty with granulomatous mastitis and show medical and surgical treatment results. With the help of this study we will be able to make our own clinical algorithm for diagnosis and treatment. Materials and Methods: We searched retrospectively addresses, phone numbers and clinical files of 93 patients whom diagnosed granulomatous mastitis between a decade of January 2001 – December 2010. We noted demographic specialties, ages, gender, medical family history, main complaints, physical findings, radiological and laboratory findings, medical treatments, postoperative complications and surgical procedures if they were operated; morbidity, recurrence and success ratios, complications after treatment for patients discussed above. Results: In this study we evaluated 93 patients, 91 females and 2 males, with granulomatous mastitis retrospectively who applied to General Surgery Department of Atatürk University Medical Faculty between January 2001 and December 2010. Mean age was 34.4 years. The diagnosis was confirmed by histopathologic examination of the lesions. Seventy three patients had idiopathic granulomatous lobular mastitis and 20 patients had specific granulomatous mastitis IGM (18 tuberculosis mastitis, 1 alveolar echinococcosis and 1 silk reaction). All the patients had surgical debridement or antibiotic, and anti-inflammatory treatment with results bad clinical response before applied our clinic. Conclusion: Empiric antibiotic therapy and drainage of the breast lesions are not enough for complete remission of idiopathic granulomatous mastitis. The lesion must be excised completely. In selected patients, corticosteroid therapy can be useful. In the patients with tuberculous mastitis, abscess drainage and antituberculous therapy can be useful, but wide excision must be chosen for the

  13. Ten-Year Incidence of Chagas Cardiomyopathy Among Asymptomatic Trypanosoma cruzi–Seropositive Former Blood Donors

    PubMed Central

    Sabino, Ester C.; Ribeiro, Antonio L.; Salemi, Vera M.C.; Di Lorenzo Oliveira, Claudio; Antunes, Andre P.; Menezes, Marcia M.; Ianni, Barbara M.; Nastari, Luciano; Fernandes, Fabio; Patavino, Giuseppina M.; Sachdev, Vandana; Capuani, Ligia; de Almeida-Neto, Cesar; Carrick, Danielle M.; Wright, David; Kavounis, Katherine; Goncalez, Thelma T.; Carneiro-Proietti, Anna Barbara; Custer, Brian; Busch, Michael P.; Murphy, Edward L.

    2013-01-01

    Background Very few studies have measured disease penetrance and prognostic factors of Chagas cardiomyopathy among asymptomatic Trypanosoma cruzi–infected persons. Methods and Results We performed a retrospective cohort study among initially healthy blood donors with an index T cruzi–seropositive donation and age-, sex-, and period-matched seronegatives in 1996 to 2002 in the Brazilian cities of São Paulo and Montes Claros. In 2008 to 2010, all subjects underwent medical history, physical examination, ECGs, and echocardiograms. ECG and echocardiogram results were classified by blinded core laboratories, and records with abnormal results were reviewed by a blinded panel of 3 cardiologists who adjudicated the outcome of Chagas cardiomyopathy. Associations with Chagas cardiomyopathy were tested with multivariate logistic regression. Mean follow-up time between index donation and outcome assessment was 10.5 years for the seropositives and 11.1 years for the seronegatives. Among 499 T cruzi seropositives, 120 (24%) had definite Chagas cardiomyopathy, and among 488 T cruzi seronegatives, 24 (5%) had cardiomyopathy, for an incidence difference of 1.85 per 100 person-years attributable to T cruzi infection. Of the 120 seropositives classified as having Chagas cardiomyopathy, only 31 (26%) presented with ejection fraction <50%, and only 11 (9%) were classified as New York Heart Association class II or higher. Chagas cardiomyopathy was associated (P<0.01) with male sex, a history of abnormal ECG, and the presence of an S3 heart sound. Conclusions There is a substantial annual incidence of Chagas cardiomyopathy among initially asymptomatic T cruzi–seropositive blood donors, although disease was mild at diagnosis. PMID:23393012

  14. Parental perceptions of children's modesty: a cross-sectional survey of ages two to ten years.

    PubMed

    Rosenfeld, A; Siegel-Gorelick, B; Haavik, D; Duryea, M; Wenegrat, A; Martin, J; Bailey, R

    1984-11-01

    Modesty has been defined as decorum in relation to physical nakedness, and sexual and eliminative behavior (Newson and Newson 1968). The connection between nakedness, sexuality, and modesty with respect to family members dates back millennia. Leviticus prohibited incest with the phrase, "Thou shalt not uncover the nakedness of ..." and then specified a lengthy list of forbidden relatives. We will review contemporary theories and research projects concerning modesty and then discuss the results of a study we designed in order to investigate age trends in the development of modesty. PMID:6334863

  15. The Fund for Astrophysical Research: Ten Years of the Small Grants Program

    NASA Astrophysics Data System (ADS)

    Upgren, A. R.; Aller, L. H.; Dunham, W. B.; Philip, A. G. Davis

    1996-12-01

    The Fund for Astrophysical Research, Inc. is a non-profit research corporation, incorporated under the laws of New York State in 1936. It was founded in that year by Charles G. Thompson and Alice Bemis Thompson, to advance research in astrophysics. Theodore Dunham, Jr. served as its scientific director from its founding until his death in 1984. In 1985, the FAR created a program to distribute small research grants among the North American community of astronomers. The grants were named in honor of Dunham. This paper summarizes the results of the first decade of the program.

  16. Ten-Year Retrospective Longitudinal-Study of Student Perspectives on Value of REU

    NASA Astrophysics Data System (ADS)

    Slater, T. F.; Slater, S. J.

    2013-12-01

    For more than two decades, federal agencies have been enthusiastically supporting summer research experiences for undergraduates. These REU programs are tacitly intended to increase retention and provide "an important educational experience" for undergraduates, particularly women, minorities and underrepresented groups. Numerous authors (viz., Laursen, Lopatto, Dolan, among many others) have enthusiastically described positive impacts of summer REU programs from exit interview data. These results include enhanced persistence to pursue STEM careers and confirmed desire to attend graduate school in the field targeted by a particular REU. Perhaps surprisingly, negative student experiences are rarely described in the scholarly literature, but do appear in more informal publications (viz., Gueterma, 2007). One wonders how REU alumni, looking back over their entire collective portfolio of experiences, now perceive the educational value of their REU experience relative to their other educational experiences. To obtain a backwards-looking, reflective description from REU alumni on the value of their REU experiences, we conducted a 10-year, two-stage study was designed to explore the ways in which the REU acted as an educational experience for 51 women from a single geoscience sub-discipline. The first phase was an ex post facto longitudinal analysis of data, including multiple interviews with each participant during their REU, annual open-ended alumni surveys, faculty interviews, and extensive field notes, over a 10-year period. This analysis informed the second phase, a clinical interview. Over 10 hours of interviews with 8 participants were conducted and analyzed. These 8 participants were selected to represent a variety of career stages, and for their potential to reflect on a wide variety of educational experiences. Results from the interviews, done many years after their REU experience, indicate that the interviewees' REU did not provide a substantive educational

  17. Relaxation training for anxiety: a ten-years systematic review with meta-analysis

    PubMed Central

    Manzoni, Gian Mauro; Pagnini, Francesco; Castelnuovo, Gianluca; Molinari, Enrico

    2008-01-01

    Background Relaxation training is a common treatment for anxiety problems. Lacking is a recent quantitative meta-analysis that enhances understanding of the variability and clinical significance of anxiety reduction outcomes after relaxation treatment. Methods All studies (1997–2007), both RCT, observational and without control group, evaluating the efficacy of relaxation training (Jacobson's progressive relaxation, autogenic training, applied relaxation and meditation) for anxiety problems and disorders were identified by comprehensive electronic searches with Pubmed, Psychinfo and Cochrane Registers, by checking references of relevant studies and of other reviews. Our primary outcome was anxiety measured with psychometric questionnaires. Meta-analysis was undertaken synthesizing the data from all trials, distinguishing within and between effect sizes. Results 27 studies qualified for the inclusion in the meta-analysis. As hypothesized, relaxation training showed a medium-large effect size in the treatment of anxiety. Cohen's d was .57 (95% CI: .52 to .68) in the within analysis and .51 (95% CI: .46 to .634) in the between group analysis. Efficacy was higher for meditation, among volunteers and for longer treatments. Implications and limitations are discussed. Conclusion The results show consistent and significant efficacy of relaxation training in reducing anxiety. This meta-analysis extends the existing literature through facilitation of a better understanding of the variability and clinical significance of anxiety improvement subsequent to relaxation training. PMID:18518981

  18. Ten Years of Forest Cover Change in the Sierra Nevada Detected Using Landsat Satellite Image Analysis

    NASA Technical Reports Server (NTRS)

    Potter, Christopher S.

    2014-01-01

    The Landsat Ecosystem Disturbance Adaptive Processing System (LEDAPS) methodology was applied to detected changes in forest vegetation cover for areas burned by wildfires in the Sierra Nevada Mountains of California between the periods of 1975- 79 and 1995-1999. Results for areas burned by wildfire between 1995 and 1999 confirmed the importance of regrowing forest vegetation over 17% of the combined burned areas. A notable fraction (12%) of the entire 5-km (unburned) buffer area outside the 1995-199 fires perimeters showed decline in forest cover, and not nearly as many regrowing forest areas, covering only 3% of all the 1995-1999 buffer areas combined. Areas burned by wildfire between 1975 and 1979 confirmed the importance of disturbed (or declining evergreen) vegetation covering 13% of the combined 1975- 1979 burned areas. Based on comparison of these results to ground-based survey data, the LEDAPS methodology should be capable of fulfilling much of the need for consistent, low-cost monitoring of changes due to climate and biological factors in western forest regrowth following stand-replacing disturbances.

  19. Ten Years of Patient Surveys in Accredited Breast Centers in North Rhine-Westphalia

    PubMed Central

    Ansmann, L.; Kowalski, C.; Pfaff, H.

    2016-01-01

    Introduction: Patient surveys are an established tool for quality control in healthcare organizations. This report looks at the design and development of the annual patient surveys carried out among breast cancer patients treated in the Breast Centers of North Rhine-Westphalia and discusses selected findings from 10 consecutive years. Material and Methods: Since 2006 the Institute for Medical Sociology, Health Services Research and Rehabilitation Science (IMVR) of the University of Cologne has carried out an annual survey of breast cancer patients using the Cologne Patient Questionnaire for Breast Cancer. The patients included in the survey have been diagnosed with primary breast cancer and undergo surgery between February and July in one of the Breast Centers in North Rhine-Westphalia accredited by the medical association of Westphalia-Lippe. The questionnaire and the type of feedback given to the Breast Centers were comprehensively revised in 2014. Selected results collected over the survey period were analyzed descriptively. Results: The survey period of 10 years provides information on the actual medical care delivered in the Breast Centers based on the data obtained in this period from around 40 000 patients. Some areas showed positive developments over time. Conclusion: The approach used to survey patients, the Cologne Patient Questionnaire for Breast Cancer 2.0 and the benchmark-focused feedback provide an impetus for organizational learning in Breast Centers. The concept could also be used in other healthcare organizations to stimulate learning and improve healthcare services. PMID:26855439

  20. Ten-year climatological features and air origin of midlatitude double tropopauses

    NASA Astrophysics Data System (ADS)

    Wu, Xue; Lü, Daren

    2015-12-01

    The 10-year climatological features related to midlatitude double tropopause events (DTs) are examined using ERAInterim data from 2003 to 2012. The analysis is based on tropopauses defined by lapse rate. Results show that DTs are permanent or semi-permanent in the midlatitudes, and high DT frequency bands move poleward in winter and equatorward in summer, which is consistent with the seasonal movement of the subtropical jet. Based on our statistics, the second tropopause is found at about 100 hPa in the subtropics and at slightly lower altitudes in sub-polar regions. The thickness between the first and second tropopause is smaller in the subtropics and increases with latitude. Next, the origin of air sandwiched between the first and second tropopause of DTs is studied with a revised version of the UK Universities Global Atmospheric Modelling Programme Offline Trajectory Code (Version 3) diabatic trajectory model. The results show that, in the lower or middle troposphere, air is transported into the DTs from lower latitudes, mainly in the tropics. The dominant source regions are mainly areas of deep convection and steep orography, e.g., the western Pacific and Himalayan Mountains, and they show strong seasonality following the seasonal shift of these strong upwelling regions.

  1. Precipitation Climatology over Mediterranean Basin from Ten Years of TRMM Measurements

    NASA Technical Reports Server (NTRS)

    Mehta, Amita V.; Yang, Song

    2008-01-01

    Climatological features of mesoscale rain activities over the Mediterranean region between 5 W-40 E and 28 N-48 N are examined using the Tropical Rainfall Measuring Mission (TRMM) 3B42 and 2A25 rain products. The 3B42 rainrates at 3-hourly, 0.25 deg x 0.25 deg spatial resolution for the last 10 years (January 1998 to July 2007) are used to form and analyze the 5-day mean and monthly mean climatology of rainfall. Results show considerable regional and seasonal differences of rainfall over the Mediterranean Region. The maximum rainfall (3-5 mm/day) occurs over the mountain regions of Europe, while the minimum rainfall is observed over North Africa (approximately 0.5 mm/day). The main rainy season over the Mediterranean Sea extends from October to March, with maximum rainfall occurring during November-December. Over the Mediterranean Sea, an average rainrate of approximately 1-2 mm/day is observed, but during the rainy season there is 20% larger rainfall over the western Mediterranean Sea than that over the eastern Mediterranean Sea. During the rainy season, mesoscale rain systems generally propagate from west to east and from north to south over the Mediterranean region, likely to be associated with Mediterranean cyclonic disturbances resulting from interactions among large-scale circulation, orography, and land-sea temperature contrast.

  2. Ten-Year Follow-Up of Endovascular Aneurysm Treatment with Talent Stent-Grafts

    SciTech Connect

    Pitton, Michael B. Scheschkowski, Tobias; Ring, Markus; Herber, Sascha; Oberholzer, Katja; Leicher-Dueber, Annegret; Neufang, Achim; Schmiedt, Walther; Dueber, Christoph

    2009-09-15

    The purpose of this study was to evaluate the clinical results, complications, and secondary interventions during long-term follow-up after endovascular aneurysm repair (EVAR) and to investigate the impact of endoleak sizes on aneurysm shrinkage. From 1997 to March 2007, 127 patients (12 female, 115 male; age, 73.0 {+-} 7.2 years) with abdominal aortic aneurysms were treated with Talent stent-grafts. Follow-up included clinical visits, contrast-enhanced MDCT, and radiographs at 3, 6, and 12 months and then annually. Results were analyzed with respect to clinical outcome, secondary interventions, endoleak rate and management, and change in aneurysm size. There was no need for primary conversion surgery. Thirty-day mortality was 1.6% (two myocardial infarctions). Procedure-related morbidity was 2.4% (paraplegia, partial infarction of one kidney, and inguinal bleeding requiring surgery). Mean follow-up was 47.7 {+-} 34.2 months (range, 0-123 months). Thirty-nine patients died during follow-up; three of the deaths were related to aneurysm (aneurysm rupture due to endoleak, n = 1; secondary surgical reintervention n = 2). During follow-up, a total of 29 secondary procedures were performed in 19 patients, including 14 percutaneous procedures (10 patients) and 15 surgical procedures (12 patients), including 4 cases with late conversion to open aortic repair (stent-graft infection, n = 1; migration, endoleak, or endotension, n = 3). Overall mean survival was 84.5 {+-} 4.7 months. Mean survival and freedom from any event was 66.7 {+-} 4.5 months. MRI depicted significantly more endoleaks compared to MDCT (23.5% vs. 14.3%; P < 0.01). Patients in whom all aneurysm side branches were occluded prior to stent-grafting showed a significantly reduced incidence of large endoleaks. Endoleaks >10% of the aneurysm area were associated with reduced aneurysm shrinkage compared to no endoleaks or <10% endoleaks ({Delta} at 3 years, -1.8% vs. -12.0%; P < 0.05). In conclusion, endovascular

  3. Photodynamic therapy on spontaneous tumors of dogs and cats: a ten-year study

    NASA Astrophysics Data System (ADS)

    Fonda, Diego

    1992-06-01

    Since 1981, more than fifty spontaneous tumors of dogs and cats were treated by photodynamic therapy with hematoporphyrins in the surgery department of the University of Milan. Therapeutic results proved to be successful and promising in certain forms of cancer and will be compared in the future with the effectiveness of other photosensitizer drugs like phatolocyanines derivatives. Applied hematoporphyrins phototherapy methods included: (1) injection of hematoporphyrins derivative (HpD) and irradiation with laser light at 631 nanometers, using a Rhodamine B dye laser; (2) injection of the active component of hematoporphyrin derivative (DHE) and irradiation with a Rhodamine B dye laser; and (3) injection of DHE and irradiation with laser light at 628 nanometers using a gold vapor laser. More frequently treated tumor sites were oral and nasal cavities. Other localizations were mucous membranes of the glans and stomach. Nineteen histological types were diagnosed in treated tumors.

  4. Consequences of the Chernobyl fallout on some Italian underbrush produces: A ten-year study

    SciTech Connect

    Malanca, A.; Pessina, V.; Dallara, G.

    1996-11-01

    In this paper we present the results of a decennial (1986-1995) investigation on radiocaesium concentrations in soil, honey, mushrooms and other underbrush produces collected in a representative upland region of the Italian Apennines. Concentrations of {sup 134}Cs and {sup 137}Cs in numerous samples were determined by gamma-ray spectrometry. The data obtained showed a relatively high {sup 137}Cs concentration, up to 8973 Bq m{sup -2}, in the superficial (0-2 cm) mineral soil. In most of the mushrooms, as well as in other underbrush produces, the detected activities were generally <20 Bq kg{sup -1}. However, a high radiocontamination was observed in two species, namely Rozites Caperatus (with 584 and 735 Bq kg{sup -1} of {sup 137}Cs), and Tricholoma Nudum (3450 Bq kg{sup -1} ). Caesium concentration in honey showed a sharp increase soon after the Chernobyl accident, followed by a slow progressive decrease. 11 refs., 3 tabs.

  5. Combinatorics and probability: six- to ten-year-olds reliably predict whether a relation will occur.

    PubMed

    Gonzalez, Michel; Girotto, Vittorio

    2011-09-01

    Young children are able to judge which of two possibilities is more likely to occur when these possibilities are characterized by a simple property, like color ("Is it more likely to draw a red chip or a blue chip?"). Here we ask whether they can do so when the possibilities concern a relation between simple properties ("Is it more likely to draw two chips of the same color or two different colored chips?"). Three studies show that from the age of six children are able to predict the occurrence of a relation on the basis of its probability, and that from the age of nine their performance reaches adult levels. These results corroborate the theory of naive extensional reasoning, and are inconsistent with the hypothesis that children need the help of instruction to reason correctly about relations. PMID:21055735

  6. Ten-year measurements of gaseous pollutants in urban air by an open-path analyzer

    NASA Astrophysics Data System (ADS)

    Avino, P.; Manigrasso, M.

    2008-06-01

    Object of this study is the versatility of a remote-sensing measurement system through experimental survey of the levels of primary and secondary pollutants in urban areas. For the first time a long-range measurement of different pollutant for a long period are reported in the urban area of Rome. Over 10 years of data collection, levels of NO2, O3, SO2, benzene and toluene are measured and discussed by means of a differential optical absorption spectroscopy (DOAS) system installed at ground level. The period is interesting because it represents one of the most important life-changes in Europe and in Italy: in fact, during the 1990s some significant decrees introduced the catalytic pots and limited the amount of benzene and sulfur dioxide in the fuel. The paper will describe how the main primary and secondary pollutants are changed during all the period: particularly, benzene and SO2 are not over a big social problem for the human health whereas the secondary pollutants, ozone and nitrogen dioxide, have the same trends during the period, meaning a no contribution to their evolution from the atmospheric processes. The DOAS technique is resulted very useful and versatile: comparisons with other traditional analyzers (i.e., GC-PID for benzene and toluene investigations) demonstrate how it allows to have information over all the territory saving the qualitative trends and giving a similar quantitative result. In this respect the authors show that the difference is due to the different sampling ways (the traditional analyzers are punctual whereas the DOAS is a remote-sensing technique covering a wide area) and does not influence the atmospheric process interpretation. Finally, it should be considered that the pollutant trends have been interpreted using the concentration measurements of natural radioactivity as tracer of the dynamic properties of the atmospheric boundary layer.

  7. Ten Years Clinical Experience with Partial Ileal Bypass in Management of the Hyperlipidemias

    PubMed Central

    Buchwald, Henry; Moore, Richard B.; Varco, Richard L.

    1974-01-01

    The first partial ileal bypass operation specifically for the reduction of plasma lipids was performed by us in 1963. Since then we have operated upon and followed for more than three months 126 hyperlipidemic patients. Clinical metabolic studies, before and after the procedure, have demonstrated a 60% decrease in cholesterol absorption, a 3.8-fold increase in total fecal steroid excretion, a 5.7-fold increase in cholesterol synthesis, a 3-fold increase in cholesterol turnover, and a one-third decrease in the miscible cholesterol pool. Circulating cholesterol levels have been lowered an average 41.1% from the preoperative but postdietary baseline. An average 53% cholesterol reduction has been achieved from a pretreatment baseline using a combination of dietary and surgical management. Plasma triglycerides have been reduced in primary hypertriglyceridemic patients (type IV) an average of 52.6% from their preoperative but postdietary baseline. One patient died in the hospital and there have been 13 late deaths over the past 10 years. Four cases of postoperative bowel obstruction required reoperation. Diarrhea following partial ileal bypass is, as a rule, transistory and not a significant problem. No appreciable weight loss results from partial ileal bypass, which is an obvious distinction from the results of the far more massive jejuno-ileal bypass procedure for obesity. We have not encountered hepatotoxic, lithogenic, or nephrolithiasis complications in our partial ileal bypass patients. Sixty-nine per cent of our patients with preoperative angina pectoris have postoperative improvement or total remission of this symptom complex. Serial appraisal of followup coronary arteriographic studies offers preliminary evidence for lesion regression. It is concluded that partial ileal bypass is the most effective means for lipid reduction available today; it is obligatory in its actions, safe, and associated with minimal side effects. PMID:4416064

  8. Ten-year outcome of enzyme replacement therapy with agalsidase beta in patients with Fabry disease

    PubMed Central

    Germain, Dominique P; Charrow, Joel; Desnick, Robert J; Guffon, Nathalie; Kempf, Judy; Lachmann, Robin H; Lemay, Roberta; Linthorst, Gabor E; Packman, Seymour; Scott, C Ronald; Waldek, Stephen; Warnock, David G; Weinreb, Neal J; Wilcox, William R

    2015-01-01

    Background Fabry disease results from deficient α-galactosidase A activity and globotriaosylceramide accumulation causing renal insufficiency, strokes, hypertrophic cardiomyopathy and early demise. We assessed the 10-year outcome of recombinant α-galactosidase A therapy. Methods The outcomes (severe clinical events, renal function, cardiac structure) of 52/58 patients with classic Fabry disease from the phase 3 clinical trial and extension study, and the Fabry Registry were evaluated. Disease progression rates for patients with low renal involvement (LRI, n=32) or high renal involvement (HRI, n=20) at baseline were assessed. Results 81% of patients (42/52) did not experience any severe clinical event during the treatment interval and 94% (49/52) were alive at the end of the study period. Ten patients reported a total of 16 events. Patients classified as LRI started therapy 13 years younger than HRI (mean 25 years vs 38 years). Mean slopes for estimated glomerular filtration rate for LRI and HRI were −1.89 mL/min/1.73 m2/year and −6.82 mL/min/1.73 m2/year, respectively. Overall, the mean left ventricular posterior wall thickness and interventricular septum thickness remained unchanged and normal. Patients who initiated treatment at age ≥40 years exhibited significant increase in left ventricular posterior wall thickness and interventricular septum thickness. Mean plasma globotriaosylceramide normalised within 6 months. Conclusions This 10-year study documents the effectiveness of agalsidase beta (1 mg/kg/2 weeks) in patients with Fabry disease. Most patients remained alive and event-free. Patients who initiated treatment at a younger age and with less kidney involvement benefited the most from therapy. Patients who initiated treatment at older ages and/or had advanced renal disease experienced disease progression. PMID:25795794

  9. Building Lasting Impact: Ten Years of the Earth to Sky Interagency Partnership

    NASA Astrophysics Data System (ADS)

    Davis, A.; Lacome, B.; Merrick, B.; Morris, J.; Paglierani, R.; Spakoff, S.

    2014-12-01

    Beginning in Fall of 2004, NASA and the National Park Service (NPS) embarked on collaborative work aimed at bringing the wonders of NASA science and education content into the hands of outstanding and highly regarded science "communicators" - interpreters in NPS. What began as a showcase of NASA content delivered in an interpretive workshop has evolved and matured into a long-standing, and growing partnership focused on climate change communication. The partnership has been fruitful and successful, producing a variety of professional development events that have resulted in participants reaching millions of Park and Refuge visitors and thousands of interpreters and educators, with content derived from our courses. Earth to Sky (ETS) now includes the US Fish and Wildlife Service and NOAA, and is working towards establishment of a network of regional networks made up of alumni and their communities. The key to our success has been the careful building and nurturing of the partnership, and its resulting community of practice, beginning with excellent facilitated meetings of the parties involved, and continuing through implementation of best practices in partnership and collaborative work. Project design, development, and execution were accomplished in true partnership with leaders from our intended audience, NPS interpreters, and later USFWS environmental educators. Our partners were fully involved, from the inception of the first workshop design, through its implementation and assessment, to strategic planning for sustainability and all subsequent efforts. ETS can serve as a model of an effective partnership in climate communication efforts, drawing upon the strengths of partners with widely different areas of expertise to produce cohesive work with high impact. We will share the ETS model of partnership, and discuss how this model might be useful as the climate communication community moves towards a more coherent approach to improve climate literacy.

  10. Ten years of monitoring the occupational radiation exposure in Bosnia and Herzegovina.

    PubMed

    Basić, B; Beganović, A; Samek, D; Skopljak-Beganović, A; Gazdić-Santić, M

    2010-01-01

    Monitoring of occupationally exposed persons in Bosnia and Herzegovina started in 1960s and it was interrupted in 1992. Dosimetry service resumed in 1999 when the International Atomic Energy Agency provided Harshaw 4500 TLD-reader and the first set of TLDs for the Radiation Protection Centre (RPC) of the Institute of Public Health of the Federation of Bosnia and Herzegovina. In January 2009, the RPC covered 1279 professionals with personal dosimetry, which is more than 70 % of all radiation workers in the country. Most of the TLD users work in medical institutions. In period 1999-2003 RPC provided 984 workers with dosemeters. In the next 5 y period (2004-2008), the number of persons covered by dosimetry increased by an average of 51 %. The mean and collective effective dose in the period 1999-2003 were 1.55 mSv and 1.54 personSv, respectively. In the period 2004-2008, the mean doses changed by 1 % on average, but the collective effective dose increased by 53 % for all practices. Mean and collective effective dose were 1.57 mSv and 2.34 personSv, respectively. The highest personal doses are associated with industrial radiography, than exposures in nuclear medicine. Radiology plays a significant role in collective dose only, whereas other exposures are low. Results correspond to results found in the literature. New practices in industry and medicine emphasise the need for more personal dosemeters, as well as specialised dosemeters for extremities monitoring, etc. PMID:20150230

  11. Ten year retrospective evaluation of the seasonal distribution of agent viruses in childhood respiratory tract infections

    PubMed Central

    Gülen, Figen; Yıldız, Başak; Çiçek, Candan; Demir, Esen; Tanaç, Remziye

    2014-01-01

    Aim: Infections caused by respiratory viruses sometimes occur as epidemias or pandemias and are an important public health problem in the whole world. These viral agents may lead to severe respiratory diseases especially in young children and in the elderly. The aim of this study was to determine the seasonal distribution of agent viruses in childhood respiratory infections in our region. Material and Methods: In this study, nasopharyngeal swab sample was obtained from 1 326 patients who presented to Ege University, Medical Faculty Children’s Hospital between 2002 and 2012 and who were thought to have respiratory tract infection. Influenza virus type A and B, respiratory syncytial virus, adenovirus and parainfluenza virus type 1–3 were investigated using shell-vial cell culture method and direct fluorescent antibody test and/or multiplex PCR test. Parainfluenza virus type 4, human metapneumovirus, rhinovirus, coronavirus, human bocavirus were investigated using multiplex PCR test. The seasonal distributions of the viruses were determined according to the results obtained from Ege University Medical Faculty, Department of Medical Microbiology Clinical Virology Laboratory. Approval was obtained from the ethics committee (Ege University Clinical Researches Ethics Committee, 12.02.2013, number: 13–1/46). Results: The majority of the patients who presented were outpatients (n:888, 67%) and the remainder were hospitalized patients (33%, n:438). Respiratory viruses were found in 503 of the nasopharyngeal swab samples (38%). Parainfluenza and respiratory syncytial virus were found most frequently in December–february (58% and 59%, respectively, influenza viruses were found most frequently in November–december (72%) and adenoviruses were found most frequently in may–september (56%). Conclusion: Although only supportive therapies are administered generally in viral infections, viral investigations are important in terms of determining the measures to be taken by

  12. Ten-Year Changes in Fusional Vergence, Phoria, and Nearpoint of Convergence in Myopic Children

    PubMed Central

    Anderson, Heather; Stuebing, Karla K.; Fern, Karen D.; Manny, Ruth E.

    2013-01-01

    Purpose To identify longitudinal changes in fusional vergence ranges and their relationship to other clinical measures in young myopic subjects. Methods Measurements were collected annually for 10 years on 114 subjects from the University of Houston Correction of Myopia Evaluation Trial cohort. Subject age was 7 to 13 years at year 1 of follow-up. Measurements included refractive error, distance and near phoria, interpupillary distance (IPD), prism bar fusional vergence ranges, and nearpoint of convergence (NPC). Multilevel modeling was used to determine baseline and rate of change for fusional vergence ranges and the impact of phoria, IPD, and NPC on these measures. Results Year 1 mean distance base-out (BO) break was 20 prism diopters (pd) and decreased 5.6 pd over 10 years (p <0.001). Mean near BO break was 30 pd at year 1 and decreased 9.4 pd over 10 years (p < 0.001). Greater esophoria was significantly related to greater BO break (p < 0.02) and receded NPC was significantly related to lower magnitude BO break at near (p < 0.001). Distance IPD increased 3 mm over 10 years (p < 0.001) but was unrelated to the magnitude of the BO ranges (p > 0.2). Mean distance base-in (BI) break was 7 pd at year 1 and increased 0.5 pd in 10 years (p = 0.04). Mean near BI break was 13 pd at year 1 and did not significantly change. Mean distance phoria was 0.1 pd exophoria at year 1 and did not change, whereas near phoria was 2.4 pd esophoria at year 1 and became more exophoric (4 pd in 10 years, p < 0.001). Conclusions These results suggest that for myopic children convergence ranges decrease for both distance and near viewing during the school years as near phoria becomes more exophoric. These findings could have clinical implications given that compensating convergence ranges decrease as near phoria becomes more divergent. PMID:21623250

  13. Ten years of anti-smoking programs in Italy: a review.

    PubMed

    Arciti, C; Pistone, M; Persici, P; Barbieri, A; Santi, L

    1995-01-01

    A diverse anti-smoking program for the prevention of cancer and cardiovascular diseases has been ongoing in Italy since 1981, coordinated by the National Cancer Institute of Genoa and the Italian League Against Cancer of Genoa. The program includes several initiatives addressed to different target groups; schoolchildren and teachers, military personnel, doctors and nurses, and women. A preliminary inquiry on the attitudes and habits towards smoking was implemented by the distribution of questionnaires to the various groups involved in the program. An annual school-based anti-smoking program involves about 10,000 students aged four to 18 and their teachers. Meetings are delivered by experts to groups of 20 to 40 students with the aid of specific audiovisual material, which are periodically updated. Additional informative material, leaflets, and posters are distributed to both schoolchildren and teachers. Another educational program on primary prevention of smoking-related health hazards is addressed to military recruits, career soldiers, and medical officers. It consists of several initiatives: training of military doctors and nurses, lectures to military recruits, and distribution of informative material in the barracks. An annual meeting is organized to discuss program implementation and results. Surveys are carried out by distributing an anonymous questionnaire to health professionals in several Italian hospitals to assess the smoking habits of doctors and their attitudes and practices towards counseling patients against smoking. The results show marked differences in smoking habits in the cities under study. Annually since 1983, an updated course is organized and addressed to teachers of primary and secondary schools in Genoa. The aim of the course is to train school personnel and to help them to implement prevention programs in the schools, with the aid of experts in the field of prevention. A series of initiatives are addressed to women at different ages to

  14. [Ten-years records of organic arsenic (diphenylarsinic acid) poisoning: epidemiology, clinical feature, metabolism, and toxicity].

    PubMed

    Ishi, Kazuhiro; Tamaoka, Akira

    2015-01-01

    We report here the symptoms of diphenylarsinic acid (DPAA) poisoning recorded over 10 years since the DPAA contamination of the potable well water was first detected in the Kamisu City, Ibaraki Prefecture, in 2003. The poisoning symptoms associated with the cerebellum and brainstem included nystagmus, tremors, myoclonus, and cerebellar ataxia as well as the symptoms associated with the temporal and occipital lobes such as memory impairment, sleep disorder, and visual disturbance. Some of the affected children exhibited mental retardation. Moreover, reduced blood flow and reduced glucose metabolism in the cerebella, brainstem, and temporal and occipital lobes persisted for several years among the DPAA-exposed persons. Based on the animal studies for DPAA intoxication, the target organs for the DPAA toxicity were determined to be the central nervous system (CNS), liver, and biliary system. In particular, DPAA tends to persist in the brain for a long time, resulting in long-term impacts on the brain. The cerebral blood flow and brain glucose metabolism, which can be measured by positron emission tomography (PET) and single photon emission computed tomography (SPECT), respectively, are useful objective clinical markers to determine the effect of DPAA on CNS. We believe that continuous monitoring of the DPAA-exposed people may promote the effect of carcinogen and accelerate brain aging. PMID:25585431

  15. Ten year environmental test of glass fiber/epoxy pressure vessels

    NASA Technical Reports Server (NTRS)

    Faddoul, J. R.

    1985-01-01

    By the beginning of the 1970's composite pressure vessels had received a significant amount of development effort, and applications were beginning to be investigated. One of the first applications grew out of NASA Johnson Space Center efforts to develop a superior emergency breathing system for firemen. While the new breathing system provided improved wearer comfort and an improved mask and regulator, the primary feature was low weight which was achieved by using a glass fiber reinforced aluminum pressure vessel. Part of the development effort was to evaluate the long term performance of the pressure vessel and as a consequence, some 30 bottles for a test program were procured. These bottles were then provided to NASA Lewis Research Center where they were maintained in an outdoor environment in a pressurized condition for a period of up to 10 yr. During this period, bottles were periodically subjected to cyclic and burst testing. There was no protective coating applied to the fiberglass/epoxy composite, and significant loss in strength did occur as a result of the environment. Similar bottles stored indoors showed little, if any, degradation. This report contains a description of the pressure vessels, a discussion of the test program, data for each bottle, and appropriate plots, comparisons, and conclusions.

  16. Ten-Year Study of the Stringently Defined Otitis-prone Child in Rochester, NY.

    PubMed

    Pichichero, Michael E

    2016-09-01

    This review summarizes a prospective, longitudinal 10-year study in Rochester, NY, with virtually every clinically diagnosed acute otitis media (AOM) confirmed by bacterial culture of middle ear fluid. Children experiencing 3 episodes within 6 months or 4 episodes in 12 months were considered stringently defined otitis prone (sOP). We found stringent diagnosis compared with clinical diagnosis reduced the frequency of children meeting the OP definition from 27% to 6% resulting in 14.8% and 2.4% receiving tympanostomy tubes, respectively. Significantly more often respiratory syncytial virus infection led to AOM in sOP than non-otitis-prone children that correlated with diminished total respiratory syncytial virus-specific serum IgG. sOP children produced low levels of antibody to Streptococcus pneumoniae and Haemophilus influenzae candidate vaccine protein antigens and to routine pediatric vaccines. sOP children generated significantly fewer memory B cells, functional and memory T cells to otopathogens following nasopharyngeal colonization and AOM than non-otitis-prone children and they had defects in antigen-presenting cells. PMID:27273691

  17. A ten-year review of commercial vaccine performance for control of tick infestations on cattle.

    PubMed

    de la Fuente, José; Almazán, Consuelo; Canales, Mario; Pérez de la Lastra, José Manuel; Kocan, Katherine M; Willadsen, Peter

    2007-06-01

    Ticks are important ectoparasites of domestic and wild animals, and tick infestations economically impact cattle production worldwide. Control of cattle tick infestations has been primarily by application of acaricides which has resulted in selection of resistant ticks and environmental pollution. Herein we discuss data from tick vaccine application in Australia, Cuba, Mexico and other Latin American countries. Commercial tick vaccines for cattle based on the Boophilus microplus Bm86 gut antigen have proven to be a feasible tick control method that offers a cost-effective, environmentally friendly alternative to the use of acaricides. Commercial tick vaccines reduced tick infestations on cattle and the intensity of acaricide usage, as well as increasing animal production and reducing transmission of some tick-borne pathogens. Although commercialization of tick vaccines has been difficult owing to previous constraints of antigen discovery, the expense of testing vaccines in cattle, and company restructuring, the success of these vaccines over the past decade has clearly demonstrated their potential as an improved method of tick control for cattle. Development of improved vaccines in the future will be greatly enhanced by new and efficient molecular technologies for antigen discovery and the urgent need for a tick control method to reduce or replace the use of acaricides, especially in regions where extensive tick resistance has occurred. PMID:17692140

  18. Isotopic abundance in the CN coma of comets: Ten years of measurements

    NASA Astrophysics Data System (ADS)

    Schulz, R.; Jehin, E.; Manfroid, J.; Hutsemékers, D.; Arpigny, C.; Cochran, A.; Zucconi, J.-M.; Stüwe, J. A.

    2008-11-01

    Over the past 10 years the isotopic ratios of carbon ( 12C/ 13C) and nitrogen ( 14N/ 15N) have been determined for a dozen comets, bright enough to allow obtaining the required measurements from the ground. The ratios were derived from high-resolution spectra of the CN coma measured in the B 2∑ +-X 2∑ + (0, 0) emission band around 387 nm. The observed comets belong to different dynamical classes, including dynamically new as well as long- and short-period comets from the Halley- and Jupiter-family. In some cases the comets could be observed at various heliocentric distances. All values determined for the carbon and nitrogen isotopic ratios were consistent within the error margin irrespective of the type of comet or the heliocentric distance at which it was observed. Our investigations resulted in average ratios of 12C/ 13C=91±21 and nitrogen 14N/ 15N=141±29. Whilst the value for the carbon isotopic ratio is in good agreement with the solar and terrestrial value of 89, the nitrogen isotopic ratio is very different from the telluric value of 272.

  19. Cord Blood Banking and Transplantation in China: A Ten Years Experience of a Single Public Bank

    PubMed Central

    Liu, Jinhui; He, Ji; Chen, Shu; Qin, Fei; Wang, Fang; Xu, Gang; Zhu, Faming; Lv, Hangjun; Yan, Lixing

    2012-01-01

    Background Umbilical cord blood (UCB) has successfully used for transplantation to treat hematologic malignancies and genetic diseases. Herein, we describe the experience generated in a single public UCB bank at Zhejiang Province in China. Methods Good manufacturing practice and standard operating procedures were used to address donor selection as well as UCB collection, processing, and cryopreservation. Total nucleated cells (TNCs), cellular viability, CD34+ cells, and colony-forming units were determined, and infectious diseases screening test, sterility test, and HLA typing for UCB units were done. Results Only 18.51% of all collected UCB units met storage criteria, and 7,056 UCB units were cryopreserved in 10 years. The volume of UCB units was 95.0 ± 22.0 ml. The number of TNCs before and after processing was 13.32 ± 3.63 × 108 and 10.63 ± 2.80 × 108, respectively, and the recovery rate was 80.71 ± 11.26%. 0.4344 ± 0.1874% of the TNCs were CD34+ cells. The CFU-GM was 32.1 ± 28.0 colonies per 1 × 105 nucleated cells. Based mainly on HLA and nucleated cell content, 26 UCB units were released for transplantation. Conclusions A public UCB bank was successfully established in China; collection and processing of UCB units should be optimized in order to gain maximum volume and cell count. PMID:22896763

  20. Cord Blood Banking and Transplantation in China: A Ten Years Experience of a Single Public Bank.

    PubMed

    Liu, Jinhui; He, Ji; Chen, Shu; Qin, Fei; Wang, Fang; Xu, Gang; Zhu, Faming; Lv, Hangjun; Yan, Lixing

    2012-02-01

    BACKGROUND: Umbilical cord blood (UCB) has successfully used for transplantation to treat hematologic malignancies and genetic diseases. Herein, we describe the experience generated in a single public UCB bank at Zhejiang Province in China. METHODS: Good manufacturing practice and standard operating procedures were used to address donor selection as well as UCB collection, processing, and cryopreservation. Total nucleated cells (TNCs), cellular viability, CD34+ cells, and colony-forming units were determined, and infectious diseases screening test, sterility test, and HLA typing for UCB units were done. RESULTS: Only 18.51% of all collected UCB units met storage criteria, and 7,056 UCB units were cryopreserved in 10 years. The volume of UCB units was 95.0 ± 22.0 ml. The number of TNCs before and after processing was 13.32 ± 3.63 × 10(8) and 10.63 ± 2.80 × 10(8), respectively, and the recovery rate was 80.71 ± 11.26%. 0.4344 ± 0.1874% of the TNCs were CD34+ cells. The CFU-GM was 32.1 ± 28.0 colonies per 1 × 10(5) nucleated cells. Based mainly on HLA and nucleated cell content, 26 UCB units were released for transplantation. CONCLUSIONS: A public UCB bank was successfully established in China; collection and processing of UCB units should be optimized in order to gain maximum volume and cell count. PMID:22896763

  1. Advances in the Design and Synthesis of Prazosin Derivatives over the Last Ten Years

    PubMed Central

    Desiniotis, Andreas; Kyprianou, Natasha

    2012-01-01

    Introduction Mechanistic, translational and pharmacological studies led to the identification, preferred localization, binding characteristics, structure and functional properties of α1-adrenoceptor (α1-AR) subtypes in the bladder neck, bladder and prostate gland. The evidence gathered on α1-ARs, provided a molecular platform for the development of subtype selective antagonists, resulting in more effective approaches targeting those receptors for the treatment of outlet bladder obstruction and benign prostate hyperplasia. Areas Covered This review provides a comprehensive synopsis of advances over the last decade, in the design and optimization of Prazosin, Doxazosin, Terazosin quinazoline-based derivatives as clinically effective α1-AR antagonists. Furthermore, it discusses evidence on the metabolic and growth interference action by these agents, in addition to their smooth-muscle relaxing effects. The new action recognition emerges from compelling data on the inhibitory effect of quinazoline-based antagonists on primary tumor growth and progression to metastasis. In addition to the cellular findings in the prostate, functional validation and therapeutic impact of selected lead pharmaceutically optimized derivatives in the context of impairing vascularity and triggering tumor apoptosis, are also summarized. Expert Opinion The expanding knowledge on targeting intracellular signalling pathways driving the cellular response via an α1-AR dependent and independent antagonistic action, must be invested towards the optimization of new agents that while bypassing AR, exhibit improved pharmacological efficacy against human cancer. PMID:22148952

  2. Racial and nonracial discrimination and smoking status among South African adults ten years after apartheid

    PubMed Central

    Dutra, Lauren M; Williams, David R; Kawachi, Ichiro; Okechukwu, Cassandra A

    2014-01-01

    Background Despite a long history of discrimination and persisting racial disparities in smoking prevalence, little research exists on the relationship between discrimination and smoking in South Africa. Methods This analysis examined chronic (day to day) and acute (lifetime) experiences of racial and nonracial (e.g., age, gender, or physical appearance) discrimination and smoking status among respondents to the South Africa Stress and Health Study (SASH). Logistic regression models were constructed using SAS-Callable SUDAAN. Results Both chronic racial discrimination (RR=1.45, 95%CI: 1.14–1.85) and chronic nonracial discrimination (RR=1.69, 95%CI: 1.37–2.08) predicted a higher risk of smoking, but neither type of acute discrimination did. Total (sum of racial and nonracial) chronic discrimination (RR=1.46, 95%CI: 1.20–1.78) and total acute discrimination (RR=1.28, 95%CI: 1.01–1.60) predicted a higher risk of current smoking. Conclusions Racial and nonracial discrimination may be related to South African adults’ smoking behavior, but this relationship likely varies by the timing and frequency of these experiences. Future research should use longitudinal data to identify the temporal ordering of the relationships studied, include areas outside of South Africa to increase generalizability, and consider the implications of these findings for smoking cessation approaches in South Africa. PMID:24789604

  3. Multi-criteria decision analysis in environmental sciences: ten years of applications and trends.

    PubMed

    Huang, Ivy B; Keisler, Jeffrey; Linkov, Igor

    2011-09-01

    Decision-making in environmental projects requires consideration of trade-offs between socio-political, environmental, and economic impacts and is often complicated by various stakeholder views. Multi-criteria decision analysis (MCDA) emerged as a formal methodology to face available technical information and stakeholder values to support decisions in many fields and can be especially valuable in environmental decision making. This study reviews environmental applications of MCDA. Over 300 papers published between 2000 and 2009 reporting MCDA applications in the environmental field were identified through a series of queries in the Web of Science database. The papers were classified by their environmental application area, decision or intervention type. In addition, the papers were also classified by the MCDA methods used in the analysis (analytic hierarchy process, multi-attribute utility theory, and outranking). The results suggest that there is a significant growth in environmental applications of MCDA over the last decade across all environmental application areas. Multiple MCDA tools have been successfully used for environmental applications. Even though the use of the specific methods and tools varies in different application areas and geographic regions, our review of a few papers where several methods were used in parallel with the same problem indicates that recommended course of action does not vary significantly with the method applied. PMID:21764422

  4. Blunt traumatic rupture of the heart and pericardium: a ten-year experience (1979-1989).

    PubMed

    Fulda, G; Brathwaite, C E; Rodriguez, A; Turney, S Z; Dunham, C M; Cowley, R A

    1991-02-01

    Blunt traumatic rupture of the heart and pericardium, rarely diagnosed preoperatively, carries a high mortality rate. From 1979 to 1989, more than 20,000 patients were admitted to a Level I trauma center. A retrospective review identified 59 patients requiring emergency surgery for this condition. Injuries resulted from vehicular accidents (68%), motorcycle crashes (10%), pedestrians being struck by vehicles (7%), falls (5%), crushing (7%), and being struck by a horse (2%) or crane (2%). Seventeen patients (29%) had isolated rupture of the pericardium; 37 (63%) had ruptures of one or more cardiac chambers. All patients had signs of life at the scene or during transportation, but only 29 (49%) had vital signs on admission: 15 with chamber injury, 12 with pericardial rupture, and two with combined injuries. Diagnosis was established by emergency thoracotomy in the 30 patients who arrived in cardiac arrest. In the remaining 29 patients, diagnosis was made by urgent thoracotomy (41%), by subxiphoid pericardial window (34%), during laparotomy (21%), or by chest radiography (3%). The overall mortality rate was 76% (45 patients), but only 52% for those with vital signs on admission. Rapid transportation and expeditious surgical treatment can save many patients with these injuries. PMID:1994075

  5. A Ten-Year Molecular Survey on Parvoviruses Infecting Carnivores in Bulgaria.

    PubMed

    Filipov, C; Desario, C; Patouchas, O; Eftimov, P; Gruichev, G; Manov, V; Filipov, G; Buonavoglia, C; Decaro, N

    2016-08-01

    Parvoviruses represent the most important infectious agents that are responsible for severe to fatal disease in carnivores. This study reports the results of a 10-year molecular survey conducted on carnivores in Bulgaria (n = 344), including 262 dogs and 19 cats with gastroenteritis, and 57 hunted wild carnivores. Real-time polymerase chain reaction (qPCR), followed by virus characterization by minor groove binder (MGB) probe assays, detected 216 parvovirus positive dogs with a predominance of canine parvovirus type 2a (CPV-2a, 79.17%) over CPV-2b (18.52%) and CPV-2c (2.31%). Rottweilers and German shepherds were the most frequent breeds among CPV-positive pedigree dogs (n = 96). Eighteen cats were found to shed parvoviruses in their faeces, with most strains being characterized as FPLV (n = 17), although a single specimen tested positive for CPV-2a. Only two wild carnivores were parvovirus positive, a wolf (Canis lupus) and a red fox (Vulpes vulpes), both being infected by CPV-2a strains. PMID:25382194

  6. Ten Years of a National Oral Health Policy in Brazil: Innovation, Boldness, and Numerous Challenges.

    PubMed

    Pucca, G A; Gabriel, M; de Araujo, M E; de Almeida, F C S

    2015-10-01

    Brazil is the only country in the world to propose a universal health care system with the aim of guaranteeing delivery of all levels of health care, free of charge, to a population of over 200 million inhabitants by means of a unified health system ("Sistema Único de Saúde" [SUS]). The national policy of oral health, also known as Smiling Brazil ("Brasil Sorridente"), was implemented in 2004. Oral health was designated as 1 of the 4 priority areas of the SUS, transforming oral health care in Brazil, with the objective that the SUS achieve the integrality of care envisaged at its creation. The aim of this article is to share part of this experience in order to prompt reflection about the inclusion of oral health care in other health care systems around the world. The most significant results of Smiling Brazil can be seen in 3 areas: (1) oral health epidemiological indicators, (2) financial investment and professional development, and (3) the building of an oral health care network throughout the 10 y of the policy. The "Discovery!" article presented here portrays 10 y of evolution; however, it is important to point out that this is a process undergoing construction and that the oral health care network needs to be further expanded, refined, and solidified so that over time and through changes in the political parties in power, Smiling Brazil prevails as a perennial policy and not merely an action by a single government. PMID:26316461

  7. Congenital anomalies among live births in a polluted area. A ten-year retrospective study

    PubMed Central

    2012-01-01

    Background Congenital anomalies and their primary prevention are a crucial public health issue. This work aimed to estimate the prevalence of congenital anomalies in Brindisi, a city in southeastern Italy at high risk of environmental crisis. Methods This research concerned newborns up to 28 days of age, born between 2001 and 2010 to mothers resident in Brindisi and discharged with a diagnosis of congenital anomaly. We classified cases according to the coding system adopted by the European Network for the Surveillance of Congenital Anomalies (EUROCAT). Prevalence rates of congenital anomalies in Brindisi were compared with those reported by EUROCAT. Logistic regression models were adapted to evaluate the association between congenital anomalies and municipality of residence of the mother during pregnancy. Results Out of 8,503 newborns we recorded 194 subjects with congenital anomalies (228.2/10,000 total births), 1.2 times higher than the one reported by the EUROCAT pool of registries. We observed 83 subjects with congenital heart diseases with an excess of 49.1%. Odds Ratios for congenital heart diseases significantly increased for newborns to mothers resident in Brindisi (OR 1.75 CI 95% 1.30-2.35). Conclusions Our findings indicated an increased prevalence of Congenital Anomalies (especially congenital heart diseases) in the city of Brindisi. More research is needed in order to analyze the role of factors potentially involved in the causation of congenital anomalies. PMID:23270371

  8. Ten years trends (1984-1993) in the precipitation chemistry in central Austria

    NASA Astrophysics Data System (ADS)

    Puxbaum, H.; Simeonov, V.; Kalina, M. F.

    Since 1984, wet precipitation samples have been collected from five sampling sites in the eastern Alpine region of Austria. The chemical analysis performed included pH, NH 4+, Na +, K +, Ca 2+, Mg 2+, Cl -, NO 3- SO 42- and precipitation amount. These data were used to determine the 10 years (1984-1993) trends in precipitation chemistry and deposition for all major ions. The statistical data treatment by the use of least-squares linear regression revealed a significant decrease of sulfate and hydrogen ion concentrations and depositions at all sites in consideration (above 65% for hydrogen ion and over 33% for sulfate concentration and 40% for hydrogen and 36% for sulfate deposition). An effort is made to explain the acidity decrease not only by the parallel decrease of sulfate concentration but by the participation of the other constituents of the wet precipitation events. It has been found that when the hydrogen ion concentration decrease is stronger than that of sulfate ion concentrations a compensation mainly by ammonium ion concentration increase is achieved. On the contrary, when the hydrogen ion concentration decrease is weaker than sulfate concentration decrease, a calcium ion concentration decrease is present for the sites in consideration. The results obtained indicate that the precipitation chemistry in Central Austria follows the global trends of controlled reduction of atmospheric acidity.

  9. Ten Years of Land Cover Change on the California Coast Detected using Landsat Satellite Image Analysis

    NASA Technical Reports Server (NTRS)

    Potter, Christopher S.

    2013-01-01

    Landsat satellite imagery was analyzed to generate a detailed record of 10 years of vegetation disturbance and regrowth for Pacific coastal areas of Marin and San Francisco Counties. The Landsat Ecosystem Disturbance Adaptive Processing System (LEDAPS) methodology, a transformation of Tasseled-Cap data space, was applied to detected changes in perennial coastal shrubland, woodland, and forest cover from 1999 to 2009. Results showed several principal points of interest, within which extensive contiguous areas of similar LEDAPS vegetation change (either disturbed or restored) were detected. Regrowth areas were delineated as burned forest areas in the Point Reyes National Seashore (PRNS) from the 1995 Vision Fire. LEDAPS-detected disturbance patterns on Inverness Ridge, PRNS in areas observed with dieback of tanoak and bay laurel trees was consistent with defoliation by sudden oak death (Phytophthora ramorum). LEDAPS regrowth pixels were detected over much of the predominantly grassland/herbaceous cover of the Olema Valley ranchland near PRNS. Extensive restoration of perennial vegetation cover on Crissy Field, Baker Beach and Lobos Creek dunes in San Francisco was identified. Based on these examples, the LEDAPS methodology will be capable of fulfilling much of the need for continual, low-cost monitoring of emerging changes to coastal ecosystems.

  10. Ten Years of Cloud Properties from MODIS: Global Statistics and Use in Climate Model Evaluation

    NASA Technical Reports Server (NTRS)

    Platnick, Steven E.

    2011-01-01

    The NASA Moderate Resolution Imaging Spectroradiometer (MODIS), launched onboard the Terra and Aqua spacecrafts, began Earth observations on February 24, 2000 and June 24,2002, respectively. Among the algorithms developed and applied to this sensor, a suite of cloud products includes cloud masking/detection, cloud-top properties (temperature, pressure), and optical properties (optical thickness, effective particle radius, water path, and thermodynamic phase). All cloud algorithms underwent numerous changes and enhancements between for the latest Collection 5 production version; this process continues with the current Collection 6 development. We will show example MODIS Collection 5 cloud climatologies derived from global spatial . and temporal aggregations provided in the archived gridded Level-3 MODIS atmosphere team product (product names MOD08 and MYD08 for MODIS Terra and Aqua, respectively). Data sets in this Level-3 product include scalar statistics as well as 1- and 2-D histograms of many cloud properties, allowing for higher order information and correlation studies. In addition to these statistics, we will show trends and statistical significance in annual and seasonal means for a variety of the MODIS cloud properties, as well as the time required for detection given assumed trends. To assist in climate model evaluation, we have developed a MODIS cloud simulator with an accompanying netCDF file containing subsetted monthly Level-3 statistical data sets that correspond to the simulator output. Correlations of cloud properties with ENSO offer the potential to evaluate model cloud sensitivity; initial results will be discussed.

  11. Ten-year follow-up of the non-porous Allofit cementless acetabular component.

    PubMed

    Zenz, P; Stiehl, J B; Knechtel, H; Titzer-Hochmaier, G; Schwagerl, W

    2009-11-01

    Cementless acetabular fixation has demonstrated superior long-term durability in total hip replacement, but most series have studied implants with porous metal surfaces. We retrospectively evaluated the results of 100 consecutive patients undergoing total hip replacement where a non-porous Allofit component was used for primary press-fit fixation. This implant is titanium alloy, grit-blasted, with a macrostructure of forged teeth and has a biradial shape. A total of 81 patients (82 hips) were evaluated at final follow-up at a mean of 10.1 years (8.9 to 11.9). The Harris Hip Score improved from a mean 53 points (23 to 73) pre-operatively to a mean of 96 points (78 to 100) at final review. The osseointegration of all acetabular components was radiologically evaluated with no evidence of loosening. The survival rate with revision of the component as the endpoint was 97.5% (95% confidence interval 94 to 100) after 11.9 years. Radiolucency was found in one DeLee-Charnley zone in four acetabular components. None of the implants required revision for aseptic loosening. Two patients were treated for infection, one requiring a two-stage revision of the implant. One femoral stem was revised for osteolysis due to the production of metal wear debris, but the acetabular shell did not require revision. This study demonstrates that a non-porous titanium acetabular component with adjunct surface fixation offers an alternative to standard porous-coated implants. PMID:19880887

  12. Evaluating the Cause of Death in Obese Individuals: A Ten-Year Medical Autopsy Study

    PubMed Central

    Saab, Jad; Salvatore, Steven P.

    2015-01-01

    Background. Obesity is a growing public health problem associated with increased morbidity and rate of death. Postmortem examination is imperative to determine the cause of death, to detect clinically unsuspected disease entities, and consequently to determine the actual impact of obesity on patient mortality. Methods. A total of 849 adult autopsies were retrospectively reviewed. Obese (BMI ≥ 30 kg/m2) and nonobese patients were separately studied. The primary cause of death in each group was categorized into malignancy, infection, stroke, ischemic and nonischemic heart disease, pulmonary embolism, hemorrhage, and primary nonneoplastic diseases of different organ systems. Results. Of 849 autopsies, 32.3% were obese. The leading causes of death in the obese population were malignancy (31.4%), infection (25.9%), ischemic heart disease (12.8%), and pulmonary embolism (6.2%). Obese individuals were statistically more likely to die from pulmonary embolism and liver disease and less likely to die from neurologic diseases and nonischemic heart disease. Conclusion. Autopsies on obese individuals constitute a third of all adult medical autopsies in our center. Increased death rates in the obese due to pulmonary embolism and liver disease should receive special clinical attention. Autopsy findings in the obese population should contribute to overall premortem disease detection, prevention, and management. PMID:25653872

  13. Ten years of international collaboration in biomedical informatics and beyond: the AMAUTA program in Peru

    PubMed Central

    Fuller, Sherrilynne; Garcia, Patricia J; Holmes, King K; Kimball, Ann Marie

    2010-01-01

    Well-trained people are urgently needed to tackle global health challenges through information and communication technologies. In this report, AMAUTA, a joint international collaborative training program between the Universidad Peruana Cayetano Heredia and the University of Washington, which has been training Peruvian health professionals in biomedical and health informatics since 1999, is described. Four short-term courses have been organized in Lima, offering training to more than 200 graduate-level students. Long-term training to masters or doctorate level has been undertaken by eight students at the University of Washington. A combination of short-term and long-term strategies was found to be effective for enhancing institutional research and training enterprise. The AMAUTA program promoted the development and institution of informatics research and training capacity in Peru, and has resulted in a group of trained people playing important roles at universities, non-government offices, and the Ministry of Health in Peru. At present, the hub is being extended into Latin American countries, promoting South-to-South collaborations. PMID:20595317

  14. Combined First-Trimester Screening in Northern Finland: Experiences of the First Ten Years

    PubMed Central

    Merilainen, Anna; Peuhkurinen, Sini; Honkasalo, Timppa; Laitinen, Paivi; Kokkonen, Hannaleena; Ryynanen, Markku; Marttala, Jaana

    2014-01-01

    OBJECTIVE To evaluate the efficacy of first trimester combined screening for Down’s syndrome in Northern Finland during the first 10 years of practice. METHODS During 1 January 2002 to 31 December 2011, 47,896 women participated voluntarily in combined screening during first trimester. The risk cutoff was 1:250. The study period was divided into two time periods; 2002–2006 and 2007–2011. RESULTS During the first half of the study period, the detection rate (DR) was 77.3% with a 4.9% false-positive rate (FPR). During the latter half, the DR was 77.1% with a 2.8% FPR. CONCLUSIONS An important issue is the number of invasive procedures needed to detect one case of Down’s syndrome. The screening performance improved markedly in the latter five years period since the FPR lowered from 4.9% to 2.8% and the number of invasive procedures needed to detect one case of Down’s syndrome lowered from 15 to 11. PMID:25140118

  15. Ten-year-old children strategies in mental addition: A counting model account.

    PubMed

    Thevenot, Catherine; Barrouillet, Pierre; Castel, Caroline; Uittenhove, Kim

    2016-01-01

    For more than 30 years, it has been admitted that individuals from the age of 10 mainly retrieve the answer of simple additions from long-term memory, at least when the sum does not exceed 10. Nevertheless, recent studies challenge this assumption and suggest that expert adults use fast, compacted and unconscious procedures in order to solve very simple problems such as 3+2. If this is true, automated procedures should be rooted in earlier strategies and therefore observable in their non-compacted form in children. Thus, contrary to the dominant theoretical position, children's behaviors should not reflect retrieval. This is precisely what we observed in analyzing the responses times of a sample of 42 10-year-old children who solved additions with operands from 1 to 9. Our results converge towards the conclusion that 10-year-old children still use counting procedures in order to solve non-tie problems involving operands from 2 to 4. Moreover, these counting procedures are revealed whatever the expertise of children, who differ only in their speed of execution. Therefore and contrary to the dominant position in the literature according to which children's strategies evolve from counting to retrieval, the key change in development of mental addition solving appears to be a shift from slow to quick counting procedures. PMID:26402647

  16. The prospects of the Columbus programme ten years after its initiation

    NASA Astrophysics Data System (ADS)

    Vallerani, Ernesto

    1992-07-01

    A possible evolution of Columbus, bearing in mind the changes in the situation that have occurred over the last decade, is described. The ultimate goals that the program can realistically achieve in the international exploitation of space are focused upon. The large infrastructures which were conceived many years ago as an area of international cooperation in the conquest of space, and which started at the beginning of the 1980's with the Space Station and Columbus programs, have undergone a difficult development over the last decade and have had to suffer the resulting delays. The economic difficulties which faced the spacefaring nations, including Europe, in this period have led to much replanning and reprogramming which, together with the upheavals in the East, have demanded a rethinking of the strategies to achieve the original goals as fully as possible. The role of the Columbus Attached laboratory, or Attached Pressurized Module, as a European contribution to Space Station Freedom, in its new configuration dictated by the problems the U.S. has had to confront, is highlighted as an area for new strategies. Its basic features and characteristics are described. With regard to the Free Flying Laboratory, the prospects for this element will be the subject of new thinking, especially in the light of new international cooperation.

  17. Ten years of measured UV Index from the Spanish UVB Radiometric Network.

    PubMed

    Utrillas, M P; Marín, M J; Esteve, A R; Estellés, V; Gandía, S; Núnez, J A; Martínez-Lozano, J A

    2013-08-01

    An analysis is made of the UV Index (UVI) obtained from the ultraviolet erythemal solar radiation (UVER) data measured by the Spanish UVB Radiometric Network between the years 2000 and 2009. Previously, the daily UVI has been evaluated using two different criteria: (a) the value corresponding to solar noon; and (b) the daily maximum value. The mean percentage of agreement is 92% if we consider the cases for which the difference is zero or one UVI unit. These results are similar to those obtained in a previous work where only 2 years were analyzed. In all the stations the UVI reaches very high values (8-10) in spring-summer, and the very high and extreme (≥ 11) UVI values are more dependent on the continental effect than on the latitude effect. From the UVI values it is possible to classify the stations into four groups: Coastal stations, Continental stations (more than 200 km from the coast), Southern stations (Coastal stations but with similar values of UVI as the Continental ones due to their low latitude) and Canary Islands stations (1400 km southwest from the Iberian Peninsula thus lower latitude). The monthly mean maximum of UVI is reached in July due to the annual evolution of the total ozone column. This value corresponds, for a skin phototype II, to three times the minimal erythemal dose (MED) in an hour in a Coastal station, 3.5 MEDs in an hour measured in a Continental or Southern station and up five MEDs in an hour in the Izaña station (Canary Islands). The cumulative dose on a horizontal plane over an average year has been calculated for each station. More than 40% of the annual dose is received in summer, about 35% in spring, more than 11% in autumn and less than 10% in winter except for the stations in the Canary Islands where the difference between seasons is less significant. PMID:23685479

  18. Ten years of asthma admissions to adult critical care units in England and Wales

    PubMed Central

    Gibbison, Ben; Griggs, Kathryn; Mukherjee, Mome; Sheikh, Aziz

    2013-01-01

    Objectives To describe the patient demographics, outcomes and trends of admissions with acute severe asthma admitted to adult critical care units in England and Wales. Design 10-year, retrospective analysis of a national audit database. Setting Secondary care: adult, general critical care units in the UK. Participants 830 808 admissions to adult, general critical care units. Primary and secondary outcome measures Demographic data including age and sex, whether the patient was invasively ventilated or not, length of stay (LOS; both in the critical care unit and acute hospital), survival (both critical care unit and acute hospital) and time trends across the 10-year period. Results Over the 10-year period, there were 11 948 (1.4% of total) admissions with asthma to adult critical care units in England and Wales. Among them 67.5% were female and 32.5% were male (RR F:M 2.1; 95% CI 2.0 to 2.1). Median LOS in the critical care unit was 1.8 days (IQR 0.9–3.8). Median LOS in the acute hospital was 7 days (IQR 4–14). Critical care unit survival rate was 95.5%. Survival at discharge from hospital was 93.3%. There was an increase in admissions to adult critical care units by an average of 4.7% (95% CI 2.8 to 6.7)/year. Conclusions Acute asthma represents a modest burden of work for adult critical care units in England and Wales. Demographic patterns for admission to critical care unit mirror those of severe asthma in the general adult community. The number of critical care admissions with asthma are rising, although we were unable to discern whether this represents a true increase in the incidence of acute asthma or asthma severity. PMID:24056484

  19. Ten Years Experience With Belatacept-Based Immunosuppression After Kidney Transplantation

    PubMed Central

    Grannas, Gerrit; Schrem, Harald; Klempnauer, Juergen; Lehner, Frank

    2014-01-01

    Background Belatacept was approved for prevention of acute rejection in adult kidney transplantation in 2011 based on two randomized, controlled, multicenter phase 3 studies. Long-term experience over 10 years with belatacept-based immunosuppression after kidney transplantation has not been reported before. Patients and Methods Analyzed were 20 patients who had been included into a randomized multicenter phase 2 study by our institution between March 2001 and November 2002. For 10-year follow-up, three different groups could be analyzed: 1) patients with primary calcineurin inhibitor-based (CNI-based) immunosuppression (n = 5), 2) patients with early switch from a belatacept-based to a CNI-based regimen within the first 14 months (n = 8) and 3) patients with completely CNI-free belatacept immunosuppression (n = 7). Results Fifteen patients received primary belatacept-based immunosuppression and five patients primary cyclosporine A (CyA). Five patients are still on belatacept. Kidney function measured by serum creatinine levels worsened in the CNI group and the belatacept to CNI switch group during long-term follow-up whereas all patients receiving belatacept throughout follow-up showed stable creatinine values. Acute rejections occurred predominantly in the first 12 months after transplantation and were responsible for four of seven switches from belatacept- to CNI-based immunosuppression within the first 14 months. Five of the 20 patients died. Conclusions Belatacept is effective and safe in renal transplant patients and was not associated with graft loss due to chronic allograft nephropathy. Belatacept was well tolerated in all patients and caused less nephrotoxic side effects and was well accepted in most patients. PMID:24578751

  20. Ten-Year Recurrence Rates in Young Women With Breast Cancer by Locoregional Treatment Approach

    SciTech Connect

    Beadle, Beth M.; Woodward, Wendy A. Tucker, Susan L.; Outlaw, Elesyia D.; Allen, Pamela K.; Oh, Julia L.; Strom, Eric A.; Perkins, George H.; Tereffe, Welela; Yu, T.-K.; Meric-Bernstam, Funda; Litton, Jennifer K.; Buchholz, Thomas A.

    2009-03-01

    Purpose: Young women with breast cancer have higher locoregional recurrence (LRR) rates than older patients. The goal of this study is to determine the impact of locoregional treatment strategy, breast-conserving therapy (BCT), mastectomy alone (M), or mastectomy with adjuvant radiation (MXRT), on LRR for patients 35 years or younger. Methods and Materials: Data for 668 breast cancers in 652 young patients with breast cancer were retrospectively reviewed; 197 patients were treated with BCT, 237 with M, and 234 with MXRT. Results: Median follow-up for all living patients was 114 months. In the entire cohort, 10-year actuarial LRR rates varied by locoregional treatment: 19.8% for BCT, 24.1% for M, and 15.1% for MXRT (p = 0.05). In patients with Stage II disease, 10-year actuarial LRR rates by locoregional treatment strategy were 17.7% for BCT, 22.8% for M, and 5.7% for MXRT (p = 0.02). On multivariate analysis, M (hazard ratio, 4.45) and Grade III disease (hazard ratio, 2.24) predicted for increased LRR. In patients with Stage I disease, there was no difference in LRR rates based on locoregional treatment (18.0% for BCT, 19.8% for M; p = 0.56), but chemotherapy use had a statistically significant LRR benefit (13.5% for chemotherapy, 27.9% for none; p = 0.04). Conclusions: Young women have high rates of LRR after breast cancer treatment. For patients with Stage II disease, the best locoregional control rates were achieved with MXRT. For patients with Stage I disease, similar outcomes were achieved with BCT and mastectomy; however, chemotherapy provided a significant benefit to either approach.

  1. Ten-Year Review of Major Birth Defects in VLBW Infants

    PubMed Central

    Hansen, Nellie I.; Shankaran, Seetha; Bell, Edward F.; Boghossian, Nansi S.; Murray, Jeffrey C.; Laptook, Abbot R.; Walsh, Michele C.; Carlo, Waldemar A.; Sánchez, Pablo J.; Van Meurs, Krisa P.; Das, Abhik; Hale, Ellen C.; Newman, Nancy S.; Ball, M. Bethany; Higgins, Rosemary D.; Stoll, Barbara J.

    2013-01-01

    OBJECTIVE: Birth defects (BDs) are an important cause of infant mortality and disproportionately occur among low birth weight infants. We determined the prevalence of BDs in a cohort of very low birth weight (VLBW) infants cared for at the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN) centers over a 10-year period and examined the relationship between anomalies, neonatal outcomes, and surgical care. METHODS: Infant and maternal data were collected prospectively for infants weighing 401 to 1500 g at NRN sites between January 1, 1998, and December 31, 2007. Poisson regression models were used to compare risk of outcomes for infants with versus without BDs while adjusting for gestational age and other characteristics. RESULTS: A BD was present in 1776 (4.8%) of the 37 262 infants in our VLBW cohort. Yearly prevalence of BDs increased from 4.0% of infants born in 1998 to 5.6% in 2007, P < .001. Mean gestational age overall was 28 weeks, and mean birth weight was 1007 g. Infants with BDs were more mature but more likely to be small for gestational age compared with infants without BDs. Chromosomal and cardiovascular anomalies were most frequent with each occurring in 20% of affected infants. Mortality was higher among infants with BDs (49% vs 18%; adjusted relative risk: 3.66 [95% confidence interval: 3.41–3.92]; P < .001) and varied by diagnosis. Among those surviving >3 days, more infants with BDs underwent major surgery (48% vs 13%, P < .001). CONCLUSIONS: Prevalence of BDs increased during the 10 years studied. BDs remain an important cause of neonatal morbidity and mortality among VLBW infants. PMID:23733791

  2. Corneal Graft Rejection Ten Years after Penetrating Keratoplasty in the Cornea Donor Study

    PubMed Central

    Dunn, Steven P.; Gal, Robin L.; Kollman, Craig; Raghinaru, Dan; Dontchev, Mariya; Blanton, Christopher L.; Holland, Edward J; Lass, Jonathan H.; Kenyon, Kenneth R.; Mannis, Mark J; Mian, Shahzad I.; Rapuano, Christopher J.; Stark, Walter J.; Beck, Roy W.

    2015-01-01

    Purpose To assess the effect of donor and recipient factors on corneal allograft rejection and evaluate whether a rejection event was associated with graft failure. Methods 1,090 subjects undergoing penetrating keratoplasty for a moderate risk condition (principally Fuchs’ dystrophy or pseudophakic corneal edema) were followed for up to 12 years. Associations of baseline recipient and donor factors with the occurrence of a rejection event were assessed in univariate and multivariate proportional hazards models. Results Among 651 eyes with a surviving graft at 5 years, the 10-year graft failure (± 99% CI) rates were 12% ± 4% among eyes with no rejection events in the first 5 years, 17% ± 12% in eyes with at least one probable, but no definite rejection event, and 22% ± 20% in eyes with at least one definite rejection event. The only baseline factor significantly associated with a higher risk of definite graft rejection was a preoperative history of glaucoma, particularly when prior glaucoma surgery had been performed and glaucoma medications were being used at time of transplant (10-year incidence 35% ± 23% compared with 14% ± 4% in eyes with no history of glaucoma/intraocular pressure treatment, p=0.008). Conclusion Those patients who experienced a definite rejection event frequently went on to graft failure raising important questions as to how we might change acute and long-term corneal graft management. Multivariate analysis indicated that the prior use of glaucoma medications and glaucoma filtering surgery was a significant risk factor related to a definite rejection event. PMID:25119961

  3. Changing trends in corneal graft surgery: a ten-year review

    PubMed Central

    de Sanctis, Ugo; Alovisi, Camilla; Bauchiero, Luigi; Caramello, Guido; Girotto, Gianfranco; Panico, Claudio; Vinai, Luisa; Genzano, Federico; Amoroso, Antonio; Grignolo, Federico

    2016-01-01

    AIM To review indications and corneal tissue use for penetrating and lamellar surgery between 2002 and 2011. METHODS The surgical reports of corneal grafts performed during 2002-2011, using tissues supplied by the Eye Bank of Piedmont (Italy), were reviewed retrospectively. Patient demographic data, date of intervention, indication for surgery, and surgical technique used were recorded. Surgical techniques included penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK) and endothelial keratoplasty (EK). The χ2 test was used to compare the distribution of indications and types of surgical technique used, for corneal grafts done during 2002-2006 versus those done during 2007-2011. RESULTS The number of corneal grafts increased by 30.7% from 2002-2006 to 2007-2011 (from 1567 to 2048). Comparing the two periods, both main indications and surgical techniques changed significantly. In 2007-2011, the proportion of interventions for aphakic/pseudophakic bullous keratopathy (from 16.8% to 21.3%), graft failure (from 16.4% to 19.1%) and Fuchs endothelial dystrophy (from 12.8% to 16.7%) all increased significantly (P<0.05), while those for keratoconus decreased significantly (from 35.6% to 27.3%; P<0.001). In 2007-2011, the proportion of PK decreased significantly (from 92.4% to 57.2%; P<0.001) while that of EK and DALK went from 0.4% to 30.2% (P<0.001) and from 7.2% to 12.6% (P<0.001) respectively. CONCLUSION During 2002-2011 the number of interventions increased significantly for corneal endothelial diseases and graft failure. The growing demand for interventions for these diseases corresponded to the widespread adoption of EK techniques. The use of DALK also increased, but more moderately than EK procedures. PMID:26949609

  4. Ten-Year Cleft Surgery in Nepal: Achievements and Lessons Learned for Better Cleft Care Abroad

    PubMed Central

    Pape, Hans-Dieter; Koch, Heribert; Koller, Michael

    2016-01-01

    Background: Cleft lip and palate surgery abroad is devoid of global consensus regarding standards of therapy, follow-up, and outcome. Cleft surgery in Nepal during a 10-year sustained program provided the opportunity to inform on the need for such standards. Methods: Medical records were evaluated from the cleft clinic at Sushma Koirala Memorial Hospital, Sankhu, Kathmandu, Nepal, from 1997 to 2007. Four groups were identified for analysis: total cohort, total surgical cohort (TSC), primary program patients (PPP; patients had not been operated on before), and nonprimary program patients (non-PPP; patients operated on elsewhere before). Patient demographics, diagnostic, primary and secondary surgery (corrective surgery), and follow-up were evaluated. Results: One thousand forty-five patients were eligible for surgery. Three hundred twenty-three of 1,045 patients (30.9%) did not seek treatment, although scheduled for surgery. One thousand two hundred one procedures were performed in 722 patients [TSC; 845 PPP (70.4%); 356 non-PPP (29.64%)]. Corrective procedures were performed in 257 of 1,201 [3.5% (30 of 845 procedures in 509 patients) PPP vs 63.7% (227 of 356 procedures in 213 patients) non-PPP]. One hundred six lips were completely reoperated on (1 PPP vs 105 non-PPP), and 42 palates underwent a total revision (5 PPP vs 37 non-PPP). The surgical outcome of the TSC group in terms of complication rate was similar to the one in developed countries. Conclusions: The high rate of corrective surgery reveals the need for global regulatory mechanisms and the need for nongovernmental organizations to introduce strategies for delivering sustained cleft care until achieving full rehabilitation. The World Health Organization should establish standards for cleft care delivered in less developed countries. PMID:27579235

  5. Ten-Year Follow-up of Patients with Epidemic Post Infectious Glomerulonephritis

    PubMed Central

    Pinto, Sergio Wyton L.; Mastroianni-Kirsztajn, Gianna; Sesso, Ricardo

    2015-01-01

    Background Scarce information on outcomes of epidemic post infectious glomerulonephritis is available. This is a 10-year follow-up of the patients that developed acute glomerulonephritis in an epidemic outbreak caused by group C Streptococcus zooepidemicus in Brazil in 1998, that were also previously evaluated 2 and 5 years after the acute episode. Methods In this prospective study 60 cases (out of 134 in 1998) were reevaluated after 10 years, as well as community controls matched by gender and age. They underwent clinical and renal function evaluation, including serum creatinine and cystatin C, estimated glomerular filtration rate (eGFR), albuminuria and hematuria. Results Comparisons of clinical and renal function aspects of 60 patients and 48 community controls have not shown significant differences (eGFR <60 ml/min/1.73m2 and/or albuminuria >30mg/g creatinine: 13.8% vs. 12.2%, respectively, p = 0.817) except for a higher frequency of hypertension in the cases (45.0% vs. 20.8%, p = 0.009). Comparing the same patients affected in the acute episode, 2, 5 and 10 years later, it was observed an improvement of median eGFR levels at 2 years and a trend toward subsequent stabilization in these levels, associated with decrease in albuminuria and increased hypertension rates in the last survey. At 10 years it was not observed additional reduction of renal function using serum creatinine, eGFR and cystatin C. Conclusions During the acute episode of epidemic GN a considerable proportion of patients presented hypertension and reduced renal function; after 2 years and particularly at this 10-year follow-up survey there was no worsening of renal function parameters, except for persistent higher frequency of hypertension. Nevertheless, a longer follow up is necessary to confirm that progressive loss of renal function will not occur. PMID:25962068

  6. Social support, depression, and heart disease: a ten year literature review

    PubMed Central

    Compare, Angelo; Zarbo, Cristina; Manzoni, Gian Mauro; Castelnuovo, Gianluca; Baldassari, Elena; Bonardi, Alberto; Callus, Edward; Romagnoni, Claudia

    2013-01-01

    Background: Coronary heart disease is the major cause of morbidity and mortality in the world. Psychosocial factors such as depression and low social support are established risk factors for poor prognosis in patients with heart disease. However, little is known about the hypothetical relationship pattern between them. Purpose: The purposes of this narrative review are (1) to appraise the 2002–2012 empirical evidence about the multivariate relationship between depression, social support and health outcomes in patients with heart disease; (2) to evaluate the methodological quality of included studies. Method: PubMed and PsychINFO were searched for quantitative studies assessing the multiple effects of low social support and depression on prognosis outcomes in patients with heart disease. The following search terms were used: social relation*, cardiac disease, support quality, relationship, and relational support. Results: Five studies (three prospective cohort studies, one case-control study, and one randomization controlled trial) were selected and coded according to the types of support (social and marital). The majority of findings suggests that low social support/being unmarried and depression are independent risk factors for poor cardiac prognosis. However, all analyzed studies have some limitations. The majority of them did not focus on the quality of marital or social relationships, but assessed only the presence of marital status or social relationship. Moreover, some of them present methodological limitations. Conclusion: Depressive symptoms and the absence of social or marital support are significant risk factors for poor prognosis in cardiac patients and some evidence supports their independence in predicting adverse outcomes. Cardiac rehabilitation and prevention programs should thus include not only the assessment and treatment of depression but also a specific component on the family and social contexts of patients. PMID:23847561

  7. Ten-year experience in management of diabetic ketoacidosis and ketosis: 140 episodes at pediatric age.

    PubMed

    Yordam, Nuren; Gönç, E Nazli; Kandemir, Nurgün; Alikaşifoğlu, Ayfer; Ozön, Alev

    2005-01-01

    One hundred and forty episodes in 112 patients (58 boys) with diabetic ketoacidosis (96 episodes) and diabetic ketosis (44 episodes) were studied to elucidate the clinical and laboratory risk factors for altered level of consciousness at presentation and to analyze the outcome of a distinct protocol in the treatment of diabetic ketoacidosis. The patients were analyzed according to demographic data and clinical and laboratory findings at admission. The treatment protocol involved use of 0.45% sodium chloride (NaCl) in 2.5% dextrose as the initial fluid therapy following volume expansion. Dextrose content of the fluid was doubled once the serum glucose level fell below 250 mg/dl. The mean ages at presentation with diabetic ketoacidosis and ketosis were 10.3 +/- 4.4 and 10.2 +/- 4.0 years, respectively. Thirty-one percent of patients had altered consciousness at presentation. The level of consciousness correlated negatively with serum bicarbonate level (r=-0.485; p<0.001). A serum bicarbonate level below 15 mmol/L was a risk factor for altered consciousness. There was no correlation between effective osmolality and the level of consciousness. Serum effective osmolality above 320 mOsm/kg H2O did not appear to be a risk factor for altered consciousness. No mortality or any signs of clinical brain edema were observed in patients treated with the distinct treatment protocol. In conclusion, acidosis appears to be the major factor in the pathogenesis of altered consciousness at presentation. Serum effective osmolality does not seem to be a risk factor as suggested previously. Dextrose added to the infusion fluid early in treatment seems to prevent the development of brain edema, and this may be due to a protective effect of higher osmolality in the resultant solution. PMID:16363342

  8. Shigellosis in the United States: ten-year review of nationwide surveillance, 1964-1973.

    PubMed

    Rosenberg, M L; Weissman, J B; Gangarosa, E J; Reller, L B; Beasley, R P

    1976-11-01

    In the 10 years 1964-1973, 105,832 isolations of shigellae were reported to the Center for Disease Control through a nationwide surveillance system. The number reported increased by approximately 13% annually, from 5852 in 1964, when only 17 centers reported all 4 quarters; to 16,797 in 1973, when 52 centers reported each quarter. The rate of reported isolations varied from 4.6 per 100,000 persons in 1965 to 9.1 per 100,000 in 1973. Shigella sonnei accounted for 64% of all these isolates and for more than 80% of isolates in 1973. The majority of reported cases of shigellosis occurred in young children and in women of childbearing age. During the 10-year surveillance period, 35 epidemics in 25 states were investigated. Two-thirds of these outbreaks were the result of person-to-person spread; investigations of common-source outbreaks showed the importance of both water and foodstuffs, especially salads, as potential vehicles of contamination. Indian reservations, custodial institutions, and day-care centers were identified as special high-risk settings for the transmission of shigellosis. The emergence of R-factor-mediated antimicrobial-resistance patterns in recent years has necessitated antibiotic sensitivity testing to determine the drug of choice for treatment of individual cases. Initial testing of oral vaccines suggests these vaccines will have only limited usefulness in protecting certain high-risk populations. Public health education coupled with improvements in water and sewerage systems remains the most satisfactory means of control. PMID:790947

  9. Ten-Year Experience of Cutaneous and/or Subcutaneous Infections Due to Coelomycetes in France

    PubMed Central

    Guégan, Sarah; Garcia-Hermoso, Dea; Sitbon, Karine; Ahmed, Sarah; Moguelet, Philippe; Dromer, Françoise; Lortholary, Olivier

    2016-01-01

    Background. Coelomycetes are rarely but increasingly reported in association with human infections involving mostly skin and subcutaneous tissues, both in immunocompetent and immunocompromised patients. Coelomycetes constitute a heterogeneous group of filamentous fungi with distinct morphological characteristics in culture, namely an ability to produce asexual spores within fruit bodies. Methods. We included all cases of proven primary cutaneous and/or subcutaneous infections due to coelomycetes received for identification at the French National Reference Center for Invasive Mycoses and Antifungals between 2005 and 2014. Eumycetoma, chromoblastomycosis, and disseminated infections were excluded. Results. Eighteen cases were analyzed. The median age was 60.5 years. In all cases, patients originated from tropical or subtropical areas. An underlying immunodepression was present in 89% of cases. Cutaneous and/or subcutaneous lesions, mainly nodules, abscesses, or infiltrated plaques, were observed in distal body areas. Isolates of different genera of coelomycetes were identified: Medicopsis (6), Paraconiothyrium (3), Gloniopsis (3), Diaporthe (3), Peyronellaea (2), Lasiodiplodia (1). Lesion treatment consisted of complete (10) or partial (2) surgical excision and/or the use of systemic antifungal therapy, namely voriconazole (5) and posaconazole (4). Literature review yielded 48 additional cases of cutaneous and/or subcutaneous infections due to coelomycetes. Conclusions. Infectious diseases physicians should suspect coelomycetes when observing cutaneous and/or subcutaneous infections in immunocompromised hosts from tropical areas; a sequence-based approach is crucial for strains identification but must be supported by consistent phenotypic features; surgical treatment should be favored for solitary, well limited lesions; new triazoles may be used in case of extensive lesions, especially in immunocompromised patients. PMID:27419178

  10. Ten-Year Experience of Cutaneous and/or Subcutaneous Infections Due to Coelomycetes in France.

    PubMed

    Guégan, Sarah; Garcia-Hermoso, Dea; Sitbon, Karine; Ahmed, Sarah; Moguelet, Philippe; Dromer, Françoise; Lortholary, Olivier

    2016-04-01

    Background.  Coelomycetes are rarely but increasingly reported in association with human infections involving mostly skin and subcutaneous tissues, both in immunocompetent and immunocompromised patients. Coelomycetes constitute a heterogeneous group of filamentous fungi with distinct morphological characteristics in culture, namely an ability to produce asexual spores within fruit bodies. Methods.  We included all cases of proven primary cutaneous and/or subcutaneous infections due to coelomycetes received for identification at the French National Reference Center for Invasive Mycoses and Antifungals between 2005 and 2014. Eumycetoma, chromoblastomycosis, and disseminated infections were excluded. Results.  Eighteen cases were analyzed. The median age was 60.5 years. In all cases, patients originated from tropical or subtropical areas. An underlying immunodepression was present in 89% of cases. Cutaneous and/or subcutaneous lesions, mainly nodules, abscesses, or infiltrated plaques, were observed in distal body areas. Isolates of different genera of coelomycetes were identified: Medicopsis (6), Paraconiothyrium (3), Gloniopsis (3), Diaporthe (3), Peyronellaea (2), Lasiodiplodia (1). Lesion treatment consisted of complete (10) or partial (2) surgical excision and/or the use of systemic antifungal therapy, namely voriconazole (5) and posaconazole (4). Literature review yielded 48 additional cases of cutaneous and/or subcutaneous infections due to coelomycetes. Conclusions.  Infectious diseases physicians should suspect coelomycetes when observing cutaneous and/or subcutaneous infections in immunocompromised hosts from tropical areas; a sequence-based approach is crucial for strains identification but must be supported by consistent phenotypic features; surgical treatment should be favored for solitary, well limited lesions; new triazoles may be used in case of extensive lesions, especially in immunocompromised patients. PMID:27419178

  11. Primary Dental Care 1994-2004: the first ten years. A chronology.

    PubMed

    Renson, Ted

    2004-10-01

    The prime purpose of a professional journal is to keep its readers informed of changes of importance affecting the practise of that profession. That is the criterion that I have applied in producing this chronology of the papers that have been published in Primary DENTAL CARE during the past decade. The ambition which has guided me since I received the invitation to carry out this review is a simple one: to include as much as may generally be found useful by general dental practitioners (GDPs), who form the bulk of our readership. In 1789 the English philosopher Jeremy Bentham extolled the virtues of utility for mankind when he declared that 'the greatest happiness of the greatest number is the foundation of morals and legislation'. The contributors that I have included, by contrast, think of their utilitarianism as striving after the most practical. The principal purpose of this chronology is to achieve a summary, without weighing causes or consequences. From past experience, an outstanding virtue of such an aggregated record is that it can inspire fresh patterns of thought and thus encourage the submission of manuscripts as a result of those thoughts. I can think of scarcely any facet of the general practice of dentistry that has not been touched upon, for the most part authoritatively. I hope that these brief aide-memoires may persuade old readers to return to those articles of particular interest to them and that new readers will feel informed about past papers. Every issue of the journal to date has been reviewed. Dates, volume and issue numbers and principal authors' names are all included. With these identifying features any paper, to which reference is made, may be quickly found. It would be manifestly absurd to use precious space on a formal listing of more than 250 references and this listing has, therefore, been omitted. PMID:15509435

  12. Ten Years Experience In Geo-Databases For Linear Facilities Risk Assessment (Lfra)

    NASA Astrophysics Data System (ADS)

    Oboni, F.

    2003-04-01

    Keywords: geo-environmental, database, ISO14000, management, decision-making, risk, pipelines, roads, railroads, loss control, SAR, hazard identification ABSTRACT: During the past decades, characterized by the development of the Risk Management (RM) culture, a variety of different RM models have been proposed by governmental agencies in various parts of the world. The most structured models appear to have originated in the field of environmental RM. These models are briefly reviewed in the first section of the paper focusing the attention on the difference between Hazard Management and Risk Management and the need to use databases in order to allow retrieval of specific information and effective updating. The core of the paper reviews a number of different RM approaches, based on extensions of geo-databases, specifically developed for linear facilities (LF) in transportation corridors since the early 90s in Switzerland, Italy, Canada, the US and South America. The applications are compared in terms of methodology, capabilities and resources necessary to their implementation. The paper then focuses the attention on the level of detail that applications and related data have to attain. Common pitfalls related to decision making based on hazards rather than on risks are discussed. The paper focuses the last sections on the description of the next generation of linear facility RA application, including examples of results and discussion of future methodological research. It is shown that geo-databases should be linked to loss control and accident reports in order to maximize their benefits. The links between RA and ISO 14000 (environmental management code) are explicitly considered.

  13. Taking stock of herbicide-resistant crops ten years after introduction.

    PubMed

    Duke, Stephen O

    2005-03-01

    Since transgenic, bromoxynil-resistant cotton and glufosinate-resistant canola were introduced in 1995, planting of transgenic herbicide-resistant crops has grown substantially, revolutionizing weed management where they have been available. Before 1995, several commercial herbicide-resistant crops were produced by biotechnology through selection for resistance in tissue culture. However, non-transgenic herbicide-resistant crops have had less commercial impact. Since the introduction of glyphosate-resistant soybean in 1996, and the subsequent introduction of other glyphosate-resistant crops, where available, they have taken a commanding share of the herbicide-resistant crop market, especially in soybean, cotton and canola. The high level of adoption of glyphosate-resistant crops by North American farmers has helped to significantly reduce the value of the remaining herbicide market. This has resulted in reduced investment in herbicide discovery, which may be problematic for addressing future weed-management problems. Introduction of herbicide-resistant crops that can be used with selective herbicides has apparently been hindered by the great success of glyphosate-resistant crops. Evolution of glyphosate-resistant weeds and movement of naturally resistant weed species into glyphosate-resistant crop fields will require increases in the use of other herbicides, but the speed with which these processes compromise the use of glyphosate alone is uncertain. The future of herbicide-resistant crops will be influenced by many factors, including alternative technologies, public opinion and weed resistance. Considering the relatively few recent approvals for field testing new herbicide-resistant crops and recent decisions not to grow glyphosate-resistant sugarbeet and wheat, the introduction and adoption of herbicide-resistant crops during the next 10 years is not likely to be as dramatic as in the past 10 years. PMID:15660452

  14. Ten Take Home Lessons from the First Ten Years of the CTN and Ten Recommendations for the Future

    PubMed Central

    Carroll, Kathleen M.; Ball, Samuel A.; Jackson, Ron; Martino, Steve; Petry, Nancy M.; Stitzer, Maxine L.; Wells, Elizabeth A.; Weiss, Roger D.

    2011-01-01

    The first ten years of the National Institute on Drug Abuse’s Clinical Trials Network (CTN) yielded a wealth of data on the effectiveness of a number of behavioral, pharmacologic, and combined approaches in community based settings. As an introduction to this Special Issue on the CTN, we summarize some of the methodological contributions and lessons learned from the behavioral trials conducted during its first ten years, including the capacity and enormous potential of this national research infrastructure; contributions to the methodology of effectiveness research; new insights from secondary analyses; the extent to which approaches with strong evidence bases, such as contingency management, extend their effectiveness to real world clinical settings; new data on ‘standard treatment’ as actually practiced in community programs, the extent to which retention remains a major issue in the field; important data on the safety of specific behavioral therapies for addiction; and heightened the importance of continued sustained attention to bridging the gap between treatment and research. Possible areas of focus for the CTN’s future include defining common outcome measures to be used in treatment outcome studies for illicit drugs; incorporating performance indicators and measures of clinical significance; conducting comparative outcome studies; contributing to the understanding of effective treatments of comorbidity; reaching underserved populations; building implementation science; understanding long-term outcomes of current treatments and sustaining treatment effects; and conducting future trials more efficiently. PMID:21854269

  15. Incidence of primary breast cancer in Iran: Ten-year national cancer registry data report.

    PubMed

    Jazayeri, Seyed Behzad; Saadat, Soheil; Ramezani, Rashid; Kaviani, Ahmad

    2015-08-01

    Breast cancer is the leading type of malignancy and the leading cause of cancer-related deaths in women worldwide. The screening programs and advances in the treatment of patients with breast cancer have led to an increase in overall survival. Cancer registry systems play an important role in providing basic data for research and the monitoring of the cancer status. In this study, the results of the 10-year national cancer registry (NCR) of Iran in breast cancer are reviewed. NCR database records were searched for primary breast cancer records according to ICD-O-3 coding and the cases were reviewed. A total of 52,068 cases were found with the coding of primary breast cancer. Females constituted 97.1% of the cases. Breast cancer was the leading type of cancer in Iranian females, accounting for 24.6% of all cancers. The mean age of the women with breast cancer was 49.6 years (95%CI 49.5-49.6). Most of the cases (95.7%) were registered as having invasive pathologies (behavior code 3). The most common morphology of primary breast cancer was invasive ductal carcinoma (ICD-O 8500/3) followed by invasive lobular carcinoma (ICD-O 8520/3) with relative frequencies of 77.8% and 5.2%, respectively. The average annual crude incidence of primary breast cancer in females was 22.6 (95%CI 22.1-23.1) per 100,000 females, with an age-standardized rate (ASR) of 27.4 (95%CI 22.5-35.9). There were no data on survival, staging or immunohistochemical marker(s) of the breast-cancer-registered cases. The incidence of breast cancer in Iran is lower than in low-middle-income neighboring countries. The NCR data registry of breast cancer is not accurate in monitoring the effect of screening programs or determining the current status of breast cancer in Iran. Screening programs of breast cancer in Iran have failed to enhance the detection of the patients with in situ lesion detection. A quality breast cancer registry and a screening program for breast cancer are both needed. PMID:26070507

  16. Kicking Back Cognitive Ageing: Leg Power Predicts Cognitive Ageing after Ten Years in Older Female Twins

    PubMed Central

    Steves, Claire J.; Mehta, Mitul M.; Jackson, Stephen H.D.; Spector, Tim D.

    2016-01-01

    Background Many observational studies have shown a protective effect of physical activity on cognitive ageing, but interventional studies have been less convincing. This may be due to short time scales of interventions, suboptimal interventional regimes or lack of lasting effect. Confounding through common genetic and developmental causes is also possible. Objectives We aimed to test whether muscle fitness (measured by leg power) could predict cognitive change in a healthy older population over a 10-year time interval, how this performed alongside other predictors of cognitive ageing, and whether this effect was confounded by factors shared by twins. In addition, we investigated whether differences in leg power were predictive of differences in brain structure and function after 12 years of follow-up in identical twin pairs. Methods A total of 324 healthy female twins (average age at baseline 55, range 43-73) performed the Cambridge Neuropsychological Test Automated Battery (CANTAB) at two time points 10 years apart. Linear regression modelling was used to assess the relationships between baseline leg power, physical activity and subsequent cognitive change, adjusting comprehensively for baseline covariates (including heart disease, diabetes, blood pressure, fasting blood glucose, lipids, diet, body habitus, smoking and alcohol habits, reading IQ, socioeconomic status and birthweight). A discordant twin approach was used to adjust for factors shared by twins. A subset of monozygotic pairs then underwent magnetic resonance imaging. The relationship between muscle fitness and brain structure and function was assessed using linear regression modelling and paired t tests. Results A striking protective relationship was found between muscle fitness (leg power) and both 10-year cognitive change [fully adjusted model standardised β-coefficient (Stdβ) = 0.174, p = 0.002] and subsequent total grey matter (Stdβ = 0.362, p = 0.005). These effects were robust in discordant

  17. Ten years' experience using an integrated workers' compensation management system to control workers' compensation costs.

    PubMed

    Bernacki, Edward J; Tsai, Shan P

    2003-05-01

    This work presents 10 years of experience using an Integrated Workers' Compensation Claims Management System that allows safety professionals, adjusters, and selected medical and nursing providers to collaborate in a process of preventing accidents and expeditiously assessing, treating, and returning individuals to productive work. The hallmarks of the program involve patient advocacy and customer service, steerage of injured employees to a small network of physicians, close follow-up, and the continuous dialogue between parties regarding claims management. The integrated claims management system was instituted in fiscal year 1992 servicing a population of approximately 21,000 individuals. The system was periodically refined and by the 2002 fiscal year, 39,000 individuals were managed under this paradigm. The frequency of lost-time and medical claims rate decreased 73% (from 22 per 1000 employees to 6) and 61% (from 155 per 1000 employees to 61), respectively, between fiscal year 1992 and fiscal year 2002. The number of temporary/total days paid per 100 insureds decreased from 163 in fiscal year 1992 to 37 in fiscal year 2002, or 77%. Total workers' compensation expenses including all medical, indemnity and administrative, decreased from $0.81 per $100 of payroll in fiscal year 1992 to $0.37 per $100 of payroll in fiscal year 2002, a 54% decrease. More specifically, medical costs per $100 of payroll decreased 44% (from $0.27 to $0.15), temporary/total, 61% (from $0.18 to $0.07), permanent/partial, 63% (from $0.19 to $0.07) and administrative costs, 48% ($0.16 to $0.09). These data suggests that workers' compensation costs can be reduced over a multi-year period by using a small network of clinically skilled health care providers who address an individual workers' psychological, as well as physical needs and where communication between all parties (e.g., medical care providers, supervisors, and injured employees) is constantly maintained. Furthermore, these results

  18. Ten Years of Chandra

    NASA Technical Reports Server (NTRS)

    Weisskopf, Martin C.

    2009-01-01

    We celebrated the 10-th anniversary of the Launch of the Chandra X-ray Observatory on July 13, 2009. During these 10 years data from this Great Observatory have had a profound impact on 21st century astrophysics. With its unrivaled capability to produce sub-arcsecond images, the Observatory has enabled astronomers to make new discoveries in topics as diverse as comets and cosmology. We shall review some of the highlights, discuss the current status, and future plans.

  19. Ten years after Chernobyl

    SciTech Connect

    Becker, K.

    1996-12-31

    As was amply demonstrated during the EU/IAEA/WHO Summing-up-Conference in Vienna, Austria, April 8-12, 1996, the radiological consequences of the Chernobyl accident were, fortunately, not as serious as frequently presented in the media: 28 people died from acute radiation syndrome in 1986, 14 more of possibly radiation-related causes since. Of the <1000 thyroid cancers in children, 90 to 95% are curable. There have so far been no other demonstrable increases in the former Soviet Union, as well as in Western Europe, of leukemias, solid cancers, or genetic defects, nor are any to be expected in the future. Even among the {open_quotes}liquidators{close_quotes} with doses {approximately}100 mSv, of the {approximately}150 additional expected leukemias during the 10 yr after the accident, none have been observed. The economical, social, and political consequences, however, both in the former Soviet Union and in Western Europe, have been very substantial. Whole countries developed an hysterical `radiation sickness.` As A. Merkel, the German Minister of Environment and Reactor Safety, who chaired the conference, pointed out, `the radiation sensitivity of societies far exceeds that of individuals.` It is obvious that important groups in Ukraine, Belaurus, and Russia try to blame a large fraction of all economic, social, and health problems during the last decade, which are substantial ({approx} 6 yr less life expectancy, twice the homicides and traffic deaths, increased alcoholism, and so forth), on radiation of the Chernobyl accident in an effort to attract more support. Western scientists refute such claims but admit large non-radiation-related problems caused by the accident.

  20. ESEA Ten Years Later

    ERIC Educational Resources Information Center

    Halperin, Samuel

    1975-01-01

    Achievements cited for ESEA include that it broke the log jam on federal aid to education, spotted the needs of children, fueled other movements toward equality of educational opportunity, recruited quality personnel, promoted public-nonpublic cooperation, promoted parental and community involvement, and the evaluation/accountability movement.…

  1. [Burnout : ten years later.].

    PubMed

    Bibeau, G

    1985-01-01

    The important literature on burn-out or professionnal exhaustion is examined here from three aspects: socio-cultural anthropology, biological anthropology and ethnopsychiatry. On the socio-cultural level, the emergence of burn-out is seen as an epiphenomenon arising conjointly from a new work ethic and a new concept of the person; on the biological level, the burnout is presented in relation to two main areas of study: as an adaptative strategy used by individuals to face particularly demanding situations in their working environment and as a particular modality of the interrelations between physical, psychological and behavioral dimensions in a person; on the ethnopsychiatric level, the burn-out is not interpreted as a new category in the description of illnessess but rather as a model of behavior more socially accepted and as an integrative concept that allows one to give meaning to a diversified group of symptoms. Studies on burn-out indicators, their causes, its neuro-physiology and its definition are explicitly discussed according to three perspectives: socio-cultural, biological and ethnopsychiatric. PMID:17093512

  2. Endovascular treatment of false-aneurysm ten years after dacron patch aortoplasty for coarctation of the aortic isthmus. Report of a case.

    PubMed

    Illuminati, Giulio; Pacilè, Maria Antonietta; Palumbo, Piergaspare; Salvatori, Filippo Maria; Vietri, Francesco

    2013-01-01

    False aneurysm degeneration is a known complication of patch aortoplasty for coarctation of the aortic isthmus. Open surgical treatment consists of prosthetic graft repair of the involved aorta, often requires circulatory arrest to achieve a safe proximal aortic control and perform proximal anastomosis, and finally is associated with substantial perioperative morbidity. Endografting of the diseased aorta is a valuable alternative to open repair, when feasible, with good short and long term results. We now report one more case of false aneurysm ten years after Dacron patch aortoplasty for isthmic coarctation in a 26-year-old woman, successfully treated by endovascular repair via the left common iliac artery, and a complete exclusion of the aneurysm at two year follow-up. PMID:23080212

  3. The Asia Pacific Academic Consortium for Public Heath (APACPH) the first ten years, from 1984 to 1994.

    PubMed

    Michael, J M

    2005-01-01

    In January of 1984, five deans of schools of public health from Asia and the Pacific came together on the island of Kauai in Hawaii to formally establish the Consortium. The Consortium owes its cohesive strength through those first ten years of operation, to the dedicated faculty members in the fields of public health and community medicine whose overarching desire has been to seek representation of academic public health in the health decision making process affecting the positive promotion of health. By 1994 the Consortium found itself recognized on a world wide basis in the field of global health with what was described as having: "A great potential for extending the effectiveness of community and public health". "The author, a founding Dean feels that the Consortium's commitment is to shape rather than to await the future of health status improvement for the citizens of the Asia-Pacific region. PMID:16425648

  4. Characteristics of staff victims of patient assault: ten year analysis of the Assaulted Staff Action Program (ASAP).

    PubMed

    Flannery, R B; Stone, P; Rego, S; Walker, A P

    2001-01-01

    Patient assaults on staff have been a continuing risk for inpatient and community-based psychiatric healthcare providers. This study presents a ten-year analysis of the characteristics of staff victims of patient assaults in one public mental health system of care, a period which included the transition to managed care initiatives within this system. Assault data was gathered within the context of the Assaulted Staff Action Program (ASAP), a voluntary, system-wide, peer-help, crisis intervention program that is designed to assist employees with the psychological sequelae of these patient events. In general, the findings were consistent with previously reported inpatient and community studies. Less experienced, less formally trained employees remain at high risk. The impact of managed care initiatives was found in community residences where younger female staff were most at risk. The implications of the findings and possible risk management strategies are discussed. PMID:11467157

  5. Ten-year trends in HIV prevalence among visitors to public health centers under the National HIV Surveillance System in Korea, 2000 to 2009

    PubMed Central

    2012-01-01

    Background Korea saw a sharp increase in HIV diagnosis from 2000. This serious public health concern must be monitored diligently. We identified the characteristics and trends in HIV prevalence among visitors to public health centers (PHCs) from 2000 to 2009. Methods We retrieved ten-year data of HIV tests from 253 PHCs. The HIV prevalence was analyzed by gender, age, nationality, region, and reason for HIV testing. Data were analyzed using logistic regression and score test for trend. Results HIV prevalence among PHCs’ visitors has rapidly increased for six years since 2000, decreased from 2006, and then remained stable. Approximately 50% of total HIV tests were performed for sexually transmitted infection risk group (STI RG), who were tested 1.4 times within a year. Women and the 20s comprised approximately 70% and 40% of PHCs’ visitors, respectively. The prevalence of voluntary test takers was the highest and showed most rapid increase (P = 0.007), but that of prisoners declined (P = 0.003). The prevalence of STI RG was lower than those of the other groups and remained stable throughout the ten-year period (P = 0.606). Percentage of anonymous tests was 2–3% of a total HIV tests, but overall HIV-positive rate showed a rapid increase (P < 0.001). Conclusions As voluntary or anonymous testing groups are actively engaged in learning their status of HIV, these groups showed the highest in HIV infection. Groups in the population with these characteristics should be located and encouraged to be tested, and offered anonymity. This study suggests that it is important to ascertain the characteristics of people choosing to take voluntary testing. PMID:23020818

  6. Epidemiological Study of RRT-Treated ESRD in Nanjing - A Ten-Year Experience in Nearly Three Million Insurance Covered Population

    PubMed Central

    Han, Yu-Chen; Huang, Han-Ming; Sun, Ling; Tan, Chao-Ming; Gao, Min; Liu, Hong; Tang, Ri-Ning; Wang, Yan-Li; Wang, Bei; Ma, Kun-Ling; Liu, Bi-Cheng

    2016-01-01

    Background The growing burden of end-stage renal disease (ESRD) has been a great challenge to the health care system of China. However, the exact epidemiological data for ESRD in China remain unclear. We aimed to investigate the epidemiology of ESRD treated by renal replacement therapy (RRT) in Nanjing based on analysing ten-year data of Nanjing three million insurance covered population. Methods Using the electronic registry system of Urban Employee Basic Medical Insurance (UEBMI), we included all subjects insured by UEBMI in Nanjing from 2005 to 2014 and identified subjects who developed ESRD and started RRT in this cohort. Results The UEBMI population in Nanjing increased from 1,301,882 in 2005 to 2,921,065 in 2014, among which a total of 5,840 subjects developed ESRD and received RRT. Over the 10-year period, the adjusted incidence rates of RRT in the UEBMI cohort gradually decreased from 289.3pmp in 2005 to 218.8pmp in 2014. However, the adjusted prevalence rate increased steadily from 891.7pmp in 2005 to 1,228.6pmp in 2014. The adjusted annual mortality rate decreased from 138.4 per 1000 patient-years in 2005 to 97.8 per 1000 patient-years in 2014. The long-term survival rate fluctuated over the past decade, with the 1-year survival rate ranging from 85.1% to 91.7%, the 3-year survival rate from 69.9% to 78.3% and the 5-year survival rate from 58% to 65.4%. Conclusion Nanjing is facing an increasing burden of ESRD with its improvement of medical reform. The ten-year complete registry data on RRT in urban employees in Nanjing provided a unique opportunity to understand the real threat of ESRD confronting China during its process of health care transition. PMID:26889828

  7. [1984-1994: Ten years of skin flaps. Development of transfer techniques. New methods of autoplasty described during this period].

    PubMed

    Martin, D

    1995-10-01

    Ten years of flaps represent a little and a lot. It is little compared to the 2600 years since the first flap in plastic surgery: the Susruta Indian flap, but it is a lot in view of the phenomenal acceleration of this speciality since the Second World War. In 1994 alone, more than two hundred references are listed under the heading "new flaps". As it is impossible to be exhaustive, the author has chosen to focus on two main aspects: a theoretical review of new transfer techniques, dealing successively with: the principles of reverse flow flaps, venous flaps, neurocutaneous flaps, so-called "extracorporeal" transfers, reverse flow YV technique; and practical aspects based on a review of eighteen autoplasties or donor sites selected for their surgical value, their reproductibility and their innovative nature. The author's objective is not to present a technical treatise, but rather to make the reader aware of several key points or even, in some cases, the very existence of these autoplasties. This paper is designed to be didactic, with extensive references, in order to act as a practical guide. It also demonstrates, as if there were any need, to what extent plastic surgery is able to create new solutions and the essential value of continuing research. PMID:8579301

  8. My Journey as a Surgeon-Scientist Ten Years after Receiving the Inaugural Jacobson Promising Investigator Award.

    PubMed

    Longaker, Michael T

    2015-10-01

    The First Joan L and Julius H Jacobson Promising Investigator Awardee, Michael T Longaker MD, FACS In 2005, the research committee of the American College of Surgeons was tasked with selecting the recipient of a newly established award, "The Joan L and Julius H Jacobson Promising Investigator Award." According to the Jacobsons, the $30,000 award funded by Dr Jacobson should be given at least once every 2 years to a surgeon investigator at "the tipping point," who can demonstrate that his/her research shows the promise of leading to a significant contribution to the practice of surgery and patient safety. Every year, the research committee receives many excellent nominations and has the difficult task of selecting 1 awardee. In 2005, the awardee was a young promising investigator, Michael T Longaker, MD, FACS. Ten years later, Dr Longaker, a prominent researcher in the field of "scar formation," presents his journey in research and the impact of the Jacobson award on his career. Dr Longaker is now a national and international figure in the field of wound healing, tissue regeneration, and stem cell research. Kamal MF Itani, MD, FACS and Gail Besner, MD, FACS, on behalf of the Research Committee of the American College of Surgeons. PMID:26304185

  9. Ten-Year Trends In Treatment Services For Children With Attention Deficit Hyperactivity Disorder Enrolled In Medicaid.

    PubMed

    Hoagwood, Kimberly E; Kelleher, Kelly; Zima, Bonnie T; Perrin, James M; Bilder, Scott; Crystal, Stephen

    2016-07-01

    Closing the gap between evidence-based clinical practice standards and their inclusion in routine practice continues to be a major goal of health policy reforms. This gap is especially large for the care of children with psychiatric disorders-especially those from low-income families, many of whom are insured through Medicaid. To address this gap, we analyzed trends over ten years (2001-10) from Medicaid claims data describing changes over time in medication, psychotherapy, and combined treatment services for children diagnosed with attention deficit hyperactivity disorder (ADHD). Over this time, more children received treatments that conformed to practice standards, including the use of combination treatments of medication and psychotherapy. Rates of combined treatment increased by 74 percent, rates of psychotherapy alone more than doubled, and rates of medication alone decreased by 18 percent. Rates of diagnoses without any reimbursed treatment decreased by 39 percent. These trends suggest increasing adherence to clinical practice standards by providers serving children with ADHD in the Medicaid population, although the quality of those services is unknown. PMID:27385243

  10. Penile cutaneous horn ten years after treatment of verrucous squamous cell carcinoma on penile glans: case report.

    PubMed

    Mokos, Ivica; Bukvić Mokos, Zrinka; Ljubojević, Suzana; Corić, Marijana; Grce, Magdalena; Michal, Michal

    2012-01-01

    Penile cutaneous horn is a clinical term that describes protruding hyperkeratosis, usually conical in shape, located on penile glans. Penile localization of this lesion, predominantly located on sun-exposed areas, is very rare. The association with malignancy on the penis makes proper identification of these lesions essential. We present a 45-year-old man with a cutaneous horn, 25 mm in size, located on the basis of penile glans. The patient had a history of phimosis, pseudoepitheliomatous balanoposthitis, surgical excision of penile verrucous squamous cell carcinoma (SCC) and postoperative radiotherapy of carcinoma in situ on the same localization, ten years before. Complete surgical removal of the horn with separate excision of the margins and base was done. Pathologic examination revealed squamous hyperplasia with suspicion of carcinoma in situ. Additional negative p16(INK4a) immunohistochemical analysis confirmed benign proliferative lesion. DNA polymerase chain reaction for human papilloma virus infection was negative. These findings suggested sparing surgical procedure in our patient, without indication for partial penile amputation, but with mandatory follow-up. Our case confirmed the association of pseudoepitheliomatous balanoposthitis with verrucous SCC, as well as the possible influence of radiotherapy on the development of penile cutaneous horn. Additionally, we showed the important role p16(INK4a) immunohistochemical analysis in the differential diagnosis of alterations adjacent to invasive SCC of the penis. PMID:22507472

  11. Ten-year longitudinal study of the effect of impulse noise exposure from gunshot on inner ear function.

    PubMed

    Wu, Chun-Ching; Young, Yi-Ho

    2009-01-01

    This longitudinal study investigated how chronic gunshot noise exposure affects cochlear and saccular function in police officers who engaged in regular target shooting practice using dual protection (ear plugs plus earmuffs) for >10 years. In 1997, 20 male police officers underwent audiometry before and two weeks after shooting. Twelve of the original subjects were re-examined by audiometry coupled with vestibular evoked myogenic potential (VEMP) test in 2007. Significant deterioration of mean hearing thresholds at frequencies of 500 Hz through 4000 Hz was noted ten years later, affecting both ears. However, only the frequencies of 4000 and 6000 Hz on the left ear revealed significant difference in mean hearing thresholds compared with healthy controls. Abnormal VEMP responses were evident in nine police officers (75%), including absent VEMPs 7 and delayed VEMPs 2. In conclusion, deterioration to hearing may occur after long term exposure to gunshots, even when double hearing protection is used. Further study is in progress regarding how to preserve both cochlear and saccular function during long term gunshot exposure. PMID:19925337

  12. Ten years of seismicity in the euro-mediterranean region: panorama of the EMSC bulletin 1998-2007

    NASA Astrophysics Data System (ADS)

    Godey, S.; Bossu, R.; Mazet-Roux, G.

    2009-04-01

    The Euro-Mediterranean Seismological Center (EMSC) is in charge of collecting seismological parametric data recorded by the local networks of the Euro-Mediterranean region in order to improve data availability for the seismologists and to rapidly produce a comprehensive seismicity bulletin for the region. The aims are to reproduce the seismicity as imaged by the local agencies when events occur within their network and to improve event location in borders regions and off-shore. In this presentation, we show ten years of seismicity that occurred in the Euro-Mediterranean region. Event locations have been obtained in the Euro-Med Bulletin for the period January 1998 to December 2007 by merging parametric data collected from 77 seismological agencies. Thanks to the many contributions, the Euro-Med Bulletin displays a high coverage of the region with the collection of data recorded by 2,625 stations and only two known missing networks. In total, more than 100,000 events are included for the period 1998-2007. We present here the performances of the Euro-Med Bulletin and their evolution over the years. In the spring 2009, the EMSC will produce a specific map of the Euro-Med seismicity. This map, dedicated to a wide audience will require a careful review and didactic selection of data. A special effort is needed to further discard non tectonic events from the current Euro-Med bulletin. This can be achieved by setting up additional collection of event type information (from rockburst to mine activity) with the help of the local networks. Additionally, the currently available bulletin may be recomputed using the global velocity model AK135.

  13. Trends, seasonal variability and dominant NOx source derived from a ten year record of NO2 measured from space

    NASA Astrophysics Data System (ADS)

    van der A, R. J.; Eskes, H. J.; Boersma, K. F.; van Noije, T. P. C.; van Roozendael, M.; de Smedt, I.; Peters, D. H. M. U.; Meijer, E. W.

    2008-02-01

    For the period 1996-2006, global distributions of tropospheric nitrogen dioxide (NO2) have been derived from radiances measured with the satellite instruments GOME (Global Ozone Monitoring Experiment) and SCIAMACHY (SCanning Imaging Absorption spectroMeter for Atmospheric CartograpHY). A statistical analysis is applied to derive trends and seasonal variability for this period on a global scale. The time series of the monthly NO2 columns for these ten years have been fitted with a linear function superposed on an annual seasonal cycle on a grid with a spatial resolution of 1° by 1°. We see significant reductions (up to 7% per year) in NO2 in Europe and parts of the eastern United States, and a strong increase in Asia, most particularly in China (up to 29% per year) but also in Iran and Russia. By comparing the data with the cloud information derived from the same satellite observations, the contribution of lightning to the total column of NO2 is estimated. The estimated NO2 from lightning is, especially in the tropics, in good agreement with lightning flash rate observations from space. The satellite observed seasonal variability of NO2 generally correlates well with independent observations and estimates of the seasonal cycle of specific NOx sources. Source categories considered are anthropogenic (fossil fuel and biofuel), biomass burning, soil emissions and lightning. Using the characteristics of the seasonal variability of these source categories, the dominant source of NOx emissions has been identified on a global scale and on a 1° by 1° grid.

  14. Ten-year growth response of young Douglas-fir to variable density varnishleaf ceanothus and herb competition

    USGS Publications Warehouse

    Monleon, V.J.; Newton, M.; Hooper, C.; Tappeiner, J. C., II

    1999-01-01

    The effect of different densities of varnishleaf ceanothus (Ceanothus velutinus var. laevigatus) and herbaceous vegetation control on stem diameter, height, and volume of plantation Douglas-fir (Pseudotsuga menziesii var. menziesii) seedlings was examined during the 10 yr following planting. Initial densities of ceanothus ranged between 0 and 15,000 seedlings/ha and were obtained by interplanting ceanothus germinants or chemical thinning after clearcutting and broadcast-burning. Herbaceous vegetation control was achieved by a single application of glyphosate following planting, with shrub seedlings covered. Ceanothus density in the range of 0 to 6,750 plants/ha did not have an effect on Douglas-fir diameter, height, or volume at age 10; however, Douglas-fir growth was significantly decreased when ceanothus densities reached 15,000 plants/ha. Ten years after planting, Douglas-fir volume in the treatments with 6,750 ceanothus/ha or less was 1.7 times greater than that in the 15,000 ceanothus/ha treatment. On the other hand, removal of herbaceous vegetation after planting significantly increased tree diameter, height, and volume, regardless of ceanothus density. Even 10 yr after the application of the treatment, trees without early herb competition grew faster and had mean dbh, height, and volume that were 1.02 cm, 0.55 m, and 12.98 dm3/tree greater respectively than those with herbs. Thus, a treatment at plantation establishment to control herbaceous vegetation and to reduce ceanothus density to less than 7,000 plants/ha will ensure an increase in growth and stocking for at least 10 yr.

  15. Ten Years' Research on a Cardiovascular Tonic: A Comprehensive Approach—From Quality Control and Mechanisms of Action to Clinical Trial

    PubMed Central

    Leung, Ping-Chung; Koon, Chi-Man; Lau, Clara Bik-San; Chook, Ping; Cheng, William King-Fai; Fung, Kwok-Pui; Kwok, Timothy Chi-Yui; Woo, Kam-Sang

    2013-01-01

    Objective. Mortality arising from cardiovascular pathologies remains one of the highest. Maintenance of cardiovascular health therefore remains a universal concern. Interventional therapies and medications have made impressive advances, but preventive measures would be of the same importance. Method. Ten years' search for a simple herbal formula has resulted in a two-herb combination, consisting of Salviae Miltiorrhizae Radix et Rhizoma and Puerariae Lobatae Radix. The formula has been studied extensively on cardiovascular biological platforms and then put on three clinical trials. Results. In the laboratory, the formula was found to have the biological effects of anti-inflammation, anti-oxidation, anti-foam cell formation on vascular endothelium, and vasodilation. Clinical trials using ultrasonic carotid intima thickness as a surrogate marker showed very significant benefits. No significant adverse effects were encountered. Conclusion. It is therefore recommended that the herbal formula could be used as an adjuvant therapy in cardiac patients under treatment or as a preventive agent among the susceptible. PMID:24324512

  16. The 'fine structure' of nutrient dynamics in rivers: ten years of study using high-frequency monitoring

    NASA Astrophysics Data System (ADS)

    Jordan, Phil; Melland, Alice; Shore, Mairead; Mellander, Per-Erik; Shortle, Ger; Ryan, David; Crockford, Lucy; Macintosh, Katrina; Campbell, Julie; Arnscheidt, Joerg; Cassidy, Rachel

    2014-05-01

    A complete appraisal of material fluxes in flowing waters is really only possibly with high time resolution data synchronous with measurements of discharge. Defined by Kirchner et al. (2004; Hydrological Processes, 18/7) as the high-frequency wave of the future and with regard to disentangling signal noise from process pattern, this challenge has been met in terms of nutrient flux monitoring by automated bankside analysis. In Ireland over a ten-year period, time-series nutrient data collected on a sub-hourly basis in rivers have been used to distinguish fluxes from different catchment sources and pathways and to provide more certain temporal pictures of flux for the comparative definition of catchment nutrient dynamics. In catchments where nutrient fluxes are particularly high and exhibit a mix of extreme diffuse and point source influences, high time resolution data analysis indicates that there are no satisfactory statistical proxies for seasonal or annual flux predictions that use coarse datasets. Or at least exposes the limits of statistical approaches to catchment scale and hydrological response. This has profound implications for catchment monitoring programmes that rely on modelled relationships. However, using high resolution monitoring for long term assessments of catchment mitigation measures comes with further challenges. Sustaining continuous wet chemistry analysis at river stations is resource intensive in terms of capital, maintenance and quality assurance. Furthermore, big data capture requires investment in data management systems and analysis. These two institutional challenges are magnified when considering the extended time period required to identify the influences of land-based nutrient control measures on water based systems. Separating the 'climate signal' from the 'source signal' in river nutrient flux data is a major analysis challenge; more so when tackled with anything but higher resolution data. Nevertheless, there is scope to lower

  17. What do you want to be in ten years? - Advising meteorology students in the post-Twister era

    NASA Astrophysics Data System (ADS)

    Snow, J. T.; Hempe, M.

    2012-12-01

    "What do you want to be in ten years?' This is a question we ask our students, freshmen and transfer, when they first arrive in the College student services center. Often the answer is "I don't know. I just want to be in meteorology." This response leads to a discussion of career opportunities in meteorology and related fields, including what might be called faux-careers, such as professional storm chasing and weather tour operations. (Students often have been misled by what they have seen in television shows.) Many students arrive on our doorstep with their heart set on a degree in meteorology, but lack knowledge of what the field is about or how challenging a meteorology degree program really is. We find ourselves spending a great deal of time convincing students that they need to explore the real opportunities in meteorology and related fields, which are many. Fortunately, because of the concentration of University and federal weather organizations in the National Weather Center and private sector weather companies in adjacent buildings, we are able to show concrete examples of real careers by means of tours, job shadowing, and introductions to alumni employed in these organizations. Also, as the students' progress in their studies, they discover the many opportunities for undergraduate employment, research experiences, and internships in these same organizations, through which they gain an appreciation for what constitutes a real career in modern meteorology. Further, many of today's careers in meteorology require a broad, global perspective. Unfortunately, many meteorology students have not traveled widely, but again have only seen what the media provides about distant lands and peoples. Accordingly, we encourage our undergraduate students to take advantage of our unique opportunities for overseas experiences in meteorology. Through arrangements with the met programs at the University of Reading (England), Monash University (Australia), and University of

  18. A new SO2 emissions budget for Anatahan volcano (Mariana Islands) based on ten years of satellite observations

    NASA Astrophysics Data System (ADS)

    McCormick, Brendan; Popp, Christoph; Andrews, Benjamin; Cottrell, Elizabeth

    2015-04-01

    Satellite remote sensing offers great potential for the study of sulphur dioxide (SO2) gas emissions from volcanoes worldwide. Anatahan is a remote volcano in the Mariana Islands, SW Pacific. Existing SO2 emissions data from Anatahan, from ground-based UV spectrometer measurements, place the volcano among the largest natural SO2 sources worldwide. However, these measurements are limited in number and only available from intervals of eruptive activity. Activity varies widely at Anatahan: over the past decade, records held in the Smithsonian Institution Global Volcanism Program Volcanoes of the World database describe the alternation of intense eruptions with long intervals of quiescence, where much lower intensity activity took place. We present ten years of satellite-based measurements of SO2 in the atmosphere over Anatahan, using data from the UV spectrometers OMI, GOME-2, and SCIAMACHY, and the IR spectrometer AIRS. We find Anatahan's emissions to be highly variable both within and between intervals of eruption and quiescence. We demonstrate a close agreement between trends in SO2 emission evident from our remote sensing data and records of activity compiled from a range of other sources and instruments, across daily to annual temporal scales. Mean eruptive SO2 emissions at Anatahan are ~6400 t/d, and range from <1000 to >18000 t/d. Quiescent emissions are below our instrument detection limits and are therefore unlikely to exceed 150-300 t/d. Overall, accounting for both eruptive and quiescent emissions, we calculate a revised decadal mean SO2 emission rate of 1060-1200 t/d. We further calculate a total decadal SO2 yield from Anatahan of 4-5 Mt, significantly lower than the 17-34 Mt calculated if ground-based campaign data are used in isolation. The use of isolated measurements to extrapolate longer term emissions budgets is subject to clear uncertainty, and we argue that our satellite observations, covering a longer interval of Anatahan's history, are better

  19. Let Book Joy Begin @ Your Library[R]!: Ten Years of El Dia de los Ninos/El Dia de los Libros

    ERIC Educational Resources Information Center

    Roy, Loriene

    2007-01-01

    Ten years ago, in 1996, poet and children's book author, Pat Mora began celebrating "book joy" by founding a children's book and reading day, El Dia de los Ninos/El Dia de los Libros or Children's Day/Book Day. Dia is modeled on National Children's Day Celebrations in Mexico held since 1925 when it was launched in conjunction with a World…

  20. OYSTER POPULATUION ESTIMATION IN SUPPORT OF THE TEN-YEAR GOAL FOR OYSTER RESOTRATION IN THE CHESAPEAKE BAY: DEVELOPING STRATEGIES FOR RESTORING AND MANAGING THE EASTERN OYSTER

    EPA Science Inventory

    Mann, Roger, Steve Jordan, Gary Smith, Kennedy Paynter, James Wesson, Mary Christman, Jessica Vanisko, Juliana Harding, Kelly Greenhawk and Melissa Southworth. 2003. Oyster Population Estimation in Support of the Ten-Year Goal for Oyster Restoration in the Chesapeake Bay: Develop...

  1. Ten-Year Mortality after a Breast Cancer Diagnosis in Women with Severe Mental Illness: A Danish Population-Based Cohort Study

    PubMed Central

    Ribe, Anette Riisgaard; Laurberg, Tinne; Laursen, Thomas Munk; Charles, Morten; Vedsted, Peter; Vestergaard, Mogens

    2016-01-01

    Background Breast cancer is the leading cause of cancer death in women worldwide. Nevertheless, it is unknown whether higher mortality after breast cancer contributes to the life-expectancy gap of 15 years in women with severe mental illness (SMI). Methods We estimated all-cause mortality rate ratios (MRRs) of women with SMI, women with breast cancer and women with both disorders compared to women with neither disorder using data from nationwide registers in Denmark for 1980–2012. Results The cohort included 2.7 million women, hereof 31,421 women with SMI (12,852 deaths), 104,342 with breast cancer (52,732 deaths), and 1,106 with SMI and breast cancer (656 deaths). Compared to women with neither disorder, the mortality was 118% higher for women with SMI (MRR: 2.18, 95% confidence interval (CI): 2.14–2.22), 144% higher for women with breast cancer (MRR: 2.44, 95% CI: 2.42–2.47) and 327% higher for women with SMI and breast cancer (MRR: 4.27, 95% CI: 3.98–4.57). Among women with both disorders, 15% of deaths could be attributed to interaction. In a sub-cohort of women with breast cancer, the ten-year all-cause-mortality was 59% higher after taking tumor stage into account (MRR: 1.59, 95% CI: 1.47–1.72) for women with versus without SMI. Conclusions The mortality among women with SMI and breast cancer was markedly increased. More information is needed to determine which factors might explain this excess mortality, such as differences between women with and without SMI in access to diagnostics, provision of care for breast cancer or physical comorbidity, health-seeking-behavior, and adherence to treatment. PMID:27462907

  2. BIFoR FACE: A ten-year Free-Air Carbon Dioxide Enrichment (FACE) Experiment in Old Growth Deciduous English Woodland

    NASA Astrophysics Data System (ADS)

    Thomas, R. M.; MacKenzie, A. R.; Ellsworth, D.; Hemming, D.; Crous, K.; Pope, F.; Blaen, P.; Poynter, A.; Hamilton, L.; Blenkhorn, D.; Jarvis-Rouse, F.

    2015-12-01

    The Birmingham Institute of Forest research (BIFoR) will perform fundamental physical, biological, ecological, social and cultural research of direct relevance to forested landscapes worldwide. A core platform for BIFoR to study the ten-year response of a mature temperate deciduous forest ecosystem to against a large step-change in atmospheric [CO2] is the BIFoR Free-Air Carbon Dioxide Enrichment (FACE) experiment. BIFoR FACE is being established in Mill Haft, a mature (~150 year-old) oak (Quercus robur) and hazel (Corylus avellana) coppice-with-standards woodland in central England. The facility will enable elevated CO2 (eCO2) treatments to be introduced in 30 m diameter rings (3 treatment and 6 control plots), commencing in spring 2016. Under eCO2 conditions primary research questions will investigate carbon uptake and storage, corresponding nutrient limitations, and biodiversity and ecosystem responses. As well as describing the facility and experimental design, we present baseline data collected throughout 2015, prior to fumigation. These data include: biophysical tree properties; atmospheric CO2/H2O fluxes; airborne and ground laser scatterometry; leaf area index; geophysical survey data; phenology camera derivatives; soil and water chemical and physical properties; and invertebrate surveys. Data from an intensive campaign conducted during august 2015 are also shown, including in- and above- canopy characterisation of biogenic VOCs using a Proton Transfer Reaction Mass Spectrometer, aerosol loading including bioaerosols, and enhanced atmospheric chemistry. Further campaign results are presented from leaf level photosynthetic carbon-dioxide response curve (A/Ci) performed at different canopy heights on oak trees, and on the dominant understory species - hazel and sycamore (Acer pseudoplatinus) across the site. BIFoR FACE is an exciting new international facility for forest science - ideas for collaborations are encouraged. Please see http

  3. Ten years of CO2, CH4, CO and N2O fluxes over Western Europe inferred from atmospheric measurements at Mace Head, Ireland

    NASA Astrophysics Data System (ADS)

    Messager, C.; Schmidt, M.; Ramonet, M.; Bousquet, P.; Simmonds, P.; Manning, A.; Kazan, V.; Spain, G.; Jennings, S. G.; Ciais, P.

    2008-01-01

    We estimated CO2, CH4, CO and N2O emission fluxes over the British Isles and Western Europe using atmospheric radon observations and concentrations recorded at the Mace Head Atmospheric Research Station between 1996 and 2005. We classified hourly concentration data into either long-range European or regional sources from Ireland and UK, by using local wind speed data in conjunction with 222Rn and 212Pb threshold criteria. This leads to the selection of about 7% of the total data for both sectors. We then used continuous 222Rn measurements and assumptions on the surface emissions of 222Rn to deduce the unknown fluxes of CO2, CH4, CO and N2O. Our results have been compared to the UNFCCC, EMEP and EDGAR statistical inventories and to inversion results for CH4. For Western Europe, we found yearly mean fluxes of 4.1±1.5 106 kg CO2 km-2 yr-1 , 11.9±2.0 103 kg CH4 km-2 yr-1, 12.8±4.2 103 kg CO km-2 yr-1 and 520.2±129.2 kg N2O km-2 yr-1, respectively, for CO2, CH4, CO and N2O over the period 1996-2005. The method based upon 222Rn to infer emissions has many sources of systematic errors, in particular its poorly known and variable footprint, uncertainties in 222Rn soil fluxes and in atmospheric mixing of air masses with background air. However, these biases are likely to remain constant in the long-term, which makes the method quite efficient to detect trends in fluxes. Over the last ten years period, the decrease of the anthropogenic CH4, CO and N2O emissions in Europe estimated by inventories (respectively -30%, -35% and -23%) is confirmed by the Mace Head data within 2%. Therefore, the 222Rn method provides an independent way of verification of changes in national emissions derived from inventories. Using European-wide estimates of the CO/CO2 emission ratio, we also found that it is possible to separate the fossil fuel CO2 emissions contribution from the one of total CO2 fluxes. The fossil fuel CO2 emissions and their trends derived in that manner agree very well

  4. A ten year summary of concurrent ambient water column and sediment toxicity tests in the Chesapeake Bay watershed: 1990-1999.

    PubMed

    Hall, Lenwood W; Anderson, Ronald D; Alden, Raymond W

    2002-06-01

    The goal of this study was to identify the relative toxicity of ambient areas in the Chesapeake Bay watershed by using a suite of concurrent water column and sediment toxicity tests at seventy-five ambient stations in 20 Chesapeake Bay rivers from 1990 through 1999. Spatial and temporal variability was examined at selected locations throughout the 10 yr study. Inorganic and organic contaminants were evaluated in ambient water and sediment concurrently with water column and sediment tests to assess possible causes of toxicity although absolute causality can not be established. Multivariate statistical analysis was used to develop a multiple endpoint toxicity index (TOX-INDEX) at each station for both water column and sediment toxicity data. Water column tests from the 10 yr testing period showed that 49% of the time, some degree of toxicity was reported. The most toxic sites based on water column results were located in urbanized areas such as the Anacostia River, Elizabeth River and the Middle River. Water quality criteria for copper, lead, mercury, nickel and zinc were exceeded at one or more of these sites. Water column toxicity was also reported in localized areas of the South and Chester Rivers. Both spatial and temporal variability was reported from the suite of water column toxicity tests. Some degree of sediment toxicity was reported from 62% of the tests conducted during the ten year period. The Elizabeth River and Baltimore Harbor stations were reported as the most toxic areas based on sediment results. Sediment toxicity guidelines were exceeded for one or more of the following metals at these two locations: arsenic, cadmium, chromium, copper, lead, nickel and zinc. At the Elizabeth River stations nine of sixteen semi-volatile organics and two of seven pesticides measured exceeded the ER-M values in 1990. Ambient sediment toxicity tests in the Elizabeth River in 1996 showed reduced toxicity. Various semi-volatile organics exceeded the ER-M values at a

  5. Frequency and antimicrobial resistance patterns of bacteria implicated in community urinary tract infections: a ten-year surveillance study (2000–2009)

    PubMed Central

    2013-01-01

    Background Urinary tract infection (UTI) is one of the most common infectious diseases at the community level. In order to assess the adequacy of the empirical therapy, the prevalence and the resistance pattern of the main bacteria responsible for UTI in the community (in Aveiro, Portugal) was evaluated throughout a ten-year period. Methods In this retrospective study, all urine samples from patients of the District of Aveiro, in ambulatory regime, collected at the Clinical Analysis Laboratory Avelab during the period 2000–2009 were analysed. Samples with more than 105 CFU/mL bacteria were considered positive and, for these samples, the bacteria were identified and the profile of antibiotic susceptibility was characterized. Results From the 155597 samples analysed, 18797 (12.1%) were positive for bacterial infection. UTI was more frequent in women (78.5%) and its incidence varied with age, affecting more the elderly patients (38.6%). Although E. coli was, as usual, the most common pathogen implicated in UTI, it were observed differences related to the other bacteria more implicated in UTI relatively to previous studies. The bacteria implicated in the UTI varied with the sex of the patient, being P. aeruginosa a more important cause of infection in men than in women. The incidence of the main bacteria changed over the study period (P. aeruginosa, Klebsiella spp and Providencia spp increased and Enterobacter spp decreased). Although E. coli was responsible for more than an half of UTI, its resistance to antibiotics was low when compared with other pathogens implicated in UTI, showing also the lowest percentage of multidrug resistant (MDR) isolates (17%). Bacteria isolated from females were less resistant than those isolated from males and this difference increased with the patient age. Conclusions The differences in sex and age must be taken into account at the moment of empirical prescription of antimicrobials. From the recommended antimicrobials by the European

  6. Best Practices in Career Development Programs for Post Secondary Students with Learning Disabilities: A Ten-Year Follow-up.

    ERIC Educational Resources Information Center

    Michaels, Craig A.; Barr, Vickie M.

    2002-01-01

    Examination of nine federally funded projects identified as national models in assisting the career development of college students with learning disabilities resulted in recommendations in key areas: agency collaboration, business/industry outreach, advisory boards, career assessment, career-technical education, internships, cooperative…

  7. Reported Numbers of Patients with Rare Diseases Based on Ten-Year Longitudinal National Disability Registries in Taiwan

    ERIC Educational Resources Information Center

    Lin, Jin-Ding; Lin, Lan-Ping; Hung, Wen-Jiu

    2013-01-01

    This paper aims to describe a general demographic picture of patients with rare diseases in Taiwan and particularly focuses on the prevalence of rare diseases over time, age and gender distributions. We analyzed data mainly from the national disability registry from 2002 to 2011 in Taiwan, Republic of China. The results showed that the number of…

  8. Reliability of Selected Measures of Movement Control and Force Production on Children Four Through Ten Years of Age.

    ERIC Educational Resources Information Center

    Heston, Melissa; And Others

    1986-01-01

    The purpose of this study was to establish tentative reliability estimates for movement control and force production tasks as the initial phase of a cross-cultural motor-performance study. Ten boys and ten girls for each of seven age groups (ages four through ten) performed four specific tasks. Results are discussed. (MT)

  9. Ten-Year Safety with Polyacrylamide Gel Used to Correct Facial Lipoatrophy in HIV-Infected Patients.

    PubMed

    Negredo, Eugenia; Puig, Jordi; Ornelas, Arelly; Echeverría, Patricia; Bonjoch, Anna; Estany, Carla; Higueras, Carmen; Gonzalez-Mestre, Vicente; Clotet, Bonaventura

    2015-08-01

    Long-term results (>5 years) for synthetic substances used to repair facial lipoatrophy have not been published. We performed a cross-sectional study to evaluate the 10-year safety of polyacrylamide hydrogel (Aquamid) among the 751 patients from our unit who received facial infiltrations at least 10 years ago. Epidemiological and clinical data such as complications and patient satisfaction were collected. We also identified those patients who presented a facial infection at any time after infiltration. A total of 104 patients had received Aquamid at least 10 years ago. Before infiltrations, 24.0%, 41.3%, and 34.7% presented very severe, severe, and moderate facial lipoatrophy, respectively. After a mean (SD) of 10.3 (0.5) years since the infiltrations, 19.2%, 47.7%, and 31.7% of patients reported moderate, mild, and no signs of facial lipoatrophy. The values reported by physicians for the same categories were 1.9%, 10.6%, and 87.5%. Indurations were detected in 6.7% of patients and nodules in 3.8%. Five patients (4.8%) had a local infection. A further 15 patients with a shorter follow-up (less than 10 years) presented local infections (overall incidence considering the 751 patients who received infiltrations of Aquamid, 2.7%); the product had to be withdrawn in three cases. The majority of patients were highly satisfied (74.8%) or satisfied (23.4%) with the cosmetic results; among patients with severe or very severe lipoatrophy at baseline, 31.4% were satisfied and 65.7% were highly satisfied. Infiltrations with polyacrylamide hydrogel (Aquamid) are a safe strategy for the treatment of facial lipoatrophy in the long term. The rate of severe complications was low, and patient satisfaction with the cosmetic results was high. However, facial infections may appear in the long term. Therefore, HIV-infected patients who received synthetic substances should be carefully monitored over time. PMID:25858612

  10. Ten Years of Chronic Cough in a 64-Year-Old Man With Multiple Pulmonary Nodules.

    PubMed

    Warren, Whittney A; Dalane, Scott S; Warren, Bryce D; Peterson, Paul G; Boyum, Rodney D; Kelly, William

    2016-09-01

    A 64-year-old male former smoker with a history of prostate cancer presented to our pulmonary clinic, complaining of nonproductive cough for 10 years. Prior evaluation included treatment for upper airway cough syndrome and gastroesophageal reflux, stopping angiotensin-converting enzyme inhibitor, and initiation of inhaled β-agonists. Esophageal pH monitoring indicated silent reflux, and proton pump inhibitor therapy was started. He continued to cough and complain of dyspnea. Physical examination produced unremarkable results, with no evidence of lymphadenopathy. Pulmonary function tests showed a pseudo-restrictive pattern with air trapping, hyperreactivity, and incomplete bronchodilator responsiveness: FEV1, 2.48 L (69% of predicted); FVC, 3.57 L (75% of predicted); FEV1/FVC, 92%; total lung capacity, 7.00 L (100% of predicted); and residual volume, 3.05 L (136% of predicted). Laboratory studies, including a complete metabolic panel, prostate-specific antigen test, and complete blood count, yielded normal results. PMID:27613994

  11. A ten-year review of lower extremity burns in diabetics: small burns that lead to major problems.

    PubMed

    Barsun, Alura; Sen, Soman; Palmieri, Tina L; Greenhalgh, David G

    2013-01-01

    Diabetes mellitus with its resulting neurovascular changes may lead to an increased risk of burns and impaired wound healing. The purpose of this article is to review 10 years of experience with foot and lower leg burns in patients with diabetes at a single adult burn center. Patients with lower extremity burns and diabetes mellitus, between May 1999 and December 2009, were identified in the Trauma Registry of the American College of Surgeons database, and their charts were reviewed for data related to their outcomes. Sixty-eight diabetic patients, 87% male, with a mean age of 54 years, sustained foot or lower extremity burns with 37 having burns resulting from insensate feet. The pathogenesis included walking on a hot or very cold surface (8), soaking feet in hot water (22), warming feet on or near something hot such as a heater (13), or spilling hot water (7). The majority of patients were taking insulin (59.6%) or oral hyperglycemic medications (34.6%). Blood sugar levels were not well controlled (mean glucose, 215.8 mg/dl; mean hemoglobin A1c, 9.08%). Renal disease was common with admission serum blood urea nitrogen (27.5 mg/dl) and creatinine (2.21 mg/dl), and 13 were on dialysis preinjury. Cardiovascular problems were common with 39 (57%) having hypertension or cardiac disease, 3 having peripheral vascular disease, and 9, previous amputations. The mean burn size was 4.2% TBSA (range, 0.5-15%) with 57% being full thickness. Despite the small burn, the mean length of stay was 15.2 days (range, 1-95), with 5.65 days per 1% TBSA. Inability to heal these wounds was evident in 19 patients requiring readmission (one required 10 operative procedures). At least one patient sustained more than one burn. There were 62 complications with 30 episodes of infection (cellulitis, 28; osteomyelitis, 4; deep plantar infections, 2; ruptured Achilles tendon, 1) and 3 deaths. Eleven patients needed amputations (7 below-knee amputations, 4 transmetatarsal amputations, and 20 toe

  12. Ten-Year Follow-Up Study of PTSD Diagnosis, Symptom Severity, and Psychosocial Indices in Aging Holocaust Survivors

    PubMed Central

    Schmeidler, James; Labinsky, Ellen; Bell, Amanda; Morris, Adam; Zemelman, Shelly; Grossman, Robert A.

    2009-01-01

    Objective We performed a longitudinal study of Holocaust survivors with and without PTSD by assessing symptoms and other measures at two intervals, approximately 10 years apart. Method The original cohort consisted of 63 community-dwelling subjects, of whom 40 were available for follow-up. Results There was a general diminution in PTSD symptom severity over time. However, in 10% of the subjects (n=4), new instances of Delayed Onset PTSD developed between the Time 1 and Time 2. Self-report ratings at both assessments revealed a worsening of trauma related symptoms over time in persons without PTSD at Time 1, but an improvement in those with PTSD at Time 1. Conclusion The findings suggest that a nuanced characterization of PTSD trajectory over time is more reflective of PTSD symptomatology than simple diagnostic status at one time. The possibility of Delayed Onset trajectory complicates any simplistic overall trajectory summarizing the longitudinal course of PTSD. PMID:18785948

  13. Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study.

    PubMed

    Revier, Camice J; Reininghaus, Ulrich; Dutta, Rina; Fearon, Paul; Murray, Robin M; Doody, Gillian A; Croudace, Tim; Dazzan, Paola; Heslin, Margaret; Onyejiaka, Adanna; Kravariti, Eugenia; Lappin, Julia; Lomas, Ben; Kirkbride, James B; Donoghue, Kim; Morgan, Craig; Jones, Peter B

    2015-05-01

    It has long been held that schizophrenia and other psychotic disorders have a predominately poor course and outcome. We have synthesized information on mortality, clinical and social outcomes from the ÆSOP-10 multicenter study, a 10-year follow-up of a large epidemiologically characterized cohort of 557 people with first-episode psychosis. Symptomatic remission and recovery were more common than previously believed. Distinguishing between symptom and social recovery is important given the disparity between these; even when symptomatic recovery occurs social inclusion may remain elusive. Multiple factors were associated with an increased risk of mortality, but unnatural death was reduced by 90% when there was full family involvement at first contact compared with those without family involvement. These results suggest that researchers, clinicians and those affected by psychosis should countenance a much more optimistic view of symptomatic outcome than was assumed when these conditions were first described. PMID:25900547

  14. Use of low-level laser therapy (LLLT) in the treatment of some pulmonary diseases: ten-year experience

    NASA Astrophysics Data System (ADS)

    Derbenev, V. A.; Mikhailov, V. A.; Denisov, I. N.

    2000-06-01

    The purpose of this study was to compare the efficacy of the treatment of some pulmonary diseases with our without LLLT. 130 patients received LLLT and drug therapy, and 30 patients received only drug therapy. The obtained results on the use of LLLT show that the period of convalescence in patients with both pneumonia and exacerbation of chronic bronchitis was lower with 4-6 days compared with control group. 68 percent patients with chronic bronchitis have staunch remission more than three months. Patients with bronchial asthma reported the decreasing of both number of bronchospasms and doses of bronchodilators and glucocorticoids after LLLT. They have no exacerbation of asthma during 3-6 months; then these patients need the repetition of LLLT. In conclusion, LLLT is the suitable and effective complement to the treatment of pulmonary diseases.

  15. Washington's energy mess: after ten years of Federal meddling in the oil business, we're over a barrel

    SciTech Connect

    Sawyer, J.

    1980-09-01

    New regulations in response to a 1970 call for decontrolling the petroleum industry encouraged foreign production and imports while discouraging domestic exploration. The oil industry was strong enough to profit from government programs, but not enough to prevent pervasive interference in its operations and investments. The result has been supply disruptions and more dependence on foreign oil. The price control system operating during the 1970s had no provision for inflation and was biased toward refineries having access to domestic crude oil. This led to an entitlements program that modified competition further. A review of these and other programs, such as the mandatory crude-oil buy/sell program, shows how they altered the relationships between suppliers and buyers. The 1980 Windfall Profit Tax continues a decade of favoring foreign production, reflecting public aversion to true decontrol, and a public addiction to Federal intervention. (DCK)

  16. Ten-year ground exposure of composite materials used on the Bell Model 206L helicopter flight service program

    NASA Technical Reports Server (NTRS)

    Baker, Donald J.

    1994-01-01

    Residual strength results are presented for four composite material systems that have been exposed for up to 10 years to the environment at five different locations on the North American continent. The exposure locations are near where the Bell Model 206L helicopters, which participated in a flight service program sponsored by NASA Langley Research Center and the U.S. Army, were flying in daily commercial service. The composite material systems are (1) Kevlar-49 fabric/F-185 epoxy; (2) Kevlar-49 fabric/LRF-277 epoxy; (3) Kevlar-49 fabric/CE-306 epoxy; and (4) T-300 graphite/E-788 epoxy. Six replicates of each material were removed and tested after 1, 3, 5, 7, and 10 years of exposure. The average baseline strength was determined from testing six as-fabricated specimens. More than 1700 specimens have been tested. All specimens that were tested to determine their strength were painted with a polyurethane paint. Each set of specimens also included an unpainted panel for observing the weathering effects on the composite materials. A statistically based procedure has been used to determine the strength value above which at least 90 percent of the population is expected to fall with a 95-percent confidence level. The computed compression strengths are 80 to 90 percent of the baseline (no-exposure) strengths. The resulting compression strengths are approximately 8 percent below the population mean strengths. The computed short-beam-shear strengths are 83 to 92 percent of the baseline (no-exposure) strengths. The computed tension strength of all materials is 93 to 97 percent of the baseline (no-exposure) strengths.

  17. Ten-year survival analysis for renal carcinoma patients treated with an autologous tumour lysate vaccine in an adjuvant setting.

    PubMed

    May, Matthias; Brookman-May, Sabine; Hoschke, Bernd; Gilfrich, Christian; Kendel, Friederike; Baxmann, Susann; Wittke, Stefan; Kiessig, Stephan T; Miller, Kurt; Johannsen, Manfred

    2010-05-01

    About 30% of renal cell carcinomas (RCC) will develop recurrence after surgery. Despite evidence for a significantly improved survival by autologous tumour cell vaccination therapy, the procedure has not become standard. Between August 1993 and December 1996, 1,267 RCC patients undergoing radical nephrectomy in 84 German hospitals were subsequently treated by autologous tumour cell vaccination therapy. The study group comprised 692 patients with complete follow-up (stages pT2-3, pNx-2, M0 based on the TNM classification, 4th edition). Subsequent propensity-score matching according to 7 defined criteria with 861 control patients undergoing nephrectomy alone without adjuvant treatment at the Carl-Thiem-Hospital Cottbus, resulted in 495 matched pairs. Overall and stage-specific survival rates were analysed after a median follow-up of 131 months. The 5- and 10-year overall survival (OS) rates were 80.6 and 68.9% in the vaccine group and 79.2 and 62.1% in the control group (p = 0.066). Patients with pT3 stage RCC revealed 5- and 10-year OS rates of 71.3 and 53.6% in the study group and 65.4 and 36.2% in the control group (p = 0.022). In multivariable analysis, patients in the vaccine group showed a significantly improved survival both in the whole study group (HR = 1.28, p = 0.030) and in the subgroup presenting with pT3 stage tumours (HR = 1.67, p = 0.011). Adjuvant treatment with autologous vaccination therapy resulted in a significantly improved overall survival in pT3 stage RCC patients, suggesting benefit especially in this subgroup. However, controlled clinical trials integrating the recent TNM classification and further risk constellations are required to define additional patient groups that may derive benefit from this treatment. PMID:19876628

  18. Ten-year survival of hepatocellular carcinoma patients undergoing radiofrequency ablation as a first-line treatment

    PubMed Central

    Yang, Wei; Yan, Kun; Goldberg, S Nahum; Ahmed, Muneeb; Lee, Jung-Chieh; Wu, Wei; Zhang, Zhong-Yi; Wang, Song; Chen, Min-Hua

    2016-01-01

    AIM: To investigate the long-term survival and prognostic factors in hepatocellular carcinoma (HCC) patients undergoing radiofrequency ablation (RFA) as a first-line treatment. METHODS: From 2000 to 2013, 316 consecutive patients with 404 HCC (1.0-5.0 cm; mean: 3.2 ± 1.1 cm) underwent ultrasonography-guided percutaneous RFA as a first-line treatment. There were 250 males and 66 females with an average age of 60.1 ± 10.8 years (24-87 years). Patients were followed for 1 year to > 10 years after RFA (234, 181, 136, and 71 for 3, 5, 7, and 10 years, respectively). Overall local response rates and long-term survival rates were assessed. Survival results were generated using Kaplan-Meier estimates, and multivariate analysis was performed using the Cox regression model. RESULTS: In total, 548 RFA sessions were performed and major complications occurred in 10 sessions (1.8%). Local tumor progression and/or new tumor development were observed in 43.3% (132/305) of the patients during the follow-up period. Overall 5- and 10-year survival rates were 49.7% and 28.4%, respectively. Based on multivariate analysis, three factors were identified as independent prognostic factors for overall survival: Child-Pugh classification (HR = 4.054, P < 0.001), portal vein hypertension (HR = 2.743, P = 0.002), and tumor number (HR = 2.693, P = 0.003). The local progression-free 5- and 10-year survival rates were 42.7% and 19.5%. In addition to the Child-Pugh classification and the number of tumors, the number of RFA sessions (HR = 1.550, P = 0.002) was associated with local progression-free survival. CONCLUSION: RFA can achieve acceptable outcomes for HCC patients as a first-line treatment, especially for patients with Child-Pugh class A, patients with a single tumor and patients without portal vein hypertension. PMID:26973395

  19. [Evaluation of France's contributions to the Global Fund to Fight AIDS, Tuberculosis and Malaria: Ten years later].

    PubMed

    Kerouedan, D

    2014-01-01

    For 30 years, France has been very committed politically in the international combat against AIDS. The discovery of the AIDS virus at the Pasteur Institute in 1983, the AIDS summit meeting convened by Simone Veil in 1994, the excellence of research by French institutions on its virologic and other aspects as well as the socioeconomic and anthropological issues, and the strong commitment to international technical cooperation against this disease - all these have made (and continue to make) France a major political, technical, and financial participant in this battle against the combined pandemic of AIDS and tuberculosis. More than 10 years after the creation of the Global Fund, 5 years after the first evaluation of this Fund, and 2 years before the schedule for meeting the Millennium Development Goals, an assessment commissioned in 2013 from a French consulting firm of the French contributions is timely. The study was expected. Its results are disappointing. Why? Because the team chosen to conduct the assessment has a limited knowledge of the history of the interventions already funded by France and of the results of earlier assessments. The point was not to repeat the same observations but to move forward to see where they lead. In addition, the current and coming challenges are not considered. The countries to which France is providing cooperation are on the continent that after 30 years remains the most heavily affected by the pandemic. Several transitions are occurring there simultaneously: epidemiologic, demographic and urban. These metamorphoses influencing social values quite substantially, as well as risk factors for transmission of the AIDS virus; at the same time, they facilitate overcrowding and the propagation of tuberculosis. Nor do the authors consider the resistance of these infectious agents to the most commonly used drugs. The effects of the propagation of AIDS, of the expansion of armed conflicts in French-speaking Africa and of the sexual

  20. Socially-marketed rapid diagnostic tests and ACT in the private sector: ten years of experience in Cambodia.

    PubMed

    Yeung, Shunmay; Patouillard, Edith; Allen, Henrietta; Socheat, Duong

    2011-01-01

    Whilst some populations have recently experienced dramatic declines in malaria, the majority of those most at risk of Plasmodium falciparum malaria still lack access to effective treatment with artemisinin combination therapy (ACT) and others are already facing parasites resistant to artemisinins.In this context, there is a crucial need to improve both access to and targeting of ACT through greater availability of good quality ACT and parasitological diagnosis. This is an issue of increasing urgency notably in the private commercial sector, which, in many countries, plays an important role in the provision of malaria treatment. The Affordable Medicines Facility for malaria (AMFm) is a recent initiative that aims to increase the provision of affordable ACT in public, private and NGO sectors through a manufacturer-level subsidy. However, to date, there is little documented experience in the programmatic implementation of subsidized ACT in the private sector. Cambodia is in the unique position of having more than 10 years of experience not only in implementing subsidized ACT, but also rapid diagnostic tests (RDT) as part of a nationwide social marketing programme. The programme includes behaviour change communication and the training of private providers as well as the sale and distribution of Malarine, the recommended ACT, and Malacheck, the RDT. This paper describes and evaluates this experience by drawing on the results of household and provider surveys conducted since the start of the programme. The available evidence suggests that providers' and consumers' awareness of Malarine increased rapidly, but that of Malacheck much less so. In addition, improvements in ACT and RDT availability and uptake were relatively slow, particularly in more remote areas.The lack of standardization in the survey methods and the gaps in the data highlight the importance of establishing a clear system for monitoring and evaluation for similar initiatives. Despite these limitations, a

  1. Two to ten years: Developmental trajectories of joint attention in children with ASD who received targeted social communication interventions

    PubMed Central

    Gulsrud, Amanda C.; Hellemann, Gerhard S.; Freeman, Stephanny F.N.; Kasari, Connie

    2014-01-01

    Lay Abstract This study follows 40 children who were participants in a randomized controlled early intervention trial (Kasari et al., 2006, 2008, 2012) from early childhood (2–5 years of age) to elementary school age (8–10 years). The growth trajectories of social-communication and language outcomes in these children were estimated based on 5 time points during that period. The children were grouped by diagnosis at the last follow-up (Autism, ASD, No Diagnosis) and by their original treatment group assignment (Joint attention, Symbolic Play, Control), and differences between these groups evaluated. Results showed that joint attention skills of coordinated joint looking and showing increased over time and pointing to share interest increased over the first year measured and decreased thereafter. These trajectories were influenced by both original treatment assignment and diagnostic status at the follow-up. In addition, a cross-lagged panel analysis suggests a causal relationship between early pointing and later language development. This study highlights the longitudinal and developmental importance of measures of early core deficits in autism and suggests that both treatment and ASD symptomatology may influence growth in these skills over time. Scientific Abstract This study follows 40 children who were participants in a randomized controlled early intervention trial (Kasari et al., 2006, 2008, 2012) from early childhood (2–5 years of age) to elementary school age (8–10 years). To fully utilize the available longitudinal data, the general linear mixed model (GLMM) was the primary analytical approach. The growth trajectories of joint attention skills (pointing, coordinated joint looking and showing) and expressive language outcomes in these children were estimated based on 5 time points during the measurement period. The children were grouped by diagnosis at the last follow-up (Autism, ASD, No Diagnosis) and by their original treatment group assignment

  2. Personality Effects on Romantic Relationship Quality through Friendship Quality: A Ten-Year Longitudinal Study in Youths

    PubMed Central

    Yu, Rongqin; Branje, Susan; Keijsers, Loes; Meeus, Wim H. J.

    2014-01-01

    This study examined whether individuals with different personality types (i.e., overcontrollers, undercontrollers, resilients) had different friendship quality development throughout adolescence. It also investigated whether personality types were indirectly related to romantic relationship quality in young adulthood, via friendship quality development in adolescence. The study employed six waves of longitudinal questionnaire data from Dutch youths who had a romantic relationship when they were young adults. Two age cohorts were followed, from 12 to 21 years and from 16 to 25 years, respectively. Findings showed that resilients reported higher mean levels of friendship quality during adolescence (i.e., more support from, less negative interaction with and less dominance from their best friend) than both overcontrollers and undercontrollers. Through the mean levels of friendship quality throughout adolescence, resilients indirectly experienced higher romantic relationship quality during young adulthood than both overcontrollers and undercontrollers. Thus, results provide support for a developmental model in which adolescent friendship quality is a mechanism linking personality types with young adulthood romantic relationship quality. PMID:25232964

  3. Prediction of psychopathology and functional impairment by positive and negative schizotypy in the Chapmans' ten-year longitudinal study.

    PubMed

    Kwapil, Thomas R; Gross, Georgina M; Silvia, Paul J; Barrantes-Vidal, Neus

    2013-08-01

    The present study examined the predictive validity of psychometrically assessed positive and negative schizotypy in the Chapmans' 10-year longitudinal data set. Schizotypy provides a useful construct for understanding the etiology and development of schizophrenia and related disorders. Schizotypy and schizophrenia share a common multidimensional structure that includes positive and negative symptom dimensions. Recent cross-sectional studies have supported the validity of psychometric positive and negative schizotypy; however, the present study is the first to examine the predictive validity of these dimensions. The Chapmans' longitudinal data provided an ideal opportunity because of the large sample size, high reassessment rate, and extended interval between assessments. A total of 534 psychometric high-risk and control participants were initially assessed, and 95% of this sample was reinterviewed 10 years later. As hypothesized, positive and negative schizotypy uniquely predicted the development of schizophrenia-spectrum disorders. At the reassessment, both positive and negative schizotypy predicted psychotic-like, schizotypal, and paranoid symptoms, as well as poorer adjustment. The positive dimension was associated with mood and substance use disorders and mental health treatment. Negative schizotypy was associated with schizoid symptoms and social impairment at the follow-up. The results extend the growing validity findings for psychometrically assessed positive and negative schizotypy by demonstrating that they are associated with the development of differential patterns of symptoms and impairment. PMID:24016018

  4. Intracranial hemorrhage in acute and chronic childhood immune thrombocytopenic purpura over a ten-year period: an Egyptian multicenter study.

    PubMed

    Elalfy, Mohsen; Elbarbary, Nancy; Khaddah, Normine; Abdelwahab, Magy; El Rashidy, Farida; Hassab, Hoda; Al-Tonbary, Youssef

    2010-01-01

    Intracranial hemorrhage (ICH) is a rare but major cause of death in immune thrombocytopenic purpura (ITP). The authors reviewed data of 1,840 patient with ITP, from 5 pediatric hematology centers in Egypt from 1997 to 2007, to study the incidence and risk factors of ICH. Ten cases of ICH were identified with a median age at presentation of 7.5 years; 4 patients had acute ITP, 2 persistent and 4 chronic. The platelet count was <10 x 10(9)/l in 7 cases, and only 1 patient had a history of head trauma. Seven children were on treatment prior to or at the time of occurrence of ICH and all were treated by pharmacotherapy. Two children died shortly afterwards due to late referral to a specialized center. Our results suggest that treatment does not prevent ICH and that it can occur at any time during the course of the disease. Delayed referral can be considered a risk factor for unfavorable outcome of ICH, highlighting the importance of teaching sessions for patients and their parents to minimize subsequent morbidity and mortality of ICH in children with ITP. PMID:19955713

  5. Two to ten years: developmental trajectories of joint attention in children with ASD who received targeted social communication interventions.

    PubMed

    Gulsrud, Amanda C; Hellemann, Gerhard S; Freeman, Stephanny F N; Kasari, Connie

    2014-04-01

    This study follows 40 children who were participants in a randomized controlled early intervention trial (Kasari et al.) from early childhood (2-5 years of age) to elementary school age (8-10 years). To fully utilize the available longitudinal data, the general linear mixed model was the primary analytical approach. The growth trajectories of joint attention skills (pointing, coordinated joint looking, and showing) and expressive language outcomes in these children were estimated based on five time points during the measurement period. The children were grouped by diagnosis at the last follow-up (autism, autism spectrum disorder (ASD), no diagnosis) and by their original treatment group assignment (joint attention, symbolic play, control), and differences between these groups were evaluated. Results showed that joint attention skills of coordinated joint looking and showing increased over time, and pointing to share interest increased over the first year measured and decreased thereafter. These trajectories were influenced by both original treatment assignment and diagnostic status at follow-up. In addition, a cross-lagged panel analysis revealed a causal relationship between early pointing and later language development. This study highlights the longitudinal and developmental importance of measures of early core deficits in autism, and suggests that both treatment and ASD symptomatology may influence growth in these skills over time. PMID:24550145

  6. Ten-Year Echo/Doppler Determination of the Benefits of Aerobic Exercise after the Age of 65 Years

    PubMed Central

    Muster, Alexander J.; Kim, Hyunggun; Kane, Bonnie; McPherson, David D.

    2011-01-01

    As the human lifespan becomes progressively extended, potential health-related effects of intense aerobic exercise after age 65 need evaluation. This study evaluates the cardiovascular (CV), pulmonary, and metabolic effects of competitive distance running on age-related deterioration in men between 69 (±3) and 77 (±2) years (mean ±SD). Twelve elderly competitive distance runners (ER) underwent oxygen consumption and echo/Doppler treadmill stress testing (Balke protocol) for up to 10 years. Twelve age-matched sedentary controls (SC) with no history of CV disease were similarly tested and the results compared for the initial three series of the study. CV data clearly separated the ER from SC. At entry, resting and maximal heart rate, systolic/diastolic blood pressure, peak oxygen consumption (VO2max), and E/A ratio of mitral inflow were better in the ER (P < 0.05 vs. SC). With aging, ER had a less deterioration of multiple health parameters. Exceptions were VO2max and left ventricular diastolic function (E/A, AFF, IVRT) that decreased (P < 0.05, Year 10 vs. Year 1). Health advantages of high-level aerobic exercise were demonstrated in the ER when compared to SC. Importantly, data collected in ER over 10 years confirm the benefit of intensive exercise for slowing several negative effects of aging. However, the normative drop of exercise capacity in the seventh and eighth decades reduces the potential athleticism plays in prevention of CV events. PMID:19765066

  7. Ten-year echo/doppler determination of the benefits of aerobic exercise after the age of 65 years.

    PubMed

    Muster, Alexander J; Kim, Hyunggun; Kane, Bonnie; McPherson, David D

    2010-01-01

    As the human lifespan becomes progressively extended, potential health-related effects of intense aerobic exercise after age 65 need evaluation. This study evaluates the cardiovascular (CV), pulmonary, and metabolic effects of competitive distance running on age-related deterioration in men between 69 (+/-3) and 77 (+/-2) years (mean +/- SD). Twelve elderly competitive distance runners (ER) underwent oxygen consumption and echo/Doppler treadmill stress testing (Balke protocol) for up to 10 years. Twelve age-matched sedentary controls (SC) with no history of CV disease were similarly tested and the results compared for the initial three series of the study. CV data clearly separated the ER from SC. At entry, resting and maximal heart rate, systolic/diastolic blood pressure, peak oxygen consumption (VO(2max)), and E/A ratio of mitral inflow were better in the ER (P < 0.05 vs. SC). With aging, ER had a less deterioration of multiple health parameters. Exceptions were VO(2max) and left ventricular diastolic function (E/A, AFF, IVRT) that decreased (P < 0.05, Year 10 vs. Year 1). Health advantages of high-level aerobic exercise were demonstrated in the ER when compared to SC. Importantly, data collected in ER over 10 years confirm the benefit of intensive exercise for slowing several negative effects of aging. However, the normative drop of exercise capacity in the seventh and eighth decades reduces the potential athleticism plays in prevention of CV events. PMID:19765066

  8. Ten years and 100,000 participants later: occupational and other factors influencing participation in US Gulf War health registries.

    PubMed

    Smith, Tyler C; Smith, Besa; Ryan, Margaret A K; Gray, Gregory C; Hooper, Tomoko I; Heller, Jack M; Dalager, Nancy A; Kang, Han K; Gackstetter, Gary D

    2002-08-01

    For more than a decade after the Gulf War, there has been concern that wartime exposures have resulted in significant morbidity among Gulf War veterans. After the end of the war, the Department of Veterans Affairs (VA) and the Department of Defense (DoD) initiated health registries to provide systematic clinical evaluations of Gulf War veterans who chose to participate. By September 1999, there were 32,876 participants in the DoD Comprehensive Clinical Evaluation Program and 70,385 participants in the VA Gulf War Registry Health Examination Program. We identified demographic and military service factors, as well as potential war-related exposures associated with subsequent registry participation after 10 years of observation. Veterans potentially exposed to oil well fire smoke, those near Khamisiyah, Reserve and National Guard, Army veterans, and veterans in the theater of operations during intense combat periods were most likely to elect to participate in a registry. These findings support the hypothesis that certain occupational factors and wartime exposures may influence subsequent health care-seeking behavior. PMID:12185797

  9. Ten years of integrated care: backwards and forwards. The case of the province of Québec, Canada

    PubMed Central

    Vedel, Isabelle; Monette, Michele; Beland, François; Monette, Johanne; Bergman, Howard

    2011-01-01

    Introduction Québec’s rapidly growing elderly and chronically ill population represents a major challenge to its healthcare delivery system, attributable in part to the system’s focus on acute care and fragmented delivery. Description of policy practice Over the past few years, reforms have been implemented at the provincial policy level to integrate hospital-based, nursing home, homecare and social services in 95 catchment areas. Recent organizational changes in primary care have also resulted in the implementation of family medicine groups and network clinics. Several localized initiatives were also developed to improve integration of care for older persons or persons with chronic diseases. Conclusion and discussion Québec has a history of integration of health and social services at the structural level. Recent evaluations of the current reform show that the care provided by various institutions in the healthcare system is becoming better integrated. The Québec health care system nevertheless continues to face three important challenges in its management of chronic diseases: implementing the reorganization of primary care, successfully integrating primary and secondary care at the clinical level, and developing effective governance and change management. Efforts should focus on strengthening primary care by implementing nurse practitioners, developing a shared information system, and achieving better collaboration between primary and secondary care. PMID:21677842

  10. Congenital Kyphoscoliosis in Monozygotic Twins: Ten-Year Follow-up Treated by Posterior Vertebral Column Resection (PVCR)

    PubMed Central

    Chang, Dong-Gune; Yang, Jae Hyuk; Lee, Jung-Hee; Kim, Young-Hoon; Kim, Jin-Hyok; Suh, Seung-Woo; Ha, Kee-Yong; Suk, Se-Il

    2016-01-01

    Abstract The etiology of congenital scoliosis and its development remains unclear and has not yet been fully identified, even there are theories that congenital scoliosis could be derived from the failure of formation or failure of segmentation, which are etiologically heterogeneous with genetic, epigenetic, and environmental factors contributing to their occurrence. We reported a case of long-term follow-up after posterior vertebral column resection (PVCR) in both identical twins with similar congenital kyphoscoliosis at thoracolumbar levels. Twin I had been noticed by his parents to have asymmetry of his back at age 5 years, but no treatment was given. Twin II was first noticed to have a spinal problem at 11 years of age by his parents. Overtime, spine of both twins became further deviated to the left with kyphosis and was referred to our hospital. Both monozygotic twins were treated by PVCR and satisfactory results were demonstrated at 10-year follow-up. This case is the first report on the surgical treatment with PVCR, almost simultaneously, in both identical twins who had similar congenital vertebral anomalies causing kyphoscoliosis. Both identical twins with congenital kyphoscoliosis had undergone surgical correction by PVCR, anterior support with a mesh cage and posterior fusion using pedicle screws at the age of 14 years and achieved a satisfactory correction and a stable spine without curve progression with 10-year follow-up. PMID:27124052

  11. Evolution of the 3-dimensional video system for facial motion analysis: ten years' experiences and recent developments.

    PubMed

    Tzou, Chieh-Han John; Pona, Igor; Placheta, Eva; Hold, Alina; Michaelidou, Maria; Artner, Nicole; Kropatsch, Walter; Gerber, Hans; Frey, Manfred

    2012-08-01

    Since the implementation of the computer-aided system for assessing facial palsy in 1999 by Frey et al (Plast Reconstr Surg. 1999;104:2032-2039), no similar system that can make an objective, three-dimensional, quantitative analysis of facial movements has been marketed. This system has been in routine use since its launch, and it has proven to be reliable, clinically applicable, and therapeutically accurate. With the cooperation of international partners, more than 200 patients were analyzed. Recent developments in computer vision--mostly in the area of generative face models, applying active--appearance models (and extensions), optical flow, and video-tracking-have been successfully incorporated to automate the prototype system. Further market-ready development and a business partner will be needed to enable the production of this system to enhance clinical methodology in diagnostic and prognostic accuracy as a personalized therapy concept, leading to better results and higher quality of life for patients with impaired facial function. PMID:21734549

  12. Changes in contraceptive practice in a multiracial urban-based community over a ten-year period.

    PubMed

    Raman, S; Kishen, D; Hamidah, K; Ang, E S

    1992-06-01

    There have been changes in the national policy regarding population growth in Malaysia from 1982. This report studies the changes in contraceptive practice among the three racial groups in this country, i.e. Malays, Chinese and Indians, over a 5-year period with an interval of 10 years. This is a retrospective study based on the attendance at the same family planning clinic in an urban setting. The striking change noted is the change in the racial composition of contraceptive usage in the two study periods with a shift from the Chinese being predominant in 1975-1979 to Malays in 1985-1989. There was no change among the numbers of Indians using contraception. The results also reveal a significant trend of change for users of the pill and those undergoing sterilization. There were no significant changes in IUD, condom and injectable usage. The study demonstrates how national policies, level of education and rural urban migration can significantly alter contraceptive practice. PMID:1519495

  13. Responding to information about children in adversity: ten years of a differential response model in Western Australia.

    PubMed

    Harries, Maria; Cant, Rosemary L; Bilson, Andy; Thorpe, David

    2015-01-01

    This article uses a comprehensive database about children in adversity collected over the 16-year period from 1990 to 2005 in the state of Western Australia. The focus of this interrogation is the effect of major changes in responses to information about children brought to the attention of the Western Australian statutory authority in a 10-year period during this 16 years. The initiative for these changes was termed New Directions, and its associated policy and practice changes were aimed at differentiating information expressing concerns about children and families from allegations of child maltreatment. They emphasized the provision of supportive and empowering services to families experiencing difficulties - a form of differential response to children in adversity. The article covers the period leading up to the policy and practice change and the 10 years during which these changes were implemented. It examines some effects of the new policy and comments on whether the changes resulted in missed opportunities to protect children from harm, which in turn, might have led to higher rates of re-reporting. The authors present an overall picture of the nature of the information accepted by the statutory authority and how the interpretation of that information might have affected subsequent outcomes for children. In doing so, it shows that the policy and consequential practice changes associated with a differential response mechanism had long lasting positive effects that, despite dire warnings, did not compromise the protection of the small group of children identified as requiring protective interventions. PMID:25043920

  14. Ten years of medical imaging standardization and prototypical implementation: the DICOM standard and the OFFIS DICOM toolkit (DCMTK)

    NASA Astrophysics Data System (ADS)

    Eichelberg, Marco; Riesmeier, Joerg; Wilkens, Thomas; Hewett, Andrew J.; Barth, Andreas; Jensch, Peter

    2004-04-01

    In 2003, the DICOM standard celebrated its 10th anniversary. Aside from the standard itself, also OFFIS" open source DICOM toolkit DCMTK, which has continuously followed the development of DICOM, turns 10 years old. On this occasion, this article looks back at the main standardization efforts in DICOM and illustrates related developments in DCMTK. Considering the development of the DICOM standard, it is possible to distinguish several phases of progress. Within the first phase at the beginning of the 1990s, basic network services for image transfer and retrieval were being introduced. The second phase, in the mid 1990s, was characterized by advances in the specification of a file format and of regulations for media interchange. In the later but partly parallel third phase, DICOM predominantly dealt with the problem of optimizing the workflow within imaging departments. As a result of the fact that it was now possible to exchange images between different systems, efforts concerning image display consistency followed in a fourth phase at the end of the 1990s. In the current fifth phase, security enhancements are being integrated into the standard. In another phase of progress, which took place over a relatively long time period concurrently to the other mentioned phases, DICOM Structured Reporting was developed.

  15. Ten-Year Follow-up of a Reused Kidney Graft for Transplant Using Sirolimus for Maintenance Immunosuppression.

    PubMed

    Lugo-Baruqui, J; Burke, G W; Guerra, G; Ruiz, P; Ciancio, G

    2015-12-01

    Reused kidney grafts have been transplanted with successful outcomes, though not widely performed in the Unites States. We present the case of a reused kidney graft with 10-year follow-up. The first donation was from a patient who died from a cerebrovascular accident and whose organs were used for a simultaneous pancreas and kidney transplant. After 5 years, the patient died and kidney was considered for donation and reuse. The patient had a virtual crossmatch with the first donor and a complement-dependent and flow-dependent crossmatch with the second donor. Long-term immune suppression was kept with a calcineurin-inhibitor-free regimen with sirolimus to prevent further damage from the first recipient. Control kidney biopsy showed steady progression of previous CNI toxicity without further damage. We describe the immunological basis of reused graft, the technical aspects of procurement and transplantation, as well as the use of Mammalian target of rapamycin for maintenance immunosuppression with good long-term results. Reused kidney grafts can be a good source of kidney grafts when adequate selection between donor and recipients is made and immunosuppression protocol is tailored to the preexisting damage to the original graft. PMID:26707333

  16. Ten years after entry into force of the Stockholm Convention: What do air monitoring data tell about its effectiveness?

    PubMed

    Wöhrnschimmel, Henry; Scheringer, Martin; Bogdal, Christian; Hung, Hayley; Salamova, Amina; Venier, Marta; Katsoyiannis, Athanasios; Hites, Ronald A; Hungerbuhler, Konrad; Fiedler, Heidelore

    2016-10-01

    More than a decade ago, the Stockholm Convention on Persistent Organic Pollutants (POPs), one of the multilateral environmental agreements administered by the United Nations Environment Programme (UNEP), entered into force. The objective of this Convention is to protect human health and the environment by controlling the releases of POPs. According to its Article 16, the effectiveness of the Stockholm Convention shall be evaluated using comparable monitoring data on the presence of POPs as well as their regional and global environmental transport. Here, we present a time series analysis on atmospheric POP concentrations from 15 monitoring stations in North America and Europe that provide long-term data and have started operations between 1990 and 2003. We systematically searched for temporal trends and significant structural changes in temporal trends that might result from the provisions of the Stockholm Convention. We find that such structural changes do occur, but they are related mostly to effects of national regulations enforced prior to the implementation of the Stockholm Convention, rather than to the enforcement of the provisions laid out in the Convention. One example is that concentrations of polychlorinated biphenyls, many of which started to decrease rapidly during the 1990s. Also effects of chemical transport and fate, for instance the re-volatilization of POPs from secondary sources, are thought to be a cause of some of the observed structural changes. We conclude that a decade of air monitoring data has not been sufficient for detecting general and statistically significant effects of the Stockholm Convention. Based on these lessons, we present recommendations for the future operation of existing monitoring programs and advocate for a stricter enforcement of the provisions of the Stockholm Convention, in the current absence of proof for its effectiveness. PMID:27015905

  17. Unemployment in TB Patients – Ten-Year Observation at Regional Center of Pulmonology in Bydgoszcz, Poland

    PubMed Central

    Przybylski, Grzegorz; Dąbrowska, Anita; Pilaczyńska-Cemel, Marta; Krawiecka, Dorota

    2014-01-01

    Background Tuberculosis (TB) affects the poorest of the poor and is an example of a disease that can contribute to the “disease-poverty trap”. The variable epidemiological situation is associated with social risk factors, such as unemployment, which may favor the occurrence of this disease. The aim of this study was to analyze unemployment as a factor that can influence the incidence and course of the disease. Material/Methods We analyzed TB patients with confirmed status of employment or unemployment admitted to the Regional Center of Pulmonology in Bydgoszcz in during the years 2001 to 2010. Out of 1130 patients, 604 were unemployed and the other confirmed their employment. Results The unemployed patients were mostly single men over age 40, with a low level of education, and living in a city. We observed that the proportions of smokers and alcohol abusers were significantly higher among the unemployed patients. The advanced radiological lesions, smear-positive pulmonary TB, and extra-pulmonary sites were diagnosed significantly more often in this group. The rate of death in the course of hospitalization was significantly higher in the group of unemployed patients. Conclusions Unemployment among TB patients is a serious problem. We found that more advanced radiological lesions were associated with more frequent treatment interruptions and a higher rate of death in the course of hospitalization. Increased efforts are needed to reduce and eliminate the problem of unemployment among patients with TB. This may, indirectly, contribute to a decrease in notifications of TB cases and improve treatment outcomes. PMID:25362504

  18. Do unexplained symptoms predict anxiety or depression? Ten-year data from a practice-based research network

    PubMed Central

    van Boven, Kees; Lucassen, Peter; van Ravesteijn, Hiske; Hartman, Tim olde; Bor, Hans; van Weel-Baumgarten, Evelyn; van Weel, Chris

    2011-01-01

    Background Unexplained symptoms are associated with depression and anxiety. This association is largely based on cross-sectional research of symptoms experienced by patients but not of symptoms presented to the GP. Aim To investigate whether unexplained symptoms as presented to the GP predict mental disorders. Design and setting Cross-sectional and longitudinal analysis of data from a practice-based research network of GPs, the Transition Project, in the Netherlands. Method All data about contacts between patients (n = 16 000) and GPs (n = 10) from 1997 to 2008 were used. The relation between unexplained symptoms episodes and depression and anxiety was calculated and compared with the relation between somatic symptoms episodes and depression and anxiety. The predictive value of unexplained symptoms episodes for depression and anxiety was determined. Results All somatoform symptom episodes and most somatic symptom episodes are significantly associated with depression and anxiety. Presenting two or more symptoms episodes gives a five-fold increase of the risk of anxiety or depression. The positive predictive value of all symptom episodes for anxiety and depression was very limited. There was little difference between somatoform and somatic symptom episodes with respect to the prediction of anxiety or depression. Conclusion Somatoform symptom episodes have a statistically significant relation with anxiety and depression. The same was true for somatic symptom episodes. Despite the significant odds ratios, the predictive value of symptom episodes for anxiety and depression is low. Consequently, screening for these mental health problems in patients presenting unexplained symptom episodes is not justified in primary care. PMID:21801510

  19. Estimation of Ten-Year Survival of Patients with Pulmonary Tuberculosis Based on the Competing Risks Model in Iran

    PubMed Central

    Kazempour-Dizaji, Mehdi; Tabarsi, Payam; Zayeri, Farid

    2016-01-01

    Background: Tuberculosis (TB) is a chronic bacterial disease, which despite the presence of effective drug strategies, still remains a serious health problem worldwide. Estimation of survival rate is an appropriate indicator for prognosis in patients with pulmonary TB. Therefore, this research was designed with the aim of accurate estimation of the survival of patients by taking both the death event and relapse into consideration. Materials and Methods: Based on a retrospective cohort study, information of 2,299 patients with pulmonary TB that had been referred to and treated in Masih Daneshvari Hospital from 2005 to 2015 was reviewed. To estimate the survival of patients with pulmonary TB, the competing risks model, which considered death and relapse as competing events, was used. In addition, the effect of factors affecting the cumulative incidence function (CIF) of death event and relapse was also examined. Results: The effect of risk factors on the CIF of death events and relapse showed that patients’ age, marital status, contact with TB patients, adverse effect of drugs, imprisonment and HIV positivity were factors that affected the CIF of death. Meanwhile, sex, marital status, imprisonment and HIV positivity were factors affecting the CIF of relapse (P <0.05). Considering death and relapse as competing events, survival estimation in pulmonary TB patients showed that survival in this group of patients in the first, third, fifth and tenth year after treatment was 39%, 14%, 7% and 0%, respectively. Conclusion: The use of competing risks model in survival analysis of patients with pulmonary TB with consideration of competing events, enables more accurate estimation of survival. PMID:27403177

  20. Ten-year experience in the management of distal ureteral stones greater than 10 mm in size

    PubMed Central

    DELL’ATTI, L.; PAPA, S.

    2016-01-01

    Aim Extracorporeal shock wave lithotripsy (ESWL) and semirigid ureteroscopy lithotripsy (URSL) have become standards of treatment for ureteral calculi. The aim of this retrospective study was to compare ESWL vs. URSL in terms of safety and efficacy for treatment of large distal ureteral stones ≥ 1cm. Patients and Methods This investigation assessed 637 patients with distal ureteral stones (10 to 15mm in size). 313 in the ESWL group were treated on an outpatient basis using the LithoDiamond machine without anaesthesia. URSL was performed in 324 patients with a 6–8 Fr semirigid ureterorenoscope and YAG laser under spinal anaesthesia. A successful outcome was defined as the patient being stone free 1 month after treatment. For all patients the parameters, including stone-free rate, operation time, complications, were inserted retrospectively in this study after review of medical records and operating room logs. Results The stone-free rate after URSL was 77.5% and 45.4% after ESWL treatment (p<0.001). The mean operative time between two groups was 74.7±9.8 for URSL group and 38.3±7.6 for ESWL group. The average number of office visits was 4.2 and 2.6 in patients treated with ESWL and URSL, respectively. Double j stents were inserted in 28.7% of patients. Twenty-one patients needed rehospitalisations for major complications. However, the differences in the overall complication rate were not statistically significant, with a rate of 16.3% for URSL and 14.4% for ESWL (p=0.246). Conclusion We have shown that URSL has enough safety and efficacy for the treatment of distal ureteral stones ≥ 1cm. URSL is associated with higher stone clearance rate as compared with ESWL. PMID:27142822

  1. Directly Observed Treatment Short-course (DOTS) for tuberculosis control program in Gambella Regional State, Ethiopia: ten years experience

    PubMed Central

    2014-01-01

    Background Tuberculosis is still the leading cause of illness in the world which accounted for 2.5% of the global burden of disease, and 25% of all avoidable deaths in developing countries. The aim of study was to assess impact of DOTS strategy on tuberculosis case finding and treatment outcome in Gambella Regional State, Ethiopia from 2003 up to 2012 and from 2002 up to 2011, respectively. Methods Health facility-based retrospective study was conducted. Data were collected and reported in quarterly basis using WHO reporting format for TB case finding and treatment outcome from all DOTS implementing health facilities in all zones of the region to Federal Ministry of Health. Results A total of 10024 all form of TB cases had been registered between the periods from 2003 up to 2012. Of them, 4100 (40.9%) were smear-positive pulmonary TB, 3164 (31.6%) were smear-negative pulmonary TB and 2760(27.5%) had extra-pulmonary TB. Case detection rate of smear-positive pulmonary TB had increased from 31.7% to 46.5% from the total TB cases and treatment success rate increased from 13% to 92% with average mean value of being 40.9% (SD = 0.1) and 55.7% (SD = 0.28), respectively for the specified year periods. Moreover, the average values of treatment defaulter and treatment failure rates were 4.2% and 0.3%, respectively. Conclusion It is possible to achieve the recommended WHO target which is 70% of CDR for smear-positive pulmonary TB, and 85% of TSR as it was already been fulfilled the targets for treatments more than 85% from 2009 up to 2011 in the region. However, it requires strong efforts to enhance case detection rate of 40.9% for smear-positive pulmonary TB through implementing alternative case finding strategies. PMID:24444379

  2. Ten years of elemental atmospheric metal fallout and Pb isotopic composition monitoring using lichens in north-eastern France

    NASA Astrophysics Data System (ADS)

    Cloquet, Christophe; Estrade, Nicolas

    2016-04-01

    We report on the chemical and Pb isotopic compositions of epiphytic lichens collected from small tree branches in the urban area of the city of Metz (NE France). Lichens were collected in five different years between 2001 and 2009. The data are first compared year to year in order to document any temporal changes and trends in metal atmospheric fallout. The area studied was then subdivided into different zones on the basis of land-use (urban, suburban, rural and industrial) in order to determine potential spatial gradients. The median concentrations and enrichment factors (EF, normalized to Al) of Pb and other metals (Cu, Zn, Cd, Ni, Cr, Hg, Fe) in lichens from the urban, suburban, and rural zones show no systematic variation between 2001 and 2008. However, the metal EFs show spatial variation and are generally highest in the urban area and lowest in the rural area. Lichens within the industrial zone (collected in 2009), which is dominated by steel industries, are richest in Al, Fe, Cr, Pb, and Zn. Although the Al concentration is high in these lichens, the EFs for the cited metals are several times higher than those measured in lichens from the other three zones. No significant differences were noted for Hg, Cd, Cu and or Ni. Lead isotopic compositions measured in lichens may be highly variable from year to year and from zone to zone. The variation is primarily interpreted to result from mixing between: (i) Pb added to gasoline (and recycled through re-emission of road dust in the atmosphere); (ii) regional industrial Pb from long-range transportation and/or mixed with urban Pb; and (iii) local industrial Pb. The median isotopic compositions of individual zones are distinct, suggesting variable mixing of these three sources. The annual variations show that 2001 was most affected by gasoline Pb, whereas 2003 and 2006 were more affected by the local steel industry.

  3. The pollution removal and stormwater reduction performance of street-side bioretention basins after ten years in operation.

    PubMed

    Lucke, Terry; Nichols, Peter W B

    2015-12-01

    This study evaluated the pollution removal and hydrologic performance of five, 10-year old street-side bioretention systems. The bioretention basins were subjected to a series of simulated rainfall events using synthetic stormwater. Four different pollution concentrations were tested on three of the bioretention basins. The four concentrations tested were: A) no pollution; B) typical Australian urban pollutant loads; C) double the typical pollution loads, and; D) five times the typical pollution loads. Tests were also undertaken to determine the levels of contaminant and heavy metals build-up that occurred in the filter media over the 10 year operational life of the bioretention systems. Although highly variable, the overall hydrological performance of the basins was found to be positive, with all basins attenuating flows, reducing both peak flow rates and total outflow volumes. Total suspended solids removal performance was variable for all tests and no correlation was found between performance and dosage. Total nitrogen (TN) removal was positive for Tests B, C and D. However, the TN removal results for Test A were found to be negative. Total phosphorus (TP) was the only pollutant to be effectively removed from all basins for all four synthetic stormwater tests. The study bioretention basins were found to export pollutants during tests where no pollutants were added to the simulated inflow water (Test A). Heavy metal and hydrocarbon testing undertaken on the bioretention systems found that the pollution levels of the filter media were still within acceptable limits after 10 years in operation. This field study has shown bioretention basin pollution removal performance to be highly variable and dependant on a range of factors including inflow pollution concentrations, filter media, construction methods and environmental factors. Further research is required in order to fully understand the potential stormwater management benefits of these systems. PMID:26254078

  4. Ten years of elemental atmospheric metal fallout and Pb isotopic composition monitoring using lichens in northeastern France

    NASA Astrophysics Data System (ADS)

    Cloquet, Christophe; Estrade, Nicolas; Carignan, Jean

    2015-09-01

    We report on the chemical and Pb isotopic compositions of epiphytic lichens collected from small tree branches in the urban area of the city of Metz (NE France). Lichens were collected in five different years between 2001 and 2009. The data are first compared year to year in order to document any temporal change and trend in metal atmospheric fallout. The area studied was then subdivided into different zones on the basis of land use (urban, suburban, rural and industrial) in order to determine potential spatial gradients. The median concentrations and enrichment factors (EF, normalized to Al) of Pb and other metals (Cu, Zn, Cd, Ni, Cr, Hg, Fe) in lichens from the urban, suburban, and rural zones show no systematic variation between 2001 and 2008. However, the metal EFs show spatial variation and are generally highest in the urban area and lowest in the rural area. Lichens within the industrial zone (collected in 2009), which is dominated by steel industries, are richest in Al, Fe, Cr, Pb, and Zn. Although the Al concentration is high in these lichens, the EFs for the cited metals are several times higher than those measured in lichens from the other three zones. No significant differences were noted for Hg, Cd, Cu and or Ni. Pb isotopic compositions measured in lichens may be highly variable from year to year and from zone to zone. The variation is primarily interpreted to result from mixing between: (i) Pb added to gasoline (and recycled through re-emission of road dust in the atmosphere); (ii) regional industrial Pb from long-range transportation and/or mixed with urban Pb; and (iii) local industrial Pb. The median isotopic compositions of individual zones are distinct, suggesting variable mixing of these three sources. The annual variations show that 2001 was most affected by gasoline Pb, whereas 2003 and 2006 were more affected by the local steel industry.

  5. A review of the activities of the IAG working group on geomorphosites over the last ten years

    NASA Astrophysics Data System (ADS)

    Reynard, Emmanuel; Coratza, Paola

    2013-04-01

    During the last two decades a renewed interest emerged in the scientific community for geoheritage, geoconservation and geotourism research. This was the reason for the International Association of Geomorphologists (IAG) for creating a specific working group on geomorphosites in 2001, with the aim to improve knowledge and scientific research on the definition, assessment, cartography, promotion and conservation of geomorphological heritage. The working group is chaired by the two authors, experiences were shared during several workshops and international conferences, and results were collected in several special publications (http://www.geomorph.org/wg/wggs.html). Several intensive courses for Master and PhD students were also organized and a book was published, dedicated particularly to Master and PhD students working on geomorphosite issues (Reynard et al., 2009). This contribution proposes a review of the working group activities since 2001 that focused on four main domains: (1) Definition and conceptualization. Geomorphosites are a type of geosite that is portions of the geosphere that present a particular importance for the comprehension of the Earth's history. Geomorphosites have to be considered as the result of human valuation. Conceptualization related to the value of geomorphosites is still in course. Nevertheless, three groups of values can be demonstrated: the scientific value (that is the interest of sites for Earth history and for the history and epistemology of geomorphology), several additional values (aesthetic, ecological, and cultural in a broad sense), and use and management values, that can be divided in three groups (educational value, economic value, including the tourist value, and protection). The scientific and additional value can be considered as intrinsic values, whereas the management and use value are to be related to extrinsic or societal values. (2) Assessment. Several methods, based on the measurement of specific features of

  6. Inborn errors of metabolism identified via newborn screening: Ten-year incidence data and costs of nutritional interventions for research agenda planning.

    PubMed

    Therrell, Bradford L; Lloyd-Puryear, Michele A; Camp, Kathryn M; Mann, Marie Y

    2014-01-01

    Inborn errors of metabolism (IEM) are genetic disorders in which specific enzyme defects interfere with the normal metabolism of exogenous (dietary) or endogenous protein, carbohydrate, or fat. In the U.S., many IEM are detected through state newborn screening (NBS) programs. To inform research on IEM and provide necessary resources for researchers, we are providing: tabulation of ten-year state NBS data for selected IEM detected through NBS; costs of medical foods used in the management of IEM; and an assessment of corporate policies regarding provision of nutritional interventions at no or reduced cost to individuals with IEM. The calculated IEM incidences are based on analyses of ten-year data (2001-2011) from the National Newborn Screening Information System (NNSIS). Costs to feed an average person with an IEM were approximated by determining costs to feed an individual with an IEM, minus the annual expenditure for food for an individual without an IEM. Both the incidence and costs of nutritional intervention data will be useful in future research concerning the impact of IEM disorders on families, individuals and society. PMID:25085281

  7. Inborn errors of metabolism identified via newborn screening: Ten-year incidence data and costs of nutritional interventions for research agenda planning✰

    PubMed Central

    Therrell, Bradford L.; Lloyd-Puryear, Michele A.; Camp, Kathryn M.; Mann, Marie Y.

    2014-01-01

    Inborn errors of metabolism (IEM) are genetic disorders in which specific enzyme defects interfere with the normal metabolism of exogenous (dietary) or endogenous protein, carbohydrate, or fat. In the U.S., many IEM are detected through state newborn screening (NBS) programs. To inform research on IEM and provide necessary resources for researchers, we are providing: tabulation of ten-year state NBS data for selected IEM detected through NBS; costs of medical foods used in the management of IEM; and an assessment of corporate policies regarding provision of nutritional interventions at no or reduced cost to individuals with IEM. The calculated IEM incidences are based on analyses of ten-year data (2001–2011) from the National Newborn Screening Information System (NNSIS). Costs to feed an average person with an IEM were approximated by determining costs to feed an individual with an IEM, minus the annual expenditure for food for an individual without an IEM. Both the incidence and costs of nutritional intervention data will be useful in future research concerning the impact of IEM disorders on families, individuals and society. PMID:25085281

  8. Ten years of OMI observations: scientific highlights and impacts on the new generation of UV/VIS satellite instrumentation

    NASA Astrophysics Data System (ADS)

    Levelt, Pieternel; Veefkind, Pepijn; Bhartia, Pawan; Joiner, Joanna; Tamminen, Johanna; OMI Science Team

    2014-05-01

    contributes to several operational services, including volcanic plume warning systems for aviation, UV forecasts and the air quality forecasts. In this invited talk an overview will be given of unique findings and new scientific results based on OMI data over the last 10 years and which unique OMI instrument features are recurring in the new generation of UV/VIS satellite instrumentation in Europe, USA and Asia.

  9. Horizontal Deformation Rates Measured by Ten Years of GPS Observations on the Socorro Magma Body, New Mexico, USA

    NASA Astrophysics Data System (ADS)

    George, N. K.; Murray, M. H.; Roy, M.; Newman, A. V.; Love, D. W.; Chamberlin, R. M.

    2012-12-01

    The Socorro magma body (SMB), located near Socorro, New Mexico, USA within the central Rio Grande Rift (RGR), has been identified by seismic studies as a subhorizontal reflector at a depth of 19 km, interpreted as a mid-crustal igneous intrusive body extending ~70 km N-S and ~45 km E-W. Geodetic leveling and InSAR measurements have identified an unevenly distributed pattern of uplift with averaged rates of ~2-4 mm/yr centered in the northern portion of the SMB, and decreasing to near zero in the southern portion. Trilateration studies in 1980 and 1985 over the southern half of the SMB failed to identify horizontal deformation in excess of the ~ 1 mm/yr E-W extension rate inferred by geological studies of the RGR. We measure horizontal deformation rates using continuous and survey-mode GPS observations beginning in 2002 with the installation of nine bedrock monuments in two approximately E-W transects across the central and northern SMB. In 2004, a transect of three additional bedrock monuments was added across the southern SMB, and two continuous GPS stations were installed along the central SMB transect in 2005. We estimate horizontal and vertical deformation using observations from campaign GPS surveys undertaken in 2002, 2003, 2004, 2006, and 2011, and available continuous GPS observations from the SMB, IGS, NGS CORS, and EarthScope-PBO and PBO-RGR networks for 2002 to 2012. We use the GAMIT/GLOBK processing software and estimate deformation relative to the Stable North American Reference Frame (SNARF) realized by the PBO network. We observe significant horizontal velocities of ~1-1.5 mm/yr and vertical velocities of ~2 mm/yr in a radial dilatational pattern, located in the region of maximum uplift identified by previous studies. These results are consistent with an inflationary magmatic source and the increased resolution of horizontal velocities will, when combined with vertical velocity data, allow us to develop a more complete model of the actively deforming

  10. A Ten-Year Retrospective Look at the NSF/GEO Opportunities for Enhancing Diversity in the Geosciences (OEDG) Program

    NASA Astrophysics Data System (ADS)

    Karsten, J. L.

    2013-12-01

    The Opportunities for Enhancing Diversity in the Geosciences (OEDG) program - established in 2002 by the National Science Foundation's Directorate for Geosciences (GEO) - has been a mainstay in GEO's efforts to broaden participation of traditionally underrepresented minorities in the geosciences. The primary goal of the OEDG program has been to engage a diverse population of students in learning about - and pursuing advanced degrees and careers in - the geosciences. Raising public awareness of the importance and relevance of the geosciences among diverse audiences has been a secondary goal. During the past decade, the OEDG program has supported a variety of planning grants, proof-of-concept projects, and larger full-scale implementation efforts across the U.S. These projects have contributed a rich array of culturally-tailored resources for learning about geoscience career pathways and opportunities to participate in geoscience research experiences. OEDG has also developed networking and mentoring programs tailored for diverse student audiences, as well as the educators who work with them, and has helped to build capacity in the geosciences at minority-serving institutions. Perhaps the most important legacy of the OEDG program has been the establishment of an enthusiastic and effective community of educators, administrators, students and organizations dedicated to increasing diversity in the geosciences. Evaluation data collected for individual OEDG projects has helped to improve the impact of specific projects and increase our understanding of which approaches are more successful in achieving OEDG program goals. In addition, GEO has supported a decade-long, program-wide evaluation of the OEDG portfolio through a contract to the American Institutes for Research (AIR). Synthesis of results from both the project- and program-level evaluation activities has identified evidence-based 'best practices' that are essential for achieving success in broadening participation

  11. Ten-Year Locoregional Recurrence Risks in Women With Nodal Micrometastatic Breast Cancer Staged With Axillary Dissection

    SciTech Connect

    Lupe, Krystine; Truong, Pauline T.; Alexander, Cheryl; Speers, Caroline; Tyldesley, Scott

    2011-12-01

    Purpose: To compare the locoregional recurrence (LRR) rates in patients with nodal mirometastases (pNmic) with those in patients with node-negative (pN0) and macroscopic node-positive (pNmac) breast cancer; and to evaluate the LRR rates according to locoregional treatment of pNmic disease. Methods and Materials: The subjects were 9,616 women diagnosed between 1989 and 1999 with Stage pT1-T2, pN0, pNmic, or pNmac, M0 breast cancer. All women had undergone axillary dissection. The Kaplan-Meier local recurrence, regional recurrence, and LRR rates were compared among those with pN0 (n = 7,977), pNmic (n = 490) and pNmac (n = 1,149) and according to locoregional treatment. Multivariate analysis was performed to identify the significant factors associated with LRR. Results: The median follow-up was 11 years. The 10-year Kaplan-Meier recurrence rate in the pN0, pNmic, and pNmac cohorts was 6.1%, 6.8%, and 8.7% for local recurrence; 3.1%, 6.2%, and 10.3% for regional recurrence; and 8.0%, 11.6%, and 15.2% for LRR, respectively (all p < .001). In the pNmic patients, the 10-year regional recurrence rate was 6.4% with breast-conserving surgery plus breast radiotherapy (RT), 5.4% with breast-conserving surgery plus locoregional RT, 4.6% with mastectomy alone, 11.1% with mastectomy plus chest wall RT, and 10.7% with mastectomy plus locoregional RT. In patients with pNmic disease and age <45 years, Grade 3 histologic features, lymphovascular invasion, nodal ratio >0.25, and estrogen receptor-negative disease, the 10-year LRR rates were 15-20%. On multivariate analysis of the entire cohort, pNmic was associated with greater LRR than Stage pN0 (hazard ratio [HR], 1.6; p = .002). On multivariate analysis of pNmic patients only, age <45 years was associated with significantly greater LRR (HR, 1.9; p = .03), and trends for greater LRR were observed with a nodal ratio >0.25 (HR, 2.0; p = .07) and lymphovascular invasion (HR, 1.7; p = .07). Conclusion: Women with pNmic had a greater

  12. Ten Years of Black Carbon Measurements in the North Atlantic at the Pico Mountain Observatory, Azores (2225m asl)

    NASA Astrophysics Data System (ADS)

    Kumar, S.; Fialho, P. J.; Mazzoleni, L. R.; Olsen, S. C.; Owen, R. C.; Helmig, D.; Hueber, J.; Dziobak, M.; Kramer, L. J.; Mazzoleni, C.

    2012-12-01

    The Pico Mountain Observatory is located in the summit caldera of the Pico mountain, an inactive volcano on the Pico Island in the Azores, Portugal (38.47°N, 28.40°W, Altitude 2225m asl). The Azores are often impacted by polluted outflows from the North American continent and local sources have been shown to have a negligible influence at the observatory. The value of the station stems from the fact that this is the only permanent mountaintop monitoring station in the North Atlantic that is typically located above the marine boundary layer (average MBL heights are below 1200 m and rarely exceed 1300 m) and often receives air characteristic of the lower free troposphere. Measurements of black carbon (BC) mass have been carried out at the station since 2001, mostly in the summer seasons. Here we discuss the BC decadal dataset (2001-2011) collected at the site by using a seven-wavelength AE31 Magee Aethalometer. Measured BC mass and computed Angstrom exponent (AE) values were analysed to study seasonal and diurnal variations. There was a large day-to-day variability in the BC values due to varied meteorological conditions that resulted in different diurnal patterns for different months. The daily mean BC at this location ranged between 0 and ~430 ngm-3, with the most frequently occurring value in the range 0-100 ngm-3. The overall mean for the 10 year period is ~24 ngm-3, with a coefficient of variation of 150%. The BC values exhibited a consistent annual trend being low in winter months and high in summer months, barring year to year variations. To differentiate between BC and other absorbing particles, we analyzed the wavelength dependence of aerosol absorption coefficient and determined a best-fit exponent i.e., the Ångström exponent, for the whole dataset. Visible Ångström exponent (AE: 470-520-590-660 nm) values ranged between 0 and 3.5, with most frequently occurring values in the range 0.85 to 1.25. By making use of the aethalometer light attenuation

  13. College Cheating: Ten Years Later.

    ERIC Educational Resources Information Center

    Diekhoff, George M.; And Others

    1996-01-01

    A follow-up study of college students' (n=474) cheating behaviors looked at extent of cheating, attitudes toward it, characteristics of cheaters/noncheaters, effectiveness of deterrents, and attitude changes from 1984-94. A significant rise in cheating was found, but with less rationalization. An additional 12 variables discriminating cheaters…

  14. Noise control: ten years later

    SciTech Connect

    Seebold, J.G.

    1982-01-01

    Separate abstracts have been prepared for 47 out of 124 papers presented at this conference. The papers include both retrospective and prospective views or noise control engineering and its impact on society. (ACR)

  15. Ten Years of Net Work

    ERIC Educational Resources Information Center

    Anklam, Patti

    2009-01-01

    Purpose: The purpose of this paper is to provide a perspective on the emergence of social media and their adoption as a critical element in knowledge management strategy. Social media are defined as the collection of software tools and web-based applications that are personalized, that is, that communications identify individuals by name and…

  16. Ten year evolution of liposuction.

    PubMed

    Troilius, C

    1996-01-01

    The author very briefly reviews the evolution of liposuction beginning with the pioneering work of Yves-Gerard Illouz, through the contributions of Doctors Toledo, Gasparotti, Klein, and Zocchi. This brief historical review is accompanied by cases demonstrating his experiences with these techniques. PMID:8670395

  17. Ten Years of Grid Cells.

    PubMed

    Rowland, David C; Roudi, Yasser; Moser, May-Britt; Moser, Edvard I

    2016-07-01

    The medial entorhinal cortex (MEC) creates a neural representation of space through a set of functionally dedicated cell types: grid cells, border cells, head direction cells, and speed cells. Grid cells, the most abundant functional cell type in the MEC, have hexagonally arranged firing fields that tile the surface of the environment. These cells were discovered only in 2005, but after 10 years of investigation, we are beginning to understand how they are organized in the MEC network, how their periodic firing fields might be generated, how they are shaped by properties of the environment, and how they interact with the rest of the MEC network. The aim of this review is to summarize what we know about grid cells and point out where our knowledge is still incomplete. PMID:27023731

  18. Results of treatment of patients with advanced stomach cancer treated by combination of low-level laser therapy (LLLT) and other methods: ten-year experience

    NASA Astrophysics Data System (ADS)

    Mikhailov, V. A.

    2000-06-01

    In 1988 we started our investigation on the influence of low-level laser on oncologic patient. Now we have an experience of application of LLLT on more than 700 patients with the confirmed diagnosis of cancer at different stage. We used LLLT on 112 with stomach cancer 4th stage before and after operation and on patients without operating interference. LLLT investigations, with a wavelength of 890 nm, have shown that the laser therapy before operation is most effective. Laser therapy activates the immune system by increasing T-active rosette-formed cells and T-helpers and by decreasing T-suppressor cells. Application of LLLT decreases postoperative complications by 11.86 percent after palliative operations; by 9.63 percent after non-radical operations. It also promotes more rapid restorations of the motility and improves general status of patients by 58.69 percent. Investigations of low-level radiation have shown that the life-span of patients with 4th stage stomach cancer who were treated by laser therapy before surgery was increased by 2.03 percent; for those who were treated by LLLT after surgery it was increased by 1.81 times and by 3.03 times in those who took LLLT without surgery.

  19. From Rumors to Facts: Career Outcomes of English Ph.D.s. Results from the Ph.D.'s Ten Years Later Study.

    ERIC Educational Resources Information Center

    Nerad, Maresi; Cerny, Joseph

    1999-01-01

    This study examines actual employment patterns of Ph.D.s in an effort to provide a basis for policy responses to what is felt to be a continuing crisis in the academic job market for humanities Ph.D.s. The study involved almost 6,000 Ph.D. candidates from 61 doctoral-granting institutions across the United States. Six disciplines were chosen to…

  20. Results of treatment of patients with second- to third-stage breast cancer by combination of low-level laser therapy (LLLT) and surgery: ten-year experience

    NASA Astrophysics Data System (ADS)

    Mikhailov, V. A.; Denisov, I. N.; Frank, George A.; Voltchenko, N. N.

    2000-06-01

    Laser therapy with semiconductor laser was performed on 41 patients with 2nd-3rd stage breast cancer. LLLT was used before surgery and in postoperative during 2 years. LLLT decreased postoperative complications by 15.3 percent and decreased duration of limphorrhea. 86.9 percent of patients with 2nd stage breast cancer survived 10 years after LLLT treatment. For patients with III stage breast cancer treated by LLLT the rate was 83.3 percent. 82.6 percent of patients with 2nd stage treated by LLLT had no recurrences in 10 years period. 77.7 percent of patients with 3RD stage treated by LLLT had no recurrences for the same period of time.

  1. How will the two major Midwest crops respond to global climate change? Results from ten years of investigation at SoyFACE

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Soybean Free Air Concentration Enrichment (SoyFACE) facility is an open-air field "laboratory" for investigating the effects of elevated concentrations of CO2 and ozone, higher temperatures and altered soil water availability on field crops. For over a decade, experiments have examined the produ...

  2. Idaho National Laboratory Ten-year Site Plan (2012 through 2021) -- DOE-NE's National Nuclear Capability -- Developing and Maintaining the INL Infrastructure

    SciTech Connect

    Cal Ozaki

    2010-06-01

    To meet long-term objectives to transform the Idaho National Laboratory (INL), we are providing an integrated, long-term vision of infrastructure requirements that support research, development and demonstration (RD&D) goals outlined in the DOE strategic plans, including the NE Roadmap and reports such as Facilities for the Future of Nuclear Energy Research: A Twenty-year Outlook. The goal of the INL Ten-year Site Plan (TYSP) is to clearly link RD&D mission goals and INL core capabilities with infrastructure requirements (single and multi-program), establish the 10-year end-state vision for INL complexes, identify and prioritize infrastructure and capability gaps, as well as the most efficient and economic approaches to closing those gaps.

  3. Ten-Year Follow-Up of Desarthrodesis of the Knee Joint 41 Years after Original Arthrodesis for a Bone Tumor

    PubMed Central

    Kassem Abdelaal, Ahmed Hamed; Yamamoto, Norio; Hayashi, Katsuhiro; Takeuchi, Akihiko; Miwa, Shinji; Inatani, Hiroyuki; Tsuchiya, Hiroyuki

    2015-01-01

    Introduction. The main indication for knee arthrodesis in tumor surgery is a tumor that requires an extensive resection in which the joint surface cannot be preserved. We report a patient that had knee desarthrodesis 41 years after giant cell tumor resection followed by a knee arthrodesis. This is the longest reported follow-up after desarthrodesis and conversion to total knee arthroplasty (TKA), almost ten years. Case Report. A 71-year-old man with a distal femoral giant cell tumor had undergone a resection of the distal femur and knee arthrodesis using Kuntscher nail in 1962. In July 2003 he experienced gradually increasing pain of his left knee. We performed a desarthrodesis and conversion to TKA in 2005. The postoperative period passed uneventfully as his pain and gait improved, with gradually increasing range of motion (ROM) and no infection. He now walks independently, with no brace or contractures. Conclusion. Desarthrodesis of the knee joint and conversion to TKA are a difficult surgical choice with a high complication risk. However, our patient's life style has improved, he has no pain, and he can ascend and descend stairs more easily. The surgeon has to be very meticulous in selecting a patient for knee arthrodesis and counseling them to realize that their expectations may not be achievable. PMID:26688766

  4. Clinical and radiographic outcomes of acetabular impaction grafting without cage reinforcement for revision hip replacement: a minimum ten-year follow-up study.

    PubMed

    Gilbody, J; Taylor, C; Bartlett, G E; Whitehouse, S L; Hubble, M J W; Timperley, A J; Howell, J R; Wilson, M J

    2014-02-01

    Impaction bone grafting for the reconstitution of bone stock in revision hip surgery has been used for nearly 30 years. Between 1995 and 2001 we used this technique in acetabular reconstruction, in combination with a cemented component, in 304 hips in 292 patients revised for aseptic loosening. The only additional supports used were stainless steel meshes placed against the medial wall or laterally around the acetabular rim to contain the graft. All Paprosky grades of defect were included. Clinical and radiographic outcomes were collected in surviving patients at a minimum of ten years after the index operation. Mean follow-up was 12.4 years (sd 1.5) (10.0 to 16.0). Kaplan-Meier survival with revision for aseptic loosening as the endpoint was 85.9% (95% CI 81.0 to 90.8) at 13.5 years. Clinical scores for pain relief remained satisfactory, and there was no difference in clinical scores between cups that appeared stable and those that appeared radiologically loose. PMID:24493183

  5. Ten years after the crime: Lasting effects of damage from a cruise ship anchor on a coral reef in St. John, U.S. Virgin Islands

    USGS Publications Warehouse

    Rogers, C.S.; Garrison, V.H.

    2001-01-01

    In October 1988, a cruise ship dropped its anchor on a coral reef in Virgin Islands National Park, St. John, creating a distinct scar roughly 128 m long and 3 m wide from a depth of 22 m to a depth of 6 m. The anchor pulverized coral colonies and smashed part of the reef framework. In April 1991, nine permanent quadrats (1 m2) were established inside the scar over a depth range of 9 m to 12.5 m. At that time, average coral cover inside the scar was less than 1%. These quadrats were surveyed again in 1992, 1993, 1994, 1995 and 1998. Recruits of 19 coral species have been observed, with Agaricia agaricites and Porites spp. the most abundant. Quadrats surveyed outside the scar in June 1994 over the same depth range had a higher percent coral cover (mean = 7.4%, SD = 4.5) and greater average size (maximum length) of coral colonies than in quadrats inside the damaged area. Although coral recruits settle into the scar in high densities, live coral cover has not increased significantly in the last 10 yrs, reflecting poor survival and growth of newly settled corals. The relatively planar aspect of the scar may increase the vulnerability of the recruits to abrasion and mortality from shifting sediments. Ten years after the anchor damage occurred, live coral cover in the still-visible scar (mean = 2.6%, SD = 2.7) remains well below the cover found in the adjacent, undamaged reef.

  6. Introduction and enzootic of A/H5N1 in Egypt: Virus evolution, pathogenicity and vaccine efficacy ten years on.

    PubMed

    Abdelwhab, E M; Hassan, M K; Abdel-Moneim, A S; Naguib, M M; Mostafa, A; Hussein, I T M; Arafa, A; Erfan, A M; Kilany, W H; Agour, M G; El-Kanawati, Z; Hussein, H A; Selim, A A; Kholousy, S; El-Naggar, H; El-Zoghby, E F; Samy, A; Iqbal, M; Eid, A; Ibraheem, E M; Pleschka, S; Veits, J; Nasef, S A; Beer, M; Mettenleiter, T C; Grund, C; Ali, M M; Harder, T C; Hafez, H M

    2016-06-01

    It is almost a decade since the highly pathogenic H5N1 avian influenza virus (A/H5N1) of clade 2.2.1 was introduced to Egypt in 2005, most likely, via wild birds; marking the longest endemic status of influenza viruses in poultry outside Asia. The endemic A/H5N1 in Egypt still compromises the poultry industry, poses serious hazards to public health and threatens to become potentially pandemic. The control strategies adopted for A/H5N1 in Egyptian poultry using diverse vaccines in commercialized poultry neither eliminated the virus nor did they decrease its evolutionary rate. Several virus clades have evolved, a few of them disappeared and others prevailed. Disparate evolutionary traits in both birds and humans were manifested by accumulation of clade-specific mutations across viral genomes driven by a variety of selection pressures. Viruses in vaccinated poultry populations displayed higher mutation rates at the immunogenic epitopes, promoting viral escape and reducing vaccine efficiency. On the other hand, viruses isolated from humans displayed changes in the receptor binding domain, which increased the viral affinity to bind to human-type glycan receptors. Moreover, viral pathogenicity exhibited several patterns in different hosts. This review aims to provide an overview of the viral evolution, pathogenicity and vaccine efficacy of A/H5N1 in Egypt during the last ten years. PMID:26917362

  7. Ten Years after the International Committee of Medical Journal Editors’ Clinical Trial Registration Initiative, One Quarter of Phase 3 Pediatric Epilepsy Clinical Trials Still Remain Unpublished: A Cross Sectional Analysis

    PubMed Central

    Lampert, Anette; Hoffmann, Georg F.; Ries, Markus

    2016-01-01

    Introduction Although selective reporting of clinical trial results introduces bias into evidence based clinical decision making, publication bias in pediatric epilepsy is unknown today. Since there is a considerable ambiguity in the treatment of an important and common clinical problem, pediatric seizures, we assessed the public availability of results of phase 3 clinical trials that evaluated treatments of seizures in children and adolescents as a surrogate for the extent of publication bias in pediatric epilepsy. Methods We determined the proportion of published and unpublished study results of phase 3 clinical trials that were registered as completed on ClinicalTrials.gov. We searched ClinicalTrials.gov, PubMed, and Google Scholar for publications and contacted principal investigators or sponsors. The analysis was performed according to STROBE criteria. Results Considering studies that were completed before 2014 (N = 99), 75 (76%) pediatric phase 3 clinical trials were published but 24 (24%) remained unpublished. The unpublished studies concealed evidence from 4,437 patients. Mean time-to-publication was 25 SD ± 15.6 months, more than twice as long as mandated. Conclusion Ten years after the ICMJE’s clinical trials registration initiative there is still a considerable amount of selective reporting and delay of publication that potentially distorts the body of evidence in the treatment of pediatric seizures. PMID:26735955

  8. Ten years hence--has the South African choice on Termination of Pregnancy Act, Act 92 of 1996, realised its aims? A moral-critical evaluation.

    PubMed

    de Roubaix, M

    2007-03-01

    The South African Choice on Termination of Pregnancy Act (Act 92 of 1996) (CTOP) passed by parliament ten years ago, aims to promote female reproductive autonomy through legitimising free access to abortion up to 20 weeks' of gestation. The article critically evaluates CTOP and highlights three societal concerns: the effect of CTOP on the self-esteem of nurses who perform abortion; the effect on general societal morality, and its desirability. CTOP has enjoyed mixed success. On the plus side, it has furthered female reproductive autonomy, has decreased early pregnancy maternal mortality and has advanced non-racialism through equal access to safe abortion. On the minus side, it remains controversial; the majority of the population opposes abortion on request, predominantly based on religiously-informed intuitions on the value of ante-natal life. Officials and managers of public health care facilities are often obstructive, and TOP personnel victimised and socially stigmatised. An unacceptably high rate of unsafe abortion prevails, particularly in rural areas and amongst adolescents, but also in certain urban areas. The prime causes are inadequate public education, attitudinal problems, and lack of psychological support for TOP personnel, the segregation of ante-natal care and abortion services, inadequate training, research, communication and contraceptive services, absence of incentives for TOP personnel and "traditional" gender roles and male power-based domination in reproductive choices. Corrective measures include a goal directed educational programme and initiatives like value clarification workshops which have been effective in changing negative attitudes of participants, and may thus address stigmatisation, improve working conditions of TOP personnel, promote societal tolerance and acceptance, and informed consent. Of particular concern are the questions of informed consent, minors, promotion of counselling and contraceptive services (particularly for

  9. Ten-year trends of atmospheric mercury in the high Arctic compared to Canadian sub-Arctic and mid-latitude sites

    NASA Astrophysics Data System (ADS)

    Cole, A. S.; Steffen, A.; Pfaffhuber, K. A.; Berg, T.; Pilote, M.; Poissant, L.; Tordon, R.; Hung, H.

    2013-02-01

    Global emissions of mercury continue to change at the same time as the Arctic is experiencing ongoing climatic changes. Continuous monitoring of atmospheric mercury provides important information about long-term trends in the balance between transport, chemistry, and deposition of this pollutant in the Arctic atmosphere. Ten-year records of total gaseous mercury (TGM) from 2000 to 2009 were analyzed from two high Arctic sites at Alert (Nunavut, Canada) and Zeppelin Station (Svalbard, Norway); one sub-Arctic site at Kuujjuarapik (Nunavik, Québec, Canada); and three temperate Canadian sites at St. Anicet (Québec), Kejimkujik (Nova Scotia) and Egbert (Ontario). Five of the six sites examined showed a decreasing trend over this time period. Overall trend estimates at high latitude sites were: -0.9% yr-1 (95% confidence limits: -1.4, 0) at Alert and no trend (-0.5, +0.7) at Zeppelin Station. Faster decreases were observed at the remainder of the sites: -2.1% yr-1 (-3.1, -1.1) at Kuujjuarapik, -1.9% yr-1 (-2.1, -1.8) at St. Anicet, -1.6% yr-1 (-2.4, -1.0) at Kejimkujik and -2.2% yr-1 (-2.8, -1.7) at Egbert. Trends at the sub-Arctic and mid-latitude sites agree with reported decreases in background TGM concentration since 1996 at Mace Head, Ireland, and Cape Point, South Africa, but conflict with estimates showing an increase in global anthropogenic emissions over a similar period. Trends in TGM at the two high Arctic sites were not only less negative (or neutral) overall but much more variable by season. Possible reasons for differences in seasonal and overall trends at the Arctic sites compared to those at lower latitudes are discussed, as well as implications for the Arctic mercury cycle. The first calculations of multi-year trends in reactive gaseous mercury (RGM) and total particulate mercury (TPM) at Alert were also performed, indicating increases from 2002 to 2009 in both RGM and TPM in the spring when concentrations are highest.

  10. Ten-year trends of atmospheric mercury in the high Arctic compared to Canadian sub-Arctic and mid-latitude sites

    NASA Astrophysics Data System (ADS)

    Cole, A. S.; Steffen, A.; Aspmo Pfaffhuber, K.; Berg, T.; Pilote, M.; Poissant, L.; Tordon, R.; Hung, H.

    2012-08-01

    Global emissions of mercury continue to change at the same time as the Arctic is experiencing ongoing climatic changes. Continuous monitoring of atmospheric mercury provides important information about long-term trends in the balance between transport, chemistry, and deposition of this pollutant in the Arctic atmosphere. Ten-year records of total gaseous mercury (TGM) were analyzed from two high Arctic sites at Alert (Nunavut, Canada) and Zeppelin Station (Svalbard, Norway); one sub-Arctic site at Kuujjuarapik (Nunavik, Québec, Canada); and three temperate Canadian sites at St. Anicet (Québec), Kejimkujik (Nova Scotia) and Egbert (Ontario). Five of the six sites examined show a decreasing trend over this time period. Overall trend estimates at high latitude sites were: -0.9% yr-1 (95% confidence limits: -1.4, 0) at Alert and no trend (-0.5, +0.7) at Zeppelin Station. Faster decreases were observed at the remainder of the sites: -2.1% yr-1 (-3.1, -1.1) at Kuujjuarapik, -1.9% yr-1 (-2.1, -1.8) at St. Anicet, -1.6% yr-1 (-2.4, -1.0) at Kejimkujik and -2.2% yr-1 (-2.8, -1.7) at Egbert. Trends at the sub-Arctic and mid-latitude sites agree with reported decreases in background TGM concentration since 1996 at Mace Head, Ireland, and Cape Point, South Africa, but conflict with estimates showing an increase in global anthropogenic emissions over a similar period. Trends in TGM at the two high Arctic sites were not only less negative (or neutral) overall but much more variable by season. Possible reasons for differences in seasonal and overall trends at the Arctic sites compared to those at lower latitudes are discussed, as well as implications for the Arctic mercury cycle. The first calculations of multi-year trends in reactive gaseous mercury (RGM) and total particulate mercury (TPM) at Alert were also performed, indicating increases from 2002 to 2009 in both RGM and TPM in the spring when concentrations are highest.

  11. Framingham Ten-Year General Cardiovascular Disease Risk: Agreement between BMI-Based and Cholesterol-Based Estimates in a South Asian Convenience Sample

    PubMed Central

    Jones, Charlotte A.; Ross, Leanne; Surani, Nadia; Dharamshi, Narissa; Karmali, Karima

    2015-01-01

    The goal of this analysis was to determine the agreement between body mass index-based and cholesterol-based ten-year Framingham general cardiovascular disease risk scores among a convenience sample of 773 South Asian Canadian adults attending community-based screening clinics. Scores were calculated using age, systolic blood pressure, antihypertensive use, current smoking, diabetes, and total cholesterol and high density lipoprotein (for cholesterol-based risk) or height and weight (for body mass index-based risk). Mean risk score differences (body mass index-based risk minus cholesterol-based risk) were estimated using paired t-tests. Bland-Altman plots were used to assess agreement between scores. Finally, agreement across risk categories (low [<10%], moderate [10% to <20%], high [> = 20%]) was examined using the kappa statistic. Average agreement between the two risk scores was quite good overall (mean differences of 0.6% for men and 0.5% for women), but increased to about 3% among participants 60–74 years of age. However, Bland-Altman plots revealed that the differences between the two scores and the variability of the differences increased with increasing average 10-year risk. In terms of clinical importance, the limits of agreement were reasonable for women < 60 years (95% confidence interval: -3.2% to 3.1%), but of concern for women 60-74 years (95% confidence interval: -6.0% to 12.3%), men < 60 years (95% confidence interval: -7.1% to 7.3%) and men 6-074 years (95% confidence interval: -13.8% to 18.8%). Agreement across categories was moderate for most sex and age groups examined (kappa values: 0.51 for women < 60 years, 0.50 for women 60-74 years, 0.65 for men < 60 years), except for men 60-74 years, where agreement was only fair (kappa = 0.26). In light of these disagreements, evaluation of a participant’s change in cardiovascular disease risk over time will necessitate use of the same risk score (i.e., either body mass index-based or cholesterol

  12. The case study in the applicability of the improvements in the treatment of urinary system stone diseases in Anatolia: the last ten years with the sample of Western Black Sea region

    PubMed Central

    Turkan, Sadi; İrkılata, Lokman; Ekmekçioğlu, Ozan; Canat, Halil Lütfi; Dilmen, Cem; Özkaya, Muharrem

    2015-01-01

    Objective The prevalence of stone diseases is high in Turkey. Thanks to the technological improvements and to the increase in the number of qualified and experienced specialists in the last thirty years, there has been an increase in the application of minimally invasive methods in the stone disease surgery. This study, with a sample survey of Western Black Sea region, aims at revealing the changes and improvements in the treatment of stone diseases in different centers in Anatolia within the last ten years. Material and methods Six centers in 4 of the provinces of the Western Black Sea Region were selected and the patients’ files were retrospectively analyzed. The treatment methods that were recommended for and/or applied to the patients diagnosed with urinary stone diseases were recorded by years. The urinary stone diseases were divided into three separate groups; kidney, ureters and bladder. Treatment options were recorded into categories as open surgery, percutaneous nephrolithotripsy, retrograde intrarenal surgery, semirigid ureterorenoscopy, flexible ureterorenoscopy, and ESWL. Results A total of 26044 patients with stone diseases have been treated in the above-mentioned centers for the last 10 years. The distributions of the stone diseases in relation to their localization were as follows: - kidney stones: 9040 (34.7%), ureter stones: 15264 (58.6%), and bladder stones: 1740 (6.7%). As for the distribution of the treatment in relation to the treatment methods, it was seen that open surgery for 1032 (4%) patients, endoscopic surgery for 15038 (58%) patients, and ESWL for 9974 (38%) patients had been applied. While URS and PCNL are currently the commonly used treatment methods in the Western Black Sea Region, RIRS has begun to be used in a limited number of patients for the last 3 years. Conclusion Though being a little late, the advances in endrourology offer practical applications in the Western Black Sea region as well. Although this study suggests

  13. An Analysis of Trends for People with MR, Cerebral Palsy, and Epilepsy Receiving Services from State VR Agencies: Ten Years of Progress.

    ERIC Educational Resources Information Center

    Gilmore, Dana Scott; Schuster, Jennifer L.; Timmons, Jaimie Ciulla; Butterworth, John

    2000-01-01

    Presents the results of a secondary analysis of the RSA- 911 database from the Rehabilitation Services Administration. All successful vocational rehabilitation (VR) closures for individuals with mental retardation, cerebral palsy, and epilepsy for five data points between 1985 and 1995 were investigated. Trends in the use of competitive employment…

  14. Does involvement in food preparation track from adolescence to young adulthood and is it associated with better dietary quality? Findings from a ten-year longitudinal study

    PubMed Central

    Larson, Nicole I.; Neumark-Sztainer, Dianne; Story, Mary

    2012-01-01

    Objectives To examine whether involvement in food preparation tracks over time, between adolescence (15–18 years), emerging adulthood (19–23 years), and the mid-to-late twenties (24–28 years), as well as examine 10-year longitudinal associations between home food preparation, dietary quality and meal patterning. Design Population-based, longitudinal cohort study. Setting Participants were originally sampled from Minnesota public secondary schools (USA). Subjects Participants enrolled in Project EAT (Eating Among Teens)-I, EAT-II, and EAT-III (n=1,321). Results Most participants in their mid-to-late twenties reported an enjoyment of cooking (73% of males, 80% of females); however, few prepared meals including vegetables most days of the week (24% males, 41% females). Participants in their mid-to-late twenties who enjoyed cooking were more likely to have engaged in food preparation as adolescents and emerging adults (p<0.01); those who frequently prepared meals including vegetables were more likely to have engaged in food preparation as emerging adults (p<0.001), but not adolescents. Emerging adult food preparation predicted better dietary quality five years later in the mid-to-late twenties, including higher intakes of fruit, vegetables, dark green/orange vegetables, and less sugar sweetened beverage and fast food consumption. Associations between adolescent food preparation and later dietary quality yielded few significant results. Conclusions Food preparation behaviors appeared to track over time, and engagement in food preparation during emerging adulthood, but not adolescence, was associated with healthier dietary intake during the mid-to-late twenties. Intervention studies are needed to understand whether promoting healthy food preparation results in improvements in eating patterns during the transition to adulthood. PMID:22124458

  15. Ten Years and 1 Master Settlement Agreement Later: The Nature and Frequency of Alcohol and Tobacco Promotion in Televised Sports, 2000 Through 2002

    PubMed Central

    Zwarun, Lara

    2006-01-01

    Objectives. I sought to identify what kinds of promotion for alcohol and tobacco products are found in televised sports programming, as well as how frequently they occur. I compared my findings with data from 5 and 10 years earlier to examine the effects of the Master Settlement Agreement and detect industry trends. Method. A content analysis of more than 83 hours of televised sports programming from 2000 through 2002 was conducted. Composite week sampling was used to ensure results were representative of the overall population of television sports programs. Programs were examined for traditional advertising (commercials) and nontraditional advertising (stadium signs, announcer voiceovers, etc.). Results. Rates of certain types of alcohol advertising have decreased, but what remains is strategically chosen to increase the likelihood of audience exposure. Despite the Master Settlement Agreement, tobacco advertising remains prevalent in many sports. A new trend of placing alcohol and tobacco brand names in commercials for other products is evident. Conclusions. Alcohol and tobacco marketers appear able to cleverly adapt to advertising challenges, such as digital video recorders and legislation. Alcohol and tobacco brands remain visible on sports programming. PMID:16809598

  16. Antibiotic-Resistant Bacteria Are Major Threats of Otitis Media in Wollo Area, Northeastern Ethiopia: A Ten-Year Retrospective Analysis

    PubMed Central

    Argaw-Denboba, Ayele; Abejew, Asrat Agalu; Mekonnen, Alemayehu Gashaw

    2016-01-01

    Antibiotic resistance is an increasingly serious threat to human health that needs an urgent action. The aim of this study was to determine the prevalence and antibiotic susceptibility profiles of bacteria isolated from patient ear discharges suspected of otitis media. A retrospective analysis was performed using culture and antibiotic susceptibility test results of 1225 patients who visited Dessie Regional Health Research Laboratory from 2001 to 2011. Results showed a strong association (P < 0.001) between age and the risk of acquiring middle ear infection. The predominant bacterial isolates were Proteus spp. (28.8%), Staphylococcus aureus (23.7%), and Pseudomonas spp. (17.2%). Most of the isolated bacteria showed high resistance to ampicillin (88.5%), ceftriaxone (84.5%), amoxicillin (81.9%), and tetracycline (74.5%). About 72.5% of Proteus spp. and 62.2% of Pseudomonas spp. have developed resistance to one and more antibiotics used to treat them. This retrospective study also revealed the overall antibiotic resistance rate of bacterial isolates was increased nearly twofold (P = 0.001) over the last decade. Relatively, ciprofloxacin and gentamicin were the most effective antibiotics against all the isolates. In conclusion, antibiotic-resistant bacteria are alarmingly increasing in Wollo area, northeastern Ethiopia, and becoming a major public health problem in the management of patients with middle ear infection. PMID:26904125

  17. An update in varicose vein pathology after ten years of endovenous laser therapy (EVLT) with a 980 nm diode laser: clinical experience of a single center

    PubMed Central

    Scarpelli, Pietro; Maggipinto, Annamaria; Leopardi, Marco; Di Marco, Evelina; Boschetti, Michelangelo; Sbenaglia, Giorgio; Spartera, Carlo; Ventura, Marco

    2013-01-01

    Aim: To show our experience in the surgical treatment of superficial vein insufficiency of the lower limbs. Subjects and methods: Since 2002 we have performed 659 procedures of endovascular laser therapy (EVLT) (group A) in the treatment of chronic venous insufficiency of the great saphenous vein using a 980 nm diode laser. A closely matched group of 100 patients (50 Group A, 50 Group B) with homogeneous clinical findings (CEAP classification) was controlled with a mean follow-up of 18 months in our more recent experience (3 years). Most patients operated on in this period were lost to follow-up. Results: The Final results showed that EVLT can be used only in a specific selected group of cases based on anatomy and hemodynamics and while 980 nm EVLT could not be selected as the best treatment for this pathology, it could be placed side by side with conventional therapy. Conclusions: In our one year's more recent experience, we observed an increased number of patients treated with conventional therapy. The development of new laser tools (new wavelengths and continuous radial laser) and the improvement of clinical follow up may lead us to a more correct application of EVLT in the absence of randomized trials because of widespread clinical findings and poor pathological follow-up of this approach to superficial venous insufficiency. PMID:24511204

  18. Ten years of continuous observations of stratospheric ozone depleting gases at Monte Cimone (Italy)--comments on the effectiveness of the Montreal Protocol from a regional perspective.

    PubMed

    Maione, M; Giostra, U; Arduini, J; Furlani, F; Graziosi, F; Lo Vullo, E; Bonasoni, P

    2013-02-15

    Halogenated gases potentially harmful to the stratospheric ozone layer are monitored worldwide in order to assess compliance with the Montreal Protocol requiring a phase out of these compounds on a global scale. We present the results of long term (2002-2011) continuous observation conducted at the Mt. Cimone GAW Global Station located on the highest peak of the Italian Northern Apennines, at the border of two important regions: the Po Valley (and the Alps) to the North and the Mediterranean Basin to the South. Bi-hourly air samples of CFC-12, CFC-11, CFC-114, CFC-115, H-1211, H-1301, methyl chloroform, carbon tetrachloride, HCFC-22, HCFC-142b, HCFC-124 and methyl bromide are collected and analysed using a gas chromatograph-mass spectrometer, providing multi annual time series. In order to appreciate the effectiveness of the Montreal Protocol from a regional perspective, trends and annual growth rates of halogenated species have been calculated after identification of their baseline values. A comparison with results from other international observation programmes is also presented. Our data show that the peak in the atmospheric mixing ratios of four chlorofluorocarbons, two halons and two chlorocarbons has been reached and all these species now show a negative atmospheric trend. Pollution episodes are still occurring for species like halon-1211, methyl chloroform and carbon tetrachloride, indicating fresh emissions from the site domain which could be ascribed both to fugitive un-reported uses of the compounds and/or emissions from banks. For the hydrofluorocarbons changes in the baseline are affected by emissions from fast developing Countries in East Asia. Fresh emissions from the site domain are clearly declining. Methyl bromide, for which the Mediterranean area is an important source region, shows, in a generally decreasing trend, an emission pattern that is not consistent with the phase-out schedule of this compound, with a renewed increase in the last two

  19. Ten Years after the Prestige Oil Spill: Seabird Trophic Ecology as Indicator of Long-Term Effects on the Coastal Marine Ecosystem

    PubMed Central

    Moreno, Rocío; Jover, Lluís; Diez, Carmen; Sardà, Francesc; Sanpera, Carola

    2013-01-01

    Major oil spills can have long-term impacts since oil pollution does not only result in acute mortality of marine organisms, but also affects productivity levels, predator-prey dynamics, and damages habitats that support marine communities. However, despite the conservation implications of oil accidents, the monitoring and assessment of its lasting impacts still remains a difficult and daunting task. Here, we used European shags to evaluate the overall, lasting effects of the Prestige oil spill (2002) on the affected marine ecosystem. Using δ15N and Hg analysis, we trace temporal changes in feeding ecology potentially related to alterations of the food web due to the spill. Using climatic and oceanic data, we also investigate the influence of North Atlantic Oscillation (NAO) index, the sea surface temperature (SST) and the chlorophyll a (Chl a) on the observed changes. Analysis of δ15N and Hg concentrations revealed that after the Prestige oil spill, shag chicks abruptly switched their trophic level from a diet based on a high percentage of demersal-benthic fish to a higher proportion of pelagic/semi-pelagic species. There was no evidence that Chl a, SST and NAO reflected any particular changes or severity in environmental conditions for any year or season that may explain the sudden change observed in trophic level. Thus, this study highlighted an impact on the marine food web for at least three years. Our results provide the best evidence to date of the long-term consequences of the Prestige oil spill. They also show how, regardless of wider oceanographic variability, lasting impacts on predator-prey dynamics can be assessed using biochemical markers. This is particularly useful if larger scale and longer term monitoring of all trophic levels is unfeasible due to limited funding or high ecosystem complexity. PMID:24130877

  20. Ten-year Investigation of Clinical, Laboratory and Radiologic Manifestations and Complications in Patients with Takayasu’s Arteritis in Three University Hospitals

    PubMed Central

    Nooshin, Dalili; Neda, Pazhouhi; Shahdokht, Samangooyi; Ali, Jamalian

    2013-01-01

    Background: Takayasu arteritis is a condition of unknown aetiology that affects the aorta and its primary branches. The disease has been primarily recognized and described in Asia. The aims of this study were to identify the main clinical, laboratory, and angiographic features of Takayasu arteritis in Iranian patients over a 10 year period from 2000 to 2010. Methods: Data were obtained from angiographic and medical records of patients treated at Shahid-Rajai, Taleghani, and Loghman Hospitals during the above-mentioned time period. The criteria for definitions and findings were those proposed by the American College of Rheumatology. Results: A total of 15 patients were identified. The median age at presentation was 36 years and 73.3% of patients were females. Fever was the most common presentation. According to “modified” National Institute of Health criteria, 44.7% of patients were in the acute phase of disease with systemic symptoms such as fever, weight loss, and elevated C-reactive protein (CRP) levels. Immunological markers such as antinuclear antibodies (ANA) and antineutrophil cytoplasmic antibodies (C-ANCA) were absent. The tuberculin test result was positive in 40% of the patients. Vascular bruit was present in 86.7% and hypertension was detected in 53.3% with 13.3% having associated renal artery stenosis. The angiographic manifestations were classified as; type I, cervicobrachial type (26.6%); type II, thoracoabdominal type (20.0%); type III, peripheral type (6.6%); and type IV, generalised type (46.7%). Coronary arteries were involved in three cases, pulmonary in two and renal in two. Conclusion: Based on our findings, the most common clinical, laboratory and angiographic findings were fever, increased erythrocyte sedimentation rate (ESR) and stenosis, respectively. Because of dangerous consequences of this disease, attention to fever and increased ESR, especially in young women may be helpful for physicians to prevent diagnosis delay. PMID:23966824

  1. IFKIS - ten years of experience with the intercantonal early warning and crisis information system as a good-practice example for local capacity building

    NASA Astrophysics Data System (ADS)

    Bründl, M.; Stoffel, L.

    2012-04-01

    As a consequence of the avalanche winter in January/February 1999 in Switzerland the project "intercantonal early warning and crisis information system" (IFKIS) was initialised. The goal of this project was to close the gaps recognised in the event analysis of this one-month avalanche period, which caused 17 fatalities and over 600 million CHF of damage [1,2]. Whereas the system of integral avalanche protection consisting of technical measures, land use planning and protection forests proved to be successful, the most important gaps were found to be in the organisational part. Especially communities who did not have an every-winter-experience had faced problems in managing the extraordinary event. The main deficiencies were less experienced or even missing local avalanche safety services and missing information and communication. The results of the IFKIS project embrace a concept for education courses, a concept for compulsory booklets and a guideline for the daily work in local avalanche safety services, and the information system IFKIS-InfoManager improving the two-way communication between the national avalanche warning service and the local services on the one side and enhancing the communication between local and regional avalanche services (IFKIS-MIS) on the other side [3]. The results of the project IFKIS are implemented in practice since 10 years. Since 2000 every winter two to three courses were conducted at two levels either in German, French and Italian. Since 2000 about thousand participants completed the courses. Feedback from participants and observations made by cantonal authorities and the national avalanche warning centre SLF revealed that these education courses greatly improved the local capacity for dealing with critical avalanche situations. The system of regular avalanches courses at the community level served meanwhile as a good-practice example for comparable courses initialised by the Federal Office for the Environment (FOEN) as a

  2. Bronchoalveolar Lavage Fluid Characteristics of Patients With Sarcoidosis and Nonsarcoidosis Interstitial Lung Diseases: Ten-Year Experience of a Single Center in Turkey

    PubMed Central

    Tanriverdi, Hakan; Erboy, Fatma; Altinsoy, Bulent; Uygur, Firat; Arasli, Mehmet; Ozel Tekin, Ishak; Tor, Muge Meltem; Atalay, Figen

    2015-01-01

    Background: Bronchoalveolar lavage (BAL) is a noninvasive and useful technique for evaluating interstitial lung diseases (ILDs). Flow cytometric analysis of BAL fluid reveals specific diagnostic information in some unusual ILDs, and helps to narrow down the possible causes of interstitial diseases in most patients with more common disorders. A high BAL CD4/CD8 ratio is highly specific for sarcoidosis but can also be seen in other ILDs. Objectives: In this retrospective, descriptive, cross-sectional study, we compared BAL fluid characteristics and clinical variables in patients with sarcoidosis and non-sarcoidosis ILDs in a large cohort. Patients and Methods: The study was conducted in a tertiary university hospital in Zonguldak, the biggest city of the western Black Sea region of Turkey. Between 2004 and 2014, all patients who underwent both fiberoptic bronchoscopy and BAL with a suspicion of ILD were included in the study, retrospectively. Patients were divided into two main groups: sarcoidosis and non-sarcoidosis ILDs. Non-sarcoidosis ILDs were further divided into subgroups: pneumoconiosis, tuberculosis (TB), collagen vascular diseases, idiopathic interstitial pneumonias, malignancies, and unclassified ILDs. The clinical data of patients, including age, gender, smoking status, pulmonary function tests, and BAL flow cytometric analysis results, were compared among groups. Results: In total, 261 patients (119 sarcoidosis and 142 non-sarcoidosis ILDs) were enrolled. The median (interquartile range) BAL CD4/CD8 ratio and lymphocyte fraction were significantly higher in sarcoidosis than in non-sarcoidosis ILDs: 3.88 (3.76) versus 0.88 (1.01), respectively, and 20.6 (28.3) versus 6.0 (13.7), respectively. T cell receptor γ delta, CD16+56+, CD103+, CD8+103+, and CD3+16+56+ cells were significantly lower in sarcoidosis than in non-sarcoidosis ILDs. The median BAL CD4/CD8 ratios were significantly higher in patients with TB (1.87, P = 0.01) and malignancies (1.69, P = 0

  3. The Australian and New Zealand Haemostasis Registry: ten years of data on off-licence use of recombinant activated factor VII

    PubMed Central

    Zatta, Amanda; McQuilten, Zoe; Kandane-Rathnayake, Rangi; Isbister, James; Dunkley, Scott; McNeil, John; Cameron, Peter; Phillips, Louise

    2015-01-01

    Background Recombinant activated factor VII (rFVIIa) has been widely used as an off-licence pan-haemostatic agent in patients with critical bleeding. However, outside the trauma setting, there is relatively little high quality evidence on the risks and benefits of this agent. The Haemostasis Registry was established to investigate the extent of use, dosing, safety and outcomes of patients after off-licence rFVIIa treatment of critical bleeding. Materials and methods The Registry recruited non-haemophiliac patients treated with rFVIIa from 2000–2009 (inclusive) in Australia and New Zealand. Detailed information was gathered on patients’ demographics, context of bleeding, rFVIIa administration, laboratory results, blood component and other therapies, and outcomes. Outcome measures included subjectively assessed effect of rFVIIa on bleeding (response), adverse events (thromboembolic and other) and 28-day mortality. Results The registry included 3,446 cases in 3,322 patients (median [IQR] age 56 [33–70] years, 65% (n=2,147) male). Clinical indications included cardiac surgery (45%), other surgery (18%), trauma (13%), medical bleeding (6%), liver disease (6%), and obstetric haemorrhage (5%). The median [IQR] dose was 91 [72–103] μg/kg and 77% received a single dose. Reduction or cessation of bleeding was reported in 74% and 28-day survival was 71% but outcomes varied depending on clinical context. pH strongly correlated with outcome measures; 81% of patients with pH <7.1 died. Approximately 11% of patients had thromboembolic adverse events. In multivariate analysis, pH prior to administration and bleeding context were independently associated with reported response to rFVIIa and 28-day mortality. Discussion The Haemostasis Registry is the largest dataset of its kind and provides observational data on the off-licence use of rFVIIa over a 10-year period. It has been an invaluable resource for rigorously tracking adverse events and helping to inform clinical

  4. Wuchereria bancrofti infection in human and mosquito populations of a Polynesian village ten years after interruption of mass chemoprophylaxis with diethylcarbamazine.

    PubMed

    Cartel, J L; Nguyen, N L; Spiegel, A; Moulia-Pelat, J P; Plichart, R; Martin, P M; Manuellan, A B; Lardeux, F

    1992-01-01

    In 1991, a study on Wuchereria bancrofti microfilariae (mf) and infection rates was carried out in the human and mosquito populations of a Polynesian village where, 10 years before, the mf prevalence rate was 6.4% and twice-yearly mass treatment with 3 mg/kg of diethylcarbamazine (DEC) was interrupted. Venous blood samples were collected from 575 (97%) individuals aged 15 years or more, of whom 122 (21.4%) were mf positive. The mf carrier prevalence rate was 27.4% in males, significantly higher than that of 14% in females; it increased from 7-12% in the youngest age group (15-19 years) to 40-50% in the oldest (> or = 60 years) for both males and females. 387 mosquito collections were performed and 1748 female Aedes polynesiensis were dissected, of which 1176 were parous. Among the latter, 114 (9.7%) were infected with Wuchereria bancrofti larvae at L1, L2 or L3 stages. The mean number of larvae per mosquito was 2.46 (range 1-15). Of the 114 infected mosquitoes, 30 harboured L3 larvae, giving a 2.55% infective rate; the mean number of L3 larvae per mosquito was 1.15 (range 1-2). Such findings indicate that the interruption of systematic twice-yearly mass treatment with DEC (3 mg/kg) has resulted, after 10 years, in a substantial increase of microfilarial prevalence in humans, and in high infection rates in mosquitoes. PMID:1440820

  5. Congenital Kyphoscoliosis in Monozygotic Twins: Ten-Year Follow-up Treated by Posterior Vertebral Column Resection (PVCR): A Case Report.

    PubMed

    Chang, Dong-Gune; Yang, Jae Hyuk; Lee, Jung-Hee; Kim, Young-Hoon; Kim, Jin-Hyok; Suh, Seung-Woo; Ha, Kee-Yong; Suk, Se-Il

    2016-04-01

    The etiology of congenital scoliosis and its development remains unclear and has not yet been fully identified, even there are theories that congenital scoliosis could be derived from the failure of formation or failure of segmentation, which are etiologically heterogeneous with genetic, epigenetic, and environmental factors contributing to their occurrence. We reported a case of long-term follow-up after posterior vertebral column resection (PVCR) in both identical twins with similar congenital kyphoscoliosis at thoracolumbar levels. Twin I had been noticed by his parents to have asymmetry of his back at age 5 years, but no treatment was given. Twin II was first noticed to have a spinal problem at 11 years of age by his parents. Overtime, spine of both twins became further deviated to the left with kyphosis and was referred to our hospital. Both monozygotic twins were treated by PVCR and satisfactory results were demonstrated at 10-year follow-up.This case is the first report on the surgical treatment with PVCR, almost simultaneously, in both identical twins who had similar congenital vertebral anomalies causing kyphoscoliosis. Both identical twins with congenital kyphoscoliosis had undergone surgical correction by PVCR, anterior support with a mesh cage and posterior fusion using pedicle screws at the age of 14 years and achieved a satisfactory correction and a stable spine without curve progression with 10-year follow-up. PMID:27124052

  6. A Ten Year Retrospective Study on Adult Tetanus at the Epidemic Disease (ED) Hospital, Mysore in Southern India: A Review of 512 Cases

    PubMed Central

    Marulappa, Vamadeva Giriyapura; Manjunath, Renuka; Mahesh Babu, Nakul; Maligegowda, Laxman

    2012-01-01

    Background Tetanus still remains a major public health problem in India like in most other developing countries, with a high morbidity and mortality. Objectives To study the socio-demographic profile and the clinical profile that they presented with, as well as the outcome of the tetanus patients who were admitted to the E.D Hospital, Mysore in India. Methodology The data of all the patients of tetanus who were above the age of 15 years, who were admitted from January 2001 to December 2010, were collected, compiled and analyzed from the Medical Records Department of the Hospital. Results Out of the 512 cases of tetanus, 379 (74%) were males and 133 (26%) were females. Their ages varied from 15 to 81 years, with a mean and a standard deviation respectively of 47.7 and 15.0 years. The overall mortality rate was 42.2%. The most common presenting symptoms were trismus (95.7%), neck stiffness (89.3%), body spasms/stiffness (73%) and dysphagia (38.9%). The ages of the patients and the presence of complications had a statistically significant relationship with respect to the outcome (survival versus death). PMID:23205351

  7. Environmental noise exposure, early biological risk and mental health in nine to ten year old children: a cross-sectional field study

    PubMed Central

    2011-01-01

    Background Previous research suggests that children born prematurely or with a low birth weight are more vulnerable to the mental health effects of ambient neighbourhood noise; predominantly road and rail noise, at home. This study used data from the Road Traffic and Aircraft Noise Exposure and Children's Cognition and Health (RANCH) study to see if this finding extends to aircraft and road traffic noise at school. Methods Children and their parents from schools around three European airports were selected to represent a range of aircraft and road traffic noise exposure levels. Birth weight and gestation period were merged to create a dichotomous variable assessing 'early biological risk'. Mental health was assessed using the Strengths and Difficulties Questionnaire (SDQ). Complete data were available for 1900 primary school children. Results Children who were 'at risk' (i.e. low birth weight or premature birth) were rated as having more conduct problems and emotional symptoms and poorer overall mental health than children not at risk. However, there was no interaction between aircraft or road traffic noise exposure at school and early biological risk. Conclusions Data from the RANCH study suggests that children with early biological risk are not more vulnerable to the effects of aircraft or road traffic noise at school on mental health than children without this risk; however they are more likely to have mental ill-health. PMID:21569605

  8. Change in Antimicrobial Susceptibility of Skin-Colonizing Staphylococcus aureus in Korean Patients with Atopic Dermatitis during Ten-Year Period

    PubMed Central

    Park, Jung-Min; Jo, Ju-Hyun; Jin, Hyunju; Ko, Hyun-Chang; Kim, Moon-Bum; Kim, Jung-Min; Kim, Do-Won; Jang, Ho-Sun

    2016-01-01

    Background A small subset of adolescents atopic dermatitis (AD) tends to persist. This also leads to get more antibiotics exposure with advancing years. Antibiotic resistance has been regarded as a serious problem during Staphylococcus aureus treatment, especially methicillin-resistant S. aureus (MRSA). Objective It was investigated the S. aureus colonization frequency in the skin lesions and anterior nares of adolescent AD patients and evaluated the changes in S. aureus antimicrobial susceptibility for years. Methods Patients who visited our clinic from September 2003 to August 2005 were classified into group A, and patients who visited from August 2010 to March 2012 were classified into group B. To investigate the differences with regard to patients' age and disease duration, the patients were subdivided into groups according to age. Lesional and nasal specimens were examined. Results Among the 295 AD patients, the total S. aureus colonization rate in skin lesions was 66.9% (95/142) for group A and 78.4% (120/153) for group B. No significant changes in the systemic antimicrobial susceptibilities of S. aureus strains isolated from adolescent AD patients were observed during about 10-year period. The increased trend of MRSA isolation in recent adolescent AD outpatients suggest that the community including school could be the source of S. aureus antibiotic resistance and higher fusidic acid resistance rates provides evidence of imprudent topical use. Conclusion Relatively high MRSA isolation and fusidic acid resistance rates in recent AD patients suggest that the community harbors antibiotic-resistant S. aureus. PMID:27489430

  9. Ten-Year Trends in the Morbidity of Diabetes Mellitus and Antidiabetic Drug Utilization in Croatia: A Study Based on Routinely Collected Data

    PubMed Central

    Topličan, Ivančica; Vrcić Keglević, Mladenka

    2016-01-01

    Objectives. To investigate trends of diabetes mellitus (DM) morbidity and antidiabetic drug utilization in Croatian primary health care (PHC) from 2005 to 2014. Method. Routinely collected morbidity data from all PHC units, presented in Croatian health-statistics yearbooks, were retrieved. Data on drug utilization were retrieved from the Annual Reports of the Croatian Agency for Medicinal Products and Medical Devices (ATC/DDD, antidiabetic, A10). Results. Total morbidity increased by 33.3% and DM increased by 65.6%, mostly in patients over age 65 (from 50% to 57%). Estimated DM prevalence in adults increased from 3.9% to 6.4%. Increased morbidity was followed by an even higher increase in drug utilization (120%). Metformin was first, with a constant increase (from 18% to 39%), followed by glimepiride, while glibenclamide use decreased. Total utilization of insulin increased even more, mostly for aspart (600%) and newly introduced glargine and detemir, while human insulin usage sharply decreased. Spending also increased, mostly for aspart (from 21% to 61% of total). Conclusions. Increased DM is followed by a higher increase in antidiabetic drug utilization; this trend will continue in the future. In Croatian PHC, metformin has primacy along with insulin analogues. PMID:27462470

  10. Chelonid herpesvirus 5 in secretions and tumor tissues from green turtles (Chelonia mydas) from Southeastern Brazil: A ten-year study.

    PubMed

    Monezi, Telma A; Mehnert, Dolores U; de Moura, Elisabeth M M; Müller, Natascha M G; Garrafa, Patrícia; Matushima, Eliana R; Werneck, Max R; Borella, Maria I

    2016-04-15

    Fibropapillomatosis (FP), a neoplastic disease characterized by the formation of multiple tumors affecting different species of sea turtles and, most often, the green turtle (Chelonia mydas), is considered one of the major threats to the survival of this species. Recent studies indicate that Chelonid herpesvirus (ChHV5) is the etiological agent of this disease, though its association with anthropogenically altered environments and the immune status of these animals also appears to contribute to disease expression and tumor formation. In this study, tumor biopsy and secretions from green turtles captured off the coast of São Paulo State, Brazil, were used in histological and molecular analyses to detect and characterize circulating ChHV5. In 40.9% of cases, the tumor histopathological findings revealed focal ballooning degeneration with intranuclear inclusion bodies, results which are suggestive of viral infection. ChHV5 was detected using polymerase chain reaction (PCR) on the animals' skin, ocular tumor biopsies, and ocular and oral secretions. The analysis of the detected ChHV5 sequences revealed two distinct genetic sequences together. Phylogenetic analysis indicated that Brazilian samples were similar to ChHV5 samples described for the Atlantic phylogeographic group and are therefore part of the same clade as the Gulf of Guinea and Puerto Rico samples. This similarity suggests a possible flow of the virus between these three regions. PMID:27016769

  11. Ten-Year Trends in the Morbidity of Diabetes Mellitus and Antidiabetic Drug Utilization in Croatia: A Study Based on Routinely Collected Data.

    PubMed

    Pavlov, Renata; Topličan, Ivančica; Vrcić Keglević, Mladenka

    2016-01-01

    Objectives. To investigate trends of diabetes mellitus (DM) morbidity and antidiabetic drug utilization in Croatian primary health care (PHC) from 2005 to 2014. Method. Routinely collected morbidity data from all PHC units, presented in Croatian health-statistics yearbooks, were retrieved. Data on drug utilization were retrieved from the Annual Reports of the Croatian Agency for Medicinal Products and Medical Devices (ATC/DDD, antidiabetic, A10). Results. Total morbidity increased by 33.3% and DM increased by 65.6%, mostly in patients over age 65 (from 50% to 57%). Estimated DM prevalence in adults increased from 3.9% to 6.4%. Increased morbidity was followed by an even higher increase in drug utilization (120%). Metformin was first, with a constant increase (from 18% to 39%), followed by glimepiride, while glibenclamide use decreased. Total utilization of insulin increased even more, mostly for aspart (600%) and newly introduced glargine and detemir, while human insulin usage sharply decreased. Spending also increased, mostly for aspart (from 21% to 61% of total). Conclusions. Increased DM is followed by a higher increase in antidiabetic drug utilization; this trend will continue in the future. In Croatian PHC, metformin has primacy along with insulin analogues. PMID:27462470

  12. To be seen, confirmed and involved - a ten year follow-up of perceived health and cardiovascular risk factors in a Swedish community intervention programme

    PubMed Central

    Emmelin, Maria; Weinehall, Lars; Stenlund, Hans; Wall, Stig; Dahlgren, Lars

    2007-01-01

    Background Public health interventions are directed towards social systems and it is difficult to foresee all consequences. While targeted outcomes may be positively influenced, interventions may at worst be counterproductive. To include self-reported health in an evaluation is one way of addressing possible side-effects. This study is based on a 10 year follow-up of a cardiovascular community intervention programme in northern Sweden. Methods Both quantitative and qualitative approaches were used to address the interaction between changes in self-rated health and risk factor load. Qualitative interviews contributed to an analysis of how the outcome was influenced by health related norms and attitudes. Results Most people maintained a low risk factor load and a positive perception of health. However, more people improved than deteriorated their situation regarding both perceived health and risk factor load. "Ideal types" of attitude sets towards the programme, generated from the interviews, helped to interpret an observed polarisation for men and the lower educated. Conclusion Our observation of a socially and gender differentiated intervention effect suggests a need to test new intervention strategies. Future community interventions may benefit from targeting more directly those who in combination with high risk factor load perceive their health as bad and to make all participants feel seen, confirmed and involved. PMID:17672911

  13. Ten-years of bariatric surgery in Brazil: in-hospital mortality rates for patients assisted by universal health system or a health maintenance organization

    PubMed Central

    KELLES, Silvana Márcia Bruschi; MACHADO, Carla Jorge; BARRETO, Sandhi Maria

    2014-01-01

    Background Bariatric surgery is an option for sustained weight loss for the morbidly obese patient. In Brazil coexists the Unified Health System (SUS) with universal coverage and from which depend 150 million Brazilians and supplemental health security, predominantly private, with 50 million beneficiaries. Aim To compare access, in-hospital mortality, length of stay and costs for patients undergoing bariatric surgery, assisted in one or another system. Methods Data from DATASUS and IBGE were used for SUS patients' and database from one health plan of southeastern Brazil for the health insurance patients. Results Between 2001 and 2010 there were 24,342 and 4,356 surgeries performed in SUS and in the health insurance company, respectively. The coverage rates for surgeries performed in 2010 were 5.3 and 91/100.000 individuals in SUS and health insurance respectively. The rate of in-hospital mortality in SUS, considering the entire country, was 0.55 %, 0.44 % considering SUS Southeast, and 0.30 % for the health insurance. The costs of surgery in the SUS and in the health insurance trend to equalization over the years. Conclusion Despite differences in access and characteristics that may compromise the outcome of bariatric surgery, patients treated at the Southeast SUS had similar rate of in-hospital mortality compared to the health insurance patients. PMID:25626935

  14. Ten-year incidence of elevated blood pressure and its predictors: the CARDIA study. Coronary Artery Risk Development in (Young) Adults.

    PubMed

    Dyer, A R; Liu, K; Walsh, M; Kiefe, C; Jacobs, D R; Bild, D E

    1999-01-01

    Few prospective studies have examined associations of lifestyle factors or variables in the insulin resistance syndrome (syndrome X) with incidence of elevated blood pressure (BP) in black subjects and women. This report estimates the 10-year incidence of high blood pressure (HBP) and high normal blood pressure (HNBP) in the biracial cohort of the Coronary Artery Risk Development in (Young) Adults Study (CARDIA), and examines lifestyle factors and four syndrome X variables, measured at baseline, as predictors. CARDIA examined 5115 black and white men and women aged 18-30 years in 1985-1986, and re-examined them at 2, 5, 7, and 10 years. The 10-year incidence of HBP was 16.4% in black men, 7.8% in white men, 13.1% in black women, and 3.2% in white women, while the 10-year incidence of HBP or HNBP was 29.5%, 16.2%, 19.2%, and 6.3%, respectively, in the four sex-race subgroups. Predictors included body mass index, waist circumference, physical activity, alcohol intake, pulse rate, cigarette smoking, education, fasting insulin, triglycerides, uric acid, and high-density lipoprotein cholesterol, as well as age and systolic BP. In univariate analyses, each of these variables was significantly related to incidence in at least one of the four sex-race groups. In multivariate analyses that included control for age and systolic pressure, independent predictors included fasting insulin in white men and women, triglycerides in white men, uric acid and pulse rate in black men, waist circumference in white men and black women, and education (inverse) in white men and black and white women. These results suggest that lower socioeconomic status, as assessed by education level, and one or more syndrome X variables, ie, fasting insulin, triglycerides, uric acid, may be associated with development of elevated BP in young adults. PMID:9928747

  15. Why Is Seed Production So Variable among Individuals? A Ten-Year Study with Oaks Reveals the Importance of Soil Environment

    PubMed Central

    Pérez-Ramos, Ignacio M.; Aponte, Cristina; García, Luis V.; Padilla-Díaz, Carmen M.; Marañón, Teodoro

    2014-01-01

    Mast-seeding species exhibit not only a large inter-annual variability in seed production but also considerable variability among individuals within the same year. However, very little is known about the causes and consequences for population dynamics of this potentially large between-individual variability. Here, we quantified seed production over ten consecutive years in two Mediterranean oak species – the deciduous Quercus canariensis and the evergreen Q. suber - that coexist in forests of southern Spain. First, we calibrated likelihood models to identify which abiotic and biotic variables best explain the magnitude (hereafter seed productivity) and temporal variation of seed production at the individual level (hereafter CVi), and infer whether reproductive effort results from the available soil resources for the plant or is primarily determined by selectively favoured strategies. Second, we explored the contribution of between-individual variability in seed production as a potential mechanism of satiation for predispersal seed predators. We found that Q. canariensis trees inhabiting moister and more fertile soils were more productive than those growing in more resource-limited sites. Regarding temporal variation, individuals of the two studied oak species inhabiting these resource-rich environments also exhibited larger values of CVi. Interestingly, we detected a satiating effect on granivorous insects at the tree level in Q. suber, which was evident in those years where between-individual variability in acorn production was higher. These findings suggest that individual seed production (both in terms of seed productivity and inter-annual variability) is strongly dependent on soil resource heterogeneity (at least for one of the two studied oak species) with potential repercussions for recruitment and population dynamics. However, other external factors (such as soil heterogeneity in pathogen abundance) or certain inherent characteristics of the tree might be

  16. Alterations in bottom sediment physical and chemical characteristics at the Terra Nova offshore oil development over ten years of drilling on the grand banks of Newfoundland, Canada

    NASA Astrophysics Data System (ADS)

    DeBlois, Elisabeth M.; Paine, Michael D.; Kilgour, Bruce W.; Tracy, Ellen; Crowley, Roger D.; Williams, Urban P.; Janes, G. Gregory

    2014-12-01

    This paper describes sediment composition at the Terra Nova offshore oil development. The Terra Nova Field is located on the Grand Banks approximately 350 km southeast of Newfoundland, Canada, at an approximate water depth of 100 m. Surface sediment samples (upper 3 cm) were collected for chemical and particle size analyses at the site pre-development (1997) and in 2000-2002, 2004, 2006, 2008 and 2010. Approximately 50 stations have been sampled in each program year, with stations extending from less than 1 km to a maximum of 20 km from source (drill centres) along five gradients, extending to the southeast, southwest, northeast, northwest and east of Terra Nova. Results show that Terra Nova sediments were contaminated with >C10-C21 hydrocarbons and barium-the two main constituents of synthetic-based drilling muds used at the site. Highest levels of contamination occurred within 1 to 2 km from source, consistent with predictions from drill cuttings dispersion modelling. The strength of distance gradients for >C10-C21 hydrocarbons and barium, and overall levels, generally increased as drilling progressed but decreased from 2006 to 2010, coincident with a reduction in drilling. As seen at other offshore oil development sites, metals other than barium, sulphur and sulphide levels were elevated and sediment fines content was higher in the immediate vicinity (less than 0.5 km) of drill centres in some sampling years; but there was no strong evidence of project-related alterations of these variables. Overall, sediment contamination at Terra Nova was spatially limited and only the two major constituents of synthetic-based drilling muds used at the site, >C10-C21 hydrocarbons and barium, showed clear evidence of project-related alternations.

  17. Ten-year study of fine aerosol at Sde Boker, Israel, using PIXE: Time trends, seasonal variation, correlations, and source areas for anthropogenic elements

    NASA Astrophysics Data System (ADS)

    Maenhaut, Willy; Karnieli, Arnon; Andreae, Meinrat O.

    2014-01-01

    From January 1995 through December 2004 aerosol samples were collected at Sde Boker, Israel, with a Gent stacked filter unit sampler. The collections were done according to a 2-2-3 day schedule, which resulted in about 150 samples per year. The samples were analysed for the particulate mass (PM) by weighing, for black carbon (BC) by a light reflectance technique, and for up to 46 elements by a combination of PIXE and instrumental neutron activation analysis. Here, we report on the fine (PM2) size fraction data for the PM, BC, and the following nine anthropogenic elements S, V, Ni, Cu, Zn, As, Se, Sb, and Pb, and discuss their time trends, seasonal variation, correlations, and source areas. The largest changes in the annual medians over the 10-year period were found for S, Ni, Se, Sb, and Pb, i.e., of -34%, -25%, -47%, +26%, and -40%, respectively. The seasonal variation was largest for S, with 1.6 times higher concentrations in summer than in the other three seasons. Vanadium and Ni were very highly correlated with each other (r = 0.95), pointing to a dominant common source, which is undoubtedly oil burning. Trajectory statistics, using 10-day back trajectories with arrival at 300 m above ground, were applied to assess the source areas. Sulphur originated mostly from south-eastern Europe (i.e., Turkey, Bulgaria, Romania, Ukraine, and southern Russia) and As from the south-eastern part of European Russia, whilst the source picture for Zn was rather unclear. The other six anthropogenic elements and BC seemed to originate mainly from regional sources.

  18. Ten years of global burned area products from spaceborne remote sensing-A review: Analysis of user needs and recommendations for future developments

    NASA Astrophysics Data System (ADS)

    Mouillot, Florent; Schultz, Martin G.; Yue, Chao; Cadule, Patricia; Tansey, Kevin; Ciais, Philippe; Chuvieco, Emilio

    2014-02-01

    Early global estimates of carbon emissions from biomass burning were based on empirical assumptions of fire return interval in different biomes in the 1980s. Since then, significant improvements of spaceborne remote sensing sensors have resulted in an increasing number of derived products characterizing the detection of active fire or the subsequent burned area (GFED, MODIS MCD45A1, L3JRC, Globcarbon, GBS, GLOBSCAR, GBA2000). When coupled with global land cover and vegetation models allowing for spatially explicit fuel biomass estimates, the use of these products helps to yield important information about the spatial and the temporal variability of emission estimates. The availability of multi-year products (>10 years) leads to a better understanding of uncertainties in addition to increasing accuracy. We surveyed a wide range of users of global fire data products whilst also undertaking a review of the latest scientific literature. Two user groups were identified, the first being global climate and vegetation modellers and the second being regional land managers. Based on this review, we present here the current needs covering the range of end-users. We identified the increasing use of BA products since the year 2000 with an increasing use of MODIS as a reference dataset. Scientific topics using these BA products have increased in diversity and area of application, from global fire emissions (for which BA products were initially developed) to regional studies with increasing use for ecosystem management planning. There is a significant need from the atmospheric science community for low spatial resolution (gridded, 1/2 degree cell) and long time series data characterized with supplementary information concerning the accuracy in timing of the fire and reductions of omission/commission errors. There is also a strong need for precisely characterizing the perimeter and contour of the fire scar for better assimilation with land cover maps and fire intensity. Computer

  19. A population-based registry as a source of health indicators for rare diseases: the ten-year experience of the Veneto Region’s rare diseases registry

    PubMed Central

    2014-01-01

    Background Although rare diseases have become a major public health issue, there is a paucity of population-based data on rare diseases. The aim of this epidemiological study was to provide descriptive figures referring to a sizable group of unrelated rare diseases. Methods Data from the rare diseases registry established in the Veneto Region of north-east Italy (population 4,900,000), referring to the years from 2002 to 2012, were analyzed. The registry is based on a web-based system accessed by different users. Cases are enrolled by two different sources: clinicians working at Centers of expertise officially designated to diagnose and care patients with rare diseases and health professionals working in the local health districts. Deaths of patients are monitored by Death Registry. Results So far, 19,547 patients with rare diseases have been registered, and 23% of them are pediatric cases. The overall raw prevalence of the rare diseases monitored in the population under study is 33.09 per 10,000 inhabitants (95% CI 32.56-33.62), whilst the overall incidence is 3.85 per 10,000 inhabitants (95% CI 3.67-4.03). The most commonly-recorded diagnoses belong to the following nosological groups: congenital malformations (Prevalence: 5.45/10,000), hematological diseases (4.83/10,000), ocular disorders (4.47/10,000), diseases of the nervous system (3.51/10,000), and metabolic disorders (2,95/10,000). Most of the deaths in the study population occur among pediatric patients with congenital malformations, and among adult cases with neurological diseases. Rare diseases of the central nervous system carry the highest fatality rate (71.36/1,000). Rare diseases explain 4.2% of general population Years of Life Lost (YLLs), comparing to 1.2% attributable to infectious diseases and 2.6% to diabetes mellitus. Conclusions Our estimates of the burden of rare diseases at population level confirm that these conditions are a relevant public health issue. Our snapshot of their epidemiology

  20. Is the use of cholesterol in mortality risk algorithms in clinical guidelines valid? Ten years prospective data from the Norwegian HUNT 2 study

    PubMed Central

    Petursson, Halfdan; Sigurdsson, Johann A; Bengtsson, Calle; Nilsen, Tom I L; Getz, Linn

    2012-01-01

    Rationale, aims and objectives Many clinical guidelines for cardiovascular disease (CVD) prevention contain risk estimation charts/calculators. These have shown a tendency to overestimate risk, which indicates that there might be theoretical flaws in the algorithms. Total cholesterol is a frequently used variable in the risk estimates. Some studies indicate that the predictive properties of cholesterol might not be as straightforward as widely assumed. Our aim was to document the strength and validity of total cholesterol as a risk factor for mortality in a well-defined, general Norwegian population without known CVD at baseline. Methods We assessed the association of total serum cholesterol with total mortality, as well as mortality from CVD and ischaemic heart disease (IHD), using Cox proportional hazard models. The study population comprises 52 087 Norwegians, aged 20–74, who participated in the Nord-Trøndelag Health Study (HUNT 2, 1995–1997) and were followed-up on cause-specific mortality for 10 years (510 297 person-years in total). Results Among women, cholesterol had an inverse association with all-cause mortality [hazard ratio (HR): 0.94; 95% confidence interval (CI): 0.89–0.99 per 1.0 mmol L−1 increase] as well as CVD mortality (HR: 0.97; 95% CI: 0.88–1.07). The association with IHD mortality (HR: 1.07; 95% CI: 0.92–1.24) was not linear but seemed to follow a ‘U-shaped’ curve, with the highest mortality <5.0 and ≥7.0 mmol L−1. Among men, the association of cholesterol with mortality from CVD (HR: 1.06; 95% CI: 0.98–1.15) and in total (HR: 0.98; 95% CI: 0.93–1.03) followed a ‘U-shaped’ pattern. Conclusion Our study provides an updated epidemiological indication of possible errors in the CVD risk algorithms of many clinical guidelines. If our findings are generalizable, clinical and public health recommendations regarding the ‘dangers’ of cholesterol should be revised. This is especially true for women, for whom moderately

  1. Presence of nitrous oxide hotspots in the coastal upwelling area off central Chile: an analysis of temporal variability based on ten years of a biogeochemical time series

    NASA Astrophysics Data System (ADS)

    Farías, L.; Besoain, V.; García-Loyola, S.

    2015-04-01

    Seasonal and inter-annual variabilities of biogeochemical variables, including nitrous oxide (N2O), an important climate active gas, were analyzed during monthly observations between 2002 and 2012 at an ocean Time-Series station in the coastal upwelling area off central Chile (36° 30.8‧ 73° 15‧). Oxygen, N2O, nutrients and chlorophyll-a (Chl-a) showed clear seasonal variability associated with upwelling favorable winds (spring-summer) and also inter-annual variability, which in the case of N2O was clearly observed during the occurrence of N2O hotspots with saturation levels of up to 4849%. These hotspots consistently took place during the upwelling-favorable periods in 2004, 2006, 2008, 2010 and 2011, below the mixed layer (15-50 m depth) in waters with hypoxia and some N{{O}2}- accumulation. The N2O hotspots displayed excesses of N2O (ΔN2O) three times higher than the average monthly anomalies (2002-2012). Estimated relationships of ΔN2O versus apparent oxygen utilization (AOU), and ΔN2O versus N{{O}3}-, suggest that aerobic ammonium oxidation (AAO) and partial denitrification are the processes responsible for high N2O accumulation in subsurface water. Chl-a levels were reasonably correlated with the presence of the N2O hotspots, suggesting that microbial activities fuelled by high availability of organic matters lead to high N2O production. As a result, this causes a substantial N2O efflux into the atmosphere of up to 260 μmol m-2 d-1. The N2O hotspots are transient events or hot moments, which may occur more frequently than they are observed. If so, this upwelling area is producing and emitting greater than expected amounts of N2O and is therefore an important N2O source that should be considered in the global atmospheric N2O balance.

  2. Family time, parental behaviour model and the initiation of smoking and alcohol use by ten-year-old children: an epidemiological study in Kaunas, Lithuania

    PubMed Central

    Garmienė, Asta; Žemaitienė, Nida; Zaborskis, Apolinaras

    2006-01-01

    Background Family is considered to be the first and the most important child development and socialization bond. Nevertheless, parental behaviour model importance for the children, as well as family time for shared activity amount influence upon the child's health-related behaviour habit development has not been yet thoroughly examined. The aim of this paper is to indicate the advanced health-hazardous behaviour modelling possibilities in the families, as well as time spent for joint family activities, and to examine the importance of time spent for joint family activities for the smoking and alcohol use habit initiation among children. Methods This research was carried out in Kaunas, Lithuania, during the school year 2004–2005. The research population consisted of 369 fifth-grade schoolchildren (211 (57.2%) boys and 158 (42.8%) girls) and 565 parents: 323 (57.2%) mothers and 242 (48.2%) fathers. The response rate was 80.7% for children; 96.1% and 90.6% for mothers and fathers correspondingly. Results Eating a meal together was the most frequent joint family activity, whereas visiting friends or relatives together, going for a walk, or playing sports were the most infrequent joint family activities. More than two thirds (81.5%) of parents (248 (77.0%) mothers and 207 (85.9%) fathers (p < 0.05)) reported frequenting alcohol furnished parties at least once a month. About half of the surveyed fathers (50.6%) together with one fifth of the mothers (19.9%) (p < 0.001) were smokers. More frequently than girls, boys reported having tried smoking (6.6% and 23.0% respectively; p < 0.001) as well as alcohol (31.16% and 40.1% respectively; p < 0.05). Child alcohol use was associated both with paternal alcohol use, and with the time, spent in joint family activities. For instance, boys were more prone to try alcohol, if their fathers frequented alcohol furnished parties, whereas girls were more prone to try alcohol, if family members spent less time together. Conclusion

  3. Seasonal and inter-annual eutrophication dynamics in a hypereutrophic shallow coastal lagoon from ten years of satellite observations and in-situ data

    NASA Astrophysics Data System (ADS)

    Pitarch, Jaime; Ruiz-Verdú, Antonio; Soria, Juan M.; Santoleri, Rosalia

    2016-04-01

    The Albufera de Valencia (39.33 N, 0.37 W) is a hypereutrophic shallow coastal lagoon, having a near round shape of ~ 5 km diameter and ~ 1 m average depth. At the west side, the lake is separated from the sea by a narrow land strip, but three artificial channels allow connection to the sea, regulated by gates. The rest of the lake is surrounded by rice fields that were made by gaining surface from the lake around a century ago. Nowadays, the ecological state of the lake is very degraded. Freshwater inflow is insufficient and residence time is too high. Despite some improvements in waste water treatment, high loads of sediment-stored nutrients are often resuspended due to habitual strong winds and made available for primary production. The previously abundant bottom vegetation disappeared decades ago and secchi depth does not reach more than few tens of centimeters. The lake suffers from cyanobacterial blooms and massive fish deaths. Despite its vital importance as a coastal wetland in the western Mediterranean region, its water quality is not routinely monitored, so its seasonality and eventual blooming events have not been sistematically studied. In this study, we aim at filling this gap using satellite data. Medium-resolution satellite-borne sensors constitute an appropriate tool for this sake due to the lake's medium size and little cloud cover time over the region. In particular, the European MERIS sensor (2002-2012) is specially well suited due to its unique spectral bands configuration for cyanobacterial detection. Apart from the utility of the results themselves, study of this sensor provides a strong baseline for operational utilization of its successor, the new-coming European Sentinel 3-OLCI sensor. We have processed the full archived MERIS archived data. By adequate choice of band ratios and posterior calibration to in-situ samples, the time series of chlorophyll concentration is derived. Derived seasonality reveals a pattern that is determined by the

  4. Ten-Year Outcomes: The Clinical Utility of Single Photon Emission Computed Tomography/Computed Tomography Capromab Pendetide (Prostascint) in a Cohort Diagnosed With Localized Prostate Cancer

    SciTech Connect

    Ellis, Rodney J.; Kaminsky, Deborah A.; Zhou, Esther H.; Fu, Pingfu; Chen, Wei-Dong; Faulhaber, Peter F.; Bodner, Donald

    2011-09-01

    Purpose: To evaluate the clinical utility of capromab pendetide imaging with single photon emission computed tomography coregistration with computed tomography (SPECT/CT) in primary prostate cancer (CaP) for pretreatment prognostic staging and localization of biologic target volumes (BTV) for individualized image-guided radiotherapy dose escalation (IGRT-DE). Methods and Materials: Patients consecutively presenting for primary radiotherapy (February 1997 to December 2002), having a clinical diagnosis of localized CaP, were evaluated for tumor stage using conventional staging and SPECT/CT (N = 239). Distant metastatic uptake (mets) were identified by SPECT/CT in 22 (9.2%). None of the suspected mets could be clinically confirmed. Thus, all subjects were followed without alteration in disease management. The SPECT/CT pelvic images defined BTV for IGRT-DE (+150% brachytherapy dose) without (n = 150) or with (n = 89) external radiation of 45 Gy. The National Comprehensive Cancer Network criteria defined risk groups (RG). The median survivor follow-up was 7 years. Biochemical disease-free survival (bDFS) was reported by clinical nadir +2 ng/mL (CN+2) criteria. Statistical analyses included Kaplan-Meier, multivariate analysis, and Concordance-index models. Results: At 10-year analyses, overall survival was 84.8% and bDFS was 84.6%. With stratification by RG, CN+2 bDFS was 93.5% for the low-RG (n = 116), 78.7% for the intermediate-RG (n = 94), and 68.8% for the high-RG (n = 29), p = 0.0002. With stratification by pretreatment SPECT/CT findings, bDFS was 65.5% in patients with suspected mets (n = 22) vs. 86.6% in patients with only localized uptake (n = 217), p = 0.0014. CaP disease-specific survival (DSS) was 97.7% for the cohort. With stratification by SPECT/CT findings, DSS was 86.4% (with suspected mets) vs. 99.0% (localized only), p = 0.0001. Using multivariate analysis, the DSS hazard ratio for SPECT/CT findings (mets vs. localized) was 3.58 (p = 0.0026). Concordance

  5. RNAi2015 - Ten years of RNAi Oxford.

    PubMed

    Bewicke-Copley, Findlay; Samuel, Priya; Carter, David Rf

    2015-01-01

    The tenth RNAi conference was held at St. Hilda's College Oxford on the 24-26 March 2015. The conference offered researchers from all over the world the chance to present, discuss and discover work pertaining to the field of RNAi. RNAi has become an essential technique in genomic research for functional validation as well as an exciting avenue to explore in therapeutic medicine. Emerging techniques such as CRISPR as well as improvements in efficiency of existing techniques and expansions in libraries have cemented the importance of RNAi at the cutting edge of research. Featured presentations and posters showcased recent research in the field ranging from RNA detection in bio fluids through to potential oligonucleotide therapies. PMID:26557153

  6. A CAS Project Ten Years On

    ERIC Educational Resources Information Center

    Garner, Sue; Pierce, Robyn

    2016-01-01

    Although research shows that Computer Algebra Systems offer pedagogical opportunities, more than a decade later some teachers are reluctant to change established practices. In 2002, the University of Melbourne in Australia launched a research project to investigate implementation of a senior mathematics course in which students could use a…

  7. Ten Years of ODAS in Retrospect

    ERIC Educational Resources Information Center

    Simon, Arthur B.

    1974-01-01

    Reviewed are growth, activities, and changes of the Oral Deaf Adults Section (ODAS) of the Alexander Graham Bell Association since its establishment in 1964 to aid adjustment of the deaf to society. (MC)

  8. The Columbine Tragedy Ten Years Later

    ERIC Educational Resources Information Center

    Hammond, Jane

    2009-01-01

    Some tragedies are so emblazoned in people's minds that years later they can recall where they were when they first heard the news. The assassinations of John F. Kennedy and Martin Luther King Jr., the Challenger explosion, and the Sept. 11 terrorist attacks are among these events. So also is the Columbine High School tragedy of April 20, 1999.…

  9. Ten years of the Chernobyl era

    SciTech Connect

    Shcherbak, Y.M.

    1996-04-01

    A decade ago reactor number 4 at the Chernobyl nuclear power plant exploded, showering much of eastern Europe with radioactive debris. The Ukranian ambassador to the U.S., who was one of the medical researchers in Kiev and one of the first physicians to treat wounded, looks at the medical aftermath of the accident. He also contemplates what additional technological and political measures need to be taken to contain the lasting danger. 4 refs.

  10. Ten Years of Change in Executive Education.

    ERIC Educational Resources Information Center

    Bolt, James F.

    1993-01-01

    As recently as the 1980s, most companies did not pay much attention to executive education. In the 1990s, many see executive education as a must for revamping competitive strategies, increasing productivity, improving quality, reducing cycle time, and revitalizing corporate culture. (Author/JOW)

  11. Nanotoxicology ten years later: Lights and shadows.

    PubMed

    Shvedova, Anna; Pietroiusti, Antonio; Kagan, Valerian

    2016-05-15

    The mounting societal concerns about possible and maybe even likely adverse effects of nanomaterials are reflected in a large and growing number of publications in the field of nanotoxicology. Indeed, today's search in PubMed reveals >3700 publications on the subject denoted by (toxic+nanomaterials) - quite a growth over the last decade that began with only two dozens of them up-to 2005. PMID:26908175

  12. [Munchausen disease diagnosed ten years after debut].

    PubMed

    Mrgan, Monija; Taasti, Lena Merete

    2013-09-01

    Munchausen disease is difficult to diagnose especially because it is often an exclusion diagnosis. We present a case of skin ulcers in a young woman, who was eventually diagnosed with Munchausen disease. PMID:23992908

  13. Firework injuries: a ten-year study.

    PubMed

    Puri, Vinita; Mahendru, Sanjay; Rana, Roshani; Deshpande, Manish

    2009-09-01

    Fireworks are used worldwide to celebrate popular events (e.g. festivals, official celebrations, weddings). The festival of lights (Diwali) is celebrated with fireworks in India. During this period, many patients from all age groups present to hospital with injuries due to fireworks. Prevalence, period of occurrence, sex and age variation, adult supervision, causative fireworks, mode of lighting, age groups prone to injury, patterns of injury caused by individual fireworks, and the body parts injured were studied. One hundred and fifty-seven cases (92 retrospective, 65 prospective) with injury due to fireworks presenting to the Department of Plastic Surgery at KEM Hospital between 1997 and 2006 were studied. The prevalence of injuries has decreased steadily over the last 10 years (41 cases in 1997, 3 cases in 2006). The maximum number of injuries (35%) was seen in the age group 5-14 years; 92% of these children were unsupervised. The commonest cause of injury was firework misuse (41% of cases), followed by device failure (35%). Device failure was commonest with flares/fountains (ground firework emitting sparks upwards) and aerial devices. Flare/fountains caused most injury (39%), sparklers the least (0.6%). Flare/fountains, ground spinners, sparklers, and gunpowder (explosive material from cracker, obtained by tearing paper wrapper and obtaining chemicals) caused only soft tissue burns; stringbombs (high-intensity fire cracker made by wrapping chemicals with jute strings/coir in layers) and rockets (aerial device that zooms upwards and bursts) caused blast injuries, leading to soft tissue disruption and bony injuries. Emergency surgery was done if indicated: tendon and/or neurovascular repair, fracture fixation, flap cover or amputation. Superficial burns were treated with dressings. Certain wounds needed only thorough cleansing of the wound and primary suturing. We concluded that, over a 10-year period, the prevalence of firework injury decreased due to increased awareness in the community. Aggressive awareness campaigns by government and non-government organisations was the cause. We can minimise the number and severity of accidents by raising awareness regarding safety precautions, encouraging professional displays and motivating manufacturers to adhere to strict quality control. PMID:18603491

  14. Women and work: a ten year retrospective.

    PubMed

    MacRae, Nancy

    2005-01-01

    A look back, after a decade, at the issues surrounding women and work. Work options, childcare and family concerns, the glass ceiling, sexual harassment, women entrepreneurs, race and poverty, unpaid work, and women with disabilities are discussed. PMID:15920308

  15. Will CCSSM Matter in Ten Years?

    ERIC Educational Resources Information Center

    Larson, Matthew R.

    2012-01-01

    As elementary educators across the country begin to interpret the Common Core State Standards for Mathematics (CCSSI 2010) and put them into practice, this article takes a look at this latest set of mathematics standards from a historical viewpoint. The author discusses how educators might use a historical perspective to make the outcome of…

  16. The Next Ten Years in Education.

    ERIC Educational Resources Information Center

    Dede, Chris

    A person's beliefs about the future are very powerful in shaping his or her actions. The issue of what image of the next 10 years is most appropriate for educators today can be examined metaphorically with differing visions of what education can become. By using a series of predictions and by consolidating forecasts from futures research,…

  17. Ten-year space launch technology plan

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This document is the response to the National Space Policy Directive-4 (NSPD-4), signed by the President on 10 Jul. 1991. Directive NSPD-4 calls upon the Department of Defense (DoD), the Department of Energy (DOE), and the National Aeronautics and Space Administration (NASA) to coordinate national space launch technology efforts and to jointly prepare a 10-year space launch technology plan. The nation's future in space rests on the strength of its national launch technology program. This plan documents our current launch technology efforts, plans for future initiatives in this arena, and the overarching philosophy that links these activities into an integrated national technology program.

  18. Ten Years of the Armenian Virtual Observatory

    NASA Astrophysics Data System (ADS)

    Mickaelian, A. M.; Astsatryan, H. V.; Knyazyan, A. V.; Magakian, T. Yu.; Mikayelyan, G. A.; Erastova, L. K.; Hovhannisyan, L. R.; Sargsyan, L. A.; Sinamyan, P. K.

    2016-06-01

    Armenian Virtual Observatory (ArVO, www.aras.am/Arvo/arvo.htm) was created 10 years ago, in 2005, when after the accomplishment of the Digitized First Byurakan Survey (DFBS, www.aras.am/Dfbs/dfbs.html) we had enough resources to run a VO project and contribute in the International Virtual Observatory Alliance (IVOA, www.ivoa.net). ArVO is a project of Byurakan Astrophysical Observatory (BAO) aimed at construction of a modern system for data archiving, extraction, acquisition, reduction, use and publication. ArVO technical and research projects include Global Spectroscopic Database, which is being built based on DFBS. Quick optical identification of radio, IR or X-ray sources will be possible by plotting their positions in the DFBS or other spectroscopic plate and matching all available data. Accomplishment of new projects by combining data is so important that the International Council of Scientific Unions (ICSU) recently created World Data System (WDS, www.icsu-wds.org/) for unifying data coming from all science areas, and BAO has also joined it due to DFBS and ArVO projects.

  19. Poor mid-term survival of the low-carbide metal-on-metal Zweymüller-plus total hip arthroplasty system: a concise follow-up, at a minimum of ten years, of a previous report*.

    PubMed

    Repantis, Thomas; Vitsas, Vasilis; Korovessis, Panagiotis

    2013-03-20

    Between 1994 and 1999, 217 metal-on-metal total hip arthroplasties with a low-carbide bearing surface were performed with use of the cementless Zweymüller SL-Plus stem and the Bicon-Plus threaded cup in 194 consecutive patients. After a minimum follow-up of ten years, 181 living patients (203 hips) were available for evaluation. The revision rate after an average of twelve years was 18% (thirty-six hips in thirty-six patients were revised). The main reason for revision was aseptic loosening of one or both components. The probability of survival of the stem at fifteen years was 77% (95% confidence interval [CI], 65% to 86%). The probability of survival of the cup was 80% (95% CI, 62% to 90%). These high failure rates at mid-term follow-up led us to abandon the use of low-carbide metal-on-metal total hip arthroplasty components. PMID:23515994

  20. Diagnosis of myasthenia gravis: Comparison of anti-nicotinic acetyl choline receptor antibodies, repetitive nerve stimulation and Neostigmine tests at a tertiary neuro care centre in India, a ten year study.

    PubMed

    Patil, Shripad A; Bokoliya, Suresh C; Nagappa, Madhu; Taly, Arun B

    2016-03-15

    Anti-nicotinic AChR antibodies (Anti-nAChR antibodies), Repetitive Nerve Stimulation (RNS) and Neostigmine test are used for diagnosis of myasthenia gravis (MG). We compared their diagnostic agreement in a cohort of 486 MG patients over a period of ten years. Anti-nAChR antibodies, RNS and Neostigmine test showed positivity of 57.36%, 51.78%, and 93.4% respectively in ocular myasthenia and 93.77%, 82.35%, and 97.92% respectively in generalized myasthenia group. Neostigmine test showed higher positivity than anti-nAChR antibodies and RNS test in both groups. A marginal to fair agreement was observed between these tests highlighting their significance in the diagnosis of the disease. PMID:26943963

  1. Deburring and surface finishing: The past ten years and projections for the next ten years

    SciTech Connect

    Gillespie, L.K.

    1990-09-01

    The 1970s were a decade of significant growth in deburring and surface finishing. In the 1980s progress was made in robotic finishing, burr formation models, surface finish measurement, new processes, equipment and tooling. The centers of burr and surface related research changed. The decade of the 1990s will bring greater competition, environmental restrictions, more processes, more automation, and better characterization and simulation of processes.

  2. A ten-year surveillance study of carbapenemase-producing Klebsiella pneumoniae in a tertiary care Greek university hospital: predominance of KPC- over VIM- or NDM-producing isolates.

    PubMed

    Spyropoulou, Aikaterini; Papadimitriou-Olivgeris, Matthaios; Bartzavali, Christina; Vamvakopoulou, Sophia; Marangos, Markos; Spiliopoulou, Iris; Anastassiou, Evangelos D; Christofidou, Myrto

    2016-03-01

    Resistance patterns and carbapenemase gene presence among Klebsiella pneumoniae isolates from the University General Hospital of Patras, Greece during a ten-year period were analysed under a surveillance programme for multi-drug-resistant bacteria. From 2005 to 2014, K. pneumoniae isolates from clinically significant specimens were identified by the Vitek 2 Advanced Expert System. Antibiotic susceptibility testing was performed by the agar disc diffusion method and Etest. The strains were tested for the presence of blaVIM, blaIMP, blaKPC, blaNDM and blaOXA-48 genes by PCR. PFGE of chromosomal Xbal DNA digests was performed. A total of 3449 K. pneumoniae isolates were recovered during the last decade. Among them, 1668 (48 %) were carbapenemase-producing: 1333 (80 %) K. pneumoniae carbapenemase (KPC)-, 286 (17 %) Verona imipenemase (VIM), 45 (3 %) KPC- and VIM-, and four New Delhi metallo-beta-lactamase (NDM)-producing. Their resistance rates to gentamicin, colistin and tigecycline were 41 %, 23 % and 16 %, respectively. VIM-producing K. pneumoniae were isolated in 2005 and since 2008 have been endemic. KPC-producing K. pneumoniae (KPC-Kp) isolates were introduced in 2008 and until now represent the predominant carbapenemase-producing K. pneumoniae in our institution. PFGE of 97 KPC-Kp strains identified three types: A, 84 (87 %); B, 11 (11 %); and E, two (2 %). Eleven co-producing KPC and VIM K. pneumoniae isolates belonged to PFGE B. The four NDM-positives were classified to type F. The number of K. pneumoniae bacteraemias increased during the study period, which may be solely attributed to the increase of carbapenemase-producing isolates. The threat of carbapenemase-producing K. pneumoniae emphasizes the urgent need for implementation of infection control measures and budgetary allocations to infection control. PMID:26698320

  3. Findings in pinnipeds stranded along the central and northern California coast, 1984-1990.

    PubMed

    Gerber, J A; Roletto, J; Morgan, L E; Smith, D M; Gage, L J

    1993-07-01

    Personnel at The Marine Mammal Center (The Center) treated 1,446 stranded marine mammals recovered from the central and northern California (USA) coast from 1984 through 1990, including California sea lions (Zalophus californianus), northern elephant seals (Mirounga angustirostris), Pacific harbor seals (Phoca vitulina richardsi), northern fur seals (Callorhinus ursinus), Steller sea lions (Eumetopias jubatus), and Guadalupe fur seals (Arctocephalus townsendi). The primary disease findings in stranded California sea lions were renal disease, renal disease complicated by severe verminous pneumonia, verminous pneumonia, seizures of unknown etiology, and renal disease complicated by severe pneumonia of unknown etiology. Stranded elephant seals included pups, yearlings with dermatological problems, and neonates. Most harbor seals admitted to The Center were underweight and premature pups. Stranded northern fur seals included animals with seizures of unknown etiology and emaciated pups. Stranded Steller sea lions included underweight pups and aged adult females with pneumonia. Two Guadalupe fur seals had hemorrhagic gastroenteritis. Incidental findings at the time of stranding among the six species included verminous pneumonia and pneumonia of unknown etiology, renal disease, internal parasitism, ophthalmologic problems, gastrointestinal disorders, otitis externa, and external wounds. PMID:8355344

  4. Results.

    ERIC Educational Resources Information Center

    Zemsky, Robert; Shaman, Susan; Shapiro, Daniel B.

    2001-01-01

    Describes the Collegiate Results Instrument (CRI), which measures a range of collegiate outcomes for alumni 6 years after graduation. The CRI was designed to target alumni from institutions across market segments and assess their values, abilities, work skills, occupations, and pursuit of lifelong learning. (EV)

  5. Ten-Year Check-Up: Have Federal Agencies Responded to Civil Rights Recommendations? Volume IV: An Evaluation of the Departments of Education, Health and Human Services, and Housing and Urban Development, and the Equal Opportunity Commission

    ERIC Educational Resources Information Center

    MacDougall, Sock-Foon C.; Butler, Margaret; Johnson, Wanda

    2004-01-01

    During this four-volume study, the U.S. Commission on Civil Rights evaluated 11 federal agencies to determine whether or not they have responded to recommendations offered in previous reports and if civil rights enforcement improved as a result. Throughout the volumes, the Commission has identified good and inadequate civil rights practices that…

  6. Examination of body burden and taint for Iceland scallop (Chlamys islandica) and American plaice (Hippoglossoides platessoides) near the Terra Nova offshore oil development over ten years of drilling on the Grand Banks of Newfoundland, Canada

    NASA Astrophysics Data System (ADS)

    DeBlois, Elisabeth M.; Kiceniuk, Joe W.; Paine, Michael D.; Kilgour, Bruce W.; Tracy, Ellen; Crowley, Roger D.; Williams, Urban P.; Gregory Janes, G.

    2014-12-01

    This paper presents results of analyses of body burdens of metals and hydrocarbons, and taste tests for taint, in Iceland scallop and American plaice performed as part of the Environmental Effects Monitoring (EEM) program for the Terra Nova offshore oil development (Grand Banks of Newfoundland, Canada). Scallop and plaice were collected in a Study Area located within approximately 1 km of drill centres at Terra Nova and in a Reference Area located approximately 20 km from the development. Samples were collected in 1997 to establish a baseline, and from 2000 to 2010, during drilling periods. Scallop adductor muscle tissue was contaminated with >C10-C21 aliphatic hydrocarbons resembling the drilling fluid in the synthetic drilling mud (SBM) used at Terra Nova in 2000, 2002 and 2004, but contamination of adductor muscle was not noted in 2006, 2008 and 2010. The maximum concentration in muscle was 28 mg/kg wet weight, noted in 2002. Scallop viscera was contaminated with hydrocarbons resembling drilling fluid in SBMs near drill centres in all EEM years except 2010. Viscera contamination with >C10-C21 hydrocarbons gradually decreased from a maximum of 150 mg/kg in 2000, to a maximum of 27 mg/kg in 2008; all values were below the laboratory reporting detection limit of 15 mg/kg in 2010. Therefore, evidence from both muscle and viscera indicates a decrease in tissue hydrocarbon contamination in recent years. Barium, another major constituent in drilling muds, has not been noted in scallop adductor muscles at concentrations above the reporting detection limit, but barium was detected in viscera in baseline and EEM years. The maximum concentration of barium in viscera during baseline sampling was 8 mg/kg. The maximum concentration in EEM years (29 mg/kg) was noted in 2000. The maximum concentration in 2010 was 25 mg/kg. The concentration of metals other than barium in scallop tissues was similar between the Terra Nova Study Area and the Reference Area. Hydrocarbons

  7. Ten years later: Evaluation of the effectiveness of 12.5% amitraz against a field population of Rhipicephalus (Boophilus) microplus using field studies, artificial infestation (Stall tests) and adult immersion tests.

    PubMed

    Maciel, Willian Giquelin; Lopes, Welber Daniel Zanetti; Cruz, Breno Cayeiro; Gomes, Lucas Vinicius Costa; Teixeira, Weslen Fabrício Pires; Buzzulini, Carolina; Bichuette, Murilo Abud; Campos, Gabriel Pimentel; Felippelli, Gustavo; Soares, Vando Edésio; de Oliveira, Gilson Pereira; da Costa, Alvimar José

    2015-12-15

    Using field trials, artificial infestations (Stall tests) and in vitro adult immersion tests, the present study evaluated the acaricidal efficacy of 12.5% amitraz administered via whole body spraying against a Rhipicephalus (Boophilus) microplus population that did not have any contact with chemical products belonging to this acaricide family for 10 years (approximately 40 generations). Two natural infestation trials, two artificial infestation trials (Stall tests) and two adult immersion tests were performed in two different stages in 2005 and 2015. Between 2002 and 2015, the bovine herd of this property was formed by approximately 450 animals from the Simmental breed that were divided into nine paddocks formed by Cynodon dactylon (L.) Pers. For the natural infestation experiments in 2005 and 2015, we selected nearly 70 animals naturally infested with ticks from the same herd that belonged to the "São Paulo" farm located in São José do Rio Pardo, São Paulo, Brazil. Field studies were performed in the same paddock (9). To evaluate anti-R. (B.) microplus activity in the artificially infested cattle (Stall tests) and adult immersion tests, two experiments of each methodology were performed at CPPAR (the Center of Research in Animal Health located on the FCAV/UNESP campus in Jaboticabal, São Paulo, Brazil) in 2005 and 2015. R. (B.) microplus used in the artificial infestation, and adult immersion test experiments were obtained from paddocks 1-9 in 2005 and 2015 from the commercial farm where the field studies were performed. Based on the obtained results, it was possible to conclude that amitraz use in rotation with pyrethroids every 28 days for three consecutive years (2002-2004) previous to the beginning of the first trial (2005) was sufficient to generate a R. (B.) microplus strain resistant to amitraz. Moreover, using field trials, artificial infestations (Stall tests) and adult immersion tests, we verified that 40 generations of the tick species with no

  8. UPDATING AN EXPERT ELICITATION IN THE LIGHT OF NEW DATA: TEN YEARS OF PROBABILISTIC VOLCANIC HAZARD ANALYSIS FOR THE PROPOSED HIGH-LEVEL RADIOACTIVE WASTE REPOSITORY AT YUCCA MOUNTAIN, NEVADA

    SciTech Connect

    F.V. Perry; A. Cogbill; R. Kelley

    2005-08-26

    The U.S. Department of Energy (DOE) considers volcanism to be a potentially disruptive class of events that could affect the safety of the proposed high-level waste repository at Yucca Mountain. Volcanic hazard assessment in monogenetic volcanic fields depends on an adequate understanding of the temporal and spatial pattern of past eruptions. At Yucca Mountain, the hazard is due to an 11 Ma-history of basaltic volcanism with the latest eruptions occurring in three Pleistocene episodes to the west and south of Yucca Mountain. An expert elicitation convened in 1995-1996 by the DOE estimated the mean hazard of volcanic disruption of the repository as slightly greater than 10{sup -8} dike intersections per year with an uncertainty of about two orders of magnitude. Several boreholes in the region have encountered buried basalt in alluvial-filled basins; the youngest of these basalts is dated at 3.8 Ma. The possibility of additional buried basalt centers is indicated by a previous regional aeromagnetic survey conducted by the USGS that detected approximately 20 magnetic anomalies that could represent buried basalt volcanoes. Sensitivity studies indicate that the postulated presence of buried post-Miocene volcanoes to the east of Yucca Mountain could increase the hazard by an order of magnitude, and potentially significantly impact the results of the earlier expert elicitation. Our interpretation of the aeromagnetic data indicates that post-Miocene basalts are not present east of Yucca Mountain, but that magnetic anomalies instead represent faulted and buried Miocene basalt that correlates with nearby surface exposures. This interpretation is being tested by drilling. The possibility of uncharacterized buried volcanoes that could significantly change hazard estimates led DOE to support an update of the expert elicitation in 2004-2006. In support of the expert elicitation data needs, the DOE is sponsoring (1) a new higher-resolution, helicopter-borne aeromagnetic survey

  9. Ten years' experience with four cycles of bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, prednisone, procarbazine (BEACOPP)-escalated followed by four cycles of baseline-dose BEACOPP in patients with advanced stage Hodgkin lymphoma: a single-center, retrospective study.

    PubMed

    Belada, David; Štěpánková, Pavla; Sýkorová, Alice; Žák, Pavel; Smolej, Lukáš

    2015-07-01

    The HD-9 trial showed that eight cycles of BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, prednisone, procarbazine)-escalated led to significant improvements in response rate, progression-free survival and overall survival over COPP/ABVD (cyclophosphamide, vincristine, prednisone, procarbazine/doxorubicin, bleomycin, vinblastine, dacarbazine) therapy. This monocentric retrospective study was performed to evaluate 10 years of experience with four cycles of BEACOPP-escalated and four cycles of BEACOPP-baseline outside of clinical trials. The outcomes were assessed in 78 patients with newly diagnosed advanced stage Hodgkin lymphoma. A complete response after chemotherapy ± radiotherapy was achieved in 75 patients (96%). At the median follow-up of 74 months, the actuarial 5- and 10-year freedom from treatment failure (FFTF) rates were 91% and 89%, and actuarial 5- and 10-year overall survival rates for the entire group were 93% and 90%, respectively. These results suggest that the combination of escalated and baseline BEACOPP chemotherapy is feasible in routine practice with good efficacy and acceptable toxicity. PMID:25330440

  10. Association of helicobacter pylori infection and chronic atrophic gastritis with risk of colonic, pancreatic and gastric cancer: A ten-year follow-up of the ESTHER cohort study

    PubMed Central

    Castro, Felipe Andres; Chen, Hongda; Zhang, Yan; Holleczek, Bernd; Brenner, Hermann

    2016-01-01

    Objectives To assess the association of H. pylori and chronic atrophic gastritis (AG) with colonic, pancreatic and gastric cancer in a population-based prospective cohort. Methods Serum antibodies against H. pylori in general and specific to cytotoxin-associated gene A (CagA), as well as serum pepsinogen I and II were analyzed in 9,506 men and women, aged 50–75 years in a cohort study from Saarland, Germany. Incident cases of colonic, pancreatic and gastric cancer were ascertained by record linkage with data from the Saarland Cancer Registry. Results During an average follow-up of 10.6 years, 108 colonic, 46 pancreatic and 27 gastric incident cancers were recorded. There was no association between H. pylori infection and colonic cancer (HR = 1.07; 95% CI 0.73–1.56) or pancreatic cancer (HR = 1.32; 0.73–2.39), regardless of either CagA seropositivity or AG status. In contrast, CagA+ infection was associated with a strongly increased risk of gastric cancer, especially non-cardia gastric cancer, and this association was particularly pronounced in the presence of AG. Compared to people without AG and without CagA+ infection, people with both risk factors had a significantly increased risk of non-cardia gastric cancer (HR = 32.4; 7.6–137.6). Conclusions This large cohort study did not observe an association of H. pylori infection or AG with colonic or pancreatic cancer, but underlines that the vast majority of non-cardia gastric cancers arise from AG and infection with CagA+ H. pylori strains. PMID:26958813

  11. Analysis of DAX1 (NR0B1) and steroidogenic factor-1 (SF1/Ad4BP, NR5A1) in children and adults with primary adrenal failure: ten years' experience

    PubMed Central

    Lin, Lin; Gu, Wen-Xia; Ozisik, Gokhan; To, Wing S.; Owen, Catherine J.; Jameson, J. Larry; Achermann, John C.

    2007-01-01

    Context Primary adrenal failure is a life-threatening condition that can be caused by a range of etiologies, including autoimmune, metabolic, and developmental disorders. The nuclear receptors DAX1 (NR0B1) and steroidogenic factor-1 (SF1/Ad4BP, NR5A1) play an important role in adrenal development and function, and mutations in these transcription factors have been found in patients with adrenal hypoplasia. Objective To investigate the prevalence of DAX1 and SF1 mutations in children and adults with primary adrenal failure of unknown etiology (i.e., not caused by congenital adrenal hyperplasia, adrenoleukodystrophy, autoimmune disease). Patients One-hundred and seventeen patients were included. Eighty-eight individuals presented in infancy or childhood with adrenal hypoplasia or primary adrenal failure of unknown etiology (n=64, 46,XY phenotypic males; n=17, 46,XY gonadal dysgenesis/impaired androgenization; n=7, 46,XX females). Twenty-nine individuals presented in adulthood with “Addison disease” of unknown etiology. Methods Mutational analysis of DAX1 (NR0B1) (including exon 2α/1A) and SF1 (NR5A1) by direct sequencing. Results DAX1 mutations were found in 58% (37/64) of 46,XY phenotypic boys referred with adrenal hypoplasia, and in all boys (8/8) with hypogonadotropic hypogonadism and a family history suggestive of adrenal failure in males. SF1 mutations causing adrenal failure were found only in two patients with 46,XY gonadal dysgenesis. No DAX1 or SF1 mutations were identified in the adult-onset group. Conclusions DAX1 mutations are a relatively frequent cause of adrenal failure in this group of boys. SF1 mutations causing adrenal failure in humans are rare and are more likely to be associated with significant underandrogenization and gonadal dysfunction in 46,XY individuals. PMID:16684822

  12. Ten Years of Experience with the GORE EXCLUDER{sup Registered-Sign} Stent-Graft for the Treatment of Aortic and Iliac Aneurysms: Outcomes from a Single Center Study

    SciTech Connect

    Maleux, G. Claes, H.; Van Holsbeeck, A.; Janssen, R.; Laenen, A.; Heye, S.; Houthoofd, S.; Fourneau, I.

    2012-06-15

    Purpose: This study was designed to assess the long-term outcome of selected patients with aortic, aortoiliac, and isolated common iliac aneurysms treated with the GORE EXCLUDER{sup Registered-Sign} stent-graft. Methods: Between December 1998 and June 2010, 121 nonconsecutive patients underwent insertion of a GORE EXCLUDER{sup Registered-Sign} stent-graft to treat an aortic (n = 80; 66%), aortoiliac (n = 25; 21%), or isolated common iliac (n = 16; 13%) aneurysm. Procedural and follow-up data were collected prospectively. Primary endpoints are overall survival, intervention-free survival, and freedom from aneurysm rupture. Secondary endpoints are device- and procedure-related complications, including all types of endoleaks or endotension, and reintervention. Results: The mean follow-up is 4.98 years (standard deviation, 3.18; median follow-up, 4.05 years). The estimated percentage overall survival (with 95% confidence interval) after respectively 5 and 10 years of follow-up is 74.5% (65.8; 81.3) and 57.8% (47.7; 66.7). The estimated intervention-free survival after respectively 5 and 10 years is 90% (84.3; 96.1) and 77.7% (67; 88.4). There was no aneurysm rupture during follow-up. Early postoperative complications occurred in 16 patients (13%); none were fatal. Late reinterventions were performed in 18 patients (15%). Finally, throughout the follow-up period, endoleaks were identified: type I (n = 4; 3%); type II (n = 39; 32%); type III (n = 0; 0%); endotension was seen in 11 patients (9%). Conclusions: Aneurysm exclusion with use of the GORE EXCLUDER{sup Registered-Sign} stent-graft is durable through a mean follow-up of nearly 5 years. There was no postprocedural aneurysm rupture. Complications occurred throughout the follow-up period, requiring continued clinical and radiological surveillance.

  13. Ten years of Nature Physics: Go with the flow

    NASA Astrophysics Data System (ADS)

    Garstecki, Piotr; Hołyst, Robert

    2015-04-01

    A 2006 Nature Physics paper reported phonons in a one-dimensional crystal of aqueous droplets traversing a laminar oil flow -- putting microfluidics on the map as a tool for unravelling the mechanisms behind regularity in thermodynamically open systems.

  14. Landamatics Ten Years Later: An Interview with Lev N. Landa.

    ERIC Educational Resources Information Center

    Educational Technology, 1993

    1993-01-01

    Provides the transcript of an interview with Dr. Lev Landa that addressed issues related to his algorithmico-heuristic theories of learning and instruction, called Landamatics. Highlights include teaching thinking versus knowledge; algorithms; instructional design; improving training and performance in industry, business, and government;…

  15. The Higher Education Prison Program: The First Ten Years.

    ERIC Educational Resources Information Center

    Tobin, Patricia L.

    The first 10 years of operation of the college-in-prison program in Massachussetts and characteristics of participating offenders were assessed. College credit courses have been offered to inmates in adult corrections facilities by The University of Massachusetts at Boston through a program called the Higher Education Prison Program (HEPP).…

  16. A Roadmap for IT Leadership and the Next Ten Years

    ERIC Educational Resources Information Center

    Chester, Timothy M.

    2006-01-01

    Shortly after becoming a CIO (Chief Information Officer), the author read an article by Gregory Jackson in the January 2004 Chronicle of Higher Education entitled, "A CIO's Question: Will You Still Need Me When I'm 64?" Jackson, one of the most widely known and respected CIOs in higher education, argued that CIOs in higher education face four…

  17. Ten-year SETI begins - NASA listens for cosmic intelligence

    NASA Astrophysics Data System (ADS)

    Shostak, Seth

    1993-04-01

    Technical features of new investigations conducted in the framework of the SETI experiment, managed by NASA's Ames Research Center, are described. On october 12 1992 NASA began a decade-long project, referred to as the High Resolution Microwave Survey, to search for signs of life in the Galaxy by activating new state-of-the-art radio receivers in Puerto Rico and California.

  18. Spaulding and Materazzi Revisited: A Ten Year Retrospect.

    ERIC Educational Resources Information Center

    Bourke, Thomas A.

    1988-01-01

    Summarizes the ANSI standards for archival film and looks at the debate surrounding questions of archival storage, durability in a working environment, and affordability among proponents of silver halide, diazo, and vesicular films. Articles written by Carl Spaulding and Albert R. Materazzi on the subject are reviewed. (11 references) (MES)

  19. Chernobyl and Bhopal ten years on comparisons and contrasts

    SciTech Connect

    Grimston, M.C.

    1997-03-01

    Within eighteen months in mid- 1980s, two of the most serious industrial accidents in history occurred. At Bhopal, capital of Madhya Pradesh in central India, in the early hours of December 3, 1984, an explosion occurred at Union Carbide of India Ltd (UCIL)`s methyl isocyanate plant. Some 40 tonnes of a complex chemical mixture were released, causing several thousand deaths and hundreds of thousands of injuries. At Chernobyl in the north of Ukraine, then part of the USSR, in the early hours of April 26, 1986, an explosion at a state-owned nuclear power plant caused the release of some 6 tonnes (possibly more) of radioactive materials. The {open_quote}immediate{close_quote} death toll was much lower than at Bhopal. The usually-quoted figure of 30, all of whom were on site in the immediate aftermath of the explosion, includes two who died on site from burns and falling masonry and 28 who died within the following few weeks from Acute Radiation Syndrome. (Another person on site died of a heart attack, which it is difficult to associate directly with the accident.) However, the effects of the accident were widespread, especially in Belarus, Ukraine and Russia, and theoretical calculations suggest that further illness and premature deaths are to be expected for several years to come. This paper compares and contrasts these two accidents. There are striking similarities.

  20. Ten-year follow-up of a giant prolactinoma.

    PubMed

    Fernandes, Vera; Santos, Maria Joana; Almeida, Rui; Marques, Olinda

    2015-01-01

    Giant prolactinomas are rare pituitary tumours of which management can be a challenge. A 28-year-old man presented with headaches, visual impairment and behavioural changes. Clinically, the patient was found to have hypogonadism and bitemporal hemianopsia. A MRI demonstrated a pituitary tumour 76 mm in diameter and blood tests revealed a serum prolactin of 158,700 µU/mL (reference range 58-254). Initially, a craniotomy was performed. Immunohistochemistry of the tumour identified a prolactinoma with a high proliferative index and the patient was started on treatment with a dopamine agonist. A year later, neurological symptoms worsened due to regrowth of the lesion's cystic component, and so further surgery was performed. After 10 years of treatment with dopamine agonists, the prolactin levels decreased by 96.8%, there was an effective reduction in tumour size, and the neurological signs and symptoms resolved. PMID:26590188

  1. Ten years of structural reforms in Danish healthcare.

    PubMed

    Christiansen, Terkel

    2012-07-01

    A major structural reform of the Danish public sector took place in 2007 when the number of administrative units at the regional and municipal levels was reduced. The larger administrative units allowed for a new hospital structure with a reduced number of acute hospitals covering a population of between 200,000 and 400,000 inhabitants. The restructuring involves creation of acute hospitals with a 24-h acute service by a range of specialists. The idea was to weight quality higher than geographical closeness to the nearest hospital. Concurrently, the pre-hospital service will be expanded. The National Board of Health was given authority to approve regional plans for specialties rather than provide guidelines. The use of private hospitals was increased as a means to fulfil a waiting time guarantee of between 2 and 1 month. Increased use of private insurance also increased use of private hospitals. A new way of financing health care was intended to give municipalities incentives to invest in health prevention and health promotion. Concurrent reforms included economic incentives to increase hospital production as measured by DRGs; quality programmes to secure high quality and patient safety; and electronic patient records and increased use of IT systems. PMID:22521580

  2. National Core Indicators: Ten Years of Collaborative Performance Measurement

    ERIC Educational Resources Information Center

    Bradley, Valerie J.; Moseley, Chas

    2007-01-01

    In the past 10 years, people have witnessed significant changes in the nature and extent of the publicly financed systems of services and supports for individuals with developmental disabilities and their families. Growing service needs, declining state revenues, mounting pressures on federal and state Medicaid budgets, and heightened federal…

  3. A Ten Year Citation Analysis of Major Australian Research Institutions

    ERIC Educational Resources Information Center

    Batterham, Robin J.

    2011-01-01

    The introduction of the Excellence in Research for Australia scheme has heightened debate amongst research institutions over the use of metrics such as citations, especially given the ready availability of citation data. An analysis is presented of the citation performance of nine Australian universities and the Commonwealth Scientific, Industrial…

  4. Ten years of HPV vaccines: State of art and controversies.

    PubMed

    Angioli, Roberto; Lopez, Salvatore; Aloisi, Alessia; Terranova, Corrado; De Cicco, Carlo; Scaletta, Giuseppe; Capriglione, Stella; Miranda, Andrea; Luvero, Daniela; Ricciardi, Roberto; Montera, Roberto; Plotti, Francesco

    2016-06-01

    The human papillomavirus (HPV) represents one of the most common sexually transmitted infections and it has been related to cervical cancer. The HPV vaccines prevent infection with certain species of HPV associated with the development of cervical cancer or genital warts. We carried out a PubMed search up to 2015 evaluating all randomized studies published in literature. This review discusses the current status of HPVs vaccines on the global market, efficacy, safety profiles, controversies and future vaccine developments. Three HPVs vaccines are currently on the global market: bivalent, quadrivalent and ninevalent. Bivalent and quadrivalent vaccines can protect against almost 70% of cervical HPV-related cancerous and precancerous conditions and the ninevalent vaccine, instead, provides a protection against almost 90%. The use of vaccinations raised several controversies in the last years and, currently, is not possible to establish which type of vaccine is most effective, however all of them are safe. PMID:27066937

  5. Ten Years of Cloud Optical and Microphysical Retrievals from MODIS

    NASA Astrophysics Data System (ADS)

    Platnick, S. E.; King, M. D.; Wind, G.; Hubanks, P.; Arnold, G. T.; Amarasinghe, N.

    2009-12-01

    The MODIS cloud optical properties algorithm (MOD06/MYD06 for Terra and Aqua MODIS, respectively) has undergone extensive improvements and enhancements since the launch of Terra. These changes have included: improvements in the cloud thermodynamic phase algorithm; substantial changes in the ice cloud light scattering look up tables (LUTs); a clear-sky restoral algorithm for flagging heavy aerosol and sunglint; greatly improved spectral surface albedo maps, including the spectral albedo of snow by ecosystem; inclusion of pixel-level uncertainty estimates for cloud optical thickness, effective radius, and water path derived for three error sources that includes the sensitivity of the retrievals to solar and viewing geometries. To improve overall retrieval quality, we have also implemented cloud edge removal and partly cloudy detection (using MOD35 cloud mask 250m tests), added a supplementary cloud optical thickness and effective radius algorithm over snow and sea ice surfaces and over the ocean, which enables comparison with the “standard” 2.1 µm effective radius retrieval, and added a multi-layer cloud detection algorithm. We will discuss the status of the MOD06 algorithm and show examples of pixel-level (Level-2) cloud retrievals for selected data granules, as well as gridded (Level-3) statistics, notably monthly means and histograms (1D and 2D, with the latter giving correlations between cloud optical thickness and effective radius, and other cloud product pairs).

  6. The Learning Organization Ten Years On: A Case Study.

    ERIC Educational Resources Information Center

    Smith, Peter A. C.

    1999-01-01

    A learning organization is viable when the learning climate successfully changes managers' mindsets. A case study of a financial services enterprise illustrates ways to keep mind sets from hardening and shows how changing learning activities and tools can change habits of thinking and learning. (Contains 30 references.) (SK)

  7. Ten year clinical experience with stroke and cerebral vasculitis.

    PubMed

    Kempster, Peter A; McLean, Catriona A; Phan, Thanh G

    2016-05-01

    Angiitis of the central nervous system (CNS) is difficult to diagnose but potentially fatal. When stroke occurs in a younger individual or is associated with multiple infarcts on imaging, clinicians must decide how far to pursue a possible diagnosis of vasculitis. The aim of this study is to establish the prevalence of primary and secondary cerebral angiitis among patients presenting with stroke. Hospital attendances over a 10year period were surveyed by searching for diagnostic codes and key words specific for cerebral vasculitis/angiitis. Case notes were reviewed by the authors using two sets of criteria for angiitis of the CNS. Thirty-two patients were initially considered likely to have cerebral angiitis by treating physicians. Thirteen had been admitted to hospital with stroke. During this period, there were 7475 admissions for ischaemic and haemorrhagic stroke. Six patients had a final diagnosis of vasculitic stroke but only one had definite CNS angiitis with a first presentation as ischaemic stroke (0.02%). Most patients who did have cerebral vasculitis developed multifocal or subacute neurological deficits, or already had an immunological disorder known to be associated with secondary CNS angiitis. Of 19 patients given an alternative final diagnosis, the most common were atherosclerotic/embolic cerebrovascular disease (n=9) and reversible cerebral vasoconstriction syndrome (n=7). Stroke is rarely the first manifestation of cerebral vasculitis. Our findings suggest that routine screening for angiitis in stroke patients may not be warranted. PMID:26778046

  8. A Ten-Year Look at State Park Systems.

    ERIC Educational Resources Information Center

    Martin, W. Donald

    1986-01-01

    State park agencies have weathered some adverse conditions during the last decade. Financial operations, park acreage and facilities, attendance, personnel and salaries, as well as per-visitor expenditures and revenues over the past 10 years are discussed. (MT)

  9. Integrative oncology: the last ten years--a personal retrospectve.

    PubMed

    Boyd, D Barry

    2007-01-01

    In the last decade, there has been dramatic changes in all areas of integrative patient care. None has been more dramatic than those in the field of cancer care, which has gone from alternative and complementary treatments delivered outside the conventional setting to the integration of many of these approaches into the care of the cancer patient. In many cases, these changes have been driven by patient demand and supported by private funding and out-of-pocket payments by patients themselves. Virtually all major medical centers have departments devoted to integrative patient care--whether true stand-alone centers or departments with a research interest in this area. This is particularly true of the major cancer centers, many of which-including Memorial Sloan Kettering Cancer Center, New York; M.D. Anderson Cancer Center, Houston, Tex; Johns Hopkins University, Baltimore, Md; Duke University, Durham, NC; and the Dana Farber Cancer Institute, Boston, Mass--have developed integrative cancer programs. In addition, programs such as the Cancer Treatment Centers of America have inpatient and outpatient programs with teams of practitioners, including medical oncologists, surgeons, and radiation therapists, as well as credentialed naturopathic doctors, nutritionists, mind-body specialists and other integrative practitioners. Despite the increased interest in developing integrative approaches to cancer, many medical oncologists remain skeptical about the value of these modalities. PMID:17283742

  10. Investigating Ten Years of Equity Policy in Australian Higher Education

    ERIC Educational Resources Information Center

    Coates, Hamish; Krause, Kerri-Lee

    2005-01-01

    This paper reports issues arising from a longitudinal study of 1991 to 2002 Australian higher education equity data. The national equity framework uses an empirical performance indicator system to monitor access, participation, success and retention of six designated equity groups. The paper examines three possible approaches for defining new…

  11. Ten-years degradation of resin-dentin bonds.

    PubMed

    Hashimoto, Masanori; Fujita, Shinichi; Nagano, Futami; Ohno, Hiroki; Endo, Kazuhiko

    2010-08-01

    The purpose of this study was to evaluate the durability of resin-dentin bonds in 10-yr water-storage testing. Resin-dentin bonded bulk specimens were prepared using six commercially available resin adhesives. The resin-dentin bonded specimens were stored in water for 24 h (control group) or for 10 yr (experimental groups). After each storage period, the specimens were sectioned to make specimen beams and then subjected to a microtensile bond test. After the bond test, fractured surfaces were examined by scanning electron microscopy (SEM). In addition, interfacial observation of silver nanoleakage was performed using the backscatter electron mode of SEM. The bond strengths of four of the six adhesive systems tested decreased significantly after 10 yr. However, no significant bond-strength reduction was recorded for the other two systems. The interfacial observations showed water tree propagation in the bonding resin layer as a typical morphological change after aging for five of the six adhesives tested. Water tree propagation may be a symptom of degradation in the resin bonding layer of resin-dentin bonds. PMID:20662915

  12. Ten years of Nature Physics: Numerical models come of age

    NASA Astrophysics Data System (ADS)

    Gull, E.; Millis, A. J.

    2015-10-01

    When Nature Physics celebrated 20 years of high-temperature superconductors, numerical approaches were on the periphery. Since then, new ideas implemented in new algorithms are leading to new insights.

  13. Renewing the Covenant: Ten Years after the Kellogg Commission

    ERIC Educational Resources Information Center

    Spanier, Graham B.

    2011-01-01

    This article presents the author's remarks at the 11th Annual National Outreach Scholarship Conference. The author offers five strategies for advancing engagement at colleges and universities: (1) each institution needs to focus on activities that play to its strengths; (2) colleges and universities need to advance access for nontraditional…

  14. Ten years after the embargo: efficiency versus recession

    SciTech Connect

    Not Available

    1983-01-01

    A 10-year review of the ''Energy Crisis'' years focuses primarily on the issue of energy conservation. The paper stresses the changing definition of the energy crisis from oil import insecurity to economic insecurity, and explores in each energy-consuming sector of the economy the major trends of energy demand over the last decade and the special impact of our changing energy climate on the poor. The report concludes that the US has made significant progress towards adjusting to a new era of expensive energy, but that progress is small relative to the potential for cost-effective energy conservation investments and energy savings. The major challenge still involves stimulating the marketplace to capture these savings through investments rather than through reductions in our standard of living or economic growth. The need remains to assist those who lack the funds for such investments so they can reduce the financial drain of energy waste. 31 tables.

  15. Ten years of dengue drug discovery: progress and prospects.

    PubMed

    Lim, Siew Pheng; Wang, Qing-Yin; Noble, Christian G; Chen, Yen-Liang; Dong, Hongping; Zou, Bin; Yokokawa, Fumiaki; Nilar, Shahul; Smith, Paul; Beer, David; Lescar, Julien; Shi, Pei-Yong

    2013-11-01

    To combat neglected diseases, the Novartis Institute of Tropical Diseases (NITD) was founded in 2002 through private-public funding from Novartis and the Singapore Economic Development Board. One of NITD's missions is to develop antivirals for dengue virus (DENV), the most prevalent mosquito-borne viral pathogen. Neither vaccine nor antiviral is currently available for DENV. Here we review the progress in dengue drug discovery made at NITD as well as the major discoveries made by academia and other companies. Four strategies have been pursued to identify inhibitors of DENV through targeting both viral and host proteins: (i) HTS (high-throughput screening) using virus replication assays; (ii) HTS using viral enzyme assays; (iii) structure-based in silico docking and rational design; (iv) repurposing hepatitis C virus inhibitors for DENV. Along the developmental process from hit finding to clinical candidate, many inhibitors did not advance beyond the stage of hit-to-lead optimization, due to their poor selectivity, physiochemical or pharmacokinetic properties. Only a few compounds showed efficacy in the AG129 DENV mouse model. Two nucleoside analogs, NITD-008 and Balapiravir, entered preclinical animal safety study and clinic trial, but both were terminated due to toxicity and lack of potency, respectively. Celgosivir, a host alpha-glucosidase inhibitor, is currently under clinical trial; its clinical efficacy remains to be determined. The knowledge accumulated during the past decade has provided a better rationale for ongoing dengue drug discovery. Though challenging, we are optimistic that this continuous, concerted effort will lead to an effective dengue therapy. PMID:24076358

  16. Reflections on Ten Years of the Commonwealth of Learning.

    ERIC Educational Resources Information Center

    Dhanarajan, Gajaraj

    This document reviews the 10-year history of the Commonwealth of Learning (COL), which is an intergovernmental organization that was created by Commonwealth of Nations heads of government to encourage the development and sharing of open learning and distance education knowledge, resources, and technologies. The following are among the topics…

  17. Ten years of anti-vascular endothelial growth factor therapy.

    PubMed

    Ferrara, Napoleone; Adamis, Anthony P

    2016-06-01

    The targeting of vascular endothelial growth factor A (VEGFA), a crucial regulator of both normal and pathological angiogenesis, has revealed innovative therapeutic approaches in oncology and ophthalmology. The first VEGFA inhibitor, bevacizumab, was approved by the US Food and Drug Administration in 2004 for the first-line treatment of metastatic colorectal cancer, and the first VEGFA inhibitors in ophthalmology, pegaptanib and ranibizumab, were approved in 2004 and 2006, respectively. To mark this tenth anniversary of anti-VEGFA therapy, we discuss the discovery of VEGFA, the successes and challenges in the development of VEGFA inhibitors and the impact of these agents on the treatment of cancers and ophthalmic diseases. PMID:26775688

  18. Ten years of tiotropium: clinical impact and patient perspectives

    PubMed Central

    Yohannes, Abebaw M; Connolly, Martin J; Hanania, Nicola A

    2013-01-01

    Tiotropium bromide is an anticholinergic agent that has gained worldwide acceptance as a first-line, once daily maintenance therapy for patients with moderate-to-severe chronic obstructive pulmonary disease. The purpose of this review is to synthesize the evidence base in the past 10 years on the development of tiotropium and its efficacy compared to other able interventions such as long-acting beta agonists (LABAs), as well as to assess its safety profile and its effects on health-related outcomes in patients with COPD. Treatment with tiotropium bromide has generally improved patients’ health-related quality of life, reduced the number of patients suffering from acute exacerbations, decreased the number of hospitalizations, improved dyspnea, and reduced adverse events compared to placebo. In the past decade, several studies have examined the safety and efficacy of tiotropium in comparison to placebo and to LABAs (salmeterol, formoterol, and indacaterol) over periods ranging from 3 months to 48 months of follow-up. Head-to-head comparisons of tiotropium 18 μg (once daily) with salmeterol 50 μg (twice daily) in well-controlled trials demonstrated that tiotropium was superior in reducing acute exacerbation events and in improving quality of life. In a few short-term studies, indacaterol was comparable to tiotropium in its efficacy in improving health-related outcomes. Although the safety record of tiotropium has been exemplary in comparison to placebo, anticholinergic events such as dry mouth can be encountered in some patients. While the long-term safety of tiotropium when delivered in the HandiHaler® has been well documented, its delivery using the Respimat® Soft Mist Inhaler™ was associated with an elevated risk of cardiovascular complications, including increased mortality when compared to placebo. The exact mechanism for this is not known but is being investigated in a large multinational study that will evaluate the long-term safety of different doses of tiotropium delivered by the Respimat® soft mist inhaler versus the HandiHaler®. Further studies are required to investigate the efficacy and safety of tiotropium in comparison with novel LABAs such as indacaterol and vilanterol, and with other emerging novel anticholinergic agents such as aclidinium bromide and NVA237 (glycopyrronium bromide). PMID:23515335

  19. The K-8 Principal in 1988: A Ten Year Study.

    ERIC Educational Resources Information Center

    Doud, James L.

    This 1988 survey of the elementary/middle school principalship is the sixth of its kind, with similar studies having been conducted in 1928, 1948, 1958, 1968 and 1978. The surveys provide an account of the factors that affect the status and characteristics of the K-8 principal. An 8-page instrument was mailed in the spring of 1987 to 2,414…

  20. Use of Interactive Lecture Demonstrations: A Ten Year Study

    ERIC Educational Resources Information Center

    Sharma, Manjula D.; Johnston, Ian D.; Johnston, Helen; Varvell, Kevin; Robertson, Gordon; Hopkins, Andrew; Stewart, Chris; Cooper, Ian; Thornton, Ronald

    2010-01-01

    The widely held constructivist view of learning advocates student engagement via interactivity. Within the physics education research community, several specific interactive strategies have been developed to enhance conceptual understanding. One such strategy, the Interactive Lecture Demonstration (ILD) is designed for large lecture classes and,…

  1. Collection overview: ten years of wonderful open access science.

    PubMed

    Roberts, Roland G; Alfred, Jane

    2013-10-01

    To mark our tenth Anniversary at PLOS Biology, we are launching a special, celebratory Tenth Anniversary PLOS Biology Collection which showcases 10 specially selected PLOS Biology research articles drawn from a decade of publishing excellent science. It also features newly commissioned articles, including thought-provoking pieces on the Open Access movement (past and present), on article-level metrics, and on the history of the Public Library of Science. Each research article highlighted in the collection is also accompanied by a PLOS Biologue blog post to extend the impact of these remarkable studies to the widest possible audience. PMID:24167446

  2. Ten Years of Silver Bullets: Dissenting Thoughts on Education Reform.

    ERIC Educational Resources Information Center

    Carpenter, Wade A.

    2000-01-01

    Countless good ideas, research, and reforms (silver bullets) have yielded only modest improvement, suggesting problems of research (dogma, design, duration, and domain) and problems of distribution--expanded teacher responsibility. This article recommends revamping teacher education, remediating or firing incompetent teachers, and reducing class…

  3. The Federal Advisory Committee Act after Ten Years.

    ERIC Educational Resources Information Center

    Keep, Paul M.

    Noting that there are more than 900 advisory committees providing private-sector advice to federal decision makers, this report investigates how well these committees have complied with the 1972 Federal Advisory Committee Act (FACA), which was intended to make them more accessible to the public and reporters. Following an overview of the subject,…

  4. Collection Overview: Ten Years of Wonderful Open Access Science

    PubMed Central

    Roberts, Roland G.; Alfred, Jane

    2013-01-01

    To mark our tenth Anniversary at PLOS Biology, we are launching a special, celebratory Tenth Anniversary PLOS Biology Collection which showcases 10 specially selected PLOS Biology research articles drawn from a decade of publishing excellent science. It also features newly commissioned articles, including thought-provoking pieces on the Open Access movement (past and present), on article-level metrics, and on the history of the Public Library of Science. Each research article highlighted in the collection is also accompanied by a PLOS Biologue blog post to extend the impact of these remarkable studies to the widest possible audience. PMID:24167446

  5. Trends Impacting Volunteer Administrators in the Next Ten Years.

    ERIC Educational Resources Information Center

    Culp, Ken, III; Nolan, Mike

    2000-01-01

    A survey of 49 volunteer leadership development programs (39% response) and 704 professional association members (46% response) identified the top volunteer trends: virtual volunteering, corporate/workplace volunteers, episodic volunteering, and changing demographics of volunteers. (JOW)

  6. Sunspot Numbers from ISOON: A Ten-Year Data Analysis

    NASA Astrophysics Data System (ADS)

    Balasubramaniam, K. S.; Henry, T. W.

    2016-03-01

    Sunspot numbers are important tracers of historical solar activity. They are important in predicting the oncoming solar maximum, in the design of lifetimes of space assets, and in assessing the extent of solar-radiation impact on the space environment. Historically, sunspot numbers have been obtained visually from sunspot drawings. The availability of digital images from the US Air Force Improved Solar Optical Observing Network (ISOON) prototype telescope concurrent to observer-dependent sunspot numbers recorded at the National Solar Observatory (NSO) has provided a basis for comparing sunspot numbers determined from the two methods. We compare sunspot numbers from visual and digital methods observed nearly simultaneously. The advantages of digital imagery are illustrated.

  7. Ten Years of Cloud Optical and Microphysical Retrievals from MODIS

    NASA Technical Reports Server (NTRS)

    Platnick, Steven; King, Michael D.; Wind, Galina; Hubanks, Paul; Arnold, G. Thomas; Amarasinghe, Nandana

    2010-01-01

    The MODIS cloud optical properties algorithm (MOD06/MYD06 for Terra and Aqua MODIS, respectively) has undergone extensive improvements and enhancements since the launch of Terra. These changes have included: improvements in the cloud thermodynamic phase algorithm; substantial changes in the ice cloud light scattering look up tables (LUTs); a clear-sky restoral algorithm for flagging heavy aerosol and sunglint; greatly improved spectral surface albedo maps, including the spectral albedo of snow by ecosystem; inclusion of pixel-level uncertainty estimates for cloud optical thickness, effective radius, and water path derived for three error sources that includes the sensitivity of the retrievals to solar and viewing geometries. To improve overall retrieval quality, we have also implemented cloud edge removal and partly cloudy detection (using MOD35 cloud mask 250m tests), added a supplementary cloud optical thickness and effective radius algorithm over snow and sea ice surfaces and over the ocean, which enables comparison with the "standard" 2.1 11m effective radius retrieval, and added a multi-layer cloud detection algorithm. We will discuss the status of the MOD06 algorithm and show examples of pixellevel (Level-2) cloud retrievals for selected data granules, as well as gridded (Level-3) statistics, notably monthly means and histograms (lD and 2D, with the latter giving correlations between cloud optical thickness and effective radius, and other cloud product pairs).

  8. Chandra: Ten Years of Amazing Science with a Great Observatory

    NASA Technical Reports Server (NTRS)

    Weisskopf, Martin C.

    2009-01-01

    We review briefly review the history of the development of the Chandra X-Ray Observatory, highlighting certain details that many attendees of this Conference might not be aware of. We then present a selection of scientific highlights of the first 10 years of this remarkable and unique mission.

  9. Ten Years of Excellence--Brochure Gets the Message Across.

    ERIC Educational Resources Information Center

    Whitten, Christine G.

    1986-01-01

    Although Roosevelt High School (Maryland) boasted an excellent science program and award-winning teachers, colleges in neighboring states were relatively ignorant about the school. In 1985 Roosevelt High's principal, with help from a special committee, developed a distinctive brochure to advertise the school's uniqueness. (MLH)

  10. [After ten years of AIDS, a vision emanating from feminism].

    PubMed

    Liguori, A L

    1991-01-01

    AIDS and the economic crisis in Mexico are threatening the epidemiologic transition in which infectious diseases ceased to be the only major cause of death and chronic degenerative diseases began to account for a growing proportion of deaths. Many factors combined to produce the sexual, gay, and women's liberation movements beginning in the 1970s. At the beginning of the feminist movement, women proposed different kinds of interpersonal relations both between women and with men. Women together realized their rights to control their own bodies, to sexual enjoyment, to abortion, and to free themselves of feelings of shame and guilt. The weight of moral pressures was lessened and the personal desires of the woman assumed a greater role in selection of sexual partners. Conservative forces grew stronger in the 1980s, and the proliferation of sexually transmitted diseases began to imperil the sexual revolution. But these setbacks were minor compared to AIDS. Now, 10 years after its appearance, it is clear that AIDS is not limited to homosexual men. The number of cases in Mexico increased from none 10 years ago to some 10,000 estimated cases reported and unreported today. 1/6 of the cases are in women. Many women and heterosexuals felt immune from AIDS in the beginning, and some still do, but many more have become aware of the danger. Women now fear contracting AIDS, but they also fear confronting their partners to suggest that they use condoms. Denial may play a role, but deeply rooted cultural factors that women may recognize but fee powerless to change may also be at play. Many women over 30 have difficulty taking the initiative in sexual matters. They are embarrassed to buy condoms and even more embarrassed to propose their use. They imagine that men will consider them "loose" if they carry condoms. Mexican women are poorly prepared to tell their men explicitly what they want sexually, and Mexican men are also poorly equipped to ask what women want, accustomed as they are to exercising sexuality exclusively to satisfy their own needs. The entire problem of condom use is related to ethical-moral and ideological factors and to broader attitudes toward knowledge. Those with more rational orientations see AIDS as a disease rather than a divine punishment and can more easily accept condom use as a preventive. PMID:12285214

  11. Ten Years down the Road: Predictors of Driving Cessation

    ERIC Educational Resources Information Center

    Edwards, Jerri D.; Bart, Edward; O'Connor, Melissa L.; Cissell, Gayla

    2010-01-01

    Purpose: Recent prospective studies have found that cognition is a more salient predictor of driving cessation than physical performance or demographic factors among community-dwelling older adults. However, these studies have been limited to 5 years of follow-up. The current study used data from the Maryland Older Drivers Project to examine…

  12. Ten Years On: Assessing Multimedia Distance-Learning.

    ERIC Educational Resources Information Center

    Vaillant-Sirdey, Christine

    This paper is a presentation of a 10-year experiment in multimedia distance learning in English for specific purposes within the general framework of a 3-year management diploma in the French higher education system. It defines, analyzes, and rationalizes key elements in the technical evolution against a background of epistemological and present…

  13. Laser Fusion: The First Ten Years 1962-1972

    SciTech Connect

    Kidder, R E

    2006-07-06

    This account of the beginning of the program on laser fusion at Livermore in 1962, and its subsequent development during the decade ending in 1972, was originally prepared as a contribution to the January 1991 symposium 'Achievements in Physics' honoring Professor Keith Brueckner upon his retirement from the University of San Diego at La Jolla. It is a personal recollection of work at Livermore from my vantage point as its scientific leader, and of events elsewhere that I thought significant. This period was one of rapid growth in which the technology of high-power short-pulse lasers needed to drive the implosion of thermonuclear fuel to the temperature and density needed for ignition was developed, and in which the physics of the interaction of intense light with plasmas was explored both theoretically and experimentally.

  14. Ten Years after Tiananmen: Some Unsung Heroes of the Struggle.

    ERIC Educational Resources Information Center

    American Educator, 1999

    1999-01-01

    Tells the life stories of some of the people who have worked for human rights and democracy in contemporary China. Five profiles show the obstacles faced by Chinese teachers in the human-rights struggle. (SLD)

  15. Ten-years experience of laser use in aesthetic surgery

    NASA Astrophysics Data System (ADS)

    Gulev, Valerii S.; Dobrjakova, Olga B.; Dobrjakov, Boris S.

    2001-10-01

    A collaboration of the laser physicist and aesthetic surgeons has started 10 years ago. Within the period 1992 - 2000 we have carried out the investigation of the influence of the pulsed radiation, emitted by lasers having as active mediums crystals of the aluminum-yttrium garnet and alexandrite, on the cultures of the alive tissue and the fibrosis capsules around foreign bodies in the animals. Besides, we have studied the clinical protocol: in majority, patients were women after mammary augmentation. The laser tatoo non-invasive removals were marked at the beginning of the pulse of the Q-switch neodymium yttrium-aluminum garnet laser radiation used in human. It was obtained that this laser radiation broke the cell proliferation without any mutations and morphology changes. It was also noticed much evidence that the high functional fibroblast activities were registered in fibrosis capsules of not exposed animals to the laser radiation. It was also noticed that the use of laser radiation affected the speed and quality of the productive inflammation. The softening of the fibrous capsule around the mammary implant and the reduction of the pronounced rubbers were the clinical effects of the laser radiation.

  16. The Mission of the Registrar: A Ten-Year Retrospective

    ERIC Educational Resources Information Center

    Lanier, David C.

    2006-01-01

    Records management, database management, and business process management--what do they have to do with the mission of the registrar? This article takes a look at how well the 1995 article, "The Mission of the Registrar Today," did in predicting the direction of the registrar's profession and makes some new predictions about future responsibilities…

  17. Ten Years of Cybertech: The Educational Benefits of Bullfighting Robotics

    ERIC Educational Resources Information Center

    Hernando, M.; Galan, R.; Navarro, I.; Rodriguez-Losada, D.

    2011-01-01

    After 10 years of organizing the Cybertech robotics competition, this paper presents this unique and innovative educational experience of teaching engineering at Universidad Politecnica de Madrid (UPM), Spain. Cybertech is not only a well-known robotic contest in Spain due to the "Robotaurus" bullfighting, but is also a whole academic activity…

  18. A Report on a Ten Year Old Public University

    ERIC Educational Resources Information Center

    Cordeiro, William P.; Muraoka, Dennis

    2014-01-01

    California State University Channel Islands (CI) was founded in 2001 (in Camarillo, CA) and admitted its first students in 2002. Over the ensuing decade, the campus has transitioned from a start-up institution to a regionally accredited comprehensive university offering 23 baccalaureate and 6 graduate degree programs. This transition has occurred…

  19. Embryo stem cell research: ten years of controversy.

    PubMed

    Robertson, John A

    2010-01-01

    This overview of 10 years of stem cell controversy reviews the moral conflict that has made ESCs so controversial and how this conflict plays itself out in the legal realm, focusing on the constitutional status of efforts to ban ESC research or ESC-derived therapies. It provides a history of the federal funding debate from the Carter to the Obama administrations, and the importance of the Raab memo in authorizing federal funding for research with privately derived ESCs despite the Dickey-Wicker ban on federal funding of embryo research. It also reviews the role that scientists themselves have played in developing regulations for ESC research, the emergence of ESCROs as special review bodies for ESC research, and the thorough consent requirements for donation of IVF embryos to ESC research. With research now transitioning from the lab to the clinic, the article reviews the challenges of ensuring safety and consent in translational research. It concludes with a call for respecting those persons who have to using or working with ESC products and an account of how obtaining stem cells from a person's own cells will alleviate some but not all of the controversy surrounding ESC research. PMID:20579242

  20. Reculturing Educational Leadership: The ISLLC Standards Ten Years Out.

    ERIC Educational Resources Information Center

    Murphy, Joseph

    Over the last 25 years, the field of school administration has experienced turmoil as it has struggled to grow out of its adolescence. A good deal of energy has been invested in coming to grips with the question of what ideas should shape school administration. This paper chronicles the role of one of the most significant reshaping initiatives to…

  1. Ten years of Developing International Volcanology Graduate Study Programs

    NASA Astrophysics Data System (ADS)

    Rose, W. I.

    2010-12-01

    In 2000 I reported at this symposium about multi-institutional graduate field trips to IAVCEI events, such as the Bali meeting and its importance in building international collegiality and awareness among the volcanology doctoral students. NSF was an enthusiastic supporter of these field sessions and this support has continued through the highly successful Pucon and Reykjavik sessions. International volcanology graduate program development began with several exchange programs. EHaz was a highly successful program (McGill, Simon Fraser, Michigan Tech, Buffalo, UNAM and Universidad de Colima) funded by the Department of Education (FIPSE) that moved students across North America where dozens of graduate students spent semesters of their study abroad and shared annual field trips and online student led graduate seminar classes. Michigan Tech’s volcanology graduate program started a Masters International program that combined Peace Corps service with hazards mitigation graduate study and students were placed by Peace Corps in countries with prominent natural hazards. The new program funded 2 year residences in foreign environments, principally in Pacific Latin America. NSF strongly supported this program from its inception, and eventually it gained NSF PIRE support. Dozens of students have initiated the 3 year program (15 completed) to date. A similar PIRE developed at UAF with a link to volcanology in the Russian Far East. One gain is the development of many socially-conscious research selections. Beginning this year transatlantic dual degree masters programs in volcanology are being offered by a consortium of US and European volcanology programs (Michigan Tech, Buffalo, Clermont Ferrand and University of Milan Bicocca), again aided by FIPSE funding. Students have dual advisors on both sides of the Atlantic and spend about half of their two year programs in Europe and half in US. Faculty also travel in the program and the four campuses are increasingly linked by coursework and research networks. Because the international developments of volcanology programs address the need for more robust coursework and research choices for students than are possible on one campus, and because they lead to a diverse network of professional contacts , we think the next decade will bring many more multi-university volcanology programs linked to field sites all over the world.

  2. Methadone-related deaths. A ten year overview.

    PubMed

    Vignali, Claudia; Stramesi, Cristiana; Morini, Luca; Pozzi, Fulvia; Groppi, Angelo

    2015-12-01

    Over the last 10 years we have registered in our district (about 500,000 inhabitants) 36 cases of fatal methadone poisoning, involving both patients on treatment and naive subjects: this is a significant increase of deaths due to methadone use, misuse or abuse compared with previous years. Twenty-four patients (66.7%) were on methadone maintenance programs for heroin detoxification, while 12 (33.3%) were taking the drug without a medical prescription. The average blood concentration of methadone in patients undergoing a maintenance program was 1.06 mg/L (0.21-3.37 mg/L), against 0.79 mg/L (0.2-3.15 mg/L) in those taking the non-prescribed drug. Since 111 heroin-related deaths were recorded in our district in the same period, the fact that there appear to be many methadone deaths (about a third of heroin-related deaths) cannot be overlooked. The aim of this work is to understand the possible reasons for such a large number of methadone-related deaths. On this subject, we have noticed that risks associated with methadone intake are often underestimated by clinicians prescribing the drug: sometimes methadone is prescribed without taking into account patient's tolerance to opiates, and a large number of subjects enrolled in methadone maintenance programs in Italy, have also been given take-home doses, thus increasing the risk of abuse and diversion. PMID:26360592

  3. Raccoon Mountain pumped-storage plant: Ten years operating experience

    SciTech Connect

    Adkins, F.E.

    1987-09-01

    Operational experience at the 1 530 MW Raccoon Mountain underground pumped-storage plant can be relevant to other large hydro facilities. A number of unusual features were incorporated and individual unit size was only recently overtaken elsewhere. Direct water cooling of rotor and stator winding has been successfully applied to salient pole machines. A number of problems, including difficulties with oil-filled 161 kV current transformers, and some mechanical aspects, are reported. Designed for remote supervisory control, the plant has required closer attention. Operating statistics are included.

  4. Lessons from Ten Years of TEAC's Accrediting Activity

    ERIC Educational Resources Information Center

    Murray, Frank B.

    2010-01-01

    Founded in 1997, the Teacher Education Accreditation Council (TEAC) designed a system that balances three sources of evidence in a single accreditation system: (1) that the program's graduates are qualified, competent, and caring beginning teachers; (2) that the program faculty investigates the factors that improve program quality; and (3) that…

  5. Ten Years of Shock Tube Research at Marseille

    NASA Astrophysics Data System (ADS)

    Houas, L.

    The invention of the shock tube is attributed to Paul Vieille [1] in the late 19th century. The first simplest shock tube was composed of two chambers separated by a diaphragm.With the pressure increase in the first chamber causing the diaphragm rupture, a shock wave was generated and propagated with a supersonic velocity in the second chamber.

  6. Ten Years of Demographics: Who Debates in America.

    ERIC Educational Resources Information Center

    Stepp, Pamela L.; Gardner, Beth

    2001-01-01

    Presents demographics about gender and ethnicity of debate directors, debate coaches, and debaters in the Cross Examination Debate Association's National Tournament from 1991-2000. Considers that although there has been an increase in the numbers of females and minorities debating, there has also been a decline in the numbers of females directing…

  7. Ten years of quests for radio bursts from extrasolar planets

    NASA Astrophysics Data System (ADS)

    Shiratori, Y.; Yokoo, H.; Saso, T.; Kameya, O.; Iwadate, K.; Asari, K.

    2006-02-01

    We searched for radio bursts towards 51 Peg, τ Boo, ν And and 55 Cancri, which were found to have "hot Jupiter" companions. The star 51 Peg has a planet with 0.5 M_{Jup} (lower limit) and 4.23 day period. The star τ Boo has a planet of 3.7 M_{Jup} and 3.31 day period. Such planets are called "Hot Jupiter". We made a non-thermal radio emission model of magneto-electric environment between the stars and their planets. Since a detection of signals is expected, we made observations at 8.6 GHz with Mizusawa 10-m telescope. From 1996 to 2000, we observed with a detection limit of 10 Jy using a position-switching method. Since 2001, we changed to beam-switching method, and achieved a detection limit of 1 Jy. No radio burst signals were detected.

  8. The medicine and public health initiative ten years later.

    PubMed

    Beitsch, Leslie M; Brooks, Robert G; Glasser, Jay H; Coble, Yank D

    2005-08-01

    The Medicine and Public Health Initiative (MPHI) was created jointly 10 years ago by the American Medical Association and the American Public Health Association to bridge the nearly century-wide gulf between the respective disciplines. We review the history of MPHI and its growing significance in light of recent terrorism events. We report on current MPHI activities by examining three bellwether states-California, Florida, and Texas-as well as international sites. Upon its inception, MPHI was rapidly embraced and nationally disseminated. Sustainability 10 years later in the post-911 world requires renewed commitment by all collaborators. In order to meet the numerous health challenges facing our nation, from terrorism to chronic disease, and for MPHI to be successful, medicine and public health must work in tandem. PMID:16005812

  9. Ten years of ice hockey-related-injuries in the German Ice Hockey Federation - A Ten Year Prospective Study/523 International Games -.

    PubMed

    Gröger, A

    2001-12-01

    Since January 1986 all injuries in players of the German national hockey teams (juniors A/B and seniors A/B), which have occurred during international competitions, have been registrated and evaluated by using a strict definition of injury, standardized reporting strategies and diagnosis by the team physician. Patterns of injury have been identified and correlations between position, zone and cause of injury could be analysed and, as a consequence, measures were taken to prevent them. A total of 147 injuries forcing a consecutive absence from the game during 523 international games of the German national teams were reported. During the 10 year period there was a marked decrease of the total number and incidence of injuries. In addition, injury rate and average absence from game time improved. There were more frequent concussions of the brain but the total number of facial injuries dropped after the introduction of a visor and the full face mask especially in junior hockey. The forward was the position most at risk to be injured and most injuries were caused by players contact. PMID:11753779

  10. [Long-term results of surgical treatment of lumbar disk herniation in adults].

    PubMed

    Dudek, H; Michno, T; Łebkowski, W J; Kozłowski, A

    2001-01-01

    The authors present long-term results (10.2 years post-op) of surgical treatment of lumbar disc herniation in 1003 patients operated at the Department of Neurosurgery by the University of Medical Sciences in Białystok. The operated group comprised 33.1% women (mean age--55.6 years) and 68.7% men (mean age 57.3 years). Ten years post-op 15.9% women and 5.8% men kept the recommended diet, 14% women and 7.0% men continued muscle strengthening exercise. Ten years post-op excellent and good results were noted in respectively 42.4% and 46.5% women and 45.4% and 46.6% men. PMID:11761755

  11. The Status of Mathematics Achievement in Two Elementary Schools in Palau: 1984-1990. A Report to the Ministry of Education.

    ERIC Educational Resources Information Center

    King, Irvin L.; Emesiochl, Masa-Aki

    When the Trust Territory of the Pacific Islands gradually dissolved in the 1980s, the Republic of Palau assumed a greater responsibility for its own education system. In order to monitor the mathematical achievement of elementary school students during the transition from external to local control of educational procedures, basic skills…

  12. Ten years of science in Philosophical Transactions A: with the University Research Fellows.

    PubMed

    Thompson, J Michael T

    2007-12-15

    In this brief paper, I review my 10 years as the Editor of the Philosophical Transactions of the Royal Society A. I look at the content of the journal over the years, relating it to a full classification of the physical sciences based on the interests of fellows and research fellows of the Royal Society. I show that the journal has performed well in terms of downloads, citations and impact factors. Innovations such as the Millennium and Christmas Issues for young scientists have stimulated a close and enjoyable interaction with the Society's research fellows. In addition to authoring papers and organizing themes, they have always been keen to help with the refereeing processes. They provided exciting demonstrations for a Summer Science exhibit that I organized to highlight the work of the journal, and five of the research fellows now sit on the Editorial Board. Looking to the future, I describe the new subject clusters that are being introduced as the journal steps up its publication rate from one issue per month to two, starting in January 2008. PMID:17855215

  13. Ten Years of External Quality Audit in Australia: Evaluating Its Effectiveness and Success

    ERIC Educational Resources Information Center

    Shah, Mahsood

    2012-01-01

    External quality audits are now being used in universities across the world to improve quality assurance, accountability for quality education and transparency of public funding of higher education. Some countries such as Australia, New Zealand, United Kingdom, Sweden and Denmark have had external quality audits for more than a decade but there…

  14. Producing Bulk Ultrafine-Grained Materials by Severe Plastic Deformation: Ten Years Later

    NASA Astrophysics Data System (ADS)

    Valiev, Ruslan Z.; Estrin, Yuri; Horita, Zenji; Langdon, Terence G.; Zehetbauer, Michael J.; Zhu, Yuntian

    2016-04-01

    It is now well established that the processing of bulk solids through the application of severe plastic deformation (SPD) leads to exceptional grain refinement to the submicrometer or nanometer level. Extensive research over the last decade has demonstrated that SPD processing also produces unusual phase transformations and leads to the introduction of a range of nanostructural features, including nonequilibrium grain boundaries, deformation twins, dislocation substructures, vacancy agglomerates, and solute segregation and clustering. These many structural changes provide new opportunities for fine tuning the characteristics of SPD metals to attain major improvements in their physical, mechanical, chemical, and functional properties. This review provides a summary of some of these recent developments. Special emphasis is placed on the use of SPD processing in achieving increased electrical conductivity, superconductivity, and thermoelectricity, an improved hydrogen storage capability, materials for use in biomedical applications, and the fabrication of high-strength metal-matrix nanocomposites.

  15. Environmental monitoring of Space Shuttle launches at Kennedy Space Center - The first ten years

    NASA Technical Reports Server (NTRS)

    Schmalzer, Paul A.; Hall, Carlton R.; Hinkle, C. R.; Duncan, Brean W.; Knott, William M., III; Summerfield, Burton R.

    1993-01-01

    Space Shuttle launches produce local environmental effects through the generation of a launcher exhaust plume that in turn produces acidic depositions and acute vegetation damage in the near-field environment; fish kills have also been noted in the lagoon or impoundment near each of the launch pads. Repeated launches lead to cumulative changes in plant community composition and structure, and temporary decreases in pH due to acidification increases metal availability in soil microcosms and surface waters. Direct effects on terrestrial fauna include the mortality of birds, mammals, amphibians, and reptiles in the near-field area.

  16. Female Participation in ATE-Funded Programs: A Ten-Year Trend

    ERIC Educational Resources Information Center

    Westine, Carl D.; Gullickson, Arlen R.; Wingate, Lori A.

    2010-01-01

    It is widely known that women are generally underrepresented in STEM disciplines (science, technology, engineering, and mathematics). The National Science Foundation (NSF) Advanced Technological Education (ATE) program has persistently worked to reduce this disparity. For example, the 2000 solicitation specified "increasing the participation of…

  17. And We Are Still Not Saved: Critical Race Theory in Education Ten Years Later

    ERIC Educational Resources Information Center

    Dixson, Adrienne D.; Rousseau, Celia K.

    2005-01-01

    In 1995, Teachers College Record published an article by Gloria Ladson-Billings and William Tate entitled "Toward a Critical Race Theory of Education". In this article, the authors proposed that critical race theory (CRT), a framework developed by legal scholars, could be employed to examine the role of race and racism in education. Within a few…

  18. Radiation therapy of penile cancer: six to ten-year follow-up

    SciTech Connect

    Grabstald, H.; Kelley, C.D.

    1980-06-01

    Ten patients with penile cancer were treated with radiation therapy between 1968 and 1973. Nine of ten remain free of disease though in 1 patient a new penile primary developed eight years after the radiation therapy and was treated by partial penectomy. One patient died following surgery for ''bleeding ulcer.'' He was free of penile cancer five years after radiation. The most common complication is urethral stricture and skin telangiectasia.

  19. Generation IV Nuclear Energy Systems Ten-Year Program Plan Fiscal Year 2005, Volume 1

    SciTech Connect

    2005-03-01

    As reflected in the U.S. ''National Energy Policy'', nuclear energy has a strong role to play in satisfying our nation's future energy security and environmental quality needs. The desirable environmental, economic, and sustainability attributes of nuclear energy give it a cornerstone position, not only in the U.S. energy portfolio, but also in the world's future energy portfolio. Accordingly, on September 20, 2002, U.S. Energy Secretary Spencer Abraham announced that, ''The United States and nine other countries have agreed to develop six Generation IV nuclear energy concepts''. The Secretary also noted that the systems are expected to ''represent significant advances in economics, safety, reliability, proliferation resistance, and waste minimization''. The six systems and their broad, worldwide research and development (R&D) needs are described in ''A Technology Roadmap for Generation IV Nuclear Energy Systems'' (hereafter referred to as the Generation IV Roadmap). The first 10 years of required U.S. R&D contributions to achieve the goals described in the Generation IV Roadmap are outlined in this Program Plan.

  20. The Spiral of Silence Ten Years Later: An Examination and Evaluation.

    ERIC Educational Resources Information Center

    Salmon, Charles T.; Kline, F. Gerald

    In her model of opinion formation, Elizabeth Noelle-Neumann postulates a spiral of silence: to avoid isolation, people holding minority views either alter their ideas to conform to the majority's stance or remain silent, thus increasing the impression of the majority view's dominance. While providing a helpful integration of disparate ideas in…