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1

Recurrent cardiac myxoma in a 25 year old male: a DNA study  

PubMed Central

We present a 25 year old Caucasian male patient with multiple recurrences of cardiac myxomas after surgical removal of the original tumor. His mother was operated on for right ventricular myxoma. The genetic analyses disclosed an aneuploid DNA content by flow cytometry analysis. The familial form of the cardiac myxomas must be distinguished from Carney complex syndrome. A long- term echocardiographic follow up is recommended to patients and their first degree relatives with cardiac myxomas.

2013-01-01

2

Perinatal care for incarcerated patients: a 25-year-old woman pregnant in jail.  

PubMed

More than 6 million men and 1 million women are under US correctional control, be it jail, prison, probation, or parole. On any given day, about 250,000 women and adolescent girls are behind bars, a number well in excess of those documented for all other sovereign nations. Moreover, women and girls represent the fastest-growing segment of the prison and jail populations. Approximately 75% of these women are mothers of minor children (leaving 200,000 children "motherless") and as many as 10,000 may be pregnant. Primarily designed for male offenders, the US correctional system is struggling to meet the specialized needs of its female inmates. Although incarceration during pregnancy is both stressful and dehumanizing, most studies paradoxically document better outcomes for pregnancies managed behind bars than for women of similar socioeconomic status whose pregnancies are managed in the community. Using the case of Ms A as a springboard for discussion, the issues, benefits, and challenges of caring for an incarcerated pregnant woman are addressed, as is the importance of family planning services to those about to be released. PMID:21304069

Clarke, Jennifer G; Adashi, Eli Y

2011-02-08

3

Bilateral Optic Nerve Sheath Meningioma with Intracanalicular and Intracranial Component in a 25-year-old Saudi Patient  

PubMed Central

Bilateral optic nerve sheath meningioma is rare. A meningioma is a benign neoplastic lesion from meningothelial cells of the meninges. They usually involve the intracanalicular portion of the optic nerve but may extend into the optic canal and through it to occupy the intracranial space. We present a case of 25-year-old Saudi female with bilateral optic nerve sheath meningioma. The diagnosis was delayed more than six years from initial symptoms.

Badr, Maha A.; Elkhamary, Sahar M.; Al Sabbagh, Samira; Al Turjoman, Abdulsalam

2008-01-01

4

Radiation-induced Malignant Fibrous Histiocytoma of the Maxillary sinus in a 25-year-old patient with Nasopharyngeal Carcinoma: Early MR Imaging Characteristics  

Microsoft Academic Search

The early MR imaging characteristics of a malig - nant fibrous histiocytoma (MFH) in a 25-year-old man under the radiation treatment of nasopharyn - geal carcinoma were presented in this study. The tumor developed four years and 9 months following the 3-dimentional conformal radiotherapy of naso - pharyngeal carcinoma. Early magnetic resonance imaging features were nonspecific for neoplasm and not

Cheng-Yu Chen; Yi-Jen Peng

2006-01-01

5

Primary Cardiac Angiosarcoma in a 25-Year-Old Man  

PubMed Central

Primary cardiac tumors do not occur frequently, and only one quarter of them, chiefly sarcomas, are malignant. Patients with angiosarcoma typically have a shorter survival time than do patients with other sarcomas, and the prognosis for survival depends strictly on the stage of the disease at the time of diagnosis and the possibility of complete surgical excision. Chemotherapy and radiotherapy have well-established postoperative roles because of the high probability of metastasis. We report the case of a 25-year-old man who presented with pericardial effusion and echocardiographic evidence of an intracavitary right atrial mass but without the bulky, infiltrative growth typical of this location of the disease. Malignancy was suggested by the clinical presentation, the location of the mass in the right side of the heart, and the absence of conditions favoring thrombus formation. After complete surgical excision, the mass was confirmed to be an angiosarcoma. Conventional adjuvant chemotherapy and maintenance therapy with inhibitors of CD117 (c-kit) and vascular endothelial growth factor relieved the patient's clinical symptoms and enabled his long-term, disease-free survival. In addition to reporting this case, we discuss aspects of the diagnosis and treatment of angiosarcoma.

Bellitti, Renato; Buonocore, Marianna; De Rosa, Nicolina; Covino, Franco Enrico; Casale, Beniamino; Sante, Pasquale

2013-01-01

6

Uncorrected tetralogy of fallot in a 25-year old nigerian african.  

PubMed

Tetralogy of Fallot is the most common form of cyanotic congenital heart disease. Survival after the age of 12 years without corrective surgery is rare. We present the case of a 25 year-old man with uncorrected tetralogy of Fallot. Possible reasons for the longetivity in this patient are left ventricular hypertrophy and systemic to pulmonary shunting through internal mammary arteries. PMID:21769263

Ojji, Dike B; Babalola, Akinola O; Falase, Ayodele O

2011-04-27

7

Uncorrected Tetralogy of Fallot in a 25-Year Old Nigerian African  

PubMed Central

Tetralogy of Fallot is the most common form of cyanotic congenital heart disease. Survival after the age of 12 years without corrective surgery is rare. We present the case of a 25 year-old man with uncorrected tetralogy of Fallot. Possible reasons for the longetivity in this patient are left ventricular hypertrophy and systemic to pulmonary shunting through internal mammary arteries.

Ojji, Dike B.; Babalola, Akinola O.; Falase, Ayodele O.

2011-01-01

8

Ductal carcinoma in situ in a 25-year-old man presenting with apparent unilateral gynecomastia  

PubMed Central

Ductal carcinoma in situ (dcis) in a young man is rarely reported. Our patient, a 25-year-old man, presented with apparent symptomatic unilateral gynecomastia. He has a strong history of cancer on both the maternal and paternal sides of his family, including breast and lung (maternal) and melanoma, colon, and pancreatic (paternal). His mother tested negative for BRCA1 and BRCA2. There is no information on paternal genetic testing. The patient was treated with left subcutaneous mastectomy. Upon histologic review of the sample, concurrent gynecomastia and dcis were discovered. To date, only 4 cases of gynecomastia and dcis have been described in younger male patients. Because only 30%–50% of patients with dcis eventually develop invasive cancer in the subsequent 10–20 years, dcis prevalence in the general population may be higher than predicted. This case underscores the importance of family history in any patient presenting with a breast mass. Patients must be made aware of the risk, however small it may be, and physicians must remain cautious of cancer in young men with gynecomastia.

Coroneos, C.J.; Hamm, C.

2010-01-01

9

Ductal carcinoma in situ in a 25-year-old man presenting with apparent unilateral gynecomastia.  

PubMed

Ductal carcinoma in situ (DCIS) in a young man is rarely reported. Our patient, a 25-year-old man, presented with apparent symptomatic unilateral gynecomastia. He has a strong history of cancer on both the maternal and paternal sides of his family, including breast and lung (maternal) and melanoma, colon, and pancreatic (paternal). His mother tested negative for BRCA1 and BRCA2. There is no information on paternal genetic testing.The patient was treated with left subcutaneous mastectomy. Upon histologic review of the sample, concurrent gynecomastia and DCIS were discovered. To date, only 4 cases of gynecomastia and DCIS have been described in younger male patients. Because only 30%-50% of patients with DCIS eventually develop invasive cancer in the subsequent 10-20 years, DCIS prevalence in the general population may be higher than predicted. This case underscores the importance of family history in any patient presenting with a breast mass. Patients must be made aware of the risk, however small it may be, and physicians must remain cautious of cancer in young men with gynecomastia. PMID:20697526

Coroneos, C J; Hamm, C

2010-08-01

10

Radiographic Evaluation of Third Molar Development in 5- to 25 Year Olds in Tehran, Iran  

PubMed Central

Objective: Radiographic evaluation of the third molar tooth to determine its position and degree of development is an important part in diagnosis and treatment planning, as well as in forensic dentistry procedures. The objective was to investigate the developmental stages of third molars in relation to chronologic age, gender and location (maxillary/mandibular) in an Iranian population. Materials and Methods: The data were collected in departments of pediatric dentistry and orthodontics, Tehran Faculty of Dentistry and four private offices. Three calibrated observers visited the centers to examine panoramic radiographs and corresponded patients documents in each age cohort in the range of 5- to-25-years old. Data were analyzed by Generalized Estimating Equation (GEE) in the linear mode and exchangeable correlation structure. The significance level was defined as 0.05. Results: The mean age of emerging third molars’ follicle was 9.29±1.65 years. Early calcification was seen at the mean age of 10.28±1.66 years. The GEE model controlling for age, gender and tooth location (maxillary/mandibular) revealed that besides age (?=0.43, p<0.001), the tooth location had association with the developmental stage (?=0.11, p<0.001) so that maxillary teeth were prior in calcification stages, but no relationship between gender and developmental stages was seen (?=0.03, p=0.69). Conclusion: Maxillary teeth were ahead of mandibular teeth in calcification stages with no gender difference. The present study may provide a reference for oral surgeons, pediatric dentists and orthodontists practicing in Iran and may have implications for the neighboring countries especially those with Caucasian populations.

Jafari, A.; Mohebbi, SZ.; Khami, MR.; Shahabi, M. Shakur; Naseh, M.; Elhami, F.; Shamshiri, AR.

2012-01-01

11

Pathology Case Study: A 25-Year-Old Female with a Liver Mass  

NSDL National Science Digital Library

Eric Schubert, MD contributed this case to the online case studies collection at the University of Pittsburgh School of Medicine. In this case, images of a liver mass in a 25-year-old woman are presented for diagnosis. Students can use the gross and microscopic images and information provided to test their diagnostic skills. The official conclusion is provided in the "Final Diagnosis" section.

Schubert, Eric

2007-08-08

12

False-Belief Understanding in 2.5-Year-Olds: Evidence from Two Novel Verbal Spontaneous-Response Tasks  

ERIC Educational Resources Information Center

Recent research indicates that toddlers and infants succeed at various "non-verbal" spontaneous-response false-belief tasks; here we asked whether toddlers would also succeed at verbal spontaneous-response false-belief tasks that imposed significant linguistic demands. We tested 2.5-year-olds using two novel tasks: a "preferential-looking" task in…

Scott, Rose M.; He, Zijing; Baillargeon, Renee; Cummins, Denise

2012-01-01

13

A Survey of Vocational Training Needs of 15-25 Years Old Out-of-School Youths in Bauchi Metropolis  

ERIC Educational Resources Information Center

The main purpose of the study was to explore and describe the vocational training needs of 15-25 years old out-of-school youths in Bauchi Metropolis of Bauchi State, Nigeria. Specifically, the researchers sought to; describe their demographic characteristics, examine their vocational training needs, the influence of gender on the vocational needs,…

Bello, M. I.; Danjuma, I. M.; Adamu, A. Y.

2007-01-01

14

False-Belief Understanding in 2.5-Year-Olds: Evidence from Two Novel Verbal Spontaneous-Response Tasks  

ERIC Educational Resources Information Center

|Recent research indicates that toddlers and infants succeed at various "non-verbal" spontaneous-response false-belief tasks; here we asked whether toddlers would also succeed at verbal spontaneous-response false-belief tasks that imposed significant linguistic demands. We tested 2.5-year-olds using two novel tasks: a "preferential-looking" task…

Scott, Rose M.; He, Zijing; Baillargeon, Renee; Cummins, Denise

2012-01-01

15

A 25-year-old woman with a gastric GIST and a PET-positive epicardial tumor  

Microsoft Academic Search

Background A 25-year-old woman presented with a history of abdominal pain. Endoscopy of the upper gastrointestinal tract revealed a tumor that protruded into the prepyloric antrum. After resection, a 'high-risk' gastrointestinal stromal tumor was histologically confirmed.Investigations Endoscopy, endoscopic ultrasound, hemigastrectomy, [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET\\/CT scan, histological examination, immunohistochemistry, cardiac MRI, high-resolution CT with electrocardiogram gating, CT angiography, and cardiac surgery.Diagnosis Gastrointestinal stromal

Volker Kächele; Sandra Pauls; Felix M Mottaghy; Norbert Blumstein; Hans J Brambs; Thomas FE Barth; Andreas Hannekum; Martin Höher; Martin Jeltsch; Sven N Reske; Peter Möller; Guido Adler; Thomas Seufferlein

2007-01-01

16

Seroepidemiology of hepatitis E virus infection in 2-25-year-olds in Sari district, Islamic Republic of Iran  

Microsoft Academic Search

The seroprevalence of hepatitis E virus infection (HEV) in children and young adults was determined in a community-based survey in an area of northern Islamic Republic of Iran. Serum sam- ples were taken from 1080 randomly selected apparently healthy 2-25-year-olds from urban and rural regions of Sari district. Anti-HEV IgG antibodies were detected in 25 individuals (2.3%). Seroprevalence increased significantly

M. J. Saffar; R. Farhadi; A. Ajami; A. R. Khalilian; F. Babamahmodi; H. Saffar

17

A 25-year-old man with 50 teeth: Astonishing but true!!  

PubMed Central

Retained primary teeth is a well-known process but multiple retained primary, permanent, and supernumerary teeth that too in an asymptomatic, non-syndromic patient is a rare possibility that has rarely been reported in literature. This case report discusses the clinical and radiographic details along with treatment options in a 21-year-old patient having a total number of 50 teeth, i.e., 16 retained primary teeth, 32 permanent teeth, and 2 supernumerary teeth without being associated with any known syndrome complex or metabolic disorder.

Bhatia, Vishwas; Jain, Nitul; Bhatia, Garima; Garg, Rakesh

2013-01-01

18

Safety and Immunogenicity of Human Papillomavirus-16/18 AS04-Adjuvanted Vaccine: A Randomized Trial in 10-25-Year-Old HIV-Seronegative African Girls and Young Women  

PubMed Central

Background.?Cervical cancer is a major public health problem for women in sub-Saharan Africa. Availability of a human papillomavirus (HPV) vaccine could have an important public health impact. Methods.?In this phase IIIb, double-blind, randomized, placebo-controlled, multicenter trial (NCT00481767), healthy African girls and young women seronegative for human immunodeficiency virus (HIV) were stratified by age (10–14 or 15–25 years) and randomized (2:1) to receive either HPV-16/18 AS04-adjuvanted vaccine (n = 450) or placebo (n = 226) at 0, 1, and 6 months. The primary objective was to evaluate HPV-16/18 antibody responses at month 7. Seropositivity rates and corresponding geometric mean titers (GMTs) were measured by enzyme-linked immunosorbent assay. Results.?In the according-to-protocol analysis at month 7, 100% of initially seronegative participants in the vaccine group were seropositive for both anti–HPV-16 and anti–HPV-18 antibodies (n = 130 and n = 128 for 10–14-year-olds, respectively; n = 190 and n = 212 for 15–25-year-olds). GMTs for HPV-16 and HPV-18 were higher in 10–14-year-olds (18 423 [95% confidence interval, 16 185–20 970] and 6487 [5590–7529] enzyme-linked immunosorbent assay units (EU)/mL, respectively) than in 15–25-year-olds (10 683 [9567–11 930] and 3743 [3400–4120] EU/mL, respectively). Seropositivity was maintained at month 12. No participant withdrew owing to adverse events. No vaccine-related serious adverse events were reported. Conclusions.?The HPV-16/18 AS04-adjuvanted vaccine was highly immunogenic and had a clinically acceptable safety profile when administered to healthy HIV-seronegative African girls and young women.

Sow, Papa Salif; Watson-Jones, Deborah; Kiviat, Nancy; Changalucha, John; Mbaye, Khardiata Diallo; Brown, Joelle; Bousso, Kouro; Kavishe, Bazil; Andreasen, Aura; Toure, Macoumba; Kapiga, Saidi; Mayaud, Philippe; Hayes, Richard; Lebacq, Marie; Herazeh, Marjan; Thomas, Florence; Descamps, Dominique

2013-01-01

19

Knowledge and Attitudes about Suicide in 25-Year-Olds  

Microsoft Academic Search

Objective: To examine knowledge and attitudes about suicide in a New Zealand sample of young people aged 25 years.Method: The sample was a birth cohort of 1265 young people born in New Zealand in 1977 who have been followed in a longitudinal study for 25 years. At age 25, participants were asked a series of questions designed to assess their

Annette L. Beautrais; L. John Horwood; David M. Fergusson

2004-01-01

20

Genital self-mutilation in an attempt of suicide by a patient with a borderline personality.  

PubMed

Self-mutilation acts are known to characterize the borderline personality disorders. However, voluntary cutting of the male genital organ remains extremely rare. The present paper reports a case of a 25-years-old young male with a borderline personality. The patient committed a genital self-mutilation (GSM) targeting suicide during incarceration stage in jail. In addition, a discussion of the epidemiological and psychopathological aspects of the self-mutilation of borderline patients was been conducted. A particular interest is attributed to the genital self-mutilation and a review of the literature is presented. PMID:23914106

Aalouane, Rachid; Rammouz, Ismail; Hafidi, Hicham; Boujraf, Saïd

2013-04-01

21

Genital self-mutilation in an attempt of suicide by a patient with a borderline personality  

PubMed Central

Self-mutilation acts are known to characterize the borderline personality disorders. However, voluntary cutting of the male genital organ remains extremely rare. The present paper reports a case of a 25-years-old young male with a borderline personality. The patient committed a genital self-mutilation (GSM) targeting suicide during incarceration stage in jail. In addition, a discussion of the epidemiological and psychopathological aspects of the self-mutilation of borderline patients was been conducted. A particular interest is attributed to the genital self-mutilation and a review of the literature is presented.

Aalouane, Rachid; Rammouz, Ismail; Hafidi, Hicham; Boujraf, Said

2013-01-01

22

[A clinic analysis of 62 male patients with lupus nephritis].  

PubMed

To study the difference between male and female patients with lupus nephritis(LN), we made a retrospective analysis. The clinical characteristics of 62 male patients with LN were compared with 62 female patients with LN. The result indicated the distribution of LN onset ages was different between male and female patients with LN. The incidence of LN was higher in the male than in female patients with SLE. Male patients were often misdiagnosed or diagnosed long after the onset of the disease. Arthritis and positive rate of ANA were less commonly occurred in female patients with LN. Other clinical and pathologic features of LN were similar in male and female patients. The response to treatment and prognosis of male patients with LN was relatively poor. So male patients with LN should be paid more attention to. PMID:12903459

Li, H; Li, X; Chu, G; Liu, J; Bi, Z

2000-08-01

23

JAMA Patient Page: Male Sexual Dysfunction  

MedlinePLUS

... sexual dysfunction can be caused by physical or psychological problems. The June 23/30, 2004, issue of JAMA includes an article about the various types of male sexual dysfunction and treatments for them. ...

24

Lymph node metastasis in gastric cardiac adenocarcinoma in male patients  

PubMed Central

AIM: To reveal the clinicopathological features and risk factors for lymph node metastases in gastric cardiac adenocarcinoma of male patients. METHODS: We retrospective reviewed a total of 146 male and female patients with gastric cardiac adenocarcinoma who had undergone curative gastrectomy with lymphadenectomy in the Department of Surgery, Xin Hua Hospital and Rui Jin Hospital of Shanghai Jiaotong University Medical School between November 2001 and May 2012. Both the surgical procedure and extent of lymph node dissection were based on the recommendations of Japanese gastric cancer treatment guidelines. Univariate and multivariate analyses of lymph node metastases and the clinicopathological features were undertaken. RESULTS: The rate of lymph node metastases in male patients with gastric cardiac adenocarcinoma was 72.1%. Univariate analysis showed an obvious correlation between lymph node metastases and tumor size, gross appearance, differentiation, pathological tumor depth, and lymphatic invasion in male patients. Multivariate logistic regression analysis revealed that tumor differentiation and pathological tumor depth were the independent risk factors for lymph node metastases in male patients. There was an obvious relationship between lymph node metastases and tumor size, gross appearance, differentiation, pathological tumor depth, lymphatic invasion at pN1 and pN2, and nerve invasion at pN3 in male patients. There were no significant differences in clinicopathological features or lymph node metastases between female and male patients. CONCLUSION: Tumor differentiation and tumor depth were risk factors for lymph node metastases in male patients with gastric cardiac adenocarcinoma and should be considered when choosing surgery.

Ren, Gang; Chen, Ying-Wei; Cai, Rong; Zhang, Wen-Jie; Wu, Xiang-Ru; Jin, Ye-Ning

2013-01-01

25

Anterior hippocampal volume reduction in male patients with schizophrenia  

Microsoft Academic Search

Quantitative high resolution magnetic resonance imaging (MRI) was utilized to measure anterior, posterior, and total hippocampal volumes in 27 male patients with chronic schizophrenia and 24 male controls. To optimize measurement techniques, hippocampal volumes were: (1) acquired with 1.4-mm slices; (2) excluded with the amygdala; (3) normalized for position; and (4) corrected for total intracranial volume (ICV). The results of

Mary P Pegues; Linda J Rogers; Diane Amend; Sophia Vinogradov; Raymond F Deicken

2003-01-01

26

Sentinel lymph node biopsy in male breast cancer patients.  

PubMed

The concept of sentinel node biopsy has been validated for female breast cancer patients whereas, ALND remains the standard of care for male breast cancer patients with similar tumours. We evaluated the results of SLN biopsy in male breast cancer patients with clinically negative axillae. This study included all male breast cancer patients who underwent SLN biopsy between February 1998 and October 2003. All patients had negative axillae on clinical examination. All patients underwent pre-operative lymphoscintigraphy. SLN biopsy was performed using a combination of Patent blue V and 99mTc-radiolabelled colloidal albumin injected peritumourally. Nine patients, 26-79 years of age, were included in the study. Pre-operative lymphoscinitgraphy identified SLNs in all patients. Intraoperatively, SLNs were successfully localised in all patients. The mean number of SLNs encountered was 2.4. Five patients had a positive SLN, four a negative SLN. Five patients (one with a negative SLN, four with a positive SLN) had been elected pre-operatively to undergo ALND regardless of findings on SLN biopsy. ALND confirmed the SLN to be negative in one patient (false-negative rate: 0%) and three of the four patients with positive SLN(s) had additional positive nodes in the axilla. SLN biopsy accurately predicted axillary lymph node status in these five patients. These findings compare favourably with findings reported in the literature regarding SLN biopsy in female breast cancer patients. SLN biopsy accurately staged the axilla in male breast cancer patients and should be considered for axillary staging in male breast cancer patients with clinically negative axillae. PMID:15135473

Goyal, A; Horgan, K; Kissin, M; Yiangou, C; Sibbering, M; Lansdown, M; Newcombe, R G; Mansel, R E; Chetty, U; Ell, P; Fallowfield, L; Kissin, M

2004-06-01

27

Abnormal melatonin secretion in male patients with hypogonadism  

Microsoft Academic Search

Recently we have demonstrated that melatonin secretion is increased in untreated male patients with GnRH deficiency. Testosterone\\u000a administration to these patients decreased melatonin secretion to normal levels. These data, however, did not exclude a gonadotropic\\u000a effect on melatonin secretion.\\u000a \\u000a To further elucidate whether gonadal steroids and\\/or gonadotropins modulate melatonin secretion in humans we compared untreated\\u000a young males with hypogonadotropic hypogonadism

Rafael Luboshitzky; Oded Wagner; Schahar Lavi; Paula Herer; Peretz Lavie

1996-01-01

28

Hypogonadism in male cancer patients: A cross-sectional study  

Microsoft Academic Search

Introduction. Cancer is the second most common cause of death in the USA (2). Studies have shown a coexistence of cancer and hypogonadism (9,31,13). The majority of patients with cancer develop cachexia, which cannot be solely explained by anorexia seen in these patients. Testosterone is a male sex hormone which is known to increase muscle mass and strength, maintain cancellous

Bhavana Konda

2010-01-01

29

Desire for non-mutilative disability in a nonhomosexual, male-to-female transsexual.  

PubMed

In adults, the desire for a healthy limb amputation has been reported in both the lay press and the scientific literature. While the etiology of this condition is currently unknown, prevailing theories have tended to conceptualize the phenomenon as paraphilic in origin. In this report, we present the case of a 25-year-old, nonhomosexual male-to-female transsexual who manifested an intense desire to be afflicted with a nonmutilative neurological disability (multiple sclerosis). The patient categorically denied sexual attraction towards the thought of being an amputee or physically disabled. Hypotheses are proposed for the development of this condition with special emphasis accorded to the significance of the preferred target disability. PMID:19387814

Kolla, Nathan J; Zucker, Kenneth J

2009-04-22

30

Management of neurogenic voiding dysfunction in the male patient  

Microsoft Academic Search

Management of neurogenic bladder in the male patient centers on identifying the optimal way to manage the lower urinary tract\\u000a for the individual patient. Factors in this decision include intravesical detrusor storage pressures (and protection of the\\u000a upper urinary tracts), upper extremity function and ability to perform intermittent catheterization, and patient preference\\u000a when choosing between options such as intermittent catheterization

David A. Ginsberg

2007-01-01

31

Impulsivity, Aggression and Suicide Risk among Male Schizophrenia Patients  

Microsoft Academic Search

Introduction: Impulsivity has been shown to be a major variable in the etiology of suicide and aggression, but has not been researched as much in the schizophrenic population, which is characterized by serious suicide and aggression risks. Methods: 68 male schizophrenia patients responded to a battery of measures including the Positive and Negative Syndrome Scale (PANSS), the impulsivity control scale

Iulian Iancu; Ehud Bodner; Suzana Roitman; Anna Piccone Sapir; Amir Poreh; Moshe Kotler

2010-01-01

32

Serum cholesterol and aggression in hospitalized male forensic patients  

Microsoft Academic Search

Human studies of the link between serum cholesterol and aggression have yielded equivocal results. Depending on the type of aggression studied (e. g., criminal violence or Type A hostility), investigators have found either a negative or a positive association between cholesterol and aggressive behavior. We conducted a retrospective analysis of aggressive incidents in a sample of hospitalized male forensic patients.

Marc Hillbrand; Reuben T. Spitz; Hilliard G. Foster

1995-01-01

33

Body Image Dissatisfaction in Male Cosmetic Surgery Patients  

Microsoft Academic Search

.   This study was the first empirical investigation of body image dissatisfaction in male cosmetic surgery patients. Thirty\\u000a men completed two body image measures prior to their initial consultation. Results were compared to the norms for each of\\u000a the measures and with a sample of 30 women seeking similar cosmetic procedures. Results indicated that patients did not demonstrate\\u000a greater dissatisfaction

Michael J. Pertschuk; David B. Sarwer; Thomas A. Wadden; Linton A. Whitaker

1998-01-01

34

Evaluation of vascular reactivity of young male hypogonadotrophic hypogonadism patients.  

PubMed

We aimed to study the vascular reactivity of young male hypogonadal hypogonadism patients without any cardiovascular risk factors and compare these findings with the ones of age-matched healthy controls. Study population consisted of 26 young male hypogonadotrophic hypogonadism patients (20.9 +/- 1.3 years) and 25 age-matched healthy male controls (21.8 +/- 2.9 years, P = NS). In addition to detailed hormonal analysis, each subject underwent ultrasound study of right brachial artery. Vessel diameter was measured at rest, during reactive hyperemia [endothelium-dependent flow-mediated vasodilation (FMD)] and after sublingual nitroglycerin administration (endothelium-independent vasodilation). Both flow-mediated and endothelium-independent sublingual nitroglycerin mediated dilatation values of patients were higher compared to controls (12.98 +/- 10.76% vs. 7.92 +/- 1.96%, P = 0.003 and 21.44 +/- 10.36% vs. 14.72 +/- 3.57%, P = 0.023, respectively). Linear regression analysis revealed that only serum HDL levels (relative risk 2.94, 95% CI 0.12-0.66, P = 0.006) and baseline vessel diameter (relative risk -2.77, 95% CI -17.73 to -2.70, P = 0.009) were found to be independently associated with FMD values. Endogenous male sex hormones seem to exert negative effects on vascular reactivity parameters and much of their effects are indirect that is by the way of alteration on lipid profile. PMID:19757149

Deniz, Ferhat; Ermi?, Necip; Kepez, Alper; Türk, Bari?; Akkoyunlu, Murat; Kara, Batuhan; Kutlu, Mustafa

2009-09-12

35

Fertility preservation strategies for male patients with cancer.  

PubMed

With the increasing number of patients surviving cancer, there is increasing interest in long-term quality of life, especially with respect to cancer-related infertility. Although infertility most commonly occurs as the result of treatment with gonadotoxic agents, it can also manifest before treatment has commenced. Current fertility preservation strategies for the postpubertal male patient with cancer focus on sperm cryopreservation before therapy. Sperm acquisition techniques should be discussed with the patient as early as possible, by either an oncologist or a specialist in male reproduction. For patients rendered infertile by cancer treatment who did not cryopreserve sperm beforehand, there are no techniques currently available to restore fertility. For the prepubertal male patient, cryopreservation of sperm is impossible. However, emerging research--primarily in animal models--into promising fertility preservation and restoration strategies might provide a clinical solution in the future. Advances in the protection and cryopreservation of spermatogonial stem cells (SSCs) might translate into clinical options for fertility preservation before treatment. Restoring fertility after treatment might also be possible via SSC autotransplantation or in vitro maturation of SSCs. Before any of these techniques become clinically viable, a number of scientific, logistical and ethical issues will need to be resolved. PMID:23835578

Katz, Darren J; Kolon, Thomas F; Feldman, Darren R; Mulhall, John P

2013-07-09

36

[Prolactinoma in the male. Preoperative evaluation of 40 patients].  

PubMed

Forty male patients with a prolactinoma were studied. The majority of tumors were large. Eight (20%) were microadenomas. Loss of libido and sexual impotence, the most frequent symptoms, were found in 82,5% of cases. Gynecomastia with galactorrhea was noted in six cases. Seven patients had hypopituitarism and nine visual field defects. Prolactin levels ranged from 30 to 7,000 ng/ml. The mean baseline prolactin value was higher in the group of invasive adenomas or enclosed adenomas with a suprasellar expansion. The LH-RH test, performed on twenty-eight patients, showed an abnormal response in 80% of the cases. PMID:7279098

Somma, M; Beauregard, H; Rasio, E

1981-01-01

37

Investigation of Cigarette Smoking among Male Schizophrenia Patients.  

PubMed

Male schizophrenia patients are known to have a heavier smoking pattern compared with the general population. However, the mechanism for this association is not known, though hypothesis that smoking could alleviate symptomatology of schizophrenia and reduce side effects of antipsychotics has been suggested. The aims of this study were to validate the heavier smoking pattern among male schizophrenia patients and to investigate the possible mechanisms for the association. To enhance the reliability of the study, we recruited two large independent samples with 604 and 535 male Chinese schizophrenia patients, and compared their smoking pattern with that of 535 healthy male controls recruited from general population. Validated multiple indicators and multiple causes structure equation model and regression models were used to investigate the association of smoking with factors of schizophrenia symptomatology and with the usage of antipsychotics and their extra-pyramidal side effects (EPS). Schizophrenia patients had significantly heavier smoking pattern compared with healthy controls in our sample (42.4% vs. 16.8%, p<0.001 for current smoking prevalence; 23.5% vs. 43.3%, p<0.001 for smoking cessation rate; 24.5% vs. 3.0%, p<0.001 for heavy smoker proportion). Their smoking status was also found to be consistently and significantly associated with reduced negative factor scores for schizophrenia symptomatology (??=?-0.123, p?=?0.051 for sample-A; ??=?-0.103, p?=?0.035 for sample-B; ??=?-0.082, p?=?0.017 for the combined sample). However, no significant association was found between smoking and antipsychotics usage or risk of EPS. These results support that smoking is associated with improved negative symptoms, which could account for the heavier smoking pattern among schizophrenia patients. PMID:23977021

Jiang, Jundong; See, Yuen Mei; Subramaniam, Mythily; Lee, Jimmy

2013-08-15

38

[Gonad function and sexual activity in male renal transplant patients].  

PubMed

Gonad function and sexual activity were evaluated in 44 young male adults who received a kidney shortly before or during adolescence. All patients were growth-retarded (-2.2 SD). Volume of the testes was decreased less than 12 ml, i.e, less than 10th centile) in 47% of patients, whereas hormone levels (testosterone, FSH, LH, and prolactin) were within the normal range. Oligospermia or azoospermia was found in 10 of 11 tested patients. Testicular function and sperm count were negatively correlated with renal function. Age at first ejaculation was increased and 57% of patients had never had sexual intercourse, although all patients reported normal sexual drive and normal erections. PMID:1929106

Kassmann, K; Arsan, A; Sharer, K; Broyer, M

1991-06-01

39

Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients  

PubMed Central

Background The hippocampus has been shown to be abnormal in schizophrenia. The fornix is one of the main fiber tracts connecting the hippocampus with other brain regions. Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia. Methods Line-scan diffusion tensor imaging (DTI) was used to evaluate diffusion in the fornix in 24 male patients with chronic schizophrenia and 31 male control subjects. Maps of fractional anisotropy (FA) and mean diffusivity (Dm), which are indices sensitive to white-matter integrity, were generated to quantify diffusion within the fornix. We used high spatial resolution magnetic resonance imaging (MRI) to measure hippocampal volume. Results FA and cross-sectional area of the fornix were significantly reduced in patients compared with control subjects. Dm was significantly increased, whereas hippocampal volume was bilaterally reduced in patients. Reduced hippocampal volume was correlated with increased mean Dm and reduced cross-sectional area of the fornix for patients. Patients also showed a significant correlation between reduced scores on neuropsychologic measures of declarative-episodic memory and reduced hippocampal volumes. Conclusions These findings demonstrate a disruption in fornix integrity in patients with schizophrenia.

Kuroki, Noriomi; Kubicki, Marek; Nestor, Paul G.; Salisbury, Dean F.; Park, Hae-Jeong; Levitt, James J.; Woolston, Sophie; Frumin, Melissa; Niznikiewicz, Margaret; Westin, Carl-Fredrik; Maier, Stephan E.; McCarley, Robert W.; Shenton, Martha E.

2009-01-01

40

[Snake charmer NOTES-proctocolectomy in a male patient].  

PubMed

Restricted ability of triangulation, a highly flexible intestine, as well as limited control and overview over the abdominal organs, complicated extensive abdominal interventions in the past. Thus, additional access sites were needed to allow sufficient interoperative control. The newly developed snake charmer NOTES-technique enables the reduction of accesses to the umbilicus and rectum. We report the first case of total proctocolectomy with ileoanal pouch formation in hybrid NOTES technique in a male patient. PMID:21626420

Lamadé, W; Schymik, K; Rieber, F; Friedrich, C; Etzrodt, J; Ulmer, C; Thon, K P

2011-08-01

41

Sperm counts and sperm sex ratio in male infertility patients.  

PubMed

In recent years, investigators have noted a trend toward a declining proportion of male births in many industrialized nations. While men bear the sex-determining chromosome, the role of the female partner as it pertains to fertilization or miscarriage may also alter the gender ratio. We attempted to determine a man's secondary sex ratio (F1 generation) by directly examining the sex chromosomes of his sperm. We examined our male infertility clinic database for all men who had undergone a semen fluorescence in situ hybridization (FISH). Patient demographic and semen parameters were recorded. Chi-squared analysis was used to compare gender ratios (Y chromosomes/total chromosomes). Multivariable logistic regression was used to predict the odds of possessing a Y-bearing sperm after accounting for demographic and semen parameters. A total of 185 men underwent sperm FISH. For the entire cohort, the proportion of Y chromosome-bearing sperm was 51.5%. Men with less than five million motile sperm had a significantly lower proportion of Y chromosome-bearing sperm (50.8%) compared to men with higher sperm counts (51.6%; P=0.02). After multivariable adjustment, a higher sperm concentration, total motile sperm count and semen volume significantly increased the odds of having a Y chromosome-bearing sperm (P<0.01). As a man's sperm production declines, so does the proportion of Y chromosome-bearing sperm. Thus, a man's reproductive potential may predict his ability to sire male offspring. PMID:22842703

Eisenberg, Michael L; Murthy, Lata; Hwang, Kathleen; Lamb, Dolores J; Lipshultz, Larry I

2012-07-30

42

Sperm counts and sperm sex ratio in male infertility patients  

PubMed Central

In recent years, investigators have noted a trend toward a declining proportion of male births in many industrialized nations. While men bear the sex-determining chromosome, the role of the female partner as it pertains to fertilization or miscarriage may also alter the gender ratio. We attempted to determine a man's secondary sex ratio (F1 generation) by directly examining the sex chromosomes of his sperm. We examined our male infertility clinic database for all men who had undergone a semen fluorescence in situ hybridization (FISH). Patient demographic and semen parameters were recorded. Chi-squared analysis was used to compare gender ratios (Y chromosomes/total chromosomes). Multivariable logistic regression was used to predict the odds of possessing a Y-bearing sperm after accounting for demographic and semen parameters. A total of 185 men underwent sperm FISH. For the entire cohort, the proportion of Y chromosome-bearing sperm was 51.5%. Men with less than five million motile sperm had a significantly lower proportion of Y chromosome-bearing sperm (50.8%) compared to men with higher sperm counts (51.6% P=0.02). After multivariable adjustment, a higher sperm concentration, total motile sperm count and semen volume significantly increased the odds of having a Y chromosome-bearing sperm (P<0.01). As a man's sperm production declines, so does the proportion of Y chromosome-bearing sperm. Thus, a man's reproductive potential may predict his ability to sire male offspring.

Eisenberg, Michael L; Murthy, Lata; Hwang, Kathleen; Lamb, Dolores J; Lipshultz, Larry I

2012-01-01

43

Mastication and prescribed fire impacts on fuels in a 25-year old ...  

Treesearch

Description: Due to increases in tree density and hazardous fuel loading in Sierra ... tree data collection, bulk density samples were gathered for masticated material. ... Masticated treatment in conjunction with prescribed burning reduced both ...

44

Socioeconomic differences in patterns of health and oral health behaviour in 25 year old Norwegians  

Microsoft Academic Search

The purpose of this study was to test the hypothesis of multidimensionality of oral and general health behaviour. To evaluate the proposed behavioural dimensions, relationships with individual beliefs and socio-economic factors were explored. A simple random sample of 1190 residents born in 1972 was drawn from the populations of three counties in western Norway in February 1997. A questionnaire was

A. Åstrøm; J. Rise

2001-01-01

45

High-Risk Health and Credit Behavior among 18- to 25-Year-Old College Students  

ERIC Educational Resources Information Center

|The number of students accumulating credit card debt--and the amount of debt itself--on college campuses is increasing. If high-risk credit and health behavior are associated, health behavior interventions might apply to high-risk credit behavior. Objective: The authors' purpose was to examine these possible associations. Participants and…

Adams, Troy; Moore, Monique

2007-01-01

46

High-Risk Health and Credit Behavior Among 18- to 25YearOld College Students  

Microsoft Academic Search

The number of students accumulating credit card debt—and the amount of debt itself—on college campuses is increasing. If high-risk credit and health behavior are associated, health behavior interventions might apply to high-risk credit behavior. Objective: The authors' purpose was to examine these possible associations. Participants and Methods: They used a retrospective design with existing data from a sample of 45,213

Troy Adams; Monique Moore

2007-01-01

47

High isoflavone content and estrogenic activity of 25 year-old Glycine max tissue cultures.  

PubMed

Soy isoflavones are phytoestrogens which have been associated with several health benefits. In the present study, we report the production of isoflavones in a collection of 40 strains of soya cell cultures established in 1975. A large variability in the isoflavone composition was observed and high-producing strains, with an isoflavone content of up to 46.3 mg g(-1) dry wt., were found. In comparison with soybeans, many callus strains had a higher isoflavone concentration (10-40 times) and a different ratio of genistin to daidzin forms. The highest producing strain was transferred to liquid medium in an Erlenmeyer flask and in a 10 l stirred-tank bioreactor where high isoflavone content (7% dry wt.), concentration (880 mg l(-1)) and a maximum productivity estimated to 60 mg l(-1) d(-1) were obtained. We further studied the estrogenic activity of pure compounds compared to plant cell culture extracts in the estrogen-responsive human endometrial Ishikawa cell line. Estrogen was confirmed to be 1000-10,000 times more active than isoflavones. The estrogenic activity of the extracts correlated to their isoflavone content. The activity of the malonyl isoflavones, assessed here for the first time, was lower than the aglycones. Taken together, these results suggest that soya cell cultures can be used as an alternative source to soybeans to provide high concentrations of bioactive isoflavones. PMID:13679094

Federici, Ermanno; Touché, André; Choquart, Sandie; Avanti, Ornella; Fay, Laurent; Offord, Elizabeth; Courtois, Didier

2003-10-01

48

Educational Attainment of 25 Year Old Norwegians According to Birth Order and Gender  

ERIC Educational Resources Information Center

This register-based longitudinal study of 392 969 Norwegians examined associations between birth order, gender and educational attainment at age 25 years within families (fixed effects regression) and between families (ordinary OLS regression). Data were retrieved from national registers for births of mothers with single births only and a first…

Kristensen, Petter; Bjerkedal, Tor

2010-01-01

49

Reduced Concentrations of Thalamic N-Acetylaspartate in Male Patients With Schizophrenia  

Microsoft Academic Search

Objective: The authors measured N-acetylaspartate (a putative neuronal marker) in the right and left thalamus of 17 male patients with schizophrenia using in vivo proton magnetic resonance spectroscopic imaging ( 1 H MRSI). Method: 1 H MRSI was performed on 17 medicated male patients with schizophrenia and 10 male comparison subjects. Concentra- tions of N-acetylaspartate, creatine, and choline were determined

Raymond F. Deicken; Camilla Johnson; Yael Eliaz; Norbert Schuff

2000-01-01

50

Correlates of violent assault among young male primary care patients.  

PubMed

Correlates of violent assault (defined here as having been shot, stabbed, shot at, or beaten) were identified among young male primary care patients. Data were analyzed from a cohort of young men ages 17 to 29 during their initial visits to an urban primary care facility. Each underwent a clinical assessment, including a self-report health inventory and provider history. In multivariable analysis, history of incarceration (odds ratio [OR] = 6.29, 95 percent confidence interval [CI], 2.34-16.89), having children (OR = 3.06, 95 percent CI, 1.30-7.17), and a high school education or less (OR = 0.69, 95 percent CI, 0.50-0.96) were significantly associated with increased likelihood of violent assault. Patients reporting more serious traumatic experiences, such as incarceration, witnessing violence, or carrying a weapon, had the highest risk (OR = 9.91, 95 percent CI, 4.0-24.57). These findings may help primary care physicians identify young men at risk for violence and foster better interventions. PMID:11217223

Rich, J A; Sullivan, L M

2001-02-01

51

Y Chromosome gene expression in the blood of male ischemic stroke patients compared to male controls  

PubMed Central

Background and Purpose Gender is suggested to be an important determinant of ischemic stroke risk factors, etiology and outcome. However, the basis for this remains unclear. The Y chromosome is unique in males. Genes expressed in men on the Y chromosome that are associated with stroke may be important genetic contributors to the unique features of males with ischemic stroke, which would be helpful for explaining sex differences observed between men and women. Methods Blood samples were obtained from 40 males at ? 3, 5 and 24 hours following ischemic stroke and from 41 male controls (July 2003- April 2007). RNA was isolated from blood and processed on Affymetrix Human U133 Plus 2.0 Arrays. Y chromosome genes differentially expressed between male stroke and male control subjects were identified using an analysis of covariance (ANCOVA) adjusted for age and batch. A p<0.05 and fold change (FC) > ?1.2? were considered significant. Results Seven genes on the Y chromosome were differentially expressed in males with ischemic strokes compared to controls. Five of these genes (VAMP7, CSF2RA, SPRY3, DHRSX, PLCXD1,) are located on pseudoautosomal regions (PARs) of the human Y chromosome. The other two genes (EIF1AY and DDX3Y) are located on the non-recombining region of the human Y chromosome (NRY). The identified genes were associated with immunology, RNA metabolism, vesicle fusion and angiogenesis. Conclusions Specific genes on the Y chromosome are differentially expressed in blood following ischemic stroke. These genes provide insight into potential molecular contributors to sex differences in ischemic stroke.

Tian, Yingfang; Stamova, Boryana; Jickling, Glen C; Xu, Huichun; Liu, Dazhi; Ander, Bradley P; Bushnell, Cheryl; Zhan, Xinhua; Turner, Renee J; Davis, Ryan R; Verro, Piero; Pevec, William C.; Hedayati, Nasim; Dawson, David L.; Khoury, Jane; Jauch, Edward C; Pancioli, Arthur; Broderick, Joseph P; Sharp, Frank R

2012-01-01

52

Clinicopathological Features of Female Gastric Carcinoma Patients with Curative Resection: Comparison with Male Patients  

PubMed Central

Little is known about the clinicopathological features of female gastric carcinoma (FGC) patients. We compared the clinicopathologic features and outcomes of FGC patients with curative resection with those of male gastric carcinoma (MGC) patients. We reviewed the hospital records of 940 FGC patients between 1986 and 2005 at Chonnam National University Hospital. Multivariate analysis showed that presence of serosal invasion, lymph node metastasis, and operative type were significant prognostic factors for survival of FGC patients with curative resection. Furthermore, the overall 5-year survival rate of FGC patients with curative resection (53.4%) was higher than that of MGC patients (47.6%, p<0.05). In advanced cases, no significant difference was observed in the overall 5-year survival rate between the FGC and MGC patients (41.6% vs 37.4%, p>0.05). Therefore, serosal invasion, lymph node metastasis, and type of operation were statistically significant parameters associated with survival. Early detection is more important for improving the prognosis of female patients with gastric cancer than for male patients.

Kim, Ho Goon; Ghu, Hoi Dong; Yun, Sang Kwon; Ryu, Seong Yeob

2012-01-01

53

Clinicopathological features of female gastric carcinoma patients with curative resection: comparison with male patients.  

PubMed

Little is known about the clinicopathological features of female gastric carcinoma (FGC) patients. We compared the clinicopathologic features and outcomes of FGC patients with curative resection with those of male gastric carcinoma (MGC) patients. We reviewed the hospital records of 940 FGC patients between 1986 and 2005 at Chonnam National University Hospital. Multivariate analysis showed that presence of serosal invasion, lymph node metastasis, and operative type were significant prognostic factors for survival of FGC patients with curative resection. Furthermore, the overall 5-year survival rate of FGC patients with curative resection (53.4%) was higher than that of MGC patients (47.6%, p<0.05). In advanced cases, no significant difference was observed in the overall 5-year survival rate between the FGC and MGC patients (41.6% vs 37.4%, p>0.05). Therefore, serosal invasion, lymph node metastasis, and type of operation were statistically significant parameters associated with survival. Early detection is more important for improving the prognosis of female patients with gastric cancer than for male patients. PMID:22977748

Kim, Ho Goon; Ghu, Hoi Dong; Yun, Sang Kwon; Ryu, Seong Yeob; Kim, Dong Yi

2012-08-24

54

The male cosmetic surgery patient: a matched sample gender analysis of elective cosmetic surgery and cosmetic dentistry patients.  

PubMed

Plastic surgeons have traditionally perceived male patients as more psychologically disturbed than female patients. This study employed a matched sample design to explore the psychosocial experiences of 50 male and 50 female elective cosmetic surgery and cosmetic dentistry patients. It also aimed to compare male and female patients on preoperative psychosocial dysfunction on standardized measures (psychiatric disturbance, anxiety, depression, low self-esteem, dysmorphic concern, and low body image) and postoperative dissatisfaction. The findings revealed that there were many similarities between the self-reported appearance concerns, motivations for surgery, and expectations of surgery between male and female patients. Although male patients did not report higher levels of preoperative psychosocial dysfunction than their female counterparts, they were more likely to report postoperative dissatisfaction. Preoperative screening is recommended to identify the minority of male patients who will report an unsatisfactory outcome despite a technically good result. PMID:20489400

Dowling, Nicki A; Honigman, Roberta J; Jackson, Alun C

2010-06-01

55

The Validity of Male Patients' Self-Reports Regarding Prostate Cancer Screening  

Microsoft Academic Search

Background.Despite the high rate of prostate cancer screening, the accuracy of male patients' self-reports of screening has not been investigated. This study assessed the concordance between patients' self-reports of prostate screening and the medical record.Methods.Focus groups were conducted to obtain male patients' perceptions of prostate cancer screening and salient terminology. A sample of males (n= 276), 40 years of age

Timothy R. Jordan; James H. Price; Keith A. King; Tatiana Masyk; Archie W. Bedell

1999-01-01

56

Zinc and copper-related blood parameters in male trauma patients  

Microsoft Academic Search

Physiologic stress depresses plasma zinc and elevates plasma copper, but effects on other zinc and copper related parameters are largely unknown. Therefore, several such parameters were investigated in 19 young, adult male trauma patients. Patients were studied 1 and 7 days after admission and compared to 21 aged matched male controls. At day 1, plasma zinc and zinc R-values (low

Hyojee Joung; Robert A. DiSilvestro; Jean C. Burge; Patricia S. Choban; Louis Flancbaum

1998-01-01

57

Incidence of prostate cancer in male breast cancer patients: a risk factor for prostate cancer screening  

Microsoft Academic Search

Synchronous or metachronous occurrences of both prostate cancer and male breast cancer are rarely reported, but provide insight into their hormonal and genetic biology. We sought to determine the incidence of prostate cancer in male breast cancer patients at our institution, and to examine estrogen receptor (ER), progesterone receptor (PR) and HER-2\\/neu receptor (HR) status in these patients. A retrospective

U J Lee; J S Jones

2009-01-01

58

Serum Leptin, Gonadotropin, and Testosterone Concentrations in Male Patients with Anorexia Nervosa during Weight Gain  

Microsoft Academic Search

Amenorrhea in female patients with anorexia nervosa is associated with low leptin secretion, thus suggesting a causal link. In an attempt to address the hypothesis that leptin also influences the hypothalamo- pituitary-gonadal function in males, we studied three male patients with acute anorexia nervosa longitudinally. Serum levels of leptin, LH, FSH, testosterone, and SHBG were measured on a biweekly basis

MARTIN WABITSCH; ANNE BALLAUFF; REINHARD HOLL; WERNER F. BLUM; EBERHARD HEINZE; HELMUT REMSCHMIDT; JOHANNES HEBEBRAND; Lilly Deutschland

59

Psychopathology and Dissociative Experiences of Male Taiwanese Patients with Gender Identity Disorder  

Microsoft Academic Search

Background: Gender identity disorder (GID) is a relatively rare disorder. Accordingly, only a small number of investigators have been researching this illness. The purpose of this study is to study general psychopathology and dissociative experiences of male patients with GID. Methods: We studied 18 male patients with DSM-IV-diagnosed GID who visited our outpatient clinic for compulsory military service screening. Eighteen

I-Shin Shiah; Szu-Nian Yang; Lih-Jong Shen; Ai-Ju Chang; Yuh-Cherng Gau; Yu-Jung Chen; Chih-Kang Chen

60

Support and coping of male hemodialysis-dependent patients  

Microsoft Academic Search

The purpose of this descriptive-correlational study was to describe coping strategies used by males with chronic renal failure who are dependent on hemodialysis; to describe their social networks; to describe the perceived support, conflict, and reciprocity within their interpersonal relationships; and to examine the relationships among the variables support, conflict, reciprocity, social networks, and coping strategies. Social support was conceptualized

Monique Cormier-Daigle; Miriam Stewart

1997-01-01

61

HIV providers' perceptions of and attitudes toward female versus male patients.  

PubMed

As a first step in understanding the role that health care providers may play in observed gender disparities in HIV care in the United States, we sought to examine whether HIV providers' perceptions of and attitudes toward female and male patients differ. We used data from the Enhancing Communication to Improve HIV Outcomes (ECHO) study, a multisite, cross-sectional study focused on the role of the patient-provider relationship in disparities in HIV care conducted from October 2006 to June 2007. Using separate scales, we assessed HIV providers' perceptions about their patients (e.g., intelligence, compliance, responsibility) as well as providers' attitudes toward their patients (e.g., like, respect, frustrate). We used multivariable linear regression with generalized estimating equations to compare provider scores for female and male patients. Our sample comprised 37 HIV providers and 317 patients. Compared with male patients, HIV-infected females were less likely to be highly educated or employed, and more likely to report nonadherence to antiretroviral medications and depressive symptoms. In unadjusted and adjusted analyses, there was a significant difference in providers' perceptions of female and male patients, with providers having more negative perceptions of female patients. However, there was no significant difference in HIV providers' attitudes toward female and male patients in unadjusted or adjusted analyses. Further study is needed to elucidate the role of providers' perceptions and attitudes about female and male patients in observed gender disparities in HIV care. PMID:22978375

Blackstock, Oni J; Beach, Mary Catherine; Korthuis, P Todd; Cohn, Jonathan A; Sharp, Victoria L; Moore, Richard D; Saha, Somnath

2012-09-14

62

HIV Providers' Perceptions of and Attitudes Toward Female Versus Male Patients  

PubMed Central

Abstract As a first step in understanding the role that health care providers may play in observed gender disparities in HIV care in the United States, we sought to examine whether HIV providers' perceptions of and attitudes toward female and male patients differ. We used data from the Enhancing Communication to Improve HIV Outcomes (ECHO) study, a multisite, cross-sectional study focused on the role of the patient–provider relationship in disparities in HIV care conducted from October 2006 to June 2007. Using separate scales, we assessed HIV providers' perceptions about their patients (e.g., intelligence, compliance, responsibility) as well as providers' attitudes toward their patients (e.g., like, respect, frustrate). We used multivariable linear regression with generalized estimating equations to compare provider scores for female and male patients. Our sample comprised 37 HIV providers and 317 patients. Compared with male patients, HIV-infected females were less likely to be highly educated or employed, and more likely to report nonadherence to antiretroviral medications and depressive symptoms. In unadjusted and adjusted analyses, there was a significant difference in providers' perceptions of female and male patients, with providers having more negative perceptions of female patients. However, there was no significant difference in HIV providers' attitudes toward female and male patients in unadjusted or adjusted analyses. Further study is needed to elucidate the role of providers' perceptions and attitudes about female and male patients in observed gender disparities in HIV care.

Beach, Mary Catherine; Korthuis, P. Todd; Cohn, Jonathan A.; Sharp, Victoria L.; Moore, Richard D.; Saha, Somnath

2012-01-01

63

Outcome analysis in patients with primary necrotizing fasciitis of the male genitalia  

Microsoft Academic Search

Objectives. To characterize patients with primary necrotizing fasciitis of the male genitalia (Fournier’s gangrene) and to identify risk factors and prognostic variables of survival.Methods. Fifty consecutive patients with primary necrotizing fasciitis of the male genitalia treated at our institution during a 15-year period between 1984 and 1998 were retrospectively analyzed. Of these patients, 44 (88.0%) were found to be eligible

Philipp Dahm; Frank H Roland; Steven N Vaslef; Richard E Moon; David T Price; Gregory S Georgiade; Johannes Vieweg

2000-01-01

64

Postural control in male patients with hip osteoarthritis  

Microsoft Academic Search

Earlier studies have demonstrated that postural control is worse in patients with knee osteoarthritis (OA) than in control subjects, whereas little information is available about the postural control in patients with hip OA. The aim of this study was to investigate the standing balance in different test conditions in men with hip OA and to compare the results with those

Jari P. A. Arokoski; Ville Leinonen; Merja H. Arokoski; Heikki Aalto; Hannu Valtonen

2006-01-01

65

Rapid Diagnosis of Chlamydia trachomatis in Male Patients by Antigen Detection in Urine Samples  

Microsoft Academic Search

To investigate the diagnostic value of testing urine samples as a rapid method for the detection of chlamydial antigen in males, first-catch urine (FCU) and urethral swab samples were obtained from 668 male patients and examined by an enzyme immunosorbent assay (ElA). Positive results were further analyzed by direct fluorescence antibody tests of the EIA sediment. Antigen detection was possible

A. Stary; C. Heller-Vitouch; I. Müller

1992-01-01

66

Erotic terror: Male patients’ horror of the early maternal erotic transference  

Microsoft Academic Search

There is a particular terror that many male patients experience and often flee from as they approach feelings associated with the early maternal erotic transference. While pre- oedipal regression stirs degrees of anxiety in all men (Tyson, 1982), the primal fear of intimacy experienced by schizoid males may provoke the terror of annihilation. In this paper, I will review and

Harriet Kimble Wrye

1993-01-01

67

Male breast cancer in patients with a familial history of breast cancer  

Microsoft Academic Search

We describe herein the clinical characteristics of five male breast carcinoma (MBC) patients with a familial history of breast carcinoma (FHBC). Four of these patients suffered from multiple primary cancers, being gastric and prostate cancer in 1, gastric cancer in 1, and asynchronous bilateral breast cancers in 2. The average age of these patients at diagnosis was not lower than

Sadako Akashi-Tanaka; Takashi Fukutomi; Atsuo Fukami; Takehiro Fujiki

1996-01-01

68

Axillary Metastasis as the First Manifestation of Occult Breast Cancer in a Male Patient  

Microsoft Academic Search

SummaryBackground: The aim of this study was to investigate the clinicopathologic features of male breast cancer. Case Report: We present the clinicopathologic data of a 72year-old male patient with occult breast cancer, who was diagnosed and underwent surgery in our hospital. The diagnosis was confirmed by histological examination, and the patient underwent modified radical mastectomy and axillary dissection. The histological

Guo-Li Gu; Shi-Lin Wang; Xue-Ming Wei; Li Ren; Fu-Xian Zou

2009-01-01

69

Male-to-Female Transsexualism: Technique, Results and 3Year Follow-Up in 50 Patients  

Microsoft Academic Search

Aim: To evaluate the functional and cosmetic results of male-to-female gender-transforming surgery. Patients and Methods: Between May 2001 and April 2008 we performed 50 male-to-female gender-transforming surgeries. All patients had been cross-dressing, living as women, and receiving estrogen and progesterone for at least 12 months, which was sufficient for breast development and atrophy of the testes and prostate to occur.

S. Wagner; F. Greco; M. R. Hoda; A. Inferrera; A. Lupo; A. Hamza; P. Fornara

2010-01-01

70

Apparent heterosexuality in two male patients requesting change-of-sex operation  

Microsoft Academic Search

Twenty-four male patients presenting with the request for change-of-sex surgery were studied. They were asked to estimate the strength of their sexual interest in men as compared with sexual interest in women. An independent and objective measure of sexual orientation was obtained by measuring penile volume responses to film sequences of male and female nudes. With two exceptions, the patients

R. F. Barr; B. Raphael; Norma Hennessey

1974-01-01

71

Testosterone concentrations and sirolimus in male renal transplant patients.  

PubMed

Sirolimus damages the testes in animals; however, human data are sparse. We conducted a case-control study to obtain further insight into this issue and compared testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and prolactin concentrations in matched renal transplant patients who did or did not receive sirolimus. We found that testosterone values were lower (11.2 +/- 6.3 nmol/L vs. 15.5 +/- 7.7 nmol/L, p < 0.05), in 28 sirolimus-treated patients, compared to 28 non-sirolimus-treated controls. Furthermore, these patients more commonly had testosterone concentrations that were below our reference value for normal men. In contrast, FSH and LH concentrations were higher while prolactin levels were not different. These data are consistent with sirolimus-related testosterone suppression and suggest a need for further studies. PMID:14678044

Fritsche, Lutz; Budde, Klemens; Dragun, Duska; Einecke, Gunilla; Diekmann, Fritz; Neumayer, Hans-Hellmut

2004-01-01

72

Palmar fasciitis and polyarthritis associated with ovarian carcinoma in a young patient a case report and review of the literature  

Microsoft Academic Search

Palmar fasciitis and polyarthritis (PFPA) is an uncommon syndrome characterized by progressive and extensive rheumatic disease. It has usually been associated with neoplasms, most commonly in elderly patients, preceding or accompanying the diagnosis of malignancy. We report a case of a 25-year-old patient with severe deforming PFPA preceding the diagnosis of carcinoma of the ovary. The histopathological findings of diffuse

S. Vinker; R. Dgani; B. Lifschitz-Mercer; Z. M. Sthoeger; L. Green

1996-01-01

73

A case of mosaic Goltz syndrome (focal dermal hypoplasia) in a male patient.  

PubMed

We present the case of a boy with a clinical diagnosis of Goltz (focal dermal hypoplasia) syndrome. This is a rare genodermatosis characterized by widespread dysplasia of mesodermal and ectodermal tissues. It is inherited in an X-linked dominant fashion and is normally lethal in male patients. Mutations in the PORCN gene (Xp11.23), the proteins of which are key regulators in embryonic development, have been found to be responsible for the syndrome. Sequencing of the PORCN gene was negative in our patient. This case highlights some of the challenges of obtaining a molecular diagnosis in male patients with suspected Goltz syndrome in the clinical setting. PMID:21332693

Lasocki, Anita L; Stark, Zornitza; Orchard, David

2011-02-01

74

Subtypes of Partner Violence Perpetrators Among Male and Female Psychiatric Patients  

Microsoft Academic Search

The goal of this naturalistic study was to examine heterogeneity among female and male civil psychiatric patients with a history of intimate partner violence (IPV) perpetration. Participants were 567 patients drawn from the MacArthur Violence Risk Assessment Study (J. Monahan et al., 2001). The authors examined subtype composition among 138 women and 93 men with positive histories of IPV and

Zach Walsh; Marc T. Swogger; Brian P. OConnor; Yael Chatav Schonbrun; M. Tracie Shea; Gregory L. Stuart

2010-01-01

75

A prospective series of musculoskeletal system rehabilitation of arthropathic joints in young male hemophilic patients  

Microsoft Academic Search

The study aims to evaluate prospective results of physical therapy interventions and rehabilitation of arthropathic joints\\u000a in young male hemophilic patients. Given that the effectiveness of the therapy would be higher if therapy is provided at early\\u000a ages, a series of males aged 18 years or younger were included in the study.The study is a descriptive case series of 31 hemophilic

Eda Gurcay; Emel Eksioglu; Ustun Ezer; Banu Cakir; Aytul Cakci

2008-01-01

76

Ultrasound Measurements at the Proximal Phalanges in Male Patients with Psoriatic Arthritis  

Microsoft Academic Search

:   Bone ultrasound parameters at the proximal phalanges of the hands were measured in 55 male patients with psoriatic arthritis\\u000a (PA) (39 with peripheral radiologic involvement and 16 with axial involvement), comparing the findings with those in 16 rheumatoid\\u000a arthritis (RA) patients, 20 ankylosing spondylitis (AS) patients and 55 age- and sex-matched normal controls. Mean values\\u000a of amplitude-dependent speed of

E. Taccari; F. Sensi; A. Spadaro; V. Riccieri; T. Rinaldi

2001-01-01

77

Patient satisfaction of female and male users of veterans health administration services  

Microsoft Academic Search

OBJECTIVE: To compare patient satisfaction of male and female users of Veterans Health Administration (VHA) services.\\u000a \\u000a \\u000a DESIGN: Cross-sectional study based on secondary analysis of data from VHA’s Survey of Healthcare Experiences of Patients (SHEP).\\u000a \\u000a \\u000a \\u000a \\u000a PATIENTS: National random sample of 107,995 outpatients and 112,817 inpatients in FY2004.\\u000a \\u000a \\u000a \\u000a \\u000a MEASURES: Patient’s ratings of overall quality (OQ) and unique dimensions of satisfaction. Sociodemographic and

Steven M. Wright; Thomas Craig; Stacey Campbell; Jim Schaefer; Charles Humble

2006-01-01

78

Alpha-galactosidase A activity levels in Turkish male hemodialysis patients.  

PubMed

Fabry disease is an X-linked lysosomal storage disorder due to deficient activity of alpha-galactosidase A (?-Gal A) leading to renal insufficiency in males. The aim of present study was to investigate the level of ?-Gal A activity and to determine the prevalence of Fabry disease in a Turkish male hemodialysis population. The activity of plasma ?-Gal A was measured in a group of 808 male hemodialysis patients using fluorimetric methods. Patients with low ?-Gal A activity were evaluated clinically and genetic testing was carried out. A correlation with creatinine, uric acid, urea, white blood cell (WBC), and high sensitivity (hs)CRP and ?-Gal A activity was also investigated. Plasma ?-Gal A activity among this male population undergoing hemodialysis was 7.88 ± 5.18 µM/hour/L (0.40-55.72), significantly lower when compared to controls. No influence of creatinine, uric acid, WBC, or hsCRP on measured ?-Gal A activity was reported. Two new Fabry disease patients were identified. Both were previously diagnosed with diabetes mellitus type 2. These findings provide, for the first time, data regarding the prevalence of ?-Gal A deficiency (0.24%) in Turkish males receiving hemodialysis. PMID:23190516

Kalkan Uçar, Sema; Sozmen, Eser; Duman, Soner; Ba?çi, Ali; Çoker, Mahmut

2012-08-13

79

The patient's motivation during bicycle stress ECG test is dependent on the investigator's sex in male patients.  

PubMed

The exercise electrocardiogram is a commonly used non-invasive method for detection of electrocardiogram (ECG) changes secondary to myocardial ischemia. Studies showed the importance of the patient's motivation to reach the estimated submaximal heart rate. The purpose of this study was to test whether the patient's motivation is dependent on the investigator's sex. We included 1170 patients (in-hospital patients and out-clinic patients; 63.5% male, 36.5% female) in this study. Stress test data (stationary bicycle with gradually increasing intensity) were collected retrospectively: patient's age, sex, maximal power stage, ECG-abnormalities, angina pectoris, and attending physician's sex. Male patients achieved a higher power stage than their female counterparts (126.5+/-47.7 W vs. 89.7+/-30.4 W). When male patients were supervised by a female doctor they reached higher maximum power stages (136.6+/-53.5 W vs. 121.6+/-43.3 W; p=0,001), more often the submaximal heart rate (47.9% vs. 38.3%; p=0.02) but complained less frequent about angina pectoris (5.6% vs. 17.3%). In contrast, none of these parameters was dependent on the attending physician's sex in female patients. The attending physician's sex influences the maximum exercise ability and the incidence of complaints during bicycle stress in male patients but not in females. We would speculate that men try to impress women with physical strength and try to dissimulate physical discomfort or pain. This could possibly influence the validity of such non-invasive methods with exercise dependent detection of myocardial ischemia. PMID:18597870

Jung, Christian; Ferrari, Markus; Goebel, Bjoern; Figulla, Hans R

2008-07-01

80

Primary retroperitoneal mucinous cystadenocarcinoma in a male patient: a case report  

PubMed Central

In the literature, 51 cases of primary retroperitoneal mucinous cystadenocarcinoma have been published. We report the fourth case occurring in a male patient. The 42-year-old patient presented with multiple retroperitoneal cystic masses causing abdominal discomfort without alteration of the global clinical state. The masses were totally removed by a two-stage surgery. No other treatment has been introduced. After a follow-up of 6 months, the patient is disease-free. This rare tumor most likely arises from the mucinous metaplasia of peritoneal inclusion cysts rather than from ectopic ovarian tissue or ovarian teratomas. The occurrence of such a tumor in a male patient supports this theory. Preoperative diagnosis is mostly difficult. Clinical behavior and treatment are still controversial.

Hrora, Abdelmalek; Jallal, Houda; Sabbah, Farid; Benamer, Abdessalam; Alaoui, Mouna; Raiss, Mohamed; Ahallat, Mohamed

2009-01-01

81

Effects of different calcineurin inhibitors on sex hormone levels in transplanted male patients.  

PubMed

Hormonal abnormalities in male patients with end-stage renal diseases are primarily organic and related to uremia as well as the other comorbid factors that frequently contribute to chronic renal failure and concomitant drug administration. The restoration of hormonal profiles after successful renal transplantation is still controversial. Immunosuppressive drugs may influence hormonal profiles. Our cross-sectional study of 37 male kidney transplant recipients investigated two groups according to their calcineurin inhibitor therapy, namely 21 cyclosporine versus 16 tacrolimus patients. The two groups were matched for age, graft function, mean duration of dialysis before transplantation, and duration of follow-up after transplantation. There was no statistical significant difference in baseline circulating levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TTE), and prolactin (PRL) between the two groups. We found that calcineurin inhibitors have favorable effects on sexual hormone levels of male renal transplant patients and that there is no difference in baseline hormone levels between cyclosporine- and tacrolimus-treated male patients. PMID:15013339

Kantarci, G; Sahin, S; Uras, A R; Ergin, H

82

Electrophysiological Assessment of the Autonomic Nervous System in Male Patients with Acromegaly  

Microsoft Academic Search

Background\\/Aims: We aimed to electrophysiologically evaluate the autonomic function in acromegalic patients using sympathetic skin response (SSR) as a reflection of the sympathetic sudomotor activity and RR interval variation (RRIV) as an indicator of the cardiovagal autonomic function. Methods: The study group consisted of 18 male acromegalics, and the control group was composed of 18 age- and sex-matched healthy subjects.

Mehmet Yücel; Hakan Akgün; Erol Bolu

2011-01-01

83

Hormone replacement therapy in morphine-induced hypogonadic male chronic pain patients  

PubMed Central

Background In male patients suffering from chronic pain, opioid administration induces severe hypogonadism, leading to impaired physical and psychological conditions such as fatigue, anaemia and depression. Hormone replacement therapy is rarely considered for these hypogonadic patients, notwithstanding the various pharmacological solutions available. Methods To treat hypogonadism and to evaluate the consequent endocrine, physical and psychological changes in male chronic pain patients treated with morphine (epidural route), we tested the administration of testosterone via a gel formulation for one year. Hormonal (total testosterone, estradiol, free testosterone, DHT, cortisol), pain (VAS and other pain questionnaires), andrological (Ageing Males' Symptoms Scale - AMS) and psychological (POMS, CES-D and SF-36) parameters were evaluated at baseline (T0) and after 3, 6 and 12 months (T3, T6, T12 respectively). Results The daily administration of testosterone increased total and free testosterone and DHT at T3, and the levels remained high until T12. Pain rating indexes (QUID) progressively improved from T3 to T12 while the other pain parameters (VAS, Area%) remained unchanged. The AMS sexual dimension and SF-36 Mental Index displayed a significant improvement over time. Conclusions In conclusion, our results suggest that a constant, long-term supply of testosterone can induce a general improvement of the male chronic pain patient's quality of life, an important clinical aspect of pain management.

2011-01-01

84

Prevalence of Priapism and Its Awareness amongst Male Homozygous Sickle Cell Patients in Lagos, Nigeria  

PubMed Central

Background. Priapism is a pathological condition of penile erection that persists beyond, or is unrelated to, sexual stimulation. Impotence and infertility are major problems in male sickle cell disease patients, and priapism has been implicated as a cause of impotence and infertility. The aim of this study is to determine priapism prevalence and assess the knowledge of male homozygous male patients about it in Lagos, Nigeria. Methods. A cross-sectional study was conducted amongst male homozygous sickle cell disease patients of Lagos State University Teaching Hospital. Pretested questionnaires were distributed to determine the prevalence and assess their knowledge on priapism. Data were analyzed using SPSS version 16.0. Results. A total of 114 consenting subjects filled the questionnaires, 85 of 114 (74.6%) had not heard about priapism before this study. A total of 77 of 114 (67.5%) did not know that they are at risk of priapism. Whilst 84 of 114 (73.7%) were not aware that priapism is a complication of SCD. The majority, 94 of 114 (82.5%), were not aware that priapism could cause impotence. Conclusion. There is a need to create more awareness about this complication amongst sickle cell disease patients in order to stem the incidence of impotence and infertility amongst them.

Adediran, Adewumi; Wright, Kikelomo; Akinbami, Akinsegun; Dosunmu, Adedoyin; Oshinaike, Olajumoke; Osikomaiya, Bodunrin; Ajibola, Sarah; Uche, Ebele; Ojelabi, Olaitan

2013-01-01

85

Prevalence of Priapism and Its Awareness amongst Male Homozygous Sickle Cell Patients in Lagos, Nigeria.  

PubMed

Background. Priapism is a pathological condition of penile erection that persists beyond, or is unrelated to, sexual stimulation. Impotence and infertility are major problems in male sickle cell disease patients, and priapism has been implicated as a cause of impotence and infertility. The aim of this study is to determine priapism prevalence and assess the knowledge of male homozygous male patients about it in Lagos, Nigeria. Methods. A cross-sectional study was conducted amongst male homozygous sickle cell disease patients of Lagos State University Teaching Hospital. Pretested questionnaires were distributed to determine the prevalence and assess their knowledge on priapism. Data were analyzed using SPSS version 16.0. Results. A total of 114 consenting subjects filled the questionnaires, 85 of 114 (74.6%) had not heard about priapism before this study. A total of 77 of 114 (67.5%) did not know that they are at risk of priapism. Whilst 84 of 114 (73.7%) were not aware that priapism is a complication of SCD. The majority, 94 of 114 (82.5%), were not aware that priapism could cause impotence. Conclusion. There is a need to create more awareness about this complication amongst sickle cell disease patients in order to stem the incidence of impotence and infertility amongst them. PMID:23956741

Adediran, Adewumi; Wright, Kikelomo; Akinbami, Akinsegun; Dosunmu, Adedoyin; Oshinaike, Olajumoke; Osikomaiya, Bodunrin; Ajibola, Sarah; Ismail, Kamal; Uche, Ebele; Ojelabi, Olaitan

2013-07-15

86

A Comparative Survey of Serum Androgenic Hormones Levels between Male Patients with Dermatophytosis and Normal Subjects  

Microsoft Academic Search

SUMMARY: Fungal growth can be influenced by human physiological mediators such as androgenic hormones. The aim of this study was to investigate a possible relationship between androgenic hormones and susceptibility to dermatophytosis. To this purpose we measured the levels of testosterone, androstendione, and dehydroepiandrosterone sulfate (DHEA-S) in 60 male patients with dermatophytosis due to Epidermophyton floccosum and Trichophyton rubrum by

Seyed Jamal Hashemi; Mohammad Reza Sarasgani; Kamiar Zomorodian

2004-01-01

87

Increased Expression of Visfatin in Monocytes and Macrophages in Male Acute Myocardial Infarction Patients  

PubMed Central

We demonstrated that visfatin expressed in monocytes and neutrophils and increased their reactivity in male acute ST-segment elevation myocardial infarction patients. Furthermore, visfatin was strongly appeared in lipid rich coronary rupture plaques and macrophages. These results suggest another explanation about leukocytes mediated visfatin that may play a pathogenesis role in coronary vulnerable plaques rupture.

Chiu, Cheng-An; Yu, Teng-Hung; Hung, Wei-Chin; Lu, Li-Fen; Chung, Fu-Mei; Tsai, I-Ting; Yang, Chih-Ying; Hsu, Chia-Chang; Lu, Yung-Chuan; Houng, Jer-Yiing; Lee, Yau-Jiunn; Wang, Chao-Ping

2012-01-01

88

Volumetric Evaluation of the Thalamus in Schizophrenic Male Patients Using Magnetic Resonance Imaging  

Microsoft Academic Search

Background: The thalamus, an important subcortical brain region connecting limbic and prefrontal cortices, has a significant role in sensory and cortical processing. Although inconsistently, previous studies have demonstrated neuroanatomical abnormalities in the thalamus of schizophrenic patients.Methods: This structural magnetic resonance imaging study, based on segmentation of contiguous coronal 1.5-mm images, compared thalamic brain volumes of 15 chronic, male schizophrenic patients

Chiara M. Portas; Jill M. Goldstein; Martha E. Shenton; Hiroto H. Hokama; Cynthia G. Wible; Iris Fischer; Ron Kikinis; Robert Donnino; Ferenc A. Jolesz; Robert W. McCarley

1998-01-01

89

Primary retroperitoneal mucinous cystadenocarcinoma in a male patient: a case report  

Microsoft Academic Search

In the literature, 51 cases of primary retroperitoneal mucinous cystadenocarcinoma have been published. We report the fourth case occurring in a male patient. The 42-year-old patient presented with multiple retroperitoneal cystic masses causing abdominal discomfort without alteration of the global clinical state. The masses were totally removed by a two-stage surgery. No other treatment has been introduced. After a follow-up

Abdelmalek Hrora; Sanae Reggoug; Houda Jallal; Farid Sabbah; Abdessalam Benamer; Mouna Alaoui; Mohamed Raiss; Mohamed Ahallat

2009-01-01

90

Iron accumulation in the liver of male patients with Wilson's disease  

Microsoft Academic Search

OBJECTIVES:There is accumulating evidence that ceruloplasmin, a copper protein with ferroxidase activity, plays an important role in iron metabolism. The genetic disorder, aceruloplasminemia, can lead to tissue storage of iron as in hemochromatosis. Because most patients with Wilson's disease, a genetic copper toxicosis, have hypoceruloplasminemia, some could be affected by iron overload.METHODS:Four male patients with Wilson's disease were enrolled in

Yuhta Shiono; Shinya Wakusawa; Hisao Hayashi; Toshikuni Takikawa; Motoyoshi Yano; Toshihide Okada; Hiroshi Mabuchi; Satoshi Kono; Hiroaki Miyajima

2001-01-01

91

Report of a male patient with brain metastases from breast cancer  

Microsoft Academic Search

As in female patients, the clinical course in male patients with breast cancer is determined mainly by tumor stage. The literature contains very limited data on either the occurrence or the treatment of CNS metastases.This paper presents the case report of a 69-year-old man with multiple brain metastases 7 years after a diagnosis of lymph-node positive breast cancer, which had

C Nieder; P. J Jost; A. L Grosu; C Peschel; M Molls

2003-01-01

92

A Study of the Bacterial Flora before and after Antiseptic Skin Preparation of the Perineum in Male Urology Patients  

Microsoft Academic Search

Objective: To establish the bacterial flora of the perineum before and after antiseptic preparation in male urology patients. Patients\\/Methods: Adult male patients undergoing cystoscopic procedures were studied. Three sets of swab specimens, labelled A, B and C, were taken from the perineum in the theatre. Specimen A was taken before cleaning and disinfection of the skin with Savlon® (Chlorhexidine- cetrimide

Elijah O. Kehinde; Yusuf Ali; Fathima Khodakhast; Wafaa Y. Jamal; Mohammed Seshah; Vincent O. Rotimi

2008-01-01

93

Cephalometric assessment of craniofacial morphology in Japanese male patients with obstructive sleep apnea-hypopnea syndrome.  

PubMed

CRANIOFACIAL MORPHOLOGICAL ANOMALIES CAN BE DIVIDED INTO TWO PRINCIPAL CATEGORIES: skeletal anomalies and soft tissue anomalies. This study examined the hypothesis that the assessment of indices representing both skeletal and soft tissue can be used to appropriately identify the risk factor of obstructive sleep apnea-hypopnea syndrome (OSAHS). 232 suspected OSAHS male patients were examined with polysomnography and divided into two groups (202 males with OSAHS and 30 male controls without OSAHS). Cephalometric analysis was performed on all patients to evaluate craniofacial morphological anomalies. The measurement sites were as follows: skeletal morphology; soft tissue morphology; mixed morphology including mandibular plane to hyoid bone (MP-H); and jaw soft tissue (JS) ratio; a novel ratio we defined, between the area of jaw and area of tongue with soft palate. JS ratio increased with AHI as well as MP-H. MP-H and JS ratio showed significant but weak correlation with apnea-hypopnea index. JS ratio was significantly associated with an increased risk for severe OSAHS, even after adjusting age and BMI, its odds ratio was the greatest among these variables. These results showed that mixed craniofacial, skeletal and soft tissue morphology are correlated with AHI, and JS ratio may be a useful parameters to explain the characteristics of OSAHS in male patients. PMID:23226092

Takai, Yujiro; Yamashiro, Yoshihiro; Satoh, Daisuke; Isobe, Kazutoshi; Sakamoto, Susumu; Homma, Sakae

2012-07-01

94

Cardiac Responses during Picture Viewing in Young Male Patients with Schizophrenia  

PubMed Central

Previous research investigating the emotion recognition ability in patients with schizophrenia has mainly focused on the recognition of facial expressions. To broaden our understanding of emotional processes in patients with schizophrenia, this study aimed to investigate whether these patients experience and process other emotionally evocative stimuli differently from healthy participants. To investigate this, we measured the cardiac and subjective responses of 33 male patients (9 with and 24 without antipsychotic medication) and 40 male control subjects to emotion-eliciting pictures. Cardiac responses were chosen as an outcome measure because previous research has indicated that these are linked with attentional and emotional processes and provide a more objective measure than self-report measures alone. The differences in cardiac responses between patients and controls were limited to medicated patients: only the medicated patients showed significantly decreased cardiac orienting responses compared with control subjects, regardless of picture contents. These results indicate that medicated patients directed less attention towards emotion-eliciting pictures than controls. Decreased attentional resources while processing emotional evocative stimuli could lead to incorrect appraisals of the environment and may have detrimental emotional and social consequences, contributing to chronic stress levels and an increased risk for cardiovascular disease.

Hempel, Roelie J.; Thayer, Julian F.; Roder, Christian H.; van Steenis, Hugo G.; van Beveren, Nico J. M.; Tulen, Joke H. M.

2012-01-01

95

Intentions of Women (18-25 Years Old) to Join the Military: Results of a National Survey.  

ERIC Educational Resources Information Center

In anticipation of the projected decline in the national population of young men and of expanding the role of women in the military, the Navy conducted a national telephone survey to gauge the interest of women and men in joining the military under present conditions and under three alternative options. The options related to expanding the role of…

Borack, Jules I.

96

Parental Influences on the Diets of 2-5-Year-Old Children: Systematic Review of Interventions  

ERIC Educational Resources Information Center

|During the early years, parents have a major influence on their children's diets, food choices and development of eating habits. However, research concerning the influence of parental feeding practices on young children's diets is limited. This paper presents a systematic review of intervention studies with parents of preschool children. The aim…

Peters, Jacqueline; Sinn, Natalie; Campbell, Karen; Lynch, John

2012-01-01

97

Parental influences on the diets of 2–5-year-old children: systematic review of interventions  

Microsoft Academic Search

During the early years, parents have a major influence on their children's diets, food choices and development of eating habits. However, research concerning the influence of parental feeding practices on young children's diets is limited. This paper presents a systematic review of intervention studies with parents of preschool children. The aim was to investigate the effectiveness of interventions that target

Jacqueline Peters; Natalie Sinn; Karen Campbell; John Lynch

2012-01-01

98

Parental influences on the diets of 2–5-year-old children: systematic review of interventions  

Microsoft Academic Search

During the early years, parents have a major influence on their children's diets, food choices and development of eating habits. However, research concerning the influence of parental feeding practices on young children's diets is limited. This paper presents a systematic review of intervention studies with parents of preschool children. The aim was to investigate the effectiveness of interventions that target

Jacqueline Peters; Natalie Sinn; Karen Campbell; John Lynch

2011-01-01

99

Clinical feminization and serum testosterone levels in male patients with chronic African endomyocardial fibrosis.  

PubMed

Thirteen out of 19 male patients aged sixteen years and above who had clinically diagnosed chronic African endomyocardial fibrosis (E.M.F.) had some clinical evidence of feminization. Serum was obtained from ten patients and assayed together with serum of ten age- and sex-matched normal controls for testosterone. The serum testosterone level in the 10 E.M.F. patients was uniformly below the lowest normal level, and the mean serum level for E.M.F. was significantly lower than the mean for the controls. Persistent and severe hepatic congestion in E.M.F. may lead to feminization long before cardiac cirrhosis occurs. PMID:7167998

Bolarin, D M; Andy, J J

1982-01-01

100

Circulating tumor cells count and characterization in a male breast cancer patient.  

PubMed

A 64-y-old man presented to Medical Oncology Department a metastatic invasive ductal breast carcinoma, positive for estrogen (ER) and progesterone receptors (PR) and Her2/neu negative. The patient was treated with different lines of therapy, with rapid radiological progression of disease. After four courses of a third-line chemotherapy, a radiological stable disease was maintained. The patient was followed by serial blood drawings for the characterization and count of circulating tumor cells (CTC). This is the first report concerning the predictive and prognostic value of CTC in a male breast cancer patient. PMID:21725206

Gazzaniga, Paola; Naso, Giuseppe; Raimondi, Cristina; Gradilone, Angela; Palazzo, Antonella; Gandini, Orietta; Petracca, Arianna; Nicolazzo, Chiara; Cortesi, Enrico; Frati, Luigi

2011-09-01

101

Semen alterations and flow-citometry evaluation in patients with male accessory gland infections.  

PubMed

Male accessory gland infections (MAGI) represent a major cause of male infertility mainly through the secretory dysfunction of the prostate, seminal vesicles, and epididymis. This study was undertaken to evaluate conventional and nonconventional sperm parameters in these patients, therefore 150 patients with MAGI were selected. Each of them underwent to two sperm analyses and evaluation of DNA fragmentation mitochondrial membrane potential (MMP), phosphatidylserine (PS) externalization, chromatin compactness, by flow cytometry. Results showed that patients with MAGI had a lower sperm progressive motility (11.4 ± 5.0 vs 34.0 ± 7.0%), and percentage of normal forms (9.0 ± 3.7 vs 33.0 ± 13.0%) compared to controls, instead, these patients showed higher number of seminal white blood cells (2.2 ± 1.0 vs 0.4 ± 0.6 106/ml). Patients with MAGI showed a higher number of spermatozoa with DNA fragmentation compared to controls (8.2 ± 3.0 vs 1.0 ± 1.0%). In addition, they have also a higher percentage of spermatozoa with low MMP (28.0 ± 4.0 vs 2.0 ± 2.0%). Patients with MAGI, showed a higher percentage of spermatozoa with PS externalization (8.0 ± 4.0 vs 3.0 ± 3.0%), an early sign of apoptosis, and lower percentage of viable spermatozoa (64.5 ± 12.0 vs 88.0 ± 10.0%). An increased percentage of spermatozoa with abnormal chromatin compactness (18.0 ± 4.0 vs 5.0 ± 3.0%) was found in patients with MAGI. In conclusion, patients with MAGI show alterations of conventional and biofunctional sperm parameters compared to controls. These results suggest to consider the flow cytometry evaluation among the diagnostic tools for male infertility. PMID:21946047

La Vignera, S; Condorelli, R; D'Agata, R; Vicari, E; Calogero, A E

2011-09-23

102

Male eating disorder patients with and without non-suicidal self-injury: a comparison of psychopathological and personality features.  

PubMed

In the present study, we investigated the prevalence and comorbidity of non-suicidal self-injury (NSSI) in male eating disorder (ED) patients. In total, 130 male ED patients completed a list of 10 impulse-control problems (including NSSI), the Eating Disorder Inventory-2, the Symptom Checklist-90-Revised and the Temperament and Character Inventory. Overall, 21% of the male ED patients (n?=?27) engaged in at least one type of NSSI, and we did not find significant differences between the ED subtypes. Self-injurious male ED patients showed significantly more severe ED symptoms and more affective, interpersonal and impulse-control problems than ED patients without NSSI. As previously described in female ED, our data confirm the affect regulation and impulse regulation functions of NSSI in male ED patients. PMID:21972149

Claes, Laurence; Jiménez-Murcia, Susana; Agüera, Zaida; Castro, Rita; Sánchez, Isabel; Menchón, Jose Manuel; Fernández-Aranda, Fernando

2011-10-04

103

Unirhinal olfactory identification deficits in young male patients with schizophrenia and related disorders: association with impaired memory function  

Microsoft Academic Search

We have observed discreet subgroups of male patients with psychotic disorders who have unirhinal olfactory identification deficits (microsmia). The purpose of this study was to examine the relationship between left or right nostril microsmia and performance on literalised neuropsychological tests sensitive to lesions in brain areas implicated in the pathogenesis of schizophrenia. Sixty-six male patients diagnosed with schizophrenia or related

Kimberley P Good; Jeffrey S Martzke; Heather I Milliken; William G Honer; Lili C Kopala

2002-01-01

104

A Group Psychotherapy Approach to the Treatment of Neurotic Symptoms in Male and Female Patients of Homosexual Preference  

Microsoft Academic Search

A group psychotherapy approach to the treatment of neurotic outpatients who show a homosexual preference in their sexual life is described. Male and female patients were treated in the same group. The characteristics of the patients, the differences between male and female members and some of the group dynamics, techniques and results obtained are presented.

L. Covi

1972-01-01

105

CHILDHOOD-ONSET ANOREXIA NERVOSA AND OBSESSIVE-COMPULSIVE DISORDER IN A MALE ADOLESCENT PATIENT: PROFILE OF NEUROCOGNITIVE FUNCTIONING  

Microsoft Academic Search

SUMMARY Background. Impairments of neurocognitive performance in female pa- tients with anorexia nervosa have been reported in many studies. To our know- ledge neuropsychological studies of male eating disorder patients remain rare. The goals of our study were to present the profile of neurocognitive functioning in a male adolescent anorexia nervosa patient and, given that the clinical manifestation of both

Anna Monika

106

Use of psychosocial support services among male Veterans Affairs colorectal cancer patients.  

PubMed

The authors describe use of psychosocial services within +/- 3 months of diagnosis among male colorectal cancer (CRC) patients treated within the Veterans Affairs (VA) health care system. Analysis included 1,199 patients with CRC treated at 27 VA medical centers primarily diagnosed between the periods 2005 to 2007. Of the patients, 78.6% received some form of psychosocial support, including 50.5% social work, 58.9% chaplain, 6.2% psychologist, 7.1% psychiatry, 3.5% mental health nurse, and 4.4% other. Logistic regression results indicate that rectal cancer patients were less likely to receive psychosocial services (odds ratio = .65, 95% confidence interval [0.43, 0.97]). The majority of patients in the VA receive some type of psychosocial service at the time of CRC diagnosis. PMID:21590571

Hamilton, Natia S; Jackson, George L; Abbott, David H; Zullig, Leah L; Provenzale, Dawn

2011-05-01

107

Corynebacterium seminalesp. nov., a New Species Associated with Genital Infections in Male Patients  

Microsoft Academic Search

significant quantities (10 4 to 10 5 CFU\\/ml) in semen specimens from infertile male patients with the diagnosis of prostatitis. These strains had characteristics of the genus Corynebacterium, such as 60 mol% G1 Ci n the DNA and corynemycolic acids,meso-diaminopimelic acid, arabinose, and galactose in the cell wall. Quantita- tive DNA-DNA hybridizations (S1 nuclease procedure) and phylogenies based on comparisons

P. RIEGEL; R. RUIMY; D. DEBRIEL; G. PREVOST; F. JEHL; F. BIMET; R. CHRISTEN

1995-01-01

108

Prevalence of HFE (hemochromatosis gene) mutations in unselected male patients with type 2 diabetes  

Microsoft Academic Search

To assess the prevalence of mutations in the HFE (hemochromatosis) gene in unselected male patients with type 2 diabetes, we examined 220 white men without known diabetes and 220 age-matched white men with type 2 diabetes for mutations in the HFE gene. Nucleotide 845 (C282Y) and 187(H63D) alleles were amplified by polymerase chain reaction (PCR) with lymphocyte DNA. The PCR

Michael J Sampson; Tracey Williams; Philip J Heyburn; Richard H Greenwood; Rosemary C Temple; Jennie Z Wimperis; Barbara A Jennings; Gavin A Willis

2000-01-01

109

Axillary Metastasis as the First Manifestation of Occult Breast Cancer in a Male Patient  

PubMed Central

Summary Background The aim of this study was to investigate the clinicopathologic features of male breast cancer. Case Report We present the clinicopathologic data of a 72-year-old male patient with occult breast cancer, who was diagnosed and underwent surgery in our hospital. The diagnosis was confirmed by histological examination, and the patient underwent modified radical mastectomy and axillary dissection. The histological examination showed no tumor foci in the resected breast tissue, but 2 of 15 dissected axillary lymph nodes were invaded by infiltrating ductal carcinoma. Immunohistochemistry staining was negative for both estrogen and progesterone receptors, but showed expression of p53 protein (+++), proliferating cell nuclear antigen (PCNA) (+++), Bcl-2 on-coprotein (+++), nm23 protein (++), multidrug resistance protein (MRP) (++), and human epidermal receptor (HER-2) oncoprotein (+++). 24 months after being diagnosed, the patient is alive without any residual or metastatic disease. Conclusions Breast cancer is very rare in men, and the occurrence of occult breast cancer is even less common. Axillary metastases can present as the first manifestation of breast cancer in a male.

Gu, Guo-Li; Wang, Shi-Lin; Wei, Xue-Ming; Ren, Li; Zou, Fu-Xian

2009-01-01

110

[Clinical results of infertility treatment to male patients with spinal cord injury].  

PubMed

It is difficult for male patients with spinal cord injury (SCI) to have children because of an ejaculation and dysfunction of spermatogenesis. However, owing to progress of assisted reproduction technology in recent years, it has become possible to have children even if the male has SCI, and the rate of success is improving gradually. During the 8 years from 1994 to 2002, infertility treatment was performed on 16 male patients with SCI consulting our hospital for acquistion of a child. We extracted their sperm by electroejaculation (EE) or testicular excision sperm extraction (TESE), and the sperm was artificially inseminated by the techniques such as artificial insemination with husband's semen (AIH), in vitro fertilization (IVF), and intracytoplasmic sperm injection (ICSI). Consequently, it was successful in 14 pregnancies on 10 couples, and resulted in 11 healthy live births on 7 couples. Four cases resulted in abortion. Two spouses are pregnant at present. There were no remarkable differences between the success group and the failure group in the quality of sperm such as concentration and motility. The mean age of the spouses who became pregnant was slightly lower than that of those who did not. Assisted reproduction techniques as EE and ICSI were useful techniques for patients with SCI wishing to have children. PMID:15032010

Komiya, Atsushi; Sato, Kazuhiko; Ishidoh, Tetsuo; Tanaka, Katsuyuki; Tomoda, Takeshi

2004-01-01

111

Fasting glucose level is associated with nocturnal hypoglycemia in elderly male patients with type 2 diabetes.  

PubMed

Abstract Background: Nocturnal hypoglycemia was a common and serious problem among patients with type 2 diabetes (T2DM), especially in the elderly. This study investigated whether fasting glucose was an indicator of nocturnal hypoglycemia in elderly male patients with T2DM. Methods: A total of 291 elderly male type 2 diabetic patients who received continuous glucose monitoring (CGM) between January 2007 and January 2011 were enrolled in the study. The association of fasting glucose and nocturnal hypoglycemia based on CGM data was analyzed, comparing with bedtime glucose. Results: Based on CGM data, patients with nocturnal hypoglycemia had significantly lower fasting glucose (5.88?±?1.29 versus 6.92?±?1.32?mmol/L) and bedtime glucose (7.33?±?1.70 versus 8.01?±?1.95?mmol/L) than patients without nocturnal hypoglycemia (both p?male patients with T2DM. Risk of nocturnal hypoglycemia significantly increased when fasting glucose was less than 6.1?mmol/L. PMID:23876123

Fang, Fusheng; Xiao, Haiying; Li, Chunlin; Tian, Hui; Li, Jian; Li, Zhibing; Cheng, Xiaoling

2013-07-22

112

Frequency of Fabry disease in male and female haemodialysis patients in Spain  

PubMed Central

Background Fabry disease (FD), an X-linked lysosomal storage disorder, is caused by a reduced activity of the lysosomal enzyme ?-galactosidase A. The disorder ultimately leads to organ damage (including renal failure) in males and females. However, heterozygous females usually present a milder phenotype with a later onset and a slower progression. Methods A combined enzymatic and genetic strategy was used, measuring the activity of ?-galactosidase A and genotyping the ?-galactosidase A gene (GLA) in dried blood samples (DBS) of 911 patients undergoing haemodialysis in centers across Spain. Results GLA alterations were found in seven unrelated patients (4 males and 3 females). Two novel mutations (p.Gly346AlafsX347 and p.Val199GlyfsX203) were identified as well as a previously described mutation, R118C. The R118C mutation was present in 60% of unrelated patients with GLA causal mutations. The D313Y alteration, considered by some authors as a pseudo-deficiency allele, was also found in two out of seven patients. Conclusions Excluding the controversial D313Y alteration, FD presents a frequency of one in 182 individuals (0.55%) within this population of males and females undergoing haemodialysis. Moreover, our findings suggest that a number of patients with unexplained and atypical symptoms of renal disease may have FD. Screening programmes for FD in populations of individuals presenting severe kidney dysfunction, cardiac alterations or cerebrovascular disease may lead to the diagnosis of FD in those patients, the study of their families and eventually the implementation of a specific therapy.

2010-01-01

113

Spontaneous Coronary Artery Dissection in a Male Patient with Takayasu's Arteritis and Antiphospholipid Antibody Syndrome  

PubMed Central

We present a case of a 34-year-old male who presented to the emergency ward with fever and abdominal pain. The diagnosis of Takayasu's arteritis and also antiphospholipid syndrome was made during an imaging workup of deep-vein thrombosis. A spontaneous coronary artery dissection was revealed in coronary CT angiography requested for chest pain and dyspnea. The patient was treated medically and discharged on close followup. The concurrence of spontaneous coronary artery dissection with antiphospholipid syndrome and Takayasu's arteritis has not been reported in the previous literature. The possibility of a spontaneous coronary artery dissection should be considered in patients presenting with both diseases.

Gerede, Demet Menekse; Yuksel, Bagdagul; Tutar, Eralp; Kucuksahin, Orhan; Uzun, Caglar; Atasoy, Kayhan Cetin; Duzgun, Nursen; Bengisun, Ugur

2013-01-01

114

Prevalence of Chlamydia trachomatis in urine of male patients with ankylosing spondylitis is not increased  

PubMed Central

OBJECTIVE—To compare the prevalence of Chlamydia trachomatis infections in ankylosing spondylitis (AS) patients with controls, using DNA amplification assays in urine specimens.?METHODS—The prevalence of C trachomatis infections was assessed in 32 male AS patients and 120 age and sex matched controls. Urine specimens were tested by ligase chain reaction and polymerase chain reaction. In addition, blood samples of AS patients were tested on serum antibodies to C trachomatis (IgA and IgG) by a specific peptide based solid phase enzyme immunoassay. A questionnaire was used to assess the differences in sexual behaviour and ethnic origin between the two groups. AS patients were also asked about disease characteristics.?RESULTS—No significant differences were found between cases and controls in the prevalence of C trachomatis infections. No associations were found between C trachomatis antibodies and disease characteristics, except for acute anterior uveitis (AAU). Four of eight (50%) AS men positive for IgG had a history of AAU in comparison with three of 24 (12.5%) IgG negative men (OR = 7.0; 95% confidence intervals: 1.1, 44.1).?CONCLUSION—The prevalence of Chlamydia trachomatis infections, as detected by commercially available DNA amplification assays in urine specimens, in AS patients is not higher compared with male controls of the same age. However, there seems to be an association between specific antibodies to C trachomatis and AAU.??

van der Paardt, M; van Denderen, J C; van den Brule, A J C; Morre, S; van der Horst-Bru..., I E; Bezemer, P; Dijkmans, B

2000-01-01

115

Lobular Breast Cancer in a Male Patient with a Previous History of Irradiation Due to Hodgkin's Disease  

PubMed Central

Background Male breast cancer is rare and represents less than 1% of all breast cancers. Considering the fact that the male breast most often does not consist of lobules and acini, lobular carcinoma of the male breast is exceptionally rare. Case Report In this paper we present a unique case of alveolar variant of lobular male breast cancer in a 56-year-old patient. Conclusion According to our knowledge this is the first presentation of an alveolar variant of lobular male breast cancer that appeared 14 years after chemo- and radiotherapy for the treatment of Hodgkin's disease.

Ninkovic, Srdjan; Azanjac, Goran; Knezevic, Milan; Radovanovic, Dragce; Canovic, Dragan; Nedovic, Jasmina; Mitrovic, Slobodanka

2012-01-01

116

Estimation the Frequency of Human Immunodeficiency Virus among Male and Female Patients, Iran  

PubMed Central

Objective: A reduction in new human immunodeficiency virus(HIV) cases is one of the ten areas prioritized by the United Nations Program on HIV. However, recent official reports confirm the HIV rate is increasing and predicted a huge incidence in the near future in Iran, despite the preventative program by Iran's Health Ministry. In this descriptive study, we evaluate the frequency of HIV positive cases among referral patients to a private clinic laboratory for its diagnosis in addition to specimens from other laboratories. An epidemiological analysis is also performed. Materials and Methods: In this descriptive study, the total number of patients was 138 cases that referred for the diagnosis of HIV to the private Laboratory. Of these, 93 males (67.4%) and 45 females (32.6%) voluntarily requested to be examined for specific increases in specific antibody titer, western blot assays and RNA quantitation polymerase chain reaction. We collected two separate tubes of whole blood, one for reverse transcriptasepolymerase chain reaction analysis and the second one for the remaining two tests. Those patients who were antibody positive by western blot and/or reverse transcriptase-polymerase chain reaction(RT-PCR) analyses were considered as HIV positive cases. Results: There were 18.84% confirmed HIVcases (17.39% males; 1.45% females). Analysis of the results confirmed that the ratio of male to female patients in the infected group was not comparable to those in the suspect group. The majority of HIV positive cases were either infected by their partner via sexual intercourse (84.61%) or needle sticks (11.53%) among the drug addicted group. The infection routes of the remainder were unknown. Conclusion: Analysis of the data revealed a higher frequency of HIVin males than females among the tested group. There was a shift in to unsafe sexual intercourse as seen in the present study. The higher rate of infected male patients shows a shift in transmission route to unsafe intercourse. Therefore, it is necessary to design new supportive programs by actively identifying and contacting at-risk groups, particularly infected females who are uninterested in being and monitored.

Hajia, Masoud; Amirzargar, Ali; Ghoreishi, Mehdi; Sam, Sohrab

2012-01-01

117

Molecular cytogenetic analysis of a ring-Y infertile male patient.  

PubMed

In the present study, we report on the case of a 43-year-old male patient seeking for fertility assistance, who showed a seminal analysis and testicular biopsy of complete azoospermia. Peripheral blood culture for chromosome studies revealed a karyotype of 46 chromosomes with a ring-Y-chromosome that lost the long arm heterochromatin. Molecular analysis of genomic DNA from the patient detected the presence of the sex-determining region of the Y-chromosome (SRY) but the complete absence of regions involved in spermatogenesis (AZFa, AZFb, AZFc). Several molecular markers distributed along the Y-chromosome were tested through PCR amplification, and a breakpoint was established close to the centromere, predicting the deletion of the growth control region, in agreement with the short stature observed in this patient. All results obtained through molecular cytogenetic characterization are in accordance with the clinical features observed in this patient. PMID:17469055

Carvalho, F M; Wolfgramm, E V; Degasperi, I; Verbeno, B M; Vianna, B A; Chagas, F F; Perroni, A M S; Paula, F; Louro, I D

2007-03-09

118

Cardiovascular disease and metabolic risk factors in male patients with schizophrenia, schizoaffective disorder, and bipolar disorder.  

PubMed

The authors determined whether diagnoses of cardiovascular disease (CVD) and CVD-related conditions differed by psychiatric diagnosis among male Veterans Administration patients from the mid-Atlantic region. Among 7,529 patients (mean age: 54.5 years), the prevalence of diagnoses ranged from 3.6% (stroke) to 35.4% (hypertension). Compared with schizophrenia patients, those with bipolar disorder were 19% more likely to have diabetes, 44% more likely to have coronary artery disease, and 18% more likely to have dyslipidemia, after adjustment. Clinical suspicion for CVD-related conditions, as well as risk-modification strategies, in patients with serious mental illness should incorporate differences in prevalence across specific psychiatric diagnoses. PMID:17878500

Kilbourne, Amy M; Brar, Jaspreet S; Drayer, Rebecca A; Xu, Xiangyan; Post, Edward P

119

Analysis of FMR-1 locus in a mentally retarded male patient: Mosaicism or duplication?  

SciTech Connect

Analysis of the CGG repeat region in the FMR-1 allele(s) in a mentally retarded male patient showed two discrete and different sized bands in the premutation range. Southern analysis with EcoRI and EagI revealed bands estimated to represent 54 and 139 repeats of the trinucleotide CGG. Neither band was methylated. No normal sized band was detected. The size of the 54 CGG repeat was confirmed by polyacrylamide gel electrophoresis of the PCR product spanning the CGG repeat region; the 139 repeat was too large for this analysis. Two discrete bands, an unexpected result in a male patient, could represent somatic mosaicism of a single allele. However, in other patients, mosaicism results in a smeared band representing a range of fragment sizes rather than 2 discrete bands. Alternatively, two such bands could indicate that our patient has 2 copies on the FMR-1 allele. A cytogenetic analysis was performed to investigate fragile sites or a duplication. No fragile site was observed in 100 unbanded metaphases examined, ruling out the presence of fragile X in greater than 3% of cells with 0.95 confidence. No evidence of rearrangement of the X chromosome was seen in 50 cells examined, ruling out 6% or greater mosaicism at 0.95 confidence level. A duplication of the FMR-1 allele that is below the resolution of these techniques cannot be ruled out. Physical exam of this patient showed characteristic facies of fragile X syndrome and macroorchidism. The patient had an uncle with mental retardation and similar features and a brother with mental retardation. Clinical symptoms of fragile X are not expected in a patient with an unmethylated FMR-1 allele and an expansion in the premutation range. It is unclear whether the features consistent with fragile X syndrome in this patient are related to the observed molecular occurrences at the FMR-1 allele.

Moore, D.K.; Evans, J.P.; Levy-Lahad, E. [Univ. of Washington, Seattle, WA (United States)] [and others

1994-09-01

120

A case report of a male patient with Hb Hammersmith [?42(CD1)Phe?Ser, TTT>TCT].  

PubMed

All Hb Hammersmith [?42(CD1)Phe?Ser, TTT>TCT] patients reported so far have been female, suggesting that this condition may occur as a negative, fatal intrauterine selection against males. In this case report, we describe a male case of Hb Hammersmith. A 6-month-old male patient, born from ovum donation, presented with hemolytic anemia and cyanosis. Hemoglobin (Hb) electrophoresis revealed decreased Hb A (54.0%) and Hb A(2) (0.3%) and markedly increased Hb F (45.7%) levels. Direct sequencing revealed a missense mutation in the HBB gene, c.128T>C (p.Phe42Ser), which is known as Hb Hammersmith. This mutation was not identified in any of this patient's family members. This is the first case of Hb Hammersmith in a male patient, and this study demonstrates that Hb Hammersmith is likely a non fatal condition for males during the intrauterine period. PMID:22217314

Park, Seungman; Kang, Hyoung Jin; Cho, Sung Im; Kim, So Yeon; Seong, Moon-Woo; Park, Sung Sup

2012-01-04

121

Influence of erectile dysfunction on health related quality of life of male kidney transplant patients.  

PubMed

The objective of the present study was to investigate if a psychological adaptation capacity exists in kidney transplant bearers, even with ageing, in relation to erectile dysfunction (ED). We studied ED using IIEF-5 and health-related quality of life (HRQoL) using the SF-36 Health Survey, in a large sample of male renal transplant patients (n=242), searching for the influence of ED on HRQoL. Patients included 199 patients (82%); the median age was 52 y (43-62); 106 patients (54.9%) presented ED. These patients were divided into four groups according to median age. SF-36 scores were worse for ED vs non-ED patients in the first three age groups, but not in age group 4. SF-36 Mental Component Summary was similar for patients with ED and without ED in all age groups. We confirm the hypothesis that a psychological adaptation occurs in renal transplant patients in all age groups, when suffering ED. PMID:14961058

Rebollo, P; Ortega, F; Valdés, C; Fernández-Vega, F; Ortega, T; García-Mendoza, M; Gómez, E

2004-06-01

122

Quality of Life Assessment in Male Patients with Androgenetic Alopecia: Result of a Prospective, Multicenter Study  

PubMed Central

Background Androgenetic alopecia (AGA) is a common hair loss disease with genetic predisposition among men and women, and it may commence at any age after puberty. It may significantly affect a variety of psychological and social aspects of one's life and the individual's overall quality of life (QoL). Objective This study aimed to investigate the QoL of AGA patients and discover the factors that can influence the QoL of AGA patients, including previous experience in non-medical hair care, reasons for hospital visits, age, duration, and the severity of AGA. Methods A total of 998 male patients with AGA were interviewed, using the Hair Specific Skindex-29 to evaluate the QoL of AGA patients. Results The results of the Hair Specific Skindex-29 on patients with AGA were as follows: symptom scale: 26.3±19.5, function scale: 24.0±20.1, emotion scale: 32.1±21.8, and global score: 27.3±19.1. According to this assessment, QoL was more damaged if the patient had severe alopecia, a longer duration of AGA, younger age, had received previous non-medical hair care, and visited the hospital for AGA treatment. Conclusion This study showed that AGA could harmfully affect the patients' QoL. These findings indicate that dermatologists should address these QoL issues when treating patients with alopecia.

Han, Sung-Hyub; Byun, Ji-Won; Lee, Won-Soo; Kang, Hoon; Kye, Yong-Chul; Kim, Ki-Ho; Kim, Do-Won; Kim, Moon-Bum; Kim, Seong-Jin; Kim, Hyung-Ok; Sim, Woo-Young; Yoon, Tae-Young; Huh, Chang-Hun; Hwang, Seung-Sik; Ro, Byung-In

2012-01-01

123

Simultaneous double coronary thrombosis in a 47-year-old male patient with acute myocardial infarction  

PubMed Central

Patient: Male, 47 Final Diagnosis: Acute myocardial infarction Symptoms: Chest pain Medication: — Clinical Procedure: — Specialty: Cardiology Objective: Unusual clinical course Background: Double myocardial infarction involving two culprit major vessels is a rarely reported presentation with high incidence of mortality. Case Report: In this study, we report 47-year-old male patient who had an attack of chest pain associated with ST-segment elevation in the antero-lateral leads. Pharmaco-invasive reperfusion approach was adopted with full dose tissue plasminogen activator, followed by transferring the patient to a specialized heart center for Percutaneous Coronary Intervention (PCI). Coronary angiography showed a fresh thrombus totally occluding Left Anterior Descending (LAD) and another thrombus causing distal total occlusion of a dominant Right Coronary Artery (RCA). Two Bare metal stents were placed in both lesions with Thrombolysis in Myocardial Infarction (TIMI) 3 flow post dilatation, but the patient, unfortunately, went into Ventricular Fibrillation (VF) followed by asystole and died 35 minutes later. Conclusions: Acute double vessel coronary artery thrombosis is a serious event that requires prompt diagnosis and management to prevent its complications.

Ahmed, Mahmoud; Abdul, Arabi

2013-01-01

124

Decreased serum chemerin levels in male Japanese patients with type 2 diabetes: sex dimorphism.  

PubMed

Chemerin, a recently discovered adipocytokine plays an important role in obesity and obesity-associated metabolic complications. However, the role of chemerin in the pathogenesis of type 2 diabetes mellitus (T2DM) has not fully been elucidated. We compared the serum chemerin levels and metabolic parameters between 88 control subjects, 86 patients with metabolic syndrome (MS), and 147 patients with T2DM in a Japanese population and further analyzed their correlation. Enzyme-linked immunosorbent assay was used to measure the serum chemerin levels. The chemerin levels were significantly higher in male than in female control subjects (p < 0.005), with significant decreases in patients with T2DM compared with those with MS and control subjects (164.9 ± 6.3 ng/mL vs. 209.8 ± 7.7 and 218.7 ± 7.3 ng/mL; p < 0.0001 vs. p < 0.0001, respectively) but no significant differences in female subjects. The multiple regression analysis revealed that the chemerin levels negatively correlated with the fasting glucose and HbA1c levels in total and male subjects. In the patients with T2DM, the chemerin levels negatively correlated with fasting glucose and high-density lipoprotein cholesterol but positively correlated with body mass index (BMI), and total cholesterol and triglyceride levels. The negative correlation between the chemerin and fasting glucose levels remained significant after adjustment for age, sex, and BMI in the total and male subjects and those with T2DM. These results suggest the role of chemerin in sex dimorphism and a potential link between chemerin levels and T2DM pathogenesis in a Japanese population. PMID:22986456

Takahashi, Michiko; Inomata, Sumie; Okimura, Yasuhiko; Iguchi, Genzo; Fukuoka, Hidenori; Miyake, Kazuaki; Koga, Daisuke; Akamatsu, Suguru; Kasuga, Masato; Takahashi, Yutaka

2012-10-13

125

[Development of ulcerative colitis in a male patient during exacerbation of Reiter's syndrome symptoms].  

PubMed

Three years observation of a male patient was presented, who manifested Reiter's syndrome with two relapses of the disease, associated with the typical triad of symptoms (acute arthritis, conjunctivitis, urethritis). Both relapses were accompanied by diarrhoea. In course the first relapse skin lesions were observed on both shanks, diagnosed as erythema nodosum. Complex studies on diarrhoea, performed during the first relapse, failed to doxycyclin and diclofenac. During the second relapse of Reiter's syndrome the diarrhoea was diagnosed to result from co-existing colitis ulcerosa. Serum titers of Chlamydia trachomatis antibodies were low during relapse, increased during patient's recovery and persisted at the high during asymptomatic period. High titers of such antibodies were noted also in the serum of the patient's wife in whom neither anamnesis nor physical examination could demonstrate any pathology. PMID:9296898

Kara?, Z; Zaba, R; Zabel, J; Jazienicki, B; Witoszy?ski, S

1997-01-01

126

Matched-pair analysis of patients with female and male breast cancer: a comparative analysis  

PubMed Central

Background Male breast cancer (MBC) is a rare disease accounting for approximately 1% of all breast carcinomas. Presently treatment recommendations are derived from the standards for female breast cancer. However, those approaches might be inadequate because of distinct gender specific differences in tumor biology of breast cancer. This study was planned in order to contrast potential differences between female and male breast cancer in both tumor biological behavior and clinical management. Methods MBC diagnosed between 1995-2007 (region Chemnitz/Zwickau, Saxony, Germany) was retrospectively analyzed. Tumor characteristics, treatment and follow-up of the patients were documented. In order to highlight potential differences each MBC was matched with a female counterpart (FBC) that showed accordance in at least eight tumor characteristics (year of diagnosis, age, tumor stage, nodal status, grade, estrogen- and progesterone receptors, HER2 status). Results 108 male/female matched-pairs were available for survival analyses. In our study men and women with breast cancer had similar disease-free (DFS) and overall (OS) survival. The 5-years DFS was 53.4% (95% CI, range 54.1-66.3) in men respectively 62.6% (95% CI, 63.5-75.3) in women (p > 0.05). The 5-years OS was 71.4% (95% CI, 62.1-72.7%) and 70.3% (95% CI, 32.6-49.6) in women (p > 0.05). In males DFS analyses revealed progesterone receptor expression as the only prognostic relevant factor (p = 0.006). In multivariate analyses for OS both advanced tumor size (p = 0.01) and a lack of progesterone receptor expression were correlated (p = 0.01) with poor patients outcome in MBC. Conclusion Our comparative study revealed no survival differences between male and female breast cancer patients and gives evidence that gender is no predictor for survival in breast cancer. This was shown despite of significant gender specific differences in terms of frequency and intensity of systemic therapy in favor to female breast cancer.

2011-01-01

127

The evaluation of sexual dysfunction in male patients with migraine and tension type headache  

PubMed Central

Background Erectile dysfunction (ED), defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance, is a common condition. The psychological, hormonal, neurogenic and arterial pathologies, medications, chronic diseases have been reported in the etiology of the ED. This paper aims to study sexual dysfunction in the male patients with migraine and Tension type headache (TTH). Methods 30 migraine cases (Group M), 31 TTH cases (Group T) and 30 control cases (Group C) were included in the study. Patients were evaluated with medical history, physical examination, body mass index (BMI), Beck Depression Inventory, biochemical analysis and hormone profiles. ED was evaluated via International Index of Erectile Function Scale (IIEF). In statistical analysis, variant analysis, post-hoc tukey test, Pearson correlation test, t-test, and fisher's exact chi-square test were used. Results The patients' mean age was 34.96+/?1.30, 35.54+/?1.52 and 32.26+/?1.38 for group M,T and C, respectively. There was no significant difference between the groups in terms of testosterone levels. Mean IIEF scores was 19.83+/?2.2, 20.39+/?1.35 and 27.83+/?0.34 in groups M,T,C. When M and T groups were compared with group C, there were significant differences, and there was no statistical difference when T and M groups were compared to each other. Beck Depression Scores were not significantly different in groups M, T and C. Conclusion In this study, it was shown that, migraine and TTH affects the sexual functions negatively in male patients. Chronic diseases may cause sexual disorders in patients because of despair, guilt, and fear of death or pain. Our results suggest that, along with the effect of chronic disease and pain, there must be other complicated factors exist causing the development of SD in patients with migraine and TTH.

2013-01-01

128

The relationship between bisphosphonate use and demographic characteristics of male osteoporosis patients  

PubMed Central

INTRODUCT?ON: This study aimed to investigate a number of demographic characteristics in males with osteoporosis (OP) treated with bisphosphonate and determine whether any of these measures could act as an effective indicator of medication persistence and compliance. MATERIAL AND METHOD: Among the patients with OP who applied to our clinic and were prescribed weekly oral bisphosphonate treatment, 89 patients over 50 years of age were included in this study. The demographic characteristics of these patients were evaluated. The number of medications used by the patients over the past 1 and 3 years were counted, and the persistence and compliance with bisphosphonate treatment was estimated. The patients were divided into two groups: fully compliant and noncompliant subjects. The two groups of patients were compared separately for 1 and 3 years while considering their demographic characteristics. RESULTS: The mean age of the 89 patients included in the study was 62.43±9.41 years. Comparisons among the studied demographic characteristics during the 1-year period of medication use indicated that the educational status of the fully compliant patients was higher. During the 3-year period of medication use, educational status was the only demographic characteristic that was determined to be significantly lower in the noncompliant patients than in the fully compliant group. CONCLUSION: Although deficiencies in medication persistence and compliance during osteoporosis treatment can lead to serious health and social problems in both genders, the causes of these deficiencies have not been thoroughly clarified. We suggest that the educational status of the patient may contribute to these deficiencies.

Cevikoi, Alev; Umay, Ebru; Polat, Sevgi; Ecerkale, Oznur; Cakci, Aytul

2011-01-01

129

Risk of Hypogonadism From Scatter Radiation During Pelvic Radiation in Male Patients With Rectal Cancer  

SciTech Connect

Purpose: Recent studies have reported fluctuations in sex hormones during pelvic irradiation. The objective of this study was to observe the effects of radiation on hormonal profiles for two treatment modalities: conventional external beam radiotherapy (EBRT) and high-dose-rate brachytherapy (HDRBT) given neoadjuvantly for patients with rectal cancer. Methods and Materials: Routine serum follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels were collected from 119 consecutive male patients receiving either EBRT, using 45.0-50.4 Gy in 25-28 fractions with concurrent 5-fluorouracil chemotherapy or HDRBT using 26 Gy in 4 fractions. Results: Thirty patients with initially abnormal profiles were excluded. Profiles included in this study were collected from 51 patients treated with EBRT and 38 patients treated with HDRBT, all of whom had normal hormonal profiles before treatment. Mean follow-up times were 17 months for the entire patient cohort-14 and 20 months, respectively-for the EBRT and HDRBT arms. Dosimetry results revealed a mean cumulative testicular dose of 1.24 Gy received in EBRT patients compared with 0.27 Gy in the HDRBT group. After treatment, FSH and LH were elevated in all patients but were more pronounced in the EBRT group. The testosterone-to-LH ratio was significantly lower (p = 0.0036) in EBRT patients for tumors in the lower third of the rectum. The 2-year hypogonadism rate observed was 2.6% for HDRBT compared with 17.6% for EBRT (p = 0.09) for tumors in the lower two thirds of the rectum. Conclusion: HDRBT allows better hormonal sparing than EBRT during neoadjuvant treatment of patients with rectal cancer.

Yau, Ivan [Department of Physiology, McGill University, Montreal (Canada); Vuong, Te [Department of Radiation Oncology, McGill University, Montreal (Canada)], E-mail: te.vuong@muhc.mcgill.ca; Garant, Aurelie [Faculty of Medicine, Laval University, Quebec (Canada); Ducruet, Thierry [Department of Statistics, McGill University, Montreal (Canada); Doran, Patrick [Department of Endocrinology, McGill University, Montreal (Canada); Faria, Sergio [Department of Radiation Oncology, McGill University, Montreal (Canada); Liberman, Sender [Department of Colorectal Surgery, McGill University, Montreal (Canada); Richard, Carole [Department of Colorectal Surgery, University of Montreal, Montreal (Canada); Letellier, Francois [Pierre Boucher Hospital, Department of Surgery, Longueil (Canada); Charlebois, Patrick [Department of Colorectal Surgery, McGill University, Montreal (Canada); Loungnarath, Rasmy [Department of Colorectal Surgery, University of Montreal, Montreal (Canada); Stein, Barry [Department of Colorectal Surgery, McGill University, Montreal (Canada); Devic, Slobodan [Department of Medical Physics, McGill University, Montreal (Canada)

2009-08-01

130

Fragile X Premutation Carriers: Characteristic MR Imaging Findings of Adult Male Patients with Progressive Cerebellar and Cognitive Dysfunction  

Microsoft Academic Search

BACKGROUND AND PURPOSE: Our purpose was to characterize the findings of MR imaging of the brain of adult male fragile X premutation carriers with a recently identified disorder characterized by ataxia, tremor, rigidity, and cognitive dysfunction. METHODS: MR imaging studies of the brain of 17 male patients were characterized for signal intensity and for size of ventricles, cerebral and cerebellar

James A. Brunberg; Sebastien Jacquemont; Randi J. Hagerman; Elizabeth M. Berry-Kravis; Jim Grigsby; Maureen A. Leehey; Flora Tassone; W. Ted Brown; Claudia M. Greco; Paul J. Hagerman

131

Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: A potential link between epigenetics and schizophrenia  

Microsoft Academic Search

Genetic and epigenetic factors can potentially alter susceptibility to psychiatric disorders such as schizophrenia. In order to explore the effect of epigenetics on the pathogenesis of schizophrenia, we examined the global methylation level of leukocyte DNA from 210 patients with schizophrenia (124 males and 86 females) and 237 healthy subjects (108 males and 129 females). Methylated deoxycytidine (mC) content in

Morihiro Shimabukuro; Tsukasa Sasaki; Akira Imamura; Takahiro Tsujita; Chiaki Fuke; Tadashi Umekage; Mamoru Tochigi; Kennichi Hiramatsu; Tetsuji Miyazaki; Takaya Oda; Jun Sugimoto; Yoshihiro Jinno; Yuji Okazaki

2007-01-01

132

Social desirability response set and systematic distortion in the self-report of adult male gender patients  

Microsoft Academic Search

This study showed that the “socially desirable” presentation for a heterosexual male gender dysphoric is one that emphasizes traits and behaviors characteristic of “classic” transsexualism. Fifty-one homosexual and 64 heterosexual adult male gender patients were administered the Crowne-Marlowe (1964) Social Desirability Scale as well as eight questionnaire measures that tapped various features of the clinical history commonly given great weight

Ray Blanchard; Leonard H. Clemmensen; Betty W. Steiner

1985-01-01

133

Seminal leukocyte concentration and related specific reactive oxygen species production in patients with male accessory gland infections  

Microsoft Academic Search

The aim of this study was to determine whether differences occur in seminal concentrations of white blood corpuscles (sWBC) and whether WBC production of reactive oxygen species (ROS) is related to the infiltration of one or more male sexual glands. We studied 70 infertile patients affected by bacterial male accessory gland infections (MAGI) who were divided clinically and, by ultrasound

E. Vicari

1999-01-01

134

Male patients with congestive heart failure and their conception of the life situation.  

PubMed

Patients with congestive heart failure (CHF) are an extensive group in Sweden both with regard to prevalence and number of medical care events. As the age of the population and survival after myocardial infarction are increasing, the incidence of CHF is also on the rise. The aim of this study is to describe, from a nurse's perspective, how male patients with CHF conceive their life situation. Interview questions were designed with a focus on five dimensions: the biophysical, the sociocultural, the emotional, the intellectual, and the spiritual-existential. A qualitative method was used with a phenomenographic approach as it examines aspects of the surroundings as conceived. In the results, six categories emerged: feeling a belief in the future, gaining awareness, feeling support from the environment, feeling limitation, feeling a lack of energy and feeling resignation. The mental and physical lack of energy which patients feel easily leads to limited working capacity and social activities. This limitation may cause patients with CHF to believe that neither they nor their environment can influence their life situation and there is a risk that these patients become resigned. In order to help them get out of this vicious circle of limitation and resignation, it is important that the nurse teaches them self-care and shows them the possibilities that exist in everyday life. With increased awareness of their life situation, patients may adapt to their CHF and see that it is possible to improve their future themselves. PMID:9080286

Mårtensson, J; Karlsson, J E; Fridlund, B

1997-03-01

135

Prevalence of hypersexual behavior in Parkinson's disease patients: Not restricted to males and dopamine agonist use  

PubMed Central

This study investigates the prevalence and demographic characteristics of hypersexuality in Parkinson’s disease (PD). Impulse control disorders in PD patients have been associated with dopamine agonist therapy. Moreover, hypersexuality and pathological gambling have been associated with males, while females may be inherently thought to be more likely to participate in compulsive shopping and binge-eating behaviors. In this study, a screening mail-in survey was sent to all PD patients at a single Movement Disorders Center. One hundred forty one of 400 (35.3%) research packets were returned completed. Fifteen of 141 patients met initial screening criteria for hypersexual behavior. After detailed interview, only 6/141 (4.3%) of PD patients met criteria for pathologic hypersexual behavior. These behaviors included: compulsive masturbation, prostitution, and paraphilias. Patients with a younger age of PD onset were more likely to exhibit hypersexual behavior. Unlike previous report, no significant association was found between hypersexuality and gender or dopamine agonist use. Rather, this study suggests that physicians should be vigilant for hypersexual behavior in all PD patients, regardless of gender and PD medication regimen. Ultimately, given the innate sensitivity of the topic and survey limitations, it is very likely that hypersexual behavior in our cohort, as it is in the general PD population, has been under-reported.

Cooper, Christine A; Jadidian, Armon; Paggi, Michelle; Romrell, Janet; Okun, Michael S; Rodriguez, Ramon L; Fernandez, Hubert H

2009-01-01

136

FDG PET\\/CT Demonstrates Malignant Fibrous Histiocytoma in a Patient with Nasopharyngeal Carcinoma after Radiation Therapy  

Microsoft Academic Search

A 25-year-old young male is a victim of undifferentiated nasopharyngeal carcinoma (NPC) s\\/p an 8,200 cGy external radiation therapy about 5 years ago, who was referred to our positron emission tomography (PET) center for evaluating a protruding mass in his nasal cavity. 18 F-fluorodeoxyglucose positron emission tomog- raphy\\/computed tomography (FDG PET\\/CT) imaging incidentally demonstrated a hypermetabolic lesion in the right

Chih-Yung Chang; Shiou-Chi Cherng; Yi-Jen Peng; Daniel H. Y. Shen; Wen-Sheng Huang; Cheng-Yi Cheng

137

Risk of Intimate Partner Violence among Young Adult Males with Childhood ADHD  

PubMed Central

Objective Research has clearly documented the social dysfunction of youth with attention-deficit hyperactivity disorder (ADHD). However, little is known about the interpersonal relationships of adults diagnosed with ADHD in childhood, including rates of intimate partner violence (IPV). Method Using data from the Pittsburgh ADHD Longitudinal Study, analyses compared the level of IPV (verbal aggression, violence) reported by young adult (18-25 year-old) males with childhood ADHD (n=125) to reports by demographically-similar males without ADHD histories (n=88). Results Males with childhood ADHD, especially those with conduct problems persisting from childhood, were more likely to be verbally aggressive and violent with romantic partners than males without histories of ADHD or conduct problems. Conclusion Research is needed to replicate these findings, to explore potential mechanisms, and to develop effective interventions for romantic relationship discord among young adults with ADHD histories, especially those with persistent conduct problems.

Wymbs, Brian T.; Molina, Brooke S. G.; Pelham, William E.; Cheong, JeeWon; Gnagy, Elizabeth M.; Belendiuk, Katherine A.; Walther, Christine A. P.; Babinski, Dara E.; Waschbusch, Daniel A.

2010-01-01

138

Detection of Human Herpesviruses (HHVs) in Semen of Human Male Infertile Patients.  

PubMed

Recently we demonstrated an ectopic expression of the human herpesvirus 1 thymidine kinase (HHV1-TK) gene by functioning of an intrinsic endogenous promoter in the transgenic rat (TG-rat), suggesting that HHV1 infection in humans induces expression of the TK gene with the ectopic promoter in the testis and results in accumulation of HHV1-TK protein, triggering male infertility similar to that in the TG-rat. Hence, in this study, we started to investigate a relationship between infection of herpesvirus and human male infertility. Semen was donated by Chinese male infertile patients (153 men, aged 21-49 years) with informed consent, followed by DNA preparation and analysis by PCR and DNA sequencing. Semen volume, sperm number and density, and sperm mortality were examined. DNAs of HHV1, HHV3, HHV5 and HHV6 were confirmed by PCR, electrophoresis and DNA sequencing. Finally, virus DNA was identified in 59 patients (39%). The number of carriers was 39 (25%) for HHV1, 6 (4%) for HHV4, 33 (22%) for HHV5 and 3 (2%) for HHV6, respectively. Moreover, double-infection was found in 22 out of 59 specimens (37%), most of which were double-infection of HHV1 and HHV5 (15 out of 22 carriers). Though slight severity was present in some of the carriers, the relationship between virus infection and sperm impairment was not conclusive. Accordingly, it is essential to examine whether the viral HHV1-TK gene is expressed in the testis of the infertile human HHV carrier. PMID:23748714

Chen, Mo; Cai, Li-Yi; Kanno, Naoko; Kato, Takako; Lu, Jinxing; Jin, Fan; Wang, Honghua; Sekita, Masayo; Higuchi, Masashi; Yoshida, Saishu; Yako, Hideji; Ueharu, Hiroki; Izumi, Shun-Ichiro; Kato, Yukio

2013-06-10

139

A case of PDH-E1? mosaicism in a male patient with severe metabolic lactic acidosis  

Microsoft Academic Search

We have characterized a novel mutation in a male patient that affects the coding sequence of PDH-E1a gene and changes arginine-141 to a leucine. This nucleotide substitution was found in about 75% of the studied DNA (fibroblasts, liver and muscle), a scenario that would indicate a case of E1a mosaicism in a male patient. When the mutant E1a protein was

A. Seyda; K. Chun; S. Packman; B. H. Robinson

2001-01-01

140

Discriminant function analysis of factors related to myocardial infarction in male patients on antihypertensive therapy.  

PubMed Central

Records of 367 male patients who began attending the Dunedin Hospital Hypertension Clinic between 1959 and 1969 were coded up to the end of 1972. Of these patients, 60 had their first myocardial infarction, or sudden cardiac death without previous evidence of myocardial infarction, while they were attending the clinic. This infarct group was compared with a control group of 120 which was chosen from the remaining patients so that the two groups would be comparable with regard to their age and year of first attendance. A stepwise discriminant function analysis showed that the basal systolic and diastolic pressures measured when patients started attending the clinic were the variables with the most significant difference. Further analysis showed that inclusion of the average casual standing systolic pressure when patients were receiving antihypertensive therapy improved the discrimination between the groups. The average casual standing diastolic pressure during antihypertensive therapy also improved the discrimination, but, curiously enough, with a negative sign in the discriminant function. Quetelet's index of obesity similarly improved the discrimination, obese subjects having less risk of infarction or sudden death. Serum cholesterol, however, was not related to prognosis.

Smith, A H; Simpson, F O

1976-01-01

141

'A father is being beaten': constructions in the analysis of some male patients.  

PubMed

I will suggest that the phantasy of 'a father is being beaten' and its transformations emerges for certain male patients as a result of the work of analysis and becomes a potential appropriation of the (symbolic) father. The symbolic beating of the father takes place at the threshold between an anal-sadistic organization and the oedipal situation. The phantasy of the 'father being beaten' does not necessarily mean that it is the father who is explicitly being beaten. It is a construction derived from the free associations and dreams, in the analytic encounter, reached through the work of interpretation. Detailed material of sessions of the five times a week analysis of one of my patients will be presented. This will be contrasted with material from four other analyses of male patients where the 'father being beaten' phantasy was not achieved. The common feature in all these other configurations is a foreclosure in the relationship to the father and a lack of an internalization of the paternal function as a symbolic capacity. It is my suggestion that this absence of the father in its symbolic function is then sexualized in a fusion between life and death drives. A final contrasting example is derived from Karl Abraham's classic paper detailing the analysis of a patient where one can interpret a dream as expressing 'a father is being beaten' phantasy; however the dream's repetitive nature and its links with a current dream in the analysis points out to a lack of differentiation between the sexes and an anal-sadistic organization. PMID:21323880

Perelberg, Rosine Jozef

2011-02-01

142

'Speedy action over goal orientation': cognitive impulsivity in male forensic patients with dyslexia.  

PubMed

Previous neuropsychiatric studies suggest a relationship between reading disability and cognitive impulsivity. This relationship is not entirely explained by the high comorbidity between reading disability and attention deficit hyperactivity disorder (ADHD), as children with a co-occurrence of these disorders tend to be more impulsive than those with ADHD only. Other research has demonstrated that poor verbal skill (irrespective of the presence of dyslexia) deficits in executive functions and impulsivity are important risk factors for criminal behaviour. The present study bridges these two research traditions by examining whether patients undergoing forensic psychiatric investigation who also have dyslexia, have a cognitive style characterized by impulsivity. Male forensic patients (mean age 27?years, range 16-35) with (n?=?9) and without (n?=?13) dyslexia were evaluated on the computerized EuroCog test battery. The findings suggest that patients with dyslexia tend to use a cognitive impulsive style and suggest a more direct link between dyslexia and cognitive impulsivity that is not mediated by the presence of ADHD. In order to identify treatment needs and tailor treatment accordingly, forensic patients should be assessed with respect to poor verbal skill, dyslexia and impulsivity. PMID:23059751

Dåderman, Anna M; Meurling, Ann Wirsén; Levander, Sten

2012-11-01

143

Determinants of Osteopenia in Male Renal-Stone-Disease Patients with Idiopathic Hypercalciuria  

PubMed Central

Summary Background and objectives Bone demineralization is frequent in renal-stone formers with hypercalciuria. Although this pathologic link has been recognized for decades, the underlying mechanisms and risk factors associated with osteopenia/osteoporosis in this population remain partially understood. Design, setting, participants, & measurements This study retrospectively analyzed determinants of low bone mineral density (BMD) in 65 idiopathic hypercalciuric male renal-stone formers. Clinical and biologic evaluation included BMD measurement, bone-remodeling markers, analysis of calcium metabolism with oral calcium load test, and dietary inquiry. Results Patients with osteopenia (n = 23, 35% of the population) presented significantly higher fasting calciuria as compared with normal bone density patients (n = 42) (calcium/creatinine ratio was 0.32 versus 0.24 mmol/mmol; P = 0.006). Analysis of the whole population revealed a negative association between fasting hypercalciuria and BMD (P = 0.003), independent of confounding variables including body-mass index and tobacco consumption. The fasting calcium/creatinine ratio above 0.25 mmol/mmol was associated with a 3.8-fold increase in the risk of low BMD. Conclusion In our study, fasting hypercalciuria after a 2-day calcium-restricted diet appears as the only biologic factor associated with low BMD, suggesting a bone-calcium efflux. Our results support the view of a parathyroid-independent pathologic process that remains to be identified. Hypercalciuric patients with low BMD do not excrete more calcium in 24-hour urine samples than patients without low BMD.

Traxer, Olivier; Daudon, Michel; Tligui, Mohammed; Hubert-Brierre, Jerome; Guerrot, Dominique; Sebag, Aline; Baud, Laurent; Haymann, Jean-Philippe

2011-01-01

144

Patient-specific FDG dosimetry for adult males, adult females, and very low birth weight infants  

NASA Astrophysics Data System (ADS)

Fluorodeoxyglucose is the most commonly used radiopharmaceutical in Positron Emission Tomography, with applications in neurology, cardiology, and oncology. Despite its routine use worldwide, the radiation absorbed dose estimates from FDG have been based primarily on data obtained from two dogs studied in 1977 and 11 adults (most likely males) studied in 1982. In addition, the dose estimates calculated for FDG have been centered on the adult male, with little or no mention of variations in the dose estimates due to sex, age, height, weight, nationality, diet, or pathological condition. Through an extensive investigation into the Medical Internal Radiation Dose schema for calculating absorbed doses, I have developed a simple patient-specific equation; this equation incorporates the parameters necessary for alterations to the mathematical values of the human model to produce an estimate more representative of the individual under consideration. I have used this method to determine the range of absorbed doses to FDG from the collection of a large quantity of biological data obtained in adult males, adult females, and very low birth weight infants. Therefore, a more accurate quantification of the dose to humans from FDG has been completed. My results show that per unit administered activity, the absorbed dose from FDG is higher for infants compared to adults, and the dose for adult women is higher than for adult men. Given an injected activity of approximately 3.7 MBq kg-1, the doses for adult men, adult women, and full-term newborns would be on the order of 5.5, 7.1, and 2.8 mSv, respectively. These absorbed doses are comparable to the doses received from other nuclear medicine procedures.

Niven, Erin

145

Increased nocturnal melatonin secretion in male patients with hypogonadotropic hypogonadism and delayed puberty.  

PubMed

Hypogonadotropic hypogonadism (IGD) and constitutional delayed puberty (DP) share a common pathophysiologic process, i.e. GnRH deficiency. Both conditions are heterogenous and exhibit different grades of GnRH deficiency. To discern whether these disorders of GnRH deficiency are associated with altered melatonin secretion profiles, we compared untreated young males IGD (n = 7) and DP (n = 7) to normal pubertal male controls (n = 6). Serum samples for melatonin, LH, and prolactin concentrations were obtained every 15 min from 1900 h to 0700 h in a controlled light-dark environment with simultaneous sleep recordings. Mean (+/- SD) darktime nocturnal melatonin levels were significantly higher in IGD (259 +/- 73 pmol/L) and DP (217 +/- 29 pmol/L) compared with 182 +/- 69 pmol/L in controls (P < 0.02). So were the mean (+/- SD) peak melatonin levels (410 +/- 117, 327 +/- 97 and 298 +/- 95 pmol/L in IGD, DP, and controls, respectively (P < 0.05). Integrated nocturnal melatonin secretion values (AUC) were also higher in IGD and DP (168 +/- 45 and 134 +/- 28) compared with 119 +/- 45 pmol/min.1 x 10(3) in controls (P < 0.02). The time of melatonin peak and the time of onset of the nocturnal melatonin rise were observed earlier in IGD and DP. Light-time mean (+/- SD) serum melatonin levels were similar in all three groups. No correlations were found between melatonin and LH levels, nor between melatonin and prolactin levels. These data indicate that melatonin secretion is increased in male patients with GnRH deficiency. The lack of correlations between melatonin and LH suggest that circulating sex steroids, rather than LH, modulate melatonin secretion in a reverse fashion. PMID:7608268

Luboshitzky, R; Lavi, S; Thuma, I; Lavie, P

1995-07-01

146

The effect of yoga therapy on selected psychological variables among male patients with insomnia.  

PubMed

Background: An estimated 30-50% of the general population is affected by insomnia and 10% have chronic insomnia. Yoga therapy is beneficial in such disorders and it has fewer side effects.Aim: The aim of this study was to find out the effect of yoga therapy on selected psychological variables among men with insomnia.Methods: Forty males with insomnia were divided randomly into 2 groups (the experimental and the control groups). The experimental group received eight weeks of yoga therapy, while the control group did not receive any therapy. The pre and post treatment stress and the self confidence scores were taken.Results: There was a significant improvement in the stress scores and the self confidence scores in the experimental group. There were neither any side effects nor any drop outs.Conclusion: We conclude that yoga is an effective treatment option for the patients with insomnia. There are no major side effects. PMID:23450219

Sobana, R; Parthasarathy, S; Duraisamy; Jaiganesh, K; Vadivel, S

2013-01-01

147

The Effect of Yoga Therapy on Selected Psychological Variables Among Male Patients with Insomnia  

PubMed Central

Background: An estimated 30-50% of the general population is affected by insomnia and 10% have chronic insomnia. Yoga therapy is beneficial in such disorders and it has fewer side effects. Aim: The aim of this study was to find out the effect of yoga therapy on selected psychological variables among men with insomnia. Methods: Forty males with insomnia were divided randomly into 2 groups (the experimental and the control groups). The experimental group received eight weeks of yoga therapy, while the control group did not receive any therapy. The pre and post treatment stress and the self confidence scores were taken. Results: There was a significant improvement in the stress scores and the self confidence scores in the experimental group. There were neither any side effects nor any drop outs. Conclusion: We conclude that yoga is an effective treatment option for the patients with insomnia. There are no major side effects.

Sobana, R.; Parthasarathy, S.; Duraisamy; Jaiganesh, K.; Vadivel, S.

2013-01-01

148

Ciprofloxacin Resistance in Enterococcus faecalis Strains Isolated From Male Patients With Complicated Urinary Tract Infection  

PubMed Central

Purpose Urinary tract infection (UTI) is one of the most prevalent bacterial infections, and fluoroquinolone therapy is a well-known standard regimen for UTI. The prevalence and risk factor analysis of fluoroquinolone resistance in enterococcal UTIs are not well documented. The aim of this study was to evaluate the antimicrobial susceptibility and risk factors for ciprofloxacin resistance in Enterococcus faecalis strains isolated from patients with complicated UTI. Materials and Methods We evaluated 81 E. faecalis strains isolated from 81 male patients at a single teaching hospital over 3 years. The Vitek 2 automatic system was used for antimicrobial susceptibility analysis. Results Antimicrobial resistance rates were rare for ampicillin/sulbactam, imipenem, and vancomycin in E. faecalis. Forty-six percent of the E. faecalis strains were resistant to levofloxacin, 47% were resistant to ciprofloxacin, and 58% were resistant to norfloxacin. E. faecalis strains were highly resistant to erythromycin (92%) and ftetracycline (96%). The risk factor analysis revealed that age intervals, the underlying diseases, catheterization, and the number of admissions did not increase the risk of ciprofloxacin resistance, whereas patients with hospital-acquired infection (odds ratio [OR], 18.15; 95% confidence interval [CI], 3.46 to 95.13; p=0.001), patients who were treated in a urological department (OR, 6.15; 95% CI, 1.5 to 25.41; p=0.012), and patients who were transferred from health care centers (OR, 7.393; 95% CI, 1.32 to 41.22; p=0.023) had an increased risk of ciprofloxacin resistance compared with the matched controls. Conclusions Ciprofloxacin is no longer a recommended therapy for E. faecalis from complicated UTI in men with risk factors. We suggest that ampicillin/sulbactam can be recommended as alternatives for treating ciprofloxacin-resistant E. faecalis strains associated with UTI in Korea.

2013-01-01

149

Molecular, biochemical, and phenotypic analysis of a hemizygous male with a severe atypical phenotype for X-linked dominant Conradi-Hunermann-Happle syndrome and a mutation in EBP.  

PubMed

X-linked dominant Conradi-Hunermann-Happle syndrome (CDPX2; MIM 302960) is a rare chondrodysplasia punctata primarily affecting females. CDPX2 is presumed lethal in males, although a few affected males have been reported. CDPX2 is a cholesterol biosynthetic disorder due to 3-beta-hydroxysteroid-delta8,delta7-isomerase deficiency caused by mutations in the emopamil binding protein (EBP) gene. A 2.5-year-old Caucasian male was followed from the age of 6 weeks and noted to have significant developmental delay, hypotonia, seizures, and patchy hypopigmentation. Multiple congenital anomalies included a unilateral cataract, esotropia, crossed renal ectopia, stenotic ear canals, and failure to thrive, requiring G-tube placement. Multiple minor anomalies and ptosis were noted. No skeletal asymmetry or chondrodysplasia punctata were noted on skeletal survey at 6 weeks and 13 months. An extensive genetic work-up including cholesterol (126-176 mg/dl) and 7-dehydrocholesterol was unrevealing. However, the levels of 8(9)-cholestenol and 8-dehydrocholesterol were mildly increased in plasma, which was confirmed in cultured fibroblasts. This prompted molecular analysis of the EBP gene, which revealed a novel hemizygous (nonmosaic) mutation in exon 2 (L18P). Two restriction digests were developed that confirmed this mutation in skin fibroblasts, blood, and buccal cells (all nonmosaic). We determined that the patient's mother (adopted) also has the L18P mutation enabling prenatal diagnosis of a normal male fetus. She has normal stature, no asymmetry, no cataracts at this time, and has a patch of hyperpigmentation on her chest best visualized on Woods lamp examination, characteristic of CDPX2. The mild maternal phenotype has been described previously. However, this nonmosaic missense mutation has resulted in a severe phenotype in her surviving son. PMID:12503101

Milunsky, Jeff M; Maher, Thomas A; Metzenberg, Aida B

2003-01-30

150

Aesthetic restoration of Poland's syndrome in a male patient using free anterolateral thigh perforator flap as autologous filler.  

PubMed

We report a case of a male patient with Poland's anomaly who was reconstructed with a free anterolateral thigh perforator flap. The flap was used successfully as an autologous filler to recreate the anterior axillary line and correct the chest contour deformity. The use of the free anterolateral thigh perforator flap is an excellent choice as an autologous filler to correct mild and moderate deformity in male Poland's syndrome, carrying low morbidity and leaving both minimal scarring and functional sequelae. PMID:19296523

Gravvanis, Andreas; Lo, Steven; Shirley, Rebecca

2009-01-01

151

Transcatheter Closure of Secundum Atrial Septal Defect in Patients Over 60 Years Old  

PubMed Central

Background and Objectives Atrial septal defect (ASD) is the one of most common congenital heart diseases detected in adults. Along with remarkable development of device technology, the first treatment strategy of secundum ASD has been transcatheter closure in feasible cases. However, there are only a few publications regarding the results of transcatheter closure of ASD in elderly patients, especially those over 60 years of age. We report our results of transcatheter closure of ASD in patients over 60 years old. Subjects and Methods Between May 2006 and December 2011, 31 patients over 60 years old (25 female and 6 male; mean 66.7±5.25 years old, range 61-78 years old) were referred to our center. Results A total of 23 patients underwent therapeutic catheterization to close secundum ASD, and the closure was successful in 22 patients (95.7%). All patients who underwent the procedure survived except for one patient who expired because of left ventricular dysfunction. A small residual shunt was observed in two (9%) of 21 patients before discharge but disappeared at follow-up. All patients eventually had complete closure. There were five patients who had coronary problems. One patient underwent percutaneous coronary intervention using a stent at the same time as transcatheter closure of ASD. Atrial arrhythmias were detected in 6 of 23 patients (26.1%) before the procedure. One patient was successfully treated by radiofrequency ablation before the procedure. No patients displayed new onset arrhythmia during the follow-up period. Follow-up echocardiographic evaluation showed a significantly improved right ventricular geometry. Conclusion We conclude that transcatheter closure of ASD is a safe and an effective treatment method for patients over 60 years old if the procedure is performed under a thorough evaluation of comorbidities and risk factors.

Woo, Saet Byul; Kim, Seong-Ho; Kim, Soo-Jin; Lee, Sang-Yun; Baek, Jae-Sook; Shim, Woo-Sup

2013-01-01

152

Human papillomavirus infection in urine samples from male renal transplant patients.  

PubMed

Renal allograft recipients have a well-documented increased incidence of human papillomavirus (HPV)-related malignancies and preventive strategies should be specifically implemented. While in females the use of the Papanicolau test and HPV detection assay are used currently as a screening test for cervical cancer, no diagnostic procedures have been implemented to monitor HPV infection in males. The aim of this study was to test for HPV infection and to determine the spectrum of viral genotypes in urine samples of men with renal transplants. The study included 88 patients who underwent kidney transplantation between 1999 and 2005. HPV sequences were detected by nested PCR, using the broad-spectrum consensus-primer pairs MY09/MY11 and the new MGP system, and characterized by nucleotide sequence analysis. Overall, 43 (48.9%) samples were found positive for HPV sequences and the most common genotypes were HPV 16 (53.5%) and HPV 54 (9.3%) followed by HPV 6, 53, 56, 58, 66, 11, 12, 20, 45, 62, and 71, in descending order of prevalence. The majority of HPV 16 isolates were classified as European and only one as African-1 variant on the basis of nucleotide signature present within the MGP L1 region. The high prevalence of HPV 16 among renal allograft recipients suggests that an HPV-16-based preventive or therapeutic vaccine may be effective for prevention or treatment of HPV-related neoplasia in this group of immune compromised patients. PMID:20513081

Tornesello, Maria Lina; Loquercio, Giovanna; Tagliamonte, Maria; Rossano, Fabio; Buonaguro, Luigi; Buonaguro, Franco Maria

2010-07-01

153

What are the antioxidant status predictors' factors among male chronic obstructive pulmonary disease (COPD) patients?  

PubMed

Imbalance between antioxidant and oxidative stress is a major risk factor for pathogenesis of some chronic diseases such as chronic obstructive pulmonary disease (COPD). This study aimed to determine antioxidant and oxidative stress status, and also theirs association with respiratory function of male COPD patients to find the antioxidant predictors' factors. A total of 149 subjects were involved in a cross-sectional study. The study was conducted at two medical centers in Kuala Lumpur, Malaysia. Results of the study showed that plasma vitamin C was low in most of the subjects (86.6%). Total antioxidant capacity was the lowest in COPD stage IV compare to other stages (p < 0.05). Level of plasma vitamin A (p= 0.012) and vitamin C (p= 0.007) were low in malnourished subjects. The predictors for total antioxidant capacity were forced vital capacity (FVC) % predicted and intake of ?-carotene (R2= 0.104, p= 0.002). Number of cigarette (pack/ year) and smoking index (number/ year) were not associated with total antioxidant capacity of this COPD population. Plasma oxidative stress as assessed plasma lipid peroxidation (LPO) was only positively correlated with plasma glutathione (p= 0.002). It might be a need to evaluate antioxidant status especially in older COPD patients to treat antioxidant deficiency which is leading to prevent COPD progression. PMID:23283038

Pirabbasi, Elham; Najafiyan, Mahin; Cheraghi, Maria; Shahar, Suzana; Abdul Manaf, Zahara; Rajab, Norfadilah; Abdul Manap, Roslina

2012-11-04

154

Domestic violence among male and female patients seeking emergency medical services.  

PubMed

Gender differences among a cohort of injured patients seeking emergency medical services were examined with respect to their experiences as perpetrators and/or victims of domestic violence. Contextual issues, including violence initiation, emotional and behavioral responses to partner-initiated violence, and injury frequency and severity were analyzed. Women reported male partner-initiated violence more frequently than men reported female partner-initiated violence. Behavioral responses to partner initiated violence varied. Women were more likely to report using force back and to involve law enforcement. Women were more likely to be injured in a domestic assault over their lifetime, within the last year, and at the time of recruitment. Comparison of injury severity revealed that women reported higher rates of injuries than men in all possible severity categories. Women also reported experiencing more fear than men during partner-initiated violence, as well as being subjected to larger numbers of dominating and controlling behaviors, and greater intimidation secondary to their partner's size. Understanding contextual differences in partner violence for women and men has significant implications for policy development, identification, treatment, and referral of patients identified as living in violent relationships. PMID:16075666

Phelan, Mary Beth; Hamberger, L Kevin; Guse, Clare E; Edwards, Shauna; Walczak, Suzanne; Zosel, Amy

2005-04-01

155

Investigation of Helicobacter pylori in bronchoscopic lung specimens of young male patients with bronchiectasis but without gastrointestinal symptoms.  

PubMed

Anti-Helicobacter pylori IgG serum levels were measured in 31 young male bronchiectasis patients without gastrointestinal symptoms, and 56 healthy males. The possible presence of H. pylori was also investigated by rapid urease tests, culture and histopathological examination of protected catheter brush and biopsy specimens from the bronchiectatic site. No serological, microbiological or histological evidence of H. pylori infection was found in the bronchiectasis patient group. H. pylori did not appear to be an agent of infection or chronic colonisation in bronchiectasis, and may not have a significant role in the progression of this disease. PMID:15008949

Ilvan, A; Ozturkeri, H; Capraz, F; Cermik, H; Kunter, E

2004-03-01

156

Clinical considerations in the chiropractic management of the patient with Marfan syndrome  

Microsoft Academic Search

Objective: To describe the chiropractic management of a patient with whiplash-associated disorder and a covert, concomitant dissecting aneurysm of the thoracic aorta caused by Marfan syndrome or a related variant. Clinical Features: A 25-year-old man was referred by his family physician for chiropractic assessment and treatment of neck injuries received in a motor vehicle accident. After history, physical examination, and

Jeffrey R. Tuling; Edward T. Crowther; Phyllis McCord

2000-01-01

157

[Testicular germ cell tumor arising in the male with a chromosomal abnormality of 45,X/46,X,del(Y)].  

PubMed

A 25-year-old-man came to our outpatient clinic complaining of swelling of the left scrotal contents. He had a past history of 3 surgeries for hypospadia. His left testis was stony hard and testicular tumor was suspected. High orchiectomy was performed under general anesthesia. The pathological diagnosis was mixed type testicular germ cell tumor. Chromosomal analysis revealed a karyotype of 45,X/46,X,del(Y). Most of the long arm of the Y chromosome was missing. Prophylactic chemotherapy was performed. Treatment options for genetically high risk patients of testicular malignancies were discussed. PMID:22343745

Tomomasa, Hiroshi; Iiyama, Tetsuro; Okada, Hiroshi

2012-01-01

158

MECP2 mutation in male patients with non-specific X-linked mental retardation  

Microsoft Academic Search

In contrast to the preponderance of affected males in families with X-linked mental retardation, Rett syndrome (RTT) is a neurological disorder occurring almost exclusively in females. The near complete absence of affected males in RTT families has been explained by the lethal effect of an X-linked gene mutation in hemizygous affected males. We report here on a novel mutation (A140V)

Alfredo Orrico; Ching-Wan Lam; Lucia Galli; Maria Teresa Dotti; Giuseppe Hayek; Sui-Fan Tong; Priscilla M. K. Poon; Michele Zappella; Antonio Federico; Vincenzo Sorrentino

2000-01-01

159

Gender differences in living conditions found among male and female schizophrenic patients on a follow-up study.  

PubMed

In four provinces of Canada schizophrenic patients who had received psychiatric treatment not less than 18 months and not more than 10 years earlier, were interviewed. Findings suggest that the female schizophrenic patient, having a later age of onset than the male patient, and being more likely to form a stable spousal union, appears to enjoy a protected status which confers with the benefits of higher income levels, better housing and lessened likelihood of being placed in residential care. A further demonstration of the advantaged circumstances of the female patients may well be their superior showing on functional outcome indicators, where they out-performed males on all indices except physical activity at significant levels of differentiation. PMID:4044155

Wattie, B J; Kedward, H B

1985-01-01

160

Comparison of urine, first and second endourethral swabs for PCR based detection of genital Chlamydia trachomatis infection in male patients  

Microsoft Academic Search

Objectives: To compare endourethral swabs and urine as diagnostic specimens for the detection of genital Chlamydia trachomatis infection using the polymerase chain reaction (PCR), in male patients attending a genitourinary clinic and to assess whether the first endourethral swab used solely for diagnosing gonococcal infection could be used for C trachomatis detection as well.Methods: Two endourethral swabs were taken from

H Sugunendran; H D L Birley; H Mallinson; M Abbott; C Y W Tong

2001-01-01

161

Autonomic neuropathy, QT interval lengthening, and unexpected deaths in male diabetic patients  

Microsoft Academic Search

Summary  QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomic neuropathy group than the normal group.

D. J. Ewing; O. Boland; J. M. M. Neilson; C. G. Cho; B. F. Clarke

1991-01-01

162

Correlation between testosterone, gonadotropins and prolactin and severity of negative symptoms in male patients with chronic schizophrenia  

Microsoft Academic Search

The aim of this study was to evaluate the relationship between plasma levels of testosterone, FSH, LH and prolactin and the severity of negative symptoms in patients with chronic schizophrenia. Fifty-four male inpatients with chronic schizophrenia participated in this cross-sectional study. Twenty-five age-matched men without a history of psychiatric disorders or endocrine illnesses were used as controls. All patients were

Shahin Akhondzadeh; Farzin Rezaei; Bagher Larijani; Ali-Akbar Nejatisafa; Ladan Kashani; Seyed Hesameddin Abbasi

2006-01-01

163

In young post-myocardial infarction male patients elevated plasminogen activator inhibitor-1 correlates with insulin resistance and endothelial dysfunction.  

PubMed

Classical and nonclassical risk factors contribute to the development of myocardial infarction (MI) in young patients. The aim of the present study was to find out whether insulin resistance and impaired fibrinolysis, with increased plasminogen activator inhibitor (PAI-1), are present in young male post-MI patients, and their relation to additional markers of cardiovascular risk such as endothelial dysfunction (ED) and intima-media thickness (IMT). Forty-one male patients (on average 44 years old) in the stable phase after MI were recruited, with 25 healthy males who did not differ from patients regarding age as controls. Body mass index (BMI) and waist-to-hip ratio were measured and insulin resistance was calculated. Several coagulation/fibrinolytic parameters and inflammation markers were measured. ED was estimated by ultrasound measurement of the flow-mediated dilatation (FMD) of the brachial artery, and IMT was measured on the common carotid artery. BMI was increased in post-MI patients in comparison with healthy controls. Compared with the control group, in post-MI patients PAI-1 antigen (13.8 ± 10.6 vs 9.1 ± 7.6 ng/ml, P = 0.042), PAI-1 activity (14.8 ± 10.8 vs 9.0 ± 8.0 IU/ml, P = 0.015), and fibrinogen were significantly elevated. In patients increased PAI-1, antigen and activity were both significantly positively related to insulin resistance. We found an important negative relation between PAI-1 antigen and FMD (r = -0.32, P = 0.04) and between PAI-1 activity and FMD (r = -0.39, P = 0.01). Our results suggest that PAI-1 can be a link between obesity, insulin resistance, and MI in young patients. It is thus concluded that impaired fibrinolysis with increased PAI-1 may be an important nonclassical risk factor for MI, particularly in young males with increased BMI and insulin resistance. PMID:23001714

Eržen, Barbara; Šabovi?, Mišo

2012-09-22

164

Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction  

Microsoft Academic Search

Korean ginseng and mountain ginseng (Panax ginseng CA Meyer) are important traditional herbal plants whose ginsenosides are generally accepted as serving to improve sexual functions, such as penile erection. We investigated the effects of tissue-cultured mountain ginseng extract (TMGE) on male patients with erectile dysfunction (ED). A double-blind, placebo-controlled study was conducted with 143 patients experiencing ED. Over the course

Tae-Hwan Kim; Seung Hyun Jeon; Eun-Joo Hahn; Kee-Yoeup Paek; Jong Kwan Park; Nae Young Youn; Hyung-Lae Lee

2009-01-01

165

Long-term, Multicenter Study of the Safety and Efficacy of Topical Alprostadil Cream in Male Patients with Erectile Dysfunction  

Microsoft Academic Search

Introduction. Alprostadil is approved for treatment of male erectile dysfunction (ED) by injection or urethral insertion. Topical delivery of alprostadil offers an improved alternative. Aim. To evaluate the long-term safety and efficacy of topical alprostadil cream. Methods. This was a multicenter, open-label, long-term study in 1,161 patients (998 double-blind rollover; 163 naïve) with ED. For the first 4 weeks, patients

Michael Rooney; William Pfister; Mary Mahoney; Melissa Nelson; James Yeager; Christopher Steidle

2009-01-01

166

Nephropathy in males and females with Fabry disease: cross-sectional description of patients before treatment with enzyme replacement therapy  

Microsoft Academic Search

Background. Fabry disease, an X-linked genetic disorder with deficient ?-galactosidase A activity, is characterized by kidney disease and kidney failure. The spectrum of kidney disease has not been well defined, especially in female patients. Methods. We did a cross-sectional retrospective analysis of natural history of glomerular filtration rate (estimated— eGFR), albuminuria and proteinuria in 1262 adult patients (585 males, 677

Alberto Ortiz; P. Oliveira; S teven Waldek; David G. Warnock; Bruno Cianciaruso; Christoph Wanner

167

Body images of patients with anorexia nervosa, bulimia nervosa and female control subjects: A comparison with male ideals of female attractiveness  

Microsoft Academic Search

Body images of female patients with anorexia nervosa and bulimia nervosa were assessed against females without eating disorders and compared with male ideals of female attractiveness. A computer program was applied to examine body images of 62 patients with anorexia nervosa, 45 patients with bulimia nervosa, and 40 female and 39 male control subjects. Body size overestimation was most distinct

Dieter Benninghoven; Lena Raykowski; Svenja Solzbacher; Sebastian Kunzendorf; Günter Jantschek

2007-01-01

168

Evaluation of cadmium and zinc in biological samples of tobacco and alcohol user male mouth cancer patients.  

PubMed

There is compelling evidence in support of positive associations between zinc (Zn) deficiency and high accumulation of cadmium (Cd) in biological samples of different cancerous patients. The incidence of mouth cancer has been increased among people who possess habit of drinking alcohol, tobacco smoking and chewing with gradients in Pakistan. In the present study, Cd and Zn contents of blood and scalp hair samples of 92 male mouth cancer patients and 78 referents of same age group (range 35-65 years), socio-economic status, localities and dietary habits. Among referent male subjects, 56 consumed tobacco (smoking/chewing), 22 had none of smoking and chewing tobacco habits, while none of them admitted for alcohol drinking. The scalp hair and whole blood samples were oxidized by 65% nitric acid and 30% hydrogen peroxide (2:1) ratio in microwave oven. The Zn in digests was determined by flame atomic absorption while Cd was determined by electrothermal atomic absorption spectrometry. The average Cd concentration was higher, while level of Zn was lower in the blood and scalp hair samples of mouth cancer patients as compared to referent subjects (p < .001). The male referents consuming tobacco (chewing and smoking) have high level of Cd in both their biological samples as compared to those not smoking or chewing tobacco (p < .012). The Cd/Zn ratio in both biological samples was found to be higher in patients than in referent subjects. PMID:20085960

Kazi, Tasneem Gul; Wadhwa, Sham Kumar; Afridi, Hassan Imran; Kazi, Naveed; Kandhro, Ghulam Abbas; Baig, Jameel Ahmed; Shah, Abdul Qadir; Kolachi, Nida Fatima; Khan, Sumaira

2010-01-19

169

The Male-to-Female Ratio and Multiple Sexual Partners: Multilevel Analysis with Patients from an STD Clinic  

PubMed Central

Sexual partner concurrency plays an important role in HIV and STD transmission. The shortage of African-American men may facilitate partner concurrency. This study evaluated whether the male-to-female ratio was associated with African-American participants' number of recent sexual partners, and whether this association differed by gender. Multilevel modeling was used to determine the influence of individual (i.e., gender) and population-level (i.e., sex ratio) variables on the number of recent sexual partners. African-American patients (N = 915; 52% male) were recruited from an STD clinic. Patients reported their number of sexual partners; the male-to-female ratio per census tract was obtained from the U.S. Census Bureau. There were fewer men than women in nearly all census tracts. The interaction between gender and the male-to-female ratio was significant. For men, there was no association between the sex ratio and their number of sexual partners. For women, as the sex ratio increased, their number of sexual partners increased; however, this association was driven by participants who reported trading sex. We found no evidence that fewer African-American men in a census tract was associated with men having more sexual partners.

Senn, Theresa E.; Carey, Michael P.; Vanable, Peter A.; Urban, Marguerite A.; Sliwinski, Martin J.

2008-01-01

170

Malignant fibrous histiocytoma of the breast in young male patient: a case report and a review of the literature.  

PubMed

MALIGNANT FIBROUS HISTIOCYTOMA (MFH) IS A FAIRLY COMMON TUMOR IN THE DEEP SOFT TISSUES: the most frequent primary sites are the lower (49%) and upper (19%) limbs, but it has been reported even in the retroperitoneum and abdomen (16%), while localization in the breast is extremely rare (1-2). Breast cancer is rarely seen in males, accounts for approximately 1% of all breast cancer, and the breast sarcomas constitute less than 1% of breast tumors in both sexes. In the review of the literature, this is the third male and first young male with MFH. Here, we present a 37-years-old male patient who is diagnosed to have malignant fibrous histiocytoma in a variant of pleomorphic fusiform cell localized in the left breast. Following the wide local excision, the patient was given an adjuvant 50?Gy of external radiotherapy. He remained alive and well after 42 months of followup. We believe that reporting such few cases would contribute to forming treatment algorithms of rare tumors. PMID:23573437

Kocak Uzel, Esengul; Figen, Metin; Bek, Tuba Tulin; Inanc, Kubilay; Onder, Senem; Kizilkaya, Hazim Orhan

2013-03-14

171

Malignant Fibrous Histiocytoma of the Breast in Young Male Patient: A Case Report and a Review of the Literature  

PubMed Central

Malignant Fibrous Histiocytoma (MFH) is a fairly common tumor in the deep soft tissues: the most frequent primary sites are the lower (49%) and upper (19%) limbs, but it has been reported even in the retroperitoneum and abdomen (16%), while localization in the breast is extremely rare (1-2). Breast cancer is rarely seen in males, accounts for approximately 1% of all breast cancer, and the breast sarcomas constitute less than 1% of breast tumors in both sexes. In the review of the literature, this is the third male and first young male with MFH. Here, we present a 37-years-old male patient who is diagnosed to have malignant fibrous histiocytoma in a variant of pleomorphic fusiform cell localized in the left breast. Following the wide local excision, the patient was given an adjuvant 50?Gy of external radiotherapy. He remained alive and well after 42 months of followup. We believe that reporting such few cases would contribute to forming treatment algorithms of rare tumors.

Kocak Uzel, Esengul; Figen, Metin; Bek, Tuba Tulin; Inanc, Kubilay; Onder, Senem; Kizilkaya, Hazim orhan

2013-01-01

172

Hyperemic peripheral red marrow in a patient with sickle cell anemia demonstrated on Tc99m labeled red blood cell venography  

Microsoft Academic Search

A 25-year-old gravid woman, homozygous for sickle cell anemia, with a history of recent deep venous thrombosis, was examined using Tc-99m labeled red blood cell venography for recurrent thrombosis. Although negative for thrombus, the study presented an unusual incidental finding: the patient's peripheral bone marrow was hyperemic in a distribution consistent with peripheral red bone marrow expansion. Such a pattern

RICHARD A. HEIDEN; ROBERTA C. LOCKO; THEODORE R. STENT

1991-01-01

173

Frequency of Chlamydia trachomatis among male patients with urethritis in northeast of Iran detected by polymerase chain reaction.  

PubMed

Planning for appropriate preventive measures against Chlamydia trachomatis, a common cause of sexually transmitted disease, requires knowledge of prevalence of infection so that interventions can be targeted in a cost-effective manner. This study was performed on 178 male patients presenting with urethritis in the Mashhad province to determine the prevalence of chlamydial infection in Northeast Iran. A cotton swab and first voided urine specimen were collected according to standard procedures. Polymerase chain reaction (PCR) tests were used for the detection of C. trachomatis in the specimens collected and the results were analyzed using SPSS program. Results showed that 10.6% of male patients in this group were infected with C. trachomatis. This study provides strong evidence that prevalence of Chlamydia in the Northeast Iran is high and suggests that Chlamydia screening as a routine part of STD investigations is highly necessary in this area. PMID:22382226

Ghazvini, Kiarash; Ahmadnia, Hassan; Ghanaat, Javad

2012-03-01

174

Short-Term Psychodynamic Psychotherapy in Patients with "Male Depression" Syndrome, Hopelessness, and Suicide Risk: A Pilot Study  

PubMed Central

Objectives and Methods. This was an observational study of the efficacy of short-term psychodynamic psychotherapy (STPP) in a sample of 35 (30 women and 5 men) patients with moderate-to-severe “male depression” (Gotland Scale for Male Depression (GSMD)???13) comorbid with unipolar mood disorder (dysthymia and major depression) or anxiety disorder. Outcome measures were GSMD and BHS (Beck Hopelessness Scale) score changes from baseline. Results. Patients had a strong response to STPP on the GSMD (estimated mean score change (± SE) = ?9.08 ± 2.74; P < 0.01; partial eta squared = 0.50), but not on the BHS (estimated mean score change (± SE) = ?0.92 ± 1.55; P = 0.57; partial eta squared ? = 0.03). BHS score changes were significantly associated with GSMD score changes (Pearson's r = 0.56; P < 0.001), even when controlling for the severity of hopelessness at the baseline (partial r = 0.62; P < 0.001). Conclusions. STPP proved to be effective in patients suffering from “male depression” although hopelessness was only marginally reduced by this treatment which points to the need to better understand how STPP can be involved in the reduction of suicide risk.

Angeletti, Gloria; Pompili, Maurizio; Innamorati, Marco; Santucci, Chiara; Savoja, Valeria; Goldblatt, Mark; Girardi, Paolo

2013-01-01

175

Clinical manifestations of Xq28 functional disomy involving MECP2 in one female and two male patients.  

PubMed

Subtelomeric imbalances are a frequent cause of cytogenetic abnormalities in patients with unexplained intellectual disability. Functional disomy of Xq28 involving the methyl-CpG-binding protein 2 gene (MECP2) has been observed mostly in subtelomeric duplications. We identified three patients with functional disomy of Xq28. A female patient showed an unbalanced translocation between 12q24.33 and Xq28. Two male patients showed an unbalanced translocation between Xq27.1- Yq11.22 and a recombinant X-chromosome containing duplicated material from Xq27.1 on Xp telomere, respectively. All three patients exhibited severe developmental delay, hypotonia, seizures, and distinctive facial features, including flat nasal bridge and hypertelorism. Additionally, brain magnetic resonance imaging (MRI) showed characteristic findings in each patient, including frontal dominant brain atrophy and hypoplasia of the corpus callosum, which are common findings in patients with functional disomies of Xq28 and interstitial duplications of Xq28, including MECP2. Brain MRI revealed a cystic lesion in the periventricular white matter in a patient, similar to our previous experience in patients with MECP2 duplication syndrome. Thus, white matter abnormalities may frequently be seen in cases of patients with additional MECP2 copies. © 2013 Wiley Periodicals, Inc. PMID:23704079

Shimada, Shino; Okamoto, Nobuhiko; Hirasawa, Kyoko; Yoshii, Keisuke; Tani, Yumi; Sugawara, Midori; Shimojima, Keiko; Osawa, Makiko; Yamamoto, Toshiyuki

2013-05-23

176

Two male patients with ring Y: definition of an interval in Yq contributing to Turner syndrome  

Microsoft Academic Search

Turner syndrome is thought to result from the haploinsufficiency of genes on the sex chromosomes, but these genes have not been identified yet. We describe two males with deleted ring Y chromosomes, one (TS) with full Turner syndrome and one (DM) without. TS has short stature, skeletal anomalies, lymphogenic obstruction, cardiovascular abnormalities, and miscellaneous features including pigmented naevi, antimongoloid slanting

Maria Tzancheva; Radka Kaneva; Philip Kumanov; Gareth Williams; Chris Tyler-Smith

1999-01-01

177

High Rate of Seropositivity of Chlamydia pneumoniae IgA in Male Patients with Nonalcoholic Steatohepatitis  

Microsoft Academic Search

The aim of this study was to investigate if there was any relationship between nonalcoholic steatohepatitis and the rate of Chlamydia pneumoniae seropositivity in a male population. Fifteen men with nonalcoholic steatohepatitis and 20 healthy men were enrolled in the study. The seropositivity rate of Chlamydia pneumoniae immunoglobulin A in the nonalcoholic steatohepatitis and control groups was 53.3 and 5%,

Fusun F. Bolukbas; Cengiz Bolukbas; Fadile Zeyrek; Mehmet Aslan; Halil I. Bahcecioglu; Ilyas Ozardali

2005-01-01

178

Risk Factors for Violent Behavior Among Incarcerated Male Psychiatric Patients: A Multimethod Approach  

Microsoft Academic Search

A multimethod approach that included demographic, criminal offense, drug use, neuropsychological, Rorschach, psychiatric diagnosis, and psychopathy characteristics was used to evaluate 131 incarcerated male psychiatric inpatients. Each criminal offense was ranked from nonviolent to severely violent, and participants were classified as having lifetime histories of either high or low violent behavior. Univariate analyses revealed 12 characteristics which independently discriminated inmates

Myla H. Young; Jerald Justice; Philip Erdberg

1999-01-01

179

OligoChip To Identify HLA-B*5101: Association Study in Male Patients with Behcet's Disease  

Microsoft Academic Search

To investigate the association of HLA-B*5101 and male Behcet's disease (BD). HLA-B51 antigens and HLA-B51 allele genotyping in 27 BD patients and 53 healthy controls were performed by complement-dependent microlymphocyte toxicity assay, OligoChip and PCR-sequence specific primer (SSP) method. HLA-B51 was found in 63% (17\\/27) of BD patients and in 15.1% (8\\/53) of controls < 0.0001, OR = 11.7, 95%

Zheng Yan; Sun Yuping; Wang Yunshan; Tian Yufeng; Sun Hongsheng

2009-01-01

180

Alcohol-related discussions during general medicine appointments of male VA patients who screen positive for at-risk drinking  

Microsoft Academic Search

OBJECTIVE: This study describes primary care discussions with patients who screened positive for at-risk drinking. In addition, discussions\\u000a about alcohol use from 2 clinic firms, one with a provider-prompting intervention, are compared.\\u000a \\u000a \\u000a DESIGN: Cross-sectional analyses of audiotaped appointments collected over 6 months.\\u000a \\u000a \\u000a \\u000a \\u000a PARTICIPANTS AND SETTING: Male patients in a VA general medicine clinic were eligible if they screened positive for

Katharine A. Bradley; Amee J. Epler; Kristen R. Bush; Jennifer L. Sporleder; Christopher W. Dunn; Nancy E. Cochran; Clarence H. Braddock; Mary B. McDonell; Stephan D. Fihn

2002-01-01

181

Scapular notching and osteophyte formation after reverse shoulder replacement: Radiological analysis of implant position in male and female patients.  

PubMed

This study provides recommendations on the position of the implant in reverse shoulder replacement in order to minimise scapular notching and osteophyte formation. Radiographs from 151 patients who underwent primary reverse shoulder replacement with a single prosthesis were analysed at a mean follow-up of 28.3 months (24 to 44) for notching, osteophytes, the position of the glenoid baseplate, the overhang of the glenosphere, and the prosthesis scapular neck angle (PSNA). A total of 20 patients (13.2%) had a notch (16 Grade 1 and four Grade 2) and 47 (31.1%) had an osteophyte. In patients without either notching or an osteophyte the baseplate was found to be positioned lower on the glenoid, with greater overhang of the glenosphere and a lower PSNA than those with notching and an osteophyte. Female patients had a higher rate of notching than males (13.3% vs 13.0%) but a lower rate of osteophyte formation (22.9% vs 50.0%), even though the baseplate was positioned significantly lower on the glenoid in females (p = 0.009) and each had a similar mean overhang of the glenosphere. Based on these findings we make recommendations on the placement of the implant in both male and female patients to avoid notching and osteophyte formation. PMID:23539706

Roche, C P; Marczuk, Y; Wright, T W; Flurin, P-H; Grey, S; Jones, R; Routman, H D; Gilot, G; Zuckerman, J D

2013-04-01

182

The Association Among Lipoprotein-associated Phospholipase A2 Levels, Total Antioxidant Capacity and Arousal in Male Patients with OSA  

PubMed Central

Background: The mechanisms of the increased cardiac and vascular events in patients with OSA are not well understood. Arousal which is an important component of OSA was associated with increased sympathetic activation and electrocardiographic changes which prone to arrhythmias. We planned to examine the association among arousal, circulating Lp-PLA2 and total antioxidant capacity in male patients with OSA. Methods: Fifty male patients with newly diagnosed OSA were enrolled the study. A full-night polysomnography was performed and arousal index was obtained. Lp-PLA2 concentrations were measured in serum samples with the PLAC Test. Total antioxidant capacity in patients was determined with Antioxidant Assay Kit. Results: Arousal was positively correlated with LP-PLA2 levels (r=0.43, p=0.002) and was negatively correlated with total antioxidant capacity (r= -0.29, p=0.04). Elevated LP-PLA2 levels and decreased total antioxidant activities were found in the highest arousal quartile compared with the lowest and 2nd quartiles (p=0.02, p=0.05, respectively). LP-PLA2 was an independently predictor of arousal index in regression model (?=0.357, p=0.002) Conclusions: This study demonstrated a moderate linear relationship between arousal and LP-PLA2 levels. Also, total antioxidant capacities were decreased in the higher arousal index. Based on the study result, the patients with higher arousal index may be prone to vascular events.

Bekci, Taha T.; Kayrak, Mehmet; Kiyici, Aysel; Maden, Emin; Ari, Hatem; Kaya, Zeynettin; Teke, Turgut; Akilli, Hakan

2011-01-01

183

Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction.  

PubMed

Korean ginseng and mountain ginseng (Panax ginseng CA Meyer) are important traditional herbal plants whose ginsenosides are generally accepted as serving to improve sexual functions, such as penile erection. We investigated the effects of tissue-cultured mountain ginseng extract (TMGE) on male patients with erectile dysfunction (ED). A double-blind, placebo-controlled study was conducted with 143 patients experiencing ED. Over the course of 8 weeks, one group took 1 000 mg of TMGE twice a day, and the other group took 1,000 mg of placebo twice a day. The effects of the TMGE and the placebo were analyzed using the Korean version of the International Index of Erectile Function (IIEF) questionnaire. A total of 86 patients completed 8 weeks of treatment. The scores on the five domains of the IIEF after medication were significantly higher than the baseline scores in the group treated with TMGE (P<0.05), whereas no significant improvement was observed in the placebo group (P>0.05). Erectile function and overall satisfaction scores after medication were significantly higher in the TMGE group than in the placebo group (P<0.05). Erectile function of patients in the TMGE-treated group significantly improved, suggesting that TMGE could be utilized for improving erectile function in male patients. PMID:19234482

Kim, Tae-Hwan; Jeon, Seung Hyun; Hahn, Eun-Joo; Paek, Kee-Yoeup; Park, Jong Kwan; Youn, Nae Young; Lee, Hyung-Lae

2009-02-23

184

The adult male voxel model ”Golem” segmented from whole-body CT patient data  

Microsoft Academic Search

This paper describes the construction of an adult male voxel model named ”Golem”1(1In Jewish tradition, Golem (Hebrew: shapeless matter) means an artificial human being endowed with life. There are several\\u000a legends about successful creations of the Golem. The most popular one is probably the Golem of Prague, created (and destroyed)\\u000a by Rabbi Yehuda Loev (1525–1609).) intended to be used for

Maria Zankl; Alfred Wittmann

2001-01-01

185

Androgen receptor polyglutamine tract length in Egyptian male breast cancer patients  

Microsoft Academic Search

Male Breast Cancer (MBC) is a rare disease in the U.S., accounting for less than 1% of all breast cancers. Rates of MBC in\\u000a Africa are more variable than in the U.S., therefore, understanding the risk factors involved in a population like Egypt can\\u000a clarify the nature of MBC. The polyglutamine tract (QT) is a variable region of the androgen

Samuel F. Gilbert; Amr S. Soliman; Maria Iniesta; Mohab Eissa; Ahmed Hablas; Ibrahim A. Seifeldin; Ashley Strahley; Mousumi Banerjee; Sofia D. Merajver

2011-01-01

186

Invasive Ductal Breast Carcinoma Underneath a Lipoma in a Male Patient  

PubMed Central

Male breast cancer is a rare malignancy and accounts for less than one percent of all cancers in men. The authors describe the case of a 76-year-old Caucasian man with invasive ductal breast carcinoma who presented with a common lipoma. This paper reviews the current literature on epidemiology, risk factors, etiology, different types of breast cancer, clinical presentation, imaging, diagnostic workup, and treatment.

Landero, James; Glick, Bradley P.

2012-01-01

187

Treatment of mastalgia with tamoxifen in male patients with liver cirrhosis: a randomized crossover study  

Microsoft Academic Search

OBJECTIVE:Mastalgia is occasionally found in patients with liver cirrhosis, especially in those receiving spironolactone for treatment of ascites. The pathogenesis is still unclear. Estrogen excess in cirrhotic patients and estrogenic effects of the spironolactone are possible leading causes. Treatment directed against the preponderance of estrogenic stimulation in these patients has never been investigated. This study was designed to investigate the

Chung-Pin Li; Fa-Yauh Lee; Shinn-Jang Hwang; Full-Young Chang; Han-Chieh Lin; Benjamin Ing-Tiau Kuo; Chi-Jen Chu; Shou-Dong Lee

2000-01-01

188

Human sperm and other seminal constituents in male infertile patients from arsenic and cadmium rich areas of Southern Assam.  

PubMed

In the present study the occurrence of two heavy metals, arsenic and cadmium, have been reported in the drinking water and seminal plasma of infertile male patients as compared to a control group. The study originated from a survey of geogenic groundwater contamination with the heavy metals arsenic and cadmium in Southern Assam, India as an increase in the incidence of male infertility was being reported from these areas. According to WHO protocol, patients with sperm concentration < 20 x 10(6)/ml were selected as cases (oligozoospermic and azoospermic), and those with > 20 x 10(6)/ml, without any extreme pathological disorders and having fathered a child within 1-2 years of marriage were the control (normozoospermic) group. The study reports an inverse relationship between total sperm count and heavy metal content in drinking water as well as seminal plasma of the subjects. Moreover, a high correlation between altered semenological parameters and lower expression of accessory sex gland markers like fructose, acid phosphatase, and neutral ?-glucosidase in the seminal plasma of patients is reported. The study also highlights significant differences of the sperm function parameters like hypo-osmotic swelling, acrosome reaction, and nuclear chromatin decondensation in the patient group as compared to controls. These findings are significant as they address a likely association between heavy metal stress and altered sperm function as well as seminal enzyme inhibition. PMID:23651453

Sengupta, Mahuya; Deb, Ishita; Sharma, Gauri Dutta; Kar, Kushal Kumar

2013-05-08

189

Changes in sexual function and gonadal axis hormones after switching to aripiprazole in male schizophrenia patients: a prospective pilot study.  

PubMed

Antipsychotic-induced sexual dysfunction is a common problem in patients with schizophrenia. The aim of the study was to investigate the effect of switching to aripiprazole on sexual dysfunction and the hypothalamic-pituitary-gonadal axis in male patients with schizophrenia. In this prospective, open-label study, the participants were 10 male schizophrenia patients treated with atypical antipsychotics, risperidone, amisulpride, and olanzapine. Before and after switching to aripiprazole, they were assessed on the Arizona Sexual Experience Scale, and hormonal levels were measured. Our results showed a significant improvement in the severity of sexual dysfunction, especially in 'ease of sexual arousal' and 'penile erection,' as measured by the Arizona Sexual Experience Scale total scores after switching to aripiprazole (?(2) = 12.45 and P = 0.002). The serum prolactin level decreased significantly after switching to aripiprazole (?(2) = 11.14 and P = 0.004), but the changes in the total testosterone level were not significant (?(2) = 4.75 and P = 0.93). Our results suggest that sexual dysfunction in schizophrenia patients seems to improve after switching to aripiprazole from other atypical antipsychotics (risperiodone, amisulpride, or olanzapine). This may be associated with a change in dopamine and serotonin transmissions and a decrease in the serum prolactin concentration. PMID:22407277

Jeong, Hyun-Ghang; Lee, Moon-Soo; Lee, Hwa-Young; Ko, Young-Hoon; Han, Changsu; Joe, Sook-Haeng

2012-07-01

190

Low-tech rehabilitation and management of a 64 year old male patient with acute idiopathic onset of costochondritis  

PubMed Central

Objective This study was conducted to discuss the treatment and management of a patient presenting with acute idiopathic costochondritis. Case 64 year old male patient presenting with acute anterior chest pain of one week duration. Treatment High-velocity low-amplitude thrust manipulation was used to the zygapophyseal joints of the thoracic spine, costotransverse, and costochondral joints involved. Acupuncture, ischemic compression, cross fibre friction massage techniques, and cryotherapy were utilized on the local area of pain. Specific exercise prescription (low tech rehabilitation) was also utilized. Improvement of pain reported on the Visual Analog Scale was noted with a complete resolution of the condition at the conclusion of treatment. No recurrences were reported on an eleven month follow up of the patient. Conclusion Conservative management, including manipulation and exercise prescription, may be beneficial in the treatment of benign costochondritis.

Hudes, Karen

2008-01-01

191

Clinical Features of Mumps Orchitis in Vaccinated Postpubertal Males: A Single-Center Series of 62 Patients  

PubMed Central

Purpose Although the measles-mumps-rubella vaccination covers most children against mumps in Korea, the development of mumps has been reported. However, the clinical manifestations of mumps orchitis in postpubertal vaccinated patients have never been investigated. Herein we report the clinical features of mumps orchitis in postpubertal vaccinated patients. Materials and Methods This study included a total of 62 postpubertal males who developed acute mumps orchitis from 2005 to 2010. The clinical manifestations such as the incubation period, febrile duration, and the mean duration of orchitis were retrospectively investigated. The laboratory and sonographic findings were also reviewed and compared with the features of previously reported cases of unvaccinated postpubertal mumps orchitis. Results The mean age of the 62 patients was 17.56 years (range, 15 to 29 years). All patients were serologically confirmed with acute mumps infection (positive immunoglobulin [Ig] M and negative or positive IgG). The mean incubation period was 5.39 days (range, 0 to 23 days), with a febrile duration of 1.8 days (range, 0.5 to 3 days), and a mean duration of orchitis of 4.96 days (range, 0 to 17 days). Sonography revealed unilateral orchitis in 58 patients (93.6%) and bilateral orchitis in only 6 (6.4%). Conclusions In our study, mumps orchitis in postpubertal vaccinated patients showed a relatively shorter febrile duration. In addition, less scrotal swelling and a lower incidence of bilaterality were found upon physical examination and ultrasonography. In the future, additional long-term follow-up is needed to determine the features of mumps orchitis in postpubertal vaccinated males, and an additional booster vaccination should be considered.

Tae, Bum Sik; Ham, Byeong Kuk; Kim, Jae Heon; Park, Jae Young

2012-01-01

192

Cigarette Smoking in Male Patients with Chronic Schizophrenia in a Chinese Population: Prevalence and Relationship to Clinical Phenotypes  

PubMed Central

The high prevalence of smoking in schizophrenia of European background may be related to smoking's reducing clinical symptoms and medication side effects. Because smoking prevalence and its associations with clinical phenotypes are less well characterized in Chinese than European patients with schizophrenia, we assessed these smoking behaviors using clinician-administered questionnaires and the Fagerstrom Test for Nicotine Dependence (FTND) in 776 Chinese male schizophrenia and 560 control subjects. Patients also were rated on the Positive and Negative Symptom Scale (PANSS), the Simpson and Angus Extrapyramidal Symptom Rating Scale (SAES), and the Abnormal Involuntary Movement Scale (AIMS). We found that the schizophrenia patients had a higher lifetime incidence of smoking (79% vs 63%), were more likely to be heavy smokers (61% vs 31%), and had lower smoking cessation rates (4% vs 9%) (all p<0.0001) than controls. Among the schizophrenia patients smoking prevalence increased with age, with the largest difference from controls in the age cohort of 55–75 years: 75% vs 46% (p<0.0001). Among the schizophrenia smokers 73% started to smoke before the onset of their illness by an average of 7.6 years. The patients with schizophrenia who were current smokers scored significantly lower on the PANSS negative symptom subscore (p<0.005), and on the SAES symptom scale (p<0.04; Bonferroni corrected p>0.05) than the non-smoking patients. These results suggest that Chinese males with schizophrenia smoke more frequently than the general population. Further, smokers with schizophrenia may display fewer negative symptoms and possibly less parkinsonism than non-smokers with schizophrenia.

Xiu, Mei Hong; He, Jincai; Cheng, Wei; Wu, Zhiwei; De Yang, Fu; Haile, Colin N.; Sun, Hongqiang; Lu, Lin; Kosten, Therese A.; Kosten, Thomas R.

2012-01-01

193

Examining the Affect of Chronic Schizophrenic Male Patients Towards 'Three Occupational Therapy Activities  

Microsoft Academic Search

This descriptive research paper attempts to examine the affect (feeling-mood) of a selected sampling of eight chronic schizophrenic patients towards some activities. These activities, commonly'utilized in the occupational therapy setting, included crafts (leather wrist bands), cooking (mini pizzas), and sensory integration (parachute play). The patients' ratings of the activities were measured via a semantic differential (SD). Through the SD, the

Karen A. Chun; Harriet A. Davidson

1988-01-01

194

Health-related Quality of Life and Mortality in Male Patients with Chronic Obstructive Pulmonary Disease  

Microsoft Academic Search

To assess whether generic and specific health-related quality of sures were associated with the survival of patients with COPD life (HRQL) are independently associated with total and specific in two clinical trials (5, 6). These associations were indepen- mortality in patients with chronic obstructive pulmonary disease dent of other clinical markers of severity, suggesting that (COPD), we followed until 1999

Antonia Domingo-Salvany; Rosa Lamarca; Montserrat Ferrer; Judith Garcia-Aymerich; Jordi Alonso; Miquel Felez; Ahmad Khalaf; Ramon M. Marrades; Eduard Monso; Joan Serra-Batlles

195

Sildenafil in the Treatment of Sexual Dysfunction in Spinal Cord–Injured Male Patients  

Microsoft Academic Search

Objectives: The aim of this study was to evaluate the efficacy and safety of sildenafil in the treatment of erectile dysfunction (ED) in spinal cord–injury (SCI) patients. Moreover, we looked for neurological conditions permitting therapeutic success and for the ideal dose needed to achieve sufficient erections.Methods: 41 SCI patients were prospectively examined. Sexual dysfunction was assessed by means of anamnesis,

Daniel Max Schmid; Brigitte Schurch; Dieter Hauri

2000-01-01

196

Acanthamoeba on Sabouraud's agar from a patient with keratitis  

PubMed Central

A 25-year-old transgender patient came with complaints of watery discharge, red eye and photophobia in the left eye since 2 days. The patient had a history of wearing colored contact lenses since 4 years and cleaning the lens with tap water. Culture of lenses on Mac Conkey and blood agar yielded Klebsiella pneumoniae and Pseudomonas aeruginosa. Sabouroud's agar showed yeast cells and double-walled cysts of Acanthamoeba species. On further incubation of Sabouroud's agar, the cysts transformed to trophozoites. Parallel results were obtained on tap water agar. The previous therapy of moxifloxacin was changed to local Neosporin application.

Baradkar, Vasant; Samal, Badhuli; Mali, Swapna A; Kulkarni, Ketaki; Shastri, Jayanthi

2011-01-01

197

Acanthamoeba on Sabouraud's agar from a patient with keratitis.  

PubMed

A 25-year-old transgender patient came with complaints of watery discharge, red eye and photophobia in the left eye since 2 days. The patient had a history of wearing colored contact lenses since 4 years and cleaning the lens with tap water. Culture of lenses on Mac Conkey and blood agar yielded Klebsiella pneumoniae and Pseudomonas aeruginosa. Sabouroud's agar showed yeast cells and double-walled cysts of Acanthamoeba species. On further incubation of Sabouroud's agar, the cysts transformed to trophozoites. Parallel results were obtained on tap water agar. The previous therapy of moxifloxacin was changed to local Neosporin application. PMID:23508061

Baradkar, Vasant; Samal, Badhuli; Mali, Swapna A; Kulkarni, Ketaki; Shastri, Jayanthi

2011-07-01

198

Effects of ergoreflex on respiration and other efferent effects in adult male patients with chronic obstructive pulmonary disease.  

PubMed

In COPD, overactivation of ergoreceptors may be a link between peripheral changes, sympathetic over activation and increased hemodynamic and ventilatory responses to exercise. The current study was undertaken to test the hypothesis that, ergoreflex in COPD patients is hyperactive and contributes to breathlessness and exercise limitation. The aim of study was to (1) demonstrate its hyperactivity in COPD (2). To record other efferent effects. Twenty stable COPD male patients aged 50 +/- 2.5 years and twenty healthy male subjects aged 48 +/- 3.5 years were studied under experimental and control groups. The ergoreflex contribution to cardio respiratory parameters was assessed by post-handgrip regional circulatory occlusion method (PH-RCO) and computed as the difference in heart rate and respiratory rate response between PH-RCO and control run without PH-RCO. Results were analyzed for significance between two groups by repeated measures ANOVA. COPD patients showed over activation of ergoreflex as compared to control subjects in terms of heart rate during sustained hand grip (SHG) exercise (117 +/- 1.22 versus 89 +/- 0.89) beats/min, recovery heart rate (p < 0.001), and respiratory rate during SHG (24 +/- 0.54 versus 19 +/- 03.24) breaths/min and recovery respiratory rate (p < 0.001). Degree of overactivation of ergoreflex was significant in COPD patients (p < 0.001). In COPD, overactivity of ergoreflex is associated with abnormal cardio respiratory reflex control. COPD patients showed overactivation of sympathetic nervous system as evidenced by heart rate changes during exercise and delayed recovery. PMID:23734433

Sharma, Shalini; Gupta, Rani; Nautiyal, Anupama; Sindhwani, Girish

199

A balanced t(10;15) translocation in a male patient with developmental language disorder.  

PubMed

We report the clinical and cytogenetic findings on a male child with developmental language disorder, no physical abnormalities, and a balanced t(10;15)(q24.1;q21.1) translocation. As the child's parents are unavailable for investigations, it is unclear whether the translocation is inherited or de novo. Fluorescence in situ hybridization (FISH) analyses were carried out using specific RP11-BAC clones mapping near 15q21.1 and 10q24.1 to refine the location of the breakpoints. The breakpoint on 15q21.1 interrupts the SEMA6D gene and the breakpoint on 10q24.1 is located between the ENTPD1 and CCNJ genes. The SEMA6D gene was further investigated in samples of individuals with developmental language disorders and controls; this investigation offered further evidence of the involvement of SEMA6D with developmental language disorders. PMID:22266071

Ercan-Sencicek, A Gulhan; Davis Wright, Nicole R; Sanders, Stephan J; Oakman, Nicole; Valdes, Lianna; Bakkaloglu, Betul; Doyle, Niamh; Yrigollen, Carolyn M; Morgan, Thomas M; Grigorenko, Elena L

2011-12-29

200

A balanced t(10;15) translocation in a male patient with developmental language disorder  

PubMed Central

We report the clinical and cytogenetic findings on a male child with developmental language disorder, no physical abnormalities, and a balanced t(10;15)(q24.1;q21.1) translocation. As the child’s parents are unavailable for investigations, it is unclear whether the translocation is inherited or de novo. Fluorescence in situ hybridization (FISH) analyses were carried out using specific RP11-BAC clones mapping near 15q21.1 and 10q24.1 to refine the location of the breakpoints. The breakpoint on 15q21.1 interrupts the SEMA6D gene and the breakpoint on 10q24.1 is located between the ENTPD1 and CCNJ genes. The SEMA6D gene was further investigated in samples of individuals with developmental language disorders and controls; this investigation offered further evidence of the involvement of SEMA6D with developmental language disorders.

Ercan-Sencicek, A. Gulhan; Davis Wright, Nicole R.; Sanders, Stephan J.; Oakman, Nicole; Valdes, Lianna; Bakkaloglu, Betul; Doyle, Niamh; Yrigollen, Carolyn M.; Morgan, Thomas M.; Grigorenko, Elena L.

2012-01-01

201

Sexual function in male patients after stroke—A follow-up study  

Microsoft Academic Search

A primary explorative survey was conducted regarding changes in sexual performance in 15 post-stroke patients admitted to our Center for rehabilitation. Average age was 49 years (range 31–64 years). Patients and partners were interviewed twice: as close as possible to admission and between 6–12 months after discharge. At interview they were questioned about desire, erection, orgasm (satisfaction) and overall sexual

R. Aloni; H. Ring; N. Rozenthul; J. Schwartz

1993-01-01

202

Mutation screening of RAD51C in male breast cancer patients  

Microsoft Academic Search

We read with great interest the paper by Akbari and colleagues [1] in a recent issue of Breast Cancer Research. Th e authors reported on the absence of RAD51C mutations in 454 patients with BRCA1\\/2-negative familial breast cancer\\/ovarian cancer (BC\\/OC). In the initial report by Meindl and colleagues [2], RAD51C mutations were identifi ed in 6 out of 480 patients

Valentina Silvestri; Piera Rizzolo; Mario Falchetti; Ines Zanna; Giovanna Masala; Domenico Palli; Laura Ottini

2011-01-01

203

Psychosocial Risk Profiles among Black Male Veterans Administration Patients Non-Adherent with Colorectal Cancer Screening  

PubMed Central

Objective This study identifies unique psychosocial characteristics among African American men that put the men at risk for non-adherence to colorectal cancer (CRC) screening (colonoscopy, sigmoidoscopy and FOBT). Subgroups sharing similar psychosocial characteristics may be targeted with specific intervention strategies aimed at increasing participation in screening, which could lead to increased early detection and decreased morbidity and mortality. Methods The male, African American veterans in our sample (n=260) had a mean age = 57.3 (SD=7.3). Our study employs latent class analysis (LCA), a quantitative-based, audience segmentation method to identify homogeneous subgroups of African American men with similar psychosocial characteristics related to CRC screening, potentially in need of different health information and intervention strategies. Latent class regression was used to examine the relationships among latent class structure and demographic characteristics. Results There were four psychosocial risk classes across the three screening tests. A significant subset of men had psychosocial characteristics indicative of willingness to be screened for each test (Colonscopy=21.8%, Sigmoidoscopy=31.5%, FOBT=10.8%), although they were currently non-adherent. Men who received a past screening test, had greater than a high school education, or were married were more likely to be represented in a latent class indicative of being prepared for getting colonoscopy or sigmoidoscopy. Socio-demographic variables were unrelated to FOBT latent class structure. Conclusions Segmenting our sample of male African American veterans based on psychosocial risk characteristics can inform the development of more precisely targeted interventions for African American men who are non-adherent for CRC screening.

BeLue, Rhonda; Menon, Usha; Kinney, Anita Y.; Szalacha, Laura A.

2011-01-01

204

HIV and STD Risk Behavior Among 18- to 25YearOld Men Released from U.S. Prisons: Provider Perspectives  

Microsoft Academic Search

Ninety-seven service providers, representing 83 agencies, were interviewed about sexual and drug use HIV\\/STD risk behaviors and their determinants among young men who have been released from prison. Providers believed that men frequently practiced sexual risk behavior, often in conjunction with substance use. Individual determinants of risk behavior primarily focused on “making up for lost time,” being a man, degree

David Wyatt Seal; Andrew D. Margolis; Jim Sosman; Deborah Kacanek; Diane Binson

2003-01-01

205

Anthropometric measurements of the external nose in 18-25-year-old Sistani and Baluch aborigine women in the southeast of Iran  

Microsoft Academic Search

The human nose differs in its anatomy and morphology between different racial and ethnic groups. The objective of this survey was to provide data for clinical plastics of the nose, medical aesthetics and cosmetology, anthropolo- gy, nationality study, and medical jurisprudence in Sistani (Fars) and Baluch aborigines in the southeast of Iran. The subjects participating in this study were 400

Z. Heidari; H. Mahmoudzadeh-Sagheb; T. Khammar; M. Khammar

206

Consuming cassava as a staple food places children 2-5 years old at risk for inadequate protein intake, an observational study in Kenya and Nigeria  

PubMed Central

Background Inadequate protein intake is known to be deleterious in animals. Using WHO consensus documents for human nutrient requirements, the protein:energy ratio (P:E) of an adequate diet is > 5%. Cassava has a very low protein content. This study tested the hypothesis that Nigerian and Kenyan children consuming cassava as their staple food are at greater risk for inadequate dietary protein intake than those children who consume less cassava. Methods A 24 hour dietary recall was used to determine the food and nutrient intake of 656 Nigerian and 449 Kenyan children aged 2-5 years residing in areas where cassava is a staple food. Anthropometric measurements were conducted. Diets were scored for diversity using a 12 point score. Pearson's Correlation Coefficients were calculated to relate the fraction of dietary energy obtained from cassava with protein intake, P:E, and dietary diversity. Results The fraction of dietary energy obtained from cassava was > 25% in 35% of Nigerian children and 89% of Kenyan children. The mean dietary diversity score was 4.0 in Nigerian children and 4.5 in Kenyan children, although the mean number of different foods consumed on the survey day in Nigeria was greater than Kenya, 7.0 compared to 4.6. 13% of Nigerian and 53% of Kenyan children surveyed had inadequate protein intake. The fraction of dietary energy derived from cassava was negatively correlated with protein intake, P:E, and dietary diversity. Height-for age z score was directly associated with protein intake and negatively associated with cassava consumption using regression modeling that controlled for energy and zinc intake. Conclusions Inadequate protein intake was found in the diets of Nigerian and Kenyan children consuming cassava as a staple food. Inadequate dietary protein intake is associated with stunting in this population. Interventions to increase protein intake in this vulnerable population should be the focus of future work.

2010-01-01

207

Handwriting Difficulties and Their Assessment in Young Adults with DCD: Extension of the DASH for 17-to 25-Year-Olds  

Microsoft Academic Search

Handwriting difficulties are common in children with developmental coordination disorder (DCD) and frequently continue into\\u000a adulthood. In spite of increased computer use, handwriting remains an essential everyday life skill. The Detailed Assessment\\u000a of Speed of Handwriting (DASH) provides an objective measure of handwriting performance for students aged 9–16 years. No equivalent\\u000a test for adults exists. The aim of this study is

Anna L. BarnettSheila; Sheila E. Henderson; Beverly Scheib; Joerg Schulz

208

Implementation and impact of a meningococcal C conjugate vaccination program in 13- to 25-year-old individuals in Galicia, Spain.  

PubMed

BACKGROUND: In response to increased case numbers of meningococcal group C disease, catch-up vaccination strategies have been shown to be successful. This paper describes the results of a repeat vaccination program in Galicia, Spain, and the strategy used for it. METHODS AND RESULTS: Three vaccination waves were performed: first, in 1996/1997 with a meningococcal group A and C polysaccharide vaccine in individuals aged 18 months to 19 years; second, in 2000 with a conjugate serogroup C polysaccharide vaccine in children born since 1993 and all children and adolescents up to 19 years not previously vaccinated; third, a campaign in 2006 that became necessary because of the development of a new Neisseria strain and an increase in both the incidence and lethality of meningococcal C disease. The conjugate vaccine de-O-acetylated group C meningococcal polysaccharide coupled to tetanus toxoid was used (GCMP-TT; brand name, NeisVac-C). Results: Applying a strategy based on model calculations derived from the UK setting and focusing on a population aged 13-25 years, including students, employees of companies, and underage individuals, a total of 286,000 subjects were vaccinated, resulting in global vaccination coverage of 82.2% (all age groups over 74%). Only 17 adverse events in 17 individuals were reported, which all were mild. Incidence of meningococcal disease serogroup C by season was reduced from 0.84 cases per 100,000 in 2004/05 to 0.76 cases per 100,000 in 2005/2006 to 0.18/100,000 in 2007/08. In parallel, mortality was also decreased from 8 cases during 2005/06 (0.29 per 100,000) to 1 case in 2007/2008 (0.03 per 100,000). No cases of breakthrough disease occurred in the vaccinated population. CONCLUSION: In Galicia, a series of vaccination campaigns, particularly focusing on high-risk groups, has shown high effectiveness, with a marked reduction in the disease incidence in the vaccination cohort accompanied by a relevant reduction in the overall population. PMID:21957332

Rego Romero, Elena; Nartallo Penas, Victoria; Taboada Rodríguez, José Antonio; Malvar Pintos, Alberto; Hervada Vidal, Xurxo; López Pimentel, María José

2011-03-16

209

Human papillomavirus 16/18 AS04-adjuvanted cervical cancer vaccine: immunogenicity and safety in 15-25 years old healthy Korean women  

PubMed Central

Objective The study assessed the immunogenicity and safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted cervical cancer vaccine in healthy Korean women aged 15-25 years. Methods Phase IIIB, double-blind, randomised (2:1), multi-centre trial was conducted in Korea from June 2007 to March 2008. The study enrolled 225 women in the HPV (N=149) and placebo (N=76) groups who received three doses of HPV-16/18 AS04-adjuvanted vaccine or placebo (aluminium hydroxide) administered intramuscularly at 0, 1, and 6 months and were followed until one month post-dose 3. Serum samples were collected pre-vaccination and one month post-dose 3. Safety and reactogenicity data were collected throughout. Results In this trial, 208 women completed the study (141 in HPV group; 67 in placebo group). At month 7, all initially seronegative women had seroconverted for HPV-16 and HPV-18 antibodies with anti-HPV-16 and anti-HPV-18 geometric mean titres of 9,351.4 El.U/mL (95% CI, 8,145.5 to 10,735.8) and 4204.1 El.U/mL (95% CI, 3,626.5 to 4,873.6), respectively. Initially seropositive women showed similar increase in geometric mean titre levels. Compliance to the three dose vaccination course was 95.3% in HPV and 89.5% in placebo group. Solicited local (pain) and general (fatigue, myalgia or headache) symptoms were commonly reported in both groups. Three serious adverse events were reported (two in HPV group; one in placebo group), all unrelated to vaccination by the investigator; all recovered. Conclusion The HPV-16/18 AS04-adjuvanted vaccine was highly immunogenic with a clinically acceptable safety profile in Korean women. This study was in line with previous global studies in Europe, North America, and Brazil. (ClinicalTrials.gov number, NCT 00485732.)

Kim, Seung Cheol; Song, Yong Sang; Kim, Young-Tae; Kim, Young Tak; Ryu, Ki-Sung; Gunapalaiah, Bhavyashree; Bi, Dan; Bock, Hans L

2011-01-01

210

Evolution of phenotypes in adult male patients with X-linked adrenoleukodystrophy.  

PubMed

Our objective was to study the phenotype evolution of X-linked adrenoleukodystrophy (X-ALD) and the relation between axonal degeneration and cerebral demyelination. Although different X-ALD phenotypes are recognized, little is known about their evolution. Neuropathological and electrophysiological studies have shown that X-ALD is a disease with mixed features of axonal degeneration, leading to myeloneuropathy, and a severe inflammatory reaction in the cerebral white matter, resulting in demyelination. Retrospectively, 129 men with X-ALD were studied who were 1) at least 20 years presently or at the time of death, and 2) regularly monitored. Phenotype assignments were made at diagnosis and at present, or at death, using medical history and findings of neurological examination. Handicap was studied with the modified Rankin scale, and cerebral abnormalities with the X-ALD MRI severity (Loes) score. The mean follow-up interval was 10.1 +/- 5.0 years. Among 32 patients neurologically asymptomatic at diagnosis, 16 (50%) developed neurological deficits. Among 68 adrenomyeloneuropathy (AMN) patients initially without clinical brain involvement, 13 (19%) additionally developed cerebral demyelination. In a subset of 60 AMN patients, a moderate handicap evolved over a period of 16.2 +/- 8.9 years. Among 13 AMN patients with additional definite or probable cerebral involvement at diagnosis, eight died and one remained in a vegetative state. Most of the 16 patients with the cerebral phenotypes deteriorated. There is a high risk for adult neurologically asymptomatic patients to develop neurological deficits and for AMN patients to develop cerebral demyelination. Axonal degeneration and cerebral demyelination emerge in X-ALD independently of each other. This may have implications for the phenotype classification, the search for modifying factors, and the development and evaluation of new therapies. PMID:11220738

van Geel, B M; Bezman, L; Loes, D J; Moser, H W; Raymond, G V

2001-02-01

211

Does the peak torque of the hamstring and quadriceps muscles affect the knee laxity measurements in male patients with anterior cruciate ligament rupture?  

Microsoft Academic Search

The aim of the study was to examine whether the peak torque of the hamstring and quadriceps muscles affects the anterior\\u000a knee laxity measurements in male patients. The study comprised 45 male patients who had a chronic unilateral anterior cruciate\\u000a ligament (ACL) rupture. Preoperatively, one experienced physiotherapist performed all the KT-1000 examinations. The anterior\\u000a displacement was registered at 89 Newton.

Ninni Sernert; Jüri Kartus; Kristina Köhler; Lars Ejerhed; Sveinbjörn Brandsson; Jon Karlsson

2000-01-01

212

A prospective comparison of bone-patellar tendon-bone and hamstring tendon grafts for anterior cruciate ligament reconstruction in male patients  

Microsoft Academic Search

The aim of the study was to compare the results after arthroscopic anterior cruciate ligament (ACL) reconstruction using central-third,\\u000a bone-patellar tendon-bone (BPTB Group) (n = 45) and four-strand semitendinosus\\/gracilis (ST\\/G Group) (n = 78) autografts in male patients. The type of study is non-randomised, prospective consecutive series. A consecutive series\\u000a of 126 male patients, all with unilateral ACL ruptures, was included in the study.

Gauti Laxdal; Ninni Sernert; Lars Ejerhed; Jon Karlsson; Jüri T. Kartus

2007-01-01

213

Long-term efficacy of AMS 800 artificial urinary sphincter in male patients with urodynamic stress incontinence due to spinal cord lesion  

Microsoft Academic Search

Study design:Retrospective analysis.Objectives:To evaluate long-term efficacy and complications of AMS 800 (American Medical Systems®) artificial urinary sphincter (AUS) in treatment of urodynamic stress incontinence (USI) in male patients with spinal cord lesion (SCL).Setting:London Spinal Injuries Unit, Stanmore, UK and Institute of Urology and Nephrology, London, UK.Patients and methods:A retrospective analysis identified nine males with SCL (five thoracic, three lumbar, one

P Patki; R Hamid; P J R Shah; M Craggs

2006-01-01

214

Acoustic analysis of tracheo-oesophageal voice in male total laryngectomy patients  

PubMed Central

INTRODUCTION The aim of this study was to test the null hypothesis that voice parameters of post-laryngectomy patients using tracheo-oesophageal (TO) prosthetic valves are similar to those of normal laryngeal subjects. METHODS Thirty total laryngectomy patients and thirty normal controls were subjected to acoustic analysis of single voice recordings using a sustained vowel. Acoustic parameters including fundamental frequency, jitter, shimmer, harmonics-to-noise ratio and maximum phonation time were analysed. RESULTS Poorer values were found as well as larger variability for all the voice parameters for the total laryngectomy patients using TO voice compared with those of normal subjects. There were statistically significant differences (p<0.05) for all studied parameters between the TO and normal speech. CONCLUSIONS Alaryngeal speech with TO voice prosthesis is not yet comparable to laryngeal speech.

Deore, N; Datta, S; Dwivedi, RC; Palav, R; Shah, R; Sayed, SI; Jagde, M; Kazi, R

2011-01-01

215

Clinical value of mean platelet volume for impaired cardiopulmonary function in very old male patients with chronic obstructive pulmonary disease.  

PubMed

High mean platelet volume (MPV) is a marker of platelet activation. The present study was designed to test if high MPV is associated with impaired cardiopulmonary function in patients with COPD. One hundred and sixteen male outpatients (mean age, 86.03±4.29 years) with COPD were recruited. Blood samples were collected for measurements of MPV and other laboratory data. Lung function and cardiac function were also assessed. Multiple linear regression analyses revealed that MPV was negatively correlated with left ventricular ejection fraction (?=-0.252, p=0.008) and the predicted value of forced expiratory volume in one second (FEV(1)% predicted) (?=-0.384, p=0.0001), whereas MPV was positively correlated with right pulmonary arterial diameter (?=0.311, p=0.005). The present study showed an association between high MPV, a marker of platelet activation, and impaired cardiopulmonary function in elderly COPD male patients. High MPV may be regarded as an early predictive marker of impaired cardiopulmonary function in COPD. PMID:22018467

Cui, Hua; Liu, Lin; Wei, Zhimin; Wang, Delong; Hu, Yixin; Hu, Guoliang; Fan, Li

2011-10-20

216

Prolactin and estradiol serum levels in unmedicated male paranoid schizophrenia patients  

Microsoft Academic Search

There is evidence for the involvement of the endocrine system in schizophrenia. This involment was widely investigated in female patients. In the current study, we examined prolactin and estradiol serum levels in hospitalized unmedicated men with first-episode and recurrent schizophrenia and then tested possible correlation with various subtypes of the disease. In addition, the estradiol and prolactin levels were compared

Michael Segal; Avi Avital; Severina Berstein; Andrei Derevenski; Sergio Sandbank; Abraham Weizman

2006-01-01

217

Urihesive: a new aid in the management of urinary incontinence in male paraplegic patients  

Microsoft Academic Search

Our past practice with incontinent paraplegic patients has been to attach to the penis the sheath incorporated in urinary drainage devices by means of Elastoplast tape. Frequent development of skin lesions due to local irritation, and the necessity to wind Elastoplast tightly around the penis, which may produce urethral diverticula, has led us to use Urihesive to attach the sheath

J de Leval; J C Louis

1978-01-01

218

Decreased response inhibition in middle-aged male patients with type 2 diabetes  

PubMed Central

Background This study was performed to examine whether patients with type 2 diabetes have cognitive deficits associated with the prefrontal cortex (PFC). Methods Twenty-seven middle-aged patients with newly diagnosed type 2 diabetes and 27 healthy controls underwent physical measurements and neuropsychological tasks. Response inhibition, reward prediction, and executive function were assessed by the Go/NoGo task, the reversal and extinction tasks, and the Wisconsin Card Sorting Test (WCST). To examine the interactions of being overweight with diabetes on cognitive performance, performance data were analysed by two-way ANCOVA with diabetes and overweight as factors and age as a covariate. Results Patients with type 2 diabetes showed significantly decreased response inhibition in the Go/NoGo task (discriminability index: P = 0.001). There was an interaction of being overweight with diabetes on reaction time in the Go trials of the Go/NoGo task (P = 0.009). Being overweight was related to retained responses to the presentiment of reward in the extinction task (P = 0.029). The four groups showed normal cognitive performance in the WCST. Conclusions Our results showed that middle-aged, newly diagnosed and medication-free patients with type 2 diabetes have a particular neuropsychological deficit in inhibitory control of impulsive response, which is an independent effect of diabetes apart from being overweight.

2010-01-01

219

Prolactin and estradiol serum levels in unmedicated male paranoid schizophrenia patients  

Microsoft Academic Search

There is evidence for the involvement of the endocrine system in schizophrenia. This involment was widely investigated in female patients.In the current study, we examined prolactin and estradiol serum levels in hospitalized unmedicated men with first-episode and recurrent schizophrenia and then tested possible correlation with various subtypes of the disease. In addition, the estradiol and prolactin levels were compared with

Michael Segal; Avi Avital; Severina Berstein; Andrei Derevenski; Sergio Sandbank; Abraham Weizman

2007-01-01

220

Hyperbaric Oxygen Therapy in the Treatment of Fournier's Disease in 11 Male Patients  

Microsoft Academic Search

PurposeOptimal tissue oxygenation, as obtained by hyperbaric oxygen therapy, potentiates or restores the host's bactericidal mechanisms and wound healing activity in patients afflicted by serious synergeic aerobic and anaerobic infections of the cutaneous and subcutaneous tissues. Furthermore, hyperbaric oxygen therapy has a direct toxic effect on anaerobic bacteria. We describe our experience with hyperbaric oxygen therapy in the treatment of

R. Pizzorno; F. Bonini; A. Donelli; R. Stubinski; M. Medica; G. Carmignani

1997-01-01

221

Second cancers in patients with male breast cancer: a literature review  

Microsoft Academic Search

Purpose  The risk of second malignancies among female breast cancer patients has been studied for decades. In contrast, very little\\u000a is known about second primary tumors in men. Risk factors for breast cancer in men, including genetic, hormonal and environmental\\u000a factors, provide parallels to the etiology of breast cancer in women. This review considers the literature related to the\\u000a risk of

Tal Grenader; Anthony Goldberg; Linda Shavit

2008-01-01

222

Steroid 5?-Reductase 1 Polymorphisms and Testosterone\\/Dihydrotestosterone Ratio in Male Patients with Hypospadias  

Microsoft Academic Search

Background\\/Aim: Defects in the steroid 5?-reductase type 2 (SRD5A2) activity cause decreased formation of dihydrotestosterone (DHT) from testosterone (T), resulting in defective masculinization of external genitalia; the T\\/DHT ratio is increased. We investigated 10 patients with elevated T\\/DHT ratios in whom mutations in the SRD5A2 and AR genes had been excluded to find out whether structural alterations of the SRD5A1

Antje Tria; Olaf Hiort; Gernot H. G. Sinnecker

2004-01-01

223

Study of the effect of iron overload on the function of endocrine glands in male thalassemia patients  

PubMed Central

Background: Iron overload is an important issue in the state of thalassemic patients due to the harmful effect of high concentration of iron deposited in different tissues in human body including endocrine glands. In the present work, an attempt is carried out to estimate the effect of iron overload in thalassemic patients on the function of endocrine glands through the estimation of their ability to secrete adequate amounts of certain hormones. Materials and Methods: Seventy eight male children with beta-thalassemia, in the age-group of 4–11 years, were enrolled for this research. These children were being treated with frequent transfusions and long-term iron chelation therapy. Thirty age and sex matched children without thalassemia constituted the control group. Ferritin and different hormones were estimated by ELISA technique. Results: The results showed a mild reduction in the function of endocrine glands through the decrease in the level of some hormones. These changes due mainly to the hypoxia and precipitation of iron in certain glands and overlapping with the synthesis or secretion of the hormones. Conclusion: There is a different hormonal disturbances in beta thalassemia patients. Reduction of total body iron store is an important goal of the treatment of thalassemia and measuring the hormones concentration is necessary for the follow up of the thalassemic patients especially during puberty.

Abdulzahra, Mohammed Saied; Al-Hakeim, Hussein Kadhem; Ridha, Mahdi Muhammed

2011-01-01

224

X-Linked adrenoleukodystrophy is a frequent cause of idiopathic Addison`s disease in young adult male patients  

SciTech Connect

X-Linked adrenoleukodystrophy (ALD) is a genetic disease associated with demyelination of the central nervous system, adrenal insufficiency, and accumulation of very long chain fatty acids in tissue and body fluids. ALD is due to mutation of a gene located in Xq28 that encodes a peroxisomal transporter protein of unknown function. The most common phenotype of ALD is the cerebral form (45%) that develops in boys between 5-12 yr. Adrenomyeloneuropathy (AMN) involves the spinal cord and peripheral nerves in young adults (35%). Adrenal insufficiency (Addison`s disease) is frequently associated with AMN or cerebral ALD and may remain the only clinical expression of ALD (8% of cases). The prevalence of ALD among adults with Addison`s disease remains unknown. To evaluate this prevalence, we performed biochemical analysis of very long chain fatty acids in 14 male patients (age ranging from 12-45 yr at diagnosis) previously diagnosed as having primary idiopathic adrenocortical insufficiency. In 5 of 14 patients (35%), elevated plasma concentrations of very long chain fatty acids were detected. None of these patients had adrenocortical antibodies. By electrophysiological tests and magnetic resonance imaging it was determined that two patients had cerebral ALD, one had adrenomyeloneuropathy with cerebral involvement, and two had preclinical AMN. Our data support the hypothesis that ALD is a frequent cause of idiopathic Addison`s disease in children and adults. 30 refs., 5 tabs.

Laureti, S.; Casucci, G.; Santeusanio, F. [Univ. of Perugia (Italy)] [and others

1996-02-01

225

Elevated plasma level of visfatin/pre-b cell colony-enhancing factor in male oral squamous cell carcinoma patients  

PubMed Central

Objectives: Visfatin, also known as nicotiamide phosphoribosyltransferase or pre-B cell colony enhancing factor, is a pro-inflammatory cytokine whose serum level is increased in various cancers. In this study, we investigated whether plasma visfatin levels were altered in patients with oral squamous cell carcinoma (OSCC). The relationship between plasma visfatin levels and the pretreatment hematologic profile was also explored. Study Design: Plasma visfatin concentrations were measured through ELISA in OSCC patients and control subjects. A total of 51 patients with OSCC and 57 age- and body mass index (BMI)-matched control subjects were studied. All study subjects were male. Results: Plasma visfatin was found to be elevated in patients with OSCC (7.0 ± 4.5 vs. 4.8 ± 1.9 ng/ml, p = 0.002). Multiple logistic regression analysis revealed visfatin as an independent association factor for OSCC, even after full adjustment of known biomarkers. Visfatin level was significantly correlated with white blood cell (WBC) count, neutrophil count, and hematocrit (all p < 0.05). In addition, WBC count, neutrophil count, and visfatin gradually increased with stage progression, and hematocrit gradually decreased with stage progression (all p < 0.05). Conclusion: Increased plasma visfatin levels were associated with OSCC, independent of risk factors, and were correlated with inflammatory biomarkers. These data suggest that visfatin may act through inflammatory reactions to play an important role in the pathogenesis of OSCC. Key words:Visfatin; oral squamous cell carcinomas; white blood cell count; neutrophil count.

Yu-Duan, Tsai; Chao-Ping, Wang; Chih-Yu, Chen; Li-Wen, Lin; Tsun-Mei, Lin; Chia-Chang, Hsu; Fu-Mei, Chung; Hsien-Chang, Lin; Hsia-Fen, Hsu; Yau-Jiunn, Lee

2013-01-01

226

Clinical features and polysomnographic findings in greek male patients with obstructive sleep apnea syndrome: differences regarding the age.  

PubMed

Background-Aim. Although sleep disturbance is a common complaint among patients of all ages, research suggests that older adults are particularly vulnerable. The aim of this retrospective study was to elucidate the influence of age on clinical characteristics and polysomnographic findings of obstructive sleep apnea syndrome (OSAS) between elderly and younger male patients in a Greek population. Methods. 697 male patients with OSAS were examined from December 2001 to August 2011. All subjects underwent an attended overnight polysomnography (PSG). They were divided into two groups: young and middle-aged (<65 years old) and elderly (?65 years old). We evaluated the severity of OSAS, based on apnea-hypopnea index (AHI), and the duration of apnea-hypopnea events, the duration of hypoxemia during total sleep time (TST) and during REM and NREM sleep, and the oxygen saturation in REM and in NREM sleep. Results. PSG studies showed that elderly group had significant higher duration of apnea-hypopnea events, longer hypoxemia in TST and in NREM sleep, as well as lower oxygen saturation in REM and NREM sleep than the younger group. Otherwise, significant correlation between BMI and neck circumference with AHI was observed in both groups. Conclusions. The higher percentages of hypoxemia during sleep and longer duration of apnea-hypopnea events that were observed in the elderly group might be explained by increased propensity for pharyngeal collapse and increased deposition of parapharyngeal fat, which are associated with aging. Another factor that could explain these findings might be a decreased partial arterial pressure of oxygen (PaO2) due to age-related changes in the respiratory system. PMID:23470883

George, Efremidis; Katerina, Varela; Maria, Spyropoulou; Lambros, Beroukas; Konstantina, Nikoloutsou; Dimitrios, Georgopoulos

2012-01-23

227

Prosthetic rehabilitation of a Crouzon patient: A case report  

PubMed Central

Crouzon syndrome is a rare genetic disorder, which can be defined as a variation of craniofacial dysostosis caused by the premature obliteration and ossification of two or more sutures. The growth pattern results in pseudoprognathism and malocclusions including an overcrowded or a widely spaced dentition. Specifically maxillary arch is narrow, high, and V-shaped. Cleft palate and bifid uvula are other possible features in the oral cavity. This report describes a non-surgical treatment model to overcome the remaining significant Class III intermaxillary relation and excessive tooth loss to recover function and aesthetics for a 25-year-old Crouzon patient.

Kurt, Hanefi; Gencel, Burc; Kader, Aydin C.

2010-01-01

228

Clinical characteristics of familial versus sporadic alcoholism in a sample of male and female patients.  

PubMed

Presence of a family history of alcoholism may predict clinical characteristics in affected subjects, such as an earlier age at onset. More frequent and severe social maladjustment and somatic complications are also regularly cited for familial alcoholism, although subject to many other confusing factors. We analysed the clinical specificities of 79 alcohol-dependent inpatients according to the absence versus presence of family history of alcoholism. Patients were evaluated for lifetime psychiatric morbidity with the Diagnostic Interview for Genetic Studies (DIGS), for somatic complications with a systematic screening list, and first-degree relatives (N = 428) were assessed with the Family Inventory Schedule and Criteria (FISC). Age at onset and social complications were predicting familial versus sporadic alcoholism, even when considering censored data and/or interaction between variables. But differences became non-significant when excluding patients with antisocial personality. If age at onset effectively appears to be the most informative characteristic for predicting familial versus sporadic alcoholism, it seems that it may be necessary in future studies to systematically take into account antisocial personality diagnosis, because of a probable contamination. PMID:11353592

Limosin, F; Gorwood, P; Adès, J

2001-04-01

229

Male catheterization.  

PubMed

The insertion of catheters into male emergency patients is fairly common practice and is associated with a worryingly high rate of infection. Everyday pressures within the department, along with the added stress of resuscitation can result in inappropriately trained or skilled staff undertaking this procedure. The issue of gender and whether female nurses should catheterize male patients may also affect this vulnerable group of patients. Acquiring the psychomotor skills of inserting a urethral catheter is only one part of preparation for practice. Emergency nurses must know when and when not to resort to catheterization. Choosing the type and size of catheter requires careful judgment. What will you do if insertion proves difficult? Prevention of infection is of paramount importance and there are an increasing number of evidence-based sources of information, which are crucial to formulating procedures and informing every day practice. In the pressured surroundings of A&E departments, it is easy to ignore the vulnerability of men requiring catheterization, both from a physical and psychological point of view. Making the effort to explain the procedure, listen to questions and concerns and record relevant details in the notes, will take only a few extra moments. There is no doubt that urinary catheterization is not without complications. It is associated with significant morbidity and occasionally, mortality. PMID:11855766

Hadfield-Law, L

2001-10-01

230

Myocardial Hydatid Cyst in a Young Male Patient Who Feeds Pet at Home: A Case Report  

PubMed Central

Hydatid cysts are rarely asymptomatic depending on their location. Complaints may be only relevant due to secondary problems. This paper presents a case report of a myocardial hydatid cyst which was totally excised under cardiopulmonary bypass operation with median sternotomy. Patient was admitted to the hospital with complaint of atypical chest pain in pungent manner together with shortness of breath. Various methods are used for diagnosis. However, echocardiography and computerized tomography with contrast are usually enough for definitive diagnosis and for deciding the strategy of operation. Curative excision must be performed. Extra care should be provided during the operation in order to prevent contamination. Postoperative appropriate antibiotherapy must be administered. Environment should be changed, and infrastructure must be improved in order to prevent further recurrences.

Demirtas, Sinan; Yavuz, Celal; Basyigit, Ismail; Firat, Ugur; Caliskan, Ahmet

2012-01-01

231

Social Anxiety and HIV Transmission Risk among HIV-Seropositive Male Patients  

PubMed Central

Abstract The role of psychological factors in predicting HIV sexual transmission risk behavior is increasingly of interest in prevention research. Social anxiety, or anxiety about being evaluated in interpersonal situations, is associated with unprotected insertive anal intercourse among young men who have sex with men (MSM) and with other behavioral risk factors for unprotected intercourse, such as depression, smoking, alcohol use, and drug use. Social anxiety may be especially relevant in understanding HIV risk among HIV-seropositive men, given its stronger association with unprotected insertive than with receptive anal intercourse. In the present study, for which participants were recruited between October 2002 and May 2003, HIV-positive men attending regularly scheduled primary care medical appointments at a community HIV clinic were approached by research personnel and informed about the study topic and procedures. Ninety percent of patients approached agreed to participate, resulting in a sample of 206 patients. The sample was primarily African American, unemployed, of low educational level, and 95% of the sample had an AIDS diagnosis. The present study replicated and extended previous research from community samples by demonstrating an association between social anxiety and unprotected insertive anal intercourse with non-HIV-positive partners in a clinical sample of HIV-positive MSM and men who have sex with women (MSW). This association was maintained controlling for depression, smoking, and club drug use. Social anxiety is a relatively robust risk factor for unprotected insertive anal intercourse among MSM. Future work should examine the mechanisms by which social anxiety is associated with sexual risk among MSM.

James, Carolyn A.; Purcell, David W.; Farber, Eugene

2008-01-01

232

Naftopidil vs silodosin in medical expulsive therapy for ureteral stones: a randomized controlled study in Japanese male patients.  

PubMed

The aim of the present study was to compare the efficacy of the selective ?(1D) -adrenoceptor antagonist naftopidil and the selective ?(1A) -adrenoceptor antagonist silodosin (as an example) in the management of ureteral stones in Japanese male patients. A total of 74 patients with symptomatic ? 10 mm ureteral stones were enrolled in a prospective study and randomized into two groups: Group 1 received 50 mg naftopidil daily, whereas Group 2 received 8 mg silodosin daily. Patients were followed-up for up to 6 weeks. The primary endpoint was stone expulsion rate and secondary endpoints were stone expulsion time, the rate of interventions, such as transurethral ureterolithotripsy, extracorporeal shock wave lithotripsy, or ureteral stenting, and side effects. There were no significant differences between the two groups with respect to age, stone size, and location. The stone expulsion rate was 61% and 84% in the naftopidil and silodosin groups, respectively (P = 0.038). No significant differences were noted in stone expulsion time or the rate of interventions between the two groups. The findings suggest that ?(1A)-adrenoceptor blockade was clinically superior for stone expulsion our study population. PMID:21917021

Tsuzaka, Yasuo; Matsushima, Hisashi; Kaneko, Tomoyuki; Yamaguchi, Tsuyoshi; Homma, Yukio

2011-09-14

233

Patterns of sexual behaviour of male patients before testing HIV-positive in a Cambodian hospital, Phnom Penh  

PubMed Central

Background Sexual behaviours among HIV-positive male patients in Cambodia have not been fully evaluated. Objectives The patterns of sexual behaviours and social factors were compared between married and single men. Methods A retrospective cross-sectional survey of 174 male HIV patients was undertaken during March 1999–June 2000 in Phnom Penh. Results Many participants (61%) reported that they were unaware that their sexual behaviours may have put them at risk of HIV infection. Sexual behaviours included having sex with a sex worker (90%), multiple sexual partners (41%), and both of these behaviours (37%). Two-thirds (69%) reported using a condom when having sex with a sex worker. Condom use with multiple sexual partners was low (24%). A history of condom use with a sex worker was less likely to be reported among married men than single men (P = 0.008). Always using condoms with a sex worker did not differ between married men and single men. Social factors that influenced visiting a sex worker included invitation by a friend (88%), alcohol consumption (74%), and having extra spending money (72%). Multivariate analysis suggests that alcohol consumption (P = 0.008) and having extra spending money (P = 0.02) were strongly associated with visiting a sex worker. Conclusions In Cambodia, HIV-infected men frequently reported a history of using sex workers. Having multiple sex partners or using a sex worker and multiple sexual partners were not rare. Interventions should target men in settings where alcohol is consumed and to encourage married men to use condoms.

Sok, Phan; Harwell, Joseph I.; Dansereau, Lynne; McGarvey, Stephen; Lurie, Mark; Mayer, Kenneth H.

2010-01-01

234

Dose-response analysis of testosterone replacement therapy in patients with female to male gender identity disorder.  

PubMed

Gender identity disorder (GID) is a conflict between a person's actual physical gender and the one they identify him or herself with. Testosterone is the key agent in the medical treatment of female to male GID patients. We conducted a dose-response analysis of testosterone replacement therapy (TRT) in 138 patients to determine the onset of the therapeutic effects. The TRT consisted of intramuscular injection of testosterone enanthate and patients were divided into three groups; 250 mg every two weeks, 250 mg every three weeks and 125 mg every two weeks. The onset of deepening of voice, increase in facial hair and cessation of menses was evaluated in each group. At one month after the start of TRT, the onset of these physical changes was more prevalent in the group receiving the higher dose of testosterone, and there were dose-dependent effects observed between the three treatment groups. On the other hand, at six months after the start of TRT, most of the patients had achieved treatment responses and there were no dose-dependent effects with regard to the percentage of patients with therapeutic effects. No significant side effects were observed in any of the treatment groups. We demonstrated that the early onset of the treatment effects of TRT is dose-dependent, but within six months of starting TRT, all three doses were highly effective. Current study provides useful information to determine the initial dose of TRT and to suggest possible changes that should be made in the continuous dosage for long term TRT. PMID:23117148

Nakamura, Aya; Watanabe, Masami; Sugimoto, Morito; Sako, Tomoko; Mahmood, Sabina; Kaku, Haruki; Nasu, Yasutomo; Ishii, Kazushi; Nagai, Atsushi; Kumon, Hiromi

2012-10-27

235

Predictors' Factors of Nutritional Status of Male Chronic Obstructive Pulmonary Disease Patients  

PubMed Central

Chronic obstructive pulmonary disease (COPD) is a systemic disease that leads to weight loss and muscle dysfunction resulting in an increase in mortality. This study aimed to determine the prevalence rate of malnutrition and nutritional status and also factors associated with nutritional status. A total of 149 subjects were involved in the cross-sectional study. The study was conducted at two medical centers in Kuala Lumpur, Malaysia. The results of the study showed that malnutrition was more prevalent (52.4%) in the subjects with severe stages of COPD as compared to mild and moderate COPD stages (26.2%) (P < 0.05). Fat-free mass depletion as assessed using fat-free mass index (FFMI) affected 41.9% of the subjects. Plasma vitamin A, peak expiratory flow (PEF), and handgrip were the predictors for body mass index (BMI) (R2 = 0.190, P < 0.001). Plasma vitamin A and force expiratory volume in one second (FEV1) were the predictors of FFMI (R2 = 0.082, P = 0.007). BMI was the predictor of respiratory factors, that is, FEV1% predicted (R2 = 0.052, P = 0.011). It can be concluded that there is a need to identify malnourished COPD patients for an appropriate nutrition intervention.

Pirabbasi, Elham; Najafiyan, Mahin; Cheraghi, Maria; Shahar, Suzana; Abdul Manaf, Zahara; Rajab, Norfadilah; Abdul Manap, Roslina

2012-01-01

236

Predictors' factors of nutritional status of male chronic obstructive pulmonary disease patients.  

PubMed

Chronic obstructive pulmonary disease (COPD) is a systemic disease that leads to weight loss and muscle dysfunction resulting in an increase in mortality. This study aimed to determine the prevalence rate of malnutrition and nutritional status and also factors associated with nutritional status. A total of 149 subjects were involved in the cross-sectional study. The study was conducted at two medical centers in Kuala Lumpur, Malaysia. The results of the study showed that malnutrition was more prevalent (52.4%) in the subjects with severe stages of COPD as compared to mild and moderate COPD stages (26.2%) (P < 0.05). Fat-free mass depletion as assessed using fat-free mass index (FFMI) affected 41.9% of the subjects. Plasma vitamin A, peak expiratory flow (PEF), and handgrip were the predictors for body mass index (BMI) (R(2) = 0.190, P < 0.001). Plasma vitamin A and force expiratory volume in one second (FEV(1)) were the predictors of FFMI (R(2) = 0.082, P = 0.007). BMI was the predictor of respiratory factors, that is, FEV(1)% predicted (R(2) = 0.052, P = 0.011). It can be concluded that there is a need to identify malnourished COPD patients for an appropriate nutrition intervention. PMID:23209935

Pirabbasi, Elham; Najafiyan, Mahin; Cheraghi, Maria; Shahar, Suzana; Abdul Manaf, Zahara; Rajab, Norfadilah; Abdul Manap, Roslina

2012-11-14

237

Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes  

Microsoft Academic Search

The aim of this study was to evaluate the effects of pioglitazone on clinical and metabolic parameters, body fat distribution, and serum adiponectin, a recently discovered antiatherosclerotic hormone, in Japanese patients with type 2 diabetes. Ten male patients aged 40 to 66 (57.7 [plusmn] 7.4) years, who were being treated with dietary therapy alone (n = 7) or with a

Hiroshi Hirose; Toshihide Kawai; Yukihiro Yamamoto; Matsuo Taniyama; Motowo Tomita; Koichi Matsubara; Yasunori Okazaki; Tatsuya Ishii; Yuko Oguma; Izumi Takei; Takao Saruta

2002-01-01

238

Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas  

PubMed Central

Background S-phase kinase-associated protein 2 (Skp2) is a member of mammalian F-box proteins. The purpose of this study is to clarify the prognostic significance of expression of Skp2 related to gender, estrogen receptor (ER) and progesterone receptor (PGR) in soft tissue sarcomas (STS). Skp2 has been demonstrated to display an oncogenic function since its overexpression has been observed in many human cancers. Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant therapy. The prognostic significance of Skp2 related to ER and PGR in STS has not been sufficiently investigated. Methods Tissue microarrays from 193 STS patients were constructed from duplicate cores of viable and representative neoplastic tumor areas. Immunohistochemistry was used to evaluate the expression of Skp2, ER and PGR. Results In univariate analyses, high tumor expression of Skp2 correlated (p?=?0.050) with reduced disease-specific survival (DSS). In subgroup analyses expression of PGR in males (p?=?0.010) and in patients older than 60?years (p?=?0.043) were negative prognostic factors for DSS. Expression of ER in females was a positive prognostic factor for DSS (p?=?0.041). In co-expression analyses in the whole cohort, low expression of Skp2 in combination with low expression of ER was positive for DSS (p?=?0.049). In females high expression of Skp2 in combination with low expression of ER was a negative prognosticator (p?=?0.021). In the multivariate analyses, age (p?=?0.012), malignancy grade (p?male and female patients with STS. In men, but not women, ER positive / PGR negative co-expression profile was an independent negative prognostic factor for DSS. In women, but not men, high expression of Skp2 was associated with reduced DSS.

2013-01-01

239

Alterations in Hormone Levels After Adjuvant Chemoradiation in Male Rectal Cancer Patients  

SciTech Connect

Purpose: To evaluate follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels after postoperative chemoradiation in men with rectal cancer. Methods and Materials: Forty-three men with rectal cancer had baseline and postchemoradiation FSH, LH, and testosterone measured. Adjuvant chemoradiation consisted of two 5-day cycles of bolus 5-fluorouracil (5-FU) every 4 weeks at a dose of 500 mg/m{sup 2}/d followed by concurrent chemoradiation followed by two additional 5-day cycles of 5-FU at a dose of 450 mg/m{sup 2}/d. Continuous-infusion 5-FU at 225 mg/m{sup 2}/d was given during radiation. Pelvic radiation consisted of a three- or four-field technique with a median dose of 54.0 Gy in 30 fractions. Results: Median follow-up was 6.1 years. Mean baseline FSH levels increased from 5.3 to a peak of 23.9 IU/L (p < 0.001) 13-24 months after chemoradiation. Mean baseline LH levels increased from 4.3 to a peak of 8.5 IU/L (p < 0.001) within 6 months after chemoradiation. Mean testosterone levels decreased from 15.4 nmol/L at baseline to 8.0 nmol/L more than 4 years after chemoradiation. Mean testosterone to mean LH ratio decreased from 4.4 at baseline to 1.1 after 48 months posttreatment, suggesting a continued decrease in Leydig cell function with time. Testicular dose was measured in 5 patients. Median dose was 4 Gy (range, 1.5-8.9 Gy). Conclusions: Chemoradiation in men with rectal cancer causes persistent increases in FSH and LH levels and decreases in testosterone levels.

Yoon, Frederick H. [Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario (Canada); Perera, Francisco [Department of Oncology, Division of Radiation Oncology, London Regional Cancer Program, University of Western Ontario, London, Ontario (Canada)], E-mail: francisco.perera@lhsc.on.ca; Fisher, Barbara [Department of Oncology, Division of Radiation Oncology, London Regional Cancer Program, University of Western Ontario, London, Ontario (Canada); Stitt, Larry [Department of Clinical Epidemiology, University of Western Ontario, London, Ontario (Canada)

2009-07-15

240

Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation  

PubMed Central

Background Serum preptin levels among subjects with different bone mineral densities (BMD) were measured and investigated to determine the correlation between BMD and bone-metabolic markers. Methods Approximately 52 elderly male patients with osteoporosis, 50 elderly men with osteopaenia, and 31 age-matched normal bone mass controls participated in the study. The serum preptin levels and bone metabolic markers were measured by enzyme-linked immunosorbent assay. The relationships between preptin levels, BMD, and metabolic parameters were also assessed. Results The serum preptin level was the lowest in the osteoporosis group and positively correlated with BMD. All the bone formation markers in the osteoporosis and osteopaenia groups were significantly reduced compared with those in the normal group. Serum preptin level was positively correlated with all the bone formation markers, whereas no correlation was observed with the bone resorption marker TRACP-5b. Conclusions Serum preptin levels are decreased in osteoporosis and osteopaenia patients and positively correlated with BMD. Therefore, preptin is involved in the pathogenesis of osteoporosis, probably through bone formation rather than bone resorption.

2013-01-01

241

Relative contribution of resting haemodynamic profile and lung function to exercise tolerance in male patients with chronic heart failure  

PubMed Central

OBJECTIVE—To clarify the relative contribution of resting haemodynamic profile and pulmonary function to exercise capacity in patients with heart failure.?SETTING—Cardiology department and cardiac rehabilitation unit in a tertiary centre.?DESIGN—161 male patients (mean (SD) age 59 (9) years) with heart failure (New York Heart Association class II-IV, left ventricular ejection fraction 23 (7)%) underwent spirometry, alveolar capillary diffusing capacity (DLCO), and mouth inspiratory and expiratory pressures (MIP, MEP, respectively, in 100 patients). Right heart catheterisation and a symptom limited cardiopulmonary exercise test were performed in 137 patients within 3-4 days.?RESULTS—Mean peak exercise oxygen consumption (V?O2) was 13 (3.9) ml/kg/min. Among resting haemodynamic variables only cardiac index showed a significant correlation with peak V?O2. There were no differences in haemodynamic variables between patients with peak V?O2 ? or > 14 ml/kg/min. There was a moderate correlation (p < 0.05) between several pulmonary function variables and peak V?O2. Forced vital capacity (3.5 (0.9) v 3.2 (0.8) l, p < 0.05) and DLCO (21.6 (6.9) v 17.7 (5.5) ml/mm Hg/min, p < 0.05) were higher in patients with peak V?O2 > 14 ml/kg/min than in those with peak V?O2 ? 14 ml/kg/min. Using a stepwise regression analysis, the respiratory and haemodynamic variables which correlated significantly with peak V?O2 were DLCO, MEP, and cardiac index, with an overall R value of 0.63.?CONCLUSIONS—The data confirm previous studies showing a poor correlation between resting indices of cardiac function and exercise capacity in heart failure. However, several pulmonary function variables were related to peak exercise V?O2. In particular, lung diffusing capacity and respiratory muscle function seem to affect exercise tolerance during heart failure.???Keywords: heart failure; exercise; pulmonary function; alveolar-capillary diffusing capacity

Faggiano, P; D'Aloia, A; Gualeni, A; Giordano, A

2001-01-01

242

Drinking in the injury event: a comparison of Mexican-American male ER patients in the United States and in Mexico.  

PubMed

Probability samples of 66 Mexican-American injured male emergency room (ER) patients in Santa Clara County, CA, and 457 injured male ER patients in Pachuca, Mexico are compared on a number of drinking-in-the-event variables. While those in Pachuca were more likely to be positive on the breathalyzer than those in Santa Clara, they were less likely to attribute a causal association of their drinking with the event. Site (Santa Clara) was found to be a significant (positive) predictor of drinking prior to injury. PMID:11848157

Cherpitel, Cheryl J; Borges, Guilherme

2002-01-01

243

Reasons for recall following conditional discharge: explanations given by male patients suffering from dual diagnosis in a London Forensic Unit.  

PubMed

ACCESSIBLE SUMMARY: Patients who have been discharged from forensic services often have conditions they have to abide by as part of their discharge, and failure to do so leads to recall. We interviewed six men who had been conditionally discharged from forensic services and then been recalled into hospital to find out what they thought went wrong. The reasons they gave for why things went wrong included feeling that the system was unfair and made them feel like criminals even though they did not feel they had put anyone at risk. Some of them were not fully aware of the conditions they needed to adhere to, and some of them had breached the conditions but did not take responsibility for what had happened. In addition, supervision was felt to be very controlling and disruptive rather than supportive when patients were often lonely, bored and needing support. Most participants reported that they experienced poor standards of aftercare in hostels they were required to reside in. In the future, care of patients after conditional discharge should include better communication between patients and their supervisory team, recognition of the need for more support and improvements in the standards of care in hostels, as well as a collaborative approach to risk assessment that might reduce the frequency of relapse and readmission. ABSTRACT: This study explores how male patients suffering from dual diagnosis in a forensic unit perceive being recalled and readmitted following conditional discharge and their views about how services might be improved. A qualitative approach was used drawing on grounded theory techniques. Audiotaped semistructured interviews collected data from a purposefully selected sample of six participants who had been recalled and met the inclusion criteria of the study. Data were analysed using the constant comparative method. Most participants perceived the recall system as unfair, inappropriately criminalized their behaviour and was based on an assessment of risk that they did not understand or accept. Participants were not fully aware of the conditions of their discharge, and most did not accept responsibility for their role in being recalled and blamed the system. Care following discharge was rarely seen as positive, and poor standards in hostels were reported by most participants. Supervision was often seen as disruptive and controlling, and focused more on surveillance rather than support. Better communication might have helped them understand and adhere to the conditions of their discharge. Participants identified the importance of family and friends to their recovery, the importance of having their own accommodation, and the need to be more independent. PMID:23651216

Chiringa, J; Robinson, J E; Clancy, C

2013-05-01

244

Inappropriate tall stature and renal ectopy in a male patient with X-linked congenital adrenal hypoplasia due to a novel missense mutation in the DAX-1 gene.  

PubMed

Mutations in DAX-1 gene cause congenital adrenal hypoplasia (AHC). We present a male patient affected by X-linked adrenal hypoplasia congenita due to a novel DAX-1 missense mutation. The mutation V287G affects the C-terminal end of the DAX-1 protein which plays an important role in functioning of the receptor. In addition, our patient presented an inappropriate tall stature and renal ectopy, which have not been described in AHC so far. PMID:15800903

Franzese, Adriana; Brunetti-Pierri, Nicola; Spagnuolo, Maria Immacolata; Spadaro, Raffaella; Giugliano, Michela; Mukai, Tokuo; Valerio, Giuliana

2005-05-15

245

A comparison of quality of life, demographic and clinical characteristics of Brazilian men with fibromyalgia syndrome with male patients with depression  

Microsoft Academic Search

The primary aim of this study was to assess the quality of life (Qol) in men with fibromyalgia (FM) as compared to the Qol\\u000a of depressive patients, using the SF-36 questionnaire. The secondary objectives were as follows: to describe demographic and\\u000a clinical characteristics of male patients with FM; to evaluate basal levels of dehydroepiandrosterone sulfate (DHEAS) and\\u000a total testosterone in

Gilberto Toshimitsu Yoshikawa; Roberto Ezequiel Heymann; Milton Helfenstein Jr; Daniel Feldman Pollak

2010-01-01

246

Methadone-Mediated Autonomic Functioning of Male Patients with Heroin Dependence: The Influence of Borderline Personality Pattern  

PubMed Central

Background We hypothesize that the population with borderline personality shows different autonomic response to methadone compared to individuals with other personalities. This study applies heart rate variability (HRV) measurements and the Tridimensional Personality Questionnaire (TPQ) to examine this hypothesis. Methodology/Principal Findings Forty-four male patients with heroin dependence were recruited from a methadone maintenance treatment program. Eight personality patterns were classified according to the TPQ norm used in Taiwan. The borderline pattern (BP, composed of high novelty seeking, high harm avoidance and low reward dependence) and the other personality patterns (OP) were separated into two groups. We compared the HRV profiles between the BP and OP groups. Correlation and regression analysis were performed to clarify relationship between HRV differences and the borderline index (BI, a new concept defined by us, which is calculated as novelty seeking + harm avoidance – reward dependence). The HRV targets investigated included low frequency (LF) power, high frequency (HF) power, total power (TP), normalized LF (LF%), and LF/HF. No baseline HRV parameters showed any inter-group difference. The BP group had a significantly lower ?HF and a higher ?LF/HF than the OP group. The personality dimension, reward dependence, showed a negative correlation with ?LF/HF and ?LF%. BI was negatively correlated with ?HF and positively correlated with ?LF/HF and ?LF%. Conclusions/Significance Borderline personality individuals show increased sympathetic activity and decreased parasympathetic activity compared to other personalities after taking methadone. The results support the hypothesis that there is an interaction between borderline personality and autonomic modulation.

Huang, Wei-Lieh; Lin, Yu-Hsuan; Kuo, Terry B. J.; Chang, Li-Ren; Chen, Ying-Zai; Yang, Cheryl C. H.

2012-01-01

247

Successful extracorporeal mature oocyte harvesting after laparoscopic oophorectomy following controlled ovarian hyperstimulation for the purpose of fertility preservation in a patient with borderline ovarian tumor  

Microsoft Academic Search

Purpose  To report the successful extracorporeal recovery of mature oocytes after laparoscopic oophorectomy following ovarian hyperstimulation\\u000a for the purpose of fertility preservation in a patient with recurrent serous borderline ovarian tumor.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  A 25-year-old nulligravida woman presented with recurrence of a borderline serous adenocarcinoma in the right ovary after\\u000a been treated conservatively with left oophorectomy for the same.\\u000a \\u000a \\u000a \\u000a \\u000a Result(s)  The patient underwent ovarian

Silvina Bocca; Daynelle Dedmond; Estella Jones; Laurel Stadtmauer; Sergio Oehninger

248

Increased blood pressure levels relative to subjective feelings of intensity of exercise determined with the Borg scale in male patients with hypertension.  

PubMed

We examined the hemodynamic responses to exercise and symptoms in 37 male patients with untreated essential hypertension, and compared the findings with those in 32 age-matched healthy male volunteers by performing a graded symptom-limited exercise test using a bicycle ergometer. The subjective feeling of intensity of exercise was determined using the Borg scale. In the relationship between Borg scores and blood pressure (BP), patients with hypertension showed higher systolic BP and diastolic BP relative to the Borg scores than the controls. Consequently, patients with hypertension showed significantly higher systolic BP with Borg scores < or = 3 (subjective symptoms < or = moderately hard) than the controls (177.8 +/- 27.0 vs. 143.7 +/- 17.9 mmHg, p < 0.0001). Similarly, significantly higher diastolic BP with Borg scores < or = 3 was observed in patients with hypertension than in the controls (101.6 +/- 12.0 vs. 82.6 +/- 11.6 mmHg, p < 0.0001). The pulse pressure with Borg scores < or = 3 was also significantly higher in patients with hypertension than in the controls (76.2 +/- 20.6 vs. 61.0 +/- 13.6 mmHg, p < 0.0001). Hypertensive patients showed a decrease in the high-frequency power of heart rate variability at initial low-load exercise. In conclusion, the present study revealed that there was a greater BP response relative to the Borg score in patients with hypertension than in the controls. Autonomic nerve activity may contribute to some extent to these different relations. A determination of the relationship between the subjective feeling of intensity of the exercise and BP levels caused by a given intensity of load is essential before exercise training in patients, at least in males, with hypertension to avoid increasing the risk of cardiovascular events in association with excessive exercise training. PMID:18425699

Mayumi, Eriko; Nishitani, Aya; Yuki, Yoko; Nakatsu, Takaaki; Toyonaga, Shinji; Mashima, Keiichi; Ogawa, Hiroko; Hirohata, Satoshi; Usui, Shinichi; Shinohata, Ryoko; Sakaguchi, Kousaku; Kusachi, Shozo

2008-04-01

249

Exome sequencing in a family with an X-linked lethal malformation syndrome: clinical consequences of hemizygous truncating OFD1 mutations in male patients.  

PubMed

Oral-facial-digital syndrome type 1 (OFD1; OMIM #311200) is an X-linked dominant disorder, caused by heterozygous mutations in the OFD1 gene and characterized by facial anomalies, abnormalities in oral tissues, digits, brain, and kidney; and male lethality in the first or second trimester pregnancy. We encountered a family with three affected male neonates having an 'unclassified' X-linked lethal congenital malformation syndrome. Exome sequencing of entire transcripts of the whole X chromosome has identified a novel splicing mutation (c.2388+1G > C) in intron 17 of OFD1, resulting in a premature stop codon at amino acid position 796. The affected males manifested severe multisystem complications in addition to the cardinal features of OFD1 and the carrier female showed only subtle features of OFD1. The present patients and the previously reported male patients from four families (clinical OFD1; Simpson-Golabi-Behmel syndrome, type 2 with an OFD1 mutation; Joubert syndrome-10 with OFD1 mutations) would belong to a single syndrome spectrum caused by truncating OFD1 mutations, presenting with craniofacial features (macrocephaly, depressed or broad nasal bridge, and lip abnormalities), postaxial polydactyly, respiratory insufficiency with recurrent respiratory tract infections in survivors, severe mental or developmental retardation, and brain malformations (hypoplasia or agenesis of corpus callosum and/or cerebellar vermis and posterior fossa abnormalities). PMID:22548404

Tsurusaki, Y; Kosho, T; Hatasaki, K; Narumi, Y; Wakui, K; Fukushima, Y; Doi, H; Saitsu, H; Miyake, N; Matsumoto, N

2012-05-01

250

The cost-effectiveness of syndromic management for male sexually transmitted disease patients with urethral discharge symptoms and genital ulcer disease in Taiwan  

Microsoft Academic Search

Objective:To assess the cost-effectiveness of syndromic management for the treatment of sexually transmitted diseases (STD) in comparison with the strategies currently used in STD clinics in Taiwan.Methods:Between July 2004 and June 2005, all male patients with genitourinary symptoms attending two hospitals were included in this study. Current clinical procedures (presumptive treatment and laboratory tests), aetiological diagnosis and syndromic management were

C-H Tsai; T-C Lee; H-L Chang; L-H Tang; C-C Chiang; K-T Chen

2008-01-01

251

Analyses of donor-derived keratinocytes in hairy and nonhairy skin biopsies of female patients following allogeneic male bone marrow transplantation.  

PubMed

Skin samples taken from 6 female patients receiving allogeneic bone marrow transplants (BMT) from male siblings (n=5) or from unrelated human leukocyte antigen (HLA)-matched male donor (n=1) due to hematological malignancies were studied for the presence of donor cells. One nontransplanted male and 1 female control that received female BM were used as further controls of the technique. Skin biopsies were taken from the scalp and the back from each patient 12-16 years after the successful BMT. We have found donor chimerism in all of the 6 patients in both of their biopsies. Using single and double immunostainings in combination with Y chromosome hybridization, we observed that there are cytokeratin-expressing donor-derived cells in the epidermis of all the 6 patients, the numbers being slightly higher in the scalp (0.37%-1.78%) than in the back (0.32%-1.08%) biopsies. The indication for BMT, and the age of the patient did not seem to have any effect on the numbers found. A few of the double-labeled cells also stained for Ki67, a marker of cellular proliferation, suggesting that the engrafted cells were able to further divide in the epidermis. In 2 patients we observed patches of donor keratinocytes within the epidermis, suggesting a clonal origin. We conclude that in agreement with some and in contrast to other published studies, BM-derived circulating cells are able to engraft in the human skin and to further proliferate there and thus contribute to tissue renewal. These data raise the possibility to use BM cells in regenerative medicine to help in extended injuries, large surface burns, or lack of skin due to other reasons. PMID:21288071

Nemeth, Krisztian; Key, Sharon; Bottlik, Gyula; Masszi, Tamas; Mezey, Eva; Karpati, Sarolta

2011-03-17

252

Concurrent Koro and Cotard Syndromes in a Spanish Male Patient with a Psychotic Depression and Cerebrovascular Disease  

Microsoft Academic Search

Koro and Cotard syndromes are uncommon conditions described in a variety of psychiatric and medical disorders. The authors report the third case of a simultaneous presentation of both syndromes, in a 62-year-old inpatient Spanish male with major depressive disorder with psychotic features, parkinsonism and cognitive impairment. A discussion of the literature and the possible relationship between both syndromes and other

P. Alvarez; V. M. Puente; M. J. Blasco; P. Salgado; A. Merino; A. Bulbena

2012-01-01

253

The use of pornographic materials by adolescent male cancer patients when banking sperm in the UK: legal and ethical dilemmas.  

PubMed

Increased awareness of the importance of fertility concerns to teenage cancer survivors is leading to growing numbers of male teenagers being offered sperm banking at the time of diagnosis. This is now extending to males diagnosed with other conditions where gonadotoxic agents are used in treatment. The storage of sperm in these circumstances is a challenging aspect of health care, given the complex issues and timescale involved. UK law has been enacted to protect legal minors from the potentially harmful effects of exposure to pornographic materials, yet there is reason to suppose that their use in this context could have therapeutic benefit in aiding successful masturbation. This paper uses material gained through consultation with the eleven largest UK sperm banks and 94 male teenage cancer survivors, to discuss the associated legal and ethical dilemmas, including those around the role of parents/carers. Findings suggest that there is variable practice in sperm banks, that almost a quarter of teenage males wanted access to soft porn when banking sperm, and half wanted to bring in their own materials. It concludes that there is an urgent need for any legal barriers to the therapeutic use of pornographic materials to be understood and examined. PMID:17786648

Crawshaw, Marilyn A; Glaser, Adam W; Pacey, Allan A

2007-09-01

254

Interdisciplinary treatment of Class III malocclusion: a case report  

Microsoft Academic Search

The case report describes the multidisciplinary treatment of a 25-year-old male patient with a Class III malocclusion. Anterior and bilateral posterior crossbites were present. To correct the posterior crossbite a surgically assisted rapid maxillary expansion was performed. The significant three dimensional skeletal discrepancy was solved in a second phase with a surgical advancement of the maxilla. Functional and aesthetic occlusion

Daniele Parrello; Laura Bolamperti; Alberto Caprioglio

2011-01-01

255

Concurrent Koro and Cotard syndromes in a Spanish male patient with a psychotic depression and cerebrovascular disease.  

PubMed

Koro and Cotard syndromes are uncommon conditions described in a variety of psychiatric and medical disorders. The authors report the third case of a simultaneous presentation of both syndromes, in a 62-year-old inpatient Spanish male with major depressive disorder with psychotic features, parkinsonism and cognitive impairment. A discussion of the literature and the possible relationship between both syndromes and other neuropsychiatric disorders are presented. PMID:22310658

Alvarez, P; Puente, V M; Blasco, M J; Salgado, P; Merino, A; Bulbena, A

2012-02-04

256

Tolerability and safety of alosetron during long-term administration in female and male irritable bowel syndrome patients  

Microsoft Academic Search

OBJECTIVES:Alosetron (Lotronex) is a new therapeutic agent for irritable bowel syndrome (IBS) in women with diarrhea-predominant IBS. This multicenter randomized, double-blind, placebo-controlled study assessed the safety and tolerability of alosetron during long-term (?12 months) treatment.METHODS:A total of 859 subjects (637 female and 222 male) with IBS were enrolled from 130 sites in the United States and were randomized 3:1 to

Steven G. Wolfe; William Y. Chey; Mary Kay Washington; Jacqueline Harding; Amy T. Heath; David J. McSorley; George E. Dukes; Christine M. Hunt

2001-01-01

257

[Genotypic sex and phenotypic sex: clinical, biochemical and molecular aspects in a patient with male hypogonadism and 46XX-45XO karyotype].  

PubMed

We report here the case of a patient with primary male ipogonadism, with small testes and deficient virilization of the external genitalia, but with 46XX, 45X0 karyotype. Hormonal determinations showed high LH and FSH and low testosterone levels. Ultrasonography confirmed the presence of small testes within the scrotum. Cytogenetic analysis demonstrated a female karyotype, with 90% 46XX, 10% 45X0 mosaicism. Using DNA probes for genes located on the Y chromosome, the presence of the "Sex-Determining Region" of the Y chromosome (SRY) was evidenced in the genomic DNA of this patient. By Fluorescence in Situ Hybridization (FISH), SRY locus was localized in the p terminal region of an X chromosome. SRY is the primary inducer of testis development; it acts as a transcription factor leading to a sequence of gene activations critical in the process of testicular differentiation and morphogenesis. A condition characterized by testicular development in subjects who lack a normal Y chromosome has been described; most of these patients are carriers of the short arm of the Y chromosome transferred to one of the two X chromosome, suggesting a form of X-Y paternal interchange. In our patient, the development of male gonade in the absence of an Y chromosome was explained by the demonstration of the SRY gene in an X chromosome. PMID:11822095

Torre, R; Savino, A; Venturi, P; Taverna, R; Triacca, R; Coli, A; Bernasconi, D; Del Monte, P; Marugo, M

2001-12-01

258

A Male Patient with Humoral Hypercalcemia of Malignancy (HHM) with Leukocytosis Caused by Cutaneous Squamous Cell Carcinoma Resulting from Recessive Dystrophic Epidermolysis Bullosa  

PubMed Central

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin disorder. Although the patients are at risk for cutaneous squamous cell carcinoma (SCC), no case of cutaneous SCC derived from RDEB with humoral hypercalcemia of malignancy (HHM) has been reported. We present the first case report of a male patient with HHM with leukocytosis caused by cutaneous SCC resulting from RDEB. A 20-yr-old Japanese male patient with RDEB; the diagnosis was confirmed by electron microscopic examination, suffered an intractable skin ulcer and hypercalcemia and leukocytosis. PTH-rP, SCC antigen and Granulocyte colony-stimulating factor (G-CSF) levels were elevated. The histological diagnosis of the skin lesion was made well-differentiated SCC. Immunohistochemical staining showed the expression of PTH-rP in atypical tumor cells. For the control of hypercalcemia before an amputation, we used zoledronate safely and could control the serum Ca concentration in the normal range. After the amputation of his right leg including SCC, leukocytosis improved immediately and PTH-rP in blood decreased to the normal range. One month after the amputation, local recurrence of cutaneous SCC and multiple lung metastases were observed. PTH-rP increased gradually associated with hypercalcemia. Although the patient reached an unfortunate turning point about 4 mo after the amputation, we propose that zoledronate is an effective and safe treatment for HHM with cardiorenal complications.

Miura, Kohji; Umegaki, Noriko; Kitaoka, Taichi; Kubota, Takuo; Namba, Noriyuki; Etani, Yuri; Hirai, Haruhiko; Kogaki, Shigetoyo; Nakajima, Shigeo; Takahashi, Yuji; Tamai, Katsuto; Katayama, Ichiro; Ozono, Keiichi

2011-01-01

259

High rates of sexually transmitted diseases among male transvestites in Jakarta, Indonesia.  

PubMed

Many male transvestites (waria) in Jakarta, Indonesia engage in unprotected receptive anal and oral intercourse with homosexual and bisexual men for pay. Although this behaviour clearly puts them at risk of sexually transmitted diseases (STDs), including HIV infection, little is known about the prevalence of STD among them. To learn the STD prevalence and its risk factors, we conducted an STD prevalence survey among waria in North Jakarta, Indonesia. From August to December 1999 we offered screening for rectal and pharyngeal infections with Neisseria gonorrhoeae (Ng), Chlamydia trachomatis (Ct) by DNA probe (GenProbe PACE 2) and for Treponema pallidum (Tp) by non-treponemal and treponemal serological tests. Of 296 participants (median age 28 years), 93% reported having been paid for sex. A total of 96% reported having had oral sex (median five times/week) and/or anal sex (median three times/week) in the last week. Ng was found in the rectum of 12.8% and the pharynx of 4.2%; Ct was found in 3.8% and 2.4%, respectively. A total of 43.6% had reactive non-treponemal and treponemal tests. Of the 129 with positive treponemal tests, 42.6% had non-treponemal test titres greater than 1:8. In the logistic regression model, waria who were younger (< or =25 years old) had a significantly 3.5 times risk of Ng and/or Ct infections than older waria (>25 years old). Because only 12% of waria stated that they consistently used condoms during any sex act, it is important to warn them that STD/HIV transmission can occur with either anal or oral sex and that the risk of either anal or oral transmission can be reduced by condom use. In addition, high rates of asymptomatic syphilis and rectal gonorrhoea warrant a periodic screening and treatment for these infections in this population. Because waria have the highest rates of HIV and their clients consist of homosexual and bisexual men, successful prevention efforts in waria could help curb the spread of the epidemic. PMID:14511497

Joesoef, M R; Gultom, M; Irana, I D; Lewis, J S; Moran, J S; Muhaimin, T; Ryan, C A

2003-09-01

260

Age, Male Gender, and Atrial Fibrillation Predict Lower Extremity Amputation or Revascularization in Patients with Peripheral Artery Diseases: A Population-Based Investigation  

PubMed Central

By using the National Health Insurance (NHI) claim data of Taiwan, we sought to determine the predictors for nontraumatic lower extremity amputation (LEA) or peripheral revascularization procedures (PRP) in patients with peripheral artery disease (PAD). From the NHI claim data, we identified 12,206 patients with newly diagnosed PAD between 1998 and 2008, and followed them up to 2008. We explored the age, gender, and whether the patients had concomitant comorbid conditions, such as diabetes mellitus (DM), hypertension (HTN), atrial fibrillation (AF), stroke, hospitalization for coronary artery disease (CAD), myocardial infarction (MI), or heart failure (HF), and whether they were taking cilostazol at the time of recruitment. We searched for clinical parameters that might be important determinants for LEA or PRP in the study population. Of the 12,206 patients, 150 (1.2%) were found to undergo either LEA or PRP or both (LEA 81, PRP 53, both PRP and LEA 16). Old age, male gender, and history of hospitalization for CAD or MI and AF were found to be risk predictors for both procedures. Patients with DM were at lower risk for PRP (odds ratio 0.418, p?=?0.001). Patients who were taking cilostazol had higher risk for LEA or PRP. HTN was not a risk predictor for LEA or PRP. From this nationwide study, we found that among PAD patients in Taiwan, age, male gender, AF, and hospitalization for CAD or MI are risk predictors for future LEA or PRP. DM is a negative predictor for PRP while both DM and HTN are not risk predictors for LEA.

Chen, Jien-Jiun; Lin, Lian-Yu; Lee, Chang-Hsing; Liau, Chiau-Suong

2012-01-01

261

Screening of Male Patients for Trichomonas vaginalis with Transcription-Mediated Amplification in a Community with a High Prevalence of Sexually Transmitted Infection  

PubMed Central

Trichomonas vaginalis infection in males has been largely uncharacterized. Past reports indicated increased susceptibility to other sexually transmitted infection (STI) agents such as human immunodeficiency virus and Neisseria gonorrhoeae with concurrent T. vaginalis infection. This warrants a more thorough review of male T. vaginalis incidence. A retrospective 3-year investigation of transcription-mediated amplification (TMA)-based urethral swab and first-void urine screening for T. vaginalis within a regional health care system was performed to address T. vaginalis prevalence in males. Of 622 total samples tested, 6.6% were positive for T. vaginalis. Delineation of all specimens by ZIP code of patient residence revealed 11 predominant ZIP codes with respect to testing volume and detection rates. Within these 11 ZIP codes, representing 78.3% of total testing volume, urine was the preferred specimen source compared to urethral swabs. Seven of these 11 ZIP codes contained majority African American populations. The aggregate T. vaginalis detection rate trended higher than that of the remaining four ZIP codes, which were comprised primarily of Caucasian populations (8.9% versus 5.0%, respectively; P = 0.15). The average age of a T. vaginalis-infected male (39.9 years) was significantly greater than those for Chlamydia trachomatis or N. gonorrhoeae (27.6 and 25.9 years, respectively; P < 0.001). Given the significant rate of T. vaginalis detection, with age distribution analogous to that reported in females, TMA-based detection of T. vaginalis can be a routine constituent within a comprehensive STI screening panel for males in high-prevalence STI communities.

Munson, Kimber L.; Napierala, Maureen; Schell, Ronald F.; Kramme, Timothy; Miller, Cheryl; Hryciuk, Jeanne E.

2013-01-01

262

Male circumcision.  

PubMed

Male circumcision consists of the surgical removal of some, or all, of the foreskin (or prepuce) from the penis. It is one of the most common procedures in the world. In the United States, the procedure is commonly performed during the newborn period. In 2007, the American Academy of Pediatrics (AAP) convened a multidisciplinary workgroup of AAP members and other stakeholders to evaluate the evidence regarding male circumcision and update the AAP's 1999 recommendations in this area. The Task Force included AAP representatives from specialty areas as well as members of the AAP Board of Directors and liaisons representing the American Academy of Family Physicians, the American College of Obstetricians and Gynecologists, and the Centers for Disease Control and Prevention. The Task Force members identified selected topics relevant to male circumcision and conducted a critical review of peer-reviewed literature by using the American Heart Association's template for evidence evaluation. Evaluation of current evidence indicates that the health benefits of newborn male circumcision outweigh the risks; furthermore, the benefits of newborn male circumcision justify access to this procedure for families who choose it. Specific benefits from male circumcision were identified for the prevention of urinary tract infections, acquisition of HIV, transmission of some sexually transmitted infections, and penile cancer. Male circumcision does not appear to adversely affect penile sexual function/sensitivity or sexual satisfaction. It is imperative that those providing circumcision are adequately trained and that both sterile techniques and effective pain management are used. Significant acute complications are rare. In general, untrained providers who perform circumcisions have more complications than well-trained providers who perform the procedure, regardless of whether the former are physicians, nurses, or traditional religious providers. Parents are entitled to factually correct, nonbiased information about circumcision and should receive this information from clinicians before conception or early in pregnancy, which is when parents typically make circumcision decisions. Parents should determine what is in the best interest of their child. Physicians who counsel families about this decision should provide assistance by explaining the potential benefits and risks and ensuring that parents understand that circumcision is an elective procedure. The Task Force strongly recommends the creation, revision, and enhancement of educational materials to assist parents of male infants with the care of circumcised and uncircumcised penises. The Task Force also strongly recommends the development of educational materials for providers to enhance practitioners' competency in discussing circumcision's benefits and risks with parents. The Task Force made the following recommendations:Evaluation of current evidence indicates that the health benefits of newborn male circumcision outweigh the risks, and the benefits of newborn male circumcision justify access to this procedure for those families who choose it. Parents are entitled to factually correct, nonbiased information about circumcision that should be provided before conception and early in pregnancy, when parents are most likely to be weighing the option of circumcision of a male child. Physicians counseling families about elective male circumcision should assist parents by explaining, in a nonbiased manner, the potential benefits and risks and by ensuring that they understand the elective nature of the procedure. Parents should weigh the health benefits and risks in light of their own religious, cultural, and personal preferences, as the medical benefits alone may not outweigh these other considerations for individual families. Parents of newborn boys should be instructed in the care of the penis, regardless of whether the newborn has been circumcised or not. Elective circumcision should be performed only if the infant's condition is stable and healthy. Male circumcision should be performed by tra

2012-08-27

263

Brief Family Treatment Intervention to Promote Aftercare Among Male Substance Abusing Patients in Inpatient Detoxification: A Quasi-Experimental Pilot Study  

PubMed Central

We developed a brief family treatment (BFT) intervention for substance abusing patients in inpatient detoxification to promote aftercare treatment post-detox. BFT consisted of meeting with the patient and a family member (spouse or parent) with whom the patient lived to review and recommend potential aftercare plans for the patient. A phone conference was used when logistics prevented an in-person family meeting. Results indicated that male substance abusing patients who received BFT (N=14), as compared with a matched treatment as usual (TAU) comparison group (N=14) that did not, showed a trend toward being more likely to enter an aftercare program and to attend more days of aftercare in the 3 months after detoxification. The magnitude of these differences favoring BFT over TAU was midway between a medium and a large effect size. Days using alcohol or drugs in the 3 months after detox were lower for treatment-exposed BFT patients who had an in-person family meeting than TAU counterparts (trend, medium effect), and for patients who entered aftercare regardless of treatment condition (significant large effect).

O'Farrell, Timothy J.; Murphy, Marie; Alter, Jane; Fals-Stewart, William

2007-01-01

264

Decreased aerobic capacity 4 years after aortic valve replacement in male patients operated upon for chronic aortic regurgitation  

PubMed Central

Exercise testing is underutilized in patients with valve disease. We have previously found a low physical work capacity in patients with aortic regurgitation 6 months after aortic valve replacement (AVR). The aim of this study was to evaluate aerobic capacity in patients 4 years after AVR, to study how their peak oxygen uptake (peakVO2) had changed postoperatively over a longer period of time. Twenty-one patients (all men, 52 ± 13 years) who had previously undergone cardiopulmonary exercise testing (CPET) pre- and 6 months postoperatively underwent maximal exercise testing 49 ± 15 months postoperatively using an electrically braked bicycle ergometer. Breathing gases were analysed and the patients' physical fitness levels categorized according to Åstrand's and Wasserman's classifications. Mean peakVO2 was 22·8 ± 5·1 ml × kg?1 × min?1 at the 49-month follow-up, which was lower than at the 6-month follow-up (25·6 ± 5·8 ml × kg?1 × min?1, P = 0·001). All but one patient presented with a physical fitness level below average using Åstrand's classification, while 13 patients had a low physical capacity according to Wasserman's classification. A significant decrease in peakVO2 was observed from six to 49 months postoperatively, and the decrease was larger than expected from the increased age of the patients. CPET could be helpful in timing aortic valve surgery and for the evaluation of need of physical activity as part of a rehabilitation programme.

Hedman, Kristofer; Tamas, Eva; Nylander, Eva

2012-01-01

265

Screening for y chromosome microdeletion in a nonobstructive azoospermic male patient with allogeneic bone marrow transplantation from his sister.  

PubMed

Genomic DNA of a patient diagnosed with nonobstructive azoospermia and with the history of allogenic bone marrow transplantation from his sister due to chronic myeloid leukemia was isolated from peripheral blood in order to screen Y chromosome microdeletions. 13 short tagged sites belonging to AZF a, b, and c loci were detected with multiplex polymerase chain reaction technique. Bands were determined in ZFX/ZFY wells, whereas no bands were determined in wells of other STS regions. DNA isolation was done from buccal mucosa smear to obtain genomic DNA from patient's own cells and multiplex polymerase chain reaction technique was performed again. Bands were seen in all wells of 13 STS regions. Y chromosome microdeletion was not detected in the patient. In conclusion, genomic DNA isolation in patients undergoing BMT should be done from patients' own cells. PMID:21209805

Gurkan, Hakan; Kucukdurmaz, Faruk; Akman, Tolga; Ayd?n, Filiz; Kadioglu, Ates

2010-12-16

266

Screening for Y Chromosome Microdeletion in a Nonobstructive Azoospermic Male Patient with Allogeneic Bone Marrow Transplantation from His Sister  

PubMed Central

Genomic DNA of a patient diagnosed with nonobstructive azoospermia and with the history of allogenic bone marrow transplantation from his sister due to chronic myeloid leukemia was isolated from peripheral blood in order to screen Y chromosome microdeletions. 13 short tagged sites belonging to AZF a, b, and c loci were detected with multiplex polymerase chain reaction technique. Bands were determined in ZFX/ZFY wells, whereas no bands were determined in wells of other STS regions. DNA isolation was done from buccal mucosa smear to obtain genomic DNA from patient's own cells and multiplex polymerase chain reaction technique was performed again. Bands were seen in all wells of 13 STS regions. Y chromosome microdeletion was not detected in the patient. In conclusion, genomic DNA isolation in patients undergoing BMT should be done from patients' own cells.

Gurkan, Hakan; Kucukdurmaz, Faruk; Akman, Tolga; Ayd?n, Filiz; Kadioglu, Ates

2010-01-01

267

Case–control study of male cancer patients exposed to arsenic-contaminated drinking water and tobacco smoke with relation to non-exposed cancer patients  

Microsoft Academic Search

The investigated data indicated that inorganic arsenic in drinking water is associated with increased mortality from different types of cancers. In the present study, biological samples (blood and scalp hair) of male subjects having lung and bladder cancers and non-cancerous subjects belonging to arsenic (As)-exposed area of southern parts of Pakistan were analysed for As contents. The As levels in

Sham Kumar Wadhwa; Tasneem Gul Kazi; Nida Fatima Kolachi; Hassan Imran Afridi; Sumaira Khan; Akhtar Ali Chandio; Abdul Qadir Shah; Ghulam Abbas Kandhro; Syeda Nasreen

2011-01-01

268

Mumps virus encephalomyelitis in a 19-year old male patient with an undefined severe combined immunodeficiency post-haematopoietic bone marrow transplantation: a rare fatal complication.  

PubMed

We describe a rare case of fatal mumps encephalomyelitis occurring in 19-year old male following matched unrelated donor peripheral blood haematopoietic stem cell transplantation (HSCT). The indication for HSCT was for an undefined form of severe combined immunodeficiency (SCID). Molecular typing of the mumps viral RNA isolated from neural tissue indicated that the infection was acquired at the time of a mumps outbreak in England and Wales that occurred between 2004 and 2006. This case highlights the importance of considering mumps in the differential diagnosis of central nervous system infection in highly immunosuppressed patients. PMID:23485346

Eyre, Toby A; Pelosi, Emanuela; McQuaid, Stephen; Richardson, Deborah; Newman, Joan; Hill, Kate; Veys, Paul; Davies, Graham; Orchard, Kim H

2013-02-26

269

Impact of beta2-agonists, beta-blockers, and their combination on cardiac function in elderly male patients with chronic obstructive pulmonary disease  

PubMed Central

Purpose This study was undertaken to determine the association between cardiac function and therapy with beta2-adrenoceptor agonists (?2-agonists), ?-blockers, or ?-blocker–?-agonist combination therapy in elderly male patients with chronic obstructive pulmonary disease (COPD). Patients and methods This was a retrospective cohort study of 220 elderly male COPD patients (mean age 84.1 ± 6.9 years). The patients were divided into four groups on the basis of the use of ?-blockers and ?2-agonists. N-terminal fragment pro-B-type natriuretic peptide (NT pro-BNP), left ventricular ejection fraction (LVEF), and other relevant parameters were measured and recorded. At follow-up, the primary end point was all-cause mortality. Results Multiple linear regression analysis revealed no significant associations between NT pro-BNP and the use of ?2-agonists (? = 35.502, P = 0.905), ?-blockers (? = 3.533, P = 0.989), or combination therapy (? = 298.635, P = 0.325). LVEF was not significantly associated with the use of ?2-agonists (? = ?0.360, P = 0.475), ?-blockers (? = ?0.411, P = 0.284), or combination therapy (? = ?0.397, P = 0.435). Over the follow-up period, 52 patients died, but there was no significant difference in mortality among the four groups (P = 0.357). Kaplan–Meier analysis showed no significant difference among the study groups (log-rank test, P = 0.362). After further multivariate adjustment, use of ?2-agonists (hazard ratio [HR] 0.711, 95% confidence interval [CI] 0.287–1.759; P = 0.460), ?-blockers (HR 0.962, 95% CI 0.405–2.285; P = 0.930), or combination therapy (HR 0.638, 95% CI 0.241–1.689; P < 0.366) were likewise not correlated with mortality. Conclusion There was no association between the use of ?2-agonists, ?-blockers, or ?-blocker-?2-agonist combination therapy with cardiac function and all-cause mortality in elderly male COPD patients, which indicated that they may be used safely in this population.

Zeng, Long-Huan; Hu, Yi-Xin; Liu, Lin; Zhang, Meng; Cui, Hua

2013-01-01

270

Genomic Aberrations in an African American Colorectal Cancer Cohort Reveals a MSI-Specific Profile and Chromosome X Amplification in Male Patients  

PubMed Central

Objective DNA aberrations that cause colorectal cancer (CRC) occur in multiple steps that involve microsatellite instability (MSI) and chromosomal instability (CIN). Herein, we studied CRCs from AA patients for their CIN and MSI status. Experimental Design Array CGH was performed on 30 AA colon tumors. The MSI status was established. The CGH data from AA were compared to published lists of 41 TSG and oncogenes in Caucasians and 68 cancer genes, proposed via systematic sequencing for somatic mutations in colon and breast tumors. The patient-by-patient CGH profiles were organized into a maximum parsimony cladogram to give insights into the tumors' aberrations lineage. Results The CGH analysis revealed that CIN was independent of age, gender, stage or location. However, both the number and nature of aberrations seem to depend on the MSI status. MSI-H tumors clustered together in the cladogram. The chromosomes with the highest rates of CGH aberrations were 3, 5, 7, 8, 20 and X. Chromosome X was primarily amplified in male patients. A comparison with Caucasians revealed an overall similar aberration profile with few exceptions for the following genes; THRB, RAF1, LPL, DCC, XIST, PCNT, STS and genes on the 20q12-q13 cytoband. Among the 68 CAN genes, all showed some level of alteration in our cohort. Conclusion Chromosome X amplification in male patients with CRC merits follow-up. The observed CIN may play a distinctive role in CRC in AAs. The clustering of MSI-H tumors in global CGH data analysis suggests that chromosomal aberrations are not random.

Brim, Hassan; Lee, Edward; Abu-Asab, Mones S.; Chaouchi, Mohamed; Razjouyan, Hadi; Namin, Hassanzadeh; Goel, Ajay; Schaffer, Alejandro A.; Ashktorab, Hassan

2012-01-01

271

Inappropriate social and sexual responses to a female student by male patients with dementia and organic brain disorder  

Microsoft Academic Search

Little attention has been directed toward inappropriate social and sexual approaches by patients with dementia diagnoses and\\u000a organic disorders of the brain. A female student who approached patients who had dementia and organic brain disorders was\\u000a frequently approached and touched in a sexual manner that was distressing to her and led her to believe that she was behaving\\u000a in a

Kathleen S. Mayers; Christy Solberg

1994-01-01

272

Male Infertility  

MedlinePLUS

... and abuse of other illegal drugs, emotional stress, obesity and age (fertility gradually decreases in men who are older than 35). Sometimes the cause of male infertility cannot be identified. In these cases, there may be an underlying genetic problem. Diagnosis & Tests Should men be checked for ...

273

Effects of meta-chlorophenylpiperazine on neuroendocrine and behavioral responses in male schizophrenic patients and normal volunteers.  

PubMed

Functional alterations in the central serotonergic system, including presynaptic and postsynaptic function, have been reported in schizophrenia. Recently, there have been conflicting reports that the increase in plasma cortisol or prolactin concentrations induced by meta-chlorophenylpiperazine (mCPP) was significantly blunted in schizophrenic patients compared with normal volunteers. Studies of the behavioral effects of mCPP, a serotonin (5-HT) receptor partial agonist with high affinity for 5-HT1C binding sites, have also yielded conflicting results in schizophrenic patients. The purpose of this study was to examine plasma levels of prolactin and cortisol, body temperature, and behavioral responses to mCPP and placebo in a single-blind study in 25 schizophrenic and 15 normal men. No differences either between schizophrenic patients and normal volunteers or between paranoid and undifferentiated/residual subtypes of schizophrenia were found in mCPP-induced prolactin, cortisol, or temperature responses. Schizophrenic patients and normal volunteers reported significant increases in feeling calm and feeling strange of comparable magnitude following mCPP. No significant differences between normal volunteers and schizophrenic patients were found in post-mCPP behavioral ratings, such as anxiety, irritability, depression, restlessness, or arousal. PMID:8944393

Maes, M; Meltzer, H Y

1996-10-16

274

Hybrid computational phantoms of the male and female newborn patient: NURBS-based whole-body models.  

PubMed

Anthropomorphic computational phantoms are computer models of the human body for use in the evaluation of dose distributions resulting from either internal or external radiation sources. Currently, two classes of computational phantoms have been developed and widely utilized for organ dose assessment: (1) stylized phantoms and (2) voxel phantoms which describe the human anatomy via mathematical surface equations or 3D voxel matrices, respectively. Although stylized phantoms based on mathematical equations can be very flexible in regard to making changes in organ position and geometrical shape, they are limited in their ability to fully capture the anatomic complexities of human internal anatomy. In turn, voxel phantoms have been developed through image-based segmentation and correspondingly provide much better anatomical realism in comparison to simpler stylized phantoms. However, they themselves are limited in defining organs presented in low contrast within either magnetic resonance or computed tomography images-the two major sources in voxel phantom construction. By definition, voxel phantoms are typically constructed via segmentation of transaxial images, and thus while fine anatomic features are seen in this viewing plane, slice-to-slice discontinuities become apparent in viewing the anatomy of voxel phantoms in the sagittal or coronal planes. This study introduces the concept of a hybrid computational newborn phantom that takes full advantage of the best features of both its stylized and voxel counterparts: flexibility in phantom alterations and anatomic realism. Non-uniform rational B-spline (NURBS) surfaces, a mathematical modeling tool traditionally applied to graphical animation studies, was adopted to replace the limited mathematical surface equations of stylized phantoms. A previously developed whole-body voxel phantom of the newborn female was utilized as a realistic anatomical framework for hybrid phantom construction. The construction of a hybrid phantom is performed in three steps: polygonization of the voxel phantom, organ modeling via NURBS surfaces and phantom voxelization. Two 3D graphic tools, 3D-DOCTOR and Rhinoceros, were utilized to polygonize the newborn voxel phantom and generate NURBS surfaces, while an in-house MATLAB code was used to voxelize the resulting NURBS model into a final computational phantom ready for use in Monte Carlo radiation transport calculations. A total of 126 anatomical organ and tissue models, including 38 skeletal sites and 31 cartilage sites, were described within the hybrid phantom using either NURBS or polygon surfaces. A male hybrid newborn phantom was constructed following the development of the female phantom through the replacement of female-specific organs with male-specific organs. The outer body contour and internal anatomy of the NURBS-based phantoms were adjusted to match anthropometric and reference newborn data reported by the International Commission on Radiological Protection in their Publication 89. The voxelization process was designed to accurately convert NURBS models to a voxel phantom with minimum volumetric change. A sensitivity study was additionally performed to better understand how the meshing tolerance and voxel resolution would affect volumetric changes between the hybrid-NURBS and hybrid-voxel phantoms. The male and female hybrid-NURBS phantoms were constructed in a manner so that all internal organs approached their ICRP reference masses to within 1%, with the exception of the skin (-6.5% relative error) and brain (-15.4% relative error). Both hybrid-voxel phantoms were constructed with an isotropic voxel resolution of 0.663 mm--equivalent to the ICRP 89 reference thickness of the newborn skin (dermis and epidermis). Hybrid-NURBS phantoms used to create their voxel counterpart retain the non-uniform scalability of stylized phantoms, while maintaining the anatomic realism of segmented voxel phantoms with respect to organ shape, depth and inter-organ positioning. PMID:17664546

Lee, Choonsik; Lodwick, Daniel; Hasenauer, Deanna; Williams, Jonathan L; Lee, Choonik; Bolch, Wesley E

2007-05-16

275

Hybrid computational phantoms of the male and female newborn patient: NURBS-based whole-body models  

NASA Astrophysics Data System (ADS)

Anthropomorphic computational phantoms are computer models of the human body for use in the evaluation of dose distributions resulting from either internal or external radiation sources. Currently, two classes of computational phantoms have been developed and widely utilized for organ dose assessment: (1) stylized phantoms and (2) voxel phantoms which describe the human anatomy via mathematical surface equations or 3D voxel matrices, respectively. Although stylized phantoms based on mathematical equations can be very flexible in regard to making changes in organ position and geometrical shape, they are limited in their ability to fully capture the anatomic complexities of human internal anatomy. In turn, voxel phantoms have been developed through image-based segmentation and correspondingly provide much better anatomical realism in comparison to simpler stylized phantoms. However, they themselves are limited in defining organs presented in low contrast within either magnetic resonance or computed tomography images—the two major sources in voxel phantom construction. By definition, voxel phantoms are typically constructed via segmentation of transaxial images, and thus while fine anatomic features are seen in this viewing plane, slice-to-slice discontinuities become apparent in viewing the anatomy of voxel phantoms in the sagittal or coronal planes. This study introduces the concept of a hybrid computational newborn phantom that takes full advantage of the best features of both its stylized and voxel counterparts: flexibility in phantom alterations and anatomic realism. Non-uniform rational B-spline (NURBS) surfaces, a mathematical modeling tool traditionally applied to graphical animation studies, was adopted to replace the limited mathematical surface equations of stylized phantoms. A previously developed whole-body voxel phantom of the newborn female was utilized as a realistic anatomical framework for hybrid phantom construction. The construction of a hybrid phantom is performed in three steps: polygonization of the voxel phantom, organ modeling via NURBS surfaces and phantom voxelization. Two 3D graphic tools, 3D-DOCTOR™ and Rhinoceros™, were utilized to polygonize the newborn voxel phantom and generate NURBS surfaces, while an in-house MATLAB™ code was used to voxelize the resulting NURBS model into a final computational phantom ready for use in Monte Carlo radiation transport calculations. A total of 126 anatomical organ and tissue models, including 38 skeletal sites and 31 cartilage sites, were described within the hybrid phantom using either NURBS or polygon surfaces. A male hybrid newborn phantom was constructed following the development of the female phantom through the replacement of female-specific organs with male-specific organs. The outer body contour and internal anatomy of the NURBS-based phantoms were adjusted to match anthropometric and reference newborn data reported by the International Commission on Radiological Protection in their Publication 89. The voxelization process was designed to accurately convert NURBS models to a voxel phantom with minimum volumetric change. A sensitivity study was additionally performed to better understand how the meshing tolerance and voxel resolution would affect volumetric changes between the hybrid-NURBS and hybrid-voxel phantoms. The male and female hybrid-NURBS phantoms were constructed in a manner so that all internal organs approached their ICRP reference masses to within 1%, with the exception of the skin (-6.5% relative error) and brain (-15.4% relative error). Both hybrid-voxel phantoms were constructed with an isotropic voxel resolution of 0.663 mm—equivalent to the ICRP 89 reference thickness of the newborn skin (dermis and epidermis). Hybrid-NURBS phantoms used to create their voxel counterpart retain the non-uniform scalability of stylized phantoms, while maintaining the anatomic realism of segmented voxel phantoms with respect to organ shape, depth and inter-organ positioning. This work was supported by the National Cancer Institute.

Lee, Choonsik; Lodwick, Daniel; Hasenauer, Deanna; Williams, Jonathan L.; Lee, Choonik; Bolch, Wesley E.

2007-07-01

276

Smoking and male gender rather than CagA protein are associated with increased risk for duodenal ulcer in Helicobacter pylori-infected patients in Taiwan.  

PubMed

The aim of this study was to examine the seroprevalence of antibody to CagA antigen, as well as other major H. pylori antigens by Western blot in H. pylori-infected subjects with endoscopically normal mucosa (N = 54) and duodenal ulcer (N = 51). The role of the host and environmental factors was also evaluated. There was no significant difference in the prevalence of antibodies against the major H. pylori antigens between the two groups. A high prevalence of antibody to CagA was detected in patients with normal mucosa (93%) and duodenal ulcer (86%). Multivariate analysis shows that male gender (odds ratio = 4.94, 95% CI = 1.39-17.77, P = 0.014) and smoking (odds ratio = 8.89, 95% CI = 2.17-36.48, P = 0.002) were associated with duodenal ulcer disease. This study suggests that smoking and male gender rather than CagA protein are associated with increased risk for duodenal ulcer in H. pylori-infected patients in Taiwan. PMID:10548360

Chen, T S; Chang, F Y; Lee, S D

1999-10-01

277

The effects of cranberry juice on serum glucose, apoB, apoA-I, Lp(a), and Paraoxonase-1 activity in type 2 diabetic male patients  

PubMed Central

Background: Type 2 diabetic patients are faced with a higher risk of dyslipidemia and cardiovascular disorders. This study was undertaken to assess the effect of consumption of 1 cup cranberry juice by type 2 diabetic patients on serum paraoxonase-1 (PON-1) activity, apoA-1, apoB, glucose, and Lp(a). Methods: In a double-blind randomized clinical trial, 58 type 2 diabetic male patients were randomly divided to receive 1 cup cranberry juice (CJ) or placebo drink daily for 12 weeks. Fasting blood were obtained at beginning and at the end of study (12th week). Serum glucose and PON-1 activity were measured by enzymatic and colorimetric methods, respectively. ApoB, apoA-I, and Lp(a) were determined immunoturbidimetrically. The data were analyzed by SPSS version 16. Results: There were significant decrease in serum glucose and apoB (P>0.05 and P>0.01, respectively) and significant increase in serum apoA-1 and PON-1 activity (P>0.05 and P<0.01, respectively) at the end of study in CJ group compared with control group. In CJ group at the end of study, there were significant decrease in serum glucose and apoB (P<0.01 and P<0.01, respectively) and significant increase in serum apo A-1 and PON-1 activity (P<0.01 and P<0.01, respectively) compared with initial values. In CJ group, there was no significant change in Lp(a) at the end of study compared with initial values and also compared with control group. Conclusion: 1 cup CJ for 12 weeks is effective in reducing serum glucose and apoB and increasing apoA-1 and PON-1 activity, so may have favorite effects on reducing CVD risk factors in type 2 diabetic male patients.

Shidfar, Farzad; Heydari, Iraj; Hajimiresmaiel, Seyed Javed; Hosseini, Sharieh; Shidfar, Shahrzad; Amiri, Fariba

2012-01-01

278

Evaluation of cadmium and zinc in biological samples of tobacco and alcohol user male mouth cancer patients  

Microsoft Academic Search

There is compelling evidence in support of positive associations between zinc (Zn) deficiency and high accumulation of cadmium (Cd) in biological samples of different cancerous patients. The incidence of mouth cancer has been increased among people who possess habit of drinking alcohol, tobacco smoking and chewing with gradients in Pakistan. In the present study, Cd and Zn contents of blood

Tasneem Gul Kazi; Sham Kumar Wadhwa; Hassan Imran Afridi; Naveed Kazi; Ghulam Abbas Kandhro; Jameel Ahmed Baig; Abdul Qadir Shah; Nida Fatima Kolachi; Sumaira Khan

2010-01-01

279

Bone Mineral Density and Vitamin D Status in Female and Male Patients with Osteoarthritis of the Knee or Hip  

Microsoft Academic Search

Objective: Osteoporosis (OP), osteoarthritis (OA) and vitamin D deficiency are age-related disorders. We investigated the association between bone mineral density (BMD), vitamin D and OA in patients undergoing total hip or knee replacements. Method: In total, 82 women and 35 men with mean ages of 70 and 68 years, respectively, were recruited for the study. The BMD of the lumbar

N. Breijawi; A. Eckardt; M. B. Pitton; A. J. Hoelzl; M. Giesa; D. von Stechow; F. Haid; P. Drees

2009-01-01

280

Male Osteoporosis  

PubMed Central

Synopsis Osteoporosis is now recognized as a major threat to health in aging men. Morbidity and mortality, particularly following hip fracture, are substantial. Whereas trabecular bone loss starts in early adulthood, loss of cortical bone only appears to occur from mid-life onwards. Declining bioavailable estradiol levels play an integral role in male age-associated bone loss. Both pharmacologic and supportive care interventions are important for optimal care in men at increased fracture risk.

Drake, Matthew T.; Khosla, Sundeep

2013-01-01

281

Hybrid computational phantoms of the 15-year male and female adolescent: applications to CT organ dosimetry for patients of variable morphometry.  

PubMed

Currently, two classes of the computational phantoms have been developed for dosimetry calculation: (1) stylized (or mathematical) and (2) voxel (or tomographic) phantoms describing human anatomy through mathematical surface equations and three-dimensional labeled voxel matrices, respectively. Mathematical surface equations in stylized phantoms provide flexibility in phantom design and alteration, but the resulting anatomical description is, in many cases, not very realistic. Voxel phantoms display far better anatomical realism, but they are limited in terms of their ability to alter organ shape, position, and depth, as well as body posture. A new class of computational phantoms--called hybrid phantoms-takes advantage of the best features of stylized and voxel phantoms-flexibility and anatomical realism, respectively. In the current study, hybrid computational phantoms representing reference 15-year male and female body anatomy and anthropometry are presented. For the male phantom, organ contours were extracted from the University of Florida (UF) 14-year series B male voxel phantom, while for the female phantom, original computed tomography (CT) data from two 14-year female patients were used. Polygon mesh models for the major organs and tissues were reconstructed for nonuniform rational B-spline (NURBS) surface modeling. The resulting NURBS/polygon mesh models representing body contour and internal anatomy were matched to anthropometric data and reference organ mass data provided by the Centers for Disease Control and Prevention (CDC) and the International Commission on Radiation Protection (ICRP), respectively. Finally, two hybrid 15-year male and female phantoms were completed where a total of eight anthropometric data categories were matched to standard values within 4% and organ masses matched to ICRP data within 1% with the exception of total skin. To highlight the flexibility of the hybrid phantoms, 10th and 90th weight percentile 15-year male and female phantoms were further developed from the 50th percentile phantoms through adjustments in the body contour to match the total body masses given in CDC pediatric growth curves. The resulting six NURBS phantoms, male and female phantoms representing their 10th, 50th, and 90th weight percentiles, were used to investigate the influence of body fat distributions on internal organ doses following CT imaging. The phantoms were exposed to multislice chest and abdomen helical CT scans, and in-field organ absorbed doses were calculated. The results demonstrated that the use of traditional stylized phantoms yielded organ dose estimates that deviate from those given by the UF reference hybrid phantoms by up to a factor of 2. The study also showed that use of reference, or 50th percentile, phantoms to assess organ doses in underweight 15-year-old children would not lead to significant organ dose errors (typically less than 10%). However, more significant errors were noted (up to approximately 30%) when reference phantoms are used to represent overweight children in CT imaging dosimetry. These errors are expected to only further increase as one considers CT organ doses in overweight and obese individuals of the adult patient population, thus emphasizing the advantages of patient-sculptable phantom technology. PMID:18649470

Lee, Choonsik; Lodwick, Daniel; Williams, Jonathan L; Bolch, Wesley E

2008-06-01

282

Hybrid computational phantoms of the 15-year male and female adolescent: Applications to CT organ dosimetry for patients of variable morphometry  

PubMed Central

Currently, two classes of the computational phantoms have been developed for dosimetry calculation: (1) stylized (or mathematical) and (2) voxel (or tomographic) phantoms describing human anatomy through mathematical surface equations and three-dimensional labeled voxel matrices, respectively. Mathematical surface equations in stylized phantoms provide flexibility in phantom design and alteration, but the resulting anatomical description is, in many cases, not very realistic. Voxel phantoms display far better anatomical realism, but they are limited in terms of their ability to alter organ shape, position, and depth, as well as body posture. A new class of computational phantoms—called hybrid phantoms—takes advantage of the best features of stylized and voxel phantoms—flexibility and anatomical realism, respectively. In the current study, hybrid computational phantoms representing reference 15-year male and female body anatomy and anthropometry are presented. For the male phantom, organ contours were extracted from the University of Florida (UF) 14-year series B male voxel phantom, while for the female phantom, original computed tomography (CT) data from two 14-year female patients were used. Polygon mesh models for the major organs and tissues were reconstructed for nonuniform rational B-spline (NURBS) surface modeling. The resulting NURBS?polygon mesh models representing body contour and internal anatomy were matched to anthropometric data and reference organ mass data provided by the Centers for Disease Control and Prevention (CDC) and the International Commission on Radiation Protection (ICRP), respectively. Finally, two hybrid 15-year male and female phantoms were completed where a total of eight anthropometric data categories were matched to standard values within 4% and organ masses matched to ICRP data within 1% with the exception of total skin. To highlight the flexibility of the hybrid phantoms, 10th and 90th weight percentile 15-year male and female phantoms were further developed from the 50th percentile phantoms through adjustments in the body contour to match the total body masses given in CDC pediatric growth curves. The resulting six NURBS phantoms, male and female phantoms representing their 10th, 50th, and 90th weight percentiles, were used to investigate the influence of body fat distributions on internal organ doses following CT imaging. The phantoms were exposed to multislice chest and abdomen helical CT scans, and in-field organ absorbed doses were calculated. The results demonstrated that the use of traditional stylized phantoms yielded organ dose estimates that deviate from those given by the UF reference hybrid phantoms by up to a factor of 2. The study also showed that use of reference, or 50th percentile, phantoms to assess organ doses in underweight 15-year-old children would not lead to significant organ dose errors (typically less than 10%). However, more significant errors were noted (up to ?30%) when reference phantoms are used to represent overweight children in CT imaging dosimetry. These errors are expected to only further increase as one considers CT organ doses in overweight and obese individuals of the adult patient population, thus emphasizing the advantages of patient-sculptable phantom technology.

Lee, Choonsik; Lodwick, Daniel; Williams, Jonathan L.; Bolch, Wesley E.

2008-01-01

283

Male Breast Cancer  

Microsoft Academic Search

SummaryBreast cancer is a rare disease in men representing nearly 1% of the total breast cancer cases worldwide. Due to the low incidence, there are no randomized clinical studies giving information on the optimal diagnostics and therapy for male breast cancer patients. Therefore, treatment recommendations are derived from established guidelines for breast cancer in women. However, the lack of awareness

Christian Rudlowski

2008-01-01

284

Ethnic differences in mortality of male and female patients surviving acute myocardial infarction: Long-term follow-up of 5,700 patients  

Microsoft Academic Search

In migrant countries, ethnic origin may represent a complex of cultural, behavioral and possibly genetic differences. These have been shown to influence acute myocardial infarction (AMI) incidence. How ethnic origin may affect survival after AMI is unknown. Data from 5,692 patients included in the Secondary Prevention Reinfarction Israeli Nifedipine Trial (SPRINT) registry were analyzed. Patients were divided into eight different

David Harpaz; E. Wolfson

1997-01-01

285

Dermafrac(TM): An Innovative New Treatment for Periorbital Melanosis in a Dark-Skinned Male Patient  

PubMed Central

Periorbital melanosis (under eye dark circles) is an often idiopathic cosmetically disturbing condition that is poorly responsive to currently available treatment modalities. We present the case of a 48-year-old man (skin phototype V) with significant idiopathic periorbital melanosis and who had good to excellent reduction in periorbital melanosis with the new DermaFrac™, which combines microneedling with simultaneous infusion of a serum containing active ingredients. The possible mechanisms of benefit are discussed. DermaFrac™ may be an innovative and effective new treatment option for patients with periorbital melanosis.

Sahni, Kanika; Kassir, Martin

2013-01-01

286

Congenital adrenal hypoplasia and male pseudohermaphroditism due to DAX1 mutation, SF1 mutation or neither: a patient report.  

PubMed

A 15 year-old African American phenotypic female with congenital adrenal hypoplasia and intra-abdominal testes is described; she received cortisone acetate, 9alpha-Florinef, Premarin and Provera for maintenance therapy. Evaluation for DAX1, SF1 mutations using Southern blotting, PCR, PCR amplification, coding sequences, and splice site analyses have not detected any genetic abnormalities. While only 30% of the reported DAX1 mutation defects have been identified by a variety of genetic laboratory techniques, it remains probable that this unusual patient has either a DAX1 or SF1 mutation defect. A Wnt-4 defect was not evaluated. PMID:15379426

AvRuskin, Theodore W; Krishnan, Narayana; Juan, Christina S

2004-08-01

287

Delayed diagnosis of Kearns-Sayre syndrome in a 38-year-old male patient: a case report.  

PubMed

Kearns-Sayre syndrome is a rare disorder caused by mitochondrial deoxyribonucleic acid deletion. It is characterized by a triad of progressive external ophthalmoplegia, initial symptoms that develop before the age of 20 years, and pigmentary retinopathy. Multisystem involvement is frequently associated with those features. Ragged red fibers can be identified during histopathologic examination and confirmed by electron microscopy. In this article, the case of a 38-year-old man with Kearns-Sayre syndrome in whom diagnosis was delayed despite abundant clinical evidence is presented. A brief review of clinical and laboratory findings in patients with that disorder is also provided. PMID:18205082

Yerdelen, Deniz; Koc, Filiz; Koc, Zafer

2008-02-01

288

Male infertility microsurgical training  

PubMed Central

Microsurgical training is imperative for urologists and clinical andrologists specializing in male infertility. Success in male infertility microsurgery is heavily dependent on the surgeon's microsurgical skills. Laboratory-based practice to enhance microsurgical skills improves the surgeon's confidence, and reduces stress and operating time, benefiting both the patient and the surgeon. This review provides guidelines for setting up a microsurgical laboratory to develop and enhance microsurgical skills using synthetic and animal models. The role of emerging techniques, such as robotic-assisted microsurgery, is also discussed.

Mehta, Akanksha; Li, Philip S

2013-01-01

289

Male infertility microsurgical training.  

PubMed

Microsurgical training is imperative for urologists and clinical andrologists specializing in male infertility. Success in male infertility microsurgery is heavily dependent on the surgeon's microsurgical skills. Laboratory-based practice to enhance microsurgical skills improves the surgeon's confidence, and reduces stress and operating time, benefiting both the patient and the surgeon. This review provides guidelines for setting up a microsurgical laboratory to develop and enhance microsurgical skills using synthetic and animal models. The role of emerging techniques, such as robotic-assisted microsurgery, is also discussed. PMID:23160265

Mehta, Akanksha; Li, Philip S

2012-11-19

290

Males and Females with Eating Disorders  

Microsoft Academic Search

In this study, 15 male and 15 female patients with serious eating disorders were compared. The two groups were similar in terms of demographics, comorbid conditions, and physiological complications. All three males who had bone density assessed had significant osteopenia. Abuse histories were obtained from 10 males and 10 females; childhood sexual abuse was as common among males as among

Pauline S. Powers; Eve G. Spratt

1994-01-01

291

Proteomic study of serum using gel chromatography and MALDI-TOF MS reveals diagnostic biomarkers in male patients with liver-cancer  

NASA Astrophysics Data System (ADS)

Human serum has been widely employed clinically for diagnosing various fatal diseases. However, the concentration of most proteins in human serum is too low to be directly measured using normal analytical methods. In order to obtain reliable analytical results from proteomic analysis of human serum, appropriate sample preparation is essential. A combined off-line analytical technique of gel chromatography and matrix-assisted laser desorption ionization/time of flight mass spectrometry (MALDI-TOF MS) has been successfully established to separate proteins for MS analysis. Using these combined techniques, 176 mass signal peaks of proteins/peptides were found in 6 of 18 fractions from normal male serum (NMS) in the presence of buffer consisting of NH4HCO3 and acetonitrile. A simple gel chromatography column packed with Sephadex G-50 removed most signal-suppressing compounds such as salts and high abundance proteins (HAP). The molecular mass to charge (m/z) ratios of differential peptides revealed in serum of male patient with liver-cancer (LCMPS) compared to NMS were 5365, 5644 and 6462, and these peptides can be used as biomarkers to clinically diagnose liver-cancer. The simple and convenient chromatographic method described here is not only superior to recently described HPLC separation for MS analysis, but also reveals many novel and significant serum biomarkers for the clinical diagnosis of various diseases.

Zeng, Xin-Hua; Huang, He-Qing; Chen, Dong-Shi; Jin, Hong-Wei; Huang, Hui-Ying

2007-03-01

292

Genetic Testing of Male Infertility  

Microsoft Academic Search

\\u000a Patients with severe male factor are more likely to be carriers of chromosomal abnormalities both in their sperm and in their\\u000a lymphocytes. These abnormalities include numerical alterations, structural alterations, and Y chromosome microdeletions. Gene\\u000a mutations that cause male infertility and studies identifying polymorphic regions that, in conjunction with environmental\\u000a factors, may be associated with male infertility have been described. Until

Csilla Krausz

293

Optimal treatment with systemic chemotherapy, complete surgical excision and hyperthermic intraperitoneal chemotherapy for a desmoplastic small round cell tumor in an adult male patient.  

PubMed

Desmoplastic small round cell tumor (DSRCT) is a very rare but aggressive malignancy. It is usually observed in males during adolescent and early adulthood. The tumor primarily affects the intra-abdominal serosal and is characterized by distinctive histological and immunophenotypic features and by the specific reciprocal translocation EWS-WT1. Prognosis is mainly poor with a mean survival approximately of 2.5 years. However, long-term survivals have been reported using aggressive multimodal therapy based on complete surgical excision, systemic chemotherapy and radiotherapy. The addition of hyperthermic intraperitoneal chemotherapy in the multimodal approach has been reported in very few cases but no effect on survival has been clearly demonstrated. We report a case of a 51-year old adult patient presenting with a DSRCT treated with aggressive therapy based on systemic chemotherapy, complete cytoreductive surgery associated with hyperthermic intraperitoneal chemotherapy, resulting in a long term survival of 4 years. PMID:20537477

Lauridant-Philippin, G; Ledem, N; Lemoine, F; Gouerant, S; Guillemet, C; Michel, P; Scotte, M; Di Fiore, F

2010-06-02

294

Determination of cadmium in whole blood and scalp hair samples of Pakistani male lung cancer patients by electrothermal atomic absorption spectrometer.  

PubMed

A large number of epidemiologic studies have been undertaken to identify potential risk factors for cancer, amongst which the association with cadmium has received considerable attention. There is compelling evidence in support of positive associations between cadmium and risk of lung cancer. In present study we measured the concentration of Cd in whole blood and scalp hair samples of 120 male lung cancer patients (smokers) and 150 controls or referents (smokers and nonsmokers) from different cities of Pakistan. Both referents and patients were of same age group (ranged 40-70 years), socio-economic status, localities and dietary habits. The scalp hair and whole blood samples were oxidized by 65% nitric acid: 30% hydrogen peroxide (2:1) ratio in microwave oven. To check the validity of the proposed method, a conventional wet acid digestion method was used to obtain total Cd concentration in certified samples of human hair BCR 397 and Clincheck control-lyophilized human whole blood. All digests were analyzed for Cd concentration by electrothermal atomic absorption spectrometer (ETAAS). The results of this study showed that the average Cd concentration was higher in the blood and scalp hair of lung cancer patients at different stages as compared to controls (p<001). The smoker referents have high level of Cd in both biological samples as compared to nonsmoker subjects. These results illustrate that the patients who continued smoking after confirmed diagnosis of lung cancer have 34.2-67.26 and 22.4-57.3% more Cd in blood samples and scalp hair than lung cancer patients who cease smoking. This study is compelling evidence in support of positive associations between cadmium, cigarette smoking and lung cancer risk. PMID:17919685

Kazi, T G; Memon, A R; Afridi, H I; Jamali, M K; Arain, M B; Jalbani, N; Sarfraz, R A

2007-10-04

295

Magnetic resonance imaging correlates of first-episode psychosis in young adult male patients: combined analysis of grey and white matter  

PubMed Central

Background Several patterns of grey and white matter changes have been separately described in young adults with first-episode psychosis. Concomitant investigation of grey and white matter densities in patients with first-episode psychosis without other psychiatric comorbidities that include all relevant imaging markers could provide clues to the neurodevelopmental hypothesis in schizophrenia. Methods We recruited patients with first-episode psychosis diagnosed according to the DSM-IV-TR and matched controls. All participants underwent magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) analysis and mean diffusivity voxel-based analysis (VBA) were used for grey matter data. Fractional anisotropy and axial, radial and mean diffusivity were analyzed using tract-based spatial statistics (TBSS) for white matter data. Results We included 15 patients and 16 controls. The mean diffusivity VBA showed significantly greater mean diffusivity in the first-episode psychosis than in the control group in the lingual gyrus bilaterally, the occipital fusiform gyrus bilaterally, the right lateral occipital gyrus and the right inferior temporal gyrus. Moreover, the TBSS analysis revealed a lower fractional anisotropy in the first-episode psychosis than in the control group in the genu of the corpus callosum, minor forceps, corticospinal tract, right superior longitudinal fasciculus, left middle cerebellar peduncle, left inferior longitudinal fasciculus and the posterior part of the fronto-occipital fasciculus. This analysis also revealed greater radial diffusivity in the first-episode psychosis than in the control group in the right corticospinal tract, right superior longitudinal fasciculus and left middle cerebellar peduncle. Limitations The modest sample size and the absence of women in our series could limit the impact of our results. Conclusion Our results highlight the structural vulnerability of grey matter in posterior areas of the brain among young adult male patients with first-episode psychosis. Moreover, the concomitant greater radial diffusivity within several regions already revealed by the fractional anisotropy analysis supports the idea of a late myelination in patients with first-episode psychosis.

Ruef, Anne; Curtis, Logos; Moy, Guenael; Bessero, Severine; Ba, Maryse Badan; Lazeyras, Francois; Lovblad, Karl-Olof; Haller, Sven; Malafosse, Alain; Giannakopoulos, Panteleimon; Merlo, Marco

2012-01-01

296

The association study of polymorphisms in DAT, DRD2, and COMT genes and acute extrapyramidal adverse effects in male schizophrenic patients treated with haloperidol.  

PubMed

Extrapyramidal symptoms (EPSs) are common adverse effects of antipsychotics. The development of acute EPSs could depend on the activity of dopaminergic system and its gene variants. The aim of this study was to determine the association between dopaminergic type 2 receptor (DRD2) dopamine transporter (SLC6A3) and catechol-O-methyltransferase (COMT) gene polymorphisms and acute EPSs in 240 male schizophrenic patients treated with haloperidol (15-mg/d) over a period of 2 weeks. Acute EPSs were assessed with Simpson-Angus Scale. Three dopaminergic gene polymorphisms, the DRD2 Taq1A, the SLC6A3 VNTR, and the COMT Val158Met, were determined. Extrapyramidal symptoms occurred in 116 (48.3%) of patients. Statistically significant associations were found for SLC6A3 VNTR and COMT Val158Met polymorphisms and EPS susceptibility. Patients with SLC6A3 9/10 genotype had almost twice the odds to develop EPSs compared with those with all other SLC6A3 genotypes (odds ratio, 1.9; 95% confidence interval, 1.13-3.30), and patients with COMT Val/Met genotype had 1.7 times greater odds to develop EPSs than those with all other COMT genotypes (odds ratio, 1.7; 95% confidence interval, 1.01-2.88). There was no statistically significant association between genotype and allele frequencies of DRD2, SLC6A3, or COMT polymorphisms and the development of particular EPSs.In conclusion, the results of the present study showed for the first time the association between acute haloperidol-induced EPSs and SLC6A3 VNTR and COMT Val158Met polymorphisms. Although the precise biological mechanisms underlying these findings are not yet understood, the results suggest that the dopaminergic gene variations could predict the vulnerability to the development of the acute EPSs in haloperidol-treated schizophrenic patients. PMID:23963056

Zivkovi?, Maja; Mihaljevi?-Peles, Alma; Bozina, Nada; Sagud, Marina; Nikolac-Perkovic, Matea; Vuksan-Cusa, Bjanka; Muck-Seler, Dorotea

2013-10-01

297

Long-term nephrostomy in an adult male spinal cord injury patient who had normal upper urinary tracts but developed bilateral hydronephrosis following penile sheath drainage: pyeloplasty and balloon dilatation of ureteropelvic junction proved futile: a case report  

Microsoft Academic Search

INTRODUCTION: The consequences of spinal cord injury upon urinary bladder are readily recognised by patients and health care professionals, since neuropathic bladder manifests itself as urinary incontinence, or retention of urine. But health care professionals and persons with spinal cord injury may not be conversant with neuropathic dysmotility affecting the ureter and renal pelvis. We report an adult male patient

Subramanian Vaidyanathan; Bakul M Soni; Peter L Hughes; Gurpreet Singh; Paul Mansour; Tun Oo

2009-01-01

298

Decisions to use complementary and alternative medicine (CAM) by male cancer patients: information-seeking roles and types of evidence used  

PubMed Central

Background Complementary and Alternative Medicine (CAM) is increasingly popular with cancer patients and yet information provision or discussion about CAM by health professionals remains low. Previous research suggests that patients may fear clinicians' 'disapproval' if they raise the subject of CAM, and turn to other sources to acquire information about CAM. However, little empirical research has been conducted into how cancer patients acquire, and, more importantly evaluate CAM information before deciding which CAM therapies to try. Methods Qualitative study, comprising semi-structured interviews with 43 male cancer patients of varying ages, cancer type and stage of illness, 34 of whom had used CAM. They were recruited from a range of NHS and non-NHS settings in Bristol, England. Results As a result of the lack of CAM information from health professionals, men in this study became either 'pro-active seekers' or 'passive recipients' of such information. Their main information resource was the 'lay referral' network of family, friends and acquaintances, especially females. 'Traditional' information sources, including books, magazines, leaflets and the media were popular, more so in fact than the internet. Views on the internet ranged from enthusiasm or healthy scepticism through to caution or disinterest. CAM information was generally regarded as 'empowering' as it broadened treatment and self-care options. A minority of participants were information averse fearing additional choices that might disrupt their fragile ability to cope. There was general consensus that CAM information should be available via the NHS, to give it a 'stamp of approval', which combined with guidance from informed health professionals, could help patients to make 'guided' choices. However, a small minority of these men valued the independence of CAM from the NHS and deliberately sought 'alternative' information sources and treatment options. Men were selective in identifying particular therapies to use and sceptical about others, basing their choices on forms of 'evidence' that were personally meaningful: personal stories of individuals who had been helped by CAM; the long history and enduring popularity of some therapies; the plausibility of the mechanism of action; a belief or trust in individual therapies or their providers; scientific evidence. Scientific evidence ranked low in the men's personal decision-making about CAM, while it was recognised as important for NHS support for CAM. Conclusion These male cancer patients valued the support and guidance of 'trusted individuals' in making choices about CAM. Trusted health professionals could also play a significant role in helping patients to make informed choices. Any such dialogue must, however, acknowledge the different standards of evidence used by patients and clinicians to evaluate the benefits or otherwise of CAM therapies. Such open communication could help to foster an environment of mutual trust where patients are encouraged to discuss their interest in CAM, rather than perpetuate covert, undisclosed use of CAM with its attendant potential hazards.

Evans, Maggie; Shaw, Alison; Thompson, Elizabeth A; Falk, Stephen; Turton, Pat; Thompson, Trevor; Sharp, Deborah

2007-01-01

299

Extension of RPI-adult male and female computational phantoms to obese patients and a Monte Carlo study of the effect on CT imaging dose.  

PubMed

Although it is known that obesity has a profound effect on x-ray computed tomography (CT) image quality and patient organ dose, quantitative data describing this relationship are not currently available. This study examines the effect of obesity on the calculated radiation dose to organs and tissues from CT using newly developed phantoms representing overweight and obese patients. These phantoms were derived from the previously developed RPI-adult male and female computational phantoms. The result was a set of ten phantoms (five males, five females) with body mass indexes ranging from 23.5 (normal body weight) to 46.4 kg m(-2) (morbidly obese). The phantoms were modeled using triangular mesh geometry and include specified amounts of the subcutaneous adipose tissue and visceral adipose tissue. The mesh-based phantoms were then voxelized and defined in the Monte Carlo N-Particle Extended code to calculate organ doses from CT imaging. Chest-abdomen-pelvis scanning protocols for a GE LightSpeed 16 scanner operating at 120 and 140 kVp were considered. It was found that for the same scanner operating parameters, radiation doses to organs deep in the abdomen (e.g., colon) can be up to 59% smaller for obese individuals compared to those of normal body weight. This effect was found to be less significant for shallow organs. On the other hand, increasing the tube potential from 120 to 140 kVp for the same obese individual resulted in increased organ doses by as much as 56% for organs within the scan field (e.g., stomach) and 62% for those out of the scan field (e.g., thyroid), respectively. As higher tube currents are often used for larger patients to maintain image quality, it was of interest to quantify the associated effective dose. It was found from this study that when the mAs was doubled for the obese level-I, obese level-II and morbidly-obese phantoms, the effective dose relative to that of the normal weight phantom increased by 57%, 42% and 23%, respectively. This set of new obese phantoms can be used in the future to study the optimization of image quality and radiation dose for patients of different weight classifications. Our ultimate goal is to compile all the data derived from these phantoms into a comprehensive dosimetry database defined in the VirtualDose software. PMID:22481470

Ding, Aiping; Mille, Matthew M; Liu, Tianyu; Caracappa, Peter F; Xu, X George

2012-04-05

300

Extension of RPI-adult male and female computational phantoms to obese patients and a Monte Carlo study of the effect on CT imaging dose  

PubMed Central

Although it is known that obesity has a profound effect on x-ray computed tomography (CT) image quality and patient organ dose, quantitative data describing this relationship are not currently available. This study examines the effect of obesity on the calculated radiation dose to organs and tissues from CT using newly developed phantoms representing overweight and obese patients. These phantoms were derived from the previously developed RPI-adult male and female computational phantoms. The result was a set of ten phantoms (five males, five females) with body mass indexes ranging from 23.5 (normal body weight) to 46.4 kg m?2 (morbidly obese). The phantoms were modeled using triangular mesh geometry and include specified amounts of the subcutaneous adipose tissue and visceral adipose tissue. The mesh-based phantoms were then voxelized and defined in the Monte Carlo N-Particle Extended code to calculate organ doses from CT imaging. Chest–abdomen–pelvis scanning protocols for a GE LightSpeed 16 scanner operating at 120 and 140 kVp were considered. It was found that for the same scanner operating parameters, radiation doses to organs deep in the abdomen (e.g., colon) can be up to 59% smaller for obese individuals compared to those of normal body weight. This effect was found to be less significant for shallow organs. On the other hand, increasing the tube potential from 120 to 140 kVp for the same obese individual resulted in increased organ doses by as much as 56% for organs within the scan field (e.g., stomach) and 62% for those out of the scan field (e.g., thyroid), respectively. As higher tube currents are often used for larger patients to maintain image quality, it was of interest to quantify the associated effective dose. It was found from this study that when the mAs was doubled for the obese level-I, obese level-II and morbidly-obese phantoms, the effective dose relative to that of the normal weight phantom increased by 57%, 42% and 23%, respectively. This set of new obese phantoms can be used in the future to study the optimization of image quality and radiation dose for patients of different weight classifications. Our ultimate goal is to compile all the data derived from these phantoms into a comprehensive dosimetry database defined in the VirtualDose software.

Ding, Aiping; Mille, Matthew M; Liu, Tianyu; Caracappa, Peter F; Xu, X George

2012-01-01

301

Cigarette smoking, body mass index associated with the risks of age-related cataract in male patients in northeast China  

PubMed Central

AIM To determine the association between cigarettes smoking, body mass index (BMI) and the risk of age-related cataract (ARC) in middle-aged and elderly men in Northeast China. METHODS A hospital-based case control study was conducted. Cases (n =362) were men who had surgically treated ARC, 45-85 years old; controls frequency-matched (n =362) were men who had been admitted to the same hospital as cases for other diseases not related with eye diseases. Cases and controls were matched with 1:1. The cases and controls were interviewed during their hospital stay, using a structured interviewer-administrated questionnaire that included information on sociodemographic characteristics, socioeconomic, lifestyle habits (tobacco smoking and alcohol consumption, etc.), anthropometric measures, personal medical history, and family history of ARC in first-degree relatives, and simultaneously BMI was calculated. The odds ratios (OR) and 95% confidence intervals (CI) of ARC were estimated using multiple logistic regression models. RESULTS After adjusting for age and multiple potential confounders, higher BMI was associated with an increased risk of ARC. Cigarette smoking, years smoking or moderate cigarette smoking (1-29 cigarettes per day) had no relation with the risk of ARC (P>0.05), although patients smoking ?30 cigarettes per day had an elevated risk of ARC as compared with the non-smokers (OR=1.55, 95% CI; 1.16-2.85, P=0.026). Higher BMI was associated with an increased risk of ARC. Both overweight and obesity was associated with an obviously increased risk for surgically ARC (OR=1.55, 95% CI: 1.02-1.98, P=0.015 and OR=1.71, 95% CI: 1.32-2.39, P=0.013 respectively) compared to normal BMI. Then participants were grouped into quartiles of BMI (Q1 to Q4), compared to controls in the lowest quartile, the OR for cases in the highest quartile of BMI was 1.54 (OR=1.54, 95% CI: 1.08-2.46, P=0.022). The results of univariate analysis showed cigarette smoking was not associated with ARC formation for men with lower or normal BMI (P>0.05). Compared to the non-smokers, for men of overweight or obesity, cigarette smoking was associated with a significantly increased risk for surgically ARC (OR=2.00, 95% CI: 1.49-6.65, P=0.003 and OR=1.66, 95% CI: 1.63-13.21, P=0.002 respectively). Similarly, smokers in the highest quartile of BMI had approximately 1.5 times the risk of ARC as non-smokers in the lowest quartile (OR=1.46, 95% CI: 1.06-5.29, P<0.001). Followed multivariate models revealed that the association had never changed. CONCLUSION Current cigarette smoking is positively related to ARC only among those who smoking 30 or more cigarettes per day. For men who are both overweight and obesity, cigarette smoking is associated with a significantly increased risk for ARC.

Lu, Zhi-Quan; Sun, Wen-Hui; Yan, Jia; Jiang, Teng-Xuan; Zhai, Shu-Na; Li, Yan

2012-01-01

302

Male only Systemic Lupus  

PubMed Central

Systemic lupus erythematosus (SLE) is more common among women than men with a ratio of about 10 to 1. We undertook this study to describe familial male SLE within a large cohort of familial SLE. SLE families (two or more patients) were obtained from the Lupus Multiplex Registry and Repository. Genomic DNA and blood samples were obtained using standard methods. Autoantibodies were determined by multiple methods. Medical records were abstracted for SLE clinical data. Fluorescent in situ hybridization (FISH) was performed with X and Y centromere specific probes, and a probe specific for the toll-like receptor 7 gene on the X chromosome. Among 523 SLE families, we found five families in which all the SLE patients were male. FISH found no yaa gene equivalent in these families. SLE-unaffected primary female relatives from the five families with only-male SLE patients had a statistically increased rate of positive ANA compared to SLE-unaffected female relatives in other families. White men with SLE were 5 times more likely to have an offspring with SLE than were White women with SLE but there was no difference in this likelihood among Black men. These data suggest genetic susceptibility factors that act only in men.

Aggarwal, Rachna; Namjou, Bahram; Li, Shibo; D'Souza, Anil; Tsao, Betty P; Bruner, Ben; James, Judith A.; Scofield, R. Hal

2010-01-01

303

[Male contraception].  

PubMed

Male contraceptive drugs meeting the criteria of efficacy, easy applicability and reversibility -- and also having limited side effects -- are discussed. These drugs affect the hypothalamus, the hypophysis, the ductus deferens, and the testes. Gestagens inhibit the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Gonadotropic hormones inhibit spermatogenesis by producing intratesticular concentration of testosterone. Recently, a combination of gestagen and androgen has been used to avoid decreased libido. Oral medroxyprogesterone acetate and percutaneous testosterone produce azoospermia, but with serious side effects, i.e., hirsutism and acne; however, they can be reduced by iv administration. Cyproterone acetate inhibits androgen secretion, and a daily dosage of 5-10 mg slightly reduces the sperm count; however, higher doses can lead to thromboembolitic effects. Combining cyproterone with an androgen prevents negative effects on the libido. Buserelin administered iv or as a nasal spray stimulates the secretion of LH and FSH from the hypophysis 20-40 times more effectively than does natural LH release of the hormone (LH-RH). Gossypol exerts its inhibitory effect on the epithelium of testes, but can cause hypokalemia. It has been used successfully in a Chinese experiment involving 9000 men who received daily oral doses of 20 mg for 60-70 days. Cytostatic agents also produce azoospermia, but are not recommended. Implantation of a copper wire into the ductus deferens has been tried in animal experiments with mixed results. Vasectomy has been performed on 50 million men since the 1960's (48,000 in 1981 in Denmark). It has to be regarded as a partially irreversible operation. The oral administration of the adrenergic blocking agent, phenoxybenzamine, at the rate of 20 mg per day has produced azoospermia; however, more research is needed to understand its side effects. Finally, chlorohydrin is not usable because of its neurotoxic and nephrotoxic effects. PMID:3775919

Kjaergaard, N

1986-09-01

304

Instability of the CGG repeat and expression of the FMRI protein in a male fragile X patient with a lung tumor  

SciTech Connect

The molecular mechanism of the fragile X syndrome is based on the expansion of an CGG repeat in the 5{prime} UTR of the FMR1 gene in the majority of fragile X patients. This repeat displays instability both between individuals and within an individual. We studied the instability of the CGG repeat and the expression of the FMR1 protein (FMRP) in several different tissues derived from a male fragile X patient. Using Southern blot analysis, only a full mutation is detected in 9 of the 11 tissues tested. The lung tumor contains a methylated premutation of 160 repeats, whereas in the testis, besides the full mutation, a premutation of 60 CGG repeats is detected. Immunohistochemistry of the testis revealed expression of FMR1 in the spermatogonia only, confirming the previous finding that, in the sperm cells of fragile X patients with a full mutation in their blood cells, only a premutation is present. Immunohistochemistry of brain and lung tissue revealed that 1% of the cells are expressing the FMRP. PCR analysis demonstrated the presence of a premutation of 160 repeats in these FMR1-expressing cells. This indicates that the tumor was derived from a lung cell containing a premutation. Remarkably, despite the methylation of the EagI and BssHII sites, FMRP expression is detected in the tumor. Methylation of both restriction sites has thus far resulted in a 100% correlation with the lack of FMR1 expression, but the results found in the tumor suggest that the CpGs in these restriction sites are not essential for regulation of FMR1 expression. This indicates a need for a more accurate study of the exact promoter of FMR1. 54 refs., 4 figs.

Graaff, E. de; Willemsen, R. [Erasmus Univ. Rotterdam (Netherlands); Zhong, N. [New York State Institute for Basic Research, Staten Island, NY (United States)] [and others

1995-09-01

305

Bone marrow transplantation in a patient with chronic myeloid leukemia and achondroplasia.  

PubMed

A 25-year-old female with achondroplastic dwarfism, diagnosed when she was six months old, was diagnosed with chronic myeloid leukemia (CML) in chronic phase with 9;22 translocation, A2B3 gene rearrangement and a Sokal index of 0.5. A recombinant interferon-alpha 2A treatment was started in October '94, which obtained a hematological, but not a karyotypic, response at the 6th and 12th month. In August '94, the patient was submitted to allogeneic bone marrow transplantation (alloBMT) from a 36-year-old matched sibling. The procedure was well tolerated. Disease-free survival (DFS) and overall survival (OS) were 21 and 39 months, respectively. We have not found any reported cases of achondroplastic patients submitted to alloBMT in the literature or in the IBMT Registry. PMID:9499671

Geromin, A; Sperotto, A; Fanin, R; Damiani, D; Michieli, M; Baccarani, M

306

Complementary and alternative medicine in epistaxis: a point worth considering during the patient's history.  

PubMed

A large number of patients take complementary and alternative medicine (CAM) for a variety of reasons, but most do not inform their physicians. This has implications for safety, as many forms of herbal CAM are thought to have a variety of side-effects and may interact with conventional medicines with potentially adverse consequences. We present the case of an otherwise healthy 25-year-old man with difficult-to-control epistaxis. On further questioning, we learnt that he had recently started self-medicating with a combination of aspirin, garlic tablets and milk thistle. Garlic increases bleeding time and milk thistle alters the function of liver enzymes, both of which may have contributed to the difficulty in his management of epistaxis. This case highlights the importance of asking about CAM use when taking a patient's history, as it may have implications for management. PMID:19451826

Shakeel, Muhammad; Trinidade, Aaron; McCluney, Neil; Clive, Brewis

2010-02-01

307

Cancer of the male breast.  

PubMed

The purpose of this study was to investigate the biological behavior of male breast cancer. We evaluated 11 cases of male breast cancer with respect to tumor growth, extent of disease, hormone receptor status, and histological grade of the malignancy, in comparison with 241 cases of female breast cancer. The duration of symptoms was 8.6 +/- 9.1 months in males and 8.5 +/- 18.6 months in females. The incidences of stages I, II, and III were 46%, 27%, and 27%, respectively, in male breast cancer, and 38%, 49%, and 13% in female breast cancer. Metastasis to the lymph node was negative in 60% of the male patients and 54% of the female patients. All cases of male breast cancer were histologically grade I according to Bloom's classification; the histological grades were as follows for the female breast cancer cases: grade I in 99 patients, grade II in 87, and grade III in 55. The rates of hormone receptor positively were 89% for ER and 86% for PgR in male breast cancer, and 64% for ER and 44% for PgR in female breast cancer. Therefore, there was no significant difference in the growth of male breast cancer and female breast cancer, but in male breast cancer the rate of hormone receptor positivity was high, endocrine therapy was effective, and the histological grade was low. Accordingly, the result following appropriate treatment of male breast cancer should be at least comparable to the results with female breast cancer. PMID:2370802

Morimoto, T; Komaki, K; Yamakawa, T; Tanaka, T; Oomine, Y; Konishi, Y; Mori, T; Monden, Y

1990-07-01

308

The Mitochondrial DNA Northeast Asia CZD Haplogroup Is Associated with Good Disease-Free Survival among Male Oral Squamous Cell Carcinoma Patients  

PubMed Central

Reprogramming of energy metabolism in cancer cells has been directly/indirectly linked to mitochondria and mitochondrial functional defects and these changes seem to contribute to the development and progression of cancer. Studies have indicated that mitochondrial DNA haplogroups are associated with risk in relation to various diseases including cancer. However, few studies have examined the effect of haplogroups on cancer prognosis outcome. In order to explore the role of haplogroups on oral squamous cell carcinoma (OSCC) prognosis, the mitochondrial genomes of 300 male OSCC patients were comprehensively analyzed by direct sequencing. They were then haplotyped and grouped into four major geographic haplogroups, namely the East Asia AN, Southeast Asia RBF, East Asia MGE and Northeast Asia CZD groups. The Kaplan-Meier plot analysis indicated that individuals who were members of the CZD haplogroup showed a significant association with better disease-free survival (DFS) than the other three haplogroups and this phenomenon still existed after adjusting for tumor stage, differentiation and age at diagnosis (hazard ratio?=?0.55; 95% CI?=?0.36–0.84). In addition, an interaction between membership of the RBF haplogroup and radiotherapy/chemo-radiotherapy in DFS was also identified. The results strongly support the hypothesis that an individual’s haplogroup, by defining their genomic background, plays an important role in tumor behavior and mitochondrially-targeted anticancer drugs are promising future therapeutic approaches.

Lai, Chih-Hsiung; Huang, Shiang-Fu; Chen, I-How; Liao, Chun-Ta; Wang, Hung-Ming; Hsieh, Ling-Ling

2012-01-01

309

Effect of moderate-intensity exercise versus activities of daily living on 24-hour blood glucose homeostasis in male patients with type 2 diabetes.  

PubMed

OBJECTIVE To investigate the impact of activities of daily living (ADL) versus moderate-intensity endurance-type exercise on 24-h glycemic control in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Twenty males with type 2 diabetes participated in a randomized crossover study consisting of three experimental periods of 3 days each. Subjects were studied under sedentary control conditions, and under conditions in which prolonged sedentary time was reduced either by three 15-min bouts of ADL (postmeal strolling, ?3 METs) or by a single 45-min bout of moderate-intensity endurance-type exercise (?6 METs). Blood glucose concentrations were assessed by continuous glucose monitoring, and plasma insulin concentrations were determined in frequently sampled venous blood samples. RESULTS Hyperglycemia (glucose >10 mmol/L) was experienced for 6 h 51 min ±1 h 4 min per day during the sedentary control condition and was significantly reduced by exercise (4 h 47 min ± 1 h 2 min; P < 0.001), but not by ADL (6 h 2 min ± 1 h 16 min; P = 0.67). The cumulative glucose incremental areas under the curve (AUCs) of breakfast, lunch, and dinner were, respectively, 35 ± 5% (P < 0.001) and 17 ± 6% (P < 0.05) lower during the exercise and ADL conditions compared with the sedentary condition. The insulin incremental AUCs were, respectively, 33 ± 4% (P < 0.001) and 17 ± 5% (P < 0.05) lower during the exercise and ADL conditions compared with the sedentary condition. CONCLUSIONS When matched for total duration, moderate-intensity endurance-type exercise represents a more effective strategy to improve daily blood glucose homeostasis than repeated bouts of ADL. Nevertheless, the introduction of repeated bouts of ADL during prolonged sedentary behavior forms a valuable strategy to improve postprandial glucose handling in patients with type 2 diabetes. PMID:24041682

van Dijk, Jan-Willem; Venema, Maarten; van Mechelen, Willem; Stehouwer, Coen D A; Hartgens, Fred; van Loon, Luc J C

2013-09-16

310

A Laboratory Study of Sleep and Dreaming in a Case of Asperger's Syndrome  

Microsoft Academic Search

Asperger's Syndrome (AS) is a pervasive developmental disorder whose continuity with High-Functioning Autism is still a matter of debate. Clinical observations suggest that patients with AS may present the same sleep disorders as autistic patients, including difficulties in initiating and maintaining sleep as well as poor dream recall. We recorded the sleep of a 25-year-old male patient with AS for

Roger Godbout; Cybèle Bergeron; Emmanuel Stip; Laurent Mottron

1998-01-01

311

Anorectal stenosis after treatment with tumor necrosis factor ? antibodies: a case series  

Microsoft Academic Search

INTRODUCTION: We identified three patients who developed anorectal stenosis after successful treatment with anti-tumor necrosis factor ? (anti-TNF-?) agents. CASE PRESENTATION: Two patients, a 24-year-old Irish Caucasian man and a 64-year-old Irish Caucasian woman, developed symptoms attributable to anorectal stenosis four to six weeks after treatment. A further patient, a 25-year-old Irish Caucasian male, presented three years after treatment with

Eoin Slattery; Denise Keegan; Diarmuid O'Donoghue

2010-01-01

312

Use of personalized decision analysis in decision making for Palliative vs. surgical management of the oldest-old patients with localized skin cancer in a culturally sensitive environment: a case study of a 96-year-old male Taiwanese patient.  

PubMed

Clinical management of older cancer patients is challenging, especially for those in the oldest-old age group. In the Chinese culture, the preference toward noninvasive care for patients in this age group may create a difficult situation for clinicians when the cancer is potentially curable. Palliative care may not always be the obvious choice, especially if patients suffer from quality-of-life impairment because of symptoms related to progression of the untreated cancer. Balancing between higher rates of toxicities and potential gains in quality of life from anticancer therapies among the oldest old presents a real challenge in clinical practice. Decision analysis is an analytical tool that has a long history of successful application in clinical decision making. In this case study of a 96-year-old male with localized skin cancer, we demonstrate that personalized decision analysis can be a helpful tool to assist decision making in the clinical management of cancer patients in the oldest-old age group, especially in situations in which the evidence-based literature provides little guidance. This was achieved by providing information to help the key decision makers to better understand the risk-benefit trade offs and make an informed decision. We found that the option of surgical management was associated with higher expected quality-adjusted life years (0.894) than best supportive care (0.853). Based on this finding and various scenarios explored in sensitivity analyses, the family members recommended surgery for the patient. The patient recovered well from surgery and there is no evidence of recurrence to date. PMID:22917709

Chien, Chun-Ru; Shih, Ya-Chen Tina

2012-08-20

313

Clinical, Biochemical and Morphologic Diagnostic Markers in an Infant Male Pseudohermaphrodite Patient with Compound Heterozygous Mutations (G115D\\/R246W) in SRD5A2 Gene  

Microsoft Academic Search

A patient with male pseudohermaphroditism and clinical diagnosis of partial androgen insensitivity in the neonatal period was studied at pubertal age for a molecular diagnosis. Hormone studies were conducted at baseline and under hCG stimulation for testosterone and dihydrotestosterone determinations at 2 months of age. Gonadectomy was performed at 4 months. At the age of 13 years genital skin fibroblasts

Mónica Fernández-Cancio; Joan Rodó; Pilar Andaluz; María Jesús Martínez de Osaba; Francisco Rodríguez-Hierro; Cristina Esteban; Antonio Carrascosa; Laura Audí

2004-01-01

314

Unpredicted spontaneous extrusion of a renal calculus in an adult male with spina bifida and paraplegia: report of a misdiagnosis. Measures to be taken to reduce urological errors in spinal cord injury patients  

Microsoft Academic Search

BACKGROUND: A delay in diagnosis or a misdiagnosis may occur in patients with spinal cord injury (SCI) or spinal bifida as typical symptoms of a clinical condition may be absent because of their neurological impairment. CASE PRESENTATION: A 29-year old male, who was born with spina bifida and hydrocephalus, became unwell and developed a swelling and large red mark in

Subramanian Vaidyanathan; Peter L Hughes; Bhakul M Soni; Gurpreet Singh; Paul Mansour; Pradipkumar Sett

2001-01-01

315

The health and well-being of prostate cancer patients and male-to-female transsexuals on androgen deprivation therapy: A qualitative study with comments on expectations and estrogen  

Microsoft Academic Search

Both male-to-female transsexuals and advanced prostate cancer (PCa) patients are treated with androgen-suppressing drugs that have emasculating effects. Additionally, transsexuals take estrogenic compounds to feminize their bodies. We explore the quality of life of these populations, based on interviews with 12 individuals from each group. Overall, the transsexuals had a better psychological response to chemical castration than the PCa patients.

Richard J. Wassersug; Ross Gray

2011-01-01

316

The detection of urethritis pathogens among patients with the male urethritis syndrome, genital ulcer syndrome and HIV voluntary counselling and testing clients: should South Africa’s syndromic management approach be revised?  

Microsoft Academic Search

Objectives:To determine the prevalence of urethritis pathogens amongst male symptomatic urethritis (MUS) patients, genital ulcer (GUS) patients without urethritis symptoms and men requesting HIV testing at a voluntary counselling and testing (VCT) clinic.Methods:A prospective study was conducted in Johannesburg, South Africa. Men from the three groups were screened for urethritis pathogens using molecular tests. Culture for Neisseria gonorrhoeae and, initially,

V Black; P Magooa; F Radebe; M Myers; C Pillay; D A Lewis

2008-01-01

317

Male contraceptive technology for nonhuman male mammals  

Microsoft Academic Search

Contraceptive techniques applied to males have potential to mitigate diverse instances of overpopulation in human and animal populations. Different situations involving different species dictate that there is no ideal male contraceptive, and emphasizes the value of varying approaches to reducing male fertility. A majority of work in this field has focused on non-surgically destroying the testes or obstructing the epididymis,

R. A. Bowen

2008-01-01

318

Adolescent male health  

PubMed Central

Although adolescent males have as many health issues and concerns as adolescent females, they are much less likely to be seen in a clinical setting. This is related to both individual factors and the health care system itself, which is not always encouraging and set up to provide comprehensive male health care. Working with adolescent boys involves gaining the knowledge and skills to address concerns such as puberty and sexuality, substance use, violence, risk-taking behaviours and mental health issues. The ability to engage the young male patient is critical, and the professional must be comfortable in initiating conversation about a wide array of topics with the teen boy, who may be reluctant to discuss his concerns. It is important to take every opportunity with adolescent boys to talk about issues beyond the presenting complain, and let them know about confidential care. The physician can educate teens about the importance of regular checkups, and that they are welcome to contact the physician if they are experiencing any concerns about their health or well-being. Parents of preadolescent and adolescent boys should be educated on the value of regular health maintenance visits for their sons beginning in their early teen years.

Westwood, Michael; Pinzon, Jorge

2008-01-01

319

Clinical and pathologic characteristics of BRCA-positive and BRCA-negative male breast cancer patients: results from a collaborative multicenter study in Italy.  

PubMed

Recently, the number of studies on male breast cancer (MBC) has been increasing. However, as MBC is a rare disease there are difficulties to undertake studies to identify specific MBC subgroups. At present, it is still largely unknown whether BRCA-related breast cancer (BC) in men may display specific characteristics as it is for BRCA-related BC in women. To investigate the clinical-pathologic features of MBC in association with BRCA mutations we established a collaborative Italian Multicenter Study on MBC with the aim to recruit a large series of MBCs. A total of 382 MBCs, including 50 BRCA carriers, were collected from ten Italian Investigation Centres covering the whole country. In MBC patients, BRCA2 mutations were associated with family history of breast/ovarian cancer (p<0.0001), personal history of other cancers (p=0.044) and contralateral BC (p=0.001). BRCA2-associated MBCs presented with high tumor grade (p=0.001), PR-(p=0.026) and HER2+ (p=0.001) status. In a multivariate logistic model BRCA2 mutations showed positive association with personal history of other cancers (OR 11.42, 95% CI 1.79-73.08) and high tumor grade (OR 4.93, 95% CI 1.02-23.88) and inverse association with PR+ status (OR 0.19, 95% CI 0.04-0.92). Based on immunohistochemical (IHC) profile, four molecular subtypes of MBC were identified. Luminal A was the most common subtype (67.7%), luminal B was observed in 26.5% of the cases and HER2 positive and triple negative were represented by 2.1% and 3.7% of tumors, respectively. Intriguingly, we found that both luminal B and HER2 positive subtypes were associated with high tumor grade (p=0.003 and 0.006, respectively) and with BRCA2 mutations (p=0.016 and 0.001, respectively). In conclusion, our findings indicate that BRCA2-related MBCs represent a subgroup of tumors with a peculiar phenotype characterized by aggressive behavior. The identification of a BRCA2-associated phenotype might define a subset of MBC patients eligible for personalized clinical management. PMID:22527108

Ottini, Laura; Silvestri, Valentina; Rizzolo, Piera; Falchetti, Mario; Zanna, Ines; Saieva, Calogero; Masala, Giovanna; Bianchi, Simonetta; Manoukian, Siranoush; Barile, Monica; Peterlongo, Paolo; Varesco, Liliana; Tommasi, Stefania; Russo, Antonio; Giannini, Giuseppe; Cortesi, Laura; Viel, Alessandra; Montagna, Marco; Radice, Paolo; Palli, Domenico

2012-04-18

320

Desmoid Tumor of the Anterior Abdominal Wall in Female Patients: Comparison with Endometriosis  

PubMed Central

In female patients presenting a tumor of the lower abdominal wall especially after cesarian section, an endometriotic tumor as well as an aggressive desmoid tumor should be considered. Symptoms in correlation with the monthly period can facilitate the presurgical differentiation between endometriosis and fibromatosis. Ultrasound reveals the typical location of both tumors and its remarkable sonographic appearance. In the clinical practice, the desmoid fibromatosis of the lower abdominal wall is a very rare disease. We present a case of a 25-year-old pregnant and discuss diagnostic and therapeutic options by a PubMed literature review. With the knowledge of the prognosis of the desmoid fibromatosis and the respective treatment options including wait and see, complete surgical resection with macroscopically free margins and adjuvant approaches is essential to avoid further interventions and progression of the locally destructive tumor.

Krentel, H.; Tchartchian, G.; De Wilde, R. L.

2012-01-01

321

Differentiating scleroderma renal crisis from other causes of thrombotic microangiopathy in a postpartum patient.  

PubMed

Thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), and scleroderma renal crisis (SRC) all present with features of thrombotic microangiopathy. Distinguishing among these entities is critical, however, as treatments differ and may be mutually exclusive. We describe the case of a 25-year-old woman with an undefined mixed connective tissue disease who presented 6 weeks post-partum with fever, transient aphasia, thrombocytopenia, hemolytic anemia, and acute kidney injury eventually requiring initiation of hemodialysis. Renal biopsy revealed thrombotic microangiopathy. Renal function did not improve despite immediate initiation of plasma exchange, and an angiotensin-converting enzyme (ACE) inhibitor was initiated following discontinuation of plasma exchange. At last follow up, she remained dialysis dependent. Due to the myriad causes of thrombotic microangiopathy and potential for diagnostic uncertainty, the patient's response to therapy should be closely monitored and used to guide modification of therapy. PMID:22579274

Abudiab, Muaz; Krause, Megan L; Fidler, Mary E; Nath, Karl A; Norby, Suzanne M

2013-10-01

322

Tumor-Like Growth of Giant Inflammatory Polyposis in a Patient with Ulcerative Colitis  

PubMed Central

We report a unique case of giant obstructing inflammatory polyposis associated with ulcerative colitis (UC). A 25-year-old Japanese man with an UC history of 2 years and 6 months was referred to our institution because of diarrhea and melena. His computed tomography scan showed marked dilation of the transverse and descending colon; therefore, we performed total colectomy. Macroscopic evaluation of the excised specimen indicated constricting lesions with giant polyposis in the transverse and descending colon. The polyposis consisted of narrow worm- or noodle-like polyps that bridged over the irregular ulcers. Histologic evaluation of the excised specimen indicated transmural inflammation with a thickened proper muscular layer overlaid with inflammatory polyposis. Based on these data, a diagnosis of giant inflammatory polyposis should be considered in patients who have had UC. Although giant inflammatory polyposis is considered benign, surgical treatment may be indicated to avoid serious complications.

Nagashima, Makoto; Sugishita, Yui; Moriyama, Ayako; Ooshiro, Mitsuru; Kadoya, Kengo; Sato, Ayami; Kitahara, Tomoaki; Takagi, Ryuichi; Urita, Tasuku; Yoshida, Yutaka; Tanaka, Hiroshi; Oshiro, Takashi; Nakamura, Kentaro; Suzuki, Yasuo; Hiruta, Nobuyuki; Okazumi, Shinichi; Katoh, Ryoji

2013-01-01

323

Tumor-like growth of giant inflammatory polyposis in a patient with ulcerative colitis.  

PubMed

We report a unique case of giant obstructing inflammatory polyposis associated with ulcerative colitis (UC). A 25-year-old Japanese man with an UC history of 2 years and 6 months was referred to our institution because of diarrhea and melena. His computed tomography scan showed marked dilation of the transverse and descending colon; therefore, we performed total colectomy. Macroscopic evaluation of the excised specimen indicated constricting lesions with giant polyposis in the transverse and descending colon. The polyposis consisted of narrow worm- or noodle-like polyps that bridged over the irregular ulcers. Histologic evaluation of the excised specimen indicated transmural inflammation with a thickened proper muscular layer overlaid with inflammatory polyposis. Based on these data, a diagnosis of giant inflammatory polyposis should be considered in patients who have had UC. Although giant inflammatory polyposis is considered benign, surgical treatment may be indicated to avoid serious complications. PMID:24019769

Nagashima, Makoto; Sugishita, Yui; Moriyama, Ayako; Ooshiro, Mitsuru; Kadoya, Kengo; Sato, Ayami; Kitahara, Tomoaki; Takagi, Ryuichi; Urita, Tasuku; Yoshida, Yutaka; Tanaka, Hiroshi; Oshiro, Takashi; Nakamura, Kentaro; Suzuki, Yasuo; Hiruta, Nobuyuki; Okazumi, Shinichi; Katoh, Ryoji

2013-08-24

324

Male pattern baldness  

MedlinePLUS

Alopecia in men; Baldness - male; Hair loss in men; Androgenetic alopecia ... Male pattern baldness is related to your genes and male sex hormones. It usually follows a pattern of receding hairline and ...

325

Male Pattern Alopecia  

MedlinePLUS

newsletter | contact Share | Hair Loss, Male Pattern Baldness (Male Pattern Alopecia) Information for adults A A A This man has worsening male-pattern hair loss resulting from the medication Tenormin. Overview ...

326

Bulimia Nervosa in Males  

MedlinePLUS

... Learn / Diversity Issues / Males / Bulimia Nervosa in Males Bulimia Nervosa in Males Bulimia nervosa is a severe, life-threatening disorder characterized ... to prevent weight gain. An individual struggling with bulimia is intensely afraid of gaining weight and exhibits ...

327

Bladder agenesis in a male neonate  

Microsoft Academic Search

Bladder agenesis, especially in male, is a rare congenital anomaly. This is a case report of a male patient with several congenital anomalies including penoscrotal transposition, severe kidney's dysplasia, and agenesis of the bladder. The patient lived for 4 months and died because of severe pneumonia.

Dariusz Patkowski; Wojciech Apozna?ski; Tomasz Szyde?ko; Wojciech Jaworski; Robert ?migiel

2008-01-01

328

Bladder agenesis in a male neonate.  

PubMed

Bladder agenesis, especially in male, is a rare congenital anomaly. This is a case report of a male patient with several congenital anomalies including penoscrotal transposition, severe kidney's dysplasia, and agenesis of the bladder. The patient lived for 4 months and died because of severe pneumonia. PMID:18970912

Patkowski, Dariusz; Apozna?ski, Wojciech; Szyde?ko, Tomasz; Jaworski, Wojciech; Smigiel, Robert

2008-11-01

329

[Successful delivery following subcutaneous heparin administration in a 7-weeks pregnant patient suffering from cerebral venous thrombosis due to secondary protein S deficiency].  

PubMed

A 25-year-old, 7-weeks pregnant woman was admitted to the Nagaoka Red Cross Hospital in a state of confusion, following fever, headache and vomiting. Brain CT and MRI showed swelling in the bilateral thalami, basal ganglia and splenium of corpus callosum, and thrombosis of the internal cerebral veins and straight sinus. Initial treatment by intravenous heparin and glycerol was successful, and she regained her consciousness, leaving antegrade amnesia and childish character change. Her free protein S antigen was 32% (normal 60-127) and subsequently rose to 70% after delivery. She was diagnosed as having secondary protein S deficiency associated with pregnancy. Because warfarin can be teratogenic, subcutaneous heparin injection was prescribed in order to prevent thrombosis and the patient subsequently had a successful delivery. This was the first case in Japanese of successful delivery after subcutaneous heparin treatment in a patient with cerebral venous thrombosis. PMID:16642938

Nozaki, Hiroaki; Naruse, Satoshi; Koike, Tadashi; Okuizumi, Yuzuru; Fujita, Nobuya; Nagai, Hiroko

2006-03-01

330

A novel dosing regimen for calcium infusion in a patient of massive overdose of sustained-release nifedipine.  

PubMed

Although continuous intravenous (IV) calcium infusion is recommended for calcium channel blocker (CCB) overdose, its clinical efficacy is inconsistent and the dosage required is unclear. The authors present a case of a 25-year-old previously healthy woman with massive overdose of sustained-release nifedipine resulting in severe hypotension. The patient was successfully treated with continuous IV calcium gluconate infusion as add-on therapy. What differed this case from the previous ones is the use of an individually tailored protocol for dose titration of IV calcium infusion, in which the "optimal" calcium infusion rate was determined by achieving the lowest possible serum ionic calcium level associated with a maximal contractility (ie, cardiac power index). This strategy, resulting in a lower dosage of calcium administrated and a lower peak serum ionic Ca level achieved, seems a promising therapeutic alternative for the management of CCB overdose and deserves further investigations. PMID:23187299

Zhou, Hong; Liu, Yang; Li, Guo-Qiang; Wei, Lu-Qing

2013-03-01

331

Brief family treatment intervention to promote aftercare among male substance abusing patients in inpatient detoxification: A quasi-experimental pilot study  

Microsoft Academic Search

We developed a brief family treatment (BFT) intervention for substance abusing patients in inpatient detoxification to promote aftercare treatment post-detox. BFT consisted of meeting with the patient and a family member (spouse or parent) with whom the patient lived to review and recommend potential aftercare plans for the patient. A phone conference was used when logistics prevented an in-person family

Timothy J. O'Farrell; Marie Murphy; Jane Alter; William Fals-Stewart

2007-01-01

332

Determination of cadmium in whole blood and scalp hair samples of Pakistani male lung cancer patients by electrothermal atomic absorption spectrometer  

Microsoft Academic Search

A large number of epidemiologic studies have been undertaken to identify potential risk factors for cancer, amongst which the association with cadmium has received considerable attention. There is compelling evidence in support of positive associations between cadmium and risk of lung cancer.In present study we measured the concentration of Cd in whole blood and scalp hair samples of 120 male

T. G. Kazi; A. R. Memon; H. I. Afridi; M. K. Jamali; M. B. Arain; N. Jalbani; R. A. Sarfraz

2008-01-01

333

KNOWLEDGE, ATTITUDE AND PRACTICE OF FEMALE GENITAL MUTILATIONS AMONG MALES AND FEMALES ATTENDING OUT PATIENTS AND MCH CLINIC OF ELDER DISTRICT RURAL HOSPITAL GALGADUD REGION SOMALIA  

Microsoft Academic Search

Background : Somalia is a country that still practices Female Genital Mutilation (FGM). Female genital mutilation (FGM) constitutes all procedures, which involve partial or total removal of the external female genitalia or other injury to the female genital organs whether for cultural or any other non- therapeutic reasons. Methodology : A cross-sectional community based study was conducted among males and

A. S Shamsul; S. A Abdi Nur; I Halim; M. A Rahmah

334

Epidemiology of intentional self-poisoning in rural Sri Lanka.  

PubMed

We investigated the epidemiology of intentional self-poisoning in rural Sri Lanka by prospectively recording 2189 admissions to two secondary hospitals. Many patients were young (median age 25 years), male (57%) and used pesticides (49%). Of the 198 who died,156 were men (case fatality 12.4%) and 42 were women (4.5%). Over half of female deaths were in those under 25 years old; male deaths were spread more evenly across age groups. Oleander and paraquat caused 74% of deaths in people under 25 years old; thereafter organophosphorous pesticides caused many deaths. Although the age pattern of self-poisoning was similar to that of industrialised countries, case fatality was more than 15 times higher and the pattern of fatal self-poisoning different. PMID:16319413

Eddleston, Michael; Gunnell, David; Karunaratne, Ayanthi; de Silva, Dhammika; Sheriff, M H Rezvi; Buckley, Nick A

2005-12-01

335

Two patients with primary sellar leiomyomas, a rare entity.  

PubMed

Leiomyomas are benign smooth muscle tumors commonly found in the genitourinary or gastrointestinal tracts. Rarely, they present as primary intracranial extra-axial brain tumors. Most of these lesions have been described in immunocompromised patients, but have been found very rarely in the immunocompetent patient. We present two patients with sporadic sellar leiomyomas. The first patient is a 25-year-old woman who presented with a 2-year history of amenorrhea and a heterogeneous lesion. The second is a 53-year-old man who presented with headaches and progressive panhypopituitarism, and a large cystic lesion expanding the sella. In both patients, transnasal transphenoidal surgery was performed for resection of the tumor. We review the intraoperative findings, neuropathology and immunohistochemistry and the clinical follow-up. A literature search, which revealed only two prior reported cases of sporadic sellar leiomyomas, and subsequent review led us to conclude that the natural history of sellar leiomyomas relates to the immune status of the patient and that these tumors may cause pituitary dysfunction through infiltration of the gland, mass effect and compression, or even potentially as a byproduct of prolactin secretion intrinsic to the tumor itself. Complete surgical resection of these infiltrating tumors may not be advisable when pituitary function is intact. Long-term endocrine follow-up in these patients is advised. PMID:23219820

Ko, Andrew; Su, David K; Born, Donald; DeSantis, Anthony; Alan Failor, R; Ferreira, Manuel

2012-12-06

336

Male pattern baldness (image)  

MedlinePLUS

Male pattern baldness is a sex-linked characteristic that is passed from mother to child. A man can more accurately predict his chances of developing male pattern baldness by observing his mother's father than by looking ...

337

Anorexia Nervosa in Males  

MedlinePLUS

... Learn / Diversity Issues / Males / Anorexia Nervosa in Males Anorexia Nervosa in Males Anorexia nervosa is a severe, life-threatening disorder in which ... changes to the diagnostic categories and criteria for eating disorders, including the addition of Binge Eating Disorder (BED) ...

338

Thrombosis in Behçet's disease: a Behçet's disease patient with complete thrombotic obstruction of IVC and both iliac veins and decreased protein S activity.  

PubMed

Behçet's disease represents a multisystemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, and uveitis. Although vascular attack and thrombosis are not major complications in Behçet's disease, they can still pose risks that must not be overlooked. In this paper, we reported that a 25-year-old female Behçet's disease patient with complete thrombotic obstruction of the inferior vena cava that was successfully treated by aspiration thrombectomy and balloon angioplasty. The procedure produced marked symptomatic improvement. Currently, data about the treatment and the prophylaxis of thrombotic events in Behçet's disease are lacking. In this case report, we hope to discuss the future direction of such studies, how we understand the mechanism of Behçet's disease hypercoagulability, and which treatments can improve thrombotic tendencies in Behçet's disease. PMID:22200809

Jeong, Harin; Yoo, In-Kyung; Choi, Sungjae; Lee, Youngho; Ji, Jongdae; Song, Gwankyu; Chung, Hwanhoon; Lee, Seunghwa; Jo, Won-Min

2011-12-27

339

Substance abuse patterns and their association with psychopathology and type of hostility in male patients with borderline and antisocial personality disorder  

Microsoft Academic Search

The aim of this study was to investigate the prevalence of substance use disorder in young adult patients with borderline personality disorder (BPD) and antisocial personality disorder (APD) and to ascertain the specific substances each of these groups choose to abuse. An additional aim was to assess whether alcohol and drug abuse in the patients related to their psychopathology and

Pavlos Hatzitaskos; Constantin R Soldatos; Anna Kokkevi; Costas N Stefanis

1999-01-01

340

Myoadenylate deaminase deficiency in a patient with facial and limb girdle myopathy  

Microsoft Academic Search

Absence of AMP-deaminase was demonstrated by histochemical and biochemical methods in a muscle biopsy of a 25-year-old woman with facial and limb girdle myopathy. Venous ammonia failed to rise after ischaemic exercise.

R. Mercelis; J. J. Martin; I. Dehaene; Th. Barsy; G. Berghe

1981-01-01

341

5-alpha-Reductase deficiency causing male pseudohermaphroditism.  

PubMed Central

An infant with male pseudohermaphroditism due to deficiency of 5-alpha-reductase is described, the elder of two affected male siblings. These patients, who come from Pakistan, are the first to be described outside America. Images Fig.

Greene, S A; Symes, E; Brook, C G

1978-01-01

342

Phenotypic variability in male patients carrying the mutant ornithine transcarbamylase (OTC) allele, Arg40His, ranging from a child with an unfavourable prognosis to an asymptomatic older adult.  

PubMed Central

In five different Japanese families, we identified six male hemizygotes (aged 6, 9, 15, 17, 56, and 65 years) and a putative candidate (aged 48 years), carrying a mutant allele of the ornithine transcarbamylase (OTC) gene, a G to A substitution at nucleotide 119 in exon 2 generating histidine in place of arginine. OTC activity in the necropsied liver tissue was reduced to approximately 12% of the control and that of COS 1 cells transfected with Arg40His OTC cDNA was 10.2 +/- 1.8% of the control transfected with wild type OTC cDNA. Clinical features ranged from death during a hyperammonaemic attack (a 9 year old) to a 65 year old asymptomatic man. We consider that the amount of protein ingested by these subjects may be one predisposing factor leading to the manifestation of this disease. Images

Matsuda, I; Matsuura, T; Nishiyori, A; Komaki, S; Hoshide, R; Matsumoto, T; Funakoshi, M; Kiwaki, K; Endo, F; Hata, A; Shimadzu, M; Yoshino, M

1996-01-01

343

Some roots of persistent homosexual fantasy and the quest for father's love: conflicted parental identifications in a male patient: fragment of an analysis.  

PubMed

This is a clinical paper, which includes material from sessions, presenting the process of the analysis of a young adult male whose narcissistic character patterns, related to and evolved from failed attempts to integrate conflicting parental identifications. These unintegrated mother and father identifications contributed to life-long latent homosexual fantasies. Rodney's analysis indicates that for a boy/man, even a mother who has the qualities of a good enough parent, is not good enough to enable him to reach a nonconflicted manhood. A mother cannot provide for the boy the male model he needs and is searching for, the male who would affirm him in his maleness. Rodney wanted a father on whose shoulders he could stand to become a man. Rodney's persistent homosexual fantasy life, his quest for father's love, and his search for a masculine object to identify with stem from a combination of several factors. Rodney's regression to the negative oedipal phase was probably stimulated when father left the family. Rodney was eleven at the time. He felt overwhelmed experiencing himself as the oedipal victor. Unconsciously, Rodney feared his exacerbated incestuous wishes. He projected them upon his mother and subsequently incorporated them in his fantasies. His regression to more infantile dependency feelings was defensive. Rodney's father was an unsuitable object for identification. He was disinterested in Rodney and emotionally unavailable. Rodney, however, sought his father, whose lack of loving acknowledgement resulted in a lack of affirmation of Rodney's masculinity. Mother provided for Rodney the loving acknowledgement he lacked in his relationship with father. She was emotionally sustaining, an energetic, vibrant personality, who was seen by Rodney as a "superior human being." Rodney consciously idealized his mother toward whom he unconsciously also had ambivalent feelings. Rodney's identification with mother was not counterbalanced by the presence of a strong, loving father figure whom he could have used as a suitable model. This led to the development in Rodney of a strong sense of effeminization. Rodney in his homosexual fantasies assumed the so-called "feminine victimized" role. The regression to the negative oedipal phase contributed to an exacerbation of erotic, father-directed feelings, intensified by the identification with mother. Rodney was fixated in his quest for father's love. In addition, Rodney's unconscious guilt related to father and mother directed incestuous impulses, and his intense aggressivesadistic feelings contributed to the masochistic cast of his masturbation fantasies. Rodney's narcissistic aims and the quality of his narcissism changed during the analysis. His grandiosity almost disappeared. Rodney's goals became realistic and he acquired the skills necessary to achieve them. Inhibitions related to the "fear of success" were worked through. This enabled Rodney to compete successfully. His healthy narcissism derives from the success of his many achievements. Though Rodney remained a basically narcissistic personality, he did derive great pleasure from being a giving person. This was one of the many ways in which he identified with his mother. At the present, Rodney's identifications are selective and do not evoke intrapsychic conflict. PMID:9522407

Lax, R F

1997-12-01

344

Growth hormone in male infertility  

PubMed Central

Growth hormone (GH) is expressed in a variety of tissues, including the testes, and has autocrine and paracrine functions as well. This, along with other factors, exerts autocrine and paracrine control over spermatogenesis. GH, used as an adjuvant therapy, induces spermatogenesis in non-responder patients with hypogonadotropic hypogonadism, who are not responding to gonadotropin or pulsatile luteinizing hormone (LH) therapy. GH has an important physiological role to play in spermatogenesis and male fertility.

Magon, Navneet; Singh, Suneeta; Saxena, Ajit; Sahay, Rakesh

2011-01-01

345

Atherosclerosis in male patients with ankylosing spondylitis: the relation with methylenetetrahydrofolate reductase (C677T) gene polymorphism and plasma homocysteine levels.  

PubMed

The aim of this study was to determine the intima-media thickness (IMT) in carotid arteries and to assess the relation of these values with plasma homocysteine (pHcy) levels and methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in patients with Ankylosing spondylitis (AS). Serum lipids, vitamin B12, folic acid, pHcy and acute phase protein levels were measured in all cases. MTHFR C677T gene polymorphisms were determined, and IMT of main carotid artery were evaluated ultrasonographically in all subjects. Bath Ankylosing Spondylitis Disease Activity Index, Ankylosing Spondylitis Disease Activity score and Bath Ankylosing Spondylitis Metrology Index were used to assess disease activity and spinal mobility. Fifty AS patients (mean age of 36.6 ± 4.79 years) and 50 control subjects (36.34 ± 4.72 years) were included in the study. Plasma homocysteine levels of AS patients and control group were also similar (14.26 ± 9.96 vs. 11.81 ± 5.53 ?mol/L). Hyperhomocysteinemia was present in 11 subjects in patient group (22.0 %), while it was seen in 5 subjects in the control group (10.0 %). The MTHFR C677T genotype distribution was as follows: CC 31 (62 %), CT 14 (28 %), TT 5 (10 %) in AS patients. The mean carotid IMT values were also found to be similar between the groups. The most important factor influencing pHcy level was found as MTHFR 677TT genotype. We indicated no difference of atherosclerosis indices revealed by IMT values and pHcy levels AS patients and control subjects. But an association between MTHFR 677 gene polymorphism and pHcy levels was concluded, which may suggest that MTHFR 677 TT polymorphism may be a potential prognostic factor for cardiovascular disease in patients with AS. PMID:23247802

Geçene, Muharrem; Tuncay, Figen; Borman, P?nar; Yücel, Dogan; Senes, Mehmet; Y?lmaz, Behice Kaniye

2012-12-18

346

Male Breast Cancer  

Microsoft Academic Search

Summary Male breast cancer represents with 1.5% of male malignancies a rare disease. Compared to the vast amount of data and knowledge in female breast cancer, male breast cancer is less well-researched and explored. Potential risk factors are oestrogen (exogenous or endogenous), gynaecomastia, radiation, exposure to heat and the Klinefelter’s syndrome. Whereas female breast cancer shows a double-peak risk distribution,

M. Schön; M. Zaiac; P. M. Schlag

1995-01-01

347

Long-term nephrostomy in an adult male spinal cord injury patient who had normal upper urinary tracts but developed bilateral hydronephrosis following penile sheath drainage: pyeloplasty and balloon dilatation of ureteropelvic junction proved futile: a case report  

PubMed Central

Introduction The consequences of spinal cord injury upon urinary bladder are readily recognised by patients and health care professionals, since neuropathic bladder manifests itself as urinary incontinence, or retention of urine. But health care professionals and persons with spinal cord injury may not be conversant with neuropathic dysmotility affecting the ureter and renal pelvis. We report an adult male patient with spinal cord injury, who developed bilateral hydronephrosis after he started managing neuropathic bladder by penile sheath drainage. Case presentation A male patient, born in 1971, sustained spinal cord injury following a motorbike accident in September 1988. In November 1988, intravenous urography showed normal upper tracts. He was advised spontaneous voiding with 2-3 catheterisations a day. In February 1995, this patient developed fever, chills and vomiting. Blood urea: 23.7 mmol/L; creatinine: 334 umol/L. Ultrasound revealed marked hydronephrosis of right kidney and mild hydronephrosis of left kidney. Bilateral nephrostomy was performed in March 1995. Right pyeloplasty was performed in May 1998. In July 2005, this patient developed urine infection and was admitted to a local hospital with fever and rigors. He developed septicaemia and required ventilation. Ultrasound examination of abdomen revealed bilateral hydronephrosis and multiple stones in left kidney. Percutaneous nephrostomy was performed on both sides. Subsequently, extracorporeal shock wave lithotripsy of left renal calculi was carried out. Right nephrostomy tube slipped out in January 2006; percutaneous nephrostomy was performed again. In June 2006, left ureteric antegrade stenting was performed and nephrostomy tube was removed. Currently, right kidney is drained by percutaneous nephrostomy and left kidney is drained by ureteric stent. This patient has indwelling urethral catheter. Conclusion It is possible that regular intermittent catheterisations along with anticholinergic medication right from the time of rehabilitation after this patient sustained paraplegia might have prevented the series of urological complications. Key components to successful management of external drainage of kidney in this patient are: [1] use of size 14 French pigtail catheter for long-term nephrostomy, [2] anchoring the catheter to skin to with Percufix catheter cuff to prevent accidental tug [3], replacing the nephrostomy dressing once a week by the same team in order to provide continuity of care, and [4] changing nephrostomy catheter every six months by a senior radiologist.

2009-01-01

348

Population density influences male–male competition in guppies  

Microsoft Academic Search

This study tested the general prediction that population density affects male–male competition, female mate choice and the opportunity for sexual selection. By manipulating the density of guppies, Poecilia reticulata, while keeping the sex ratio constant, I found that male mating tactics were phenotypically plastic with respect to density. As density increased, males decreased their courtship displays. Male–male competition and mate

Mullica Jirotkul

1999-01-01

349

[Chronic Koro-like Syndrome (KLS) in recurrent depressive disorder as a variant of Cotard's delusion in an italian male patient. A case report and historical review].  

PubMed

Cotard’s syndrome is a delusional syndrome, first described in the 1880ies by Cotard, characterized by a nihilistic delusions about the self and/or the world. In same other cases there is an intense nihilistic belief that the patient’s entire body or parts of it are disintegrated or dead. The syndrome is often associated with severe depression, but are also described neurological cases. Koro was described a little later from Asia and consisted in the belief that one’s own genitalia are shrinking or disappearing and death will ensue thereafter, but there are many cultural variants and the syndrome may present in an incomplete form. We report on a KLS sharing more features with annihilation delusions, such as Cotard’s syndrome. In KLS, the délire de négation may be limited to localized systems or organs. We believe that some complete and incomplete forms of Koro, when embedded in a depressive core, may represent a variant of Cotard’s delusion. In fact, our patient did not reach a complete denial of his entire body, but rather focused on sexual identity. We analysed the psychosexual issues of our case according to Kretschmer’s 1918 view of a “bipolar setting” between sthenic and asthenic characters of a patient suffering from sensitive delusions of (self-) reference. This view may allow us to relate the personological character to the genetic comprehensibility of the delusion. PMID:21779103

Bandinelli, Pier Luca; Trevisi, Manuela; Kotzalidis, Giorgio Demetrio; Manfredi, Giovanni; Rapinesi, Chiara; Ducci, Giuseppe

350

Male Adolescent Contraceptive Utilization.  

ERIC Educational Resources Information Center

The contraceptive utilization of a sample of sexually active, urban, high school males (Black, Hispanic, and White) was examined by anonymous questionnaire. Contraceptive use was haphazard, but White males tended to be more effective contraceptors than the other two groups. Reasons for nonuse were also studied. (Author/SJL)

Finkel, Madelon Lubin; Finkel, David J.

1978-01-01

351

Male butterflies bounce back  

NSDL National Science Digital Library

About five years ago, on the islands of Samoa, most of the male Hypolimnas bolina butterflies, also known as the Eggfly or Blue Moon butterfly, disappeared. Now, scientists report that the males have made a comeback and are almost as common as females.

American Association for the Advancement of Science (AAAS;)

2007-07-12

352

Black Male Rising  

ERIC Educational Resources Information Center

The author reports on Ohio's bevy of education initiatives that take aim at helping African-American male students succeed. The Todd Anthony Bell National Resource Center for the African American Male at The Ohio State University is one of several initiatives that help African-American men succeed in Ohio. All the programs focus on individual…

Feintuch, Howard

2010-01-01

353

Black Male Rising  

ERIC Educational Resources Information Center

|The author reports on Ohio's bevy of education initiatives that take aim at helping African-American male students succeed. The Todd Anthony Bell National Resource Center for the African American Male at The Ohio State University is one of several initiatives that help African-American men succeed in Ohio. All the programs focus on individual…

Feintuch, Howard

2010-01-01

354

Gay Male Aging  

Microsoft Academic Search

A review of empirically-based publications on gay male gerontology was conducted. A total of 58 articles is presented. Findings indicate that the long-held negative stereotypes of gay male elders are unwarranted and have been repeatedly debunked. Happiness and successful adaptation to old age are possible and are frequently reported by older gay men. Substantial and unique competencies in old age

Jim Wahler; Sarah G. Gabbay

1997-01-01

355

MALE TEACHERS AND THE \\  

Microsoft Academic Search

In this paper, we interrogate the call for more male role models within the context of boys' education debates in Australia and North America. We explicate links between failing masculinities and this call for more male teachers, arguing that the debate is driven by a \\

WAYNE MARTINO; MICHAEL KEHLER

356

Male contraceptive technology for nonhuman male mammals.  

PubMed

Contraceptive techniques applied to males have potential to mitigate diverse instances of overpopulation in human and animal populations. Different situations involving different species dictate that there is no ideal male contraceptive, and emphasizes the value of varying approaches to reducing male fertility. A majority of work in this field has focused on non-surgically destroying the testes or obstructing the epididymis, and suppressing gonadotropin secretion or inducing immune responses to reproductive hormones or sperm-specific antigens. Injection of tissue-destructive agents into the testes or epididymides can be very effective, but often is associated with unacceptable inflammatory responses and sometimes pain. Hormonal vaccines are often not efficacious and provide only short-term contraception, although GnRH vaccines may be an exception to this generality. Finally, there are no clearly effective contraceptive vaccines based on sperm antigens. Although several techniques have been developed to the point of commercialization, none has yet been widely deployed other than surgical castration. PMID:18191924

Bowen, R A

2007-11-26

357

Interaction and efficacy of Keigai-rengyo-to extract and acupuncture in male patients with acne vulgaris: A study protocol for a randomized controlled pilot trial  

Microsoft Academic Search

Background  In consideration of patients seeking to use traditional Chinese medicine, an evidence-based potentiality for safe and effective\\u000a use of herbal medicine and acupuncture in treatment of acne vulgaris has been suggested. However, despite common use of a\\u000a combination of herbal medicine and acupuncture in clinical practice, the current level of evidence is insufficient to draw\\u000a a conclusion for an interaction

Kyu Seok Kim; Yoon-Bum Kim

2011-01-01

358

Smaller right amygdala in Caucasian alcohol-dependent male patients with a history of intimate partner violence: a volumetric imaging study.  

PubMed

Studies have shown that various brain structure abnormalities are associated with chronic alcohol abuse and impulsive aggression. However, few imaging studies have focused on violent individuals with a diagnosis of alcohol dependence. The present study used volumetric magnetic resonance imaging (MRI) to compare the volumes of different structural components of prefrontal cortex and six subcortical structures in perpetrators of intimate partner violence with alcohol dependence (IPV-ADs), non-violent alcohol-dependent patients (non-violent ADs) and healthy controls (HCs). Caucasian men (n?=?54), ages 24-55, who had participated in National Institutes of Alcohol Abuse and Alcoholism treatment programs, were grouped together as IPV-ADs (n?=?27), non-violent ADs (n?=?14) and HCs (n?=?13). The MRI scan was performed at least 3 weeks from the participant's last alcohol use. T1-weighted images were used to measure the volumes of intracranial space, gray and white matter, orbitofrontal cortex, medial prefrontal cortex, lateral prefrontal cortex, and six subcortical structures. Results revealed that IPV-ADs, compared with non-violent ADs and HCs, had a significant volume reduction in the right amygdala. No significant volumetric difference was found in other structures. This finding suggests that structural deficits in the right amygdala may underlie impulsive types of aggression often seen in alcohol-dependent patients with a history of IPV. It adds to a growing literature suggesting that there are fundamental differences between alcohol-dependent patients with and without IPV. PMID:21995346

Zhang, Lishu; Kerich, Mike; Schwandt, Melanie L; Rawlings, Robert R; McKellar, Joshua D; Momenan, Reza; Hommer, Daniel W; George, David T

2011-10-13

359

Serum Cystatin C is a Potential Endogenous Marker for the Estimation of Renal Function in Male Gout Patients with Renal Impairment  

PubMed Central

Serum creatinine level is the most commonly used indices for assessment of glomerular filtration rate (GFR), even though these indices have been shown to have some limitations in clinical practice. We investigated the diagnostic efficacy of serum cystatin C compared to that of serum creatinine levels and identified the relating factors associated with changes in serum cystatin C levels in gout patients with renal impairment. A total of 68 gouty patients with renal impairment were enrolled in this study. Diagnostic efficacy of serum cystatin C levels was evaluated through non-parametric receiver operating characteristic (ROC) analysis. The risk factors for changes in serum cystatin C levels were confirmed using multivariate regression analysis. With 24-hr urine creatinine clearance (Ccr) as the reference for GFR, 1/cystatin C (r=0.702, P<0.001) showed a significantly higher correlation with Ccr than 1/creatinine (r=0.665, P<0.001). Multivariate correlation analysis demonstrated that the clinical parameters for increased serum cystatin C are a higher stage of chronic kidney disease, older age, use of allopurinol, and lower high density lipoprotein-cholesterol. The area under the curve (AUC) at ROC plots identified that of serum cystatin C was significantly greater than that of serum creatinine (AUC 0.804 of cystatin C and AUC 0.745 of creatinine). The study suggests that serum cystatin C is a reliable endogenous marker for the assessment of renal function or GFR in gout patients with renal impairment.

Choe, Jung-Yoon; Park, Sung-Hoon

2010-01-01

360

Male Genitoplasty for Intersex Disorders  

PubMed Central

Aim. To evaluate surgical procedures adopted for male genitoplasty in intersex disorders. Patients and Methods. Case records of intersex patients undergoing male genitoplasty from Pediatric Intersex clinic were studied. Results. Of 356 intersex cases undergoing urethroplasty from 1989–2007, the hypospadias was penoscrotal (68%), scrotal (17%) and perineal (15%). 351 patients underwent chordee correction for mild: moderate: severe chordee in 24 : 136 : 191 cases. Byars flaps were fixed upto the corona in 267 cases. Urethroplasty performed was Theirsch duplay in 335 cases, Snodgrass in 16 cases and Ducketts onlay graft in 5 cases that did not require chordee correction. Age at urethroplasty was 2.5 years—22 years (mean 11.5 years, median—5.6 years). Penoscrotal transposition correction and testicular prosthesis insertion were performed independently. Complications included fistula (45), recurrent fistula (11), stricture (12), baggy urethra (8) and recurrent infection due to persistent vaginal pouch (5). Additional distal urethroplasty was required in 15 patients for previous urethroplasty done upto the corona 5–15 years earlier. Conclusion. Hypospadias in intersex disorders is associated with severe chordee in most cases and requires an early chordee correction to allow phallic growth, staged urethroplasty and multiple surgeries to achieve good cosmetic and functional results.

Sharma, Shilpa; K. Gupta, Devendra

2008-01-01

361

Cross-sectional relationships of exercise and age to adiposity in60,617 male runners  

SciTech Connect

The objective of this report is to assess in men whether exercise affects the estimated age-related increase in adiposity, and contrariwise, whether age affects the estimated exercise-related decrease in adiposity. Cross-sectional analyses of 64,911 male runners who provided data on their body mass index (97.6 percent), waist (91.1 percent), hip (47.1 percent), and chest circumferences (77.9 percent). Between 18 to 55 years old, the decline in BMI with weekly distance run (slope+-SE) was significantly greater in men 25-55 years old (slope+-:-0.036+-0.001 kg/m2 per km/wk) than in younger men (-0.020+-0.002 kg/m 2 per km/wk). Declines in waist circumference with running distance were also significantly greater in older than younger men (P<10-9 for trend),i.e., the slopes decreased progressively from -0.035+-0.004 cm per km/wk in 18-25 year old men to -0.097+-0.003 cm per km/wk in 50-55 year old men. Increases in BMI with age were greater for men who ran under 16km/wk than for longer distance runners. Waist circumference increased with age at all running levels, but the increase appeared to diminish by running further (0.259+-0.015 cm per year if running<8 km/wk and 0.154+-0.003 cm per year for>16 km/wk). In men over 50 years old, BMI declined -0.038+-0.001 kg/m2 per km/wk run when adjusted for age and declined -0.054+-0.003 kg/m2 (increased 0.021+-0.007 cm) per year of age when adjusted for running distance. Their waist circumference declined-0.096+-0.002 cm per km/wk run when adjusted for age and increased 0.021+-0.007 cm per year of age when adjusted for running distance. These cross-sectional data suggest that age and vigorous exercise interact with each other in affecting mens adiposity, and support the proposition that vigorous physical activity must increase with age to prevent middle-age weight gain. We estimate that a man who ran 16 km/wk at age 25 would need to increase their weekly running distance by 65.7 km/wk by age 50 in order to maintain his same waist circumference.

Williams, Paul T.; Pate, Russell R.

2004-06-01

362

[Male sexual dysfunction and obesity].  

PubMed

Obesity concerns more than 200 million people in the world, with an increasing prevalence in western countries. It is closely related to multiple medical conditions, such as diabetes and hypertension. It was recently shown that testosterone deficiency syndrome and erectile dysfunction (ED) are also linked to male obesity. In this group of patients, ED may be due to defects in corpus cavernosum relaxation, endocrine modifications and nerve signal alterations. Weight loss and increased physical activities can improve erectile function in 30% of obese patients. Additional medical treatments of ED enhance erectile function in more than 80% of patients. Self image improvement associated with appropriate erectile dysfunction medical treatment allow better sexual life and potentially increased motivation for weight loss. PMID:23330231

Lucca, Ilaria; Paduch, Darius A; Pralong, François; Vaucher, Laurent

2012-12-01

363

Beh?et's disease presenting as new onset of confusion in a male patient of North African origin in the UK  

PubMed Central

A 50-year-old right-handed man presented with headache accompanied by new onset confusion and slurring of speech over a 5-day period. This was initially suspected to be due to a transient ischaemic attack. On examination he had a clear ptosis of his left eye, which had developed just 6 days prior to his most recent admission; however, the rest of his neurological examination was normal. A neuropsychiatric review showed poor verbal recall, below average visual contrast ability and below average verbal learning scores. He had a medical history of recurrent oral ulcerations accompanied by anterior uveitus and recurrent genital ulcerations on the scrotum. Imaging showed increased unilateral signal in the left thalamic area, which when taken together with the clinical history, supports the internationally recognised diagnostic criteria for Behçet's disease. The patient lacked insight into his condition meaning that long-term residential care may be required.

Dolan, Ross; Watson, Suzanne; Bathgate, Debbie

2010-01-01

364

Males and Eating Disorders  

MedlinePLUS

... Bar Home Current Issue Past Issues Males and Eating Disorders Past Issues / Spring 2008 Table of Contents For ... this page please turn Javascript on. Photo: PhotoDisc Eating disorders primarily affect girls and women, but boys and ...

365

Interaction and efficacy of Keigai-rengyo-to extract and acupuncture in male patients with acne vulgaris: A study protocol for a randomized controlled pilot trial  

PubMed Central

Background In consideration of patients seeking to use traditional Chinese medicine, an evidence-based potentiality for safe and effective use of herbal medicine and acupuncture in treatment of acne vulgaris has been suggested. However, despite common use of a combination of herbal medicine and acupuncture in clinical practice, the current level of evidence is insufficient to draw a conclusion for an interaction and efficacy of herbal medicine and acupuncture. Therefore, considering these methodological flaws, this study was designed to assess the interaction and efficacy of an available herbal medicine, Keigai-rengyo-to extract (KRTE), and acupuncture for treatment of acne using the 2 × 2 factorial design and the feasibility of a large clinical trial. Methods/Design A randomized, assessor single blinded, 2 × 2 factorial pilot trial will be conducted. Forty four participants with acne vulgaris will be randomized into one of four groups: waiting list group (WL), KRTE only group (KO), acupuncture only group (AO), and KRTE and acupuncture combined treatment group (KA). After randomization, a total of 8 sessions of acupuncture treatment will be performed twice a week in the AO- and KA groups, respectively. Patients in the KO- and KA groups will be prescribed KRTE 3 times a day at a dose of 7.4 g after meals for 4 weeks. The following outcome measurements will be used in examination of subjects: the mean percentage change and the count change of inflammatory and non-inflammatory acne lesions, the Skindex 29, visual analogue scale (VAS) and investigator global assessment (IGA) from baseline to the end of the trial. Trial Registration The trial is registered with the Clinical Research Information Service (CRiS), Republic of Korea: KCT0000071.

2011-01-01

366

Cultivating male allies  

Microsoft Academic Search

Females make large investments in their children and compete among themselves to establish and maintain privileged relationships\\u000a with male allies who demonstrate both an ability and a willingness to provide fitness-enhancing advantages. Various “strategies”\\u000a and their more numerous, associated “tactics” are utilized in the competition. Alleged strategies include using sexuality,\\u000a producing offspring, assisting the male in his own intrasexual contests,

Bonnie Lori Hooks; Penny Anthon Green

1993-01-01

367

Polymorphisms and Male Infertility  

Microsoft Academic Search

The analysis of polymorphisms in genes involved in spermatogenesis represents one of the most exciting areas of research in\\u000a the genetics of male infertility. These studies are not only important for identifying genetic risk factors for male infertility,\\u000a but they may also represent an important starting point for searching for genes involved in spermatogenesis through linkage\\u000a analysis. Despite many efforts,

Csilla Krausz

368

The male presence  

Microsoft Academic Search

Male domination of the news media begins, very simply, with numerical superiority. The male presence in the news industry is immense and far?reaching. Ninety?four percent of top management positions in U.S. news media are occupied by men. The top five executives at Capital Cities, ABC, Times Mirror, CBS, Knight?Ridder, the New York Times, and Turner Broadcasting System are all men.

David Croteau; William Hoynes

1993-01-01

369

SRY-negative 46,XX male with normal genitals, complete masculinization and infertility  

Microsoft Academic Search

XX maleness is a rare syndrome with a frequency of 1 in 20 000-25 000 males. XX males exist in different clinical categories with ambiguous genitalia or partially to fully mature male genitalia, in combination with complete or incomplete masculinization. In this study, we report a case of SRY-negative XX male with complete masculinization but infertility. The patient had fully

Singh Rajender; Vutukuri Rajani; Nalini J. Gupta; Baidyanath Chakravarty; Lalji Singh; Kumarasamy Thangaraj

2006-01-01

370

Pathologies of the male breast.  

PubMed

The majority of breast lesions in men are benign. Gynaecomastia is a very common condition in which hormonal changes cause male breasts to enlarge. Three radiological patterns of gynaecomastia have been described: nodular, dendritic, and diffuse glandular pattern. The main differential diagnosis is lipomastia, which is when adipose tissue deposits are found in the subcutaneous tissue. Male breast cancer is rare. The main risk factors are pathologies that cause hormonal imbalances, a history of chest irradiation, and a family history of breast cancer (particularly in families carrying a mutation of the gene BRCA2). Mammography usually shows a mass with no calcifications. Sonography is useful to investigate local disease spread, and for detecting any enlarged axillary lymph nodes. MRI is not currently indicated to investigate male breast cancer. Very often, the clinical examination alone is enough to distinguish benign lesions from malignant lesions. Imaging must not be automatically carried out, but rather it should be used when the diagnosis is clinically uncertain or when patients present risk factors for breast cancer, as well as for guiding biopsies and for assessing disease spread. PMID:23218476

Charlot, M; Béatrix, O; Chateau, F; Dubuisson, J; Golfier, F; Valette, P J; Réty, F

2012-12-05

371

Sperm DNA damage in male infertility: etiologies, assays, and outcomes  

Microsoft Academic Search

Male factor infertility is the sole cause of infertility in approximately 20% of infertile couples, with an additional 30%\\u000a to 40% secondary to both male and female factors. Current means of evaluation of male factor infertility remains routine semen\\u000a analysis including seminal volume, pH, sperm concentration, motility, and morphology. However, approximately 15% of patients\\u000a with male factor infertility have a

Ryan T. Schulte; Dana A. Ohl; Mark Sigman; Gary D. Smith

2010-01-01

372

Melioidosis in an adult male.  

PubMed

Infection with Burkholderia pseudomallei has been described, albeit rarely, patients in Bangladesh. Infection usually follows percutaneous inoculation or inhalation of the causative bacterium, which is present in soil and surface water in the endemic region. A 35-year-young male farmer presented with prolonged fever and significant weight loss. Patient gradually deteriorated despite getting different antibiotics including intravenous ceftriaxone and metronidazole. Panels of investigations were done which revealed no diagnostic confirmation except uncontrolled diabetes and multiple abscesses in different organs. Melioidosis was suspected and serum samples were positive for Burkholderia pseudomallei antibody. The case illustrates the importance of non-specific nature of the clinical presentation and high index of suspicion of uncommon diseases like melioidosis where the disease has not been considered as an endemic. PMID:23715373

Majumder, M I; Haque, M M; Ahmed, M W; Alam, M N; Rahman, M W; Akter, F; Basher, A; Maude, R J; Faiz, M A

2013-04-01

373

[Testosterone deficit syndrome in the old male].  

PubMed

Epidemiological studies have demonstrated that prevalence of hypogonadism in old males increases with every additional decade of life. These males present various symptoms including decrease of sexual function, decrease of cognitive function, altered lipid profile, increased visceral adiposity, changes in bone density and muscular strength secondary to atrophy. Currently, testosterone injections and gel preparations are the most used. Testosterone replacement therapy provides significant symptomatic improvements for men with late start hypogonadism. Long-term benefits and risks of testosterone replacement therapy will be more evident when testosterone effects are studied on all health related parameters over a prolonged period of time. There is a large ongoing multicentric randomized clinical trial sponsored by NIH for testosterone control in old men with low testosterone levels. Its results may give answers to the possible benefits and risks of testosterone replacement in aging males. If an aging male is diagnosed as late-start hypogonadism, the urologist should discuss with the patient potential benefits and risks of testosterone therapy. Aging males with significant erythrocytosis, untreated sleep apnea, prostate cancer and high risk of cardiovascular events must be excluded from testosterone replacement therapy. Currently, there are not enough evidences to clearly state that the benefits of testosterone replacement therapy in aging males are better than the risks of this treatment. A general recommendation cannot be given that testosterone replacement therapy may be applied to all aging males with low testosterone levels independently of significant signs or symptoms. PMID:24047627

Chantada Abal, Venancio; Vazquez-Martul, Dario; Portela Pereira, Paula; Aller Rodriguez, Marcos; Barreiro Mallo, Aarona; Sanchez Vazquez, Andrea

2013-09-01

374

Male Registered Nurses, 1995  

Microsoft Academic Search

Men constitute a small minority of registered nurses (RNs) in Canada, but their numbers have risen sharply in the last decade. In 1995, almost 4% of RNs were men, up from just over 2% in 1985. The pr oportion of male nurses is particu- larly high in Quebec, where the 1995 figure was 8%. Some areas of nursing are more

Richard Trudeau

1996-01-01

375

The Gay Male Gaze  

Microsoft Academic Search

This article examines body image disturbance among gay men from various sociocultural perspectives. A review of the empirical literature on body image disturbance indicates that gay males experience greater body dissatisfaction than other groups due to their higher levels of gender nonconformity. The impact of gendered power relations on body image is considered in light of feminist, postmodernist, queer, and

Mitchell J. Wood

2004-01-01

376

The ageing male  

Microsoft Academic Search

. With prolonged life expectancy, men and women can expect to live one-third of their lives with some form of hormone deficiency. The ageing male, in particular, has the added problem of developing urological diseases, such as benign prostatic hyperplasia (BPH), prostate cancer, continence disorders and erectile dysfunction. When discussing age-related problems, it is often difficult to separate and to

C. Schulman; B. Lunenfeld

2002-01-01

377

Empowering Young Black Males  

ERIC Educational Resources Information Center

|Of all the challenges we face in education today, the author can think of none greater than the challenge of motivating, educating, and empowering black male learners. The fact that this group of students is in crisis is evident on multiple levels, starting with graduation rates. According to the Schott Foundation (2008), the U.S. high school…

Kafele, Baruti K.

2012-01-01

378

Male mating biology  

PubMed Central

Before sterile mass-reared mosquitoes are released in an attempt to control local populations, many facets of male mating biology need to be elucidated. Large knowledge gaps exist in how both sexes meet in space and time, the correlation of male size and mating success and in which arenas matings are successful. Previous failures in mosquito sterile insect technique (SIT) projects have been linked to poor knowledge of local mating behaviours or the selection of deleterious phenotypes during colonisation and long-term mass rearing. Careful selection of mating characteristics must be combined with intensive field trials to ensure phenotypic characters are not antagonistic to longevity, dispersal, or mating behaviours in released males. Success has been achieved, even when colonised vectors were less competitive, due in part to extensive field trials to ensure mating compatibility and effective dispersal. The study of male mating biology in other dipterans has improved the success of operational SIT programmes. Contributing factors include inter-sexual selection, pheromone based attraction, the ability to detect alterations in local mating behaviours, and the effects of long-term colonisation on mating competitiveness. Although great strides have been made in other SIT programmes, this knowledge may not be germane to anophelines, and this has led to a recent increase in research in this area.

Howell, Paul I; Knols, Bart GJ

2009-01-01

379

Gender Role Socialization and Male-on-Male vs. Female-on-Male Child Sexual Abuse  

Microsoft Academic Search

Most images of sexual abuse in contemporarysociety involve adult male perpetrators and femalevictims. In this paper, we consider the effects of childsexual abuse on the adult male gender roles of boyhood survivors of abuse. Specifically, we examinethe effects of coerced male-on-male (CM), coercedfemale-on-male (CF), and non-coerced female-on-male (NF)sexual contact on attitudes toward and behavior in adult heterosexual relationships. Usinglongitudinal data

Lauren E. Duncan; Linda M. Williams

1998-01-01

380

Increased dopamine level enhances male-male courtship in Drosophila.  

PubMed

Sexual behavior between males is observed in many species, but the biological factors involved are poorly known. In mammals, manipulation of dopamine has revealed the role of this neuromodulator on male sexual behavior. We used genetic and pharmacological approaches to manipulate the dopamine level in dopaminergic cells in Drosophila and investigated the consequence of this manipulation on male-male courtship behavior. Males with increased dopamine level showed enhanced propensity to court other males but did not change their courtship toward virgin females, general olfactory response, general gustatory response, or locomotor activity. Our results indicate that the high intensity of male-male interaction shown by these manipulated males was related to their altered sensory perception of other males. PMID:18495888

Liu, Tong; Dartevelle, Laurence; Yuan, Chunyan; Wei, Hongping; Wang, Ying; Ferveur, Jean-François; Guo, Aike

2008-05-21

381

Radiographic outcome of surgical treatment of adolescent idiopathic scoliosis in males versus females  

Microsoft Academic Search

BACKGROUND: Studies on adolescent idiopathic scoliosis have well documented the differences between natural history of male and female patients. There are also differences in responses to nonoperative treatment, but the results of operative treatment in male patients compared with females have not been widely reported. Only few studies had compared the outcomes of operative treatment between male and female patients

Ebrahim Ameri; Hamid Behtash; Bahram Mobini; Farzad Omidi-Kashani; Behnam Momeni

2008-01-01

382

Male Breast Cancer  

Microsoft Academic Search

\\u000a The aim of studying the epidemiology of breast cancer is to identify risk factors that could be eliminated or inhibited. Unfortunately,\\u000a the two major risk factors are gender and increasing age, neither of which can be avoided. Nevertheless, the relative rarity\\u000a of male breast cancer (MBC) has prompted investigations in the hope that the disease in men can give clues

Ian S. Fentiman

383

Male genital modification  

Microsoft Academic Search

By modifying the body in meaningful ways, human beings establish their identity and social status. Lip plugs, ear plugs, penis\\u000a sheaths, cosmetics, ornaments, scarification, body piercings, and genital modifications encode and transmit messages about\\u000a age, sex, social status, health, and attractiveness from one individual to another. Through sociocultural sexual selection,\\u000a male genital modification plays an important role as a sociosexual

Raven Rowanchilde

1996-01-01

384

Superior labrum anterior-to-posterior tear.  

PubMed

The patient was a 25-year-old male college student with a chief complaint of right shoulder pain. The patient was initially diagnosed with bicipital tendinitis by his physician and had been treated for 4 weeks by a physical therapist. However, his symptoms did not improve and he was unable to return to his preinjury activity levels, so he sought the services of another physical therapist for a second opinion. Due to concern for a labrum tear, the physical therapist referred the patient to an orthopaedic surgeon. Magnetic resonance arthrography revealed findings consistent with a superior labrum anterior-to-posterior tear. PMID:23202247

Sum, Jonathan C; Omid, Reza

2012-11-30

385

[Epidemiology and etiology of male urinary incontinence].  

PubMed

Compared to female urinary incontinence, the prevalence and socioeconomic impact of male urinary incontinence has not gained much attention from epidemiologists. Moreover, the few available epidemiological surveys vary in their use of definitions and methodology, which are known to have great impact on the resulting prevalences. Therefore, the interpretation of the findings is difficult. Depending on definitions and methods, the prevalence of male urinary incontinence ranges between 5.4 and 15%. Urgency incontinence is the predominant subtype in all age groups, although the relative proportion shifts towards stress incontinence with rising age. Neurological and posttraumatic causes for male stress incontinence become less important as the frequency of iatrogenic interventions (radiation, prostate surgery) increase. Additional risk factors for male urinary incontinence are age, immobility, and neurological diseases. Surgery of the prostate (TURP, radical prostatectomy) is especially associated with postoperative urinary incontinence if bladder and/or sphincter dysfunctions are preexisting, if the patient is particularly old, and the surgeon's experience is limited. The etiology of male urgency incontinence comprises detrusor instability caused by obstruction, age-related detrusor degeneration, insufficient inhibitory CNS control over afferent detrusor overstimulation, and neurological diseases. The pathophysiological key factors of male continence are functional urethral length and maximum closure pressure, the preservation of which should receive the unrestricted attention of every prostate surgeon. PMID:20376650

Hampel, C; Thüroff, J W; Gillitzer, R

2010-04-01

386

Clomiphene for the treatment of male infertility.  

PubMed

Male infertility is a relatively common condition caused by low sperm production, immobile sperm, or blockages that prevent the delivery of sperm. This condition can be caused by a variety of illnesses, injuries, chronic health problems, lifestyle choices, other factors, or idiopathic, in which abnormal semen parameters occur without an identifiable cause. Medical management traditionally focuses on correcting endocrine abnormalities related to hormone deficiencies. Clomiphene citrate is an antiestrogen thought to increase sperm parameters in males attempting to conceive. The objective of this review was to evaluate the efficacy and safety of clomiphene citrate in the treatment of male patients with infertility. A literature search of MEDLINE (1966-June 2012) and EMBASE (1980-June 2012) was conducted using the medical terms clomiphene and male infertility and 9 clinical studies were identified. Overall, only 1 study detected a statistically significant benefit on the pregnancy rate in the clomiphene group; however, the majority of the studies demonstrated a statistically significant increase in sperm concentrations. At doses used to treat male infertility, clomiphene was well tolerated with no identified serious adverse effects. Based on the reviewed studies there is insufficient evidence to indicate that clomiphene is effective for the treatment of male infertility. PMID:23202725

Willets, Amy E; Corbo, Jason M; Brown, Jamie N

2012-11-30

387

Sex Education and Rehabilitation With Schizophrenic Male Outpatients  

Microsoft Academic Search

Research indicates that schizophrenic patients lack intimate relationships and show a high rate of sexual dysfunction. Despite increasing awareness of the rights of handicapped persons to sexual expression, the treatment of schizophrenic patients rarely addresses their sexuality. A sex education program for recent-onset male schizophrenic patients attending an outpatient clinic was developed in response to several incidents involving patients’ inappropriate

David Lukoff; Debbie Gioia-Hasick; Greer Sullivan; Joshua S. Golden

1986-01-01

388

Developments in male contraception.  

PubMed

Relevant research efforts in male contraception involve: 1) hormonal approaches to block sperm production by inhibiting the hypothalamic-pituitary-gonadal axis, 2) disruption of sperm production by drugs that act directly on the testes, 3) interruption of sperm transport, and 4) alteration of secretions of the accessory sex glands and their subsequent effect on the spermatozoa. Both agonistic and antagonistic synthetic analogs of the hypothalamic gonadotropin releasing hormone (GnRH) factor cost too much and lack an effective mode of administration. Recent studies indicate that over 90% of Chinese and Indonesian men can develop complete azoospermia following either a testosterone or a progestin and an androgen combination treatment. Vaccines that utilize GnRH and follicle stimulating hormone as the active antigens have been introduced in clinical studies in the US and India. Drugs such as sulfasalazine, pyrimethamine, nitrofurane, and bis(di-chloracytal) diamines reduce male fertility but side effects make them unacceptable. Dinitropyrroles, halopropanedils, chlorosugars, and indazole carboxylic acids have been tried in laboratory animals. Gossypol rendered men infertile in large-scale clinical studies conducted in China but synthesis of safer analogs has not succeeded. Extracts of another plant, tripterigium wilfordii, are used in China as a popular herbal medicine. Vasectomy has improved with no-scalpel vasectomy and by the novel technique of blocking the vas with cured in situ polymeric plugs. Preliminary data suggest that men prefer condoms made from polyurethane as opposed to latex rubber increasingly used to protect against AIDs and sexually transmitted diseases. The antifungal agents, imidazoles, have spermicidal activity and synthetic variants may reduce undesirable side effects. Research on male-oriented methods has intensified during the last 10-15 years, but a new product is not likely to appear in the next 5-10 years. PMID:12286189

Bialy, G; Alexander, N J

1992-01-01

389

Interactions in male baboons: the importance of both males’ testosterone  

Microsoft Academic Search

To date, research on testosterone and behavior has focused on individuals, even when studying social behaviors that necessarily\\u000a involve multiple participants. Here, we explore male responses to other males of different dominance ranks and testosterone\\u000a levels in a population of wild baboons. In chacma baboons (Papio hamadryas ursinus) of the Okavango Delta, a male’s testosterone is related to his rank

T. J. Bergman; J. C. Beehner; D. L. Cheney; R. M. Seyfarth; P. L. Whitten

2006-01-01

390

Need for Physician Education on the Benefits and Risks of Male Circumcision in the United States  

ERIC Educational Resources Information Center

|Physicians may be called upon to counsel male patients or parents of newborn males regarding their decision to circumcise their newborn sons. The purpose of the present study was to describe physicians who do not understand the benefits and risks associated with male circumcision well enough to counsel parents of newborn male infants and adult…

Carbery, Baevin; Zhu, Julia; Gust, Deborah A.; Chen, Robert T.; Kretsinger, Katrina; Kilmarx, Peter H.

2012-01-01

391

The ageing male.  

PubMed

With prolonged life expectancy, men and women can expect to live one-third of their lives with some form of hormone deficiency. The ageing male, in particular, has the added problem of developing urological diseases, such as benign prostatic hyperplasia (BPH), prostate cancer, continence disorders and erectile dysfunction. When discussing age-related problems, it is often difficult to separate and to distinguish between the natural ageing process, ageing amplifiers and an acute or chronic illness, or inter-current diseases. Partial endocrine deficiencies of ageing are associated with a decrease in the peripheral levels of testosterone, dehydroepiandrosterone (DHEA), DHEA sulphate (DHEA-S), growth hormone, insulin-like growth factor and melatonin. There is also a concomitant increase in luteinising hormone and follicle stimulating hormone. The concentration of free biologically active testosterone is lowered further by an increase in sex hormone binding globulin (SHBG). Hormonal changes in the ageing male are associated with changes in the body mass index, osteoporosis, sleep and mood disorders. A number of testosterone replacement therapies are available. These therapies should maintain physiological levels not only of serum testosterone, but also of its metabolites, including dihydrotestosterone (DHT) and estradiol. Men on testosterone therapy should be monitored at 3-month intervals during the first year of use and, thereafter, at 1-year intervals if they are stable. The association of testosterone replacement with development of prostate cancer has not been determined. PMID:12088188

Schulman, C; Lunenfeld, B

2002-05-01

392

Invasive Mucormycosis in a Patient With Liver Cirrhosis: Case Report and Review of the Literature  

PubMed Central

Introduction Cutaneous Mucormycosis is a rare opportunistic infection caused by Zygomycetes class of fungi that is often fatal, requiring aggressive local control as well as systemic therapy. Few cases of mucormycosis were described in patients with liver cirrhosis, mostly rhino-orbital. To our knowledge, only two cases of upper extremity involvement was reported in cirrhosis while a few cases were reported in the post-transplant setting. We report herein the third case of upper extremity mucor infection in the setting of liver cirrhosis. Case Presentation We described a rare case of forearm infection originating in a traumatic intravenous access portal in a 25 year-old woman with liver cirrhosis secondary to autoimmune hepatitis. Discussion She developed acute on chronic liver failure during the last trimester of pregnancy, which was terminated. Painful, erythematous lesion was noted on her right forearm in the area of intravenous access, which later became necrotic. Extensive debridement was done and histopathological examination confirmed the diagnosis of mucormycosis. The patient started on Amphotericin B. Her condition continued to deteriorate and ended up with above elbow amputation followed by right shoulder disarticulation. She died two days later due to multi-organ failure. In conclusion, forearm mucromycosis in liver cirrhosis can be fatal.

Elsiesy, Hussien; Saad, Mohamed; Shorman, Mahmoud; Amr, Samir; Abaalkhail, Faisal; Hashim, Almoutaz; Al Hamoudi, Waleed; Al Sebayel, Mohamed; Selim, Khalid

2013-01-01

393

Double-blind, Controlled, Clinical Trial Planned in Germany to Investigate the Efficacy of Psychotherapy Combined with Triptorelin in Adult Male Patients with Severe Pedophilic Disorders: Presentation of the Study Protocol.  

PubMed

Background: The treatment of paraphilias, especially of pedophilia, centers upon cognitive-behavioral psychotherapy and pharmacologic interventions. Two open, uncontrolled clinical studies using the synthetic LHRH-agonist triptorelin suggested that, combined with psychotherapy, antiandrogen treatment reduced deviant sexual fantasies, urges, and behaviors in paraphilic patients. There is a need for further research using controlled, randomized trials to examine the effectiveness of sexual offender treatment including psychotherapeutic and pharmacologic interventions. Objective: The aim of this pilot study is to evaluate the efficacy and tolerability of cognitive-behavioral psychotherapy together with intramuscular (IM) 3-monthly injections of triptorelin in adult men with severe pedophilia. Study design and methods: In this multicenter, forensic psychiatric hospital-based, double-blind, controlled, parallel group phase IV trial conducted in Germany, convicted male sexual offenders aged ? 18 years with pedophilia, as defined by DSM-IV-TR criteria, will be randomized to receive study-specific psychotherapy together either with triptorelin or placebo for 12 months (total of 4 injections). This is a pilot study, therefore exploratory data analyses will be carried out of three different target parameters: 1. Changes in psychosexual characteristics using the Multiphasic Sex Inventory (scale: sexual abuse of children) 2. Changes in the risk of violent sexual behavior using the Sexual Violence Risk-20 total score 3. Changes in serum testosterone concentration Treatment effects will be assessed by comparing baseline values with those at the final examination (month 12). Limitations: The absence of real-life stimulants to test for actual recidivism limits possible findings. The study will be conducted in agreement with the European GCP-guideline, all relevant legal requirements, and the legal framework for voluntary treatment of convicted sexual offenders in Germany. PMID:23585468

Briken, Peer; Berner, Wolfgang

2012-01-01

394

Male-male pheromone signalling in a lekking Drosophila  

PubMed Central

Interest in sex pheromones has mainly been focused on mate finding, while relatively little attention has been given to the role of sex pheromones in mate choice and almost none to competition over mates. Here, we study male response to male pheromones in the lekking Drosophila grimshawi, where males deposit long-lasting pheromone streaks that attract males and females to the leks and influence mate assessment. We used two stocks of flies and both stocks adjusted their pheromone depositing behaviour in response to experimental manipulation, strongly indicating male ability to distinguish between competitors from qualitative differences in pheromone streaks alone. This is the first example of an insect distinguishing between individual odour signatures. Pheromone signalling influenced competition over mates, as males adjusted their investment in pheromone deposition in response to foreign pheromone streaks. Both sexes adapt their behaviour according to information from olfactory cues in D. grimshawi, but the relative benefits from male–female, as compared to male–male signalling, remain unknown. It seems likely that the pheromone signalling system originally evolved for attracting females to leks. The transition to a signalling system for conveying information about individuals may well, however, at least in part have been driven by benefits from male–male signalling.

Widemo, Fredrik; Johansson, Bjorn G

2005-01-01

395

Are Male Teachers Really Necessary?  

ERIC Educational Resources Information Center

|There are currently no significant policies or programs to address the underrepresentation of males in the early childhood and primary education teaching profession in New Zealand. This paper examines the reasons for male underrepresentation and presents arguments for and against the employment of male teachers in these fields. Reasons cited for…

Farquhar, Sarah

396

Recurrent myocardial infarction with patent coronary arteries.  

PubMed Central

Two separate episodes of severe chest pain occurred several years apart in a 25-year-old male patient with typical clinical findings of acute myocardial infarction with each episode. Cardiac catheterization following the second infarction confirmed the presence of myocardial dysfunction with apical akinesis and dyskinesis. Both coronary arteries were radiologically patent; however, there was evidence of probable recanalization of the right coronary artery. Several months later, the patient developed flank pain, hematuria, progressive renal failure, and cardiac decompensation, and died with intractable arrhythmias. At autopsy, a large apical mitral thrombosis was found and was the presumptive source of multiple systemic emboli. Images Figure 3 Figure 4

Haywood, L. J.; Khan, A. H.; Bornheimer, J.; Finck, E.; Tatter, D.

1997-01-01

397

General Practitioner Liabilities  

Microsoft Academic Search

\\u000a \\u000a A 25-year-old male presented\\u000a to his family physician (FP) with a history of general malaise and fatigue of 6 weeks in duration. He had felt intermittently\\u000a chilly on occasions and documented a low-grade fever of 38°C once or twice. The patient’s past medical history was not significant,\\u000a and the physician’s note provided no details of the physical examination. Routine complete

I. W. Fong

398

Meiosis in male Drosophila  

PubMed Central

Meiosis entails sorting and separating both homologous and sister chromatids. The mechanisms for connecting sister chromatids and homologs during meiosis are highly conserved and include specialized forms of the cohesin complex and a tightly regulated homolog synapsis/recombination pathway designed to yield regular crossovers between homologous chromatids. Drosophila male meiosis is of special interest because it dispenses with large segments of the standard meiotic script, particularly recombination, synapsis and the associated structures. Instead, Drosophila relies on a unique protein complex composed of at least two novel proteins, SNM and MNM, to provide stable connections between homologs during meiosis I. Sister chromatid cohesion in Drosophila is mediated by cohesins, ring-shaped complexes that entrap sister chromatids. However, unlike other eukaryotes Drosophila does not rely on the highly conserved Rec8 cohesin in meiosis, but instead utilizes two novel cohesion proteins, ORD and SOLO, which interact with the SMC1/3 cohesin components in providing meiotic cohesion.

McKee, Bruce D.; Yan, Rihui; Tsai, Jui-He

2012-01-01

399

[Dysgenetic male pseudohermaphroditism].  

PubMed

The authors report a case of a dysgenetic male pseudohermaphroditism with a 45,X/46,XY karyotype in a mosaic form, which was diagnosed in an infant. The one-week-old infant was evaluated because of proximal hypospadias and retention of the right testis. The results of hormonal tests were the followings: serum FSH 5.2 mU/ml; LH: 2.0 mU/ml; testosterone: 144.3 ng/dl; androstendione: 0.42 µg/l; 17-hydroxyprogesterone: 1.12 ng/ml. Chromosomal analysis revealed 45,X/46,XY karyotype. Fluorescent in vitro hybridization showed that 51% of the lymphocytes had the Y chromosome and the SRY gene. Analysis of the SRY showed no deletion in the AZF a,b,c regions. Pelvic magnetic resonance imaging indicated the presence of vagina between the bladder and the rectum, and it showed a mass measuring 15×8 mm in the right inguinal canal as well as an oval gonadal mass with a size of 13×7 mm in the left scrotum. During surgical intervention, performed at the age of one, the right gonad was removed and biopsy of the scrotal testis was performed. Histological examination revealed dysgenetic testis in both sides. The authors emphasize the necessity of cytogenetic and endocrinological investigations of newborns with perineoscrotal hypospadia and bilateral or unilateral maldescent testes immediately after birth. Surgical removal of the dysgenetic testicular tissue located in the abdominal cavity and its histological evaluation provides separation of mixed gonadal dysgenesis, dysgenetic male pseudohermaphroditism, bilateral gonadal dysgenesis and ovotestis in the 45,X/46,XY mosaic cases. An accurate evaluation is necessary for a correct sex assignment and for surgical intervention to prevent neoplastic degeneration of the dysgenetic gonad. PMID:22330842

Ságodi, László; Jakab, Janka; Kiss, Akos; Ladányi, Erzsébet; Balogh, Erzsébet; Ujfalusi, Anikó; Papp, Judit; Megyeri, Tímea; Kovács, Judit

2012-02-26

400

Anger Attacks in Depression – Evidence for a Male Depressive Syndrome  

Microsoft Academic Search

Background: It has been proposed that aggression and especially anger attacks play an important role in the symptomatology of depression. Furthermore, it has been hypothesized that these symptoms are more prevalent in males than in females. Methods: We conducted a study in 217 depressed patients (104 females, 113 males) without psychiatric comorbidity using questionnaires. Study subjects had previously been treated

Dietmar Winkler; Edda Pjrek; Siegfried Kasper

2005-01-01

401

Steroid sulfatase gene in XX males.  

PubMed Central

The human X and Y chromosomes pair and recombine at their distal short arms during male meiosis. Recent studies indicate that the majority of XX males arise as a result of an aberrant exchange between X and Y chromosomes such that the testis-determining factor gene (TDF) is transferred from a Y chromatid to an X chromatid. It has been shown that X-specific loci such as that coding for the red cell surface antigen, Xg, are sometimes lost from the X chromosome in this aberrant exchange. The steroid sulfatase functional gene (STS) maps to the distal short arm of the X chromosome proximal to XG. We have asked whether STS is affected in the aberrant X-Y interchange leading to XX males. DNA extracted from fibroblasts of seven XX males known to contain Y-specific sequences in their genomic DNA was tested for dosage of the STS gene by using a specific genomic probe. Densitometry of the autoradiograms showed that these XX males have two copies of the STS gene, suggesting that the breakpoint on the X chromosome in the aberrant X-Y interchange is distal to STS. To obtain more definitive evidence, cell hybrids were derived from the fusion of mouse cells, deficient in hypoxanthine phosphoribosyltransferase, and fibroblasts of the seven XX males. The X chromosomes in these patients could be distinguished from each other when one of three X-linked restriction-fragment-length polymorphisms was used. Hybrid clones retaining a human X chromosome containing Y-specific sequences in the absence of the normal X chromosome could be identified in six of the seven cases of XX males.(ABSTRACT TRUNCATED AT 250 WORDS) Images Figure 1 Figure 2

Mohandas, T K; Stern, H J; Meeker, C A; Passage, M B; Muller, U; Page, D C; Yen, P H; Shapiro, L J

1990-01-01

402

Management and Outcomes of Male Breast Cancer in Zaria, Nigeria  

PubMed Central

Male breast cancer is an uncommon disease accounting for only 1% of all breast cancers. We present the evaluation, treatment and outcome of male patients seen with breast cancer in our institution. Male patients that had histological diagnosis of breast cancer from 2001 to 2010 were retrospectively evaluated. After evaluation patients were treated with modified radical mastectomy. Combination chemotherapy was given to patients with positive axillary lymph nodes. Radiotherapy and hormonal therapy were also employed. There were 57 male patients with breast cancer which accounted for 9% of all breast cancers seen during the study period. Their mean age was 59 ± 2.3 years. The mean tumor diameter was 13 ± 2.5?cm. Fifty three (93%) patients presented with advanced disease including 15 with distant metastasis. Four patients with stage II disease were treated with modified radical mastectomy, chemotherapy and tamoxifen. Of the 30 patients with sage III disease that had modified radical mastectomy, complete axillary clearance and tumor free margins were achieved in 25. Overall 21 (36.8%) patients were tumor free at one year. Overall 5-year survival was 22.8%. In conclusion, male patients with breast cancer present with advanced disease which is associated with poor outcome of treatment.

Ahmed, Adamu; Ukwenya, Yahaya; Abdullahi, Adamu; Muhammad, Iliyasu

2012-01-01

403

Genetic male infertility and mutation of CATSPER ion channels  

PubMed Central

A clinically significant proportion of couples experience difficulty in conceiving a child. In about half of these cases male infertility is the cause and often genetic factors are involved. Despite advances in clinical diagnostics ?50% of male infertility cases remain idiopathic. Based on this, further analysis of infertile males is required to identify new genetic factors involved in male infertility. This review focuses on cation channel of sperm (CATSPER)-related male infertility. It is based on PubMed literature searches using the keywords ‘CATSPER', ‘male infertility', ‘male contraception', ‘immunocontraception' and ‘pharmacologic contraception' (publication dates from January 1979 to December 2009). Previously, contiguous gene deletions including the CATSPER2 gene implicated the sperm-specific CATSPER channel in syndromic male infertility (SMI). Recently, we identified insertion mutations of the CATSPER1 gene in families with recessively inherited nonsyndromic male infertility (NSMI). The CATSPER channel therefore represents a novel human male fertility factor. In this review we summarize the genetic and clinical data showing the role of CATSPER mutation in human forms of NSMI and SMI. In addition, we discuss clinical management and therapeutic options for these patients. Finally, we describe how the CATSPER channel could be used as a target for development of a male contraceptive.

Hildebrand, Michael S; Avenarius, Matthew R; Fellous, Marc; Zhang, Yuzhou; Meyer, Nicole C; Auer, Jana; Serres, Catherine; Kahrizi, Kimia; Najmabadi, Hossein; Beckmann, Jacques S; Smith, Richard J H

2010-01-01

404

Population density influences male-male competition in guppies.  

PubMed

This study tested the general prediction that population density affects male-male competition, female mate choice and the opportunity for sexual selection. By manipulating the density of guppies, Poecilia reticulata, while keeping the sex ratio constant, I found that male mating tactics were phenotypically plastic with respect to density. As density increased, males decreased their courtship displays. Male-male competition and mate searching were highest at intermediate densities. Population density had no significant effect on the total number of copulations, copulatory tactics or the percentage of postcopulatory guarding. Female preference for males with a higher percentage of orange coloration was similar at all density levels. The 'opportunity for sexual selection', which estimates the upper limit to which a selected trait can shift if directional selection is operating and was calculated as the variance in number of copulations per male divided by the square of the mean number of copulations, was negatively associated with population density. This may be due to the decrease in male-male competition at high density rather than female preference which was similar across density treatments. Copyright 1999 The Association for the Study of Animal Behaviour. PMID:10600137

Jirotkul

1999-12-01

405

Patient \\  

Microsoft Academic Search

Contemporary medical decision making has been characterized as a struggle be- tween patients who are reportedly making more demands for medical interventions such as diagnostic tests and prescription drugs and physicians who are encouraged to partner with patients and satisfy them while simultaneously keeping medical costs down. Understanding this dynamic requires attention to the interactional strategies whereby patients indicate what

Virginia Teas Gill

2005-01-01

406

[Human papillomavirus infection in male genitalia].  

PubMed

A prospective and transversal study in 100 patients since January to December of 1994, was done, to know the human papiloma virus infection prevalence in male genitals. The patients were studied by a clinical history, genital area colposcopic revision after acetic acid 5% application, biopsy of the lesion and histopathology study. The patients age was among 16 to 71 years old, with a media of 38.8 years old. The sexual activity beginning was from 12 to 27 years old, with an average of 18 years old. Forty one percent of the patients have had sexual relations with prostitutes, 26% have had sexually transmitted diseases, 9% of the patients referred only 1 sexual mate and 82% had human papiloma virus infection. PMID:8549928

Cano Garfias, R; Villarreal Peral, C; Juárez Azpilcueta, A

1995-10-01

407

Bone Histomorphometry in Male Idiopathic Osteoporosis  

Microsoft Academic Search

The pathogenesis of male osteoporosis at the cellular level is still elusive. We performed histomorphometric analysis of bone\\u000a biopsy samples from 51 eugonadal men with idiopathic osteoporosis. Their median age was 54 (range 29–73) years. Eighty-two\\u000a percent of the patients had a fracture history, and 57% had vertebral fractures. Bone volume, trabecular thickness, wall thickness,\\u000a and osteoid thickness were significantly

Ylva Pernow; Ellen M. Hauge; Kristina Linder; Eilif Dahl; Maria Sääf

2009-01-01

408

Prevalence of Rotavirus, Adenovirus, and Astrovirus Infections among Patients with Acute Gastroenteritis in, Northern Iran  

PubMed Central

Background: The aim of the study was to determine the incidence of non-bacterial acute gastroenteritis associated with diarrheal diseases in Mazandaran Province, northern Iran. Methods: A total of 400 symptomatic cases from patients with acute gastroenteritis from Mazandaran Province in Iran were screened using EIA method for the presence of rotavirus, adenovirus and astrovirus during 2005–2006. Chi-square tests were used for testing relationships between different variables. Results: Rotavirus, adenovirus and astrovirus were detected in 62%, 2.3%, and 3% of samples, respectively. The maximum rate of rotaviruses was detected in the <1-year-old age group, while minimum rate was found in the 10 years and older age group. Astrovirus and adenovirus were detected predominantly in the 2–5-year-old age group of children, with a prevalence of 8.3% and 3.5% respectively. All studied viral gastroenteritis peaked in the winter, and minimum rate were found in summer. Conclusion: Our statistical analyzes indicated that viral gastroenteritis, especially Rota-viral, had the highest number of occurrences in colder seasons notably in winter and more frequently were observed among younger children.

Hamkar, R; Yahyapour, Y; Noroozi, M; Nourijelyani, K; Jalilvand, S; Adibi, L; Vaziri, S; Poor-Babaei, AA; Pakfetrat, A; Savad-Koohi, R

2010-01-01

409

Chiropractic Care for a Patient with Spasmodic Dysphonia Associated with Cervical Spine Trauma  

PubMed Central

Abstract Objective To discuss the diagnosis and response to treatment of spasmodic dysphonia in a 25-year-old female vocalist following an auto accident. Clinical Features The voice disorder and neck pain appeared after the traumatic incident. Examination of the cervical spine revealed moderate pain, muscle spasm and restricted joint motion at C-1 and C-5 on the left side. Cervical range of motion was reduced on left rotation. Bilateral manual muscle testing of the trapezius and sternocleidomastoid muscles, which share innervation with the laryngeal muscles by way of the spinal accessory nerve, were weak on the left side. Pre and post accident voice range profiles (phonetograms) that measure singing voice quality were examined. The pre- and post-accident phonetograms revealed significant reduction in voice intensity and fundamental frequency as measured in decibels and hertz. Intervention and Outcome Low-force chiropractic spinal manipulative therapy to C-1 and C-5 was employed. Following a course of care, the patient's singing voice returned to normal, as well as a resolution of her musculo- skeletal complaints. Conclusion It appears that in certain cases, the singing voice can be adversely affected if neck or head trauma is severe enough. This case proposes that trauma with irritation to the cervical spine nerve roots as they communicate with the spinal accessory, and in turn the laryngeal nerves, may be contributory in some functional voice disorders or muscle tension dysphonia.

Waddell, Roger K.

2005-01-01

410

Chlamydial infection and male infertility: an epidemiological study.  

PubMed

Chlamydia-positive genitourinary infections are common causes of male and female infertility. Semen abnormalities are often associated with Chlamydia infections. A large population of male patients, admitted to our clinic for genitourinary infection, were examined for genitourinary pathogens, including Chlamydia, and for semen abnormalities. There were higher abnormalities semen in Chlamydia-infected patients than either non-Chlamydia-infected or healthy controls. Chlamydia therapy by antimicrobial agents improved semen characteristics. Chlamydia infection contributes to seminal fluid abnormalities and probably to male infertility. A search for chlamydial infection is warranted whenever semen abnormalities are noted. An antimicrobial therapy improves semen quality when effective in eradicating Chlamydia. PMID:2694996

Custo, G M; Lauro, V; Saitto, C; Frongillo, R F

1989-01-01

411

Declining Minamata male birth ratio associated with increased male fetal death due to heavy methylmercury pollution.  

PubMed

The purpose of this retrospective study was to examine the effect of methylmercury pollution on the sex ratio of offspring at birth and of fetuses at stillbirth in Minamata City, Japan, in the 1950s when severe and widespread methylmercury pollution was experienced. In 4 of 5 years from 1955 to 1959 when methylmercury pollution was most severe, lower numbers of male offspring at birth were observed in the city population. The offspring sex distributions from 1950 to 1969 by 5-year period were calculated in the overall population of Minamata City, in the most prevalent area, in fishermen (most heavily exposed occupation group) and among Minamata disease patients using data from birth certificates. We also similarly calculated the sex ratio of stillborn fetuses in the city population using Kumamoto Prefecture's vital statistics on still-birth. Decreases in male births were observed in offspring in the overall city population, in fishermen, and in maternal Minamata disease patients in the city in 1955-1959, when the methylmercury pollution was most severe. An increase in the proportion of male stillborn fetuses in the city was observed at the time. It is possible that male fetuses were more susceptible to the pollution than their female counterparts, and this could be a cause for the lower numbers of male offspring at birth. PMID:11683592

Sakamoto, M; Nakano, A; Akagi, H

2001-10-01

412

Aberrant splicing caused by a MLH1 splice donor site mutation found in a young Japanese patient with Lynch syndrome.  

PubMed

Lynch syndrome, also known as hereditary non-polyposis colorectal cancer, characterized by predisposition to colorectal cancer and other associated cancers, is an autosomal-dominant disorder mainly caused by germline mutations in DNA mismatch repair (MMR) genes such as MLH1, MSH2, and MSH6. Some mutations that disrupt splice donor or acceptor sites cause aberrant mRNA splicing. These mutations are generally considered as pathogenic ones, however, it is sometimes uneasy to accurately predict their pathogenicity without functional assays, particularly when the mutation is a single nucleotide substitution. In this report, we describe a 25-year-old patient with Lynch syndrome who carries a germline variant in a splice donor site of the MLH1 gene (c.790 + 5 G > T), which was first detected among Asian populations. The immunohistochemical analysis revealed loss of MLH1 protein expression in the tumor. Our splicing assay confirmed that the intronic MLH1 variant actually caused aberrant splicing, supporting its pathogenic effect. Our data accumulate more information on the genotype-phenotype relationships in patients with Lynch syndrome. PMID:22766992

Takahashi, Masanobu; Furukawa, Yoichi; Shimodaira, Hideki; Sakayori, Masato; Moriya, Takuya; Moriya, Yoshihiro; Nakamura, Yusuke; Ishioka, Chikashi

2012-12-01

413

Typhoid fever, complicated by myocarditis, in a traveller returning to the UK.  

PubMed

A 25-year-old male returning traveller presented with sudden onset chest pain. An ECG showed infero-lateral ischaemic changes, with an elevated troponin and inflammatory markers. An echocardiogram showed a normal size left ventricle, dynamic systolic function, structurally normal valves and no regional wall motion abnormality. Angiography revealed normal coronary arteries. A diagnosis of myocarditis was made. Five days later, he developed a significant pyrexia and diarrhoea. Salmonella typhi was isolated from blood cultures. The fever and symptoms resolved after 2 weeks of an intravenous third generation cephalosporin and the patient was discharged. PMID:23417944

Shah, Shreena; Dubrey, Simon William

2013-02-15

414

Hereditary Angioedema: Not An Allergy  

PubMed Central

Hereditary angioedema is a genetic disorder due to a deficiency or malfunction of C1 esterase inhibitor. We herein describe a case of 25-year-old male who presented with swelling over face since one day. There was history of similar episodes since two years with gradual subsidence of swelling without any treatment. Investigations revealed grossly reduced complement C4 and C1 esterase inhibitor level. Patient was diagnosed to have hereditary angioedema type 1 and started on stanozolol 2 mg three times a day with no recurrence in one year of follow-up. Hereditary angioedema resembles angioedema of an allergic reaction. However, the cause is different.

Bhivgade, Sanjay; Melkote, Shubha; Ghate, Smita; Jerajani, H R

2012-01-01

415

Isolated cavernous hemangioma: a rare benign lesion of the stomach.  

PubMed

Gastric cavernous hemangioma is a relatively rare benign gastric disease. Here we report the case of a 25-year-old male patient who had been admitted complaining of epigastric pain and hematemesis. Preoperative imaging indicated that the mass lesion palpated in the epigastric region was a probable mesenchymal tumor of gastric origin. Due to the hypervascular nature and submucosal localization of the mass, we did not obtain definitive preoperative diagnosis by endoscopic biopsy. The histologic diagnosis of cavernous hemangioma was confirmed by post-resection histopathologial evaluation of the mass. PMID:23024741

Basbug, Murat; Yavuz, Ridvan; Dablan, Mahmut; Baysal, Birol; Gencoglu, Metehan; Yagmur, Yusuf

2012-09-12

416

Isolated Cavernous Hemangioma: A Rare Benign Lesion of the Stomach  

PubMed Central

Gastric cavernous hemangioma is a relatively rare benign gastric disease. Here we report the case of a 25-year-old male patient who had been admitted complaining of epigastric pain and hematemesis. Preoperative imaging indicated that the mass lesion palpated in the epigastric region was a probable mesenchymal tumor of gastric origin. Due to the hypervascular nature and submucosal localization of the mass, we did not obtain definitive preoperative diagnosis by endoscopic biopsy. The histologic diagnosis of cavernous hemangioma was confirmed by post-resection histopathologial evaluation of the mass.

Basbug, Murat; Yavuz, Ridvan; Dablan, Mahmut; Baysal, Birol; Gencoglu, Metehan; Yagmur, Yusuf

2012-01-01

417

Granular cell tumor--clinically presented as lymphadenopathy.  

PubMed

Granular cell tumors are relatively uncommon benign lesions occurring in almost any part of the body. We report the cytological diagnosis of granular cell tumor in 25-year-old male patient who presented with an inguinal mass clinically suspected to be a lymphadenopathy. Fine needle aspiration revealed polygonal cells with abundant, granular cytoplasm and eccentrically located vesicular nuclei and inconspicuous nucleoli. The histopathological examination of the surgical excision confirmed the diagnosis. If resection is complete, local surgical excision is curative for benign granular cell tumors. Granular cell tumor has a characteristic cytological appearance, and fine-needle aspiration cytology has been suggested to be diagnostic modality of choice. PMID:20432759

L