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Sample records for 1a parte calidad

  1. Quality planning, part 1: a holistic and practical approach.

    PubMed

    Odegard, Russell D

    2013-01-01

    This article is the first in a two-part series that breaks down quality planning into a systematic, stepwise process. Part 1 addresses the tangible aspects of compounding that directly influence the quality of compounded preparations. Part 2 will speak to less tangible but critically important mechanisms targeting continuous improvement. The author takes a holistic approach, which he describes as a comprehensive, systematic, and proactive approach to continuously improve everything that may, directly or indirectly, influence the quality of a preparation or service. PMID:24459786

  2. The pin-amalgam restoration. Part 1. A review.

    PubMed

    Evans, J R; Wetz, J H

    1977-01-01

    A review of the literature indicates that the use of pins to support amalgam or cast gold restorations in advanced caries in posterior teeth is a quick and relatively inexpensive method of restoring teeth otherwise doomed to extraction. However, the use of pins demands a careful and skillful dentist who understands the morphology of these teeth and the proper use of the materials if injury to the pulp, accidental perforations, crazing of the dentin, and splitting of teeth are to be prevented. Until more objective and controlled studies are completed, the use of cemented pins vs. self-threading pins remains a matter of empirical and personal preference. It is clear that success in the use of any pin or pins depends more on the dentist's skill and judgment than on the particular type of pin technique used. In order to more objectively evaluate the use of pin-amalgam restorations, Part 11 of this study will analyze the results obtained in the Clinic at Tufts University School of Dental Medicine. PMID:318695

  3. 40 CFR Table 1a to Subpart G of... - Applicable 40 CFR Part 63 General Provisions

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    .... 63, Subpt. G, Table 1A Table 1A to Subpart G of Part 63—Applicable 40 CFR Part 63 General Provisions 40 CFR part 63, subpart A, provisions applicable to subpart G § 63.1(a)(1), (a)(2), (a)(3), (a)(13... 40 Protection of Environment 9 2010-07-01 2010-07-01 false Applicable 40 CFR Part 63...

  4. 50 CFR Table 1a to Part 679 - Delivery Condition* and Product Codes

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false Delivery Condition* and Product Codes 1a Table 1a to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OF THE EXCLUSIVE ECONOMIC ZONE OFF ALASKA Pt. 679, Table 1a Table 1a...

  5. 19 CFR Appendix to Part 163 - Interim (a)(1)(A) List

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Interim (a)(1)(A) List Appendix to Part 163 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) RECORDKEEPING Pt. 163, App. Appendix to Part 163—Interim (a)(1)(A) List List of Records Required for the Entry of Merchandise...

  6. Culture and Literacy. Part 1: A Historic Overview. Part 2: The Needs of a Pluralistic Society. Part 3: Student Perceptions.

    ERIC Educational Resources Information Center

    Masters, Billie Nave

    This three-part series of articles discusses restructuring U.S. public education to meet the needs of culturally diverse student populations. Part 1 presents a historic overview of the philosophies and attitudes underlying delivery of U.S. public education. The American school system is slow to change and, for the benefit of the industrialized…

  7. 50 CFR Table 1a to Part 679 - Delivery Condition* and Product Codes

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 13 2012-10-01 2012-10-01 false Delivery Condition* and Product Codes 1a Table 1a to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OF THE EXCLUSIVE ECONOMIC ZONE...

  8. 50 CFR Table 1a to Part 679 - Delivery Condition* and Product Codes

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 11 2011-10-01 2011-10-01 false Delivery Condition* and Product Codes 1a Table 1a to Part 679 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES OF THE EXCLUSIVE ECONOMIC ZONE...

  9. Mitochondrial Carnitine Palmitoyltransferase 1a (CPT1a) Is Part of an Outer Membrane Fatty Acid Transfer Complex*

    PubMed Central

    Lee, Kwangwon; Kerner, Janos; Hoppel, Charles L.

    2011-01-01

    CPT1a (carnitine palmitoyltransferase 1a) in the liver mitochondrial outer membrane (MOM) catalyzes the primary regulated step in overall mitochondrial fatty acid oxidation. It has been suggested that the fundamental unit of CPT1a exists as a trimer, which, under native conditions, could form a dimer of the trimers, creating a hexamer channel for acylcarnitine translocation. To examine the state of CPT1a in the MOM, we employed a combined approach of sizing by mass and isolation using an immunological method. Blue native electrophoresis followed by detection with immunoblotting and mass spectrometry identified large molecular mass complexes that contained not only CPT1a but also long chain acyl-CoA synthetase (ACSL) and the voltage-dependent anion channel (VDAC). Immunoprecipitation with antisera against the proteins revealed a strong interaction between the three proteins. Immobilized CPT1a-specific antibodies immunocaptured not only CPT1a but also ACSL and VDAC, further strengthening findings with blue native electrophoresis and immunoprecipitation. This study shows strong protein-protein interaction between CPT1a, ACSL, and VDAC. We propose that this complex transfers activated fatty acids through the MOM. PMID:21622568

  10. Mitochondrial carnitine palmitoyltransferase 1a (CPT1a) is part of an outer membrane fatty acid transfer complex.

    PubMed

    Lee, Kwangwon; Kerner, Janos; Hoppel, Charles L

    2011-07-22

    CPT1a (carnitine palmitoyltransferase 1a) in the liver mitochondrial outer membrane (MOM) catalyzes the primary regulated step in overall mitochondrial fatty acid oxidation. It has been suggested that the fundamental unit of CPT1a exists as a trimer, which, under native conditions, could form a dimer of the trimers, creating a hexamer channel for acylcarnitine translocation. To examine the state of CPT1a in the MOM, we employed a combined approach of sizing by mass and isolation using an immunological method. Blue native electrophoresis followed by detection with immunoblotting and mass spectrometry identified large molecular mass complexes that contained not only CPT1a but also long chain acyl-CoA synthetase (ACSL) and the voltage-dependent anion channel (VDAC). Immunoprecipitation with antisera against the proteins revealed a strong interaction between the three proteins. Immobilized CPT1a-specific antibodies immunocaptured not only CPT1a but also ACSL and VDAC, further strengthening findings with blue native electrophoresis and immunoprecipitation. This study shows strong protein-protein interaction between CPT1a, ACSL, and VDAC. We propose that this complex transfers activated fatty acids through the MOM. PMID:21622568

  11. Phase-ambiguity resolution for QPSK modulation systems. Part 1: A review

    NASA Technical Reports Server (NTRS)

    Nguyen, Tien Manh

    1989-01-01

    Part 1 reviews the current phase-ambiguity resolution techniques for QPSK coherent modulation systems. Here, those known and published methods of resolving phase ambiguity for QPSK with and without Forward-Error-Correcting (FEC) are discussed. The necessary background is provided for a complete understanding of the second part where a new technique will be discussed. An appropriate technique to the Consultative Committee for Space Data Systems (CCSDS) is recommended for consideration in future standards on phase-ambiguity resolution for QPSK coherent modulation systems.

  12. 19 CFR Appendix to Part 163 - Interim (a)(1)(A) List

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... merchandise entered in accordance with the provisions of the sections of 19 CFR listed). These are in addition... and relief equipment 15 CFR part 301Requirements for entry of scientific and educational apparatus... direct shipment § 10.179Certificate of importer of crude petroleum § 10.180Certificate of fresh,...

  13. 19 CFR Appendix to Part 163 - Interim (a)(1)(A) List

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... merchandise entered in accordance with the provisions of the sections of 19 CFR listed). These are in addition... preferential tariff treatment, including an importer's certification 15 CFR part 301Requirements for entry of... importer of crude petroleum § 10.180Certificate of fresh, chilled or frozen beef § 10.183Civil...

  14. 19 CFR Appendix to Part 163 - Interim (a)(1)(A) List

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... merchandise entered in accordance with the provisions of the sections of 19 CFR listed). These are in addition... preferential tariff treatment, including an importer's certification 15 CFR part 301Requirements for entry of... importer of crude petroleum § 10.180Certificate of fresh, chilled or frozen beef § 10.183Civil...

  15. 19 CFR Appendix to Part 163 - Interim (a)(1)(A) List

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... merchandise entered in accordance with the provisions of the sections of 19 CFR listed). These are in addition... preferential tariff treatment, including an importer's certification 15 CFR part 301Requirements for entry of... importer of crude petroleum § 10.180Certificate of fresh, chilled or frozen beef § 10.183Civil...

  16. 50 CFR Table 1a to Part 679 - Delivery Condition and Product Codes

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (includes offsite production).DO NOT RECORD ON PTR. 42 Bones (if meal, report as 32) (ancillary only). 39... body behind head and in front of tail. 21 Fish meal. Meal from whole fish or fish parts; includes bone..., Western cut.Head removed just in front of the collar bone, and viscera removed. 07 Headed and...

  17. Plant-based medicines for anxiety disorders, Part 1: a review of preclinical studies.

    PubMed

    Sarris, Jerome; McIntyre, Erica; Camfield, David A

    2013-03-01

    Research in the area of herbal psychopharmacology has revealed a variety of promising medicines that may provide benefit in the treatment of general anxiety and specific anxiety disorders. However, a comprehensive review of plant-based anxiolytics has been absent to date. This article (part 1) reviews herbal medicines for which only preclinical investigations for anxiolytic activity have been performed. In part 2, we review herbal medicines for which there have been clinical investigations for anxiolytic activity. An open-ended, language-restricted (English) search of MEDLINE (PubMed), CINAHL, Scopus and the Cochrane Library databases was conducted (up to 28 October 2012) using specific search criteria to identify herbal medicines that have been investigated for anxiolytic activity. This search of the literature revealed 1,525 papers, from which 53 herbal medicines were included in the full review (having at least one study using the whole plant extract). Of these plants, 21 had human clinical trial evidence (reviewed in part 2), with another 32 having solely preclinical studies (reviewed here in part 1). Preclinical evidence of anxiolytic activity (without human clinical trials) was found for Albizia julibrissin, Sonchus oleraceus, Uncaria rhynchophylla, Stachys lavandulifolia, Cecropia glazioui, Magnolia spp., Eschscholzia californica, Erythrina spp., Annona spp., Rubus brasiliensis, Apocynum venetum, Nauclea latifolia, Equisetum arvense, Tilia spp., Securidaca longepedunculata, Achillea millefolium, Leea indica, Juncus effusus, Coriandrum sativum, Eurycoma longifolia, Turnera diffusa, Euphorbia hirta, Justicia spp., Crocus sativus, Aloysia polystachya, Albies pindrow, Casimiroa edulis, Davilla rugosa, Gastrodia elata, Sphaerathus indicus, Zizyphus jujuba and Panax ginseng. Common mechanisms of action for the majority of botanicals reviewed primarily involve GABA, either via direct receptor binding or ionic channel or cell membrane modulation; GABA transaminase

  18. Long-term athletic development- part 1: a pathway for all youth.

    PubMed

    Lloyd, Rhodri S; Oliver, Jon L; Faigenbaum, Avery D; Howard, Rick; De Ste Croix, Mark B A; Williams, Craig A; Best, Thomas M; Alvar, Brent A; Micheli, Lyle J; Thomas, D Phillip; Hatfield, Disa L; Cronin, John B; Myer, Gregory D

    2015-05-01

    The concept of developing talent and athleticism in youth is the goal of many coaches and sports systems. Consequently, an increasing number of sporting organizations have adopted long-term athletic development models in an attempt to provide a structured approach to the training of youth. It is clear that maximizing sporting talent is an important goal of long-term athletic development models. However, ensuring that youth of all ages and abilities are provided with a strategic plan for the development of their health and physical fitness is also important to maximize physical activity participation rates, reduce the risk of sport- and activity-related injury, and to ensure long-term health and well-being. Critical reviews of independent models of long-term athletic development are already present within the literature; however, to the best of our knowledge, a comprehensive examination and review of the most prominent models does not exist. Additionally, considerations of modern day issues that may impact on the success of any long-term athletic development model are lacking, as are proposed solutions to address such issues. Therefore, within this 2-part commentary, Part 1 provides a critical review of existing models of practice for long-term athletic development and introduces a composite youth development model that includes the integration of talent, psychosocial and physical development across maturation. Part 2 identifies limiting factors that may restrict the success of such models and offers potential solutions. PMID:25486295

  19. What's law got to do with it part 1: A framework for obesity prevention

    PubMed Central

    Magnusson, Roger S

    2008-01-01

    This article provides a conceptual framework for thinking about the role of law in responding to population weight gain in Australia. Part 1 focuses on two core questions. Firstly, in pursuing the aim of weight reduction at the population level, what should law be trying to influence? The challenge here is to identify a model of the determinants of obesity that is adequate for legal purposes and that illustrates the entry points where law could best be used as an instrument of public health policy. Secondly, what kinds of strategies and tools can law offer to obesity prevention? The challenge here is to identify a model of law that captures the variety of contributions law is capable of making, at different levels of government, and across different legal systems. In Part 1 of the article, I argue that although law can intervene at a number of levels, the most important opportunities lie in seeking to influence the social, economic and environmental influences that shape patterns of eating and nutrition across the population as a whole. Only policies that impact broadly across the population can be expected to influence the weight distribution curve that has shifted relentlessly to the right in recent decades. Part 2 of the article builds on this analysis by offering a critical review of selected legal strategies for healthier nutrition and obesity prevention. PMID:18533998

  20. Eigen analysis of tree-ring records: Part 1, a limited representativeness of regional curve

    NASA Astrophysics Data System (ADS)

    Yang, Bao; Sonechkin, Dmitry M.; Datsenko, Nina M.; Ivashchenko, Nadezda N.; Liu, Jingjing; Qin, Chun

    2011-12-01

    Based on a set of very long-living (2,000 years) Qilian junipers ( Sabina przewalskii Kom.) from the north-eastern part of the Tibetan Plateau (the region of Dulan), we carefully consider the regional curve standardization (RCS) technique. For this goal, we correlate deviations of individual tree-ring width records from their regional mean age-dependent curve (RC). It turns out that these correlations keep their positivity for almost all shifts between ages compared (up to 500 years and even more) evidencing each Dulan juniper to be a unique "thermometer". Just the unification of these "thermometers" in the form RC creates a spurious positive trend in the Dulan chronology. We modify the RCS technique to closer attach RC to these "thermometers" in order to construct a new chronology in which the trend is absent.

  1. Psychiatry training in the United Kingdom--Part 1: a general overview.

    PubMed

    Kasiakogia, K; Christodoulou, N

    2014-01-01

    In recent years there has been a strong trend of emigration of Greek medical doctors. The reason for this phenomenon is certainly multifactorial, but it has been greatly exacerbated due to the latest financial crisis. The United Kingdom is one of the most popular destinations amongst emigrating Greek psychiatric doctors, as reflected by official data and by the sheer volume of requests for information received by the United Kingdom Division of the Hellenic Psychiatric Association. There are many systemic and practical differences between the Greek and the United Kingdom health systems, which complicate training and further career decisions. These complex differences make it hard for psychiatric doctors to decide which steps to take, and often result in them making the "wrong" decision. These "wrong" decisions are very often the result of poor information or misinformation. For instance many doctors are confused about the equivalence of training and service grades between Greece and the United Kingdom, what a good portfolio means, or the significance of the MRCPsych exam. This information exists, sometimes in comprehensive ways on the internet, but for doctors who are not familiar with the system, finding this information can be a time-consuming and laborious task. Therefore, providing a starting point with realistic and useful information about psychiatric training and generally career progression in the United Kingdom to Greek psychiatric doctors has become very important. The United Kingdom Division of the Hellenic Psychiatric Association has decided to pick up the role of providing exactly that information. The first part of this two-piece paper provides a starting point for Greek doctors considering the move to the United Kingdom for training and/or work in psychiatry. Firstly, it gives a general overview of psychiatric training in the United Kingdom, and explains that the pragmatic equivalence between training stages between Greece and the United Kingdom often

  2. Steady induction effects in geomagnetism. Part 1A: Steady motional induction of geomagnetic chaos

    NASA Technical Reports Server (NTRS)

    Voorhies, Coerte V.

    1992-01-01

    Geomagnetic effects of magnetic induction by hypothetically steady fluid motion and steady magnetic flux diffusion near the top of Earth's core are investigated using electromagnetic theory, simple magnetic earth models, and numerical experiments with geomagnetic field models. The problem of estimating a steady fluid velocity field near the top of Earth's core which induces the secular variation indicated by broad-scale models of the observed geomagnetic field is examined and solved. In Part 1, the steady surficial core flow estimation problem is solved in the context of the source-free mantle/frozen-flux core model. In the first paper (IA), the theory underlying such estimates is reviewed and some consequences of various kinematic and dynamic flow hypotheses are derived. For a frozen-flux core, fluid downwelling is required to change the mean square normal magnetic flux density averaged over the core-mantle boundary. For surficially geostrophic flow, downwelling implies poleward flow. The solution of the forward steady motional induction problem at the surface of a frozen-flux core is derived and found to be a fine, easily visualized example of deterministic chaos. Geomagnetic effects of statistically steady core surface flow may well dominate secular variation over several decades. Indeed, effects of persistent, if not steady, surficially geostrophic core flow are described which may help explain certain features of the present broad-scale geomagnetic field and perhaps paleomagnetic secular variation.

  3. A simplified model of the Martian atmosphere - Part 1: a diagnostic analysis

    NASA Astrophysics Data System (ADS)

    Whitehouse, S. G.; Lewis, S. R.; Moroz, I. M.; Read, P. L.

    2005-06-01

    In this paper we derive a reduced-order approximation to the vertical and horizontal structure of a simplified model of the baroclinically unstable Martian atmosphere. The original model uses the full hydrostatic primitive equations on a sphere, but has only highly simplified schemes to represent the detailed physics of the Martian atmosphere, e.g. forcing towards a plausible zonal mean temperature state using Newtonian cooling. Three different norms are used to monitor energy conversion processes in the model and are then compared. When four vertical modes (the barotropic and first three baroclinic modes) are retained in the reduced-order approximation, the correlation norm captures approximately 90% of the variance, while the kinetic energy and total energy norms capture approximately 83% and 78% of the kinetic and total energy respectively. We show that the leading order Proper Orthogonal Decomposition (POD) modes represent the dominant travelling waves in the baroclinically-unstable, winter hemisphere. In part 2 of our study we will develop a hierarchy of truncated POD-Galerkin expansions of the model equations using up to four vertical modes.

  4. Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms.

    PubMed

    Kerley, Conor P; Elnazir, Basil; Faul, John; Cormican, Liam

    2015-06-01

    Vitamin D deficiency (VDD) is highly prevalent worldwide. The classical role for vitamin D is to regulate calcium absorption form the gastrointestinal tract and influence bone health. Recently vitamin D receptors and vitamin D metabolic enzymes have been discovered in numerous sites systemically supporting diverse extra-skeletal roles of vitamin D, for example in asthmatic disease. Further, VDD and asthma share several common risk factors including high latitude, winter season, industrialization, poor diet, obesity, and dark skin pigmentation. Vitamin D has been demonstrated to possess potent immunomodulatory effects, including effects on T cells and B cells as well as increasing production of antimicrobial peptides (e.g. cathelicidin). This immunomodulation may lead to asthma specific clinical benefits in terms of decreased bacterial/viral infections, altered airway smooth muscle-remodeling and -function as well as modulation of response to standard anti-asthma therapy (e.g. glucocorticoids and immunotherapy). Thus, vitamin D and its deficiency have a number of biological effects that are potentially important in altering the course of disease pathogenesis and severity in asthma. The purpose of this first of a two-part review is to review potential mechanisms whereby altering vitamin D status may influence asthmatic disease. PMID:25732539

  5. 12 CFR Appendix A to Part 1024 - Instructions for Completing HUD-1 and HUD-1A Settlement Statements; Sample HUD-1 and HUD-1A...

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... statement, required under section 4 of RESPA and 12 CFR part 1024 (Regulation X) of the Bureau of Consumer.... Refer to the definitions section of the regulations (12 CFR 1024.2) for specific definitions of many of... user. For other loans covered by 12 CFR part 1024 (Regulation X) which finance construction of a...

  6. 12 CFR Appendix A to Part 1024 - Instructions for Completing HUD-1 and HUD-1a Settlement Statements; Sample HUD-1 and HUD-1a...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... statement, required under section 4 of RESPA and 12 CFR part 1024 (Regulation X) of the Bureau of Consumer.... Refer to the definitions section of the regulations (12 CFR 1024.2) for specific definitions of many of... user. For other loans covered by 12 CFR part 1024 (Regulation X) which finance construction of a...

  7. 12 CFR Appendix A to Part 1024 - Instructions for Completing HUD-1 and HUD-1a Settlement Statements; Sample HUD-1 and HUD-1a...

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... statement, required under section 4 of RESPA and 12 CFR part 1024 (Regulation X) of the Bureau of Consumer.... Refer to the definitions section of the regulations (12 CFR 1024.2) for specific definitions of many of... user. For other loans covered by 12 CFR part 1024 (Regulation X) which finance construction of a...

  8. 24 CFR Appendix A to Part 3500 - Instructions for Completing HUD-1 and HUD-1a Settlement Statements; Sample HUD-1 and HUD-1a...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... instructions for completing the HUD-1 settlement statement, required under section 4 of RESPA and 24 CFR part... (24 CFR 3500.2) for specific definitions of many of the terms that are used in these instructions... is converted to a loan to finance purchase by the first user. For other loans covered by 24 CFR...

  9. 24 CFR Appendix A to Part 3500 - Instructions for Completing HUD-1 and HUD-1a Settlement Statements; Sample HUD-1 and HUD-1a...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... instructions for completing the HUD-1 settlement statement, required under section 4 of RESPA and 24 CFR part... (24 CFR 3500.2) for specific definitions of many of the terms that are used in these instructions... is converted to a loan to finance purchase by the first user. For other loans covered by 24 CFR...

  10. 24 CFR Appendix A to Part 3500 - Instructions for Completing HUD-1 and HUD-1a Settlement Statements; Sample HUD-1 and HUD-1a...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... instructions for completing the HUD-1 settlement statement, required under section 4 of RESPA and 24 CFR part... (24 CFR 3500.2) for specific definitions of many of the terms that are used in these instructions... is converted to a loan to finance purchase by the first user. For other loans covered by 24 CFR...

  11. 50 CFR Table 1a to Part 660... - 2009, Specifications of ABCs, OYs, and HGs, by Management Area (weights in metric tons)

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., by Management Area (weights in metric tons) 1a Table 1a to Part 660, Subpart C Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF..., Subpart C—2009, Specifications of ABCs, OYs, and HGs, by Management Area (weights in metric tons)...

  12. 50 CFR Table 1a to Part 660... - 2009, Specifications of ABCs, OYs, and HGs, by Management Area (weights in metric tons)

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., by Management Area (weights in metric tons) 1a Table 1a to Part 660, Subpart G Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF..., Subpart G—2009, Specifications of ABCs, OYs, and HGs, by Management Area (weights in metric tons) Link...

  13. 50 CFR Table 1a to Part 660... - 2013, Specifications of OFL, ABC, ACL, ACT and Fishery Harvest guidelines (weights in metric tons)

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 13 2014-10-01 2014-10-01 false 2013, Specifications of OFL, ABC, ACL, ACT and Fishery Harvest guidelines (weights in metric tons) 1a Table 1a to Part 660, Subpart C Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC...

  14. 50 CFR Table 1a to Part 660... - 2013, Specifications of OFL, ABC, ACL, ACT and Fishery Harvest guidelines (weights in metric tons)

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 13 2013-10-01 2013-10-01 false 2013, Specifications of OFL, ABC, ACL, ACT and Fishery Harvest guidelines (weights in metric tons) 1a Table 1a to Part 660, Subpart C Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE (CONTINUED) FISHERIES...

  15. Elongation Factor 1A-1 Is a Mediator of Hepatocyte Lipotoxicity Partly through Its Canonical Function in Protein Synthesis

    PubMed Central

    Stoianov, Alexandra M.; Robson, Debra L.; Hetherington, Alexandra M.; Sawyez, Cynthia G.; Borradaile, Nica M.

    2015-01-01

    Elongation factor 1A-1 (eEF1A-1) has non-canonical functions in regulation of the actin cytoskeleton and apoptosis. It was previously identified through a promoter-trap screen as a mediator of fatty acid-induced cell death (lipotoxicity), and was found to participate in this process downstream of ER stress. Since ER stress is implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), we investigated the mechanism of action of eEF1A-1 in hepatocyte lipotoxicity. HepG2 cells were exposed to excess fatty acids, followed by assessments of ER stress, subcellular localization of eEF1A-1, and cell death. A specific inhibitor of eEF1A-1 elongation activity, didemnin B, was used to determine whether its function in protein synthesis is involved in lipotoxicity. Within 6 h, eEF1A-1 protein was modestly induced by high palmitate, and partially re-localized from its predominant location at the ER to polymerized actin at the cell periphery. This early induction and subcellular redistribution of eEF1A-1 coincided with the onset of ER stress, and was later followed by cell death. Didemnin B did not prevent the initiation of ER stress by high palmitate, as indicated by eIF2α phosphorylation. However, consistent with sustained inhibition of eEF1A-1-dependent elongation activity, didemnin B prevented the recovery of protein synthesis and increase in GRP78 protein that are normally associated with later phases of the response to ongoing ER stress. This resulted in decreased palmitate-induced cell death. Our data implicate eEF1A-1, and its function in protein synthesis, in hepatocyte lipotoxicity. PMID:26102086

  16. Simulating the Heterogeneity in Braided Channel Belt Deposits: Part 1. A Geometric-Based Methodology and Code

    SciTech Connect

    Ramanathan, Ramya; Guin, Arijit; Ritzi, Robert W.; Dominic, David F.; Freedman, Vicky L.; Scheibe, Timothy D.; Lunt, Ian A.

    2010-04-29

    A geometric-based simulation methodology was developed and incorporated into a computer code to model the hierarchical stratal architecture, and the corresponding spatial distribution of permeability, in braided channel belt deposits. The code creates digital models of these deposits as a three-dimensional cubic lattice, which can be used directly in numerical aquifer or reservoir models for fluid flow. The digital models have stratal units defined from the km scale to the cm scale. These synthetic deposits are intended to be used as high-resolution base cases in various areas of computational research on multiscale flow and transport processes, including the testing of upscaling theories. The input parameters are primarily univariate statistics. These include the mean and variance for characteristic lengths of sedimentary unit types at each hierarchical level, and the mean and variance of log-permeability for unit types defined at only the lowest level (smallest scale) of the hierarchy. The code has been written for both serial and parallel execution. The methodology is described in Part 1 of this series. In Part 2, models generated by the code are presented and evaluated.

  17. Improved blade profile loss and deviation angle models for advanced transonic compressor bladings. Part 1: A model for subsonic flow

    SciTech Connect

    Koenig, W.M.; Hennecke, D.K.; Fottner, L.

    1996-01-01

    New blading concepts as used in modern transonic axial-flow compressors require improved loss and deviation angle correlations. The new model presented in this paper incorporates several elements and treats blade-row flows having subsonic and supersonic inlet conditions separately. In the first part of this paper two proved and well-established profile loss correlations for subsonic flows are extended to quasi-two-dimensional conditions and to custom-tailored blade designs. Instead of a deviation angle correlation, a simple method based on singularities is utilized. The comparison between the new model and a recently published model demonstrates the improved accuracy in prediction of cascade performance achieved by the new model.

  18. Parental experiences of providing skin-to-skin care to their newborn infant—Part 1: A qualitative systematic review

    PubMed Central

    Anderzén-Carlsson, Agneta; Lamy, Zeni Carvalho; Eriksson, Mats

    2014-01-01

    Aim To describe parental experiences of providing skin-to-skin care (SSC) to their newborn infants. Background SSC care for newborn infants has been reported to have positive physiological and psychological benefits to the infants and their parents. No systematic review regarding parental experiences has been identified. Design In this first part of a meta-study, the findings of a systematic literature review on parental experience of SSC care are presented. Data sources Four databases were searched, without year or language limitations, up until December 2013. Manual searches were performed in reference lists and in a bibliography of the topic. Review methods After a quality-appraisal process, data from the original articles were extracted and analysed using qualitative content analysis. Results The systematic and manual searches led to the inclusion of 29 original qualitative papers from nine countries, reporting experiences from 401 mothers and 94 fathers. Two themes that characterized the provision of SSC emerged: a restoring experience and an energy-draining experience. Conclusion This review has added scientific and systematic knowledge about parental experiences of providing SSC. Further research about fathers’ experiences is recommended. PMID:25319746

  19. The representation of solar cycle signals in stratospheric ozone - Part 1: A comparison of recently updated satellite observations

    NASA Astrophysics Data System (ADS)

    Maycock, Amanda C.; Matthes, Katja; Tegtmeier, Susann; Thiéblemont, Rémi; Hood, Lon

    2016-08-01

    Changes in incoming solar ultraviolet radiation over the 11-year solar cycle affect stratospheric ozone abundances. It is important to quantify the magnitude, structure, and seasonality of the associated solar-ozone response (SOR) to understand the impact of the 11-year solar cycle on climate. Part 1 of this two-part study uses multiple linear regression analysis to extract the SOR in a number of recently updated satellite ozone datasets covering different periods within the epoch 1970 to 2013. The annual mean SOR in the updated version 7.0 (v7.0) Stratospheric Aerosol and Gas Experiment (SAGE) II number density dataset (1984-2004) is very consistent with that found in the previous v6.2. In contrast, we find a substantial decrease in the magnitude of the SOR in the tropical upper stratosphere in the SAGE II v7.0 mixing ratio dataset (˜ 1 %) compared to the v6.2 (˜ 4 %). This difference is shown to be largely attributable to the change in the independent stratospheric temperature dataset used to convert SAGE II ozone number densities to mixing ratios. Since these temperature records contain substantial uncertainties, we suggest that datasets based on SAGE II number densities are currently most reliable for evaluating the SOR. We further analyse three extended ozone datasets that combine SAGE II v7.0 number densities with more recent GOMOS (Global Ozone Monitoring by Occultation of Stars) or OSIRIS (Optical Spectrograph and Infrared Imager System) measurements. The extended SAGE-OSIRIS dataset (1984-2013) shows a smaller and less statistically significant SOR across much of the tropical upper stratosphere compared to the SAGE II data alone. In contrast, the two SAGE-GOMOS datasets (1984-2011) show SORs that are in closer agreement with the original SAGE II data and therefore appear to provide a more reliable estimate of the SOR. We also analyse the SOR in the recent Solar Backscatter Ultraviolet Instrument (SBUV) Merged Ozone Dataset (SBUVMOD) version 8.6 (VN8

  20. Part 1. A time-series study of ambient air pollution and daily mortality in Shanghai, China.

    PubMed

    Kan, Haidong; Chen, Bingheng; Zhao, Naiqing; London, Stephanie J; Song, Guixiang; Chen, Guohai; Zhang, Yunhui; Jiang, Lili

    2010-11-01

    Although the relation between outdoor air pollution and daily mortality has been examined in several Chinese cities, there are still a number of key scientific issues to be addressed concerning the health effects of air pollution in China. Given the changes over the past decade in concentrations and sources of air pollution (e.g., the change from one predominant source [coal combustion], which was typical of the twentieth century, to a mix of sources [coal combustion and motor-vehicle emissions]) and transition in China, it is worthwhile to investigate the acute effects of outdoor air pollution on mortality outcomes in the country. We conducted a time-series study to investigate the relation between outdoor air pollution and daily mortality in Shanghai using four years of daily data (2001-2004). This study is a part of the Public Health and Air Pollution in Asia (PAPA) program supported by the Health Effects Institute (HEI). We collected data on daily mortality, air pollution, and weather from the Shanghai Municipal Center of Disease Control and Prevention (SMCDCP), Shanghai Environmental Monitoring Center, and Shanghai Meteorologic Bureau. An independent auditing team assigned by HEI validated all the data. Our statistical analysis followed the Common Protocol of the PAPA program (found at the end of this volume). Briefly, a natural-spline model was used to analyze the mortality, air pollution, and covariate data. We first constructed the basic models for various mortality outcomes excluding variables for air pollution, and used the partial autocorrelation function of the residuals to guide the selection of degrees of freedom for time trend and lag days for the autoregression terms. Thereafter, we introduced the pollutant variables and analyzed their effects on mortality outcomes, including both mortality due to all natural (nonaccidental) causes and cause-specific mortality. We fitted single- and multipollutant models to assess the stability of the effects of the

  1. Calidad de Imagen del Telescopio UNAM212

    NASA Astrophysics Data System (ADS)

    Cobos, F. J.; Teiada de Vargas, C.

    1987-05-01

    El telescopio UNAM2l2, del Observatorio Astronómico Nacional, situado en la Sierra de San Pedro Mártir (Baja California, México), cumplira en un futuro muy cercano siete años de uso para fines de investigación astronómica. Aunque en este tiempo no se ha efectuado un estudio sistemático acerca de su comportamiento óptico y de los factores que influyen en la calidad de las imágenes, se han realizado pruebas diversas, estudios parciales y reuniones especificas, cuyos resultados no siempre se han difundido ampliamente y generalmente no se han presentado por escrito. Es por ello que hemos creido necesario intentar una recopilación de la información existente para poder con ella establecer un diagnóstjco que, aunque no sea definitivo, sirva de base para futuros trabajos tendientes a optimizar el comportamiento óptico del telescopio. Es evidente que un buen número de las conclusiones que se presentan son resultado del trabajo de muchas personas ó de esfuerzos colectivos. Asimismo, hemos tratado de localizar información bibliográfica que pueda ser de utilidad. Nuestro objetivo primordial ha consistido en centrarnos en la óptica del telescopio y su calidad, pero también se han considerado otros aspectos que puedan afectar las imágenes obtenidas tales como: celda del primario, `seeing' local y externo, flexiones posibles en la estructura mecánica del telescopio, etc.

  2. 47 CFR Appendix A to Part 1 - A Plan of Cooperative Procedure in Matters and Cases Under the Provisions of Section 410 of the...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false A Plan of Cooperative Procedure in Matters and Cases Under the Provisions of Section 410 of the Communications Act of 1934 A Appendix A to Part 1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Pt. 1, App. A Appendix A to Part 1—A Plan of Cooperative...

  3. 47 CFR Appendix A to Part 1 - A Plan of Cooperative Procedure in Matters and Cases Under the Provisions of Section 410 of the...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false A Plan of Cooperative Procedure in Matters and Cases Under the Provisions of Section 410 of the Communications Act of 1934 A Appendix A to Part 1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Pt. 1, App. A Appendix A to Part 1—A Plan of Cooperative...

  4. 47 CFR Appendix A to Part 1 - A Plan of Cooperative Procedure in Matters and Cases Under the Provisions of Section 410 of the...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false A Plan of Cooperative Procedure in Matters and Cases Under the Provisions of Section 410 of the Communications Act of 1934 A Appendix A to Part 1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Pt. 1, App. A Appendix A to Part 1—A Plan of Cooperative...

  5. Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: non-symmetric inhibitors with potent activity against genotype 1a and 1b.

    PubMed

    Giroux, Simon; Bilimoria, Darius; Cadilhac, Caroline; Cottrell, Kevin M; Denis, Francois; Dietrich, Evelyne; Ewing, Nigel; Henderson, James A; L'Heureux, Lucille; Mani, Nagraj; Morris, Mark; Nicolas, Olivier; Reddy, T Jagadeeswar; Selliah, Subajini; Shawgo, Rebecca S; Xu, Jinwang; Chauret, Nathalie; Berlioz-Seux, Francoise; Chan, Laval C; Das, Sanjoy K; Grillot, Anne-Laure; Bennani, Youssef L; Maxwell, John P

    2015-02-15

    The discovery of non-symmetric thienoimidazole-containing HCV NS5A inhibitors is described. The inhibitors herein reported display high potencies against both genotype 1a and 1b. In this follow-up manuscript, we discuss the importance of the linker aromaticity to achieve high potency, particularly against genotype 1a. PMID:25597006

  6. Aeroservoelastic Testing of Free Flying Wind Tunnel Models Part 1: A Sidewall Supported Semispan Model Tested for Gust Load Alleviation and Flutter Suppression

    NASA Technical Reports Server (NTRS)

    Scott, Robert C.; Vetter, Travis K.; Penning, Kevin B.; Coulson, David A.; Heeg, Jennifer.

    2013-01-01

    of a two part document. Part 2 is titled: "Aeroservoelastic Testing of Free Flying Wind Tunnel Models, Part 2: A Centerline Supported Fullspan Model Tested for Gust Load Alleviation." A team comprised of the Air Force Research Laboratory (AFRL), Northrop Grumman, Lockheed Martin, and the NASA Langley Research Center conducted three aeroservoelastic wind tunnel tests in the Transonic Dynamics Tunnel to demonstrate active control technologies relevant to large, flexible vehicles. In the first of these three tests, a semispan, aeroelastically scaled, wind tunnel model of a flying wing SensorCraft vehicle was mounted to a force balance to demonstrate gust load alleviation. In the second and third tests, the same wing was mated to a new, multi-degree of freedom, sidewall mount. This mount allowed the half-span model to translate vertically and pitch at the wing root, allowing better simulation of the full span vehicle's rigid body modes. Gust load alleviation (GLA) and Body freedom flutter (BFF) suppression were successfully demonstrated. The rigid body degrees-of-freedom required that the model be flown in the wind tunnel using an active control system. This risky mode of testing necessitated that a model arrestment system be integrated into the new mount. The safe and successful completion of these free flying tests required the development and integration of custom hardware and software. This paper describes the many systems, software, and procedures that were developed as part of this effort.

  7. 33 CFR 137.70 - Specialized knowledge or experience on the part of persons specified in § 137.1(a).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Specialized knowledge or... INNOCENT LAND-OWNER DEFENSE Standards and Practices § 137.70 Specialized knowledge or experience on the... located, persons specified in § 137.1(a) must take into account their own specialized knowledge of...

  8. Semipermeable membrane devices link site-specific contaminants to effects: Part 1 - Induction of CYP1A in rainbow trout from contaminants in Prince William Sound, Alaska.

    PubMed

    Springman, Kathrine R; Short, Jeffrey W; Lindeberg, Mandy R; Maselko, Jacek M; Khan, Colin; Hodson, Peter V; Rice, Stanley D

    2008-12-01

    Extracts from semi-permeable membrane devices (SPMDs) deployed on beaches in Prince William Sound (PWS), Alaska, were used to evaluate if complex contaminant mixtures from different sources can be distinguished by the resulting cytochrome P450 1A (CYP1A) activity in exposed test animals. Deployment sites included canneries, salmon hatcheries, and beaches where lingering oil remains from discharges during the 1964 earthquake or the 1989 Exxon Valdez oil spill. Other sites were selected at random to evaluate region-wide contaminant inputs or were located in salmon streams to evaluate contaminants carried and released by migrating salmon carcasses following reproduction. Following standard deployments of approximately 28 d, an aliquot of the accumulated contaminants was intraperitoneally injected without cleanup into juvenile rainbow trout (Oncorhynchus mykiss). After 2 d and 7 d, the activity of CYP1A was measured by the ethoxyresorufin-o-deethylase (EROD) assay. Exposure to extracts from the oiled sites and one hatchery site with numerous creosote pilings elicited strong EROD responses, whereas fish exposed to salmon stream extracts elicited weak but significant responses during late summer compared to late spring. Responses from the other sites were not significant, indicating contaminants from these sources are unlikely to cause CYP1A induction in resident biota. Rather than simply assessing extant contaminants, this method evaluates the potency of the different sites for bringing about aryl hydrocarbon receptor responses in resident biota. PMID:18845333

  9. Towards novel 5-HT7versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: design, synthesis, and antidepressant properties. Part II.

    PubMed

    Canale, Vittorio; Kurczab, Rafał; Partyka, Anna; Satała, Grzegorz; Witek, Jagna; Jastrzębska-Więsek, Magdalena; Pawłowski, Maciej; Bojarski, Andrzej J; Wesołowska, Anna; Zajdel, Paweł

    2015-03-01

    A 26-membered library of novel long-chain arylpiperazines, which contained primary and tertiary amides of cyclic amino acids (proline and 1,2,3,4-tetrahydroisoquinoline-3-carboxamide) in the terminal fragment was synthesized and biologically evaluated for binding affinity for 5-HT7 and 5-HT1A receptors. Docking studies confirmed advantages of Tic-amide over Pro-amide fragment for interaction with 5-HT7 receptors. Selected compounds 32 and 28, which behaved as 5-HT7Rs antagonist and 5-HT1A partial agonist, respectively, produced antidepressant-like effects in the forced swim test in mice after acute treatment in doses of 10 mg/kg (32) and 1.25 mg/kg (28). Compound 32 reduced immobility in a manner similar to the selective 5-HT7 antagonist SB-269970. PMID:25555143

  10. High consistency forming process for paper making. Part 1. A research, development, and demonstration program plan for the US Papermaking Industry. Final report

    SciTech Connect

    Not Available

    1980-04-01

    The subject of research, development, and demonstration (RD and D) of energy conserving technologies applicable to papermaking operations downstream of the pulping process is addressed. An RD and D Program Plan is presented based on a survey of leading representatives of the papermaking industry, equipment manufacturers, consulting engineering firms, the American Paper Institute, and the Technical Association of the Pulp and Paper Industry. For perspective, the program plan is presented against the general background of the industry's current issues and concerns. The second part of the paper, Phase I, final report, deals with papermaking test facilities. The case for a centralized test facility is discussed. The results of a survey of existing pilot paper machines are presented. The energy saving potential of high consistency forming is considered and related to existing evidence. Simple theoretical models for the press nip action and the drying process are developed to predict where high consistency forming will reduce energy consumption. A special dynamic former has been designed, fabricated, and commissioned to allow development of a laboratory high consistency headbox. The design and construction of a low speed headbox has been completed and the complete system operated. Special equipment and techniques for the measurement of the water and air permeability of sheet samples have been developed and are described.

  11. Geologic Interpretation of Data Sets Collected by Planetary Analog Geology Traverses and by Standard Geologic Field Mapping. Part 1; A Comparison Study

    NASA Technical Reports Server (NTRS)

    Eppler, Dean B.; Bleacher, Jacob F.; Evans, Cynthia A.; Feng, Wanda; Gruener, John; Hurwitz, Debra M.; Skinner, J. A., Jr.; Whitson, Peggy; Janoiko, Barbara

    2013-01-01

    Geologic maps integrate the distributions, contacts, and compositions of rock and sediment bodies as a means to interpret local to regional formative histories. Applying terrestrial mapping techniques to other planets is challenging because data is collected primarily by orbiting instruments, with infrequent, spatiallylimited in situ human and robotic exploration. Although geologic maps developed using remote data sets and limited "Apollo-style" field access likely contain inaccuracies, the magnitude, type, and occurrence of these are only marginally understood. This project evaluates the interpretative and cartographic accuracy of both field- and remote-based mapping approaches by comparing two 1:24,000 scale geologic maps of the San Francisco Volcanic Field (SFVF), north-central Arizona. The first map is based on traditional field mapping techniques, while the second is based on remote data sets, augmented with limited field observations collected during NASA Desert Research & Technology Studies (RATS) 2010 exercises. The RATS mission used Apollo-style methods not only for pre-mission traverse planning but also to conduct geologic sampling as part of science operation tests. Cross-comparison demonstrates that the Apollo-style map identifies many of the same rock units and determines a similar broad history as the field-based map. However, field mapping techniques allow markedly improved discrimination of map units, particularly unconsolidated surficial deposits, and recognize a more complex eruptive history than was possible using Apollo-style data. Further, the distribution of unconsolidated surface units was more obvious in the remote sensing data to the field team after conducting the fieldwork. The study raises questions about the most effective approach to balancing mission costs with the rate of knowledge capture, suggesting that there is an inflection point in the "knowledge capture curve" beyond which additional resource investment yields progressively

  12. Assessing Subaqueous Mudflow Hazard on the Mississippi River Delta Front, Part 1: A Historical Perspective on Mississippi River Delta Front Sedimentation

    NASA Astrophysics Data System (ADS)

    Maloney, J. M.; Bentley, S. J.; Obelcz, J.; Xu, K.; Miner, M. D.; Georgiou, I. Y.; Hanegan, K.; Keller, G.

    2014-12-01

    potential mudflow hazards associated with new MRDF sedimentation rates and patterns (See Part 2, Obelcz et al.).

  13. Reconstruction of geomagnetic activity and near-Earth interplanetary conditions over the past 167 yr - Part 1: A new geomagnetic data composite

    NASA Astrophysics Data System (ADS)

    Lockwood, M.; Barnard, L.; Nevanlinna, H.; Owens, M. J.; Harrison, R. G.; Rouillard, A. P.; Davis, C. J.

    2013-11-01

    We present a new composite of geomagnetic activity which is designed to be as homogeneous in its construction as possible. This is done by only combining data that, by virtue of the locations of the source observatories used, have similar responses to solar wind and IMF (interplanetary magnetic field) variations. This will enable us (in Part 2, Lockwood et al., 2013a) to use the new index to reconstruct the interplanetary magnetic field, B, back to 1846 with a full analysis of errors. Allowance is made for the effects of secular change in the geomagnetic field. The composite uses interdiurnal variation data from Helsinki for 1845-1890 (inclusive) and 1893-1896 and from Eskdalemuir from 1911 to the present. The gaps are filled using data from the Potsdam (1891-1892 and 1897-1907) and the nearby Seddin observatories (1908-1910) and intercalibration achieved using the Potsdam-Seddin sequence. The new index is termed IDV(1d) because it employs many of the principles of the IDV index derived by Svalgaard and Cliver (2010), inspired by the u index of Bartels (1932); however, we revert to using one-day (1d) means, as employed by Bartels, because the use of near-midnight values in IDV introduces contamination by the substorm current wedge auroral electrojet, giving noise and a dependence on solar wind speed that varies with latitude. The composite is compared with independent, early data from European-sector stations, Greenwich, St Petersburg, Parc St Maur, and Ekaterinburg, as well as the composite u index, compiled from 2-6 stations by Bartels, and the IDV index of Svalgaard and Cliver. Agreement is found to be extremely good in all cases, except two. Firstly, the Greenwich data are shown to have gradually degraded in quality until new instrumentation was installed in 1915. Secondly, we infer that the Bartels u index is increasingly unreliable before about 1886 and overestimates the solar cycle amplitude between 1872 and 1883 and this is amplified in the proxy data used

  14. Incrementando la calidad de los espectros echelle

    NASA Astrophysics Data System (ADS)

    Pintado, O. I.; Adelman, S. J.

    For more than 10 years we have obtained spectra with the REOSC and EBASIM spectrograph at CASLEO. Usually we use IRAF to extract the spectra. Then we normalized the 1-d spectra and measured the lines with REDUCE. In this paper we compare the results obtained using each program in different parts of the spectrum measurements process. Wih EBASIM, or 4th magnitude stars and 120 minute exposures we obtain signal-to-noise ratios near 500 in the center of the orders

  15. Equal Educational Opportunity: Hearings Before the Select Committee on Equal Educational Opportunity of the United States Senate, Ninety-First Congress, Second Session on Equal Educational Opportunity. Parts 1A, 1B, 2, 3A, 3B, 3C, and 3D.

    ERIC Educational Resources Information Center

    Congress of the U.S., Washington, DC. Senate Select Committee on Equal Educational Opportunity.

    These hearings before the Senate Select Committee on Equal Educational Opportunity are organized in three parts, the contents of which are as follows: Part 1A and Part 2 comprise the "Introduction," with opening statements by a number of Senators, followed by the presentations of other witnesses. The focus of these two parts is on such topics as…

  16. Synthesis and structure-activity relationships of a new model of arylpiperazines. Part 7: Study of the influence of lipophilic factors at the terminal amide fragment on 5-HT(1A) affinity/selectivity.

    PubMed

    López-Rodríguez, María L; Ayala, David; Viso, Alma; Benhamú, Bellinda; de La Pradilla, Roberto Fernández; Zarza, Fernando; Ramos, José A

    2004-03-15

    The influence of lipophilic factors at the amide fragment of a new series of (+/-)-7a-alkyl-2-[4-(4-arylpiperazin-1-yl)butyl]-1,3-dioxoperhydropyrrolo[1,2-c]imidazoles 2 and of (+/-)-7a-alkyl-2-[(4-arylpiperazin-1-yl)methyl]-1,3-dioxoperhydropyrrolo[1,2-c]imidazoles 3 has been studied. Variations of logP have been carried out by introducing different hydrocarbonated substituents (R(1)) at the position 7a of the bicyclohydantoin, namely the non-pharmacophoric part. All the new compounds exhibit high potency for the 5-HT(1A) receptor; however, affinities for the alpha(1) receptor are high for compounds 2a-l while compounds 3a-f are selective over this adrenergic receptor. On the other hand, differences in logP do not notably affect the K(i) values for the above receptors. PMID:15018929

  17. Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)

    USGS Publications Warehouse

    Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; Rivera, M.C., (translator); Munoz, A.

    1998-01-01

    La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

  18. Longitudinal changes in adipose tissue of dairy cows from late pregnancy to lactation. Part 2: The SIRT-PPARGC1A axis and its relationship with the adiponectin system.

    PubMed

    Weber, M; Locher, L; Huber, K; Rehage, J; Tienken, R; Meyer, U; Dänicke, S; Webb, L; Sauerwein, H; Mielenz, M

    2016-02-01

    The transition period in dairy cows is characterized by major changes in glucose and adipose tissue metabolism. The Sirtuin-1 (SIRT1) PPARγ co-activator 1α (PPARGC1A) axis might be related to the adiponectin (ADIPOQ) system to orchestrate the regulation of these processes. We aimed to assess the mRNA abundance of the aforementioned components in one visceral and one subcutaneous fat depot, together with the ADIPOQ concentrations in serum of dairy cows from late gestation to early lactation. In addition, the effect of 2 diets differing in energy density was tested. Twenty pluriparous German Holstein cows were all kept on the same silage-based diet until d 42 antepartum. From then on until d 1 antepartum, 10 animals each were assigned to either high-concentrate (60:40 concentrate:roughage) or low-concentrate (30:70) diets. Both groups were further subdivided into a control and a niacin group, the latter receiving 24 g/d nicotinic acid from d -42 until d 24. From d 1 postpartum (p.p.) to d 24 p.p., the concentrate portion was increased from 30 to 50% for all cows. Biopsies of subcutaneous (SCAT) and retroperitoneal adipose tissue (RPAT) were taken at d -42, 1, 21, and 100 relative to parturition. Blood samples were drawn along with the biopsies as well as on d -21, -14, -7, -3, 1, 3, 7, 14, 21, 28, 35, 42, 63, 82, and 100 relative to calving. Quantification of target mRNA was done using quantitative PCR and serum ADIPOQ concentration was measured via ELISA. The feeding regimen did not affect the variables examined. Serum ADIPOQ concentrations decreased toward parturition, returned to precalving levels within 1 wk after parturition, and remained on a constant level until the end of the experiment. The mRNA abundance of SIRT1, PPARGC1A, NAMPT, and the ADIPOQ receptors 1 (ADIPOR1) and 2 (ADIPOR2) changed in SCAT and RPAT during the considered time period. Comparing SCAT and RPAT, the mRNA of SIRT1, ADIPOR1, and ADIPOR2 were more abundant in RPAT, whereas PPARGC1A and

  19. Spacer conformation in biologically active molecules. Part 2. Structure and conformation of 4-[2-(diphenylmethylamino)ethyl]-1-(2-methoxyphenyl) piperazine and its diphenylmethoxy analog—potential 5-HT 1A receptor ligands

    NASA Astrophysics Data System (ADS)

    Karolak-Wojciechowska, J.; Fruziński, A.; Czylkowski, R.; Paluchowska, M. H.; Mokrosz, M. J.

    2003-09-01

    As a part of studies on biologically active molecule structures with aliphatic linking chain, the structures of 4-[2-diphenylmethylamino)ethyl]-1-(2-methoxyphenyl)piperazine dihydrochloride ( 1) and 4-[2-diphenylmethoxy)ethyl]-1-(2-methoxyphenyl)piperazine fumarate ( 2) have been reported. In both compounds, four atomic non-all-carbons linking chains (N)C-C-X-C are present. The conformation of that linking spacer depends on the nature of the X-atom. The preferred conformation for chain with XNH has been found to be fully extended while for that with XO—the bend one. It was confirmed by conformational calculations (strain energy distribution and random search) and crystallographic data, including statistics from CCDC.

  20. Amylase α-1A (AMY1A)

    PubMed Central

    Jain, Sarika; Roy, Somak; Amin, Milon; Acquafondata, Marie; Yin, Ming; LaFramboise, William; Bastacky, Sheldon; Pantanowitz, Liron; Dhir, Rajiv; Parwani, Anil

    2014-01-01

    Chromophobe renal cell carcinoma (ChRCC) and oncocytoma present with a perplexing overlap of morphologic and immunohistochemical features. ChRCC have deletions in the 1p21.1 region including the amylase α-1A gene (AMY1A). No such deletions are found in oncocytoma. Instead, oncocytomas shared other deletions on chromosome 1: 1p31.3, 1q25.2, and 1q44. We performed AMY1A immunostaining on 75 oncocytomas (57 tissue microarray [TMA] cores, 18 whole slides) and 54 ChRCCs (20 TMA cores, 34 whole slides). Staining was assessed using the H-score method. The intensity was graded as follows: no staining=0, weak=1, moderate=2, and strong=3. The AMY1A immunostain preferentially stained the distal tubules and collecting ducts of normal kidney. All oncocytomas (100%) expressed AMY1A with an H-score that varied from 100 to 300 (mean 205). Mild to moderate heterogeneity in staining intensity was noted within a given oncocytoma. For oncocytomas, 87% (65/75) cases had H-scores of at least 120 with a mean score of 221. Notably, the 13% (10/75) of oncocytoma cases that had an H-score of 100 were derived from the TMA. A total of 87% (47/54) of the ChRCC cases were negative for the AMY1A immunostain. Of the ChRCC cases, 4% (2/54) showed very weak cytoplasmic staining (H-score of 70 each), which was less than the lowest H-score of oncocytoma cases. All 5 cases of ChRCC, which showed an H-score of 100 or more, were referred to as eosinophilic variants of ChRCC. Three of these 5 cases showed a very nondescript, diffuse staining of the cytoplasm. Two of these 5 cases showed an H-score of 130. We think that as the staining pattern of these 2 cases is similar to that of oncocytoma, they should be put in a category of renal oncocytic neoplasms favoring oncocytoma. This result shows that AMY1A staining could be very helpful in further classifying even a subset of the eosinophilic variants of ChRCC. The difference between ChRCC and oncocytoma was statistically significant (χ2 test, P<0

  1. Apollo Mission Techniques Lunar Orbit Activities - Part 1a

    NASA Technical Reports Server (NTRS)

    Interbartolo, Michael A.

    2009-01-01

    This slide presentation reviews the planned sequence of events and the rationale for all lunar missions, and the flight experiences and lessons learned for the lunar orbit activities from a trajectory perspective. Shown are trajectories which include the moon's position at the various stages in the complete trip from launch, to the return and reentry. Included in the presentation are objectives and the sequence of events,for the Apollo 8, and Apollo 10. This is followed by a discussion of Apollo 11, including: the primary mission objective, the sequence of events, and the flight experience. The next mission discussed was Apollo 12. It reviews the objectives, the ground tracking, procedure changes, and the sequence of events. The aborted Apollo 13 mission is reviewed, including the objectives, and the sequence of events. Brief summaries of the flight experiences for Apollo 14-16 are reviewed. The flight sequence of events of Apollo 17 are discussed. In summary each mission consistently performing precision landings required that Apollo lunar orbit activities devote considerable attention to: (1) Improving fidelity of lunar gravity models, (2) Maximizing availability of ground tracking, (3) Minimizing perturbations on the trajectory, (4) Maximizing LM propellant reserves for hover time. Also the use of radial separation maneuvers (1) allows passive re-rendezvous after each rev, but ... (2) sensitive to small dispersions in initial sep direction

  2. Clinical imaging guidelines part 1: a proposal for uniform methodology.

    PubMed

    Remedios, Denis; Brink, James; Holmberg, Ola; Kawooya, Michael; Mendelson, Richard; Naidoo, Anusha; Reed, Martin; Bettmann, Michael

    2015-01-01

    Inappropriate imaging can lead to unnecessary medical radiologic exposures and cost and may not answer the clinical question. Imaging referral guidelines inform the justification of radiologic procedures and facilitate the choice of the best test first, but their acceptance by referrers, use, and value may be limited by shortcomings in the methodology of development. Focusing on common, essential elements of methodology will help guideline developers. In 2012 and 2013, the International Atomic Energy Agency hosted Technical Meetings on Radiation Protection of Patients Through the Development of Appropriateness Criteria in Diagnostic Imaging. Participants identified and agreed on issues concerning development of imaging referral guidelines. Items based on the Appraisal of Guidelines for Research and Evaluation II instrument were amended with additional items including development and consensus group composition. Consensus was sought on 28 items, 18 of which were agreed should be uniform, and 10 should allow for regional differences. Further work is required to encourage, provide, and identify higher quality evidence and to agree on a grading system for recommendations. Many key areas are common to guideline developers globally, opening the way for international collaboration to help demystify, simplify, and justify. PMID:25441484

  3. The bioavailability of Tamoplex (tamoxifen). Part 1. A pilot study.

    PubMed

    McVie, J G; Simonetti, G P; Stevenson, D; Briggs, R J; Guelen, P J; de Vos, D

    1986-08-01

    Tamoxifen and N-desmethyltamoxifen plasma concentrations were found to be similar after a first single dose and during two months therapy with Tamoplex or Nolvadex in groups of 6 and 8 patients, respectively. Single dose absorption results in 10 healthy male volunteers demonstrated bioequivalence of Tamoplex and Nolvadex 10 mg tablets. A large interindividual variation in tamoxifen absorption data was observed, probably related to the dominating metabolic clearance of tamoxifen. PMID:3747644

  4. MIL1A

    Atmospheric Science Data Center

    2014-09-03

    ... MISR Level 1A camera charge-coupled device (CCD) Science Data: Reformatted Annotated Level 1A product of the CCD science data. ... :  Data Product Specification Versioning History:  Ellipsoid, Terrain, Browse, CCD, Radiance SCAR-B ...

  5. Parts Specialist.

    ERIC Educational Resources Information Center

    Fuqua, Lou; Fuqua, Debbie

    Designed to address the skills that an auto parts specialist must master in order to be effective in the market place, this manual consists of 13 units of instruction. Covered in the units are orientation; human relations; communications; safety; parts and systems identification; stocking, shipping, and receiving; inventory control; cataloging and…

  6. U1A Complex

    SciTech Connect

    2014-10-28

    Some of the most sophisticated experiments in the stockpile stewardship program are conducted in an environmentally safe manner, nearly 1000 feet below the ground at the site. The U1a complex a sprawling underground laboratory and tunnel complex is home to a number of unique capabilities.

  7. U1A Complex

    ScienceCinema

    None

    2015-01-09

    Some of the most sophisticated experiments in the stockpile stewardship program are conducted in an environmentally safe manner, nearly 1000 feet below the ground at the site. The U1a complex a sprawling underground laboratory and tunnel complex is home to a number of unique capabilities.

  8. Motorcycle Parts

    NASA Technical Reports Server (NTRS)

    1993-01-01

    An article in NASA Tech Briefs describing a vacuum bagging process for forming composite parts helped a small Oklahoma Company to improve its manufacturing process. President of Performance Extremes, Larry Ortega, and his partners make motorcycle parts from carbon/epoxy to reduce weight. Using vacuum bags, parts have a better surface and fewer voids inside. When heat used in the vacuum bag process caused deformation upon cooling, a solution found in another tech brief solved the problem. A metal plate inside the vacuum bag made for more even heat transfer. A third article described a simple procedure for repairing loose connector pins, which the company has also utilized.

  9. Phosphodiesterase 1A Modulates Cystogenesis in Zebrafish

    PubMed Central

    Ward, Christopher J.; Leightner, Amanda C.; Smith, Jordan L.; Agarwal, Reema; Harris, Peter C.; Torres, Vicente E.

    2014-01-01

    Substantial evidence indicates the importance of elevated cAMP in polycystic kidney disease (PKD). Accumulation of cAMP in cystic tissues may be, in part, caused by enhanced adenylyl cyclase activity, but inhibition of cAMP degradation by phosphodiesterases (PDE) likely has an important role, because cAMP is inactivated much faster than it is synthesized. PDE1 is the only PDE family activated by Ca2+, which is reduced in PKD cells. To assess the contribution of the PDE1A subfamily to renal cyst formation, we examined the expression and function of PDE1A in zebrafish. We identified two splice isoforms with alternative starts corresponding to human PDE1A1 and PDE1A4. Expression of the two isoforms varied in embryos and adult tissues, and both isoforms hydrolyzed cAMP with Ca2+/calmodulin dependence. Depletion of PDE1A in zebrafish embryos using splice- and translation-blocking morpholinos (MOs) caused pronephric cysts, hydrocephalus, and body curvature. Human PDE1A RNA and the PKA inhibitors, H89 and Rp-cAMPS, partially rescued phenotypes of pde1a morphants. Additionally, MO depletion of PDE1A aggravated phenotypes in pkd2 morphants, causing more severe body curvature, and human PDE1A RNA partially rescued pkd2 morphant phenotypes, pronephric cysts, hydrocephalus, and body curvature. Together, these data indicate the integral role of PDE1A and cAMP signaling in renal development and cystogenesis, imply that PDE1A activity is altered downstream of polycystin-2, and suggest that PDE1A is a viable drug target for PKD. PMID:24700876

  10. Bases para la elaboracion de unidades didacticas de calidad en el area de ciencias (Fisica y Quimica 3 deg ESO)

    NASA Astrophysics Data System (ADS)

    Maccioni, Elena Lucia

    Este Trabajo Fin de Master tiene como objeto, el estudio previo de la educacion de la ciencia en la actualidad y mas destacable, del diseno de las unidades didacticas segun las metodologias mas frecuentes aplicadas por los diferentes sistemas educativos en el area de las Ciencias teniendo en cuenta la importancia y el efecto de la psicologia del alumnado y todo ello como no puede ser de otro modo bajo el corse de la Legislacion aplicable, Estatal, Autonomica y europea. Con estos antecedentes, se extrae cuales son las preguntas que deben contestarse en la elaboracion de una unidad didactica de calidad en el contexto, generacional (edad y sexo), del Proyecto Educativo de Centro, y de la Programacion del Departamento, discutiendo y justificando cada uno de los apartados en que estructuradamente dividiremos dicha Unidad, con un formato manejable, util, y dinamico en el tiempo que sea un verdadero instrumento educativo de aula. Teniendo en cuenta estas premisas, se procede a hacer una recopilacion de una misma unidad didactica publicada por diferentes editoriales, elegidas no al azar, sino en funcion de su penetracion editorial en nuestros centros de ESO, siendo las elegidas (SM y Oxford). Las diferentes unidades seleccionadas son analizadas de forma critica, atendiendo a los criterios generales de calidad bajo parametros cientificos y normativos, concluyendo con la aportacion final que es la redaccion de unas pautas cientifico-pedagogicas, para redactar unidades didacticas de calidad en el area de la Ciencias, en concreto en la Asignatura de Fisica y Quimica de 3º de ESO.

  11. 12 CFR 528.1a - Supplementary guidelines.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REQUIREMENTS § 528.1a Supplementary guidelines. The Office's policy statement found at 12 CFR 528.9 supplements... 24 CFR parts 100 et seq., Federal Reserve Regulation B at 12 CFR part 202, and Federal Reserve Regulation C at 12 CFR part 203....

  12. 12 CFR 528.1a - Supplementary guidelines.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REQUIREMENTS § 528.1a Supplementary guidelines. The Office's policy statement found at 12 CFR 528.9 supplements... 24 CFR parts 100 et seq., Federal Reserve Regulation B at 12 CFR part 202, and Federal Reserve Regulation C at 12 CFR part 203....

  13. 12 CFR 528.1a - Supplementary guidelines.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REQUIREMENTS § 528.1a Supplementary guidelines. The Office's policy statement found at 12 CFR 528.9 supplements... 24 CFR parts 100 et seq., Federal Reserve Regulation B at 12 CFR part 202, and Federal Reserve Regulation C at 12 CFR part 203....

  14. 12 CFR 528.1a - Supplementary guidelines.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REQUIREMENTS § 528.1a Supplementary guidelines. The Office's policy statement found at 12 CFR 528.9 supplements... 24 CFR parts 100 et seq., Federal Reserve Regulation B at 12 CFR part 202, and Federal Reserve Regulation C at 12 CFR part 203....

  15. 12 CFR 528.1a - Supplementary guidelines.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REQUIREMENTS § 528.1a Supplementary guidelines. The Office's policy statement found at 12 CFR 528.9 supplements... 24 CFR parts 100 et seq., Federal Reserve Regulation B at 12 CFR part 202, and Federal Reserve Regulation C at 12 CFR part 203....

  16. MISR Level 1A Products

    Atmospheric Science Data Center

    2013-04-01

    ... MISR Level 1A Products Level 1A Engineering Data File Type 1 and Level 1A Navigation Data Processing ... Product Specification Rev K  (PDF). Transparent software rebuild with Irix 6.5.2 OS. F01_0007 (FM_ENG), ...

  17. Peginterferon Beta-1a Injection

    MedlinePlus

    ... course of disease where symptoms flare up from time to time) of multiple sclerosis (MS, a disease in which ... peginterferon beta-1a injection at around the same time of day each time you inject it. Follow ...

  18. X-1A impact site

    NASA Technical Reports Server (NTRS)

    1955-01-01

    A photo taken on 8 August 1955, showing the remains of the Bell X-1A The Bell X-1A (Serial # 48-1384) was designed for aerodynamic stability and air load research. It was delivered to Edwards Air Force Base on 7 January 1953. The aircraft made its first glide flight on 14 February with Bell test pilot Jean 'Skip' Ziegler at the controls. Ziegler also flew the first powered flight in the X-1A on 21 February. Contractor flights in the aircraft continued through April, at which time the X-1A was temporarily grounded for modifications. Flight operations were resumed on 21 November 1953 with Maj. Charles 'Chuck' Yeager at the controls. During a flight on 12 December, Yeager took the X-1A to a record-breaking speed of Mach 2.44 at an altitude of 75,000 feet. He then encountered the unpleasant phenomemon of inertia coupling. The X-1A tumbled out of control, knocking Yeager unconscious briefly before entering an inverted spin. Fortunately Yeager regained his senses and control of the aircraft 60 miles from Edwards at an altitude of 25,000 feet. Shaken, but unharmed, he brought the rocket plane in for a safe landing on Rogers Dry Lake. Next, the X-1A was used for a series of high-altitude missions piloted by Maj. Arthur 'Kit' Murray. Fourteen flights proved necessary to meet the program requirements, with only four being successful. During the test series, Murray set several unofficial world altitude records. The highest (90,440 feet) was set on 26 August 1954. Following completion of the altitude program, the aircraft was turned over to the National Advisory Committee for Aeronautics (NACA). The X-1A underwent more modifications and was returned to flight status in July 1955. The first NACA-sponsored flight, piloted by Joseph A. Walker, took place on 20 July. The second NACA mission was to be the 25th flight of the X-1A. The flight began normally on 8 August 1955, with the X-1A shackled to the underside of a JTB-29A (45-21800) piloted by Stanley Butchart and John 'Jack' Mc

  19. 41 CFR 50-204.1a - Variances.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Variances. 50-204.1a... and Application § 50-204.1a Variances. (a) Variances from standards in this part may be granted in the same circumstances in which variances may be granted under sections 6(b)(6)(A) or 6(d) of the...

  20. Steroids Update, Part 1 and Part 2.

    ERIC Educational Resources Information Center

    Miller, Calvin; Duda, Marty

    1986-01-01

    Part 1 of this two-part article describes the views of a physician who believes that athletes who want to take steroids are best protected by receiving a prescription and monitoring. Part 2 discusses the more general view of physicians that steroids should not be prescribed but perhaps should be monitored. (MT)

  1. Differences in frequencies of UGT1A9, 1A7, and 1A1 genetic polymorphisms in Chinese Tibetan versus Han Chinese populations.

    PubMed

    Yan, W; Wang, Y W; Yang, F F; Wang, M; Zhang, X Q; Dong, J; Chen, E; Yang, J

    2013-01-01

    As part of a series of pharmacogenomics studies of the Chinese population, we investigated genetic polymorphisms of some UGT1A regions. The three genes that were analyzed were UGT1A9, 1A7, and 1A1; we sequenced their exons, together with promoters, surrounding introns and 3'-untranslated regions (3'UTR) in 100 unrelated-healthy Chinese Tibetan individuals. We compared the data with information on Han Chinese of the same region, which we downloaded from the HapMap database. We identified 40 polymorphisms; 16 of them were shared by the two populations. We then analyzed their linkage disequilibrium map. The UGT1As cluster can be divided into two linkage blocks in the Tibetan population: Block 1 (UGT1A9, UGT1A7), Block 2 (3'-UTR). Furthermore, we identified haplotypes and selected their tagSNPs. In exon 1 of UGT1A7 gene, 393G>A (Arg131Gln, rs17868324) was found at a frequency of 44.4% in the Tibetan population, compared to only 0.7% in the Han population. The linkage blocks in the Han Chinese sample differed from that of the Chinese Tibetan group; the former had Block 1 (UGT1A9, UGT1A7), Block 2 (UGT1A7), and Block 3 (3'-UTR). These findings provide fundamental information for future molecular genetic studies of the UGT1A gene cluster as well as for personalized medicine in Chinese. PMID:24390994

  2. Flowability of JSC-1a

    NASA Technical Reports Server (NTRS)

    Rame, Enrique; Wilkinson, Allen; Elliot, Alan; Young, Carolyn

    2009-01-01

    We have done a complete flowability characterization of the lunar soil simulant, JSC-1a, following closely the ASTM-6773 standard for the Schulze ring shear test. The measurements, which involve pre-shearing the material before each yield point, show JSC-1a to be cohesionless, with an angle of internal friction near 40 deg. We also measured yield loci after consolidating the material in a vibration table which show it to have significant cohesion (approximately equal to 1 kPa) and an angle of internal friction of about 60 deg. Hopper designs based on each type of flowability test differ significantly. These differences highlight the need to discern the condition of the lunar soil in the specific process where flowability is an issue. We close with a list not necessarily comprehensive of engineering rules of thumb that apply to powder flow in hoppers.

  3. Parts application handbook study

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The requirements for a NASA application handbook for standard electronic parts are determined and defined. This study concentrated on identifying in detail the type of information that designers and parts engineers need and expect in a parts application handbook for the effective application of standard parts on NASA projects.

  4. 7 CFR 1a.4 - Limitations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Limitations. 1a.4 Section 1a.4 Agriculture Office of the Secretary of Agriculture LAW ENFORCEMENT AUTHORITIES § 1a.4 Limitations. The powers granted by §§ 1a.2(a) and 1a.2(b) shall be exercised only when a designated official is engaged in an...

  5. 7 CFR 1a.4 - Limitations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Limitations. 1a.4 Section 1a.4 Agriculture Office of the Secretary of Agriculture LAW ENFORCEMENT AUTHORITIES § 1a.4 Limitations. The powers granted by §§ 1a.2(a) and 1a.2(b) shall be exercised only when a designated official is engaged in an...

  6. 7 CFR 1a.2 - Authorization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Authorization. 1a.2 Section 1a.2 Agriculture Office of the Secretary of Agriculture LAW ENFORCEMENT AUTHORITIES § 1a.2 Authorization. Any official of the Office of Inspector General who is designated by the Inspector General according to §§ 1a.3 and 1a.5...

  7. Measuring Populations, Part 2.

    ERIC Educational Resources Information Center

    Dillner, Harry

    This autoinstructional lesson dealing with the study of population growth is the second part of a two-part sequence. This is a learning activity for high school students who have completed Part 1 of "Measuring Populations" and are capable of using a microscope and of preparing slides to be observed. The behavioral objectives, both general and…

  8. 40 CFR Appendix A to Part 63 - Test Methods

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ....2.1A clearly written test method, preferably in the format of 40 CFR part 60, appendix A Test... reference from other methods in appendix A to 40 CFR part 60. Therefore, to obtain reliable results,...

  9. Parts-R-Us

    NASA Astrophysics Data System (ADS)

    Brunvand, Erik

    1987-12-01

    Parts-R-Us is a chip that contains a collection of building block parts for asynchronous circuit design. The parts contained on the chip are either not available as standard commercial components, or are standard gates combined into small modules that are particularly useful for building asynchronous control circuits. There are eight different configurations of Parts-R-Us, each offering a different set of asynchronous parts to the user. The parts contained on the chip include: C-elements, transition call modules, transition selectors, transition toggles, transition arbiters, a four phase mutual exclusion element, an asynchronous register, two phase Q-registers, and four phase Q-registers. This document is both a description of Parts-R-Us, and a user's manual for designers using the chip.

  10. Recent advances in wavelet analyses: Part 1. A review of concepts

    NASA Astrophysics Data System (ADS)

    Labat, David

    2005-11-01

    This contribution provides a review of the most recent wavelet applications in the field of earth sciences and is devoted to introducing and illustrating new wavelet analysis methods in the field of hydrology. Wavelet analysis remains unknown in the field of hydrology even though it clearly overcomes the well-known limits of the classical Fourier analysis. New wavelet-based tools are proposed to hydrologists in order to make wavelet analysis more attractive. First, a multiresolution continuous wavelet analysis method is shown to significantly improve the determination of the temporal-scale structure of a given signal. Second, the concept of wavelet entropy in both continuous and multiresolution frameworks is introduced allowing for an estimation of the temporal evolution of a given hydrological or climatologic signal's complexity. New insights in the scale-dependence of the relationship are exposed by introducing wavelet cross-correlation and wavelet coherence. Continuous wavelet cross-correlation provides a time-scale distribution of the correlation between two signals, whereas continuous wavelet coherence provides a qualitative estimator of the temporal evolution of the degree of linearity of the relationship between two signals on a given scale. These methods are applied to four large river runoffs and two global climatic indexes in a companion paper.

  11. Ontology Research and Development. Part 1-A Review of Ontology Generation.

    ERIC Educational Resources Information Center

    Ding, Ying; Foo, Schubert

    2002-01-01

    Discusses the role of ontology in knowledge representation, including enabling content-based access, interoperability, communications, and new levels of service on the Semantic Web; reviews current ontology generation studies and projects as well as problems facing such research; and discusses ontology mapping, information extraction, natural…

  12. Twenty-fourth Lunar and Planetary Science Conference. Part 1: A-F

    NASA Technical Reports Server (NTRS)

    1993-01-01

    The topics covered include the following: petrology, petrography, meteoritic composition, planetary geology, atmospheric composition, astronomical spectroscopy, lunar geology, Mars (planet), Mars composition, Mars surface, volcanology, Mars volcanoes, Mars craters, lunar craters, mineralogy, mineral deposits, lithology, asteroids, impact melts, planetary composition, planetary atmospheres, planetary mapping, cosmic dust, photogeology, stratigraphy, lunar craters, lunar exploration, space exploration, geochronology, tectonics, atmospheric chemistry, astronomical models, and geochemistry.

  13. The Twenty-Fifth Lunar and Planetary Science Conference. Part 1: A-G

    NASA Technical Reports Server (NTRS)

    1994-01-01

    Papers from the conference are presented, and the topics covered include the following: planetary geology, meteorites, planetary composition, meteoritic composition, planetary craters, lunar craters, meteorite craters, petrology, petrography, volcanology, planetary crusts, geochronology, geomorphism, mineralogy, lithology, planetary atmospheres, impact melts, volcanoes, planetary evolution, tectonics, planetary mapping, asteroids, comets, lunar soil, lunar rocks, lunar geology, metamorphism, chemical composition, meteorite craters, and planetary mantles.

  14. Morphology of the scattering targets: Fresnel and turbulent mechanisms, part 2.1A

    NASA Technical Reports Server (NTRS)

    Royrvik, O.

    1984-01-01

    Refractive index fluctuations cause coherent scattering and reflection of VHF radio waves from the clear air in the altitude region between 0 and approximately 90 km. Similar echoes from the stratosphere/troposphere and the mesosphere are observed at UHF and MF/HF frequencies, respectively. The nature of the refractive index fluctuations has been studied for many years without producing a clear consensus on what mechanism causes them. It is believed that the irregularities can originate from two different mechanisms: turbulent mixing of the gradient of refractive index, and stable horizontally stratified laminae of sharp gradients in the refractive index. In order to explain observations of volume dependence and aspect sensitivity of the echo power in the MST region, a diversity of submechanisms has been proposed. They include isotropic and anisotropic turbulent scattering, Fresnel scattering and reflection, and diffuse reflection. Isotropic turbulent scattering is believed to cause a majority of the clear air echoes observed by MST radars. The mechanism requires active turbulence mixing of a preexisting gradient in the refractive index profile.

  15. Porphyria Diagnostics – Part 1: A brief overview of the porphyrias

    PubMed Central

    Ramanujam, Vaithamanithi-Mudumbai Sadagopa; Anderson, Karl Elmo

    2015-01-01

    The porphyria diseases are a group of metabolic disorders caused by abnormal functioning of heme biosynthesis enzymes and characterized by the excessive accumulation and excretion of porphyrins and their precursors. Precisely which of these chemicals builds up depends on the type of porphyria. Porphyria is not a single disease but a group of nine disorders: acute intermittent porphyria (AIP), hereditary coproporphyria (HCP), variegate porphyria (VP), delta-aminolevelunic acid dehyratase deficiency porphyria (ADP), porphyria cutanea tarda (PCT), hepatoerythropoetic porphyria (HEP), congenital erythropoetic porphyria (CEP), erythropoetic protoporphyria (EPP), and X-linked protoporphyria (XLP). Each porphyria results from overproduction of heme precursors secondary to partial deficiency or, in XLP, increased activity of one of the enzymes of heme biosynthesis. Taken together, all forms of porphyria afflict fewer than 200,000 people in the United States. Based on European studies, the prevalence of the most common porphyria, PCT, is 1 in 10,000, the most common acute porphyria, AlP, is about 1 in 20,000, and the most common erythropoietic porphyria, EPP, is estimated at 1 in 50,000 to 75,000. CEP is extremely rare with prevalence estimates of 1 in 1,000,000 or less. Only 6 cases of ADP are documented. The current porphyria literature is very exhaustive and a brief overview of porphyria diseases is essential in order for the reader to better appreciate the relevance of this area of research prior to undertaking biochemical diagnostics procedures. This unit summarizes the current knowledge on the classification, clinical features, etiology, pathogenesis, and genetics of these porphyria diseases. PMID:26132003

  16. 50 CFR Table 1a to Part 679 - Delivery Condition* and Product Codes

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... gutted, Eastern cut. Head removed just behind the collar bone, and viscera removed 08 Headed and gutted... ONLY Soft shell crab 75 Bitter crab 76 Deadloss 79 Sections 80 Meat 81 Note: When using whole fish...

  17. Quips and Sentences and These Paper Bullets of the Brain. Part 1: A Contemplation of Critics.

    ERIC Educational Resources Information Center

    MacFarlane, Andrew

    A qualitative study of the validity of daily newspaper criticism, this report was based on the examination of the work of two competing critics and one relatively neutral cultural journalist covering four plays performed during the Stratford, Ontario, Shakespearean Festival. After examining the theoretical and philosophical context in which…

  18. Transcontinental methane measurements: Part 1. A mobile surface platform for source investigations

    NASA Astrophysics Data System (ADS)

    Farrell, Paige; Culling, Daniel; Leifer, Ira

    2013-08-01

    The potent greenhouse gas, methane, CH4, originates from a wide range of anthropogenic and natural sources. A ground-based, satellite-scale, transcontinental (Florida to California) survey was conducted to understand better emissions from key sources including wetlands, forest fire, and geologic sources, as well as to acquire desert background values and lower atmosphere vertical profiling in the San Bernardino Mountains. A total of 6600 measurements along 7020 km of roadways were made by flame ion detection, gas chromatography (GC) onboard a recreational vehicle in 2010, and during a second survey with a cavity ring-down spectrometer system in Southern California in 2012. Significant vibration reduction efforts allowed near continuous mobile GC measurements. Nocturnal CH4 measurements tended to be higher compared to daytime values, sometime significantly, for similar sources and were concluded due to day/night meteorological differences. The lowest GC observations were 1.80 ppm, observed in the California desert, ˜60 ppb less than minimum desert CH4 observed in 2012. Thanks to smoke visualization of a brush fire plume, the flux from the fire was estimated at 0.15 kiloton day-1. Geologic CH4 emissions from the La Brea tar pit and surrounding areas were surprisingly strong, with peak concentrations of nearly 50 ppm and highly elevated CH4 concentrations extending over at least ˜100 km2, and accounting potentially for a significant fraction of the LA basin CH4 emissions. Geologic CO2 emissions also were observed.

  19. Geophysical approaches to inverse problems: A methodological comparison. Part 1: A Posteriori approach

    NASA Technical Reports Server (NTRS)

    Seidman, T. I.; Munteanu, M. J.

    1979-01-01

    The relationships of a variety of general computational methods (and variances) for treating illposed problems such as geophysical inverse problems are considered. Differences in approach and interpretation based on varying assumptions as to, e.g., the nature of measurement uncertainties are discussed along with the factors to be considered in selecting an approach. The reliability of the results of such computation is addressed.

  20. Oxidative capacity of the Mexico City atmosphere - Part 1: A radical source perspective

    NASA Astrophysics Data System (ADS)

    Volkamer, R.; Sheehy, P.; Molina, L. T.; Molina, M. J.

    2010-07-01

    A detailed analysis of OH, HO2 and RO2 radical sources is presented for the near field photochemical regime inside the Mexico City Metropolitan Area (MCMA). During spring of 2003 (MCMA-2003 field campaign) an extensive set of measurements was collected to quantify time-resolved ROx (sum of OH, HO2, RO2) radical production rates from day- and nighttime radical sources. The Master Chemical Mechanism (MCMv3.1) was constrained by measurements of (1) concentration time-profiles of photosensitive radical precursors, i.e., nitrous acid (HONO), formaldehyde (HCHO), ozone (O3), glyoxal (CHOCHO), and other oxygenated volatile organic compounds (OVOCs); (2) respective photolysis-frequencies (J-values); (3) concentration time-profiles of alkanes, alkenes, and aromatic VOCs (103 compound are treated) and oxidants, i.e., OH- and NO3 radicals, O3; and (4) NO, NO2, meteorological and other parameters. The ROx production rate was calculated directly from these observations; the MCM was used to estimate further ROx production from unconstrained sources, and express overall ROx production as OH-equivalents (i.e., taking into account the propagation efficiencies of RO2 and HO2 radicals into OH radicals). Daytime radical production is found to be about 10-25 times higher than at night; it does not track the abundance of sunlight. 12-h average daytime contributions of individual sources are: Oxygenated VOC other than HCHO about 33%; HCHO and O3 photolysis each about 20%; O3/alkene reactions and HONO photolysis each about 12%, other sources <3%. Nitryl chloride photolysis could potentially contribute ~15% additional radicals, while NO2* + water makes - if any - a very small contribution (~2%). The peak radical production of ~7.5 107 molec cm-3 s-1 is found already at 10:00 a.m., i.e., more than 2.5 h before solar noon. O3/alkene reactions are indirectly responsible for ~33% of these radicals. Our measurements and analysis comprise a database that enables testing of the representation of radical sources and radical chain reactions in photochemical models. Since the photochemical processing of pollutants in the MCMA is radical limited, our analysis identifies the drivers for ozone and SOA formation. We conclude that reductions in VOC emissions provide an efficient opportunity to reduce peak concentrations of these secondary pollutants, because (1) about 70% of radical production is linked to VOC precursors; (2) lowering the VOC/NOx ratio has the further benefit of reducing the radical re-cycling efficiency from radical chain reactions (chemical amplification of radical sources); (3) a positive feedback is identified: lowering the rate of radical production from organic precursors also reduces that from inorganic precursors, like ozone, as pollution export from the MCMA caps the amount of ozone that accumulates at a lower rate inside the MCMA. Continued VOC reductions will in the future result in decreasing peak concentrations of ozone and SOA in the MCMA.

  1. T/R switch design for short-range measurements, part 6.1A

    NASA Technical Reports Server (NTRS)

    Yu, B.

    1984-01-01

    The positive intrinsic negative (PIN) diode switch which is designed to protect the receiver from burnout or damage on transmission and channel the echo signal to the receiver on reception is outlined. The receiver must be protected firmly. A schematic diagram of a transformer rectifier (TR-ATR) switch for the Urbana Radar is shown. The T/R switch consists of a half wavelength coaxial cavity with tuning condenser and PIN diodes. Two UM4300 PIN diodes were mounted between the inner and outer conductor. The dc biasing voltage required for the PIN diodes is supplied by a control circuit. On transmission, the PIN diodes are forward biased to about 0.5 amperes. On reception, about 10 volts reverse voltage is applied to the diodes, which produces an initial reverse current to speed the recovery time. The T/R switch characteristics are estimated and the result of testing at different peak transmitter powers from 410 kW to 1500 kW is shown.

  2. Frequency and site selection criteria for MST radars, part 5.1A

    NASA Technical Reports Server (NTRS)

    Nastrom, G. D.

    1984-01-01

    The majority of mesosphere-stratosphere-troposphere (MST) and ST radars are located in or near mountainous terrain. When measuring horizontal velocities, the terrain is a small factor, but when measuring vertical velocities, the meteorological noise induced by rough terrain can severely limit the usefulness of the observations. When the variance of the vertical velocity is too large, it is not possible to suitably filter the data to detect the small synoptic-scale signal with reasonable statistical confidence. The variance of vertical velocity at all tropospheric levels is directly related to the low level wind speed during flow over rough terrain. It is suggested that the synoptic-scale vertical velocity can be measured by ST radars where the terrain is smooth. The large-scale vertical velocity cannot always be reliably determined from MST radar data when the underlying terrain is rough. The vertical velocity is potentially on of future radar site selections, taking into account the desired meteorological applications of the data and engineering design factors. If the synoptic-scale vertical velocity is a desired variable, the radar should not be located near mountains.

  3. Coding schemes for improving MST radar performance, part 7.1A

    NASA Technical Reports Server (NTRS)

    Bowhill, S. A.

    1984-01-01

    The performance of an mesosphere-stratosphere-troposphere (MST) radar can be characterized by its system sensitivity and its range resolution. The former enables Doppler velocities to be determined even in the presence of very weak structures; the latter permits study of the fine structure within a turbulent region. Coding of transmitted signals has as its aim an increase in the effective radar sensitivity or range resolution without an increase in the peak transmitted power. This is accomplished by spreading the power in the frequency domain, giving better range resolution, without reducing the pulse width. Two basic techniques are used to accomplish this frequency dispersion: (1) using a type of pseudorandom code for the phase or amplitude within a single pulse, or within a finite sequence of pulses; (2) to code the frequency of the transmitted signal in some way. The various possibilities are discussed and are compared with the pulse-coding methods.

  4. Interactive dose shaping part 1: a new paradigm for IMRT treatment planning.

    PubMed

    Ziegenhein, Peter; Ph Kamerling, Cornelis; Oelfke, Uwe

    2016-03-21

    In this work we present a novel treatment planning technique called interactive dose shaping (IDS) to be employed for the optimization of intensity modulated radiation therapy (IMRT). IDS does not rely on a Newton-based optimization algorithm which is driven by an objective function formed of dose volume constraints on pre-segmented volumes of interest (VOIs). Our new planning technique allows for direct, interactive adaptation of localized planning features. This is realized by a dose modification and recovery (DMR) planning engine which implements a two-step approach: firstly, the desired localized plan adaptation is imposed on the current plan (modification) while secondly inevitable, undesired disturbances of the dose pattern elsewhere are compensated for automatically by the recovery module. Together with an ultra-fast dose update calculation method the DMR engine has been implemented in a newly designed 3D therapy planning system Dynaplan enabling true real-time interactive therapy planning. Here we present the underlying strategy and algorithms of the DMR based planning concept. The functionality of the IDS planning approach is demonstrated for a phantom geometry of clinical resolution and size. PMID:26948145

  5. Is Income Inequality a Determinant of Population Health? Part 1. A Systematic Review

    PubMed Central

    Lynch, John; Smith, George Davey; Harper, Sam; Hillemeier, Marianne; Ross, Nancy; Kaplan, George A; Wolfson, Michael

    2004-01-01

    This article reviews 98 aggregate and multilevel studies examining the associations between income inequality and health. Overall, there seems to be little support for the idea that income inequality is a major, generalizable determinant of population health differences within or between rich countries. Income inequality may, however, directly influence some health outcomes, such as homicide in some contexts. The strongest evidence for direct health effects is among states in the United States, but even that is somewhat mixed. Despite little support for a direct effect of income inequality on health per se, reducing income inequality by raising the incomes of the most disadvantaged will improve their health, help reduce health inequalities, and generally improve population health. PMID:15016244

  6. Adult-Rated Oceanography Part 1: A Project Integrating Ocean Sciences into Adult Basic Education Programs.

    NASA Astrophysics Data System (ADS)

    Cowles, S.; Collier, R.; Torres, M. K.

    2004-12-01

    Busy scientists seek opportunities to implement education and outreach efforts, but often don't know where to start. One easy and tested method is to form collaborations with federally-funded adult education and adult literacy programs. These programs exist in every U.S. state and territory and serve underrepresented populations through such major initiatives as adult basic education, adult secondary education (and GED preparation), and English language acquisition. These students are workers, consumers, voters, parents, grandparents, and members of every community. They have specific needs that are often overlooked in outreach activities. This presentation will describe the steps by which the Oregon Ocean Science and Math Collaborative program was developed. It is based on a partnership between the Oregon Department of Community Colleges and Workforce Development, Oregon State University College of Oceanic and Atmospheric Sciences, Oregon Sea Grant, and the OSU Hatfield Marine Science Center. It includes professional development through instructor institutes; teachers at sea and informal education opportunities; curriculum and web site development. Through the partnership described here, instructors in adult basic education programs participate in a yearlong experience in which they develop, test, and adapt innovative instructional strategies to meet the specific needs of adult learners. This, in turn, leads to new prospects for study in the areas of ocean science and math and introduces non-academic careers in marine science to a new community. Working directly with instructors, we have identified expertise level, instructional environment, instructor background and current teaching strategies used to address science literacy and numeracy goals of the adult learners in the State of Oregon. Preliminary evaluation of our ongoing project in meeting these goals will be discussed. These efforts contribute to national goals of science literacy for all, by providing learning activities that link ocean sciences with real-life issues relevant to employment, environment and economic concerns.

  7. Epistemic uncertainties and natural hazard risk assessment - Part 1: A review of the issues

    NASA Astrophysics Data System (ADS)

    Beven, K. J.; Aspinall, W. P.; Bates, P. D.; Borgomeo, E.; Goda, K.; Hall, J. W.; Page, T.; Phillips, J. C.; Rougier, J. T.; Simpson, M.; Stephenson, D. B.; Smith, P. J.; Wagener, T.; Watson, M.

    2015-12-01

    Uncertainties in natural hazard risk assessment are generally dominated by the sources arising from lack of knowledge or understanding of the processes involved. There is a lack of knowledge about frequencies, process representations, parameters, present and future boundary conditions, consequences and impacts, and the meaning of observations in evaluating simulation models. These are the epistemic uncertainties that can be difficult to constrain, especially in terms of event or scenario probabilities, even as elicited probabilities rationalized on the basis of expert judgements. This paper reviews the issues raised by trying to quantify the effects of epistemic uncertainties. Such scientific uncertainties might have significant influence on decisions that are made for risk management, so it is important to communicate the meaning of an uncertainty estimate and to provide an audit trail of the assumptions on which it is based. Some suggestions for good practice in doing so are made.

  8. Interactive dose shaping part 1: a new paradigm for IMRT treatment planning

    NASA Astrophysics Data System (ADS)

    Ziegenhein, Peter; Kamerling, Cornelis Ph; Oelfke, Uwe

    2016-03-01

    In this work we present a novel treatment planning technique called interactive dose shaping (IDS) to be employed for the optimization of intensity modulated radiation therapy (IMRT). IDS does not rely on a Newton-based optimization algorithm which is driven by an objective function formed of dose volume constraints on pre-segmented volumes of interest (VOIs). Our new planning technique allows for direct, interactive adaptation of localized planning features. This is realized by a dose modification and recovery (DMR) planning engine which implements a two-step approach: firstly, the desired localized plan adaptation is imposed on the current plan (modification) while secondly inevitable, undesired disturbances of the dose pattern elsewhere are compensated for automatically by the recovery module. Together with an ultra-fast dose update calculation method the DMR engine has been implemented in a newly designed 3D therapy planning system Dynaplan enabling true real-time interactive therapy planning. Here we present the underlying strategy and algorithms of the DMR based planning concept. The functionality of the IDS planning approach is demonstrated for a phantom geometry of clinical resolution and size.

  9. Porphyria Diagnostics-Part 1: A Brief Overview of the Porphyrias.

    PubMed

    Ramanujam, Vaithamanithi-Mudumbai Sadagopa; Anderson, Karl Elmo

    2015-01-01

    Porphyria diseases are a group of metabolic disorders caused by abnormal functioning of heme biosynthesis enzymes and characterized by excessive accumulation and excretion of porphyrins and their precursors. Precisely which of these chemicals builds up depends on the type of porphyria. Porphyria is not a single disease but a group of nine disorders: acute intermittent porphyria (AIP), hereditary coproporphyria (HCP), variegate porphyria (VP), δ-aminolevulinic acid dehydratase deficiency porphyria (ADP), porphyria cutanea tarda (PCT), hepatoerythropoietic porphyria (HEP), congenital erythropoietic porphyria (CEP), erythropoietic protoporphyria (EPP), and X-linked protoporphyria (XLP). Each porphyria results from overproduction of heme precursors secondary to partial deficiency or, in XLP, increased activity of one of the enzymes of heme biosynthesis. Taken together, all forms of porphyria afflict fewer than 200,000 people in the United States. Based on European studies, the most common porphyria, PCT, has a prevalence of 1 in 10,000, the most common acute porphyria, AlP, has a prevalence of ∼1 in 20,000, and the most common erythropoietic porphyria, EPP, is estimated at 1 in 50,000 to 75,000. CEP is extremely rare, with prevalence estimates of 1 in 1,000,000 or less. Only six cases of ADP are documented. The current porphyria literature is very exhaustive and a brief overview of porphyria diseases is essential in order for the reader to better appreciate the relevance of this area of research prior to undertaking biochemical diagnostics procedures. This unit summarizes the current knowledge on the classification, clinical features, etiology, pathogenesis, and genetics of porphyria diseases. PMID:26132003

  10. Oxidative capacity of the Mexico City atmosphere - Part 1: A radical source perspective

    NASA Astrophysics Data System (ADS)

    Volkamer, R.; Sheehy, P. M.; Molina, L. T.; Molina, M. J.

    2007-04-01

    A detailed analysis of OH, HO2 and RO2 radical sources is presented for the near field photochemical regime inside the Mexico City Metropolitan Area (MCMA). During spring of 2003 (MCMA-2003 field campaign) an extensive set of measurements was collected to quantify time resolved ROx (sum of OH, HO2, RO2) radical production rates from day- and nighttime radical sources. The Master Chemical Mechanism (MCMv3.1) was constrained by measurements of (1) concentration time-profiles of photosensitive radical precursors, i.e., nitrous acid (HONO), formaldehyde (HCHO), ozone (O3), glyoxal (CHOCHO), and other oxygenated volatile organic compounds (OVOCs); (2) respective photolysis-frequencies (J-values); (3) concentration time-profiles of alkanes, alkenes, and aromatic VOCs (103 compound are treated) and oxidants, i.e., OH- and NO3 radicals, O3; and (4) NO, NO2, meteorological and other parameters. The ROx production rate was calculated directly from these observations; MCM was used to estimate further ROx production from unconstrained sources, and express overall ROx production as OH-equivalents (i.e., taking into account the propagation efficiencies of RO2 and HO2 radicals into OH radicals). Daytime radical production is found to be about 10-25 times higher than at night; it does not track the abundance of sunlight. 12-h average daytime contributions of individual sources are: HCHO and O3 photolysis, each about 20%; O3/alkene reactions and HONO photolysis, each about 15%; unmeasured sources about 30%. While the direct contribution of O3/alkene reactions appears to be moderately small, source-apportionment of ambient HCHO and HONO identifies O3/alkene reactions as being largely responsible for jump-starting photochemistry about one hour after sunrise. The peak radical production is found to be higher than in any other urban influenced environment studied to date; further, differences exist in the timing of radical production. Our measurements and analysis comprise a database that enables testing of the representation of radical sources in photochemical models. Since the photochemical processing of pollutants is radical-limited in the MCMA, our analysis identifies the drivers for such processing. Three pathways are identified by which reductions in VOC emissions induce reductions in peak concentrations of secondary pollutants, such as O3 and secondary organic aerosol (SOA).

  11. Controlled parts management

    SciTech Connect

    Boyle, C. M.; Hidalgo, S. P.; Martinez, B. J.

    2004-01-01

    The Controlled Parts Management (CPM) system is based on industry standard practices for managing inventory. CPM is designed to record the movement of any type of inventory in a defined region referred to as an Account or SubAccount. The system is used to track the receiving, processing, storing and transfer of inventory parts. CPM provides information on parts, quantity and the exact location of the inventory. CPM is a barcode-based-part tracking system currently used to track controlled parts that are used in the R&D and testing of weapons; this tracking helps maintain the part pedigree that is required for certification of a weapon or weapon test. CPM includes bar code data collection software programmed into portable bar code readers for automating physical inventory services and remote transaction capture. CPM interfaces to other Engineering systems and supports a 'material content' of a weapons test through the test Bill of Materials and assignment of a unique inventory part in CPM. Additional functionality includes the ability to group or join parts, logically or physically and temporary or permanent, to represent discrete parts, containers, subassemblies and assemblies, and groupings.

  12. Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products.

    PubMed Central

    Harlow, E; Franza, B R; Schley, C

    1985-01-01

    Hybridomas secreting monoclonal antibodies specific for the adenovirus early region 1A (E1A) proteins were prepared from BALB/c mice immunized with a bacterial trpE-E1A fusion protein. This protein is encoded by a hybrid gene that joins a portion of the Escherichia coli trpE gene and a cDNA copy of the E1A 13S mRNA (Spindler et al., J. Virol. 49:132-141, 1984). Eighty-three hybridomas that secrete antibodies which recognize the immunogen were isolated and single cell cloned. Twenty-nine of these antibodies are specific for the E1A portion of the fusion protein. Only 12 of the monoclonal antibodies can efficiently immunoprecipitate E1A polypeptides from detergent lysates of infected cells. E1A polypeptides were analyzed on one-dimensional, sodium dodecyl sulfate-polyacrylamide gels and two-dimensional, isoelectric focusing polyacrylamide gels. The E1A proteins that are specifically immunoprecipitated by the monoclonal antibodies are heterogeneous in size and charge and can be resolved into approximately 60 polypeptide species. This heterogeneity is due not only to synthesis from multiple E1A mRNAs, but also at least in part to post-translational modification. Several of the monoclonal antibodies divide the E1A polypeptides into immunological subclasses based on the ability of the antibodies to bind to the antigen. In particular, two of the monoclonal antibodies bind to the polypeptides synthesized from the 13S E1A mRNA, but not to other E1A proteins. Images PMID:3894685

  13. Part-Time Faculty.

    ERIC Educational Resources Information Center

    Clery, Suzanne B.

    2001-01-01

    This study relates information regarding the role part-time faculty members fill in colleges and universities. Data are from the U.S. Department of Education's National Survey of Postsecondary Faculty, 1999. In that year, 2 of every 5 faculty members taught on a part-time basis, and they taught nearly 40% of all classes and students that were…

  14. Dissecting Diversity Part II

    ERIC Educational Resources Information Center

    Matthews, Frank

    2005-01-01

    This article presents "Dissecting Diversity, Part II," the conclusion of a wide-ranging two-part roundtable discussion on diversity in higher education. The participants were as follows: Lezli Baskerville, J.D., President and CEO of the National Association for Equal Opportunity (NAFEO); Dr. Gerald E. Gipp, Executive Director of the American…

  15. Holder for Fragile Parts

    NASA Technical Reports Server (NTRS)

    Holland, L. R.

    1983-01-01

    Fixture with many springfingers holds irregularly-shaped parts. Gripping fixture has hundreds of springfingers, each applies minute force. Total force approximates hydrostatic pressure, resulting in well-distributed load that maintains firm grip without high stress concentrations. Applied to industrial robot manipulators, fixutre enhances ability to grasp delicate parts.

  16. Microlabels For Auto Parts

    NASA Technical Reports Server (NTRS)

    Ash, John P.

    1993-01-01

    Proposed method of unique labeling and identification of automotive parts greatly simplifies recall campaigns and reduces effort and expense associated. Compressed symbols fully characterize each part by type and manufacturing history. Manufacturers notify only those owners whose cars need repairs or modifications. Similar compressed symbology developed for possible use on spacecraft.

  17. 29 CFR Appendix A to Part 1 - Appendix A to Part 1

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Appendix A to Part 1 A Appendix A to Part 1 Labor Office of the Secretary of Labor PROCEDURES FOR PREDETERMINATION OF WAGE RATES Pt. 1, App. A Appendix A to Part.... 779e(b)). 6. Library Services and Construction Act (sec. 7(a), 78 Stat. 13; 20 U.S.C. 355c(a)(4),...

  18. 29 CFR Appendix A to Part 1 - Appendix A to Part 1

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Appendix A to Part 1 A Appendix A to Part 1 Labor Office of the Secretary of Labor PROCEDURES FOR PREDETERMINATION OF WAGE RATES Pt. 1, App. A Appendix A to Part.... 779e(b)). 6. Library Services and Construction Act (sec. 7(a), 78 Stat. 13; 20 U.S.C. 355c(a)(4),...

  19. 40 CFR Table 1a to Subpart Dddd of... - Production-Based Compliance Options

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Production-Based Compliance Options 1A.... 63, Subpt. DDDD, Table 1A Table 1A to Subpart DDDD of Part 63—Production-Based Compliance Options For the following process units . . . You must meet the following production-based compliance...

  20. 9 CFR 73.1a - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false 73.1a Section 73.1a Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS SCABIES IN CATTLE § 73.1a...

  1. 9 CFR 73.1a - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false 73.1a Section 73.1a Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS SCABIES IN CATTLE § 73.1a...

  2. 9 CFR 73.1a - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false 73.1a Section 73.1a Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS SCABIES IN CATTLE § 73.1a...

  3. 9 CFR 73.1a - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false 73.1a Section 73.1a Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS SCABIES IN CATTLE § 73.1a...

  4. 9 CFR 73.1a - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false 73.1a Section 73.1a Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS SCABIES IN CATTLE § 73.1a...

  5. Fluoropolymers: Part I.

    ERIC Educational Resources Information Center

    Waller, F. J.

    1989-01-01

    Gives a brief account of fluoropolymers as an important part of polymer chemistry and attempts to make the topic relevant to the secondary school audience. Provides general characteristics and applications for fluoropolymers. (MVL)

  6. Affine Kac-Moody symmetric spaces related with A1^{(1)}, A2^{(1)},} A2^{(2)}

    NASA Astrophysics Data System (ADS)

    Nayak, Saudamini; Pati, K. C.

    2014-08-01

    Symmetric spaces associated with Lie algebras and Lie groups which are Riemannian manifolds have recently got a lot of attention in various branches of Physics for their role in classical/quantum integrable systems, transport phenomena, etc. Their infinite dimensional counter parts have recently been discovered which are affine Kac-Moody symmetric spaces. In this paper we have (algebraically) explicitly computed the affine Kac-Moody symmetric spaces associated with affine Kac-Moody algebras A1^{(1)}, A2^{(1)}, A2^{(2)}. We hope these types of spaces will play similar roles as that of symmetric spaces in many physical systems.

  7. Constitutive relations in TRAC-P1A

    SciTech Connect

    Rohatgi, U.S.; Saha, P.

    1980-08-01

    The purpose of this document is to describe the basic thermal-hydraulic models and correlations that are in the TRAC-P1A code, as released in March 1979. It is divided into two parts, A and B. Part A describes the models in the three-dimensional vessel module of TRAC, whereas Part B focuses on the loop components that are treated by one-dimensional formulations. The report follows the format of the questions prepared by the Analysis Development Branch of USNRC and the questionnaire has been attached to this document for completeness. Concerted efforts have been made in understanding the present models in TRAC-P1A by going through the FORTRAN listing of the code. Some discrepancies between the code and the TRAC-P1A manual have been found. These are pointed out in this document. Efforts have also been made to check the TRAC references for the range of applicability of the models and correlations used in the code. 26 refs., 5 figs., 1 tab.

  8. 40 CFR 57.809 - Ex parte communications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... body an ex parte communication relevant to the merits of the proceedings. (2) No member of the... member of the Agency trial staff an ex parte communication relevant to the merits of the proceedings. (b) Effect of receipt of ex parte communication. (1) A member of the decisional body who receives or...

  9. Adaptor Protein 1A Facilitates Dengue Virus Replication

    PubMed Central

    Yasamut, Umpa; Tongmuang, Nopprarat; Yenchitsomanus, Pa-thai; Junking, Mutita; Noisakran, Sansanee; Puttikhunt, Chunya; Chu, Justin Jang Hann; Limjindaporn, Thawornchai

    2015-01-01

    Rearrangement of membrane structure induced by dengue virus (DENV) is essential for replication, and requires host cellular machinery. Adaptor protein complex (AP)-1 is a host component, which can be recruited to components required for membrane rearrangement. Therefore, dysfunction of AP-1 may affect membrane organization, thereby decreasing replication of virus in infected cells. In the present study, AP-1-dependent traffic inhibitor inhibited DENV protein expression and virion production. We further clarified the role of AP-1A in the life cycle of DENV by RNA interference. AP-1A was not involved in DENV entry into cells. However, it facilitated DENV RNA replication. Viral RNA level was reduced significantly in Huh7 cells transfected with AP-1A small interfering RNA (siRNA) compared with control siRNA. Transfection of naked DENV viral RNA into Huh7 cells transfected with AP-1A siRNA resulted in less viral RNA and virion production than transfection into Huh7 cells transfected with control siRNA. Huh7 cells transfected with AP-1A siRNA showed greater modification of membrane structures and fewer vesicular packets compared with cells transfected with control siRNA. Therefore, AP-1A may partly control DENV-induced rearrangement of membrane structures required for viral replication. PMID:26090672

  10. 76 FR 66198 - Airworthiness Directives; Bombardier, Inc. Model BD-700-1A10 and BD-700-1A11 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-26

    ... parts. As we do not control warranty coverage for affected parties, some parties may incur costs higher... Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic... Directives; Bombardier, Inc. Model BD-700-1A10 and BD-700-1A11 Airplanes AGENCY: Federal...

  11. 78 FR 67291 - Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD-500-1A11 Series Airplanes; Design...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-12

    ..., 2000 (65 FR 19477- 19478), as well as at http://DocketsInfo.dot.gov/ . Docket: Background documents or... Administration 14 CFR Part 25 Special Conditions: Bombardier Inc., Models BD-500-1A10 and BD- 500-1A11 Series... Special Conditions; Request for Comments. SUMMARY: These special conditions are issued for the...

  12. Image registration by parts

    NASA Technical Reports Server (NTRS)

    Chalermwat, Prachya; El-Ghazawi, Tarek; LeMoigne, Jacqueline

    1997-01-01

    In spite of the large number of different image registration techniques, most of these techniques use the correlation operation to match spatial image characteristics. Correlation is known to be one of the most computationally intensive operations and its computational needs grow rapidly with the increase in the image sizes. In this article, we show that, in many cases, it might be sufficient to determine image transformations by considering only one or several parts of the image rather than the entire image, which could result in substantial computational savings. This paper introduces the concept of registration by parts and investigates its viability. It describes alternative techniques for such image registration by parts and presents early empirical results that address the underlying trade-offs.

  13. Plutonium microstructures. Part 1

    SciTech Connect

    Cramer, E.M.; Bergin, J.B.

    1981-09-01

    This report is the first of three parts in which Los Alamos and Lawrence Livermore National Laboratory metallographers exhibit a consolidated set of illustrations of inclusions that are seen in plutonium metal as a consequence of inherent and tramp impurities, alloy additions, and thermal or mechanical treatments. This part includes illustrations of nonmetallic and intermetallic inclusions characteristic of major impurity elements as an aid to identifying unknowns. It also describes historical aspects of the increased purity of laboratory plutonium samples, and it gives the composition of the etchant solutions and describes the etching procedure used in the preparation of each illustrated sample. 25 figures.

  14. Basic Electricity. Part 3.

    ERIC Educational Resources Information Center

    Kilmer, Donald C.

    Third (part 3) in a set of four guides designed for the student interested in a vocation in electrical work, this guide includes four units: Unit VI--Ohm's Law, covering six lessons (voltage, current-flow and resistance, the Ohm's Law formula, formula for finding voltage, formula for finding resistance); Unit VII--Voltages, covering five lessons…

  15. Basic Electricity. Part 2.

    ERIC Educational Resources Information Center

    Kilmer, Donald C.

    This guide, the second (part 2) in a set of four guides, is designed for the student interested in a vocation in electrical work, and includes two units: Unit IV--Electrical Theory, covering thirteen lessons (matter, the atom, electrical charges in the atom, rules of electric charges, electricity, atoms in an electrical conductor, electrical…

  16. Part-Time Employment.

    ERIC Educational Resources Information Center

    Guichard, Gus; And Others

    The employment of community college instructors on a part-time basis provides the opportunity for students to study under outstanding instructors whose primary employment may be in industry or in other postsecondary institutions and permits colleges to respond better to community needs with the financial resources available to them. Along with…

  17. Pieces and Parts

    ERIC Educational Resources Information Center

    Miller, Deborah A.; Ellis, Edith B.

    2006-01-01

    Although critical to understanding human sexuality and reproductive physiology, the male and female reproductive anatomy is often minimally covered by teachers. For teachers and students alike, it is often an embarrassing topic to discuss. This activity allows students and teachers to identify the parts of both reproductive systems with little…

  18. Meatcutting Testbook, Part 2.

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento. Bureau of Publications.

    This document contains objective tests for each topic in the Meatcutting Workbook, Part 2, which is designed for apprenticeship meatcutting programs in California. Each of the 30 tests consists of from 5 to 65 multiple-choice items with most tests containing approximately 10 items. The tests are grouped according to the eight units of the…

  19. Meatcutting Testbook, Part I.

    ERIC Educational Resources Information Center

    Strazicich, Mirko, Ed.

    This document contains objective tests for each lesson in the Meatcutting Workbook, Part I (see note), which is designed for apprenticeship programs in meatcutting in California. Each of the 36 tests contains from 10 to 45 multiple-choice items. The tests are grouped according to the eight units of the workbook: the apprentice meatcutter; applied…

  20. Auto Parts Testbook.

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento. Bureau of Industrial Education.

    This testbook contains objective (multiple choice) tests covering each topic in the companion Auto Parts Workbook (see note). The book is arranged so that each section can be detached and given to the student as the test subjects are covered in class. (Answers are not included.) There are an average of ten questions for each of six units. Unit A,…

  1. Auto Parts Workbook.

    ERIC Educational Resources Information Center

    California State Dept. of Education, Sacramento. Bureau of Industrial Education.

    This workbook is designed to provide the student apprentice in the auto parts trade with up-to-date knowledge and technical skills. The subject matter is organized into six units: (1) scope or background material, and employment opportunities in the field; (2) areas of responsibility, including shipping and filling orders, receiving, stock…

  2. Rockets -- Part II.

    ERIC Educational Resources Information Center

    Leitner, Alfred

    1982-01-01

    If two rockets are identical except that one engine burns in one-tenth the time of the other (total impulse and initial fuel mass of the two engines being the same), which rocket will rise higher? Why? The answer to this question (part 1 response in v20 n6, p410, Sep 1982) is provided. (Author/JN)

  3. Interferon Beta-1a Intramuscular Injection

    MedlinePlus

    ... symptoms flare up from time to time) of multiple sclerosis (MS, a disease in which the nerves do not ... known how interferon beta-1a works to treat MS. ... doctor.Interferon beta-1a controls the symptoms of MS but does not cure it. Continue to use ...

  4. Pharmacogenetics of SULT1A1

    PubMed Central

    Daniels, Jaclyn; Kadlubar, Susan

    2015-01-01

    Cytosolic SULT1A1 participates in the bioconversion of a plethora of endogenous and xenobiotic substances. Genetic variation in this important enzyme such as SNPs can vary by ethnicity and have functional consequences on its activity. Most SULT1A1 genetic variability studies have been centered on the SULT1A1*1/2 SNP. Highlighted here are not only this SNP, but other genetic variants associated with SULT1A1 that could modify drug efficacy and xenobiotic metabolism. Some studies have investigated how differential metabolism of xenobiotic substances influences susceptibility to or protection from cancer in multiple sites. This review will focus primarily on the impact of SULT1A1 genetic variation on the response to anticancer therapeutic agents and subsequently how it relates to environmental and dietary exposure to both cancer-causing and cancer-preventative compounds. PMID:25493573

  5. Concrete samples for organic samples, data package and 222-S validation summary report. Addendum 1A

    SciTech Connect

    Vogel, R.E.

    1994-11-01

    This document is in two parts: the first is the data package entitled ``Concrete Samples for Organic Samples`` and the second is entitled ``Concrete Samples for Organic Samples -- Addendum 1A`` which is the 222-S validation summary report.

  6. Just Perfect, Part 2

    ERIC Educational Resources Information Center

    Scott, Paul

    2007-01-01

    In "Just Perfect: Part 1," the author defined a perfect number N to be one for which the sum of the divisors d (1 less than or equal to d less than N) is N. He gave the first few perfect numbers, starting with those known by the early Greeks. In this article, the author provides an extended list of perfect numbers, with some comments about their…

  7. H5Part

    Energy Science and Technology Software Center (ESTSC)

    2005-12-01

    Particle based simulations of accelerator beam-lines, especially in six dimensional phase space, generate vast amounts of data. Even though a subset of statistical information regarding phase space or analysis needs to be preserved, reading and writing such enormous restart files on massively parallel supercomputing systems remains challenging. H5Part is a very simple data storage schema and provides an API that simplifies the reading/writing of the data to the HDF5 file format. An important foundation formore » a stable visualization and data analysis environment is a stable and portable file storage format and its associated APIs. The presence of a "common file storage format," including associated APIs, will help foster a fundamental level of interoperability across the project’s software infrastructure. It will also haip ensure that key data analysis capabilities are present during the earliest phases of the software development effort. H5Part is built on top of the HDF5 (Hierarchical Data Format). HDF5 offers a self.describing machine-independent binary file format that supports scalable parallel I/O performance for MPI codes on a variety of supercomputlng systems, and works equally well on laptop computers. The API Is available (or C, C++, and Fortran codes. The H5Part file format and APIs enable disparate research groups with different simulation implementations to transparently share datasets and data analysis tools. For instance, the common file format will enable groups that depend on completely different simulation implementations to share data analysis tools like PartView and AVS/Express without any additional programming.« less

  8. Plutonium microstructures, part 1

    NASA Astrophysics Data System (ADS)

    Cramer, E. M.; Bergin, J. B.

    1981-09-01

    Illustrations of inclusions that are seen in plutonium metal as a consequence of inherent and tramp impurities, alloy additions, and thermal or mechanical treatments are presented. This part includes illustrations of nonmetallic and intermetallic inclusions characteristic of major impurity elements as an aid to identifying unknowns are included. Historical aspects of the increased purity of laboratory plutonium samples are described and the composition of the etchant solutions are given. The etching procedure used in the preparation of each illustrated sample is described.

  9. Measurement of cylindrical parts

    NASA Astrophysics Data System (ADS)

    Knight, Paul Douglas, Jr.

    The form of cylindrical parts has been traditionally evaluated using stylus-based mechanical instruments. The Tropel Corporation has developed a grazing incidence interferometer (GII) for the measurement of cylindrical parts. The repeatability of this instrument due to various instrument uncertainties was measured. Differing instrument configurations that produce the same systematic error were determined to produce a zonal calibration method for determining systematic error over the full range of the instrument, given knowledge of the error in a single zone. The effect of the aperture stop on the response of the imaging system to axially sinusoidal artifacts was simulated. Diamond-turned axially sinusoidal artifacts, with amplitude of order1 um and spatial wavelength of order10 mm, were measured to test the axial response of the interferometer. The modulation transfer function of the instrument's imaging system, measured using a knife edge test, predicts the response observed with the sinusoidal artifacts. A diffraction analysis predicts that the measured axial form is modified by a second order envelope function with phase that varies with the relative position of the imaging system focal plane and part position. A compensation method is proposed for this effect. A comparison of roundness measurements by both a traditional stylus-based instrument and the GII was performed demonstrating that the roundness measurements of the two instruments are equivalent when the measurements are properly corrected for the differing effects of surface finish.

  10. The ZFHX1A Gene Is Differentially Autoregulated By Its Isoforms

    PubMed Central

    Manavella, Pablo A.; Roqueiro, Gonzalo; Darling, Douglas S.; Cabanillas, Ana M.

    2009-01-01

    The Zfhx1a gene expresses two different isoforms; the full length Zfhx1a-1 and a truncated isoform termed Zfhx1a-2 lacking the first exon. Deletion analysis of the Zfhx1a-1 promoter localized cell-specific repressors, and a proximal G-string that is critically required for transactivation. Transfection of Zfhx1a-1 cDNA, but not Zfhx1a -2, downregulates Zfhx1a-1 promoter activity. Mutation of an E2-box disrupted the binding of both Zfhx1a isoforms. Consistent with this, transfected Zfhx1a-1 does not regulate the transcriptional activity of the E-box mutated Zfhx1a-1 promoter. Competitive EMSAs and transfection assays show that Zfhx1a-2 can function as a dominant negative isoform since it is able to compete and displace Zfhx1a-1 from its binding site and overcome Zfhx1a-1 induced repression of the Zfhx1a-1 promoter in cells. Hence, the Zfhx1a-1 gene is autoregulated in part by negative feedback on its own promoter which is, in turn, modified by the availability of the negative dominant isoform Zfhx1a-2. PMID:17610840

  11. The ZFHX1A gene is differentially autoregulated by its isoforms.

    PubMed

    Manavella, Pablo A; Roqueiro, Gonzalo; Darling, Douglas S; Cabanillas, Ana M

    2007-08-31

    The Zfhx1a gene expresses two different isoforms; the full length Zfhx1a-1 and a truncated isoform termed Zfhx1a-2 lacking the first exon. Deletion analysis of the Zfhx1a-1 promoter localized cell-specific repressors, and a proximal G-string that is critically required for transactivation. Transfection of Zfhx1a-1 cDNA, but not Zfhx1a-2, downregulates Zfhx1a-1 promoter activity. Mutation of an E2-box disrupted the binding of both Zfhx1a isoforms. Consistent with this, transfected Zfhx1a-1 does not regulate the transcriptional activity of the E-box mutated Zfhx1a-1 promoter. Competitive EMSAs and transfection assays show that Zfhx1a-2 can function as a dominant negative isoform since it is able to compete and displace Zfhx1a-1 from its binding site and overcome Zfhx1a-1 induced repression of the Zfhx1a-1 promoter in cells. Hence, the Zfhx1a-1 gene is autoregulated in part by negative feedback on its own promoter which is, in turn, modified by the availability of the negative dominant isoform Zfhx1a-2. PMID:17610840

  12. The phenotype range of achondrogenesis 1A.

    PubMed

    Grigelioniene, Giedre; Geiberger, Stefan; Papadogiannakis, Nikos; Mäkitie, Outi; Nishimura, Gen; Nordgren, Ann; Conner, Peter

    2013-10-01

    Achondrogenesis 1A (ACG1A; OMIM 200600) is an autosomal recessive perinatally lethal skeletal dysplasia comprising intrauterine growth failure, micromelia, minor facial anomalies, deficient ossification of the skull, absent or extremely defective spinal ossification, short beaded ribs, and short deformed long bones with a stellate appearance. ACG1A is caused by mutations in the TRIP11 gene, resulting in deficiency of the Golgi microtubule associated protein 210. In this study we describe dizygotic twins with a clinical and radiological phenotype of ACG1A who were homozygous for a novel nonsense mutation in the TRIP11 gene. In addition, another patient with a milder manifestation, not readily distinguishable from those of other lethal skeletal dysplasias, was found to be a compound heterozygote for a nonsense mutation and a deletion of the 3' end of the TRIP11 gene. We conclude that mutations of the TRIP11 gene may encompass a wider phenotypic range than previously recognized. PMID:23956106

  13. Interferon Beta-1a Intramuscular Injection

    MedlinePlus

    ... course of disease where symptoms flare up from time to time) of multiple sclerosis (MS, a disease in which ... interferon beta-1a intramuscular at around the same time of day on your injection days. Follow the ...

  14. B-1a Lymphocytes Attenuate Insulin Resistance

    PubMed Central

    Shen, Lei; Chng, MH; Alonso, Michael N.; Yuan, Robert

    2015-01-01

    Obesity-associated insulin resistance, a common precursor of type 2 diabetes, is characterized by chronic inflammation of tissues, including visceral adipose tissue (VAT). Here we show that B-1a cells, a subpopulation of B lymphocytes, are novel and important regulators of this process. B-1a cells are reduced in frequency in obese high-fat diet (HFD)-fed mice, and EGFP interleukin-10 (IL-10) reporter mice show marked reductions in anti-inflammatory IL-10 production by B cells in vivo during obesity. In VAT, B-1a cells are the dominant producers of B cell–derived IL-10, contributing nearly half of the expressed IL-10 in vivo. Adoptive transfer of B-1a cells into HFD-fed B cell–deficient mice rapidly improves insulin resistance and glucose tolerance through IL-10 and polyclonal IgM-dependent mechanisms, whereas transfer of B-2 cells worsens metabolic disease. Genetic knockdown of B cell–activating factor (BAFF) in HFD-fed mice or treatment with a B-2 cell–depleting, B-1a cell–sparing anti-BAFF antibody attenuates insulin resistance. These findings establish B-1a cells as a new class of immune regulators that maintain metabolic homeostasis and suggest manipulation of these cells as a potential therapy for insulin resistance. PMID:25249575

  15. Distinción Empírica Entre Engagement y Trabajolismo en Enfermeras Hospitalarias de Japón: Efecto Sobre la Calidad del Sueño y el Desempeño Laboral

    PubMed Central

    Kubota, Kazumi; Shimazu, Akihito; Kawakami, Norito; Takahashi, Masaya; Nakata, Akinori; Schaufeli, Wilmar B.

    2016-01-01

    Objetivo El objetivo de este estudio es demostrar la distinción entre engagement y trabajolismo, estudiando su relación con la calidad del sueño y el desempeño laboral. Método Un total de 447 enfermeras de 3 hospitales de Japón fueron entrevistadas mediante un cuestionario autoadministrado que incluía la escala Utrecht (UWES, Utrecht Work Engagement Scale), la Escala de Adicción al Trabajo Holandesa (DUWAS, Dutch Workaholism Scale), preguntas sobre la calidad del sueño (7 ítems) con respecto a (1) dificultad para conciliar el sueño, (2) dificultad para mantener el sueño, (3) despertar temprano por la mañana, (4) dormirse o tomar siestas durante el día, (5) somnolencia diurna excesiva en el trabajo, (6) dificultad para despertarse por la mañana, y (7) despertar cansado en la mañana, y el Cuestionario sobre Salud y Desempeño (CSD) de la Organización Mundial de la Salud. Resultados Los modelos de ecuaciones estructurales demostraron que el engagement se relaciona positivamente con la calidad del sueño y el rendimiento laboral, mientras que el trabajolismo tiene una relación negativa con la calidad del sueño y el desempeño laboral. Conclusión Los resultados indican que el engagement y el trabajolismo son conceptualmente diferentes. El primero tiene una connotación positiva, mientras que el segundo se asocia de manera negativa al bienestar (buena calidad del sueño y buen rendimiento en el trabajo). PMID:26752805

  16. Copyright suit partly settled

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    Amidst continuing confusion on what constitutes ‘fair use’ photocopying of copyrighted material, the first legal action taken against an academic institution and individual professors for alleged violations of copyright law has been partly settled. Nine book publishers charged last December that New York University (NYU), several of its faculty, and an off-campus commercial photocopying establishment had violated copyright law. The action against NYU and its faculty was settled out of court. The portion of the lawsuit directed against Unique Copy Center will continue, however.

  17. 78 FR 69539 - Removal of Attestation Process for Facilities Using H-1A Registered Nurses

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ...=FR . SUPPLEMENTARY INFORMATION: In 1989, Congress created an H-1A nonimmigrant classification... implemented the H-1A program through regulations at 20 CFR part 655 Subparts D and E. See 55 FR 50500 (Dec. 6, 1990), as amended by 59 FR 874 (Jan. 6, 1994). Because of the expiration of the authorizing...

  18. 16 CFR Figure 2 to Part 1511 - Small Parts Gage

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Small Parts Gage 2 Figure 2 to Part 1511 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR PACIFIERS Pt.1511, Fig. 2 Figure 2 to Part 1511—Small Parts Gage EC03OC91.069...

  19. 16 CFR Figure 2 to Part 1511 - Small Parts Gage

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Small Parts Gage 2 Figure 2 to Part 1511 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR PACIFIERS Pt.1511, Fig. 2 Figure 2 to Part 1511—Small Parts Gage EC03OC91.069...

  20. 16 CFR Figure 2 to Part 1511 - Small Parts Gage

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Small Parts Gage 2 Figure 2 to Part 1511 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR PACIFIERS Pt.1511, Fig. 2 Figure 2 to Part 1511—Small Parts Gage EC03OC91.069...

  1. 16 CFR Figure 2 to Part 1511 - Small Parts Gage

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Small Parts Gage 2 Figure 2 to Part 1511 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR PACIFIERS Pt.1511, Fig. 2 Figure 2 to Part 1511—Small Parts Gage EC03OC91.069...

  2. 16 CFR Figure 2 to Part 1511 - Small Parts Gage

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Small Parts Gage 2 Figure 2 to Part 1511 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FEDERAL HAZARDOUS SUBSTANCES ACT REGULATIONS REQUIREMENTS FOR PACIFIERS Pt.1511, Fig. 2 Figure 2 to Part 1511—Small Parts Gage EC03OC91.069...

  3. UDP-glucuronosyltransferases 1A6 and 1A10 catalyze reduced menadione glucuronidation

    SciTech Connect

    Nishiyama, Takahito; Ohnuma, Tomokazu; Inoue, Yuu; Kishi, Takehiko; Ogura, Kenichiro; Hiratsuka, Akira

    2008-06-27

    Menadione (2-methyl-1,4-naphthoquine), also known as vitamin K3, has been widely used as a model compound in the field of oxidative stress-related research. The metabolism of menadione has been studied, and it is known that menadione undergoes a two-electron reduction by NAD(P)H:Quinone oxidoreductase 1 (NQO1) after which the reduced form of menadione (2-methyl-1,4-naphthalenediol, menadiol) is glucuronidated and excreted in urine. To investigate which human UDP-glucuronosyltransferase (UGT) isoforms participate in the glucuronidation of menadiol reduced by NQO1 from menadione, we first constructed heterologously expressed NQO1 in Sf9 cells and tested the menadiol glucuronidating activity of 16 human recombinant UGT isoforms. Of the 16 UGT isoforms, UGTs 1A6, 1A7, 1A8, 1A9, and 1A10 catalyzed menadiol glucuronidation, and, of these, UGTs 1A6 and 1A10 catalyzed menadiol glucuronidation at much higher rates than the other UGTs. Menadiol was regioselectively glucuronidated in the manner of 4-position > 1-position by UGTs 1A7, 1A8, 1A9, and 1A10. In contrast to these UGTs, only UGT1A6 exhibited 1-menadiol-preferential glucuronidating activity. The results suggest possible detoxification pathways for quinones via NQO1 reduction followed by UGT glucuronidation.

  4. 24 CFR Appendix A to Part 3500 - Instructions for Completing HUD-1 and HUD-1a Settlement Statements; Sample HUD-1 and HUD-1a...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Instructions for Completing HUD-1... and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  5. 24 CFR Appendix A to Part 3500 - Instructions for Completing HUD-1 and HUD-1a Settlement Statements; Sample HUD-1 and HUD-1a...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 5 2011-04-01 2011-04-01 false Instructions for Completing HUD-1... and Urban Development Regulations Relating to Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR HOUSING-FEDERAL HOUSING COMMISSIONER, DEPARTMENT OF HOUSING AND URBAN...

  6. Solving Quasars (Part 1)

    SciTech Connect

    Elvis, Martin

    2003-10-29

    Quasars are a frustratingly unsolved problem in astrophysics. For 40 years quasars and AGN have presented an ever-proliferating list of diverse and confusing phenomenology from optical to X-ray wavelengths. The result has been that despite being the most powerful objects in the universe, quasars have been increasingly sidelined in astrophysics. This is unfortunate, as quasars pose major physics, as well as astrophysics puzzles, and should be important in cosmology. The problem, I believe, is not that we do not know enough physics, but rather that we do not have the right geometry. I have proposed a simple geometric and kinematic model that allows all of the quasar diversity to be understood as part of a single structure, the 'Quasar Atmosphere'. This structure suggests a natural physical interpretation, that builds on our understanding of stars (the only fully solved problem in astrophysics), and offers the prospect that we can use quasars for cosmology at last.

  7. Electronic communication. Part III.

    PubMed

    Bergren, M D

    1995-02-01

    This is the concluding article of a three-part series on electronic communication for school nurses. The October 1994 column described electronic communication and the hardware and software required. The December 1994 column examined e-mail, bulletin boards, databases, and file transfers. This column will list many health and nursing resources available on-line. Some of the resources are available only through the Internet. Others are accessible by more than one route: dial-in, telnet, gopher, or world wide web. A few of the services, such as MEDLINE, are only accessed with purchased accounts (Glowniak & Bushway, 1994). The electronic resources of interest to school nurses are so numerous it would be impossible to cite all of them in a column of this length. Selected resources for the school health provider will be listed in alphabetical order. PMID:7767047

  8. DSCOVR_EPIC_L1A

    Atmospheric Science Data Center

    2015-09-29

    DSCOVR_EPIC_L1A Full sun-light Earth images calibrated with ... 680NM 688NM 551NM LAGRANGE L1B IMAGERY EPIC DSCOVR 325NM Order Data:  ASDC Order Tool: Order Data Readme Files:  EPIC Data Format Control Book Read Software Files :  ...

  9. Modeling Environment for Total Risk-1A

    EPA Science Inventory

    MENTOR-1A uses an integrated, mechanistically consistent source-to-dose modeling framework to quantify inhalation exposure and dose for individuals and/or populations due to co-occurring air pollutants. It uses the "One Atmosphere" concept to characterize simultaneous exposures t...

  10. Smoothed particle hydrodynamics with GRAPE-1A

    NASA Technical Reports Server (NTRS)

    Umemura, Masayuki; Fukushige, Toshiyuki; Makino, Junichiro; Ebisuzaki, Toshikazu; Sugimoto, Daiichiro; Turner, Edwin L.; Loeb, Abraham

    1993-01-01

    We describe the implementation of a smoothed particle hydrodynamics (SPH) scheme using GRAPE-1A, a special-purpose processor used for gravitational N-body simulations. The GRAPE-1A calculates the gravitational force exerted on a particle from all other particles in a system, while simultaneously making a list of the nearest neighbors of the particle. It is found that GRAPE-1A accelerates SPH calculations by direct summation by about two orders of magnitudes for a ten thousand-particle simulation. The effective speed is 80 Mflops, which is about 30 percent of the peak speed of GRAPE-1A. Also, in order to investigate the accuracy of GRAPE-SPH, some test simulations were executed. We found that the force and position errors are smaller than those due to representing a fluid by a finite number of particles. The total energy and momentum were conserved within 0.2-0.4 percent and 2-5 x 10 exp -5, respectively, in simulations with several thousand particles. We conclude that GRAPE-SPH is quite effective and sufficiently accurate for self-gravitating hydrodynamics.

  11. 14 CFR Appendix K to Part 121 - Performance Requirements for Certain Turbopropeller Powered Airplanes

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., and meets the additional airworthiness standards in SFAR No. 23 of 14 CFR part 23. iii. Normal... chapter. iv. Normal category, and complies with section 1.(a) or 1.(b) of SFAR No. 41 of 14 CFR part 21. b... in accordance with SFAR No. 41 of 14 CFR part 21, as described in paragraph 1.a.iv of this...

  12. 14 CFR Appendix K to Part 121 - Performance Requirements for Certain Turbopropeller Powered Airplanes

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., and meets the additional airworthiness standards in SFAR No. 23 of 14 CFR part 23. iii. Normal... chapter. iv. Normal category, and complies with section 1.(a) or 1.(b) of SFAR No. 41 of 14 CFR part 21. b... in accordance with SFAR No. 41 of 14 CFR part 21, as described in paragraph 1.a.iv of this...

  13. 16 CFR 1508.2 - Scope of part.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REQUIREMENTS FOR FULL-SIZE BABY CRIBS § 1508.2 Scope of part. This part sets forth the requirements whereby full-size baby cribs (as defined in § 1508.1(a)) are not banned articles under § 1500.18(a)(13) of...

  14. 16 CFR 1508.2 - Scope of part.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REQUIREMENTS FOR FULL-SIZE BABY CRIBS § 1508.2 Scope of part. This part sets forth the requirements whereby full-size baby cribs (as defined in § 1508.1(a)) are not banned articles under § 1500.18(a)(13) of...

  15. 40 CFR 57.809 - Ex parte communications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Effect of receipt of ex parte communication. (1) A member of the decisional body who receives or who... body an ex parte communication relevant to the merits of the proceedings. (2) No member of the decisional body shall make or knowingly cause to be made to any interested person outside the Agency...

  16. Individualized Instruction in Teacher Education. Part I and II.

    ERIC Educational Resources Information Center

    Fall, Charles; And Others

    This two-part manual for college teachers of education is designed to provide information about individualized instruction along with resources for teaching a unit on it. Part 1, a general introduction to individualized instruction in teacher education, contains discussion of background historical development in the area of independent study;…

  17. "Ask Argonne" - Robert Jacob, Climate Scientist, Part 2

    SciTech Connect

    Jacob, Robert

    2014-01-08

    Previously, climate scientist Robert Jacob talked a bit about the work he does and invited questions from the public during Part 1 of his "Ask Argonne" video set (http://bit.ly/1aK6WDv). In Part 2, he answers some of the questions that were submitted.

  18. "Ask Argonne" - Robert Jacob, Climate Scientist, Part 2

    ScienceCinema

    Jacob, Robert

    2014-11-24

    Previously, climate scientist Robert Jacob talked a bit about the work he does and invited questions from the public during Part 1 of his "Ask Argonne" video set (http://bit.ly/1aK6WDv). In Part 2, he answers some of the questions that were submitted.

  19. Managing Adjunct & Part-Time Faculty for the New Millennium.

    ERIC Educational Resources Information Center

    Greive, Donald E., Ed.; Worden, Catherine A., Ed.

    The contributions in this book address issues related to the management of part-time and adjunct college faculty members, including the impact of new technology, and provide information necessary for effective management in the future. The chapters are: (1) "A Vision of the Future--From the CEO" (Roy A. Church); (2) "Managing Adjunct and Part-Time…

  20. Cardiovascular Health, Part 2

    PubMed Central

    Baman, Timir S.; Gupta, Sanjaya; Day, Sharlene M.

    2010-01-01

    Context: An athlete’s health may be endangered if he or she continues to compete after diagnosis of certain cardiovascular conditions. The most worrisome risk is sudden cardiac death; the annual rate in US athletes is 1 in 50 000 to 200 000. Evidence Acquisition: Part 2 of this review highlights the current guidelines and controversies surrounding compatibility of participation with a variety of cardiac conditions in competitive and recreational athletics. Data sources were limited to peer-reviewed publications from 1984 to the April 2009. Results: The guidelines published by the American College of Cardiology and the European Society of Cardiology provide a framework for safe competitive and recreational sports participation in athletes with a broad spectrum of inherited and acquired cardiovascular disorders. These guidelines are necessarily conservative because it is not currently possible to individualize risk prediction. Few data are available in many areas, particularly in the noncompetitive arena or in older athletes. Conclusions: Published national guidelines are currently the foundation governing return-to-play decisions in athletes with cardiovascular conditions. Further studies are needed to refine risk stratification algorithms to allow athletes with cardiovascular conditions to reap the health benefits of regular exercise and sports participation without undue risk. PMID:23015920

  1. Procedural Safeguards under Part H: How Judicial Interpretations of Part B May Affect Part H.

    ERIC Educational Resources Information Center

    Turnbull, H. Rutherford, III; Turnbull, Ann P.

    1991-01-01

    This article compares and contrasts provisions for procedural safeguards and due process hearings under 2 sections of Public Law 99-457: Part B, dealing with children ages 3-5, and Part H, dealing with infants and toddlers. Potential problems under Part H are pointed out and suggestions are made for implementing Part H safeguards without conflict.…

  2. Central part of Pier 22, southwest part, showing the northwest ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Central part of Pier 22, southwest part, showing the northwest side of the Shore Power Supply Electric Distribution Center (Building 734) - Mare Island Naval Shipyard, Finger Piers 22 & 23, Railroad Avenue near Eighteenth Street, Vallejo, Solano County, CA

  3. Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice

    PubMed Central

    Lino, Noelia G.; González-Inchauspe, Carlota M. F.; González, Laura E.; Colettis, Natalia; Vattino, Lucas G.; Wunsch, Amanda M.; Wemmie, John A.; Uchitel, Osvaldo D.

    2013-01-01

    Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described to have a postsynaptic distribution in the brain, being involved not only in ischemia and epilepsy, but also in fear and psychiatric pathologies. High-frequency stimulation of skeletal motor nerve terminals (MNTs) can induce presynaptic pH changes in combination with an acidification of the synaptic cleft, known to contribute to muscle fatigue. Here, we studied the role of ASIC1a channels on neuromuscular transmission. We combined a behavioral wire hanging test with electrophysiology, pharmacological, and immunofluorescence techniques to compare wild-type and ASIC1a lacking mice (ASIC1a −/− knockout). Our results showed that 1) ASIC1a −/− female mice were weaker than wild type, presenting shorter times during the wire hanging test; 2) spontaneous neurotransmitter release was reduced by ASIC1a activation, suggesting a presynaptic location of these channels at individual MNTs; 3) ASIC1a-mediated effects were emulated by extracellular local application of acid saline solutions (pH = 6.0; HEPES/MES-based solution); and 4) immunofluorescence techniques revealed the presence of ASIC1a antigens on MNTs. These results suggest that ASIC1a channels might be involved in controlling neuromuscular transmission, muscle contraction and fatigue in female mice. PMID:24336653

  4. NASA Parts Program Office responsibilities

    NASA Technical Reports Server (NTRS)

    Kilroy, Patrick L.

    1994-01-01

    The topics are presented in viewgraph form and include the following: NASA Parts Program Office responsibilities; NASA Parts Project Office responsibilities; development priorities; and candidate functions for EPIMS baseline.

  5. 76 FR 17062 - Special Conditions: Bombardier Model BD-700-1A10 and BD-700-1A11 Airplanes, Head-Up Display (HUD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-28

    ... equivalent levels of safety. Although the pilot may readily be able to see around and through small..., which are spatially referenced to the pitch scale, outside view, and image, must be scaled and aligned... Federal Aviation Administration 14 CFR Part 25 Special Conditions: Bombardier Model BD-700-1A10 and...

  6. 76 FR 17582 - Special Conditions: Bombardier Model BD-700-1A10 and BD-700-1A11 Airplanes, Head-Up Display (HUD...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-30

    ... equivalent levels of safety. Although the pilot may readily be able to see around and through small... image and the HUD symbols, which are spatially referenced to the pitch scale, outside view, and image... Federal Aviation Administration 14 CFR Part 25 Special Conditions: Bombardier Model BD-700-1A10 and...

  7. 40 CFR Table 15 to Subpart Wwww of... - Applicability of General Provisions (Subpart A) to Subpart WWWW of Part 63

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... additional information . . . § 63.1(a)(1) General applicability of the general provisions Yes Additional... part, subpart WWWW of Part 63 takes precedence. § 63.1(a)(2) through (4) General applicability of the general provisions Yes § 63.1(a)(5) Reserved No § 63.1(a)(6) General applicability of the...

  8. 40 CFR Table 15 to Subpart Wwww of... - Applicability of General Provisions (Subpart A) to Subpart WWWW of Part 63

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... additional information . . . § 63.1(a)(1) General applicability of the general provisions Yes Additional... part, subpart WWWW of Part 63 takes precedence. § 63.1(a)(2) through (4) General applicability of the general provisions Yes § 63.1(a)(5) Reserved No § 63.1(a)(6) General applicability of the...

  9. INSAT-1A launch on Delta

    NASA Technical Reports Server (NTRS)

    1982-01-01

    The INSAT-1A, the first in a series of 12 transponder communications satellites developed for India, is described as well as the launch plans. The launch vehicle will be the Delta 3910 configuration which incorporates an extended long tank Thor booster, nine Castor IV strap-on motors, a TR-201 second stage, and an 8 foot fairing. The satellite will be placed in a suborbital trajectory. A DAM-D stage will then thrust it into a synchronous transfer orbit. An apogee kick motor will be fired to circularize its orbit at a geosynchronous altitude of 19,300 nautical miles.

  10. X-1A in flight over lakebed

    NASA Technical Reports Server (NTRS)

    1953-01-01

    The Bell Aircraft Corporation X-1A (48-1384) returning from an Air Force test flight over Edwards Air Force Base, California in late 1953. A North American F-86A Sabre as chase plane will follow the X-1A to touchdown. The Rogers Dry Lake is the whitish area under the planes with the airfield at the edge of the dry lake. Bell test pilot Jean 'Skip' Ziegler made six flights between 14 February and 25 April 1953. Air Force test pilots Maj. Charles 'Chuck' Yeager and Maj. Arthur 'Kit' Murray made 18 test flights between 21 November 1953 and 26 August 1954. NACA test pilot Joseph Walker made one successful flight on 20 July 1955. During a second flight attempt, on 8 August 1955, an explosion damaged the aircraft shortly before launch. Walker, unhurt, climbed up into the JTB-29A mothership, and the X-1A was jettisoned over the Edwards AFB bombing range. There were five versions of the Bell X-1 rocket-powered research aircraft that flew at the NACA High-Speed Flight Research Station, Edwards, California. The bullet-shaped X-1 aircraft were built by Bell Aircraft Corporation, Buffalo, N.Y. for the U.S. Army Air Forces (after 1947, U.S. Air Force) and the National Advisory Committee for Aeronautics (NACA). The X-1 Program was originally designated the XS-1 for EXperimental Sonic. The X-1's mission was to investigate the transonic speed range (speeds from just below to just above the speed of sound) and, if possible, to break the 'sound barrier.' Three different X-1s were built and designated: X-1-1, X-1-2 (later modified to become the X-1E), and X-1-3. The basic X-1 aircraft were flown by a large number of different pilots from 1946 to 1951. The X-1 Program not only proved that humans could go beyond the speed of sound, it reinforced the understanding that technological barriers could be overcome. The X-1s pioneered many structural and aerodynamic advances including extremely thin, yet extremely strong wing sections; supersonic fuselage configurations; control system

  11. Air Pollution. Part A: Analysis.

    ERIC Educational Resources Information Center

    Ledbetter, Joe O.

    Two facets of the engineering control of air pollution (the analysis of possible problems and the application of effective controls) are covered in this two-volume text. Part A covers Analysis, and Part B, Prevention and Control. (This review is concerned with Part A only.) This volume deals with the terminology, methodology, and symptomatology…

  12. Exploring Water Pollution. Part II

    ERIC Educational Resources Information Center

    Rillo, Thomas J.

    1975-01-01

    This is part two of a three part article related to the science activity of exploring environmental problems. Part one dealt with background information for the classroom teacher. Presented here is a suggested lesson plan on water pollution. Objectives, important concepts and instructional procedures are suggested. (EB)

  13. PREVENTION OF TYPE 1A DIABETES

    PubMed Central

    Eisenbarth, George S.

    2016-01-01

    Objective Review prediction of Type 1 diabetes in light of current trials for prevention and preclinical novel therapist. Methods We estimate from islet autoantibody testing of random cadaveric donors that approximately ½ million individuals in the United States express multiple islet autoantibodies and are developing Type 1A (immune mediated) diabetes. It is now possible to predict not only risk for Type 1A diabetes but also the approximate age of diabetes onset of children followed from birth. Results In animal models diabetes can be prevented and some of the immunologic therapies effective in animal models are able to delay loss of insulin secretion in man. Conclusion Unfortunately none of the therapies studied to date in man can completely arrest progressive loss of insulin secretion from destruction of islet beta cells. Nevertheless current knowledge of pathogenesis (targeting trimolecular recognition complex: MHC- peptide- T cell receptor) and natural history combined with newer diagnostic methods allows accurate diagnosis and has stimulated the search for novel safe and effective preventive therapies. PMID:22548954

  14. TRPA1: A Gatekeeper for Inflammation

    PubMed Central

    Bautista, Diana M.; Pellegrino, Maurizio; Tsunozaki, Makoto

    2014-01-01

    Tissue damage evokes an inflammatory response that promotes the removal of harmful stimuli, tissue repair, and protective behaviors to prevent further damage and encourage healing. However, inflammation may outlive its usefulness and become chronic. Chronic inflammation can lead to a host of diseases, including asthma, itch, rheumatoid arthritis, and colitis. Primary afferent sensory neurons that innervate target organs release inflammatory neuropeptides in the local area of tissue damage to promote vascular leakage, the recruitment of immune cells, and hypersensitivity to mechanical and thermal stimuli. TRPA1 channels are required for neuronal excitation, the release of inflammatory neuropeptides, and subsequent pain hypersensitivity. TRPA1 is also activated by the release of inflammatory agents from nonneuronal cells in the area of tissue injury or disease. This dual function of TRPA1 as a detector and instigator of inflammatory agents makes TRPA1 a gatekeeper of chronic inflammatory disorders of the skin, airways, and gastrointestinal tract. PMID:23020579

  15. Human TBK1: A Gatekeeper of Neuroinflammation.

    PubMed

    Ahmad, Liyana; Zhang, Shen-Ying; Casanova, Jean-Laurent; Sancho-Shimizu, Vanessa

    2016-06-01

    The importance of TANK binding kinase-1 (TBK1), a multimeric kinase that modulates inflammation and autophagy, in human health has been highlighted for the first time by the recent discoveries of mutations in TBK1 that underlie amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), normal tension glaucoma (NTG) or childhood herpes simplex encephalitis (HSE). Gain-of-function of TBK1 are associated with NTG, whereas loss-of-function mutations result in ALS/FTD or in HSE. In light of these new findings, we review the role of TBK1 in these seemingly unrelated, yet allelic diseases, and discuss the role of TBK1 in neuroinflammatory diseases. This discovery has the potential to significantly increase our understanding of the molecular basis of these poorly understood diseases. PMID:27211305

  16. Total syntheses of disulphated glycosphingolipid SB1a and the related monosulphated SM1a

    PubMed Central

    Hirose, Haruka; Tamai, Hideki; Gao, Chao; Imamura, Akihiro; Ando, Hiromune; Ishida, Hideharu; Feizi, Ten; Kiso, Makoto

    2016-01-01

    Total syntheses of two natural sulphoglycolipids, disulphated glycosphingolipid SB1a and the structurally related monosulphated SM1a, are described. They have common glycan sequences and ceramide moiety and are associated with human epithelial carcinomas. The syntheses featured efficient glycan assembly and the glucosyl ceramide cassette as a versatile building block. The binding of the synthetic sulphoglycolipids by the carcinoma-specific monoclonal antibody AE3 was investigated using carbohydrate microarray technology. PMID:26399908

  17. Rat Organic Anion Transporting Protein 1A1 (OATP1A1)

    PubMed Central

    Xiao, Yansen; Nieves, Edward; Angeletti, Ruth H.; Orr, George A.; Wolkoff, Allan W.

    2008-01-01

    Rat organic anion transporting protein 1a1 (oatp1a1), a hepatocyte basolateral plasma membrane protein, mediates transport of various amphipathic compounds. Our previous studies indicated that serine phosphorylation of a single tryptic peptide inhibits its transport activity without changing its cell surface content. The site of phosphorylation is unknown and was the subject of the present study. Following immunoaffinity chromatographic purification from rat liver, oatp1a1 was subjected to trypsin digestion and MALDI-TOF. Except for predicted N-glycosylated peptides, 97% of oatp1a1 tryptic peptides were observed. A single tryptic phosphopeptide was found in the C-terminus (aa 626-647), existing in unphosphorylated, singly, or doubly phosphorylated forms, and sensitive to alkaline phosphatase treatment. β-elimination reaction resulted in mass loss of 98 or 196 Da from this peptide, and subsequent Michael addition with cysteamine increased masses by the predicated 77 and 154 Da, indicating that oatp1a1 can be singly or doubly phosphorylated at serine or threonine residues in the C-terminal sequence SSATDHT (aa 634-640). Subsequent tandem MS/MS analysis revealed that phosphorylation at S634 accounted for all singly phosphorylated peptide, while phosphorylation at S634 and S635 accounted for all doubly phosphorylated peptide. These findings identify the site of oatp1a1 phosphorylation and demonstrate that it is an ordered process, in which phosphorylation at S634 precedes that at S635. The mechanism by which phosphorylation results in loss of transport activity in hepatocytes remains to be established. Whether phosphorylation near the C-terminus inhibits C-terminal oligomerization of oatp1a1, required for normal transport function, can be speculated upon, but is as yet unknown. PMID:16519530

  18. A study of LC-39 cryogenic systems. Part 1: A study of the vacuum insulated transfer lines at Kennedy Space Center. Part 2: Cooldown pressure surges

    NASA Technical Reports Server (NTRS)

    Ludtke, P. R.; Voth, R. O.

    1971-01-01

    The vacuum liquid hydrogen and liquid oxygen transfer lines at Kennedy Space Center were studied to evaluate the feasibility of using a condensing gas such as CO2 inside the vacuum spaces to achieve a condensing-vacuum. The study indicates that at ambient temperature, a maximum vacuum hyphen space pressure of 4000 microns is acceptable for the LH2 transfer lines. In addition, the cooldown procedures for the 14-inch cross-country liquid oxygen line was studied using a simplified mathematical model. Preliminary cooldown times are presented for various heat leak rates to the line and for two vent configurations.

  19. 45 CFR Appendix A to Part 13 - Appendix A to Part 13

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...); 1395bbb(c)(1); 1396b(m)(5)(B); 1396r(b)(3)(B)(ii), (g)(2)(A)(i); 1396t(i)(3); 11131(c); 11137(b)(2) 42 CFR... the recommendation of a Peer Review Organization 42 U.S.C. 1320c-5(b)(4), (5) 42 CFR part 1004; 42 CFR... or nonrenewals of Medicare provider agreements 42 U.S.C. 1395cc(h); 1395dd(d)(1)(A) 42 CFR...

  20. Lack of CYP1A responsiveness in species inhabiting chronically contaminated habitats: two varieties of resistance?

    PubMed

    Brammell, Ben F; Price, David J; Birge, Wesley J; Elskus, Adria A

    2013-03-01

    PCBs in a species within the family Ictaluridae and provides further support for our previous work indicating an apparent inherent lack of CYP1A sensitivity to chlorinated inducers in Centrarchids. These traits may explain, at least in part, the common association of these families with degraded habitats and indicate Lepomis members are likely to be excellent candidates for exploring the mechanistic basis of 'inherent' CYP1A resistance. This study also underlines to the need for thorough characterization of the CYP1A responsivity of a population and/or species prior to using CYP1A as a reliable biomonitoring tool. PMID:22776768

  1. The SNARE protein vti1a functions in dense-core vesicle biogenesis

    PubMed Central

    Walter, Alexander M; Kurps, Julia; de Wit, Heidi; Schöning, Susanne; Toft-Bertelsen, Trine L; Lauks, Juliane; Ziomkiewicz, Iwona; Weiss, Annita N; Schulz, Alexander; Fischer von Mollard, Gabriele; Verhage, Matthijs; Sørensen, Jakob B

    2014-01-01

    The SNARE protein vti1a is proposed to drive fusion of intracellular organelles, but recent data also implicated vti1a in exocytosis. Here we show that vti1a is absent from mature secretory vesicles in adrenal chromaffin cells, but localizes to a compartment near the trans-Golgi network, partially overlapping with syntaxin-6. Exocytosis is impaired in vti1a null cells, partly due to fewer Ca2+-channels at the plasma membrane, partly due to fewer vesicles of reduced size and synaptobrevin-2 content. In contrast, release kinetics and Ca2+-sensitivity remain unchanged, indicating that the final fusion reaction leading to transmitter release is unperturbed. Additional deletion of the closest related SNARE, vti1b, does not exacerbate the vti1a phenotype, and vti1b null cells show no secretion defects, indicating that vti1b does not participate in exocytosis. Long-term re-expression of vti1a (days) was necessary for restoration of secretory capacity, whereas strong short-term expression (hours) was ineffective, consistent with vti1a involvement in an upstream step related to vesicle generation, rather than in fusion. We conclude that vti1a functions in vesicle generation and Ca2+-channel trafficking, but is dispensable for transmitter release. PMID:24902738

  2. D-1A equipment module structure test

    NASA Technical Reports Server (NTRS)

    Niezgoda, T. F.

    1976-01-01

    The Centaur Equipment Module (E/M) structural test program was performed in two parts due to an unscheduled hardware failure in the first test series. The objectives of the initial test program were to define the flexibility characteristics of the E/M, verify the design load capability, and determine its ultimate strength capability by loading to structural failure. However, during the first failure test attempt, the Intelsat IV MPA failed instead of the E/M. Therefore a new adapter was fabricated to simulate the HEAO mission adapter and the second series of tests were then performed. They concluded with the failure of the E/M forward interface ring resulting in about 3.5 degrees of permanent set on the high compression side. Nevertheless, the linear or useable strength capability of the E/M is greater or equal to that which is required for the HEAO missions. The E/M is deemed structurally qualified for the HEAO missions.

  3. Heme Oxygenase-1: A Metabolic Nike

    PubMed Central

    Nemeth, Zsuzsanna; Correa-Costa, Matheus; Bulmer, Andrew C.; Otterbein, Leo E.

    2014-01-01

    Abstract Significance: Heme degradation, which was described more than 30 years ago, is still very actively explored with many novel discoveries on its role in various disease models every year. Recent Advances: The heme oxygenases (HO) are metabolic enzymes that utilize NADPH and oxygen to break apart the heme moiety liberating biliverdin (BV), carbon monoxide (CO), and iron. Heme that is derived from hemoproteins can be toxic to the cells and if not removed immediately, it causes cell apoptosis and local inflammation. Elimination of heme from the milieu enables generation of three products that influences numerous metabolic changes in the cell. Critical Issues: CO has profound effects on mitochondria and cellular respiration and other hemoproteins to which it can bind and affect their function, while BV and bilirubin (BR), the substrate and product of BV, reductase, respectively, are potent antioxidants. Sequestration of iron into ferritin and its recycling in the tissues is a part of the homeodynamic processes that control oxidation-reduction in cellular metabolism. Further, heme is an important component of a number of metabolic enzymes, and, therefore, HO-1 plays an important role in the modulation of cellular bioenergetics. Future Directions: In this review, we describe the cross-talk between heme oxygenase-1 (HO-1) and its products with other metabolic pathways. HO-1, which we have labeled Nike, the goddess who personified victory, dictates triumph over pathophysiologic conditions, including diabetes, ischemia, and cancer. Antioxid. Redox Signal. 20, 1709–1722. PMID:24180257

  4. Water Pollution: Part I, Municipal Wastewaters; Part II, Industrial Wastewaters.

    ERIC Educational Resources Information Center

    Fowler, K. E. M.

    This publication is an annotated bibliography of municipal and industrial wastewater literature. This publication consists of two parts plus appendices. Part one is entitled Municipal Wastewaters and includes publications in such areas as health effects of polluted waters, federal policy and legislation, biology and chemistry of polluted water,…

  5. Association between endometriosis and the interleukin 1A (IL1A) locus

    PubMed Central

    Sapkota, Yadav; Low, Siew-Kee; Attia, John; Gordon, Scott D.; Henders, Anjali K.; Holliday, Elizabeth G.; MacGregor, Stuart; Martin, Nicholas G.; McEvoy, Mark; Morris, Andrew P.; Takahashi, Atsushi; Scott, Rodney J.; Kubo, Michiaki; Zondervan, Krina T.; Montgomery, Grant W.; Nyholt, Dale R.

    2015-01-01

    STUDY QUESTION Are single-nucleotide polymorphisms (SNPs) at the interleukin 1A (IL1A) gene locus associated with endometriosis risk? SUMMARY ANSWER We found evidence for strong association between IL1A SNPs and endometriosis risk. WHAT IS KNOWN ALREADY Genetic factors contribute substantially to the complex aetiology of endometriosis and the disease has an estimated heritability of ∼51%. We, and others, have conducted genome-wide association (GWA) studies for endometriosis, which identified a total of nine independent risk loci. Recently, two small Japanese studies reported eight SNPs (rs6542095, rs11677416, rs3783550, rs3783525, rs3783553, rs2856836, rs1304037 and rs17561) at the IL1A gene locus as suggestively associated with endometriosis risk. There is also evidence of a link between inflammation and endometriosis. STUDY DESIGN, SIZE, DURATION We sought to further investigate the eight IL1A SNPs for association with endometriosis using an independent sample of 3908 endometriosis cases and 8568 controls of European and Japanese ancestry. The study was conducted between October 2013 and July 2014. PARTICIPANTS/MATERIALS, SETTING, METHODS By leveraging GWA data from our previous multi-ethnic GWA meta-analysis for endometriosis, we imputed variants in the IL1A region, using a recent 1000 Genomes reference panel. After combining summary statistics for the eight SNPs from our European and Japanese imputed data with the published results, a fixed-effect meta-analysis was performed. An additional meta-analysis restricted to endometriosis cases with moderate-to-severe (revised American Fertility Society stage 3 or 4) disease versus controls was also performed. MAIN RESULTS AND THE ROLE OF CHANCE All eight IL1A SNPs successfully replicated at P < 0.014 in the European imputed data with concordant direction and similar size to the effects reported in the original Japanese studies. Of these, three SNPs (rs6542095, rs3783550 and rs3783525) also showed association with

  6. Mapping ionospheric backscatter measured by the SuperDARN HF radars - Part 1: A new empirical virtual height model

    NASA Astrophysics Data System (ADS)

    Chisham, G.; Yeoman, T. K.; Sofko, G. J.

    2008-05-01

    Accurately mapping the location of ionospheric backscatter targets (density irregularities) identified by the Super Dual Auroral Radar Network (SuperDARN) HF radars can be a major problem, particularly at far ranges for which the radio propagation paths are longer and more uncertain. Assessing and increasing the accuracy of the mapping of scattering locations is crucial for the measurement of two-dimensional velocity structures on the small and meso-scale, for which overlapping velocity measurements from two radars need to be combined, and for studies in which SuperDARN data are used in conjunction with measurements from other instruments. The co-ordinates of scattering locations are presently estimated using a combination of the measured range and a model virtual height, assuming a straight line virtual propagation path. By studying elevation angle of arrival information of backscatterred signals from 5 years of data (1997-2001) from the Saskatoon SuperDARN radar we have determined the actual distribution of the backscatter target locations in range-virtual height space. This has allowed the derivation of a new empirical virtual height model that allows for a more accurate mapping of the locations of backscatter targets.

  7. Test design description for the Fusion Materials Open Test Assembly (Fusion MOTA-2A): Volume 1A, Part 1

    SciTech Connect

    Bauer, R.E.

    1988-11-01

    This document encompasses the test requirements, hardware design, fabrication, and safety analysis for the Fusion Materials Open Test Assembly experiment for irradiation in FFTF Cycle 11 (Fusion MOTA-2A). Fusion MOTA is equally shared by the US Fusion Material (DOE), Japanese Fusion Materials (MONBUSHO), and BEATRIX-II (IEA) programs. In the interest of providing optimum use of the irradiation space in the Fusion MOTA-2A and LMR MOTA-1G, eight of the Fusion MOTA canisters will be placed in MOTA-1G and an equal number of LMR canisters placed in Fusion MOTA-2A (Powell/Doran 1988). This eliminates the need to process Fusion MOTA-2A through the IEM cell prior to insertion for FFTF Cycle 11A. The LMR MOTA design and safety analysis (Greenslade 1984) is the basis for much of this design and safety analysis report. This design description and safety analysis for the Fusion MOTA-2A is presented per the outline given in Chapter IV of the FTR User`s Guide (Taylor 1978). 35 refs., 17 figs., 9 tabs.

  8. Current distribution in a three-dimensional IC analyzed by a perturbation method. Part 1: A simple steady state theory

    NASA Technical Reports Server (NTRS)

    Edmonds, Larry D.

    1987-01-01

    The steady state current distribution in a three dimensional integrated circuit is presented. A device physics approach, based on a perturbation method rather than an equivalent lumped circuit approach, is used. The perturbation method allows the various currents to be expressed in terms of elementary solutions which are solutions to very simple boundary value problems. A Simple Steady State Theory is the subtitle because the most obvious limitation of the present version of the analysis is that all depletion region boundary surfaces are treated as equipotential surfaces. This may be an adequate approximation in some applications but it is an obvious weakness in the theory when applied to latched states. Examples that illustrate the use of these analytical methods are not given because they will be presented in detail in the future.

  9. Hybrid clustering based fuzzy structure for vibration control - Part 1: A novel algorithm for building neuro-fuzzy system

    NASA Astrophysics Data System (ADS)

    Nguyen, Sy Dzung; Nguyen, Quoc Hung; Choi, Seung-Bok

    2015-01-01

    This paper presents a new algorithm for building an adaptive neuro-fuzzy inference system (ANFIS) from a training data set called B-ANFIS. In order to increase accuracy of the model, the following issues are executed. Firstly, a data merging rule is proposed to build and perform a data-clustering strategy. Subsequently, a combination of clustering processes in the input data space and in the joint input-output data space is presented. Crucial reason of this task is to overcome problems related to initialization and contradictory fuzzy rules, which usually happen when building ANFIS. The clustering process in the input data space is accomplished based on a proposed merging-possibilistic clustering (MPC) algorithm. The effectiveness of this process is evaluated to resume a clustering process in the joint input-output data space. The optimal parameters obtained after completion of the clustering process are used to build ANFIS. Simulations based on a numerical data, 'Daily Data of Stock A', and measured data sets of a smart damper are performed to analyze and estimate accuracy. In addition, convergence and robustness of the proposed algorithm are investigated based on both theoretical and testing approaches.

  10. The Coronal Plane High Tibial Osteotomy. Part 1: A Clinical and Radiographic Analysis of Intermediate Term Outcomes

    PubMed Central

    Fealy, Stephen; Lyman, Stephen; Wickiewicz, Thomas L.

    2007-01-01

    The coronal plane high tibial osteotomy is a novel technique that is used to treat tibiofemoral malalignment. The authors hypothesize that the coronal plane high tibial osteotomy is (1) efficacious in treating both varus and valgus tibiofemoral malalignment; (2) does not alter the slope of the proximal tibia; and (3) does not alter the relationship between the patella and tibial tubercle. A retrospective review of 25 patients with tibiofemoral malalignment (19 varus/6 valgus) treated with a coronal plane osteotomy with a minimum of 2-year follow-up was performed. A Kaplan–Meyer survival curve was performed using knee arthroplasty and a Hospital for Special Surgery (HSS) knee score <70 as failure criteria. The Insall–Salvati ratio and the proximal tibial slope were measured. A p value of 0.05 was considered significant. At 60-month follow-up, knees with initial varus malalignment had an 84% survival rate using both knee arthroplasty and the HSS score as endpoints. Knees with initial valgus malalignment had an 84 and 60% survival rate using knee arthroplasty and the HSS score as endpoints, respectively. There was no statistically significant change in the Insall–Salvati ratio and proximal tibial slope after coronal plane osteotomy. The coronal plane osteotomy is efficacious in treating varus and valgus tibiofemoral malalignment and does not alter the patellar–tibial tubercle relationship or the posterior tibial slope [case series (level of evidence: IV)]. PMID:18751785

  11. The potential of pulse-jet baghouses for utility boilers. Part 1: A worldwide survey of users

    SciTech Connect

    Belba, V.H. ); Grubb, W.T. ); Chang, R. )

    1992-02-01

    Pulse-jet fabric filters (PJFFs) are widely used in US industrial boiler applications and in utility and industrial boilers abroad. Their smaller size and reduced cost relative to more conventional baghouses make PJFFs appear to be a particularly attractive particulate control option for utility boilers. This paper summarizes the results of a survey co-funded by the Electric Power Research Institute and Canadian Electric Association to characterize the performance of and operating experiences with PJFFs applied to coal-fired boilers. The survey involved site visits to interview technical and plant personnel involved in the design, installation and day-to-day operation of PJFFs worldwide. Actual field experiences with PJFF performance in terms of outlet emissions, pressure drop and bag life for different types of pulse-jet cleaning methods, fabrics and boilers are compared.

  12. How relevant is the deposition of mercury onto snowpacks? - Part 1: A statistical study on the impact of environmental factors

    NASA Astrophysics Data System (ADS)

    Durnford, D. A.; Dastoor, A. P.; Steen, A. O.; Berg, T.; Ryzhkov, A.; Figueras-Nieto, D.; Hole, L. R.; Pfaffhuber, K. A.; Hung, H.

    2012-01-01

    A portion of the highly toxic methylmercury that bioaccumulates in aquatic life is created from mercury entering bodies of water with snowpack meltwater. To determine the importance of meltwater as a source of aquatic mercury, it is necessary to understand the environmental processes that govern the behavior of snowpack-related mercury. In this study we investigate relationships among 5 types of snowpack-related mercury observations and 20 model environmental variables. The observation types are the 24-h fractional loss of mercury from surface snow, and the concentrations of mercury in surface snow, seasonal snowpacks, the snowpack meltwater's ionic pulse, and long-term snowpack-related records. The model environmental variables include those related to atmospheric mercury, insolation, wind, atmospheric stability, snowpack physical characteristics, atmospheric pressure, and solid precipitation. Correlation coefficients and multiple linear regressions were calculated twice: once with all observations, and once with observations from locations presumably affected by oxidizing and stabilizing snowpack-related halogens excluded. We find that the presence of snowpack-related halogens has a significant impact on the behavior of snowpack-related mercury. Physically, snowpack-related mercury observations are most strongly controlled by the dry and wet depositions of oxidized mercury. The burial of mercury by fresh snowfalls and the wind driven ventilation of snowpacks are important processes. Indeed, in the absence of snowpack-related halogens, the 24-h fractional loss of mercury from surface snow is fully controlled by mercury deposition and surface-level atmospheric wind speed, stability, and surface pressure. The concentration of mercury in long-term records is affected by latitude, ventilation and surface pressure.

  13. Distal radius fixation through a mini-invasive approach of 15 mm. PART 1: a series of 144 cases.

    PubMed

    Lebailly, Frédéric; Zemirline, Ahmed; Facca, Sybille; Gouzou, Stéphanie; Liverneaux, Philippe

    2014-08-01

    The volar Henry approach is becoming the gold standard for distal radius fracture fixation. It decreases the incidence of nonunion, limits complications especially complex regional pain syndrome (CRPS) type I, and allows early mobilization of the wrist. Nonetheless, it has some disadvantages such as the size of the incision, which is not esthetically pleasing, and the loss of ligamentotaxis. This is why some authors have developed a mini-invasive approach. The aim of this work was to evaluate the feasibility of the anterior mini-invasive approach of 15 mm in a clinical series of 144 cases of distal radius fracture. All patients were operated under regional anesthesia using the same techniques by five surgeons of the same team. According to the AO classification, there were 83 type A fractures, 2 type B, and 59 type C. A volar plate (Step One(®), Newclip Technics™, Haute-Goulaine, France) was used in all cases. The 2 proximal metaphyseal screws and the 2 distal central epiphyseal screws were monoaxial locking. The 2 distal ulnar and radial epiphyseal screws were placed in polyaxial locking at 20° angulation maximum. Skin closure without drainage was performed. No postoperative immobilization was prescribed, and patients were encouraged to use their upper limb immediately postoperative. No postoperative physiotherapy was prescribed. The mean follow-up was 4.1 months. The final size of the incision was on average 16.1 mm. Mean pain score was 1.8. The Quick DASH score was average 25. Average range of motion was more than 85 %, and global force of the hand was 67 % compared with contralateral side. On X-ray, the mean radial slope was 22°, the mean radial tilt was 8.3°, and the mean radioulnar variance/index was -0.4 mm. There were nine cases of CRPS type I, which all resolved. Specific complications included two secondary displacements and nine tenosynovitis cases. No tendon rupture was noted. Two intra-articular distal radioulnar joint screws had to be removed at 3 months. One epiphyseal screw required removal 1 month postoperative due to loosening. There were no intra-articular radiocarpal screws. Distal radius fracture fixation using a mini-invasive approach is a reliable and reproducible procedure with few complications. It allows anatomical reduction in the distal radius fractures including intra-articular ones. It can be associated with arthroscopy, scaphoid screw fixation or even percutaneous pinning. Thus, most traumatic lesions of the wrist bony or soft tissue can be treated through this mini-invasive approach. PMID:24258689

  14. Microbial carbon recycling - an underestimated process controlling soil carbon dynamics - Part 1: A long-term laboratory incubation experiment

    NASA Astrophysics Data System (ADS)

    Basler, A.; Dippold, M.; Helfrich, M.; Dyckmans, J.

    2015-10-01

    Independent of its chemical structure carbon (C) persists in soil for several decades, controlled by stabilization and recycling. To disentangle the importance of the two factors on the turnover dynamics of soil sugars, an important compound of soil organic matter (SOM), a 3-year incubation experiment was conducted on a silty loam soil under different types of land use (arable land, grassland and forest) by adding 13C-labelled glucose. The compound-specific isotope analysis of soil sugars was used to examine the dynamics of different sugars during incubation. Sugar dynamics were dominated by a pool of high mean residence times (MRT) indicating that recycling plays an important role for sugars. However, this was not substantially affected by soil C content. Six months after label addition the contribution of the label was much higher for microbial biomass than for CO2 production for all examined land use types, corroborating that substrate recycling was very effective within the microbial biomass. Two different patterns of tracer dynamics could be identified for different sugars: while fucose and mannose showed highest label contribution at the beginning of the incubation with a subsequent slow decline, galactose and rhamnose were characterized by slow label incorporation with subsequently constant levels, which indicates that recycling is dominating the dynamics of these sugars. This may correspond to (a) different microbial growing strategies (r and K-strategist) or (b) location within or outside the cell membrane (lipopolysaccharides vs. exopolysaccharides) and thus be subject of different re-use within the microbial food web. Our results show how the microbial community recycles substrate very effectively and that high losses of substrate only occur during initial stages after substrate addition. This study indicates that recycling is one of the major processes explaining the high MRT observed for many SOM fractions and thus is crucial for understanding the global soil C cycle.

  15. Judicious use of prophylactic antimicrobials to reduce abdominal surgical site infections in periparturient cows: part 1 - a risk factor review.

    PubMed

    Dumas, S E; French, H M; Lavergne, S N; Ramirez, C R; Brown, L J; Bromfield, C R; Garrett, E F; French, D D; Aldridge, B M

    2016-06-25

    Surgical site infections (SSI) are an uncommon, but significant, consequence of surgical interventions. There are very few studies investigating SSI risk in veterinary medicine, and even fewer in cattle, despite the fact that major surgeries are commonly conducted on livestock. Furthermore, the suboptimal conditions under which such surgeries are frequently performed on livestock could be considered an important risk factor for the development of SSIs. With increasing public concern over the contribution of veterinary-prescribed antimicrobials to the emergence of antimicrobial-resistant bacteria in people, there is widespread scrutiny and criticism of antimicrobial use in livestock production medicine systems. While the causal link between antimicrobial resistance in livestock and people is heavily debated, it is clear that the prevalence of antimicrobial resistance, in any population, is closely correlated with the antimicrobial 'consumption' within that population. As the veterinary profession explores ways of addressing the emergence and selection of antimicrobial-resistant bacteria in food-producing animals, there is a need for veterinarians and producers to carefully consider all areas of antimicrobial use, and employ an evidence-based approach in designing appropriate clinical protocols. This paper aims to review current knowledge regarding the risk factors related to abdominal SSI in periparturient cows, and to encourage practitioners to judiciously evaluate both their standard operating procedures and their use of antimicrobials in these situations. In a second paper, to be published in a subsequent issue of Veterinary Record, these principles will be used to provide specific evidence-based recommendations for antimicrobial use in bovine abdominal surgery. PMID:27339926

  16. Diagnosing the average spatio-temporal impact of convective systems - Part 1: A methodology for evaluating climate models

    NASA Astrophysics Data System (ADS)

    Johnston, M. S.; Eriksson, P.; Eliasson, S.; Zelinka, M. D.; Forbes, R. M.; Wyser, K.

    2013-05-01

    A~method to determine the mean response of upper tropospheric water to localised deep convective (DC) events is improved and applied to the EC-Earth climate model. Following Zelinka and Hartmann (2009), several fields related to moist processes and radiation are composited with respect to local maxima in rain rate to determine their spatio-temporal evolution with deep convection in the central Pacific Ocean. Major improvements to the above study are the isolation of DC events in time so as to prevent multiple sampling of the same event, and a revised definition of the mean background state that allows for better characterization of the DC-induced anomalies. The DC events observed in this study propagate westward at ~ 4 m s-1. Both the upper tropospheric relative humidity and outgoing longwave radiation are substantially perturbed over a broad horizontal extent during peak convection and for long periods of time. Cloud fraction anomaly increases throughout the upper troposphere, especially in the 200-250 hPa layer, reaching peak coverage following deep convection. Cloud ice water content anomaly confined to pressures greater than about 250 hPa and peaks near 450 hPa within a few hours of the DC event but remain enhanced following the DC event. Consistent with the large increase in upper tropospheric cloud ice, albedo increases dramatically and persists for sometime following the DC event. Applying the method to the model demonstrates that it is able to capture the large-scale responses to DC events, most notably for outgoing longwave radiation, but there are a number of important differences. For example, the DC signature of upper tropospheric humidity consistently covers a broader horizontal area than what is observed. In addition, the DC events move eastward in the model, but westward in the observations, and exhibit an unrealistic 24 h repeat cycle. Moreover, the modeled upper tropospheric cloud fraction anomalies - despite being of comparable magnitude and exhibiting similar longevity - are confined to a thinner layer that is closer to the tropopause and peak earlier than in observations. Finally, the modeled ice water content anomalies at pressures greater than about 350 hPa are about twice as large as in the observations and do not persist as long after peak convection.

  17. Diagnosing the average spatio-temporal impact of convective systems - Part 1: A methodology for evaluating climate models

    NASA Astrophysics Data System (ADS)

    Johnston, M. S.; Eliasson, S.; Eriksson, P.; Forbes, R. M.; Wyser, K.; Zelinka, M. D.

    2013-12-01

    An earlier method to determine the mean response of upper-tropospheric water to localised deep convective systems (DC systems) is improved and applied to the EC-Earth climate model. Following Zelinka and Hartmann (2009), several fields related to moist processes and radiation from various satellites are composited with respect to the local maxima in rain rate to determine their spatio-temporal evolution with deep convection in the central Pacific Ocean. Major improvements to the earlier study are the isolation of DC systems in time so as to prevent multiple sampling of the same event, and a revised definition of the mean background state that allows for better characterisation of the DC-system-induced anomalies. The observed DC systems in this study propagate westward at ~4 m s-1. Both the upper-tropospheric relative humidity and the outgoing longwave radiation are substantially perturbed over a broad horizontal extent and for periods >30 h. The cloud fraction anomaly is fairly constant with height but small maximum can be seen around 200 hPa. The cloud ice water content anomaly is mostly confined to pressures greater than 150 hPa and reaches its maximum around 450 hPa, a few hours after the peak convection. Consistent with the large increase in upper-tropospheric cloud ice water content, albedo increases dramatically and persists about 30 h after peak convection. Applying the compositing technique to EC-Earth allows an assessment of the model representation of DC systems. The model captures the large-scale responses, most notably for outgoing longwave radiation, but there are a number of important differences. DC systems appear to propagate eastward in the model, suggesting a strong link to Kelvin waves instead of equatorial Rossby waves. The diurnal cycle in the model is more pronounced and appears to trigger new convection further to the west each time. Finally, the modelled ice water content anomaly peaks at pressures greater than 500 hPa and in the upper troposphere between 250 hPa and 500 hPa, there is less ice than the observations and it does not persist as long after peak convection. The modelled upper-tropospheric cloud fraction anomaly, however, is of a comparable magnitude and exhibits a similar longevity as the observations.

  18. The Moonwatch Programme, Part 8

    NASA Astrophysics Data System (ADS)

    Roberts, Greg

    2015-08-01

    This part deals with the satellite tracking done in Cape Town and covers the Kinetheodolite setup at the then Royal Observatory and manned by part time amateur observers. It also covers the activities of Roberts at his Kenilworth tracking site. The activities of Bill Hirst and his station at Bergvliet are also described.

  19. Staircase and Fractional Part Functions

    ERIC Educational Resources Information Center

    Amram, Meirav; Dagan, Miriam; Ioshpe, Michael; Satianov, Pavel

    2016-01-01

    The staircase and fractional part functions are basic examples of real functions. They can be applied in several parts of mathematics, such as analysis, number theory, formulas for primes, and so on; in computer programming, the floor and ceiling functions are provided by a significant number of programming languages--they have some basic uses in…

  20. Detecting Earthquakes--Part 2.

    ERIC Educational Resources Information Center

    Isenberg, C.; And Others

    1983-01-01

    Basic concepts associated with seismic wave propagation through the earth and the location of seismic events were explained in part 1 (appeared in January 1983 issue). This part focuses on the construction of a student seismometer for detecting earthquakes and underground nuclear explosions anywhere on the earth's surface. (Author/JN)

  1. 6. SITE OVERVIEW. PART 1 OF 6 PART PANORAMA WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. SITE OVERVIEW. PART 1 OF 6 PART PANORAMA WITH NOS. CA-265-7 TO CA-265-11. ARROYO SECO PARKWAY AS SEEN FROM RADIO TOWER HILL (APPROXIMATELY 34° 5' BY 118° 12'30" ON USGS LOS ANGELES QUADRANGLE). PART 1 SHOWS GRAND VIEW POINT AT RIGHT REAR (LOCATION OF CAMERA POSITION FOR PHOTOGRAPHS NOS. 265-1 TO CA-265-5) AND FIGUEROA VIADUCT OVERCROSSING; DOWNTOWN LOS ANGELES IS AT LEFT REAR. LOOKING 234° SW. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  2. The Majorana Parts Tracking Database

    DOE PAGESBeta

    Abgrall, N.

    2015-01-16

    The Majorana Demonstrator is an ultra-low background physics experiment searching for the neutrinoless double beta decay of 76Ge. The Majorana Parts Tracking Database is used to record the history of components used in the construction of the Demonstrator. The tracking implementation takes a novel approach based on the schema-free database technology CouchDB. Transportation, storage, and processes undergone by parts such as machining or cleaning are linked to part records. Tracking parts provides a great logistics benefit and an important quality assurance reference during construction. In addition, the location history of parts provides an estimate of their exposure to cosmic radiation.more » In summary, a web application for data entry and a radiation exposure calculator have been developed as tools for achieving the extreme radio-purity required for this rare decay search.« less

  3. The Majorana Parts Tracking Database

    SciTech Connect

    Abgrall, N.

    2015-01-16

    The Majorana Demonstrator is an ultra-low background physics experiment searching for the neutrinoless double beta decay of 76Ge. The Majorana Parts Tracking Database is used to record the history of components used in the construction of the Demonstrator. The tracking implementation takes a novel approach based on the schema-free database technology CouchDB. Transportation, storage, and processes undergone by parts such as machining or cleaning are linked to part records. Tracking parts provides a great logistics benefit and an important quality assurance reference during construction. In addition, the location history of parts provides an estimate of their exposure to cosmic radiation. In summary, a web application for data entry and a radiation exposure calculator have been developed as tools for achieving the extreme radio-purity required for this rare decay search.

  4. The MAJORANA Parts Tracking Database

    NASA Astrophysics Data System (ADS)

    Abgrall, N.; Aguayo, E.; Avignone, F. T.; Barabash, A. S.; Bertrand, F. E.; Brudanin, V.; Busch, M.; Byram, D.; Caldwell, A. S.; Chan, Y.-D.; Christofferson, C. D.; Combs, D. C.; Cuesta, C.; Detwiler, J. A.; Doe, P. J.; Efremenko, Yu.; Egorov, V.; Ejiri, H.; Elliott, S. R.; Esterline, J.; Fast, J. E.; Finnerty, P.; Fraenkle, F. M.; Galindo-Uribarri, A.; Giovanetti, G. K.; Goett, J.; Green, M. P.; Gruszko, J.; Guiseppe, V. E.; Gusev, K.; Hallin, A. L.; Hazama, R.; Hegai, A.; Henning, R.; Hoppe, E. W.; Howard, S.; Howe, M. A.; Keeter, K. J.; Kidd, M. F.; Kochetov, O.; Konovalov, S. I.; Kouzes, R. T.; LaFerriere, B. D.; Leon, J. Diaz; Leviner, L. E.; Loach, J. C.; MacMullin, J.; Martin, R. D.; Meijer, S. J.; Mertens, S.; Miller, M. L.; Mizouni, L.; Nomachi, M.; Orrell, J. L.; O`Shaughnessy, C.; Overman, N. R.; Petersburg, R.; Phillips, D. G.; Poon, A. W. P.; Pushkin, K.; Radford, D. C.; Rager, J.; Rielage, K.; Robertson, R. G. H.; Romero-Romero, E.; Ronquest, M. C.; Shanks, B.; Shima, T.; Shirchenko, M.; Snavely, K. J.; Snyder, N.; Soin, A.; Suriano, A. M.; Tedeschi, D.; Thompson, J.; Timkin, V.; Tornow, W.; Trimble, J. E.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Young, A. R.; Yu, C.-H.; Yumatov, V.; Zhitnikov, I.

    2015-04-01

    The MAJORANA DEMONSTRATOR is an ultra-low background physics experiment searching for the neutrinoless double beta decay of 76Ge. The MAJORANA Parts Tracking Database is used to record the history of components used in the construction of the DEMONSTRATOR. The tracking implementation takes a novel approach based on the schema-free database technology CouchDB. Transportation, storage, and processes undergone by parts such as machining or cleaning are linked to part records. Tracking parts provide a great logistics benefit and an important quality assurance reference during construction. In addition, the location history of parts provides an estimate of their exposure to cosmic radiation. A web application for data entry and a radiation exposure calculator have been developed as tools for achieving the extreme radio-purity required for this rare decay search.

  5. The Majorana Parts Tracking Database

    SciTech Connect

    Abgrall, N.; Aguayo, E.; Avignone, F. T.; Barabash, A. S.; Bertrand, F. E.; Brudanin, V.; Busch, M.; Byram, D.; Caldwell, A. S.; Chan, Y-D.; Christofferson, C. D.; Combs, D. C.; Cuesta, C.; Detwiler, J. A.; Doe, P. J.; Efremenko, Yu.; Egorov, V.; Ejiri, H.; Elliott, S. R.; Esterline, J.; Fast, J. E.; Finnerty, P.; Fraenkle, F. M.; Galindo-Uribarri, A.; Giovanetti, G. K.; Goett, J.; Green, M. P.; Gruszko, J.; Guiseppe, V. E.; Gusev, K.; Hallin, A. L.; Hazama, R.; Hegai, A.; Henning, R.; Hoppe, E. W.; Howard, S.; Howe, M. A.; Keeter, K. J.; Kidd, M. F.; Kochetov, O.; Konovalov, S. I.; Kouzes, R. T.; LaFerriere, B. D.; Leon, J. Diaz; Leviner, L. E.; Loach, J. C.; MacMullin, J.; Martin, R. D.; Meijer, S. J.; Mertens, S.; Miller, M. L.; Mizouni, L.; Nomachi, M.; Orrell, J. L.; O׳Shaughnessy, C.; Overman, N. R.; Petersburg, R.; Phillips, D. G.; Poon, A. W. P.; Pushkin, K.; Radford, D. C.; Rager, J.; Rielage, K.; Robertson, R. G. H.; Romero-Romero, E.; Ronquest, M. C.; Shanks, B.; Shima, T.; Shirchenko, M.; Snavely, K. J.; Snyder, N.; Soin, A.; Suriano, A. M.; Tedeschi, D.; Thompson, J.; Timkin, V.; Tornow, W.; Trimble, J. E.; Varner, R. L.; Vasilyev, S.; Vetter, K.; Vorren, K.; White, B. R.; Wilkerson, J. F.; Wiseman, C.; Xu, W.; Yakushev, E.; Young, A. R.; Yu, C. -H.; Yumatov, V.; Zhitnikov, I.

    2015-04-01

    The MAJORANA DEMONSTRATOR is an ultra-low background physics experiment searching for the neutrinoless double beta decay of 76Ge. The MAJORANA Parts Tracking Database is used to record the history of components used in the construction of the DEMONSTRATOR. Transportation, storage, and processes undergone by parts such as machining or cleaning are linked to part records. Tracking parts provides a great logistics benefit and an important quality assurance reference during construction. In addition, the location history of parts provides an estimate of their exposure to cosmic radiation. A web application for data entry and a radiation exposure calculator have been developed as tools for achieving the extreme radiopurity required for this rare decay search.

  6. GSFC preferred parts lists PPL-17

    NASA Technical Reports Server (NTRS)

    Baldini, B. P. (Editor)

    1984-01-01

    A listing of preferred parts, part upgrading procedures, part derating guidelines, and part screening procedures to be used in the selection, procurement, and application of parts for Goddard Space Flight Center (GSFC) space systems and ground support equipment is contained.

  7. Affine Kac-Moody symmetric spaces related with A{sub 1}{sup (1)}, A{sub 2}{sup (1)}, A{sub 2}{sup (2)}

    SciTech Connect

    Nayak, Saudamini Pati, K. C.

    2014-08-15

    Symmetric spaces associated with Lie algebras and Lie groups which are Riemannian manifolds have recently got a lot of attention in various branches of Physics for their role in classical/quantum integrable systems, transport phenomena, etc. Their infinite dimensional counter parts have recently been discovered which are affine Kac-Moody symmetric spaces. In this paper we have (algebraically) explicitly computed the affine Kac-Moody symmetric spaces associated with affine Kac-Moody algebras A{sub 1}{sup (1)},A{sub 2}{sup (1)},A{sub 2}{sup (2)}. We hope these types of spaces will play similar roles as that of symmetric spaces in many physical systems.

  8. Scutellarin inhibits cytochrome P450 isoenzyme 1A2 (CYP1A2) in rats.

    PubMed

    Jian, Tun-Yu; He, Jian-Chang; He, Gong-Hao; Feng, En-Fu; Li, Hong-Liang; Bai, Min; Xu, Gui-Li

    2012-08-01

    Scutellarin is the most important flavone glycoside in the herbal drug Erigeron breviscapus (Vant.) Hand.-Mazz. It is used frequently in the clinic to treat ischemic vascular diseases in China. However, the direct relationship between scutellarin and cytochrome P450 (CYP450) is unclear. The present study investigated the in vitro and in vivo effects of scutellarin on cytochrome P450 1A2 (CYP 1A2) metabolism. According to in vitro experiments, scutellarin (10-250 µM) decreased the formation of 4-acetamidophenol in a concentration-dependent manner, with an IC₅₀ value of 108.20 ± 0.657 µM. Furthermore, scutellarin exhibited a weak mixed-type inhibition against the activity of CYP1A2 in rat liver microsomes, with a K(i) value of 95.2 µM. Whereas in whole animal studies, scutellarin treatment for 7 days (at 5, 15, 30 mg/kg, i.p.) decreased the clearance (CL), and increased the T(1/2) (at 15, 30 mg/kg, i.p.), it did not affect the V(d) of phenacetin. Scutellarin treatment (at 5, 15, 30 mg/kg, i.p.) increased the AUC(0-∞) by 14.3%, 67.3% and 159.2%, respectively. Scutellarin at 30 mg/kg also weakly inhibited CYP1A2 activity, in accordance with our in vitro study. Thus, the results indicate that CYP1A2 is inhibited directly, but weakly, by scutellarin in vivo, and provide useful information on the safe and effective use of scutellarin in clinical practice. PMID:22228482

  9. Secretoglobin 1A1 and 1A1A Differentially Regulate Neutrophil Reactive Oxygen Species Production, Phagocytosis and Extracellular Trap Formation

    PubMed Central

    Côté, Olivier; Clark, Mary Ellen; Viel, Laurent; Labbé, Geneviève; Seah, Stephen Y. K.; Khan, Meraj A.; Douda, David N.; Palaniyar, Nades; Bienzle, Dorothee

    2014-01-01

    Secretoglobin family 1A member 1 (SCGB 1A1) is a small protein mainly secreted by mucosal epithelial cells of the lungs and uterus. SCGB 1A1, also known as club (Clara) cell secretory protein, represents a major constituent of airway surface fluid. The protein has anti-inflammatory properties, and its concentration is reduced in equine recurrent airway obstruction (RAO) and human asthma. RAO is characterized by reversible airway obstruction, bronchoconstriction and neutrophilic inflammation. Direct effects of SCGB 1A1 on neutrophil functions are unknown. We have recently identified that the SCGB1A1 gene is triplicated in equids and gives rise to two distinct proteins. In this study we produced the endogenously expressed forms of SCGBs (SCGB 1A1 and 1A1A) as recombinant proteins, and analyzed their effects on reactive oxygen species production, phagocytosis, chemotaxis and neutrophil extracellular trap (NET) formation ex vivo. We further evaluated whether NETs are present in vivo in control and inflamed lungs. Our data show that SCGB 1A1A but not SCGB 1A1 increase neutrophil oxidative burst and phagocytosis; and that both proteins markedly reduce neutrophil chemotaxis. SCGB 1A1A reduced chemotaxis significantly more than SCGB 1A1. NET formation was significantly reduced in a time- and concentration-dependent manner by SCGB 1A1 and 1A1A. SCGB mRNA in bronchial biopsies, and protein concentration in bronchoalveolar lavage fluid, was lower in horses with RAO. NETs were present in bronchoalveolar lavage fluid from horses with exacerbated RAO, but not in fluid from horses with RAO in remission or in challenged healthy horses. These findings indicate that SCGB 1A1 and 1A1A have overlapping and diverging functions. Considering disparities in the relative abundance of SCGB 1A1 and 1A1A in airway secretions of animals with RAO suggests that these functional differences may contribute to the pathogenesis of RAO and other neutrophilic inflammatory lung diseases. PMID:24777050

  10. Understanding the Multifaceted Role of Human Down Syndrome Kinase DYRK1A.

    PubMed

    Kay, L J; Smulders-Srinivasan, T K; Soundararajan, M

    2016-01-01

    The dual-specificity tyrosine (Y) phosphorylation-regulated kinase DYRK1A, also known as Down syndrome (DS) kinase, is a dosage-dependent signaling kinase that was originally shown to be highly expressed in DS patients as a consequence of trisomy 21. Although this was evident some time ago, it is only in recent investigations that the molecular roles of DYRK1A in a wide range of cellular processes are becoming increasingly apparent. Since initial knowledge on DYRK1A became evident through minibrain mnb, the Drosophila homolog of DYRK1A, this review will first summarize the scientific reports on minibrain and further expand on the well-established neuronal functions of mammalian and human DYRK1A. Recent investigations across the current decade have provided rather interesting and compelling evidence in establishing nonneuronal functions for DYRK1A, including its role in infection, immunity, cardiomyocyte biology, cancer, and cell cycle control. The latter part of this review will therefore focus in detail on the emerging nonneuronal functions of DYRK1A and summarize the regulatory role of DYRK1A in controlling Tau and α-synuclein. Finally, the emerging role of DYRK1A in Parkinson's disease will be outlined. PMID:27567487

  11. Cytochrome P450 1A1 Regulates Breast Cancer Cell Proliferation and Survival

    PubMed Central

    Rodriguez, Mariangellys; Potter, David A.

    2013-01-01

    Cytochrome P450 1A1 (CYP1A1) is an extrahepatic phase I metabolizing enzyme whose expression is suppressed under physiologic conditions, but can be induced by substrates via the aryl hydrocarbon receptor (AhR). Nonetheless, recent studies show that the majority of breast tumors constitutively express CYP1A1. These findings led us to test the hypothesis that CYP1A1 promotes breast cancer progression by evaluating the effects of CYP1A1 knock down on the proliferation and survival of the MCF7 and MDA-MB-231 lines. Independently of estrogen receptor status, CYP1A1 knock down decreases cell proliferation, decreases colony formation, blocks the cell cycle at G0/G1 associated with reduction of cyclin D1, and increases apoptosis associated with reduction of survivin. CYP1A1 knock down markedly increases phosphorylation of AMP-activated protein kinase (AMPK) and decreases phosphorylation of AKT, extracellular signal-regulated kinases 1 and 2 (ERK1/2), and 70kDa ribosomal protein S6 kinase (P70S6K). AMPK inhibition by compound C partially abrogates the pro-apoptotic effects of CYP1A1siRNA, suggesting that CYP1A1siRNA effects are mediated, in part, through AMPK signaling. Consistent with CYP1A1 knock down results, pharmacologic reduction of CYP1A1 levels by the phytopolyphenol carnosol also correlates with impaired proliferation and induced AMPK phosphorylation. These results indicate that reduction of basal CYP1A1 expression is critical for inhibition of proliferation, which is not affected by alpha-naphthoflavone-mediated inhibition of CYP1A1 activity nor modulated by AhR silencing. This study supports that CYP1A1 may promote breast cancer proliferation and survival, at least in part, through AMPK signaling and that reduction of CYP1A1 levels is a potential strategy for breast cancer therapeutics. PMID:23576571

  12. Aldehyde dehydrogenase 1A1 circumscribes high invasive glioma cells and predicts poor prognosis.

    PubMed

    Xu, Sen-Lin; Liu, Sha; Cui, Wei; Shi, Yu; Liu, Qin; Duan, Jiang-Jie; Yu, Shi-Cang; Zhang, Xia; Cui, You-Hong; Kung, Hsiang-Fu; Bian, Xiu-Wu

    2015-01-01

    Glioma is the most aggressive brain tumor with high invasiveness and poor prognosis. More reliable, sensitive and practical biomarkers to reveal glioma high invasiveness remain to be explored for the guidance of therapy. We herein evaluated the diagnostic and prognostic value of aldehyde dehydrogenase 1A1 (ALDH1A1) in the glioma specimens from 237 patients, and found that ADLH1A1 was frequently overexpressed in the high-grade glioma (WHO grade III-IV) as compared to the low-grade glioma (WHO grade I-II) patients. The tumor cells with ALDH1A1 expression were more abundant in the region between tumor and the borderline of adjacent tissue as compared to the central part of the tumor. ALDH1A1 overexpression was associated with poor differentiation and dismal prognosis. Notably, the overall and disease-free survivals of the patients who had ALDH1A1(+) tumor cells sparsely located in the adjacent tissue were much worse. Furthermore, ALDH1A1 expression was correlated with the "classical-like" (CL) subtype as we examined GBM specimens from 72 patients. Multivariate Cox regression analysis revealed that ALDH1A1 was an independent marker for glioma patients' outcome. Mechanistically, both in vitro and in vivo studies revealed that ALDH1A1(+) cells isolated from either a glioblastoma cell line U251 or primary glioblastoma cells displayed significant invasiveness, clonogenicity, and proliferation as compared to ALDH1A1(-) cells, due to increased levels of mRNA and protein for matrix metalloproteinase 2, 7 and 9 (MMP2, MMP7 and MMP9). These results indicate that ALDH1A1(+) cells contribute to the progression of glioma including invasion, proliferation and poor prognosis, and suggest that targeting ALDH1A1 may have important implications for the treatment of highly invasive glioma. PMID:26101711

  13. Polymorphisms of UGT1A1*6, UGT1A1*27 & UGT1A1*28 in three major ethnic groups from Malaysia

    PubMed Central

    Teh, L. K.; Hashim, H.; Zakaria, Z. A.; Salleh, M. Z.

    2012-01-01

    Background & objectives: Genetic polymorphisms of uridine diphosphate glucuronyltransferase 1A1 (UGT1A1) have been associated with a wide variation of responses among patients prescribed with irinotecan. Lack of this enzyme is known to be associated with a high incidence of severe toxicity. The objective of this study was to investigate the prevalence of three different variants of UGT1A1 (UGT1A1*6, UGT1A1*27 and UGT1A1*28), which are associated with reduced enzyme activity and increased irinotecan toxicity, in the three main ethnic groups in Malaysia (Malays, Chinese and Indians). Methods: A total of 306 healthy unrelated volunteers were screened for UGT1A1*28, UGT1A1*6 and UGT1A1*27. Blood samples (5 ml) were obtained from each subject and DNA was extracted. PCR based methods were designed and validated for detection of UGT1A1*6, UGT1A1*27 and UGT1A1*28. Direct DNA sequencing was performed to validate the results of randomly selected samples. Results: Malays and Indian have two-fold higher frequency of homozygous of UGT1A1*28 (7TA/7TA) which was 8 and 8.8 per cent, respectively compared to the Chinese (4.9%). However, the distribution of UGT1A1*6 and UGT1A1*27 showed no significant differences among them. UGT1A1*27 which has not been detected in Caucasian and African American population, was found in the Malaysian Malays (3.33%) and Malaysian Chinese (2.0%). Interpretation & conclusions: There was interethnic variability in the frequency of UGT1A1*28 in the Malaysian population. Our results suggest that genotyping of UGT1A1*6, UGT1A1*28 and UGT1A1*27 need to be performed before patients are prescribed with irinotecan due to their high prevalence of allelic variant which could lead to adverse drug reaction. PMID:22960892

  14. Indentured Parts List Maintenance and Part Assembly Capture Tool - IMPACT

    NASA Technical Reports Server (NTRS)

    Jain, Bobby; Morris, Jill; Sharpe, Kelly

    2004-01-01

    Johnson Space Center's (JSC's) indentured parts list (IPL) maintenance and parts assembly capture tool (IMPACT) is an easy-to-use graphical interface for viewing and maintaining the complex assembly hierarchies of large databases. IMPACT, already in use at JSC to support the International Space Station (ISS), queries, updates, modifies, and views data in IPL and associated resource data, functions that it can also perform, with modification, for any large commercial database. By enabling its users to efficiently view and manipulate IPL hierarchical data, IMPACT performs a function unlike that of any other tool. Through IMPACT, users will achieve results quickly, efficiently, and cost effectively.

  15. 45 CFR 630.105 - Does this part apply to me?

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Does this part apply to me? 630.105 Section 630.105 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... this part apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of...

  16. 45 CFR 630.105 - Does this part apply to me?

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Does this part apply to me? 630.105 Section 630.105 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... this part apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of...

  17. 49 CFR Appendix A to Part 240 - Schedule of Civil Penalties 1

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... $100,000 for any violation where circumstances warrant. See 49 CFR part 209, appendix A. ... 49 Transportation 4 2010-10-01 2010-10-01 false Schedule of Civil Penalties 1 A Appendix A to Part.... A Appendix A to Part 240—Schedule of Civil Penalties 1 Section Violation Willful violation Subpart...

  18. 49 CFR Appendix A to Part 224 - Schedule of Civil Penalties1

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... where circumstances warrant. See 49 CFR part 209, appendix A. ... 49 Transportation 4 2012-10-01 2012-10-01 false Schedule of Civil Penalties1 A Appendix A to Part... Appendix A to Part 224—Schedule of Civil Penalties1 Subpart B—Application, Inspection, and Maintenance...

  19. 49 CFR Appendix A to Part 224 - Schedule of Civil Penalties1

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... where circumstances warrant. See 49 CFR part 209, appendix A. ... 49 Transportation 4 2011-10-01 2011-10-01 false Schedule of Civil Penalties1 A Appendix A to Part... Appendix A to Part 224—Schedule of Civil Penalties1 Subpart B—Application, Inspection, and Maintenance...

  20. Dimerization of human uridine diphosphate glucuronosyltransferase allozymes 1A1 and 1A9 alters their quercetin glucuronidation activities.

    PubMed

    Liu, Yan-Qing; Yuan, Ling-Min; Gao, Zhang-Zhao; Xiao, Yong-Sheng; Sun, Hong-Ying; Yu, Lu-Shan; Zeng, Su

    2016-01-01

    Uridine diphosphate glucuronosyltransferase 1A (UGT1A) is a major phase II drug-metabolism enzyme superfamily involved in the glucuronidation of endobiotics and xenobiotics in humans. Many polymorphisms in UGT1A genes are reported to inhibit or decrease UGT1A activity. In this study, two UGT1A1 allozymes, UGT1A1 wild-type and a splice mutant, as well as UGT1A9 wild-type and its three UGT1A9 allozymes, UGT1A9*2(C3Y), UGT1A9*3(M33T), and UGT1A9*5(D256N) were single- or double-expressed in a Bac-to-Bac expression system. Dimerization of UGT1A1 or UGT1A9 allozymes was observed via fluorescence resonance energy transfer (FRET) and co-immunoprecipitation analysis. SNPs of UGT1A altered the ability of protein-protein interaction, resulting in differential FRET efficiencies and donor-acceptor r distances. Dimerization changed the chemical regioselectivity, substrate-binding affinity, and enzymatic activity of UGT1A1 and UGT1A9 in glucuronidation of quercetin. These findings provide molecular insights into the consequences of homozygous and heterozygous UGT1A1 and UGT1A9 allozymes expression on quercetin glucuronidation. PMID:27025983

  1. Dimerization of human uridine diphosphate glucuronosyltransferase allozymes 1A1 and 1A9 alters their quercetin glucuronidation activities

    PubMed Central

    Liu, Yan-Qing; Yuan, Ling-Min; Gao, Zhang-Zhao; Xiao, Yong-Sheng; Sun, Hong-Ying; Yu, Lu-Shan; Zeng, Su

    2016-01-01

    Uridine diphosphate glucuronosyltransferase 1A (UGT1A) is a major phase II drug-metabolism enzyme superfamily involved in the glucuronidation of endobiotics and xenobiotics in humans. Many polymorphisms in UGT1A genes are reported to inhibit or decrease UGT1A activity. In this study, two UGT1A1 allozymes, UGT1A1 wild-type and a splice mutant, as well as UGT1A9 wild-type and its three UGT1A9 allozymes, UGT1A9*2(C3Y), UGT1A9*3(M33T), and UGT1A9*5(D256N) were single- or double-expressed in a Bac-to-Bac expression system. Dimerization of UGT1A1 or UGT1A9 allozymes was observed via fluorescence resonance energy transfer (FRET) and co-immunoprecipitation analysis. SNPs of UGT1A altered the ability of protein-protein interaction, resulting in differential FRET efficiencies and donor-acceptor r distances. Dimerization changed the chemical regioselectivity, substrate-binding affinity, and enzymatic activity of UGT1A1 and UGT1A9 in glucuronidation of quercetin. These findings provide molecular insights into the consequences of homozygous and heterozygous UGT1A1 and UGT1A9 allozymes expression on quercetin glucuronidation. PMID:27025983

  2. Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities.

    PubMed

    Mohamed, Mohamed-Eslam F; Frye, Reginald F

    2011-09-01

    The aim of this study was to investigate the effect of commonly used botanicals on UDP-glucuronosyltransferase (UGT) 1A4, UGT1A6, and UGT1A9 activities in human liver microsomes. The extracts screened were black cohosh, cranberry, echinacea, garlic, ginkgo, ginseng, milk thistle, saw palmetto, and valerian in addition to the green tea catechin epigallocatechin gallate (EGCG). Formation of trifluoperazine glucuronide, serotonin glucuronide, and mycophenolic acid phenolic glucuronide was used as an index reaction for UGT1A4, UGT1A6, and UGT1A9 activities, respectively, in human liver microsomes. Inhibition potency was expressed as the concentration of the inhibitor at 50% activity (IC(50)) and the volume in which the dose could be diluted to generate an IC(50)-equivalent concentration [volume/dose index (VDI)]. Potential inhibitors were EGCG for UGT1A4, milk thistle for both UGT1A6 and UGT1A9, saw palmetto for UGT1A6, and cranberry for UGT1A9. EGCG inhibited UGT1A4 with an IC(50) value of (mean ± S.E.) 33.8 ± 3.1 μg/ml. Milk thistle inhibited both UGT1A6 and UGT1A9 with IC(50) values of 59.5 ± 3.6 and 33.6 ± 3.1 μg/ml, respectively. Saw palmetto and cranberry weakly inhibited UGT1A6 and UGT1A9, respectively, with IC(50) values >100 μg/ml. For each inhibition, VDI was calculated to determine the potential of achieving IC(50)-equivalent concentrations in vivo. VDI values for inhibitors indicate a potential for inhibition of first-pass glucuronidation of UGT1A4, UGT1A6, and UGT1A9 substrates. These results highlight the possibility of herb-drug interactions through modulation of UGT enzyme activities. Further clinical studies are warranted to investigate the in vivo extent of the observed interactions. PMID:21632963

  3. Formation of parting in quartz

    NASA Astrophysics Data System (ADS)

    Jørgen Kjøll, Hans; Eske Sørensen, Bjørn

    2014-05-01

    This paper presents hydrothermal quartz with macroscopic planar parting from the Mesoproterozoic Modum complex in southern Norway. Similar macroscopic parting in hydrothermal quartz with macroscopic planar structures has only been described from two localities in the world; Madagascar (Flörke et al., 1981) and Southern California (Murdoch et al., 1938). The study area consists of well foliated and banded sillimanite- garnet- amphibolite- mica gneiss that is cut at high angle by hydrothermal veins containing albite, chlinoclore, hornblende, hydroxyl apatite and quartz. The rim of the veins is generally made up of almost pure end-member euhedral albite. Then there is vugs with euhedral hornblende (10-25cm long) and euhedral hydroxyl apatite with size ranging from mm scale to several cm. Some places the quartz encloses apatite and hornblende. The quartz is anhedral, inequigranular with undulose extinction bordering sub grain rotation. It has large planar penetrative parting faces with pearly luster; however this is not consistent throughout the outcrop and some places the penetrative faces disappears and the quartz has a conchoidal fracture. The planar faces continue throughout the specimens with a few mm spacing. Thin sections oriented perpendicular to the most pronounced planar structure show lamellas that extinguishes at small angles (2 degrees) to each other. EBSD mapping of the planar faces shows two orientations {0-111} and {1-101}, corresponding to the r- and z-faces respectively, separated by irregular boundaries. The misorientation between these two crystallographic orientations on the parting is a 60 degree rotation on [0 0 1] in correspondence to the dauphiné twin law. Investigations conducted on thin sections cut orthogonal to the parting shows that the parting cuts and offsets the dauphiné twins, indicating a late genesis of the parting. However some internal stress induced movement of the twins are visible. SEM-CL documents three generations of quartz

  4. Cell Cycle Restriction Is More Important Than Apoptosis Induction for RASSF1A Protein Tumor Suppression*

    PubMed Central

    Donninger, Howard; Clark, Jennifer A.; Monaghan, Megan K.; Schmidt, M. Lee; Vos, Michele; Clark, Geoffrey J.

    2014-01-01

    The Ras association domain family protein 1A (RASSF1A) is arguably one of the most frequently inactivated tumor suppressors in human cancer. RASSF1A modulates apoptosis via the Hippo and Bax pathways but also modulates the cell cycle. In part, cell cycle regulation appears to be dependent upon the ability of RASSF1A to complex with microtubules and regulate their dynamics. Which property of RASSF1A, apoptosis induction or microtubule regulation, is responsible for its tumor suppressor function is not known. We have identified a short conserved motif that is essential for the binding of RASSF family proteins with microtubule-associated proteins. By making a single point mutation in the motif, we were able to generate a RASSF1A variant that retains wild-type apoptotic properties but completely loses the ability to bind microtubule-associated proteins and complex with microtubules. Comparison of this mutant to wild-type RASSF1A showed that, despite retaining its proapoptotic properties, the mutant was completely unable to induce cell cycle arrest or suppress the tumorigenic phenotype. Therefore, it appears that the cell cycle/microtubule effects of RASSF1A are key to its tumor suppressor function rather than its apoptotic effects. PMID:25225292

  5. Calculus: A Computer Oriented Presentation, Part 1 [and] Part 2.

    ERIC Educational Resources Information Center

    Stenberg, Warren; Walker, Robert J.

    Parts one and two of a one-year computer-oriented calculus course (without analytic geometry) are presented. The ideas of calculus are introduced and motivated through computer (i.e., algorithmic) concepts. An introduction to computing via algorithms and a simple flow chart language allows the book to be self-contained, except that material on…

  6. Border Issues in Education, Part 1 [and] Part 2.

    ERIC Educational Resources Information Center

    Alexander-Kasparik, Rosalind, Ed.; Soulas, John, Comp.

    1994-01-01

    These newsletters examine issues in education along the United States and Mexico border. Topics in Part 1 include the ramifications of the North American Free Trade Agreement (NAFTA) for education, the impact of immigration on schools, and the structure and history of the Mexican educational system and its reforms in theory and practice. Educators…

  7. X-pinch. Part II

    NASA Astrophysics Data System (ADS)

    Pikuz, S. A.; Shelkovenko, T. A.; Hammer, D. A.

    2015-06-01

    Results of experimental studies of the X-pinch since its invention and implementation in 1982 at the Lebedev Physical Institute are presented. The review consists of two parts. The first part briefly outlines the history of creation and studies of X-pinches, describes the diagnostic techniques and devices developed during these studies, and presents the main results obtained in studying the physical processes occurring in the X-pinch. The second part is devoted to the results of detailed studies of the spatial, temporal, and spectral characteristics of the X-pinch hot spot—the region where the highest plasma parameters are achieved and which is a source of X-ray emission with extreme parameters. Some results of X-pinch simulations are also presented.

  8. X-pinch. Part II

    SciTech Connect

    Pikuz, S. A. Shelkovenko, T. A.; Hammer, D. A.

    2015-06-15

    Results of experimental studies of the X-pinch since its invention and implementation in 1982 at the Lebedev Physical Institute are presented. The review consists of two parts. The first part briefly outlines the history of creation and studies of X-pinches, describes the diagnostic techniques and devices developed during these studies, and presents the main results obtained in studying the physical processes occurring in the X-pinch. The second part is devoted to the results of detailed studies of the spatial, temporal, and spectral characteristics of the X-pinch hot spot—the region where the highest plasma parameters are achieved and which is a source of X-ray emission with extreme parameters. Some results of X-pinch simulations are also presented.

  9. Part Fixturing For Diamond Machining

    NASA Astrophysics Data System (ADS)

    Chaloux, Leonard E.

    1984-12-01

    Successful production of diamond turned components can be extremely dependent on the fixturing used to support the workpiece during the machining operation. Typical fixturing methods include vacuum chucking, air chucking and mechanical clamping. Depending on the type of part to be machined, suggested fixturing methods can vary widely. For example, a part requiring a flycut surface is not subject to the centrifugal forces and balance requirements of a part that must be turned about an axis of rotation. Therefore, in many cases the fixturing required for flycutting may be much simpler than that required for turning. In all cases, there are general guidelines that should be followed to determine the best method of fixturing.

  10. MISR Level 1A CCD Science data, all cameras (MIL1A_V2)

    NASA Technical Reports Server (NTRS)

    Diner, David J. (Principal Investigator)

    The Level 1A data are raw MISR data that are decommutated, reformatted 12-bit Level 0 data shifted to byte boundaries, i.e., reversal of square-root encoding applied and converted to 16 bit, and annotated (e.g., with time information). These data are used by the Level 1B1 processing algorithm to generate calibrated radiances. The science data output preserves the spatial sampling rate of the Level 0 raw MISR CCD science data. CCD data are collected during routine science observations of the sunlit portion of the Earth. Each product represents one 'granule' of data. A 'granule' is defined to be the smallest unit of data required for MISR processing. Also, included in the Level 1A product are pointers to calibration coefficient files provided for Level 1B processing. [Location=GLOBAL] [Temporal_Coverage: Start_Date=2000-02-24; Stop_Date=] [Spatial_Coverage: Southernmost_Latitude=-90; Northernmost_Latitude=90; Westernmost_Longitude=-180; Easternmost_Longitude=180].

  11. Slip-Cast Superconductive Parts

    NASA Technical Reports Server (NTRS)

    Wise, Stephanie A.; Buckley, John D.; Vasquez, Peter; Buck, Gregory M.; Hicks, Lana P.; Hooker, Matthew W.; Taylor, Theodore D.

    1993-01-01

    Complex shapes fabricated without machining. Nonaqueous slip-casting technique used to form complexly shaped parts from high-temperature superconductive materials like YBa(2)Cu(3)O(7-delta). Such parts useful in motors, vibration dampers, and bearings. In process, organic solvent used as liquid medium. Ceramic molds made by lost-wax process used instead of plaster-of-paris molds, used in aqueous slip-casting but impervious to organic solvents and cannot drain away liquid medium. Organic-solvent-based castings do not stick to ceramic molds as they do to plaster molds.

  12. Surface Seal for Carbon Parts

    NASA Technical Reports Server (NTRS)

    Shuford, D. M.; Spruiell, J. P.

    1982-01-01

    Surface pores in parts made of graphite or reinforced-carbon/ carbon materials are sealed by a silicon carbide-based coating. Coating inhibits subsurface oxidation and lengthens part life. Starting material for coating is graphite felt, which is converted to silicon carbide felt by processing it according to a prescribed time/temperature schedule. Converted felt is pulverized in a ball mill and resulting powder is mixed with an equal weight of black silicon carbide powder. Powder mixture is combined with an equal weight of adhesive to form a paste.

  13. Grinding Parts For Automatic Welding

    NASA Technical Reports Server (NTRS)

    Burley, Richard K.; Hoult, William S.

    1989-01-01

    Rollers guide grinding tool along prospective welding path. Skatelike fixture holds rotary grinder or file for machining large-diameter rings or ring segments in preparation for welding. Operator grasps handles to push rolling fixture along part. Rollers maintain precise dimensional relationship so grinding wheel cuts precise depth. Fixture-mounted grinder machines surface to quality sufficient for automatic welding; manual welding with attendant variations and distortion not necessary. Developed to enable automatic welding of parts, manual welding of which resulted in weld bead permeated with microscopic fissures.

  14. Understanding quantitative research: part 1.

    PubMed

    Hoe, Juanita; Hoare, Zoë

    This article, which is the first in a two-part series, provides an introduction to understanding quantitative research, basic statistics and terminology used in research articles. Critical appraisal of research articles is essential to ensure that nurses remain up to date with evidence-based practice to provide consistent and high-quality nursing care. This article focuses on developing critical appraisal skills and understanding the use and implications of different quantitative approaches to research. Part two of this article will focus on explaining common statistical terms and the presentation of statistical data in quantitative research. PMID:23346707

  15. Intermediate Phenotypes of ATP1A3 Mutations: Phenotype–Genotype Correlations

    PubMed Central

    Termsarasab, Pichet; Yang, Amy C.; Frucht, Steven J.

    2015-01-01

    Background ATP1A3-related disorders include rapid-onset dystonia–parkinsonism (RDP or DYT12), alternating hemiplegia of childhood (AHC), and CAPOS syndrome (Cerebellar ataxia, Areflexia, Pes cavus, Optic atrophy, and Sensorineural hearing loss). Case Report We report two cases with intermediate forms between RDP and AHC. Patient 1 initially presented with the AHC phenotype, but the RDP phenotype emerged at age 14 years. The second patient presented with levodopa-responsive paroxysmal oculogyria, a finding never before reported in ATP1A3-related disorders. Genetic testing confirmed heterozygous changes in the ATP1A3 gene in both patients, one of them novel. Discussion Intermediate phenotypes of RDP and AHC support the concept that these two disorders are part of a spectrum. We add our cases to the phenotype–genotype correlations of ATP1A3-related disorders. PMID:26417536

  16. Parts Specialist. Teacher Edition. Second Edition.

    ERIC Educational Resources Information Center

    Fuqua, Lou; And Others

    This set of instructional materials provides secondary and postsecondary students with an opportunity to explore the career choices available in the parts merchandising industry. The skills presented are useful to any student pursuing a career in auto parts, heavy equipment parts, small engine parts, tractor parts, appliance parts, or for any…

  17. List of Preferred Electronic Parts

    NASA Technical Reports Server (NTRS)

    Covey, R. E.; Scott, W. R.; Hess, L. M.; Steffy, G.; Stott, F. R.

    1986-01-01

    Components passed stringent qualification tests tabulated and described. Destructive and nondestructive qualification testing confirmed parts capable of withstanding spacecraft environments without excessive degradation and have stable characteristics during operating lives. Testing assessed effects of electrical, environmental, and mechanical stresses in various levels and time durations.

  18. Death: A Part of Life.

    ERIC Educational Resources Information Center

    Otero, George G.; Harris, Zoanne

    This two-part curriculum unit includes 20 slides depicting Days of the Dead in Mexico and the United States. The unit is designed to help middle school students compare customs and practices associated with death throughout the world in a way that promotes understanding of the values and needs that produce and are reinforced by death rituals and…

  19. Local Area Networks: Part II.

    ERIC Educational Resources Information Center

    Dessy, Raymond E., Ed.

    1982-01-01

    Discusses five approaches used by industry/colleges to provide local area network (LAN) capabilities in the analytical laboratory: (1) mixed baseband bus network coupled to a star net; (2) broadband bus network; (3) ring network; (4) star network coupled to broadband net; and (5) simple multiprocessor center. Part I (September issue) focused on…

  20. Hydroforming of flanged tubular part

    SciTech Connect

    Joo, B. D.; Jang, J. H.; Choi, M. K.; Moon, Y. H.

    2010-06-15

    Tube hydroforming is the technology that utilizes hydraulic pressure to form a tube into desired shapes inside die cavities. Recently, tube hydroforming technology draws attentions of automotive industries due to its advantages such as weight reduction, increased strength, improved quality and reduced tooling cost. Hydroformed automotive parts used as structural components in vehicle body frame or subframe often have to be structurally joined at some point. Therefore it is useful if the hydroformed automotive parts can be given a localized attachment flange. In this study, a tube hydroformed product which has flange has been formed at various processing conditions. To accomplish successful flange hydroforming process, thorough investigation on proper combination of process parameters such as internal hydraulic pressure and tool geometry has been performed. For the process design FE analysis was performed with Dynaform 5.5. With optimized die parting angle and circumferential expansion ratio, hydroforming experiments to form flange were performed and forming characteristics at various process conditions were analyzed. The results show that flanged parts can be successfully produced by tube hydroforming process.

  1. Piecing Together a College Education behind Bars. Part One [and] Part Two [and] Part Three [and] Part Four.

    ERIC Educational Resources Information Center

    Taylor, Jon Marc

    2002-01-01

    This is a four-part article on how to earn a college degree from inside prison. The author, who earned his master's while in prison, argues that education offers prisoners the best chance of staying out of prison after their release, as well as qualifying them for a decent job and easing social reintegration. The author outlines the approaches…

  2. Laserdisk Directory--Part 1.

    ERIC Educational Resources Information Center

    Connolly, Bruce, Comp.

    1986-01-01

    This first installment of four-part "Online/Database Laserdisk Directory" reports on aspects of laserdisks including: product name; product description; company name; conpatibility information; type of laserdisk (compact disc read-only-memory, videodisk); software used; interface with magnetic media capability; conditions of usage; price;…

  3. Air Pollution Control, Part I.

    ERIC Educational Resources Information Center

    Strauss, Werner, Ed.

    Authoritative reviews in seven areas of current importance in air pollution control are supplied in this volume, the first of a two-part set. Titles contained in this book are: "Dispersion of Pollutants Emitted into the Atmosphere,""The Formation and Control of Oxides of Nitrogen in Air Pollution,""The Control of Sulfur Emissions from Combustion…

  4. OCCUPATIONS FOR YOU, PART ONE.

    ERIC Educational Resources Information Center

    DES ROCHES, DEAN L.

    DEVELOPED AS PART OF A CURRICULUM PROJECT DESCRIBED IN VT 004 454 TO HELP YOUNG PEOPLE LEARN BASIC PRINCIPLES AND CONCEPTS OF MECHANICS AND TECHNOLOGY, THIS BOOK WAS DESIGNED TO STIMULATE INTEREST AND ANSWER QUESTIONS ABOUT VOCATIONAL CHOICE, STIMULATE INTEREST IN READING, AND PROVIDE CONTENT TO RELATE TO ACADEMIC STUDY. THE MATERIALS DEVELOPED IN…

  5. Roots/Routes: Part II

    ERIC Educational Resources Information Center

    Swanson, Dalene M.

    2009-01-01

    This narrative acts as an articulation of a journey of many routes. Following Part I of the same research journey of rootedness/routedness, it debates the nature of transformation and transcendence beyond personal and political paradoxes informed by neoliberalism and related repressive globalizing discourses. Through a more personal, descriptive,…

  6. Taking Part One GNVQ Forward.

    ERIC Educational Resources Information Center

    Frankland, Gillian; Ebrahim, Nazir

    This document is intended to assist practitioners involved in the delivery of Part One General National Vocational Qualifications (GNVQs), which are GNVQs designed for students in the United Kingdom who are at Key Stage 4 and the post-16 level. Section 1 examines the following topics of interest to centers that are contemplating introducing Part…

  7. Readings in Albanian. Part 1.

    ERIC Educational Resources Information Center

    Newmark, Leonard; And Others

    This text is designed to enable a student who knows English to gain reading proficiency in Albanian. Part One, which is presented here, includes the first 30 of the 100 units in the complete course. The units include texts from various periods of Albanian writing and include a variety of contents and styles: folklore, biography, news articles,…

  8. Part-Time Faculty Handbook.

    ERIC Educational Resources Information Center

    College of the Mainland, Texas City, TX.

    This document contains comprehensive information designed to orient the part-time faculty member to the College of the Mainland. Information included in the handbook covers the history and philosophy of the college; student and instructor rights; a description of social and economic characteristics of the students; a description of the faculty;…

  9. Glues Used in Airplane Parts

    NASA Technical Reports Server (NTRS)

    Allen, S W; Truax, T R

    1920-01-01

    This report was prepared for the National Advisory Committee for Aeronautics and presents the results of investigations conducted by the Forest Products Laboratory of the United States Forest Service on the manufacture, preparation, application, testing and physical properties of the different types of glues used in wood airplane parts.

  10. Playing It Safe: Part II.

    ERIC Educational Resources Information Center

    Penman, Kenneth A.; Niccolai, Frances R.

    1985-01-01

    Explains how to prevent outdoor sports injuries; discusses related litigation and specific cases involving playing field turf, tennis, skiing, and pools; and sets out facility design and maintenance considerations and recommendations. A sidebar provides information about injury insurance available to NCAA schools. Part I of this article appeared…

  11. Cleaning of parts for new manufacturing and parts rebuilding

    NASA Astrophysics Data System (ADS)

    Doherty, Jeff

    1994-06-01

    Parts cleaning is the largest single expense, and the most time consuming activity, in rebuilding and new manufacturing. On average, 25% to 40% of the total labor and overhead burden is spent on cleaning. EPA and OSHA pressures add to the burden by making some methods and chemicals obsolete. Some of the processes and chemicals in current use will be curtailed and or outlawed in the future. How can a shops and industries make long term decisions or capital investments in cleaning and process improvements when the government keeps changing its rules? At the MART Corporation in Saint Louis, Missouri, we manufacture a line of cabinet-style batch cleaning machines known as Power Washers. Twenty years ago MART invented and patented the Power Washer process, a cleaning method that recycles wash solution and blasts contaminates as they are washed off the more heavily contaminated parts. Since the initial invention MART has continued to R&D the washing process and develop ancillary systems that comply with EPA and OSHA regulations. For applications involving new industrial parts or items requiring specification cleaned surfaces. MART provides filtration and solution conditioning systems, part drying operations, and triple rinsing. Units are available in stainless steel or higher alloys. We are not alone in the washer manufacturing business. You have many choices of cleaning solutions (no pun intended) which will perform in your operations and yield good results. As a manufacturer, we are interested in your success with our equipment. We have all heard the horror stories of companies having selected inappropriate cleaning systems and or processes which then brought the company to its knees, production wise. Assembly, appearance, warranty, and performance shortcomings of finished products can often be directly related to the cleaning process and its shortcomings.

  12. Getting in Taped, Part I and Part II

    ERIC Educational Resources Information Center

    Cundy, H. M.; Higgins, J.

    1971-01-01

    This article is in two parts: discussion of mathematical concepts involved in converting the reading from the tape-recorder counter which counts the turns of the run-off spool to that from the counter which counts turns of the take-up spool; calculating the length of tape run off when given the reading from the tape-recorder counter of the run-off…

  13. Pharmacogenetics of the organic anion transporting polypeptide 1A2

    PubMed Central

    Franke, Ryan M; Scherkenbach, Lisa A; Sparreboom, Alex

    2016-01-01

    The solute carrier, human organic anion transporting polypeptide 1A2 (OATP1A2, OATP-A, OATP1 and OATP) is highly expressed in the intestine, kidney, cholangiocytes and the blood–brain barrier. This localization suggests that OATP1A2 may be vitally important in the absorption, distribution and excretion of a broad array of clinically important drugs. Several nonsynonymous polymorphisms have been identified in the gene encoding OATP1A2, SLCO1A2 (SLC21A3), with some of these variants demonstrating functional changes in the transport of OATP1A2 substrates. PMID:19290786

  14. Avermectin B sub 1a metabolism in celery: A residue study

    SciTech Connect

    Moye, H.A.; Malagodi, M.H.; Yoh, Jau; Deyrup, C.L.; Chang Shou Mei; Leibee, G.L. ); Ku, C.C.; Wislocki, P.G. )

    1990-01-01

    Radioactivity equivalent to less than 4% of the total avermectin B{sub 1a} applied to mature and immature celery as a mixture of unlabeled and ({sup 14}C)- or ({sup 3}H) avermectin B{sub 1a} remained in harvested plants. The half-lives of radiolabeled avermectin B{sub 1a} residues as measured by the dissipation of total {sup 3}H radioactivity from celery parts ranged from 5.2 to 12.9 days in celery treated at 0.01 and 0.10 lb of AI/acre. The percentage of total radioactivity in celery parts readily extractable with acetone (range of 57.8-97.1%) generally decreased with increasing postharvest intervals. High-performance liquid chromatography of acetone extracts of celery leaves and stalks produced four discernible peaks of radioactivity, designated as polar metabolites, moderately polar metabolites, avermectin B{sub 1a}, and the {Delta}{sup 8,9} isomer of avermectin B{sub 1a}. The percentage of acetone extract radioactivity represented by polar metabolites generally increased with increasing postharvest intervals.

  15. The Chromatin Remodeling Component Arid1a Is a Suppressor of Spontaneous Mammary Tumors in Mice.

    PubMed

    Kartha, Nithya; Shen, Lishuang; Maskin, Carolyn; Wallace, Marsha; Schimenti, John C

    2016-08-01

    Human cancer genome studies have identified the SWI/SNF chromatin remodeling complex member ARID1A as one of the most frequently altered genes in several tumor types. Its role as an ovarian tumor suppressor has been supported in compound knockout mice. Here, we provide genetic and functional evidence that Arid1a is a bona fide mammary tumor suppressor, using the Chromosome aberrations occurring spontaneously 3 (Chaos3) mouse model of sporadic breast cancer. About 70% of mammary tumors that formed in these mice contained a spontaneous deletion removing all or part of one Arid1a allele. Restoration of Arid1a expression in a Chaos3 mammary tumor line with low Arid1a levels greatly impaired its ability to form tumors following injection into cleared mammary glands, indicating that ARID1A insufficiency is crucial for maintenance of these Trp53-proficient tumors. Transcriptome analysis of tumor cells before and after reintroduction of Arid1a expression revealed alterations in growth signaling and cell-cycle checkpoint pathways, in particular the activation of the TRP53 pathway. Consistent with the latter, Arid1a reexpression in tumor cells led to increased p21 (Cdkn1a) expression and dramatic accumulation of cells in G2 phase of the cell cycle. These results not only provide in vivo evidence for a tumor suppressive and/or maintenance role in breast cancer, but also indicate a potential opportunity for therapeutic intervention in ARID1A-deficient human breast cancer subtypes that retain one intact copy of the gene and also maintain wild-type TRP53 activity. PMID:27280691

  16. 40 CFR Table 1a to Subpart Ec of... - Emissions Limits for Small, Medium, and Large HMIWI at Affected Facilities as Defined in § 60.50c...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Large HMIWI at Affected Facilities as Defined in § 60.50c(a)(1) and (2) 1A Table 1A to Subpart Ec of... Table 1A to Subpart Ec of Part 60—Emissions Limits for Small, Medium, and Large HMIWI at Affected... limits HMIWI size Small Medium Large Averaging time 1 Method for demonstrating compliance 2...

  17. Modernizing medical photography, part 1.

    PubMed

    Crompton, Paul

    2004-12-01

    Government, media and public focus on waiting times in the National Health Service in the United Kingdom has forced the organization to look closely at the process by which a patient progresses through an increasingly complex and ever changing system. In an effort to streamline the patient journey or care pathway, modernizers have turned to business and manufacturing for solutions. Whilst medical photographers need to recognize their role in this context, they are also facing major technological modernization through the development of digital photography. Part 1 of this paper looks at the origins of some of the techniques presently being used to modernize the patient journey. Part 2 shows how these tools of modernization can be utilized to harness the advantages of digital technology to provide a modern and appropriate medical photography service in a large, disparate teaching hospital. PMID:15805027

  18. The Inconvenient Truth. Part 2

    SciTech Connect

    Athanasiou, T.

    2007-01-15

    Essay-type of publication on what should happen next after Al Gore's presentations on the Inconvenient Truth about the impacts of climate change. The essay states in the first lines: 'We've seen the movie, so we know the first part - we're in trouble deep. And it's time, past time, for at least some of us to go beyond warning to planning, to start talking seriously about a global crash program to stabilize the climate.

  19. 26 CFR 1.148-1A - Definitions and elections.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Definitions and elections. 1.148-1A Section 1.148-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX....148-1A Definitions and elections. (a) . For guidance see § 1.148-1. (b) Certain...

  20. 26 CFR 1.148-1A - Definitions and elections.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Definitions and elections. 1.148-1A Section 1.148-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX....148-1A Definitions and elections. (a) . For guidance see § 1.148-1. (b) Certain...

  1. 26 CFR 1.148-1A - Definitions and elections.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Definitions and elections. 1.148-1A Section 1.148-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX....148-1A Definitions and elections. (a) . For guidance see § 1.148-1. (b) Certain...

  2. 26 CFR 1.148-1A - Definitions and elections.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Definitions and elections. 1.148-1A Section 1.148-1A Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX....148-1A Definitions and elections. (a) . For guidance see § 1.148-1. (b) Certain...

  3. 7 CFR 1a.5 - Responsibility of the Inspector General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Responsibility of the Inspector General. 1a.5 Section 1a.5 Agriculture Office of the Secretary of Agriculture LAW ENFORCEMENT AUTHORITIES § 1a.5 Responsibility of the Inspector General. The Inspector General shall: (a) Issue directives conforming to...

  4. Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.

    PubMed

    Ofori, Edward; Zhu, Xue Y; Etukala, Jagan R; Peprah, Kwakye; Jordan, Kamanski R; Adkins, Adia A; Bricker, Barbara A; Kang, Hye J; Huang, Xi-Ping; Roth, Bryan L; Ablordeppey, Seth Y

    2016-08-15

    5-HT1A and 5-HT7 receptors have been at the center of discussions recently due in part to their major role in the etiology of major central nervous system diseases such as depression, sleep disorders, and schizophrenia. As part of our search to identify dual targeting ligands for these receptors, we have carried out a systematic modification of a selective 5HT7 receptor ligand culminating in the identification of several dual 5-HT1A and 5-HT7 receptor ligands. Compound 16, a butyrophenone derivative of tetrahydroisoquinoline (THIQ), was identified as the most potent agent with low nanomolar binding affinities to both receptors. Interestingly, compound 16 also displayed moderate affinity to other clinically relevant dopamine receptors. Thus, it is anticipated that compound 16 may serve as a lead for further exploitation in our quest to identify new ligands with the potential to treat diseases of CNS origin. PMID:27312422

  5. [UGT1A1 Genotyping for Proper Use of Irinotecan].

    PubMed

    Matsuoka, Ayumu; Ando, Yuichi

    2015-07-01

    Irinotecan is a camptothecin analog used worldwide for a broad range of solid tumors, including colorectal and lung cancers. It can cause severe adverse drug reactions, such as neutropenia or diarrhea. Irinotecan is metabolized to form active SN-38, which is further conjugated and detoxified by the UDP-glucuronosyltransferase (UGT) 1A1 enzyme. Recent pharmacogenetic studies on irinotecan have revealed the impact of UGT1A1 polymorphisms on severe adverse effects. A variant in the promoter of the UGT1A1 gene, the UGT1A1 *28 allele, has been extensively studied, and pharmacogenetic relationships between the variant and severe toxicities of irinotecan have been reported. The US FDA and pharmaceutical companies revised the irinotecan label in 2005, and it now includes homozygosity for the UGT1A1*28 genotype as one of the risk factors for severe neutropenia. A variant in exon 1 of the UGT1A1 gene, the UGT1A1*6 allele, mainly found in East Asians, is also an important risk factor associated with severe neutropenia. The concurrence of UGT1A1*28 and UGT1A1*6, even when heterozygous, markedly alters the disposition of irinotecan, potentially increasing toxicity, which is now written on the label of irinotecan in Japan. For patients showing homozygosity for UGT1A1*28, *6, or compound heterozygosity for UGT1A1*6 and *28, dose reduction of irinotecan is strongly recommended. Genotyping tests for UGT1A1 *6 and *28 have been approved in Japan and are currently used in oncology practice. Moreover, a recent Phase 2 trial for FOLFIRINOX in Japan excluded patients who showed homozygosity for UGT1A1*28, *6, or compound heterozygosity for UGT1A1*6 and *28. At present, irinotecan chemotherapy based on a patient's UGT1A1 genetic status is scientifically reasonable. PMID:26591441

  6. 14 CFR 27.602 - Critical parts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Critical parts. 27.602 Section 27.602 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: NORMAL CATEGORY ROTORCRAFT Design and Construction General § 27.602 Critical parts. (a) Critical part. A critical part is a part,...

  7. 14 CFR 29.602 - Critical parts.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Critical parts. 29.602 Section 29.602 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: TRANSPORT CATEGORY ROTORCRAFT Design and Construction General § 29.602 Critical parts. (a) Critical part. A critical part is a part,...

  8. Accurate identification of UDP-glucuronosyltransferase 1A1 (UGT1A1) inhibitors using UGT1A1-overexpressing HeLa cells.

    PubMed

    Sun, Hua; Zhou, Xiaotong; Wu, Baojian

    2015-01-01

    1. UDP-glucuronosyltransferase 1A1 (UGT1A1) plays an irreplaceable role in detoxification of bilirubin and many drugs (e.g., SN-38). Here we aimed to explore the potential of UGT1A1-overexpressing HeLa cells (or HeLa1A1 cells) as a tool to accurately identify UGT1A1 inhibitors. 2. Determination of glucuronidation rates (β-estradiol and SN-38 as the substrates) was performed using HeLa1A1 cells and uridine diphosphoglucuronic acid (UDPGA)-supplemented cDNA expressed UGT1A1 enzyme (or microsomes). The inhibitory effects (IC50 values) of 20 structurally diverse compounds on the UGT1A1 activity were determined using HeLa1A1 cells and microsomal incubations. 3. In HeLa1A1 cells, the IC50 values for inhibition of β-estradiol glucuronidation by the tested compounds ranged from 0.33 to 94.6 µM. In the microsomal incubations, the IC50 values ranged from 0.47 to 155 µM. It was found that the IC50 values of all test compounds derived from the cells were well consistent with those from the microsomes (deviated by less than two-fold). Further, the IC50 values from the cells were strongly correlated with those from microsomes (r = 0.944, p < 0.001). Likewise, the IC50 values (0.37-77.3 µM) for inhibition of SN-38 glucuronidation in the cells were close to those (0.42-122 µM) for glucuronidation inhibition in microsomes. A strong correlation was also observed between the two sets of IC50 values (r = 0.978, p < 0.001). 4. In conclusion, UGT1A1-overexpressing HeLa cells were an appropriate tool to accurately depict the inhibition profiles of chemicals against UGT1A1. PMID:26068529

  9. The tetraspanin D6.1A and its molecular partners on rat carcinoma cells

    PubMed Central

    2005-01-01

    Tetraspanins function as molecular organizers of multi-protein complexes by assembling primary complexes of a relatively low mass into extensive networks involved in cellular signalling. In this paper, we summarize our studies performed on the tetraspanin D6.1A/CO-029/TM4SF3 expressed by rat carcinoma cells. Primary complexes of D6.1A are almost indistinguishable from complexes isolated with anti-CD9 antibody. Indeed, both tetraspanins directly associate with each other and with a third tetraspanin, CD81. Moreover, FPRP (prostaglandin F2α receptor-regulatory protein)/EWI-F/CD9P-1), an Ig superfamily member that has been described to interact with CD9 and CD81, is also a prominent element in D6.1A complexes. Primary complexes isolated with D6.1A-specific antibody are clearly different from complexes containing the tetraspanin CD151. CD151 is found to interact only with D6.1A if milder conditions, i.e. lysis with LubrolWX instead of Brij96, are applied to disrupt cellular membranes. CD151 probably mediates the interaction of D6.1A primary complexes with α3β1 integrin. In addition, two other molecules were identified to be part of D6.1A complexes at this higher level of association: type II phosphatidylinositol 4-kinase and EpCAM, an epithelial marker protein overexpressed by many carcinomas. The characterization of the D6.1A core complex and additional more indirect interactions will help to elucidate the role in tumour progression and metastasis attributed to D6.1A. PMID:15725074

  10. The Growth and Tumor Suppressors NORE1A and RASSF1A Are Targets for Calpain-Mediated Proteolysis

    PubMed Central

    Kuznetsov, Sergey; Khokhlatchev, Andrei V.

    2008-01-01

    Background NORE1A and RASSF1A are growth and tumour suppressors inactivated in a variety of cancers. Methylation of NORE1A and RASSF1A promoters is the predominant mechanism for downregulation of these proteins; however, other mechanisms are likely to exist. Methodology/Principal Findings Here we describe a proteolysis of NORE1A and RASSF1A by calpains as alternative mechanism of their downregulation. Extracts of H358 cell line, a human bronchoalveolar carcinoma, and H460, a large cell carcinoma, were capable of proteolysis of NORE1A protein in the calpain-dependent manner. Likewise, RASSF1A tumor suppressor was proteolyzed by the H358 cell extract. Addition of calpain inhibitor to H358 and H460 cells growing in tissue culture resulted in re-expression of endogenous NORE1A. A survey of 10 human lung tumours revealed that three of them contain an activity capable of inducing NORE1A degradation. Conclusions/Significance Thus, degradation by calpains is a novel mechanism for downregulation of NORE1A and RASSF1A proteins and might be the mechanism allowing cancer cells to escape growth suppression. PMID:19098985

  11. Strong synergistic induction of CYP1A1 expression by andrographolide plus typical CYP1A inducers in mouse hepatocytes

    SciTech Connect

    Jaruchotikamol, Atika; Jarukamjorn, Kanokwan Sirisangtrakul, Wanna; Sakuma, Tsutomu; Kawasaki, Yuki; Nemoto, Nobuo

    2007-10-15

    The effects of andrographolide, the major diterpenoid constituent of Andrographis paniculata, on the expression of cytochrome P450 superfamily 1 members, including CYP1A1, CYP1A2, and CYP1B1, as well as on aryl hydrocarbon receptor (AhR) expression in primary cultures of mouse hepatocytes were investigated in comparison with the effects of typical CYP1A inducers, including benz[a]anthracene, {beta}-naphthoflavone, and 2,3,7,8-tetrachlorodibenzo-p-dioxin. Andrographolide significantly induced the expression of CYP1A1 and CYP1A2 mRNAs in a concentration-dependent manner, as did the typical CYP1A inducers, but did not induce that of CYP1B1 or AhR. Interestingly, andrographolide plus the typical CYP1A inducers synergistically induced CYP1A1 expression, and the synergism was blocked by an AhR antagonist, resveratrol. The CYP1A1 enzyme activity showed a similar pattern of induction. This is the first report that shows that andrographolide has a potency to induce CYP1A1 enzyme and indicates that andrographolide could be a very useful compound for investigating the regulatory mechanism of the CYP1A1 induction pathway. In addition, our findings suggest preparing advice for rational administration of A. paniculata, according to its ability to induce CYP1A1 expression.

  12. The effect of the CYP1A2 *1F mutation on CYP1A2 inducibility in pregnant women

    PubMed Central

    Nordmark, Anna; Lundgren, Stefan; Ask, Birgitta; Granath, Fredrik; Rane, Anders

    2002-01-01

    Aims To investigate the influence of the CYP1A2*1F mutation on CYP1A2 activity in smoking and nonsmoking pregnant women. Methods Pregnant women (n = 904) who served as control subjects in a case-control study of early fetal loss were investigated. They were phenotyped for CYP1A2 using dietary caffeine and the urinary ratio AFMU + 1X + 1 U/1,7 U. An assay for CYP1A2*1F using 5′-nuclease assay (Taqman) was developed to genotype the population. Results The frequencies of *1 A and *1F alleles among Swedish women were 0.29 and 0.71, respectively. There was no statistically significant difference in CYP1A2 activity between the genotypes, although a trend towards enhanced activity was observed in *1F/*1F (log MRc 0.77) and *1F/*1 A (log MRc 0.82) genotypes compared with the *1 A/*1 A genotype (log MRc 0.71) (anovaP = 0.07). The mean difference between the *1 A homozygotes and the heterozygotes was 0.11 [95% confidence interval of the difference: (−0.21, −0.01)] and that between the *1 A and *1F homozygotes was 0.05 [95% confidence interval of the difference: (−0.13, 0.03)]. No significant effect (P = 0.22) of the *1F on CYP1A2 activity was observed in smokers, tested using an interaction term (smoking * genotype) in the anova model (*1F/*1F log MRc 0.79, *1F/*1 A log MRc 0.86, and *1 A/*1 A log MRc 0.73). In smokers, there was no difference in ratio between homozygotes for the *1 A and *1F alleles [mean difference −0.06; 95% confidence interval of the difference: −0.22, 0.11] or between *1 A/*1 A and *1 A/*1F genotypes [mean difference −0.13; 95% confidence interval of the difference: −0.29, 0.04]. Conclusions The effect of the CYP1A2*1F mutation on CYP1A2 activity in smoking pregnant women could not be confirmed. PMID:12445029

  13. Effects of Hypoxia Exposure on Hepatic Cytochrome P450 1A (CYP1A) Expression in Atlantic Croaker: Molecular Mechanisms of CYP1A Down-Regulation

    PubMed Central

    Rahman, Md. Saydur; Thomas, Peter

    2012-01-01

    Hypoxia-inducible factor-α (HIF-α) and cytochrome P450 1A (CYP1A) are biomarkers of environmental exposure to hypoxia and organic xenobiotic chemicals that act through the aryl hydrocarbon receptor, respectively. Many aquatic environments heavily contaminated with organic chemicals, such as harbors, are also hypoxic. Recently, we and other scientists reported HIF-α genes are upregulated by hypoxia exposure in aquatic organisms, but the molecular mechanisms of hypoxia regulation of CYP1A expression have not been investigated in teleost fishes. As a first step in understanding the molecular mechanisms of hypoxia modulation of CYP1A expression in fish, we characterized CYP1A cDNA from croaker liver. Hypoxia exposure (dissolved oxygen, DO: 1.7 mg/L for 2 to 4 weeks) caused significant decreases in hepatic CYP1A mRNA and protein levels compared to CYP1A levels in fish held in normoxic conditions. In vivo studies showed that the nitric oxide (NO)-donor, S-nitroso-N-acetyl-DL-penicillamine, significantly decreased CYP1A expression in croaker livers, whereas the competitive inhibitor of NO synthase (NOS), Nω-nitro-L-arginine methyl ester, restored CYP1A mRNA and protein levels in hypoxia-exposed (1.7 mg DO/L for 4 weeks) fish. In vivo hypoxia exposure also markedly increased interleukin-1β (IL-1β, a cytokine), HIF-2α mRNA and endothelial NOS (eNOS) protein levels in croaker livers. Pharmacological treatment with vitamin E, an antioxidant, lowered the IL-1β, HIF-2α mRNA and eNOS protein levels in hypoxia-exposed fish and completely reversed the down-regulation of hepatic CYP1A mRNA and protein levels in response to hypoxia exposure. These results suggest that hypoxia-induced down-regulation of CYP1A is due to alterations of NO and oxidant status, and cellular IL-1β and HIF-α levels. Moreover, the present study provides the first evidence of a role for antioxidants in hepatic eNOS and IL-1β regulation in aquatic vertebrates during hypoxic stress. PMID:22815834

  14. X-pinch. Part I

    NASA Astrophysics Data System (ADS)

    Pikuz, S. A.; Shelkovenko, T. A.; Hammer, D. A.

    2015-04-01

    Results of experimental studies of the X-pinch since its invention and implementation in 1982 at the Lebedev Physical Institute are presented. The concept of the X-pinch arose in the course of innovative experiments on studying the generation of hot dense plasma in nanosecond Z-pinches. The main idea was to localize the region occupied by the plasma and stabilize the moment of its formation. This was achieved by using a load in the form of crossed wires. The resulting plasma object turned out to be so interesting that a new scientific direction appeared in plasma physics. At present, studies in this direction are being performed in many laboratories worldwide. The term X-pinch became conventional, and sections devoted to its study are always present at plasma conferences. X-pinch is not only a very interesting scientific object, but also a unique source of X-ray emission with extreme parameters. The use of X-pinches for point-projection X-ray radiography of high-energy-density objects provided many new experimental results. In some cases, the concepts of the processes occurring in matter upon fast energy deposition changed dramatically. The review consists of two parts. The first part briefly outlines the history of creation and studies of X-pinches, describes the diagnostic techniques and devices developed during these studies, and presents the main results obtained in studying the physical processes occurring in the X-pinch. The second part is devoted to the results of detailed studies of the X-pinch hot spot—the region where the highest plasma parameters are achieved and which is a source of X-ray emission with extreme parameters. Some results of X-pinch simulations are also presented.

  15. X-pinch. Part I

    SciTech Connect

    Pikuz, S. A. Shelkovenko, T. A.; Hammer, D. A.

    2015-04-15

    Results of experimental studies of the X-pinch since its invention and implementation in 1982 at the Lebedev Physical Institute are presented. The concept of the X-pinch arose in the course of innovative experiments on studying the generation of hot dense plasma in nanosecond Z-pinches. The main idea was to localize the region occupied by the plasma and stabilize the moment of its formation. This was achieved by using a load in the form of crossed wires. The resulting plasma object turned out to be so interesting that a new scientific direction appeared in plasma physics. At present, studies in this direction are being performed in many laboratories worldwide. The term X-pinch became conventional, and sections devoted to its study are always present at plasma conferences. X-pinch is not only a very interesting scientific object, but also a unique source of X-ray emission with extreme parameters. The use of X-pinches for point-projection X-ray radiography of high-energy-density objects provided many new experimental results. In some cases, the concepts of the processes occurring in matter upon fast energy deposition changed dramatically. The review consists of two parts. The first part briefly outlines the history of creation and studies of X-pinches, describes the diagnostic techniques and devices developed during these studies, and presents the main results obtained in studying the physical processes occurring in the X-pinch. The second part is devoted to the results of detailed studies of the X-pinch hot spot—the region where the highest plasma parameters are achieved and which is a source of X-ray emission with extreme parameters. Some results of X-pinch simulations are also presented.

  16. Understanding Radiation Thermometry. Part II

    NASA Technical Reports Server (NTRS)

    Risch, Timothy K.

    2015-01-01

    This document is a two-part course on the theory and practice of radiation thermometry. Radiation thermometry is the technique for determining the temperature of a surface or a volume by measuring the electromagnetic radiation it emits. This course covers the theory and practice of radiative thermometry and emphasizes the modern application of the field using commercially available electronic detectors and optical components. The course covers the historical development of the field, the fundamental physics of radiative surfaces, along with modern measurement methods and equipment.

  17. Understanding Radiation Thermometry. Part I

    NASA Technical Reports Server (NTRS)

    Risch Timothy K.

    2015-01-01

    This document is a two-part course on the theory and practice of radiation thermometry. Radiation thermometry is the technique for determining the temperature of a surface or a volume by measuring the electromagnetic radiation it emits. This course covers the theory and practice of radiative thermometry and emphasizes the modern application of the field using commercially available electronic detectors and optical components. The course covers the historical development of the field, the fundamental physics of radiative surfaces, along with modern measurement methods and equipment.

  18. Selective inhibition of the kinase DYRK1A by targeting its folding process.

    PubMed

    Kii, Isao; Sumida, Yuto; Goto, Toshiyasu; Sonamoto, Rie; Okuno, Yukiko; Yoshida, Suguru; Kato-Sumida, Tomoe; Koike, Yuka; Abe, Minako; Nonaka, Yosuke; Ikura, Teikichi; Ito, Nobutoshi; Shibuya, Hiroshi; Hosoya, Takamitsu; Hagiwara, Masatoshi

    2016-01-01

    Autophosphorylation of amino-acid residues is part of the folding process of various protein kinases. Conventional chemical screening of mature kinases has missed inhibitors that selectively interfere with the folding process. Here we report a cell-based assay that evaluates inhibition of a kinase at a transitional state during the folding process and identify a folding intermediate-selective inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), which we refer to as FINDY. FINDY suppresses intramolecular autophosphorylation of Ser97 in DYRK1A in cultured cells, leading to its degradation, but does not inhibit substrate phosphorylation catalysed by the mature kinase. FINDY also suppresses Ser97 autophosphorylation of recombinant DYRK1A, suggesting direct inhibition, and shows high selectivity for DYRK1A over other DYRK family members. In addition, FINDY rescues DYRK1A-induced developmental malformations in Xenopus laevis embryos. Our study demonstrates that transitional folding intermediates of protein kinases can be targeted by small molecules, and paves the way for developing novel types of kinase inhibitors. PMID:27102360

  19. Severe phenotypes in a Charcot-Marie-Tooth 1A patient with PMP22 triplication.

    PubMed

    Kim, Sung Min; Lee, Jinho; Yoon, Bo Ram; Kim, Ye Jin; Choi, Byung-Ok; Chung, Ki Wha

    2015-02-01

    Charcot-Marie-Tooth disease (CMT) is a genetically and clinically heterogeneous hereditary motor and sensory neuropathy signified by a distal symmetric polyneuropathy. The most frequent subtype is type 1A (CMT1A) caused by duplication in chromosome 17p12 that includes PMP22. This study reports a woman with a family history of CMT1A due to PMP22 duplication. However, she presented with a more severe phenotype than her sibling or ancestors and was found to have a PMP22 triplication instead of the duplication. This was caused by de novo mutation on her affected mother's duplication chromosome. Her lower limb magnetic resonance imaging revealed severe diffused atrophy and fatty replacement. However, her affected sister with typical PMP22 duplication showed almost intact lower limb. Triplication patient's median motor nerve conduction velocity was far lower compared with her sister. Her onset age was faster (8 years) than her sister (42 years). CMT1A triplication might be generated by a female-specific chromosomal rearrangement mechanism that is different from the frequent paternal-originated CMT1A duplication. It also suggests that the wide phenotypic variation of CMT1A might be partly caused by unstable genomic rearrangement, including PMP22 triplication. PMID:25500726

  20. Identification and phylogenetic analysis of novel cytochrome P450 1A genes from ungulate species.

    PubMed

    Darwish, Wageh Sobhy; Kawai, Yusuke; Ikenaka, Yoshinori; Yamamoto, Hideaki; Muroya, Tarou; Ishizuka, Mayumi

    2010-09-01

    As part of an ongoing effort to understand the biological response of wild and domestic ungulates to different environmental pollutants such as dioxin-like compounds, cDNAs encoding for CYP1A1 and CYP1A2 were cloned and characterized. Four novel CYP1A cDNA fragments from the livers of four wild ungulates (elephant, hippopotamus, tapir and deer) were identified. Three fragments from hippopotamus, tapir and deer were classified as CYP1A2, and the other fragment from elephant was designated as CYP1A1/2. The deduced amino acid sequences of these fragment CYP1As showed identities ranging from 76 to 97% with other animal CYP1As. The phylogenetic analysis of these fragments showed that both elephant and hippopotamus CYP1As made separate branches, while tapir and deer CYP1As were located beside that of horse and cattle respectively in the phylogenetic tree. Analysis of dN/dS ratio among the identified CYP1As indicated that odd toed ungulate CYP1A2s were exposed to different selection pressure. PMID:20448415

  1. Selective inhibition of the kinase DYRK1A by targeting its folding process

    PubMed Central

    Kii, Isao; Sumida, Yuto; Goto, Toshiyasu; Sonamoto, Rie; Okuno, Yukiko; Yoshida, Suguru; Kato-Sumida, Tomoe; Koike, Yuka; Abe, Minako; Nonaka, Yosuke; Ikura, Teikichi; Ito, Nobutoshi; Shibuya, Hiroshi; Hosoya, Takamitsu; Hagiwara, Masatoshi

    2016-01-01

    Autophosphorylation of amino-acid residues is part of the folding process of various protein kinases. Conventional chemical screening of mature kinases has missed inhibitors that selectively interfere with the folding process. Here we report a cell-based assay that evaluates inhibition of a kinase at a transitional state during the folding process and identify a folding intermediate-selective inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A), which we refer to as FINDY. FINDY suppresses intramolecular autophosphorylation of Ser97 in DYRK1A in cultured cells, leading to its degradation, but does not inhibit substrate phosphorylation catalysed by the mature kinase. FINDY also suppresses Ser97 autophosphorylation of recombinant DYRK1A, suggesting direct inhibition, and shows high selectivity for DYRK1A over other DYRK family members. In addition, FINDY rescues DYRK1A-induced developmental malformations in Xenopus laevis embryos. Our study demonstrates that transitional folding intermediates of protein kinases can be targeted by small molecules, and paves the way for developing novel types of kinase inhibitors. PMID:27102360

  2. RCS Analysis of Plate Geometries, parts 1 and 2

    NASA Technical Reports Server (NTRS)

    Balanis, Constantine A.; Polka, Lesley A.; Polycarpou, Anastasis C.

    1993-01-01

    High-frequency techniques for Radar Cross Section (RCS) prediction of plate geometries and a physical optics/equivalent currents model for the RCS of trihedral corner reflectors are addressed. In part 1, a Uniform Theory of Diffraction (UTD) model for the principal-plane radar cross section (RCS) of a perfectly conducting, rectangular plate coated on one side with an electrically thin, lossy dielectric is presented. In part 2, the scattering in the interior regions of both square and triangular trihedral corner reflectors are examined.

  3. Seizure Termination by Acidosis Depends on ASIC1a

    PubMed Central

    Ziemann, Adam E.; Schnizler, Mikael K.; Albert, Gregory W.; Severson, Meryl A.; Howard, Matthew A.; Welsh, Michael J.; Wemmie, John A.

    2008-01-01

    SUMMARY Most seizures stop spontaneously. However, the molecular mechanisms remain unknown. Earlier observations that seizures reduce brain pH and that acidosis inhibits seizures indicated that acidosis halts epileptic activity. Because acid–sensing ion channel–1a (ASIC1a) shows exquisite sensitivity to extracellular pH and regulates neuron excitability, we hypothesized that acidosis might activate ASIC1a to terminate seizures. Disrupting mouse ASIC1a increased the severity of chemoconvulsant–induced seizures, whereas overexpressing ASIC1a had the opposite effect. ASIC1a did not affect seizure threshold or onset, but shortened seizure duration and prevented progression. CO2 inhalation, long known to lower brain pH and inhibit seizures, also required ASIC1a to interrupt tonic–clonic seizures. Acidosis activated inhibitory interneurons through ASIC1a, suggesting that ASIC1a might limit seizures by increasing inhibitory tone. These findings identify ASIC1a as a key element in seizure termination when brain pH falls. The results suggest a molecular mechanism for how the brain stops seizures and suggest new therapeutic strategies. PMID:18536711

  4. NASA EEE Parts 2014 Year in Review

    NASA Technical Reports Server (NTRS)

    Lee, Sara-Anne

    2015-01-01

    The NASA Electronic Parts and Packaging Program continue to support Electrical, Electronic and Electromagnetic Parts for the agency with an eventful year of workshops, innovations, testing and challenges.

  5. Facilitation of learning: part 2.

    PubMed

    Warburton, Tyler; Houghton, Trish; Barry, Debbie

    2016-04-27

    The previous article in this series of 11, Facilitation of learning: part 1, reviewed learning theories and how they relate to clinical practice. Developing an understanding of these theories is essential for mentors and practice teachers to enable them to deliver evidence-based learning support. This is important given that effective learning support is dependent on an educator who possesses knowledge of their specialist area as well as the relevent tools and methods to support learning. The second domain of the Nursing and Midwifery Council's Standards to Support Learning and Assessment in Practice relates to the facilitation of learning. To fulfil this domain, mentors and practice teachers are required to demonstrate their ability to recognise the needs of learners and provide appropriate support to meet those needs. This article expands on some of the discussions from part 1 of this article and considers these from a practical perspective, in addition to introducing some of the tools that can be used to support learning. PMID:27191319

  6. Standards in neurosonology. Part II

    PubMed Central

    Tomczyk, Tomasz; Luchowski, Piotr; Kozera, Grzegorz; Kaźmierski, Radosław; Stelmasiak, Zbigniew

    2016-01-01

    The paper presents standards related to ultrasound imaging of the cerebral vasculature and structures. The aim of this paper is to standardize both the performance and description of ultrasound imaging of the extracranial and intracranial cerebral arteries as well as a study of a specific brain structure, i.e. substantia nigra hyperechogenicity. The following aspects are included in the description of standards for each ultrasonographic method: equipment requirements, patient preparation, study technique and documentation as well as the required elements of ultrasound description. Practical criteria for the diagnosis of certain pathologies in accordance with the latest literature were also presented. Furthermore, additional comments were included in some of the sections. Part I discusses standards for the performance, documentation and description of different ultrasound methods (Duplex, Doppler). Part II and III are devoted to standards for specific clinical situations (vasospasm, monitoring after the acute stage of stroke, detection of a right-to-left shunts, confirmation of the arrest of the cerebral circulation, an assessment of the functional efficiency of circle of Willis, an assessment of the cerebrovascular vasomotor reserve as well as the measurement of substantia nigra hyperechogenicity). PMID:27104002

  7. Standards in neurosonology. Part III

    PubMed Central

    Tomczyk, Tomasz; Luchowski, Piotr; Kozera, Grzegorz; Kaźmierski, Radosław; Stelmasiak, Zbigniew

    2016-01-01

    The paper presents standards related to ultrasound imaging of the cerebral vasculature and structures. The aim of this paper is to standardize both the performance and description of ultrasound imaging of the extracranial and intracranial cerebral arteries as well as a study of a specific brain structure, i.e. substantia nigra hyperechogenicity. The following aspects are included in the description of standards for each ultrasonographic method: equipment requirements, patient preparation, study technique and documentation as well as the required elements of ultrasound description. Practical criteria for the diagnosis of certain pathologies in accordance with the latest literature were also presented. Furthermore, additional comments were included in some of the sections. Part I discusses standards for the performance, documentation and description of different ultrasound methods (Duplex, Doppler). Part II and III are devoted to standards for specific clinical situations (vasospasm, monitoring after the acute stage of stroke, detection of a right-to-left shunts, confirmation of the arrest of the cerebral circulation, an assessment of the functional efficiency of circle of Willis, an assessment of the cerebrovascular vasomotor reserve as well as the measurement of substantia nigra hyperechogenicity). PMID:27446600

  8. Future Jet Technologies, Part C

    NASA Astrophysics Data System (ADS)

    Gal-Or, Benjamin

    2013-06-01

    This updated, PART C REVIEW, covers the dangerous global spread of JS-stealth, drone technology [1-91], canard-free, stealth, new agile drones and the highly debated, 480 billion F-35 International Program as reported on March 13, 2013 to the U.S. Congress [92]. Due to serious design issues, spiraling high costs and years in delays, alternatives are analyzed here, depicted and proposed, mainly from the propulsion-design point of view. These include fleets of low-cost, stealth, jet-steered-drones mixed with non-stealthy, low-cost, ready-to-be-delivered, U.S. or European or Russian fighter aircraft. Can a few F-35s win against large fleets of stealth agile drones? To understand the dangers and critical issues involved, the author's own, past classified information is partly disclosed, while resorting to images in Figs. 2(a) and 2(b) taken from his book [2] and from Wikipedia, the "Free Encyclopedia", in all other images.

  9. Standards in neurosonology. Part III.

    PubMed

    Wojczal, Joanna; Tomczyk, Tomasz; Luchowski, Piotr; Kozera, Grzegorz; Kaźmierski, Radosław; Stelmasiak, Zbigniew

    2016-06-01

    The paper presents standards related to ultrasound imaging of the cerebral vasculature and structures. The aim of this paper is to standardize both the performance and description of ultrasound imaging of the extracranial and intracranial cerebral arteries as well as a study of a specific brain structure, i.e. substantia nigra hyperechogenicity. The following aspects are included in the description of standards for each ultrasonographic method: equipment requirements, patient preparation, study technique and documentation as well as the required elements of ultrasound description. Practical criteria for the diagnosis of certain pathologies in accordance with the latest literature were also presented. Furthermore, additional comments were included in some of the sections. Part I discusses standards for the performance, documentation and description of different ultrasound methods (Duplex, Doppler). Part II and III are devoted to standards for specific clinical situations (vasospasm, monitoring after the acute stage of stroke, detection of a right-to-left shunts, confirmation of the arrest of the cerebral circulation, an assessment of the functional efficiency of circle of Willis, an assessment of the cerebrovascular vasomotor reserve as well as the measurement of substantia nigra hyperechogenicity). PMID:27446600

  10. Abiotic and biotic stress tolerance in Arabidopsis overexpressing the multiprotein bridging factor 1a (MBF1a) transcriptional coactivator gene.

    PubMed

    Kim, Min-Jung; Lim, Gah-Hyun; Kim, Eun-Seon; Ko, Chang-Beom; Yang, Kwang-Yeol; Jeong, Jin-An; Lee, Myung-Chul; Kim, Cheol Soo

    2007-03-01

    We conducted a genetic yeast screen to identify salt tolerance (SAT) genes in a maize kernel cDNA library. During the screening, we identified a maize clone (SAT41) that seemed to confer elevated salt tolerance in comparison to control cells. SAT41 cDNA encodes a 16-kDa protein which is 82.4% identical to the Arabidopsis Multiprotein bridging factor 1a (MBF1a) transcriptional coactivator gene. To further examine salinity tolerance in Arabidopsis, we functionally characterized the MBF1a gene and found that dehydration as well as heightened glucose (Glc) induced MBF1a expression. Constitutive expression of MBF1a in Arabidopsis led to elevated salt tolerance in transgenic lines. Interestingly, plants overexpressing MBF1a exhibited insensitivity to Glc and resistance to fungal disease. Our results suggest that MBF1a is involved in stress tolerance as well as in ethylene and Glc signaling in Arabidopsis. PMID:17234157

  11. CD1a Reactivity in Non-neoplastic Adenohypophysis.

    PubMed

    Pisapia, David J; Rosenblum, Marc K; Lavi, Ehud

    2016-06-01

    Within the differential diagnosis of patients presenting with sellar or suprasellar lesions is Langerhans cell histiocytosis (LCH). CD1a staining is frequently used to identify the presence of an abnormal proliferation of Langerhans cells on histologic sections and contributes to the diagnosis of LCH. Here, we report that the MTB-1 monoclonal antibody against the CD1a antigen reacts to native adenohypophyseal epithelial cells. We show that immunohistochemistry for CD1a exhibits strong positivity in all autopsy and surgically resected non-neoplastic adenohypophysis tested. Thus, CD1a positivity by itself should be interpreted with caution, and we recommend the routine use of a panel of stains including CD1a, Langerin, and synaptophysin in conjunction with morphologic analysis before a diagnosis of LCH is rendered. In addition, we find that pituitary adenomas fail to stain for CD1a prompting consideration of the utility of this stain as a marker for non-neoplastic gland. PMID:26999501

  12. 15 CFR 740.10 - License Exception Servicing and replacement of parts and equipment (RPL).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the ITAR, i.e., described on the United States Munitions List (22 CFR 121.1). (a) Parts, components... isotopes of source and special nuclear materials, or the fabrication of nuclear reactor fuel...

  13. Microbial Induction of Inflammatory Bowel Disease Associated Gene TL1A (TNFSF15) in Antigen Presenting Cells

    PubMed Central

    Shih, David Q.; Kwan, Lola Y.; Chavez, Valerie; Cohavy, Offer; Gonsky, Rivkah; Chang, Elmer Y.; Chang, Christopher; Elson, Charles O.; Targan, Stephan R.

    2010-01-01

    Summary TL1A is a member of the TNF superfamily and its expression is increased in the mucosa of inflammatory bowel disease (IBD) patients. Neutralizing anti-mouse TL1A Ab attenuates chronic colitis in two T cell driven murine models, suggesting that TL1A is a central modulator of gut mucosal inflammation in IBD. We showed previously that TL1A is induced by immune complexes (IC) via the FcγR signaling pathway. In this study, we report that multiple bacteria, including gram negative organisms (E. coli, E. coli Nissle 1917, S. typhimurium), gram positive organisms (L. monocytogenes, S. epidermidis), partial anaerobes (C. jejuni), and obligate anaerobes (B. thetaiotaomicron, B. breve, Clostridium A4) activate TL1A expression in human APC, including monocytes and monocyte-derived DC. Bacterially induced TL1A mRNA expression correlates with the detection of TL1A protein levels. TL1A induced by bacteria is mediated in part by the TLR signaling pathway and inhibited by downstream blockade of p38 MAPK and NF-κB activation. Microbial induction of TL1A production by human APC potentiated CD4+ T cell effector function by augmenting IFN-γ production. Our findings suggest a role for TL1A in pro-inflammatory APC-T cell interactions and implicate TL1A in host responses to enteric microorganisms. PMID:19839006

  14. New insights into heterogeneity of peritoneal B-1a cells.

    PubMed

    Wang, Hongsheng; Lin, Jian-xin; Li, Peng; Skinner, Jeff; Leonard, Warren J; Morse, Herbert C

    2015-12-01

    Peritoneal B-1a cells are characterized by their expression of CD5 and enrichment for germline-encoded IgM B cell receptors. Early studies showing expression of a diverse array of VDJ sequences among purified B-1a cells provided a molecular basis for understanding the heterogeneity of the B-1a cell repertoire. Antigen-driven positive selection and the identification of B-1a specific progenitors suggest multiple origins of B-1a cells. The introduction of new markers such as PD-L2, CD25, CD73, and PC1 (plasma cell alloantigen 1, also known as ectonucleotide phosphodiesterase/pyrophosphatase 1) further helped to identify phenotypically and functionally distinct B-1a subsets. Among many B-1a subsets defined by these new markers, PC1 is unique in that it subdivides B-1a cells into PC1(hi) and PC1(lo) subpopulations with distinct functions, such as production of natural IgM and gut IgA, response to the pneumococcal antigen PPS-3, secretion of interleukin-10, and support for T helper 1 (TH 1) cell differentiation. RNA sequencing of these subsets revealed differential expression of genes involved in cellular movement and immune cell trafficking. We will discuss these new insights underlying the heterogeneous nature of the B-1a cell repertoire. PMID:25988856

  15. Aldehyde dehydrogenase 1A1 in stem cells and cancer

    PubMed Central

    Tomita, Hiroyuki; Tanaka, Kaori; Tanaka, Takuji; Hara, Akira

    2016-01-01

    The human genome contains 19 putatively functional aldehyde dehydrogenase (ALDH) genes, which encode enzymes critical for detoxification of endogenous and exogenous aldehyde substrates through NAD(P)+-dependent oxidation. ALDH1 has three main isotypes, ALDH1A1, ALDH1A2, and ALDH1A3, and is a marker of normal tissue stem cells (SC) and cancer stem cells (CSC), where it is involved in self-renewal, differentiation and self-protection. Experiments with murine and human cells indicate that ALDH1 activity, predominantly attributed to isotype ALDH1A1, is tissue- and cancer-specific. High ALDH1 activity and ALDH1A1 overexpression are associated with poor cancer prognosis, though high ALDH1 and ALDH1A1 levels do not always correlate with highly malignant phenotypes and poor clinical outcome. In cancer therapy, ALDH1A1 provides a useful therapeutic CSC target in tissue types that normally do not express high levels of ALDH1A1, including breast, lung, esophagus, colon and stomach. Here we review the functions and mechanisms of ALDH1A1, the key ALDH isozyme linked to SC populations and an important contributor to CSC function in cancers, and we outline its potential in future anticancer strategies. PMID:26783961

  16. Photodissociation of N2O: excitation of 1A" states.

    PubMed

    Schinke, Reinhard; Schmidt, Johan A

    2012-11-26

    We investigate the contributions of the lowest two (1)A" states in the UV photodissociation of N(2)O employing three-dimensional potential energy surfaces and transition dipole moment functions. Because the transition dipole moments are much smaller than for the 2 (1)A' state, we conclude that excitation of the (1)A" states has a marginal effect. The dense vibrational spectrum of the quasi-bound 2(1)A" state possibly explains some of the tiny, noise-like structures of the measured absorption spectrum. PMID:22536943

  17. Stiffness of modified Type 1a linear external skeletal fixators.

    PubMed

    Reaugh, H F; Rochat, M C; Bruce, C W; Galloway, D S; Payton, M E

    2007-01-01

    Modifications of a Type 1a external skeletal fixator (ESF) frame were evaluated by alternately placing transfixation pins on opposite sides of the connecting rod (Type 1a-MOD) or by placing additional connecting rods on either of the two inside (Type 1a-INSIDE) or two outside (Type 1a-OUTSIDE) transfixation pins. The objective of this study was to evaluate the stiffness of these modifications in terms of axial compression (AC), cranial-caudal bending (CCB), and medial-lateral bending (MLB). We hypothesized that these designs would allow significant increase in unilateral frame stiffness, over Type 1a, without proportional increase in frame complexity or technical difficulty of application. All of the ESF frames were constructed using large IMEX SKtrade mark clamps, 3.2 mm threaded fixation pins, 9.5 mm carbon fibre connecting rods and Delrin rods as bone models. Nine, eight pin frames of each design were constructed, and subjected to repetitive non-destructive loading forces (AC, CCB, MLB) using a materials testing machine. Frame construct stiffness for each force (AC, CCB, MLB) was derived from load-deformation curve analysis and displayed in N/mm. Data revealed the 1a-MOD and 1a-OUTSIDE constructs had significantly increased stiffness in CCB and AC as compared to the Type 1a constructs while all of the modified constructs were significantly stiffer in MLB than the Type 1a constructs. PMID:18038001

  18. Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies.

    PubMed

    Carreño, Oriel; Corominas, Roser; Serra, Selma Angèlica; Sintas, Cèlia; Fernández-Castillo, Noèlia; Vila-Pueyo, Marta; Toma, Claudio; Gené, Gemma G; Pons, Roser; Llaneza, Miguel; Sobrido, María-Jesús; Grinberg, Daniel; Valverde, Miguel Ángel; Fernández-Fernández, José Manuel; Macaya, Alfons; Cormand, Bru

    2013-11-01

    Hemiplegic migraine (HM) is a rare and severe subtype of autosomal dominant migraine, characterized by a complex aura including some degree of motor weakness. Mutations in four genes (CACNA1A, ATP1A2, SCN1A and PRRT2) have been detected in familial and in sporadic cases. This genetically and clinically heterogeneous disorder is often accompanied by permanent ataxia, epileptic seizures, mental retardation, and chronic progressive cerebellar atrophy. Here we report a mutation screening in the CACNA1A and ATP1A2 genes in 18 patients with HM. Furthermore, intragenic copy number variant (CNV) analysis was performed in CACNA1A using quantitative approaches. We identified four previously described missense CACNA1A mutations (p.Ser218Leu, p.Thr501Met, p.Arg583Gln, and p.Thr666Met) and two missense changes in the ATP1A2 gene, the previously described p.Ala606Thr and the novel variant p.Glu825Lys. No structural variants were found. This genetic screening allowed the identification of more than 30% of the disease alleles, all present in a heterozygous state. Functional consequences of the CACNA1A-p.Thr501Met mutation, previously described only in association with episodic ataxia, and ATP1A2-p.Glu825Lys, were investigated by means of electrophysiological studies, cell viability assays or Western blot analysis. Our data suggest that both these variants are disease-causing. PMID:24498617

  19. Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies

    PubMed Central

    Carreño, Oriel; Corominas, Roser; Serra, Selma Angèlica; Sintas, Cèlia; Fernández-Castillo, Noèlia; Vila-Pueyo, Marta; Toma, Claudio; Gené, Gemma G; Pons, Roser; Llaneza, Miguel; Sobrido, María-Jesús; Grinberg, Daniel; Valverde, Miguel Ángel; Fernández-Fernández, José Manuel; Macaya, Alfons; Cormand, Bru

    2013-01-01

    Hemiplegic migraine (HM) is a rare and severe subtype of autosomal dominant migraine, characterized by a complex aura including some degree of motor weakness. Mutations in four genes (CACNA1A, ATP1A2, SCN1A and PRRT2) have been detected in familial and in sporadic cases. This genetically and clinically heterogeneous disorder is often accompanied by permanent ataxia, epileptic seizures, mental retardation, and chronic progressive cerebellar atrophy. Here we report a mutation screening in the CACNA1A and ATP1A2 genes in 18 patients with HM. Furthermore, intragenic copy number variant (CNV) analysis was performed in CACNA1A using quantitative approaches. We identified four previously described missense CACNA1A mutations (p.Ser218Leu, p.Thr501Met, p.Arg583Gln, and p.Thr666Met) and two missense changes in the ATP1A2 gene, the previously described p.Ala606Thr and the novel variant p.Glu825Lys. No structural variants were found. This genetic screening allowed the identification of more than 30% of the disease alleles, all present in a heterozygous state. Functional consequences of the CACNA1A-p.Thr501Met mutation, previously described only in association with episodic ataxia, and ATP1A2-p.Glu825Lys, were investigated by means of electrophysiological studies, cell viability assays or Western blot analysis. Our data suggest that both these variants are disease-causing. PMID:24498617

  20. Supernovae. Part I: the events

    NASA Astrophysics Data System (ADS)

    Trimble, Virginia

    1982-10-01

    Since the heroic era of Baade and Zwicky, our understanding of supernovae has advanced in hops and skips rather than steadily. The most recent jump has been into fairly general agreement that observations of Type I's can be interpreted as the manifestation of the decay of about 1Msolar of Ni56 and observations of Type II's as the manifestation of >~1051 ergs deposited at the bottom of a supergiant envelope by core bounce as a central neutron star forms. This paper explores the history of these and other ideas of what is going on in supernovae, the presupernova evolution of the parent stars and binary systems, observed properties of the events, and models for them. A later paper (Part II: the aftermath) will address the results of supernovae-their remnants, production of cosmic rays and gamma rays, nucleosynthesis, and galactic evolution-and the future of supernova research.

  1. Neurofibromatosis: part 2--clinical management.

    PubMed

    Batista, Pollyanna Barros; Bertollo, Eny Maria Goloni; Costa, Danielle de Souza; Eliam, Lucas; Cunha, Karin Soares Gonçalves; Cunha-Melo, José Renan; Darrigo Junior, Luiz Guilherme; Geller, Mauro; Gianordoli-Nascimento, Ingrid Faria; Madeira, Luciana Gonçalves; Mendes, Hérika Martins; Miranda, Débora Marques de; Mata-Machado, Nikolas Andre; Morato, Eric Grossi; Pavarino, Érika Cristina; Pereira, Luciana Baptista; Rezende, Nilton Alves de; Rodrigues, Luíza de Oliveira; Sette, Jorge Bezerra Cavalcanti

    2015-06-01

    Part 1 of this guideline addressed the differential diagnosis of the neurofibromatoses (NF): neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2) and schwannomatosis (SCH). NF shares some features such as the genetic origin of the neural tumors and cutaneous manifestations, and affects nearly 80 thousand Brazilians. Increasing scientific knowledge on NF has allowed better clinical management and reduced rate of complications and morbidity, resulting in higher quality of life for NF patients. Most medical doctors are able to perform NF diagnosis, but the wide range of clinical manifestations and the inability to predict the onset or severity of new features, consequences, or complications make NF management a real clinical challenge, requiring the support of different specialists for proper treatment and genetic counseling, especially in NF2 and SCH. The present text suggests guidelines for the clinical management of NF, with emphasis on NF1. PMID:26083891

  2. Computerized parts list system coordinates engineering releases, parts control, and manufacturing planning

    NASA Technical Reports Server (NTRS)

    Horton, W.; Kinsey, M.

    1967-01-01

    Computerized parts list system compiles and summarize all pertinent and available information on complex new systems. The parts list system consists of three computer subroutines - list of parts, parts numerical sequence list, and specifications list.

  3. Modulation of anxiety by cortical serotonin 1A receptors

    PubMed Central

    Piszczek, Lukasz; Piszczek, Agnieszka; Kuczmanska, Joanna; Audero, Enrica; Gross, Cornelius T.

    2015-01-01

    Serotonin (5-HT) plays an important role in the modulation of behavior across animal species. The serotonin 1A receptor (Htr1a) is an inhibitory G-protein coupled receptor that is expressed both on serotonin and non-serotonin neurons in mammals. Mice lacking Htr1a show increased anxiety behavior suggesting that its activation by serotonin has an anxiolytic effect. This outcome can be mediated by either Htr1a population present on serotonin (auto-receptor) or non-serotonin neurons (hetero-receptor), or both. In addition, both transgenic and pharmacological studies have shown that serotonin acts on Htr1a during development to modulate anxiety in adulthood, demonstrating a function for this receptor in the maturation of anxiety circuits in the brain. However, previous studies have been equivocal about which Htr1a population modulates anxiety behavior, with some studies showing a role of Htr1a hetero-receptor and others implicating the auto-receptor. In particular, cell-type specific rescue and suppression of Htr1a expression in either forebrain principal neurons or brainstem serotonin neurons reached opposite conclusions about the role of the two populations in the anxiety phenotype of the knockout. One interpretation of these apparently contradictory findings is that the modulating role of these two populations depends on each other. Here we use a novel Cre-dependent inducible allele of Htr1a in mice to show that expression of Htr1a in cortical principal neurons is sufficient to modulate anxiety. Together with previous findings, these results support a hetero/auto-receptor interaction model for Htr1a function in anxiety. PMID:25759645

  4. Holding Irregularly Shaped Parts For Machining

    NASA Technical Reports Server (NTRS)

    Hilton, Burt W.; Wilson, Rick R.

    1988-01-01

    Part with complicated, irregular outside contours clamped for precise machining of internal passages with aid of simple method. Exterior of part cast in Rigidex, or equivalent epoxy. Forms wall to be clamped. Interior of part machined to finish of 125 microinches or finer. When machining finished, epoxy melted away by heating part to 200 degree F.

  5. The roles of CC2D1A and HTR1A gene expressions in autism spectrum disorders.

    PubMed

    Sener, Elif Funda; Cıkılı Uytun, Merve; Korkmaz Bayramov, Keziban; Zararsiz, Gokmen; Oztop, Didem Behice; Canatan, Halit; Ozkul, Yusuf

    2016-06-01

    Classical autism belongs to a group of heterogeneous disorders known as autism spectrum disorders (ASD). Autism is defined as a neurodevelopmental disorder, characterized by repetitive stereotypic behaviors or restricted interests, social withdrawal, and communication deficits. Numerous susceptibility genes and chromosomal abnormalities have been reported in association with autism but the etiology of this disorder is unknown in many cases. CC2D1A gene has been linked to mental retardation (MR) in a family with a large deletion before. Intellectual disability (ID) is a common feature of autistic cases. Therefore we aimed to investigate the expressions of CC2D1A and HTR1A genes with the diagnosis of autism in Turkey. Forty-four autistic patients (35 boys, 9 girls) and 27 controls were enrolled and obtained whole blood samples to isolate RNA samples from each participant. CC2D1A and HTR1A gene expressions were assessed by quantitative Real-Time PCR (qRT-PCR) in Genome and Stem Cell Center, Erciyes University. Both expressions of CC2D1A and HTR1A genes studied on ASD cases and controls were significantly different (p < 0.001). The expression of HTR1A was undetectable in the ASD samples. Comparison of ID and CC2D1A gene expression was also found statistically significant (p = 0.028). CC2D1A gene expression may be used as a candidate gene for ASD cases with ID. Further studies are needed to investigate the potential roles of these CC2D1A and HTR1A genes in their related pathways in ASD. PMID:26782176

  6. 26 CFR 1.665(b)-1A - Accumulation distributions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Accumulation distributions. 1.665(b)-1A Section... TAX (CONTINUED) INCOME TAXES Treatment of Excess Distributions of Trusts Applicable to Taxable Years Beginning on Or After January 1, 1969 § 1.665(b)-1A Accumulation distributions. (a) In general. (1) For...

  7. 26 CFR 1.665(b)-1A - Accumulation distributions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Accumulation distributions. 1.665(b)-1A Section... TAX (CONTINUED) INCOME TAXES (CONTINUED) Treatment of Excess Distributions of Trusts Applicable to Taxable Years Beginning on Or After January 1, 1969 § 1.665(b)-1A Accumulation distributions. (a)...

  8. 40 CFR 60.482-1a - Standards: General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Standards: General. 60.482-1a Section... (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW STATIONARY SOURCES Standards of Performance for Equipment Leaks..., Reconstruction, or Modification Commenced After November 7, 2006 § 60.482-1a Standards: General. (a) Each...

  9. Paresev 1-A and Tow Plane with Crew and Pilot

    NASA Technical Reports Server (NTRS)

    1962-01-01

    With the Paresev 1-A and the 450-hp Stearman Sport Biplane as a backdrop the pilot and crew pose for this picture in 1962. Starting at left: On the motorcycle is Walter Whiteside, in the Paresev 1-A is test pilot Milton Thompson, Frank Fedor, Richard Klein, Victor Horton, Tom Kelly, Jr., Fred Harris, owner of the Stearman, John Orahood, and Gary Layton.

  10. 26 CFR 1.666(a)-1A - Amount allocated.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 8 2013-04-01 2013-04-01 false Amount allocated. 1.666(a)-1A Section 1.666(a... Beginning Before January 1, 1969 § 1.666(a)-1A Amount allocated. (a) In general. In the case of a trust that... trusts that may accumulate income or that distribute corpus), section 666(a) prescribes rules...

  11. 26 CFR 1.666(a)-1A - Amount allocated.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 8 2012-04-01 2012-04-01 false Amount allocated. 1.666(a)-1A Section 1.666(a... Beginning Before January 1, 1969 § 1.666(a)-1A Amount allocated. (a) In general. In the case of a trust that... trusts that may accumulate income or that distribute corpus), section 666(a) prescribes rules...

  12. 26 CFR 1.666(a)-1A - Amount allocated.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 8 2014-04-01 2014-04-01 false Amount allocated. 1.666(a)-1A Section 1.666(a... Beginning Before January 1, 1969 § 1.666(a)-1A Amount allocated. (a) In general. In the case of a trust that... trusts that may accumulate income or that distribute corpus), section 666(a) prescribes rules...

  13. 26 CFR 1.666(a)-1A - Amount allocated.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Amount allocated. 1.666(a)-1A Section 1.666(a... Before January 1, 1969 § 1.666(a)-1A Amount allocated. (a) In general. In the case of a trust that is... that may accumulate income or that distribute corpus), section 666(a) prescribes rules for...

  14. 26 CFR 1.666(a)-1A - Amount allocated.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Amount allocated. 1.666(a)-1A Section 1.666(a... Beginning Before January 1, 1969 § 1.666(a)-1A Amount allocated. (a) In general. In the case of a trust that... trusts that may accumulate income or that distribute corpus), section 666(a) prescribes rules...

  15. Method of forming and assembly of parts

    DOEpatents

    Ripley, Edward B.

    2010-12-28

    A method of assembling two or more parts together that may be metal, ceramic, metal and ceramic parts, or parts that have different CTE. Individual parts are formed and sintered from particles that leave a network of interconnecting porosity in each sintered part. The separate parts are assembled together and then a fill material is infiltrated into the assembled, sintered parts using a method such as capillary action, gravity, and/or pressure. The assembly is then cured to yield a bonded and fully or near-fully dense part that has the desired physical and mechanical properties for the part's intended purpose. Structural strength may be added to the parts by the inclusion of fibrous materials.

  16. Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A.

    PubMed

    Pons-Espinal, Meritxell; Martinez de Lagran, Maria; Dierssen, Mara

    2013-12-01

    Hippocampal adult neurogenesis disruptions have been suggested as one of the neuronal plasticity mechanisms underlying learning and memory impairment in Down syndrome (DS). However, it remains unknown whether specific candidate genes are implicated in these phenotypes in the multifactorial context of DS. Here we report that transgenic mice (TgDyrk1A) with overdosage of Dyrk1A, a DS candidate gene, show important alterations in adult neurogenesis including reduced cell proliferation rate, altered cell cycle progression and reduced cell cycle exit leading to premature migration, differentiation and reduced survival of newly born cells. In addition, less proportion of newborn hippocampal TgDyrk1A neurons are activated upon learning, suggesting reduced integration in learning circuits. Some of these alterations were DYRK1A kinase-dependent since we could rescue those using a DYRK1A inhibitor, epigallocatechin-3-gallate. Environmental enrichment also normalized DYRK1A kinase overdosage in the hippocampus, and rescued adult neurogenesis alterations in TgDyrk1A mice. We conclude that Dyrk1A is a good candidate to explain neuronal plasticity deficits in DS and that normalizing the excess of DYRK1A kinase activity either pharmacologically or using environmental stimulation can correct adult neurogenesis defects in DS. PMID:23969234

  17. The protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development.

    PubMed

    Guo, Li; Lee, Audrey A; Rizvi, Tilat A; Ratner, Nancy; Kirschner, Lawrence S

    2013-11-13

    Signaling through cAMP has been implicated in Schwann cell (SC) proliferation and myelination, but the signaling pathway components downstream of cAMP required for SC function remain unknown. Protein kinase A (PKA) is a potential downstream effector of cAMP. Here, we induced loss of Prkar1a, the gene encoding the type 1A regulatory subunit of PKA, in SC to study its role in nerve development; loss of Prkar1a is predicted to elevate PKA activity. Conditional Prkar1a knock-out in mouse SC (Prkar1a-SCKO) resulted in a dramatic and persistent axonal sorting defect, and unexpectedly decreased SC proliferation in Prkar1a-SCKO nerves in vivo. Effects were cell autonomous as they were recapitulated in vitro in Prkar1a-SCKO SC, which showed elevated PKA activity. In the few SCs sorted into 1:1 relationships with axons in vivo, SC myelination was premature in Prkar1a-SCKO nerves, correlating with global increase in the cAMP-regulated transcription factor Oct-6 and expression of myelin basic protein. These data reveal a previously unknown role of PKA in axon sorting, an unexpected inhibitory role of PKA on SC cell proliferation in vivo and define the importance of Prkar1a in peripheral nerve development. PMID:24227708

  18. Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10

    PubMed Central

    Ramírez, Jacqueline; Mirkov, Snezana; House, Larry K.

    2015-01-01

    OTS167 is a potent maternal embryonic leucine zipper kinase inhibitor undergoing clinical testing as antineoplastic agent. We aimed to identify the UDP-glucuronosyltransferases (UGTs) involved in OTS167 metabolism, study the relationship between UGT genetic polymorphisms and hepatic OTS167 glucuronidation, and investigate the inhibitory potential of OTS167 on UGTs. Formation of a single OTS167-glucuronide (OTS167-G) was observed in pooled human liver (HLM) (Km = 3.4 ± 0.2 µM), intestinal microsomes (HIM) (Km = 1.7 ± 0.1 µM), and UGTs. UGT1A1 (64 µl/min/mg) and UGT1A8 (72 µl/min/mg) exhibited the highest intrinsic clearances (CLint) for OTS167, followed by UGT1A3 (51 µl/min/mg) and UGT1A10 (47 µl/min/mg); UGT1A9 was a minor contributor. OTS167 glucuronidation in HLM was highly correlated with thyroxine glucuronidation (r = 0.91, P < 0.0001), SN-38 glucuronidation (r = 0.79, P < 0.0001), and UGT1A1 mRNA (r = 0.72, P < 0.0001). Nilotinib (UGT1A1 inhibitor) and emodin (UGT1A8 and UGT1A10 inhibitor) exhibited the highest inhibitory effects on OTS167-G formation in HLM (68%) and HIM (47%). We hypothesize that OTS167-G is an N-glucuronide according to mass spectrometry. A significant association was found between rs6706232 and reduced OTS167-G formation (P = 0.03). No or weak UGT inhibition (range: 0–21%) was observed using clinically relevant OTS167 concentrations (0.4–2 µM). We conclude that UGT1A1 and UGT1A3 are the main UGTs responsible for hepatic formation of OTS167-G. Intestinal UGT1A1, UGT1A8, and UGT1A10 may contribute to first-pass OTS167 metabolism after oral administration. PMID:25870101

  19. Using Unique Identifiers to Promote Data Sharing between Part C and Part B. inForum

    ERIC Educational Resources Information Center

    Keller-Allen, Chandra

    2009-01-01

    Obligations of state education agencies (SEAs) and Part C lead agencies set forth by the Individuals with Disabilities Education Act (IDEA) pertaining to early childhood transition from Part C to Part B of IDEA are described in several regulatory and guidance documents including Part C draft regulations (34 CFR Part 303), Part B regulations (34…

  20. 37 CFR 41.11 - Ex Parte communications in inter partes proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... inter partes proceedings. 41.11 Section 41.11 Patents, Trademarks, and Copyrights UNITED STATES PATENT... INTERFERENCES General Provisions § 41.11 Ex Parte communications in inter partes proceedings. An ex parte communication about an inter partes reexamination (subpart C of this part) or about a contested case (subparts...

  1. Molecular dynamics studies of U1A-RNA complexes.

    PubMed Central

    Reyes, C M; Kollman, P A

    1999-01-01

    The U1A protein binds to a hairpin RNA and an internal-loop RNA with picomolar affinities. To probe the molecular basis of U1A binding, we performed state-of-the-art nanosecond molecular dynamics simulations on both complexes. The good agreement with experimental structures supports the protocols used in the simulations. We compare the dynamics, hydrogen-bonding occupancies, and interfacial flexibility of both complexes and also describe a rigid-body motion in the U1A-internal loop complex that is not observed in the U1A-hairpin simulation. We relate these observations to experimental mutational studies and highlight their significance in U1A binding affinity and specificity. PMID:10024175

  2. JPL preferred parts list: Reliable electronic components

    NASA Technical Reports Server (NTRS)

    Covey, R. E.; Scott, W. R.; Hess, L. M.; Steffy, T. G.; Stott, F. R.

    1982-01-01

    The JPL Preferred Parts List was prepared to provide a basis for selection of electronic parts for JPL spacecraft programs. Supporting tests for the listed parts were designed to comply with specific spacecraft environmental requirements. The list tabulates the electronic, magnetic, and electromechanical parts applicable to all JPL electronic equipment wherein reliability is a major concern. The parts listed are revelant to equipment supplied by subcontractors as well as fabricated at the laboratory.

  3. Management of a coordinated parts program

    NASA Technical Reports Server (NTRS)

    Krishnan, G. S.

    1997-01-01

    The organization of the management of a parts program is discussed. The organizational structure faced by the parts manager and the advantages and disadvantages of managing a coordinated parts program are analyzed. The reliable operation of an instrument is the key to the success of the mission, together with the management of the parts program. The analysis led to the conclusion that the setting up of the decision support model will aid the parts manager in the decision making and the process control.

  4. Novel SCN1A variants in Dravet syndrome and evaluating a wide approach of patient selection.

    PubMed

    Surovy, Milan; Soltysova, Andrea; Kolnikova, Miriam; Sykora, Pavol; Ilencikova, Denisa; Ficek, Andrej; Radvanszky, Jan; Kadasi, Ludevit

    2016-07-01

    Voltage-gated sodium channels are essential for generation and propagation of the action potential mainly in nerve and muscle cells. Causative variants in SCN1A gene which codes the main, pore-forming subunit of the channel expressed in central nervous system are associated predominantly with Dravet syndrome (DS), as well as with generalized epilepsy with febrile seizures plus (GEFS+) making it one of the most significant epilepsy gene. Our goal was to determine whether SCN1A screening is relevant in patients with a broad range of epileptic syndromes. 52 patients diagnosed with DS, generalized epilepsy with GEFS+ or similar types of epileptic syndromes were included. Sequencing of the protein coding parts of the gene complemented with MLPA analysis was carried out. One already described nonsense variant, four novel protein truncating variants and a deletion encompassing the whole SCN1A gene were revealed, all in heterozygous state. All identified variants were found in DS patients with 85.7% sensitivity, thus supporting the role of profound SCN1A gene variants in etiology of DS phenotype. No causative variants were identified in any of non-DS epileptic patients in our cohort, suggesting a minor, but not irrelevant role for SCN1A in patients with other types of childhood epilepsy. PMID:27045673

  5. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference

    NASA Astrophysics Data System (ADS)

    Yi, Tingfang; Arthanari, Haribabu; Akabayov, Barak; Song, Huaidong; Papadopoulos, Evangelos; Qi, Hank H.; Jedrychowski, Mark; Güttler, Thomas; Guo, Cuicui; Luna, Rafael E.; Gygi, Steven P.; Huang, Stephen A.; Wagner, Gerhard

    2015-05-01

    MicroRNA (miRNA) biogenesis and miRNA-guided RNA interference (RNAi) are essential for gene expression in eukaryotes. Here we report that translation initiation factor eIF1A directly interacts with Ago2 and promotes Ago2 activities in RNAi and miR-451 biogenesis. Biochemical and NMR analyses demonstrate that eIF1A binds to the MID domain of Ago2 and this interaction does not impair translation initiation. Alanine mutation of the Ago2-facing Lys56 in eIF1A impairs RNAi activities in human cells and zebrafish. The eIF1A-Ago2 assembly facilitates Dicer-independent biogenesis of miR-451, which mediates erythrocyte maturation. Human eIF1A (heIF1A), but not heIF1A(K56A), rescues the erythrocyte maturation delay in eif1axb knockdown zebrafish. Consistently, miR-451 partly compensates erythrocyte maturation defects in zebrafish with eif1axb knockdown and eIF1A(K56A) expression, supporting a role of eIF1A in miRNA-451 biogenesis in this model. Our results suggest that eIF1A is a novel component of the Ago2-centred RNA-induced silencing complexes (RISCs) and augments Ago2-dependent RNAi and miRNA biogenesis.

  6. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference

    PubMed Central

    Yi, Tingfang; Arthanari, Haribabu; Akabayov, Barak; Song, Huaidong; Papadopoulos, Evangelos; Qi, Hank H.; Jedrychowski, Mark; Güttler, Thomas; Guo, Cuicui; Luna, Rafael E.; Gygi, Steven P.; Huang, Stephen A.; Wagner, Gerhard

    2015-01-01

    MicroRNA (miRNA) biogenesis and miRNA-guided RNA interference (RNAi) are essential for gene expression in eukaryotes. Here we report that translation initiation factor eIF1A directly interacts with Ago2 and promotes Ago2 activities in RNAi and miR-451 biogenesis. Biochemical and NMR analyses demonstrate that eIF1A binds to the MID-domain of Ago2 and this interaction does not impair translation initiation. Alanine mutation of the Ago2-facing Lys56 in eIF1A impairs RNAi activities in human cells and zebrafish. The eIF1A-Ago2 assembly facilitates Dicer-independent biogenesis of miR-451, which mediates erythrocyte maturation. Human eIF1A (heIF1A), but not heIF1A(K56A), rescues the erythrocyte maturation delay in eif1axb knockdown zebrafish. Consistently, miR-451 partly compensates erythrocyte maturation defects in zebrafish with eif1axb knockdown and eIF1A(K56A) expression, supporting a role of eIF1A in miRNA-451 biogenesis in this model. Our results suggest that eIF1A is a novel component of the Ago2-centered RNA induced silencing complexes (RISCs) and augments Ago2-dependent RNAi and miRNA biogenesis. PMID:26018492

  7. Alveolar rhabdomyosarcoma-associated proteins PAX3/FOXO1A and PAX7/FOXO1A suppress the transcriptional activity of MyoD-target genes in muscle stem cells.

    PubMed

    Calhabeu, F; Hayashi, S; Morgan, J E; Relaix, F; Zammit, P S

    2013-01-31

    Rhabdomyosarcoma (RMS) is the commonest soft-tissue sarcoma in childhood and is characterized by expression of myogenic proteins, including the transcription factors MyoD and myogenin. There are two main subgroups, embryonal RMS and alveolar RMS (ARMS). Most ARMS are associated with chromosomal translocations that have breakpoints in introns of either PAX3 or PAX7, and FOXO1A. These translocations create chimeric transcription factors termed PAX3/FOXO1A and PAX7/FOXO1A respectively. Upon ectopic PAX3/FOXO1A expression, together with other genetic manipulation in mice, both differentiating myoblasts and satellite cells (the resident stem cells of postnatal muscle) can give rise to tumours with ARMS characteristics. As PAX3 and PAX7 are part of transcriptional networks that regulate muscle stem cell function in utero and during early postnatal life, PAX3/FOXO1A and PAX7/FOXO1A may subvert normal PAX3 and PAX7 functions. Here we examined how PAX3/FOXO1A and PAX7/FOXO1A affect myogenesis in satellite cells. PAX3/FOXO1A or PAX7/FOXO1A inhibited myogenin expression and prevented terminal differentiation in murine satellite cells: the same effect as dominant-negative (DN) Pax3 or Pax7 constructs. The transcription of MyoD-target genes myogenin and muscle creatine kinase were suppressed by PAX3/FOXO1A or PAX7/FOXO1A in C2C12 myogenic cells again as seen with Pax3/7DN. PAX3/FOXO1A or PAX7/FOXO1A did not inhibit the transcriptional activity of MyoD by perturbing MyoD expression, localization, phosphorylation or interaction with E-proteins. Chromatin immunoprecipitation on the myogenin promoter showed that PAX3/FOXO1A or PAX7/FOXO1A did not prevent MyoD from binding. However, PAX3/FOXO1A or PAX7/FOXO1A reduced occupation of the myogenin promoter by RNA polymerase II and decreased acetylation of histone H4, but did not directly bind to the myogenin promoter. Together, these observations reveal that PAX3/FOXO1A and PAX7/FOXO1A act to prevent myogenic differentiation via

  8. 12 CFR 585.50 - What adjudications and offenses are not covered by this part?

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and offenses are not covered by this part? (a) Youthful offender or juvenile delinquent. This part does not cover any adjudication by a court against a person as: (1) A youthful offender under any youthful offender law; or (2) A juvenile delinquent by a court with jurisdiction over minors as defined...

  9. Effects of Phenobarbital on Expression of UDP-Glucuronosyltransferase 1a6 and 1a7 in Rat Brain.

    PubMed

    Sakakibara, Yukiko; Katoh, Miki; Kondo, Yuya; Nadai, Masayuki

    2016-03-01

    UDP-glucuronosyltransferase (UGT), a phase II drug-metabolizing enzyme, is expressed in the brain and can catalyze glucuronidation of endogenous and exogenous substrates in the brain. Thus, changes in UGT1A expression could affect homeostasis and drug efficacy. Phenobarbital (PB), a typical inducer of drug-metabolizing enzymes, has been reported to induce oxidative stress and epigenetic changes, which could alter UGT expression in the brain. Here, we aimed to clarify the effects of PB on Ugt1a6 and Ugt1a7 gene expression in rat brains. Sprague-Dawley rats were treated intraperitoneally with PB (80 mg/kg), once daily for 7 days. Ugt1a6 and Ugt1a7 mRNA expression levels were increased in the striatum and thalamus (Ugt1a6, 3.0- and 2.9-fold, respectively; Ugt1a7, 2.6- and 2.6-fold, respectively). Acetaminophen glucuronidation was also increased in the medulla oblongata and thalamus by 1.8- and 1.2-fold, respectively. The induction rates within different brain regions were correlated with Ugt1a6 and Ugt1a7 mRNA expression, and the degree of induction also correlated with that of NF-E2-related factor-2 mRNA. Measurement of oxidative stress markers suggested that PB induced oxidative stress in brain regions in which Ugt1a6 and Ugt1a7 mRNAs were increased. Moreover, histone modifications were altered by PB treatment, resulting in increased histone H3 lysine 4 trimethylation in the striatum and thalamus and decreased histone H3 lysine 9 trimethylation in the thalamus. These results suggested that oxidative stress and histone modifications may promote transcriptional activation of Ugt1a6 and Ugt1a7 genes. In summary, Ugt1a6 and Ugt1a7 mRNA levels were increased by PB treatment, which may alter pharmacokinetics in the brain. PMID:26684499

  10. Commercial Parts Technology Qualification Processes

    NASA Technical Reports Server (NTRS)

    Cooper, Mark S.

    2013-01-01

    Many high-reliability systems, including space systems, use selected commercial parts (including Plastic Encapsulated Microelectronics or PEMs) for unique functionality, small size, low weight, high mechanical shock resistance, and other factors. Predominantly this usage is subjected to certain 100% tests (typically called screens) and certain destructive tests usually (but not always) performed on the flight lot (typically called qualification tests). Frequently used approaches include those documented in EEE-INST-002 and JPL DocID62212 (which are sometimes modified by the particular aerospace space systems manufacturer). In this study, approaches from these documents and several space systems manufacturers are compared to approaches from a launch systems manufacturer (SpaceX), an implantable medical electronics manufacturer (Medtronics), and a high-reliability transport system process (automotive systems). In the conclusions section, these processes are outlined for all of these cases and presented in tabular form. Then some simple comparisons are made. In this introduction section, the PEM technology qualification process is described, as documented in EEE-INST-002 (written by the Goddard Space Flight Center, GSFC), as well as the somewhat modified approach employed at the Jet Propulsion Laboratory (JPL). Approaches used at several major NASA contractors are also described

  11. Beluga whale liver microsomal cytochrome P4501A (CYP1A) enzymes

    SciTech Connect

    Bullock, P.L.; Addison, R.; Lockhart, L.; Metner, D.

    1995-12-31

    Beluga whale (Delphinapterus leucas) liver from the Canadian arctic was analyzed for the presence of CYP1A enzymes, as part of current studies on biomarkers for environmental contamination. CYP1A1-associated 7-ethoxyresorufin O-dealkylase activity (EROD) varied 13 fold among sixteen male whale liver microsomal samples and 31 fold among five females. Similarly, the rate of 7-methoxyresorufin O-dealkylation (MROD) varied 7 fold and 3 fold in microsomal samples from males and females, respectively. Furthermore, 7-pentoxyresorufin O-dealkylase activity (PROD) varied 10 fold in both sexes. None of these enzyme activities were sexually differentiated, and EROD and MROD were inhibited by {alpha}-naphthoflavone. There was very good correlation between EROD and MROD (r{sup 2} = .894), EROD and PROD (r{sup 2} = .909), but MROD and PROD were not as well correlated (r{sup 2} = 785). On Western immunoblots, a single band was recognized in Beluga whale liver microsomes by a polygonal antibody raised against an oligopeptide related to trout CYP1A1. This antibody also recognized purified rat CYP1A1 (56 kDa) and stained only one band (56 kDa) in liver microsomes isolated from male rats treated with {beta}-naphthoflavone. The interindividual variation in EROD paralleled differences in the amount of whale liver microsomal protein that cross-reacted with the anti-peptide antibody. The results suggest that Beluga whale liver contains at least one CYP1A enzyme which catalyzes the 0-dealkylation of 7-ethoxy, 7-methoxy and 7-pentoxyresorufin and has a molecular weight less than that of rat CYP1A1, but similar to rat CYP1A2 (52 kDa).

  12. Epigeneitc silencing of ribosomal RNA genes by Mybbp1a

    PubMed Central

    2012-01-01

    Background Transcription of the ribosomal RNA gene repeats by Pol I occurs in the nucleolus and is a fundamental step in ribosome biogenesis and protein translation. Due to tight coordination between ribosome biogenesis and cell proliferation, transcription of rRNA and stable maintenance of rDNA clusters are thought to be under intricate control by intercalated mechanisms, particularly at the epigenetic level. Methods and Results Here we identify the nucleolar protein Myb-binding protein 1a (Mybbp1a) as a novel negative regulator of rRNA expression. Suppression of rDNA transcription by Mybbp1a was linked to promoter regulation as illustrated by its binding to the chromatin around the hypermethylated, inactive rDNA gene promoters. Our data further showed that downregulation of Mybbp1a abrogated the local DNA methylation levels and histone marks associated with gene silencing, and altered the promoter occupancy of various factors such UBF and HDACs, consequently leading to elevated rRNA expression. Mechanistically, we propose that Mybbp1a maintains rDNA repeats in a silenced state while in association with the negative epigenetic modifiers HDAC1/2. Conclusions Results from our present work reveal a previously unrecognized co-repressor role of Mybbp1a in rRNA expression. They are further consistent with the scenario that Mybbp1a is an integral constituent of the rDNA epigenetic regulation that underlies the balanced state of rDNA clusters. PMID:22686419

  13. Rab1a regulates sorting of early endocytic vesicles

    PubMed Central

    Mukhopadhyay, Aparna; Quiroz, Jose A.

    2014-01-01

    We previously reported that Rab1a is associated with asialoorosomucoid (ASOR)-containing early endocytic vesicles, where it is required for their microtubule-based motility. In Rab1a knockdown (KD) cell lines, ASOR failed to segregate from its receptor and, consequently, did not reach lysosomes for degradation, indicating a defect in early endosome sorting. Although Rab1 is required for Golgi/endoplasmic reticulum trafficking, this process was unaffected, likely due to retained expression of Rab1b in these cells. The present study shows that Rab1a has a more general role in endocytic vesicle processing that extends to EGF and transferrin (Tfn) trafficking. Compared with results in control Huh7 cells, EGF accumulated in aggregates within Rab1a KD cells, failing to reach lysosomal compartments. Tfn, a prototypical example of recycling cargo, accumulated in a Rab11-mediated slow-recycling compartment in Rab1a KD cells, in contrast to control cells, which sort Tfn into a fast-recycling Rab4 compartment. These data indicate that Rab1a is an important regulator of early endosome sorting for multiple cargo species. The effectors and accessory proteins recruited by Rab1a to early endocytic vesicles include the minus-end-directed kinesin motor KifC1, while others remain to be discovered. PMID:24407591

  14. BioCreAtIvE Task 1A: gene mention finding evaluation

    PubMed Central

    Yeh, Alexander; Morgan, Alexander; Colosimo, Marc; Hirschman, Lynette

    2005-01-01

    Background The biological research literature is a major repository of knowledge. As the amount of literature increases, it will get harder to find the information of interest on a particular topic. There has been an increasing amount of work on text mining this literature, but comparing this work is hard because of a lack of standards for making comparisons. To address this, we worked with colleagues at the Protein Design Group, CNB-CSIC, Madrid to develop BioCreAtIvE (Critical Assessment for Information Extraction in Biology), an open common evaluation of systems on a number of biological text mining tasks. We report here on task 1A, which deals with finding mentions of genes and related entities in text. "Finding mentions" is a basic task, which can be used as a building block for other text mining tasks. The task makes use of data and evaluation software provided by the (US) National Center for Biotechnology Information (NCBI). Results 15 teams took part in task 1A. A number of teams achieved scores over 80% F-measure (balanced precision and recall). The teams that tried to use their task 1A systems to help on other BioCreAtIvE tasks reported mixed results. Conclusion The 80% plus F-measure results are good, but still somewhat lag the best scores achieved in some other domains such as newswire, due in part to the complexity and length of gene names, compared to person or organization names in newswire. PMID:15960832

  15. Impact of Dyrk1A level on alcohol metabolism.

    PubMed

    Renon, Marjorie; Legrand, Béatrice; Blanc, Etienne; Daubigney, Fabrice; Bokobza, Cindy; Mortreux, Marie; Paul, Jean-Louis; Delabar, Jean-Maurice; Rouach, Hélène; Andreau, Karine; Janel, Nathalie

    2016-09-01

    Alcoholic liver diseases arise from complex phenotypes involving many genetic factors. It is quite common to find hyperhomocysteinemia in chronic alcoholic liver diseases, mainly due to deregulation of hepatic homocysteine metabolism. Dyrk1A, involved in homocysteine metabolism at different crossroads, is decreased in liver of hyperhomocysteinemic mice. Here, we hypothesized that Dyrk1A contributes to alcohol-induced hepatic impairment in mice. Control, hyperhomocysteinemic and mice overexpressing Dyrk1A were fed using a Lieber-DeCarli liquid diet with or without ethanol (5% v/v ethanol) for one month, and liver histological examination and liver biochemical function tests were performed. Plasma alanine aminotransferase and homocysteine levels were significantly decreased in mice overexpressing Dyrk1A compared to control mice with or without alcohol administration. On the contrary, the mean plasma alanine aminotransferase and homocysteine levels were significantly higher in hyperhomocysteinemic mice than that of control mice after alcohol administration. Paraoxonase 1 and CYP2E1, two phase I xenobiotic metabolizing enzymes, were found increased in the three groups of mice after alcohol administration. However, NQO1, a phase II enzyme, was only found increased in hyperhomocysteinemic mice after alcohol exposure, suggesting a greater effect of alcohol in liver of hyperhomocysteinemic mice. We observed positive correlations between hepatic alcohol dehydrogenase activity, Dyrk1A and ADH4 protein levels. Importantly, a deleterious effect of alcohol consumption on hepatic Dyrk1A protein level was found. Our study reveals on the one hand a role of Dyrk1A in ethanol metabolism and on the other hand a deleterious effect of alcohol administration on hepatic Dyrk1A level. PMID:27216978

  16. Range Imaging without Moving Parts

    NASA Technical Reports Server (NTRS)

    Blair, J. Bryan; Scott, V. Stanley, III; Ramos-Izquierdo, Luis

    2008-01-01

    Range-imaging instruments of a type now under development are intended to generate the equivalent of three-dimensional images from measurements of the round-trip times of flight of laser pulses along known directions. These instruments could also provide information on characteristics of targets, including roughnesses and reflectivities of surfaces and optical densities of such semi-solid objects as trees and clouds. Unlike in prior range-imaging instruments based on times of flight along known directions, there would be no moving parts; aiming of the laser beams along the known directions would not be accomplished by mechanical scanning of mirrors, prisms, or other optical components. Instead, aiming would be accomplished by using solid-state devices to switch input and output beams along different fiber-optic paths. Because of the lack of moving parts, these instruments could be extraordinarily reliable, rugged, and long-lasting. An instrument of this type would include an optical transmitter that would send out a laser pulse along a chosen direction to a target. An optical receiver coaligned with the transmitter would measure the temporally varying intensity of laser light reflected from the target to determine the distance and surface characteristics of the target. The transmitter would be a combination of devices for generating precise directional laser illumination. It would include a pulsed laser, the output of which would be coupled into a fiber-optic cable with a fan-out and solid-state optical switches that would enable switching of the laser beam onto one or more optical fibers terminated at known locations in an array on a face at the focal plane of a telescope. The array would be imaged by the telescope onto the target space. The receiver optical system could share the aforementioned telescope with the transmitter or could include a separate telescope aimed in the same direction as that of the transmitting telescope. In either case, light reflected

  17. [First part: the intestinal microbiota].

    PubMed

    Capurso, Lucio

    2016-06-01

    The human gastrointestinal tract contains a large number of commensal (non pathogenic) and pathogenic microbial species that have co-evolved with the human genome and differ in composition and function based on their location, as well as age, sex, race/ethnicity, and diet of their host and we can in fact consider the human body as a mix of human and bacterial cells. It is now evident that the large intestine is much more than an organ for waste material and absorption of water, salts and drugs, and indeed has a very important impact on human health, for a major part related to the specific composition of the complex microbial community in the colon. In man, the large gut receives material from the ileum which has already been digested and the contents are then mixed and retained for 6-12 hours in the caecum and right colon. Thus, the large intestine is an open system, with nutrients flowing in the caecum, and bacteria, their metabolic products, and undigested foodstuffs being excreted as faeces. The anaerobic brakdown of carbohydrate and protein by bacteria is known conventionally as fermentation. In man the major end products are the short-chain fatty acids (SCFA) acetate, propionate, butirate, the gases H2 and CO2, ammonia, amines, phenols and energy, which the bacteria use for growth and the maintenance of cellular function. The microbiota is also an important factor in the development of the immune response. The interaction between the gastrointestinal tract and resident microbiota is well balanced in healthy individuals, but its breakdown can lead to intestinal and extraintestinal disease. PMID:27362717

  18. 49 CFR Figure 1a to Subpart B of... - Example of Location of Rescue Access Windows-§ 238.114

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Example of Location of Rescue Access Windows-§ 238.114 1A Figure 1A to Subpart B of Part 238 Transportation Other Regulations Relating to... B of Part 238—Example of Location of Rescue Access Windows—§ 238.114 ER01FE08.002...

  19. Two part mine roof support unit

    SciTech Connect

    Becker, K.; Dunkel, G.; Elsner, B.

    1983-08-30

    A mine roof support unit is constituted by two detachably connected parts. Each of the parts has a floor girder which supports a roof bar by means of a hydraulic prop. The roof support unit is intended for use at the lower end of an inclined longwall working which meets its access gallery at an angle other than 90/sup 0/. The detachability of the two parts enables one of these parts to be removed from the working as its face is advanced. The removed part can then be transported to the other end of working. Each of the parts is provided with means for detachably connecting an advance mechanism.

  20. 34 CFR Appendix E to Part 300 - Index for IDEA-Part B Regulations (34 CFR Part 300)

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Index for IDEA-Part B Regulations (34 CFR Part 300) E... B Regulations (34 CFR Part 300) ACCESS TO • Access rights (Parents) 300.613. • Assistive technology... “Limited English proficient”) LEUKEMIA (Other health impairment) 300.8(c)(9)(i). LIMITED ENGLISH...

  1. 34 CFR Appendix E to Part 300 - Index for IDEA-Part B Regulations (34 CFR Part 300)

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Index for IDEA-Part B Regulations (34 CFR Part 300) E... B Regulations (34 CFR Part 300) ACCESS TO • Access rights (Parents) 300.613. • Assistive technology... “Limited English proficient”) LEUKEMIA (Other health impairment) 300.8(c)(9)(i). LIMITED ENGLISH...

  2. 34 CFR Appendix E to Part 300 - Index for IDEA-Part B Regulations (34 CFR Part 300)

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Index for IDEA-Part B Regulations (34 CFR Part 300) E... B Regulations (34 CFR Part 300) ACCESS TO • Access rights (Parents) 300.613. • Assistive technology... 300.8(c)(6). • Multiple disabilities 300.8(c)(7). • Native language 300.29(a). • Occupational...

  3. 34 CFR Appendix E to Part 300 - Index for IDEA-Part B Regulations (34 CFR Part 300)

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Index for IDEA-Part B Regulations (34 CFR Part 300) E... B Regulations (34 CFR Part 300) ACCESS TO • Access rights (Parents) 300.613. • Assistive technology...). • Protections for children not determined eligible 300.534. • Secretaries of the Interior and Health and...

  4. 34 CFR Appendix E to Part 300 - Index for IDEA-Part B Regulations (34 CFR Part 300)

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Index for IDEA-Part B Regulations (34 CFR Part 300) E Appendix E to Part 300 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN...

  5. Derivation of Formulations 1 and 1A of Farassat

    NASA Technical Reports Server (NTRS)

    Farassat, F.

    2007-01-01

    Formulations 1 and 1A are the solutions of the Ffowcs Williams-Hawkings (FW-H) equation with surface sources only when the surface moves at subsonic speed. Both formulations have been successfully used for helicopter rotor and propeller noise prediction for many years although we now recommend using Formulation 1A for this purpose. Formulation 1 has an observer time derivative that is taken numerically, and thus, increasing execution time on a computer and reducing the accuracy of the results. After some discussion of the Green's function of the wave equation, we derive Formulation 1 which is the basis of deriving Formulation 1A. We will then show how to take this observer time derivative analytically to get Formulation 1A. We give here the most detailed derivation of these formulations. Once you see the whole derivation, you will ask yourself why you did not do it yourself!

  6. 1. A BRICK AND CONCRETE FAN HOUSING ADJACENT TO ONE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. A BRICK AND CONCRETE FAN HOUSING ADJACENT TO ONE OF THE ADIT OPENINGS (VIEW TO THE NORTH). - Foster Gulch Mine, Fan Housing, Bear Creek 1 mile Southwest of Town of Bear Creek, Red Lodge, Carbon County, MT

  7. Distinct neurological disorders with ATP1A3 mutations

    PubMed Central

    Heinzen, Erin L.; Arzimanoglou, Alexis; Brashear, Allison; Clapcote, Steven J.; Gurrieri, Fiorella; Goldstein, David B.; Jóhannesson, Sigurður H.; Mikati, Mohamad A.; Neville, Brian; Nicole, Sophie; Ozelius, Laurie J.; Poulsen, Hanne; Schyns, Tsveta; Sweadner, Kathleen J.; van den Maagdenberg, Arn; Vilsen, Bente

    2014-01-01

    Genetic research has shown that mutations that modify the protein-coding sequence of ATP1A3, the gene encoding the α3 subunit of Na+/K+-ATPase, cause both rapid-onset dystonia parkinsonism and alternating hemiplegia of childhood. These discoveries link two clinically distinct neurological diseases to the same gene, however, ATP1A3 mutations are, with one exception, disease-specific. Although the exact mechanism of how these mutations lead to disease is still unknown, much knowledge has been gained about functional consequences of ATP1A3 mutations using a range of in vitro and animal model systems, and the role of Na+/K+-ATPases in the brain. Researchers and clinicians are attempting to further characterise neurological manifestations associated with mutations in ATP1A3, and to build on the existing molecular knowledge to understand how specific mutations can lead to different diseases. PMID:24739246

  8. Distinct neurological disorders with ATP1A3 mutations.

    PubMed

    Heinzen, Erin L; Arzimanoglou, Alexis; Brashear, Allison; Clapcote, Steven J; Gurrieri, Fiorella; Goldstein, David B; Jóhannesson, Sigurður H; Mikati, Mohamad A; Neville, Brian; Nicole, Sophie; Ozelius, Laurie J; Poulsen, Hanne; Schyns, Tsveta; Sweadner, Kathleen J; van den Maagdenberg, Arn; Vilsen, Bente

    2014-05-01

    Genetic research has shown that mutations that modify the protein-coding sequence of ATP1A3, the gene encoding the α3 subunit of Na(+)/K(+)-ATPase, cause both rapid-onset dystonia parkinsonism and alternating hemiplegia of childhood. These discoveries link two clinically distinct neurological diseases to the same gene, however, ATP1A3 mutations are, with one exception, disease-specific. Although the exact mechanism of how these mutations lead to disease is still unknown, much knowledge has been gained about functional consequences of ATP1A3 mutations using a range of in-vitro and animal model systems, and the role of Na(+)/K(+)-ATPases in the brain. Researchers and clinicians are attempting to further characterise neurological manifestations associated with mutations in ATP1A3, and to build on the existing molecular knowledge to understand how specific mutations can lead to different diseases. PMID:24739246

  9. 1. A LONG VIEW, LOOKING NORTH FROM THE WEST BANK ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. A LONG VIEW, LOOKING NORTH FROM THE WEST BANK OF LITTLE WALNUT CREEK TOWARD THE SOUTH (DOWNSTREAM) SIDE OF THE BRIDGE - Putnam County Bridge No. 111, Spanning Little Walnut Creek on County Road 50, Greencastle, Putnam County, IN

  10. KIF 1A: A Processive Monomeric Brownian Kinesin Motor

    NASA Astrophysics Data System (ADS)

    Hirokawa, Nobutaka

    2000-03-01

    We have identified a new monomeric kinesin superfamily motor, KIF 1A, which moves processively on microtubule towards its plus end by the biased Brownian movement. In this symposium I will present our data on the motility assay of a single monomeric KIF 1A molecule, biochemical characterization, and cryo-electron microscopical analyses of KIF 1A-microtutubule complex. The key finding is the nucleotide-dependent binding between the lysine-rich, highly positively-charged loop 12 of the KIF 1A motor domain(K-loop) and the glutamate-rich highly negatively-charged C-terminal region of tubulin (E-hook). This binding did not contribute in the "strong binding state", but only in the "weak binding state" and was demonstrated to be essential for the single-headed processivity by functioning as the anchor for the one-dimensional simple Brownian movement in the weak binding state.

  11. Recurrent PRKAR1A mutation in acrodysostosis with hormone resistance.

    PubMed

    Linglart, Agnès; Menguy, Christine; Couvineau, Alain; Auzan, Colette; Gunes, Yasemin; Cancel, Mathilde; Motte, Emmanuelle; Pinto, Graziella; Chanson, Philippe; Bougnères, Pierre; Clauser, Eric; Silve, Caroline

    2011-06-01

    The skeletal dysplasia characteristic of acrodysostosis resembles the Albright's hereditary osteodystrophy seen in patients with pseudohypoparathyroidism type 1a, but defects in the α-stimulatory subunit of the G-protein (GNAS), the cause of pseudohypoparathyroidism type 1a, are not present in patients with acrodysostosis. We report a germ-line mutation in the gene encoding PRKAR1A, the cyclic AMP (cAMP)-dependent regulatory subunit of protein kinase A, in three unrelated patients with acrodysostosis and resistance to multiple hormones. The mutated subunit impairs the protein kinase A response to stimulation by cAMP; this explains our patients' hormone resistance and the similarities of their skeletal abnormalities with those observed in patients with pseudohypoparathyroidism type 1a. PMID:21651393

  12. 47 CFR 80.1091 - Ship radio equipment-Sea areas A1, A2, and A3.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies of these standards can be inspected at the Federal... 47 Telecommunication 5 2010-10-01 2010-10-01 false Ship radio equipment-Sea areas A1, A2, and A3... SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Global Maritime Distress and Safety System...

  13. 47 CFR 80.1091 - Ship radio equipment-Sea areas A1, A2, and A3.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... accordance with 5 U.S.C. 552(a) and 1 CFR part 51. Copies of these standards can be inspected at the Federal... 47 Telecommunication 5 2011-10-01 2011-10-01 false Ship radio equipment-Sea areas A1, A2, and A3... SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Global Maritime Distress and Safety System...

  14. Paresev 1-A on lakebed with tow plane

    NASA Technical Reports Server (NTRS)

    1962-01-01

    The Paresev 1-A (Paraglider Research Vehicle) and the tow airplane, 450-hp Stearman sport Biplane, sitting on Rogers dry lakebed, Edwards, California. The control system in the Paresev 1-A had a more conventional control stick position and was cable-operated; the main landing gear used shocks and bungees with the 150-square-foot wing membrane being made of 6-ounce unsealed Dacron.

  15. Paresev 1-A on Lakebed with Tow Plane

    NASA Technical Reports Server (NTRS)

    1962-01-01

    The Paresev 1-A (Paraglider Research Vehicle) and the tow airplane, 450-hp Stearman Sport Biplane sitting on Rogers dry lakebed, Edwards, California. The control system in the Paresev 1-A had a more conventional control stick position and was cable-operated. The main landing gear used shocks and bungees with the 150-square-foot wing membrane being made of 6-ounce unsealed Dacron.

  16. Paresev 1-A and tow plane with crew and pilot

    NASA Technical Reports Server (NTRS)

    1962-01-01

    With the the Paresev 1-A and the 450-hp Stearman sport Biplane as a backdrop the Pilot and crew pose for this picture in 1962. Starting at left: On the motorcycle is Walter Whiteside, in the Paresev 1-A is test pilot Milton Thompson, Frank Fedor, Richard Klein, Victor Horton, Tom Kelly, Jr., Fred Harris, owner of the Stearman, John Orahood, and Gary Layton.

  17. [Antidepressants, stressors and the serotonin 1A receptor].

    PubMed

    Kirilly, Eszter; Gonda, Xénia; Bagdy, György

    2015-06-01

    5-HT(1A) receptor is a receptor of surprises. Buspirone, an anxiolytic drug with a then yet unidentified mechanism of action had been marketed for years when it was discovered that it is a 5-HT(1A) partial agonist. Several more years had to pass before it was accepted that this receptor plays the key role in the action mechanism of buspirone. This was followed by further surprises. It was discovered that in spite of its anxiolytic effect buspirone activates the hypothalamic-pituitary-adrenal (HPA) stress axis, furthermore, it increases peripheral noradrenaline and adrenaline concentration via a central mechanism. Thus activation of this receptor leads to ACTH/corticosterone and catecholamine release and also increases beta-endorphine, oxytocin and prolactin secretion while decreasing body temperature, increasing food uptake, eliciting characteristic behavioural responses in rodents and also playing a role in the development of certain types of epilepsy. Human genetic studies revealed the role of 5-HT(1A) receptors in cognitive processes playing a role in the development of depression such as impulsiveness or response to environmental stress. This exceptionally wide spectrum of effects is attributable to the presence of 5-HT1A receptors in serotonergic as well as other, for example glutamatergic, cholinergic, dopaminergic and noradrenergic neurons. The majority of the effects of 5-HT(1A) receptors is manifested via the mediation of Gi proteins through the hyperpolarisation or inhibition of the neuron carrying the receptor. 5-HT(1A) receptors on serotonergic neurons can be found in the somatodendritic area and play a significant role in delaying the effects of antidepressants which is an obvious disadvantage. Therefore the newest serotonergic antidepressants including vilazodone and vortioxetine have been designed to possess 5-HT(1A) receptor partial agonist properties. In the present paper we focus primarily on the role of 5-HT(1A) receptors in stress and

  18. The Algorithm Theoretical Basis Document for Level 1A Processing

    NASA Technical Reports Server (NTRS)

    Jester, Peggy L.; Hancock, David W., III

    2012-01-01

    The first process of the Geoscience Laser Altimeter System (GLAS) Science Algorithm Software converts the Level 0 data into the Level 1A Data Products. The Level 1A Data Products are the time ordered instrument data converted from counts to engineering units. This document defines the equations that convert the raw instrument data into engineering units. Required scale factors, bias values, and coefficients are defined in this document. Additionally, required quality assurance and browse products are defined in this document.

  19. Mutations in the Microtubule-Associated Protein 1A (Map1a) Gene Cause Purkinje Cell Degeneration

    PubMed Central

    Liu, Ye; Lee, Jeong Woong

    2015-01-01

    The structural microtubule-associated proteins (MAPs) are critical for the organization of neuronal microtubules (MTs). Microtubule-associated protein 1A (MAP1A) is one of the most abundantly expressed MAPs in the mammalian brain. However, its in vivo function remains largely unknown. Here we describe a spontaneous mouse mutation, nm2719, which causes tremors, ataxia, and loss of cerebellar Purkinje neurons in aged homozygous mice. The nm2719 mutation disrupts the Map1a gene. We show that targeted deletion of mouse Map1a gene leads to similar neurodegenerative defects. Before neuron death, Map1a mutant Purkinje cells exhibited abnormal focal swellings of dendritic shafts and disruptions in axon initial segment (AIS) morphology. Furthermore, the MT network was reduced in the somatodendritic and AIS compartments, and both the heavy and light chains of MAP1B, another brain-enriched MAP, was aberrantly distributed in the soma and dendrites of mutant Purkinje cells. MAP1A has been reported to bind to the membrane-associated guanylate kinase (MAGUK) scaffolding proteins, as well as to MTs. Indeed, PSD-93, the MAGUK specifically enriched in Purkinje cells, was reduced in Map1a−/− Purkinje cells. These results demonstrate that MAP1A functions to maintain both the neuronal MT network and the level of PSD-93 in neurons of the mammalian brain. PMID:25788676

  20. PRKAR1A and the evolution of pituitary tumors.

    PubMed

    Kirschner, Lawrence S

    2010-09-15

    Carney complex (CNC) is an inherited tumor predisposition associated with pituitary tumors, including GH-producing pituitary adenomas and rare reports of prolactinomas. This disease is caused by mutations in PRKAR1A, which encodes the type 1A regulatory subunit of the cAMP-dependent protein kinase, PKA. Loss of PRKAR1A causes enhanced PKA signaling, which leads to pituitary tumorigenesis. Mutations in the gene have not been detected in sporadic pituitary tumors, but there is some data to suggest that non-genomic mechanisms may cause loss of protein expression. Unlike CNC patients, mice heterozygous for Prkar1a mutations do not develop pituitary tumors, although complete knockout of the gene in the Pit1 lineage of the pituitary produces GH-secreting pituitary adenomas. These data indicate that complete loss of Prkar1a/PRKAR1A is able to cause pituitary tumors in mice and men. The pattern of tumors is likely related to the signaling pathways employed in specific pituitary cell types. PMID:20451576

  1. Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility.

    PubMed

    Meredith, David M; Borromeo, Mark D; Deering, Tye G; Casey, Bradford H; Savage, Trisha K; Mayer, Paul R; Hoang, Chinh; Tung, Kuang-Chi; Kumar, Manonmani; Shen, Chengcheng; Swift, Galvin H; Macdonald, Raymond J; Johnson, Jane E

    2013-08-01

    The lineage-specific basic helix-loop-helix transcription factor Ptf1a is a critical driver for development of both the pancreas and nervous system. How one transcription factor controls diverse programs of gene expression is a fundamental question in developmental biology. To uncover molecular strategies for the program-specific functions of Ptf1a, we identified bound genomic regions in vivo during development of both tissues. Most regions bound by Ptf1a are specific to each tissue, lie near genes needed for proper formation of each tissue, and coincide with regions of open chromatin. The specificity of Ptf1a binding is encoded in the DNA surrounding the Ptf1a-bound sites, because these regions are sufficient to direct tissue-restricted reporter expression in transgenic mice. Fox and Sox factors were identified as potential lineage-specific modifiers of Ptf1a binding, since binding motifs for these factors are enriched in Ptf1a-bound regions in pancreas and neural tube, respectively. Of the Fox factors expressed during pancreatic development, Foxa2 plays a major role. Indeed, Ptf1a and Foxa2 colocalize in embryonic pancreatic chromatin and can act synergistically in cell transfection assays. Together, these findings indicate that lineage-specific chromatin landscapes likely constrain the DNA binding of Ptf1a, and they identify Fox and Sox gene families as part of this process. PMID:23754747

  2. Talking about the Weather, Part II.

    ERIC Educational Resources Information Center

    Gibb, Allan A.

    1984-01-01

    This second part of a two-part article highlights some mathematics involved in the study of meteorology. Examples are given of the application of mathematics to the study of the atmosphere, with three problems discussed. (MNS)

  3. Actual to expected studies--Part 1.

    PubMed

    Wesley, David; Cox, Hugh

    2014-01-01

    In this Part 1 of a two-part series, pivot tables are used to analyze mortality and then a step-by-step process is demonstrated of converting seriatim data that is suitable for pivot table analysis. PMID:25816466

  4. Voice Teachers on Voice, Part 3

    ERIC Educational Resources Information Center

    Gollobin, Laurie Brooks; White, Harvey

    1978-01-01

    Concludes a three-part symposium with eight prominent voice teachers on voice teaching methods. In this part, the teachers discuss placement, voice breaks, tone deafness, covered tone, and developing volume and offer some final general comments. (Editor)

  5. Holding fixture for variable-contour parts

    NASA Technical Reports Server (NTRS)

    Haynie, C. C.; Packer, P. N.; Zebus, P. P.

    1979-01-01

    Array of vacuum cups on spindles holds parts for safe machining and other processings. Variable-contour part resting on fixture is held firmly enough for machining, coating, or other mechanical treatment.

  6. STS-39 AFP-675 CIRRIS-1A in OV-103's payload bay (PLB)

    NASA Technical Reports Server (NTRS)

    1991-01-01

    STS-39's Air Force Program 675 (AFP-675) Uniformly Redundant Array (URA) and Cryogenic Infrared Radiance Instrumentation for Shuttle 1A (CIRRIS-1A) mounted on the experiment support system (ESS) pallet are documented in Discovery's, Orbiter Vehicle (OV) 103's, payload bay (PLB). Part of the ESS pallet power distribution system thermal covering is visible at the bottom of the frame. AFP-675 is a Department of Defense (DOD)-sponsored collection of experiments whose objective is to gather data on the Earth's atmosphere (aurora, Earth limb, and airglow), celestial objects, and the environment in and around the PLB. In the background are the aft PLB bulkhead, the vertical tail, and the orbital maneuvering system (OMS) pods.

  7. Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds

    SciTech Connect

    Zhang Xiaowei; Moore, Jeremy N.; Newsted, John L.; Hecker, Markus Zwiernik, Matthew J.; Jones, Paul D.; Bursian, Steven J.

    2009-02-01

    As part of an ongoing effort to understand aryl hydrocarbon receptor (AhR) mediated toxicity in mink, cDNAs encoding for CYP1A1 and the CYP1A2 mixed function monooxygenases were cloned and characterized. In addition, the effects of selected dibenzofurans on the expression of these genes and the presence of their respective proteins (P4501A) were investigated, and then correlated with the catalytic activities of these proteins as measured by ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-deethylase (MROD) activities. The predicted protein sequences for CYP1A1 and CYP1A2 comprise 517 and 512 amino acid residues, respectively. The phylogenetic analysis of the mink CYP1As with protein sequences of other mammals revealed high sequence homology with sea otter, seals and the dog, with amino acid identities ranging from 89 to 95% for CYP1A1 and 81 to 93% for CYP1A2. Since exposure to both 2,3,7,8-Tetrachlorodibenzofuran (TCDF) and 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) resulted in dose-dependent increases of CYP1A1 mRNA, CYP1A2 mRNA and CYP1A protein levels an underlying AhR-mediated mechanism is suggested. The up-regulation of CYP1A mRNA in liver was more consistent to the sum adipose TEQ concentration than to the liver TEQ concentration in minks treated with TCDF or PeCDF. The result suggested that the hepatic-sequestered fraction of PeCDF was biologically inactive to the induction of CYP1A1 and CYP1A2.

  8. 20 CFR 801.3 - Applicability of this part to 20 CFR part 802.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Applicability of this part to 20 CFR part 802. 801.3 Section 801.3 Employees' Benefits BENEFITS REVIEW BOARD, DEPARTMENT OF LABOR ESTABLISHMENT AND OPERATION OF THE BOARD Introductory § 801.3 Applicability of this part to 20 CFR part 802. Part 802 of...

  9. 49 CFR 236.505 - Proper operative relation between parts along roadway and parts on locomotive.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Proper operative relation between parts along... § 236.505 Proper operative relation between parts along roadway and parts on locomotive. Proper operative relation between the parts along the roadway and the parts on the locomotive shall obtain...

  10. UGT1A1 genotype and irinotecan therapy: general review and implementation in routine practice.

    PubMed

    Etienne-Grimaldi, Marie-Christine; Boyer, Jean-Christophe; Thomas, Fabienne; Quaranta, Sylvie; Picard, Nicolas; Loriot, Marie-Anne; Narjoz, Céline; Poncet, Delphine; Gagnieu, Marie-Claude; Ged, Cécile; Broly, Franck; Le Morvan, Valérie; Bouquié, Régis; Gaub, Marie-Pierre; Philibert, Laurent; Ghiringhelli, François; Le Guellec, Chantal

    2015-06-01

    Irinotecan is a major drug in the treatment of advanced colorectal cancer. Its active form is the SN38 metabolite, which is cleared by the biliary route after glucuronidation by uridine diphosphate-glucuronosyltransferase 1A1 (UGT1A1). UGT1A1 activity exhibits a wide intersubject variability, in part related to UGT1A1 gene polymorphisms. The present review on the impact of the deficient UGT1A1*28 variant on irinotecan efficacy and toxicity was produced by a French joint workgroup comprising the Group of Clinical Onco-pharmacology (GPCO-Unicancer) and the National Pharmacogenetics Network (RNPGx). It clearly emerges that for irinotecan doses at least equal to 180 mg/m(2) , patients homozygous for the UGT1A1*28 allele are at increased risk of developing hematological and/or digestive toxicities. Irinotecan dose reduction is thus recommended in homozygous *28/*28 patients. In addition, this personalized medicine strategy aims to secure high-dose irinotecan administration (≥240 mg/m(2) ) that have proven to be safe in homozygous *1/*1 patients only. The clinical relevance of this test is discussed in terms of treatment efficacy improvement, as increasing the irinotecan dose appears to be safe in patients not bearing a deficient allele. Best execution practices, cost-effectiveness, and result interpretation are discussed with the aim of facilitating the implementation of this analysis in clinical practice. The existence of networks of laboratories performing this test in routine hospital treatment, as in France, offers the prospect of widespread screening, thus guaranteeing equal access to safe treatment and optimized therapy for patients receiving irinotecan-based therapy in advanced colorectal cancer. PMID:25817555

  11. Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas

    PubMed Central

    Van Goietsenoven, Gwendoline; Hutton, Jenna; Becker, Jean-Paul; Lallemand, Benjamin; Robert, Francis; Lefranc, Florence; Pirker, Christine; Vandenbussche, Guy; Van Antwerpen, Pierre; Evidente, Antonio; Berger, Walter; Prévost, Martine; Pelletier, Jerry; Kiss, Robert; Goss Kinzy, Terri; Kornienko, Alexander; Mathieu, Véronique

    2010-01-01

    Melanomas display poor response rates to adjuvant therapies because of their intrinsic resistance to proapoptotic stimuli. This study indicates that such resistance can be overcome, at least partly, through the targeting of eEF1A elongation factor with narciclasine, an Amaryllidaceae isocarbostyril controlling plant growth. Narciclasine displays IC50 growth inhibitory values between 30–100 nM in melanoma cell lines, irrespective of their levels of resistance to proapoptotic stimuli. Normal noncancerous cell lines are much less affected. At nontoxic doses, narciclasine also significantly improves (P=0.004) the survival of mice bearing metastatic apoptosis-resistant melanoma xenografts in their brain. The eEF1A targeting with narciclasine (50 nM) leads to 1) marked actin cytoskeleton disorganization, resulting in cytokinesis impairment, and 2) protein synthesis impairment (elongation and initiation steps), whereas apoptosis is induced at higher doses only (≥200 nM). In addition to molecular docking validation and identification of potential binding sites, we biochemically confirmed that narciclasine directly binds to human recombinant and yeast-purified eEF1A in a nanomolar range, but not to actin or elongation factor 2, and that 5 nM narciclasine is sufficient to impair eEF1A-related actin bundling activity. eEF1A is thus a potential target to combat melanomas regardless of their apoptosis-sensitivity, and this finding reconciles the pleiotropic cytostatic of narciclasine.—Van Goietsenoven, G., Hutton, J., Becker, J.-P., Lallemand, B., Robert, F., Lefranc, F., Pirker, C., Vandenbussche, G., Van Antwerpen, P., Evidente, A., Berger, W., Prévost, M., Pelletier, J., Kiss, R., Goss Kinzy, T., Kornienko, A., Mathieu, V. Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas. PMID:20643906

  12. Part C Updates. 10th Edition

    ERIC Educational Resources Information Center

    Goode, Sue; Lazara, Alex; Danaher, Joan

    2008-01-01

    "Part C Updates" is a compilation of information on various aspects of the Early Intervention Program for Infants and Toddlers with Disabilities (Part C) of the Individuals with Disabilities Education Act (IDEA). This is the tenth volume in a series of compilations, which included two editions of Part H Updates, the former name of the program.…

  13. Saturated Vapour Pressure and Refrigeration - Part I

    ERIC Educational Resources Information Center

    Bunker, C. A.

    1973-01-01

    The first part of a two-part article describes an experimental approach that can be used in teaching the concept of saturated vapour pressure. This leads to a discussion of refrigeration cycles in the second part of the article. (JR)

  14. 49 CFR Appendix to Part 10 - Exemptions

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Exemptions Appendix to Part 10 Transportation Office of the Secretary of Transportation MAINTENANCE OF AND ACCESS TO RECORDS PERTAINING TO INDIVIDUALS Pt. 10, App. Appendix to Part 10—Exemptions Part I. General Exemptions Those portions of the following systems of records that consist of...

  15. Parts, Cavities, and Object Representation in Infancy

    ERIC Educational Resources Information Center

    Hayden, Angela; Bhatt, Ramesh S.; Kangas, Ashley; Zieber, Nicole

    2011-01-01

    Part representation is not only critical to object perception but also plays a key role in a number of basic visual cognition functions, such as figure-ground segregation, allocation of attention, and memory for shapes. Yet, virtually nothing is known about the development of part representation. If parts are fundamental components of object shape…

  16. 49 CFR Appendix to Part 10 - Exemptions

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Exemptions Appendix to Part 10 Transportation Office of the Secretary of Transportation MAINTENANCE OF AND ACCESS TO RECORDS PERTAINING TO INDIVIDUALS Pt. 10, App. Appendix to Part 10—Exemptions Part I. General Exemptions Those portions of the following systems of records that consist of...

  17. Some Aspects of Part-Time Work.

    ERIC Educational Resources Information Center

    Australian Dept. of Labour and National Service, Melbourne. Women's Bureau.

    Of major importance to many married women seeking employment in Australia is the availability of part-time work. To describe the economic aspects of part-time employment for women, a review was made of statistics published by the Commonwealth Bureau of Census and Statistics and of research on part-time employment in overseas countries, and a…

  18. Legislation and Part-Time Employment.

    ERIC Educational Resources Information Center

    Petersen, Allan L.; And Others

    This document presents an analysis of part-time employment issues in California community colleges, including a review of historical developments of the law covering the employment of certificated personnel, a review of some benefits and problems associated with part-time teaching, and consideration of part-time faculty employment as a major issue…

  19. 30 CFR 33.38 - Electrical parts.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... § 33.38 Electrical parts. (a) Units with electrical parts and designed to operate as electric face... Part 18 of Subchapter D of this chapter (Bureau of Mines Schedule 2, revised, the current revision of... opening (including electric-drive units with their controls and push buttons) are not required to...

  20. 30 CFR 33.38 - Electrical parts.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... § 33.38 Electrical parts. (a) Units with electrical parts and designed to operate as electric face... Part 18 of Subchapter D of this chapter (Bureau of Mines Schedule 2, revised, the current revision of... opening (including electric-drive units with their controls and push buttons) are not required to...

  1. 30 CFR 33.38 - Electrical parts.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... § 33.38 Electrical parts. (a) Units with electrical parts and designed to operate as electric face... Part 18 of Subchapter D of this chapter (Bureau of Mines Schedule 2, revised, the current revision of... opening (including electric-drive units with their controls and push buttons) are not required to...

  2. 30 CFR 33.38 - Electrical parts.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... § 33.38 Electrical parts. (a) Units with electrical parts and designed to operate as electric face... Part 18 of Subchapter D of this chapter (Bureau of Mines Schedule 2, revised, the current revision of... opening (including electric-drive units with their controls and push buttons) are not required to...

  3. 30 CFR 33.38 - Electrical parts.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... § 33.38 Electrical parts. (a) Units with electrical parts and designed to operate as electric face... Part 18 of Subchapter D of this chapter (Bureau of Mines Schedule 2, revised, the current revision of... opening (including electric-drive units with their controls and push buttons) are not required to...

  4. 7 CFR 1206.14 - Part.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.14 Part. Part means part 1206 which includes the Mango Promotion, Research, and Information Order and all rules, regulations, and...

  5. 7 CFR 1206.14 - Part.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.14 Part. Part means part 1206 which includes the Mango Promotion, Research, and Information Order and all rules, regulations, and...

  6. 7 CFR 1206.14 - Part.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.14 Part. Part means part 1206 which includes the Mango Promotion, Research, and Information Order and all rules, regulations, and...

  7. 7 CFR 1206.14 - Part.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.14 Part. Part means part 1206 which includes the Mango Promotion, Research, and Information Order and all rules, regulations, and...

  8. 7 CFR 1206.14 - Part.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE MANGO PROMOTION, RESEARCH, AND INFORMATION Mango Promotion, Research, and Information Order Definitions § 1206.14 Part. Part means part 1206 which includes the Mango Promotion, Research, and Information Order and all rules, regulations, and...

  9. Part C Updates. 11th Edition

    ERIC Educational Resources Information Center

    Danaher, Joan; Goode, Sue; Lazara, Alex

    2010-01-01

    "Part C Updates" is a compilation of information on various aspects of the Early Intervention Program for Infants and Toddlers with Disabilities (Part C) of the Individuals with Disabilities Education Act (IDEA). This is the eleventh volume in a series of compilations, which included two editions of Part H Updates, the former name of the program.…

  10. 40 CFR Appendix - Tables to Part 132

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 23 2013-07-01 2013-07-01 false Tables to Part 132 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS WATER QUALITY GUIDANCE FOR THE GREAT LAKES SYSTEM Application of part 132 requirements in Great Lakes States and Tribes. Pt. 132, Tables Tables to Part 132 Table 1—Acute Water...

  11. UGT1A1*28 and other UGT1A polymorphisms as determinants of irinotecan toxicity.

    PubMed

    Biason, P; Masier, S; Toffoli, G

    2008-04-01

    Irinotecan is a drug commonly used for the treatment of cancer patients, both as a single agent or in combination therapy. Neutropenia and diarrhea are the dose-limiting toxicities. Genetic variations of proteins involved in irinotecan metabolism and transport have been considered in the development of irinotecan toxicity. In particular, polymorphisms affecting UDP-glucuronosyltransferase isoform 1A1 (UGT1A1) expression or activity are being investigated. Among these, UGT1A1*28 has been considered as the major predictive pharmacogenetic marker for severe hematological toxicity (neutropenia). However, translation to clinical practice of UGT1A1*28 testing as a predictive marker of adverse effects needs to be further investigated and the available data are not conclusive in defining a precise genotype-based dosage. Further prospective studies are required to reach a personalization of chemotherapy with irinotecan. PMID:18467239

  12. Intravital imaging of Bacillus thuringiensis Cry1A toxin binding sites in the midgut of silkworm.

    PubMed

    Li, Na; Wang, Jing; Han, Heyou; Huang, Liang; Shao, Feng; Li, Xuepu

    2014-02-15

    Identification of the resistance mechanism of insects against Bacillus thuringiensis Cry1A toxin is becoming an increasingly challenging task. This fact highlights the need for establishing new methods to further explore the molecular interactions of Cry1A toxin with insects and the receptor-binding region of Cry1A toxins for their wider application as biopesticides and a gene source for gene-modified crops. In this contribution, a quantum dot-based near-infrared fluorescence imaging method has been applied for direct dynamic tracking of the specific binding of Cry1A toxins, CrylAa and CrylAc, to the midgut tissue of silkworm. The in vitro fluorescence imaging displayed the higher binding specificity of CrylAa-QD probes compared to CrylAc-QD to the brush border membrane vesicles of midgut from silkworm. The in vivo imaging demonstrated that more CrylAa-QDs binding to silkworm midgut could be effectively and distinctly monitored in living silkworms. Furthermore, frozen section analysis clearly indicated the broader receptor-binding region of Cry1Aa compared to that of Cry1Ac in the midgut part. These observations suggest that the insecticidal activity of Cry toxins may depend on the receptor-binding sites, and this scatheless and visual near-infrared fluorescence imaging could provide a new avenue to study the resistance mechanism to maintain the insecticidal activity of B. thuringiensis toxins. PMID:24252542

  13. Detection of a novel mutation in the CACNA1A gene.

    PubMed

    Stuart, Shani; Roy, Bishakha; Davies, Gail; Maksemous, Nevene; Smith, Robert; Griffiths, Lyn R

    2012-02-01

    Familial hemiplegic migraine (FHM) is a rare autosomal dominant subtype of migraine with aura. It is divided into three subtypes FHM1, FHM2 and FHM3, which are caused by mutations in the CACNA1A, ATP1A2 and SCN1A genes respectively. As part of a regular diagnostic service, we investigated 168 patients with FHM symptoms. Samples were tested for mutations contained within the CACNA1A gene. Some tested samples (4.43%) showed an FHM1 mutation, with five of the mutations found in exon 5, one mutation in exon 16 and one in exon 17. Four polymorphisms were also detected, one of which occurred in a large percentage of samples (14.88%). The exon 16 2094G>A polymorphism, however, has been found to occur in healthy Caucasian control populations up to a frequency of 16% and is not considered to be significantly associated with FHM. A finding of significance, found in a single patient, was the detection of a novel mutation in exon 5 that results in a P225H change. The affected individual was an 8-year-old female. The exact phenotypic effect of this mutation is unknown, and further studies are needed to understand the pathophysiology of this mutation in FHM1. New information will allow for diagnostic procedures to be constantly updated, thus improving accuracy of diagnosis. It is possible that new information will also aid the development of new therapeutic agents for the treatment of FHM. PMID:22784462

  14. SOX2 suppresses CDKN1A to sustain growth of lung squamous cell carcinoma

    PubMed Central

    Fukazawa, Takuya; Guo, Minzhe; Ishida, Naomasa; Yamatsuji, Tomoki; Takaoka, Munenori; Yokota, Etsuko; Haisa, Minoru; Miyake, Noriko; Ikeda, Tomoko; Okui, Tatsuo; Takigawa, Nagio; Maeda, Yutaka; Naomoto, Yoshio

    2016-01-01

    Since the SOX2 amplification was identified in lung squamous cell carcinoma (lung SCC), SOX2 transcriptional downstream targets have been actively investigated; however, such targets are often cell line specific. Here, in order to identify highly consensus SOX2 downstream genes in lung SCC cells, we used RNA-seq data from 178 lung SCC specimens (containing tumor and tumor-associated cells) and analyzed the correlation between SOX2 and previously-reported SOX2-controlled genes in lung SCC. In addition, we used another RNA-seq dataset from 105 non-small cell lung cancer cell lines (NSCLC; including 4 lung SCC cell lines) and again analyzed the correlation between SOX2 and the reported SOX2-controlled genes in the NSCLC cell lines (no tumor-associated cells). We combined the two analyses and identified genes commonly correlated with SOX2 in both datasets. Among the 99 genes reported as SOX2 downstream and/or correlated genes, we found 4 negatively-correlated (e.g., CDKN1A) and 11 positively-correlated genes with SOX2. We used biological studies to demonstrate that CDKN1A was suppressed by SOX2 in lung SCC cells. G1 cell cycle arrest induced by SOX2 siRNA was rescued by CDKN1A siRNA. These results indicate that the tumorigenic effect of SOX2 in lung SCC cells is mediated in part by suppression of CDKN1A. PMID:26846300

  15. BOREAS RSS-14 Level 1a GOES-7 Visible, IR, and Water Vapor Images

    NASA Technical Reports Server (NTRS)

    Hall, Forrest G. (Editor); Newcomer, Jeffrey A.; Faysash, David; Cooper, Harry J.; Smith, Eric A.

    2000-01-01

    The BOREAS RSS-14 team collected and processed GOES-7 and -8 images of the BOREAS region as part of its effort to characterize the incoming, reflected, and emitted radiation at regional scales. The level-1a BOREAS GOES-7 image data were collected by RSS-14 personnel at FSU and processed to level-1a products by BORIS personnel. The data cover the period of 01-Jan-1994 through 08-Jul-1995 with partial to complete coverage on the majority of the days. The data include three bands with eightbit pixel values. No major problems with the data have been identified. Due to the large size of the images, the level-1a GOES-7 data are not contained on the BOREAS CD-ROM set. An inventory listing file is supplied on the CD-ROM to inform users of what data were collected. The level-1a GOES-7 image data are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). See sections 15 and 16 for more information. The data files are available on a CD-ROM (see document number 20010000884).

  16. 40 CFR Table 1a to Subpart Ce of... - Emissions Limits for Small, Medium, and Large HMIWI at Designated Facilities as Defined in § 60...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Large HMIWI at Designated Facilities as Defined in § 60.32e(a)(1) 1A Table 1A to Subpart Ce of Part 60... for Small, Medium, and Large HMIWI at Designated Facilities as Defined in § 60.32 e ( a )(1) Pollutant Units(7 percent oxygen, dry basis) Emissions limits HMIWI size Small Medium Large Averaging time...

  17. 40 CFR Table 1a to Subpart Ce of... - Emissions Limits for Small, Medium, and Large HMIWI at Designated Facilities as Defined in § 60...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 7 2014-07-01 2014-07-01 false Emissions Limits for Small, Medium, and Large HMIWI at Designated Facilities as Defined in § 60.32e(a)(1) 1A Table 1A to Subpart Ce of Part 60 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) STANDARDS OF PERFORMANCE FOR NEW...

  18. 40 CFR Table 1a to Subpart Zzzz of... - Emission Limitations for Existing, New, and Reconstructed Spark Ignition, 4SRB Stationary RICE...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Internal Combustion Engines Pt. 63, Subpt. ZZZZ, Table 1a Table 1a to Subpart ZZZZ of Part 63—Emission... petition the Administrator pursuant to the requirements of 40 CFR 63.6(g) for alternative work practices. ... emissions by 75 percent or more until June 15, 2007 or Minimize the engine's time spent at idle and...

  19. 40 CFR Table 1a to Subpart Zzzz of... - Emission Limitations for Existing, New, and Reconstructed Spark Ignition, 4SRB Stationary RICE...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Internal Combustion Engines Pt. 63, Subpt. ZZZZ, Table 1a Table 1a to Subpart ZZZZ of Part 63—Emission... petition the Administrator pursuant to the requirements of 40 CFR 63.6(g) for alternative work practices. ... emissions by 75 percent or more until June 15, 2007 or Minimize the engine's time spent at idle and...

  20. 40 CFR Table 1a to Subpart Zzzz of... - Emission Limitations for Existing, New, and Reconstructed Spark Ignition, 4SRB Stationary RICE...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Internal Combustion Engines Pt. 63, Subpt. ZZZZ, Table 1a Table 1a to Subpart ZZZZ of Part 63—Emission... petition the Administrator pursuant to the requirements of 40 CFR 63.6(g) for alternative work practices. ... emissions by 75 percent or more until June 15, 2007 or Minimize the engine's time spent at idle and...

  1. 40 CFR Table 1a to Subpart Zzzz of... - Emission Limitations for Existing, New, and Reconstructed Spark Ignition, 4SRB Stationary RICE...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 14 2013-07-01 2013-07-01 false Emission Limitations for Existing, New, and Reconstructed Spark Ignition, 4SRB Stationary RICE > 500 HP Located at a Major Source of HAP Emissions 1a Table 1a to Subpart ZZZZ of Part 63 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS...

  2. The Alpha-1A Adrenergic Receptor in the Rabbit Heart

    PubMed Central

    Myagmar, Bat-Erdene; Swigart, Philip M.; Baker, Anthony J.; Simpson, Paul C.

    2016-01-01

    The alpha-1A-adrenergic receptor (AR) subtype is associated with cardioprotective signaling in the mouse and human heart. The rabbit is useful for cardiac disease modeling, but data on the alpha-1A in the rabbit heart are limited. Our objective was to test for expression and function of the alpha-1A in rabbit heart. By quantitative real-time reverse transcription PCR (qPCR) on mRNA from ventricular myocardium of adult male New Zealand White rabbits, the alpha-1B was 99% of total alpha-1-AR mRNA, with <1% alpha-1A and alpha-1D, whereas alpha-1A mRNA was over 50% of total in brain and liver. Saturation radioligand binding identified ~4 fmol total alpha-1-ARs per mg myocardial protein, with 17% alpha-1A by competition with the selective antagonist 5-methylurapidil. The alpha-1D was not detected by competition with BMY-7378, indicating that 83% of alpha-1-ARs were alpha-1B. In isolated left ventricle and right ventricle, the selective alpha-1A agonist A61603 stimulated a negative inotropic effect, versus a positive inotropic effect with the nonselective alpha-1-agonist phenylephrine and the beta-agonist isoproterenol. Blood pressure assay in conscious rabbits using an indwelling aortic telemeter showed that A61603 by bolus intravenous dosing increased mean arterial pressure by 20 mm Hg at 0.14 μg/kg, 10-fold lower than norepinephrine, and chronic A61603 infusion by iPRECIO programmable micro Infusion pump did not increase BP at 22 μg/kg/d. A myocardial slice model useful in human myocardium and an anthracycline cardiotoxicity model useful in mouse were both problematic in rabbit. We conclude that alpha-1A mRNA is very low in rabbit heart, but the receptor is present by binding and mediates a negative inotropic response. Expression and function of the alpha-1A in rabbit heart differ from mouse and human, but the vasopressor response is similar to mouse. PMID:27258143

  3. The Alpha-1A Adrenergic Receptor in the Rabbit Heart.

    PubMed

    Thomas, R Croft; Cowley, Patrick M; Singh, Abhishek; Myagmar, Bat-Erdene; Swigart, Philip M; Baker, Anthony J; Simpson, Paul C

    2016-01-01

    The alpha-1A-adrenergic receptor (AR) subtype is associated with cardioprotective signaling in the mouse and human heart. The rabbit is useful for cardiac disease modeling, but data on the alpha-1A in the rabbit heart are limited. Our objective was to test for expression and function of the alpha-1A in rabbit heart. By quantitative real-time reverse transcription PCR (qPCR) on mRNA from ventricular myocardium of adult male New Zealand White rabbits, the alpha-1B was 99% of total alpha-1-AR mRNA, with <1% alpha-1A and alpha-1D, whereas alpha-1A mRNA was over 50% of total in brain and liver. Saturation radioligand binding identified ~4 fmol total alpha-1-ARs per mg myocardial protein, with 17% alpha-1A by competition with the selective antagonist 5-methylurapidil. The alpha-1D was not detected by competition with BMY-7378, indicating that 83% of alpha-1-ARs were alpha-1B. In isolated left ventricle and right ventricle, the selective alpha-1A agonist A61603 stimulated a negative inotropic effect, versus a positive inotropic effect with the nonselective alpha-1-agonist phenylephrine and the beta-agonist isoproterenol. Blood pressure assay in conscious rabbits using an indwelling aortic telemeter showed that A61603 by bolus intravenous dosing increased mean arterial pressure by 20 mm Hg at 0.14 μg/kg, 10-fold lower than norepinephrine, and chronic A61603 infusion by iPRECIO programmable micro Infusion pump did not increase BP at 22 μg/kg/d. A myocardial slice model useful in human myocardium and an anthracycline cardiotoxicity model useful in mouse were both problematic in rabbit. We conclude that alpha-1A mRNA is very low in rabbit heart, but the receptor is present by binding and mediates a negative inotropic response. Expression and function of the alpha-1A in rabbit heart differ from mouse and human, but the vasopressor response is similar to mouse. PMID:27258143

  4. 40 CFR Appendix A to Subpart Bb of... - Applicability of General Provisions (40 CFR Part 63, Subpart A) to Subpart BB

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... (40 CFR Part 63, Subpart A) to Subpart BB A Appendix A to Subpart BB of Part 63 Protection of... to Subpart BB of Part 63—Applicability of General Provisions (40 CFR Part 63, Subpart A) to Subpart BB 40 CFR citation Requirement Applies to subpart BB Comment 63.1(a)(1) through (4)...

  5. 40 CFR Appendix A to Subpart Bb of... - Applicability of General Provisions (40 CFR Part 63, Subpart A) to Subpart BB

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... (40 CFR Part 63, Subpart A) to Subpart BB A Appendix A to Subpart BB of Part 63 Protection of... to Subpart BB of Part 63—Applicability of General Provisions (40 CFR Part 63, Subpart A) to Subpart BB 40 CFR citation Requirement Applies to subpart BB Comment 63.1(a)(1) through (4)...

  6. 40 CFR Appendix A to Subpart Bb of... - Applicability of General Provisions (40 CFR Part 63, Subpart A) to Subpart BB

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... (40 CFR Part 63, Subpart A) to Subpart BB A Appendix A to Subpart BB of Part 63 Protection of... to Subpart BB of Part 63—Applicability of General Provisions (40 CFR Part 63, Subpart A) to Subpart BB 40 CFR citation Requirement Applies to subpart BB Comment 63.1(a)(1) through (4)...

  7. Sulf1A and HGF regulate satellite-cell growth

    PubMed Central

    Gill, Roop; Hitchins, Laura; Fletcher, Fenella; Dhoot, Gurtej K.

    2010-01-01

    The role of Sulf1A, sulfation and hepatocyte growth factor (HGF) in satellite-cell growth was examined in an in vitro model of dissociated whole skeletal muscle fibres. Pax7-positive quiescent satellite cells express little or no Sulf1A but show rapid re-expression in regenerating myoblasts and myotubes, similar to embryonic muscle and in vitro satellite cells preceding asynchronous MyoD activation. Once activated, Sulf1A and MyoD re-expression persists up to 72 hours in most satellite cells under normal culture conditions and following moderate changes in sulfation, whereas Sulf1A neutralisation by antibodies not only enhances satellite-cell proliferation but also downregulates MyoD and Pax7 expression in a large proportion of the satellite cells. The HGF exposure also induces similar but even more pronounced changes characterised by variable sulfation levels and rapid downregulation of MyoD and Pax7 without myogenin activation in a sub-set of cells. This Pax7-MyoD-myogenin-negative sub-population expresses Sulf1A and Myf5. The transfer of all such satellite-cell progenies onto gelatin-coated-substratum re-activates MyoD and Pax7 gene expression in all cells, thus detecting a distinct sub-population of satellite cells. We conclude that HGF and fine-tuned sulfation levels are major contributory factors controlling satellite-cell growth by regulating the relative activities of actively proliferating and differentiating cells. PMID:20442248

  8. Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts

    PubMed Central

    Morse, David; Webster, Wesley; Kalanon, Ming; Langsley, Gordon; McFadden, Geoffrey I.

    2016-01-01

    Over-expression of a GFP-PfRab1A fusion protein in Plasmodium falciparum schizonts produces a punctate pattern of fluorescence typical of rhoptries, secretory organelles involved in host cell invasion. The GFP-positive bodies were purified by a combination of differential and density gradient centrifugation and their protein content determined by MS/MS sequencing. Consistent with the GFP rhoptry-like pattern of transgenic parasites, four of the 19 proteins identified have been previously described to be rhoptry-associated and another four are ER or ER-associated proteins. Confirmation that GFP-PfRab1A decorates rhoptries was obtained by its co-localization with Rap1 and Ron4 in late phase schizonts. We conclude that PfRab1A potentially regulates vesicular traffic from the endoplasmic reticulum to the rhoptries in Apicomplexa parasites. PMID:27348424

  9. The 5-HT1A receptor in Major Depressive Disorder.

    PubMed

    Kaufman, Joshua; DeLorenzo, Christine; Choudhury, Sunia; Parsey, Ramin V

    2016-03-01

    Major Depressive Disorder (MDD) is a highly prevalent psychiatric diagnosis that is associated with a high degree of morbidity and mortality. This debilitating disorder is currently one of the leading causes of disability nationwide and is predicted to be the leading cause of disease burden by the year 2030. A large body of previous research has theorized that serotonergic dysfunction, specifically of the serotonin (5-HT) 1A receptor, plays a key role in the development of MDD. The purpose of this review is to describe the evolution of our current understanding of the serotonin 1A (5-HT1A) receptor and its role in the pathophysiology MDD through the discussion of animal, post-mortem, positron emission tomography (PET), pharmacologic and genetic studies. PMID:26851834

  10. Novel PRKAR1A gene mutations in Carney Complex.

    PubMed

    Pan, Lorraine; Peng, Lan; Jean-Gilles, J; Zhang, Ximin; Wieczorek, Rosemary; Jain, Shilpa; Levine, Vicki; Osman, Iman; Prieto, Victor G; Lee, Peng

    2010-01-01

    Carney complex is a syndrome that may include cardiac and mucocutaneous myxomas, spotting skin pigmentation, and endocrine lesions. Many patients with Carney complex have been shown to have a stop codon mutation in the PRKAR1A gene in the 17q22-24 region. Here we present the case of a 57 year-old man with multiple skin lesions and cardiac myxomas. Histology of the skin lesions showed lentigenous melanocytic hyperplasia and cutaneous myxomas, confirming the diagnosis of Carney complex. Lesional and control normal tissue from the patient were identified and sequenced for the PRKAR1A gene. A germline missense mutation was identified at exon 1A. This is the first report of this mutation, and one of the few reported missense mutation associated with Carney complex. This finding strengthens the argument that there are alternative ways in which the protein kinase A 1-alpha subunit plays a role in tumorigenesis. PMID:20606737

  11. It is time to beelieve the CD1a hype!

    PubMed

    Krovi, Sai Harsha; Gapin, Laurent

    2016-01-01

    Conventional T cells have historically been linked to exacerbating allergy. By efficiently generating primarily TH 2 cells, allergens skew the immune response to produce IL-4, IL-13, and IgE. Previously, CD1a-responsive T cells were shown to functionally respond to bee and wasp venom allergens. In this issue of the European Journal of Immunology, Subramaniam et al. [Eur. J. Immunol. 2016. 46: 242-252] show that more functionally active CD1a-restricted cells are present in bee venom-allergic patients than in healthy patients. Additionally, the authors show that these cells are not as frequently found in individuals receiving venom immunotherapy. Consequently, this study implicates CD1a-reactive cells as the primary responders to venom allergy, which considerably regulate the downstream immune response. PMID:26617406

  12. SUMOylation of Syntaxin1A regulates presynaptic endocytosis

    PubMed Central

    Craig, Tim J.; Anderson, Dina; Evans, Ashley J.; Girach, Fatima; Henley, Jeremy M.

    2015-01-01

    Neurotransmitter release from the presynaptic terminal is under very precise spatial and temporal control. Following neurotransmitter release, synaptic vesicles are recycled by endocytosis and refilled with neurotransmitter. During the exocytosis event leading to release, SNARE proteins provide most of the mechanical force for membrane fusion. Here, we show one of these proteins, Syntaxin1A, is SUMOylated near its C-terminal transmembrane domain in an activity-dependent manner. Preventing SUMOylation of Syntaxin1A reduces its interaction with other SNARE proteins and disrupts the balance of synaptic vesicle endo/exocytosis, resulting in an increase in endocytosis. These results indicate that SUMOylation regulates the emerging role of Syntaxin1A in vesicle endocytosis, which in turn, modulates neurotransmitter release and synaptic function. PMID:26635000

  13. Mechanism of dual specificity kinase activity of DYRK1A.

    PubMed

    Walte, Agnes; Rüben, Katharina; Birner-Gruenberger, Ruth; Preisinger, Christian; Bamberg-Lemper, Simone; Hilz, Nikolaus; Bracher, Franz; Becker, Walter

    2013-09-01

    The function of many protein kinases is controlled by the phosphorylation of a critical tyrosine residue in the activation loop. Dual specificity tyrosine-phosphorylation-regulated kinases (DYRKs) autophosphorylate on this tyrosine residue but phosphorylate substrates on aliphatic amino acids. This study addresses the mechanism of dual specificity kinase activity in DYRK1A and related kinases. Tyrosine autophosphorylation of DYRK1A occurred rapidly during in vitro translation and did not depend on the non-catalytic domains or other proteins. Expression in bacteria as well as in mammalian cells revealed that tyrosine kinase activity of DYRK1A is not restricted to the co-translational autophosphorylation in the activation loop. Moreover, mature DYRK1A was still capable of tyrosine autophosphorylation. Point mutants of DYRK1A and DYRK2 lacking the activation loop tyrosine showed enhanced tyrosine kinase activity. A series of structurally diverse DYRK1A inhibitors was used to pharmacologically distinguish different conformational states of the catalytic domain that are hypothesized to account for the dual specificity kinase activity. All tested compounds inhibited substrate phosphorylation with higher potency than autophosphorylation but none of the tested inhibitors differentially inhibited threonine and tyrosine kinase activity. Finally, the related cyclin-dependent kinase-like kinases (CLKs), which lack the activation loop tyrosine, autophosphorylated on tyrosine both in vitro and in living cells. We propose a model of DYRK autoactivation in which tyrosine autophosphorylation in the activation loop stabilizes a conformation of the catalytic domain with enhanced serine/threonine kinase activity without disabling tyrosine phosphorylation. The mechanism of dual specificity kinase activity probably applies to related serine/threonine kinases that depend on tyrosine autophosphorylation for maturation. PMID:23809146

  14. D-1A nose fairing separation fitting load test

    NASA Technical Reports Server (NTRS)

    Vanvleet, J. O.

    1976-01-01

    Structural testing of the D-1A Centaur nose fairing was completed to determine the loads imposed during flight on the latch bolts of the fairing separation system. This testing was conducted to supplement and/or verify the analytic techniques used in calculating bolt loads for the D-1A, and to gain insight into the general structural behavior of separation latch systems. It was shown that the assumed bolt load magnification due to prying action of the latch fittings on the bolt does occur, but is strongly dependent on fairing shell stiffness.

  15. 5-hydroxytryptamine1A (5-HT1A) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma.

    PubMed

    Cheng, Jeffrey P; Leary, Jacob B; Sembhi, Aerin; Edwards, Clarice M; Bondi, Corina O; Kline, Anthony E

    2016-06-01

    Traumatic brain injury (TBI) is a significant and enduring health care issue with limited treatment options. While several pre-clinical therapeutic approaches have led to enhanced motor and/or cognitive performance, the benefits of these treatments have not translated to the clinic. One plausible explanation is that the therapies may not have been rigorously evaluated, thus rendering the bench-to-bedside leap premature and subsequently unsuccessful. An approach that has undergone considerable empirical research after TBI is pharmacological targeting of 5-HT1A receptors with agonists such as repinotan HCl, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), and buspirone. The goal of this review is to integrate and interpret the findings from a series of studies that evaluated the efficacy of 5-HT1A receptor agonists on functional, histological, and molecular outcome after acquired brain injury. The overwhelming consensus of this exhaustive review is that a decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma. This article is part of a Special Issue entitled SI:Brain injury and recovery. PMID:26612522

  16. Psychotropics regulate Skp1a, Aldh1a1, and Hspa8 transcription--potential to delay Parkinson's disease.

    PubMed

    Lauterbach, Edward C

    2013-01-10

    Recently, the genes p19 S-phase kinase-associated protein 1A (SKP1), huntingtin interacting protein-2 (UBE2K), aldehyde dehydrogenase family 1 subfamily A1 (ALDH1A1), 19 S proteasomal protein PSMC4, and heat shock 70-kDa protein 8 (HSPA8) have been found to predict the onset and progression of Parkinson's disease (PD). These findings prompted a review of the effects of commonly prescribed psychiatric medicines, drugs that are used in treating PD, on the expression of these genes. Findings in the published medical literature were reviewed and gene expression data in the Gene Expression Omnibus Profiles database were analyzed. The results indicate that fluoxetine upregulated the risk-attenuating genes Skp1a and Aldh1a1 and olanzapine downregulated risk-enhancing Hspa8 while also downregulating Aldh1a1. Less conclusive evidence suggested that fluoxetine might also downregulate Hspa8 and clozapine might downregulate risk-enhancing Ube2k, but that olanzapine might upregulate Ube2k. Together, the present findings suggest that these psychotropics may delay PD onset (fluoxetine, olanzapine, and perhaps clozapine) and progression (fluoxetine, clozapine, and perhaps olanzapine). These gene expression findings should be replicated by RT-PCR studies in humans and, if confirmed, these drugs should then be studied in animal models and PD patients. PMID:23046827

  17. Pig melatonin receptor 1a (MTNR1A) genotype is associated with seasonal variation of sow litter size.

    PubMed

    Ramírez, O; Tomàs, A; Barragan, C; Noguera, J L; Amills, M; Varona, L

    2009-10-01

    The duration of nocturnal melatonin secretion reaches its minimum in summer, a physiological event that is likely related with the diminished sow fertility and delayed puberty typically observed in this season. Melatonin exerts its function by binding two different receptors named as MTNR1A and MTNR1B. Interestingly, the MTNR1A gene is located on a chromosome SSC17 region where QTL for prolificacy traits have been detected in previous studies. In this work, we have found a synonymous T162C polymorphism at exon 2 of the pig MTNR1A gene. An association analysis between this polymorphism and sow prolificacy in an Iberianx Meishan intercross was performed. The utilization of four statistical models of increasing complexity demonstrated that the MTNR1A gene has both additive and dominant effects on total number of born piglets (TNB) and number of piglets born alive (NBA). Additive effects were significant in summer (TNB, P<0.01; NBA, P<0.001), whereas dominant effects reached significance both in fall (TNB, P<0.01; NBA, P<0.05) and in winter (TNB, P<0.001; NBA, P<0.05). The seasonal variation observed for MTNR1A additive and dominant effects might be produced by the influence of photoperiod on the pattern and duration of melatonin secretion. These results illustrate that the complex interaction between genotype and environment can be an important source of phenotypic variation of reproductive traits. PMID:19181464

  18. Identification of Myb-binding protein 1A (MYBBP1A) as a novel substrate for aurora B kinase.

    PubMed

    Perrera, Claudia; Colombo, Riccardo; Valsasina, Barbara; Carpinelli, Patrizia; Troiani, Sonia; Modugno, Michele; Gianellini, Laura; Cappella, Paolo; Isacchi, Antonella; Moll, Jurgen; Rusconi, Luisa

    2010-04-16

    Aurora kinases are mitotic enzymes involved in centrosome maturation and separation, spindle assembly and stability, and chromosome condensation, segregation, and cytokinesis and represent well known targets for cancer therapy because their deregulation has been linked to tumorigenesis. The availability of suitable markers is of crucial importance to investigate the functions of Auroras and monitor kinase inhibition in in vivo models and in clinical trials. Extending the knowledge on Aurora substrates could help to better understand their biology and could be a source for clinical biomarkers. Using biochemical, mass spectrometric, and cellular approaches, we identified MYBBP1A as a novel Aurora B substrate and serine 1303 as the major phosphorylation site. MYBBP1A is phosphorylated in nocodazole-arrested cells and is dephosphorylated upon Aurora B silencing or by treatment with Danusertib, a small molecule inhibitor of Aurora kinases. Furthermore, we show that MYBBP1A depletion by RNA interference causes mitotic progression delay and spindle assembly defects. MYBBP1A has until now been described as a nucleolar protein, mainly involved in transcriptional regulation. The results presented herein show MYBBP1A as a novel Aurora B kinase substrate and reveal a not yet recognized link of this nucleolar protein to mitosis. PMID:20177074

  19. Sequence variants at CYP1A1–CYP1A2 and AHR associate with coffee consumption

    PubMed Central

    Sulem, Patrick; Gudbjartsson, Daniel F.; Geller, Frank; Prokopenko, Inga; Feenstra, Bjarke; Aben, Katja K.H.; Franke, Barbara; den Heijer, Martin; Kovacs, Peter; Stumvoll, Michael; Mägi, Reedik; Yanek, Lisa R.; Becker, Lewis C.; Boyd, Heather A.; Stacey, Simon N.; Walters, G. Bragi; Jonasdottir, Adalbjorg; Thorleifsson, Gudmar; Holm, Hilma; Gudjonsson, Sigurjon A.; Rafnar, Thorunn; Björnsdottir, Gyda; Becker, Diane M.; Melbye, Mads; Kong, Augustine; Tönjes, Anke; Thorgeirsson, Thorgeir; Thorsteinsdottir, Unnur; Kiemeney, Lambertus A.; Stefansson, Kari

    2011-01-01

    Coffee is the most commonly used stimulant and caffeine is its main psychoactive ingredient. The heritability of coffee consumption has been estimated at around 50%. We performed a meta-analysis of four genome-wide association studies of coffee consumption among coffee drinkers from Iceland (n = 2680), the Netherlands (n = 2791), the Sorbs Slavonic population isolate in Germany (n = 771) and the USA (n = 369) using both directly genotyped and imputed single nucleotide polymorphisms (SNPs) (2.5 million SNPs). SNPs at the two most significant loci were also genotyped in a sample set from Iceland (n = 2430) and a Danish sample set consisting of pregnant women (n = 1620). Combining all data, two sequence variants significantly associated with increased coffee consumption: rs2472297-T located between CYP1A1 and CYP1A2 at 15q24 (P = 5.4 · 10−14) and rs6968865-T near aryl hydrocarbon receptor (AHR) at 7p21 (P = 2.3 · 10−11). An effect of ∼0.2 cups a day per allele was observed for both SNPs. CYP1A2 is the main caffeine metabolizing enzyme and is also involved in drug metabolism. AHR detects xenobiotics, such as polycyclic aryl hydrocarbons found in roasted coffee, and induces transcription of CYP1A1 and CYP1A2. The association of these SNPs with coffee consumption was present in both smokers and non-smokers. PMID:21357676

  20. Carnitine palmitoyl transferase-1A (CPT1A): a new tumor specific target in human breast cancer

    PubMed Central

    Zonetti, Maria Josè; Fisco, Tommaso; Polidoro, Chiara; Bocchinfuso, Gianfranco; Palleschi, Antonio; Novelli, Giuseppe; Spagnoli, Luigi G.

    2016-01-01

    Transcriptional mechanisms epigenetically-regulated in tumoral tissues point out new targets for anti-cancer therapies. Carnitine palmitoyl transferase I (CPT1) is the rate-limiting enzyme in the transport of long-chain fatty acids for β-oxidation. Here we identified the tumor specific nuclear CPT1A as a product of the transcript variant 2, that doesn't retain the classical transferase activity and is strongly involved in the epigenetic regulation of cancer pro-survival, cell death escaping and tumor invasion pathways. The knockdown of CPT1A variant 2 by small interfering RNAs (siRNAs), was sufficient to induce apoptosis in MCF-7, SK-BR3 and MDA-MB-231 breast cancer cells. The cell death triggered by CPT1A silencing correlated with reduction of HDAC activity and histone hyperacetylation. Docking experiments and molecular dynamics simulations confirmed an high binding affinity of the variant 2 for HDAC1. The CPT1A silenced cells showed an up-regulated transcription of pro-apoptotic genes (BAD, CASP9, COL18A1) and down-modulation of invasion and metastasis related-genes (TIMP-1, PDGF-A, SERPINB2). These findings provide evidence of the CPT1 variant 2 involvement in breast cancer survival, cell death escape and invasion. Thus, we propose nuclear CPT1A as a striking tumor specific target for anticancer therapeutics, more selective and effective as compared with the well-known HDAC inhibitors. PMID:26799588

  1. Isolation and characterization of three cassava elongation factor 1 alpha (MeEF1A) promoters.

    PubMed

    Suhandono, Sony; Apriyanto, Ardha; Ihsani, Nisa

    2014-01-01

    In plant genetic engineering, the identification of gene promoters leading to particular expression patterns is crucial for the development of new genetically modified plant generations. This research was conducted in order to isolate and characterize several new promoters from cassava (Manihot esculenta Crantz) elongation factor 1 alpha (EF1A) gene family.Three promoters MeEF1A3, MeEF1A5 and MeEF1A6 were successfully isolated [corrected]. Sequence analyses showed that all of the promoters contain three conserved putative cis-acting elements which are located upstream of the transcription start site. These elements are included a TEF1, a TELO and TATA boxes. In addition, all of the promoters also have the 5'UTR intron but with a different lengths. These promoters were constructed translationally with gusA reporter gene (promoter::gusA fusion) in pBI-121 binary vector to build a new binary vector using Overlap Extension PCR Cloning (OEPC) technique. Transient expression assay that was done by using agroinfiltration method was used to show functionality of these promoters. Qualitative and quantitative analysis from GUS assay showed that these promoters were functional and conferred a specific activity in tobacco seedlings (Nicotiana tabacum), tomato fruits (Solanum lycopersicum) and banana fruits (Musa acuminata). We hypothesized that MeEF1A6 could be categorized as a constitutive promoter because it was able to drive the gene expression in all transformed tissue described in here and also comparable to CaMV35S. On the other hand, MeEF1A3 drove specific expression in the aerial parts of seedlings such as hypocotyl and cotyledon thus MeEF1A5 drove specific expression in fruit tissue. The results obtained from transient analysis showed that these promoters had a distinct activity although they came from same gene family. The DNA sequences identified here are new promoters potentially use for genetic engineering in cassava or other plants. PMID:24404183

  2. Extracting fields snow coverage information with HJ-1A/B satellites data

    NASA Astrophysics Data System (ADS)

    Dong, Wenquan; Meng, Jihua

    2015-10-01

    The distribution and change of snow coverage are sensitive factors of climate change. In northeast part of China, farmlands are still covered with snow in spring. Since sowing activity can only be done when the snow melted, fields snow coverage monitoring provides reference for the determination of sowing date. Because of the restriction of the sensors and application requirements, current researches on remote sensing of snow focus more on the study of musicale and large scale, rather than the study of small scale, and especially research on snow melting period is rarely reported.HJ-1A/B satellites are parts of little satellite constellation, focusing on environment and disaster monitoring and meteorological forecast. Compared to other data sources, HJ-1A/B satellites both have comparatively higher temporal and spatial resolution and are more conducive to monitor the variations of melting snow coverage at small watershed. This paper was based on HJ-1A/1B data, taking Hongxing farm of Bei'an, Heilongjiang Province, China as the study area. In this paper, we exploited the methods for extraction of snow cover information on farmland in two cases, both HJ-1A/1B CCD with HJ-1B IRS data and just HJ-1A/1B CCD data. The reason we chose the two cases is that, the two optical satellites HJ-1A/B are capable of providing a whole territory coverage period in visible light spectrum in two days, infrared spectrum in four days. So sometimes we can only obtain CCD image. In this case, the method of normalized snow index cannot be used to extract snow coverage information. Using HJ-1A/1B CCD with HJ-1B IRS data, combined with the theory of snow remote sensing monitoring, this paper analyzed spectral response characteristics of HJ-1A/1B satellites data, then the widely used Normalized Difference Snow Index(NDSI) and S3 Index were quoted to the HJ-1A/1B satellites data. The NDSI uses reflectance values of Red and SWIR spectral bands of HJ-1B, and S3 index uses reflectance values of

  3. Using partial sensor information to orient parts

    SciTech Connect

    Akella, S.; Mason, M.T.

    1999-10-01

    Parts orienting, the process of bringing parts in initially unknown orientations to a goal orientation, is an important aspect of automated assembly. The most common industrial orienting systems are vibratory bowl feeders, which use the shape and mass properties of parts to orient them. Bowl feeders rely on a sequence of mechanical operations and typically do not use sensors. In this paper, the authors describe the use of partial information sensors along with a sequence of pushing operations to eliminate uncertainty in the orientation of parts. The authors characterize the shorter execution lengths of sensor-based plans and show that sensor-based plans are more powerful than sensorless plans in that they can bring a larger class of parts to distinct orientations. The authors characterize the relation among part shape, orientability; and recognizability to identify conditions under which a single plan can orient and recognize multiple part shapes. Although part shape determines the results of the actions and the sensed information, the authors establish that differences in part shape do not always lead to differences in part behavior. The authors show that for any convex polygon, there exists an infinite set of nonsimilar convex polygons that behave identically under linear normal pushes. Furthermore, there exists a infinite set of nonsimilar convex polygons whose behavior cannot be distinguished even with diameter sensing after each push. They authors have implemented several planners and demonstrated generated plans in experiments.

  4. Calcium kinetics in glycogen storage disease type 1a.

    PubMed

    Goans, R E; Weiss, G H; Vieira, N E; Sidbury, J B; Abrams, S A; Yergey, A L

    1996-12-01

    Glycogen storage disease type 1a (Von Gierke's disease) is one of the more common glycogen storage diseases (GSD). GSD 1a patients can have severe idiopathic osteopenia, often beginning at a young age. Since calcium tracer studies offer a sensitive probe of the bone microenvironment and of calcium deposition, kinetics might be disturbed in patients with GSD 1a. Plasma dilution kinetics obtained using the stable isotope 42Ca are shown in this paper to be quite different between GSD 1a patients and age-matched controls. Comparison of kinetic parameters in these two populations is made using a new binding site model for describing calcium dynamics at the plasma-bone interface. This model describes reversible binding of calcium ions to postulated short-term and long-term sites by a retention probability density function psi (t). Using this analysis, adult GSD subjects exhibited a significant decrease (P = 0.023) in the apparent half-life of a calcium ion on the longer-term site compared with controls. The general theory of calcium tracer dilution kinetics is then discussed in terms of a new model of short-term calcium homeostasis recently proposed by Bronner and Stein [5]. PMID:8939770

  5. The Allosteric Binding Sites of Sulfotransferase 1A1

    PubMed Central

    Cook, Ian; Wang, Ting; Falany, Charles N.

    2015-01-01

    Human sulfotransferases (SULTs) comprise a small, 13-member enzyme family that regulates the activities of thousands of compounds—endogenous metabolites, drugs, and other xenobiotics. SULTs transfer the sulfuryl-moiety (–SO3) from a nucleotide donor, PAPS (3′-phosphoadenosine 5′-phosphosulfate), to the hydroxyls and primary amines of acceptors. SULT1A1, a progenitor of the family, has evolved to sulfonate compounds that are remarkably structurally diverse. SULT1A1, which is found in many tissues, is the predominant SULT in liver, where it is a major component of phase II metabolism. Early work demonstrated that catechins and nonsteroidal anti-inflammatory drugs inhibit SULT1A1 and suggested that the inhibition was not competitive versus substrates. Here, the mechanism of inhibition of a single, high affinity representative from each class [epigallocatechin gallate (EGCG) and mefenamic acid] is determined using initial-rate and equilibrium-binding studies. The findings reveal that the inhibitors bind at sites separate from those of substrates, and at saturation turnover of the enzyme is reduced to a nonzero value. Further, the EGCG inhibition patterns suggest a molecular explanation for its isozyme specificity. Remarkably, the inhibitors bind at sites that are separate from one another, and binding at one site does not affect affinity at the other. For the first time, it is clear that SULT1A1 is allosterically regulated, and that it contains at least two, functionally distinct allosteric sites, each of which responds to a different class of compounds. PMID:25534770

  6. Design and Interpretation of Human Sulfotransferase 1A1 Assays.

    PubMed

    Wang, Ting; Cook, Ian; Leyh, Thomas S

    2016-04-01

    The human sulfotransferases (SULTs) regulate the activities of hundreds, if not thousands, of small molecule metabolites via transfer of the sulfuryl-moiety (-SO3) from the nucleotide donor, 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the hydroxyls and amines of the recipients. Our understanding of the molecular basis of SULT catalysis has expanded considerably in recent years. The basic kinetic mechanism of these enzymes, previously thought to be ordered, has been redefined as random for SULT2A1, a representative member of the superfamily. An active-site cap whose structure and dynamics are highly responsive to nucleotides was discovered and shown to be critical in determining SULT selectivity, a topic of longstanding interest to the field. We now realize that a given SULT can operate in two specificity modes-broad and narrow-depending on the disposition of the cap. More recent work has revealed that the caps of the SULT1A1 are controlled by homotropic allosteric interactions between PAPS molecules bound at the dimer's active sites. These interactions cause the catalytic efficiency of SULT1A1 to vary in a substrate-dependent fashion by as much as two orders of magnitude over a range of PAPS concentrations that spans those found in human tissues. SULT catalysis is further complicated by the fact that these enzymes are frequently inhibited by their substrates. This review provides an overview of the mechanistic features of SULT1A1 that are important for the design and interpretation of SULT1A1 assays. PMID:26658224

  7. Parkinson's disease and CYP1A2 activity

    PubMed Central

    Forsyth, J T; Grünewald, R A; Rostami-Hodjegan, A; Lennard, M S; Sagar, H J; Tucker, G T

    2000-01-01

    Aims MPTP, a neurotoxin which induces parkinsonism is partially metabolized by the enzyme CYP1A2. Smoking appears to protect against Parkinson's disease (PD) and cigarette smoke induces CYP1A2 activity. Thus, we investigated the hypothesis that idiopathic PD is associated with lower CYP1A2 activity using caffeine as a probe compound. Methods CYP1A2 activity was assessed using saliva paraxanthine (PX) to caffeine (CA) ratios. Caffeine half-life was also estimated from salivary concentrations of caffeine at 2 and 5 h post dose. 117 treated and 40 untreated patients with PD and 105 healthy control subjects were studied. Results PX/CA ratios were 0.57, 0.93 and 0.77 in treated patients, untreated patients and healthy control subjects, respectively, with no significant differences between study groups (95% CI: treated patients vs controls −0.24, 0.57; untreated patients vs controls −0.75, 0.35). However, patients with PD (treated or untreated) had caffeine half-lives shorter than that in controls (treated patients: 262 min, untreated patients: 244 min, controls: 345 min; 95% CI: controls vs treated patients 23, 143 (P = 0.003); controls vs untreated patients 19, 184 (P = 0.011)). Amongst the patients with PD, caffeine half-life was also inversely related to the age of onset of disease (P = 0.012); gender and concomitant drugs did not influence this significantly. Conclusions Based on PX/CA ratio, there was no evidence of decreased CYP1A2 activity in patients compared with control subjects. The observed decrease in the elimination half-life of caffeine in PD may be caused by increased CYP2E1 activity, an enzyme that also contributes to the metabolism of caffeine. The latter warrants further investigation. PMID:11012552

  8. 33 CFR Appendix A to Part 385 - Illustrations to Part 385

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Illustrations to Part 385 A Appendix A to Part 385 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY.... A Appendix A to Part 385—Illustrations to Part 385 ER12NO03.000 ER12NO03.001...

  9. 45 CFR Appendix A to Part 1110 - Federal Financial Assistance to Which This Part Applies

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Federal Financial Assistance to Which This Part Applies A Appendix A to Part 1110 Public Welfare Regulations Relating to Public Welfare (Continued... Pt. 1110, App. A Appendix A to Part 1110—Federal Financial Assistance to Which This Part Applies...

  10. 47 CFR 27.1133 - Protection of Part 74 and Part 78 operations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false Protection of Part 74 and Part 78 operations... MHz Bands Protection of Incumbent Operations § 27.1133 Protection of Part 74 and Part 78 operations... stations with those licensees. In the event that mutually satisfactory coordination agreements cannot...

  11. 47 CFR 27.1133 - Protection of Part 74 and Part 78 operations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Protection of Part 74 and Part 78 operations... MHz Bands Protection of Incumbent Operations § 27.1133 Protection of Part 74 and Part 78 operations... stations with those licensees. In the event that mutually satisfactory coordination agreements cannot...

  12. Parts Engineering Experiences, Philosophies and Trends

    NASA Technical Reports Server (NTRS)

    Shaw, Harry; Day, John H. (Technical Monitor)

    2000-01-01

    This document is the presentation viewgraphs of the NASA presentations to NASDA, outlining the philosophy and trends of the experiences with engineering parts. Included in the presentations: are (1) the assurance of COTS boards for Space flight, and (2) Peer Review for Ice, Cloud and land Elevation Satellite (ICESat) GPS flight receivers EEE parts. The emphasis is on the methods for qualification of available parts for space flight.

  13. Machining Thin-Walled Cylindrical Parts

    NASA Technical Reports Server (NTRS)

    Cimbak, Joe; Spagnolo, Jim; Kraus, Dan

    1988-01-01

    Cylindrical walls only few thousandths of inch thick machined accurately and without tears or punctures with aid of beryllium copper mandrel. Chilled so it contracts, then inserted in cylinder. As comes to room temperature, mandrel expands and fits snugly inside cylinder. Will not allow part to slide and provides solid backup to prevent deflection when part machined by grinding wheel. When machining finished, cylinder-and-mandrel assembly inserted in dry ice, mandrel contracts and removed from part.

  14. Clinical Pharmacokinetics: A Simplified Approach, Part 2

    PubMed Central

    Perlin, Elliott; Taylor, Robert E.; Peck, Carl C.

    1986-01-01

    Part 1 of this two-part series in clinical pharmacokinetics (J Natl Med Assoc 1985; 77:475-482) introduced the clinician to the basic principles required for rational therapeutic drug management at the bedside. Practical problems were included that demonstrated how these principles could be put to clinical use. In Part 2 the clinical pharmacology of three commonly used drugs (theophylline, digoxin and gentamicin) are discussed, and practical problems are presented to illustrate the use of their pharmacokinetic profiles. PMID:3783759

  15. 49 CFR Appendix A-Ii to Part 541 - Lines With Antitheft Devices Which Are Exempted in-Part From the Parts-Marking Requirements of...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543 A Appendix A-II... STANDARD Pt. 541, App. A-II Appendix A-II to Part 541—Lines With Antitheft Devices Which Are Exempted in-Part From the Parts-Marking Requirements of This Standard Pursuant to 49 CFR Part 543...

  16. Metallic parts fabrication using the SIS process

    NASA Astrophysics Data System (ADS)

    Mojdeh, Mehdi

    Since early 1980s, quite a few techniques of Rapid Prototyping (RP), also known as Layered Manufacturing, have been developed. By building three-dimensional parts in a layer-by-layer additive manner, these techniques allow freeform fabrication of parts of complex geometry. Despite recent advances in fabrication of polymer parts, most of the existing rapid prototyping processes are still not capable of fabrication of accurate metallic parts with acceptable mechanical properties. Insufficient dimensional accuracy, limited number of materials, proper mechanical properties, required post machining and lack of repeatability between builds have greatly limited the market penetration of these techniques. This dissertation presents an innovative layered manufacturing technique for fabrication of dense metallic parts called Selective Inhibition Sintering (SIS), developed at the University of Southern California. The SIS-Metal technology adapts RP capabilities and extends them to the field of fabrication of metallic parts for a variety of applications such as tooling and low volume production. Using this process, a metallic part, with varying 3 dimensional geometries, can be automatically constructed from a wide range of materials. SIS-Metal is the only RP process which is suitable for fabrication of dense, complex shaped, accurate objects using a variety of materials. In the SIS-Metal process a metallic part is built layer by layer by deposition for each layer of an inhibitor material which defines the corresponding layer boundary and then filling the voids of the created geometry with metal powder; and compacting the layer formed to reach a high powder density. The resulting green part is then sintered in a furnace to yield the final functional part. In this research different inhibition techniques were explored and a series of single and multi layer parts was fabricated using the most promising inhibition technique, namely, macro-mechanical inhibition. Dimensional

  17. Reliability and quality EEE parts issues

    NASA Technical Reports Server (NTRS)

    Barney, Dan; Feigenbaum, Irwin

    1990-01-01

    NASA policy and procedures are established which govern the selection, testing, and application of electrical, electronic, and electromechanical (EEE) parts. Recent advances in the state-of-the-art of electronic parts and associated technologies can significantly impact the electronic designs and reliability of NASA space transportation avionics. Significant issues that result from these advances are examined, including: recent advances in microelectronics technology (as applied to or considered for use in NASA projects); electron packaging technology advances (concurrent with, and as a result of, the development of the advanced microelectronic devices); availability of parts used in space avionics; and standardization and integration of parts activities between projects, centers, and contractors.

  18. Opportunistic replacement of fusion power system parts

    SciTech Connect

    Day, J.A.; George, L.L.

    1981-10-26

    This paper describes a maintenance problem in a fusion power plant. The problem is to specify which life limited parts should be replaced when there is an opportunity. The objective is to minimize the cost rate of replacement parts and of maintenance actions while satisfying a power plant availability constraint. The maintenance policy is to look ahead and replace all parts that will reach their life limits within a time called a screen. Longer screens yield greater system availabilities because more parts are replaced prior to their life limits.

  19. NASA Electronic Parts and Packaging Program

    NASA Technical Reports Server (NTRS)

    Kayali, Sammy

    2000-01-01

    NEPP program objectives are to: (1) Access the reliability of newly available electronic parts and packaging technologies for usage on NASA projects through validations, assessments, and characterizations, and the development of test methods/tools; (2)Expedite infusion paths for advanced (emerging) electronic parts and packaging technologies by evaluations of readiness for manufacturability and project usage consideration; (3) Provide NASA projects with technology selection, application, and validation guidelines for electronic parts and packaging hardware and processes; nd (4) Retain and disseminate electronic parts and packaging quality assurance, reliability validations, tools, and availability information to the NASA community.

  20. Rotor instability due to loose rotating part

    NASA Technical Reports Server (NTRS)

    Muszynska, A.

    1985-01-01

    Loosening of a rotating part from its fixed position on the shaft or a part of the stator which comes loose and begins to turn with the rotor very frequently represents machinery malfunction. The loose part becomes involved in rotative motion mostly due to dry or fluid friction, and thus its motion is very erratic. The loose part can also move axially along the shaft. Detachment of the rotating part causes changes in the rotor balance state. Most often this results in higher unbalance. During steady-state operation the effect of a loose rotating part can manifest itself through heat vibration. It can be diagnosed by observing periodic changes of amplitude and phase of the synchronous response. During start-up (or shutdown) a loose rotating part carrying some amount of unbalance may manifest its dynamic action in the form of subsynchronous vibrations, very similar to those of other instabilities. The objective of this demonstration is to observe the effect of a loose rotating part (fixed, however, in the axial direction) under both steady-state (rotor constant speed) and transient (rotor start-up or shutdown) operation. The dynamic response depends very much on the amount of damping in the system: lubrication of the loose part/shaft surfaces and addition/elimination of aerodynamic drag blades, mounted on the loose disk, significantly change the rotor response.

  1. Efficacy of cardiac rehabilitation. 1: A critique of the research.

    PubMed

    Brennan, A

    This article, the first of two parts, suggests that cardiac rehabilitation has two primary foci: the reduction of morbidity and mortality, and the amelioration of distress associated with cardiac pathology. While exercise programmes figure prominently in cardiac rehabilitation, empirical studies attest to their relatively modest impact on the recurrence of myocardial infarction. Other interventions such as stress management programmes reduce psychological distress and increase effective coping mechanisms, but only for a limited period. Traditional educational programmes compare unfavourably with cognitive-behavioural interventions. Empirical research appraising the efficacy of many cardiac rehabilitation interventions are tainted by numerous design problems. The second part of this article considers research into the efficacy of smoking cessation and type A behaviour modification programmes. PMID:9238918

  2. Method of forming and assembly of metal parts and ceramic parts

    DOEpatents

    Ripley, Edward B.

    2011-11-22

    A method of forming and assembling at least two parts together that may be metal, ceramic, or a combination of metal and ceramic parts. Such parts may have different CTE. Individual parts that are formed and sintered from particles leave a network of interconnecting porosity in each sintered part. The separate parts are assembled together and then a fill material is infiltrated into the assembled parts using a method such as capillary action, gravity, and/or pressure. The assembly is then cured to yield a bonded and fully or near-fully dense part that has the desired physical and mechanical properties for the part's intended purpose. Structural strength may be added to the parts by the inclusion of fibrous materials.

  3. Evidence for the effect of serotonin receptor 1A gene (HTR1A) polymorphism on tractability in Thoroughbred horses.

    PubMed

    Hori, Y; Tozaki, T; Nambo, Y; Sato, F; Ishimaru, M; Inoue-Murayama, M; Fujita, K

    2016-02-01

    Tractability, or how easily animals can be trained and controlled, is an important behavioural trait for the management and training of domestic animals, but its genetic basis remains unclear. Polymorphisms in the serotonin receptor 1A gene (HTR1A) have been associated with individual variability in anxiety-related traits in several species. In this study, we examined the association between HTR1A polymorphisms and tractability in Thoroughbred horses. We assessed the tractability of 167 one-year-old horses reared at a training centre for racehorses using a questionnaire consisting of 17 items. A principal components analysis of answers contracted the data to five principal component (PC) scores. We genotyped two non-synonymous single nucleotide polymorphisms (SNPs) in the horse HTR1A coding region. We found that one of the two SNPs, c.709G>A, which causes an amino acid change at the intracellular region of the receptor, was significantly associated with scores of four of five PCs in fillies (all Ps < 0.05) and one PC in colts (P < 0.01). Horses carrying an A allele at c.709G>A showed lower tractability. This result provides the first evidence that a polymorphism in a serotonin-related gene may affect tractability in horses with the effect partially different depending on sex. PMID:26763159

  4. Immunoglobulin G response to mammalian cell entry 1A (Mce1A) protein as biomarker of active tuberculosis.

    PubMed

    Takenami, Iukary; de Oliveira, Carolina C; Lima, Filipe R; Soares, Jéssica; Machado, Almério; Riley, Lee W; Arruda, Sérgio

    2016-09-01

    Cell wall components are major determinants of virulence of Mycobacterium tuberculosis and they contribute to the induction of both humoral and cell-mediated immune response. The mammalian cell entry protein 1A (Mce1A), in the cell wall of M. tuberculosis, mediates entry of the pathogen into mammalian cells. Here, we examined serum immunoglobulin levels (IgA, IgM and total IgG) against Mce1A as a potential biomarker for diagnosis and monitoring tuberculosis (TB) treatment response. Serum samples of 39 pulmonary TB patients and 65 controls (15 healthy household contacts, 19 latently infected household contacts, 13 non-TB and 18 leprosy patients) were screened by ELISA. The median levels of all immunoglobulin classes were significantly higher in TB patients when compared with control groups. The positive test results for IgA, IgM and total IgG were 62, 54 and 82%, respectively. For comparison, routine sputum smear examination diagnosed only 26 (67%) of 39 TB cases. Sensitivities of IgA, IgM and IgG test were 59, 51.3 and 79.5%, respectively, while the specificities observed were 77.3, 83.3 and 84.4%, respectively. A significant decrease compared with baseline was also shown after TB treatment. These results suggest that circulating total IgG antibody to Mce1A could be a complementary tool to diagnosis pulmonary TB. PMID:27553414

  5. Centaur D-1A nose fairing jettison test

    NASA Technical Reports Server (NTRS)

    Prati, W. M.

    1976-01-01

    An experimental investigation was conducted to verify the functional and structural capability of the Centaur D-1A nose fairing. A full-scale flight-type nose fairing was jettisoned at the Lewis Research Center Space Power Chamber at simulated altitude. Two complete jettisons of the nose fairing were performed, one without aft helper springs and one with aft helper springs. A ''static'' rotation test was also performed to verify capability of the helper springs and to allow clearance measurements between the nose fairing and spacecraft envelope mock-up at certain discrete nose fairing rotation angles. Nose fairing trajectories, structural deflections, clearances, and hinge forces during jettison are presented. Data from subsequent Centaur D-1A flights, relative to nose fairing jettisons, are compared with the experimental results.

  6. Cooperative Force Generation of KIF1A Brownian Motors

    NASA Astrophysics Data System (ADS)

    Oriola, David; Casademunt, Jaume

    2013-07-01

    KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ˜10 monomeric KIF1As can team up to become ˜100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions.

  7. Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A

    PubMed Central

    Belyi, Yury; Niggeweg, Ricarda; Opitz, Bastian; Vogelsgesang, Martin; Hippenstiel, Stefan; Wilm, Matthias; Aktories, Klaus

    2006-01-01

    Legionella pneumophila, the causal agent of Legionnaires' disease, is an intracellular parasite and invades and proliferates within different eukaryotic cells, including human alveolar macrophages. After several 100-fold multiplication within host cells, the pathogens are released for new invasion by induction of apoptosis or necrosis. Here we report that L. pneumophila produces a glucosyltransferase, which selectively modifies an ≈50-kDa mammalian protein by using UDP-glucose as a cosubstrate. MS analysis identified the protein substrate as the mammalian elongation factor (EF)1A. Legionella glucosyltransferase modifies its eukaryotic protein substrate at serine-53, which is located in the GTPase domain of the EF. Glucosylation of EF1A results in inhibition of eukaryotic protein synthesis and death of target cells. Our findings show a mode of inhibition of protein synthesis by microbial pathogens and offer a perspective for understanding of the host-pathogen interaction of L. pneumophila. PMID:17068130

  8. Metrology of Large Parts. Chapter 5

    NASA Technical Reports Server (NTRS)

    Stahl, H. Philip

    2012-01-01

    As discussed in the first chapter of this book, there are many different methods to measure a part using optical technology. Chapter 2 discussed the use of machine vision to measure macroscopic features such as length and position, which was extended to the use of interferometry as a linear measurement tool in chapter 3, and laser or other trackers to find the relation of key points on large parts in chapter 4. This chapter looks at measuring large parts to optical tolerances in the sub-micron range using interferometry, ranging, and optical tools discussed in the previous chapters. The purpose of this chapter is not to discuss specific metrology tools (such as interferometers or gauges), but to describe a systems engineering approach to testing large parts. Issues such as material warpage and temperature drifts that may be insignificant when measuring a part to micron levels under a microscope, as will be discussed in later chapters, can prove to be very important when making the same measurement over a larger part. In this chapter, we will define a set of guiding principles for successfully overcoming these challenges and illustrate the application of these principles with real world examples. While these examples are drawn from specific large optical testing applications, they inform the problems associated with testing any large part to optical tolerances. Manufacturing today relies on micrometer level part performance. Fields such as energy and transportation are demanding higher tolerances to provide increased efficiencies and fuel savings. By looking at how the optics industry approaches sub-micrometer metrology, one can gain a better understanding of the metrology challenges for any larger part specified to micrometer tolerances. Testing large parts, whether optical components or precision structures, to optical tolerances is just like testing small parts, only harder. Identical with what one does for small parts, a metrologist tests large parts and optics

  9. Energetics of the single-headed kinesin KIF1A

    NASA Astrophysics Data System (ADS)

    Kanada, Ryo; Sasaki, Kazuo

    2013-08-01

    KIF1A is a single-headed molecular motor that moves processively and unidirectionally along a microtubule by using the chemical energy released by hydrolyzing adenosine triphosphate (ATP) into adenosine diphosphate (ADP) and inorganic phosphate (Pi). Although the movement of KIF1A seems to have successfully been explained by a simple Brownian motor model of the flashing ratchet type, this model is not suited to discuss the energetics of KIF1A. We introduce an elaborated model of the ratchet type to investigate how the chemical free energy is converted into mechanical work by taking account of the binding and release of reactant (ATP) and product (ADP and Pi) molecules to and from the motor. The efficiency of energy transduction, the power output, and other quantities are calculated from the analytically obtained steady-state solution of the Fokker-Planck equations. It turns out that the concentrations of the reactant and product molecules that optimize both the efficiency and the power are close to those in the cell.

  10. Aberrant expression of RAB1A in human tongue cancer

    PubMed Central

    Shimada, K; Uzawa, K; Kato, M; Endo, Y; Shiiba, M; Bukawa, H; Yokoe, H; Seki, N; Tanzawa, H

    2005-01-01

    This study was designed to identify specific gene expression changes in tongue squamous cell carcinomas (TSCCs) compared with normal tissues using in-house cDNA microarray that comprised of 2304 full-length cDNAs from a cDNA library prepared from normal oral tissues, primary oral cancers, and oral cancer cell lines. The genes identified by our microarray system were further analysed at the mRNA or protein expression level in a series of clinical samples by real-time quantitative reverse transcriptase–polymerase chain reaction (qRT–PCR) analysis and imuunohositochemistry. The microarray analysis identified a total of 16 genes that were significantly upregulated in common among four TSCC specimens. Consistent with the results of the microarray, increased mRNA levels of selected genes with known molecular functions were found in the four TSCCs. Among genes identified, Rab1a, a member of the Ras oncogene family, was further analysed for its protein expression in 54 TSCCs and 13 premalignant lesions. We found a high prevalence of Rab1A-overexpression not only in TSCCs (98%) but also in premalignant lesions (93%). Thus, our results suggest that rapid characterisation of the target gene(s) for TSCCs can be accomplished using our in-house cDNA microarray analysis combined with the qRT–PCR and immunohistochemistry, and that the Rab1A is a potential biomarker of tongue carcinogenesis. PMID:15870709

  11. Incomplete penetrance of biallelic ALDH1A3 mutations.

    PubMed

    Plaisancié, Julie; Brémond-Gignac, Dominique; Demeer, Bénédicte; Gaston, Véronique; Verloes, Alain; Fares-Taie, Lucas; Gerber, Sylvie; Rozet, Jean-Michel; Calvas, Patrick; Chassaing, Nicolas

    2016-04-01

    The formation of a properly shaped eye is a complex developmental event that requires the coordination of many induction processes and differentiation pathways. Microphthalmia and anophthalmia (MA) represent the most severe defects that can affect the ocular globe during embryonic development. When genetic, these ocular disorders exhibit large genetic heterogeneity and extreme variable expressivity. Around 20 monogenic diseases are known to be associated with MA as main phenotype and the penetrance of mutations is usually full in the patients. Some of these genes encode proteins involved in the vitamin A pathway, tightly regulated during eye development. One of those retinoic acid synthesis genes is ALDH1A3 and biallelic mutations in that gene have been recently found to lead to MA phenotype in patients. Interestingly, we report here the lack of ocular defect in a girl carrying the same homozygous mutation in the ALDH1A3 gene than the affected members of her family. Thus, this report brings new information for the phenotype-genotype correlation of ALDH1A3 mutations and raises important questions, especially in terms of genetic counselling given to the patients and their families. Furthermore, these data contribute to the more general understanding that we have for the complex genetic inheritance of these MA phenotypes. PMID:26873617

  12. Mutations in COL1A1 Gene Change Dentin Nanostructure.

    PubMed

    Duan, Xiaohong; Liu, Zhenxia; Gan, Yunna; Xia, Dan; Li, Qiang; Li, Yanling; Yang, Jiaji; Gao, Shan; Dong, Mingdong

    2016-04-01

    Although many studies have attempted to associate specific gene mutations with dentin phenotypic severity, it remains unknown how the mutations in COL1A1 gene influence the mechanical behavior of dentin collagen and matrix. Here, we reported one osteogenesis imperfecta (OI) pedigree caused by two new inserting mutations in exon 5 of COL1A1 (NM_000088.3:c.440_441insT;c.441_442insA), which resulted in the unstable expression of COL1A1 mRNA and half quantity of procollagen production. We investigated the morphological and mechanical features of proband's dentin using atomic force microscope (AFM), scanning electron microscope, and transmission electron microscope. Increased D-periodic spacing, variably enlarged collagen fibrils coating with fewer minerals were found in the mutated collagen. AFM analysis demonstrated rougher dentin surface and sparsely decreased Young's modulus in proband's dentin. We believe that our findings provide new insights into the genetic-/nano- mechanisms of dentin diseases, and may well explain OI dentin features with reduced mechanical strength and a lower crosslinked density. Anat Rec, 299:511-519, 2016. © 2015 Wiley Periodicals, Inc. PMID:26694865

  13. Overexpression of HSPA1A enhances the osteogenic differentiation of bone marrow mesenchymal stem cells via activation of the Wnt/β-catenin signaling pathway

    PubMed Central

    Zhang, Wei; Xue, Deting; Yin, Houfa; Wang, Shengdong; Li, Chao; Chen, Erman; Hu, Dongcai; Tao, Yiqing; Yu, Jiawei; Zheng, Qiang; Gao, Xiang; Pan, Zhijun

    2016-01-01

    HSPA1A, which encodes cognate heat shock protein 70, plays important roles in various cellular metabolic pathways. To investigate its effects on osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), its expression level was compared between undifferentiated and differentiated BMSCs. Rat HSPA1A overexpression in BMSCs increased osteoblast-specific gene expression, alkaline phosphatase activity, and mineral deposition in vitro. Moreover, it upregulated β-catenin and downregulated DKK1 and SOST. The enhanced osteogenesis due to HSPA1A overexpression was partly rescued by a Wnt/β-catenin inhibitor. Additionally, using a rat tibial fracture model, a sheet of HSPA1A-overexpressing BMSCs improved bone fracture healing, as determined by imaging and histological analysis. Taken together, these findings suggest that HSPA1A overexpression enhances osteogenic differentiation of BMSCs, partly through Wnt/β-catenin. PMID:27279016

  14. 49 CFR Appendix - Figures to Part 38

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 1 2012-10-01 2012-10-01 false Figures to Part 38 Transportation Office of the Secretary of Transportation AMERICANS WITH DISABILITIES ACT (ADA) ACCESSIBILITY SPECIFICATIONS FOR TRANSPORTATION VEHICLES Other Vehicles and Systems Trams, and similar vehicles, and systems Pt. 38, Figures Figures to Part 38 ER28SE98.000...

  15. 49 CFR Appendix - Figures to Part 38

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 1 2013-10-01 2013-10-01 false Figures to Part 38 Transportation Office of the Secretary of Transportation AMERICANS WITH DISABILITIES ACT (ADA) ACCESSIBILITY SPECIFICATIONS FOR TRANSPORTATION VEHICLES Other Vehicles and Systems Trams, and similar vehicles, and systems Pt. 38, Figures Figures to Part 38 ER28SE98.000...

  16. Search Engines for Tomorrow's Scholars, Part Two

    ERIC Educational Resources Information Center

    Fagan, Jody Condit

    2012-01-01

    This two-part article considers how well some of today's search tools support scholars' work. The first part of the article reviewed Google Scholar and Microsoft Academic Search using a modified version of Carole L. Palmer, Lauren C. Teffeau, and Carrier M. Pirmann's framework (2009). Microsoft Academic Search is a strong contender when…

  17. Part-Time Learners Need Support Too

    ERIC Educational Resources Information Center

    Fazackerley, Anna

    2009-01-01

    In England, part-time students have to pay their fees up-front, they can't take out a government-supported loan, and their chances of securing any financial support are depressingly slim. While all full-time students are entitled to some state support, Parliamentary questions have revealed that nine out of 10 part-time students receive nothing at…

  18. FOUNDATIONS OF THAI. BOOK I, PART 1.

    ERIC Educational Resources Information Center

    ANTHONY, EDWARD M.; AND OTHERS

    THIS BEGINNING TEXT PRESENTS THE ESSENTIALS OF THAI PRONUNCIATION AND GRAMMAR IN A FORMAT GEARED TO REGULAR COLLEGE LANGUAGE COURSE SCHEDULING. THE COURSE CONSISTS OF TWO VOLUMES, BOOK I, PART 1 (LESSONS 1-14) AND BOOK I, PART 2 (LESSONS 15-25), PROVIDING MATERIAL FOR TWO UNIVERSITY SEMESTERS OF CLASSROOM AND LABORATORY WORK. BASED ON A…

  19. Coal-fired power materials - Part II

    SciTech Connect

    Viswanathan, V.; Purgert, R.; Rawls, P.

    2008-09-15

    Part 1 discussed some general consideration in selection of alloys for advanced ultra supercritical (USC) coal-fired power plant boilers. This second part covers results reported by the US project consortium, which has extensively evaluated the steamside oxidation, fireside corrosion, and fabricability of the alloys selected for USC plants. 3 figs.

  20. Part Timers and University Faculty Development.

    ERIC Educational Resources Information Center

    Dick, Robert C.

    The increasing number of part-time faculty, especially in university speech communication departments, appears to provide vital continuity in professional development. There are three kinds of part-time faculty: those with new doctoral degrees who want to teach full time but who cannot find appointments, those who are still active or semiactive…

  1. 23 CFR Parts 1345-1399 - [RESERVED

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 23 Highways 1 2013-04-01 2013-04-01 false 1345 PARTS 1345-1399 Highways NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION UNIFORM CRITERIA FOR STATE OBSERVATIONAL SURVEYS OF SEAT BELT USE Administrative Requirements Annual reporting requirements. PARTS 1345-1399...

  2. Part Time Study in Higher Education.

    ERIC Educational Resources Information Center

    Neville, Colin

    This document, which is intended for adults considering enrolling in part-time study in higher education, examines the objectives and experiences of adults who have pursued part-time study in higher education in the United Kingdom. The following reasons why adults return to higher education are discussed: personal development; self-fulfillment;…

  3. PARTS: (Plasma Accelerated Reusable Transport System)

    NASA Astrophysics Data System (ADS)

    Aherne, Michael; Davis, Phil; England, Matt; Gustavsson, Jake; Pankow, Steve; Sampaio, Chere; Savella, Phil

    2002-01-01

    The Plasma Accelerated Reusable Transport System (PARTS) is an unmanned cargo shuttle intended to ferry large payloads to and from Martian orbit using a highly efficient VAriable Specific Impulse Magnetoplasma Rocket (VASIMR). The design of PARTS focuses on balancing cost and minimizing transit time for a chosen payload consisting of vehicles, satellites, and other components provided by interested parties.

  4. Part-Time Faculty Handbook: Jefferson College.

    ERIC Educational Resources Information Center

    Jefferson Coll., Hillsboro, MO.

    Designed for part-time faculty at Jefferson College, this handbook answers questions regarding institutional policies and procedures and offers tips to help part-time teachers provide the best possible teacher-learner climate, touching upon a wide variety of issues related to adult learners. The first section of the handbook contains practical…

  5. Preliminary Report on Part-Time Faculty.

    ERIC Educational Resources Information Center

    California Community Colleges, Sacramento.

    This report summarizes survey data on part-time faculty utilization in California community colleges. Data was received from 67 of the 69 community college districts. The primary purpose of the survey was to obtain information that would be useful to community college boards and administrators in dealing with part-time faculty legislation. Tables…

  6. A Theory of Intellectual Development: Part 1.

    ERIC Educational Resources Information Center

    Confrey, Jere

    1994-01-01

    Part 1 of a three-part article analyzing radical constructivism (as one interpretation of Piaget) and the socio-cultural perspective (as one interpretation of Vygotsky), including major principles, primary contributions to mathematics education, and potential limitations. Introduces an integration of the two theories through a feminist…

  7. [Basic lung ultrasound. Part 2. Parenchymal diseases].

    PubMed

    de la Quintana Gordon, F B; Nacarino Alcorta, B; Fajardo Pérez, M

    2015-01-01

    In this second part, an analysis is made of the pathology of lung parenchyma. This text is structured into different sections, including the study of atelectasias, pneumonia and abscess, interstitial/alveolar or Blines patterns, and finally an analysis is made of pulmonary embolism. With this second part, the basic knowledge to develop lung ultrasound in the anesthesia department has been presented. PMID:25708093

  8. Project Management; Part 1--The Soft Skills.

    ERIC Educational Resources Information Center

    Bailey, Harold J.; Ergott, Kathleen A.

    1998-01-01

    Presents the first of a three-part series of articles on the life of a project manager. Discussion in Part 1 deals with the people and related skills involved in the project, including: interrelationships between the client, project manager, and executive management; oral, written, and body-language communication forms; and planning and…

  9. 47 CFR Parts 401-499 - [RESERVED

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false 401 PARTS 401-499 Telecommunication NATIONAL TELECOMMUNICATIONS AND INFORMATION ADMINISTRATION, DEPARTMENT OF COMMERCE, AND NATIONAL HIGHWAY TRAFFIC SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION E-911 GRANT PROGRAM Closeout. PARTS 401-499...

  10. Coping Mechanisms of Part-Time Students

    ERIC Educational Resources Information Center

    Yum, Jessie C. K.; Kember, David; Siaw, Irene

    2005-01-01

    A characteristic shared by the majority of adult students is that they are undertaking part-time study. For these adult learners one of the major difficulties is how to find time for their study. This paper reports the coping mechanisms that part-time adult students adopt to meet the additional demands that study puts on their existing commitments…

  11. 47 CFR Alphabetical Index - Part 73

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 4 2012-10-01 2012-10-01 false Part 73 Index Alphabetical Index Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES RADIO BROADCAST SERVICES Incorporated Standards Incorporation by reference. Pt. 73, Index Alphabetical Index—Part 73 Rules Apply to All Services, AM, FM, and TV,...

  12. Urban versus Rural: Part-Time Enrollment

    ERIC Educational Resources Information Center

    Copeland, Michael; Tietjen-Smith, Tara; Waller, Lee Rusty; Waller, Sharon Kay

    2008-01-01

    The researchers examined part-time enrollment within public two-year, degree-granting community colleges by the degree of urbanization classifications of city, suburban, town, and rural for fall 2003 and 2005. Findings indicate no statistical differences in part-time enrollment between city and suburban institutions. No statistical differences…

  13. First Degrees by Part-Time Study.

    ERIC Educational Resources Information Center

    Styler, W. E.

    Degrees granted for part-time study are minimal in Britain and have been mainly awarded by London University. A small amount of part-time degree work is also carried on by Goldsmiths' College, West Ham College of Technology, and the Universities of Manchester, Durham, and Belfast. The establishment of the National Council for Academic Awards has…

  14. 31 CFR Appendix to Part 346 - Tables

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Tables Appendix to Part 346 Money and Finance: Treasury Regulations Relating to Money and Finance (Continued) FISCAL SERVICE, DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING UNITED STATES INDIVIDUAL RETIREMENT BONDS Pt. 346, App. Appendix to Part...

  15. 49 CFR Appendix - Figures to Part 38

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 1 2010-10-01 2010-10-01 false Figures to Part 38 Transportation Office of the Secretary of Transportation AMERICANS WITH DISABILITIES ACT (ADA) ACCESSIBILITY SPECIFICATIONS FOR TRANSPORTATION VEHICLES Other Vehicles and Systems Trams, and similar vehicles, and systems Pt. 38, Figures Figures to Part 38 ER28SE98.000...

  16. 49 CFR Appendix - Figures to Part 38

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 1 2011-10-01 2011-10-01 false Figures to Part 38 Transportation Office of the Secretary of Transportation AMERICANS WITH DISABILITIES ACT (ADA) ACCESSIBILITY SPECIFICATIONS FOR TRANSPORTATION VEHICLES Other Vehicles and Systems Trams, and similar vehicles, and systems Pt. 38, Figures Figures to Part 38 ER28SE98.000...

  17. Introduction to Algebra (Part 2). Preliminary Edition.

    ERIC Educational Resources Information Center

    Haag, V. H.; And Others

    This is part two of a two-part SMSG algebra text for ninth-grade students. The text was written for those students whose mathematical talent is underdeveloped. Chapter topics include the real numbers, addition of real numbers, multiplication of real numbers, properties of order, and subtraction and division for real numbers. (MP)

  18. Core sampling system spare parts assessment

    SciTech Connect

    Walter, E.J.

    1995-04-04

    Soon, there will be 4 independent core sampling systems obtaining samples from the underground tanks. It is desirable that these systems be available for sampling during the next 2 years. This assessment was prepared to evaluate the adequacy of the spare parts identified for the core sampling system and to provide recommendations that may remediate overages or inadequacies of spare parts.

  19. Body Parts and Early-Learned Verbs

    ERIC Educational Resources Information Center

    Maouene, Josita; Hidaka, Shohei; Smith, Linda B.

    2008-01-01

    This article reports the structure of associations among 101 common verbs and body parts. The verbs are those typically learned by children learning English prior to 3 years of age. In a free association task, 50 adults were asked to provide the single body part that came to mind when they thought of each verb. Analyses reveal highly systematic…

  20. 47 CFR Alphabetical Index - Part 74

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Part 74 Index Alphabetical Index Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES EXPERIMENTAL RADIO.... Pt. 74, Index Alphabetical Index—Part 74 A Additional orders by FCC (All Services) 74.28...