Science.gov

Sample records for 25th anniversary rejuvenation

  1. Apollo 11 25th Anniversary logo

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This Official NASA commemorative logo marks the 25th anniversary of the first lunar landing. The design incorporates an eagle, from the original Apoll 11 crew insignia, descending toward the lunar surface with an olive branch, symbolizing America's peaceful mission in space. Alternative Headquarters number is 93-HC-312 or 93-H-336.

  2. Hubble 25th Anniversary: NASA Social at Goddard

    NASA Video Gallery

    NASA's Hubble Space Telescope celebrated its 25th anniversary on April 24, 2015. To mark the occasion, NASA's Goddard Space Flight Center in Greenbelt, Maryland -- home of Hubble operations -- host...

  3. 25th anniversary of the Gagarin Cosmonaut Training Center

    NASA Technical Reports Server (NTRS)

    Goreglyad, I.; Shonin, G.

    1985-01-01

    Interviews with retired Major General of Aviation L. Goreglyad and pilot-cosmonaut with the 25th anniversary of the establishment of the Gagarin Cosmonaut Training Center. Major-General Goreglyad, one of the Center's founders, tells of its development. Major General Shonin, one of the first cosmonauts to train there, tells of the tests and procedures leading to his acceptance as a trainee.

  4. Army Medical Department Lessons Learned Program marks 25th anniversary.

    PubMed

    Cannon, David W; McCollum, Jeffery

    2011-11-01

    The year 2010 marked the 25th anniversary of the Center for Army Lessons Learned (CALL) as well as the Army Medical Department (AMEDD) Center and School's Lessons Learned Division. In the aftermath of Operation Urgent Fury in 1983, the Army recognized the need to create an organization whose sole purpose was to collect, review, and analyze lessons learned and created the CALL in 1985 at Fort Leavenworth, Kansas. The AMEDD followed suit and established the Medical Information System/AMEDD Lessons Learned office under the Directorate of Evaluation and Standardization to research and compile lessons learned as the AMEDD's point of contact for the CALL program. Over these past 25 years the AMEDD Center and School Lessons Learned program evolved and underwent organizational realignments, but the overall mission continues to promote changes either directly or indirectly in the AMEDD's Doctrine, Organizations, Training, Leader Development, Materiel, Personnel and Facilities domains and capabilities to provide combat health service support on the battlefield. PMID:22165647

  5. 76 FR 67799 - Pricing for the American Eagle 25th Anniversary Silver Coin Set

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for the American Eagle 25th Anniversary Silver Coin Set AGENCY: United States... price of the American Eagle 25th Anniversary Silver Coin Set. The coin set will be offered for sale at...

  6. National Center for Biotechnology Information Celebrates 25th Anniversary | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn JavaScript on. National Center for Biotechnology Information Celebrates 25th Anniversary Past Issues / Winter 2014 ... Photo courtesy of NLM The National Center for Biotechnology Information (NCBI), a component of NLM, celebrated its ...

  7. Symposium commemorating the 25th anniversary of the discovery of mendelevium

    SciTech Connect

    Seaborg, G.T.

    1980-01-01

    The Symposium honoring the 25th Anniversary of the discovery of mendelevium was held at the Lawrence Berkeley Laboratory on March 28, 1980. The following three papers were presented: Chemical Properties of Mendelevium; Nuclear Properties of Mendelevium; and Radioactive Decay of Md Isotopes. Besides these papers there were introductory remarks, reminiscences, and concluding remarks.

  8. Alumni of High School Internship Program Return for 25th Anniversary to Inspire Current Students | Poster

    Cancer.gov

    The Building 549 auditorium is often packed with high school interns eager to hear a scientific lecture. On April 22, however, the room swelled with interns spanning a wider age range. At the 25th Werner H. Kirsten Student Intern Program (WHK SIP) Anniversary Symposium, incoming, current, and former interns gathered to celebrate the program, which has provided biomedical research experience for local high school seniors.

  9. Hubble’s 25th Anniversary: A Quarter-Century of Discovery and Inspiration

    NASA Astrophysics Data System (ADS)

    Straughn, Amber; Jirdeh, Hussein

    2015-01-01

    April 24, 2015 marks the 25th anniversary of the launch of the Hubble Space Telescope. In its quarter-century in orbit, the Hubble Space Telescope has transformed the way we understand the Universe, helped us find our place among the stars, and paved the way to incredible advancements in science and technology. NASA and ESA, including STScI and partners, will use the 25th anniversary of Hubble's launch as a unique opportunity to communicate to the widest possible audience the significance of the past quarter-century of discovery with the Hubble Space Telescope and to highlight that Hubble will continue to produce groundbreaking science results. We will enhance public understanding of Hubble's many contributions to the scientific world, and will capitalize on Hubble's cultural popularity by emphasizing its' successor, the James Webb Space Telescope. This poster highlights many of the upcoming opportunities to join in the anniversary activities, both in-person and online. Find out more at hubble25th.org and follow #Hubble25 on social media.

  10. [The Citizen Constitution and the 25th anniversary of the Brazilian Unified National Health System (SUS)].

    PubMed

    Paim, Jairnilson Silva

    2013-10-01

    This article, celebrating the 25th anniversary of Brazil's 1988 Constitution, aims to review the country's social policy development, discuss political projects, and analyze challenges for the sustainability of the Unified National Health System (SUS). Based on public policymaking studies, the article revisits the origins of liberal social policy, focused on social assistance, and analyzes the hegemony of U.S. policies targeting poverty and their repercussions for universal policies. After identifying the formulation of political projects in Brazil's democratic transition, it discusses their implications during the various Administrations since 1988, along with the difficulties faced by the National Health System. The article concludes that the political forces occupying government in the last two decades have failed to present a project for the country on the same level as those who drafted the Citizen Constitution. PMID:24127081

  11. The Prospects for Educational Planning. A Workshop Organised by IIEP on the Occasion of Its 25th Anniversary.

    ERIC Educational Resources Information Center

    Caillods, Francoise, Ed.

    In late 1988, on the occasion of its 25th anniversary celebration, the International Institute for Educational Planning organized an international workshop to review the major problems faced by education today and to consider the future of educational planning worldwide. The workshop brought together researchers, planners, and specialists from all…

  12. Highlights of the 25th Anniversary EANM Congress Milan 2012: nuclear medicine and molecular imaging at its best.

    PubMed

    Langsteger, Werner; Beheshti, Mohsen

    2013-09-01

    The European Association of Nuclear Medicine (EANM) celebrated its 25th Anniversary Congress in Milan under the chairmanship of Professor Emilio Bombardieri and the auspices of the Italian Society of Nuclear Medicine. As always, the Congress was a great success: more than 5,530 participants from 88 countries came from Europe and beyond. In spite of limited budgets, industry again made an important contribution: New innovative equipment and tracers demonstrating the latest technology and innovations were presented by 122 companies. This review is a brief summary of the major scientific contributions made in the fields of oncology, multimodality imaging, cardiovascular science, neurology and psychiatry, technological innovation and novel tracers, and in other clinical sciences as well as in radionuclide therapy, which all show promising and great innovations. PMID:23917722

  13. Marshall Space Flight Center 1960-1985: 25th anniversary report

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The Marshall Space FLight Center marks its 25th aniversary with a record of notable achievements. These accomplishments are the essence of the Marshall Center's history. Behind the scenes of the space launches and missions, however, lies the story of challenges faced and problems solved. The highlights of that story are presented. The story is organized not as a straight chronology but as three parallel reviews of the major assignments: propulsion systems and launch vehicles, space science research and technology, and manned space systems. The general goals were to reach space, to know and understand the space environment, and to inhabit and utilize space for the benefit of mankind. Also included is a chronology of major events, presented as a fold-out chart for ready reference.

  14. The MetLife Survey of the American Teacher: Past, Present and Future. A Survey of Teachers, Principals and Students. 25th Anniversary Edition

    ERIC Educational Resources Information Center

    MetLife, Inc., 2008

    2008-01-01

    This report is the twenty-fifth in a series of surveys sponsored annually by MetLife since 1984 as a public service. This 25th anniversary edition includes the views of teachers, principals and students and looks back to the earliest MetLife Surveys to examine how perspectives on teachers, teaching and public education have changed. It documents…

  15. Informing Policy and Practice in Australia's Vocational Education and Training Sector: Reflections and Futures. Proceedings of the 25th Anniversary Forum of the National Centre for Vocational Education Research (Adelaide, South Australia, Australia, March 21, 2007)

    ERIC Educational Resources Information Center

    Curtin, Penelope, Ed.; Loveder, Phil, Ed.

    2007-01-01

    To mark the occasion of its 25th anniversary, the National Centre for Vocational Education Research (NCVER) brought together policy, industry and academic leaders to reflect on the role that research and statistics have played in the development of Australia's vocational education and training (VET) sector. This publication includes the original…

  16. Children's Rights and School Psychology: An Introduction to the Multiple Journal Series Honoring the 25th Anniversary of the United Nations Convention on the Rights of the Child

    ERIC Educational Resources Information Center

    Mcloughlin, Caven S.; Hart, Stuart N.

    2014-01-01

    This year, 2014, is the 25th anniversary of the United Nations Convention on the Rights of the Child--the world's "positive ideology" and its clearest statement of commitments to and respect and aspirations for the dignity of the child. To commemorate this landmark, a program of articles by respected experts has been organized to…

  17. Proceedings of the Anniversary Meeting (25th, Toronto, December 28-29, 1972). Industrial Relations Research Association Series. Index of IRRA Publications 1966-1972.

    ERIC Educational Resources Information Center

    Somers, Gerald G., Ed.

    Papers presented at the 25th meeting of the Industrial Relations Research Association (IRAA) covered issues that are central to industrial relations in North America. Papers and discussions dealt with these major issues: (1) Prices and Income Policy: Comparative Aspects, (2) Dispute Settlement in the Public Sector, (3) Manpower Policies in Canada…

  18. 25th Anniversary Article: Supramolecular Materials for Regenerative Medicine

    PubMed Central

    Boekhoven, Job

    2014-01-01

    In supramolecular materials, molecular building blocks are designed to interact with one another via non-covalent interactions in order to create function. This offers the opportunity to create structures similar to those found in living systems that combine order and dynamics through the reversibility of intermolecular bonds. For regenerative medicine there is a great need to develop materials that signal cells effectively, deliver or bind bioactive agents in vivo at controlled rates, have highly tunable mechanical properties, but at the same time, can biodegrade safely and rapidly after fulfilling their function. These requirements make supramolecular materials a great platform to develop regenerative therapies. This review illustrates the emerging science of these materials and their use in a number of applications for regenerative medicine. PMID:24496667

  19. Naval Training Device Center 25th Anniversary Commemorative Technical Journal.

    ERIC Educational Resources Information Center

    Amico, G. Vincent; Regan, James J.

    Both the technical history of training devices and the issues which currently confront their design and use are discussed by a group of distinguished scientists and engineers. A blend of human factors and engineering paper reflects the twin thrusts that make up the educational tools that are training device systems. (Author)

  20. Apollo-11 25th Arniversary celebration: Space Shuttle Main Engine - Technology Test Bed (SSME-TTB)

    NASA Technical Reports Server (NTRS)

    1994-01-01

    On the 25th Anniversary of the Apollo-11 space launch, Marshall celebrated with a test firing of the Space Shuttle Main Engine at the Technology Test Bed (SSME-TTB). This drew a large crowd who stood in the fields around the test site and watched as plumes of white smoke verified ignition.

  1. EDITORIAL: Inverse Problems' 25th year of publication Inverse Problems' 25th year of publication

    NASA Astrophysics Data System (ADS)

    2008-01-01

    2009 is Inverse Problems' 25th year of publication. In this quarter-century, the journal has established itself as the premier publication venue for inverse problems research. It has matured from its beginnings as a niche journal serving the emerging field of inverse and ill-posed problems to a monthly publication in 2009 covering all aspects of a well-established, vibrant and still-expanding subject. Along with its core readership of pure and applied mathematicians and physicists, Inverse Problems has become widely known across a broad range of researchers in areas such as geophysics, optics, radar, acoustics, communication theory, signal processing and medical imaging, amongst others. The journal's appeal to the inverse problems community and those researchers from the varied fields that encounter such problems can be attributed to our commitment to publishing only the very best papers, and to offering unique services to the community. Besides our regular research papers, which average a remarkably short five months from submission to electronic publication, we regularly publish heavily cited topical review papers and topic-specific special sections, which first appeared in 2004. These highly-downloaded invited articles focus on the latest developments and hot topics in all areas of inverse problems. No other journal in the field offers these features. I am very pleased to take Inverse Problems into its 25th year as Editor-in-Chief. The journal has an impressive tradition of scholarship, established at its inception by the founder and first Editor-in-Chief, Professor Pierre Sabatier. Professor Sabatier envisioned the journal in 1985 as providing a medium for publication of exemplary research in our intrinsically interdisciplinary field. I am glad to say that the support of our authors, readers, referees, Editors-in-Chief, Editorial Boards and Advisory Panels over the years, has resulted in Inverse Problems becoming the top publication in this field, publishing

  2. 25th Anniversary Article: A Soft Future: From Robots and Sensor Skin to Energy Harvesters

    PubMed Central

    Bauer, Siegfried; Bauer-Gogonea, Simona; Graz, Ingrid; Kaltenbrunner, Martin; Keplinger, Christoph; Schwödiauer, Reinhard

    2014-01-01

    Scientists are exploring elastic and soft forms of robots, electronic skin and energy harvesters, dreaming to mimic nature and to enable novel applications in wide fields, from consumer and mobile appliances to biomedical systems, sports and healthcare. All conceivable classes of materials with a wide range of mechanical, physical and chemical properties are employed, from liquids and gels to organic and inorganic solids. Functionalities never seen before are achieved. In this review we discuss soft robots which allow actuation with several degrees of freedom. We show that different actuation mechanisms lead to similar actuators, capable of complex and smooth movements in 3d space. We introduce latest research examples in sensor skin development and discuss ultraflexible electronic circuits, light emitting diodes and solar cells as examples. Additional functionalities of sensor skin, such as visual sensors inspired by animal eyes, camouflage, self-cleaning and healing and on-skin energy storage and generation are briefly reviewed. Finally, we discuss a paradigm change in energy harvesting, away from hard energy generators to soft ones based on dielectric elastomers. Such systems are shown to work with high energy of conversion, making them potentially interesting for harvesting mechanical energy from human gait, winds and ocean waves. PMID:24307641

  3. 25th anniversary article: A soft future: from robots and sensor skin to energy harvesters.

    PubMed

    Bauer, Siegfried; Bauer-Gogonea, Simona; Graz, Ingrid; Kaltenbrunner, Martin; Keplinger, Christoph; Schwödiauer, Reinhard

    2014-01-01

    Scientists are exploring elastic and soft forms of robots, electronic skin and energy harvesters, dreaming to mimic nature and to enable novel applications in wide fields, from consumer and mobile appliances to biomedical systems, sports and healthcare. All conceivable classes of materials with a wide range of mechanical, physical and chemical properties are employed, from liquids and gels to organic and inorganic solids. Functionalities never seen before are achieved. In this review we discuss soft robots which allow actuation with several degrees of freedom. We show that different actuation mechanisms lead to similar actuators, capable of complex and smooth movements in 3d space. We introduce latest research examples in sensor skin development and discuss ultraflexible electronic circuits, light emitting diodes and solar cells as examples. Additional functionalities of sensor skin, such as visual sensors inspired by animal eyes, camouflage, self-cleaning and healing and on-skin energy storage and generation are briefly reviewed. Finally, we discuss a paradigm change in energy harvesting, away from hard energy generators to soft ones based on dielectric elastomers. Such systems are shown to work with high energy of conversion, making them potentially interesting for harvesting mechanical energy from human gait, winds and ocean waves. PMID:24307641

  4. 25th anniversary article: Rise to power--OPV-based solar parks.

    PubMed

    Krebs, Frederik C; Espinosa, Nieves; Hösel, Markus; Søndergaard, Roar R; Jørgensen, Mikkel

    2014-01-01

    A solar park based on polymer solar cells is described and analyzed with respect to performance, practicality, installation speed, and energy payback time. It is found that a high voltage installation where solar cells are all printed in series enables an installation rate in Watts installed per minute that far exceed any other PV technology in existence. The energy payback time for the practical installation of polymer solar cell foil on a wooden 250 square meter platform in its present form is 277 days when operated in Denmark and 180 days when operated in southern Spain. The installation and de-installation rate is above 100 m min⁻¹, which, with the present performance and web width, implies installation of >200 W min⁻¹. In comparison, this also exceeds the overall manufacturing speed of the polymer solar cell foil with a width of 305 mm which is currently 1 m min⁻¹ for complete encapsulated and tested foil. It is also significant that simultaneous installation and de-installation which enables efficient schemes for decommissioning and recycling is possible. It is highlighted where research efforts should most rationally be invested in order to make grid electricity from OPV a reality (and it is within reach). PMID:24741693

  5. 25th anniversary article: label-free electrical biodetection using carbon nanostructures.

    PubMed

    Balasubramanian, Kannan; Kern, Klaus

    2014-02-26

    Nanostructures are promising candidates for use as active materials for the detection of chemical and biological species, mainly due to the high surface-to-volume ratio and the unique physical properties arising at the nanoscale. Among the various nanostructures, materials comprised of sp(2) -carbon enjoy a unique position due to the possibility to readily prepare them in various dimensions ranging from 0D, through 1D to 2D. This review focuses on the use of 1D (carbon nanotubes) and 2D (graphene) carbon nanostructures for the detection of biologically relevant molecules. A key advantage is the possibility to perform the sensing operation without the use of any labels or complex reaction schemes. Along this spirit, various strategies reported for the label-free electrical detection of biomolecules using carbon nanostructures are discussed. With their promise for ultimate sensitivity and the capability to attain high selectivity through controlled chemical functionalization, carbon-based nanobiosensors are expected to open avenues to novel diagnostic tools as well as to obtain new fundamental insight into biomolecular interactions down to the single molecule level. PMID:24452968

  6. A resolution recognizing the 25th anniversary of the Chernobyl nuclear disaster.

    THOMAS, 112th Congress

    Sen. Lugar, Richard G. [R-IN

    2011-04-14

    05/09/2011 Resolution agreed to in Senate with an amendment and with a preamble by Unanimous Consent. (text: CR S2799) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  7. 25th anniversary article: semiconductor nanowires--synthesis, characterization, and applications.

    PubMed

    Dasgupta, Neil P; Sun, Jianwei; Liu, Chong; Brittman, Sarah; Andrews, Sean C; Lim, Jongwoo; Gao, Hanwei; Yan, Ruoxue; Yang, Peidong

    2014-04-01

    Semiconductor nanowires (NWs) have been studied extensively for over two decades for their novel electronic, photonic, thermal, electrochemical and mechanical properties. This comprehensive review article summarizes major advances in the synthesis, characterization, and application of these materials in the past decade. Developments in the understanding of the fundamental principles of "bottom-up" growth mechanisms are presented, with an emphasis on rational control of the morphology, stoichiometry, and crystal structure of the materials. This is followed by a discussion of the application of nanowires in i) electronic, ii) sensor, iii) photonic, iv) thermoelectric, v) photovoltaic, vi) photoelectrochemical, vii) battery, viii) mechanical, and ix) biological applications. Throughout the discussion, a detailed explanation of the unique properties associated with the one-dimensional nanowire geometry will be presented, and the benefits of these properties for the various applications will be highlighted. The review concludes with a brief perspective on future research directions, and remaining barriers which must be overcome for the successful commercial application of these technologies. PMID:24604701

  8. Development and External Debt: Friend or Foe? Academy for Educational Development 25th Anniversary Seminar Series.

    ERIC Educational Resources Information Center

    Hope, Nicholas C.

    Arguing that the benefits from borrowing abroad exceed the costs recently imposed on countries through debt-servicing difficulties, this paper defines debt as an engine of growth, forcing the borrower to produce goods efficiently, export them, and function competitively in the international market. Debt-servicing difficulties of developing nations…

  9. A resolution honoring the Blackstone Valley Tourism Council on the celebration of its 25th anniversary.

    THOMAS, 111th Congress

    Sen. Whitehouse, Sheldon [D-RI

    2010-03-24

    04/14/2010 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (text: CR S2326) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  10. AIDS: The Global Impact. Academy for Educational Development 25th Anniversary Seminar Series.

    ERIC Educational Resources Information Center

    Mann, Jonathan

    This paper describes why acquired immune deficiency syndrome (AIDS) is a global health problem and discusses special features of the virus and its infection. This disease's transmission and interaction with other diseases, along with 1986 statistics concerning AIDS, are presented in terms of selected continents and countries. The World Health…

  11. Newspapers on Microfilm. Catalog and Price List 1971, 25th Anniversary Edition.

    ERIC Educational Resources Information Center

    1971

    Over 5500 current and backfile titles of American, foreign, and Black community newspapers that may be purchased on 35mm. roll microfilm are indexed in this catalog. Historical annotations are provided for selected American, Asian, and other foreign newspapers as well as for collections which focus on areas of special interest: early America, the…

  12. 25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine

    PubMed Central

    Annabi, Nasim; Tamayol, Ali; Uquillas, Jorge Alfredo; Akbari, Mohsen; Bertassoni, Luiz E.; Cha, Chaenyung; Camci-Unal, Gulden; Dokmeci, Mehmet R.

    2014-01-01

    Hydrogels are hydrophilic polymer-based materials with high water content and physical characteristics that resemble the native extracellular matrix. Because of their remarkable properties, hydrogel systems are used for a wide range of biomedical applications, such as three-dimensional (3D) matrices for tissue engineering, drug-delivery vehicles, composite biomaterials, and as injectable fillers in minimally invasive surgeries. In addition, the rational design of hydrogels with controlled physical and biological properties can be used to modulate cellular functionality and tissue morphogenesis. Here, the development of advanced hydrogels with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light-sensitive, composite, and shape-memory hydrogels. Emerging technologies developed over the past decade to control hydrogel architecture are also discussed and a number of potential applications and challenges in the utilization of hydrogels in regenerative medicine are reviewed. It is anticipated that the continued development of sophisticated hydrogels will result in clinical applications that will improve patient care and quality of life. PMID:24741694

  13. 25th anniversary article: key points for high-mobility organic field-effect transistors.

    PubMed

    Dong, Huanli; Fu, Xiaolong; Liu, Jie; Wang, Zongrui; Hu, Wenping

    2013-11-20

    Remarkable progress has been made in developing high performance organic field-effect transistors (OFETs) and the mobility of OFETs has been approaching the values of polycrystalline silicon, meeting the requirements of various electronic applications from electronic papers to integrated circuits. In this review, the key points for development of high mobility OFETs are highlighted from aspects of molecular engineering, process engineering and interface engineering. The importance of other factors, such as impurities and testing conditions is also addressed. Finally, the current challenges in this field for practical applications of OFETs are further discussed. PMID:24105677

  14. 25th anniversary article: progress in chemistry and applications of functional indigos for organic electronics.

    PubMed

    Głowacki, Eric Daniel; Voss, Gundula; Sariciftci, Niyazi Serdar

    2013-12-17

    Indigo and its derivatives are dyes and pigments with a long and distinguished history in organic chemistry. Recently, applications of this 'old' structure as a functional organic building block for organic electronics applications have renewed interest in these molecules and their remarkable chemical and physical properties. Natural-origin indigos have been processed in fully bio-compatible field effect transistors, operating with ambipolar mobilities up to 0.5 cm(2) /Vs and air-stability. The synthetic derivative isoindigo has emerged as one of the most successful building-blocks for semiconducting polymers for plastic solar cells with efficiencies > 5%. Another isomer of indigo, epindolidione, has also been shown to be one of the best reported organic transistor materials in terms of mobility (∼2 cm(2) /Vs) and stability. This progress report aims to review very recent applications of indigoids in organic electronics, but especially to logically bridge together the hereto independent research directions on indigo, isoindigo, and other materials inspired by historical dye chemistry: a field which was the root of the development of modern chemistry in the first place. PMID:24151199

  15. 25th anniversary article: CVD polymers: a new paradigm for surface modification and device fabrication.

    PubMed

    Coclite, Anna Maria; Howden, Rachel M; Borrelli, David C; Petruczok, Christy D; Yang, Rong; Yagüe, Jose Luis; Ugur, Asli; Chen, Nan; Lee, Sunghwan; Jo, Won Jun; Liu, Andong; Wang, Xiaoxue; Gleason, Karen K

    2013-10-11

    Well-adhered, conformal, thin (<100 nm) coatings can easily be obtained by chemical vapor deposition (CVD) for a variety of technological applications. Room temperature modification with functional polymers can be achieved on virtually any substrate: organic, inorganic, rigid, flexible, planar, three-dimensional, dense, or porous. In CVD polymerization, the monomer(s) are delivered to the surface through the vapor phase and then undergo simultaneous polymerization and thin film formation. By eliminating the need to dissolve macromolecules, CVD enables insoluble polymers to be coated and prevents solvent damage to the substrate. CVD film growth proceeds from the substrate up, allowing for interfacial engineering, real-time monitoring, and thickness control. Initiated-CVD shows successful results in terms of rationally designed micro- and nanoengineered materials to control molecular interactions at material surfaces. The success of oxidative-CVD is mainly demonstrated for the deposition of organic conducting and semiconducting polymers. PMID:24115244

  16. The Hawaii Undersea Research Laboratory's 25th Anniversary Expedition to the South Pacific

    NASA Astrophysics Data System (ADS)

    Smith, J. R.; Wiltshire, J. C.; Malahoff, A.

    2005-12-01

    The Hawaii Undersea Research Laboratory (HURL) was established by NOAA at the University of Hawaii 25 years ago as part of its National Undersea Research Program. HURL's mission is to study deep water marine processes in the Pacific Ocean through a competitive proposal and review process. The dual Pisces IV and Pisces V 2000-meter manned submersibles, an RCV-150 1000-meter ROV, and multibeam equipped support ship R/V Ka'imikai-o-Kanaloa ( KoK) were largely acquired from the petroleum industry then adapted and upgraded to carry out cutting edge scientific expeditions. These studies range from active submarine volcanoes, delicate precious coral gardens, endangered marine mammal and fisheries management, to engineering surveys and deployment of observatory systems. HURL successfully completed a major 5-month expedition to the South Pacific during March-August 2005, working in the waters of New Zealand, Tonga, American Samoa, and the U.S. Line Islands covering a distance of nearly 14,500 nautical miles. This mission was significant in both the scientific merit and scope of operations, consisting of 8 different cruise legs at 21 study sites, with 12 chief and co-chief scientists, 58 total science team participants, and completing 61 out of 56 scheduled Pisces science dives, 17 ROV dives, 5 multibeam survey areas, 6 CTD rosette deployments, and 7 instrument mooring recoveries. The $3.5 million expedition was funded by an international partnership with New Zealand agencies (GNS & NIWA) and the University of Kiel in Germany along with the NOAA Office of Exploration and National Undersea Research Program. While most of the individual cruise legs focused on active submarine volcanoes of the Tonga-Kermadec Islands Arc and the Samoan hot spot chain with their hydrothermal systems and associated biological communities, others concentrated on marine protected areas including those of American Samoa and the remote atolls of the Line Islands of the Central Pacific. These studies included biological habitat mapping, climate change from dating of precious coral growth rings, ecological inventory assessments, and the marine archeology and impact from a grounded vessel. An overview of the latter portion of the voyage will be presented, along with the general capabilities of the HURL systems, and how they may be utilized by others employing the international collaborative model for extended missions to remote locations in the pursuit of deep submergence science.

  17. 25th Anniversary Article: Organic Field-Effect Transistors: The Path Beyond Amorphous Silicon

    PubMed Central

    Sirringhaus, Henning

    2014-01-01

    Over the past 25 years, organic field-effect transistors (OFETs) have witnessed impressive improvements in materials performance by 3–4 orders of magnitude, and many of the key materials discoveries have been published in Advanced Materials. This includes some of the most recent demonstrations of organic field-effect transistors with performance that clearly exceeds that of benchmark amorphous silicon-based devices. In this article, state-of-the-art in OFETs are reviewed in light of requirements for demanding future applications, in particular active-matrix addressing for flexible organic light-emitting diode (OLED) displays. An overview is provided over both small molecule and conjugated polymer materials for which field-effect mobilities exceeding > 1 cm2 V–1 s–1 have been reported. Current understanding is also reviewed of their charge transport physics that allows reaching such unexpectedly high mobilities in these weakly van der Waals bonded and structurally comparatively disordered materials with a view towards understanding the potential for further improvement in performance in the future. PMID:24443057

  18. 25th anniversary of the deep manned submersibles Mir- 1 and Mir- 2

    NASA Astrophysics Data System (ADS)

    Sagalevitch, A. M.

    2012-11-01

    In 1987, the deep manned submersibles Mir- 1 and Mir- 2 were introduced into the practice of scientific research of the ocean. For 25 years, with their help, a wide range of deepwater operations have been carried out: oceanic scientific research (including the most active areas on the seabed—hydrothermal fields), shooting films and documentaries, which have brought international fame to the vehicles; special operations concerning solving problems of national importance concerning the sunken nuclear submarines Komsomolets and Kursk; live television broadcast from great depths of the ocean via satellite to the earth; diving under the ice at the geographic North Pole; a three-year cycle of scientific research on lake Baikal; etc. During the 25 years of their operation, there have been no unsolvable problems in the deep ocean for the Mir vehicles. They have rightfully taken a leading position in the field of deep-sea research in the world and were named the best vehicles in technical terms in the history of the creation of such technical facilities. Some of the results and details of the above-mentioned deep-sea operations, as well as the technical innovations developed and implemented during the service of the Mir vehicles, are considered in this article.

  19. [To the 25th anniversary of commencement of perestroika of national public health].

    PubMed

    Juravleva, T V; Khmel, A A

    2012-01-01

    The process of modernization of public health of the Russian Federation requires the application of experience of resent past. In 2012, is 25 years from the day of approval of the decree "The main directions of development of population health protection and perestroika of public health of the USSR in 12th five-year plan and to the period up to 2000". Many items of this document remained unrealized due to the change of social political course of country progression. Nevertheless, these items can be used presently to enhance the legislation in public health sector. PMID:23634616

  20. 25th anniversary article: carbon nanotube- and graphene-based transparent conductive films for optoelectronic devices.

    PubMed

    Du, Jinhong; Pei, Songfeng; Ma, Laipeng; Cheng, Hui-Ming

    2014-04-01

    Carbon nanotube (CNT)- and graphene (G)-based transparent conductive films (TCFs) are two promising alternatives for commonly-used indium tin oxide-based TCFs for future flexible optoelectronic devices. This review comprehensively summarizes recent progress in the fabrication, properties, modification, patterning, and integration of CNT- and G-TCFs into optoelectronic devices. Their potential applications and challenges in optoelectronic devices, such as organic photovoltaic cells, organic light emitting diodes and touch panels, are discussed in detail. More importantly, their key characteristics and advantages for use in these devices are compared. Despite many challenges, CNT- and G-TCFs have demonstrated great potential in various optoelectronic devices and have already been used for some products like touch panels of smartphones. This illustrates the significant opportunities for the industrial use of CNTs and graphene, and hence pushes nanoscience and nanotechnology one step towards practical applications. PMID:24591083

  1. 25th anniversary article: polymer-particle composites: phase stability and applications in electrochemical energy storage.

    PubMed

    Srivastava, Samanvaya; Schaefer, Jennifer L; Yang, Zichao; Tu, Zhengyuan; Archer, Lynden A

    2014-01-15

    Polymer-particle composites are used in virtually every field of technology. When the particles approach nanometer dimensions, large interfacial regions are created. In favorable situations, the spatial distribution of these interfaces can be controlled to create new hybrid materials with physical and transport properties inaccessible in their constituents or poorly prepared mixtures. This review surveys progress in the last decade in understanding phase behavior, structure, and properties of nanoparticle-polymer composites. The review takes a decidedly polymers perspective and explores how physical and chemical approaches may be employed to create hybrids with controlled distribution of particles. Applications are studied in two contexts of contemporary interest: battery electrolytes and electrodes. In the former, the role of dispersed and aggregated particles on ion-transport is considered. In the latter, the polymer is employed in such small quantities that it has been historically given titles such as binder and carbon precursor that underscore its perceived secondary role. Considering the myriad functions the binder plays in an electrode, it is surprising that highly filled composites have not received more attention. Opportunities in this and related areas are highlighted where recent advances in synthesis and polymer science are inspiring new approaches, and where newcomers to the field could make important contributions. PMID:24323839

  2. Cartography and Connectomes Perspective article for Neuron 25th Anniversary Issue

    PubMed Central

    Van Essen, David C.

    2013-01-01

    The past 25 years have seen great progress in parcellating the cerebral cortex into a mosaic of many distinct areas in mice, monkeys, and humans. Quantitative studies of inter-areal connectivity have revealed unexpectedly many pathways and a wide range of connection strengths in mouse and macaque cortex. In humans, advances in analyzing ‘structural’ and ‘functional’ connectivity using powerful but indirect noninvasive neuroimaging methods are yielding intriguing insights about brain circuits, their variability across individuals, and their relationship to behavior. PMID:24183027

  3. National Center for Biotechnology Information Celebrates 25th Anniversary | NIH MedlinePlus the Magazine

    MedlinePlus

    ... http://m.medlineplus.gov/spanish Tune in: NIH Radio Free podcast audio reports on your computer or personal audio player www.nih.gov/news/radio/nihpodcast.htm Winter 2014 Issue: Volume 8 Number ...

  4. Introductory address by Dr Demissie Habte on the occasion of the 25th anniversary of ORS.

    PubMed

    Habte, D

    1994-01-01

    In Bangladesh, the director of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) gave the introductory address at an awards ceremony to celebrate its key role in the discovery of oral rehydration solution (ORS) 25 years ago. ORS, a simple and affordable treatment for diarrheal disease, has specific amounts of glucose, salts, and water. Oral rehydration therapy (ORT) includes ORS and other solutions made with effective and safe salt concentrations and cereals. In South Asia, rock salt with cooked rice in a thick gruel was used to treat diarrhea as long as 3000 years ago. Researchers at the Cholera Research Laboratory in Dhaka during 1964-1968 learned that adding glucose to a solution of salts greatly helps the intestine's ability to absorb water and electrolytes, and that the intestine could absorb them during acute diarrhea. In November, 1987, the researchers set up a large scale field treatment center at a hospital in Malumghat, between Cox's Bazaar and Chittagong. It treated more than 300 cholera patients. No one died, but the trial was a failure. The researchers designed another clinical trial which showed that ORS reduced the need for intravenous fluids by 75% when treating acute cholera in adults. Another ORS trial in Calcutta yielded the same results. The laboratory also showed that ORS alone could rehydrate people with acute dehydrating diarrhea and that medical auxiliaries could administer it. In 1971, ORS successfully treated Bangladeshi refugees with cholera. The international health community officially accepted ORT in 1978. In developed countries, the potential health care cost savings of ORS use is greater than a few billion dollars at the very least and US$ 10-15 billion from optimal ORS use. Government officials from what is now Bangladesh and the US established the Cholera Research Laboratory 32 years ago. 18 years later, it became ICDDR,B. We must recognize the miracle of ORS. PMID:12345476

  5. 1984-2008. Predictions for Higher Education. From the 25th Anniversary Colloquium. [Proceedings].

    ERIC Educational Resources Information Center

    Hardee, Melvene Draheim, Ed.

    Predictions on higher education for 1984-2009 are presented in the proceedings of a colloquium of the Institute for Studies in Higher Education of Florida State University. Presentations were made at the colloquium by 10 graduates of the university whose current positions represent administration-management, instruction, research, and student…

  6. 25th Anniversary Article: Ordered Polymer Structures for the Engineering of Photons and Phonons

    PubMed Central

    Lee, Jae-Hwang; Koh, Cheong Yang; Singer, Jonathan P; Jeon, Seog-Jin; Maldovan, Martin; Stein, Ori; Thomas, Edwin L

    2014-01-01

    The engineering of optical and acoustic material functionalities via construction of ordered local and global architectures on various length scales commensurate with and well below the characteristic length scales of photons and phonons in the material is an indispensable and powerful means to develop novel materials. In the current mature status of photonics, polymers hold a pivotal role in various application areas such as light-emission, sensing, energy, and displays, with exclusive advantages despite their relatively low dielectric constants. Moreover, in the nascent field of phononics, polymers are expected to be a superior material platform due to the ability for readily fabricated complex polymer structures possessing a wide range of mechanical behaviors, complete phononic bandgaps, and resonant architectures. In this review, polymer-centric photonic and phononic crystals and metamaterials are highlighted, and basic concepts, fabrication techniques, selected functional polymers, applications, and emerging ideas are introduced. PMID:24338738

  7. Literacy: Celebration and Challenge. Illinois Reading Council Silver Anniversary Monograph.

    ERIC Educational Resources Information Center

    Johns, Jerry L., Ed.; And Others

    Celebrating the Illinois Reading Council's 25th anniversary year, this 2-part monograph presents 11 papers on diverse aspects of reading and literacy. Papers in the first part, called "Historical Reflections and Challenges," are: "The Illinois Reading Council Celebrates 25 Years" (John W. Logan); "The 'Illinois Reading Council Journal':…

  8. Graduate Education--Past--Present--Future. Proceedings of the Annual Meeting of the Council of Graduate Schools in the United States (25th, Anaheim, California, December 11-14, 1985).

    ERIC Educational Resources Information Center

    Khalil, Edna M., Ed.

    This proceedings document contains papers presented at the 25th anniversary meeting of the Council of Graduate Schools in the United States (CGS); information on the CGS business meeting, notices of awards presentations, copies of the CGS constitution and bylaws, and a CGS membership list. Topics and presenters are as follows: "Current Issues in…

  9. Neck skin rejuvenation.

    PubMed

    Duplechain, J Kevin

    2014-05-01

    The author of this article uses the pulsed ablative CO2 laser for resurfacing of the neck and face, based on the gold standard status of the CO2 laser and a novel post-treatment plan that greatly reduces adverse effects traditionally associated with fully ablative resurfacing. The croton oil peel is an inexpensive and effective modality for rejuvenating neck skin. The use of either technique as an adjunct to neck lift surgery, with or without facelift surgery, permits surgeons to fulfill the expectations of patients who want the skin of their face and neck to be homogeneous and more attractive. PMID:24745383

  10. Proceedings of the 25th intersociety energy conversion engineering conference

    SciTech Connect

    Nelson, P.A.; Schertz, W.W.; Till, R.H.

    1990-01-01

    This book contains the proceedings of the 25th Intersociety Energy Conversion Engineering Conference. Volume 5 is organized under the following headings: Photovoltaics I, Photovoltaics II, Geothermal power, Thermochemical conversion of biomass, Energy from waste and biomass, Solar thermal systems for environmental applications, Solar thermal low temperature systems and components, Solar thermal high temperature systems and components, Wind systems, Space power sterling technology Stirling cooler developments, Stirling solar terrestrial I, Stirling solar terrestrial II, Stirling engine generator sets, Stirling models and simulations, Stirling engine analysis, Stirling models and simulations, Stirling engine analysis, Stirling engine loss understanding, Novel engine concepts, Coal conversion and utilization, Power cycles, MHD water propulsion I, Underwater vehicle powerplants - performance, MHD underwater propulsion II, Nuclear power, Update of advanced nuclear power reactor concepts.

  11. Combination hand rejuvenation procedures.

    PubMed

    Shamban, Ava T

    2009-01-01

    Although the hands age at the same rate as the face, the aging process differs and requires a combination treatment approach for optimal rejuvenation. Photoaging causes epidermal changes such as lentigines, actinic keratoses, fine wrinkles, and crepe-like textural change. Thinning of the dermis and subcutaneous fat occurs as a result of both ultraviolet light exposure and intrinsic aging. This process can lead to a skeletal appearance of the hands, with prominent veins and bulging tendons. The combination approach addresses all of these issues, employing lasers, intense pulsed light devices, fractional devices, fillers, peels, vein sclerotherapy, and an effective at-home skin care program as indicated for individual needs and concerns. PMID:19825471

  12. Witnessing Solar Rejuvenation

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2015-09-01

    At the end of last year, the Suns large-scale magnetic field suddenly strengthened, reaching its highest value in over two decades. Here, Neil Sheeley and Yi-Ming Wang (both of the Naval Research Laboratory) propose an explanation for why this happened and what it predicts for the next solar cycle.Magnetic StrengtheningUntil midway through 2014, solar cycle 24 the current solar cycle was remarkably quiet. Even at its peak, it averaged only 79 sunspots per year, compared to maximums of up to 190 in recent cycles. Thus it was rather surprising when, toward the end of 2014, the Suns large-scale magnetic field underwent a sudden rejuvenation, with its mean field leaping up to its highest values since 1991 and causing unprecedentedly large numbers of coronal loops to collapse inward.Yet in spite of the increase we observed in the Suns open flux (the magnetic flux leaving the Suns atmosphere, measured from Earth), there was not a significant increase in solar activity, as indicated by sunspot number and the rate of coronal mass ejections. This means that the number of sources of magnetic flux didnt increase so Sheeley and Wang conclude that flux must instead have been emerging from those sources in a more efficient way! But how?Aligned ActivityWSO open flux and the radial component of the interplanetary magnetic field (measures of the magnetic flux leaving the Suns photosphere and heliosphere, respectively), compared to sunspot number (in units of 100 sunspots). A sudden increase in flux is visible after the peak of each of the last four sunspot cycles. Click for a larger view! [Sheeley Wang 2015]The authors show that the active regions on the solar surface in late 2014 lined up in such a way that the emerging flux was enhanced, forming a strong equatorial dipole field that accounts for the sudden rejuvenation observed.Interestingly, this rejuvenation of the Suns open flux wasnt just a one-time thing; similar bursts have occurred shortly after the peak of every sunspot

  13. 25th PolyMAC Conference, June 13-15, 1995

    SciTech Connect

    Smith, P.F.

    1995-06-01

    This document contains abstracts of reports presented at the 25th Annual Polymeric, Materials, Adhesives and Composites Symposium. Reports covered aging, testing and performance, and encapsulating materials.

  14. Rejuvenation of spiral bulges

    NASA Astrophysics Data System (ADS)

    Thomas, Daniel; Davies, Roger L.

    2006-02-01

    We seek to understand whether the stellar populations of galactic bulges show evidence of secular evolution triggered by the presence of the disc. For this purpose, we re-analyse the sample of Proctor and Sansom, deriving stellar population ages and element abundances from absorption-line indices as functions of central velocity dispersion and Hubble type. We obtain consistent constraints on ages from the three Balmer-line indices Hβ, Hγ and Hδ, based on stellar population models that take the abundance ratio effects on these indices into account. Emission-line contamination turns out to be a critical aspect, which favours the use of the higher order Balmer-line indices. Our derived ages are consistent with those of Proctor and Sansom based on a completely different method. In agreement with other studies in the literature, we find that bulges have relatively low luminosity weighted ages, the lowest age derived being 1.3Gyr. Hence, bulges are not generally old, but actually rejuvenated systems. We discuss evidence that this might be true also for the bulge of the Milky Way. The data reveal clear correlations of all three parameters luminosity weighted age, total metallicity and α/Fe ratio with central velocity dispersion. The smallest bulges are the youngest with the lowest α/Fe ratios owing to late Fe enrichment from Type Ia supernovae. Using models combining recent minor star formation with a base old population, we show that the smallest bulges must have experienced significant star formation events involving 10-30 per cent of their total mass in the past 1-2Gyr. No significant correlations of the stellar population parameters with Hubble type are found. We show that the above relationships with σ coincide perfectly with those of early-type galaxies. In other words, bulges are typically younger, metal poorer and less α/Fe enhanced than early-type galaxies because of their smaller masses. At a given velocity dispersion, bulges and elliptical galaxies are

  15. Proceedings of the 25th Himalaya-Karakoram-Tibet Workshop

    USGS Publications Warehouse

    Leech, Mary L.; Klemperer, Simon L.; Mooney, Walter D.

    2010-01-01

    For a quarter of a century the Himalayan-Karakoram-Tibet (HKT) Workshop has provided scientists studying the India-Asia collision system a wonderful opportunity for workshop-style discussion with colleagues working in this region. In 2010, HKT returns to North America for the first time since 1996. The 25th international workshop is held from June 7 to10 at San Francisco State University, California. The international community was invited to contribute scientific papers to the workshop, on all aspects of geoscience research in the geographic area of the Tibetan Plateau and its bounding ranges and basins, from basic mapping to geochemical and isotopic analyses to large-scale geophysical imaging experiments. In recognition of the involvement of U.S. Geological Survey (USGS) scientists in a wide range of these activities, the USGS agreed to publish the extended abstracts of the numerous components of HKT-25 as an online Open-File Report, thereby ensuring the wide availability and distribution of these abstracts, particularly in the HKT countries from which many active workers are precluded by cost from attending international meetings. In addition to the workshop characterized by contributed presentations, participants were invited to attend a pre-meeting field trip from the Coast Ranges to the Sierra Nevada, to allow the international group to consider how the tectonic elements of the Pacific margin compare to those of the Himalayan belt. Following the workshop, the National Science Foundation (NSF) sponsored a workshop on the 'Future directions for NSF-sponsored geoscience research in the Himalaya/Tibet' intended to provide NSF Program Directors with a clear statement and vision of community goals for the future, including the scientific progress we can expect if NSF continues its support of projects in this geographic region, and to identify which key geoscience problems and processes are best addressed in the Himalaya and Tibet, what key datasets are needed, and

  16. 25th anniversary article: The evolution of electronic skin (e-skin): a brief history, design considerations, and recent progress.

    PubMed

    Hammock, Mallory L; Chortos, Alex; Tee, Benjamin C-K; Tok, Jeffrey B-H; Bao, Zhenan

    2013-11-13

    Human skin is a remarkable organ. It consists of an integrated, stretchable network of sensors that relay information about tactile and thermal stimuli to the brain, allowing us to maneuver within our environment safely and effectively. Interest in large-area networks of electronic devices inspired by human skin is motivated by the promise of creating autonomous intelligent robots and biomimetic prosthetics, among other applications. The development of electronic networks comprised of flexible, stretchable, and robust devices that are compatible with large-area implementation and integrated with multiple functionalities is a testament to the progress in developing an electronic skin (e-skin) akin to human skin. E-skins are already capable of providing augmented performance over their organic counterpart, both in superior spatial resolution and thermal sensitivity. They could be further improved through the incorporation of additional functionalities (e.g., chemical and biological sensing) and desired properties (e.g., biodegradability and self-powering). Continued rapid progress in this area is promising for the development of a fully integrated e-skin in the near future. PMID:24151185

  17. The Role of SoTL in the Academy: Upon the 25th Anniversary of Boyer's "Scholarship Reconsidered"

    ERIC Educational Resources Information Center

    Kern, Beth; Mettetal, Gwendolyn; Dixson, Marcia D.; Morgan, Robin K.

    2015-01-01

    In this essay, we explore definitions and taxonomies of the Scholarship of Teaching and Learning (SoTL) and present a model of the Dimensions of Activities Related to Teaching (DART) which provides a context for SoTL along two dimensions: public/private and systematic/informal. The four quadrants: practice of teaching, sharing about teaching,…

  18. The Anesthesia Patient Safety Foundation at 25: a pioneering success in safety, 25th anniversary provokes reflection, anticipation.

    PubMed

    Eichhorn, John H

    2012-04-01

    The Anesthesia Patient Safety Foundation (APSF) was created in 1985. Its founders coined the term "patient safety" in its modern public usage and created the very first patient safety organization, igniting a movement that is now universal in all of health care. Driven by the vision "that no patient shall be harmed by anesthesia," the APSF has worked tirelessly for more than a quarter century to promote safety education and communication through its widely read Newsletter, its programs, and its presentations. The APSF's extensive research grant program has supported a great many projects leading to key safety improvements and, in particular, was central in the development of high-fidelity mannequin simulation as a research and teaching tool. With its pioneering collaboration, the APSF is unique in incorporating the talents and resources of anesthesia professionals of all types, safety scientists, pharmaceutical and equipment manufacturers, regulators, liability insurance companies, and also surgeons. Specific alerts, campaigns, discussions, and projects have targeted a host of safety issues and dangers over the years, starting with minimal intraoperative monitoring in 1986 and all the way up to beach-chair position cerebral perfusion pressure, operating room medication errors, and the extremely popular DVD on operating room fire safety in 2010; the list is long and expansive. The APSF has served as a model and inspiration for subsequent patient safety organizations and has been recognized nationally as having a dramatic positive impact on the safety of anesthesia care. Recognizing that the work is not over, that systems, organizations, and equipment still at times fail, that basic preventable human errors still do sometimes occur, and that "production pressure" in anesthesia practice threatens past safety gains, the APSF is firmly committed and continues to work hard both on established tenets and new patient safety principles. PMID:22253277

  19. Biotechnology and the Third World: Panacea or Recipe for Social Disaster? Academy for Educational Development 25th Anniversary Series.

    ERIC Educational Resources Information Center

    Morehouse, Ward

    Asserting that developmental growth is easier to attain in developing countries than social change, this paper assesses the prospective impact of biotechnology on the developing nations. Biotechnology is defined as the integrated use of biochemistry, microbiology, and chemical engineering to achieve the industrial processes of fermentation, enzyme…

  20. Education, Section J. Extracted from the 2000 New York State Statistical Yearbook. 25th Anniversary Edition. Revised and Expanded.

    ERIC Educational Resources Information Center

    State Univ. of New York, Albany. Nelson A. Rockefeller Inst. of Government.

    This yearbook presents statistical information about the state of New York and its population as well as information on the five boroughs of New York City. The 41 tables of Section J describe education in New York state in the 1990s and into 2000 and contain information that makes it possible to compare these statistics from previous years and for…

  1. A resolution celebrating February 2, 2011, as the 25th anniversary of "National Women and Girls in Sports Day".

    THOMAS, 112th Congress

    Sen. Snowe, Olympia J. [R-ME

    2011-01-27

    02/02/2011 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (text: CR S492) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  2. 25th anniversary article: Design of polymethine dyes for all-optical switching applications: guidance from theoretical and computational studies.

    PubMed

    Gieseking, Rebecca L; Mukhopadhyay, Sukrit; Risko, Chad; Marder, Seth R; Brédas, Jean-Luc

    2014-01-01

    All-optical switching--controlling light with light--has the potential to meet the ever-increasing demand for data transmission bandwidth. The development of organic π-conjugated molecular materials with the requisite properties for all-optical switching applications has long proven to be a significant challenge. However, recent advances demonstrate that polymethine dyes have the potential to meet the necessary requirements. In this review, we explore the theoretical underpinnings that guide the design of π-conjugated materials for all-optical switching applications. We underline, from a computational chemistry standpoint, the relationships among chemical structure, electronic structure, and optical properties that make polymethines such promising materials. PMID:24302357

  3. Proceedings of the 25th Annual Stirling Physics Meeting 1999

    NASA Astrophysics Data System (ADS)

    McVey, Michael

    1999-09-01

    The 25th Annual Stirling Physics meeting took place on Thursday 20 May on a warm sunny day when the country setting of Stirling Campus could be seen at its best. A total of 225 participants from all sectors of physics education attended. There was an opportunity to view and discuss with exhibitors a wide range of state-of-the-art equipment and teaching materials both before and after the meeting. The theme of the meeting was `Maintaining Standards'. Gemmel Millar, Scottish Branch Secretary acting as Chairperson for the morning session and in anticipation of the first speaker, wondered if a new unit qualification, the `Planck' might be introduced. Half units would then be `Short Plancks' and how many Short Plancks must there be in a unit? Great stuff. Scottish Qualifications Authority Hugh McGill began with a brief history and description of the Scottish Qualifications Authority. Born on 1 April 1997 (a light frisson of amusement swept through the audience) it was a unification between SEB and SCOTVEC and has a range of responsibilities covering schools, further and higher education. It oversees Standard and Higher grades, HNC and HND and SVQs, and it has 500 full-time employees as well as some 13500 appointees who act as examiners, assessors and verifiers etc, without whom its remit could not be carried out. The committee structure of the Board was outlined, one each for national and higher national qualifications and a third for Scottish vocational qualifications. These will be served by a proposed 19 Advisory Groups. The Science Advisory Group will be the key body for advising SQA on strategic developments to ensure that qualifications meet the needs of both client groups and end users. A consultation paper `Added Value To Learning' was referred to, in which all qualifications available in Scotland are given parity of esteem on a rising 11-point scale. Mr McGill stated that standards would be best maintained by ensuring continuity in procedures developed over

  4. Rejuvenation of automotive fuel cells

    DOEpatents

    Kim, Yu Seung; Langlois, David A.

    2016-08-23

    A process for rejuvenating fuel cells has been demonstrated to improve the performance of polymer exchange membrane fuel cells with platinum/ionomer electrodes. The process involves dehydrating a fuel cell and exposing at least the cathode of the fuel cell to dry gas (nitrogen, for example) at a temperature higher than the operating temperature of the fuel cell. The process may be used to prolong the operating lifetime of an automotive fuel cell.

  5. Proceedings of the 25th Annual Stirling Physics Meeting 1999

    NASA Astrophysics Data System (ADS)

    McVey, Michael

    1999-09-01

    The 25th Annual Stirling Physics meeting took place on Thursday 20 May on a warm sunny day when the country setting of Stirling Campus could be seen at its best. A total of 225 participants from all sectors of physics education attended. There was an opportunity to view and discuss with exhibitors a wide range of state-of-the-art equipment and teaching materials both before and after the meeting. The theme of the meeting was `Maintaining Standards'. Gemmel Millar, Scottish Branch Secretary acting as Chairperson for the morning session and in anticipation of the first speaker, wondered if a new unit qualification, the `Planck' might be introduced. Half units would then be `Short Plancks' and how many Short Plancks must there be in a unit? Great stuff. Scottish Qualifications Authority Hugh McGill began with a brief history and description of the Scottish Qualifications Authority. Born on 1 April 1997 (a light frisson of amusement swept through the audience) it was a unification between SEB and SCOTVEC and has a range of responsibilities covering schools, further and higher education. It oversees Standard and Higher grades, HNC and HND and SVQs, and it has 500 full-time employees as well as some 13500 appointees who act as examiners, assessors and verifiers etc, without whom its remit could not be carried out. The committee structure of the Board was outlined, one each for national and higher national qualifications and a third for Scottish vocational qualifications. These will be served by a proposed 19 Advisory Groups. The Science Advisory Group will be the key body for advising SQA on strategic developments to ensure that qualifications meet the needs of both client groups and end users. A consultation paper `Added Value To Learning' was referred to, in which all qualifications available in Scotland are given parity of esteem on a rising 11-point scale. Mr McGill stated that standards would be best maintained by ensuring continuity in procedures developed over

  6. Skin rejuvenation with intense pulsed light.

    PubMed

    Kohl, Elisabeth A; Babilas, Philipp; Landthaler, Michael

    2010-01-01

    Skin rejuvenation has developed into one of the most popular indications for laser and intense pulsed light (IPL) treatment in dermatology. During the past few years, nonablative skin rejuvenation with infrared lasers has become ever more popular. The results for hyperpigmentation, telangiectasias and erythema are very good, whereas the results in treating wrinkles are not as good as with ablative therapy. PMID:20887700

  7. Mosquito vector biology and control in Latin America - A 25th Symposium

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The 25th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 81st Annual Meeting in New Orleans, LA, in March 2015. The principal objective, for the previous 24 symposia, was to promote participation in the AMCA by vector control spec...

  8. Editorial: Special issue highlighting research presented at the 25th IWGO Conference, Chicago 2014

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A joint international conference was held among corn insect entomologists from 15 countries at the Allerton Hotel, Chicago, Illinois on April 13-17, 2014. It combined the 25th IWGO (International Working Group on Ostrinia and other maize pests) Conference with the 4th Diabrotica Genetics Conference,...

  9. REPORT FROM THE ORGANIZERS: The 25th International Conference on Low Temperature Physics

    NASA Astrophysics Data System (ADS)

    Kes, Peter

    2009-03-01

    The 25th International Conference on Low Temperature Physics (LT25) was hosted by the Kamerlingh Onnes Laboratorium of the Leiden Institute of Physics and held in the RAI Convention Center in Amsterdam, The Netherlands, 6-13 August 2008. It was the second time that the Kamerlingh Onnes Laboratory had the privilege of organizing an LT conference. In 1958, at LT6, 50 years of liquid helium temperatures were commemorated; in 2008 we celebrated the 100th anniversary of the remarkable achievements of Heike Kamerlingh Onnes and his collaborators in Leiden. In 1958 there were 323 participants and 145 papers appeared in the proceedings; in 2008 these numbers had increased to 1390 participants and 900 papers, of which eventually 849 were accepted. This large participation required adequate conference and housing facilities. These could not be found in Leiden, but were conveniently available in Amsterdam. The triennial International Low Temperature Conferences are organized under the auspices of the International Union of Pure and Applied Physics (IUPAP) through Commission C5 on Low Temperature Physics. It is the most important global meeting that brings together the international scientific community in the broad field of Low Temperature Physics. Because the meeting is held only every third year the 11 plenary and 22 half plenary talks (of 45 or 30 min.) generally provide an overview of important new discoveries over the last few years, whereas the 161 short oral presentations (20 min.) are mainly focused on very recent developments. Since the field is broad, embracing a large section of condensed matter physics, the program is divided into five parallel program lines: A. Quantum Gases, Fluids and Solids B. Superconductivity C. Quantum Phase Transitions and Magnetism D. Electronic Quantum Transport in Condensed Matter E. Cryogenic Techniques and Applications This distinction was used both to group the 1625 accepted abstracts, and the short-oral and poster presentations; the

  10. Research activities on Antarctic middle atmosphere by JARE 25th team

    NASA Technical Reports Server (NTRS)

    Hirasawa, T.; Eiwasaka, Y. AFTANAKA, M. agfujii, r.0 typ; Eiwasaka, Y. AFTANAKA, M. agfujii, r.0 typ

    1985-01-01

    The Antarctic Middle Atmosphere (AMA)-Japan research project was set about by the JARE (Japan Antarctic Research Expedition) 23rd team in 1982, and since then the JARE-24th and JARE-25th teams have been continuing reseach on the Antarctic Middle Atmosphere. Results gained by JARE-25th team members who are now working at Syowa Station (69.99 deg S, 39.35 deg E), Antarctica are presented. In their activities satellite measurements (Exos-C) and rocket soundings are used. Three rockets of the S310 type were launched at Syowa Station (Geomagnetic Latitude = 69.9 deg S) for the purpose of directly observing the electron density, ionospheric temperature, auroral patterns and luminosity in situ. Vertical profiles of electron density and auroral emission 4278A measured by three rockets are compared.

  11. Niacin: an old drug rejuvenated.

    PubMed

    Kamanna, Vaijinath S; Ganji, Shobha H; Kashyap, Moti L

    2009-01-01

    Niacin has long been used in the treatment of dyslipidemia and cardiovascular disease. Recent research on niacin has been focused on understanding the mechanism of action of niacin and preparation of safer niacin formulations. New findings indicate that niacin does the following: 1) it inhibits hepatic diacylglycerol acyltransferase 2, resulting in inhibition of triglyceride synthesis and decreased apolipoprotein B-containing lipoproteins; 2) it decreases the surface expression of hepatic adenosine triphosphate synthase beta-chain, leading to decreased holoparticle high-density lipoprotein catabolism and increased high-density lipoprotein levels; and 3) it increases redox potential in arterial endothelial cells, resulting in inhibition of redox-sensitive genes. Flushing, an adverse effect of niacin, results from niacin receptor GPR109A-mediated production of prostaglandin D2 and E2 via DP1 and EP2/4 receptors. DP1 receptor antagonist (laropiprant) attenuates the niacin flush. A reformulated preparation of extended-release niacin (Niaspan; Abbott, Abbott Park, IL) lowers flushing compared with an older Niaspan formulation. These advancements in niacin research have rejuvenated its use for the treatment of dyslipidemia and cardiovascular disease. PMID:19080727

  12. Mitochondrial Rejuvenation After Induced Pluripotency

    PubMed Central

    Tjong, Jonathan; Alcasid, Nathan; Perkins, Guy A.; Goissis, Marcelo D.; Ellisman, Mark H.; Perez, Gloria I.; Cibelli, Jose B.

    2010-01-01

    Background As stem cells of the early embryo mature and differentiate into all tissues, the mitochondrial complement undergoes dramatic functional improvement. Mitochondrial activity is low to minimize generation of DNA-damaging reactive oxygen species during pre-implantation development and increases following implantation and differentiation to meet higher metabolic demands. It has recently been reported that when the stem cell type known as induced pluripotent stem cells (IPSCs) are re-differentiated for several weeks in vitro, the mitochondrial complement progressively re-acquires properties approximating input fibroblasts, suggesting that despite the observation that IPSC conversion “resets” some parameters of cellular aging such as telomere length, it may have little impact on other age-affected cellular systems such as mitochondria in IPSC-derived cells. Methodology/Principal Findings We have examined the properties of mitochondria in two fibroblast lines, corresponding IPSCs, and fibroblasts re-derived from IPSCs using biochemical methods and electron microscopy, and found a dramatic improvement in the quality and function of the mitochondrial complement of the re-derived fibroblasts compared to input fibroblasts. This observation likely stems from two aspects of our experimental design: 1) that the input cell lines used were of advanced cellular age and contained an inefficient mitochondrial complement, and 2) the re-derived fibroblasts were produced using an extensive differentiation regimen that may more closely mimic the degree of growth and maturation found in a developing mammal. Conclusions/Significance These results — coupled with earlier data from our laboratory — suggest that IPSC conversion not only resets the “biological clock”, but can also rejuvenate the energetic capacity of derived cells. PMID:21124794

  13. REPORT FROM THE ORGANIZERS: The 25th International Conference on Low Temperature Physics

    NASA Astrophysics Data System (ADS)

    Kes, Peter

    2009-03-01

    The 25th International Conference on Low Temperature Physics (LT25) was hosted by the Kamerlingh Onnes Laboratorium of the Leiden Institute of Physics and held in the RAI Convention Center in Amsterdam, The Netherlands, 6-13 August 2008. It was the second time that the Kamerlingh Onnes Laboratory had the privilege of organizing an LT conference. In 1958, at LT6, 50 years of liquid helium temperatures were commemorated; in 2008 we celebrated the 100th anniversary of the remarkable achievements of Heike Kamerlingh Onnes and his collaborators in Leiden. In 1958 there were 323 participants and 145 papers appeared in the proceedings; in 2008 these numbers had increased to 1390 participants and 900 papers, of which eventually 849 were accepted. This large participation required adequate conference and housing facilities. These could not be found in Leiden, but were conveniently available in Amsterdam. The triennial International Low Temperature Conferences are organized under the auspices of the International Union of Pure and Applied Physics (IUPAP) through Commission C5 on Low Temperature Physics. It is the most important global meeting that brings together the international scientific community in the broad field of Low Temperature Physics. Because the meeting is held only every third year the 11 plenary and 22 half plenary talks (of 45 or 30 min.) generally provide an overview of important new discoveries over the last few years, whereas the 161 short oral presentations (20 min.) are mainly focused on very recent developments. Since the field is broad, embracing a large section of condensed matter physics, the program is divided into five parallel program lines: A. Quantum Gases, Fluids and Solids B. Superconductivity C. Quantum Phase Transitions and Magnetism D. Electronic Quantum Transport in Condensed Matter E. Cryogenic Techniques and Applications This distinction was used both to group the 1625 accepted abstracts, and the short-oral and poster presentations; the

  14. [Friedrich Nietzsche: history of his illness. On the 100th anniversary of the death of the poet-philosopher].

    PubMed

    Wilkes, J

    2000-04-01

    The philosopher Friedrich Nietzsche was one of the most famous patients in the psychiatric hospital Jena. Between 1889 and 1890, Otto Binswanger und Theodor Ziehen treated the progressive paralysis of Friedrich Nietzsche whose 100th anniversary of death is on 25th August 2000. After Nietzsche's death, an animated discussion about his disease arose. Many objected against the syphilitic diagnosis of the disease. Nietzsche's medical fill became a popular object of science, although it ended as a very odd story. PMID:10812640

  15. Exceptional Volumes of Rejuvenated Volcanism in Samoa

    NASA Astrophysics Data System (ADS)

    Konter, J. G.; Jackson, M.; Storm, L.

    2010-12-01

    The internal structure of within-plate volcanoes is typically compared to the stages of volcanic evolution in Hawaii. In Samoa, these stages show some differences with the Hawaiian model, in terms of the duration, volume and geochemical composition of the stages. Particularly, the rejuvenated stage of volcanism in Samoa is significantly more voluminous, with increasing geographic coverage with age, completely repaving the island of Savai’i. This unusual outpouring of rejuvenated lavas has previously been proposed to be related to the tectonic setting, near the northern terminus of the Tonga Trench. Therefore, Samoan volcanism might be caused by lithospheric fracturing, a mantle plume, or potentially a combination of the two. We collected new samples from a deeply eroded canyon on Savai’i to determine a time evolution of the transition from shield to eventual rejuvenated lavas. The canyon exposes several hundred meters of lavas, and we collected samples about 200m vertically down into the canyon. These samples are dominantly olivine basalts, and their Pb isotope compositions fall within the compositional field of young rejuvenated lavas on Savai’i and Upolu. This canyon section, therefore, represents a minimum thickness for the rejuvenated lavas of 200m. Assuming eruption of rejuvenated lavas only occurred subaerially, with a universal thickness of 200m, the new data suggest more than one percent of the volume of Savai’i consists of rejuvenated lavas. This is an order of magnitude greater than the largest relative volumes in Hawaii (Kauai), and implies a different cause for rejuvenated volcanism in Samoa. Another feature that suggests different processes may be important is the transition between the shield and rejuvenated stage. Although Samoan volcanoes do not seem to erupt exactly the same rock types as characteristic Hawaiian post-shield stage lavas, there is a definite shift to more evolved compositions (including trachytes) during the later stages of

  16. Predictions of the onset of mini ice age in the 25th solar cycle

    NASA Astrophysics Data System (ADS)

    Kumar, Rajiv

    2016-07-01

    Predictions of the ir-regularty in the 11 year heartbeat of the sun due to asyncronous of the two layered dynamo effect would result in mini ice age as in the Maunder minimum.The onset of this event is expected in the begining of 25th solar cycle and would go to its maximum in the 26th solar cycle.The minimum temperature is expected in 2028 due to the fall of solar activity by 60 % termed as solar hibernation.The predictions are based on the observations obtained by the Royal Greenwich observatory since 1874. Keywords: Dynamo effect,munder minimum,Solar hybernation

  17. Aging and brain rejuvenation as systemic events

    PubMed Central

    Bouchard, Jill; Villeda, Saul A

    2015-01-01

    The effects of aging were traditionally thought to be immutable, particularly evident in the loss of plasticity and cognitive abilities occurring in the aged central nervous system (CNS). However, it is becoming increasingly apparent that extrinsic systemic manipulations such as exercise, caloric restriction, and changing blood composition by heterochronic parabiosis or young plasma administration can partially counteract this age-related loss of plasticity in the aged brain. In this review, we discuss the process of aging and rejuvenation as systemic events. We summarize genetic studies that demonstrate a surprising level of malleability in organismal lifespan, and highlight the potential for systemic manipulations to functionally reverse the effects of aging in the CNS. Based on mounting evidence, we propose that rejuvenating effects of systemic manipulations are mediated, in part, by blood-borne ‘pro-youthful’ factors. Thus, systemic manipulations promoting a younger blood composition provide effective strategies to rejuvenate the aged brain. As a consequence, we can now consider reactivating latent plasticity dormant in the aged CNS as a means to rejuvenate regenerative, synaptic, and cognitive functions late in life, with potential implications even for extending lifespan. PMID:25327899

  18. Mosquito Vector Biology and Control in Latin America-A 25TH Symposium.

    PubMed

    2015-09-01

    The 25th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 81st Annual Meeting in New Orleans, LA, in March 2015. The principal objective, as for the previous 24 symposia, was to promote participation in the AMCA by vector control specialists, public health workers, and academicians from Latin America. This publication includes summaries of 24 presentations that were given orally in Spanish by participants from Colombia, Mexico, and the USA. Topics addressed in the symposium included: surveillance, operations, ecology, chemical control, studies of dengue viruses, and insecticide resistance. Insect vectors included Aedes, Culex, and Anopheles mosquitoes in addition to phlebotomine sand flies and triatomine bugs. PMID:26375913

  19. The Daylight Bolide of 1996 April 25th , over Mt. Bruce, New Zealand

    NASA Astrophysics Data System (ADS)

    Wolf, G.; McBeath, A.

    On Thursday, 1996 April 25th (ANZAC Day in New Zealand) a bright daylight bolide with possible -22m end point, was seen from Newtown, Wellington, New Zealand at 02h20m12s. Its end-point altitude was calculated to be app. 15-20km over Mt. Bruce, some 80km NE of Wellington. A smoky train, initially 42deg long, was visible to the naked eye for 28 minutes afterwards. Sonics were heard by the New Zealand author, around 265s after the end point, suggesting a direct-line distance of 88km from the author's location. The impact point was probably several kilometers off Foxton Beach in the Tasman Sea. The bolide passed about 5deg above the first quarter Moon, and two photographs were secured, showing how the train began to drift, ultimately app. 17deg, to the south, before dissipating.

  20. A single injection technique for midface rejuvenation.

    PubMed

    Cattin, Teresa A

    2010-09-01

    The correction of volume loss has become an important part of facial rejuvenation treatments, particularly in the midface region. Techniques to date have largely relied on multiple injections, fanning techniques and deep placement of product under muscle or on periosteum. This article describes a new technique to enhance volume in the midface using a single injection of cross-linked hyaluronic acid at the subdermal level and above the muscle. The technique approaches midface rejuvenation with reference to both the bony skeleton and the medial malar fat compartment. After appropriately marking the skin, the filler is placed using a blunt cannula. The treatment achieves satisfactory volume correction, enhancing the sharp cheek bones and malar fullness typical of an attractive adult face. The approach is simple, quick, and well tolerated by the patient and may result in less bruising than deeper techniques. PMID:20883303

  1. Structural rejuvenation in bulk metallic glasses

    DOE PAGESBeta

    Tong, Yang; Iwashita, T.; Dmowski, Wojciech; Bei, Hongbin; Yokoyama, Y.; Egami, Takeshi

    2015-01-05

    Using high-energy X-ray diffraction we study structural changes in bulk metallic glasses after uniaxial compressive homogeneous deformation at temperatures slightly below the glass transition. We observe that deformation results in structural disordering corresponding to an increase in the fictive, or effective, temperature. However, the structural disordering saturates after yielding. Lastly, examination of the experimental structure and molecular dynamics simulation suggests that local changes in the atomic connectivity network are the main driving force of the structural rejuvenation.

  2. Impact on facial rejuvenation with dermatological preparations

    PubMed Central

    Bowler, Patrick J

    2009-01-01

    The treatment options for facial rejuvenation using dermatological, nonsurgical techniques have dramatically increased in the past 10 years. This follows the introduction of botulinum toxin and a variety of dermal fillers. The public interest in noninvasive treatments has changed the market beyond recognition with more physicians involved in providing services to satiate the demand. The impact on the public and medical profession is discussed. PMID:19503770

  3. A Software Rejuvenation Framework for Distributed Computing

    NASA Technical Reports Server (NTRS)

    Chau, Savio

    2009-01-01

    A performability-oriented conceptual framework for software rejuvenation has been constructed as a means of increasing levels of reliability and performance in distributed stateful computing. As used here, performability-oriented signifies that the construction of the framework is guided by the concept of analyzing the ability of a given computing system to deliver services with gracefully degradable performance. The framework is especially intended to support applications that involve stateful replicas of server computers.

  4. Rejuvenation: an integrated approach to regenerative medicine.

    PubMed

    Kang, Y James; Zheng, Lily

    2013-12-01

    The word "rejuvenate" found in the Merriam-Webster dictionary is (1) to make young or youthful again: give new vigor to, and (2) to restore to an original or new state. Regenerative medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects. To accomplish this, approaches including transplantation, tissue engineering, cell therapy, and gene therapy are brought into action. These all use exogenously prepared materials to forcefully mend the failed organ. The adaptation of the materials in the host and their integration into the organ are all uncertain. It is a common sense that tissue injury in the younger is easily repaired and the acute injury is healed better and faster. Why does the elder have a diminished capacity of self-repairing, or why does chronic injury cause the loss of the self-repairing capacity? There must be some critical elements that are involved in the repair process, but are suppressed in the elder or under the chronic injury condition. Rejuvenation of the self-repair mechanism would be an ideal solution for functional recovery of the failed organ. To achieve this, it would involve renewal of the injury signaling, reestablishment of the communication and transportation system, recruitment of the materials for repairing, regeneration of the failed organ, and rehabilitation of the renewed organ. It thus would require a comprehensive understanding of developmental biology and a development of new approaches to activate the critical players to rejuvenate the self-repair mechanism in the elder or under chronic injury condition. Efforts focusing on rejuvenation would expect an alternative, if not a better, accomplishment in the regenerative medicine. PMID:25984326

  5. "25 Years of Educational Excellence." Special Issue Commemorating the 25th Anniversary of the Journal of the Pennsylvania Black Conference on Higher Education, Inc.

    ERIC Educational Resources Information Center

    Redfern, Alicia King, Ed.

    1996-01-01

    The articles in this document are intended to be reflective of the theme "A Silver Celebration: 25 Years of Educational Excellence," and cover topics ranging from black college athletes to black real estate owners to the status of African Americans in Pennsylvania colleges and universities. They include: "The Social and Political Dimensions of…

  6. 25th anniversary article: what can be done with the Langmuir-Blodgett method? Recent developments and its critical role in materials science.

    PubMed

    Ariga, Katsuhiko; Yamauchi, Yusuke; Mori, Taizo; Hill, Jonathan P

    2013-12-01

    The Langmuir-Blodgett (LB) technique is known as an elegant method for fabrication of well-defined layered structures with molecular level precision. Since its discovery the LB method has made an indispensable contribution to surface science, physical chemistry, materials chemistry and nanotechnology. However, recent trends in research might suggest the decline of the LB method as alternate methods for film fabrication such as layer-by-layer (LbL) assembly have emerged. Is LB film technology obsolete? This review is presented in order to challenge this preposterous question. In this review, we summarize recent research on LB and related methods including (i) advanced design for LB films, (ii) LB film as a medium for supramolecular chemistry, (iii) LB technique for nanofabrication and (iv) LB involving advanced nanomaterials. Finally, a comparison between LB and LbL techniques is made. The latter reveals the crucial role played by LB techniques in basic surface science, current advanced material sciences and nanotechnologies. PMID:24302266

  7. The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters

    PubMed Central

    Golin, John; Ambudkar, Suresh V.

    2016-01-01

    Asymmetric ABC (ATP-binding cassette) transporters make up a significant proportion of this important superfamily of integral membrane proteins. These proteins contain one canonical (catalytic) ATP-binding site and a second atypical site with little enzymatic capability. The baker’s yeast (Saccharomyces cerevisiae) Pdr5 multidrug transporter is the founding member of the Pdr subfamily of asymmetric ABC transporters, which exist only in fungi and slime moulds. Because these organisms are of considerable medical and agricultural significance, Pdr5 has been studied extensively, as has its medically important homologue Cdr1 from Candida albicans. Genetic and biochemical analyses of Pdr5 have contributed important observations that are likely to be applicable to mammalian asymmetric ABC multidrug transporter proteins, including the basis of transporter promiscuity, the function of the non-catalytic deviant ATP-binding site, the most complete description of an in vivo transmission interface, and the recent discovery that Pdr5 is a molecular diode (one-way gate). In the present review, we discuss the observations made with Pdr5 and compare them with findings from clinically important asymmetric ABC transporters, such as CFTR (cystic fibrosis transmembrane conductance regulator), Cdr1 and Tap1/Tap2. PMID:25886173

  8. Honoring the 25th anniversary of the enactment of the Drug Price Competition and Patent Term Restoration Act of 1984 (the Hatch-Waxman Act).

    THOMAS, 111th Congress

    Sen. Brown, Sherrod [D-OH

    2009-09-24

    09/24/2009 Referred to the Committee on the Judiciary. (text of measure as introduced: CR S9853) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  9. SPECIAL ISSUE DEVOTED TO THE 25th ANNIVERSARY OF THE A.M. PROKHOROV GENERAL PHYSICS INSTITUTE: Femtosecond laser optical gas breakdown microplasma: the ionisation and postionisation dynamics

    NASA Astrophysics Data System (ADS)

    Bukin, V. V.; Garnov, S. V.; Malyutin, A. A.; Strelkov, V. V.

    2007-10-01

    The formation and evolution dynamics of the laser plasma produced in the microvolumes of gases (air, nitrogen, argon, and helium) upon their multiple ionisation by high-intensity (4×1016 W cm-2) tightly focused (to a region 1.7 μm in diameter) 400-nm, 100-fs second-harmonic pulses from a Ti:sapphire laser is studied. The spatiotemporal distribution profiles of the refractive index and electron microplasma density were recorded by ultrahigh-speed interferometry. The postionisation of a femtosecond laser plasma, i.e. the growth of the electron density known after the end of the exciting laser pulse, is detected for the first time. A theoretical model is proposed, which describes the mechanism of plasma postionisation by hot photoelectrons. The results of electron density calculations are in good agreement with experimental data.

  10. The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters.

    PubMed

    Golin, John; Ambudkar, Suresh V

    2015-05-01

    Asymmetric ABC (ATP-binding cassette) transporters make up a significant proportion of this important superfamily of integral membrane proteins. These proteins contain one canonical (catalytic) ATP-binding site and a second atypical site with little enzymatic capability. The baker's yeast (Saccharomyces cerevisiae) Pdr5 multidrug transporter is the founding member of the Pdr subfamily of asymmetric ABC transporters, which exist only in fungi and slime moulds. Because these organisms are of considerable medical and agricultural significance, Pdr5 has been studied extensively, as has its medically important homologue Cdr1 from Candida albicans. Genetic and biochemical analyses of Pdr5 have contributed important observations that are likely to be applicable to mammalian asymmetric ABC multidrug transporter proteins, including the basis of transporter promiscuity, the function of the non-catalytic deviant ATP-binding site, the most complete description of an in vivo transmission interface, and the recent discovery that Pdr5 is a molecular diode (one-way gate). In the present review, we discuss the observations made with Pdr5 and compare them with findings from clinically important asymmetric ABC transporters, such as CFTR (cystic fibrosis transmembrane conductance regulator), Cdr1 and Tap1/Tap2. PMID:25886173

  11. Teaching Biochemistry at Lisbon University--Facing the Challenge of the Bologna Declaration in the 25th Anniversary of the Biochemistry Course

    ERIC Educational Resources Information Center

    Farinha, Carlos M.; Freire, Ana Ponces

    2007-01-01

    The biochemistry degree has been taught at Lisbon University for 25 years. Since its creation, the curriculum is characterized for being widely eclectic and multidisciplinary. The adoption of the concepts proposed in Europe by the Declaration of Bologna and incorporation of these ideas at Lisbon University is discussed here for the biochemistry…

  12. Land Processes Distributed Active Archive Center (LP DAAC) 25th Anniversary Recognition "A Model for Government Partnerships". LP DAAC "History and a Look Forward"

    NASA Technical Reports Server (NTRS)

    Behnke, Jeanne; Doescher, Chris

    2015-01-01

    This presentation discusses 25 years of interactions between NASA and the USGS to manage a Land Processes Distributed Active Archive Center (LPDAAC) for the purpose of providing users access to NASA's rich collection of Earth Science data. The presentation addresses challenges, efforts and metrics on the performance.

  13. 11th Annual LVMH Recherche Symposium: skin rejuvenation.

    PubMed

    Bonté, Frédéric

    2012-01-01

    The 11(th) Annual LVMH Recherche Scientific Symposium was held in London on October 27(th), into the warmth of the distinguished British Library, with nearly 150 industry and research attendees. The meeting organized by LVMH Recherche was centered on the theme of skin rejuvenation. The current state of play for rejuvenation research was summarized, and then advances in the science of skin aging and rejuvenation therapies were discussed in detail. Personalized genomics and current and prospective translational therapies were presented, followed by a clever linking of multiple global theories towards a cohesive plan for future goals in rejuvenation research. PMID:22615002

  14. Proceedings of the 25th Seismic Research Review -- Nuclear Explosion Monitoring: Building the Knowledge Base

    SciTech Connect

    Chavez, Francesca C.; Mendius, E. Louise

    2003-09-23

    These proceedings contain papers prepared for the 25th Seismic Research Review -- Nuclear Explosion Monitoring: Building the Knowledge Base, held 23-25 September, 2003 in Tucson, Arizona. These papers represent the combined research related to ground-based nuclear explosion monitoring funded by the National Nuclear Security Administration (NNSA), Defense Threat Reduction Agency (DTRA), Air Force Research Laboratory (AFRL), US Army Space and Missile Defense Command, and other invited sponsors. The scientific objectives of the research are to improve the United States capability to detect, locate, and identify nuclear explosions. The purpose of the meeting is to provide the sponsoring agencies, as well as potential users, an opportunity to review research accomplished during the preceding year and to discuss areas of investigation for the coming year. For the researchers, it provides a forum for the exchange of scientific information toward achieving program goals, and an opportunity to discuss results and future plans. Paper topics include: seismic regionalization and calibration; detection and location of sources; wave propagation from source to receiver; the nature of seismic sources, including mining practices; hydroacoustic, infrasound, and radionuclide methods; on-site inspection; and data processing.

  15. The extended SMAS approach to neck rejuvenation.

    PubMed

    Perkins, Stephen W; Waters, Heather H

    2014-05-01

    Jowling, submental lipoptosis, and platysmal banding can affect self-image and reduce quality of life, leading one to seek facial and neck rejuvenation. With realistic expectations, a facelift can provide the desired improvement in appearance and sense of well-being. Before any intervention, a detailed history, focused examination, communication of expected outcomes with the assistance of preoperative digital imaging, and discussion of perioperative instructions are of utmost importance. Although many techniques exist, the modified deep plane extended superficial muscular aponeurotic system rhytidectomy with submentoplasty reliably delivers a significant improvement with lasting results. PMID:24745387

  16. Partial rejuvenation of a colloidal glass.

    PubMed

    Ozon, F; Narita, T; Knaebel, A; Debrégeas, G; Hébraud, P; Munch, J-P

    2003-09-01

    We study the effect of shear on the aging dynamics of a colloidal suspension of synthetic clay particles. We find that a shear of amplitude gamma reduces the relaxation time measured just after the cessation of shear by a factor exp(-gamma/gamma(c)), with gamma(c) approximately 5%, and is independent of the duration and the frequency of the shear. This simple law for the rejuvenation effect shows that the energy involved in colloidal rearrangements is proportional to the shear amplitude gamma rather than gamma(2), leading to an Eyring-like description of the dynamics of our system. PMID:14524814

  17. Noninvasive Facial Rejuvenation. Part 1: Patient-Directed.

    PubMed

    Commander, Sarah Jane; Chang, Daniel; Fakhro, Abdulla; Nigro, Marjory G; Lee, Edward I

    2016-08-01

    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin and rejuvenate damaged skin. Physicians may recommend and often prescribe certain products, but the patients are in control of this type of facial rejuvenation. On the other hand, physician-directed facial rejuvenation entails modalities that require direct physician involvement, such as neuromodulators, filler injections, laser resurfacing, microdermabrasion, and chemical peels. With the successful integration of each of these modalities, a complete facial regimen can be established and patient satisfaction can be maximized. This article is the first in a three-part series describing noninvasive facial rejuvenation. The authors focus on patient-directed facial rejuvenation. It is important, however, to emphasize that even in a patient-directed modality, a physician's involvement through education and guidance is integral to its success. PMID:27478421

  18. PREFACE: 25th International Congress on Condition Monitoring and Diagnostic Engineering (COMADEM 2012)

    NASA Astrophysics Data System (ADS)

    Ball, Andrew; Mishra, Rakesh; Gu, Fengshou; Rao, Raj B. K. N.

    2012-05-01

    The proactive multidisciplinary conceptual philosophy of Condition Monitoring and Diagnostic Engineering Management (COMADEM) was conceived and has been nurtured, developed and sustained since 1988. Since then, it is gratifying to note that the condition monitoring, diagnostic and prognostic community worldwide (representing industrialists, academics, research and development organizations, professional/private establishments and many hardware/software vending organizations) has warmly welcomed and supported this venture. As is evidenced, many have reaped (and are reaping) the benefits of COMADEM interdiscipline through continuous knowledge discovery, generation and dissemination. We are now proud to celebrate the 25th Annual Event (Silver Jubilee) in Huddersfield, the most beautiful part of the United Kingdom. The theme of this Congress is 'Sustained Prosperity through Proactive Monitoring, Diagnosis, Prognosis and Management'. This proceedings is enriched by contributions from many keynote experts representing many industry and academic establishments worldwide. Authors from more than 30 different countries have pooled their rich multidisciplinary up-to-date knowledge, in order to share their invaluable experience with the COMADEM community. In this proceedings, the readers will find more than 120 refereed papers encompassing a number of topical areas of interest relating to the theme of the congress. The proceedings of COMADEM 2012 will appear in the Open Access Journal of Physics: Conference Series (JPCS), which is part of the IOP Conference Series. All papers published in the IOP Conference Series are fully citable and upon publication will be free to download. We would like to express our deep gratitude to all the keynote speakers, authors, referees, exhibitors, Technical Co-Sponsoring Organizations, Gold Sponsors, IOP Publishers, COMADEM 2012 organizing committee members, delegates and many others on whom the success of this prestigious event depends

  19. Facial rejuvenation and light: our personal experience.

    PubMed

    Trelles, Mario A; Mordon, Serge; Calderhead, R Glen

    2007-06-01

    The treatment of ageing skin remains a very hot topic, and many systems have been reported as having varying degrees of success. Nonablative lasers were developed to avoid the problematic and uncomfortable sequelae following laser ablative resurfacing, and while there was no downtime, there was also poor patient satisfaction. The same was true of the intense pulsed light systems. The use of different modalities in various combinations was found to offer much better results, however, such as a 595-nm pulsed dye laser followed by a 1,450-nm diode laser, and so on, all used at subablative thresholds. The recent entry of blue and infrared tunable plasma light and light-emitting diodes into the skin rejuvenation arena has attracted a great deal of attention. The authors suggest that no single modality can accomplish all the complex events required for effective skin rejuvenation, suggest that combination phototherapy is the best approach combined with an adjunctive epidermal care regimen, and demonstrate their development of this methodology. PMID:17122954

  20. [Progresses in therapeutic strategies for thymic rejuvenation].

    PubMed

    Tan, Jian-Xin; Wang, Ya-Jun; Zhu, Xi-Ke

    2016-02-25

    The thymus is a vital primary lymphoid organ that provides unique microenvironments for the proliferation, differentiation, and maturation of T cells. With advancing age, however, the thymus gradually undergoes age-related involution and reduction in immune function, which are characterized by decreases in tissue size, cellularity, and naïve T cell output. This dynamic process leads to the reduced efficacy of the immune system with age and contributes to the increased susceptibility to infection, autoimmune disease, and cancer. In addition, bone marrow transplantation, radio-chemotherapy and virus infection also impair the thymus and give rise to the decline in immune function. Therefore, understanding the molecular mechanisms involved in age-related thymic involution and development of novel therapeutic strategies for thymic rejuvenation have gained considerable interests in recent years. This review emphasizes thymic microenvironments and thymocyte-stromal cell interactions and summarizes our current knowledge about thymic rejuvenation in terms of sex steroid, cytokines, growth factors, hormones, transcription factors, cell graft, and microRNAs. At the end of each discussion, we also highlight unanswered issues and describe possible future research directions. PMID:26915325

  1. TRMM 3-Year Anniversary

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Ever wonder about the rain? Beyond the practicality of needing an umbrella, climate researchers have wondered about the science of rainfall for a long time. But it's only in the past few years that they've begun to roll back some of its secrets. One of their tools for doing so is a powerful satellite called the Tropical Rainfall Measuring Mission, or TRMM. Now, after three years of continual operation, project scientists have released dramatic new maps of rainfall patterns gathered across a wide band of the Earth. And with measurements from one of the satellite's advanced sensors, meteorologists are now able to calibrate ground-based rain monitoring systems with greater precision than ever before. A complete accounting of the world's total rainfall has long been a major goal of climate researchers. Rain acts as the atmosphere's fundamental engine for heat exchange; every time a raindrop falls, the atmosphere gets churned up and latent heat flows back into the total climate system. Considering that rainfall is the primary driving force of heat in the atmosphere, and that two thirds of all rain falls in the tropics, these measurements are significant for our understanding of overall climate. The above image shows a one month average of rainfall measurements taken by the TRMM's unique precipitation radar during January of 1998. Areas of low rainfall are colored light blue, while regions with heavy rainfal are colored orange and red. TRMM began collecting data in December of 1997, and continues today. For more information about TRMM's 3-year anniversary, read Maps of Falling Water To learn more about the TRMM mission or order TRMM data, see the TRMM Home Page. Image courtesy TRMM Science team and the NASA GSFC Scientific Visualization Studio.

  2. Earthquake Forecasts for Gorkha Immediately Following the 25th April, M=7.8 Mainshock

    NASA Astrophysics Data System (ADS)

    Segkou, M.; Parsons, T.

    2015-12-01

    The M-7.8 Gorkha (Nepal) earthquake on the 25th April, 2015 has shaken the central Himalayan front and immediately raised concerns for the severity of future triggered earthquakes. Here, we implement standard and innovative forecast models to predict the spatio-temporal distribution of triggered events. Key challenges addressed are: 1) the limited information on early aftershocks, 2) the low-productivity aftershock sequence in the near-source area, 3) the off-fault (>250 km) triggered events exemplified by the M=5.4 Xegar event, 3 hrs after the mainshock. We apply short-term empirical/statistical ETAS and physical forecast models, the latter based on the combination of rate/state friction law and Coulomb stresses. Within the physics-based model implementation we seek to evaluate the uncertainty related with the rupture style of triggered events by considering: 1) the geometry of active structures, 2) optimally oriented for failure faults and 3) all-potential faults described by the total stress field. The latter is represented by the full stress tensor before and after the mainshock and our analysis suggests that the preseismic stress magnitudes are still sufficient to cause earthquakes even after modification by the mainshock. The above remark reveals that there are no "stress shadows" affecting the spatial distribution of near-field aftershocks. It is also noted that the method allows for an a-priori determination of the rupture plan of the M=7.3 event, within the limit of uncertainty (20˚). The results show that: (1) ETAS models underestimate the number of observed events, since they heavily base their good performance in small magnitude earthquakes, not available in the first few weeks after the mainshock, (2) far field triggered events are captured only by physics-based forecasts, and (3) the total stress method improves the predictability of larger magnitude events. We conclude that frontier regions benefit from the implementation of physics-based models

  3. Galvanostatic Ion Detrapping Rejuvenates Oxide Thin Films.

    PubMed

    Arvizu, Miguel A; Wen, Rui-Tao; Primetzhofer, Daniel; Klemberg-Sapieha, Jolanta E; Martinu, Ludvik; Niklasson, Gunnar A; Granqvist, Claes G

    2015-12-01

    Ion trapping under charge insertion-extraction is well-known to degrade the electrochemical performance of oxides. Galvanostatic treatment was recently shown capable to rejuvenate the oxide, but the detailed mechanism remained uncertain. Here we report on amorphous electrochromic (EC) WO3 thin films prepared by sputtering and electrochemically cycled in a lithium-containing electrolyte under conditions leading to severe loss of charge exchange capacity and optical modulation span. Time-of-flight elastic recoil detection analysis (ToF-ERDA) documented pronounced Li(+) trapping associated with the degradation of the EC properties and, importantly, that Li(+) detrapping, caused by a weak constant current drawn through the film for some time, could recover the original EC performance. Thus, ToF-ERDA provided direct and unambiguous evidence for Li(+) detrapping. PMID:26599729

  4. Forever young: rejuvenating muscle satellite cells

    PubMed Central

    Madaro, Luca; Latella, Lucia

    2015-01-01

    A hallmark of aging is alteration of organismal homeostasis and progressive decline of tissue functions. Alterations of both cell intrinsic functions and regenerative environmental cues contribute to the compromised stem cell activity and reduced regenerative capability occurring in aged muscles. In this perspective, we discuss the new evidence supporting the hypothesis that skeletal muscle stem cells (MuSCs) are intrinsically defective in elderly muscles. In particular, we review three recent papers leading to identify fibroblast growth factor receptor-1, p38 mitogen-activated protein kinase, and p16INK4a as altered signaling in satellite cells from aged mice. These pathways contribute to age-related loss of MuSCs asymmetric polarization, compromised self-renewal capacity, and acquisition of pre-senescent state. The pharmacological manipulation of those networks can open novel strategies to rejuvenate MuSCs and counteract the functional decline of skeletal muscle during aging. PMID:25954192

  5. The neural rejuvenation hypothesis of cocaine addiction.

    PubMed

    Dong, Yan; Nestler, Eric J

    2014-08-01

    A leading hypothesis guiding current molecular and cellular research into drug addiction conceptualizes key aspects of addiction as a form of memory in which common neuroplasticity mechanisms that mediate normal learning and memory processes are 'hijacked' by exposure to drugs of abuse to produce pathologic addiction-related memories. Such addiction-related memories are particularly robust and long-lasting and once formed are less amenable to updating. Here we propose a neural rejuvenation hypothesis of cocaine addiction. According to this hypothesis, repeated exposure to drugs of abuse induces some plasticity mechanisms normally associated with brain development within the reward circuitry that mediate the highly efficient and unusually stable memory abnormalities that characterize addiction. PMID:24958329

  6. The Neural Rejuvenation Hypothesis of Cocaine Addiction

    PubMed Central

    Dong, Yan; Nestler, Eric J.

    2014-01-01

    A leading hypothesis guiding current molecular and cellular research of drug addiction conceptualizes key aspects of addiction as a form of memory, in which common neuroplasticity mechanisms that mediate normal learning and memory processes are “hijacked” by exposure to drugs of abuse to produce pathologic addiction-related memories. Such addiction-related memories are particularly robust and long-lasting and once formed, less amenable to updating. Here, we propose the Neural Rejuvenation Hypothesis of Cocaine Addiction: that repeated exposure to drugs of abuse induces some plasticity mechanisms that are normally associated with brain development within the brain’s reward circuitry, which mediate the highly efficient and unusually stable memory abnormalities that characterize addiction. PMID:24958329

  7. Stockpile Stewardship's 20th Anniversary

    SciTech Connect

    Hecker, Siegfried; Gottemoeller, Rose; Reis, Victor H.; McMillan, Charles; Rohlfing, Joan; Hurricane, Omar; Hagengruber, Roger; Taylor, John

    2015-10-22

    A short oral history of the NNSA's Stockpile Stewardship Program, produced in association with the 20th anniversary of the program. It features Siegfried Hecker, Rose Gottemoeller, Victor Reis, Charles McMillan, Joan Rohlfing, Omar Hurricane, Roger Hagengruber, and John Taylor.

  8. A Gradual Compositional Change from Samoan Shield to Rejuvenated Lavas?

    NASA Astrophysics Data System (ADS)

    Konter, J. G.; Jackson, M. G.; Koppers, A. A.

    2013-12-01

    The geochemical evolution of intraplate volcanoes is often compared to the archetypal model derived from Hawaiian volcanoes that involves a mantle plume source with multiple components. In Samoa, a range in rock types, ages, and isotopic compositions have been obtained across a number of volcanic seamounts and islands. However, due to dense vegetation on the islands, stratigraphic relations are not well known, and therefore a sequence for the construction of Samoan volcanoes is not as well-defined as in Hawaii. On the three largest islands, a shield and a rejuvenated stage have been defined, whereas the existence of a post-shield stage has been suggested and questioned (Natland and Turner, 1985). Moreover, the existing shield isotopic compositions (particularly Sr) are distinct, spanning a larger range than in Hawaii. Tutuila only hosts a small amount of rejuvenated lavas, but they are similar to those of Upolu, and there is an isotopic and compositional overlap between Tutuila shield volcanics and the Upolu lavas. On the island of Upolu, roughly half the surface area is covered in rejuvenated lavas, while the other half consists of shield stage lavas. The shield lavas around Fagaloa Bay are compositionally similar to some of the Tutuila lavas. On the island of Savaii, rejuvenated volcanism covers nearly the entire island, showing similar compositions to Upolu rejuvenated volcanism. We here present new data for samples from a deep canyon in the interior of Savaii, which form the missing link in understanding the geochemical sequence of Samoan volcanic construction. In this canyon, an isotopically distinct composition is found that resembles the composition of Fagaloa lavas on Upolu, instead of the extremely radiogenic Sr isotope compositions dredged from the submarine base of Savaii that represent the early shield stage. In Fagaloa Bay, a slope break on the mountainside has been suggested to form the outline of a crater along which late-stage evolved lavas such as

  9. Modeling Aging and Mechanical Rejuvenation of Amorphous Solids

    NASA Astrophysics Data System (ADS)

    Semkiv, Mykhailo; Hütter, Markus

    2016-04-01

    The elasto-viscoplasticity of amorphous solids is modeled, with a focus on the effects of physical aging and mechanical rejuvenation. Using nonequilibrium thermodynamics, the concept of kinetic and configurational subsystems has been employed. The Hamiltonian structure of reversible dynamics is exploited to derive a constitutive relation for the stress tensor. Furthermore, it is demonstrated that accounting for mechanical rejuvenation results in a modification of the driving force for viscoplastic flow.

  10. Shield Through Rejuvenated Stage Volcanism On Kauai and Niihau, Hawaii

    NASA Astrophysics Data System (ADS)

    Cousens, B.; Clague, D. A.

    2013-12-01

    Kauai and Niihau are the northwesternmost large islands in the Hawaiian chain and consist of shield, rare postshield, and abundant rejuvenated stage lavas. We present new geochronological, geochemical and isotopic data for all phases of volcanic activity on the adjacent islands. K-Ar ages show Niihau shield volcanism occurred from 6.3-4.4 Ma, and K-Ar and new Ar-Ar ages for postshield volcanism range from 5.4-4.7 Ma. Kauai shield volcanism (K-Ar) overlaps with shield volcanism on Niihau. A new Ar-Ar age for a Kauai postshield dike is 4.4 Ma, older than previously-dated postshield lavas (3.95-3.58 Ma). New Ar-Ar ages show that Kauai rejuvenated stage volcanism began prior to 3.42 Ma (Izuka & Sherrod, 2011), compared to ~2.3 Ma on Niihau. Tholeiitic shield lavas from Kauai vary only slightly in trace element chemistry but have variable isotopic compositions. Subtle trends in some trace element and isotopic ratios between Napali Member shield lavas from the east and west side of Kauai support the two-shield hypothesis of Holcomb et al. (1997). Shield lavas from Niihau are chemically similar to those on Kauai, although Niihau tholeiites extend to higher 143Nd/144Nd ratios. Onland and submarine postshield rocks from Niihau are slightly more alkaline and LREE-enriched compared to shield lavas, but postshield rocks from Kauai are more chemically evolved, more LREE-enriched, and have more depleted Sr and Nd isotopic signatures than Kauai tholeiites. Postshield rocks on Kauai overlap in apparent age with lavas that are chemically like later rejuvenated stage lavas, suggesting either interfingering of the chemically distinct lavas or problems with the K-Ar ages. Rejuvenated stage lavas from the two islands differ dramatically; Kauai lavas are alkaline, LREE-enriched, and have even more depleted Sr and Nd isotopic compositions than postshield lavas, whereas Niihau lavas are only mildly alkaline, have lower REE abundances than postshield basalts, but isotopically are like

  11. Happy Anniversary, VLT !

    NASA Astrophysics Data System (ADS)

    2004-04-01

    Five years at the service of Europe's astronomers VLT 5 Years One of the world's most advanced astronomical research facilities, the ESO Very Large Telescope (VLT) at the Paranal Observatory in the Chilean Atacama desert, celebrates an important anniversary today. On April 1, 1999, and following almost one year of extensive tests and careful trimming of its numerous high-tech parts, the first 8.2-m VLT Unit Telescope, Antu (UT1), was "handed over" to the astronomers. Since that date, science operations with this marvellous research tool have been continuous and intensive. Kueyen (UT2) started normal operations exactly one year later. Yepun (UT4) was offered to the scientific community in June 2001, while Melipal (UT3) followed in August 2001 [1]. Ever since, all four VLT Unit Telescopes, with an ever-growing suite of highly specialised, extremely powerful astronomical instruments have been in full operation, 365 nights a year. And this with unequalled success, as demonstrated by a long list of important scientific results, including a substantial number of exciting discoveries that are now opening new horizons in astrophysics. Moreover, thanks to heroic and persistent efforts by the dedicated teams of ESO scientists and engineers, the "downtime" due to technical problems has been very small, about 3 per cent, a number that is unequalled among the world's large telescope facilities. In addition, the weather conditions at the Paranal site in the dry Atacama desert in Northern Chile are truly excellent - this is indeed one of the best locations for astronomical observations on the surface of the Earth - and the corresponding "weather downtime" has only been around 10 per cent. This has resulted in an unbelievably low value of total downtime, most likely a new world record for ground-based 8-10 m class telescopes. VLT strong points The Very Large Telescope (VLT) is the world's largest and most advanced optical telescope. It comprises four 8.2-m reflecting Unit

  12. Robotic-Assisted Upper Face Rejuvenation

    PubMed Central

    Rybakin, Arthur V.; Manturova, Natalia E.; Gladyshev, Dmitriy V.; Kamalov, David M.; Shcherbakov, Kirill G.; Staisupov, Valeriy J.; Kuzin, Danila A.

    2016-01-01

    Summary: Robotic-assisted technology has not been used in aesthetic surgery so far. The authors examined the feasibility and potential advantages of robotic-assisted technology in upper face rejuvenation surgery, as well as utility of the tools available in the market. Forehead lift was performed along with blepharoplasty in 4 patients. Robotic da Vinci Surgical System (Intuitive Surgical, Inc.) was used at the stage of dissection. The stereo endoscope 30 degrees, 12 mm and later 8.5 mm in diameter, and the set of tools, 8 mm and later 5 mm in diameter, were used. Overall results appeared to be essentially the same as after usual endoscope-assisted brow lift. The advantages of the robotic-assisted surgery were as follows: the best possible display, scalability of the picture; lack of tremor, scalability of the movements’ amplitude; high degree of freedom of movements exceeding human capabilities; quick and easy switch between the endoscope and any of the 3 manipulating arms; and enhanced comfort for a surgeon. The drawbacks noted were as follows: cost, steep learning curve, lack of tactile feedback, and absence of instruments specially adjusted for aesthetic surgery. The authors conclude that robots will enter the field of aesthetic plastic surgery in the same way as endoscopy, the proviso being to adjust tools to the specific needs.

  13. Surface rejuvenating effect of Achillea millefolium extract.

    PubMed

    Pain, S; Altobelli, C; Boher, A; Cittadini, L; Favre-Mercuret, M; Gaillard, C; Sohm, B; Vogelgesang, B; André-Frei, V

    2011-12-01

    Proopiomelanocortin is a precursor peptide that gives rise to several neuropeptides including adrenocorticotrophic hormone (ACTH) and β-endorphin. POMC-derived peptides have been shown to be synthesized in human epidermis where they modulate numerous skin functions. Because we previously observed that melanocortin receptor-2 and μ-opioid receptor 1, the respective receptors for ACTH and β-endorphin decreased with ageing in human epidermis, we have selected an active ingredient (INCI name: Achillea millefolium extract) able to upregulate receptor expressions. The aim of the present work was first to evaluate the effect of A. millefolium extract on the expression pattern of various epidermal differentiation markers ex vivo in normal human skin biopsies using quantitative image analysis and second to evaluate its capacity to rejuvenate the appearance of skin surface in vivo. Results show an improved expression profile of cytokeratin 10, transglutaminase-1 and filaggrin in cultured skin biopsies as well as an increased epidermal thickness. In vivo, a 2-month treatment with A. millefolium extract at 2% significantly improved the appearance of wrinkles and pores compared with placebo. Results were also directionally better than those of glycolic acid that was chosen as reference resurfacing molecule. PMID:21711463

  14. 25th IAEA Fusion Energy Conference: summary of sessions EX/S, EX/W and ICC

    NASA Astrophysics Data System (ADS)

    Sen, A.

    2015-10-01

    This paper provides a summary overview, based on papers presented at the 25th IAEA Fusion Energy Conference (FEC), in the area of magnetic confinement experiments related to stability (EX/S), wave-plasma interactions, current drive, heating, energetic particles (EX/W) and innovative confinement concepts (ICCs). A selection of results that represent progress made since the last FEC in a few important thematic areas that are relevant for the successful and safe operation of future fusion devices like ITER, is highlighted.

  15. Newly diagnosed hyperthyroidism in the 25th gestational week of pregnancy presenting with systolic arterial hypertension only.

    PubMed

    Zaveljcina, Janez; Legan, Mateja; Gaberšček, Simona

    2016-05-01

    We present a case of a 30-year-old woman diagnosed with arterial hypertension in the 25th week of pregnancy. Our search for secondary causes of arterial hypertension revealed hyperthyroid Hashimoto's thyroiditis (HT), which was treated with propilthiouracil. Three weeks after delivery, she was normotensive without medication. In the next four months, she developed hypothyroidism and treatment with L-thyroxine was started. In conclusion, in the second half of pregnancy, a hyperthyroid HT can occur - in spite of the well-known amelioration of autoimmune thyroid disorders in that period, and can be the only cause of arterial hypertension. PMID:26979941

  16. Happy Anniversary, VLT !

    NASA Astrophysics Data System (ADS)

    2004-04-01

    Five years at the service of Europe's astronomers VLT 5 Years One of the world's most advanced astronomical research facilities, the ESO Very Large Telescope (VLT) at the Paranal Observatory in the Chilean Atacama desert, celebrates an important anniversary today. On April 1, 1999, and following almost one year of extensive tests and careful trimming of its numerous high-tech parts, the first 8.2-m VLT Unit Telescope, Antu (UT1), was "handed over" to the astronomers. Since that date, science operations with this marvellous research tool have been continuous and intensive. Kueyen (UT2) started normal operations exactly one year later. Yepun (UT4) was offered to the scientific community in June 2001, while Melipal (UT3) followed in August 2001 [1]. Ever since, all four VLT Unit Telescopes, with an ever-growing suite of highly specialised, extremely powerful astronomical instruments have been in full operation, 365 nights a year. And this with unequalled success, as demonstrated by a long list of important scientific results, including a substantial number of exciting discoveries that are now opening new horizons in astrophysics. Moreover, thanks to heroic and persistent efforts by the dedicated teams of ESO scientists and engineers, the "downtime" due to technical problems has been very small, about 3 per cent, a number that is unequalled among the world's large telescope facilities. In addition, the weather conditions at the Paranal site in the dry Atacama desert in Northern Chile are truly excellent - this is indeed one of the best locations for astronomical observations on the surface of the Earth - and the corresponding "weather downtime" has only been around 10 per cent. This has resulted in an unbelievably low value of total downtime, most likely a new world record for ground-based 8-10 m class telescopes. VLT strong points The Very Large Telescope (VLT) is the world's largest and most advanced optical telescope. It comprises four 8.2-m reflecting Unit

  17. Unspiked K-Ar Dating Of Hawaiian Rejuvenated Volcanism

    NASA Astrophysics Data System (ADS)

    Tagami, T.; Ozawa, A.; Sano, H.; Sherrod, D. R.

    2005-12-01

    Many mantle plume volcanoes undergo rejuvenated volcanism after a period of construction and erosion of their shield. The cause of this renewed volcanism has been enigmatic, and various models have been proposed. However, the lack of chronological data has hindered evaluating these models. Here we summarize below our recent results of unspiked K-Ar dating on rejuvenated lavas from five Hawaiian volcanoes. These ages, coupled with other geological and geophysical constraints, will be used to test the models. (1) Haleakala (East Maui) (Sherrod et al., 2003): The postshield and previously inferred rejuvenated-stage history was reevaluated using 52 new ages. Periods of low extrusion rates or volcanic quiescence occurred at ~0.76 - 0.65 Ma and ~0.45 - 0.29 Ma, both within the postshield Kula unit. The volcanic quiescence between postshield and supposed rejuvenated-stage units is about 0.03 m.y., much shorter than the previously estimated period of 0.25 - 0.30 m.y. (2) West Maui (Tagami et al., 2003; Sherrod et al., in prep.): Rejuvenated-stage Lahaina Volcanics were erupted from only four sites and their new ages indicate two volcanic pulses at about 0.6 and 0.4 Ma. Nine ages for the underlying postshield and 28 for shield stage units range from 1.8 - 1.3 Ma and 1.3 - 1.2 Ma, respectively. Therefore, the duration of volcanic quiescence prior to rejuvenation is about 0.6 m.y. at West Maui, much longer than estimated previously. (3) Koolau, Oahu (Ozawa et al., 2005): New ages on 41 samples from 32 vents of rejuvenated-stage Honolulu Volcanics and on eight samples of underlying shield-stage Koolau Volcanics show that shield volcanism ended at 2.1 Ma and that rejuvenated volcanism started at 0.8 Ma, resulting in a 1.3 m.y. hiatus in volcanic activity. Two distinct pulses were found for Honolulu volcanism at 0.8 - 0.35 and ~0.1 Ma. During the first pulse, the eruption frequency increased with time and there was no obvious spatial pattern in vent distribution. Volcanism

  18. Controlled Rejuvenation of Amorphous Metals with Thermal Processing

    PubMed Central

    Wakeda, Masato; Saida, Junji; Li, Ju; Ogata, Shigenobu

    2015-01-01

    Rejuvenation is the configurational excitation of amorphous materials and is one of the more promising approaches for improving the deformability of amorphous metals that usually exhibit macroscopic brittle fracture modes. Here, we propose a method to control the level of rejuvenation through systematic thermal processing and clarify the crucial feasibility conditions by means of molecular dynamics simulations of annealing and quenching. We also experimentally demonstrate rejuvenation level control in Zr55Al10Ni5Cu30 bulk metallic glass. Our local heat-treatment recipe (rising temperature above 1.1Tg, followed by a temperature quench rate exceeding the previous) opens avenue to modifying the glass properties after it has been cast and processed into near component shape, where a higher local cooling rate may be afforded by for example transient laser heating, adding spatial control and great flexibility to the processing. PMID:26010470

  19. Announcement: CDC's 70th Anniversary.

    PubMed

    2016-01-01

    July 1, 2016, marks the 70th anniversary of the establishment of CDC. Since the agency's launch as the Communicable Disease Center on July 1, 1946, CDC's primary mission has been improving public health in the United States and around the world through prevention and preparedness. In the seven decades since CDC's founding, the agency has grown in size and mission and is recognized as the nation's premiere health promotion, disease prevention, and emergency preparedness agency, and a global leader in public health. CDC's mission has progressed beyond communicable disease control and now encompasses noninfectious diseases, injury prevention, and environmental and occupational health. PMID:27362420

  20. Rejuvenation of the skin surface: chemical peel and dermabrasion.

    PubMed

    Branham, G H; Thomas, J R

    1996-04-01

    Chemical peel and dermabrasion are traditional, well-proven methods for the rejuvenation of the skin. The medium-depth trichloroacetic acid peel and the deep phenol peel offer distinct advantages and disadvantages and are discussed in detail in this article. The management of complications associated with both peel techniques is also discussed. Regional dermabrasion is an effective adjunct to facial rejuvenative surgery, such as face lift and blepharoplasty. Full-face dermabrasion and spot or local dermabrasion are most often used in the treatment of facial scarring. The technique of dermabrasion is discussed as well as its indications and postoperative care. Results are shown for both dermabrasion and peel. PMID:9220727

  1. Pins and needles: minimally invasive office techniques for facial rejuvenation.

    PubMed

    Maas, Corey S; Bapna, Sumit

    2009-11-01

    The desire for minimally invasive facial rejuvenation has continued to increase from the perspective of both the patients and injectors. For successful rejuvenation, it is important to understand the anatomic changes of the aging face as well as the properties of available neuromodulators and soft tissue fillers. The injector should be knowledgeable of the advantages and disadvantages of each product. Patient selection, perhaps, plays the largest role in success, choosing patients that would truly benefit from and have reasonable expectations for minimally invasive techniques. Unsatisfactory outcomes can be limited by meticulous injection technique and well thought out treatment plans. PMID:19924599

  2. Systemic Problems: A perspective on stem cell aging and rejuvenation.

    PubMed

    Conboy, Irina M; Conboy, Michael J; Rebo, Justin

    2015-10-01

    This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are "beyond parabiosis" for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging. PMID:26540176

  3. Systemic Problems: A perspective on stem cell aging and rejuvenation

    PubMed Central

    Conboy, Irina M.; Conboy, Michael J.; Rebo, Justin

    2015-01-01

    This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a “silver bullet” putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are “beyond parabiosis” for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging. PMID:26540176

  4. Update on hyaluronic acid fillers for facial rejuvenation.

    PubMed

    Mansouri, Yasaman; Goldenberg, Gary

    2015-08-01

    Injectable soft tissue filler procedures are becoming increasingly important for rejuvenating the aging face. The variety of available dermal fillers is increasing, and an understanding of their individual characteristics allows optimal outcomes. We provide an overview of the dermal fillers that were approved by the US Food and Drug Administration over the last 5 years. PMID:26367746

  5. Photopneumatic Technology in Acne Treatment and Skin Rejuvenation: Histological Assessment

    PubMed Central

    Omi, Tokuya

    2012-01-01

    Background and Aims: Recent reports indicate that a variety of light-based devices have been used for acne treatment and skin rejuvenation. A new technology combining intense pulsed light with negative pressure, photopneumatic technology, has recently attracted interest. The present study assessed acne treatment and skin rejuvenation with this novel approach Subjects and Methods: Acne, 450 nm tip. Five Japanese volunteers (1 male, 4 female; mean age 28.6 yr; skin type III) with mild to moderate/moderate active acne participated. The face was treated with 2 sessions, 2 weeks apart. Biopsies were obtained immediately after the first session and 1 week after the second session, and routinely processed for transmission electron microscopy (TEM). Rejuvenation, profusion tip with topical preparation. In 5 Japanese volunteers (3 male, 2 female; mean age 37.6 yr, skin type III), the volar aspect of both forearms was treated with the 530 nm head at P6 (around 12 J/cm2). The left arm was then treated with a pre-infused profusion tip and vacuum only. Four sessions were given, 14-day intervals. Biopsies were taken from both arms 2 weeks after the 2nd session and 3 weeks after the 4th session. One-half of each biopsy was assessed with histo-and immunohistochemistry, and the other with TEM. Results Acne trial: A combination of physical extraction of comedones, mild photothermal damage of the follicle and damage to identified bacilli was noted post-treatment, with macroscopic improvement of the skin. Rejuvenation with profusion: Significant morphological and immunohistochemical differences were seen between the control and profusion-treated arms at the first assessment. These differences became less significant at the 2nd assessment. Conclusions Macroscopically and histologically, photopneumatic technology improved acne lesions, suggesting a synergistic effect between the components of the technology. In skin rejuvenation, the profusion therapy accelerated the regenerative

  6. Brow suspension, a minimally invasive technique in facial rejuvenation.

    PubMed

    Erol, O Onur; Sozer, S Ozan; Velidedeoglu, Hifzi V

    2002-06-01

    People tend to prefer noninvasive or minimally invasive methods of facial rejuvenation, especially when it involves their face, which is the hallmark of a person's identity and impossible to hide. It is widely known that brow ptosis gives the face a "tired look" and also accentuates deformities of the upper eyelid. Most people who are interested in facial rejuvenation may not accept even a minor surgery, such as an endoscopic surgery. The senior author has developed a minimally invasive method of suspending the brow at a higher position. In this technique, there is neither surgical dissection nor a surgical incision except for four stab incisions and suture insertion, which is why we refer to it as a nonsurgical brow suspension. It is done under local anesthesia, and the brows are fixed in the position that they assume when the patient is supine. In the past 6 years, we performed 387 brow suspensions on 324 female and 63 male patients. The youngest patient was 19 years old, and the oldest was 74 years old. A retrospective chart review was done. These 387 cases were reviewed by comparison of preoperative and postoperative photographs. This approach was not only used for patients who were not interested in surgical rejuvenation but was also combined with lipofilling, laser resurfacing, and/or upper blepharoplasty. This technique is useful for correcting postsurgical brow asymmetry. We present this technique as an adjunct to the established techniques of facial rejuvenation. Despite the high patient acceptance and technical ease, it is not a replacement for the established techniques of facial rejuvenation. PMID:12045586

  7. Pandemic Influenza's 500th Anniversary

    PubMed Central

    Morens, David M.; Taubenberger, Jeffery K.; Folkers, Gregory K.; Fauci, Anthony S.

    2010-01-01

    It is impossible to know with certainty the first time that an influenza virus infected humans or when the first influenza pandemic occurred. However, many historians agree that the year 1510 a.d.—500 years ago—marks the first recognition of pandemic influenza. On this significant anniversary it is timely to ask: what were the circumstances surrounding the emergence of the 1510 pandemic, and what have we learned about this important disease over the subsequent five centuries?We conclude that in recent decades significant progress has been made in diagnosis, prevention, control, and treatment of influenza. It seems likely that, in the foreseeable future, we may be able to greatly reduce the burden of influenza pandemics with improved vaccines and other scientific and public health approaches. PMID:21067353

  8. The ESA Hubble 15th Anniversary Campaign

    NASA Astrophysics Data System (ADS)

    Christensen, L. L.; Kornmesser, M.

    2005-12-01

    The 15th anniversary of the launch of the NASA/ESA Hubble Space Telescope occurred on 24th April 2005. As Hubble is one of the most successful scientific projects in the world, ESA decided to celebrate this anniversary, among other things, with the production of a Hubble 15th Anniversary movie and a book, both called "Hubble, 15 years of discovery". The movie covers all aspects of the Hubble Space Telescope project - a journey through the history, the problems and the scientific successes of Hubble. With more than 700,000 multi-lingual DVDs distributed to the public, media, educators, decision-makers and scientists, the Hubble 15th anniversary campaign has been one of the largest such projects in Europe.

  9. Skin rejuvenation with non-invasive pulsed electric fields.

    PubMed

    Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P; Albadawi, Hassan; Felix Broelsch, G; Watkins, Michael T; Georgakoudi, Irene; Papisov, Mikhail; Mihm, Martin C; Austen, William G; Yarmush, Martin L

    2015-01-01

    Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases. PMID:25965851

  10. Skin Rejuvenation with Non-Invasive Pulsed Electric Fields

    PubMed Central

    Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P.; Albadawi, Hassan; Felix Broelsch, G.; Watkins, Michael T.; Georgakoudi, Irene; Papisov, Mikhail; Mihm Jr., Martin C.; Austen Jr., William G.; Yarmush, Martin L.

    2015-01-01

    Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases. PMID:25965851

  11. Skin Rejuvenation with Non-Invasive Pulsed Electric Fields

    NASA Astrophysics Data System (ADS)

    Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P.; Albadawi, Hassan; Felix Broelsch, G.; Watkins, Michael T.; Georgakoudi, Irene; Papisov, Mikhail; Mihm, Martin C., Jr.; Austen, William G., Jr.; Yarmush, Martin L.

    2015-05-01

    Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases.

  12. Visual Literacy in the Digital Age: Selected Readings from the Annual Conference of the International Visual Literacy Association (25th, Rochester, New York, October 13-17, 1993).

    ERIC Educational Resources Information Center

    Beauchamp, Darrel G.; And Others

    This document contains selected papers from the 25th annual conference of the International Visual Literacy Association (IVLA). Topics addressed in the papers include the following: visual literacy; graphic information in research and education; evaluation criteria for instructional media; understanding symbols in business presentations;…

  13. Deeply Rooted, Branching Out, 1972-1997. Annual AEE International Conference Proceedings (25th, Asheville, North Carolina, November 23-26, 1997).

    ERIC Educational Resources Information Center

    Harwell, Rick, Ed.; Comstedt, Timothea, Ed.; Roberts, Nina, Ed.

    This proceedings contains 36 papers presented at the 25th Annual Conference of the Association for Experiential Education. Papers are: "The Woods and the Trees: Interpreting Experiential Education for Schools and a Greater Audience" (Joanna Allen, John Hutchinson); "Adventure Programming & Prevention of Adolescent Problem Behaviors: Applying…

  14. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (25th, Utrecht, The Netherlands, July 12-17, 2001). Volumes 1-4.

    ERIC Educational Resources Information Center

    van den Heuvel-Panhuizen, Marja, Ed.

    This document contains the proceedings of the 25th annual Conference of the International Group for the Psychology of Mathematics Education (PME). It features plenary lectures, research forums, discussion groups, working sessions, short oral communications, and poster presentations. Papers in Volume 1 include: (1) "The P in PME: Progress and…

  15. Teaching of Psychology: Ideas and Innovations. Proceedings of the Annual Conference (25th, Tarrytown, New York, March 25-26, 2011)

    ERIC Educational Resources Information Center

    Howell-Carter, Marya, Ed.; Gonder, Jennifer, Ed.

    2011-01-01

    Conference proceedings of the 25th Annual Conference on the Teaching of Psychology: Ideas and Innovations, sponsored by the Psychology Department of the State University of New York at Farmingdale. The conference theme for 2011 was: The Future of the Undergraduate Psychology Major: New Directions in an Evolving Educational Climate. The Conference…

  16. Months between rejuvenation and volcanic eruption at Yellowstone caldera, Wyoming

    USGS Publications Warehouse

    Till, Christy B.; Vazquez, Jorge A.; Boyce, Jeremy W

    2015-01-01

    Rejuvenation of previously intruded silicic magma is an important process leading to effusive rhyolite, which is the most common product of volcanism at calderas with protracted histories of eruption and unrest such as Yellowstone, Long Valley, and Valles, USA. Although orders of magnitude smaller in volume than rare caldera-forming super-eruptions, these relatively frequent effusions of rhyolite are comparable to the largest eruptions of the 20th century and pose a considerable volcanic hazard. However, the physical pathway from rejuvenation to eruption of silicic magma is unclear particularly because the time between reheating of a subvolcanic intrusion and eruption is poorly quantified. This study uses geospeedometry of trace element profiles with nanometer resolution in sanidine crystals to reveal that Yellowstone’s most recent volcanic cycle began when remobilization of a near- or sub-solidus silicic magma occurred less than 10 months prior to eruption, following a 220,000 year period of volcanic repose. Our results reveal a geologically rapid timescale for rejuvenation and effusion of ~3 km3 of high-silica rhyolite lava even after protracted cooling of the subvolcanic system, which is consistent with recent physical modeling that predict a timescale of several years or less. Future renewal of rhyolitic volcanism at Yellowstone is likely to require an energetic intrusion of mafic or silicic magma into the shallow subvolcanic reservoir and could rapidly generate an eruptible rhyolite on timescales similar to those documented here.

  17. Case study: An isolated severe storm with giant hail hit Slovenian capital city Ljubljana on May 25th 2009

    NASA Astrophysics Data System (ADS)

    Korosec, M.

    2009-09-01

    Introduction A quite unusual weather pattern for month of May with first and early season heat wave of year 2009 resulted in several days of active severe storms across central Europe and Alpine region. Synoptic situation On May 25th 2009, an omega block pattern with strong upper-level subtropical ridge extending over Mediterranean and Balkan Peninsula brought stable and warm conditions into Southern Europe. Elsewhere, two large-scale troughs were located over Western and Eastern Europe with very unstable environment. On the nose of the Mediterranean ridge a jet streak with moderate shear was placed while over the Southern Alpine region only weak shear was placed over Slovenia. Rich boundary layer moisture and steep lapse rates within an elevated mixed layer favored extreme amounts of CAPE. After strong diurnal heating and surface wind convergence along the local topography a few convective cells were triggered in the mountainous terrain while deep moist convection over the rest of Slovenia was trapped by the strong capping inversion. In late afternoon several cells from the mountainous terrain interfered with each other and explosive convective cell was initiated along their outflow boundaries. Increasing near surface southeasterly wind flow supported enhanced low-level shear and storm relative helicity which caused this cell to very rapidly grown into an organized supercell storm on the flat terrain in northern Slovenia. This supercell then started racing southeastwards towards Ljubljana, a capital city of Slovenia. It caused extensive hail damage with very large to giant hailstones up to 7cm in diameter falling over parts of Ljubljana and areas north and southeast of the city. Presentation of research This case study will go through a research of this very damaging hailstorm, throughout a detailed analysis of the synoptic situation including analysis of satellite, radar and surface observations. At first, forecasting models did not suggest organized convection

  18. MedlinePlus Marks its 15th Anniversary

    MedlinePlus

    ... page: https://medlineplus.gov/anniversary.html MedlinePlus Marks its 15 th Anniversary To use the sharing features ... people across the country and around the world. It now includes: Over 950 pages providing links to ...

  19. The silver anniversary of gold: 25 years of the colloidal gold marker system for immunocytochemistry and histochemistry.

    PubMed

    Roth, J

    1996-07-01

    Since 1971, when W.P. Faulk and G.M. Taylor published "An immunocolloid method for the electron microscope", colloidal gold has become a very widely used marker in microscopy. It has been used to detect a huge range of cellular and extracellular constituents by in situ hybridization, immunogold, lectin-gold, and enzyme-gold labeling. Besides its use in light microscopic immunogold and lectin-gold silver staining, colloidal gold remains the label of choice for transmission electron microscopy studying thin sections, freeze-etch, and surface replicas, as well as for scanning electron microscopy. The year 1996 is the 25th anniversary of the introduction of colloidal gold as a marker in immunoelectron microscopy and this overview outlines some of the major milestones in the development of the colloidal gold marker system. PMID:8858362

  20. 46 CFR 90.10-1 - Anniversary date.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Definition of Terms Used in This Subchapter § 90.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate of... 46 Shipping 4 2013-10-01 2013-10-01 false Anniversary date. 90.10-1 Section 90.10-1 Shipping...

  1. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate... 46 Shipping 7 2011-10-01 2011-10-01 false Anniversary date. 188.10-1 Section 188.10-1...

  2. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate... 46 Shipping 7 2012-10-01 2012-10-01 false Anniversary date. 188.10-1 Section 188.10-1...

  3. 46 CFR 90.10-1 - Anniversary date.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Definition of Terms Used in This Subchapter § 90.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate of... 46 Shipping 4 2011-10-01 2011-10-01 false Anniversary date. 90.10-1 Section 90.10-1 Shipping...

  4. 46 CFR 90.10-1 - Anniversary date.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Definition of Terms Used in This Subchapter § 90.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate of... 46 Shipping 4 2014-10-01 2014-10-01 false Anniversary date. 90.10-1 Section 90.10-1 Shipping...

  5. 46 CFR 90.10-1 - Anniversary date.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Definition of Terms Used in This Subchapter § 90.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate of... 46 Shipping 4 2012-10-01 2012-10-01 false Anniversary date. 90.10-1 Section 90.10-1 Shipping...

  6. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate... 46 Shipping 7 2010-10-01 2010-10-01 false Anniversary date. 188.10-1 Section 188.10-1...

  7. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate... 46 Shipping 7 2014-10-01 2014-10-01 false Anniversary date. 188.10-1 Section 188.10-1...

  8. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate... 46 Shipping 7 2013-10-01 2013-10-01 false Anniversary date. 188.10-1 Section 188.10-1...

  9. 46 CFR 90.10-1 - Anniversary date.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Definition of Terms Used in This Subchapter § 90.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate of... 46 Shipping 4 2010-10-01 2010-10-01 false Anniversary date. 90.10-1 Section 90.10-1 Shipping...

  10. Strong rejuvenation in a chiral-glass superconductor

    NASA Astrophysics Data System (ADS)

    Gardchareon, A.; Mathieu, R.; Jönsson, P. E.; Nordblad, P.

    2003-02-01

    The glassy paramagnetic Meissner phase of a Bi2Sr2CaCu2Ox superconductor (x=8.18) is investigated by superconducting quantum interference device magnetometry, using “dc-memory” experiments employed earlier to study spin glasses. The temperature dependence of the zero-field-cooled and thermoremanent magnetization is recorded on reheating after specific cooling protocols, in which single or multiple halts are performed at constant temperatures. The “spin” states equilibrated during the halts are retrieved on reheating. The observed memory and rejuvenation effects are similar to those observed in Heisenberg-like spin glasses.

  11. Hand Rejuvenation: A Comprehensive Review of Fat Grafting.

    PubMed

    Hoang, Don; Orgel, Matthew I; Kulber, David A

    2016-05-01

    Dermal atrophy, bulging reticular veins, and prominent bones and tendons are characteristic of the aging hand. Demand for cosmetic procedures to restore a youthful appearance to the dorsum of the hand has risen in recent years. A review of the literature reveals that of the many options for hand restoration, autologous fat grafting stands out as the most promising choice compared with many available alternative options such as microdermabrasion, peeling agents, and dermal fillers. This article details the surgical technique and relevant anatomy necessary for successful hand rejuvenation. Future advancements may rely on further study into adipose-derived stem cells. PMID:27113709

  12. Injectable Filler Techniques for Facial Rejuvenation, Volumization, and Augmentation.

    PubMed

    Bass, Lawrence S

    2015-11-01

    Multiple fillers are available: various hyaluronic acid products, calcium hydroxylapatite, and a few others that are biocompatible with good duration and a variety of mechanical properties allowing intradermal, subdermal, and supraperiosteal injection. Facial features can be reshaped with great control using these fillers. Aging changes, including facial volume loss, can be well-corrected. These treatments have become a mainstay of rejuvenation in the early facial aging patient. Injection technique is critical to obtaining excellent results. Threading, fanning, cross-hatching, bleb, and pillar techniques must be mastered. Technical execution can only measure up to, but not exceed, the quality of the aesthetic analysis. PMID:26505544

  13. Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

    PubMed Central

    Rando, Thomas A.; Chang, Howard Y.

    2012-01-01

    The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges. PMID:22265401

  14. Addressing anniversary reactions of trauma through group process: the Hurricane Katrina anniversary wellness workshops.

    PubMed

    Nemeth, Darlyne G; Kuriansky, Judy; Reeder, Kenneth P; Lewis, Amity; Marceaux, Kristin; Whittington, Taighlor; Olivier, Traci W; May, Natasha E; Safier, Jessica A

    2012-01-01

    Natural disasters such as Hurricane Katrina, which devastated the Gulf Coast of the United States in the summer of 2005, have highlighted the need to develop effective post-trauma psychotherapeutic intervention strategies, not only to deal with the immediate psychological aftermath of trauma, but also the long-term effects of anniversary reactions. Governmental responses to Hurricane Katrina relief were greatly criticized for disorganization and delay. Both immediately afterwards and in ensuing months, people's life needs often were not addressed. People-to-people individual and group grassroots efforts, including those provided by mental health professionals, however, did reach local communities to service immediate needs and long-term emotional reactions. The present paper describes one such effort designed to help survivors cope on the occasion of the first anniversary of Hurricane Katrina. Specifically, anniversary reaction group workshops were held to address unresolved emotional issues and to promote healing by encouraging belonging, comfort, security, and resilience. The ultimate goal of these wellness workshops was to assist participants in understanding and resolving their anniversary reactions. Preliminary quantitative and qualitative findings suggested that this workshop format helped participants face their anniversary reactions, address their related psychological sequelae, and deal with their physical displacement. Participants were then able to find the emotional strength to reattach, form new communities, and begin problem solving. These methods, with appropriate cultural modifications, were subsequently used in China, to assist Chinese mental health professionals prepare for the first anniversary of the Sichuan earthquake. PMID:22229372

  15. Rejuvenation in scale-free optics and enhanced diffraction cancellation life-time.

    PubMed

    Parravicini, J; Conti, C; Agranat, A J; DelRe, E

    2012-11-19

    We demonstrate rejuvenation in scale-free optical propagation. The phenomenon is caused by the non-ergodic relaxation of the dipolar glass that mediates the photorefractive nonlinearity in compositionally-disordered lithium-enriched potassium-tantalate-niobate (KTN:Li). We implement rejuvenation to halt aging in the dipolar glass and extend the duration of beam diffraction cancellation. PMID:23187594

  16. EDITORIAL: 50th anniversary issue

    NASA Astrophysics Data System (ADS)

    Beddoe, Alun H.

    2006-07-01

    In July 1956, 50 years ago, the first issue of Physics in Medicine and Biology (PMB) was published. It was subtitled The Journal of the Hospital Physicists' Association and published in association with the Philosophical Magazine by Taylor and Francis. Subscriptions were £1 per part or £3 10s for an annual subscription. The Editor, Professor J E Roberts, prefaced the first issue with a cautious editorial noting: The appearance of a new journal is usually greeted with mixed feelings by scientific workers, a common response being that there are far too many journals already. Justification for a new publication is only possible if there is a clearly defined gap in the publishing facilities available to workers in a particular scientific field.... Professor Roberts ended by seeking support from the scientific community for the new venture. He certainly got it! From a tentative few hundred pages in four issues a year for the first few years, the journal is now issued twice monthly with nearly 8000 pages expected in volume 51. In this anniversary issue we have invited some 28 senior authors to submit papers on a range of subjects spanning the discipline. We decided that to be an author one had to be old, but age was not to be the only criterion! Indeed readers will recognize all names as major contributors to both the development of medical physics and the success of PMB. Authors were not asked to write formal topical reviews of the state-of-the-art of the sub-disciplines which make up medical physics, but rather to present short historical reviews, didactic in style, perhaps highlighting the role of PMB in the development of their fields. Nevertheless, other than a page limit (which many subsequently ignored!) no formal format was imposed on authors, so what follows is a range of contributions from the almost conversational, personal statement to the more formal and familiar scientific paper. Whatever the writing style we are confident that readers will gain some

  17. The Neglected Majority--20th Anniversary

    ERIC Educational Resources Information Center

    Beebe, Anthony E.; Walleri, R. Dan

    2005-01-01

    It is the 20th anniversary of the release of Dale Parnell's landmark book "The Neglected Majority". In this book, Parnell pointed out that for too long America's educational system has focused on the highest and lowest achievers. He made the case that most of those students in the middle two high school quartiles neither prepare for nor aspire to…

  18. [World War II 50th Anniversary.

    ERIC Educational Resources Information Center

    Johnson, Jeniffer, Ed.

    1991-01-01

    This edition of "Loblolly," a periodical published by Texas high school students, commemorates the 50th anniversary of World War II. The volume features remembrances of the War by veterans of Panola County, Texas. In addition to transcriptions of conversations with veterans, reproductions of photographs--some from the war period, some from more…

  19. Hydration of Acetylene: A 125th Anniversary

    ERIC Educational Resources Information Center

    Ponomarev, Dmitry A.; Shevchenko, Sergey M.

    2007-01-01

    The year 2006 is the 125th anniversary of a chemical reaction, the discovery of which by Mikhail Kucherov had a profound effect on the development of industrial chemistry in the 19-20th centuries. This was the hydration of alkynes catalyzed by mercury ions that made possible industrial production of acetaldehyde from acetylene. Historical…

  20. Space agency notes 20th anniversary

    NASA Technical Reports Server (NTRS)

    Frosch, R. A.

    1978-01-01

    The twentieth anniversary of NASA is announced. A chronology of major milestones of the NASA program is given along with a brief outline of the programs and responsibilities of NASA Headquarters and the NASA centers and facilities. The NASA launch record is included.

  1. Columbines 10th Anniversary Finds Lessons Learned

    ERIC Educational Resources Information Center

    Trump, Kenneth S.

    2009-01-01

    When school administrators hear that the 10th anniversary of the Columbine High School attack is approaching, most shake their heads in disbelief. They are amazed that 10 years have passed since this watershed event, which changed the landscape of K-12 school safety. In this article, the author reflects on the lessons learned from the Columbine…

  2. The First Reactor, 40th Anniversary (rev.)

    SciTech Connect

    Allardice, Corbin; Trapnell, Edward R; Fermi, Enrico; Fermi, Laura; Williams, Robert C

    1982-12-01

    This booklet, an updated version of the original booklet describing the first nuclear reactor, was written in honor of the 40th anniversary of the first reactor or "pile". It is based on firsthand accounts told to Corbin Allardice and Edward R. Trapnell, and includes recollections of Enrico and Laura Fermi.

  3. A possible mechanism for visible-light-induced skin rejuvenation

    NASA Astrophysics Data System (ADS)

    Longo, Leonardo; Lubart, Rachel; Friedman, Harry; Lavie, R.

    2004-09-01

    In recent years there has been intensive research in the field of non-ablative skin rejuvenation. This comes as a response to the desire for a simple method of treating rhytids caused by aging, UV exposure and acne scars. In numerous studies intense visible light pulsed systems (20-30J/cm2) are used. The mechanism of action was supposed to be a selective heat induced denaturalization of dermal collagen that leads to subsequent reactive synthesis. In this study we suggest a different mechanism for photorejuvenation based on light induced Reactive Oxygen Species (ROS) formation. We irradiated collagen in-vitro with a broad band of visible light, 400-800 nm, 12-22J/cm2, and used the spin trapping coupled with electron paramagnetic resonance (EPR) spectroscopy to detect ROS. In vivo, we used dose 30 J in average (35 for acnis scars, 25 for wrinkles and redness). Irradiated collagen results in hydroxyl and methyl radicals formation. We propose, as a new concept, that visible light at the intensity used for skin rejuvenation, 20-30J/cm2, produces high amounts of ROS which destroy old collagen fibers encouraging the formation of new ones. On the other hand at inner depths of the skin, where the light intensity is much weaker, low amounts of ROS are formed which are well known to stimulate fibroblast proliferation.

  4. Extracellular Matrix Modulation: Optimizing Skin Care and Rejuvenation Procedures.

    PubMed

    Widgerow, Alan D; Fabi, Sabrina G; Palestine, Roberta F; Rivkin, Alexander; Ortiz, Arisa; Bucay, Vivian W; Chiu, Annie; Naga, Lina; Emer, Jason; Chasan, Paul E

    2016-04-01

    Normal aging and photoaging of the skin are chronic processes that progress gradually. The extracellular matrix (ECM), constituting over 70% of the skin, is the central hub for repair and regeneration of the skin. As such, the ECM is the area where changes related to photodamage are most evident. Degradation of the ECM with fragmentation of proteins significantly affects cross talk and signaling between cells, the matrix, and its constituents. The accumulation of collagen fragments, amorphous elastin agglutinations, and abnormal cross-linkages between the collagen fragments impedes the ECM from its normal repair and regenerative capacity, which manifests as wrinkled, non-elastic skin. Similar to how the chronic wound healing process requires wound bed preparation before therapeutic intervention, treatment of chronic aging of the skin would likely benefit from a "skin bed preparation" to optimize the outcome of rejuvenation procedures and skin maintenance programs. This involves introducing agents that can combat stress-induced oxidation, proteasome dysfunction, and non-enzymatic cross linkages involved in glycation end products, to collectively modulate this damaged ECM, and upregulate neocollagenesis and elastin production. Agents of particular interest are matrikines, peptides originating from the fragmentation of matrix proteins that exhibit a wide range of biological activities. Peptides of this type (tripeptide and hexapeptide) are incorporated in ALASTIN™ Skin Nectar with TriHex™ technology (ALASTIN Skincare, Inc., Carlsbad, CA), which is designed to target ECM modulation with a goal of optimizing results following invasive and non-invasive dermal rejuvenating procedures. PMID:27050707

  5. Lymphedema fat graft: an ideal filler for facial rejuvenation.

    PubMed

    Nicoli, Fabio; Chilgar, Ram M; Sapountzis, Stamatis; Lazzeri, Davide; Sze Wei, Matthew Yeo; Ciudad, Pedro; Nicoli, Marzia; Lim, Seong Yoon; Chen, Pei-Yu; Constantinides, Joannis; Chen, Hung-Chi

    2014-09-01

    Lymphedema is a chronic disorder characterized by lymph stasis in the subcutaneous tissue. Lymphatic fluid contains several components including hyaluronic acid and has many important properties. Over the past few years, significant research has been performed to identify an ideal tissue to implant as a filler. Because of its unique composition, fat harvested from the lymphedema tissue is an interesting topic for investigation and has significant potential for application as a filler, particularly in facial rejuvenation. Over a 36-month period, we treated and assessed 8 patients with lymphedematous limbs who concurrently underwent facial rejuvenation with lymphedema fat (LF). We conducted a pre- and post-operative satisfaction questionnaire survey and a histological assessment of the harvested LF fat. The overall mean general appearance score at an average of 6 months after the procedure was 7.2±0.5, demonstrating great improvement. Patients reported significant improvement in their skin texture with a reading of 8.5±0.7 and an improvement in their self-esteem. This study demonstrates that LF as an ideal autologous injectable filler is clinically applicable and easily available in patients with lymphedema. We recommend the further study and clinical use of this tissue as it exhibits important properties and qualities for future applications and research. PMID:25276654

  6. Multidisciplinary Investigations of the Galápagos Rift, 86°W to 89.5°W: 25th Anniversary of the Discovery of Hydrothermal Venting

    NASA Astrophysics Data System (ADS)

    Hammond, S. R.; Shank, T. M.; Fornari, D. J.; Yoerger, D. R.; Bradley, A. M.; Scheirer, D. S.; Tivey, M. A.

    2002-12-01

    In May-June, 2002, a multidisciplinary expedition comprised of biologists, chemists, geologists and engineers conducted a field program on the Galápagos Rift between 86°W and 89.5°W. Objectives of the expedition included revisiting the site of one of the first-discovered low-temperature hydrothermal vents at Rose Garden (originally found in 1979), and searching for new low- and high-temperature vents along the largely unexplored western portion of the Galápagos Rift to 89.5°W. The field work was funded primarily by NOAA's Ocean Exploration Program with additional support from the National Science Foundation and Woods Hole Oceanographic Institution. A synergistic array of deep-ocean vehicles was used for the exploration program. Alvin and a new digital towed camera were used for making seafloor observations, acquiring digital imagery and collecting samples. An autonomous vehicle ABE (Autonomous Benthic Explorer), which acquired meter-scale bathymetry, near-bottom magnetics and bottom water-properties data, was utilized to explore for active hydrothermal venting. Water-column vertical casts and tow-yos with a CTD/rosette were used to explore for plumes emanating from high-temperature vents. Alvin and ABE were used to explore for the Rose Garden vent field near 86°13.5'W. Detailed bottom-water temperature maps and seafloor magnetics data, in conjunction with visual and photographic observations from Alvin and the towed camera, confirmed that the Rose Garden vent field and associated animal community no longer exists, and that prolonged high-temperature venting appears to never have occurred in this area. However, a new low-temperature vent field (which was named Rosebud) was discovered nearby at a depth of 2450 m, and was found to be developing on a fresh-looking sheet flow at a location approximately 200 m northwest of the former Rose Garden area. A second site of low-temperature hydrothermal activity, at 1670 m, was discovered on a portion of the unexplored rift near 89.5°W. This venting is the first discovered along this portion of the Galápagos Rift and it hosts a large vesicomyid (C. magnifica) clam community that covers an approximately 60 m x 60 m area. Throughout the cruise, ABE was used during night operations to provide synoptic micro-bathymetry maps, magnetics data and bottom water properties. Early each morning, these data were processed and then provided to the Alvin observers prior to that same day's dive. ABE data were occasionally combined with, or supplanted by, data from the towed camera or the CTD. A total of 9 Alvin dives, 7 ABE dives, 5 camera tows and 6 CTD tows/casts were conducted. Detailed micro-bathymetric maps and mosaics of the vent communities will be presented.

  7. Academic Libraries and the Sciences: Assuring Successful Scholarship. Proceedings of a Program in Celebration of the 25th Anniversary of the University of California, Irvine and in Anticipation of Its New Science Library (Irvine, California, April 9, 1991).

    ERIC Educational Resources Information Center

    California Univ., Irvine.

    This document on successful scholarship in the sciences contains a keynote paper followed by six faculty responses. The keynote paper, delivered by Phillip Abelson of the American Association for the Advancement of Science (AAAS), is entitled "Assuring Successful Scholarship in the Sciences." Some of the factors likely to influence the nature of…

  8. Noninvasive Facial Rejuvenation. Part 3: Physician-Directed-Lasers, Chemical Peels, and Other Noninvasive Modalities.

    PubMed

    Meaike, Jesse D; Agrawal, Nikhil; Chang, Daniel; Lee, Edward I; Nigro, Marjory G

    2016-08-01

    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin and rejuvenate damaged skin. Physicians may recommend and often prescribe certain products, but patients are in control with this type of facial rejuvenation. On the other hand, physician-directed facial rejuvenation entails modalities that require direct physician involvement, such as neuromodulators, filler injections, laser resurfacing, microdermabrasion, and chemical peels. With the successful integration of each of these modalities, a complete facial regimen can be established and patient satisfaction can be maximized. This article is the last in a three-part series describing noninvasive facial rejuvenation. Here the authors review the mechanism, indications, and possible complications of lasers, chemical peels, and other commonly used noninvasive modalities. PMID:27478423

  9. Noninvasive Facial Rejuvenation. Part 2: Physician-Directed-Neuromodulators and Fillers.

    PubMed

    Dickey, Ryan M; Louis, Matthew R; Cox, Joshua A; Mohan, Kriti; Lee, Edward I; Nigro, Marjory G

    2016-08-01

    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin as well as rejuvenate damaged skin. Physicians may recommend and often prescribe certain products, but patients are in control with this type of facial rejuvenation. On the other hand, physician-directed facial rejuvenation entails modalities that require direct physician involvement, such as neuromodulators, filler injections, laser resurfacing, microdermabrasion, and chemical peels. With the successful integration of each of these modalities, a complete facial regimen can be established and patient satisfaction can be maximized. This article is the second in a three-part series describing noninvasive facial rejuvenation. Here the authors discuss neuromodulators and fillers in detail, focusing on indications for use, techniques, and common side effects. PMID:27478422

  10. Copious, Long-lived Rejuvenated Volcanism in the Northern Hawaiian Islands

    NASA Astrophysics Data System (ADS)

    Garcia, M. O.; Weis, D.; Hanano, D. W.; Jicha, B. R.; Ito, G.

    2015-12-01

    New marine surveying and submersible sampling of Kaul'a Volcano, located 100 km off the axis of the Hawaiian Chain, have revealed widespread areas of young volcanism. New 40Ar/39Ar and geochemical analyses of the olivine-phyric submarine and subaerial volcanic rocks show that Kaul'a is shrouded with young alkalic basalts (1.9 to 0.5 Ma). The ages and chemistry of these rocks overlap with rejuvenated lavas from nearby shields Ni'ihau, Kaua'i and South Kaua'i Swell. Collectively, rejuvenated lavas cover a vast area (~7000 km2) in the northern Hawaiian Islands. Kaul'a rejuvenated lavas show a much larger (5x) variation of incompatible elements than those from adjacent Ni'ihau but comparable to Honolulu rejuvenated lavas. Unlike both suites, heavy REE elements in Kaul'a lavas are pinned at Ybn 10, indicating a strong garnet signature in the source. Rejuvenated lavas from the Kaua'i Ridge have slightly higher radiogenic Pb isotope ratios than those from the southern Hawaiian Islands (Maui to O'ahu) and partly straddle the LOA-KEA boundary. Rejuvenated volcanism was nearly coeval occurrence from ~0.3 to 0.6 Ma along a 450 km segment of the Hawaiian Islands (West Maui to north of Ni'ihau), which is inconsistent with most models for rejuvenated volcanism except the Ballmer et al.2 dynamic melting model. This model invokes increasing pyroxenite contributions and the interaction with scale-scale convection rolls in the lithosphere to enhance the volume and duration of rejuvenation volcanism. Thus, a pyroxenite-bearing, mixed Kea-Loa source component may have contributed to the prolonged and extensive rejuvenated volcanism in the northern Hawaiian Islands. 1Robinson & Eakins 2006, J. Vol. Geotherm. Res., 151, 309-317; 2Ballmer et al. 2011, Nat. Geosc. 4, 457-460.

  11. Use of Aquamid as a filler for facial rejuvenation in orientals.

    PubMed

    Yagi, Yoichi; Kato, Kentaro; Murakami, Daisuke; Misaki, Kojiro; Ota, Mitsuya; Kataoka, Jiro; Yukawa, Naoki

    2009-10-01

    We used Aquamid as a filler for facial augmentation and rejuvenation in Orientals. This article introduces the injection techniques, effects, adequate dosage and complications of this filler, especially about rejuvenation of nasolabial fold and nasojugal groove. From December 2002 to June 2007, 5676 patients were treated in our clinic group. Complications were relatively minimal (0.082%) in comparison to other fillers and long-term effects were revealed. This is the first report concerning Aquamid use in facial rejuvenation of the Orientals. PMID:19303835

  12. Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells.

    PubMed

    Akunuru, Shailaja; Geiger, Hartmut

    2016-08-01

    Aging is associated with reduced organ function and increased disease incidence. Hematopoietic stem cell (HSC) aging driven by both cell intrinsic and extrinsic factors is linked to impaired HSC self-renewal and regeneration, aging-associated immune remodeling, and increased leukemia incidence. Compromised DNA damage responses and the increased production of reactive oxygen species (ROS) have been previously causatively attributed to HSC aging. However, recent paradigm-shifting concepts, such as global epigenetic and cytoskeletal polarity shifts, cellular senescence, as well as the clonal selection of HSCs upon aging, provide new insights into HSC aging mechanisms. Rejuvenating agents that can reprogram the epigenetic status of aged HSCs or senolytic drugs that selectively deplete senescent cells provide promising translational avenues for attenuating hematopoietic aging and, potentially, alleviating aging-associated immune remodeling and myeloid malignancies. PMID:27380967

  13. Facial rejuvenation starts in the midface: three-dimensional volumetric facial rejuvenation has beneficial effects on nontreated neighboring esthetic units.

    PubMed

    Wollina, Uwe

    2016-03-01

    Facial aging is a major indication for minimal invasive esthetic procedures. Dermal fillers are a cornerstone in the approach for facial sculpturing. But where to start? Our concept is midfacial volume restoration in first place. This will result in a healthy and youthful appearance creating a facial V-shape. But midfacial filler injection does not only improve the malar area. It has also beneficial effects on neighboring esthetic units. We report on such improvements in periocular and nasolabial region, upper lips and perioral tissue, and the jaw line and discuss anatomical background. We hypothesize that midfacial deep filler injections also may activate subdermal white adipose tissue stem cells contributing to longer lasting rejuvenation. PMID:26304759

  14. Study on Laser-Assisted Rejuvenation of Inter-Granular Corrosion Damaged Type 304 Stainless Steel

    NASA Astrophysics Data System (ADS)

    Gupta, R. K.; Bhardwaj, V. K.; Agrawal, D. K.; Kumar, Manoj; Upadhyay, B. N.; Sankar, P. Ram; Ganesh, P.; Kaul, R.; Oak, S. M.; Kukreja, L. M.

    2015-09-01

    The paper evaluates laser surface melting treatment for rejuvenation of inter-granular corrosion damaged type 304 stainless steel. Surface melting of inter-granular corrosion damaged specimens with CW CO2 and pulsed Nd:YAG lasers was quite effective in sealing surface damage. However, inter-granular corrosion susceptibility of laser-rejuvenated surface was strongly influenced by associated thermal exposure. With respect to CW CO2 laser, pulsed Nd:YAG laser-rejuvenated surface demonstrated significantly suppressed micro-structural damage and IGC-susceptibility. Compact pulsed Nd:YAG laser, with flexible beam transportation, presents an effective tool for in-situ rejuvenation of inter-granular corrosion damaged in-service stainless steel components operating in susceptible environments.

  15. Predicting gully rejuvenation after wildfire using remotely sensed burn severity data

    NASA Astrophysics Data System (ADS)

    Hyde, Kevin; Woods, Scott W.; Donahue, Jack

    2007-05-01

    The loss of surface vegetation and reduced infiltration caused by wildfires can trigger gully rejuvenation, resulting in damage to downstream aquatic resources and risk to human life and property. We developed a spatially explicit metric of burn severity — the Burn Severity Distribution Index (BSDI) — and tested its ability to predict post-fire gully rejuvenation in 1st and 2nd order basins burned in the 2000 Valley Complex fires in the Sapphire Mountains of western Montana. The BSDI was derived from burn severity data interpreted from Landsat 7 satellite imagery using the Normalized Burn Ratio (NBR) method, and ranged from 0.0 for completely unburned basins to 4.0 for basins burned entirely at high severity. In July 2001 rainstorms with peak 30-minute intensities of up to 17 mm h - 1 triggered gully rejuvenation in 66 of the 171 basins examined. The frequency of gully rejuvenation was higher in basins with higher BSDI values, increasing from zero for basins with a BSDI less than 1.3 to 67% for basins with a BSDI greater than 3.0. Binary logistic regression indicated that BSDI was a more significant predictor of gully rejuvenation than basin morphometric variables. The absence of gully rejuvenation in several basins with a high BSDI was attributed to low gradient, dense riparian vegetation, or concentration of high burn severity at lower elevations in the basin. The presence of gully rejuvenation in several basins with a low BSDI was associated with false negative NBR classification errors in northwest aspects, and concentration of severe burn impacts in the drainage headslopes. BSDI is a useful metric for predicting gully rejuvenation after wildfire. The use of the BSDI in Burned Area Emergency Response team assessments could improve the planning, implementation, and monitoring of burned area recovery treatments.

  16. 'Recharge my exhausted batteries': Overbeck's Rejuvenator, Patenting, and Public Medical Consumers, 1924-37.

    PubMed

    Stark, James F

    2014-10-01

    Although historians have shown that there has been a complex and multi-layered relationship between the body, medicine and the force of electricity, many avenues remain to be explored. One of the most prominent of these is the way in which electrotherapy technologies were marketed to a wide variety of different end users and intermediaries. This paper offers the first historical analysis of one such device - the Overbeck Rejuvenator - a 1920s electrotherapy machine designed for use by the general public. Its inventor, Otto Overbeck, was not a medical man and this enabled him to use aggressive strategies of newspaper advertising, using testimonials to market his product alongside appeals to his own scientific authority. He commissioned the prestigious Ediswan Company to manufacture the Rejuvenator on a large scale, and took out patents in eleven countries to persuade users of the efficacy of the device. In response to Overbeck's activities, the British Medical Association enlisted an electrical engineer to examine the Rejuvenator, contacted practitioners whose endorsements were being used in publicity material, and denied Overbeck permission to advertise in the British Medical Journal. Despite this, the Rejuvenator brought its inventor wealth and notoriety, and helped redefine the concept of 'rejuvenation', even if the professional reception of such a device was almost universally hostile. This paper shows how the marketing, patenting and publishing of Overbeck combined to persuade members of the laity to try the Rejuvenator as an alternative form of therapy, bypassing the medical profession in the process. PMID:25284892

  17. Preparation of capsules containing rejuvenators for their use in asphalt concrete.

    PubMed

    García, Alvaro; Schlangen, Erik; van de Ven, Martin; Sierra-Beltrán, Guadalupe

    2010-12-15

    Every year, there is a demand of more than 110 million metric tons of asphalt all around the world. This represents a huge amount of money and energy, from which a good part is for the preservation and renovation of the existing pavements. The problem of asphalt is that it oxidizes with time and therefore its beneficial properties disappear. Traditionally, rejuvenators spread in the road surface, are used to restore the original properties of the pavement. The problem is that, for a rejuvenator to be successful, it must penetrate the pavement surface. Furthermore, application of a rejuvenator will reduce the skid resistance of the pavement and, besides, rejuvenators have many aromatic compounds that can be harmful for the environment. To solve these problems this paper introduces a new concept in road construction: encapsulated rejuvenators. The basic principle is that when the stress in capsules embedded in the asphalt reaches a certain threshold value, the capsules break and some rejuvenator is released, restoring the original properties of the pavement. This paper will show how to prepare such capsules and how to determine their characteristics. This is one of the first steps towards intelligent pavements. PMID:20855160

  18. ESO 50th Anniversary Gala Dinner

    NASA Astrophysics Data System (ADS)

    Sirey, R.

    2012-12-01

    To formally mark the 50th anniversary of the signing of the ESO Convention, a gala dinner was held in the Munich Residenz. A brief report of the event is presented and the speeches are reproduced. The speakers were the President of the Council, Xavier Barcons; the German Minister for Education and Research, Prof. Dr Annette Schavan; the Bavarian State Minister for Science, Research and the Arts, Dr Wolfgang Heubisch; physics Nobel Laureate, Brian Schmidt; the current Director General, Tim de Zeeuw and the Chilean Minister of Foreign Affairs, Alfredo Moreno Charme.

  19. JANNAF 25th Airbreathing Propulsion Subcommittee, 37th Combustion Subcommittee and 1st Modeling and Simulation Subcommittee Joint Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Fry, Ronald S.; Becker, Dorothy L.

    2000-01-01

    Volume I, the first of three volumes, is a compilation of 24 unclassified/unlimited-distribution technical papers presented at the Joint Army-Navy-NASA-Air Force (JANNAF) 25th Airbreathing Propulsion Subcommittee, 37th Combustion Subcommittee and 1st Modeling and Simulation Subcommittee (MSS) meeting held jointly with the 19th Propulsion Systems Hazards Subcommittee. The meeting was held 13-17 November 2000 at the Naval Postgraduate School and Hyatt Regency Hotel, Monterey, California. Topics covered include: a Keynote Address on Future Combat Systems, a review of the new JANNAF Modeling and Simulation Subcommittee, and technical papers on Hyper-X propulsion development and verification; GTX airbreathing launch vehicles; Hypersonic technology development, including program overviews, fuels for advanced propulsion, ramjet and scramjet research, hypersonic test medium effects; and RBCC engine design and performance, and PDE and UCAV advanced and combined cycle engine technologies.

  20. Logging system adds value to field rejuvenation efforts

    SciTech Connect

    Peters, D.; Bartenhagen, K.; Santolamazza, A.

    1997-11-01

    As with any rejuvenation scheme, the first step is always identification and evaluation of potential producible reserves. But economic and physical factors made evaluation using traditional logging techniques problematic. The constraints that inhibited earlier logging tools have been addressed by a new, compact integrated system called Platform Express (PEX). Oil companies operating in two of the most mature producing regions of the US, the Hugoton-Panhandle Field and the Southwest Nena Lucia Field in West Texas, discuss the physical and economic advantages they are reaping using PEX technologies. Hugoton-Panhandle Field, discovered around 1920, sprawls across parts of three south-central states and has been one of the world`s largest gas producers. Despite continuing pressure declines in this aging gas giant, the entire region has undergone restoration in the last few years. In its Kansas portions, a modest oil production has almost doubled since 1990 and a steep gas decline has been completely turned around. These production gains have come from an active program of recompletions, the deepening of old holes and new drilling. The story in the southwest Nena Lucia Field is much the same. Operator Oryx Energy has been active in the field, located west of Abilene, Texas, since its discovery in the 1950s. The goal with this field is to use advanced technologies to reverse the production declines that began years ago. Such a reversal began in mid-1996 and has been sustained thus far.

  1. On interstellar accretion and the rejuvenation of white dwarfs

    NASA Technical Reports Server (NTRS)

    Truran, J. W.; Wyatt, S. P.; Starrfield, S. G.; Strittmatter, P. A.; Sparks, W. M.

    1977-01-01

    The paper investigates physical conditions which can give rise to thermonuclear runaways in the hydrogen envelopes of low-luminosity white dwarfs. Specifically, calculations are performed for white dwarfs of 0.5, 0.75, 1, and 1.25 solar masses with envelope masses in the range from 0.00001 to 0.001 solar mass and initial luminosities of 0.00001 to 0.01 times the solar value. It is found that envelope masses as low as 0.0001 solar mass are sufficient to initiate thermonuclear runaways on more massive white dwarfs with luminosities as low as about 0.001 the solar value. The runaway time scales under these conditions, typically of the order of a billion years, are comparable to the time scales for cooling of white dwarfs to these low luminosities. Since time-averaged accretion rates as low as a few times 10 to the -14th power solar mass per year are sufficient to reconstitute such envelopes, also on a time scale of several billion years, it is suggested that the association of novalike events with binary systems may not be unique. Accretion of interstellar matter onto isolated white dwarfs may, under some circumstances, be sufficient to rekindle and perhaps rejuvenate the dwarf. Such evolutionary behavior might define a new and distinct class of objects.

  2. The rejuvenating effect of pregnancy on muscle regeneration

    PubMed Central

    Falick Michaeli, Tal; Laufer, Neri; Sagiv, Jitka Yehudit; Dreazen, Avigail; Granot, Zvi; Pikarsky, Eli; Bergman, Yehudit; Gielchinsky, Yuval

    2015-01-01

    Aging is characterized by reduced tissue regenerative capacity attributed to a diminished responsiveness of tissue-specific stem cells. With increasing age, resident precursor cells in muscle tissues show a markedly impaired propensity to proliferate in response to damage. However, exposure to factors present in the serum of young mice restores the regenerative capacity of aged precursor cells. As pregnancy represents a unique biological model of a partially shared blood system between young and old organisms, we hypothesized that pregnancy in aged mice would have a rejuvenating effect on the mother. To test this hypothesis, we assessed muscle regeneration in response to injury in young and aged pregnant and nonpregnant mice. Muscle regeneration in the aged pregnant mice was improved relative to that in age-matched nonpregnant mice. The beneficial effect of pregnancy was transient, lasting up to 2 months after delivery, and appeared to be attributable to activation of satellite cells via the Notch signaling pathway, thus supporting the possibility that pregnancy induces activation of aged dormant muscle progenitor cells. PMID:25773509

  3. Scientific overview of hormone treatment used for rejuvenation.

    PubMed

    Morley, John E

    2013-06-01

    A search for a hormonal fountain of youth has been hotly pursued over the last century, predominately by those who wish to market hormones to a gullible public. There is little or no benefit of hormone replacement in persons who do not have a hormone deficiency. Overall, the present state of the art suggests that the findings have been disappointing. In persons who fail to get adequate sunlight, and therefore have low vitamin D levels, vitamin D replacement appears to have positive effects, including decreasing mortality. Testosterone in hypogonadal males has a number of positive effects such as improving libido and erectile capacity, increasing strength and bone mineral density, and perhaps having a small effect on cognition. These effects need to be balanced against long-term side effects, the evidence for which studies are lacking. There is little evidence to recommend DHEA, pregnenolone, growth hormone, ghrelin, or melatonin to older persons. Overall, exercise, adequate exposure to sunlight, and adequate dietary protein appear to have at least as positive an effect as any of the hormones being used to rejuvenate older persons. PMID:23726254

  4. Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria.

    PubMed

    Agrawal, Anurag; Mabalirajan, Ulaganathan

    2016-01-15

    Altered bioenergetics with increased mitochondrial reactive oxygen species production and degradation of epithelial function are key aspects of pathogenesis in asthma and chronic obstructive pulmonary disease (COPD). This motif is not unique to obstructive airway disease, reported in related airway diseases such as bronchopulmonary dysplasia and parenchymal diseases such as pulmonary fibrosis. Similarly, mitochondrial dysfunction in vascular endothelium or skeletal muscles contributes to the development of pulmonary hypertension and systemic manifestations of lung disease. In experimental models of COPD or asthma, the use of mitochondria-targeted antioxidants, such as MitoQ, has substantially improved mitochondrial health and restored respiratory function. Modulation of noncoding RNA or protein regulators of mitochondrial biogenesis, dynamics, or degradation has been found to be effective in models of fibrosis, emphysema, asthma, and pulmonary hypertension. Transfer of healthy mitochondria to epithelial cells has been associated with remarkable therapeutic efficacy in models of acute lung injury and asthma. Together, these form a 3R model--repair, reprogramming, and replacement--for mitochondria-targeted therapies in lung disease. This review highlights the key role of mitochondrial function in lung health and disease, with a focus on asthma and COPD, and provides an overview of mitochondria-targeted strategies for rejuvenating cellular respiration and optimizing respiratory function in lung diseases. PMID:26566906

  5. The Impracticality of Biomedical Rejuvenation Therapies: Translational and Pharmacological Barriers

    PubMed Central

    2014-01-01

    Abstract Editor's Note: A response to this article from Aubrey de Grey, Editor-in-Chief, can be found on pages 397–400 in this issue. The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical “repair-oriented” approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the final result impossible to predict. Two relatively easy-to-research areas are the search for successful cross-link breakers and an effective lysosomal degradation therapy. A more complex and speculative strategy is whole-body interdiction of lengthening of telomeres (WILT). Highlighting these as examples, I argue that it is unlikely that such rejuvenation biotechnologies will be used meaningfully by the general public. The discussion assumes that although such therapies may in theory one day be developed in the laboratory, and even possibly be formulated as physical clinical therapies, these will be unusable in practical terms when applied upon humans at large. Due to inherent characteristics of our biological, evolutionary, and psychological heritage, it is implausible that curing aging will occur by using physical interventions alone. PMID:25072550

  6. The impracticality of biomedical rejuvenation therapies: translational and pharmacological barriers.

    PubMed

    Kyriazis, Marios

    2014-08-01

    The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical "repair-oriented" approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the final result impossible to predict. Two relatively easy-to-research areas are the search for successful cross-link breakers and an effective lysosomal degradation therapy. A more complex and speculative strategy is whole-body interdiction of lengthening of telomeres (WILT). Highlighting these as examples, I argue that it is unlikely that such rejuvenation biotechnologies will be used meaningfully by the general public. The discussion assumes that although such therapies may in theory one day be developed in the laboratory, and even possibly be formulated as physical clinical therapies, these will be unusable in practical terms when applied upon humans at large. Due to inherent characteristics of our biological, evolutionary, and psychological heritage, it is implausible that curing aging will occur by using physical interventions alone. PMID:25072550

  7. Rejuvenation of the lithosphere by the Hawaiian plume.

    PubMed

    Li, Xueqing; Kind, Rainer; Yuan, Xiaohui; Wölbern, Ingo; Hanka, Winfried

    2004-02-26

    The volcanism responsible for creating the chain of the Hawaiian islands and seamounts is believed to mark the passage of the oceanic lithosphere over a mantle plume. In this picture hot material rises from great depth within a fixed narrow conduit to the surface, penetrating the moving lithosphere. Although a number of models describe possible plume-lithosphere interactions, seismic imaging techniques have not had sufficient resolution to distinguish between them. Here we apply the S-wave 'receiver function' technique to data of three permanent seismic broadband stations on the Hawaiian islands, to map the thickness of the underlying lithosphere. We find that under Big Island the lithosphere is 100-110 km thick, as expected for an oceanic plate 90-100 million years old that is not modified by a plume. But the lithosphere thins gradually along the island chain to about 50-60 km below Kauai. The width of the thinning is about 300 km. In this zone, well within the larger-scale topographic swell, we infer that the rejuvenation model (where the plume thins the lithosphere) is operative; however, the larger-scale topographic swell is probably supported dynamically. PMID:14985758

  8. Clinical Study of the Necessity of Replanning Before the 25th Fraction During the Course of Intensity-Modulated Radiotherapy for Patients With Nasopharyngeal Carcinoma

    SciTech Connect

    Wang Wei; Yang Haihua; Hu Wei; Shan Guoping; Ding Weijun; Yu Changhui; Wang Biyun; Wang Xufeng; Xu Qianyi

    2010-06-01

    Purpose: To quantify the target and normal structures on dose distributing variations during intensity-modulated radiotherapy (IMRT) and to assess the value of replanning for nasopharyngeal carcinoma (NPC) patients. Methods and Materials: Twenty-eight NPC patients treated with IMRT were recruited. The IMRT was delivered in 33 fractions, to 70 to 76Gy, to the gross tumor volume (GTV). Before the 25th fraction of IMRT, a new simulation computed tomography (CT) scan was acquired for all patients. According to the dose constraint criterion in the Radiation Therapy Oncology Group (RTOG) 0225 protocol, the replanning was generated on the new simulation CT. With the Quality Assessment Center of a CORVUS 6.3 treatment planning system, a phantom plan was generated for each patient by applying the beam configurations of the initial plan to the anatomy of the new simulation CT. The dose-volume histograms of the phantom plan were compared with the replanning. Results: The percentage of prescription dose delivered to the clinical target volume (CTV1) was significantly increased by 4.91% +- 10.89%, whereas the maximum dose to the spinal cord, mean dose to the left parotid, and V30 to the right parotid were significantly decreased by 5.00 +- 9.23Gy, 4.23 +- 10.03Gy, and 11.47% +- 18.89% respectively in the replanning, compared with the phantom plan (p < 0.05). Based on the dose constraint criterion in the RTOG0225 protocol, 50% of phantom plans (14/28) were out of limit for the dose to the normal critical structures, whereas no plan was out of limit in replanning (p < 0.001). Conclusion: Replanning for patients with NPC before the 25th fraction during IMRT helps to ensure adequate dose to the target volumes and safe doses to critical normal structures.

  9. Proteomic profiling of proteins associated with the rejuvenation of Sequoia sempervirens (D. Don) Endl

    PubMed Central

    2010-01-01

    Background Restoration of rooting competence is important for rejuvenation in Sequoia sempervirens (D. Don) Endl and is achieved by repeatedly grafting Sequoia shoots after 16 and 30 years of cultivation in vitro. Results Mass spectrometry-based proteomic analysis revealed three proteins that differentially accumulated in different rejuvenation stages, including oxygen-evolving enhancer protein 2 (OEE2), glycine-rich RNA-binding protein (RNP), and a thaumatin-like protein. OEE2 was found to be phosphorylated and a phosphopeptide (YEDNFDGNSNVSVMVpTPpTDK) was identified. Specifically, the protein levels of OEE2 increased as a result of grafting and displayed a higher abundance in plants during the juvenile and rejuvenated stages. Additionally, SsOEE2 displayed the highest expression levels in Sequoia shoots during the juvenile stage and less expression during the adult stage. The expression levels also steadily increased during grafting. Conclusion Our results indicate a positive correlation between the gene and protein expression patterns of SsOEE2 and the rejuvenation process, suggesting that this gene is involved in the rejuvenation of Sequoia sempervirens. PMID:21143964

  10. Investigation of the possibility of using waste cooking oil as a rejuvenating agent for aged bitumen.

    PubMed

    Zargar, Majid; Ahmadinia, Esmaeil; Asli, Hallizza; Karim, Mohamed Rehan

    2012-09-30

    The ageing of the bitumen during storage, mixing, transport and laying on the road, as well as in service life, are the most important problems presented by the use of bitumen in pavements. This paper investigates the possibility of using waste cooking oil (WCO), which is a waste material that pollutes landfills and rivers, as an alternative natural rejuvenating agent for aged bitumen to a condition that resembles the original bitumen. With this target, the physical and chemical properties of the original bitumen, aged bitumen and rejuvenated bitumen were measured and compared by the bitumen binder tests - softening point, penetration, Brookfield viscosity, dynamic shear rheometer and Fourier transform infrared spectroscopy. In addition, the behaviour of the WCO rejuvenated bitumen is investigated and compared with virgin bitumen after using the rolling thin film oven ageing process. In general, the results showed that using 3-4% of WCO the aged bitumen group 40/50 was rejuvenated to a condition that closely resembled the physical, rheological properties of the original bitumen (80/100), however, there was a difference in the tendency to ageing between the WCO rejuvenated bitumen and the virgin bitumen during mixing, transport and laying on the road. PMID:22818590

  11. Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

    PubMed Central

    Vazquez-Martin, Alejandro; Van den Haute, Chris; Cufí, Sílvia; Corominas-Faja, Bruna; Cuyàs, Elisabet; Lopez-Bonet, Eugeni; Rodriguez-Gallego, Esther; Fernández-Arroyo, Salvador; Joven, Jorge; Baekelandt, Veerle; Menendez, Javier A.

    2016-01-01

    Our understanding on how selective mitochondrial autophagy, or mitophagy, can sustain the archetypal properties of stem cells is incomplete. PTEN-induced putative kinase 1 (PINK1) plays a key role in the maintenance of mitochondrial morphology and function and in the selective degradation of damaged mitochondria by mitophagy. Here, using embryonic fibroblasts from PINK1 gene-knockout (KO) mice, we evaluated whether mitophagy is a causal mechanism for the control of cell-fate plasticity and maintenance of pluripotency. Loss of PINK1-dependent mitophagy was sufficient to dramatically decrease the speed and efficiency of induced pluripotent stem cell (iPSC) reprogramming. Mitophagy-deficient iPSC colonies, which were characterized by a mixture of mature and immature mitochondria, seemed unstable, with a strong tendency to spontaneously differentiate and form heterogeneous populations of cells. Although mitophagy-deficient iPSC colonies normally expressed pluripotent markers, functional monitoring of cellular bioenergetics revealed an attenuated glycolysis in mitophagy-deficient iPSC cells. Targeted metabolomics showed a notable alteration in numerous glycolysis- and TCA-related metabolites in mitophagy-deficient iPSC cells, including a significant decrease in the intracellular levels of α-ketoglutarate -a key suppressor of the differentiation path in stem cells. Mitophagy-deficient iPSC colonies exhibited a notably reduced teratoma-initiating capacity, but fully retained their pluripotency and multi-germ layer differentiation capacity in vivo. PINK1-dependent mitophagy pathway is an important mitochondrial switch that determines the efficiency and quality of somatic reprogramming. Mitophagy-driven mitochondrial rejuvenation might contribute to the ability of iPSCs to suppress differentiation by directing bioenergetic transition and metabolome remodeling traits. These findings provide new insights into how mitophagy might influence the stem cell decisions to retain

  12. Rejuvenation of metallic glasses by non-affine thermal strain.

    PubMed

    Ketov, S V; Sun, Y H; Nachum, S; Lu, Z; Checchi, A; Beraldin, A R; Bai, H Y; Wang, W H; Louzguine-Luzgin, D V; Carpenter, M A; Greer, A L

    2015-08-13

    When a spatially uniform temperature change is imposed on a solid with more than one phase, or on a polycrystal of a single, non-cubic phase (showing anisotropic expansion-contraction), the resulting thermal strain is inhomogeneous (non-affine). Thermal cycling induces internal stresses, leading to structural and property changes that are usually deleterious. Glasses are the solids that form on cooling a liquid if crystallization is avoided--they might be considered the ultimate, uniform solids, without the microstructural features and defects associated with polycrystals. Here we explore the effects of cryogenic thermal cycling on glasses, specifically metallic glasses. We show that, contrary to the null effect expected from uniformity, thermal cycling induces rejuvenation, reaching less relaxed states of higher energy. We interpret these findings in the context that the dynamics in liquids become heterogeneous on cooling towards the glass transition, and that there may be consequent heterogeneities in the resulting glasses. For example, the vibrational dynamics of glassy silica at long wavelengths are those of an elastic continuum, but at wavelengths less than approximately three nanometres the vibrational dynamics are similar to those of a polycrystal with anisotropic grains. Thermal cycling of metallic glasses is easily applied, and gives improvements in compressive plasticity. The fact that such effects can be achieved is attributed to intrinsic non-uniformity of the glass structure, giving a non-uniform coefficient of thermal expansion. While metallic glasses may be particularly suitable for thermal cycling, the non-affine nature of strains in glasses in general deserves further study, whether they are induced by applied stresses or by temperature change. PMID:26268190

  13. Rejuvenating Muscle Stem Cell Function: Restoring Quiescence and Overcoming Senescence.

    PubMed

    Mendelsohn, Andrew R; Larrick, James W

    2016-04-01

    Elderly humans gradually lose strength and the capacity to repair skeletal muscle. Skeletal muscle repair requires functional skeletal muscle satellite (or stem) cells (SMSCs) and progenitor cells. Diminished stem cell numbers and increased dysfunction correlate with the observed gradual loss of strength during aging. Recent reports attribute the loss of stem cell numbers and function to either increased entry into a presenescent state or the loss of self-renewal capacity due to an inability to maintain quiescence resulting in stem cell exhaustion. Earlier work has shown that exposure to factors from blood of young animals and other treatments could restore SMSC function. However, cells in the presenescent state are refractory to the beneficial effects of being transplanted into a young environment. Entry into the presenescent state results from loss of autophagy, leading to increased ROS and epigenetic modification at the CDKN2A locus due to decreased H2Aub, upregulating cell senescence biomarker p16ink4a. However, the presenescent SMSCs can be rejuvenated by agents that stimulate autophagy, such as the mTOR inhibitor rapamycin. Autophagy plays a critical role in SMSC homeostasis. These results have implications for the development of senolytic therapies that attempt to destroy p16ink4a expressing cells, since such therapies would also destroy a reservoir of potentially rescuable regenerative stem cells. Other work suggests that in humans, loss of SMSC self-renewal capacity is primarily due to decreased expression of sprouty1. DNA hypomethylation at the SPRY1 gene locus downregulates sprouty1, causing inability to maintain quiescence and eventual exhaustion of the stem cell population. A unifying hypothesis posits that in aging humans, first loss of quiescence occurs, depleting the stem cell population, but that remaining SMSCs are increasingly subject to presenescence in the very old. PMID:27000748

  14. Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate.

    PubMed

    Vazquez-Martin, Alejandro; Van den Haute, Chris; Cufí, Sílvia; Corominas-Faja, Bruna; Cuyàs, Elisabet; Lopez-Bonet, Eugeni; Rodriguez-Gallego, Esther; Fernández-Arroyo, Salvador; Joven, Jorge; Baekelandt, Veerle; Menendez, Javier A

    2016-07-01

    Our understanding on how selective mitochondrial autophagy, or mitophagy, can sustain the archetypal properties of stem cells is incomplete. PTEN-induced putative kinase 1 (PINK1) plays a key role in the maintenance of mitochondrial morphology and function and in the selective degradation of damaged mitochondria by mitophagy. Here, using embryonic fibroblasts fromPINK1 gene-knockout (KO) mice, we evaluated whether mitophagy is a causal mechanism for the control of cell-fate plasticity and maintenance of pluripotency. Loss of PINK1-dependent mitophagy was sufficient to dramatically decrease the speed and efficiency of induced pluripotent stem cell (iPSC) reprogramming. Mitophagy-deficient iPSC colonies, which were characterized by a mixture of mature and immature mitochondria, seemed unstable, with a strong tendency to spontaneously differentiate and form heterogeneous populations of cells. Although mitophagy-deficient iPSC colonies normally expressed pluripotent markers, functional monitoring of cellular bioenergetics revealed an attenuated glycolysis in mitophagy-deficient iPSC cells. Targeted metabolomics showed a notable alteration in numerous glycolysis- and TCA-related metabolites in mitophagy-deficient iPSC cells, including a significant decrease in the intracellular levels of α-ketoglutarate -a key suppressor of the differentiation path in stem cells. Mitophagy-deficient iPSC colonies exhibited a notably reduced teratoma-initiating capacity, but fully retained their pluripotency and multi-germ layer differentiation capacity in vivo. PINK1-dependent mitophagy pathway is an important mitochondrial switch that determines the efficiency and quality of somatic reprogramming. Mitophagy-driven mitochondrial rejuvenation might contribute to the ability of iPSCs to suppress differentiation by directing bioenergetic transition and metabolome remodeling traits. These findings provide new insights into how mitophagy might influence the stem cell decisions to retain

  15. Rejuvenating Hydrator: Restoring Epidermal Hyaluronic Acid Homeostasis With Instant Benefits.

    PubMed

    Narurkar, Vic A; Fabi, Sabrina G; Bucay, Vivian W; Tedaldi, Ruth; Downie, Jeanine B; Zeichner, Joshua A; Butterwick, Kimberly; Taub, Amy; Kadoya, Kuniko; Makino, Elizabeth T; Mehta, Rahul C; Vega, Virginia L

    2016-01-01

    Skin aging is a combination of multifactorial mechanisms that are not fully understood. Intrinsic and extrinsic factors modulate skin aging, activating distinctive processes that share similar molecular pathways. One of the main characteristics of youthful skin is its large capacity to retain water, and this decreases significantly as we age. A key molecule involved in maintaining skin hydration is hyaluronic acid (HA). Concentration of HA in the skin is determined by the complex balance between its synthesis, deposition, association with cellular structures, and degradation. HA bio-equivalency and bio-compatibility have been fundamental in keeping this macromolecule as the favorite of the skincare industry for decades. Scientific evidence now shows that topically applied HA is unable to penetrate the skin and is rapidly degraded on the skin surface. SkinMedica's HA5 Rejuvenating Hydrator (SkinMedica Inc., an Allergan company, Irvine, CA) promotes restoration of endogenous epidermal HA homeostasis and provides instant smoothing and hydration of the skin. These dual benefits are accomplished through the combination of 2 breakthrough technologies: 1) a unique blend of actives powered by SkinMedica proprietary flower-derived stem cell extract that restores the endogenous production of HA; and 2) a proprietary mix of 5 HA forms that plump the skin, decreasing the appearance of fine lines/wrinkles. Pre-clinical studies demonstrated that HA5 induces expression of key epidermal differentiation and barrier markers as well as epidermal HA synthases. A decrease expression of hyaluronidases was also observed upon HA5 application. Initial clinical studies showed that within 15 minutes of application, HA5 instantly improves the appearance of fine lines/wrinkles and skin hydration. Subjects that continue using HA5 (for 8 weeks) demonstrated significant improvements in fine lines/wrinkles, tactile roughness, and skin hydration. In summary, the blend of these 2 key technologies

  16. Ceremony 25th birthday Cern

    SciTech Connect

    2006-05-08

    Célébration du 25ème anniversaire du Cern (jour par jour) avec discours de L.Van Hove et J.B.Adams, des interludes musicals offerts par Mme Mey et ses collègues (au debut 1.mouvement du quatuor avec piano no 3 de L.van Beethoven) Les directeurs généraux procéderont à la remise du souvenir aux membres de personnel ayant 25 années de service dans l'organisation. Un témoignage de reconnaissance est auss fait à l'interprète Mme Zwerner

  17. Ceremony 25th birthday Cern

    ScienceCinema

    None

    2011-04-25

    Célébration du 25ème anniversaire du Cern (jour par jour) avec discours de L.Van Hove et J.B.Adams, des interludes musicals offerts par Mme Mey et ses collègues (au debut 1.mouvement du quatuor avec piano no 3 de L.van Beethoven) Les directeurs généraux procéderont à la remise du souvenir aux membres de personnel ayant 25 années de service dans l'organisation. Un témoignage de reconnaissance est auss fait à l'interprète Mme Zwerner

  18. 25th Birthday Cern- Restaurant

    ScienceCinema

    None

    2011-04-25

    Cérémonie du 25ème anniversaire du Cern avec plusieurs orateurs et la présence de nombreux autorités cantonales et communales genevoises et personnalités, directeurs généraux, ministres, chercheurs.... Le conseiller féderal et chef du département des affaires étrangères de la confédération Monsieur Pierre Aubert prend la parole pour célébrer à la fois les résultats très remarquables de la coopération internationale en matière scientifique, mais aussi la volonté politique des états européens de mettre en commun leurs ressources pour faire oeuvre d'avenir. Un grand hommage est aussi donné aux deux directeurs disparus, les prof.Bakker et Gregory.

  19. 25th Birthday Cern- Amphi

    ScienceCinema

    None

    2011-04-25

    Cérémonie du 25ème anniversaire du Cern avec 2 orateurs: le Prof.Weisskopf parle de la signification et le rôle du Cern et le Prof.Casimir(?) fait un exposé sur les rélations entre la science pure et la science appliquée et la "big science" (science légère)

  20. Views of the Apollo 11 Twentieth Anniversary Black Tie reception

    NASA Technical Reports Server (NTRS)

    1989-01-01

    View from the Apollo 11 Twentieth Anniversary Black Tie reception at the downtown Houston Hyatt Regency Hotel. Scene show NASA/JSC Director Aaron Cohen talking with NASA Administrator Richard H. Truly and his wife, Cody.

  1. Administrator Bolden Talks to Station Crew on 10th Anniversary

    NASA Video Gallery

    NASA Administrator Charlie Bolden talks with the Expedition 25 crew on board the International Space Station on November 2, marking the tenth anniversary of continuous human presence on the orbitin...

  2. 158. View looking SE showing 'Centennial Anniversary of the Declaration ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    158. View looking SE showing 'Centennial Anniversary of the Declaration of Independence' fountain on Aquarium Drive with north facade of Art Museum in right background. - Fairmount Waterworks, East bank of Schuylkill River, Aquarium Drive, Philadelphia, Philadelphia County, PA

  3. The reinforcement and healing of asphalt mastic mixtures by rejuvenator encapsulation in alginate compartmented fibres

    NASA Astrophysics Data System (ADS)

    Tabaković, A.; Post, W.; Cantero, D.; Copuroglu, O.; Garcia, S. J.; Schlangen, E.

    2016-08-01

    This paper explores the potential use of compartmented alginate fibres as a new method of incorporating rejuvenators into asphalt pavement mixtures. The compartmented fibres are employed to locally distribute the rejuvenator and to overcome the problems associated with spherical capsules and hollow fibres. The work presents proof of concept of the encapsulation process which involved embedding the fibres into the asphalt mastic mixture and the survival rate of fibres in the asphalt mixture. To prove the effectiveness of the alginate as a rejuvenator encapsulating material and to demonstrate its ability survive asphalt production process, the fibres containing the rejuvenator were prepared and subjected to thermogravimetric analysis and uniaxial tensile test. The test results demonstrated that fibres have suitable thermal and mechanical strength to survive the asphalt mixing and compaction process. The CT scan of an asphalt mortar mix containing fibres demonstrated that fibres are present in the mix in their full length, undamaged, providing confirmation that the fibres survived the asphalt production process. In order to investigate the fibres physiological properties and ability to release the rejuvenator into cracks in the asphalt mastic, the environmental scanning electron microscope and optical microscope analysis were employed. To prove its success as an asphalt healing system, compartmented alginate fibres containing rejuvenator were embedded in asphalt mastic mix. The three point bend tests were performed on the asphalt mastic test samples and the degree to which the samples began to self-heal in response was measured and quantified. The research findings indicate that alginate fibres present a promising new approach for the development of self-healing asphalt pavement systems.

  4. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong poses for a photograph with fans who attended the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

  5. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong talks with a former Apollo team member during an anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

  6. Comprehensive periorbital rejuvenation with resorbable endotine implants for trans-lid brow and midface elevation.

    PubMed

    Sclafani, Anthony P

    2007-05-01

    Periorbital rejuvenation can enhance a patient's appearance, with changes of only a few millimeters making a significant impact. Many patients undergoing blepharoplasty often have mild brow or midfacial changes for which they are unwilling to undergo additional concurrent forehead or midface procedures, however, because these procedures may be associated with an unacceptable postoperative recovery and may not provide adequate tissue fixation. This article describes limited incision procedures capable of providing excellent elevation and support to the brow and midface that can be incorporated easily into a comprehensive periorbital rejuvenation treatment plan using semi-permanent subperiosteal fixation devices. PMID:17544943

  7. Preparation and Characterization of a Monoclonal Antibody Against the Core Protein VP7 of the 25th Serotype of Bluetongue Virus

    PubMed Central

    Wu, Xiao; Liu, Qi; He, Jia; Zang, Mingxin; Wang, Haixiu; Li, Yijing

    2015-01-01

    Bluetongue virus (BTV) is a member of the genus Orbivirus, within the family Reoviridae. The VP7 protein of BTV is used for developing group-specific serological assays. To prepare monoclonal antibody (MAb) against VP7 of the 25th serotype BTV, the RNA S7 encoding VP7 was cloned into prokaryotic expression vectors pET-28a (+) and pGEX-6P-1 to generate recombinant plasmids. The recombinant protein VP7 was expressed in Escherichia coli BL21 (DE3), respectively. The results of SDS-PAGE revealed that the VP7 was expressed and the molecular mass of recombinant fusion protein pET-28a (+)/VP7 and pGEX-6P-1/VP7 was approximately 44 kDa and 64 kDa, respectively. The Western blot analysis indicated that the recombinant VP7 possessed good immunoreactivity. After purification, pET-28a (+)/VP7 was used to immunize BALB/c mice, while pGEX-6P-1/VP7 was used to screen for well-to-well MAb-secreting hybridomas. The hybridoma cell line 3H7 against recombinant VP7 that secreted MAbs was obtained. The isotype of 3H7 was identified as IgG1. The purification of recombinant VP7 protein and the monoclonal antibody will have potential applications on competitive ELISA format for BT-specific serum detection method. PMID:25897610

  8. Preparation and Characterization of a Monoclonal Antibody Against the Core Protein VP7 of the 25th Serotype of Bluetongue Virus.

    PubMed

    Wu, Xiao; Liu, Qi; He, Jia; Zang, Mingxin; Wang, Haixiu; Li, Yijing; Tang, Lijie

    2015-04-01

    Bluetongue virus (BTV) is a member of the genus Orbivirus, within the family Reoviridae. The VP7 protein of BTV is used for developing group-specific serological assays. To prepare monoclonal antibody (MAb) against VP7 of the 25th serotype BTV, the RNA S7 encoding VP7 was cloned into prokaryotic expression vectors pET-28a (+) and pGEX-6P-1 to generate recombinant plasmids. The recombinant protein VP7 was expressed in Escherichia coli BL21 (DE3), respectively. The results of SDS-PAGE revealed that the VP7 was expressed and the molecular mass of recombinant fusion protein pET-28a (+)/VP7 and pGEX-6P-1/VP7 was approximately 44 kDa and 64 kDa, respectively. The Western blot analysis indicated that the recombinant VP7 possessed good immunoreactivity. After purification, pET-28a (+)/VP7 was used to immunize BALB/c mice, while pGEX-6P-1/VP7 was used to screen for well-to-well MAb-secreting hybridomas. The hybridoma cell line 3H7 against recombinant VP7 that secreted MAbs was obtained. The isotype of 3H7 was identified as IgG1. The purification of recombinant VP7 protein and the monoclonal antibody will have potential applications on competitive ELISA format for BT-specific serum detection method. PMID:25897610

  9. Combination visible and infrared lasers for skin rejuvenation.

    PubMed

    Lee, Min-Wei Christine

    2002-12-01

    Noninvasive techniques for skin rejuvenation are quickly being established as a new standard in the treatment of mild rhytides and overall skin toning. Multiple laser wavelengths and modalities have been tried for this procedure with varying degrees of success. These lasers include 532 nm, 585 nm, 1064 nm, 1320 nm, 1450 nm, and 1540 nm wavelengths. This study evaluates a combination technique by using a long-pulsed 532 nm potassium titanyl phosphate (KTP) laser and a long-pulsed 1064 nm Neodynium:yttrium aluminum garnet (Nd:YAG) laser, both separately and combined, for noninvasive photorejuvenation and skin toning/collagen enhancement, and establishes efficacy and degree of success. A total of 150 patients were treated with the long-pulsed KTP 532 nm (Aura; Laserscope, San Jose, CA) and long-pulsed Nd:YAG 1064 nm (Lyra; Laserscope) lasers both separately and combined. Patients included skin types I through V. The fluences varied between 7 and 15 J/cm2 at 7 to 20 ms pulse duration with a 2-mm handpiece, and 6 to 15 J/cm2 and 30 to 50 ms with a 4-mm handpiece for KTP. The Nd:YAG fluences were set at 24 to 30 J/cm2 for a 10-mm handpiece and 30 J/cm2 for a SmartScan Plus scanner (Laserscope, San Jose, CA). These energies were delivered at 30 to 65 ms pulse durations. All patients were treated at least 3 times and at most 6 times at monthly intervals, and were observed for up to 18 months after the last treatment. All 150 patients exhibited a mild to moderate degree of improvement in the appearance of rhytides, moderate degree of improvement in skin toning and texture, and great improvement in the reduction of redness and pigmentation. The KTP used alone was superior to the Nd:YAG laser in terms of results. The KTP and Nd:YAG laser combination was superior to either laser used alone. PMID:12512652

  10. The Human Face of Technological Change. Theme Papers from the Silver Jubilee Conference of the Australian College of Education (25th, Australian Capital Territory, Canberra, May 5-9, 1984).

    ERIC Educational Resources Information Center

    Randell, Shirley, Ed.

    Papers presented at the 25th annual conference of the Australia College of Education addressed four major themes: The Brave New World of 1984; The Communications Revolution; Being Human in a Technological Age; and Implications of the Technological Society of Education. Papers in this volume include: (1) "The Challenge of Education in the Brave New…

  11. The Quest for Excellence in Teacher Education. International Perspectives on Improving the Quality of Teacher Education. Proceedings of the World Assembly of the International Council on Education for Teaching (25th, Rio de Janeiro, Brazil, July 24-28, 1978).

    ERIC Educational Resources Information Center

    Leavitt, Howard B., Ed.; Klassen, Frank H., Ed.

    This document contains the proceedings of the 25th World Assembly of the International Council on Education for Teaching. The Assembly focused on the topic of improving teacher education on a global scale. Leading educators from every continent participated in workshops, plenary sessions, and group discussions on a variety of topics dealing with…

  12. Mathematics Education in the South Pacific. Proceedings of the Annual Conference of the Mathematics Education Research Group of Australasia Incorporated (25th, Auckland, New Zealand, July 7-10, 2002). Volume I [and] Volume II.

    ERIC Educational Resources Information Center

    Barton, Bill, Ed.; Irwin, Kathryn C., Ed.; Pfannkuch, Maxine, Ed.; Thomas, Michael O. J., Ed.

    This document contains the proceedings of the 25th annual conference of the Mathematics Education Research Group of Australia (MERGA) held at the University of Auckland, New Zealand. The focus of this meeting is mathematics education in the South Pacific. Presentations are centered around the topic of numeracy in primary or elementary school.…

  13. Accumulation of free amino acids in marine diatom resting cells during rejuvenation

    NASA Astrophysics Data System (ADS)

    Chen, Changping; Li, Qingyu; Zhou, Qianqian; Sun, Lin; Zheng, Minhua; Gao, Yahui

    2014-01-01

    Many diatoms form resting stages under adverse growth conditions. These resting stages are known to rejuvenate once favorable conditions return, and resume vegetative growth after a certain lag period in which no divisions occurred, but what happens during this period remains unclear. Nitrogen uptake and the accumulation of free amino acids in Skeletonema marinoi resting cells during rejuvenation, but before cell division, were studied in laboratory cultures at different light intensities using the 15N-tracer technique. N uptake rate was higher for the rejuvenating cells at the higher light intensity. We hypothesized that the rapid and increasing N uptake at higher irradiance could enable S. marinoi to rebuild and reorganize its cell contents quickly and so dominate subsequent vegetative growth on the surficial sediment. Compared to the logarithmic growth phase and stationary phase, much higher concentrations of glycine (Gly) and histidine (His) were detected in resting cells, and His appeared to be a storage compound in S. marinoi resting cells. Compared to glutamine, glutamate had the higher 15N label enrichment under the light condition, showing a diel variation of N status during the lag period. The 15N labeled urea was detected at 36 h, compared to the urea cycle intermediates ornithine and citrulline at 30 h, indicating that urea was produced as an N reservoir due to the higher nitrogen uptake in the dark, and that the urea cycle was involved in S. marinoi resting cell rejuvenation.

  14. Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin

    PubMed Central

    Baht, Gurpreet S.; Silkstone, David; Vi, Linda; Nadesan, Puviindran; Amani, Yasha; Whetstone, Heather; Wei, Qingxia; Alman, Benjamin A.

    2015-01-01

    The capacity for tissues to repair and regenerate diminishes with age. We sought to determine the age-dependent contribution of native mesenchymal cells and circulating factors on in vivo bone repair. Here we show that exposure to youthful circulation by heterochronic parabiosis reverses the aged fracture repair phenotype and the diminished osteoblastic differentiation capacity of old animals. This rejuvenation effect is recapitulated by engraftment of young haematopoietic cells into old animals. During rejuvenation, β-catenin signalling, a pathway important in osteoblast differentiation, is modulated in the early repair process and required for rejuvenation of the aged phenotype. Temporal reduction of β-catenin signalling during early fracture repair improves bone healing in old mice. Our data indicate that young haematopoietic cells have the capacity to rejuvenate bone repair and this is mediated at least in part through β-catenin, raising the possibility that agents that modulate β-catenin can improve the pace or quality of fracture repair in the ageing population. PMID:25988592

  15. Assessment of the aging level of rejuvenated hot mixed asphalt concrete pavements

    NASA Astrophysics Data System (ADS)

    McGovern, Megan; Buttlar, William G.; Reis, Henrique

    2016-04-01

    The efficacy of asphalt rejuvenator on restoring the properties of oxidatively aged asphalt was tested via a non-collinear ultrasonic subsurface wave mixing technique modified for field use. Longitudinal transducers were mounted on angle wedges to generate subsurface dilatational waves to allow for pavement evaluation when there is only access to one side. Because in the field the asphalt concrete (AC) pavement properties (i.e., ultrasonic velocities and attenuations) are unknown, a pre-determined fixed incident angle (based on the AC mixture type) was used, which allows for practical implementation in the field. Oxidative aged AC specimens were coated with rejuvenator (10% by weight of the binder) and left to dwell for varying amounts of time. Once the dwell time reached the desired amount, the specimen was immediately ultrasonically tested. The frequency ratio, f2/f1, at which the interaction took place and the normalized nonlinear wave generation parameter, β/β0, were recorded and compared against a reference plot. It was observed that the rejuvenator had the effect of restoring the nonlinear properties to those corresponding to a virgin sample after a sufficient amount of dwell time. The ability of the rejuvenator to fully penetrate and act on the binder was observed to be dependent on the porosity and aggregate structure, and thus varied for each specimen. As a result, some portions of the binder were restored to a greater extent than others. This non-uniform nature was captured via the nonlinear ultrasonic technique.

  16. Rejuvenation of a mountain birch forest by an Epirrita autumnata (Lepidoptera: Geometridae) outbreak

    NASA Astrophysics Data System (ADS)

    Tenow, O.; Bylund, H.; Karlsson, P. S.; Hoogesteger, J.

    2004-03-01

    In 1955, the mountain birch forest in the Abisko valley of northern Sweden was defoliated by caterpillars of the moth Epirrita autumnata with death of stems of the polycormic trees as a result. Since then, some stands have recovered from surviving trees, producing new shoots while other stands became rejuvenated from basal sprouts. Usually, basal sprouting occurs after the death of whole trees or stems. In this case, extensive basal sprouting occurred in spite of only minor stem mortality. Two associated explanations to these differences were explored: (i) the abundant basal sprouting was caused by more top damage (and, hence, a reduced apical dominance) than in stands with less sprouting, (ii) this top damage was caused by a higher caterpillar density in the upper part of trees. Studies made during the outbreak and reported here confirm (i) and reject (ii) by showing that caterpillar densities were lower in the upper part of crowns than in the lower. The more extensive damage in the upper part of crowns may have several explanations. However, a specific sequence of events seemed to produce the rejuvenated stand. The sequence included a severe stress existing before the outbreak (as indicated by a decreased radial stem growth) which was increased by defoliations in two successive years. We, therefore, hypothesize that top dieback was caused by between - and within - stem competition for depleted carbohydrate resources at the expense of tree tops. The contributions of different types of sprouts to the rejuvenation and prerequisites for an outbreak to rejuvenate stands are discussed.

  17. Pedagogic Rejuvenation in Teacher Education in India: Concept in NCFTE 2009

    ERIC Educational Resources Information Center

    Nath, Baiju K.; M.S, Sheeba

    2009-01-01

    The educational scenario in India country is now passing through an era of renovation and refinement. The school education as well as higher education is included in this rejuvenation, with least consideration to teacher education. Pedagogic changes gained momentum by the inception of nation wide schemes such as MLL, DPEP, SSA and the emerging…

  18. [Sanatorium "Arkhangelskoe" celebrates 80th anniversary].

    PubMed

    Kirillov, G N

    2013-10-01

    The article is dedicated to the 80th anniversary of sanatorium "Arkhangelskoe" celebrating in October 2013. Since October 16th, 1933 sanatorium is a military health resort, in 1934 sanatorium was named for "Sanatorium for command personnel of the Red Army". In 1935-1936 such prominent commaders as V.K. Blyukher, A.I. Egorov, A.I. Kork, M.N. Tukhachevskiy, G.M.Shtern, A.V. Khrulev, I.E. Yakir took rest in the sanatorium. Today organization of treatment and diagnostic services in the sanatorium meets modern requirements of medical science. Diagnostics includes the following methods: bicycle ergometry, medical treadmills, ECG and ABP monitoring, rheoencephalography, oscillography, ultrasonic diagnosis, monitoring of lipid and carbonaceous metabolism, blood coagulation and anticoagulation, enzymes, electrolytes and also bacteriologic, immunologic and serological tests. The following treatment methotds are used: climatotherapy, clinical nutrition, exercise therapy, spa treatment, balneo- and fangotherapy. Also methods of magnetotherapy, lasertherapy, ultrasonic therapy, hyperbaric oxygenation, phytotherapy and halotherapy are used. PMID:24611299

  19. Post-fire Gully Rejuvenation - Evidence of Process Thresholds Controlled by Vegetation Disturbance

    NASA Astrophysics Data System (ADS)

    Hyde, K.; Woods, S.

    2011-12-01

    High intensity rainfall may trigger gully rejuvenation on hillslopes recently disturbed by wildfire, leading to debris-laden flows which generally contribute the majority of sediment transported in post-fire erosion events. We investigated the extent to which the occurrence of gully rejuvenation can be predicted based upon burn severity, rainfall data and basin morphometric variables. Field surveys were conducted at six Northern Rockies sites to identify occurrence of gully rejuvenation in first order catchments and to map and characterize the location of gully heads. NEXRAD and rain gage data analysis coupled with field observations characterized rainfall intensity and extent. Building on previous work we quantified burn severity using the Vegetation Disturbance Index (VDI), a continuous metric based upon Burned Area Reflectance Classification (BARC) maps derived from satellite imagery using the dNBR algorithm. GIS analysis combined the VDI with morphometric factors expected to influence hillslope stability. Gully heads marked abrupt transition in channel form. Above gully heads, channels were shallow and U-shaped with gentle transition to the hillslope and fine root hairs intact. Angular edges marked deep gully head incisions which down-cut channel floors from 0.2-0.3 to 1.0 meter or more. Any remaining roots were coarse and the hillslope transition was sharp. Gully heads were located at variable distances below the master rill head of the catchment hollow. Distances were obviously greater where live canopy remained upslope. Gully head morphology strongly suggests flow force transition and exceedance of an erosion process threshold. The variable distance of the gully head below the hollow suggest upslope controls influencing initiation point, possibly degree and spatial pattern of burn severity. Binary logistic regression revealed stronger correlation between gully rejuvenation and VDI than morphometric variables. The statistical strength using the continuous

  20. New evidence for rejuvenation of phosphorus retention capacity in EAF steel slag.

    PubMed

    Drizo, Aleksandra; Cummings, John; Weber, David; Twohig, Eamon; Druschel, Greg; Bourke, Bill

    2008-08-15

    The purpose of this research was to investigate phosphorus (P) retention capacity and rejuvenation potential of electric arc furnace (EAF) steel slag from Quebec and New Zealand (NZ) iron melter slag (IMS). Columns filled with slag materials were fed with dairy effluent and subjected to two feeding and one resting cycle(s). P retention capacities and rejuvenation potentials were determined after each feeding cycle. Elemental composition and mineralogical analysis were performed on IMS samples. Finally, chemical fractionation analysis was conducted on both NZ IMS and Quebec EAF steel slags. The results revealed that initiating a resting period in EAF steel slag filters prior to reaching their P saturation point increased the overall filter P retention capacity by 49.5 and 42.4% compared to 28% in a filter which had its resting period initiated after reaching P saturation. The rejuvenation property could play a significant role in full-scale applications by prolonging life expectancy and increasing cost efficiency. P retention and rejuvenation by NZ slag materials was negligible relative to EAF steel slag material from Quebec. Chemical fractionation analysis revealed differences between materials, indicating that the highest quantities of P were bound to Ca and Fe in EAF steel slag and to Ca and Al fractions in iron melter slag. This study also demonstrates that slag's performance is dependent on the source of the material and the steel making practices. Therefore, testing of the P adsorptive capability and, if relevant, the rejuvenation potential of individual steel mill slags, should be a prerequisite prior to their use in field applications. PMID:18767686

  1. 46 CFR 30.10-2a - Anniversary date-TB/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Anniversary date-TB/ALL. 30.10-2a Section 30.10-2a Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-2a Anniversary date—TB/ALL. The term anniversary date means the day and the month of each year,...

  2. 46 CFR 30.10-2a - Anniversary date-TB/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Anniversary date-TB/ALL. 30.10-2a Section 30.10-2a Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-2a Anniversary date—TB/ALL. The term anniversary date means the day and the month of each year,...

  3. Multidisciplinary approach for the study of an Egyptian coffin (late 22nd/early 25th dynasty): combining imaging and spectroscopic techniques.

    PubMed

    Bracci, S; Caruso, O; Galeotti, M; Iannaccone, R; Magrini, D; Picchi, D; Pinna, D; Porcinai, S

    2015-06-15

    This paper demonstrates that an educated methodology based on both non-invasive and micro invasive techniques in a two-step approach is a powerful tool to characterize the materials and stratigraphies of an Egyptian coffin, which was restored several times. This coffin, belonging to a certain Mesiset, is now located at the Museo Civico Archeologico of Bologna (inventory number MCABo EG 1963). Scholars attributed it to the late 22nd/early 25th dynasty by stylistic comparison. The first step of the diagnostic approach applied imaging techniques on the whole surface in order to select measurements spots and to unveil both original and restored areas. Images and close microscopic examination of the polychrome surface allowed selecting representative areas to be investigated in situ by portable spectroscopic techniques: X-ray Fluorescence (XRF), Fiber Optic Reflectance Spectroscopy (FORS) and Fourier Transform Infrared spectroscopy (FTIR). After the analysis of the results coming from the first step, very few selected samples were taken to clarify the stratigraphy of the polychrome layers. The first step, based on the combination of imaging and spectroscopic techniques in a totally non-invasive modality, is quite unique in the literature on Egyptian coffins and enabled us to reveal many differences in the ground layer's composition and to identify a remarkable number of pigments in the original and restored areas. This work offered also a chance to check the limitations of the non-invasive approach applied on a complex case, namely the right localization of different materials in the stratigraphy and the identification of binding media. Indeed, to dissolve any remaining doubts on superimposed layers belonging to different interventions, it was necessary to sample few micro-fragments in some selected areas and analyze them prepared as cross-sections. The original ground layer is made of calcite, while the restored areas show the presence of either a mixture of calcite

  4. Multidisciplinary approach for the study of an Egyptian coffin (late 22nd/early 25th dynasty): Combining imaging and spectroscopic techniques

    NASA Astrophysics Data System (ADS)

    Bracci, S.; Caruso, O.; Galeotti, M.; Iannaccone, R.; Magrini, D.; Picchi, D.; Pinna, D.; Porcinai, S.

    2015-06-01

    This paper demonstrates that an educated methodology based on both non-invasive and micro invasive techniques in a two-step approach is a powerful tool to characterize the materials and stratigraphies of an Egyptian coffin, which was restored several times. This coffin, belonging to a certain Mesiset, is now located at the Museo Civico Archeologico of Bologna (inventory number MCABo EG 1963). Scholars attributed it to the late 22nd/early 25th dynasty by stylistic comparison. The first step of the diagnostic approach applied imaging techniques on the whole surface in order to select measurements spots and to unveil both original and restored areas. Images and close microscopic examination of the polychrome surface allowed selecting representative areas to be investigated in situ by portable spectroscopic techniques: X-ray Fluorescence (XRF), Fiber Optic Reflectance Spectroscopy (FORS) and Fourier Transform Infrared spectroscopy (FTIR). After the analysis of the results coming from the first step, very few selected samples were taken to clarify the stratigraphy of the polychrome layers. The first step, based on the combination of imaging and spectroscopic techniques in a totally non-invasive modality, is quite unique in the literature on Egyptian coffins and enabled us to reveal many differences in the ground layer's composition and to identify a remarkable number of pigments in the original and restored areas. This work offered also a chance to check the limitations of the non-invasive approach applied on a complex case, namely the right localization of different materials in the stratigraphy and the identification of binding media. Indeed, to dissolve any remaining doubts on superimposed layers belonging to different interventions, it was necessary to sample few micro-fragments in some selected areas and analyze them prepared as cross-sections. The original ground layer is made of calcite, while the restored areas show the presence of either a mixture of calcite

  5. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong is the center of attention at the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon. He appeared at the banquet with other former astronauts Edwin 'Buzz' Aldrin, Gene Cernan, Walt Cunningham and others.

  6. Former Apollo astronauts speak at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo astronauts Neil Armstrong (left) and Gene Cernan entertain the audience during an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Edwin 'Buzz' Aldrin and Walt Cunningham. Armstrong was the first man to walk on the moon; Cernan was the last.

  7. Former Apollo astronauts speak at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo astronauts Neil Armstrong (left) and Gene Cernan entertain the audience during an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Edwin 'Buzz' Aldrin and Walt Cunningham. Neil Armstrong was the first man to walk on the moon; Gene Cernan was the last.

  8. Center Director Bridges speaks at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    At an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible, Center Director Roy D. Bridges offers remarks. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were astronauts Neil Armstrong, Edwin 'Buzz' Aldrin, Wally Schirra, Gene Cernan and Walt Cunningham. Neil Armstrong was the first man to walk on the moon; Gene Cernan was the last.

  9. Former Apollo astronauts speak at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo astronauts Edwin 'Buzz' Aldrin (left) and Gene Cernan share stories about their missions for an audience attending an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Gene Cernan and Walt Cunningham. Neil Armstrong was the first man to walk on the moon; Gene Cernan was the last.

  10. The unexpected outcomes of anti-aging, rejuvenation, and life extension studies: an origin of modern therapies.

    PubMed

    Stambler, Ilia

    2014-06-01

    The search for life-extending interventions has been often perceived as a purely academic pursuit, or as an unorthodox medical enterprise, with little or no practical outcome. Yet, in fact, these studies, explicitly aiming to prolong human life, often constituted a formidable, though hardly ever acknowledged, motivation for biomedical research and discovery. At least several modern biomedical fields have originated directly from rejuvenation and life extension research: (1) Hormone replacement therapy was born in Charles-Edouard Brown-Séquard's rejuvenation experiments with animal gland extracts (1889). (2) Probiotic diets originated in Elie Metchnikoff's conception of radically prolonged "orthobiosis" (c. 1900). (3) The development of clinical endocrinology owed much to Eugen Steinach's "endocrine rejuvenation" operations (c. 1910s-1920s). (4) Tissue transplantations in humans (allografts and xenografts) were first widely performed in Serge Voronoff's "rejuvenation by grafting" experiments (c. 1910s-1920s). (5) Tissue engineering was pioneered during Alexis Carrel's work on cell and tissue immortalization (c. 1900-1920). (6) Cell therapy (and particularly human embryonic cell therapy) was first widely conducted by Paul Niehans for the purposes of rejuvenation as early as the 1930s. Thus, the pursuit of life extension and rejuvenation has constituted an inseparable and crucial element in the history of biomedicine. Notably, the common principle of these studies was the proactive maintenance of stable, long-term homeostasis of the entire organism. PMID:24524368

  11. Fluoxetine tenth anniversary update: the progress continues.

    PubMed

    Stokes, P E; Holtz, A

    1997-01-01

    This tenth anniversary review/update of fluoxetine concentrates on the past 5 years of its clinical application. The mechanism of action of fluoxetine; its metabolism; its efficacy in patients with various diagnostic subgroups of depression, patients with coincident medical disease, children and adolescents with depression, patients with eating disorders, and patients with obsessive-compulsive disorder (OCD); its long-term (maintenance) efficacy; its side effects and toxicity; and pharmacoeconomic considerations are reviewed. Pharmacotherapy is currently the only proven method for treating major depressive disorder that is applicable to all levels of severity of major depressive illness. Since its introduction 10 years ago, fluoxetine has been available to psychiatrists, primary care physicians, and other nonpsychiatric physicians as full-dose effective pharmacotherapy for patients with depression. Fluoxetine has been widely prescribed by physicians knowledgeable in pharmacology and in the treatment of depression because of its proven efficacy (ie, equal to that of tricyclic antidepressants [TCAs]), its ease of administration (with full therapeutic dosing usually starting from day 1), its generally benign side-effect profile, its remarkable safety in over-dose, and its proven effectiveness in the most common depressed patient population--anxious, agitated, depressed patients--as well as in patients with various subtypes and severities of depression. In more recent years it has also proved effective in the treatment of bulimia, an entity for which only limited or inadequate treatment options had been previously available. In OCD, fluoxetine, with its more acceptable side-effect profile and greater ease of dosing, presents a favorable alternative to previous drug therapy and is useful in treating both obsessions and compulsions. Fluoxetine is currently recognized among clinicians as efficacious in treating anxiety disorders and is being used successfully in special

  12. CP-1 70th Anniversary Symposium

    ScienceCinema

    Len Koch; Harold Agnew

    2013-06-05

    Dr. Harold Agnew, retired director of Los Alamos National Laboratory and one of 49 people present on December 2, 1942 when the world?s first man-made controlled nuclear chain reaction was achieved with the CP-1 reactor, and Dr. Len Koch, one of Argonne?s earliest staff members and a designer of EBR-I, the first liquid metal-cooled fast reactor, spoke about their early work during ?The Dawn of the Nuclear Age?, a Director?s Special Symposium held as one of the events to commemorate the 70th anniversary year of CP-1 achieving criticality. The symposium was moderated by Dr. Charles Till, a retired Argonne associate laboratory director who led Argonne?s nuclear engineering programs throughout the 1980?s and ?90?s. Dr. Agnew painted a vivid picture of the challenges and rewards of working in Enrico Fermi?s group under strict security conditions and the complete faith all in the group had in Fermi?s analyses. He stated that no one ever doubted that CP-1 would achieve criticality, and when the moment came, those present acknowledged the accomplishment with little more than a subdued toast of chianti from a bottle provided by reactor physicist Eugene Wigner. This experimental work on nuclear reactors was continued in the Chicago area and led first by Fermi and then Walter Zinn, another member of Fermi?s CP-1 group, resulting in the formal establishment of Argonne National Laboratory on July 1, 1946. Dr. Koch described how much he enjoyed working at Argonne through the 1950?s and ?60?s and contributing to many of the research ?firsts? that Argonne achieved in the nuclear energy field and led to the foundation of the commercial nuclear power generation industry. His reminiscences about all that was achieved with EBR-I and how that work then led into Argonne?s design, building, and operation of EBR-II as a full demonstration of a fast reactor power plant brought Argonne?s nuclear energy legacy to life for everyone in the auditorium. These engaging presentations prompted a

  13. Spinoff 2002: Fortieth Anniversary Technology Utilization Program

    NASA Technical Reports Server (NTRS)

    2002-01-01

    . Each section of Spinoff 2002 provides compelling evidence of the Technology Transfer Program's success and value. With commercial products and successes spanning from work on the Apollo missions to the International Space Station, the 40th anniversary of the Technology Transfer Program invites us to celebrate our history while planning the future.

  14. The AAS Visiting Professor Programs: Three Anniversaries

    NASA Astrophysics Data System (ADS)

    Philip, A. G. Davis

    2003-05-01

    . Shapley visits have been made to Canadian institutions since 1976 and to Mexican institutions since 1998. After the summer meeting it will be the start of the 10th year of my directing the program. On May 26 there will be a Shapley Dinner at Dyer Observatory in Nashville for the Shapley lecturers who are attending the AAS meeting and we will celebrate these three anniversaries.

  15. CP-1 70th Anniversary Symposium

    SciTech Connect

    Len Koch; Harold Agnew

    2012-07-11

    Dr. Harold Agnew, retired director of Los Alamos National Laboratory and one of 49 people present on December 2, 1942 when the world’s first man-made controlled nuclear chain reaction was achieved with the CP-1 reactor, and Dr. Len Koch, one of Argonne’s earliest staff members and a designer of EBR-I, the first liquid metal-cooled fast reactor, spoke about their early work during “The Dawn of the Nuclear Age”, a Director’s Special Symposium held as one of the events to commemorate the 70th anniversary year of CP-1 achieving criticality. The symposium was moderated by Dr. Charles Till, a retired Argonne associate laboratory director who led Argonne’s nuclear engineering programs throughout the 1980’s and ‘90’s. Dr. Agnew painted a vivid picture of the challenges and rewards of working in Enrico Fermi’s group under strict security conditions and the complete faith all in the group had in Fermi’s analyses. He stated that no one ever doubted that CP-1 would achieve criticality, and when the moment came, those present acknowledged the accomplishment with little more than a subdued toast of chianti from a bottle provided by reactor physicist Eugene Wigner. This experimental work on nuclear reactors was continued in the Chicago area and led first by Fermi and then Walter Zinn, another member of Fermi’s CP-1 group, resulting in the formal establishment of Argonne National Laboratory on July 1, 1946. Dr. Koch described how much he enjoyed working at Argonne through the 1950’s and ‘60’s and contributing to many of the research “firsts” that Argonne achieved in the nuclear energy field and led to the foundation of the commercial nuclear power generation industry. His reminiscences about all that was achieved with EBR-I and how that work then led into Argonne’s design, building, and operation of EBR-II as a full demonstration of a fast reactor power plant brought Argonne’s nuclear energy legacy to life for everyone in the auditorium. These

  16. Epidermal and dermal changes in response to various skin rejuvenation methods.

    PubMed

    Helbig, D; Simon, J C; Paasch, U

    2010-12-01

    During the last years, a number of new devices have been developed to improve the dermal and epidermal signs of photo- and chronological skin ageing. There are well-established ablative and non-ablative skin resurfacing options using different lasers and light sources, but side effects have been observed frequently. A recently developed photorejuvenation method using non-thermal stimulation of skin cells with low energy and narrow band light has been termed photomodulation. Light emitting diodes are the ideal source of this kind of light that stimulate mitochondrial cell organelles leading to up-regulation of cytochrome electron transport pathway leading to mitochondrial DNA gene modulation. This paper reviews the most current knowledge of intrinsic and extrinsic changes of ageing and summarizes different systems for skin rejuvenation with focus on non-thermal non-ablative skin rejuvenation modalities. PMID:20572891

  17. Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients.

    PubMed

    Park, Kui Young; Seok, Joon; Rho, Nark Kyoung; Kim, Beom Joon; Kim, Myeung Nam

    2016-01-01

    Aging well has become the new target of preventative medicine, and aesthetic dermatology can contribute to this request. The polynucleotide (PN) containing products not only fill the space, but improve tissue regeneration, resulting in more natural tissue regeneration. Five Korean women received four times injections of long-chain PN filler in two-week intervals for skin rejuvenation. About 0.05 mL of material was injected in 40 points of one-side cheek. The pore and skin thickness were markedly improved in the patients in their 30s, whereas skin tone, melanin, wrinkles, and sagging were noticeably improved for patients in their 40s. There are no serious side effects. In conclusion, intradermal long-chain PN filler injection seems to be an effective and safe treatment for skin rejuvenation. PMID:26814448

  18. Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment.

    PubMed

    Cao, Wenluo; Li, Lingna; Kajiura, Satoshi; Amoh, Yasuyuki; Tan, Yuying; Liu, Fang; Hoffman, Robert M

    2016-04-17

    We demonstrate in the present study that young host mice rejuvenate aged hair follicles after transplantation. Young mice promote the hair shaft growth of transplanted old hair follicles, as well as young follicles, in contrast to old host mice, which did not support hair-shaft growth from transplanted old or young follicles. Nestin-expressing hair follicle-associated pluripotent (HAP) stem cells of transplanted old and young hair follicles remained active in young host nude mice. In contrast, the nestin-expressing HAP stem cells in young and old hair follicles transplanted to old nude mice were not as active as in young nude host mice. The present study shows that transplanted old hair follicles were rejuvenated by young host mice, suggesting that aging may be reversible. PMID:26940664

  19. The evolution of wrinkle removal: use of lasers and other devices in facial rejuvenation.

    PubMed

    Tholen, Richard H

    2012-06-01

    Lasers have revolutionized facial rejuvenation. Various wavelengths, more powerful machines allowing shorter shutter times and more precise vaporization, and other innovations led physicians and their patients to embrace ablative laser technology. The results have not always been positive, however. Over-adoption by poorly trained physicians led to highly publicized problems and the development of a whole class of nonablative machines as well as fractional laser technology. This article reviews the evolution of wrinkle removal by lasers and other devices. PMID:22866499

  20. Facial rejuvenation for middle-aged women: a combined approach with minimally invasive procedures

    PubMed Central

    Goldman, Alberto; Wollina, Uwe

    2010-01-01

    Facial rejuvenation is a significant process involved in restoring youthfulness. The introduction of less invasive procedures has increased acceptance of such procedures. Often a combination of different techniques allows individualized treatment with optimal outcomes. Furthermore, this leads to a natural look without a significant downtime. We report herein the use of such a combined approach in middle-aged women with particular emphasis on botulinum toxin type A, dermal fillers, and chemical peels. PMID:20924438

  1. Quantitative evaluation of rejuvenators to restore embrittlement temperatures in oxidized asphalt mixtures using acoustic emission

    NASA Astrophysics Data System (ADS)

    Sun, Zhe; Farace, Nicholas; Arnold, Jacob; Behnia, Behzad; Buttlar, William G.; Reis, Henrique

    2015-03-01

    Towards developing a method capable to assess the efficiency of rejuvenators to restore embrittlement temperatures of oxidized asphalt binders towards their original, i.e., unaged values, three gyratory compacted specimens were manufactured with mixtures oven-aged for 36 hours at 135 °C. In addition, one gyratory compacted specimen manufactured using a short-term oven-aged mixture for two hours at 155 °C was used for control to simulate aging during plant production. Each of these four gyratory compacted specimens was then cut into two cylindrical specimen 5 cm thick for a total of six 36-hour oven-aged specimens and two short term aging specimens. Two specimens aged for 36 hours and the two short-term specimens were then tested using an acoustic emission approach to obtain base acoustic emission response of short-term and severely-aged specimens. The remaining four specimens oven-aged for 36 hours were then treated by spreading their top surface with rejuvenator in the amount of 10% of the binder by weight. These four specimens were then tested using the same acoustic emission approach after two, four, six, and eight weeks of dwell time. It was observed that the embrittlement temperatures of the short-term aged and severely oven-aged specimens were -25 °C and - 15 °C, respectively. It was also observed that after four weeks of dwell time, the rejuvenator-treated samples had recuperated the original embrittlement temperatures. In addition, it was also observed that the rejuvenator kept acting upon the binder after four weeks of dwell time; at eight weeks of dwell time, the specimens had an embrittlement temperature about one grade cooler than the embrittlement temperature corresponding to the short-term aged specimen.

  2. Rejuvenation of stellar mergers and the origin of magnetic fields in massive stars

    NASA Astrophysics Data System (ADS)

    Schneider, F. R. N.; Podsiadlowski, Ph.; Langer, N.; Castro, N.; Fossati, L.

    2016-04-01

    Approximately 10 per cent of massive OBA main-sequence (MS) and pre-MS stars harbour strong, large-scale magnetic fields. At the same time, there is a dearth of magnetic stars in close binaries. A process generating strong magnetic fields only in some stars must be responsible with the merging of pre-MS and MS stars being suggested as one such channel. Stars emerging from the coalescence of two MS stars are rejuvenated, appearing younger than they are. They can therefore be identified by comparison with reference clocks. Here, we predict the rejuvenation of MS merger products over a wide range of masses and binary configurations calibrated to smoothed-particle-hydrodynamical merger models. We find that the rejuvenation is of the order of the nuclear time-scale and is strongest in the lowest mass mergers and the most evolved binary progenitors with the largest mass ratios. These predictions allow us to put constraints on the binary progenitors of merger products. We show that the magnetic stars HR 2949 and τ Sco are younger than the potential binary companion HR 2948 and the Upper-Sco association, respectively, making them promising merger candidates. We find that the age discrepancies and the potential binary progenitors of both are consistent with them being rejuvenated merger products, implying that their magnetic fields may originate from this channel. Searching for age discrepancies in magnetic stars is therefore a powerful way to explore which fraction of magnetic stars may have obtained their strong magnetic field in MS mergers and to improve our understanding of magnetism in massive stars and their remnants.

  3. Assessment of service induced microstructural damage and its rejuvenation in turbine blades

    NASA Astrophysics Data System (ADS)

    Koul, A. K.; Castillo, R.

    1988-08-01

    Correlations between service induced microstructural degradation and creep properties in investment cast IN738LC turbine blades are discussed. Microstructural degradation in the form of γ’ coarsen-ing, MC carbide degeneration, formation of continuous networks of grain boundary M23C6 carbides, and the disappearance of serrated grain boundaries are considered in some detail. Their influence on primary ( t p ,ɛ p ), secondary ( t s , ɛ s ,ɛ m ) and tertiary (tt, ɛt) creep behavior is analyzed through rela-tionships of the form: left( {{t_p + t_s }/{\\varepsilon _p + \\varepsilon _s }} right)dot \\varepsilon _m = K(Initial transient behavior) begin{gathered} left( {t_{t/\\varepsilon _t }^{2 33} } right)dot \\varepsilon _m = K(Intragranular creep governed \\ by γ ' interparticle spacing) \\ begin{gathered} left[ { - t_{t/(e^{ - 50_\\varepsilon } t - 1)} } right]dot \\varepsilon _m = K_2 (Intragranular creep governed \\ by mobile dislocation density) \\ and left( {t_t /\\varepsilon _t } right)dot \\varepsilon _m = K(Grain boundary cavity nucleation) These relationships are able to reveal service induced degeneration effects and can therefore be used to qualify rejuvenated blades. A systematic strategy for designing a HIPping rejuvenation cycle for Ni-base superalloys is presented. Once a rejuvenation cycle is designed, the above-mentioned relationships can then be used to analyze the extent of the rejuvenation of microstructure and creep properties in reheat-treated or hot isostatically pressed service exposed turbine blades. The influ-ence of trace amounts of Zr on creep properties of service exposed IN738LC turbine blades is also highlighted.

  4. NADEOSA 10th Anniversary Conference Formal Evaluation Report

    ERIC Educational Resources Information Center

    South African Journal of Higher Education, 2007

    2007-01-01

    NADEOSA held its 10th anniversary conference during August 2006 on the theme "Celebrating 10 years of NADEOSA. Exploring the role of ICTs in addressing educational needs: Identifying the myths and miracles." The conference evaluation strategy consisted of a number of consciously planned processes, a dialogical and reflective account which had been…

  5. Beyond Discipline: From Compliance to Community. 10th Anniversary Edition

    ERIC Educational Resources Information Center

    Kohn, Alfie

    2006-01-01

    In this 10th anniversary edition of an Association for Supervision and Curriculum Development (ASCD) best seller, the author reflects on his revolutionary ideas in the context of today's emphasis on school accountability and high-stakes testing. The author relates how his innovative approach--where teachers learn to work with students, rather than…

  6. Views of the Apollo 11 Twentieth Anniversary Black Tie reception

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Views of the Apollo 11 Twentieth Anniversary Black Tie reception at the downtown Houston Hyatt Regency Hotel. Views include former JSC Directors Robert Gilruth and Christopher C. Kraft Jr. reminiscing with keynote speaker Walter Cronkite (39934); Apollo astronauts Tom Stafford (left) and Neil Armstrong (right) talk with former Soviet cosmonaut Alexei Leonov (center) at the gala (39935).

  7. 100th Anniversary of the Juvenile Court, 1899-1999.

    ERIC Educational Resources Information Center

    Juvenile Justice, 1999

    1999-01-01

    This issue commemorates the 100th anniversary of the creation of the juvenile court and the recognition that the developmental differences between children and adults require differences in the ways they are treated by the court system. The feature article, "An Evolving Juvenile Court: On the Front Lines with Judge J. Dean Lewis," reviews the…

  8. 76 FR 26923 - 50th Anniversary of the Freedom Rides

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-09

    ... From the Federal Register Online via the Government Publishing Office ] Vol. 76 Monday, No. 89 May 9, 2011 Part V The President Proclamation 8668--50th Anniversary of the Freedom Rides #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register / Vol. 76, No. 89 / Monday, May 9, 2011 / Presidential Documents#0;#0; #0; #0;Title 3-- #0;The President ]...

  9. De Novo Assembly of the Transcriptome of Turritopsis, a Jellyfish that Repeatedly Rejuvenates.

    PubMed

    Hasegawa, Yoshinori; Watanabe, Takashi; Takazawa, Masaki; Ohara, Osamu; Kubota, Shin

    2016-08-01

    In most animals, aging is an irreversible process; however the species Turritopsis sp. has been observed to undergo a rejuvenation process as many as 14 times. In the present study, we used multiplexed RNA libraries to obtain the transcriptome from four developmental stages (St) of Turritopsis sp., including (I) immature medusa, (II) dumpling, (III) dumpling with a short stolon, and (IV) polyp, which had recently rejuvenated. A total of 4.02 billion paired-end reads were assembled de novo, yielding 90,327 contigs. Our analyses revealed that significant blast hits were recovered for 74% of the assembled contigs, and 19% were successfully annotated with gene ontology (GO) terms. A BLAST search demonstrated that 32% of the contigs were most similar to Hydra vulgarissequences. Raw reads from each sample were mapped against the contigs to find St-specific genes. This represents the first comprehensive set of de novo transcriptome data for this species, which may provide clues toward a better understanding of cyclical rejuvenation in multicellular animals. PMID:27498796

  10. Theory of Aging, Rejuvenation, and the Nonequilibrium Steady State in Deformed Polymer Glasses

    SciTech Connect

    Chen, Kang

    2010-01-01

    The nonlinear Langevin equation theory of segmental relaxation, elasticity, and mechanical response of polymer glasses is extended to describe the coupled effects of physical aging, mechanical rejuvenation, and thermal history. The key structural variable is the amplitude of density fluctuations, and segmental dynamics proceeds via stress-modified activated barrier hopping on a dynamic free-energy profile. Mechanically generated disorder rejuvenation is quantified by a dissipative work argument and increases the amplitude of density fluctuations, thereby speeding up relaxation beyond that induced by the landscape tilting mechanism. The theory makes testable predictions for the time evolution and nonequilibrium steady state of the alpha relaxation time, density fluctuation amplitude, elastic modulus, and other properties. Model calculations reveal a rich dependence of these quantities on preaging time, applied stress, and temperature that reflects the highly nonlinear competition between physical aging and mechanical disordering. Thermal history is erased in the long-time limit, although the nonequilibrium steady state is not the literal fully rejuvenated freshly quenched glass. The present work provides the conceptual foundation for a quantitative treatment of the nonlinear mechanical response of polymer glasses under a variety of deformation protocols.

  11. Development of Facial Rejuvenation Procedures: Thirty Years of Clinical Experience with Face Lifts.

    PubMed

    Kim, Byung Jun; Choi, Jun Ho; Lee, Yoonho

    2015-09-01

    Facial rejuvenation procedures can be roughly divided into face lift surgery and nonoperative, less invasive procedures, such as fat grafts, fillers, botulinum toxin injections, thread lifts, or laserbrasion. Face lift surgery or rhytidectomy is the procedure most directly associated with rejuvenation, due to its fundamental ability to restore the anatomical changes caused by aging. Various methods of face lift surgery have been developed over the last hundred years, thanks to advances in the understanding of facial anatomy and the mechanisms of aging, as well as the dedication of innovative surgeons. However, no generally applicable standard method exists, because the condition of each patient is different, and each operative method has advantages and disadvantages. Specific characteristics of the skin of Asians and their skeletal anatomy should be considered when determining the operative method to be used on Asian patients. Plastic surgeons should improve their ability to analyze the original aesthetic properties and problem areas of each patient, drawing on scientific knowledge about the aging process, and they should develop the skills necessary to perform various rejuvenative techniques. In the present article, we reviewed various face lift procedures and the current methods of modified double plane face lift, based on our clinical experience of over 30 years. PMID:26430622

  12. European expert recommendations on the use of injectable poly-L-lactic acid for facial rejuvenation.

    PubMed

    Alessio, Redaelli; Rzany, Berthold; Eve, Linda; Grangier, Yann; Herranz, Pedro; Olivier-Masveyraud, Frédérique; Vleggaar, Danny

    2014-09-01

    Over the last few years, there have been a number of important changes in how we appreciate and understand the aging face. Volume loss is now recognized as a major component of facial aging. Treatment options that replace lost volume are increasingly used for recontouring and rejuvenation of the aging face. In this review we present and discuss the European Expert Group recommendations on the ideal use of the unique collagen stimulator, poly-L-lactic acid (PLLA, Sculptra®, Sinclair Pharmaceuticals) for facial rejuvenation lasting up to 25 months. Optimal results are achieved based on a detailed knowledge of facial anatomy, correct treatment procedure, specifically the right dilution, the correct injection technique, as well as appropriate patient aftercare. PLLA is an effective and safe collagen stimulator that treats the whole face. PLLA is simple to use, provides the foundation for facial rejuvenation, is easy to combine with other treatments, and gives long-lasting effects with a high level of patient satisfaction. PMID:25226006

  13. Seismological constraints on the crustal structures generated by continental rejuvenation in northeastern China

    PubMed Central

    Zheng, Tian-Yu; He, Yu-Mei; Yang, Jin-Hui; Zhao, Liang

    2015-01-01

    Crustal rejuvenation is a key process that has shaped the characteristics of current continental structures and components in tectonic active continental regions. Geological and geochemical observations have provided insights into crustal rejuvenation, although the crustal structural fabrics have not been well constrained. Here, we present a seismic image across the North China Craton (NCC) and Central Asian Orogenic Belt (CAOB) using a velocity structure imaging technique for receiver functions from a dense array. The crustal evolution of the eastern NCC was delineated during the Mesozoic by a dominant low seismic wave velocity with velocity inversion, a relatively shallow Moho discontinuity, and a Moho offset beneath the Tanlu Fault Zone. The imaged structures and geochemical evidence, including changes in the components and ages of continental crusts and significant continental crustal growth during the Mesozoic, provide insight into the rejuvenation processes of the evolving crust in the eastern NCC caused by structural, magmatic and metamorphic processes in an extensional setting. The fossil structural fabric of the convergent boundary in the eastern CAOB indicates that the back-arc action of the Paleo-Pacific Plate subduction did not reach the hinterland of Asia. PMID:26443323

  14. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

    PubMed

    Chang, Jianhui; Wang, Yingying; Shao, Lijian; Laberge, Remi-Martin; Demaria, Marco; Campisi, Judith; Janakiraman, Krishnamurthy; Sharpless, Norman E; Ding, Sheng; Feng, Wei; Luo, Yi; Wang, Xiaoyan; Aykin-Burns, Nukhet; Krager, Kimberly; Ponnappan, Usha; Hauer-Jensen, Martin; Meng, Aimin; Zhou, Daohong

    2016-01-01

    Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI). Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders, suggesting that SCs play a causative role in certain age-related pathologies. Thus, a 'senolytic' pharmacological agent that can selectively kill SCs holds promise for rejuvenating tissue stem cells and extending health span. To test this idea, we screened a collection of compounds and identified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent senolytic drug. We show that ABT263 selectively kills SCs in culture in a cell type- and species-independent manner by inducing apoptosis. Oral administration of ABT263 to either sublethally irradiated or normally aged mice effectively depleted SCs, including senescent bone marrow hematopoietic stem cells (HSCs) and senescent muscle stem cells (MuSCs). Notably, this depletion mitigated TBI-induced premature aging of the hematopoietic system and rejuvenated the aged HSCs and MuSCs in normally aged mice. Our results demonstrate that selective clearance of SCs by a pharmacological agent is beneficial in part through its rejuvenation of aged tissue stem cells. Thus, senolytic drugs may represent a new class of radiation mitigators and anti-aging agents. PMID:26657143

  15. Development of Facial Rejuvenation Procedures: Thirty Years of Clinical Experience with Face Lifts

    PubMed Central

    Kim, Byung Jun; Choi, Jun Ho

    2015-01-01

    Facial rejuvenation procedures can be roughly divided into face lift surgery and nonoperative, less invasive procedures, such as fat grafts, fillers, botulinum toxin injections, thread lifts, or laserbrasion. Face lift surgery or rhytidectomy is the procedure most directly associated with rejuvenation, due to its fundamental ability to restore the anatomical changes caused by aging. Various methods of face lift surgery have been developed over the last hundred years, thanks to advances in the understanding of facial anatomy and the mechanisms of aging, as well as the dedication of innovative surgeons. However, no generally applicable standard method exists, because the condition of each patient is different, and each operative method has advantages and disadvantages. Specific characteristics of the skin of Asians and their skeletal anatomy should be considered when determining the operative method to be used on Asian patients. Plastic surgeons should improve their ability to analyze the original aesthetic properties and problem areas of each patient, drawing on scientific knowledge about the aging process, and they should develop the skills necessary to perform various rejuvenative techniques. In the present article, we reviewed various face lift procedures and the current methods of modified double plane face lift, based on our clinical experience of over 30 years. PMID:26430622

  16. Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain.

    PubMed

    De Jonge, Natalie; Garcia-Pino, Abel; Buts, Lieven; Haesaerts, Sarah; Charlier, Daniel; Zangger, Klaus; Wyns, Lode; De Greve, Henri; Loris, Remy

    2009-07-31

    Toxin-antitoxin modules are small regulatory circuits that ensure survival of bacterial populations under challenging environmental conditions. The ccd toxin-antitoxin module on the F plasmid codes for the toxin CcdB and its antitoxin CcdA. CcdB poisons gyrase while CcdA actively dissociates CcdB:gyrase complexes in a process called rejuvenation. The CcdA:CcdB ratio modulates autorepression of the ccd operon. The mechanisms behind both rejuvenation and regulation of expression are poorly understood. We show that CcdA binds consecutively to two partially overlapping sites on CcdB, which differ in affinity by six orders of magnitude. The first, picomolar affinity interaction triggers a conformational change in CcdB that initiates the dissociation of CcdB:gyrase complexes by an allosteric segmental binding mechanism. The second, micromolar affinity binding event regulates expression of the ccd operon. Both functions of CcdA, rejuvenation and autoregulation, are mechanistically intertwined and depend crucially on the intrinsically disordered nature of the CcdA C-terminal domain. PMID:19647513

  17. Seismological constraints on the crustal structures generated by continental rejuvenation in northeastern China.

    PubMed

    Zheng, Tian-Yu; He, Yu-Mei; Yang, Jin-Hui; Zhao, Liang

    2015-01-01

    Crustal rejuvenation is a key process that has shaped the characteristics of current continental structures and components in tectonic active continental regions. Geological and geochemical observations have provided insights into crustal rejuvenation, although the crustal structural fabrics have not been well constrained. Here, we present a seismic image across the North China Craton (NCC) and Central Asian Orogenic Belt (CAOB) using a velocity structure imaging technique for receiver functions from a dense array. The crustal evolution of the eastern NCC was delineated during the Mesozoic by a dominant low seismic wave velocity with velocity inversion, a relatively shallow Moho discontinuity, and a Moho offset beneath the Tanlu Fault Zone. The imaged structures and geochemical evidence, including changes in the components and ages of continental crusts and significant continental crustal growth during the Mesozoic, provide insight into the rejuvenation processes of the evolving crust in the eastern NCC caused by structural, magmatic and metamorphic processes in an extensional setting. The fossil structural fabric of the convergent boundary in the eastern CAOB indicates that the back-arc action of the Paleo-Pacific Plate subduction did not reach the hinterland of Asia. PMID:26443323

  18. Surface rejuvenation for multilayer metal deposition on polymer microspheres via self-seeded electroless plating

    NASA Astrophysics Data System (ADS)

    Karagoz, Bunyamin; Sirkecioglu, Okan; Bicak, Niyazi

    2013-11-01

    A surface rejuvenation process was developed for generation variable thickness of metal deposits on polymer microspheres via electroless plating. Thus, Ni(II), Cu(II) and Ag(I) complexes formed on triethylenetetramine (TETA) functional crosslinked poly(glycidyl methacrylate) (PGMA) microspheres were reduced to zero-valent metals. The resulting metals (1.1-1.5 mmol g-1) were employed as seed points for electroless metal plating (self-seeding) without using Pd or tin pre-activating species. Treatment of the metalized surfaces with hydrazine or hydrazinium formate was demonstrated to reactivate (rejuvenate) the surface and allows further metal deposition from electroless plating solutions. Followed repeating of the surface rejuvenation-metalization steps resulted in step wise increasing of the metal deposits (90-290 mg per g in each cycle), as inferred from metal analyses, ESEM and XPS analysis. Experiments showed that, after 6 times of cycling the metal deposits exceed 1 g per g of the microspheres on average. The process seemed to be promising for tuning up of the metal thickness by stepwise electroless plating.

  19. PREFACE: 11th Asia-Pacific Conference on Plasma Science and Technology (APCPST-11) and 25th Symposium on Plasma Science for Materials (SPSM-25)

    NASA Astrophysics Data System (ADS)

    Watanabe, Takayuki; Kaneko, Toshio; Sekine, Makoto; Tanaka, Yasunori

    2013-06-01

    The 11th Asia-Pacific Conference on Plasma Science and Technology (APCPST-11) was held in Kyoto, Japan on 2-5 October 2012 with the 25th Symposium on Plasma Science for Materials (SPSM-25). SPSM has been held annually since 1988 under the sponsorship of The 153rd Committee on Plasma Materials Science, Japan Society for the Promotion of Science (JSPS). This symposium is one of the major activities of the Committee, which is organized by researchers in academia and industry for the purpose of advancing intersectional scientific information exchange and discussion of science and technology of plasma materials processing. APCPST and SPSM are jointly held biennially to survey the current status of low temperature and thermal plasma physics and chemistry for industrial applications. The whole area of plasma processing was covered from fundamentals to applications. Previous meetings were held in China, Japan, Korea, and Australia, attended by scientists from the Asia-Pacific and other countries. The joint conference was organized in plenary lectures, invited, contributed oral presentations and poster sessions. At this meeting, we had 386 participants from 10 countries and 398 presentations, including 26 invited presentations. This year, we arranged special topical sessions that covered green innovation, life innovation, and technical reports from industry. This conference seeks to bring the plasma community together and to create a forum for discussing the latest developments and issues, the challenges ahead in the field of plasma research and applications among engineers and scientists in Asia, the Pacific Rim, as well as Europe. This volume presents 44 papers that were selected via a strict peer-review process from full papers submitted for the proceedings of the conference. The topics range from the basic physics and chemistry of plasma processing to a broad variety of materials processing and environmental applications. This volume offers an overview of recent

  20. Effects of asphalt rejuvenator on thermal and mechanical properties on oxidized hot mixed asphalt pavements

    NASA Astrophysics Data System (ADS)

    Farace, Nicholas A.; Buttlar, William G.; Reis, Henrique

    2016-04-01

    The utilization of asphalt rejuvenator, and its effectiveness for restoring thermal and mechanical properties was investigated via Disk-shaped Compact Tension (DC(T)) and acoustic emission (AE) testing for determining mechanical properties and embrittlement temperatures of the mixtures. During the DC(T) testing the fracture energies and peak loads were used to measure the resistance of the rejuvenated asphalt to low temperature cracking. The AE testing monitored the acoustic emission activity while the specimens were cooled from room temperature to -40 °C to estimate the temperature at which thermal cracking began (i.e. the embrittlement temperature). First, a baseline response was obtained by obtaining the mechanical and thermal response of virgin HMA samples and HMA samples that had been exposed to oxidative aging for 36 hours at 135°C. The results showed the virgin samples had much higher peak loads and fracture energies than the 36 hours aged samples. Acoustic Emission showed similar results with the virgin samples having embrittlement temperatures 10 °C cooler than the 36 hours aged specimens. Then, overaged for 36 hours specimens were treated different amounts of rejuvenator (10%, 15%, and 20% by weight of binder content) and left to dwell for increased amount of time periods varying from one to eight weeks. It was observed that the AE results showed an improvement of embrittlement temperature with increasing with the dwell times. The 8 weeks specimens had cooler embrittlement temperatures than the virgin specimens. Finally, the low temperature effects on fracture energy and peak load of the rejuvenated asphalt was investigated. Rejuvenator was applied (10% by weight of binder) to specimens aged 36 hours at 135 °C, and the dwell time was varied from 1 to 4 weeks. The results showed that the peak loads were restored to levels of the virgin specimens, and the fracture energies improved to levels beyond that of the virgin specimens. The results also showed a

  1. Petrology and geochronology of lavas from Ka'ula Volcano: Implications for rejuvenated volcanism of the Hawaiian mantle plume

    NASA Astrophysics Data System (ADS)

    Garcia, Michael O.; Weis, Dominique; Jicha, Brian R.; Ito, Garrett; Hanano, Diane

    2016-07-01

    Marine surveying and submersible sampling of Ka'ula Volcano, located 100 km off the axis of the Hawaiian chain, revealed widespread areas of young volcanism. New 40Ar/39Ar and geochemical analyses of the olivine-phyric submarine and subaerial volcanic rocks show that Ka'ula is shrouded with 1.9-0.5 Ma alkalic basalts. The ages and chemistry of these rocks overlap with rejuvenated lavas on nearby, northern Hawaiian Island shields (Ni'ihau, Kaua'i and South Kaua'i Swell). Collectively, these rejuvenated lavas cover a vast area (∼7000 km2), much more extensive than any other area of rejuvenated volcanism worldwide. Ka'ula rejuvenated lavas range widely in alkalinity and incompatible element abundances (e.g., up to 10× P2O5 at a given MgO value) and ratios indicating variable degrees of melting of a heterogeneous source. Heavy REE elements in Ka'ula lavas are pinned at a mantle normalized Yb value of 10 ± 1, reflecting the presence of garnet in the source. Trace element ratios indicate the source also contained phlogopite and an Fe-Ti oxide. The new Ka'ula ages show that rejuvenated volcanism was nearly coeval from ∼0.3 to 0.6 Ma along a 450 km segment of the Hawaiian Islands (from West Maui to north of Ka'ula). The ages and volumes for rejuvenated volcanism are inconsistent with all but one geodynamic melting model proposed to date. This model advocates a significant contribution of pyroxenite to rejuvenated magmas. Analyses of olivine phenocryst compositions suggest a major (33-69%) pyroxenite component in Ka'ula rejuvenated lavas, which correlates positively with radiogenic Pb isotope ratios for Ka'ula. This correlation is also observed in lavas from nearby South Kaua'i lavas, as was reported for Atlantic oceanic islands. The presence of pyroxenite in the source may have extended the duration and volume of Hawaiian rejuvenated volcanism.

  2. ESO's First Observatory Celebrates 40th Anniversary

    NASA Astrophysics Data System (ADS)

    2009-03-01

    ESO's La Silla Observatory, which is celebrating its 40th anniversary, became the largest astronomical observatory of its time. It led Europe to the frontline of astronomical research, and is still one of the most scientifically productive in ground-based astronomy. ESO PR Photo 12a/09 La Silla Aerial View ESO PR Photo 12b/09 The ESO New Technology Telescope ESO PR Photo 12c/09 SEST on La Silla ESO PR Photo 12d/09 Looking for the best site ESO PR Video 12a/09 ESOcast 5 With about 300 refereed publications attributable to the work of the observatory per year, La Silla remains at the forefront of astronomy. It has led to an enormous number of scientific discoveries, including several "firsts". The HARPS spectrograph is the world's foremost exoplanet hunter. It detected the system around Gliese 581, which contains what may be the first known rocky planet in a habitable zone, outside the Solar System (ESO 22/07). Several telescopes at La Silla played a crucial role in discovering that the expansion of the Universe is accelerating (ESO 21/98) and in linking gamma-ray bursts -- the most energetic explosions in the Universe since the Big Bang - with the explosions of massive stars (ESO 15/98). Since 1987, the ESO La Silla Observatory has also played an important role in the study and follow-up of the nearest supernova, SN 1987A (ESO 08/07). "The La Silla Observatory continues to offer the astronomical community exceptional capabilities," says ESO Director General, Tim de Zeeuw. "It was ESO's first presence in Chile and as such, it triggered a very long and fruitful collaboration with this country and its scientific community." The La Silla Observatory is located at the edge of the Chilean Atacama Desert, one of the driest and loneliest areas of the world. Like other observatories in this geographical area, La Silla is located far from sources of polluting light and, as the Paranal Observatory that houses the Very Large Telescope, it has one of the darkest and clearest

  3. Intense pulsed light for skin rejuvenation, hair removal, and vascular lesions: a patient satisfaction study and review of the literature.

    PubMed

    Fodor, Lucian; Carmi, Nurit; Fodor, Adriana; Ramon, Ytzhack; Ullmann, Yehuda

    2009-04-01

    There are very few studies in the English literature that evaluate the patient satisfaction after treatment using intense pulsed light (IPL) and there is no reported study comparing the results of the three major IPL applications: rejuvenation, hair removal, and treatment of small vascular lesions. This study was designed to compare results after IPL treatment for skin rejuvenation, hair removal, and vascular lesions. Three groups of 30 consecutive patients having skin rejuvenation, hair removal, and small vascular lesions were selected and treated with the same IPL system. The evaluation was performed 1 year after the last treatment for the following parameters: age, sex, skin type, satisfaction, willingness to continue the treatment, willingness to recommend the treatment, and complications. Most of the minor complications occurred in the rejuvenation group (86.6%). No complications were recorded for 67% of patients having hair removal and for 75% having vascular lesion treatment. There was no significant difference in the level of satisfaction between the 3 groups (Kruskal Wallis test; P = 0.257). No difference regarding satisfaction was recorded in this study, but complications were more frequently encountered after rejuvenation. The findings of this study are useful when discussing IPL treatments with patients considering IPL procedures. PMID:19325333

  4. ‘Recharge My Exhausted Batteries’: Overbeck’s Rejuvenator, Patenting, and Public Medical Consumers, 1924–37

    PubMed Central

    Stark, James F.

    2014-01-01

    Although historians have shown that there has been a complex and multi-layered relationship between the body, medicine and the force of electricity, many avenues remain to be explored. One of the most prominent of these is the way in which electrotherapy technologies were marketed to a wide variety of different end users and intermediaries. This paper offers the first historical analysis of one such device – the Overbeck Rejuvenator – a 1920s electrotherapy machine designed for use by the general public. Its inventor, Otto Overbeck, was not a medical man and this enabled him to use aggressive strategies of newspaper advertising, using testimonials to market his product alongside appeals to his own scientific authority. He commissioned the prestigious Ediswan Company to manufacture the Rejuvenator on a large scale, and took out patents in eleven countries to persuade users of the efficacy of the device. In response to Overbeck’s activities, the British Medical Association enlisted an electrical engineer to examine the Rejuvenator, contacted practitioners whose endorsements were being used in publicity material, and denied Overbeck permission to advertise in the British Medical Journal. Despite this, the Rejuvenator brought its inventor wealth and notoriety, and helped redefine the concept of ‘rejuvenation’, even if the professional reception of such a device was almost universally hostile. This paper shows how the marketing, patenting and publishing of Overbeck combined to persuade members of the laity to try the Rejuvenator as an alternative form of therapy, bypassing the medical profession in the process. PMID:25284892

  5. NASA Administrator Dan Goldin speaks at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    NASA Administrator Daniel S. Goldin (right) addresses the audience at the Apollo 11 anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex, with seating under an unused Saturn V rocket like those that powered the Apollo launches . This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin 'Buzz' Aldrin who flew on Apollo 11, the launch of the first moon landing; Gene Cernan, who flew on Apollo 10 and 17 and was the last man to walk on the moon; and Walt Cunningham, who flew on Apollo 7.

  6. Gene Cernan speaks at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    During an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible, former Apollo astronaut Gene Cernan relates a humorous comment while Wally Schirra (background) gestures behind him. Cernan, who flew on Apollo 10 and 17, was the last man to walk on the moon; Schirra flew on Apollo 7. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin 'Buzz' Aldrin who flew on Apollo 11, the launch of the first moon landing, and Walt Cunningham, who also flew on Apollo 7.

  7. NASA Administrator Dan Goldin speaks at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    NASA Administrator Daniel S. Goldin addresses the audience at the Apollo 11 anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin 'Buzz' Aldrin who flew on Apollo 11, the launch of the first moon landing; Gene Cernan, who flew on Apollo 10 and 17 and was the last man to walk on the moon; and Walt Cunningham, who flew on Apollo 7.

  8. NASA-marks 5th anniversary of first lunar landing

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The accomplishments of the Apollo 11 Flight are presented as a tribute to the fifth anniversary of the first landing on the moon. The document contains: (1) a general description of the Apollo 11 Flight, (2) Presidential statements, (3) Apollo historical summary, (4) Apollo mission facts, (5) information on astronauts who are no longer in the program, and (6) transcripts of the landing sequence and first extravehicular activities on the moon.

  9. The First Reactor [40th Anniversary Commemorative Edition].

    DOE R&D Accomplishments Database

    1982-12-01

    This updated and revised story of the first reactor, or 'pile,' commemorates the 40th anniversary of the first controlled, self-sustaining nuclear chain reaction created by mankind. Enrico Fermi and his team of scientists initiated the reaction on December 2, 1941, underneath the West Stands of Stagg Field at the University of Chicago. Firsthand accounts of the participants as well as postwar recollections by Enrico and Laura Fermi are included.

  10. SeaWiFS Third Anniversary Global Biosphere

    NASA Technical Reports Server (NTRS)

    2002-01-01

    September 18,2000 is the third anniversary of the start of regular SeaWiFS operations of this remarkable planet called Earth. This SeaWiFS image is of the Global Biosphere depicting the ocean's long-term average phytoplankton chlorophyll concentration acquired between September 1997 and August 2000 combined with the SeaWiFS-derived Normalized Difference Vegetation Index (NDVI) over land during July 2000.

  11. Telstar Anniversary Reminds Us How Far Space Weather Has Come

    NASA Astrophysics Data System (ADS)

    Lanzerotti, Louis J.

    2012-08-01

    The 50th anniversary of the launch of the first active communications satellite, the Telstar satellite, was marked 10 July 2012. The successful operation of Telstar during its almost 6-month life registered several firsts, as emphasized by President John F. Kennedy in an announcement that also bore evidence of the central role played by the Cold War in U.S. foreign policy at the beginning of the space age.

  12. The first reactor [40th anniversary commemorative edition

    SciTech Connect

    1982-12-01

    This updated and revised story of the first reactor, or 'pile,' commemorates the 40th anniversary of the first controlled, self-sustaining nuclear chain reaction created by mankind. Enrico Fermi and his team of scientists initiated the reaction on December 2, 1941, underneath the West Stands of Stagg Field at the University of Chicago. Firsthand accounts of the participants as well as postwar recollections by Enrico and Laura Fermi are included.

  13. Topographic Evolution of Mountains: The Influence of Episodic Rejuvenation in Southern Spain.

    NASA Astrophysics Data System (ADS)

    Reinhardt, L. J.; Bishop, P.; Dempster, T. J.; Hoey, T. B.; Persano, C.; Barrows, T.; Fifield, K.; Sanderson, D.

    2003-12-01

    Uplift and denudation of the westernmost part of the Sierra Nevada, southern Spain has been assessed using a combination of optically stimulated luminescence (OSL) dating and 10Be and 26Al terrestrial cosmogenic nuclide (TCN) determinations, on both in-situ bedrock and detrital quartz from recent sediments, together with apatite fission track (AFT) ages from the metamorphic core. The Tertiary record of unroofing of this mountain area is shown to be episodic over all spatial and temporal scales. The presence of Tortonian marine sediments at altitudes up to 1830 m, indicate erosion rates < 0.03 mm.a -1 over the past 7 Ma. However, adjacent AFT determinations of 4 Ma record at least ca. 3.5 km of unroofing at similar elevations to those marine sediments. Current rejuvenation of a small (21 km2), high relief (2 km) catchment in the western Sierra Nevada has resulted in two distinct geomorphic zones: (1) a low angle, denudationally stable (unrejuvenated) headwater region with thin regolith cover and uniform erosion rates of 0.07 +/- 0.02 mm.a -1; and (2) a steep, actively rejuvenating lower catchment dominated by landsliding with erosion rates up to 7.9 +/- 0.4 mm.a -1. Rejuvenation of this catchment began ca. 17 ka following a rapid, tectonically generated ca. 50 m change in base level. An axial channel knickzone migrated upstream at ca. 0.5 m.a -1, successively rejuvenating tributaries and propagating up hillslopes at a mean rate of 0.05 m.a -1. The mean rate of river incision into schistose bedrock and fluvial terrace deposits dated by optically stimulated luminescence at ca. 13000 a is approximately 5 mm.a -1. The long lived contrast in geomorphic form, suggested by TCN and OSL measurement, has lead to the development of a general model for the medium-term denudation of small (< 50 km) rapidly uplifting catchments in which river incision, being slower than the uplift rate, is periodically subject to pulses of rejuvenation which lower base level. For example a ca. 50

  14. The apparent groundwater age rejuvenation caused by the human activity in Jakarta area, Indonesia

    NASA Astrophysics Data System (ADS)

    Kagabu, M.; Shimada, J.; Nakamura, T.; Delinom, R.; Taniguchi, M.

    2010-12-01

    The rapid urbanization in Jakarta area has become a serious subsurface environmental issues such as groundwater level decline and land subsidence due to excessive groundwater pumping. These problems began to emerge recently by some hydrological studies. The comparison of 14C activity between 1985 and 2008 shows the apparent groundwater age rejuvenation in the deep aquifer under the DKI Jakarta. We discussed by using a numerical groundwater flow model to evaluate the process of this rejuvenation in the urbanized area. Since the groundwater pumping was not performed intensely, the groundwater discharge flow toward the sea coast was dominant until 1983, however, this outward flux switched to intrusion flux into deeper aquifer after mid-1980s because of over-pumping in the urban area. The most largest flux among six flux directions toward the deep aquifer under the DKI Jakarta became “vertical downward flux” which means the shallower groundwater intrude into the deep one due to the excessive groundwater pumping from mid-1980s and this flux grows about 50% in 2000s. This result is consistent with the detection of chlorofluorocarbon (CFC)-12, which works as an indicator of young groundwater even in the deep groundwater. As the rejuvenation ratio “R” was determined by using 14C activity in the groundwater, R increase with the CFC-12 concentration and boths have good correlation. Besides, we estimated the “vertical downward flux” at each well's screen depth by the model estimation. The result shows that this flux has larger in the urban groundwater depression area and especially at shallower part of the deep aquifer, and it affects the magnitude of the shallow groundwater intrusion. Relationship between R and CFC-12 concentration. The diameter of cube shows the magnitude of the “vertical downward flux”

  15. Rejuvenating the Largest Treatment Wetland in Florida: Tracer Moment and Model Analysis of Wetland Hydraulic Performance

    NASA Astrophysics Data System (ADS)

    White, J. R.; Wang, H.; Jawitz, J. W.; Sees, M. D.

    2004-12-01

    The Orlando Easterly Wetland (OEW), the largest municipal treatment wetland in Florida, began operation in 1987 mainly for reducing nutrient loads in tertiary treated domestic wastewater produced by the city of Orlando. After more than ten years of operation, a decrease in total P removal effectiveness has occurred since 1999, even though the effluent concentration of the wetland has remained below the permitted limit of 0.2 mg/L,. Hydraulic inefficiency in the wetland, especially in the front-end cells of the north flow train, was identified as a primary cause of the reduced treatment effectiveness. In order to improve the hydraulic performance of the OEW and maintain its efficient phosphorus treatment, a rejuvenation program (including muck removal followed by re-vegetation) was initiated on the front-end cells of the north flow train in 2002. The effectiveness of this activity for the improvement of hydraulic performance was evaluated with a tracer test and subsequent moment and model analyses for the tracer resident time distribution (RTDs). Results were compared to similar tracer tests conducted prior to rejuvenation activities. The models included one-path tank-in-series (TIS), two-path TIS, one-dimensional transport with inflow and storage (OTIS), plug flow with dispersion (PFD), and plug flow with fractional dispersion (PFFD). The hydraulic performance was characterized by both wetland hydraulic efficiency and the spreading of tracers. The results demonstrated that the rejuvenation considerably improved the hydraulic performance in the restored area. Also presented is a comparison of the wetland response between both bromide and lithium tracers, and the determination of the complete moments of residence time distributions (RTD) in cell-network wetlands.

  16. The Tricky Tear Trough: A Review of Topical Cosmeceuticals for Periorbital Skin Rejuvenation.

    PubMed

    Pilkington, Stacey J; Belden, Sarah; Miller, Richard A

    2015-09-01

    There is a growing demand for noninvasive anti-aging products for which the periorbital region serves as a critical aspect of facial rejuvenation. This article reviews a multitude of cosmeceutical ingredients that have good scientific data, specifically for the periorbital region. Topical treatment options have exponentially grown from extensively studied retinoids, to recently developed technology, such as growth factors and peptides. With a focus on the periorbital anatomy, the authors review the mechanisms of action of topical cosmeceutical ingredients, effectiveness of ingredient penetration through the stratum corneum, and validity of clinical trials. PMID:26430490

  17. Spin correlated dielectric memory and rejuvenation in multiferroic CuCrS{sub 2}

    SciTech Connect

    Karmakar, A.; Dey, K.; Majumdar, S.; Giri, S.; Chatterjee, S.

    2014-02-03

    We report a rare consequence of memory effect in dielectric response (ϵ) and magnetic field induced rejuvenation in a relaxor-type multiferroic chalcogenide, CuCrS{sub 2}. Despite reasonably high conductivity, we are able to detect significant spontaneous polarization using an improvised technique verifying ferroelectric (FE) order. Concomitant appearance of both FE and antiferromagnetic orders authenticates multiferroicity. A smeared out FE transition and strong frequency dependence of the broadened peak in ϵ obeying Dynamical scaling law signify relaxor properties. We discuss the role of geometrical frustration in the antiferromagnetically coupled layered triangular lattice and metal ligand hybridization for these unusual properties.

  18. Ageing, rejuvenation and memory phenomena in a Bi-2212 superconductor showing the paramagnetic Meissner effect

    NASA Astrophysics Data System (ADS)

    Papadopoulou, E. L.; Nordblad, P.

    2001-07-01

    A melt-cast Bi 2 Sr 2 CaCu 2 O 8 sample showing the paramagnetic Meissner effect (PME) and an ageing phenomenon has been studied by magnetic relaxation and ac-susceptibility experiments. A memory behaviour is observed in the low frequency ac-suscpetibility and in the magnetisation vs. temperature curves measured on heating after certain cooling protocols. It is also found that large enough temperature shifts and positive temperature perturbations cause rejuvenation of the ageing system. All these observations show striking similarities with the ageing behaviour of spin glasses and indicate the existence of a low temperature glassy phase in this PME material.

  19. A preliminary process design and economic assessment of a catalyst rejuvenation process for waste disposal of refinery spent catalysts.

    PubMed

    Marafi, Meena; Stanislaus, Antony; Kam, Ezra

    2008-03-01

    Spent hydroprocessing catalysts from refineries have been classified as hazardous solid waste by the United States Environmental Protection Agency (USEPA), refiners must find a viable but economical solution to solve this serious environmental issue. Catalyst rejuvenation is an attractive option for minimizing the environmental problems associated with spent catalysts. In this study, a preliminary design for such a process and the corresponding economic analysis are performed to assess the proposed catalyst rejuvenation process for metal-fouled spent catalysts generated in residue hydroprocessing units. The scenarios used in the economic assessment are based on three options of process synthesis and two operator modes. It is found that the option of rejuvenating medium and lightly fouled spent catalyst produced by the refinery will be the best solution for refiners, both environmentally and economically. PMID:17316960

  20. Pathways for salvage and protection of the heart under stress: novel routes for cardiac rejuvenation.

    PubMed

    Cannatà, Antonio; Camparini, Luca; Sinagra, Gianfranco; Giacca, Mauro; Loffredo, Francesco S

    2016-07-15

    The world population is aging, and by 2017, there will be more people over the age of 65 than under age 5, and by 2050, two billion of the estimated nine billion people on Earth will be older than 60. Aging itself is a major cardiovascular risk factor, affecting morbidity and mortality of the aging population. At the same time, aging increases the likelihood of the presence of other risk factors. The aged myocardium is characterized by several structural and functional progressive changes that impair its ability to respond appropriately to stressful conditions. Although some progress to understand the complex mechanisms that underlie these phenotypic changes, the molecular pathways that determine the balance between aging and rejuvenation in the aged myocardium still remain elusive. In this article, we review molecular mechanisms responsible for the phenotypic changes observed with aging in the heart, providing insight into molecular pathways and pharmacological interventions that may rejuvenate the aged myocardium. A better understanding of these pathways is essential for determining their therapeutic potential in humans, improving the possibility that the increase in life expectancy that we are observing will be accompanied by a parallel increase in healthspan. PMID:27371745

  1. Midfacial rejuvenation by hyaluronic acid fillers and subcutaneous adipose tissue--a new concept.

    PubMed

    Wollina, Uwe

    2015-04-01

    In midface rejuvenation, hyaluronic acid (HA) fillers are commonly used as a versatile tool to improve appearance and to correct V-deformities and loss of volume. The induction of collagen as a major constituent of extracellular matrix (ECM) has been considered to be a basic effect of the rejuvenation procedure. Although commonly described as "dermal" soft fillers, histologic studies localized HA filler in the subcutaneous adipose tissue. Deep injection whenever possible lead to prolonged efficacy. Since volumizing HA filler induce mechanical stress not only to fibroblasts but adipocytes and deep injection itself causes minor trauma in the subcutaneous adipose tissue we suggest that the activation of adipose tissue-derived mesenchymal stem cells (ADMSC) is responsible for the observed clinical effects. We present a concept of filler action that discusses interactions of HA with adipocytes, ECM fiber network and ADMSC. Such a concept can explain the prolonged efficacy of deep midfacial filler placement and offers a new understanding to tailor HA fillers in the future. PMID:25665858

  2. Efficacy of mesotherapy in facial rejuvenation: a histological and immunohistochemical evaluation

    PubMed Central

    El-Domyati, Moetaz; El-Ammawi, Tarek S.; Moawad, Osama; El-Fakahany, Hasan; Medhat, Walid; Mahoney, Mỹ G.; Uitto, Jouni

    2012-01-01

    Background Mesotherapy, commonly known as “biorejuvenation” or “biorevitalization”, is a technique used to rejuvenate the skin by means of a transdermal injection of a multivitamin solution and natural plant extracts that are thought to improve the signs of skin aging. Objectives This prospective study aimed to evaluate the clinical effect of mesotherapy applied to periorbital wrinkles and to quantitatively evaluate histological changes in the skin occurring in response to the same treatment. Methods Six volunteers with Fitzpatrick skin types III or IV and Glogau class I–III wrinkles were subjected to a three-month course of mesotherapy injections in the periocular area (six sessions administered at two-week intervals). Standard photographs and skin biopsies were obtained from the treatment area at baseline, at the end of treatment, and at three months post-treatment. Quantitative evaluation of collagen types I, III, and VII, newly synthesized collagen, total elastin, and tropoelastin was performed using a computerized morphometric analysis. Results The clinical evaluation of volunteers at baseline, end of treatment, and three months post-treatment revealed no significant differences. Histological and immunostaining analysis of collagen types I, III, and VII, newly synthesized collagen, total elastin, and tropoelastin showed no statistically significant changes (P > 0.05) after mesotherapy injection. Conclusions The present study indicates that mesotherapy for skin rejuvenation does not result in statistically significant histological changes or clinical improvement. PMID:22788806

  3. Rejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment: A Pilot Study

    PubMed Central

    Chang, Anne Lynn S; Bitter, Patrick H; Qu, Kun; Lin, Meihong; Rapicavoli, Nicole A; Chang, Howard Y

    2013-01-01

    Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply 3′-end sequencing for expression quantification (“3-seq”) to discover the gene expression program associated with human photoaging and intrinsic skin aging (collectively termed “skin aging”), and the impact of broadband light (BBL) treatment. We find that skin aging was associated with a significantly altered expression level of 2,265 coding and noncoding RNAs, of which 1,293 became “rejuvenated” after BBL treatment; i.e., they became more similar to their expression level in youthful skin. Rejuvenated genes (RGs) included several known key regulators of organismal longevity and their proximal long noncoding RNAs. Skin aging is not associated with systematic changes in 3′-end mRNA processing. Hence, BBL treatment can restore gene expression pattern of photoaged and intrinsically aged human skin to resemble young skin. In addition, our data reveal, to our knowledge, a previously unreported set of targets that may lead to new insights into the human skin aging process. PMID:22931923

  4. In vivo multiphoton imaging of collagen remodeling after microablative fractional rejuvenation

    NASA Astrophysics Data System (ADS)

    Cicchi, Riccardo; Kapsokalyvas, Dimitrios; Troiano, Michela; Campolmi, Piero; Morini, Cristiano; Cosci, Alessandro; Massi, Daniela; Lotti, Torello; Pavone, Francesco S.

    2011-03-01

    The potential of multiphoton microscopy in providing in-vivo early diagnosis of skin lesions has already been demonstrated, while its capability in therapy follow-up has not been deeply explored so far. Two-photon excited fluorescence and second-harmonic generation microscopy were used in combination to follow-up collagen remodeling after laser micro-ablative rejuvenation. Treated regions of volunteers were imaged with multiphoton microscopy before and after treatment, and we found a strong age-dependence of the treatment effectiveness. In particular, the photorejuvenating effect was negligible in young subjects (< 30 years), whereas a significant production of new collagen was observed in aged subjects (> 70 years). Quantification of the amount of newly produced collagen and its organization were performed by means of visual examination of two-photon images. The obtained results demonstrate the performance of laser fractional micro-ablative rejuvenation without the need of an invasive biopsy as well as the wide applicability range of applications for multiphoton microscopy in clinical dermatology.

  5. EDITORIAL: STAM celebrates its 10th anniversary STAM celebrates its 10th anniversary

    NASA Astrophysics Data System (ADS)

    Ushioda, Sukekatsu

    2010-02-01

    I would like to extend my warmest greetings to the readers and staff of Science and Technology of Advanced Materials (STAM), on the occasion of its 10th anniversary. Launched in 2000, STAM marks this year an important milestone in its history. This is a great occasion to celebrate. STAM was founded by Tsuyoshi Masumoto in collaboration with Teruo Kishi and Toyonobu Yoshida as a world-class resource for the materials science community. It was initially supported by several materials research societies and was published as a regular peer-reviewed journal. Significant changes occurred in 2008, when the National Institute for Materials Science (NIMS) became solely responsible for all the costs of maintaining the journal. STAM was transformed into an open-access journal published by NIMS in partnership with IOP Publishing. As a result, the publication charges were waived and the entire STAM content, including all back issues, became freely accessible through the IOP Publishing website. The transition has made STAM more competitive and successful in global publication communities, with innovative ideas and approaches. The journal has also changed its publication strategy, aiming to publish a limited number of high-quality articles covering the frontiers of materials science. Special emphasis has been placed on reviews and focus issues, providing recent summaries of hot materials science topics. Publication has become electronic only; however, selected issues are printed and freely distributed at major international scientific events. The Editorial Board has been expanded to include leading experts from all over the world and, together with the Editorial Office, the board members are doing their best to transform STAM into a leading materials science journal. These efforts are paying off, as shown by the rapidly increasing number of article downloads and citations in 2009. I believe that the STAM audience can not only deepen their knowledge in their own specialties but

  6. 76 FR 33639 - Safety Zone; New York Water Taxi 10th Anniversary Fireworks

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; New York Water Taxi 10th Anniversary... to celebrate the 10th Anniversary of New York Water Taxi. The fireworks will commence at 9 p.m. on... CFR Part 165 Harbors, Marine safety, Navigation (water), Reporting and recordkeeping...

  7. 3 CFR 8401 - Proclamation 8401 of August 21, 2009. Fiftieth Anniversary of Hawaii Statehood

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false Proclamation 8401 of August 21, 2009. Fiftieth Anniversary of Hawaii Statehood 8401 Proclamation 8401 Presidential Documents Proclamations Proclamation 8401 of August 21, 2009 Proc. 8401 Fiftieth Anniversary of Hawaii StatehoodBy the President of the United States of America A Proclamation It is...

  8. 77 FR 37326 - Safety Zone; Grand Hotel 125th Anniversary Fireworks Celebration, Mackinaw Island, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    .... SUPPLEMENTARY INFORMATION: Table of Acronyms DHS Department of Homeland Security FR Federal Register NPRM Notice... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Grand Hotel 125th Anniversary Fireworks... launched from a point on Lake Huron to commemorate the Grand Hotel's 125th anniversary. The Captain of...

  9. "Anniversary Reaction": Important Events and Timing of Death in a Group of Roman Catholic Priests.

    ERIC Educational Resources Information Center

    Walker, Lee; Walker, Lawrence D.

    1990-01-01

    Compared death dates of 1,038 Roman Catholic priests with dates of Christmas, Easter, birthday, and day of ordination. Found no meaningful patterns of death around any anniversary, suggesting either no association between time of death and important anniversaries or that important event may be so extraordinary to each individuals that it is not…

  10. 3 CFR 8668 - Proclamation 8668 of May 3, 2011. 50th Anniversary of the Freedom Rides

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 3 The President 1 2012-01-01 2012-01-01 false Proclamation 8668 of May 3, 2011. 50th Anniversary of the Freedom Rides 8668 Proclamation 8668 Presidential Documents Proclamations Proclamation 8668 of May 3, 2011 Proc. 8668 50th Anniversary of the Freedom RidesBy the President of the United States of America A Proclamation Fifty years ago,...

  11. 3 CFR 8631 - Proclamation 8631 of February 28, 2011. 50th Anniversary of the Peace Corps

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 3 The President 1 2012-01-01 2012-01-01 false Proclamation 8631 of February 28, 2011. 50th Anniversary of the Peace Corps 8631 Proclamation 8631 Presidential Documents Proclamations Proclamation 8631 of February 28, 2011 Proc. 8631 50th Anniversary of the Peace CorpsBy the President of the United States of America A Proclamation In...

  12. 75 FR 29658 - Safety Zone; America's Discount Tire 50th Anniversary, Fireworks Display, South Lake Tahoe, CA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-27

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; America's Discount Tire 50th Anniversary... support of America's Discount Tire 50th Anniversary Fireworks Display. This safety zone is established to... Discount Tire will sponsor their 50th Anniversary Celebration Fireworks Display on July 11 and 13, 2010,...

  13. 78 FR 62293 - Safety Zone, Oyster Festival 30th Anniversary Fireworks Display, Oyster Bay; Oyster Bay, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-15

    ... several events associated with the Oyster Bay Oyster Festival. The Oyster Festival 30th Anniversary... CFR Part 165 RIN 1625-AA00 Safety Zone, Oyster Festival 30th Anniversary Fireworks Display, Oyster Bay... Festival 30th Anniversary fireworks display. This temporary safety zone is necessary to protect...

  14. 3 CFR 8829 - Proclamation 8829 of May 25, 2012. Commemoration of the 50th Anniversary of the Vietnam War

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the 50th Anniversary of the Vietnam War 8829 Proclamation 8829 Presidential Documents Proclamations Proclamation 8829 of May 25, 2012 Proc. 8829 Commemoration of the 50th Anniversary of the Vietnam WarBy the President of the United States of America A Proclamation As we observe the 50th anniversary of the...

  15. DETAILED INVESTIGATION OF THE REJUVENATION OF A SPENT ELECTROLESS NICKEL SOLUTION BY ELECTRODIALYSIS WITH A VIEW TO OPTIMIZING ELECTRODIALYSIS PERFORMANCE

    EPA Science Inventory

    The rejuvenation of spent electroless nickel baths by electrodialysis has received a considerable amount of attention over the past decade and the technique is being increasingly employed to extend electroless nickel bath life. However, thus far there has not been a detailed inve...

  16. Hand rejuvenation.

    PubMed

    Riyaz, Farhaad R; Ozog, David

    2015-09-01

    Aging of the hands results from both natural processes and chronic ultraviolet light exposure. Together, these cause textural and pigmentary changes, excess skin laxity, rhytides, and soft tissue atrophy that presents as prominent bones and tendons with easily visible veins. Many options are available for the reversal of these changes. Photoaging can be improved with chemical peels and light-based treatments (such as Q-switched lasers), resurfacing lasers, intense pulsed light, and photodynamic therapy. Soft tissue atrophy can be corrected with autologous fat, nonanimal stabilized hyaluronic acid, calcium hydroxylapatite, and poly-L lactic acid injections. The literature shows that these treatments have favorable outcomes for most patients; but in order to reduce known complications, it is important to understand the proper use and limitations of each modality. PMID:26566571

  17. Rejuvenating Teachers.

    ERIC Educational Resources Information Center

    Barter, Richard F.

    1984-01-01

    Reviews 6 topics of current reesearch on teacher effectiveness (school effectiveness, teacher shortage, teacher stress, classroom organization, professional growth, and job satisfaction) and suggests 13 activities for meeting faculty members' needs (including the establishment of faculty improvement and cultural funds, housing allowances, merit…

  18. Marking the 400th Anniversary of Kepler's Astronomia nova

    NASA Astrophysics Data System (ADS)

    Mahoney, T. J.

    2010-11-01

    Special Session 9 of the XXVII General Assembly (11-14 August 2009, Rio de Janeiro) was devoted to the topic “Marking the 400th Anniversary of Kepler's Astronomia nova”. During the two-and-a-half day meeting (spread over four days), there were nine invited and three contributed talks, a round-table discussion on the future of Kepler studies and an open session to propose the setting up of a Johannes Kepler Working Group under the aegis of the IAU.

  19. Age and petrology of alkalic postshield and rejuvenated-stage lava from Kauai, Hawaii

    USGS Publications Warehouse

    Clague, D.A.; Dalrymple, G.B.

    1988-01-01

    At the top of the Waimea Canyon Basalt on the island of Kauai, rare flows of alkalic postshield-stage hawaiite and mugearite overlie tholeiitic flows of the shield stage. These postshield-stage flows are 3.92 Ma and provide a younger limit for the age of the tholeiitic shield stage. The younger Koloa Volcanics consist of widespread alkalic rejuvenated-stage flows and vents of alkalic basalt, basanite, nephelinite, and nepheline melilitite that erupted between 3.65 and 0.52 Ma. All the flows older than 1.7 Ma occur in the west-northwestern half of the island and all the flows younger than 1.5 Ma occur in the east-southeastern half. The lithologies have no spatial or chronological pattern. The flows of the Koloa Volcanics are near-primary magmas generated by variable small degrees of partial melting of a compositionally heterogeneous garnet-bearing source that has about two-thirds the concentration of P2O5, rare-earth elements, and Sr of the source of the Honolulu Volcanics on the island of Oahu. The same lithology in the Koloa and Honolulu Volcanics is generated by similar degrees of partial melting of distinct source compositions. The lavas of the Koloa Volcanics can be generated by as little as 3 percent to as much as 17 percent partial melting for nepheline melilitite through alkalic basalt, respectively. Phases that remain in the residue of the Honolulu Volcanics, such as rutile and phlogopite, are exhausted during formation of the Koloa Volcanics at all but the smallest degrees of partial melting. The mantle source for Kauai lava becomes systematically more depleted in 87Sr/86Sr as the volcano evolves from the tholeiitic shield stage to the alkalic postshield stage to the alkalic rejuvenated stage: at the same time, the lavas become systematically more enriched in incompatible trace elements. On a shorter timescale, the lavas of the Koloa Volcanics display the same compositional trends, but at a lower rate of change. The source characteristics of the Koloa

  20. Journey Through the Universe: Tenth Anniversary in 2014!

    NASA Astrophysics Data System (ADS)

    Harvey, J.

    2014-07-01

    Hawaii will celebrate its tenth anniversary of the flagship Journey through the Universe program that began in 2004. The Gemini-led initiative has engaged hundreds of astronomers and astronomy educators that have visited over 2,700 classrooms, visiting over 60,000 students over the course of the last nine years. The scientists have brought excitement and inspiration about the life-long possibilities available in science, technology and mathematics to our students. The Journey program nurtures our students' innate curiosity, offers workshops for hundreds of teachers in Science, Technology, Engineering, and Math (STEM) education, and provides an opportunity for our community members to visit the classrooms alongside our astronomers. This ten-day annual event also includes Family Science Events that are enjoyed by thousands. For the 2013 program, our governor, Neil Abercrombie, inquired about the program and its enormous impact on Hawaii's students. Governor Abercrombie actively participated by visiting classrooms at different schools and attending our chamber of commerce appreciation event. This paper will share how the Journey program came to be and what is anticipated for the tenth anniversary. Journey through the Universe is a model outreach initiative that could be duplicated in other locations.

  1. Changes of the transverse diameter and volume and dosimetry before the 25th fraction during the course of intensity-modulated radiation therapy (IMRT) for patients with nasopharyngeal carcinoma

    SciTech Connect

    Yang Haihua; Hu Wei; Ding Weijun; Shan Guoping; Wang Wei; Yu Changhui; Wang Biyun; Shao Minghai; Wang Jianhua; Yang Weifang

    2012-07-01

    To quantify changes of the transverse diameter and volume and dosimetry, and to illustrate the inferiority of non-replanning during intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC) patients. Fifty-three NPC patients who received IMRT in 33 fractions were enrolled in this prospective trial. Before the 25th fraction, a new simulation computed tomography (CT) scan was acquired for all patients. The dose-volume histograms of the phantom plan were compared with the initial plan. Significant reduction of the transverse diameter of the nasopharyngeal, the neck, and 2 parotid glands volume was observed on second CT compared with the first CT (mean reduction 7.48 {+-} 4.45 mm, 6.80 {+-} 15.14 mm, 5.70 {+-} 6.26 mL, and 5.04 {+-} 5.85 mL, respectively; p < 0.01). The maximum dose and V-40 of the spinal cord, mean dose, and V30 of the left and right parotid, and V-50 of the brain stem were increased significantly in the phantom plan compared with the initial plan (mean increase 4.75 {+-} 5.55 Gy, 7.18 {+-} 10.07%, 4.51 {+-} 8.55 Gy, 6.59 {+-} 17.82%, 5.33 {+-} 8.55 Gy, 11.68 {+-} 17.11% and 1.48 {+-} 3.67%, respectively; p < 0.01). On the basis of dose constraint criterion in the RTOG0225 protocol, the dose of the normal critical structures for 52.83% (28/53) of the phantom plans were out of limit compared with 1.89% (1/53) of the initial plans (p < 0.0001). Because of the significant change in anatomy and dose before the 25th fraction during IMRT, replanning should be necessary during IMRT with NPC.

  2. ThermiVa: The Revolutionary Technology for Vulvovaginal Rejuvenation and Noninvasive Management of Female SUI.

    PubMed

    Magon, Navneet; Alinsod, Red

    2016-08-01

    Addressing vaginal laxity, atrophic vaginitis, stress urinary incontinence (SUI), and different manifestations of sexual dysfunction has always been problematic due to women's traditional difficulty discussing these issues with doctors as well as the societal attitude of resignation toward these conditions. The recent rise of non-invasive feminine rejuvenation using energy-based modalities to vaginal tissue has its origins in aesthetic medicine. Transcutaneous temperature-controlled radiofrequency therapy at the vulvovaginal region has shown promising results in giving a more youthful appearing vulva, restoration of vaginal elasticity and 'tightness', considerable improvement in SUI, reduction in overactive bladder symptoms, and reduction in sexual dysfunction. It is also emerging as the non-invasive treatment modality for mild to moderate SUI. It seems that the time has come, when women shall ever be grateful to their gynecologist for management of SUI with ThermiVa without an incision. PMID:27382227

  3. LATEST LASER AND LIGHT-BASED ADVANCES FOR ETHNIC SKIN REJUVENATION

    PubMed Central

    Elsaie, Mohamed Lotfy; Lloyd, Heather Woolery

    2008-01-01

    Background: Advances in nonablative skin rejuvenation technologies have sparked a renewed interest in the cosmetic treatment of aging skin. More options exist now than ever before to reverse cutaneous changes caused by long-term exposure to sunlight. Although Caucasian skin is more prone to ultraviolet light injury, ethnic skin (typically classified as types IV to VI) also exhibits characteristic photoaging changes. Widespread belief that inevitable or irreversible textural changes or dyspigmentation occurs following laser- or light-based treatments, has been challenged in recent years by new classes of devices capable of protecting the epidermis from injury during treatment. Objective: The purpose of this article is to review recent clinical advances in the treatment of photoaging changes in ethnic skin. This article provides a basis for the classification of current advances in nonablative management of ethnic skin. PMID:19881986

  4. Silent Synapses Speak Up: Updates of the Neural Rejuvenation Hypothesis of Drug Addiction

    PubMed Central

    Huang, Yanhua H.; Schlüter, Oliver M.; Dong, Yan

    2015-01-01

    A transient but prominent increase in the level of “silent synapses”—a signature of immature glutamatergic synapses that contain only NMDA receptors without stably expressed AMPA receptors—has been identified in the nucleus accumbens (NAc) following exposure to cocaine. As the NAc is a critical forebrain region implicated in forming addiction-associated behaviors, the initial discoveries have raised speculations about whether and how these drug-induced synapses mature and potentially contribute to addiction-related behaviors. Here, we summarize recent progress in recognizing the pathway-specific regulations of silent synapse maturation, and its diverse impacts on behavior. We provide an update of the guiding hypothesis—the “neural rejuvenation hypothesis”—with recently emerged evidence of silent synapses in cocaine craving and relapse. PMID:25829364

  5. Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies.

    PubMed

    Ingkaninan, Kornkanok; Temkitthawon, Prapapan; Chuenchom, Kanchanaporn; Yuyaem, Thitaree; Thongnoi, Warawit

    2003-12-01

    Acetylcholinesterase (AChE) inhibitor has been used as a drug for the symptomatic treatment of Alzheimer's disease. In order to search for new AChE inhibitors, 32 plants used in Thai traditional rejuvenating and neurotonic remedies were collected. The plant methanolic extracts were tested for AChE inhibitory activity using Ellman's colorimetric method in 96-welled microplates. The results showed that the methanolic extracts from roots of Stephania suberosa Forman. and Tabernaemontana divaricata (L.) R.Br. ex Roem. & Schult. at concentration of 0.1 mg/ml inhibited more than 90% of AChE activity. At the same concentration, four extracts, i.e. stems of Piper interruptum Opiz., seeds of Piper nigrum L., rootbarks of Butea superba Roxb. and roots of Cassia fistula L. extracts showed 50-65% inhibitory activity on AChE. The rest of the extracts showed the AChE inhibitory activity below 50%. PMID:14611889

  6. Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

    PubMed Central

    Marschallinger, Julia; Schäffner, Iris; Klein, Barbara; Gelfert, Renate; Rivera, Francisco J.; Illes, Sebastian; Grassner, Lukas; Janssen, Maximilian; Rotheneichner, Peter; Schmuckermair, Claudia; Coras, Roland; Boccazzi, Marta; Chishty, Mansoor; Lagler, Florian B.; Renic, Marija; Bauer, Hans-Christian; Singewald, Nicolas; Blümcke, Ingmar; Bogdahn, Ulrich; Couillard-Despres, Sebastien; Lie, D. Chichung; Abbracchio, Maria P.; Aigner, Ludwig

    2015-01-01

    As human life expectancy has improved rapidly in industrialized societies, age-related cognitive impairment presents an increasing challenge. Targeting histopathological processes that correlate with age-related cognitive declines, such as neuroinflammation, low levels of neurogenesis, disrupted blood–brain barrier and altered neuronal activity, might lead to structural and functional rejuvenation of the aged brain. Here we show that a 6-week treatment of young (4 months) and old (20 months) rats with montelukast, a marketed anti-asthmatic drug antagonizing leukotriene receptors, reduces neuroinflammation, elevates hippocampal neurogenesis and improves learning and memory in old animals. By using gene knockdown and knockout approaches, we demonstrate that the effect is mediated through inhibition of the GPR17 receptor. This work illustrates that inhibition of leukotriene receptor signalling might represent a safe and druggable target to restore cognitive functions in old individuals and paves the way for future clinical translation of leukotriene receptor inhibition for the treatment of dementias. PMID:26506265

  7. Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug.

    PubMed

    Marschallinger, Julia; Schäffner, Iris; Klein, Barbara; Gelfert, Renate; Rivera, Francisco J; Illes, Sebastian; Grassner, Lukas; Janssen, Maximilian; Rotheneichner, Peter; Schmuckermair, Claudia; Coras, Roland; Boccazzi, Marta; Chishty, Mansoor; Lagler, Florian B; Renic, Marija; Bauer, Hans-Christian; Singewald, Nicolas; Blümcke, Ingmar; Bogdahn, Ulrich; Couillard-Despres, Sebastien; Lie, D Chichung; Abbracchio, Maria P; Aigner, Ludwig

    2015-01-01

    As human life expectancy has improved rapidly in industrialized societies, age-related cognitive impairment presents an increasing challenge. Targeting histopathological processes that correlate with age-related cognitive declines, such as neuroinflammation, low levels of neurogenesis, disrupted blood-brain barrier and altered neuronal activity, might lead to structural and functional rejuvenation of the aged brain. Here we show that a 6-week treatment of young (4 months) and old (20 months) rats with montelukast, a marketed anti-asthmatic drug antagonizing leukotriene receptors, reduces neuroinflammation, elevates hippocampal neurogenesis and improves learning and memory in old animals. By using gene knockdown and knockout approaches, we demonstrate that the effect is mediated through inhibition of the GPR17 receptor. This work illustrates that inhibition of leukotriene receptor signalling might represent a safe and druggable target to restore cognitive functions in old individuals and paves the way for future clinical translation of leukotriene receptor inhibition for the treatment of dementias. PMID:26506265

  8. Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy

    SciTech Connect

    Zhu, Liang; Dong, Chuanming; Sun, Chenxi; Ma, Rongjie; Yang, Danjing; Zhu, Hongwen; Xu, Jun

    2015-08-21

    Aging of neural stem cell, which can affect brain homeostasis, may be caused by many cellular mechanisms. Autophagy dysfunction was found in aged and neurodegenerative brains. However, little is known about the relationship between autophagy and human neural stem cell (hNSC) aging. The present study used 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) to treat neural precursor cells (NPCs) derived from human embryonic stem cell (hESC) line H9 and investigate related molecular mechanisms involved in this process. MPTP-treated NPCs were found to undergo premature senescence [determined by increased senescence-associated-β-galactosidase (SA-β-gal) activity, elevated intracellular reactive oxygen species level, and decreased proliferation] and were associated with impaired autophagy. Additionally, the cellular senescence phenotypes were manifested at the molecular level by a significant increase in p21 and p53 expression, a decrease in SOD2 expression, and a decrease in expression of some key autophagy-related genes such as Atg5, Atg7, Atg12, and Beclin 1. Furthermore, we found that the senescence-like phenotype of MPTP-treated hNPCs was rejuvenated through treatment with a well-known autophagy enhancer rapamycin, which was blocked by suppression of essential autophagy gene Beclin 1. Taken together, these findings reveal the critical role of autophagy in the process of hNSC aging, and this process can be reversed by activating autophagy. - Highlights: • We successfully establish hESC-derived neural precursor cells. • MPTP treatment induced senescence-like state in hESC-derived NPCs. • MPTP treatment induced impaired autophagy of hESC-derived NPCs. • MPTP-induced hESC-derived NPC senescence was rejuvenated by activating autophagy.

  9. Rejuvenation of shallow-crustal silicic magma bodies at Augustine and Hayes volcanoes, Alaska

    NASA Astrophysics Data System (ADS)

    Coombs, M. L.; Vazquez, J. A.; Hayden, L. A.; Calvert, A. T.; Lidzbarski, M. I.; Andersen, N. L.; Till, C. B.

    2015-12-01

    Rejuvenation of crystal-rich magma bodies leading to eruption can occur on a variety of scales and in varied tectonic settings. Two examples from the Aleutian arc highlight 1) segregation of silicic melt from an intermediate mush, and 2) "defrosting" of a shallowly emplaced intrusion. Augustine Volcano erupted a late Pleistocene rhyolite pumice fall that we link through zircon geochronology to cumulate dioritic blocks, ripped from Augustine's shallow magmatic plumbing system and ejected during the 2006 eruption. Unpolished zircon rims from the rhyolite yield a U-Th age of ~25 ka, and interiors yield a dominant age population of ~26 ka. Zircons from diorites have interior ages and compositions indistinguishable from those of the rhyolite. The diorites, rhyolite, and early Holocene dacites define whole-rock linear unmixing trends consistent with melt (rhyolite) extraction from a mush (dacites), leaving behind a cumulate residue (diorites). A volatile-rich basalt erupted just prior to the rhyolite likely facilitated melt extraction from the mush. The rhyolitic Hayes River ignimbrite, erupted from Hayes volcano, contains dense porphyry blocks that match pumices in composition and phenocryst content and are samples of a shallow intrusion. Autocrystic monazite accommodated up to several weight % Th and significantly affected the U-Th ratio of the magma during differentiation. An isochron for early melt and low-U monazites yields an age of ~67 ka, whereas one for late melt and high-U monazites yields ~42 ka. This younger age is indistinguishable from the laser single crystal Ar-Ar age for sanidine of 41±2 ka (1 sigma). We interpret the apparent ~25 k.y. crystallization interval to represent the assembly and differentiation timescale associated with the Hayes magma body. Sharp reverse zoning in sanidine from pumice (but not porphyry) records a thermal pulse not seen in the more slowly reacting phases, suggesting that a rejuvenation event occurred just prior to eruption.

  10. The composition and distribution of the rejuvenated component across the Hawaiian plume: Hf-Nd-Sr-Pb isotope systematics of Kaula lavas and pyroxenite xenoliths

    NASA Astrophysics Data System (ADS)

    Bizimis, Michael; Salters, Vincent J. M.; Garcia, Michael O.; Norman, Marc D.

    2013-10-01

    Rejuvenated volcanism refers to the reemergence of volcanism after a hiatus of 0.5-2 Ma following the voluminous shield building stage of Hawaiian volcanoes. The composition of the rejuvenated source and its distribution relative to the center of the plume provide important constraints on the origin of rejuvenated volcanism. Near-contemporaneous lavas from the Kaula-Niihau-Kauai ridge and the North Arch volcanic field that are aligned approximately orthogonally to the plume track can constrain the lateral geochemical heterogeneity and distribution of the rejuvenated source across the volcanic chain. Nephelinites, phonolites and pyroxenite xenoliths from Kaula Island have radiogenic Hf, Nd and unradiogenic Sr isotope compositions consistent with a time-integrated depleted mantle source. The pyroxenites and nephelinites extend to the lowest 208Pb/204Pb reported in Hawaiian rocks. These data, along with new Pb isotope data from pyroxenites from the Salt Lake Crater (Oahu) redefine the composition of the depleted end-member of the Hawaiian rejuvenated source at 208Pb/204Pb=37.35±0.05, 206Pb/204Pb = 17.75±0.03, ɛNd = 9-10, ɛHf ˜16-17 and 87Sr/88Sr <0.70305. The revised isotope composition also suggests that this depleted component may contribute to LOA and KEA trend shield stage Hawaiian lavas, consistent with the rejuvenated source being part of the Hawaiian plume and not entrained upper mantle. The isotope systematics of rejuvenated magmas along the Kaula-Niihau-Kauai-North Arch transect are consistent with a larger proportion of the rejuvenated depleted component in the periphery of the plume track rather than along its axis.

  11. Silver Anniversary Conference: 25 Years of Higher Education Collective Bargaining. Proceedings of the Annual Conference of the National Center for the Study of Collective Bargaining in Higher Education and the Professions. School of Public Affairs, Baruch College, City University of New York (25th, New York, NY, April 1997).

    ERIC Educational Resources Information Center

    Johnson, Beth H., Ed.

    The 21 papers in this proceedings document are grouped into six sections which discuss the future of the U.S. labor movement; the future of tenure; faculty, unions, and management; technology and collective bargaining; fiscal problems in higher education; and legal issues in higher education. The papers are: (1) "Labor Relations for the 21st…

  12. Recognizing excellence in maternal and child health (MCH) epidemiology: the 2012 Co-hosted 18th MCH Epidemiology Conference and 22nd CityMatCH Urban MCH Leadership Conference, the 25th anniversary of the MCH Epidemiology Program, and the National MCH Epidemiology Awards.

    PubMed

    Kroelinger, Charlan D; Jones, Jessica; Barfield, Wanda D; Kogan, Michael D

    2014-09-01

    In December 2012, multiple leading agencies in the field of Maternal and Child Health (MCH) partnered to co-host a national MCH Epidemiology Conference. The Conference offered opportunities for peer exchange; presentation of new scientific methodologies, programs, and policies; dialogue on changes in the MCH field; and discussion of emerging MCH issues relevant to the work of MCH professionals. During the Conference, the MCH Epidemiology Program celebrated 25 years of success and partnership, and 16 MCH agencies presented six deserving health researchers and leaders with national awards in the areas of advancing knowledge, effective practice, outstanding leadership, excellence in teaching and mentoring, and young professional achievement. In September 2014, building on knowledge gained and changes in the field of MCH, leading agencies including the Centers for Disease Control and Prevention, the Health Resources and Services Administration, CityMatCH, and the Association of MCH Programs plan to replicate the achievements of 2012 through the implementation of a fully integrated national conference: the CityMatCH Leadership and MCH Epidemiology Conference. PMID:25091642

  13. The 25th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Twenty-two papers are documented regarding aeronautical and spacecraft hardware. Technological areas include actuators, latches, cryogenic mechanisms, vacuum tribology, bearings, robotics, ground support equipment for aerospace applications, and other mechanisms.

  14. Rejuvenation of Meiotic Cohesion in Oocytes during Prophase I Is Required for Chiasma Maintenance and Accurate Chromosome Segregation

    PubMed Central

    Weng, Katherine A.; Jeffreys, Charlotte A.; Bickel, Sharon E.

    2014-01-01

    Chromosome segregation errors in human oocytes are the leading cause of birth defects, and the risk of aneuploid pregnancy increases dramatically as women age. Accurate segregation demands that sister chromatid cohesion remain intact for decades in human oocytes, and gradual loss of the original cohesive linkages established in fetal oocytes is proposed to be a major cause of age-dependent segregation errors. Here we demonstrate that maintenance of meiotic cohesion in Drosophila oocytes during prophase I requires an active rejuvenation program, and provide mechanistic insight into the molecular events that underlie rejuvenation. Gal4/UAS inducible knockdown of the cohesion establishment factor Eco after meiotic S phase, but before oocyte maturation, causes premature loss of meiotic cohesion, resulting in destabilization of chiasmata and subsequent missegregation of recombinant homologs. Reduction of individual cohesin subunits or the cohesin loader Nipped B during prophase I leads to similar defects. These data indicate that loading of newly synthesized replacement cohesin rings by Nipped B and establishment of new cohesive linkages by the acetyltransferase Eco must occur during prophase I to maintain cohesion in oocytes. Moreover, we show that rejuvenation of meiotic cohesion does not depend on the programmed induction of meiotic double strand breaks that occurs during early prophase I, and is therefore mechanistically distinct from the DNA damage cohesion re-establishment pathway identified in G2 vegetative yeast cells. Our work provides the first evidence that new cohesive linkages are established in Drosophila oocytes after meiotic S phase, and that these are required for accurate chromosome segregation. If such a pathway also operates in human oocytes, meiotic cohesion defects may become pronounced in a woman's thirties, not because the original cohesive linkages finally give out, but because the rejuvenation program can no longer supply new cohesive linkages

  15. The Children's Inn at NIH Anniversary Key Messages | NIH MedlinePlus the Magazine

    MedlinePlus

    ... of this page please turn JavaScript on. Feature: The Children's Inn The Children's Inn at NIH Past Issues / Summer 2014 ... Contents Anniversary Key Messages Playground and Park at The Children's Inn at NIH. Photo courtesy of Mahan ...

  16. The role of the interaction between polar and subtropical jet in a case of depression rejuvenation over the Eastern Mediterranean

    NASA Astrophysics Data System (ADS)

    Prezerakos, N. G.; Flocas, H. A.; Brikas, D.

    2006-02-01

    In this paper, an attempt is made to investigate the synoptic-scale atmospheric conditions and dynamic processes leading to the rejuvenation of depressions or cyclogenesis over the Eastern Mediterranean during the cold period of the year. A case study analysis is carried out when the Polar Front Jet (PFJ) is positioned to the south of its normal seasonal position and interacts with the Subtropical Jet Stream (SJS), which is positioned to the north of its normal seasonal position. It was found that the vigorous rejuvenation of a northeastwards moving Atlas mountains depression on 15 March 1998 over Cyprus region is associated with an increase of the hydrodynamic instability due to the juxtaposition of a polar front jet streak to the subtropical jet stream. Furthermore, the rejuvenation is related to the combined effect of the direct and indirect cross vertical circulations appearing on the right side of the entrance of a polar jet streak and the left side of a subtropical jet streak exit, respectively.

  17. Efficacy of Microneedling Plus Human Stem Cell Conditioned Medium for Skin Rejuvenation: A Randomized, Controlled, Blinded Split-Face Study

    PubMed Central

    Lee, Hee Jung; Lee, Eo Gin; Kang, Sangjin; Sung, Jong-Hyuk; Chung, Hyung-Min

    2014-01-01

    Background The use of growth factors in skin rejuvenation is emerging as a novel anti-aging treatment. While the role of growth factors in wound healing is well established, their use in skin rejuvenation has only recently been to be studied and no controlled trials have been performed. Objective We evaluated the anti-aging effects of secretory factors of endothelial precursor cells differentiated from human embryonic stem cells (hESC-EPC) in Asian skin. Methods A total of 25 women were included in this randomized, controlled split-face study. The right and left sides of each participant's face were randomly allocated to hESC-EPC conditioned medium (CM) or saline. To enhance epidermal penetration, a 0.25-mm microneedle roller was used. Five treatment sessions were repeated at 2-week intervals. Results Physician's global assessment of pigmentation and wrinkles after treatment revealed statistically significant effects of microneedling plus hESC-EPC CM compared to microneedling alone (p<0.05). Skin measurements by Mexameter and Visiometer also revealed statistically significant effects of microneedling plus hESC-EPC CM on both pigmentation and wrinkles (p<0.05). The only minimal adverse event was mild desquamation in one participant. Conclusion Secretory factors of hESC-EPC improve the signs of skin aging and could be a potential option for skin rejuvenation. PMID:25324650

  18. A Geomorphological Analysis of the Cenozoic Rejuvenation of the Southwestern Norwegian 'Passive' Margin

    NASA Astrophysics Data System (ADS)

    McDermott, Jeni; Redfield, Tim; Terje Osmundsen, Per; Arnhold, Chad; Conrad, Dan

    2015-04-01

    Although the Norwegian and Greenland rifted margins underwent Early Paleocene breakup, the southwestern Norwegian continental margin exhibits 2 to 3 km-high, sharply asymmetric seaward-facing escarpments and a 250+ km long topographic displacement gradient, a morphology not consistent with simple margin evolution models that predict subsidence and cooling as the dominate processes in tectonically-quiescent regions. Such atypical margins present a paradox: How is high, rugged topography along rifted margins maintained for tens to hundreds of millions of years after the cessation of extension? Recent work indicates the offshore crustal thinning gradient, a measure of the length from the continental escarpment to the location of the maximum crustal thickness, may play a controlling role: where the gradient is sharp the topography is most elevated; where gentle, the escarpments are lower. Although controversy remains, it is generally accepted, based on offshore geophysical data and onshore geomorphology, thermochronology, and structural geology, that the southwestern Norwegian escarpment has undergone topographic rejuvenation during the Cenozoic. Although several mechanistic models invoking various contributions of active tectonism have been proposed, from remnant topography recently carved by extensive glaciation to active uplift along large-scale onshore margin-parallel faults, the rejuvenating mechanism has not been resolved. Non-glacial components of rock column uplift may possibly be occurring today: tectonic control of major drainage patterns has been proposed and recent work in the Møre-Trøndelag Fault Complex provides compelling evidence for discrete fault-bound tectonic blocks with unique exhumation histories. We are seeking to constrain the primary mode of Cenozoic deformation along the western Norwegian continental rifted margin by utilizing a tiered approach with distinct but complementary techniques encompassing tectonic geomorphology, structural geology

  19. Outer Circle Versus Inner Circle: Special Considerations While Rejuvenating an Indian Face Using Fillers

    PubMed Central

    Shetty, Rashmi

    2015-01-01

    Introduction: An oval face, pronounced cheek bones, a defined jaw line and a smooth Ogee curve are global aesthetic beauty goals. Though criteria are similar the Indian face poses some unique challenges because of the innate differences in skeletal shape, size, and soft tissue disposition. Width of the malar prominences and mandibular angles along with height are smaller compared to the other Asian and Caucasian populations along with a much heavier soft tissue disposition. This creates unique deficits and places unique demands on aesthetic intervention. Objectives: The evolution of practice patterns has lead to a variety of newer approaches; however, it is still common to target the nasolabial and mid-face volumizing as basic intervention for facial beautifying and rejuvenation. As aging progresses, Indian faces tend to get fuller and the tissue then descends downwards similar to other ethnic groups albeit more aggressive due to higher volumes of facial fat pad and smaller bone framework. Any excess correction in the inner circle zones will further add to the bulk along with cumulative remnants of previously administered fillers. Methods: In a younger face when the goal is beautification the attempt is to address the specific structural deficit on the outer bony framework along with the chin. This enhances the appearance immediately as well as holds up the tissue descent as they age. When the goal is youthful transition of an aging face, then again the bony changes further enhance the deficit in framework and the loss of fat pads along the periphery that is lateral forehead, temples and lateral cheek. Fat pad correction will give the most natural and best results as against working on the anterior mid cheek, nasolabials and angle of the mouth in a soft tissue heavy center zone of the face. Botulinum toxin and hyaluronic acid (HA) fillers remain the most popular facial injectables used for facial rejuvenation and structural enhancement. Results: Naturally enhanced

  20. Early Scientific Results and Future Prospects for the Rejuvenated Hubble Space Telescope

    NASA Technical Reports Server (NTRS)

    Niedner, Malcolm B.

    2010-01-01

    Following the extraordinarily successful Servicing Mission 4 (SM4) of Hubble Space Telescope (HST) in May of 2009, the Observatory is now fully equipped with a broad array of powerful science instruments that put it at the pinnacle of its scientific power. Relevant to the subject matter of the Beyond 2010 Conference, HST will be well-placed over the next five-plus years to advance our knowledge of the formation of high-redshift galaxies and their growth with cosmic time; the emergence of structure in the early universe via Dark Matter-driven gravitational instability; and the universe's expansion history and any resulting implications for the temporal character of Dark Energy. These are fitting projects for the iconic facility now celebrating its 20th anniversary in orbit.

  1. Localized rejuvenation of a crystal mush recorded in zircon temporal and compositional variation at the Lassen Volcanic Center, northern California

    USGS Publications Warehouse

    Klemetti, Erik W.; Clynne, Michael A.

    2014-01-01

    Zircon ages and trace element compositions from recent silicic eruptions in the Lassen Volcanic Center (LVC) allow for an evaluation of the timing and conditions of rejuvenation (reheating and mobilization of crystals) within the LVC magmatic system. The LVC is the southernmost active Cascade volcano and, prior to the 1980 eruption of Mount St. Helens, was the site of the only eruption in the Cascade arc during the last century. The three most recent silicic eruptions from the LVC were very small to moderate-sized lava flows and domes of dacite (1915 and 27 ka eruptions of Lassen Peak) and rhyodacite (1.1 ka eruption of Chaos Crags). These eruptions produced mixed and mingled lavas that contain a diverse crystal cargo, including zircon. 238U-230Th model ages from interior and surface analyses of zircon reveal ages from ~17 ka to secular equilibrium (>350 ka), with most zircon crystallizing during a period between ~60–200 ka. These data support a model for localized rejuvenation of crystal mush beneath the LVC. This crystal mush evidently is the remnant of magmatism that ended ~190 ka. Most zircon are thought to have been captured from “cold storage” in the crystal mush (670–725°C, Hf >10,000 ppm, Eu/Eu* 0.25–0.4) locally remobilized by intrusion of mafic magma. A smaller population of zircon (>730°C, Hf <10,000 ppm, Eu/Eu* >0.4) grew in, and are captured from, rejuvenation zones. These data suggest the dominant method to produce eruptible melt within the LVC is small-scale, local rejuvenation of the crystal mush accompanied by magma mixing and mingling. Based on zircon stability, the time required to heat, erupt and then cool to background conditions is relatively short, lasting a maximum of 10 s–1000 s years. Rejuvenation events in the LVC are ephemeral and permit eruption within an otherwise waning and cooling magmatic body.

  2. Localized rejuvenation of a crystal mush recorded in zircon temporal and compositional variation at the Lassen Volcanic Center, northern California.

    PubMed

    Klemetti, Erik W; Clynne, Michael A

    2014-01-01

    Zircon ages and trace element compositions from recent silicic eruptions in the Lassen Volcanic Center (LVC) allow for an evaluation of the timing and conditions of rejuvenation (reheating and mobilization of crystals) within the LVC magmatic system. The LVC is the southernmost active Cascade volcano and, prior to the 1980 eruption of Mount St. Helens, was the site of the only eruption in the Cascade arc during the last century. The three most recent silicic eruptions from the LVC were very small to moderate-sized lava flows and domes of dacite (1915 and 27 ka eruptions of Lassen Peak) and rhyodacite (1.1 ka eruption of Chaos Crags). These eruptions produced mixed and mingled lavas that contain a diverse crystal cargo, including zircon. 238U-230Th model ages from interior and surface analyses of zircon reveal ages from ∼17 ka to secular equilibrium (>350 ka), with most zircon crystallizing during a period between ∼60-200 ka. These data support a model for localized rejuvenation of crystal mush beneath the LVC. This crystal mush evidently is the remnant of magmatism that ended ∼190 ka. Most zircon are thought to have been captured from "cold storage" in the crystal mush (670-725°C, Hf >10,000 ppm, Eu/Eu* 0.25-0.4) locally remobilized by intrusion of mafic magma. A smaller population of zircon (>730°C, Hf <10,000 ppm, Eu/Eu* >0.4) grew in, and are captured from, rejuvenation zones. These data suggest the dominant method to produce eruptible melt within the LVC is small-scale, local rejuvenation of the crystal mush accompanied by magma mixing and mingling. Based on zircon stability, the time required to heat, erupt and then cool to background conditions is relatively short, lasting a maximum of 10 s-1000 s years. Rejuvenation events in the LVC are ephemeral and permit eruption within an otherwise waning and cooling magmatic body. PMID:25470726

  3. Localized Rejuvenation of a Crystal Mush Recorded in Zircon Temporal and Compositional Variation at the Lassen Volcanic Center, Northern California

    PubMed Central

    Klemetti, Erik W.; Clynne, Michael A.

    2014-01-01

    Zircon ages and trace element compositions from recent silicic eruptions in the Lassen Volcanic Center (LVC) allow for an evaluation of the timing and conditions of rejuvenation (reheating and mobilization of crystals) within the LVC magmatic system. The LVC is the southernmost active Cascade volcano and, prior to the 1980 eruption of Mount St. Helens, was the site of the only eruption in the Cascade arc during the last century. The three most recent silicic eruptions from the LVC were very small to moderate-sized lava flows and domes of dacite (1915 and 27 ka eruptions of Lassen Peak) and rhyodacite (1.1 ka eruption of Chaos Crags). These eruptions produced mixed and mingled lavas that contain a diverse crystal cargo, including zircon. 238U-230Th model ages from interior and surface analyses of zircon reveal ages from ∼17 ka to secular equilibrium (>350 ka), with most zircon crystallizing during a period between ∼60–200 ka. These data support a model for localized rejuvenation of crystal mush beneath the LVC. This crystal mush evidently is the remnant of magmatism that ended ∼190 ka. Most zircon are thought to have been captured from “cold storage” in the crystal mush (670–725°C, Hf >10,000 ppm, Eu/Eu* 0.25–0.4) locally remobilized by intrusion of mafic magma. A smaller population of zircon (>730°C, Hf <10,000 ppm, Eu/Eu* >0.4) grew in, and are captured from, rejuvenation zones. These data suggest the dominant method to produce eruptible melt within the LVC is small-scale, local rejuvenation of the crystal mush accompanied by magma mixing and mingling. Based on zircon stability, the time required to heat, erupt and then cool to background conditions is relatively short, lasting a maximum of 10 s–1000 s years. Rejuvenation events in the LVC are ephemeral and permit eruption within an otherwise waning and cooling magmatic body. PMID:25470726

  4. In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes.

    PubMed

    García-Matas, Silvia; Paul, Rajib K; Molina-Martínez, Patricia; Palacios, Hector; Gutierrez, Vincent M; Corpas, Rubén; Pallas, Mercè; Cristòfol, Rosa; de Cabo, Rafael; Sanfeliu, Coral

    2015-06-01

    Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with the effects of caloric restriction, the most effective rejuvenating treatment known so far. Analysis of the transcriptomic profiles of SAMP8 astrocytes cultured in control conditions and treated with caloric restriction serum was performed using mRNA microarrays. A decrease in mitochondrial and ribosome mRNA, which was restored by caloric restriction, confirmed the age-related profile of SAMP8 astrocytes and the benefits of caloric restriction. An amelioration of antioxidant and neurodegeneration-related pathways confirmed the brain benefits of caloric restriction. Studies of oxidative stress and mitochondrial function demonstrated a reduction of oxidative damage and partial improvement of mitochondria after caloric restriction. In summary, caloric restriction showed a significant tendency to normalize pathologically aged astrocytes through the activation of pathways that are protective against the age-related deterioration of brain physiology. PMID:25711920

  5. A hybrid Brownian Dynamics model for yielding, aging, and rejuvenation in deforming polymeric glasses

    NASA Astrophysics Data System (ADS)

    Zou, Weizhong; Larson, Ronald

    2015-03-01

    We describe the rheology of polymeric glasses by combining a simple constitutive equation for the fast segmental modes, borrowed from Fielding, et al., with Brownian dynamics (BD) simulations of the slow polymer modes. The BD simulations determine the polymeric stress from ensembles of finitely extensible bead-spring chains, where the bead drag coefficient is governed by solutions to the equation for segmental relaxation. Thus the model treats the short glassy segmental mode as ``solvent'' for the polymer modes. With rubbery modulus for the slow-relaxing polymer modes as one of our model parameters, stress-dependent relaxation, physical aging, flow rejuvenation as well as strain-hardening and recovery can be successfully accounted for in uniaxial extension and steady shear, without the use of an artificial ``crinkle factor'' used to account for recoil dynamics in previous work. Our simulation results remarkably agree with the experimental data from Lee et al. A comparison between our model and the barrier-hopping theory is also made. The authors acknowledge discussions with M. E. Cates and S. M. Fielding.

  6. [The <rejuvenation> and beginnings of Chilean endocrinology in the 1920s].

    PubMed

    Sánchez Delgado, Marcelo

    2016-01-01

    Rejuvenation was a chapter of critical importance for the worldwide development of endocrinology in the 1920s. This work explores the acceptance of these techniques in Chile. Starting in the late 19th century, the Chilean Medical Journal (Revista Médica de Chile) incorporated references to experiments with endocrine gland preparations that were being conducted in Europe at the time. An appropriation of the experiments by the Austrian Eugen Steinach began in 1920, with prominent figures such as the Italian professor Juan Noe Crevani and the young Chilean student Ottmar Wilhelm. Between 1922 and 1924, Wilhelm developed a series of experiments on dogs, bulls, pigs, rats and Welfare Board patients through the so-called Steinach operation, which consisted of the sectioning of the efferent channel in one of the testicles. Professor Noe's scientific patronage policy and Wilhelm's strategy of succession in the field led the latter to hold a chair in the new School of Medicine of Universidad de Concepci6n at the age of 25. From this position, the. figure of Wilhelm was fundamental for the development of a line of endocrinological research that was able to position Universidad de Concepci6n as a scientific development centre, which was strengthened by the arrival of another disciple of Steinach in Chile, the Latvian professor Alejandro Lipschütz. PMID:27363250

  7. In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes

    PubMed Central

    García-Matas, Silvia; Paul, Rajib K; Molina-Martínez, Patricia; Palacios, Hector; Gutierrez, Vincent M; Corpas, Rubén; Pallas, Mercè; Cristòfol, Rosa; de Cabo, Rafael; Sanfeliu, Coral

    2015-01-01

    Astrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with the effects of caloric restriction, the most effective rejuvenating treatment known so far. Analysis of the transcriptomic profiles of SAMP8 astrocytes cultured in control conditions and treated with caloric restriction serum was performed using mRNA microarrays. A decrease in mitochondrial and ribosome mRNA, which was restored by caloric restriction, confirmed the age-related profile of SAMP8 astrocytes and the benefits of caloric restriction. An amelioration of antioxidant and neurodegeneration-related pathways confirmed the brain benefits of caloric restriction. Studies of oxidative stress and mitochondrial function demonstrated a reduction of oxidative damage and partial improvement of mitochondria after caloric restriction. In summary, caloric restriction showed a significant tendency to normalize pathologically aged astrocytes through the activation of pathways that are protective against the age-related deterioration of brain physiology. PMID:25711920

  8. The Comparative Toxicogenomics Database's 10th year anniversary: update 2015

    PubMed Central

    Davis, Allan Peter; Grondin, Cynthia J.; Lennon-Hopkins, Kelley; Saraceni-Richards, Cynthia; Sciaky, Daniela; King, Benjamin L.; Wiegers, Thomas C.; Mattingly, Carolyn J.

    2015-01-01

    Ten years ago, the Comparative Toxicogenomics Database (CTD; http://ctdbase.org/) was developed out of a need to formalize, harmonize and centralize the information on numerous genes and proteins responding to environmental toxic agents across diverse species. CTD's initial approach was to facilitate comparisons of nucleotide and protein sequences of toxicologically significant genes by curating these sequences and electronically annotating them with chemical terms from their associated references. Since then, however, CTD has vastly expanded its scope to robustly represent a triad of chemical–gene, chemical–disease and gene–disease interactions that are manually curated from the scientific literature by professional biocurators using controlled vocabularies, ontologies and structured notation. Today, CTD includes 24 million toxicogenomic connections relating chemicals/drugs, genes/proteins, diseases, taxa, phenotypes, Gene Ontology annotations, pathways and interaction modules. In this 10th year anniversary update, we outline the evolution of CTD, including our increased data content, new ‘Pathway View’ visualization tool, enhanced curation practices, pilot chemical–phenotype results and impending exposure data set. The prototype database originally described in our first report has transformed into a sophisticated resource used actively today to help scientists develop and test hypotheses about the etiologies of environmentally influenced diseases. PMID:25326323

  9. The Comparative Toxicogenomics Database's 10th year anniversary: update 2015.

    PubMed

    Davis, Allan Peter; Grondin, Cynthia J; Lennon-Hopkins, Kelley; Saraceni-Richards, Cynthia; Sciaky, Daniela; King, Benjamin L; Wiegers, Thomas C; Mattingly, Carolyn J

    2015-01-01

    Ten years ago, the Comparative Toxicogenomics Database (CTD; http://ctdbase.org/) was developed out of a need to formalize, harmonize and centralize the information on numerous genes and proteins responding to environmental toxic agents across diverse species. CTD's initial approach was to facilitate comparisons of nucleotide and protein sequences of toxicologically significant genes by curating these sequences and electronically annotating them with chemical terms from their associated references. Since then, however, CTD has vastly expanded its scope to robustly represent a triad of chemical-gene, chemical-disease and gene-disease interactions that are manually curated from the scientific literature by professional biocurators using controlled vocabularies, ontologies and structured notation. Today, CTD includes 24 million toxicogenomic connections relating chemicals/drugs, genes/proteins, diseases, taxa, phenotypes, Gene Ontology annotations, pathways and interaction modules. In this 10th year anniversary update, we outline the evolution of CTD, including our increased data content, new 'Pathway View' visualization tool, enhanced curation practices, pilot chemical-phenotype results and impending exposure data set. The prototype database originally described in our first report has transformed into a sophisticated resource used actively today to help scientists develop and test hypotheses about the etiologies of environmentally influenced diseases. PMID:25326323

  10. Report on the 5‘th scientific meeting of the “Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie” (NEUROWIND e.V.) held in Motzen, Germany, Oct. 25th – Oct. 27th, 2013

    PubMed Central

    2013-01-01

    From october 25th - 27th 2013, the 5th NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. This year more than 60 doctoral students and postdocs from over 25 different groups working in German university hospitals or research institutes attended the meeting to discuss their latest findings in the fields of neuroimmunology, neurodegeneration and neurovascular research. All participants appreciated the stimulating environment in Motzen, Brandenburg, and people took the opportunity for scientific exchange, discussion about ongoing projects and already started further collaborations. Like in the previous years, the symposium was regarded as a very well organized platform to support research of young investigators in Germany. According to the major aim of NEUROWIND e.V. to support younger researchers in Germany the 3rd NEUROWIND YOUNG SCIENTIST AWARD for experimental neurology was awarded to Ruth Stassart working in the group of Klaus Armin Nave and Wolfgang Brück (MPI Göttingen and Department of Neuropathology, Göttingen Germany). The successful work was published in Nature Neuroscience entitled “A role for Swann cell-derived neuregulin-1 in remyelination”. This outstanding paper deals with the function of Schwann cell neuregulin as an endogenous factor for myelin repair. The award is endowed with 20.000 Euro sponsored by Merck Serono GmbH, Darmstadt, Germany (unrestricted educational grant). This year’s keynote lecture was given by Albert Ludolph, Head of the Department of Neurology at the University Clinic of Ulm. Dr. Ludolph highlighted the particular role of individual scientists for the development of research concepts in Alzheimer´s disease (AD) and frontotemporal dementia (FTD). PMID:24330587

  11. Multiple minimally invasive Erbium:YAG laser mini-peels for skin rejuvenation: An objective assessment

    PubMed Central

    El-Domyati, Moetaz; El-Ammawi, Tarek S.; Medhat, Walid; Moawad, Osama; Mahoney, Mỹ G.; Uitto, Jouni

    2012-01-01

    Summary Background As the demand for minimally invasive rejuvenation is increasing, micro-peel resurfacing using Erbium:Yttrium Aluminium Garnet (Er:YAG ) laser 2940 nm has been reported for the treatment of photoaged skin without ablation of the epidermis. However, little is known about the efficacy and underlying histologic changes associated with this type of treatment. Aims The purpose of this study is to evaluate the clinical effect and objectively quantify the histological changes in response to multiple sessions of Er:YAG laser 2940 nm mini-peels. Patients and methods Six female volunteers of Fitzpatrick skin type III-IV and Glogau’s class I-III wrinkles were subjected to six microresurfacing peels at 2-week intervals using Er:YAG 2940 nm laser at sub-ablative fluences of 2 - 3 J/cm2 to treat periorbital rhytides. Quantitative evaluation of collagen types I, III and VII, newly synthesized collagen, total elastin and tropoelastin was performed by histochemistry and immunohistochemistry coupled with computerized morphometric analysis at base line, end of treatment, and three months post treatment. Results Compared to the base line, evaluation of volunteers revealed obvious clinical improvement in response to Er:YAG mini-peels. Collagen types I, III, and VII, as well as newly synthesized collagen, together with tropoelastin showed a statistically significant increase in response to treatment, while the mean level of total elastin was significantly decreased in response to treatment. However, this was followed by regression of improvement at 3 months post treatment, but was still better than baseline. Conclusions The present study revealed that multiple Er:YAG mini-peels is a promising treatment option for photoaging as it reverses the signs of photoaged skin with little downtime and side effects. However, to maintain the short term improvement achieved after treatment, continued Er:YAG 2940 nm laser mini-peels is required. PMID:22672276

  12. Unusual δ56Fe values in Samoan rejuvenated lavas generated in the mantle

    NASA Astrophysics Data System (ADS)

    Konter, Jasper G.; Pietruszka, Aaron J.; Hanan, Barry B.; Finlayson, Valerie A.; Craddock, Paul R.; Jackson, Matthew G.; Dauphas, Nicolas

    2016-09-01

    Several magmatic processes contribute to the Fe isotope composition of igneous rocks. Most basalts fall within a limited range of δ56Fe (+ 0.10 ± 0.05 ‰), although more differentiated lavas trend towards slightly elevated values (up to + 0.3 ‰). New data for basalts and olivine crystals from the Samoan Islands show higher δ56Fe values than have previously been reported for basalts worldwide. Common magmatic processes - from partial melting of average mantle to subsequent differentiation of melts - cannot sufficiently fractionate the Fe isotopes to explain the elevated δ56Fe values (∼ + 0.3 ‰) in rejuvenated Samoan lavas. Instead, a mantle source with an elevated δ56Fe value - in conjunction with effects due to common magmatic processes - is required. The Samoan mantle source is known to be unique in its radiogenic isotope composition and indications that melting of the Samoan mantle source can generate elevated δ56Fe values in lavas comes from: (1) High fO2 values of Samoan lavas and their likely sources affecting Fe isotope fractionation during melting; (2) Metasomatism that caused elevated δ56Fe in the Samoan mantle, as observed in xenoliths; and (3) Involvement of a pyroxenite source lithology, based on the Zn/Fe ratios and TiO2 (and other high field-strength element) abundances of the lavas, that can generate melts with elevated δ56Fe values. Two models are presented to explain the elevated δ56Fe values in Samoan lavas: a metasomatized source (∼ + 0.07 ‰) or the presence of a pyroxenite source component (∼ + 0.12 ‰). Both models subsequently elevate δ56Fe values with both partial melting (∼ + 0.14 ‰) and fractional crystallization (∼ + 0.1 ‰). These processes may be related to an upwelling mantle plume with a pyroxenite component, or melting of previously metasomatized upper mantle.

  13. Stem Cells Rejuvenate Radiation-Impaired Vasculogenesis in Murine Distraction Osteogenesis

    PubMed Central

    Deshpande, Sagar S.; Gallagher, Kathleen K.; Donneys, Alexis; Nelson, Noah S.; Guys, Nicholas P.; Felice, Peter A.; Page, Erin E.; Sun, Hongli; Krebsbach, Paul H.; Buchman, Steven R.

    2015-01-01

    Background Radiotherapy is known to be detrimental to bone and soft-tissue repair. Bone marrow stromal cells have been shown to enhance bone regeneration during distraction osteogenesis following radiation therapy. The authors posit that transplanted bone marrow stromal cells will significantly augment the mandibular vascularity devastated by radiation therapy. Methods Nineteen male Lewis rats were split randomly into three groups: distraction osteogenesis only (n = 5), radiation therapy plus distraction osteogenesis (n = 7), and radiation therapy plus distraction osteogenesis with intraoperative placement of 2 million bone marrow stromal cells (n = 7). A mandibular osteotomy was performed, and an external fixator device was installed. From postoperative days 4 through 12, rats underwent a gradual 5.1-mm distraction followed by a 28-day consolidation period. On postoperative day 40, Microfil was perfused into the vasculature and imaging commenced. Vascular radiomorphometric values were calculated for regions of interest. An analysis of variance with post hoc Tukey or Games-Howell tests was used, dependent on data homogeneity. Results Stereologic analysis indicated significant remediation in vasculature in the bone marrow stromal cell group compared with the radiation therapy/distraction osteogenesis group. Each of five metrics idicated significant improvements from radiation therapy/distraction osteogenesis to the bone marrow stromal cell group, with no difference between the bone marrow stromal cell group and the distraction osteogenesis group. Conclusions Bone marrow stromal cells used together with distraction osteogenesis can rejuvenate radiation-impaired vasculogenesis in the mandible, reversing radiation therapy–induced isotropy and creating a robust vascular network. Bone marrow stromal cells may offer clinicians an alternative reconstructive modality that could improve the lifestyle of patients with hypovascular bone. PMID:25415276

  14. The development of hyperbaric oxygen therapy for skin rejuvenation and treatment of photoaging.

    PubMed

    Asadamongkol, Bralipisut; Zhang, John H

    2014-01-01

    Hyperbaric oxygen therapy (HBOT), a therapy that have patients breath in pure oxygen in a pressurized chamber, has been long used as a treatment for conditions such as decompression sickness and carbon monoxide poisoning. Oxygen recently has been found to be an important component in skin rejuvenation, treatment of photoaging skin, and improvement in skin complexions. The interest in the use of HBOT for this purpose is continually growing and becoming more widespread. In addition to aging and genetic makeup, chronic UV radiation due to everyday exposure, especially UV-B, can greatly increase the rate of wrinkle formation through increasing skin angiogenesis and degradation of extracellular matrix molecules. The use of HBOT and hyperoxia conditions has been found to attenuate the formation of wrinkles from UV irradiation. It accomplishes the task by possibly inhibiting various processes and pathways involved such as the HIF1-α, VEGF, neutrophil infiltrations, and MMP-2 & MMP-9, which are directly involved with promoting skin angiogenesis in its active state. There are currently medical aesthetic clinics that are using oxygen therapy under high pressure applied directly to skin to reduce visible wrinkles but this procedure is not widespread yet due to more research that needs to be done on this topic. However, this treatment for wrinkles is definitely growing due to recent studies done showing the effectiveness of oxygen therapy on wrinkles. This review article will explore and summarize researches done on possible mechanisms dealing with the use of oxygen therapy for reduction of UVB-caused wrinkles, its side effects, and its possible future improvement and use in medicine. PMID:24690202

  15. The development of hyperbaric oxygen therapy for skin rejuvenation and treatment of photoaging

    PubMed Central

    2014-01-01

    Hyperbaric oxygen therapy (HBOT), a therapy that have patients breath in pure oxygen in a pressurized chamber, has been long used as a treatment for conditions such as decompression sickness and carbon monoxide poisoning. Oxygen recently has been found to be an important component in skin rejuvenation, treatment of photoaging skin, and improvement in skin complexions. The interest in the use of HBOT for this purpose is continually growing and becoming more widespread. In addition to aging and genetic makeup, chronic UV radiation due to everyday exposure, especially UV-B, can greatly increase the rate of wrinkle formation through increasing skin angiogenesis and degradation of extracellular matrix molecules. The use of HBOT and hyperoxia conditions has been found to attenuate the formation of wrinkles from UV irradiation. It accomplishes the task by possibly inhibiting various processes and pathways involved such as the HIF1-α, VEGF, neutrophil infiltrations, and MMP-2 & MMP-9, which are directly involved with promoting skin angiogenesis in its active state. There are currently medical aesthetic clinics that are using oxygen therapy under high pressure applied directly to skin to reduce visible wrinkles but this procedure is not widespread yet due to more research that needs to be done on this topic. However, this treatment for wrinkles is definitely growing due to recent studies done showing the effectiveness of oxygen therapy on wrinkles. This review article will explore and summarize researches done on possible mechanisms dealing with the use of oxygen therapy for reduction of UVB-caused wrinkles, its side effects, and its possible future improvement and use in medicine. PMID:24690202

  16. Nested Shells Reveal the Rejuvenation of the Orion-Eridanus Superbubble

    NASA Astrophysics Data System (ADS)

    Ochsendorf, Bram B.; Brown, Anthony G. A.; Bally, John; Tielens, Alexander G. G. M.

    2015-08-01

    The Orion-Eridanus superbubble is the prototypical superbubble owing to its proximity and evolutionary state. Here we provide a synthesis of recent observational data from WISE and Planck with archival data, allowing us to draw a new and more complete picture on the history and evolution of the Orion-Eridanus region. We discuss the general morphological structures and observational characteristics of the superbubble and derive quantitative properties of the gas and dust inside Barnard’s Loop. We reveal that Barnard’s Loop is a complete bubble structure that, together with the λ Ori region and other smaller-scale bubbles, expands within the Orion-Eridanus superbubble. We argue that the Orion-Eridanus superbubble is larger and more complex than previously thought, and that it can be viewed as a series of nested shells, superimposed along the line of sight. During the lifetime of the superbubble, Hii region champagne flows and thermal evaporation of embedded clouds continuously mass-load the superbubble interior, while winds or supernovae from the Orion OB association rejuvenate the superbubble by sweeping up the material from the interior cavities in an episodic fashion, possibly triggering the formation of new stars that form shells of their own. The steady supply of material into the superbubble cavity implies that dust processing from interior supernova remnants is more efficient than previously thought. The cycle of mass loading, interior cleansing, and star formation repeats until the molecular reservoir is depleted or the clouds have been disrupted. While the nested shells come and go, the superbubble remains for tens of millions of years.

  17. Cybernetic principles of aging and rejuvenation: the buffering- challenging strategy for life extension.

    PubMed

    Heylighen, Francis

    2014-01-01

    Aging is analyzed as the spontaneous loss of adaptivity and increase in fragility that characterizes dynamic systems. Cybernetics defines the general regulatory mechanisms that a system can use to prevent or repair the damage produced by disturbances. According to the law of requisite variety, disturbances can be held in check by maximizing buffering capacity, range of compensatory actions, and knowledge about which action to apply to which disturbance. This suggests a general strategy for rejuvenating the organism by increasing its capabilities of adaptation. Buffering can be optimized by providing sufficient rest together with plenty of nutrients: amino acids, antioxidants, methyl donors, vitamins, minerals, etc. Knowledge and the range of action can be extended by subjecting the organism to an as large as possible variety of challenges. These challenges are ideally brief so as not to deplete resources and produce irreversible damage. However, they should be sufficiently intense and unpredictable to induce an overshoot in the mobilization of resources for damage repair, and to stimulate the organism to build stronger capabilities for tackling future challenges. This allows them to override the trade-offs and limitations that evolution has built into the organism's repair processes in order to conserve potentially scarce resources. Such acute, "hormetic" stressors strengthen the organism in part via the "order from noise" mechanism that destroys dysfunctional structures by subjecting them to strong, random variations. They include heat and cold, physical exertion, exposure, stretching, vibration, fasting, food toxins, micro-organisms, environmental enrichment and psychological challenges. The proposed buffering-challenging strategy may be able to extend life indefinitely, by forcing a periodic rebuilding and extension of capabilities, while using the Internet as an endless source of new knowledge about how to deal with disturbances. PMID:24852018

  18. Corticosteroid transdermal delivery to target swelling, edema and inflammation following facial rejuvenation procedures

    PubMed Central

    Iannitti, T; Rottigni, V; Palmieri, B

    2013-01-01

    Background and aim The use of transdermal therapeutic systems has spread worldwide since they allow effective local drug delivery. In the present study, we investigated the efficacy and safety of a new betamethasone valerate medicated plaster (Betesil®) to manage facial swelling, edema, inflammation, ecchymosis, and hematoma, when applied immediately after a facial rejuvenation procedure. Materials and methods We applied the plaster to the skin of 20 healthy patients for 12 hours immediately after hyaluronic acid-based procedure performed with the aim of erasing facial wrinkles of perioral and nasolabial folds and improving chin and eye contour. A further 20 patients underwent the same cosmetic procedure, but they were treated with an aescin 10% cream (applied immediately after the procedure, in the evening, and the morning after) and served as control group. Results Betesil® application resulted in a significant improvement in swelling/edema/inflammation score, if compared with aescin 10% cream (P < 0.01). As for facial ecchymosis and hematoma around the needle injection track, only two patients in the active treatment group displayed minimal ecchymosis and hematoma. In the control group, two patients presented minimal ecchymosis and three slight hematoma. However, using the ecchymosis/hematoma score, no significant difference between Betesil® and aescin 10% cream groups was observed. Patients’ satisfaction was significantly higher among subjects receiving Betesil®, if compared to patients receiving aescin 10% cream (P < 0.01). Conclusion The present study supports the use of Betesil® plaster immediately after facial cosmetic procedures in order to safely control swelling, edema, and inflammation. PMID:24101860

  19. 3 CFR 8416 - Proclamation 8416 of September 14, 2009. Fifteenth Anniversary of the Violence Against Women Act

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Anniversary of the Violence Against Women Act 8416 Proclamation 8416 Presidential Documents Proclamations Proclamation 8416 of September 14, 2009 Proc. 8416 Fifteenth Anniversary of the Violence Against Women ActBy... Nation's struggle to end violence against women. Authored by then United States Senator Joe Biden...

  20. 3 CFR 8611 - Proclamation 8611 of December 2, 2010. 40th Anniversary of the Environmental Protection Agency

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 3 The President 1 2011-01-01 2011-01-01 false Proclamation 8611 of December 2, 2010. 40th Anniversary of the Environmental Protection Agency 8611 Proclamation 8611 Presidential Documents Proclamations Proclamation 8611 of December 2, 2010 Proc. 8611 40th Anniversary of the Environmental Protection AgencyBy the President of the United States...

  1. 3 CFR 8613 - Proclamation 8613 of December 6, 2010. 50th Anniversary of the Arctic National Wildlife Refuge

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 3 The President 1 2011-01-01 2011-01-01 false Proclamation 8613 of December 6, 2010. 50th Anniversary of the Arctic National Wildlife Refuge 8613 Proclamation 8613 Presidential Documents Proclamations Proclamation 8613 of December 6, 2010 Proc. 8613 50th Anniversary of the Arctic National Wildlife RefugeBy the President of the United States...

  2. 3 CFR 8932 - Proclamation 8932 of February 1, 2013. 100th Anniversary of the Birth of Rosa Parks

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Anniversary of the Birth of Rosa Parks 8932 Proclamation 8932 Presidential Documents Proclamations Proclamation 8932 of February 1, 2013 Proc. 8932 100th Anniversary of the Birth of Rosa ParksBy the President... birth, we celebrate the life of a genuine American hero and remind ourselves that although the...

  3. 3 CFR 8636 - Proclamation 8636 of March 4, 2011. 150th Anniversary of the Inauguration of Abraham Lincoln

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 3 The President 1 2012-01-01 2012-01-01 false Proclamation 8636 of March 4, 2011. 150th Anniversary of the Inauguration of Abraham Lincoln 8636 Proclamation 8636 Presidential Documents Proclamations Proclamation 8636 of March 4, 2011 Proc. 8636 150th Anniversary of the Inauguration of Abraham LincolnBy the President of the United States...

  4. 3 CFR 8694 - Proclamation 8694 of July 25, 2011. Anniversary of the Americans With Disabilities Act, 2011

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 3 The President 1 2012-01-01 2012-01-01 false Proclamation 8694 of July 25, 2011. Anniversary of the Americans With Disabilities Act, 2011 8694 Proclamation 8694 Presidential Documents Proclamations Proclamation 8694 of July 25, 2011 Proc. 8694 Anniversary of the Americans With Disabilities Act, 2011By the President of the United States...

  5. 3 CFR 8691 - Proclamation 8691 of July 1, 2011. 40th Anniversary of the 26th Amendment

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 3 The President 1 2012-01-01 2012-01-01 false Proclamation 8691 of July 1, 2011. 40th Anniversary of the 26th Amendment 8691 Proclamation 8691 Presidential Documents Proclamations Proclamation 8691 of July 1, 2011 Proc. 8691 40th Anniversary of the 26th AmendmentBy the President of the United States of America A Proclamation Forty years ago,...

  6. 3 CFR 8542 - Proclamation 8542 of July 26, 2010. Anniversary of the Americans With Disabilities Act, 2010

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 3 The President 1 2011-01-01 2011-01-01 false Proclamation 8542 of July 26, 2010. Anniversary of the Americans With Disabilities Act, 2010 8542 Proclamation 8542 Presidential Documents Proclamations Proclamation 8542 of July 26, 2010 Proc. 8542 Anniversary of the Americans With Disabilities Act, 2010By the President of the United States...

  7. Neil Armstrong gets round of applaus at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong stands to a round of applause after being introduced at the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon. He appeared at the banquet with other former astronauts Edwin 'Buzz' Aldrin, Gene Cernan, Walt Cunningham and others.

  8. Former astronauts Armstrong and Cernan talk at Apollo 11 anniversary banquet

    NASA Technical Reports Server (NTRS)

    1999-01-01

    During an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible, former Apollo astronauts Neil Armstrong (left) and Gene Cernan talk about their experiences. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Edwin 'Buzz' Aldrin and Walt Cunningham. Neil Armstrong was the first man to walk on the moon; Gene Cernan was the last.

  9. Rejuvenation of agriculture in India: Cost benefits in using EO products

    NASA Astrophysics Data System (ADS)

    Jayaraman, V.; Parihar, J. S.; Srivastava, S. K.

    2008-07-01

    India is looking for rejuvenating its sagging agricultural production and productivity by integrating high technology space inputs for both irrigated and rainfed areas. The Earth Observations (EO) products today serve as major inputs to policy, planning and targeted interventions, contributing to building social capitals, natural resources assets and environmental gains on the long-term basis. The benefits are mostly indirect and often difficult to quantify in terms of money. The cost benefit analysis of EO products is therefore an involved exercise and not many examples exist globally. The present paper, taking into account major national as well as some local level agriprojects in India, highlights the criticality of EO products in terms of their short-term as well as long-term economic and social values. Three aspects viz., catalytic, timeliness and enabling have been analyzed to visualize the role of EO products in a holistic fashion. In the catalytic role, EO inputs have been found to play a role in the successful implementation of major natural resources development projects. The cost of EO inputs may be of less than 2-5% to the total cost of the development projects, but the nature of such inputs are critical and catalytic. For example, a major project on reclamation of around 0.6 Mha sodic soils in Indo-Gangetic Plans costs US89 million where EO products costs less than 2%; but demonstrates their catalytic roles in terms of identification, monitoring and evaluation and as inputs to mid-course corrections. The second aspect is timeliness in terms of opportunity cost. In India, Forecasting Agricultural Output Using Space-borne, Agro-meteorological and Land Observations (FASAL) project is carried out for in-season multiple crop production forecasting in support of strategic decision on trade, price and procurements. In the past, timely forecasts from FASAL have been found to be accurate and helpful for the country to plan many of its activities, including

  10. Probing the source and timing of rejuvenation and hybridization in post-caldera rhyolite magmas at Yellowstone Caldera

    NASA Astrophysics Data System (ADS)

    Till, C.; Vazquez, J. A.; Boyce, J. W.; Stelton, M. E.

    2013-12-01

    We find petrographic, isotopic and geochemical evidence for rejuvenation and recycling of subvolcanic intrusions within low δ18O intracaldera rhyolite lavas erupted following the formation of Yellowstone Caldera. In order to resolve the timing and compositional end-members involved in rejuvenation and hybridization of Yellowstone's subvolcanic magma reservoir, we have analyzed the Pb isotopic composition of clinopyroxene and sanidine phenocrysts and performed U-Pb dating of zircons from the South Biscuit Basin (SBB) and Scaup Lake (SCL) rhyolite lava flows. Both SBB and SCL erupted ca. 260 ka based on indistinguishable 40Ar/39Ar ages [1,2] and represent a renewed episode of postcaldera volcanism after a hiatus of ~200 kyr. Zoned phenocrysts of quartz, clinopyroxene, orthopyroxene, plagioclase, and sanidine and accessory zircon and Fe-Ti oxides characterize both SBB and SCL. SCL and SBB clinopyroxene have identical compositions and core-to-rim zoning patterns in Fe, Mg, and trace elements and commonly exhibit exsolution lamellae in their cores, suggesting that subsolidus conditions were attained during the early evolution of these rhyolites. The exsolution-bearing cores are mantled by a zone of relatively high Mg/Fe and low HREE & Rb, which is in turn overgrown by a rim with slightly lower Mg/Fe, and higher HREE & Rb. This zoning pattern suggests rejuvenation of subsolidus rhyolite by the influx of at least two less evolved, hotter silicic magmas. Diffusion modeling of Fe-Mg concentration profiles in clinopyroxene suggests that these events occurred on the order of 103 yrs prior to eruption. To identify the source of the rejuvenated rhyolite and delimit intra-grain variability, we analyzed the Pb-isotopic compositions of the SBB and SCL clinopyroxene zones via LA-MC-ICPMS. The different zones within SBB and SCL clinopyroxene yield indistinguishable Pb-isotope compositions with 208Pb/206Pb=2.165-2.185 and 207Pb/206Pb=0.882-0.890, which matches the Pb

  11. Quantifying the interval between rejuvenation and eruption of rhyolite at Yellowstone caldera using high-resolution NanoSIMS geospeedometry

    NASA Astrophysics Data System (ADS)

    Till, C. B.; Vazquez, J. A.; Boyce, J. W.; Hitzman, C.

    2012-12-01

    Rejuvenation of silicic intrusions by subsequent magmatic injections is implicated by an array of observations from petrography and geochronology, including disequilbrium mineral assemblages and xenocrysts. The time intervals between rejuvenation of a magma body and eruption are poorly known but recent studies suggest millenia. Geospeedometry of trace element zoning in single crystals is well suited to constrain such brief intervals but the short length scales of diffusion for most elements over such short timescales elude the spatial resolution of most in-situ analytical techniques. Here we quantify the time interval between rejuvention and eruption for the youngest episode of effusive volcanism at Yellowstone caldera using high-resolution ion-microprobe (NanoSIMS) geospeedometry, radioisotopic dating, and chemical analyses of single crystals. The Scaup Lake rhyolite lava flow (SCL) erupted ca. 257 ka after a volcanic hiatus of approximately 200 k.y. and is the youngest of the Upper Basin Member (UBM) intra-caldera effusive rhyolite lavas. SCL contains zoned phenocrysts of quartz, clinopyroxene, orthopyroxene, plagioclase, and sanidine with accessory zircon and Fe-Ti oxides. Exsolution lamellae in SCL pyroxenes suggest at least portions of this rhyolite cooled to subsolidus conditions during its evolution. Geothermometry indicates that crystals grew at a range of magma temperatures. Zircon rims yield an average Ti-in-zircon temperature of ~860°C (assuming aTiO2=0.5) whereas the zircon interiors yield temperatures of ~820°C, suggesting that the rims grew from hotter melts (or at aTiO2=0.7). Two feldspar thermometry indicates that feldspar rims grew at temperatures of 800-840°C and equilibrium Fe-Ti oxide pairs adjacent to groundmass glass suggest the magma erupted at temperatures of 750-840°C. SCL plagioclase and sanidine phenocrysts are characterized by rims with sharp boundaries that truncate internal zoning. These rims are enriched in Ba, Sr, and in some

  12. Pinpointing the onset of mechanical rejuvenation in a polymer glass by monitoring segmental dynamics before and after a constant strain rate pulse

    NASA Astrophysics Data System (ADS)

    Hebert, Kelly; Ricci, Josh; Suralik, Kelly; Ediger, M. D.

    Over time, dynamics in polymer glasses become slower through physical aging; it is thought that post-yield mechanical deformation may reverse the effects of physical aging in what has been termed ``rejuvenation''. We have monitored segmental dynamics in a poly(methyl methacrylate) glass before and after reversing constant strain rate pulses of varying magnitude to explore the onset of mechanical rejuvenation. We find that the segmental dynamics in the glass is unperturbed after pulses to ɛ/ɛyield = 0.6 or less. For pre-yield pulses of higher magnitude, we find evidence of rejuvenation, which is indicated by faster dynamics after the pulse. We find that full rejuvenation only occurs at a strain of ɛ/ɛyield = 3 or higher. This work is qualitatively consistent with recent simulations of Smessaert and Rottler and additionally shows quantitative agreement with predictions from the theory of Chen and Schweizer. However, in spite of observed enhanced dynamics on a molecular level, we find that large pre-yield pulses do not alter the mechanical response of the polymer during subsequent deformation. We explore the apparent contradiction between the macroscopic mechanical and molecular-level dynamical response of the glass to deformation. We are thankful for funding from NSF-DMR (1404614).

  13. The 1968 National Invitational Conference of School Psychologists: Is This the 41st Anniversary of NASP?

    ERIC Educational Resources Information Center

    Fagan, Tom

    2008-01-01

    With attention focused on NASP's 40th Anniversary and the coming Boston convention celebrations, some mention should be made of the organizational meeting that preceded NASP and laid the groundwork for its founding and first convention. Little has been written about the historic National Invitational Conference of School Psychologists, Thursday…

  14. 78 FR 53235 - 50th Anniversary of the March on Washington for Jobs and Freedom

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-28

    .... (Presidential Sig.) [FR Doc. 2013-21189 Filed 8-27-13; 11:15 am] Billing code 3295-F3 ... Documents#0;#0; ] Proclamation 9004 of August 23, 2013 50th Anniversary of the March on Washington for Jobs... remember that the March on Washington was a demonstration for jobs as well as freedom. The coalition...

  15. Parental Concerns in 100th Year Anniversary of Sociology Education in Turkey

    ERIC Educational Resources Information Center

    Kasapoglu, Aytul

    2016-01-01

    Although sociology education is celebrating its 100th year anniversary in Turkish higher education, the field itself is not known quite well by the society. Familial worries in the context of emotional sociology are very important because families may have when they think of their child's future especially after graduation from university. Primary…

  16. 77 FR 51473 - Safety Zone; Bostock 50th Anniversary Fireworks, Long Island Sound; Manursing Island, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Bostock 50th Anniversary Fireworks, Long... is establishing a temporary safety zone on the navigable waters of Long Island Sound in the vicinity... all vessels from a portion of Long Island Sound before, during, and immediately after the...

  17. 77 FR 34894 - Safety Zone; Bostock 50th Anniversary Fireworks, Long Island Sound; Manursing Island, NY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-12

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Bostock 50th Anniversary Fireworks, Long.... SUMMARY: The Coast Guard proposes to establish a temporary safety zone on the navigable waters of Long.... This rule is intended to restrict all vessels from a portion of Long Island Sound before, during,...

  18. A Network Sets Things in Motion: TEDD Celebrates its 5(th) Anniversary.

    PubMed

    2015-01-01

    At the Annual Meeting at ZHAW Waedenswil on 22 October 2015, the TEDD-Network (Tissue Engineering for Drug Development and Substance Testing) celebrated its 5(th) anniversary. Since its foundation, TEDD has become an internationally renowned competence centre and includes currently 91 members from academia and industry. They cover the entire development and value chain. PMID:26671055

  19. CAEL 2014 Forum and News: The Big 40th Anniversary Edition

    ERIC Educational Resources Information Center

    Bamford-Rees, Diana, Ed.; Doyle, Beth, Ed.; Klein-Collins, Becky, Ed.; Wertheim, Judith, Ed.

    2014-01-01

    The Council for Adult and Experiential Learning's (CAEL's) 40th anniversary year provided an opportunity for the "Forum and News" to examine the world of the adult learner from multiple perspectives and to invite CAEL friends and supporters to reflect on the evolution of the field and of CAEL as an organization. This publication presents…

  20. Sesame Street Research: A 20th Anniversary Symposium (Princeton, New Jersey, November 4, 1989).

    ERIC Educational Resources Information Center

    Mann, Peter B., Ed.

    A research agenda has been at the core of "Sesame Street" and other Children's Television Workshop (CTW) educational projects since inception. This collection of presentations, from a symposium honoring the twentieth anniversary of Sesame Street's debut on national television, addresses research's role in the series, describing how research is…

  1. 75 FR 33995 - Safety Zone; Michigan Orthopaedic Society 50th Anniversary Fireworks, Lake Huron, Mackinac Island...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Michigan Orthopaedic Society 50th... Society 50th Anniversary Fireworks display, June 19, 2010. This temporary safety zone is necessary to... vessels during the setup and launching of fireworks in conjunction with the Michigan Orthopaedic...

  2. Frontiers: Research Highlights 1946-1996 [50th Anniversary Edition. Argonne National Laboratory

    DOE R&D Accomplishments Database

    1996-01-01

    This special edition of 'Frontiers' commemorates Argonne National Laboratory's 50th anniversary of service to science and society. America's first national laboratory, Argonne has been in the forefront of U.S. scientific and technological research from its beginning. Past accomplishments, current research, and future plans are highlighted.

  3. Frontiers: Research highlights 1946-1996 [50th Anniversary Edition. Argonne National Laboratory

    SciTech Connect

    1996-12-31

    This special edition of 'Frontiers' commemorates Argonne National Laboratory's 50th anniversary of service to science and society. America's first national laboratory, Argonne has been in the forefront of U.S. scientific and technological research from its beginning. Past accomplishments, current research, and future plans are highlighted.

  4. Celebrating the 50th Anniversary of the "Merrill-Palmer Quarterly"

    ERIC Educational Resources Information Center

    Ladd, Gary W.

    2004-01-01

    The academic year 2004-2005 marks the 50th anniversary of the "Merrill-Palmer Quarterly: A Journal of Developmental Psychology." This occasion provides an opportunity to celebrate the journal's heritage, its long history of scholarly contributions to the human developmental sciences, and its current and future mission as a purveyor of scientific…

  5. 78 FR 8949 - 100th Anniversary of the Birth of Rosa Parks

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-06

    ... Parks's story did not end with the boycott she inspired. A lifelong champion of civil rights, she... we mark the 100th anniversary of Rosa Parks's birth, we celebrate the life of a genuine American hero... appropriate service, community, and education programs to honor Rosa Parks's enduring legacy. ] IN...

  6. The State of the World's Children, 1996 (50th Anniversary Issue).

    ERIC Educational Resources Information Center

    United Nations Children's Fund, New York, NY.

    This special issue of "The State of the World's Children" marks the 50th anniversary year of UNICEF and its work on behalf of children. Chapter 1 examines how wars and civil conflicts are taking an enormous toll on children. The chapter outlines a proposed anti-war agenda as a vital step to prevent and alleviate the suffering of children in armed…

  7. Living Room Pilgrimages: Television's Cyclical Commemoration of the Assassination Anniversary of John F. Kennedy.

    ERIC Educational Resources Information Center

    Vande Berg, Leah R.

    1995-01-01

    Offers a brief overview of V. Turner's syntactic and semantic framework for analyzing pilgrimage social drama. Uses this framework to examine the structure of the JFK assassination anniversary news stories and specials, as well as the fixed symbols which mark the pilgrimage routes from beginning to end. Discusses the individual, societal, and…

  8. 75 FR 50843 - 75th Anniversary of the Social Security Act

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-18

    ... From the Federal Register Online via the Government Publishing Office #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register / Vol. 75, No. 159 / Wednesday, August 18, 2010 / Presidential Documents#0;#0; #0; #0;Title 3-- #0;The President ] Proclamation 8546 of August 13, 2010 75th Anniversary of the Social Security Act By the President of the United States...

  9. MedlinePlus en español marks its 10th anniversary

    MedlinePlus

    ... medlineplus.gov/spanishanniversary.html MedlinePlus en español Marks its 10 th Anniversary To use the sharing features ... Spanish greatly expands NIH's ability to carry out its mission to communicate with the public.” MedlinePlus en ...

  10. The White House: 200th Anniversary. Save Our History[TM]. Teacher's Manual, Grades K-12.

    ERIC Educational Resources Information Center

    Maxwell, Louise P.; O'Connell, Libby Haight; Rosenberg, Jessica; Troster, Sara Kahn

    The 200th Anniversary of the White House provides a creative spring board for studying history through a variety of disciplines. Art, music, geography, literature, and language arts curriculum requirements can be integrated into different eras of White House history. For each grade level, this teacher's manual includes readings, discussion…

  11. Flight Operations reunion for the Apollo 11 20th anniversary of the first manned lunar landing

    NASA Technical Reports Server (NTRS)

    1989-01-01

    The following major areas are presented: (1) the Apollo years; (2) official flight control manning list for Apollo 11; (3) original mission control emblem; (4) foundations of flight control; (5) Apollo-11 20th anniversary program and events; (6) Apollo 11 mission operations team certificate; (7) Apollo 11 mission summary (timeline); and (8) Apollo flight control team photographs and biographies.

  12. 75 FR 44877 - Anniversary of the Americans With Disabilities Act, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ... From the Federal Register Online via the Government Publishing Office ] Part III The President Proclamation 8542--Anniversary of the Americans With Disabilities Act, 2010 #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register / Vol. 75, No. 145 / Thursday, July 29, 2010 / Presidential Documents#0;#0; #0; #0;Title 3-- #0;The President ] Proclamation 8542...

  13. Pre-eruptive conditions in the Wah Wah Springs Tuff: No Evidence of Thermal Rejuvenation

    NASA Astrophysics Data System (ADS)

    Woolf, K. S.; Christiansen, E. H.; Best, M. G.; Dorais, M. J.

    2008-12-01

    which decrease as much as 2.5 wt% and 1 wt%, respectively, from cores to rims. These zoning patterns are consistent with a decrease of temperature during crystallization of these phases. We find no low Al- hornblendes (Altotal =0.9 and 1.1 apfu) like those in the Fish Canyon, which were interpreted to be low temperature, near-solidus phases. Moreover, orthopyroxene is found only embedded in hornblende, apparently as a result of a down temperature reaction with melt. Resorption of quartz and plagioclase was probably the result of decompression of the water-undersaturated magma during eruption. Thus, we see no evidence that the Wah Wah magma was a near-solidus magma body that was "rejuvenated" or reheated immediately prior to eruption as proposed by Bachman et al., (2002) for the Fish Canyon Tuff. Pre-eruptive melting does not seem to be a necessary prerequisite for caldera collapse and eruption of very large bodies of magma.

  14. Optimizing facial rejuvenation outcomes by combining poly-L-lactic acid, hyaluronic acid, calcium hydroxylapatite, and neurotoxins: two case studies.

    PubMed

    Lorenc, Z Paul; Daro-Kaftan, Elizabeth

    2014-02-01

    Reversal of the visible signs of facial aging with the use of injectable products as an alternative to surgery has become more popular, with nearly 5 million procedures performed in the United States in 2012. Volume augmentation products, such as hyaluronic acid (HA), calcium hydroxylapatite (CaHA), and poly-L-lactic acid (PLLA), are often used in combination with one another and with neurotoxins for facial rejuvenation because of the complementary modes of action. This article presents 2 case reports involving patientspecific combinations of 2 different HA products, injectable PLLA, and CaHA with incobotulinumtoxinA or abobotulinumtoxinA. The combination of HA, CaHA, PLLA, and neurotoxins has resulted in outstanding outcomes for many patients, with no clinical evidence of increased adverse events secondary to combination therapy. PMID:24509971

  15. 3 CFR 8886 - Proclamation 8886 of October 9, 2012. 50th Anniversary of the Office of the United States Trade...

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... strategy for an economy built to last. On this anniversary, we recognize the dedicated professionals who... best place in the world to innovate, invest, work, and build a business. NOW, THEREFORE, I,...

  16. The 30th Anniversary of the First Reported Cases of AIDS | NIH MedlinePlus the Magazine

    MedlinePlus

    ... Javascript on. Feature: 30 Years of AIDS Research The 30th Anniversary of the First Reported Cases of AIDS Past Issues / Summer ... Contents Dr. Jack Whitescarver Dr. Anthony S. Fauci In the 30 years since the first reported cases of ...

  17. The 2009 Apparition of methuselah comet 107P/Wilson-Harrington: A case of comet rejuvenation?

    NASA Astrophysics Data System (ADS)

    Ferrín, Ignacio; Hamanowa, Hiromi; Hamanowa, Hiroko; Hernández, Jesús; Sira, Eloy; Sánchez, Albert; Zhao, Haibin; Miles, Richard

    2012-09-01

    detectors than on 1949. This is good evidence to conclude that this object is very near extinction and belongs to the graveyard of comets. In a Remaining Revolutions vs. Water-Budget Age plot, we have identified the region of the graveyard, and 107P is a member of this group. (8) Using the amplitude of the secular light curve (ASEC) vs. Diameter (DEFFE) diagram (Fig. 15), we show that 107P is the most evolved object in the current data base of comets. In the classification scheme of Ferrín (PSS, 58, 365-391, 2010), 107P is a methuselah comet (WB-AGE=7800>100 comet years), medium size (1.4rejuvenated due to a trend of apparitions with decreasing perihelion distances. (9) Since the general flow of the sample is down and to the left in the ASEC vs. DEFFE diagram, and since this flow has been going on for centuries, and since dwarf comets evolve much more rapidly than large comets, the existence of a significant population of dormant and extinct comets located in the lower left region of the diagram is predicted. This is the graveyard. Three comets have been identified as members of the graveyard, 107P, 133P and D/1891W1 Blanpain.

  18. NASA Administrator Dan Goldin greets Neil Armstrong at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    During an anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible, former Apollo astronaut Neil A. Armstrong (left) shakes the hand of Judy Goldin (center), wife of NASA Administrator Daniel S. Goldin (right). The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin 'Buzz' Aldrin who flew on Apollo 11, the launch of the first moon landing; Gene Cernan, who flew on Apollo 10 and 17 and was the last man to walk on the moon; and Walt Cunningham, who flew on Apollo 7.

  19. Coping with the 10th anniversary of 9/11: Muslim Americans' sadness, fear, and anger.

    PubMed

    Rodriguez Mosquera, Patricia M; Khan, Tasmiha; Selya, Arielle

    2013-01-01

    The events of 9/11 marked an increase in prejudice, discrimination, and other forms of unfair treatment toward Muslim Americans. We present a study that examined the emotions of Muslim Americans in the days preceding the ten-year 9/11 anniversary. We measured the antecedents (concerns) and consequences (coping) of sadness, fear, and anger. The 9/11 anniversary precipitated intense concerns with loss and discrimination, and intense feelings of sadness, fear, and anger. We measured three coping responses: rumination, avoidance of public places, and religious coping. Participants engaged in all three coping responses, with seeking solace in one's religion being the most frequent response. Moreover, emotions mediated the relationship between concerns and coping responses. Sadness accounted for the association between concern with loss and rumination. Fear explained the association between concern with discrimination and avoidance. Anger accounted for the association between concern with discrimination and religious coping. PMID:23237357

  20. Medicine and Human Rights: Reflections on the Fiftieth Anniversary of the Doctors' Trial.

    PubMed

    Annas; Grodin

    1996-01-01

    1996 marks the fiftieth anniversary of the commencement of the trial of Nazi physicians at Nuremberg, a trial that has been variously designated as the "Doctors' Trial" and the "Medical Case." In addition to documenting atrocities committed by physicians and scientists during WWII, the most significant contribution of the trial has come to be known as the "Nuremberg Code," a judicial codification of 10 prerequisites for the moral and legal use of human beings in experiments. Anniversaries provide us with an opportunity to reflect upon the past, but they also enable us to renew our efforts to plan for the future. This article describes briefly the historical evolution of the Nuremberg Code, discusses its current relevance and applicability by using a case study example, and proposes future steps to be taken by the international community. PMID:10393627

  1. Unspiked K Ar dating of the Honolulu rejuvenated and Ko‘olau shield volcanism on O‘ahu, Hawai‘i

    NASA Astrophysics Data System (ADS)

    Ozawa, Ayako; Tagami, Takahiro; Garcia, Michael O.

    2005-03-01

    Many mantle plume volcanoes undergo rejuvenated volcanism after a period of construction and erosion of their shield. The cause of this renewed volcanism has been enigmatic and various models have been proposed. However, the lack of geochronological data has hindered evaluation of these models. Unspiked K-Ar ages on groundmass in 41 samples from 32 vents of Honolulu Volcanics and eight samples of underlying Ko'olau Volcanics were determined in order to reveal the temporal distribution of rejuvenated vents and the length of the hiatus between the end of shield and start of rejuvenated volcanism. The new geochronological results show that Ko'olau shield volcanism ended at 2.1 Ma and that rejuvenated volcanism started at 0.8 Ma, resulting in a 1.3 million year hiatus in volcanic activity. Two distinct pulses were found for Honolulu volcanism at 0.80-0.35 and ˜0.1 Ma. During the first pulse, the eruption frequency increased with time and there was no spatial pattern in vent distribution, although three vents along a NNE-SSW trend produced similar compositions and may have been coeval. Volcanism apparently waned from 0.35-0.12 Ma, with only one eruption. The second pulse occurred along two rifts that trend N-S and NE-SW. Although the ages for the 10 dated flows are indistinguishable at around 0.1 Ma, lavas from the two rifts have distinct compositions: weakly alkalic vs. melilite nephelinite. The first, more widely distributed pulse of volcanism is probably related to secondary melting downstream from the Hawaiian plume stem, which may be related to lithospheric thinning. The second pulse, focused along two rifts, may be related to decompressional melting as the shield passed over the flexural arch.

  2. Comparison study of intense pulsed light versus a long-pulse pulsed dye laser in the treatment of facial skin rejuvenation.

    PubMed

    Kono, Taro; Groff, William Frederick; Sakurai, Hiroyuki; Takeuchi, Masaki; Yamaki, Takashi; Soejima, Kazutaka; Nozaki, Motohiro

    2007-11-01

    Currently, various nonablative skin resurfacing techniques are being used to rejuvenate facial skin, including lasers and intense pulsed light (IPL). There are few direct comparison studies between IPLs and lasers. The objective of our study is to compare the effectiveness of intense pulsed light versus a long-pulse pulsed dye laser (LPDL) in the treatment of facial skin rejuvenation. Ten Asian patients with Fitzpatrick skin types III-IV were enrolled in this study. One half of the face was treated with IPL (6 treatment sessions) and the other side was treated by LPDL (3 treatment sessions). An LPDL with a wavelength of 595 nm and spot size of 7 mm was used. Utilizing the compression method, lentigines were treated using a PDL with a fluence between 9-12 J/cm and a pulse duration of 1.5 ms. Wrinkles were treated with fluences between 10 to 12 J/cm and a pulse duration of 20 ms, using a pulse-stacking technique. An IPL with a type B handpiece was used. Lentigines and wrinkles were treated with fluences between 27 to 40 J/cm and a pulse duration of 20 ms. The improvement of lentigines was 62.3% and 81.1% for IPL and LPDL respectively. There was no significant difference between IPL and LPDL in wrinkle reduction. There was no scarring or pigmentary change seen with either device. Both IPL and LPDL are effective for facial skin rejuvenation in Asians, but LPDL treatment is significantly better than IPL treatment in the treatment of lentigines. The use of the compression technique may allow this LPDL to be used effectively for facial rejuvenation and with fewer treatment sessions, when compared with the IPL. PMID:17992138

  3. The 1868 Hayward Earthquake Alliance: A Case Study - Using an Earthquake Anniversary to Promote Earthquake Preparedness

    NASA Astrophysics Data System (ADS)

    Brocher, T. M.; Garcia, S.; Aagaard, B. T.; Boatwright, J. J.; Dawson, T.; Hellweg, M.; Knudsen, K. L.; Perkins, J.; Schwartz, D. P.; Stoffer, P. W.; Zoback, M.

    2008-12-01

    Last October 21st marked the 140th anniversary of the M6.8 1868 Hayward Earthquake, the last damaging earthquake on the southern Hayward Fault. This anniversary was used to help publicize the seismic hazards associated with the fault because: (1) the past five such earthquakes on the Hayward Fault occurred about 140 years apart on average, and (2) the Hayward-Rodgers Creek Fault system is the most likely (with a 31 percent probability) fault in the Bay Area to produce a M6.7 or greater earthquake in the next 30 years. To promote earthquake awareness and preparedness, over 140 public and private agencies and companies and many individual joined the public-private nonprofit 1868 Hayward Earthquake Alliance (1868alliance.org). The Alliance sponsored many activities including a public commemoration at Mission San Jose in Fremont, which survived the 1868 earthquake. This event was followed by an earthquake drill at Bay Area schools involving more than 70,000 students. The anniversary prompted the Silver Sentinel, an earthquake response exercise based on the scenario of an earthquake on the Hayward Fault conducted by Bay Area County Offices of Emergency Services. 60 other public and private agencies also participated in this exercise. The California Seismic Safety Commission and KPIX (CBS affiliate) produced professional videos designed forschool classrooms promoting Drop, Cover, and Hold On. Starting in October 2007, the Alliance and the U.S. Geological Survey held a sequence of press conferences to announce the release of new research on the Hayward Fault as well as new loss estimates for a Hayward Fault earthquake. These included: (1) a ShakeMap for the 1868 Hayward earthquake, (2) a report by the U. S. Bureau of Labor Statistics forecasting the number of employees, employers, and wages predicted to be within areas most strongly shaken by a Hayward Fault earthquake, (3) new estimates of the losses associated with a Hayward Fault earthquake, (4) new ground motion

  4. The Fish Canyon magma body, San Juan volcanic field, Colorado: Rejuvenation and eruption of an upper-crustal batholith

    USGS Publications Warehouse

    Bachmann, Olivier; Dungan, M.A.; Lipman, P.W.

    2002-01-01

    More than 5000 km3 of nearly compositionally homogeneous crystalrich dacite (~68 wt % SiO2: ~45% Pl + Kfs + Qtz + Hbl + Bt + Spn + Mag + Ilm + Ap + Zrn + Po) erupted from the Fish Canyon magma body during three phases: (1) the pre-caldera Pagosa Peak Dacite (an unusual poorly fragmented pyroclastic deposit, ~ 200 km3); (2) the syn-collapse Fish Canyon Tuff (one of the largest known ignimbrites, ~ 5000 km3); (3) the post-collapse Nutras Creek Dacite (a volumetrically minor lava). The late evolution of the Fish Canyon magma is characterized by rejuvenation of a near-solidus upper-crustal intrusive body (mainly crystal mush) of batholithic dimensions. The necessary thermal input was supplied by a shallow intrusion of more mafic magma represented at the surface by sparse andesitic enclaves in late-erupted Fish Canyon Tuff and by the post-caldera Huerto Andesite. The solidified margins of this intrusion are represented by holocrystalline xenoliths with Fish Canyon mineralogy and mineral chemistry and widely dispersed partially remelted polymineralic aggregates, but dehydration melting was not an important mechanism in the rejuvenation of the Fish Canyon magma. Underlying mafic magma may have evolved H2O-F-S-Cl-rich fluids that fluxed melting in the overlying crystal mush. Manifestations of the late up-temperature magma evolution are: (1) resorbed quartz, as well as feldspars displaying a wide spectrum of textures indicative of both resorption and growth, including Rapakivi textures and reverse growth zoning (An27-28 to An32-33) at the margins of many plagioclase phenocrysts; (2) high Sr, Ba, and Eu contents in the high-SiO2 rhyolite matrix glass, which are inconsistent with extreme fractional crystallization of feldspar; (3) oscillatory and reverse growth zoning toward the margins of many euhedral hornblende phenocrysts (rimward increases from ~5??5-6 to 7??7-8??5 wt % Al2O3). Homogeneity in magma composition at the chamber-wide scale, contrasting with extreme textural

  5. Quinic acid could be a potential rejuvenating natural compound by improving survival of Caenorhabditis elegans under deleterious conditions.

    PubMed

    Zhang, Longze; Zhang, Junjing; Zhao, Baolu; Zhao-Wilson, Xi

    2012-12-01

    Quinic acid (QA) is an active ingredient of Cat's Claw (Uncaria tomentosa), which is found to be active in enhancing DNA repair and immunity in model systems and able to generate neuroprotective effects in neurons. However, QA's role in improving survival is not well studied. Here we report that QA can provide protection in Caenorhabidits elegans and improve worm survival under stress. Under heat stress and oxidative stress, QA-treated wild-type C. elegans N2 (N2) survived 17.8% and 29.7% longer, respectively, than the control worms. Our data suggest that under heat stress, QA can upregulate the expression of the small heat shock protein hsp-16.2 gene, which could help the worms survive a longer time. We also found that QA extended the C. elegans mutant VC475 [hsp-16.2 (gk249)] life span by 15.7% under normal culture conditions. However, under normal culture conditions, QA did not affect hsp-16.2 expression, but upregulated the expression of daf-16 and sod-3 in a DAF-16-dependent manner, and downregulated the level of reactive oxygen species (ROS), suggesting that under normal conditions QA acts in different pathways. As a natural product, QA demonstrates great potential as a rejuvenating compound. PMID:22950425

  6. Mapping colors from paintings to tapestries: rejuvenating the faded colors in tapestries based on colors in reference paintings

    NASA Astrophysics Data System (ADS)

    Ström, Marie; Johansson, Eija; Stork, David G.

    2012-03-01

    We addressed the problem of recovering or "rejuvenating" colors in a faded tapestry (the target image) by automatically mapping colors from digital images of the reference painting or cartoon (the source image). We divided the overall computational challenge into several subproblems, and implemented their solutions in Matlab: 1) quantizing the colors in both the tapestry and the referent painting, 2) matching corresponding regions in the works based on spatial location, area and color, 3) mapping colors from regions in the source image to corresponding regions in the target image, and 4) estimating the fading of colors and excluding color mapping of areas where color has not faded. There are a number of semi-global design parameters in our algorithm, which we currently set by hand, for instance the parameter that balance the effects of 1) matching color areas in the two images and 2) matching the spatial locations between the two images. We demonstrated our method on synthetic data and on small portions of 16th-century European tapestries of cultural patrimony. Our first steps in a proof-of-concept work suggest that future refinements to our method will lead to a software tool of value to art scholars.

  7. Quinic Acid Could Be a Potential Rejuvenating Natural Compound by Improving Survival of Caenorhabditis elegans under Deleterious Conditions

    PubMed Central

    Zhang, Longze; Zhang, Junjing

    2012-01-01

    Abstract Quinic acid (QA) is an active ingredient of Cat's Claw (Uncaria tomentosa), which is found to be active in enhancing DNA repair and immunity in model systems and able to generate neuroprotective effects in neurons. However, QA's role in improving survival is not well studied. Here we report that QA can provide protection in Caenorhabidits elegans and improve worm survival under stress. Under heat stress and oxidative stress, QA-treated wild-type C. elegans N2 (N2) survived 17.8% and 29.7% longer, respectively, than the control worms. Our data suggest that under heat stress, QA can upregulate the expression of the small heat shock protein hsp-16.2 gene, which could help the worms survive a longer time. We also found that QA extended the C. elegans mutant VC475 [hsp-16.2 (gk249)] life span by 15.7% under normal culture conditions. However, under normal culture conditions, QA did not affect hsp-16.2 expression, but upregulated the expression of daf-16 and sod-3 in a DAF-16–dependent manner, and downregulated the level of reactive oxygen species (ROS), suggesting that under normal conditions QA acts in different pathways. As a natural product, QA demonstrates great potential as a rejuvenating compound. PMID:22950425

  8. Neil Armstrong talks of his experiences at Apollo 11 anniversary banquet

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Neil Armstrong, former Apollo 11 astronaut, and first man to walk on the moon, talks about his experiences for an enthusiastic audience at the Apollo/Saturn V Center, part of the KSC Visitor Complex. The occasion was a banquet celebrating the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among other guests at the banquet were astronauts Wally Schirra, Edwin 'Buzz' Aldrin and Walt Cunningham. Gene Cernan was the last man to walk on the moon.

  9. Leonid Vital'evich Kantorovich (on the 100th anniversary of his birth)

    NASA Astrophysics Data System (ADS)

    Vershik, Anatolii M.; Kutateladze, Semen S.; Novikov, Sergei P.

    2012-06-01

    The 19th of January 2012 was the 100th anniversary of the birth of Leonid Vital'evich Kantorovich, an outstanding mathematician and economist of international fame. A child prodigy, who graduated from the university at 18 and became a professor at 20, an academician in the mathematical sciences and a laureate of the Nobel Prize in economics, - these are extraordinary circumstances of his life. They are remarkable in themselves, but also the results he achieved were exceptional and immensely impressive, and the younger generations of researchers, first and foremost mathematicians and economists, must know about them.

  10. Localized rejuvenation of a crystallizing pluton recorded in zircon from the Lassen Volcanic Center, southern Cascade Range, California

    NASA Astrophysics Data System (ADS)

    Klemetti, E. W.; Clynne, M. A.; Ring, M.; Bertolett, E. M.

    2013-12-01

    LVC lavas show a strong signature of plagioclase fractionation with low Eu/Eu* (0.28-0.42) and lower temperature (669-753°C, derived from Ti-in-zircon thermometry). A subordinate population of zircon have warmer crystallization temperatures (696-803°C) with higher Eu/Eu* (0.30-0.74) and appears starting at ~130 ka. These likely represent localized rejuvenation of the rheologically solid Bumpass proto-pluton where basaltic influx heats parts of the crystallizing pluton. This creates a thermal instability that rises as a diapir through the mush after mixing of the basaltic and felsic endmembers. After eruption, the system as a whole has not felt a dramatic thermal perturbation across its entirety, but only in localized areas of remobilization. Most cooler zircons are derived from major phase crystals (plagioclase, biotite) scavenged from the crystal mush (proto-pluton) and new warmer zircon are from the rejuvenated melt. This likely represents the early stages of development of magmatic textures and structures (diapirs, pipes, plumes) observed in fully crystalline plutons.

  11. Broken ergodicity, memory effect, and rejuvenation in Taylor-phase and decagonal Al3(Mn,Pd,Fe) complex intermetallics

    NASA Astrophysics Data System (ADS)

    Dolinšek, J.; Slanovec, J.; Jagličić, Z.; Heggen, M.; Balanetskyy, S.; Feuerbacher, M.; Urban, K.

    2008-02-01

    The Taylor-phase complex intermetallic compound T-Al3Mn , its solid solutions with Pd and Fe, T-Al3(Mn,Pd) and T-Al3(Mn,Fe) , and the related decagonal d-Al-Mn-Fe quasicrystal belong to the class of magnetically frustrated spin systems that exhibit rich out-of-equilibrium spin dynamics in the nonergodic phase below the spin-freezing temperature Tf . Performing large variety of magnetic experiments as a function of temperature, magnetic field, aging time tw , and different thermal histories, we investigated broken-ergodicity phenomena of (i) a difference in the field-cooled and zero-field-cooled susceptibilities, (ii) the frequency-dependent freezing temperature, Tf(ν) , (iii) hysteresis and remanence, (iv) ultraslow decay of the thermoremanent magnetization, (v) the memory effect (a state of the spin system reached upon isothermal aging can be retrieved after a negative temperature cycle), and (vi) “rejuvenation” (small positive temperature cycle within the nonergodic phase erases the effect of previous aging). We show that the phenomena involving isothermal aging periods (the memory effect, rejuvenation, and the ultraslow decay of the thermoremanent magnetization) get simple explanation by considering that during aging under steady external conditions, localized spin regions quasiequilibrate into more stable configurations, so that higher thermal energy is needed to destroy these regions by spin flipping, as compared to the thermal energy required to reverse a frustrated spin in a disordered spin-glass configuration that forms in the case of no aging. Common to all the investigated broken-ergodicity phenomena is the slow approach of a magnetically frustrated spin system toward a global equilibrium, which can never be reached on accessible experimental time scales due to macroscopic equilibration times.

  12. NGC 404: A REJUVENATED LENTICULAR GALAXY ON A MERGER-INDUCED, BLUEWARD EXCURSION INTO THE GREEN VALLEY

    SciTech Connect

    Thilker, David A.; Bianchi, Luciana; Schiminovich, David; Gil de Paz, Armando; Wyder, Ted; Barlow, Tom; Conrow, Tim; Forster, Karl; Friedman, Peter; Martin, Chris; Morrissey, Patrick; Small, Todd; Rich, R. Michael; Yi, Sukyoung; Neff, Susan

    2010-05-01

    We have discovered recent star formation in the outermost portion ((1-4) x R {sub 25}) of the nearby lenticular (S0) galaxy NGC 404 using Galaxy Evolution Explorer UV imaging. FUV-bright sources are strongly concentrated within the galaxy's H I ring (formed by a merger event according to del RIo et al.), even though the average gas density is dynamically subcritical. Archival Hubble Space Telescope imaging reveals resolved upper main-sequence stars and conclusively demonstrates that the UV light originates from recent star formation activity. We present FUV, NUV radial surface brightness profiles, and integrated magnitudes for NGC 404. Within the ring, the average star formation rate (SFR) surface density ({Sigma}{sub SFR}) is {approx}2.2 x 10{sup -5} M {sub sun} yr{sup -1} kpc{sup -2}. Of the total FUV flux, 70% comes from the H I ring which is forming stars at a rate of 2.5 x 10{sup -3} M {sub sun} yr{sup -1}. The gas consumption timescale, assuming a constant SFR and no gas recycling, is several times the age of the universe. In the context of the UV-optical galaxy color-magnitude diagram, the presence of the star-forming H I ring places NGC 404 in the green valley separating the red and blue sequences. The rejuvenated lenticular galaxy has experienced a merger-induced, disk-building excursion away from the red sequence toward bluer colors, where it may evolve quiescently or (if appropriately triggered) experience a burst capable of placing it on the blue/star-forming sequence for up to {approx}1 Gyr. The green valley galaxy population is heterogeneous, with most systems transitioning from blue to red but others evolving in the opposite sense due to acquisition of fresh gas through various channels.

  13. Abrogation of Age-Induced MicroRNA-195 Rejuvenates the Senescent Mesenchymal Stem Cells by Reactivating Telomerase.

    PubMed

    Okada, Motoi; Kim, Ha Won; Matsu-ura, Kaoru; Wang, Yi-Gang; Xu, Meifeng; Ashraf, Muhammad

    2016-01-01

    Previously, we reported that a novel subpopulation of young mesenchymal stem cells (YMSCs) existed in old bone marrow, which possessed high antiaging properties as well as excellent efficacy for cardiac repair. MicroRNAs (miRNAs) have emerged as key regulators in post-transcriptional gene expression programs, and however, it is unknown whether miRNAs directly control stem cell senescence. Here we present the first evidence that miR-195 overexpressed in old MSCs (OMSCs) induces stem cell senescence deteriorating their regenerative ability by directly deactivating telomerase reverse transcriptase (Tert), and abrogation of miR-195 can reverse stem cell aging. MiRNAs profiling analysis in YMSCs and OMSCs by microarray showed that miR-140, miR-146a/b, and miR-195 were significantly upregulated in OMSCs, which led us to hypothesize that these are age-induced miRNAs involved in stem cell senescence. Of these miRNAs, we found miR-195 directly targeted 3'-untranslated region of Tert gene by computational target prediction analysis and luciferase assay, and knockdown of miR-195 significantly increased Tert expression in OMSCs. Strikingly, miR-195 inhibition significantly induced telomere relengthening in OMSCs along with reduced expression of senescence-associated β-galactosidase. Moreover, silencing miR-195 in OMSCs by transfection of miR-195 inhibitor significantly restored antiaging factors expression including Tert and Sirt1 as well as phosphorylation of Akt and FOXO1. Notably, abrogation of miR-195 markedly restored proliferative abilities in OMSCs. Transplantation of OMSCs with knocked out miR-195 reduced infarction size and improved LV function. In conclusion, rejuvenation of aged stem cells by miR-195 inhibition would be a promising autologous therapeutic strategy for cardiac repair in the elderly patients. PMID:26390028

  14. Ascorbate-dependent impact on cell-derived matrix in modulation of stiffness and rejuvenation of infrapatellar fat derived stem cells toward chondrogenesis.

    PubMed

    Pizzute, Tyler; Zhang, Ying; He, Fan; Pei, Ming

    2016-01-01

    Developing an in vitro microenvironment using cell-derived decellularized extracellular matrix (dECM) is a promising approach to efficiently expand adult stem cells for cartilage engineering and regeneration. Ascorbic acid serves as a critical stimulus for cells to synthesize collagens, which constitute the major component of dECM. In this study, we hypothesized that optimization of ascorbate treatment would maximize the rejuvenation effect of dECM on expanded stem cells from human infrapatellar fat pad in both proliferation and chondrogenic differentiation. In the duration regimen study, we found that dECM without L-ascorbic acid phosphate (AA) treatment, exhibiting lower stiffness measured by atomic force microscopy, yielded expanded cells with higher proliferation capacity but lower chondrogenic potential when compared to those with varied durations of AA treatment. dECM with 250 µM of AA treatment for 10 d had better rejuvenation in chondrogenic capacity if the deposited cells were from passage 2 rather than passage 5, despite no significant difference in matrix stiffness. In the dose regimen study, we found that dECMs deposited by varied concentrations of AA yielded expanded cells with higher proliferation capacity despite lower expression levels of stem cell related surface markers. Compared to cells expanded on tissue culture polystyrene, those on dECM exhibited greater chondrogenic potential, particularly for the dECMs with 50 µM and 250 µM of AA treatment. With the supplementation of ethyl-3,4-dihydroxybenzoate (EDHB), an inhibitor targeting procollagen synthesis, the dECM with 50 µM of AA treatment exhibited a dramatic decrease in the rejuvenation effect of expanded cell chondrogenic potential at both mRNA and protein levels despite no significant difference in matrix stiffness. Defined AA treatments during matrix preparation will benefit dECM-mediated stem cell engineering and future treatments for cartilage defects. PMID:27508528

  15. Intense pulsed light, near infrared pulsed light, and fractional laser combination therapy for skin rejuvenation in Asian subjects: a prospective multi-center study in China.

    PubMed

    Tao, Li; Wu, Jiaqiang; Qian, Hui; Lu, Zhong; Li, Yuanhong; Wang, Weizhen; Zhao, Xiaozhong; Tu, Ping; Yin, Rui; Xiang, Leihong

    2015-09-01

    Ablative skin rejuvenation therapies have limitations for Asian people, including post-inflammatory hyperpigmentation and long down time. Non-ablative lasers are safer but have limited efficacy. This study is to investigate the safety and efficacy of a combination therapy consisting of intense pulsed light (IPL), near infrared (NIR) light, and fractional erbium YAG (Er:YAG) laser for skin rejuvenation in Asian people. This study recruited 113 subjects from six sites in China. Subjects were randomly assigned to a full-face group, who received combination therapy, and split-face groups, in which one half of the face received combination therapy and the other half received IPL monotherapy. Each subject received five treatment sessions during a period of 90 days. Subjects were followed up at 1 and 3 months post last treatment. Three months after last treatment, the full-face group (n = 57) had a global improvement rate of 29 % and 29 % for wrinkles, 32 % for skin texture, 33 % for pigment spots, 28 % for pore size, respectively. For patients in the split-face groups (n = 54), monotherapy side had a global improvement rate of 23 % and 20 % for wrinkles, 27 % for skin texture, 25 % for pigment spots, 25 % for pore size, respectively. Both combination therapy and monotherapy resulted in significant improvements at the follow-up visits compared to baseline (P < 0.001). Combination therapy showed significantly greater improvements compared to monotherapy at two follow-up visits (P < 0.05). Combination therapy is a safe and more effective strategy than IPL monotherapy for skin rejuvenation in Asian people. PMID:26266401

  16. Cooling Before Super-Eruption: No Evidence of Rejuvenation in a Crystal-Rich Dacite Magma Body, Southern Great Basin Ignimbrite Province, Utah and Nevada

    NASA Astrophysics Data System (ADS)

    Ross, K. T.; Christiansen, E. H.; Best, M. G.; Dorais, M.

    2015-12-01

    The model of rejuvenation of a near-solidus crystal mush to produce large volumes of crystal-rich magma is tested here by analyzing the mineralogical, chemical, modal, and physical characteristics of the 31.1 Ma super-eruptive (2000 km3) Cottonwood Wash Tuff. It is the oldest in a series of three so-called "monotonous intermediate" ignimbrites from the Indian Peak-Caliente volcanic field in southern Utah and Nevada. A crystal-rich (~50% Pl + Qz + Hbl + Bt + Mag + Ilm + Cpx + Zrn + Ap + Po) dacite (62 - 69 wt% SiO2), the Cottonwood Wash Tuff is similar in age, volume, mineralogy, crystallinity, and elemental composition to the 28.0 Ma, ~5000 km3 Fish Canyon Tuff (~45% Pl + Kfs + Qz + Hbl + Bt + Ttn + Mag + Ilm + Ap + Zrn + Po, 66 - 68 wt% SiO2), used as the basis of the rejuvenation model. The Cottonwood Wash magma chamber was compositionally varied as shown by mineral and juvenile clast compositions. Whole-rock compositional variations are likely due to the variation of mineral proportions induced by shear in the magma chamber. Mineral compositions and experimental phase relationships show the pre-eruption magma crystallized at 800°C, 2.5 kb under water-undersaturated but oxidized conditions (delta QFM = 2.1). The majority of plagioclase and amphibole grains exhibit small-scale oscillatory zonation; where systematic compositional zonation exists, normal and reverse zonation are equally present. Cathodoluminescence of quartz reveals typically normally zoned phenocrysts with late resorption, considered to be the result of eruptive decompression. Many of the characteristics used to identify the rejuvenation of a near-solidus mush for the Fish Canyon Tuff are not present in the Cottonwood Wash Tuff [i.e., reversely zoned hornblende or plagioclase, partially remelted mineral aggregates, evidence of fluid saturation, resorption textures not related to decompression, rapakivi mantles, and hybrid andesite inclusions.] The Cottonwood Wash magma system did not undergo

  17. Celebration of DOE's 35th Anniversary and the Secretary of Energy's Honor Awards, Keynote Address: Energy Secretary, Dr. Steven Chu

    ScienceCinema

    Chu, Steven (U.S. Energy Secretary)

    2012-10-18

    Dr. Steven Chu gives a keynote address marking the thirty-fifth anniversary of the Department of Energy (DOE). He highlights outstanding achievements of the Department and its scientists. Several of the Department's many Nobel Prize winners over the years are mentioned.

  18. Professional Development in Early Childhood Intervention: Where We Stand on the Silver Anniversary of PL 99-457

    ERIC Educational Resources Information Center

    Snyder, Patricia; Hemmeter, Mary Louise; McLaughlin, Tara

    2011-01-01

    We describe historical foundations of professional development (PD) in early childhood intervention (ECI) and where we stand on the silver anniversary of PL 99-457. To advance its scientific basis, we assert that it is important to define what is meant by PD; identify structural and process features of PD hypothesized to be effective for…

  19. 77 FR 21893 - Safety Zone; International Bridge 50th Anniversary Celebration Fireworks, St Mary's River, U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; International Bridge 50th Anniversary... Federal Register (73 FR 3316). Public Meeting We do not now plan to hold a public meeting, but you may.... 165.T09-0200 to read as follows: Sec. 165.T09-0200 Safety Zone International Bridge 50th...

  20. 77 FR 33094 - Safety Zone; International Bridge 50th Anniversary Celebration Fireworks, St. Mary's River, U.S...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; International Bridge 50th Anniversary..., Sault Sainte Marie, MI; in the Federal Register (77 FR 21893). We received 1 public submission... Locks, Sault Sainte Marie, MI; in the Federal Register (76 FR 22064). We received 1 public...

  1. Symposium--Perspectives on Motivation for Second Language Learning on the 50th Anniversary of Gardner & Lambert (1959)

    ERIC Educational Resources Information Center

    MacIntyre, Peter

    2010-01-01

    With the 50th anniversary of Robert C. Gardner and Wallace Lambert's seminal paper "Motivational variables in second language acquisition" (Gardner & Lambert 1959), we paused to reflect on the contributions the work has inspired and the state of the art in the study of motivation research.

  2. Risk Communication and Public Education in Edmonton, Alberta, Canada on the 10th Anniversary of the "Black Friday" Tornado

    ERIC Educational Resources Information Center

    Blanchard-Boehm, R. Denise; Cook, M. Jeffrey

    2004-01-01

    In July 1997, on the 10th anniversary of the great "Black Friday" Tornado, city officials of Edmonton, the print and broadcast media, agencies dealing in emergency management, and the national weather organisation recounted stories of the 1987, F5 tornado that struck Edmonton on a holiday weekend. The information campaign also presented…

  3. U.S. Commission on Civil Rights' 40th Anniversary: The Road Ahead for Civil Rights. A Civil Rights Symposium.

    ERIC Educational Resources Information Center

    Civil Rights Journal, 1997

    1997-01-01

    This special theme issue of the newly titled "Civil Rights Journal" (previously titled "Perspectives"), commemorates the 40th anniversary of the U.S. Commission on Civil Rights by presenting a written symposium that offers a wide range of perspectives on civil rights realities and the future of civil rights. Three context-setting articles…

  4. Comparison of efficacy of chemical peeling with 25% trichloroacetic acid and 0.1% retinoic acid for facial rejuvenation

    PubMed Central

    Gurel, Mehmet Salih; Gungor, Sule; Tekeli, Omur; Canat, Dilek

    2016-01-01

    Introduction Skin aging is a problem which negatively affects the psyche of the person, social relations, as well as work life and health and which compels the patients to find appropriate treatment methods. Numerous treatment methods have been developed in order to delay aging and to reduce the aging effects in addition to having a younger, healthier and more beautiful facial appearance. Aim To compare the efficiency, cosmetic results and possible adverse effects of the peeling treatment with 25% trichloroacetic acid (TCA) and 0.1% retinoic acid for facial rejuvenation in patients presenting with skin aging. Material and methods Fifty female patients in total presenting with medium and advanced degree skin aging were subject to this study. Two separate treatment groups were formed; the first group underwent chemical skin treatment with 25% TCA while the other group was applied with 0.1% retinoic acid treatment. Following the 4 months’ treatment the patients were controlled three times in total for post lesional hypopigmentation, hyperpigmentation, scars, skin irritation and other possible changes per month. The pretreatment and first follow-up visit, and final control images were comparatively evaluated by three observers via specific software. Results The healing rates of the group subject to retinoic acid were statistically higher (p < 0.05) compared to patients in the TCA group in the final follow-up visit following the treatment according to the first and second observers. On the other hand, according to the third observer, patients applied with retinoic acid presented with higher healing rates compared to those treated with TCA, however; this rate was not statistically significant (p > 0.05). The frequency of TCA- and retinoic acid-associated adverse effects was similar in both groups (p > 0.05). As a result of both treatments, a reduction in the quality of life scores as well as a pronounced recovery (p = 0.001) in the quality of life of those patients

  5. Juan Fernández Ridge (Nazca Plate): petrology and thermochronology of a rejuvenated hot spot trail

    NASA Astrophysics Data System (ADS)

    Reyes, J.; Lara, L. E.

    2012-04-01

    The Juan Fernández Ridge on the oceanic Nazca plate is thought to be a classic hot spot trail because of the apparent westward rejuvenation of the eruptive ages. However, geochronological data is still scarce and there are a few constrains to support this hypothesis like the ca. 9 Ma Ar-Ar age of the O'Higgins seamount (115 km from the Chile-Perú trench), some published K-Ar ages of ca. 3-4 Ma in Robinson Crusoe island (580 km from the trench) and ca. 1 Ma in Alejandro Selkirk (180 km further west). New reconnaissance K-Ar ages and specially the ongoing Ar-Ar dating effort in Robinson Crusoe define a ca. 1-4 Ma time span, which partially overlap with the age of Alejandro Selkirk, breaking the expected age progression given that the Nazca plate moves eastwards at ca. 6-8 cm/yr. In addition, new geological mapping shows a sharp unconformity between the older (ca. 4 Ma), strongly altered sequences and the more recent (ca. 1 Ma), post-erosional volcanic piles, where the proximal facies are still preserved. Petrological evidence also supports this evolution pattern. In fact, the partially altered older sequence is tholeiitic (Ba/Yb=12.70; La/Yb=8.12; Ba/Y=6.51; Ba/Zr=0.89). The shield stage (ca. 1-3 Ma) is transicional from tholeiitic to alkaline (Ba/Yb=18.07-8.32; La/Yb=4.59-9.84; Ba/Y=4.24-8.18; Ba/Zr=0.73-1.09) and the younger (ca. 1 Ma) is mostly alkaline (Ba/Yb=38.15; La/Yb=15.66; Ba/Y=20.27; Ba/Zr=2.31). A fixed deep-mantle plume origin for Pacific hot spots has been widely debated and concurrent phenomena arose as a possible explanation for non-linear age progressions and/or long-lived volcanic activity. In fact, intraplate regional tectonics, plume displacement, and mantle heterogeneities could be the main factor of the ridge architecture or the mask for a first-order linear trend. An ongoing mapping and dating effort is aimed to understand the evolution of the Juan Fernández Ridge, testing the main hypothesis. This research is supported by FONDECYT Project

  6. "Quitting smoking rejuvenates the skin": results of a pilot project on smoking cessation conducted in Milan, Italy.

    PubMed

    Serri, Riccarda; Romano, Maria Concetta; Sparavigna, Adele

    2010-01-01

    This study reports the results obtained during the "Quitting Smoking Rejuvenates the Skin" campaign, a pilot project in favor of the fight against nicotine addiction in women promoted by the Municipality of Milan jointly with other organizations. The initiative allowed researchers to evaluate the benefits on the skin obtained by cessation of smoking in a sample of 64 Caucasian women who smoked and who, in the period between February 2007 and November 2007, were followed by a team of dermatologists, psychologists, and nutritionists. During the dermatologic program, clinical and instrumental evaluations were made at the beginning of the study and at 3, 6, and 9 months. The state of skin aging was evaluated visually by giving a clinical score to each sign of skin aging (lines, vascular and pigmentation state, elasticity, brightness, texture of the skin). These signs were then correlated using a particular "spider web" graph called Spiderming, the result of Derming research that allows the monitoring of results obtained over time. Taking into account that a wider area of the graph coincides with more advanced skin aging, the graph of mean values observed in the study patients narrowed as time went by, reaching certain statistically significant values in as little as 6 months of observation. The patients' biological skin age was also calculated so as to better quantify the benefits they obtained by giving up smoking. It was possible to measure the biological age of the skin using noninvasive instrumental measurements of parameters such as skin smoothness, brightness, coloring, and elasticity. A complex mathematic algorithm processed the results obtained for each patient and, on this basis, calculated the biological age of the patient's skin. At the end of the program, an average reduction of about 13 years in the biological age of the patients' skin was found, while, at the beginning of the study, patients had presented with an average biological age of 9 years older

  7. Aging, rejuvenation, and memory effects in short-range Ising spin glass: Cu_0.5Co_0.5Cl_2-FeCl3 GBIC

    NASA Astrophysics Data System (ADS)

    Suzuki, M.; Suzuki, I. S.

    2004-03-01

    Cu_0.5Co_0.5Cl_2-FeCl3 GBIC undergoes a spin glass (SG) transition at Tg (= 3.92 ± 0.11 K). The system shows a dynamic behavior that has some similarities and some significant differences compared to a 3D Ising SG.^1 Here we report on non-equilibrium aging dynamics which has been studied using zero-field cooled (ZFC) magnetization and low frequency AC magnetic susceptibility.^2 The time dependence of the relaxation rate S(t) = (1/H)dM_ZFC/dln t for the ZFC magnetization after the ZFC aging protocol, shows a peak at a characteristic time t_cr near a wait time t_w, corresponding to a crossover from quasi equilibrium dynamics to non-equilibrium. The time t_cr strongly depends on t_w, temperature, magnetic field, and the temperature shift. The rejuvenation effect is observed in both i^' and i^'' under the T-shift and H-shift procedures. The memory of the specific spin configurations imprinted during the ZFC aging protocol can be recalled when the system is re-heated at a constant heating rate. The aging, rejuvenation, and memory effects are discussed in terms of the scaling concepts derived from numerical studies on 3D Edwards-Anderson spin glass model. 1. I.S. Suzuki and M. Suzuki, Phys. Rev. B 68, 094424 (2003) 2. M. Suzuki and I.S. Suzuki, cond-mat/0308285

  8. The Efficacy and Safety of Fractional CO2 Laser Combined with Topical Type A Botulinum Toxin for Facial Rejuvenation: A Randomized Controlled Split-Face Study

    PubMed Central

    Zhu, Jie; Ji, Xi; Li, Min; Chen, Xiao-e; Liu, Juan; Zhang, Jia-an; Luo, Dan; Zhou, Bing-rong

    2016-01-01

    Objective. We evaluated synergistic efficacy and safety of combined topical application of Botulinum Toxin Type A (BTX-A) with fractional CO2 laser for facial rejuvenation. Methods. Twenty female subjects were included for this split-face comparative study. One side of each subject's cheek was treated with fractional CO2 plus saline solution, and the other side was treated with fractional CO2 laser plus topical application of BTX-A. Patients received one session of treatment and evaluations were done at baseline, one, four, and twelve weeks after treatment. The outcome assessments included subjective satisfaction scale; blinded clinical assessment; and the biophysical parameters of roughness, elasticity, skin hydration, transepidermal water loss (TEWL), and the erythema and melanin index. Results. BTX-A combined with fractional CO2 laser sides showed higher physician's global assessment score, subject satisfaction score, roughness, skin hydration, and skin elasticity compared to that of fractional CO2 plus saline solution side at 12 weeks after treatment. TEWL and erythema and melanin index showed no significant differences between two sides at baseline, one, four, and twelve weeks after treatment. Conclusion. Topical application of BTX-A could enhance the rejuvenation effect of fractional CO2 laser. PMID:26998485

  9. A novel method of facial rejuvenation using a 2940-nm erbium:YAG laser with spatially modulated ablation: a pilot study.

    PubMed

    Trelles, M A; Khomchenko, V; Alcolea, J M; Martínez-Carpio, P A

    2016-09-01

    The objective of this study was to determine the efficacy and safety of a novel method of facial rejuvenation using a 2940-nm erbium:YAG laser with Spatially Modulated Ablation™. A pilot study was performed in 16 women with moderate to severe signs of facial aging relative to chronological age, who underwent two treatment sessions with an Er:YAG laser coupled to the RecoSMA™ technology (Linline, Minsk, Belarus). The whole face was treated in all patients. Clinical efficacy, tolerance, adverse effects, complications, and histological changes due to the treatment were evaluated. Clinical photographs and biopsies were taken before treatment and 3 months after the second treatment session. All patients completed the study and presented no significant complications. Histological changes in the epidermis and dermis as a result of treatment were found. Fine lines, wrinkles, and overall facial aging improved significantly (p < 0.0001). The mean reduction of fine lines and wrinkles was 59 % (r = 40-75 %). The mean improvement of overall facial aging was 74 % (r = 55-90 %). After showing the patients the comparative photographs before and after treatment, 75 % of women stated that they were satisfied or very satisfied and would recommend the treatment. Preliminary results show an excellent safety/efficacy profile for this novel technology, which, based on observed results, can be considered to have advantages over other methods of facial rejuvenation with lasers. PMID:27371450

  10. PREFACE: 25th IUPAP Conference on Computational Physics (CCP2013)

    NASA Astrophysics Data System (ADS)

    Shchur, Lev N.; Barash, Lev Yu

    2014-05-01

    Participants of the XXV IUPAP Conference on Computational physics came to Moscow at the end of the August during a hot period. It was not a hot period because of the summer; in fact, the weather was quite comfortable. It was a hot period for the atmosphere amidst scientific society in Russia, especially for scientists working for the Russian Academy of Sciences. Four years ago, the C20 IUPAP Commission on Computational Physics and Computational Physics Group of the European Physical Society chose Moscow for several reasons. The first reason was connected to the high level and deep traditions of computational physics in Russia. It is known from experience at the former CCP conferences that native participants contribute about half of the presentations which form the solid scientific background of the conference, and the good level of domestic science makes the conference interesting and successful. The second reason was due to the fact that for the last twenty years there were not many IUPAP conferences in Russia, and it was a time to open more places for information exchange and intensify scientific collaboration. Thirdly, it was common opinion four years ago that the situation in Russia had become stable enough after the transition to a modern society, which took almost a quarter of a century. The conference preface is continued in the pdf.

  11. Proceedings of the 25th Project Integration Meeting

    NASA Technical Reports Server (NTRS)

    Phillips, M.

    1985-01-01

    Topics addressed include: silicon sheet growth and characterization, silicon material, process development, high-efficiency cells, environmental isolation, engineering sciences, and reliability physics.

  12. The Orphan Nuclear Receptors at Their 25th Year Reunion

    PubMed Central

    Mullican, Shannon E.; DiSpirito, Joanna R.; Lazar, Mitchell A.

    2013-01-01

    The Nuclear Receptor superfamily includes many receptors identified based on their similarity to steroid hormone receptors but without a known ligand. The study of how these receptors are diversely regulated to interact with genomic regions to control a plethora of biological processes has provided critical insight into development, physiology and the molecular pathology of disease. Here we provide a compendium of these so-called Orphan Receptors, and focus on what has been learned about their modes of action, physiological functions, and therapeutic promise. PMID:24096517

  13. 25th ANNUAL NATIONAL CONFERENCE ON MANAGING ENVIRONMENTAL QUALITY SYSTEMS

    EPA Science Inventory

    The model results may help landscape ecologists produce indicators of surface water condition, such that unique combinations of these indicators can be used to infer the potential cause(s) and origin(s) of non-point pollution, which may lead to eutrophication in aquatic ecosystem...

  14. Proceedings, 25th international conference on ground control in mining

    SciTech Connect

    Peng, S.S.; Mark, C.; Finfinger, G.; Tadolini, S.; Wahab Khair, A.; Heasley, K.; Luo, Y.

    2006-07-01

    Topics covered include: computer and physical modelling; geology in ground control; geophysics in ground control; ground control; impoundments stability; longwall gateroad support design; longwall operations; longwall shields and standing supports; mine design; multiple-seam mining interactions; pillar and pillar extraction; roof bolting; roof bolting - resin; and subsidence. Most of the topics include a retrospective paper which summarises the progress of the subject field during the past 25 years.

  15. The 20th anniversary of EMBnet: 20 years of bioinformatics for the Life Sciences community

    PubMed Central

    D'Elia, Domenica; Gisel, Andreas; Eriksson, Nils-Einar; Kossida, Sophia; Mattila, Kimmo; Klucar, Lubos; Bongcam-Rudloff, Erik

    2009-01-01

    The EMBnet Conference 2008, focusing on 'Leading Applications and Technologies in Bioinformatics', was organized by the European Molecular Biology network (EMBnet) to celebrate its 20th anniversary. Since its foundation in 1988, EMBnet has been working to promote collaborative development of bioinformatics services and tools to serve the European community of molecular biology laboratories. This conference was the first meeting organized by the network that was open to the international scientific community outside EMBnet. The conference covered a broad range of research topics in bioinformatics with a main focus on new achievements and trends in emerging technologies supporting genomics, transcriptomics and proteomics analyses such as high-throughput sequencing and data managing, text and data-mining, ontologies and Grid technologies. Papers selected for publication, in this supplement to BMC Bioinformatics, cover a broad range of the topics treated, providing also an overview of the main bioinformatics research fields that the EMBnet community is involved in. PMID:19534734

  16. Anniversary of the discovery of sec mutants by Novick and Schekman.

    PubMed

    Spang, Anne

    2015-05-15

    This year marks the 35th anniversary of the isolation of 23 SEC genes. These genes all encode key regulators of the secretory pathway, and much of our knowledge of the secretory pathway is based on this initial discovery. The identification of the SEC genes is a result of combining genetics, biochemistry, and electron microscopy in a very clever way. Scientists have been busy ever since seeking to understand the function and regulation of these genes and to identify further key players in the process. Although most of the machinery acting along the secretory pathway is known and its function generally understood, knowledge of regulation of the pathway under various conditions is still scarce and will keep researchers busy for years to come. PMID:25972202

  17. The Jubilee of Medical Informatics in Bosnia and Herzegovina - 20 Years Anniversary

    PubMed Central

    Masic, Izet

    2009-01-01

    CONFLICT OF INTEREST: NONE DECLARED Last two years, the health informatics profession celebrated five jubilees in Bosnia and Herzegovina: thirty years from the introduction of the first automatic manipulation of data, twenty years from the establishment of Society for Medical Informatics BiH, fifteen years from the establishment of the Scientific and Professional Journal of the Society for Medical Informatics of Bosnia and Herzegovina „Acta Informatica Medica“, fifteen years on from the establishment of the first Cathedra for Medical Informatics on Biomedical Faculties in Bosnia and Herzegovina and five years on from the introduction of the method of “Distance learning” in medical curriculum. The author of this article are eager to mark the importance of the above mentioned Anniversaries in the development of Health informatics in Bosnia and Herzegovina and have attempted, very briefly, to present the most significant events and persons with essential roles throughout this period. PMID:24133382

  18. Proceedings of the X-15 First Flight 30th Anniversary Celebration

    NASA Technical Reports Server (NTRS)

    1991-01-01

    A technical symposium and pilot's panel discussion were held on June 8, 1989, to commemorate the 30th anniversary of the first free flight of the X-15 rocket-powered research aircraft. The symposium featured technical presentations by former key government and industry participants in the advocacy, design, manufacturing, and flight research program activities. The X-15's technical contributions to the X-30 are cited. The panel discussion participants included seven of the eight surviving research pilots who flew the X-15 experimental aircraft to world altitude and speed records which still stand. Pilot's remarks include descriptions of their most memorable X-15 flight experience. The report also includes a historical perspective of the X-15.

  19. Anniversary of the discovery of sec mutants by Novick and Schekman

    PubMed Central

    Spang, Anne

    2015-01-01

    This year marks the 35th anniversary of the isolation of 23 SEC genes. These genes all encode key regulators of the secretory pathway, and much of our knowledge of the secretory pathway is based on this initial discovery. The identification of the SEC genes is a result of combining genetics, biochemistry, and electron microscopy in a very clever way. Scientists have been busy ever since seeking to understand the function and regulation of these genes and to identify further key players in the process. Although most of the machinery acting along the secretory pathway is known and its function generally understood, knowledge of regulation of the pathway under various conditions is still scarce and will keep researchers busy for years to come. PMID:25972202

  20. 100th Anniversary of the Discovery of Helium in Natural Gas

    NASA Astrophysics Data System (ADS)

    Longsworth, Ralph Cady

    2006-04-01

    December 7, 2005 marks the 100th anniversary of the discovery of helium in natural gas by H. P. Cady and D. F. McFarland at the University of Kansas. The work was done in the Chemistry building, Bailey Hall, built in 1900 and designated as a National Historic Chemical Landmark in 2000. An early air liquefier was installed in 1903 and in the same year McFarland used the liquid air to analyze a sample of natural gas that wouldn't burn. He analyzed it as having 71% nitrogen plus the expected methane and residual gas that couldn't be condensed. It took two years to assemble the apparatus that Cady used to see the helium spectrum in the residual gas. This paper includes a discussion of the discoveries related to helium, personal insights into the life and contributions of H. P. Cady, and the evolution of its production.

  1. [Guardian of Mercy (the 70th anniversary of the Military Medical Museum)].

    PubMed

    Budko, A A

    2012-11-01

    The article is dedicated to the 70th anniversary of the Army Medical Museum, established in 1942. There are a lot of original materials and documents of medical support of the Russian army, introducing with the volume of medical care to the wounded and sick in the past among the exhibits located in St. Petersburg Museum. In recent years the museum created projects, gained popularity in Russia and abroad, which caused a lot of good reviews from professionals and audiences. Among them are "Anatomical Theatres", "Mercy Without Borders", "Together we are strong", "Between Life and Death", "Medicine Heights" and many others. The museum is well known in Russia and far beyond its borders as a custodian of historical traditions of Russian medicine, multidisciplinary research and educational institution, which is a unique cultural federal and international importance, according to the riches of museum collections unrivaled among medical museums of Russia and the world. PMID:23301294

  2. [Ivan Stepanovich Kolesnikov--"general of surgery" (the 110th anniversary of his birth)].

    PubMed

    Kotiv, B N; Karpovich, V V

    2011-12-01

    The article is devoted to the 110th anniversary of outstanding surgeon, scientist and educator, academician of the USSR Ivan Stepanovich Kolesnikov. During the Great Patriotic War--he was an army surgeon on the Central Front, and then--in Leningrad. As one of the pioneers of thoracic surgery, the first in the Soviet Union began to apply the resection of pulmonary tuberculosis, cancer, and acute and chronic suppurative diseases of the lung and pleura, reflecting the experience of more than 4,000 thousand operations in numerous monographs and published in 1960, major work, "Resection lights". On his initiative in 1961 was the first in the Soviet Union an independent chair of the thermal lesions, and in 1964--the country's first intensive care unit and intensive care. He published over 200 papers on topical issues of surgery, including 28 monographs. Under his leadership were trained 25 Ph.D. and 43 master's theses. PMID:22448502

  3. The centenary progress of molecular genetics. A 100th anniversary of T. H. Morgan's discoveries.

    PubMed

    Keros, Tomislav; Borovecki, Fran; Jemersić, Lorena; Konjević, Dean; Roić, Besi; Balatinec, Jelena

    2010-09-01

    A century ago, Thomas Hunt Morgan, the American scientist, studied the cytogenetic changes of drosophila and came to cytogenetic explanation of Mendel's basic laws of genetic heredity. These studies resulted in today's Mendel-Morgan chromosomal theory of heredity. On the occasion of the hundredth anniversary of this important discovery the authors have decided to give a review of the most significant achievements in the field of molecular genetics until the completion of the Human Genome Project. The most important points concerning the technology of DNA recombination and genetic engineering are also presented. The final section discusses the significance of previous achievements of molecular genetics in biomedicine and other related fields. There is also a tabular presentation of the sequence of the most important findings in the field of molecular genetics through time. PMID:20977123

  4. Cosmeceuticals for rejuvenation.

    PubMed

    Beer, Kenneth; Kellner, Erinn; Beer, Jacob

    2009-12-01

    Facial plastic surgeons are frequently called upon to enhance the appearance of their patients. Typically, this involves surgery of the face or neck. Increasingly, this may also require the use of injectables such as botulinum toxins, fillers, and volumizers. Lasers and light sources are used to enhance the appearance of the surface of the skin. Each of these modalities will help to improve the patient but are limited by the fact that they require the patient to be treated in the office. With the advent of effective topical agents, patients are increasingly able to improve their appearance with the use of prescription and nonprescription topical products. It is incumbent upon the facial plastic surgeon to have an understanding of these topical agents so that they can assist the patient in deciding what does and does not make sense. In addition, many cosmetic physicians will dispense these products in their office, and it behooves them to understand the various products available and what will likely be produced in the future. PMID:20024869

  5. PREFACE: 40th anniversary of the Japan Society of Fluid Mechanics 40th anniversary of the Japan Society of Fluid Mechanics

    NASA Astrophysics Data System (ADS)

    Aoki, Kazuo

    2009-12-01

    The Japan Society of Fluid Mechanics (JSFM) turned 40 years old in 2008. To celebrate the 40th anniversary, JSFM organized a one-day conference on 5 September 2008 at Kobe University Centennial Hall. The conference was composed of seven invited lectures: three of them were given by distinguished foreign researchers and four were given by relatively young but internationally active Japanese researchers. At the same time, JSFM planned to dedicate an issue of Fluid Dynamics Research (FDR) to the conference. This special issue, which contains six articles based on the lectures at the conference, is the fruition of the plan. The promising program of the conference and the fact that the second day of the Annual Meeting of JSFM was dedicated to this conference attracted a large audience (215 participants). The conference was indeed very successful, thanks to the outstanding lectures and active participation of the audience. I am sure that the articles in this special section, which cover several important areas in modern fluid dynamics, will also interest the readers of FDR. In particular, it will be a great pleasure to me if young researchers are stimulated and motivated by the articles. As the chair of the one-day conference, I would like to express my thanks to Prof. N D Katopodes, Prof. G J F van Heijst, Prof. S Zaleski, Prof. G Kawahara, Prof. S Takagi and Prof. Y Tsuji for their contributions to this special section. Taking this opportunity, I would also like to thank Prof. S Kida (President of JSFM in 2008), Prof. M Funakoshi (Editor-in-Chief of FDR) and the members of the organizing committee of the conference for their continued support and cooperation.

  6. 3 CFR 8533 - Proclamation 8533 of June 10, 2010. 90th Anniversary of the Department of Labor Women’s Bureau, 2010

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 3 The President 1 2011-01-01 2011-01-01 false Proclamation 8533 of June 10, 2010. 90th Anniversary of the Department of Labor Womenâs Bureau, 2010 8533 Proclamation 8533 Presidential Documents Proclamations Proclamation 8533 of June 10, 2010 Proc. 8533 90th Anniversary of the Department of Labor Women’s Bureau, 2010By the President of the...

  7. Exhumation history of the West Kunlun Mountains, northwestern Tibet: Evidence for a long-lived, rejuvenated orogen

    NASA Astrophysics Data System (ADS)

    Cao, Kai; Wang, Guo-Can; Bernet, Matthias; van der Beek, Peter; Zhang, Ke-Xin

    2015-12-01

    related to initial thrusting of the Tiklik fault and reactivation of the Tam Karaul thrust. Thrusting together with upper crustal shortening in the mountain front indicates basinward expansion of the West Kunlun orogen at this time. This episode of exhumation and uplift, associated with magmatism across western Tibet, is compatible with a double-sided lithospheric wedge model, primarily driven by breakoff of the Indian crustal slab. Accelerated exhumation of the mountain front at a rate of ∼1.1 km/Myr since ∼15 Ma supports active compressional deformation at the margins of the northwestern Tibetan Plateau. We thus propose that the West Kunlun Mountains are a long-lived topographic unit, dating back to Triassic-Early Jurassic times, and have experienced Middle-Late Mesozoic to Early Cenozoic rejuvenation and Late Oligocene-Miocene expansion.

  8. [Branch N 1 of the Vishhnevsky central military clinical hospital N 3 celebrates the 70th anniversary].

    PubMed

    Esipov, A V; Meshkov, A V; Galik, V P; Musailov, V A

    2016-04-01

    On May 2016 the 114th Central aircraft hospital of fighters of air defense troop celebrates the 70th anniversary. Since the establishment of the hospital soldiers took an active part in medical support of the Soviet and later the Russian Air Force. During its existence, the hospital repeatedly reorganized, is now a modern military medical institution, has qualified and specialized medical care to the wounded and sick. PMID:27416723

  9. Photobiomodulation of distinct lineages of human dermal fibroblasts: a rational approach towards the selection of effective light parameters for skin rejuvenation and wound healing

    NASA Astrophysics Data System (ADS)

    Mignon, Charles; Uzunbajakava, Natallia E.; Raafs, Bianca; Moolenaar, Mitchel; Botchkareva, Natalia V.; Tobin, Desmond J.

    2016-03-01

    Distinct lineages of human dermal fibroblasts play complementary roles in skin rejuvenation and wound healing, which makes them a target of phototherapy. However, knowledge about differential responses of specific cell lineages to different light parameters and moreover the actual molecular targets remain to be unravelled. The goal of this study was to investigate the impact of a range of parameters of light on the metabolic activity, collagen production, and cell migration of distinct lineages of human dermal fibroblasts. A rational approach was used to identify parameters with high therapeutic potential. Fibroblasts exhibited both inhibitory and cytotoxic change when exposed to a high dose of blue and cyan light in tissue culture medium containing photo-reactive species, but were stimulated by high dose red and near infrared light. Cytotoxic effects were eliminated by refreshing the medium after light exposure by removing potential ROS formed by extracellular photo-reactive species. Importantly, distinct lineages of fibroblasts demonstrated opposite responses to low dose blue light treatment when refreshing the medium after exposure. Low dose blue light treatment also significantly increased collagen production by papillary fibroblasts; high dose significantly retarded closure of the scratch wound without signs of cytotoxicity, and this is likely to have involved effects on both cell migration and proliferation. We recommend careful selection of fibroblast subpopulations and their culture conditions, a systematic approach in choosing and translating treatment parameters, and pursuit of fundamental research on identification of photoreceptors and triggered molecular pathways, while seeking effective parameters to address different stages of skin rejuvenation and wound healing.

  10. N-terminal-mediated oligomerization of DnaA drives the occupancy-dependent rejuvenation of the protein on the membrane

    PubMed Central

    Aranovich, Alexander; Braier-Marcovitz, Shani; Ansbacher, Esti; Granek, Rony; Parola, Abraham H.; Fishov, Itzhak

    2015-01-01

    DnaA, the initiator of chromosome replication in most known eubacteria species, is activated once per cell division cycle. Its overall activity cycle is driven by ATP hydrolysis and ADP–ATP exchange. The latter can be promoted by binding to specific sequences on the chromosome and/or to acidic phospholipids in the membrane. We have previously shown that the transition into an active form (rejuvenation) is strongly co-operative with respect to DnaA membrane occupancy. Only at low membrane occupancy is DnaA reactivation efficiently catalysed by the acidic phospholipids. The present study was aimed at unravelling the molecular mechanism underlying the occupancy-dependent DnaA rejuvenation. We found that truncation of the DnaA N-terminal completely abolishes the co-operative transformation between the high and low occupancy states (I and II respectively) without affecting the membrane binding. The environmentally sensitive fluorophore specifically attached to the N-terminal cysteines of DnaA reported on occupancy-correlated changes in its vicinity. Cross-linking of DnaA with a short homobifunctional reagent revealed that state II of the protein on the membrane corresponds to a distinct oligomeric form of DnaA. The kinetic transition of DnaA on the membrane surface is described in the present study by a generalized 2D condensation phase transition model, confirming the existence of two states of DnaA on the membrane and pointing to the possibility that membrane protein density serves as an on-off switch in vivo. We conclude that the DnaA conformation attained at low surface density drives its N-terminal-mediated oligomerization, which is presumably a pre-requisite for facilitated nt exchange. PMID:26272946

  11. IPL irradiation rejuvenates skin collagen via the bidirectional regulation of MMP-1 and TGF-β1 mediated by MAPKs in fibroblasts.

    PubMed

    Huang, Jinhua; Luo, Xiang; Lu, Jianyun; Chen, Jing; Zuo, Chengxin; Xiang, Yaping; Yang, Shengbo; Tan, Lina; Kang, Jian; Bi, Zhigang

    2011-05-01

    The efficacy of intense pulsed light (IPL) in remodeling the extracellular matrix of aged skin had been proven by an increasing number of clinical trials. However, because of the lack of research about the underlying molecular and signaling mechanisms, its efficiency had not been accepted universally. A potential mechanism of IPL rejuvenation effects is due to its different effects on diverse cytokines, the impact of IPL on them may determine the phenotype and prognosis of the aged skin. We designed this study to evaluate the impact of IPL on the secretion of matrix metalloproteinase-1 (MMP-1), transforming growth factor-β1 (TGF-β1), and the mitogen-activated protein kinase (MAPK) signaling pathway in human skin fibroblasts, and tried to study the respective functions of MAPKs as mediators of the MMP-1, TGF-β1 secretion. Results showed that the MMP-1 secretion was only enhanced by IPL at 10 J/cm(2); while the TGF-β1 secretion was inhibited by IPL when the fluence was below 36 J/cm(2), but enhanced at 72 J/cm(2). Meanwhile, ERK inhibitor PD98059 decreased MMP-1 secretion, but did not show a significant influence on TGF-β1; JNK inhibitor SP600125 increased the secretion of MMP-1 and decreased the TGF-β1 secretion; P38 inhibitor SB203580 had no significant influence on MMP-1 but increased the secretion of TGF-β1. Our findings indicated that the bidirectional influence of IPL on the secretion of MMP-1 and TGF-β1 is a potential mechanism of its skin rejuvenation effect; and the secretion of these two cytokines can be mediated by MAPKs. PMID:21161310

  12. Human growth factor and cytokine skin cream for facial skin rejuvenation as assessed by 3D in vivo optical skin imaging.

    PubMed

    Gold, Michael H; Goldman, Mitchel P; Biron, Julie

    2007-10-01

    Growth factors, in addition to their crucial role in cutaneous wound healing, are also beneficial for skin rejuvenation. Due to their multifunctional activities such as promoting skin cell proliferation and stimulating collagen formation, growth factors may participate in skin rejuvenation at various levels. The present placebo-controlled study aimed to further investigate the antiaging effects of a novel skin cream containing a mixture of human growth factors and cytokines, which was obtained through a biotechnology process using cultured human fetal fibroblasts. Aside from clinical assessment of skin wrinkles, the skin surface topography was analyzed by 3D in vivo optical skin imaging using the Phaseshift Rapid in vivo Measurement of Skin (PRIMOS) device. This device allows fast, contact-free, and direct measurement of the skin surface topography in vivo at high resolution. This technique is quantitative and more reliable than a visual assessment of wrinkles using a scoring system, which is subjective and strongly dependent on investigator and assessment conditions. Using the PRIMOS device, which is also regarded as a more accurate method than the commonly used silicon replica technique, skin surface roughness was shown to significantly decrease between 10% and 18% depending on the roughness parameter after 2 months of twice-daily application of the human growth factor and cytokine cream. This was compared to treatment with the placebo formulation resulting in an approximate 10% decrease of 2 roughness parameters, whereas the remaining parameters remained unchanged. We found that topical application of growth factors and cytokines are beneficial in reducing signs of skin aging. PMID:17966179

  13. The prominent absence of Alfred Russel Wallace at the Darwin anniversaries in Germany in 1909, 1959 and 2009.

    PubMed

    Hossfeld, Uwe; Olsson, Lennart

    2013-12-01

    It is well known that the contribution of Alfred Russell Wallace (1823-1913) to the development of the "Darwinian" principle of natural selection has often been neglected. Here we focus on how the three anniversaries to celebrate the origin of the Darwin-Wallace theory in Germany in 1909, in 1959 in the divided country, as well as in 2009, have represented Charles Robert Darwin's and Alfred Russell Wallace's contributions. We have analyzed books and proceedings volumes related to these anniversaries, and the main result is that Wallace was almost always ignored, or only mentioned in passing. In 1909, Ernst Haeckel gave a talk in Jena, later published under the title The worldview of Darwin and Lamarck (Das Weltbild von Darwin und Lamarck), but not as the Darwin-Wallace concept. Haeckel mentions Wallace only once. In two important proceedings volumes from the 1959 anniversaries, Wallace was ignored. The only fair treatment of Wallace is given in another book, a collection of documents edited by Gerhard Heberer, for which the author selected nine key documents and reprinted excerpts (1959). Three of them were articles by Wallace, including the Sarawak- and Ternate-papers of 1855 and 1858, respectively. An analysis of the dominant themes during the celebrations of 2009 shows that none of the six topics had much to do with Wallace and his work. Thus, the tendency to exclude Alfred Russell Wallace is an international phenomenon, and largely attributable to the "Darwin industry". PMID:23975642

  14. EDITORIAL: 'Best article' prize for the 5th anniversary of Environmental Research Letters 'Best article' prize for the 5th anniversary of Environmental Research Letters

    NASA Astrophysics Data System (ADS)

    Kammen, Dan; Wright, Guillaume

    2011-12-01

    To celebrate the 5th anniversary of Environmental Research Letters (ERL) the publishers of the journal, IOP Publishing, have awarded a prize for the five best articles published in ERL since the journal began in 2006. The procedure for deciding the winning articles was as thorough as possible to ensure that the most outstanding articles would win the prize. A shortlist of 25 nominated research articles, five for each year since ERL was launched, which were chosen based on a range of criteria including novelty, scientific impact, readership, broad appeal and wider media coverage, was selected. The ERL Editorial Board then assessed and rated these 25 articles in order to choose a winning article for each year. We would like to announce that the following articles have been awarded ERL's 5th anniversary best article prize: 2006/7 The Bodélé depression: a single spot in the Sahara that provides most of the mineral dust to the Amazon forest Ilan Koren, Yoram J Kaufman, Richard Washington, Martin C Todd, Yinon Rudich, J Vanderlei Martins and Daniel Rosenfeld 2006 Environ. Res. Lett. 1 014005 2008 Causes and impacts of the 2005 Amazon drought Ning Zeng, Jin-Ho Yoon, Jose A Marengo, Ajit Subramaniam, Carlos A Nobre, Annarita Mariotti and J David Neelin 2008 Environ. Res. Lett. 3 014002 2009 How difficult is it to recover from dangerous levels of global warming? J A Lowe, C Huntingford, S C B Raper, C D Jones, S K Liddicoat and L K Gohar 2009 Environ. Res. Lett. 4 014012 2010 Is physical water scarcity a new phenomenon? Global assessment of water shortage over the last two millennia Matti Kummu, Philip J Ward, Hans de Moel and Olli Varis 2010 Environ. Res. Lett. 5 034006 2011 Implications of urban structure on carbon consumption in metropolitan areas Jukka Heinonen and Seppo Junnila 2011 Environ. Res. Lett. 6 014018 Our congratulations go to these authors. In recognition of their outstanding work, we are delighted to offer all of the authors of the winning articles free

  15. EDITORIAL: 'Best article' prize for the 5th anniversary of Environmental Research Letters 'Best article' prize for the 5th anniversary of Environmental Research Letters

    NASA Astrophysics Data System (ADS)

    Kammen, Dan; Wright, Guillaume

    2011-12-01

    To celebrate the 5th anniversary of Environmental Research Letters (ERL) the publishers of the journal, IOP Publishing, have awarded a prize for the five best articles published in ERL since the journal began in 2006. The procedure for deciding the winning articles was as thorough as possible to ensure that the most outstanding articles would win the prize. A shortlist of 25 nominated research articles, five for each year since ERL was launched, which were chosen based on a range of criteria including novelty, scientific impact, readership, broad appeal and wider media coverage, was selected. The ERL Editorial Board then assessed and rated these 25 articles in order to choose a winning article for each year. We would like to announce that the following articles have been awarded ERL's 5th anniversary best article prize: 2006/7 The Bodélé depression: a single spot in the Sahara that provides most of the mineral dust to the Amazon forest Ilan Koren, Yoram J Kaufman, Richard Washington, Martin C Todd, Yinon Rudich, J Vanderlei Martins and Daniel Rosenfeld 2006 Environ. Res. Lett. 1 014005 2008 Causes and impacts of the 2005 Amazon drought Ning Zeng, Jin-Ho Yoon, Jose A Marengo, Ajit Subramaniam, Carlos A Nobre, Annarita Mariotti and J David Neelin 2008 Environ. Res. Lett. 3 014002 2009 How difficult is it to recover from dangerous levels of global warming? J A Lowe, C Huntingford, S C B Raper, C D Jones, S K Liddicoat and L K Gohar 2009 Environ. Res. Lett. 4 014012 2010 Is physical water scarcity a new phenomenon? Global assessment of water shortage over the last two millennia Matti Kummu, Philip J Ward, Hans de Moel and Olli Varis 2010 Environ. Res. Lett. 5 034006 2011 Implications of urban structure on carbon consumption in metropolitan areas Jukka Heinonen and Seppo Junnila 2011 Environ. Res. Lett. 6 014018 Our congratulations go to these authors. In recognition of their outstanding work, we are delighted to offer all of the authors of the winning articles free

  16. Intense Pulsed Neutron Source: Progress report 1991--1996. 15. Anniversary edition -- Volume 2

    SciTech Connect

    1996-05-01

    The 15th Anniversary Edition of the IPNS Progress Report is being published in recognition of the Intense Pulsed Neutron Source`s first 15 years of successful operation as a user facility. To emphasize the importance of this milestone, the author shave made the design and organization of the report significantly different from previous IPNS Progress Reports. This report consists of two volumes. For Volume 1, authors were asked to prepare articles that highlighted recent scientific accomplishments at IPNS, from 1991 to present; to focus on and illustrate the scientific advances achieved through the unique capabilities of neutron studies performed by IPNS users; to report on specific activities or results from an instrument; or to focus on a body of work encompassing different neutron-scattering techniques. Articles were also included on the accelerator system, instrumentation, computing, target, and moderators. A list of published and ``in press` articles in journals, books, and conference proceedings, resulting from work done at IPNS since 1991, was compiled. This list is arranged alphabetically according to first author. Publication references in the articles are listed by last name of first author and year of publication. The IPNS experimental reports received since 1991 are compiled in Volume 2. Experimental reports referenced in the articles are listed by last name of first author, instrument designation, and experiment number.

  17. 50th Year Anniversary of Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University.

    PubMed

    Lertakyamanee, Jariya

    2016-05-01

    Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, has started to be a formal anesthesia division, divided from division of Surgery in 1965; hence our 50th year anniversary in 2015. Research is now a priority and mandatory mission, according to the vision of Mahidol University. Second mission is to teach and train, and we produce the highest number of states-of-the-art anesthesiologists and anesthetic nurses each year Curriculum and training are being continuously improved. From a small unit, now it is one of the largest departments and extends the service, our third mission, to more than only in the operating theaters. We look after pre-anesthesia assessment, inside and outside operating room anesthesia, post-operative pain relief Intensive Care Unit, and chronic pain management. The number of patients and their diseases increase; so do the complexities of surgeries. There are tremendous changes in drugs and equipment. There is the fourth mission on administration, IT and resource management. And the fifth mission which is corporate social responsibility. However, we still believe that compassion, responsibility and integrity are most important. We have taught and tried to live by the teaching of HRH the King's Father. And these will contribute to our progress and shine in the next 50 years. PMID:27501620

  18. Intense Pulsed Neutron Source: Progress report 1991--1996. 15. Anniversary edition -- Volume 1

    SciTech Connect

    Marzec, B.

    1996-05-01

    The 15th Anniversary Edition of the IPNS Progress Report is being published in recognition of the Intense Pulsed Neutron Source`s first 15 years of successful operation as a user facility. To emphasize the importance of this milestone, the authors have made the design and organization of the report significantly different from previous IPNS Progress Reports. This report consists of two volumes. For Volume 1, authors were asked to prepare articles that highlighted recent scientific accomplishments at IPNS, from 1991 to present; to focus on and illustrate the scientific advances achieved through the unique capabilities of neutron studies performed by IPNS users; to report on specific activities or results from an instrument; or to focus on a body of work encompassing different neutron-scattering techniques. Articles were also included on the accelerator system, instrumentation, computing, target, and moderators. A list of published and ``in press` articles in journals, books, and conference proceedings, resulting from work done at IPNS since 1991, was compiled. This list is arranged alphabetically according to first author. Publication references in the articles are listed by last name of first author and year of publication. The IPNS experimental reports received since 1991 are compiled in Volume 2. Experimental reports referenced in the articles are listed by last name of first author, instrument designation, and experiment number.

  19. [150th birth anniversary of Izidor Brennsohn, Latvian historian of medicine and researcher of Lithuanian anthropology].

    PubMed

    Andriusis, Aurimas; Viksna, Arnis

    2004-01-01

    This publication is dedicated to the 150th birth anniversary of a famous German-writing Latvian physician, historian of medicine, and anthropologist of Jewish descent Izidor Brennsohn, and to his ties with Lithuania. I. Brennsohn's works on physicians and the development of health care in Kurland, Livland, and Estland laid the foundations for the contemporary historiography of medicine in Latvia and Estonia. To a certain extent, these works could also be viewed as a digest of the sources of Lithuanian history of medicine, especially in regard to the regions on the boarder with Latvia, as well as to various personalities. However, Brennsohn's most important link with Lithuania was his doctoral thesis "On Lithuanian anthropology" ("Zur Anthropologie der Litauer"), defended at Dorpat (Tartu) University in 1883. It was one of the first works dealing with Lithuanian ethnic anthropology as a whole. Although, material of thesis could not be used for wider generalizations, still, it is one of rare and valuable 19th century sources of Lithuanian anthropology. Brennsohn's legacy deserves greater attention from people researching medical history in Lithuania. PMID:15456980

  20. Celebrating the 50th anniversary of the American Academy of Psychoanalysis and Dynamic Psychiatry.

    PubMed

    Eckardt, Marianne Horney

    2006-01-01

    On the occasion of its 50 anniversary, the members of the American Academy of Psychoanalysis and Dynamic Psychiatry can look back with pride and be aware that this professional society has been true to its original goal and passionate mission. Thanks for this momentous accomplishment goes to its founding fathers and mothers, who were clear in their purpose and whose wisdom is manifest in the Academy's constitution. In the 1930s, the orthodoxy of the American Psychoanalytic Association created a ferment of rebellion in most of its institutes, which led to secessions, sister institutes, and a greater open-mindedness in institutes residing in Chicago, Washington, New Orleans, and Detroit. The quest for a new national forum that would be open to an exchange of new ideas began in 1951 and culminated in the formation of the American Academy of Psychoanalysis in 1956. The spirit of the Academy is highlighted by relating the successful struggle of communication among its members in a dream workshop that existed for six years. PMID:16548742

  1. Celebrating 25 Years: 1980-2005

    ERIC Educational Resources Information Center

    McLester, Susan; Poftak, Amy

    2005-01-01

    This article presents a brief history of Classroom Computer News magazine celebrating its 25th anniversary. The authors provide a brief description of each year's important activities and issues that can be remembered in its 25th anniversary. Among other things, during the year 1990, the magazine updates its name to Technology & Learning. The…

  2. A randomized, placebo-controlled, single-blinded, split-faced clinical trial evaluating the efficacy and safety of KLOX-001 gel formulation with KLOX light-emitting diode light on facial rejuvenation

    PubMed Central

    Nikolis, Andreas; Bernstein, Steven; Kinney, Brian; Scuderi, Nicolo; Rastogi, Shipra; Sampalis, John S

    2016-01-01

    Purpose Many treatment modalities exist to counteract the effects of cutaneous aging. Ablative methods have been the mainstay for nonsurgical facial rejuvenation. In recent years, nonablative techniques have been developed with the aim of achieving facial rejuvenation without epidermal damage. Light-emitting diode (LED) photorejuvenation is a novel nonablative technique that induces collagen synthesis through biophotomodulatory pathways. Materials and methods A single-center, randomized, single-blinded, placebo-controlled, split-faced clinical trial was designed. Thirty-two patients were enrolled for a 12-week study. Patients were randomized into one of four groups: Group A, treatment with KLOX-001 gel formulation and white LED (placebo) light; Group B, treatment with a placebo/base gel (no active chromophore) formulation and KLOX LED light; Group C, treatment with KLOX-001 gel formulation and KLOX LED light; and Group D, treatment with the standard skin rejuvenating treatment (0.1% retinol-based cream). Patients received treatment at weeks 0, 1, 2, and 3, and returned to the clinic at weeks 4, 8, and 12 for clinical assessments performed by an independent, blinded committee of physicians using subjective clinician assessment scales. Tolerability, adverse outcomes, and patient satisfaction were also assessed. Results Analysis demonstrated that the KLOX LED light with KLOX placebo/base gel and the KLOX LED light + KLOX-001 gel formulation groups were superior to standard of care and KLOX-001 gel formulation with placebo light on subjective clinical assessment and multiple wrinkle scales, with statistically significant results obtained for brow positioning, perioral wrinkling, and total wrinkle score. Conclusion The study results show that KLOX LED light with KLOX-001 gel formulation and KLOX LED light with KLOX placebo/base gel are effective, safe, well-tolerated, and painless treatment modalities for skin rejuvenation. PMID:27257391

  3. National Aeronautics and Space Administration Twenty-Fifth Anniversary, 1958-1983

    NASA Technical Reports Server (NTRS)

    1983-01-01

    This year marks a major milestone for the National Aeronautics and Space Administration: its silver anniversary. It seems appropriate, on this occasion, to sum up how NASA has responded to the legislative charter that established the agency. Among the responsibilities the Congress assigned NASA in the National Aeronautics and Space Act of 1958 were these: preservation of U.S. leadership in aerospace science and technology; cooperation with other nations in the peaceful application of technology; expansion of human knowledge of phenomena in the atmosphere and in space; pursuit of the practical benefits to be gained from aeronautical and space activities. There can be no doubt that NASA's quarter century of effort has preserved the nation's leadership role and strengthened its posture in aerospace science and technology. As for international cooperation. NASA has - since its inception - fostered the concept that the fruits of civil space research are to be shared with all mankind. The agency has provided technical assistance to scores of nations and has actively promoted cooperative ventures; indeed, virtually every major NASA space project today boasts some degree of foreign participation. In the last 25 years, man has teamed more about his planet, the near-Earth environment, and the universe than in all the prior years of history. NASA's space science program has spearheaded this great expansion of human knowledge. And, from the beginning, NASA has vigorously pursued the practical benefits that aerospace research offers. The agency pioneered in weather, communications and Earth resources survey satellites, the prime examples of space technology applied for Earth benefit, and it has built a broad base for expanding into new applications, some of which promise direct benefits of exceptional order. In aeronautical research, NASA has contributed in substantial degree to safer, better performing, more efficient, more environmentally acceptable aircraft.

  4. Soil-geographical and ecological tour in West-Russia: 20 years anniversary

    NASA Astrophysics Data System (ADS)

    Kuzyakov, Yakov

    2013-04-01

    Soil-geographical and agro-ecological tour in Russia celebrated in this summer its 20 years anniversary! More than 800 students, PhD students and researcher from Germany, Switzerland, Austria, Sweden and France participated at the tour since 1993. The majority of the participants were students studying soil science, geoecology, geography, agriculture and ecology. The tour is based on a classical Russian zonal approach: a cross-section of climatic zones starting from south taiga, through deciduous forest, forest steppe, steppe, dry steppe, to semi dessert and transition to the desert zone. In each zone the specifics of climate, vegetation, nutrient cycling, and of course soil genesis as well as soil use by forestry and agriculture are described. Half of the soil group units of WRB classification (2006) are presented on about 35 soil profile pits and are described with focus on pedogenic processes and soil forming factors. The following soil groups are described in details by horizons according to WRB soil classification (2006): Arenosols, Podzols, Albeluvisols Histosols, Gleysols, Luvisols, Phaeozems, Chernozems, Kastanozems, Calcisols, Vertisols, Leptosols, Fluvisols, Solonetzes, Solonchaks. In addition to natural conditions, large-scale experiments designing agricultural landscapes (stone steppe), biosphere reserves and conservation areas (Tula-Schneisen, Divnogor'je, Baskunchak), as well as collective agricultural farms (previously kolkhoz) are visited to evaluate the anthropogenic effects on ecosystems and especially on soils. The 2.5 weeks bus journey through many villages and small towns, visits of museums and historical monuments, introduction in the settlement development of different regions provide a broad presentation of Russian history, traditions, life style, and contemporary state. So, combination of very diverse educational part focused on soil and environmental conditions with anthropogenic impacts and local history as well as recent socioeconomic

  5. Testing the anniversary reaction: causal effects of bereavement in a nationwide follow-up study from Sweden.

    PubMed

    Rostila, Mikael; Saarela, Jan; Kawachi, Ichiro; Hjern, Anders

    2015-03-01

    Lingering grief associated with the death of a loved one has been hypothesized to precipitate acute health events among survivors on anniversary dates. We sought to study excess mortality risk in parents around the death date and birth date of a deceased child as an indication of a "bereavement effect". We conducted a population based follow-up study using Swedish registries including links between children and parents. All biological and Swedish-born parents who experienced the death of a minor child born were observed during the period 1973-2008 (n = 48,666). An increased mortality risk was found during the week of a child's death among mothers who lost a child aged 0-17 years (SMRR = 1.46, 95% CI 0.98-2.17). The association was stronger among mothers who lost a child aged 1-17 years (SMRR = 1.89, 95% CI 0.97-3.67) as compared to those who lost an infant (SMRR = 1.29, 95% CI 0.78-2.12). Cardiovascular diseases and suicides were overrepresented as causes of death in mothers who died around the anniversary. We found no significant increase in the mortality risk around the date of child's birth, nor any suggestion of excess mortality risk among fathers, but rather a depression of paternal death (SMRR = 0.60, 95% CI 0.34-1.03). Our study indicates an anniversary reaction among mothers who lost a young child. These results suggest that bereavement per se could have an effect on health and mortality which should be acknowledged by public health professionals working with bereaved people. PMID:25595319

  6. Tenth anniversary of CAS ONLINE service : What CAS services should be in the new era of chemical information

    NASA Astrophysics Data System (ADS)

    Kostakos, Charles N.

    Chemical Abstracts Service celebrated 10th anniversary of CAS online information service in 1990. A speech given on the occasion reviewed history of the CAS ONLINE, in relation to its most important benefits for scientists and engineers. The development of STN international, the network through which CAS ONLINE is accessible around the world, was also discussed in the speech. The CAS ONLINE now contains a wide variety of files relating to chemical field including CA file, Registry file. CA previews,. CASREACT, CIN. MARPAT, etc for supplying chemical information worldwide.

  7. [A country doctor: a proposal of an ethical approach in the 125th anniversary of Frank Kafka's birth].

    PubMed

    Alvarez-Díaz, Jorge Alberto

    2008-01-01

    Within the framework of the 125 anniversary of the birth of Franz Kafka we discuss his work as a patient affected by tuberculosis. This essay outlines a review of Kafka as a writer and explains the meaning of the term "Kafkaesque". We put forward a commentary on the ethics expressed in a short story entitled A country doctor. An interpretation of Kafka must involve the notion of responsibility, a theological concept that is then followed by the legal context. Finally, Kafka embraces an ethical approach expressed in his work. PMID:19112729

  8. [Georg Ernst Stahl (1659-1734)--on the 250th anniversary of his death 14 May 1984].

    PubMed

    Kaiser, W

    1984-08-01

    The 250th anniversary of Georg Ernst Stahl's death (1659-1734) is the occasion for remembering the remarkable work of this Halle professor in ordinary. In the history of medicine and natural sciences Georg Ernst Stahl is imbedded on the one hand by his psychodynamistic system and on the other hand by the foundation of the phlogiston chemistry. The enactment of the Prussian Medicinal Edict of 1725, which created new criteria for the organised public health of his time, took place during the time of his function as archiater in Berlin. PMID:6388168

  9. [ELIE METCHNIKOFF--THE FOUNDER OF LONGEVITY SCIENCE AND A FOUNDER OF MODERN MEDICINE: IN HONOR OF THE 170TH ANNIVERSARY].

    PubMed

    Stambler, I S

    2015-01-01

    The years 2015-2016 mark a double anniversary--the 170th anniversary of birth and the 100th anni- versary of death--of one of the greatest Russian scientists, a person that may be considered a founding figure of modern immunology, aging and longevity science--Elie Metchnikoff (May 15, 1845-July 15, 1916). At this time of the rapid aging of the world population and the rapid development of technologies that may ameliorate degenerative aging processes, Metchnikoff's pioneering contribution to the search for anti-aging and healthspan-extending means needs to be recalled and honored. PMID:26856081

  10. Wilbur and Orville Wright: A Bibliography Commemorating the One-Hundredth Anniversary of the First Powered Flight, December 17, 1903. Revised

    NASA Technical Reports Server (NTRS)

    Renstrom, Arthur G. (Compiler); Goldblatt, Roberta W.; Minkus, Carl; Berube, Karen L.; Launius, Roger (Technical Monitor)

    2002-01-01

    This annotated bibliography of material about Wilbur and Orville Wright and the first powered flight, commemorates the one hundredth anniversary of the event. This publication represents an updated version of the classic, "Wilbur and Orville Wright: A Bibliography Commemorating the Hundredth Anniversary of the Birth of Wilbur Wright, April 16, 1867" which was originally published in 1968. Aspects of the Wright brothers' lives covered include: their published writings, biographical references, airplanes used and flight records, airplane components, patents, court records, Wright companies and schools, the Wright-Smithsonian controversy, monuments and museums, memorials, medals and honors, memorabilia, art, poetry, music, motion pictures and juvenile publications. An index is included.

  11. Quantification of material loss from the neck piece taper junctions of a bimodular primary hip prosthesis. A retrieval study from 27 failed Rejuvenate bimodular hip arthroplasties.

    PubMed

    Buente, D; Huber, G; Bishop, N; Morlock, M

    2015-10-01

    The early failure and revision of bimodular primary total hip arthroplasty prostheses requires the identification of the risk factors for material loss and wear at the taper junctions through taper wear analysis. Deviations in taper geometries between revised and pristine modular neck tapers were determined using high resolution tactile measurements. A new algorithm was developed and validated to allow the quantitative analysis of material loss, complementing the standard visual inspection currently used. The algorithm was applied to a sample of 27 retrievals (in situ from 2.9 to 38.1 months) of the withdrawn Rejuvenate modular prosthesis. The mean wear volumes on the flat distal neck piece taper was 3.35 mm(3) (0.55 to 7.57), mainly occurring in a characteristic pattern in areas with high mechanical loading. Wear volume tended to increase with time to revision (r² = 0.423, p = 0.001). Implant and patient specific data (offset, stem size, patient's mass, age and body mass index) did not correlate with the amount of material loss observed (p > 0.078). Bilaterally revised implants showed higher amounts of combined total material loss and similar wear patterns on both sides. The consistent wear pattern found in this study has not been reported previously, suggesting that the device design and materials are associated with the failure of this prosthesis. PMID:26430009

  12. Bioactive reagents used in mesotherapy for skin rejuvenation in vivo induce diverse physiological processes in human skin fibroblasts in vitro- a pilot study.

    PubMed

    Jäger, Claudia; Brenner, Christiane; Habicht, Jüri; Wallich, Reinhard

    2012-01-01

    The promise of mesotherapy is maintenance and/or recovery of a youthful skin with a firm, bright and moisturized texture. Currently applied medications employ microinjections of hyaluronic acid, vitamins, minerals and amino acids into the superficial layer of the skin. However, the molecular and cellular processes underlying mesotherapy are still elusive. Here we analysed the effect of five distinct medication formulas on pivotal parameters involved in skin ageing, that is collagen expression, cell proliferation and morphological changes using normal human skin fibroblast cultures in vitro. Whereas in the presence of hyaluronic acid, NCTF135(®) and NCTF135HA(®) , cell proliferation was comparable to control cultures; however, with higher expression of collagen type-1, matrix metalloproteinase-1 and tissue inhibitor of matrix metalloproteinase-1, addition of Soluvit(®) N and Meso-BK led to apoptosis and/or necrosis of human fibroblasts. The data indicate that bioactive reagents currently applied for skin rejuvenation elicit strikingly divergent physiological processes in human skin fibroblast in vitro. PMID:22151394

  13. The 100th Anniversary of the Fall of Nakhla: The Subdivision of BM1913,25

    NASA Technical Reports Server (NTRS)

    McBridge, Kathleen M.; Righter, K.

    2011-01-01

    This year marks the 100th anniversary of the fall of Nakhla, a cumulate clinopyroxenite of martian origin that fell near Alexandria, Egypt in 1911. Multiple fragments of the meteorite were seen to fall over an area of 4.5 km in diameter. Approximately 40 stones were recovered with a combined weight of about 10 kg. Most of the larger specimens found their way to museums and meteorite collections in Cairo, Paris, Berlin, and the Smithsonian, to name a few. In 1998, the British Museum sent a 641g (BM1913,25), fully fusion crusted stone of Nakhla to the Johnson Space Center (JSC) for processing in the Antarctic Meteorite Lab in order to allocate samples to the scientific community. The stone was split in half in a dry nitrogen glove box. One half of the stone was sent back to the museum and the other half (346g) was used for sample allocations. From 1998-2001, 37 scientists requested 65 separate samples of Nakhla, including 2 thin sections This set of allocations was especially important in that all of the sample splits are from the same piece of Nakhla and it had a known history since it was acquired by the museum in 1913. With the multiple fragments of Nakhla, it is not known from what pieces the main bulk of research has been done, what variation may exist between all the pieces and to what contaminants the fragments may have been exposed, (i.e. water, solvents or cutting fluids, etc.). All of the allocations prepared at JSC were processed in a nitrogen cabinet using only stainless steel, aluminum, and Teflon tools and containers to reduce the chance of introducing any new contaminants. The focused effort to subdivide and distribute samples of Nakhla to the meteorite community resulted in enhanced under-standing of Nakhla and nakhlites in general: organic geochemistry, weathering, sulfur isotopes, radiometric age, and magmatic history. There are 13 Nakhlites that have been recovered to date: Nakhla, Layfayette, Governador Valdares, three from NW Africa, three from

  14. The Program for climate Model diagnosis and Intercomparison: 20-th anniversary Symposium

    SciTech Connect

    Potter, Gerald L; Bader, David C; Riches, Michael; Bamzai, Anjuli; Joseph, Renu

    2011-01-05

    Twenty years ago, W. Lawrence (Larry) Gates approached the U.S. Department of Energy (DOE) Office of Energy Research (now the Office of Science) with a plan to coordinate the comparison and documentation of climate model differences. This effort would help improve our understanding of climate change through a systematic approach to model intercomparison. Early attempts at comparing results showed a surprisingly large range in control climate from such parameters as cloud cover, precipitation, and even atmospheric temperature. The DOE agreed to fund the effort at the Lawrence Livermore National Laboratory (LLNL), in part because of the existing computing environment and because of a preexisting atmospheric science group that contained a wide variety of expertise. The project was named the Program for Climate Model Diagnosis and Intercomparison (PCMDI), and it has changed the international landscape of climate modeling over the past 20 years. In spring 2009 the DOE hosted a 1-day symposium to celebrate the twentieth anniversary of PCMDI and to honor its founder, Larry Gates. Through their personal experiences, the morning presenters painted an image of climate science in the 1970s and 1980s, that generated early support from the international community for model intercomparison, thereby bringing PCMDI into existence. Four talks covered Gates's early contributions to climate research at the University of California, Los Angeles (UCLA), the RAND Corporation, and Oregon State University through the founding of PCMDI to coordinate the Atmospheric Model Intercomparison Project (AMIP). The speakers were, in order of presentation, Warren Washington [National Center for Atmospheric Research (NCAR)], Kelly Redmond (Western Regional Climate Center), George Boer (Canadian Centre for Climate Modelling and Analysis), and Lennart Bengtsson [University of Reading, former director of the European Centre for Medium-Range Weather Forecasts (ECMWF)]. The afternoon session emphasized

  15. Astronomers to Mark 20th Anniversary of the Very Large Array

    NASA Astrophysics Data System (ADS)

    2000-07-01

    On August 23, scientists will mark the 20th anniversary of the National Science Foundation's Very Large Array (VLA), the most powerful, flexible and widely-used radio telescope in the world. "Twenty years ago, the VLA brought dramatic new observing capabilities to the world's astronomers, and today there is hardly a branch of astronomy that has not been profoundly impacted by the prolific research output of this radio telescope," said Dr. Paul Vanden Bout, Director of the National Radio Astronomy Observatory (NRAO). The anniversary will be marked in a ceremony at NRAO's Array Operations Center in Socorro, NM. The keynote speaker for this ceremony will be U.S. Senator Pete V. Domenici, R-NM. Also speaking will be Dr. Rita Colwell, NSF Director; Dr. Anneila Sargent, president-elect of the American Astronomical Society; Vanden Bout; Dr. Riccardo Giacconi, president of Associated Universities, Inc. (AUI); Dr. Paul Martin, chairman of the AUI board of trustees; and Dr. Miller Goss, NRAO's director of VLA/VLBA operations. "More than 2,200 researchers from hundreds of institutions around the world have used the VLA for more than 10,000 observing projects," said Vanden Bout. "Research conducted at the VLA has had a major impact across the entire breadth of astronomy, from nearby objects such as the Sun and planets of our own Solar System, to forming galaxies and quasars billions of light-years away in the farthest reaches of the Universe," Vanden Bout added. Major discoveries made by the VLA have ranged from the surprising detection of water ice on Mercury, the nearest planet to the Sun, to the first detection of radio emission from a Gamma Ray Burster in 1997. The VLA also discovered the first "Einstein Ring" gravitational lens in 1987, and the first "microquasar" within our own Milky Way Galaxy in 1994. Over the past two decades, the VLA also has made major contributions to our understanding of active regions on the Sun, the physics of superfast "cosmic jets" of material

  16. An End and a Beginning: The Fiftieth Anniversary of Brown v. Board of Education--The Landmark Case that Led to the Abolition of School Segregation

    ERIC Educational Resources Information Center

    Landman, James H.

    2004-01-01

    On May 17, 2004, the United States will observe the fiftieth anniversary of the Supreme Court's landmark decision in Brown v. Board of Education of Topeka, Kansas. By invalidating the doctrine of "separate but equal" in the field of public education, a doctrine that had been approved by the same court nearly sixty years earlier in Plessy v.…

  17. Learning to Fly: Family-Oriented Literacy Education in Schools. Celebrating the Tenth Anniversary of Hamburg's Family Literacy Project 2004-2014

    ERIC Educational Resources Information Center

    Rabkin, Gabriele, Ed.; Roche, Stephen, Ed.

    2014-01-01

    This book was published to mark the tenth anniversary of Hamburg's award-winning Family Literacy project (FLY). It includes contributions from key stakeholders--academics, teachers, parents and children--participating in the conceptualization and implementation of FLY in the city of Hamburg. FLY mainly targets people from socially disadvantaged…

  18. International Congress on the Occasion of the Thirtieth Anniversary of the Associated Schools Project. (Sofia, Bulgaria, September 12-16, 1983). Final Report.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France).

    This report of the Proceedings of an international congress to mark the 30th anniversary of the Associated Schools Project of UNESCO is divided into seven sections. Section I, an introduction, outlines the background of the congress and initial proceedings: the opening address, election of officers, presentation of the program and rules of…

  19. From Elite Traditions to Middle-Class Cultures: Images of Secondary Education in the Anniversary Books of a Finnish Girls' School, 1882-2007

    ERIC Educational Resources Information Center

    Nieminen, Marjo

    2016-01-01

    This article concentrates on visual sources relating to secondary education, and asks how a collection of photographs can be understood and interpreted as part of the institutional and collective memory of one Finnish girls' school. The photographs were published in the anniversary books of the school. They construct an entirety, where public…

  20. Once Upon a Time...Celebrating the Magic of Children's Books in Honor of the Twentieth Anniversary of Reading Is Fundamental.

    ERIC Educational Resources Information Center

    Rock, Victoria, Ed.

    Conceived as a twentieth anniversary tribute to the Reading Is Fundamental Program, this book contains a varied collection of stories, poems, and drawings by some of America's most famous authors and artists of books for children, relating real and imaginary childhood memories that celebrate the joys of reading and the magic of children's…

  1. Potpourri of comments about the fiber optic gyro for its 40th anniversary, and how fascinating it was and it still is!

    NASA Astrophysics Data System (ADS)

    Lefèvre, Hervé C.

    2016-05-01

    This 40th anniversary is the opportunity to recall how fascinating is the fiber-optic gyro with its potential perfection. Pure unaided strapdown inertial navigation yielding drift of less than one nautical mile in a month has been demonstrated in a laboratory. This paper also adds several comments about points that could be better known and should be outlined.

  2. Educating Black Librarians. Papers from the 50th Anniversary Celebration of the School of Library and Information Sciences, North Carolina Central University.

    ERIC Educational Resources Information Center

    Speller, Benjamin F., Jr., Ed.

    This document assembles 16 papers given at a 1989 symposium in honor of the 50th anniversary of the School of Library and Information Sciences at North Carolina Central University, Durham (NCCU). The papers examine the past, present, and future of the participation of African Americans in the field of library and information service. Titles…

  3. The First Seventy Years: Bryan Memorial Hospital School of Nursing and Bryan Memorial Hospital, 1926-1996. A Seventieth Anniversary Publication.

    ERIC Educational Resources Information Center

    Vontz, Marilyn J.

    Celebrating the 70th anniversary of Bryan Memorial Hospital School of Nursing (BMHSN) and Bryan Memorial Hospital, in Nebraska, this monograph reviews the development and achievements of the school and hospital. Chapter 1 (1900-1919) provides a history of nursing in the early 20th century, while chapter 2 (1920-1929) describes the establishment of…

  4. The Long Good-Bye: Why B. F. Skinner's "Verbal Behavior" Is Alive and Well on the 50th Anniversary of Its Publication

    ERIC Educational Resources Information Center

    Schlinger, Henry D.

    2008-01-01

    The year 2007 marked the 50th anniversary of the publication of B. F. Skinner's "Verbal Behavior", a book that by Skinner's own account was his most important. The received view, however, is that a devastating review by a young linguist not only rendered Skinner's interpretation of language moot but was also a major factor in ending the hegemony…

  5. An Index to the Caricatures in the "New York Review of Books" from Its Inception Through the Fifteenth Anniversary Issue (1963-1978).

    ERIC Educational Resources Information Center

    Drazan, Joseph Gerald; Sanguine, Phyllis

    This index identifies caricatures drawn by David Levine which are found in the "New York Review of Books" from its first issue in 1963 through the special fifteenth anniversary issue dated October 12, 1978. The index is arranged alphabetically by surname for each personality caricatured, with some cross references. The numbering system used refers…

  6. The Pleistocene glaciations as evidences of the rejuvenation of the Altai Mountains Province in direction opposite to the propagation of the deformation related to India-Eurasia collision

    NASA Astrophysics Data System (ADS)

    Agatova, A.; Nepop, R.

    2009-04-01

    of relative vertical displacement of tectonic blocks in scale of mountain ranges and intermontane depressions. This investigation revealed the varied tectonic movements within Altai Mountains Province. Obtained results are evidenced of consecutive increasing of mountain range altitudes from south-eastern part of Russian Altai to Gobi Altai where due to later uplift glaciation appeared just only in the late Pleistocene in spite of arid climate. These data according with the simplification of neotectonic structure of the Altai uplift and rejuvenation of sediment fillings of intermontane depressions in south-eastern direction argue for the rejuvenation of orogenic movements within Altai Mountains in the direction which is opposite to the propagation of the deformation related to India-Eurasia collision. This phenomenon can be explained on the basis of tectonic wave concept as the reflection of tectonic deformation wave from Western Siberia plate which cause following consecutive uplifting of southern mobile areas clamped between Djungar and Tuva-Mongolian microplates. This research was supported by RFBR (grant # 09-05-00932).

  7. Mesotherapy with an Intradermal Hyaluronic Acid Formulation for Skin Rejuvenation: An Intrapatient, Placebo-Controlled, Long-Term Trial Using High-Frequency Ultrasound.

    PubMed

    Tedeschi, Aurora; Lacarrubba, Francesco; Micali, Giuseppe

    2015-02-01

    Mesotherapy with hyaluronic acid (HA) is a treatment approach currently used for skin rejuvenation. High-frequency ultrasound (20-100 MHz) is a non-invasive technique that has been used to evaluate age-related dermal changes. The presence and the degree of a typical subepidermal low-echogenic band (SLEB) are photoaging related: the lower the SLEB echogenicity, the higher the photoaging. The aim of this trial was to evaluate, through ultrasound imaging, the long-term effects of microinjections of HA on SLEB echogenicity. Twenty-two women with clinical and ultrasound signs of moderate photoaging were enrolled in the study. Treatment consisted of multiple microinjections of HA salts of biotechnological origin on the dorsum of one hand, once weekly for 4 weeks and, successively, once monthly for 4 months (group A) or 9 months (group B). The dorsum of the other hand of each subject was injected with saline solution and used as a control. In all subjects, high-frequency ultrasound (22 MHz) was performed to evaluate SLEB echogenicity changes during treatment. Eighteen out of 22 patients completed the study. At the end of 4 weeks, an ultrasound increase of dermal echogenicity was observed in 13 subjects (seven of group A and six of group B), which we considered as "responders". In these patients, the Student's t-test showed a significant increase from baseline of SLEB pixel numbers of +24 % (P < 0.01) versus +6 % with placebo. In the same subjects, after an additional 4 months of monthly injections, the mean increase was +18 % (P < 0.05) versus +4 % with placebo. In patients from group B that completed 10 months of treatment, the increase from baseline of SLEB pixel numbers was +18 % (P < 0.05) versus 0 % with placebo. Our study suggests that mesotherapy with HA may effectively improve skin aging and photoaging, as supported by quantifiable ultrasound data showing significant changes in SLEB density over time. PMID:25539986

  8. The 50th Anniversary of the International Indian Ocean Expedition: An Update on Current Planning Efforts and Progress

    NASA Astrophysics Data System (ADS)

    Hood, Raleigh; D'Adamo, Nick; Burkill, Peter; Urban, Ed; Bhikajee, Mitrasen

    2014-05-01

    The International Indian Ocean Expedition (IIOE) was one of the greatest international, interdisciplinary oceanographic research efforts of all time. Planning for the IIOE began in 1959 and the project officially continued through 1965, with forty-six research vessels participating under fourteen different flags. The IIOE motivated an unprecedented number of hydrographic surveys (and repeat surveys) over the course of the expedition covering the entire Indian Ocean basin. And it was an interdisciplinary endeavor that embraced physical oceanography, chemical oceanography, meteorology, marine biology, marine geology and geophysics. The end of 2015 will mark the 50th Anniversary of the completion of the IIOE. In the 50 years since the IIOE three fundamental changes have taken place in ocean science. The first is the deployment of a broad suite of oceanographic sensors on satellites that have dramatically improved the characterization of both physical and biological oceanographic variability. The second is the emergence of new components of the ocean observing system, most notably remote sensing and Argo floats. And the third is the development of ocean modeling in all its facets from short-term forecasting to seasonal prediction to climate projections. These advances have revolutionized our understanding of the global oceans, including the Indian Ocean. Compared to the IIOE era, we now have the capacity to provide a much more integrated picture of the Indian Ocean, especially if these new technologies can be combined with targeted and well-coordinated in situ measurements. In this presentation we report on current efforts to motivate an IIOE 50th Anniversary Celebration (IIOE-2). We envision this IIOE-2 as a 5-year expedition and effort beginning in 2015 and continuing through to 2020. An important objective of our planning efforts is assessing ongoing and planned research activities in the Indian Ocean in the 2015 to 2020 time frame, with the goal of embracing and

  9. NRAO Salutes Past, Looks to Future In 50th-Anniversary Science Meeting

    NASA Astrophysics Data System (ADS)

    2007-06-01

    Radio telescopes now in operation or under construction will be indispensible to scientists wrestling with the big, unanswered questions of 21st-Century astrophysics. That was the conclusion of a wide-ranging scientific meeting held in Charlottesville, Virginia, June 18-21, to mark the 50th anniversary of the National Radio Astronomy Observatory (NRAO). 1957 Dedication Dedication of NRAO, 17 October 1957. Left to right: R.M. Emberson, L.V. Berkner, G.A. Nay, J.W. Findlay (seated in front of 140ft telescope model), N.L. Ashton, D.S. Heeschen, H. Hockenberry. CREDIT: NRAO/AUI/NSF Click on Image for Larger File ALMA Artist's conception of completed ALMA. CREDIT: NRAO/AUI/ESO Click on Image for Larger File (2.4 MB) Nearly 200 scientists from around the world heard presentations about the frontiers of astrophysics and how the challenges at those frontiers will be met. In specialties as disparate as seeking the nature of the mysterious Dark Energy that is speeding the Universe's expansion to unraveling the details of how stars and planets are formed, more than 70 presenters looked toward future research breakthroughs. "NRAO's telescopes have made landmark contributions to the vast explosion of astronomical knowledge of the past half- century, and we look eagerly to making even more important contributions in the coming decades," said Fred K.Y. Lo, NRAO's director. Over the four days of the meeting, discussions ranged from recollections of radio astronomy's pioneering days of vacuum-tube equipment and paper chart recorders to the design of telescopes that will produce amounts of data that will strain today's computers. Presenters pointed out that, in the coming decades, radio telescope observations will advance not only astronomy but also fields of basic physics such as gravitational radiation, particle physics, and the fundamental physical constants. "This meeting provided a great overview of where astrophysics stands today and where the challenges and opportunities of

  10. The 50th Anniversary of the First International Conference on Permafrost

    NASA Astrophysics Data System (ADS)

    Brown, J.

    2013-12-01

    This year marks the 50th anniversary of the First International Conference on Permafrost (ICOP) that was held at Purdue University on 11-15 November 1963. The conference was a historic event in that it brought together for the first time the leading researchers and practitioners from North America and other countries that had diverse interests and activities in the study and applications of perennially frozen ground, cold regions engineering and related laboratory investigations. The 285 registered participants represented engineers, researchers, manufacturers and builders from the USA (231), Canada (42), the USSR (5), Sweden (3) and Argentina, Austria, Great Britain, Japan, Norway, Poland, Switzerland, and West Germany. The conference was organized by the Building Research Advisory Board of the U.S. National Academy of Sciences-National Research Council (NAS-NRC). The carefully edited volume, published in 1966 by the NAS, is considered to be the first multi-national, English-language collection of papers devoted entirely to permafrost topics. The 100 published papers followed closely the actual conference venue and panel discussions: soils and vegetation (9), massive ground ice (10), geomorphology (16), phase equilibrium and transition (8), thermal aspects (8), physico-mechanical properties (7), exploration and site selection (11), sanitary and hydraulic engineering (14), and earthwork and foundations (17). This 1963 Purdue conference essentially broke the 'ice' between East and West permafrost researchers and set the stage for the Second ICOP that was held in 1973 in Yakutsk, Siberia, and represented the first large international conference held in the restricted area of Siberia. All subsequent conferences maintained the interdisciplinary principles set forth at Purdue: two more in the United States (Fairbanks 1983, 2008), two in Canada (Edmonton 1978, Yellowknife 1998), and one in Trondheim, Norway (1988), Beijing, China (1993), and Zurich, Switzerland (2003

  11. The Dokuchaev hypothesis as a basis for predictive digital soil mapping (on the 125th anniversary of its publication)

    NASA Astrophysics Data System (ADS)

    Florinsky, I. V.

    2012-04-01

    Predictive digital soil mapping is widely used in soil science. Its objective is the prediction of the spatial distribution of soil taxonomic units and quantitative soil properties via the analysis of spatially distributed quantitative characteristics of soil-forming factors. Western pedometrists stress the scientific priority and principal importance of Hans Jenny's book (1941) for the emergence and development of predictive soil mapping. In this paper, we demonstrate that Vasily Dokuchaev explicitly defined the central idea and statement of the problem of contemporary predictive soil mapping in the year 1886. Then, we reconstruct the history of the soil formation equation from 1899 to 1941. We argue that Jenny adopted the soil formation equation from Sergey Zakharov, who published it in a well-known fundamental textbook in 1927. It is encouraging that this issue was clarified in 2011, the anniversary year for publications of Dokuchaev and Jenny.

  12. 500(th) anniversary of the birth of the precursor of modern cardiology: Josephus Struthius Polonus (1510-1568).

    PubMed

    Grzybowski, Andrzej; Sak, Jarosław; Pawlikowski, Jakub

    2011-01-01

    In this article, the authors take a closer look at the figure of Josephus Struthius Polonus (1510- -1568), one of the most famous physicians of the European Renaissance, on the 500(th) anniversary of his birth. Struthius became famous for his critical analysis of Galen's works and his own research into the circulatory system. The analysis of Struthius's scientific achievements leads to a conclusion that he was one of the pioneers of modern cardiology. He was a precursor of William Harvey (1578-1657) in studying the cardiovascular system, and the first person in the history of European medicine to present the pulse in a graphic form. He also presented similar ideas to those proposed in the 19(th) century by the inventor of the sphygmograph Karl von Vierodt (1818-1884), and the inventor of the polygraph Sir James Mackenzie (1853-1925). PMID:21948000

  13. Magnetotelluric deep soundings, gravity and geoid in the south São Francisco craton: Geophysical indicators of cratonic lithosphere rejuvenation and crustal underplating

    NASA Astrophysics Data System (ADS)

    Pinto, Luis Gustavo Rodrigues; de Pádua, Marcelo Banik; Ussami, Naomi; Vitorello, Ícaro; Padilha, Antonio Lopes; Braitenberg, Carla

    2010-09-01

    positive geoid anomaly (+ 10 m) and pre-tholeiites (age > 138 Ma), carbonatites and kimberlites along the west African continental margin (Angola and Namibia) reinforces the presumed age of the São Francisco-Congo craton rejuvenation to be prior to its fragmentation in the Lower Cretaceous.

  14. MABAHISS/John Murray 50th Anniversary: Marine Science of the North West Indian Ocean and Adjacent Waters. Report of a Symposium on the Occasion of the 50th Anniversary of the MABAHISS/John Murray Expedition (1933/34) (Alexandria, Egypt, September 3-7, 1983). Unesco Reports in Marine Science, No. 31.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France). Div. of Marine Sciences.

    An international symposium was convened to celebrate the 50th anniversary of the John Murray Expedition to the Indian Ocean on board the Egyptian research vessel Mabahiss (1933-1934). This report describes the symposium and provides abstracts and syntheses of the papers presented in the various marine scientific disciplines covering the areas of…

  15. [Christian Andreas Cothenius (1708-1789). A pro-memoria on the occasion of the 200th anniversary of his death].

    PubMed

    Völker, A

    1990-04-01

    The 200th anniversary of the death of Christian Andreas Cothenius gave occasion to appreciate life and work of this personage of a physician. Cothenius maintained manifold connections to Halle, of which the golden doctorate and the heritage of the pharmaceutic enterprises of his teacher Friedrich Hoffmann were treated in this place. The picture of the local relations was supplemented by the history of the Cothenius medal which is today awarded by the Leopoldina of Halle. PMID:2198714

  16. [70th anniversary of 111th Main Federal Center of medical and forensic examination of the Ministry of Defence of the Russian Federation].

    PubMed

    Pinchuk, P V; Fokin, A A

    2013-03-01

    The article is devoted to 70th anniversary of the head state forensic expert institution of the Ministry of Defence of the Russian Federation--111th Main state center of medicolegal and criminalistic examination of the Ministry of Defence of the Russian Federation. Some information about historical aspects of functioning of the institution and its activity at the present stage and in conditions of the reform of the Armed Forces of the Russian Federation is given. PMID:23808218

  17. Rejuvenating clinician-scientist training.

    PubMed

    Ambati, Balamurali K; Cahoon, Judd

    2014-03-01

    Clinician-scientists are becoming increasingly rare in medicine as a whole, but especially in ophthalmology. There is a structural gap between MD-PhD training and K-series awards where interested candidates go through residency and fellowship without any structured research exposure or involvement. Furthermore, the success rate of the MD-PhD and K awards leaves much to be desired. The authors propose a redeployment of training resources to reconfigure residency and fellowship training programs for interested candidates with sufficient additional time for a credible research project, augmented salary, and sound mentoring. Opportunities for research training in nontraditional pathways to diversify skill sets and build interdisciplinary teams also would be a prime objective of this novel "Learn-and-Earn" approach. PMID:24681976

  18. How to Rejuvenate Hohum Teachers.

    ERIC Educational Resources Information Center

    Johnson, Sandy

    To motivate teachers toward quality performance, administrators must follow effective organizational practices and methods for professional development. This report describes how Hampshire County, West Virginia, schools implement ideas that increase productivity. Among ideas used were those of James Lewis, Jr., whose book, Excellent Organizations,…

  19. "Tired" Professors Can Be Rejuvenated

    ERIC Educational Resources Information Center

    Seldin, Peter

    2008-01-01

    At a recent national conference, colleagues from different academic disciplines but all worked in college or university teaching-improvement programs found that the subject most frequently discussed was how to improve the teaching of "tired" faculty members. Tired faculty members are most often senior professors who have worked at their…

  20. Rejuvenating a Career College Library

    ERIC Educational Resources Information Center

    Harrison, Tiffany; Ward, Randall; Pace, Sean; Cornelius, Andi

    2009-01-01

    The librarian for the Stevens-Henager College, Murray, Utah campus was hired in the spring of 2008 and given the task of maintaining and improving the college's library and bookstore. It was soon discovered that many areas needed improvement (processes, outreach, policies, personnel, work-flow, etc.) Fortunately, she possessed skills from previous…

  1. Synthetic Fillers for Facial Rejuvenation.

    PubMed

    Lee, Johnson C; Lorenc, Z Paul

    2016-07-01

    Soft tissue filler procedures have increased dramatically in popularity in the United States. Synthetic fillers such as calcium hydroxyapatite (CaHA), polymethyl methacrylate (PMMA), and poly-l-lactic acid (PLLA), and silicone provide initial volume replacement but have an additional biostimulatory effect to supplement facial volumization. Indications include human immunodeficiency virus lipoatrophy and nasolabial folds for CaHA and PLLA and atrophic acne scars for PMMA. Most clinical use of these synthetic fillers is in an off-label fashion. Beyond the proper choice of a synthetic filler, careful consideration of dilution, injection method, and postprocedural care allows for successful and consistent results. PMID:27363763

  2. Academics First: Rejuvenating Athletics Reform.

    ERIC Educational Resources Information Center

    Brand, Myles

    2001-01-01

    Discusses how two proposed solutions to the escalation of college athletics, radically downsizing or professionalizing, are flawed, and proposes ways for Division I-A college presidents to work together and through their athletics conferences to stem the unhealthy expansion of college football and basketball. (EV)

  3. Rejuvenating Bi(d)ology.

    PubMed

    Zinkel, S S; Yin, X M; Gross, A

    2013-07-01

    The BH3-only Bid protein is a critical sentinel of cellular stress in the liver and the hematopoietic system. Bid's initial 'claim to fame' came from its ability-as a caspase-truncated product-to trigger the mitochondrial apoptotic program following death receptor activation. Today we know that Bid can response to multiple types of proteases, which are activated under different conditions such as T-cell activation, ischemical reperfusion injury and lysosomal injury. Activation of the mitochondrial apoptotic program by Bid-via its recently identified receptor mitochondrial carrier homolog 2-involves multiple mechanisms, including release of cytochrome c and second mitochondria-derived activator of caspase (Smac), alteration of mitochondrial cristae organization, generation of reactive oxygen species and engagement of the permeability transition pore. Bid is also emerging-in its full-length form-as a pivotal sentinel of DNA damage in the bone marrow regulated by the ataxia telangiectasia mutated (ATM)/ataxia telangiectasia and Rad3-related (ATR) kinases. The ATM/ATR-Bid pathway is critically involved in preserving the quiescence and survival of hematopoietic stem cells both in the absence and presence of external stress, and a large part of this review will be dedicated to recent advances in this area of research. PMID:23069655

  4. Origin of the Ciomadul Dacite, Carpathian-Pannonian Region, Eastern-Central Europe: Rejuvenation of a Pre-Existing Crystal Mush

    NASA Astrophysics Data System (ADS)

    Kiss, B.; Harangi, S.; Molnar, K.; Jankovics, E. M.; Lukacs, R.; Ntaflos, T.

    2012-12-01

    represent evolved melt in a crystal mush body rather than melting product of the crystal phases. Thermobarometric calculations yield 2.68±0.47 kbar pressure and 735±26°C temperature, which is close to the granitic solidus. In certain crystal clots, plagioclases show strongly resorbed margin with sieved texture and an overgrowth zone with distinct composition, e.g., higher FeO content resembling the newly formed plagioclase microphenocrysts in the host rock. The amphiboles are strongly opacitized and often have coarse-grained clinopyroxene corona. All of these suggest interaction between the crystal mush and hot mafic magma. The amphibole-plagioclase thermometry in the host rock resulted in a minimum crystallization temperature of 840±11°C, significantly higher than the values got for the crystal clots. In summary, the Ciomadul dacite contains vast amount of low-temperature, disseminated crystal mush fragments (up to 50 vol% of the "phenocrysts"), which were remobilized by hot mafic magmas. This could lead to the rejuvenation of the magmatic system and an eruption phase, possibly after a long repose time.

  5. The 30th anniversary of Campylobacter, Helicobacter, and Related Organisms workshops—what have we learned in three decades?

    PubMed Central

    Gaynor, Erin C.; Szymanski, Christine M.

    2012-01-01

    As we commemorate the 30th anniversary of the Campylobacter, Helicobacter, and Related Organisms (CHRO) workshops with this special Frontiers edition, we look back upon three decades of research and provide some highlights from the 16th International CHRO meeting. Although Theodor Escherich himself provided drawings of campylobacters back in the 1880s, Campylobacter jejuni was not identified until the 1950s. Helicobacter pylori was first described to be the causative agent of stomach ulcers at a CHRO meeting by Barry Marshall and Robin Warren—who later received the Nobel Prize for their findings that bacteria could cause diseases previously believed to be caused by human factors. Now, several genome sequences for campylobacters, helicobacters, and related organisms are available and we have moved into an era examining the intersection between host microbial ecology and pathogen infection. Both pioneers and new investigators in the CHRO research field continue to obtain “unexpected results” demonstrating that campylobacters and helicobacters do not follow classic paradigms of other well-characterized gastrointestinal pathogens and we are learning that there is a plethora of interesting related organisms beyond C. jejuni and H. pylori. This review summarizes recent discoveries in CHRO research and the exciting directions ahead. PMID:22919612

  6. Memories of a senior scientist: on passing the fiftieth anniversary of the beginning of deciphering the genetic code.

    PubMed

    Lengyel, Peter

    2012-01-01

    2011 marked the fiftieth anniversary of breaking the genetic code in 1961. Marshall Nirenberg, the National Institutes of Health (NIH) scientist who was awarded the Nobel Prize in Physiology or Medicine in 1968 for his role in deciphering the code, wrote in 2004 a personal account of his research. The race for the code was a competition between the NIH group and Severo Ochoa's laboratory at New York University (NYU) School of Medicine, where I was a graduate student and conducted many of the experiments. I am now 83 years old. These facts prompt me to recall how I, together with Joe Speyer, an instructor in the Department of Biochemistry at NYU, unexpectedly became involved in deciphering the code, which also became the basis of my PhD thesis. Ochoa won the Nobel Prize in Physiology or Medicine in 1959 for discovering polynucleotide phosphorylase (PNP), the first enzyme found to synthesize RNA in the test tube. The story of how PNP made the deciphering of the code feasible is recalled here. PMID:22994487

  7. Proceedings of the 20th anniversary conference: Water management in the '90s. A time for innovation

    SciTech Connect

    Hon, K.

    1993-01-01

    This proceedings contains papers presented at the 20th anniversary conference of ASCE's Water Resources Planning and Management Division held in Seattle, Washington, May 1-5, 1993. The conference theme is an acknowledgement of the need for water resources professionals to face major challenges in managing diminishing supplies for ever-increasing demands, in protecting valuable watersheds from urban and agricultural pollution, and in building and maintaining critical infrastructure with limited financial resources. The papers in this proceedings reflect a practical, problem-solving focus with emphasis on novel solutions for current and near future challenges. Included are papers from three symposia held as part of the conference: (1) Urban runoff and the Environment, (2) Water Supply and Conservation, and (3) the National Drought Study. Other topics covered include: computer-aided decision support systems, the Endangered Species Act impact on major water systems, international disasters, geographic information systems, global warming, and hydropower planning. Individual papers are processed separately for inclusion in the appropriate data bases.

  8. Advanced optical correlation and digital methods for pattern matching—50th anniversary of Vander Lugt matched filter

    NASA Astrophysics Data System (ADS)

    Millán, María S.

    2012-10-01

    On the verge of the 50th anniversary of Vander Lugt’s formulation for pattern matching based on matched filtering and optical correlation, we acknowledge the very intense research activity developed in the field of correlation-based pattern recognition during this period of time. The paper reviews some domains that appeared as emerging fields in the last years of the 20th century and have been developed later on in the 21st century. Such is the case of three-dimensional (3D) object recognition, biometric pattern matching, optical security and hybrid optical-digital processors. 3D object recognition is a challenging case of multidimensional image recognition because of its implications in the recognition of real-world objects independent of their perspective. Biometric recognition is essentially pattern recognition for which the personal identification is based on the authentication of a specific physiological characteristic possessed by the subject (e.g. fingerprint, face, iris, retina, and multifactor combinations). Biometric recognition often appears combined with encryption-decryption processes to secure information. The optical implementations of correlation-based pattern recognition processes still rely on the 4f-correlator, the joint transform correlator, or some of their variants. But the many applications developed in the field have been pushing the systems for a continuous improvement of their architectures and algorithms, thus leading towards merged optical-digital solutions.

  9. New K-Ar ages and the geologic evidence against rejuvenated-stage volcanism at Haleakalā, East Maui, a postshield-stage volcano of the Hawaiian island chain

    USGS Publications Warehouse

    Sherrod, David R.; Nishimitsu, Yoshitomo; Tagami, Takahiro

    2003-01-01

    The age of the Kula/Hāna boundary is ca. 0.15–0.12 Ma; thus, volcanic quiescence of only ∼0.03 m.y. separates the two formations, much shorter than the previously known limit of 0.25–0.30 m.y. The brevity of this hiatus, coupled with coincident vent loci and broadly similar geochemical characteristics for the Hāna and the upper part of the Kula Volcanics, indicates that the Hāna Volcanics unit comprises deposits of postshield-stage volcanism that has waned substantially since ca. 0.4–0.3 Ma. Haleakalā has not yet begun a classically defined rejuvenated stage. Our findings support recent numerical modeling of plume-lithosphere interactions that predict that Haleakalā is near the end of its postshield growth.

  10. Infographic: How Sex and Gender Influence Health and Disease

    MedlinePlus

    ... Staff ORWH 25th Anniversary Infographic: How Sex and Gender Influence Health and Disease Share: Enlarge Infographic (PDF, ... Enlarge Infographic (PDF, 558 KB) Resources Sex and Gender Differences from A to Z: Get the facts. ...

  11. STS-8 postal Stamp envelope

    NASA Technical Reports Server (NTRS)

    1983-01-01

    STS-8 postal Stamp envelope with Challenger insignia, USA eagle stamp, 25th NASA anniversary stamp. The envelope is stamped with various postmarks, one saying Kennedy Space Center, Fl., another saying 'Returned to earth, Edwards AFB, CA'.

  12. Our First Quarter Century of Achievement... Just the Beginning

    NASA Technical Reports Server (NTRS)

    1983-01-01

    Space flight, space science, space applications, aeronautics, tracking and data acquisition, international programs, technology utilization, NASA installations, the NASA launch record, astronauts, and the fine arts program are reviewed in light of NASA's 25th anniversary.

  13. [Fiftieth anniversary of Hans Berger's publication of the electroencephalogram. His first records in 1924--1931 (author's transl)].

    PubMed

    Jung, R; Berger, W

    1979-12-01

    For the fiftieth anniversary of Berger's first EEG publication, some of his early recordings obtained between 1924 and 1931 are discussed and illustrated. Examples of his protocols from the Freiburg Berger Archives are reproduced. Three types of Berger's early investigations are described: (1) String-galvanometer recordings obtained between 1924 and 1926, mainly from trephined patients with cerebral diseases, which usually showed brain waves slowed to 6--8 per second; (2) Direct recordings from the cortex and white matter proving the cortical origin of the EEG in 1930; (3) Typical unpublished EEG recordings of epileptics and of petit-mal attacks obtained in 1930 and 1931. Berger's first six papers published between 1929 and 1933 described nearly all the main EEG findings of cerebral diseases and the EEG alterations of normals during attention, sleep, and narcosis, but they did not report on convulsive potentials in the EEGs of epileptics. Berger had, however, obtained excellent records of epileptic EEG features, here depicted in Figs. 4 through 7. These remained unpublished until 1933 and 1938, because Berger suspected that they contained artifacts caused by blinks and facial movements which he had recorded in his controls (Fig. 4). Only in 1933, after other authors had described large amplitudes of convulsive potentials in the cortex of animals, did Berger publish parts of the EEGs of a petit-mal attack and of focal attacks in progressive paresis. In 1938, Berger presented the EEG of the beginning of a petit-mal attack with large 3/s spikes and waves recorded in 1931 which were similar to those described by Gibbs and coworkers in 1935. In 1933 and 1938, Berger interpreted the abnormal brain potentials of epileptics as signs of a preconvulsive state of the forebrain and suggested that the periods of 3/s waves were cortical correlates of an epileptic absence. PMID:398691

  14. dbPTM 2016: 10-year anniversary of a resource for post-translational modification of proteins.

    PubMed

    Huang, Kai-Yao; Su, Min-Gang; Kao, Hui-Ju; Hsieh, Yun-Chung; Jhong, Jhih-Hua; Cheng, Kuang-Hao; Huang, Hsien-Da; Lee, Tzong-Yi

    2016-01-01

    Owing to the importance of the post-translational modifications (PTMs) of proteins in regulating biological processes, the dbPTM (http://dbPTM.mbc.nctu.edu.tw/) was developed as a comprehensive database of experimentally verified PTMs from several databases with annotations of potential PTMs for all UniProtKB protein entries. For this 10th anniversary of dbPTM, the updated resource provides not only a comprehensive dataset of experimentally verified PTMs, supported by the literature, but also an integrative interface for accessing all available databases and tools that are associated with PTM analysis. As well as collecting experimental PTM data from 14 public databases, this update manually curates over 12 000 modified peptides, including the emerging S-nitrosylation, S-glutathionylation and succinylation, from approximately 500 research articles, which were retrieved by text mining. As the number of available PTM prediction methods increases, this work compiles a non-homologous benchmark dataset to evaluate the predictive power of online PTM prediction tools. An increasing interest in the structural investigation of PTM substrate sites motivated the mapping of all experimental PTM peptides to protein entries of Protein Data Bank (PDB) based on database identifier and sequence identity, which enables users to examine spatially neighboring amino acids, solvent-accessible surface area and side-chain orientations for PTM substrate sites on tertiary structures. Since drug binding in PDB is annotated, this update identified over 1100 PTM sites that are associated with drug binding. The update also integrates metabolic pathways and protein-protein interactions to support the PTM network analysis for a group of proteins. Finally, the web interface is redesigned and enhanced to facilitate access to this resource. PMID:26578568

  15. dbPTM 2016: 10-year anniversary of a resource for post-translational modification of proteins

    PubMed Central

    Huang, Kai-Yao; Su, Min-Gang; Kao, Hui-Ju; Hsieh, Yun-Chung; Jhong, Jhih-Hua; Cheng, Kuang-Hao; Huang, Hsien-Da; Lee, Tzong-Yi

    2016-01-01

    Owing to the importance of the post-translational modifications (PTMs) of proteins in regulating biological processes, the dbPTM (http://dbPTM.mbc.nctu.edu.tw/) was developed as a comprehensive database of experimentally verified PTMs from several databases with annotations of potential PTMs for all UniProtKB protein entries. For this 10th anniversary of dbPTM, the updated resource provides not only a comprehensive dataset of experimentally verified PTMs, supported by the literature, but also an integrative interface for accessing all available databases and tools that are associated with PTM analysis. As well as collecting experimental PTM data from 14 public databases, this update manually curates over 12 000 modified peptides, including the emerging S-nitrosylation, S-glutathionylation and succinylation, from approximately 500 research articles, which were retrieved by text mining. As the number of available PTM prediction methods increases, this work compiles a non-homologous benchmark dataset to evaluate the predictive power of online PTM prediction tools. An increasing interest in the structural investigation of PTM substrate sites motivated the mapping of all experimental PTM peptides to protein entries of Protein Data Bank (PDB) based on database identifier and sequence identity, which enables users to examine spatially neighboring amino acids, solvent-accessible surface area and side-chain orientations for PTM substrate sites on tertiary structures. Since drug binding in PDB is annotated, this update identified over 1100 PTM sites that are associated with drug binding. The update also integrates metabolic pathways and protein–protein interactions to support the PTM network analysis for a group of proteins. Finally, the web interface is redesigned and enhanced to facilitate access to this resource. PMID:26578568

  16. CSEWG SYMPOSIUM, A CSWEG RETROSPECTIVE. 35TH ANNIVERSARY CROSS SECTION EVALUATION WORKING GROUP, NOV. 5, 2001, BROOKHAVEN NATIONAL LABORATORY.

    SciTech Connect

    DUNFORD, C.; HOLDEN, N.; PEARLSTEIN, S.

    2001-11-05

    This publication has been prepared to record some of the history of the Cross Section Evaluation Working Group (CSEWG). CSEWG is responsible for creating the evaluated nuclear data file (ENDF/B) which is widely used by scientists and engineers who are involved in the development and maintenance of applied nuclear technologies. This organization has become the model for the development of nuclear data libraries throughout the world. The data format (ENDF) has been adopted as the international standard. On November 5, 2001, a symposium was held at Brookhaven National Laboratory to celebrate the 50 th meeting of the CSEWG organization and the 35 th anniversary of its first meeting in November 1966. The papers presented in this volume were prepared by present and former CSEWG members for presentation at the November 2001 symposium. All but two of the presentations are included. I have included an appendix to list all of the CSEWG members and their affiliations, which has been compiled from the minutes of each of the CSEWG meetings. Minutes exist for all meetings except the 4 th meeting held in January 1968. The list includes 348 individuals from 71 organizations. The dates for each of the 50 CSEWG meetings are listed. The committee structure and chairmen of all committees and subcommittees are also included in the appendix. This volume is dedicated to three individuals whose foresight and talents made CSEWG possible and successful. They are Henry Honeck who lead the effort to develop the ENDF format and the CSEWG system, Ira Zartman, the Atomic Energy Commission program manager who provided the programmatic direction and support, and Sol Pearlstein who led the development of the CESWG organization and the ENDF/B evaluated nuclear data library.

  17. Thomas Willis, a pioneer in translational research in anatomy (on the 350th anniversary of Cerebri anatome).

    PubMed

    Arráez-Aybar, Luis-Alfonso; Navia-Álvarez, Pedro; Fuentes-Redondo, Talia; Bueno-López, José-L

    2015-03-01

    The year 2014 marked the 350th anniversary of the publication in London of Cerebri anatome, a ground-breaking work of neuroscience heavily influenced by the political and cultural context of Baroque Europe and mid-17th century England. This article aims to review the work of the English physician and anatomist Thomas Willis, specifically with regard to the contents of his Cerebri anatome. Willis's academic and professional career was influenced by the turbulent period of the English Civil War during which he studied medicine. Willis went from chemistry to dissection arguably because of his need to justify the body-brain-soul relationship. As a result, he became a fellow of a select club of eminent experimentalists, and afterward was a Fellow of the Royal Society. Later on, he went to London, leaving the academic life to dedicate himself fully to the profession of medicine. As a physician, Willis did not base his practice on aphorisms but on a 'bench to bedside' approach to medicine, while studying neuroanatomy--covering embryology, comparative anatomy and pathological anatomy--as a basis for the comprehension of neurological pathology. He developed innovative anatomical methods for the preservation and dissection of the brain, injection of coloured substances and illustration of his findings. In Cerebri anatome, Willis recognized the cerebral cortex as the substrate of cognition. He also claimed that the painful stimuli came from the meninges, but not from the brain itself. He explained for the first time the pathological and functional meaning of the brain's circular arterial anastomosis, which is named after him. He also specified some features of the cranial origin of the sympathetic nerves and coined the term 'neurologie'. Cerebri anatome marked the transition between the mediaeval and modern notions of brain function, and thus it is considered a cornerstone of clinical and comparative anatomy of the nervous system. The new contributions and methods employed by

  18. 50th Anniversary of the first successful permanent pacemaker implantation in the United States: historical review and future directions.

    PubMed

    Beck, Hiroko; Boden, William E; Patibandla, Sushmitha; Kireyev, Dmitriy; Gutpa, Vipul; Campagna, Franklin; Cain, Michael E; Marine, Joseph E

    2010-09-15

    June 2010 marks the 50th anniversary of the first successful human cardiac pacemaker implantation in the United States. On June 6, 1960, in Buffalo, New York, Dr. William Chardack implanted a pacemaker, designed and built by Wilson Greatbatch, an electrical engineer and inventor, in a 77-year old man with complete atrioventricular block, extending the patient's life by 18 months. This landmark event ushered in a new era of implantable cardiac pacemakers with batteries and leads of high reliability and increasing durability. Over the past half century, the field of electrophysiology and implantable devices for the management of cardiac conduction disturbances has evolved dramatically. Today's pacemakers include increasingly complex features such as telemetry monitoring, auto programmability, and hemodynamic sensors. New-generation leads present a sophisticated design with improved geometry and steroid-eluting tips to reduce chronic inflammation, maintaining a low pacing threshold and high sensing capability. The lithium iodide battery remains the mainstay of implantable pacemaker systems, exhibiting a multiple-year lifespan, slow terminal decay, and a reduced size and cost of production. Although Greatbatch's first successful pacemaker implantation remains a seminal scientific contribution to modern cardiovascular disease management, emerging developments in this field may challenge its preeminence. Important challenges such as imaging compatibility, lead durability, and infection prevention are being addressed. Novel concepts such as leadless and biologic pacing are under active investigation. In conclusion, Greatbatch's historic achievement 50 years ago reminds us that technologic progress is timeless, as efforts to enhance clinical outcomes and the quality of life continue unimpeded into the 21st century. PMID:21391322

  19. The 40 anniversary of the 1976 Friuli earthquake: a look back for empowering the next generation to the reduction of seismic risk

    NASA Astrophysics Data System (ADS)

    Saraò, Angela; Barnaba, Carla; Peruzza, Laura

    2016-04-01

    On 6 May 1976 an Ms=6.5 earthquake struck the Friuli area (NE Italy), causing about 1,000 casualties, and widespread destruction. Such event is the largest so far recorded in Northern Italy. After 40 years, the memory of a devastating earthquake remains in the urbanization, and in the people that lived that dreadful experience. However, the memories tend to vanish with the quake survivors demise and the celebration of the anniversary become a good opportunity to refresh the earthquake history, and the awareness of living in a seismic prone area. As seismologists, we believe that the seismic risk reduction starts from the education of the next generation. For this reason, we decided to celebrate the 40 anniversary planning a special educational campaign, mainly devoted to the schools and the young people, but it will give us the opportunity to check and, if necessary to raise, the level of seismic awareness of the local communities. The activities started on May 2015, with labs and lessons held in some schools, and the creation of a blog (https://versoi40anni.wordpress.com) to collect news, photos, video and all the materials related to the campaign. From February to May 2016, one day per week, we will open our seismological lab to the school visits, so that students can meet the seismologists, and we will cooperate with local science museums to enlarge the training offers on the earthquake topics. By continuing the efforts of our previous educational projects, the students of a school located in Gemona del Friuli, one of the small town destroyed by the 1976 earthquake, will be deeply involved in experimental activities, like seismic noise measurements for microzonation studies, so to be an active part of the seismic mitigation process. This and some other activities developed for the celebration of the 40 anniversary of the Friuli earthquake will be illustrated in this presentation.

  20. [In the 100 birth anniversary of the pioneer of stereotactic brain surgery in Poland professor Oskar Liszka. Functional neurosurgery in Poland and in Krakow].

    PubMed

    Stachura, Krzysztof

    2016-01-01

    This article is the report from the meeting of the Medical Society of Cracow, that has been devoted to the 100 birth anniversary of Oskar Liszka, Assoc. Prof., MD. In the course of the meeting Professor Oskar Liszka's figure has been reminded and his work as a pioneer of stereotactic surgery in Poland has been discussed. In the next two sections, the development of functional neurosurgery in Poland and achievements in this field in the Department of Neurosurgery and Neurotraumatology of Jagiellonian University Collegium Medicum in Krakow have been presented. PMID:27197434