Science.gov

Sample records for 25th anniversary rejuvenation

  1. Apollo 11 25th Anniversary logo

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This Official NASA commemorative logo marks the 25th anniversary of the first lunar landing. The design incorporates an eagle, from the original Apoll 11 crew insignia, descending toward the lunar surface with an olive branch, symbolizing America's peaceful mission in space. Alternative Headquarters number is 93-HC-312 or 93-H-336.

  2. Hubble 25th Anniversary: NASA Social at Goddard

    NASA Video Gallery

    NASA's Hubble Space Telescope celebrated its 25th anniversary on April 24, 2015. To mark the occasion, NASA's Goddard Space Flight Center in Greenbelt, Maryland -- home of Hubble operations -- host...

  3. 25th anniversary of the Gagarin Cosmonaut Training Center

    NASA Technical Reports Server (NTRS)

    Goreglyad, I.; Shonin, G.

    1985-01-01

    Interviews with retired Major General of Aviation L. Goreglyad and pilot-cosmonaut with the 25th anniversary of the establishment of the Gagarin Cosmonaut Training Center. Major-General Goreglyad, one of the Center's founders, tells of its development. Major General Shonin, one of the first cosmonauts to train there, tells of the tests and procedures leading to his acceptance as a trainee.

  4. Army Medical Department Lessons Learned Program marks 25th anniversary.

    PubMed

    Cannon, David W; McCollum, Jeffery

    2011-11-01

    The year 2010 marked the 25th anniversary of the Center for Army Lessons Learned (CALL) as well as the Army Medical Department (AMEDD) Center and School's Lessons Learned Division. In the aftermath of Operation Urgent Fury in 1983, the Army recognized the need to create an organization whose sole purpose was to collect, review, and analyze lessons learned and created the CALL in 1985 at Fort Leavenworth, Kansas. The AMEDD followed suit and established the Medical Information System/AMEDD Lessons Learned office under the Directorate of Evaluation and Standardization to research and compile lessons learned as the AMEDD's point of contact for the CALL program. Over these past 25 years the AMEDD Center and School Lessons Learned program evolved and underwent organizational realignments, but the overall mission continues to promote changes either directly or indirectly in the AMEDD's Doctrine, Organizations, Training, Leader Development, Materiel, Personnel and Facilities domains and capabilities to provide combat health service support on the battlefield. PMID:22165647

  5. 76 FR 67799 - Pricing for the American Eagle 25th Anniversary Silver Coin Set

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for the American Eagle 25th Anniversary Silver Coin Set AGENCY: United States... price of the American Eagle 25th Anniversary Silver Coin Set. The coin set will be offered for sale at...

  6. National Center for Biotechnology Information Celebrates 25th Anniversary | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn JavaScript on. National Center for Biotechnology Information Celebrates 25th Anniversary Past Issues / Winter 2014 ... Photo courtesy of NLM The National Center for Biotechnology Information (NCBI), a component of NLM, celebrated its ...

  7. Symposium commemorating the 25th anniversary of the discovery of mendelevium

    SciTech Connect

    Seaborg, G.T.

    1980-01-01

    The Symposium honoring the 25th Anniversary of the discovery of mendelevium was held at the Lawrence Berkeley Laboratory on March 28, 1980. The following three papers were presented: Chemical Properties of Mendelevium; Nuclear Properties of Mendelevium; and Radioactive Decay of Md Isotopes. Besides these papers there were introductory remarks, reminiscences, and concluding remarks.

  8. Alumni of High School Internship Program Return for 25th Anniversary to Inspire Current Students | Poster

    Cancer.gov

    The Building 549 auditorium is often packed with high school interns eager to hear a scientific lecture. On April 22, however, the room swelled with interns spanning a wider age range. At the 25th Werner H. Kirsten Student Intern Program (WHK SIP) Anniversary Symposium, incoming, current, and former interns gathered to celebrate the program, which has provided biomedical research experience for local high school seniors.

  9. Hubble’s 25th Anniversary: A Quarter-Century of Discovery and Inspiration

    NASA Astrophysics Data System (ADS)

    Straughn, Amber; Jirdeh, Hussein

    2015-01-01

    April 24, 2015 marks the 25th anniversary of the launch of the Hubble Space Telescope. In its quarter-century in orbit, the Hubble Space Telescope has transformed the way we understand the Universe, helped us find our place among the stars, and paved the way to incredible advancements in science and technology. NASA and ESA, including STScI and partners, will use the 25th anniversary of Hubble's launch as a unique opportunity to communicate to the widest possible audience the significance of the past quarter-century of discovery with the Hubble Space Telescope and to highlight that Hubble will continue to produce groundbreaking science results. We will enhance public understanding of Hubble's many contributions to the scientific world, and will capitalize on Hubble's cultural popularity by emphasizing its' successor, the James Webb Space Telescope. This poster highlights many of the upcoming opportunities to join in the anniversary activities, both in-person and online. Find out more at hubble25th.org and follow #Hubble25 on social media.

  10. [The Citizen Constitution and the 25th anniversary of the Brazilian Unified National Health System (SUS)].

    PubMed

    Paim, Jairnilson Silva

    2013-10-01

    This article, celebrating the 25th anniversary of Brazil's 1988 Constitution, aims to review the country's social policy development, discuss political projects, and analyze challenges for the sustainability of the Unified National Health System (SUS). Based on public policymaking studies, the article revisits the origins of liberal social policy, focused on social assistance, and analyzes the hegemony of U.S. policies targeting poverty and their repercussions for universal policies. After identifying the formulation of political projects in Brazil's democratic transition, it discusses their implications during the various Administrations since 1988, along with the difficulties faced by the National Health System. The article concludes that the political forces occupying government in the last two decades have failed to present a project for the country on the same level as those who drafted the Citizen Constitution. PMID:24127081

  11. The Prospects for Educational Planning. A Workshop Organised by IIEP on the Occasion of Its 25th Anniversary.

    ERIC Educational Resources Information Center

    Caillods, Francoise, Ed.

    In late 1988, on the occasion of its 25th anniversary celebration, the International Institute for Educational Planning organized an international workshop to review the major problems faced by education today and to consider the future of educational planning worldwide. The workshop brought together researchers, planners, and specialists from all…

  12. Highlights of the 25th Anniversary EANM Congress Milan 2012: nuclear medicine and molecular imaging at its best.

    PubMed

    Langsteger, Werner; Beheshti, Mohsen

    2013-09-01

    The European Association of Nuclear Medicine (EANM) celebrated its 25th Anniversary Congress in Milan under the chairmanship of Professor Emilio Bombardieri and the auspices of the Italian Society of Nuclear Medicine. As always, the Congress was a great success: more than 5,530 participants from 88 countries came from Europe and beyond. In spite of limited budgets, industry again made an important contribution: New innovative equipment and tracers demonstrating the latest technology and innovations were presented by 122 companies. This review is a brief summary of the major scientific contributions made in the fields of oncology, multimodality imaging, cardiovascular science, neurology and psychiatry, technological innovation and novel tracers, and in other clinical sciences as well as in radionuclide therapy, which all show promising and great innovations. PMID:23917722

  13. Marshall Space Flight Center 1960-1985: 25th anniversary report

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The Marshall Space FLight Center marks its 25th aniversary with a record of notable achievements. These accomplishments are the essence of the Marshall Center's history. Behind the scenes of the space launches and missions, however, lies the story of challenges faced and problems solved. The highlights of that story are presented. The story is organized not as a straight chronology but as three parallel reviews of the major assignments: propulsion systems and launch vehicles, space science research and technology, and manned space systems. The general goals were to reach space, to know and understand the space environment, and to inhabit and utilize space for the benefit of mankind. Also included is a chronology of major events, presented as a fold-out chart for ready reference.

  14. The MetLife Survey of the American Teacher: Past, Present and Future. A Survey of Teachers, Principals and Students. 25th Anniversary Edition

    ERIC Educational Resources Information Center

    MetLife, Inc., 2008

    2008-01-01

    This report is the twenty-fifth in a series of surveys sponsored annually by MetLife since 1984 as a public service. This 25th anniversary edition includes the views of teachers, principals and students and looks back to the earliest MetLife Surveys to examine how perspectives on teachers, teaching and public education have changed. It documents…

  15. Informing Policy and Practice in Australia's Vocational Education and Training Sector: Reflections and Futures. Proceedings of the 25th Anniversary Forum of the National Centre for Vocational Education Research (Adelaide, South Australia, Australia, March 21, 2007)

    ERIC Educational Resources Information Center

    Curtin, Penelope, Ed.; Loveder, Phil, Ed.

    2007-01-01

    To mark the occasion of its 25th anniversary, the National Centre for Vocational Education Research (NCVER) brought together policy, industry and academic leaders to reflect on the role that research and statistics have played in the development of Australia's vocational education and training (VET) sector. This publication includes the original…

  16. Children's Rights and School Psychology: An Introduction to the Multiple Journal Series Honoring the 25th Anniversary of the United Nations Convention on the Rights of the Child

    ERIC Educational Resources Information Center

    Mcloughlin, Caven S.; Hart, Stuart N.

    2014-01-01

    This year, 2014, is the 25th anniversary of the United Nations Convention on the Rights of the Child--the world's "positive ideology" and its clearest statement of commitments to and respect and aspirations for the dignity of the child. To commemorate this landmark, a program of articles by respected experts has been organized to…

  17. Proceedings of the Anniversary Meeting (25th, Toronto, December 28-29, 1972). Industrial Relations Research Association Series. Index of IRRA Publications 1966-1972.

    ERIC Educational Resources Information Center

    Somers, Gerald G., Ed.

    Papers presented at the 25th meeting of the Industrial Relations Research Association (IRAA) covered issues that are central to industrial relations in North America. Papers and discussions dealt with these major issues: (1) Prices and Income Policy: Comparative Aspects, (2) Dispute Settlement in the Public Sector, (3) Manpower Policies in Canada…

  18. 25th Anniversary Article: Supramolecular Materials for Regenerative Medicine

    PubMed Central

    Boekhoven, Job

    2014-01-01

    In supramolecular materials, molecular building blocks are designed to interact with one another via non-covalent interactions in order to create function. This offers the opportunity to create structures similar to those found in living systems that combine order and dynamics through the reversibility of intermolecular bonds. For regenerative medicine there is a great need to develop materials that signal cells effectively, deliver or bind bioactive agents in vivo at controlled rates, have highly tunable mechanical properties, but at the same time, can biodegrade safely and rapidly after fulfilling their function. These requirements make supramolecular materials a great platform to develop regenerative therapies. This review illustrates the emerging science of these materials and their use in a number of applications for regenerative medicine. PMID:24496667

  19. Naval Training Device Center 25th Anniversary Commemorative Technical Journal.

    ERIC Educational Resources Information Center

    Amico, G. Vincent; Regan, James J.

    Both the technical history of training devices and the issues which currently confront their design and use are discussed by a group of distinguished scientists and engineers. A blend of human factors and engineering paper reflects the twin thrusts that make up the educational tools that are training device systems. (Author)

  20. Apollo-11 25th Arniversary celebration: Space Shuttle Main Engine - Technology Test Bed (SSME-TTB)

    NASA Technical Reports Server (NTRS)

    1994-01-01

    On the 25th Anniversary of the Apollo-11 space launch, Marshall celebrated with a test firing of the Space Shuttle Main Engine at the Technology Test Bed (SSME-TTB). This drew a large crowd who stood in the fields around the test site and watched as plumes of white smoke verified ignition.

  1. EDITORIAL: Inverse Problems' 25th year of publication Inverse Problems' 25th year of publication

    NASA Astrophysics Data System (ADS)

    2008-01-01

    2009 is Inverse Problems' 25th year of publication. In this quarter-century, the journal has established itself as the premier publication venue for inverse problems research. It has matured from its beginnings as a niche journal serving the emerging field of inverse and ill-posed problems to a monthly publication in 2009 covering all aspects of a well-established, vibrant and still-expanding subject. Along with its core readership of pure and applied mathematicians and physicists, Inverse Problems has become widely known across a broad range of researchers in areas such as geophysics, optics, radar, acoustics, communication theory, signal processing and medical imaging, amongst others. The journal's appeal to the inverse problems community and those researchers from the varied fields that encounter such problems can be attributed to our commitment to publishing only the very best papers, and to offering unique services to the community. Besides our regular research papers, which average a remarkably short five months from submission to electronic publication, we regularly publish heavily cited topical review papers and topic-specific special sections, which first appeared in 2004. These highly-downloaded invited articles focus on the latest developments and hot topics in all areas of inverse problems. No other journal in the field offers these features. I am very pleased to take Inverse Problems into its 25th year as Editor-in-Chief. The journal has an impressive tradition of scholarship, established at its inception by the founder and first Editor-in-Chief, Professor Pierre Sabatier. Professor Sabatier envisioned the journal in 1985 as providing a medium for publication of exemplary research in our intrinsically interdisciplinary field. I am glad to say that the support of our authors, readers, referees, Editors-in-Chief, Editorial Boards and Advisory Panels over the years, has resulted in Inverse Problems becoming the top publication in this field, publishing

  2. Introductory address by Dr Demissie Habte on the occasion of the 25th anniversary of ORS.

    PubMed

    Habte, D

    1994-01-01

    In Bangladesh, the director of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B) gave the introductory address at an awards ceremony to celebrate its key role in the discovery of oral rehydration solution (ORS) 25 years ago. ORS, a simple and affordable treatment for diarrheal disease, has specific amounts of glucose, salts, and water. Oral rehydration therapy (ORT) includes ORS and other solutions made with effective and safe salt concentrations and cereals. In South Asia, rock salt with cooked rice in a thick gruel was used to treat diarrhea as long as 3000 years ago. Researchers at the Cholera Research Laboratory in Dhaka during 1964-1968 learned that adding glucose to a solution of salts greatly helps the intestine's ability to absorb water and electrolytes, and that the intestine could absorb them during acute diarrhea. In November, 1987, the researchers set up a large scale field treatment center at a hospital in Malumghat, between Cox's Bazaar and Chittagong. It treated more than 300 cholera patients. No one died, but the trial was a failure. The researchers designed another clinical trial which showed that ORS reduced the need for intravenous fluids by 75% when treating acute cholera in adults. Another ORS trial in Calcutta yielded the same results. The laboratory also showed that ORS alone could rehydrate people with acute dehydrating diarrhea and that medical auxiliaries could administer it. In 1971, ORS successfully treated Bangladeshi refugees with cholera. The international health community officially accepted ORT in 1978. In developed countries, the potential health care cost savings of ORS use is greater than a few billion dollars at the very least and US$ 10-15 billion from optimal ORS use. Government officials from what is now Bangladesh and the US established the Cholera Research Laboratory 32 years ago. 18 years later, it became ICDDR,B. We must recognize the miracle of ORS. PMID:12345476

  3. 25th anniversary of the deep manned submersibles Mir- 1 and Mir- 2

    NASA Astrophysics Data System (ADS)

    Sagalevitch, A. M.

    2012-11-01

    In 1987, the deep manned submersibles Mir- 1 and Mir- 2 were introduced into the practice of scientific research of the ocean. For 25 years, with their help, a wide range of deepwater operations have been carried out: oceanic scientific research (including the most active areas on the seabed—hydrothermal fields), shooting films and documentaries, which have brought international fame to the vehicles; special operations concerning solving problems of national importance concerning the sunken nuclear submarines Komsomolets and Kursk; live television broadcast from great depths of the ocean via satellite to the earth; diving under the ice at the geographic North Pole; a three-year cycle of scientific research on lake Baikal; etc. During the 25 years of their operation, there have been no unsolvable problems in the deep ocean for the Mir vehicles. They have rightfully taken a leading position in the field of deep-sea research in the world and were named the best vehicles in technical terms in the history of the creation of such technical facilities. Some of the results and details of the above-mentioned deep-sea operations, as well as the technical innovations developed and implemented during the service of the Mir vehicles, are considered in this article.

  4. A resolution recognizing the 25th anniversary of the Chernobyl nuclear disaster.

    THOMAS, 112th Congress

    Sen. Lugar, Richard G. [R-IN

    2011-04-14

    05/09/2011 Resolution agreed to in Senate with an amendment and with a preamble by Unanimous Consent. (text: CR S2799) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  5. 25th anniversary article: semiconductor nanowires--synthesis, characterization, and applications.

    PubMed

    Dasgupta, Neil P; Sun, Jianwei; Liu, Chong; Brittman, Sarah; Andrews, Sean C; Lim, Jongwoo; Gao, Hanwei; Yan, Ruoxue; Yang, Peidong

    2014-04-01

    Semiconductor nanowires (NWs) have been studied extensively for over two decades for their novel electronic, photonic, thermal, electrochemical and mechanical properties. This comprehensive review article summarizes major advances in the synthesis, characterization, and application of these materials in the past decade. Developments in the understanding of the fundamental principles of "bottom-up" growth mechanisms are presented, with an emphasis on rational control of the morphology, stoichiometry, and crystal structure of the materials. This is followed by a discussion of the application of nanowires in i) electronic, ii) sensor, iii) photonic, iv) thermoelectric, v) photovoltaic, vi) photoelectrochemical, vii) battery, viii) mechanical, and ix) biological applications. Throughout the discussion, a detailed explanation of the unique properties associated with the one-dimensional nanowire geometry will be presented, and the benefits of these properties for the various applications will be highlighted. The review concludes with a brief perspective on future research directions, and remaining barriers which must be overcome for the successful commercial application of these technologies. PMID:24604701

  6. Development and External Debt: Friend or Foe? Academy for Educational Development 25th Anniversary Seminar Series.

    ERIC Educational Resources Information Center

    Hope, Nicholas C.

    Arguing that the benefits from borrowing abroad exceed the costs recently imposed on countries through debt-servicing difficulties, this paper defines debt as an engine of growth, forcing the borrower to produce goods efficiently, export them, and function competitively in the international market. Debt-servicing difficulties of developing nations…

  7. A resolution honoring the Blackstone Valley Tourism Council on the celebration of its 25th anniversary.

    THOMAS, 111th Congress

    Sen. Whitehouse, Sheldon [D-RI

    2010-03-24

    04/14/2010 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (text: CR S2326) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  8. AIDS: The Global Impact. Academy for Educational Development 25th Anniversary Seminar Series.

    ERIC Educational Resources Information Center

    Mann, Jonathan

    This paper describes why acquired immune deficiency syndrome (AIDS) is a global health problem and discusses special features of the virus and its infection. This disease's transmission and interaction with other diseases, along with 1986 statistics concerning AIDS, are presented in terms of selected continents and countries. The World Health…

  9. 25th Anniversary Article: A Soft Future: From Robots and Sensor Skin to Energy Harvesters

    PubMed Central

    Bauer, Siegfried; Bauer-Gogonea, Simona; Graz, Ingrid; Kaltenbrunner, Martin; Keplinger, Christoph; Schwödiauer, Reinhard

    2014-01-01

    Scientists are exploring elastic and soft forms of robots, electronic skin and energy harvesters, dreaming to mimic nature and to enable novel applications in wide fields, from consumer and mobile appliances to biomedical systems, sports and healthcare. All conceivable classes of materials with a wide range of mechanical, physical and chemical properties are employed, from liquids and gels to organic and inorganic solids. Functionalities never seen before are achieved. In this review we discuss soft robots which allow actuation with several degrees of freedom. We show that different actuation mechanisms lead to similar actuators, capable of complex and smooth movements in 3d space. We introduce latest research examples in sensor skin development and discuss ultraflexible electronic circuits, light emitting diodes and solar cells as examples. Additional functionalities of sensor skin, such as visual sensors inspired by animal eyes, camouflage, self-cleaning and healing and on-skin energy storage and generation are briefly reviewed. Finally, we discuss a paradigm change in energy harvesting, away from hard energy generators to soft ones based on dielectric elastomers. Such systems are shown to work with high energy of conversion, making them potentially interesting for harvesting mechanical energy from human gait, winds and ocean waves. PMID:24307641

  10. 25th anniversary article: A soft future: from robots and sensor skin to energy harvesters.

    PubMed

    Bauer, Siegfried; Bauer-Gogonea, Simona; Graz, Ingrid; Kaltenbrunner, Martin; Keplinger, Christoph; Schwödiauer, Reinhard

    2014-01-01

    Scientists are exploring elastic and soft forms of robots, electronic skin and energy harvesters, dreaming to mimic nature and to enable novel applications in wide fields, from consumer and mobile appliances to biomedical systems, sports and healthcare. All conceivable classes of materials with a wide range of mechanical, physical and chemical properties are employed, from liquids and gels to organic and inorganic solids. Functionalities never seen before are achieved. In this review we discuss soft robots which allow actuation with several degrees of freedom. We show that different actuation mechanisms lead to similar actuators, capable of complex and smooth movements in 3d space. We introduce latest research examples in sensor skin development and discuss ultraflexible electronic circuits, light emitting diodes and solar cells as examples. Additional functionalities of sensor skin, such as visual sensors inspired by animal eyes, camouflage, self-cleaning and healing and on-skin energy storage and generation are briefly reviewed. Finally, we discuss a paradigm change in energy harvesting, away from hard energy generators to soft ones based on dielectric elastomers. Such systems are shown to work with high energy of conversion, making them potentially interesting for harvesting mechanical energy from human gait, winds and ocean waves. PMID:24307641

  11. 25th anniversary article: Rise to power--OPV-based solar parks.

    PubMed

    Krebs, Frederik C; Espinosa, Nieves; Hösel, Markus; Søndergaard, Roar R; Jørgensen, Mikkel

    2014-01-01

    A solar park based on polymer solar cells is described and analyzed with respect to performance, practicality, installation speed, and energy payback time. It is found that a high voltage installation where solar cells are all printed in series enables an installation rate in Watts installed per minute that far exceed any other PV technology in existence. The energy payback time for the practical installation of polymer solar cell foil on a wooden 250 square meter platform in its present form is 277 days when operated in Denmark and 180 days when operated in southern Spain. The installation and de-installation rate is above 100 m min⁻¹, which, with the present performance and web width, implies installation of >200 W min⁻¹. In comparison, this also exceeds the overall manufacturing speed of the polymer solar cell foil with a width of 305 mm which is currently 1 m min⁻¹ for complete encapsulated and tested foil. It is also significant that simultaneous installation and de-installation which enables efficient schemes for decommissioning and recycling is possible. It is highlighted where research efforts should most rationally be invested in order to make grid electricity from OPV a reality (and it is within reach). PMID:24741693

  12. 25th anniversary article: label-free electrical biodetection using carbon nanostructures.

    PubMed

    Balasubramanian, Kannan; Kern, Klaus

    2014-02-26

    Nanostructures are promising candidates for use as active materials for the detection of chemical and biological species, mainly due to the high surface-to-volume ratio and the unique physical properties arising at the nanoscale. Among the various nanostructures, materials comprised of sp(2) -carbon enjoy a unique position due to the possibility to readily prepare them in various dimensions ranging from 0D, through 1D to 2D. This review focuses on the use of 1D (carbon nanotubes) and 2D (graphene) carbon nanostructures for the detection of biologically relevant molecules. A key advantage is the possibility to perform the sensing operation without the use of any labels or complex reaction schemes. Along this spirit, various strategies reported for the label-free electrical detection of biomolecules using carbon nanostructures are discussed. With their promise for ultimate sensitivity and the capability to attain high selectivity through controlled chemical functionalization, carbon-based nanobiosensors are expected to open avenues to novel diagnostic tools as well as to obtain new fundamental insight into biomolecular interactions down to the single molecule level. PMID:24452968

  13. 25th anniversary article: polymer-particle composites: phase stability and applications in electrochemical energy storage.

    PubMed

    Srivastava, Samanvaya; Schaefer, Jennifer L; Yang, Zichao; Tu, Zhengyuan; Archer, Lynden A

    2014-01-15

    Polymer-particle composites are used in virtually every field of technology. When the particles approach nanometer dimensions, large interfacial regions are created. In favorable situations, the spatial distribution of these interfaces can be controlled to create new hybrid materials with physical and transport properties inaccessible in their constituents or poorly prepared mixtures. This review surveys progress in the last decade in understanding phase behavior, structure, and properties of nanoparticle-polymer composites. The review takes a decidedly polymers perspective and explores how physical and chemical approaches may be employed to create hybrids with controlled distribution of particles. Applications are studied in two contexts of contemporary interest: battery electrolytes and electrodes. In the former, the role of dispersed and aggregated particles on ion-transport is considered. In the latter, the polymer is employed in such small quantities that it has been historically given titles such as binder and carbon precursor that underscore its perceived secondary role. Considering the myriad functions the binder plays in an electrode, it is surprising that highly filled composites have not received more attention. Opportunities in this and related areas are highlighted where recent advances in synthesis and polymer science are inspiring new approaches, and where newcomers to the field could make important contributions. PMID:24323839

  14. Cartography and Connectomes Perspective article for Neuron 25th Anniversary Issue

    PubMed Central

    Van Essen, David C.

    2013-01-01

    The past 25 years have seen great progress in parcellating the cerebral cortex into a mosaic of many distinct areas in mice, monkeys, and humans. Quantitative studies of inter-areal connectivity have revealed unexpectedly many pathways and a wide range of connection strengths in mouse and macaque cortex. In humans, advances in analyzing ‘structural’ and ‘functional’ connectivity using powerful but indirect noninvasive neuroimaging methods are yielding intriguing insights about brain circuits, their variability across individuals, and their relationship to behavior. PMID:24183027

  15. National Center for Biotechnology Information Celebrates 25th Anniversary | NIH MedlinePlus the Magazine

    MedlinePlus

    ... http://m.medlineplus.gov/spanish Tune in: NIH Radio Free podcast audio reports on your computer or personal audio player www.nih.gov/news/radio/nihpodcast.htm Winter 2014 Issue: Volume 8 Number ...

  16. [To the 25th anniversary of commencement of perestroika of national public health].

    PubMed

    Juravleva, T V; Khmel, A A

    2012-01-01

    The process of modernization of public health of the Russian Federation requires the application of experience of resent past. In 2012, is 25 years from the day of approval of the decree "The main directions of development of population health protection and perestroika of public health of the USSR in 12th five-year plan and to the period up to 2000". Many items of this document remained unrealized due to the change of social political course of country progression. Nevertheless, these items can be used presently to enhance the legislation in public health sector. PMID:23634616

  17. 25th anniversary article: carbon nanotube- and graphene-based transparent conductive films for optoelectronic devices.

    PubMed

    Du, Jinhong; Pei, Songfeng; Ma, Laipeng; Cheng, Hui-Ming

    2014-04-01

    Carbon nanotube (CNT)- and graphene (G)-based transparent conductive films (TCFs) are two promising alternatives for commonly-used indium tin oxide-based TCFs for future flexible optoelectronic devices. This review comprehensively summarizes recent progress in the fabrication, properties, modification, patterning, and integration of CNT- and G-TCFs into optoelectronic devices. Their potential applications and challenges in optoelectronic devices, such as organic photovoltaic cells, organic light emitting diodes and touch panels, are discussed in detail. More importantly, their key characteristics and advantages for use in these devices are compared. Despite many challenges, CNT- and G-TCFs have demonstrated great potential in various optoelectronic devices and have already been used for some products like touch panels of smartphones. This illustrates the significant opportunities for the industrial use of CNTs and graphene, and hence pushes nanoscience and nanotechnology one step towards practical applications. PMID:24591083

  18. The Hawaii Undersea Research Laboratory's 25th Anniversary Expedition to the South Pacific

    NASA Astrophysics Data System (ADS)

    Smith, J. R.; Wiltshire, J. C.; Malahoff, A.

    2005-12-01

    The Hawaii Undersea Research Laboratory (HURL) was established by NOAA at the University of Hawaii 25 years ago as part of its National Undersea Research Program. HURL's mission is to study deep water marine processes in the Pacific Ocean through a competitive proposal and review process. The dual Pisces IV and Pisces V 2000-meter manned submersibles, an RCV-150 1000-meter ROV, and multibeam equipped support ship R/V Ka'imikai-o-Kanaloa ( KoK) were largely acquired from the petroleum industry then adapted and upgraded to carry out cutting edge scientific expeditions. These studies range from active submarine volcanoes, delicate precious coral gardens, endangered marine mammal and fisheries management, to engineering surveys and deployment of observatory systems. HURL successfully completed a major 5-month expedition to the South Pacific during March-August 2005, working in the waters of New Zealand, Tonga, American Samoa, and the U.S. Line Islands covering a distance of nearly 14,500 nautical miles. This mission was significant in both the scientific merit and scope of operations, consisting of 8 different cruise legs at 21 study sites, with 12 chief and co-chief scientists, 58 total science team participants, and completing 61 out of 56 scheduled Pisces science dives, 17 ROV dives, 5 multibeam survey areas, 6 CTD rosette deployments, and 7 instrument mooring recoveries. The $3.5 million expedition was funded by an international partnership with New Zealand agencies (GNS & NIWA) and the University of Kiel in Germany along with the NOAA Office of Exploration and National Undersea Research Program. While most of the individual cruise legs focused on active submarine volcanoes of the Tonga-Kermadec Islands Arc and the Samoan hot spot chain with their hydrothermal systems and associated biological communities, others concentrated on marine protected areas including those of American Samoa and the remote atolls of the Line Islands of the Central Pacific. These studies included biological habitat mapping, climate change from dating of precious coral growth rings, ecological inventory assessments, and the marine archeology and impact from a grounded vessel. An overview of the latter portion of the voyage will be presented, along with the general capabilities of the HURL systems, and how they may be utilized by others employing the international collaborative model for extended missions to remote locations in the pursuit of deep submergence science.

  19. 25th Anniversary Article: Organic Field-Effect Transistors: The Path Beyond Amorphous Silicon

    PubMed Central

    Sirringhaus, Henning

    2014-01-01

    Over the past 25 years, organic field-effect transistors (OFETs) have witnessed impressive improvements in materials performance by 3–4 orders of magnitude, and many of the key materials discoveries have been published in Advanced Materials. This includes some of the most recent demonstrations of organic field-effect transistors with performance that clearly exceeds that of benchmark amorphous silicon-based devices. In this article, state-of-the-art in OFETs are reviewed in light of requirements for demanding future applications, in particular active-matrix addressing for flexible organic light-emitting diode (OLED) displays. An overview is provided over both small molecule and conjugated polymer materials for which field-effect mobilities exceeding > 1 cm2 V–1 s–1 have been reported. Current understanding is also reviewed of their charge transport physics that allows reaching such unexpectedly high mobilities in these weakly van der Waals bonded and structurally comparatively disordered materials with a view towards understanding the potential for further improvement in performance in the future. PMID:24443057

  20. 1984-2008. Predictions for Higher Education. From the 25th Anniversary Colloquium. [Proceedings].

    ERIC Educational Resources Information Center

    Hardee, Melvene Draheim, Ed.

    Predictions on higher education for 1984-2009 are presented in the proceedings of a colloquium of the Institute for Studies in Higher Education of Florida State University. Presentations were made at the colloquium by 10 graduates of the university whose current positions represent administration-management, instruction, research, and student…

  1. 25th Anniversary Article: Ordered Polymer Structures for the Engineering of Photons and Phonons

    PubMed Central

    Lee, Jae-Hwang; Koh, Cheong Yang; Singer, Jonathan P; Jeon, Seog-Jin; Maldovan, Martin; Stein, Ori; Thomas, Edwin L

    2014-01-01

    The engineering of optical and acoustic material functionalities via construction of ordered local and global architectures on various length scales commensurate with and well below the characteristic length scales of photons and phonons in the material is an indispensable and powerful means to develop novel materials. In the current mature status of photonics, polymers hold a pivotal role in various application areas such as light-emission, sensing, energy, and displays, with exclusive advantages despite their relatively low dielectric constants. Moreover, in the nascent field of phononics, polymers are expected to be a superior material platform due to the ability for readily fabricated complex polymer structures possessing a wide range of mechanical behaviors, complete phononic bandgaps, and resonant architectures. In this review, polymer-centric photonic and phononic crystals and metamaterials are highlighted, and basic concepts, fabrication techniques, selected functional polymers, applications, and emerging ideas are introduced. PMID:24338738

  2. Newspapers on Microfilm. Catalog and Price List 1971, 25th Anniversary Edition.

    ERIC Educational Resources Information Center

    1971

    Over 5500 current and backfile titles of American, foreign, and Black community newspapers that may be purchased on 35mm. roll microfilm are indexed in this catalog. Historical annotations are provided for selected American, Asian, and other foreign newspapers as well as for collections which focus on areas of special interest: early America, the…

  3. 25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine

    PubMed Central

    Annabi, Nasim; Tamayol, Ali; Uquillas, Jorge Alfredo; Akbari, Mohsen; Bertassoni, Luiz E.; Cha, Chaenyung; Camci-Unal, Gulden; Dokmeci, Mehmet R.

    2014-01-01

    Hydrogels are hydrophilic polymer-based materials with high water content and physical characteristics that resemble the native extracellular matrix. Because of their remarkable properties, hydrogel systems are used for a wide range of biomedical applications, such as three-dimensional (3D) matrices for tissue engineering, drug-delivery vehicles, composite biomaterials, and as injectable fillers in minimally invasive surgeries. In addition, the rational design of hydrogels with controlled physical and biological properties can be used to modulate cellular functionality and tissue morphogenesis. Here, the development of advanced hydrogels with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light-sensitive, composite, and shape-memory hydrogels. Emerging technologies developed over the past decade to control hydrogel architecture are also discussed and a number of potential applications and challenges in the utilization of hydrogels in regenerative medicine are reviewed. It is anticipated that the continued development of sophisticated hydrogels will result in clinical applications that will improve patient care and quality of life. PMID:24741694

  4. 25th anniversary article: key points for high-mobility organic field-effect transistors.

    PubMed

    Dong, Huanli; Fu, Xiaolong; Liu, Jie; Wang, Zongrui; Hu, Wenping

    2013-11-20

    Remarkable progress has been made in developing high performance organic field-effect transistors (OFETs) and the mobility of OFETs has been approaching the values of polycrystalline silicon, meeting the requirements of various electronic applications from electronic papers to integrated circuits. In this review, the key points for development of high mobility OFETs are highlighted from aspects of molecular engineering, process engineering and interface engineering. The importance of other factors, such as impurities and testing conditions is also addressed. Finally, the current challenges in this field for practical applications of OFETs are further discussed. PMID:24105677

  5. 25th anniversary article: progress in chemistry and applications of functional indigos for organic electronics.

    PubMed

    Głowacki, Eric Daniel; Voss, Gundula; Sariciftci, Niyazi Serdar

    2013-12-17

    Indigo and its derivatives are dyes and pigments with a long and distinguished history in organic chemistry. Recently, applications of this 'old' structure as a functional organic building block for organic electronics applications have renewed interest in these molecules and their remarkable chemical and physical properties. Natural-origin indigos have been processed in fully bio-compatible field effect transistors, operating with ambipolar mobilities up to 0.5 cm(2) /Vs and air-stability. The synthetic derivative isoindigo has emerged as one of the most successful building-blocks for semiconducting polymers for plastic solar cells with efficiencies > 5%. Another isomer of indigo, epindolidione, has also been shown to be one of the best reported organic transistor materials in terms of mobility (∼2 cm(2) /Vs) and stability. This progress report aims to review very recent applications of indigoids in organic electronics, but especially to logically bridge together the hereto independent research directions on indigo, isoindigo, and other materials inspired by historical dye chemistry: a field which was the root of the development of modern chemistry in the first place. PMID:24151199

  6. 25th anniversary article: CVD polymers: a new paradigm for surface modification and device fabrication.

    PubMed

    Coclite, Anna Maria; Howden, Rachel M; Borrelli, David C; Petruczok, Christy D; Yang, Rong; Yagüe, Jose Luis; Ugur, Asli; Chen, Nan; Lee, Sunghwan; Jo, Won Jun; Liu, Andong; Wang, Xiaoxue; Gleason, Karen K

    2013-10-11

    Well-adhered, conformal, thin (<100 nm) coatings can easily be obtained by chemical vapor deposition (CVD) for a variety of technological applications. Room temperature modification with functional polymers can be achieved on virtually any substrate: organic, inorganic, rigid, flexible, planar, three-dimensional, dense, or porous. In CVD polymerization, the monomer(s) are delivered to the surface through the vapor phase and then undergo simultaneous polymerization and thin film formation. By eliminating the need to dissolve macromolecules, CVD enables insoluble polymers to be coated and prevents solvent damage to the substrate. CVD film growth proceeds from the substrate up, allowing for interfacial engineering, real-time monitoring, and thickness control. Initiated-CVD shows successful results in terms of rationally designed micro- and nanoengineered materials to control molecular interactions at material surfaces. The success of oxidative-CVD is mainly demonstrated for the deposition of organic conducting and semiconducting polymers. PMID:24115244

  7. Literacy: Celebration and Challenge. Illinois Reading Council Silver Anniversary Monograph.

    ERIC Educational Resources Information Center

    Johns, Jerry L., Ed.; And Others

    Celebrating the Illinois Reading Council's 25th anniversary year, this 2-part monograph presents 11 papers on diverse aspects of reading and literacy. Papers in the first part, called "Historical Reflections and Challenges," are: "The Illinois Reading Council Celebrates 25 Years" (John W. Logan); "The 'Illinois Reading Council Journal':…

  8. Graduate Education--Past--Present--Future. Proceedings of the Annual Meeting of the Council of Graduate Schools in the United States (25th, Anaheim, California, December 11-14, 1985).

    ERIC Educational Resources Information Center

    Khalil, Edna M., Ed.

    This proceedings document contains papers presented at the 25th anniversary meeting of the Council of Graduate Schools in the United States (CGS); information on the CGS business meeting, notices of awards presentations, copies of the CGS constitution and bylaws, and a CGS membership list. Topics and presenters are as follows: "Current Issues in…

  9. Neck skin rejuvenation.

    PubMed

    Duplechain, J Kevin

    2014-05-01

    The author of this article uses the pulsed ablative CO2 laser for resurfacing of the neck and face, based on the gold standard status of the CO2 laser and a novel post-treatment plan that greatly reduces adverse effects traditionally associated with fully ablative resurfacing. The croton oil peel is an inexpensive and effective modality for rejuvenating neck skin. The use of either technique as an adjunct to neck lift surgery, with or without facelift surgery, permits surgeons to fulfill the expectations of patients who want the skin of their face and neck to be homogeneous and more attractive. PMID:24745383

  10. Proceedings of the 25th intersociety energy conversion engineering conference

    SciTech Connect

    Nelson, P.A.; Schertz, W.W.; Till, R.H.

    1990-01-01

    This book contains the proceedings of the 25th Intersociety Energy Conversion Engineering Conference. Volume 5 is organized under the following headings: Photovoltaics I, Photovoltaics II, Geothermal power, Thermochemical conversion of biomass, Energy from waste and biomass, Solar thermal systems for environmental applications, Solar thermal low temperature systems and components, Solar thermal high temperature systems and components, Wind systems, Space power sterling technology Stirling cooler developments, Stirling solar terrestrial I, Stirling solar terrestrial II, Stirling engine generator sets, Stirling models and simulations, Stirling engine analysis, Stirling models and simulations, Stirling engine analysis, Stirling engine loss understanding, Novel engine concepts, Coal conversion and utilization, Power cycles, MHD water propulsion I, Underwater vehicle powerplants - performance, MHD underwater propulsion II, Nuclear power, Update of advanced nuclear power reactor concepts.

  11. Witnessing Solar Rejuvenation

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2015-09-01

    At the end of last year, the Suns large-scale magnetic field suddenly strengthened, reaching its highest value in over two decades. Here, Neil Sheeley and Yi-Ming Wang (both of the Naval Research Laboratory) propose an explanation for why this happened and what it predicts for the next solar cycle.Magnetic StrengtheningUntil midway through 2014, solar cycle 24 the current solar cycle was remarkably quiet. Even at its peak, it averaged only 79 sunspots per year, compared to maximums of up to 190 in recent cycles. Thus it was rather surprising when, toward the end of 2014, the Suns large-scale magnetic field underwent a sudden rejuvenation, with its mean field leaping up to its highest values since 1991 and causing unprecedentedly large numbers of coronal loops to collapse inward.Yet in spite of the increase we observed in the Suns open flux (the magnetic flux leaving the Suns atmosphere, measured from Earth), there was not a significant increase in solar activity, as indicated by sunspot number and the rate of coronal mass ejections. This means that the number of sources of magnetic flux didnt increase so Sheeley and Wang conclude that flux must instead have been emerging from those sources in a more efficient way! But how?Aligned ActivityWSO open flux and the radial component of the interplanetary magnetic field (measures of the magnetic flux leaving the Suns photosphere and heliosphere, respectively), compared to sunspot number (in units of 100 sunspots). A sudden increase in flux is visible after the peak of each of the last four sunspot cycles. Click for a larger view! [Sheeley Wang 2015]The authors show that the active regions on the solar surface in late 2014 lined up in such a way that the emerging flux was enhanced, forming a strong equatorial dipole field that accounts for the sudden rejuvenation observed.Interestingly, this rejuvenation of the Suns open flux wasnt just a one-time thing; similar bursts have occurred shortly after the peak of every sunspot

  12. Combination hand rejuvenation procedures.

    PubMed

    Shamban, Ava T

    2009-01-01

    Although the hands age at the same rate as the face, the aging process differs and requires a combination treatment approach for optimal rejuvenation. Photoaging causes epidermal changes such as lentigines, actinic keratoses, fine wrinkles, and crepe-like textural change. Thinning of the dermis and subcutaneous fat occurs as a result of both ultraviolet light exposure and intrinsic aging. This process can lead to a skeletal appearance of the hands, with prominent veins and bulging tendons. The combination approach addresses all of these issues, employing lasers, intense pulsed light devices, fractional devices, fillers, peels, vein sclerotherapy, and an effective at-home skin care program as indicated for individual needs and concerns. PMID:19825471

  13. 25th PolyMAC Conference, June 13-15, 1995

    SciTech Connect

    Smith, P.F.

    1995-06-01

    This document contains abstracts of reports presented at the 25th Annual Polymeric, Materials, Adhesives and Composites Symposium. Reports covered aging, testing and performance, and encapsulating materials.

  14. Rejuvenation of spiral bulges

    NASA Astrophysics Data System (ADS)

    Thomas, Daniel; Davies, Roger L.

    2006-02-01

    We seek to understand whether the stellar populations of galactic bulges show evidence of secular evolution triggered by the presence of the disc. For this purpose, we re-analyse the sample of Proctor and Sansom, deriving stellar population ages and element abundances from absorption-line indices as functions of central velocity dispersion and Hubble type. We obtain consistent constraints on ages from the three Balmer-line indices Hβ, Hγ and Hδ, based on stellar population models that take the abundance ratio effects on these indices into account. Emission-line contamination turns out to be a critical aspect, which favours the use of the higher order Balmer-line indices. Our derived ages are consistent with those of Proctor and Sansom based on a completely different method. In agreement with other studies in the literature, we find that bulges have relatively low luminosity weighted ages, the lowest age derived being 1.3Gyr. Hence, bulges are not generally old, but actually rejuvenated systems. We discuss evidence that this might be true also for the bulge of the Milky Way. The data reveal clear correlations of all three parameters luminosity weighted age, total metallicity and α/Fe ratio with central velocity dispersion. The smallest bulges are the youngest with the lowest α/Fe ratios owing to late Fe enrichment from Type Ia supernovae. Using models combining recent minor star formation with a base old population, we show that the smallest bulges must have experienced significant star formation events involving 10-30 per cent of their total mass in the past 1-2Gyr. No significant correlations of the stellar population parameters with Hubble type are found. We show that the above relationships with σ coincide perfectly with those of early-type galaxies. In other words, bulges are typically younger, metal poorer and less α/Fe enhanced than early-type galaxies because of their smaller masses. At a given velocity dispersion, bulges and elliptical galaxies are

  15. Proceedings of the 25th Himalaya-Karakoram-Tibet Workshop

    USGS Publications Warehouse

    Leech, Mary L.; Klemperer, Simon L.; Mooney, Walter D.

    2010-01-01

    For a quarter of a century the Himalayan-Karakoram-Tibet (HKT) Workshop has provided scientists studying the India-Asia collision system a wonderful opportunity for workshop-style discussion with colleagues working in this region. In 2010, HKT returns to North America for the first time since 1996. The 25th international workshop is held from June 7 to10 at San Francisco State University, California. The international community was invited to contribute scientific papers to the workshop, on all aspects of geoscience research in the geographic area of the Tibetan Plateau and its bounding ranges and basins, from basic mapping to geochemical and isotopic analyses to large-scale geophysical imaging experiments. In recognition of the involvement of U.S. Geological Survey (USGS) scientists in a wide range of these activities, the USGS agreed to publish the extended abstracts of the numerous components of HKT-25 as an online Open-File Report, thereby ensuring the wide availability and distribution of these abstracts, particularly in the HKT countries from which many active workers are precluded by cost from attending international meetings. In addition to the workshop characterized by contributed presentations, participants were invited to attend a pre-meeting field trip from the Coast Ranges to the Sierra Nevada, to allow the international group to consider how the tectonic elements of the Pacific margin compare to those of the Himalayan belt. Following the workshop, the National Science Foundation (NSF) sponsored a workshop on the 'Future directions for NSF-sponsored geoscience research in the Himalaya/Tibet' intended to provide NSF Program Directors with a clear statement and vision of community goals for the future, including the scientific progress we can expect if NSF continues its support of projects in this geographic region, and to identify which key geoscience problems and processes are best addressed in the Himalaya and Tibet, what key datasets are needed, and

  16. 25th anniversary article: Design of polymethine dyes for all-optical switching applications: guidance from theoretical and computational studies.

    PubMed

    Gieseking, Rebecca L; Mukhopadhyay, Sukrit; Risko, Chad; Marder, Seth R; Brédas, Jean-Luc

    2014-01-01

    All-optical switching--controlling light with light--has the potential to meet the ever-increasing demand for data transmission bandwidth. The development of organic π-conjugated molecular materials with the requisite properties for all-optical switching applications has long proven to be a significant challenge. However, recent advances demonstrate that polymethine dyes have the potential to meet the necessary requirements. In this review, we explore the theoretical underpinnings that guide the design of π-conjugated materials for all-optical switching applications. We underline, from a computational chemistry standpoint, the relationships among chemical structure, electronic structure, and optical properties that make polymethines such promising materials. PMID:24302357

  17. Education, Section J. Extracted from the 2000 New York State Statistical Yearbook. 25th Anniversary Edition. Revised and Expanded.

    ERIC Educational Resources Information Center

    State Univ. of New York, Albany. Nelson A. Rockefeller Inst. of Government.

    This yearbook presents statistical information about the state of New York and its population as well as information on the five boroughs of New York City. The 41 tables of Section J describe education in New York state in the 1990s and into 2000 and contain information that makes it possible to compare these statistics from previous years and for…

  18. The Anesthesia Patient Safety Foundation at 25: a pioneering success in safety, 25th anniversary provokes reflection, anticipation.

    PubMed

    Eichhorn, John H

    2012-04-01

    The Anesthesia Patient Safety Foundation (APSF) was created in 1985. Its founders coined the term "patient safety" in its modern public usage and created the very first patient safety organization, igniting a movement that is now universal in all of health care. Driven by the vision "that no patient shall be harmed by anesthesia," the APSF has worked tirelessly for more than a quarter century to promote safety education and communication through its widely read Newsletter, its programs, and its presentations. The APSF's extensive research grant program has supported a great many projects leading to key safety improvements and, in particular, was central in the development of high-fidelity mannequin simulation as a research and teaching tool. With its pioneering collaboration, the APSF is unique in incorporating the talents and resources of anesthesia professionals of all types, safety scientists, pharmaceutical and equipment manufacturers, regulators, liability insurance companies, and also surgeons. Specific alerts, campaigns, discussions, and projects have targeted a host of safety issues and dangers over the years, starting with minimal intraoperative monitoring in 1986 and all the way up to beach-chair position cerebral perfusion pressure, operating room medication errors, and the extremely popular DVD on operating room fire safety in 2010; the list is long and expansive. The APSF has served as a model and inspiration for subsequent patient safety organizations and has been recognized nationally as having a dramatic positive impact on the safety of anesthesia care. Recognizing that the work is not over, that systems, organizations, and equipment still at times fail, that basic preventable human errors still do sometimes occur, and that "production pressure" in anesthesia practice threatens past safety gains, the APSF is firmly committed and continues to work hard both on established tenets and new patient safety principles. PMID:22253277

  19. Biotechnology and the Third World: Panacea or Recipe for Social Disaster? Academy for Educational Development 25th Anniversary Series.

    ERIC Educational Resources Information Center

    Morehouse, Ward

    Asserting that developmental growth is easier to attain in developing countries than social change, this paper assesses the prospective impact of biotechnology on the developing nations. Biotechnology is defined as the integrated use of biochemistry, microbiology, and chemical engineering to achieve the industrial processes of fermentation, enzyme…

  20. 25th anniversary article: The evolution of electronic skin (e-skin): a brief history, design considerations, and recent progress.

    PubMed

    Hammock, Mallory L; Chortos, Alex; Tee, Benjamin C-K; Tok, Jeffrey B-H; Bao, Zhenan

    2013-11-13

    Human skin is a remarkable organ. It consists of an integrated, stretchable network of sensors that relay information about tactile and thermal stimuli to the brain, allowing us to maneuver within our environment safely and effectively. Interest in large-area networks of electronic devices inspired by human skin is motivated by the promise of creating autonomous intelligent robots and biomimetic prosthetics, among other applications. The development of electronic networks comprised of flexible, stretchable, and robust devices that are compatible with large-area implementation and integrated with multiple functionalities is a testament to the progress in developing an electronic skin (e-skin) akin to human skin. E-skins are already capable of providing augmented performance over their organic counterpart, both in superior spatial resolution and thermal sensitivity. They could be further improved through the incorporation of additional functionalities (e.g., chemical and biological sensing) and desired properties (e.g., biodegradability and self-powering). Continued rapid progress in this area is promising for the development of a fully integrated e-skin in the near future. PMID:24151185

  1. The Role of SoTL in the Academy: Upon the 25th Anniversary of Boyer's "Scholarship Reconsidered"

    ERIC Educational Resources Information Center

    Kern, Beth; Mettetal, Gwendolyn; Dixson, Marcia D.; Morgan, Robin K.

    2015-01-01

    In this essay, we explore definitions and taxonomies of the Scholarship of Teaching and Learning (SoTL) and present a model of the Dimensions of Activities Related to Teaching (DART) which provides a context for SoTL along two dimensions: public/private and systematic/informal. The four quadrants: practice of teaching, sharing about teaching,…

  2. A resolution celebrating February 2, 2011, as the 25th anniversary of "National Women and Girls in Sports Day".

    THOMAS, 112th Congress

    Sen. Snowe, Olympia J. [R-ME

    2011-01-27

    02/02/2011 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (text: CR S492) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  3. Proceedings of the 25th Annual Stirling Physics Meeting 1999

    NASA Astrophysics Data System (ADS)

    McVey, Michael

    1999-09-01

    The 25th Annual Stirling Physics meeting took place on Thursday 20 May on a warm sunny day when the country setting of Stirling Campus could be seen at its best. A total of 225 participants from all sectors of physics education attended. There was an opportunity to view and discuss with exhibitors a wide range of state-of-the-art equipment and teaching materials both before and after the meeting. The theme of the meeting was `Maintaining Standards'. Gemmel Millar, Scottish Branch Secretary acting as Chairperson for the morning session and in anticipation of the first speaker, wondered if a new unit qualification, the `Planck' might be introduced. Half units would then be `Short Plancks' and how many Short Plancks must there be in a unit? Great stuff. Scottish Qualifications Authority Hugh McGill began with a brief history and description of the Scottish Qualifications Authority. Born on 1 April 1997 (a light frisson of amusement swept through the audience) it was a unification between SEB and SCOTVEC and has a range of responsibilities covering schools, further and higher education. It oversees Standard and Higher grades, HNC and HND and SVQs, and it has 500 full-time employees as well as some 13500 appointees who act as examiners, assessors and verifiers etc, without whom its remit could not be carried out. The committee structure of the Board was outlined, one each for national and higher national qualifications and a third for Scottish vocational qualifications. These will be served by a proposed 19 Advisory Groups. The Science Advisory Group will be the key body for advising SQA on strategic developments to ensure that qualifications meet the needs of both client groups and end users. A consultation paper `Added Value To Learning' was referred to, in which all qualifications available in Scotland are given parity of esteem on a rising 11-point scale. Mr McGill stated that standards would be best maintained by ensuring continuity in procedures developed over

  4. Rejuvenation of automotive fuel cells

    DOEpatents

    Kim, Yu Seung; Langlois, David A.

    2016-08-23

    A process for rejuvenating fuel cells has been demonstrated to improve the performance of polymer exchange membrane fuel cells with platinum/ionomer electrodes. The process involves dehydrating a fuel cell and exposing at least the cathode of the fuel cell to dry gas (nitrogen, for example) at a temperature higher than the operating temperature of the fuel cell. The process may be used to prolong the operating lifetime of an automotive fuel cell.

  5. Proceedings of the 25th Annual Stirling Physics Meeting 1999

    NASA Astrophysics Data System (ADS)

    McVey, Michael

    1999-09-01

    The 25th Annual Stirling Physics meeting took place on Thursday 20 May on a warm sunny day when the country setting of Stirling Campus could be seen at its best. A total of 225 participants from all sectors of physics education attended. There was an opportunity to view and discuss with exhibitors a wide range of state-of-the-art equipment and teaching materials both before and after the meeting. The theme of the meeting was `Maintaining Standards'. Gemmel Millar, Scottish Branch Secretary acting as Chairperson for the morning session and in anticipation of the first speaker, wondered if a new unit qualification, the `Planck' might be introduced. Half units would then be `Short Plancks' and how many Short Plancks must there be in a unit? Great stuff. Scottish Qualifications Authority Hugh McGill began with a brief history and description of the Scottish Qualifications Authority. Born on 1 April 1997 (a light frisson of amusement swept through the audience) it was a unification between SEB and SCOTVEC and has a range of responsibilities covering schools, further and higher education. It oversees Standard and Higher grades, HNC and HND and SVQs, and it has 500 full-time employees as well as some 13500 appointees who act as examiners, assessors and verifiers etc, without whom its remit could not be carried out. The committee structure of the Board was outlined, one each for national and higher national qualifications and a third for Scottish vocational qualifications. These will be served by a proposed 19 Advisory Groups. The Science Advisory Group will be the key body for advising SQA on strategic developments to ensure that qualifications meet the needs of both client groups and end users. A consultation paper `Added Value To Learning' was referred to, in which all qualifications available in Scotland are given parity of esteem on a rising 11-point scale. Mr McGill stated that standards would be best maintained by ensuring continuity in procedures developed over

  6. Skin rejuvenation with intense pulsed light.

    PubMed

    Kohl, Elisabeth A; Babilas, Philipp; Landthaler, Michael

    2010-01-01

    Skin rejuvenation has developed into one of the most popular indications for laser and intense pulsed light (IPL) treatment in dermatology. During the past few years, nonablative skin rejuvenation with infrared lasers has become ever more popular. The results for hyperpigmentation, telangiectasias and erythema are very good, whereas the results in treating wrinkles are not as good as with ablative therapy. PMID:20887700

  7. Mosquito vector biology and control in Latin America - A 25th Symposium

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The 25th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 81st Annual Meeting in New Orleans, LA, in March 2015. The principal objective, for the previous 24 symposia, was to promote participation in the AMCA by vector control spec...

  8. Editorial: Special issue highlighting research presented at the 25th IWGO Conference, Chicago 2014

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A joint international conference was held among corn insect entomologists from 15 countries at the Allerton Hotel, Chicago, Illinois on April 13-17, 2014. It combined the 25th IWGO (International Working Group on Ostrinia and other maize pests) Conference with the 4th Diabrotica Genetics Conference,...

  9. REPORT FROM THE ORGANIZERS: The 25th International Conference on Low Temperature Physics

    NASA Astrophysics Data System (ADS)

    Kes, Peter

    2009-03-01

    The 25th International Conference on Low Temperature Physics (LT25) was hosted by the Kamerlingh Onnes Laboratorium of the Leiden Institute of Physics and held in the RAI Convention Center in Amsterdam, The Netherlands, 6-13 August 2008. It was the second time that the Kamerlingh Onnes Laboratory had the privilege of organizing an LT conference. In 1958, at LT6, 50 years of liquid helium temperatures were commemorated; in 2008 we celebrated the 100th anniversary of the remarkable achievements of Heike Kamerlingh Onnes and his collaborators in Leiden. In 1958 there were 323 participants and 145 papers appeared in the proceedings; in 2008 these numbers had increased to 1390 participants and 900 papers, of which eventually 849 were accepted. This large participation required adequate conference and housing facilities. These could not be found in Leiden, but were conveniently available in Amsterdam. The triennial International Low Temperature Conferences are organized under the auspices of the International Union of Pure and Applied Physics (IUPAP) through Commission C5 on Low Temperature Physics. It is the most important global meeting that brings together the international scientific community in the broad field of Low Temperature Physics. Because the meeting is held only every third year the 11 plenary and 22 half plenary talks (of 45 or 30 min.) generally provide an overview of important new discoveries over the last few years, whereas the 161 short oral presentations (20 min.) are mainly focused on very recent developments. Since the field is broad, embracing a large section of condensed matter physics, the program is divided into five parallel program lines: A. Quantum Gases, Fluids and Solids B. Superconductivity C. Quantum Phase Transitions and Magnetism D. Electronic Quantum Transport in Condensed Matter E. Cryogenic Techniques and Applications This distinction was used both to group the 1625 accepted abstracts, and the short-oral and poster presentations; the

  10. Niacin: an old drug rejuvenated.

    PubMed

    Kamanna, Vaijinath S; Ganji, Shobha H; Kashyap, Moti L

    2009-01-01

    Niacin has long been used in the treatment of dyslipidemia and cardiovascular disease. Recent research on niacin has been focused on understanding the mechanism of action of niacin and preparation of safer niacin formulations. New findings indicate that niacin does the following: 1) it inhibits hepatic diacylglycerol acyltransferase 2, resulting in inhibition of triglyceride synthesis and decreased apolipoprotein B-containing lipoproteins; 2) it decreases the surface expression of hepatic adenosine triphosphate synthase beta-chain, leading to decreased holoparticle high-density lipoprotein catabolism and increased high-density lipoprotein levels; and 3) it increases redox potential in arterial endothelial cells, resulting in inhibition of redox-sensitive genes. Flushing, an adverse effect of niacin, results from niacin receptor GPR109A-mediated production of prostaglandin D2 and E2 via DP1 and EP2/4 receptors. DP1 receptor antagonist (laropiprant) attenuates the niacin flush. A reformulated preparation of extended-release niacin (Niaspan; Abbott, Abbott Park, IL) lowers flushing compared with an older Niaspan formulation. These advancements in niacin research have rejuvenated its use for the treatment of dyslipidemia and cardiovascular disease. PMID:19080727

  11. Research activities on Antarctic middle atmosphere by JARE 25th team

    NASA Technical Reports Server (NTRS)

    Hirasawa, T.; Eiwasaka, Y. AFTANAKA, M. agfujii, r.0 typ; Eiwasaka, Y. AFTANAKA, M. agfujii, r.0 typ

    1985-01-01

    The Antarctic Middle Atmosphere (AMA)-Japan research project was set about by the JARE (Japan Antarctic Research Expedition) 23rd team in 1982, and since then the JARE-24th and JARE-25th teams have been continuing reseach on the Antarctic Middle Atmosphere. Results gained by JARE-25th team members who are now working at Syowa Station (69.99 deg S, 39.35 deg E), Antarctica are presented. In their activities satellite measurements (Exos-C) and rocket soundings are used. Three rockets of the S310 type were launched at Syowa Station (Geomagnetic Latitude = 69.9 deg S) for the purpose of directly observing the electron density, ionospheric temperature, auroral patterns and luminosity in situ. Vertical profiles of electron density and auroral emission 4278A measured by three rockets are compared.

  12. Mitochondrial Rejuvenation After Induced Pluripotency

    PubMed Central

    Tjong, Jonathan; Alcasid, Nathan; Perkins, Guy A.; Goissis, Marcelo D.; Ellisman, Mark H.; Perez, Gloria I.; Cibelli, Jose B.

    2010-01-01

    Background As stem cells of the early embryo mature and differentiate into all tissues, the mitochondrial complement undergoes dramatic functional improvement. Mitochondrial activity is low to minimize generation of DNA-damaging reactive oxygen species during pre-implantation development and increases following implantation and differentiation to meet higher metabolic demands. It has recently been reported that when the stem cell type known as induced pluripotent stem cells (IPSCs) are re-differentiated for several weeks in vitro, the mitochondrial complement progressively re-acquires properties approximating input fibroblasts, suggesting that despite the observation that IPSC conversion “resets” some parameters of cellular aging such as telomere length, it may have little impact on other age-affected cellular systems such as mitochondria in IPSC-derived cells. Methodology/Principal Findings We have examined the properties of mitochondria in two fibroblast lines, corresponding IPSCs, and fibroblasts re-derived from IPSCs using biochemical methods and electron microscopy, and found a dramatic improvement in the quality and function of the mitochondrial complement of the re-derived fibroblasts compared to input fibroblasts. This observation likely stems from two aspects of our experimental design: 1) that the input cell lines used were of advanced cellular age and contained an inefficient mitochondrial complement, and 2) the re-derived fibroblasts were produced using an extensive differentiation regimen that may more closely mimic the degree of growth and maturation found in a developing mammal. Conclusions/Significance These results — coupled with earlier data from our laboratory — suggest that IPSC conversion not only resets the “biological clock”, but can also rejuvenate the energetic capacity of derived cells. PMID:21124794

  13. REPORT FROM THE ORGANIZERS: The 25th International Conference on Low Temperature Physics

    NASA Astrophysics Data System (ADS)

    Kes, Peter

    2009-03-01

    The 25th International Conference on Low Temperature Physics (LT25) was hosted by the Kamerlingh Onnes Laboratorium of the Leiden Institute of Physics and held in the RAI Convention Center in Amsterdam, The Netherlands, 6-13 August 2008. It was the second time that the Kamerlingh Onnes Laboratory had the privilege of organizing an LT conference. In 1958, at LT6, 50 years of liquid helium temperatures were commemorated; in 2008 we celebrated the 100th anniversary of the remarkable achievements of Heike Kamerlingh Onnes and his collaborators in Leiden. In 1958 there were 323 participants and 145 papers appeared in the proceedings; in 2008 these numbers had increased to 1390 participants and 900 papers, of which eventually 849 were accepted. This large participation required adequate conference and housing facilities. These could not be found in Leiden, but were conveniently available in Amsterdam. The triennial International Low Temperature Conferences are organized under the auspices of the International Union of Pure and Applied Physics (IUPAP) through Commission C5 on Low Temperature Physics. It is the most important global meeting that brings together the international scientific community in the broad field of Low Temperature Physics. Because the meeting is held only every third year the 11 plenary and 22 half plenary talks (of 45 or 30 min.) generally provide an overview of important new discoveries over the last few years, whereas the 161 short oral presentations (20 min.) are mainly focused on very recent developments. Since the field is broad, embracing a large section of condensed matter physics, the program is divided into five parallel program lines: A. Quantum Gases, Fluids and Solids B. Superconductivity C. Quantum Phase Transitions and Magnetism D. Electronic Quantum Transport in Condensed Matter E. Cryogenic Techniques and Applications This distinction was used both to group the 1625 accepted abstracts, and the short-oral and poster presentations; the

  14. [Friedrich Nietzsche: history of his illness. On the 100th anniversary of the death of the poet-philosopher].

    PubMed

    Wilkes, J

    2000-04-01

    The philosopher Friedrich Nietzsche was one of the most famous patients in the psychiatric hospital Jena. Between 1889 and 1890, Otto Binswanger und Theodor Ziehen treated the progressive paralysis of Friedrich Nietzsche whose 100th anniversary of death is on 25th August 2000. After Nietzsche's death, an animated discussion about his disease arose. Many objected against the syphilitic diagnosis of the disease. Nietzsche's medical fill became a popular object of science, although it ended as a very odd story. PMID:10812640

  15. Exceptional Volumes of Rejuvenated Volcanism in Samoa

    NASA Astrophysics Data System (ADS)

    Konter, J. G.; Jackson, M.; Storm, L.

    2010-12-01

    The internal structure of within-plate volcanoes is typically compared to the stages of volcanic evolution in Hawaii. In Samoa, these stages show some differences with the Hawaiian model, in terms of the duration, volume and geochemical composition of the stages. Particularly, the rejuvenated stage of volcanism in Samoa is significantly more voluminous, with increasing geographic coverage with age, completely repaving the island of Savai’i. This unusual outpouring of rejuvenated lavas has previously been proposed to be related to the tectonic setting, near the northern terminus of the Tonga Trench. Therefore, Samoan volcanism might be caused by lithospheric fracturing, a mantle plume, or potentially a combination of the two. We collected new samples from a deeply eroded canyon on Savai’i to determine a time evolution of the transition from shield to eventual rejuvenated lavas. The canyon exposes several hundred meters of lavas, and we collected samples about 200m vertically down into the canyon. These samples are dominantly olivine basalts, and their Pb isotope compositions fall within the compositional field of young rejuvenated lavas on Savai’i and Upolu. This canyon section, therefore, represents a minimum thickness for the rejuvenated lavas of 200m. Assuming eruption of rejuvenated lavas only occurred subaerially, with a universal thickness of 200m, the new data suggest more than one percent of the volume of Savai’i consists of rejuvenated lavas. This is an order of magnitude greater than the largest relative volumes in Hawaii (Kauai), and implies a different cause for rejuvenated volcanism in Samoa. Another feature that suggests different processes may be important is the transition between the shield and rejuvenated stage. Although Samoan volcanoes do not seem to erupt exactly the same rock types as characteristic Hawaiian post-shield stage lavas, there is a definite shift to more evolved compositions (including trachytes) during the later stages of

  16. Predictions of the onset of mini ice age in the 25th solar cycle

    NASA Astrophysics Data System (ADS)

    Kumar, Rajiv

    2016-07-01

    Predictions of the ir-regularty in the 11 year heartbeat of the sun due to asyncronous of the two layered dynamo effect would result in mini ice age as in the Maunder minimum.The onset of this event is expected in the begining of 25th solar cycle and would go to its maximum in the 26th solar cycle.The minimum temperature is expected in 2028 due to the fall of solar activity by 60 % termed as solar hibernation.The predictions are based on the observations obtained by the Royal Greenwich observatory since 1874. Keywords: Dynamo effect,munder minimum,Solar hybernation

  17. Aging and brain rejuvenation as systemic events

    PubMed Central

    Bouchard, Jill; Villeda, Saul A

    2015-01-01

    The effects of aging were traditionally thought to be immutable, particularly evident in the loss of plasticity and cognitive abilities occurring in the aged central nervous system (CNS). However, it is becoming increasingly apparent that extrinsic systemic manipulations such as exercise, caloric restriction, and changing blood composition by heterochronic parabiosis or young plasma administration can partially counteract this age-related loss of plasticity in the aged brain. In this review, we discuss the process of aging and rejuvenation as systemic events. We summarize genetic studies that demonstrate a surprising level of malleability in organismal lifespan, and highlight the potential for systemic manipulations to functionally reverse the effects of aging in the CNS. Based on mounting evidence, we propose that rejuvenating effects of systemic manipulations are mediated, in part, by blood-borne ‘pro-youthful’ factors. Thus, systemic manipulations promoting a younger blood composition provide effective strategies to rejuvenate the aged brain. As a consequence, we can now consider reactivating latent plasticity dormant in the aged CNS as a means to rejuvenate regenerative, synaptic, and cognitive functions late in life, with potential implications even for extending lifespan. PMID:25327899

  18. The Daylight Bolide of 1996 April 25th , over Mt. Bruce, New Zealand

    NASA Astrophysics Data System (ADS)

    Wolf, G.; McBeath, A.

    On Thursday, 1996 April 25th (ANZAC Day in New Zealand) a bright daylight bolide with possible -22m end point, was seen from Newtown, Wellington, New Zealand at 02h20m12s. Its end-point altitude was calculated to be app. 15-20km over Mt. Bruce, some 80km NE of Wellington. A smoky train, initially 42deg long, was visible to the naked eye for 28 minutes afterwards. Sonics were heard by the New Zealand author, around 265s after the end point, suggesting a direct-line distance of 88km from the author's location. The impact point was probably several kilometers off Foxton Beach in the Tasman Sea. The bolide passed about 5deg above the first quarter Moon, and two photographs were secured, showing how the train began to drift, ultimately app. 17deg, to the south, before dissipating.

  19. Mosquito Vector Biology and Control in Latin America-A 25TH Symposium.

    PubMed

    2015-09-01

    The 25th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 81st Annual Meeting in New Orleans, LA, in March 2015. The principal objective, as for the previous 24 symposia, was to promote participation in the AMCA by vector control specialists, public health workers, and academicians from Latin America. This publication includes summaries of 24 presentations that were given orally in Spanish by participants from Colombia, Mexico, and the USA. Topics addressed in the symposium included: surveillance, operations, ecology, chemical control, studies of dengue viruses, and insecticide resistance. Insect vectors included Aedes, Culex, and Anopheles mosquitoes in addition to phlebotomine sand flies and triatomine bugs. PMID:26375913

  20. A single injection technique for midface rejuvenation.

    PubMed

    Cattin, Teresa A

    2010-09-01

    The correction of volume loss has become an important part of facial rejuvenation treatments, particularly in the midface region. Techniques to date have largely relied on multiple injections, fanning techniques and deep placement of product under muscle or on periosteum. This article describes a new technique to enhance volume in the midface using a single injection of cross-linked hyaluronic acid at the subdermal level and above the muscle. The technique approaches midface rejuvenation with reference to both the bony skeleton and the medial malar fat compartment. After appropriately marking the skin, the filler is placed using a blunt cannula. The treatment achieves satisfactory volume correction, enhancing the sharp cheek bones and malar fullness typical of an attractive adult face. The approach is simple, quick, and well tolerated by the patient and may result in less bruising than deeper techniques. PMID:20883303

  1. Impact on facial rejuvenation with dermatological preparations

    PubMed Central

    Bowler, Patrick J

    2009-01-01

    The treatment options for facial rejuvenation using dermatological, nonsurgical techniques have dramatically increased in the past 10 years. This follows the introduction of botulinum toxin and a variety of dermal fillers. The public interest in noninvasive treatments has changed the market beyond recognition with more physicians involved in providing services to satiate the demand. The impact on the public and medical profession is discussed. PMID:19503770

  2. A Software Rejuvenation Framework for Distributed Computing

    NASA Technical Reports Server (NTRS)

    Chau, Savio

    2009-01-01

    A performability-oriented conceptual framework for software rejuvenation has been constructed as a means of increasing levels of reliability and performance in distributed stateful computing. As used here, performability-oriented signifies that the construction of the framework is guided by the concept of analyzing the ability of a given computing system to deliver services with gracefully degradable performance. The framework is especially intended to support applications that involve stateful replicas of server computers.

  3. Structural rejuvenation in bulk metallic glasses

    DOE PAGESBeta

    Tong, Yang; Iwashita, T.; Dmowski, Wojciech; Bei, Hongbin; Yokoyama, Y.; Egami, Takeshi

    2015-01-05

    Using high-energy X-ray diffraction we study structural changes in bulk metallic glasses after uniaxial compressive homogeneous deformation at temperatures slightly below the glass transition. We observe that deformation results in structural disordering corresponding to an increase in the fictive, or effective, temperature. However, the structural disordering saturates after yielding. Lastly, examination of the experimental structure and molecular dynamics simulation suggests that local changes in the atomic connectivity network are the main driving force of the structural rejuvenation.

  4. Rejuvenation: an integrated approach to regenerative medicine.

    PubMed

    Kang, Y James; Zheng, Lily

    2013-12-01

    The word "rejuvenate" found in the Merriam-Webster dictionary is (1) to make young or youthful again: give new vigor to, and (2) to restore to an original or new state. Regenerative medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects. To accomplish this, approaches including transplantation, tissue engineering, cell therapy, and gene therapy are brought into action. These all use exogenously prepared materials to forcefully mend the failed organ. The adaptation of the materials in the host and their integration into the organ are all uncertain. It is a common sense that tissue injury in the younger is easily repaired and the acute injury is healed better and faster. Why does the elder have a diminished capacity of self-repairing, or why does chronic injury cause the loss of the self-repairing capacity? There must be some critical elements that are involved in the repair process, but are suppressed in the elder or under the chronic injury condition. Rejuvenation of the self-repair mechanism would be an ideal solution for functional recovery of the failed organ. To achieve this, it would involve renewal of the injury signaling, reestablishment of the communication and transportation system, recruitment of the materials for repairing, regeneration of the failed organ, and rehabilitation of the renewed organ. It thus would require a comprehensive understanding of developmental biology and a development of new approaches to activate the critical players to rejuvenate the self-repair mechanism in the elder or under chronic injury condition. Efforts focusing on rejuvenation would expect an alternative, if not a better, accomplishment in the regenerative medicine. PMID:25984326

  5. Land Processes Distributed Active Archive Center (LP DAAC) 25th Anniversary Recognition "A Model for Government Partnerships". LP DAAC "History and a Look Forward"

    NASA Technical Reports Server (NTRS)

    Behnke, Jeanne; Doescher, Chris

    2015-01-01

    This presentation discusses 25 years of interactions between NASA and the USGS to manage a Land Processes Distributed Active Archive Center (LPDAAC) for the purpose of providing users access to NASA's rich collection of Earth Science data. The presentation addresses challenges, efforts and metrics on the performance.

  6. The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters

    PubMed Central

    Golin, John; Ambudkar, Suresh V.

    2016-01-01

    Asymmetric ABC (ATP-binding cassette) transporters make up a significant proportion of this important superfamily of integral membrane proteins. These proteins contain one canonical (catalytic) ATP-binding site and a second atypical site with little enzymatic capability. The baker’s yeast (Saccharomyces cerevisiae) Pdr5 multidrug transporter is the founding member of the Pdr subfamily of asymmetric ABC transporters, which exist only in fungi and slime moulds. Because these organisms are of considerable medical and agricultural significance, Pdr5 has been studied extensively, as has its medically important homologue Cdr1 from Candida albicans. Genetic and biochemical analyses of Pdr5 have contributed important observations that are likely to be applicable to mammalian asymmetric ABC multidrug transporter proteins, including the basis of transporter promiscuity, the function of the non-catalytic deviant ATP-binding site, the most complete description of an in vivo transmission interface, and the recent discovery that Pdr5 is a molecular diode (one-way gate). In the present review, we discuss the observations made with Pdr5 and compare them with findings from clinically important asymmetric ABC transporters, such as CFTR (cystic fibrosis transmembrane conductance regulator), Cdr1 and Tap1/Tap2. PMID:25886173

  7. Honoring the 25th anniversary of the enactment of the Drug Price Competition and Patent Term Restoration Act of 1984 (the Hatch-Waxman Act).

    THOMAS, 111th Congress

    Sen. Brown, Sherrod [D-OH

    2009-09-24

    09/24/2009 Referred to the Committee on the Judiciary. (text of measure as introduced: CR S9853) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  8. SPECIAL ISSUE DEVOTED TO THE 25th ANNIVERSARY OF THE A.M. PROKHOROV GENERAL PHYSICS INSTITUTE: Femtosecond laser optical gas breakdown microplasma: the ionisation and postionisation dynamics

    NASA Astrophysics Data System (ADS)

    Bukin, V. V.; Garnov, S. V.; Malyutin, A. A.; Strelkov, V. V.

    2007-10-01

    The formation and evolution dynamics of the laser plasma produced in the microvolumes of gases (air, nitrogen, argon, and helium) upon their multiple ionisation by high-intensity (4×1016 W cm-2) tightly focused (to a region 1.7 μm in diameter) 400-nm, 100-fs second-harmonic pulses from a Ti:sapphire laser is studied. The spatiotemporal distribution profiles of the refractive index and electron microplasma density were recorded by ultrahigh-speed interferometry. The postionisation of a femtosecond laser plasma, i.e. the growth of the electron density known after the end of the exciting laser pulse, is detected for the first time. A theoretical model is proposed, which describes the mechanism of plasma postionisation by hot photoelectrons. The results of electron density calculations are in good agreement with experimental data.

  9. "25 Years of Educational Excellence." Special Issue Commemorating the 25th Anniversary of the Journal of the Pennsylvania Black Conference on Higher Education, Inc.

    ERIC Educational Resources Information Center

    Redfern, Alicia King, Ed.

    1996-01-01

    The articles in this document are intended to be reflective of the theme "A Silver Celebration: 25 Years of Educational Excellence," and cover topics ranging from black college athletes to black real estate owners to the status of African Americans in Pennsylvania colleges and universities. They include: "The Social and Political Dimensions of…

  10. 25th anniversary article: what can be done with the Langmuir-Blodgett method? Recent developments and its critical role in materials science.

    PubMed

    Ariga, Katsuhiko; Yamauchi, Yusuke; Mori, Taizo; Hill, Jonathan P

    2013-12-01

    The Langmuir-Blodgett (LB) technique is known as an elegant method for fabrication of well-defined layered structures with molecular level precision. Since its discovery the LB method has made an indispensable contribution to surface science, physical chemistry, materials chemistry and nanotechnology. However, recent trends in research might suggest the decline of the LB method as alternate methods for film fabrication such as layer-by-layer (LbL) assembly have emerged. Is LB film technology obsolete? This review is presented in order to challenge this preposterous question. In this review, we summarize recent research on LB and related methods including (i) advanced design for LB films, (ii) LB film as a medium for supramolecular chemistry, (iii) LB technique for nanofabrication and (iv) LB involving advanced nanomaterials. Finally, a comparison between LB and LbL techniques is made. The latter reveals the crucial role played by LB techniques in basic surface science, current advanced material sciences and nanotechnologies. PMID:24302266

  11. Teaching Biochemistry at Lisbon University--Facing the Challenge of the Bologna Declaration in the 25th Anniversary of the Biochemistry Course

    ERIC Educational Resources Information Center

    Farinha, Carlos M.; Freire, Ana Ponces

    2007-01-01

    The biochemistry degree has been taught at Lisbon University for 25 years. Since its creation, the curriculum is characterized for being widely eclectic and multidisciplinary. The adoption of the concepts proposed in Europe by the Declaration of Bologna and incorporation of these ideas at Lisbon University is discussed here for the biochemistry…

  12. The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters.

    PubMed

    Golin, John; Ambudkar, Suresh V

    2015-05-01

    Asymmetric ABC (ATP-binding cassette) transporters make up a significant proportion of this important superfamily of integral membrane proteins. These proteins contain one canonical (catalytic) ATP-binding site and a second atypical site with little enzymatic capability. The baker's yeast (Saccharomyces cerevisiae) Pdr5 multidrug transporter is the founding member of the Pdr subfamily of asymmetric ABC transporters, which exist only in fungi and slime moulds. Because these organisms are of considerable medical and agricultural significance, Pdr5 has been studied extensively, as has its medically important homologue Cdr1 from Candida albicans. Genetic and biochemical analyses of Pdr5 have contributed important observations that are likely to be applicable to mammalian asymmetric ABC multidrug transporter proteins, including the basis of transporter promiscuity, the function of the non-catalytic deviant ATP-binding site, the most complete description of an in vivo transmission interface, and the recent discovery that Pdr5 is a molecular diode (one-way gate). In the present review, we discuss the observations made with Pdr5 and compare them with findings from clinically important asymmetric ABC transporters, such as CFTR (cystic fibrosis transmembrane conductance regulator), Cdr1 and Tap1/Tap2. PMID:25886173

  13. 11th Annual LVMH Recherche Symposium: skin rejuvenation.

    PubMed

    Bonté, Frédéric

    2012-01-01

    The 11(th) Annual LVMH Recherche Scientific Symposium was held in London on October 27(th), into the warmth of the distinguished British Library, with nearly 150 industry and research attendees. The meeting organized by LVMH Recherche was centered on the theme of skin rejuvenation. The current state of play for rejuvenation research was summarized, and then advances in the science of skin aging and rejuvenation therapies were discussed in detail. Personalized genomics and current and prospective translational therapies were presented, followed by a clever linking of multiple global theories towards a cohesive plan for future goals in rejuvenation research. PMID:22615002

  14. Proceedings of the 25th Seismic Research Review -- Nuclear Explosion Monitoring: Building the Knowledge Base

    SciTech Connect

    Chavez, Francesca C.; Mendius, E. Louise

    2003-09-23

    These proceedings contain papers prepared for the 25th Seismic Research Review -- Nuclear Explosion Monitoring: Building the Knowledge Base, held 23-25 September, 2003 in Tucson, Arizona. These papers represent the combined research related to ground-based nuclear explosion monitoring funded by the National Nuclear Security Administration (NNSA), Defense Threat Reduction Agency (DTRA), Air Force Research Laboratory (AFRL), US Army Space and Missile Defense Command, and other invited sponsors. The scientific objectives of the research are to improve the United States capability to detect, locate, and identify nuclear explosions. The purpose of the meeting is to provide the sponsoring agencies, as well as potential users, an opportunity to review research accomplished during the preceding year and to discuss areas of investigation for the coming year. For the researchers, it provides a forum for the exchange of scientific information toward achieving program goals, and an opportunity to discuss results and future plans. Paper topics include: seismic regionalization and calibration; detection and location of sources; wave propagation from source to receiver; the nature of seismic sources, including mining practices; hydroacoustic, infrasound, and radionuclide methods; on-site inspection; and data processing.

  15. The extended SMAS approach to neck rejuvenation.

    PubMed

    Perkins, Stephen W; Waters, Heather H

    2014-05-01

    Jowling, submental lipoptosis, and platysmal banding can affect self-image and reduce quality of life, leading one to seek facial and neck rejuvenation. With realistic expectations, a facelift can provide the desired improvement in appearance and sense of well-being. Before any intervention, a detailed history, focused examination, communication of expected outcomes with the assistance of preoperative digital imaging, and discussion of perioperative instructions are of utmost importance. Although many techniques exist, the modified deep plane extended superficial muscular aponeurotic system rhytidectomy with submentoplasty reliably delivers a significant improvement with lasting results. PMID:24745387

  16. Partial rejuvenation of a colloidal glass.

    PubMed

    Ozon, F; Narita, T; Knaebel, A; Debrégeas, G; Hébraud, P; Munch, J-P

    2003-09-01

    We study the effect of shear on the aging dynamics of a colloidal suspension of synthetic clay particles. We find that a shear of amplitude gamma reduces the relaxation time measured just after the cessation of shear by a factor exp(-gamma/gamma(c)), with gamma(c) approximately 5%, and is independent of the duration and the frequency of the shear. This simple law for the rejuvenation effect shows that the energy involved in colloidal rearrangements is proportional to the shear amplitude gamma rather than gamma(2), leading to an Eyring-like description of the dynamics of our system. PMID:14524814

  17. Noninvasive Facial Rejuvenation. Part 1: Patient-Directed.

    PubMed

    Commander, Sarah Jane; Chang, Daniel; Fakhro, Abdulla; Nigro, Marjory G; Lee, Edward I

    2016-08-01

    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin and rejuvenate damaged skin. Physicians may recommend and often prescribe certain products, but the patients are in control of this type of facial rejuvenation. On the other hand, physician-directed facial rejuvenation entails modalities that require direct physician involvement, such as neuromodulators, filler injections, laser resurfacing, microdermabrasion, and chemical peels. With the successful integration of each of these modalities, a complete facial regimen can be established and patient satisfaction can be maximized. This article is the first in a three-part series describing noninvasive facial rejuvenation. The authors focus on patient-directed facial rejuvenation. It is important, however, to emphasize that even in a patient-directed modality, a physician's involvement through education and guidance is integral to its success. PMID:27478421

  18. PREFACE: 25th International Congress on Condition Monitoring and Diagnostic Engineering (COMADEM 2012)

    NASA Astrophysics Data System (ADS)

    Ball, Andrew; Mishra, Rakesh; Gu, Fengshou; Rao, Raj B. K. N.

    2012-05-01

    The proactive multidisciplinary conceptual philosophy of Condition Monitoring and Diagnostic Engineering Management (COMADEM) was conceived and has been nurtured, developed and sustained since 1988. Since then, it is gratifying to note that the condition monitoring, diagnostic and prognostic community worldwide (representing industrialists, academics, research and development organizations, professional/private establishments and many hardware/software vending organizations) has warmly welcomed and supported this venture. As is evidenced, many have reaped (and are reaping) the benefits of COMADEM interdiscipline through continuous knowledge discovery, generation and dissemination. We are now proud to celebrate the 25th Annual Event (Silver Jubilee) in Huddersfield, the most beautiful part of the United Kingdom. The theme of this Congress is 'Sustained Prosperity through Proactive Monitoring, Diagnosis, Prognosis and Management'. This proceedings is enriched by contributions from many keynote experts representing many industry and academic establishments worldwide. Authors from more than 30 different countries have pooled their rich multidisciplinary up-to-date knowledge, in order to share their invaluable experience with the COMADEM community. In this proceedings, the readers will find more than 120 refereed papers encompassing a number of topical areas of interest relating to the theme of the congress. The proceedings of COMADEM 2012 will appear in the Open Access Journal of Physics: Conference Series (JPCS), which is part of the IOP Conference Series. All papers published in the IOP Conference Series are fully citable and upon publication will be free to download. We would like to express our deep gratitude to all the keynote speakers, authors, referees, exhibitors, Technical Co-Sponsoring Organizations, Gold Sponsors, IOP Publishers, COMADEM 2012 organizing committee members, delegates and many others on whom the success of this prestigious event depends

  19. [Progresses in therapeutic strategies for thymic rejuvenation].

    PubMed

    Tan, Jian-Xin; Wang, Ya-Jun; Zhu, Xi-Ke

    2016-02-25

    The thymus is a vital primary lymphoid organ that provides unique microenvironments for the proliferation, differentiation, and maturation of T cells. With advancing age, however, the thymus gradually undergoes age-related involution and reduction in immune function, which are characterized by decreases in tissue size, cellularity, and naïve T cell output. This dynamic process leads to the reduced efficacy of the immune system with age and contributes to the increased susceptibility to infection, autoimmune disease, and cancer. In addition, bone marrow transplantation, radio-chemotherapy and virus infection also impair the thymus and give rise to the decline in immune function. Therefore, understanding the molecular mechanisms involved in age-related thymic involution and development of novel therapeutic strategies for thymic rejuvenation have gained considerable interests in recent years. This review emphasizes thymic microenvironments and thymocyte-stromal cell interactions and summarizes our current knowledge about thymic rejuvenation in terms of sex steroid, cytokines, growth factors, hormones, transcription factors, cell graft, and microRNAs. At the end of each discussion, we also highlight unanswered issues and describe possible future research directions. PMID:26915325

  20. Facial rejuvenation and light: our personal experience.

    PubMed

    Trelles, Mario A; Mordon, Serge; Calderhead, R Glen

    2007-06-01

    The treatment of ageing skin remains a very hot topic, and many systems have been reported as having varying degrees of success. Nonablative lasers were developed to avoid the problematic and uncomfortable sequelae following laser ablative resurfacing, and while there was no downtime, there was also poor patient satisfaction. The same was true of the intense pulsed light systems. The use of different modalities in various combinations was found to offer much better results, however, such as a 595-nm pulsed dye laser followed by a 1,450-nm diode laser, and so on, all used at subablative thresholds. The recent entry of blue and infrared tunable plasma light and light-emitting diodes into the skin rejuvenation arena has attracted a great deal of attention. The authors suggest that no single modality can accomplish all the complex events required for effective skin rejuvenation, suggest that combination phototherapy is the best approach combined with an adjunctive epidermal care regimen, and demonstrate their development of this methodology. PMID:17122954

  1. TRMM 3-Year Anniversary

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Ever wonder about the rain? Beyond the practicality of needing an umbrella, climate researchers have wondered about the science of rainfall for a long time. But it's only in the past few years that they've begun to roll back some of its secrets. One of their tools for doing so is a powerful satellite called the Tropical Rainfall Measuring Mission, or TRMM. Now, after three years of continual operation, project scientists have released dramatic new maps of rainfall patterns gathered across a wide band of the Earth. And with measurements from one of the satellite's advanced sensors, meteorologists are now able to calibrate ground-based rain monitoring systems with greater precision than ever before. A complete accounting of the world's total rainfall has long been a major goal of climate researchers. Rain acts as the atmosphere's fundamental engine for heat exchange; every time a raindrop falls, the atmosphere gets churned up and latent heat flows back into the total climate system. Considering that rainfall is the primary driving force of heat in the atmosphere, and that two thirds of all rain falls in the tropics, these measurements are significant for our understanding of overall climate. The above image shows a one month average of rainfall measurements taken by the TRMM's unique precipitation radar during January of 1998. Areas of low rainfall are colored light blue, while regions with heavy rainfal are colored orange and red. TRMM began collecting data in December of 1997, and continues today. For more information about TRMM's 3-year anniversary, read Maps of Falling Water To learn more about the TRMM mission or order TRMM data, see the TRMM Home Page. Image courtesy TRMM Science team and the NASA GSFC Scientific Visualization Studio.

  2. Earthquake Forecasts for Gorkha Immediately Following the 25th April, M=7.8 Mainshock

    NASA Astrophysics Data System (ADS)

    Segkou, M.; Parsons, T.

    2015-12-01

    The M-7.8 Gorkha (Nepal) earthquake on the 25th April, 2015 has shaken the central Himalayan front and immediately raised concerns for the severity of future triggered earthquakes. Here, we implement standard and innovative forecast models to predict the spatio-temporal distribution of triggered events. Key challenges addressed are: 1) the limited information on early aftershocks, 2) the low-productivity aftershock sequence in the near-source area, 3) the off-fault (>250 km) triggered events exemplified by the M=5.4 Xegar event, 3 hrs after the mainshock. We apply short-term empirical/statistical ETAS and physical forecast models, the latter based on the combination of rate/state friction law and Coulomb stresses. Within the physics-based model implementation we seek to evaluate the uncertainty related with the rupture style of triggered events by considering: 1) the geometry of active structures, 2) optimally oriented for failure faults and 3) all-potential faults described by the total stress field. The latter is represented by the full stress tensor before and after the mainshock and our analysis suggests that the preseismic stress magnitudes are still sufficient to cause earthquakes even after modification by the mainshock. The above remark reveals that there are no "stress shadows" affecting the spatial distribution of near-field aftershocks. It is also noted that the method allows for an a-priori determination of the rupture plan of the M=7.3 event, within the limit of uncertainty (20˚). The results show that: (1) ETAS models underestimate the number of observed events, since they heavily base their good performance in small magnitude earthquakes, not available in the first few weeks after the mainshock, (2) far field triggered events are captured only by physics-based forecasts, and (3) the total stress method improves the predictability of larger magnitude events. We conclude that frontier regions benefit from the implementation of physics-based models

  3. Forever young: rejuvenating muscle satellite cells

    PubMed Central

    Madaro, Luca; Latella, Lucia

    2015-01-01

    A hallmark of aging is alteration of organismal homeostasis and progressive decline of tissue functions. Alterations of both cell intrinsic functions and regenerative environmental cues contribute to the compromised stem cell activity and reduced regenerative capability occurring in aged muscles. In this perspective, we discuss the new evidence supporting the hypothesis that skeletal muscle stem cells (MuSCs) are intrinsically defective in elderly muscles. In particular, we review three recent papers leading to identify fibroblast growth factor receptor-1, p38 mitogen-activated protein kinase, and p16INK4a as altered signaling in satellite cells from aged mice. These pathways contribute to age-related loss of MuSCs asymmetric polarization, compromised self-renewal capacity, and acquisition of pre-senescent state. The pharmacological manipulation of those networks can open novel strategies to rejuvenate MuSCs and counteract the functional decline of skeletal muscle during aging. PMID:25954192

  4. The neural rejuvenation hypothesis of cocaine addiction.

    PubMed

    Dong, Yan; Nestler, Eric J

    2014-08-01

    A leading hypothesis guiding current molecular and cellular research into drug addiction conceptualizes key aspects of addiction as a form of memory in which common neuroplasticity mechanisms that mediate normal learning and memory processes are 'hijacked' by exposure to drugs of abuse to produce pathologic addiction-related memories. Such addiction-related memories are particularly robust and long-lasting and once formed are less amenable to updating. Here we propose a neural rejuvenation hypothesis of cocaine addiction. According to this hypothesis, repeated exposure to drugs of abuse induces some plasticity mechanisms normally associated with brain development within the reward circuitry that mediate the highly efficient and unusually stable memory abnormalities that characterize addiction. PMID:24958329

  5. The Neural Rejuvenation Hypothesis of Cocaine Addiction

    PubMed Central

    Dong, Yan; Nestler, Eric J.

    2014-01-01

    A leading hypothesis guiding current molecular and cellular research of drug addiction conceptualizes key aspects of addiction as a form of memory, in which common neuroplasticity mechanisms that mediate normal learning and memory processes are “hijacked” by exposure to drugs of abuse to produce pathologic addiction-related memories. Such addiction-related memories are particularly robust and long-lasting and once formed, less amenable to updating. Here, we propose the Neural Rejuvenation Hypothesis of Cocaine Addiction: that repeated exposure to drugs of abuse induces some plasticity mechanisms that are normally associated with brain development within the brain’s reward circuitry, which mediate the highly efficient and unusually stable memory abnormalities that characterize addiction. PMID:24958329

  6. Galvanostatic Ion Detrapping Rejuvenates Oxide Thin Films.

    PubMed

    Arvizu, Miguel A; Wen, Rui-Tao; Primetzhofer, Daniel; Klemberg-Sapieha, Jolanta E; Martinu, Ludvik; Niklasson, Gunnar A; Granqvist, Claes G

    2015-12-01

    Ion trapping under charge insertion-extraction is well-known to degrade the electrochemical performance of oxides. Galvanostatic treatment was recently shown capable to rejuvenate the oxide, but the detailed mechanism remained uncertain. Here we report on amorphous electrochromic (EC) WO3 thin films prepared by sputtering and electrochemically cycled in a lithium-containing electrolyte under conditions leading to severe loss of charge exchange capacity and optical modulation span. Time-of-flight elastic recoil detection analysis (ToF-ERDA) documented pronounced Li(+) trapping associated with the degradation of the EC properties and, importantly, that Li(+) detrapping, caused by a weak constant current drawn through the film for some time, could recover the original EC performance. Thus, ToF-ERDA provided direct and unambiguous evidence for Li(+) detrapping. PMID:26599729

  7. Stockpile Stewardship's 20th Anniversary

    SciTech Connect

    Hecker, Siegfried; Gottemoeller, Rose; Reis, Victor H.; McMillan, Charles; Rohlfing, Joan; Hurricane, Omar; Hagengruber, Roger; Taylor, John

    2015-10-22

    A short oral history of the NNSA's Stockpile Stewardship Program, produced in association with the 20th anniversary of the program. It features Siegfried Hecker, Rose Gottemoeller, Victor Reis, Charles McMillan, Joan Rohlfing, Omar Hurricane, Roger Hagengruber, and John Taylor.

  8. A Gradual Compositional Change from Samoan Shield to Rejuvenated Lavas?

    NASA Astrophysics Data System (ADS)

    Konter, J. G.; Jackson, M. G.; Koppers, A. A.

    2013-12-01

    The geochemical evolution of intraplate volcanoes is often compared to the archetypal model derived from Hawaiian volcanoes that involves a mantle plume source with multiple components. In Samoa, a range in rock types, ages, and isotopic compositions have been obtained across a number of volcanic seamounts and islands. However, due to dense vegetation on the islands, stratigraphic relations are not well known, and therefore a sequence for the construction of Samoan volcanoes is not as well-defined as in Hawaii. On the three largest islands, a shield and a rejuvenated stage have been defined, whereas the existence of a post-shield stage has been suggested and questioned (Natland and Turner, 1985). Moreover, the existing shield isotopic compositions (particularly Sr) are distinct, spanning a larger range than in Hawaii. Tutuila only hosts a small amount of rejuvenated lavas, but they are similar to those of Upolu, and there is an isotopic and compositional overlap between Tutuila shield volcanics and the Upolu lavas. On the island of Upolu, roughly half the surface area is covered in rejuvenated lavas, while the other half consists of shield stage lavas. The shield lavas around Fagaloa Bay are compositionally similar to some of the Tutuila lavas. On the island of Savaii, rejuvenated volcanism covers nearly the entire island, showing similar compositions to Upolu rejuvenated volcanism. We here present new data for samples from a deep canyon in the interior of Savaii, which form the missing link in understanding the geochemical sequence of Samoan volcanic construction. In this canyon, an isotopically distinct composition is found that resembles the composition of Fagaloa lavas on Upolu, instead of the extremely radiogenic Sr isotope compositions dredged from the submarine base of Savaii that represent the early shield stage. In Fagaloa Bay, a slope break on the mountainside has been suggested to form the outline of a crater along which late-stage evolved lavas such as

  9. Modeling Aging and Mechanical Rejuvenation of Amorphous Solids

    NASA Astrophysics Data System (ADS)

    Semkiv, Mykhailo; Hütter, Markus

    2016-04-01

    The elasto-viscoplasticity of amorphous solids is modeled, with a focus on the effects of physical aging and mechanical rejuvenation. Using nonequilibrium thermodynamics, the concept of kinetic and configurational subsystems has been employed. The Hamiltonian structure of reversible dynamics is exploited to derive a constitutive relation for the stress tensor. Furthermore, it is demonstrated that accounting for mechanical rejuvenation results in a modification of the driving force for viscoplastic flow.

  10. Shield Through Rejuvenated Stage Volcanism On Kauai and Niihau, Hawaii

    NASA Astrophysics Data System (ADS)

    Cousens, B.; Clague, D. A.

    2013-12-01

    Kauai and Niihau are the northwesternmost large islands in the Hawaiian chain and consist of shield, rare postshield, and abundant rejuvenated stage lavas. We present new geochronological, geochemical and isotopic data for all phases of volcanic activity on the adjacent islands. K-Ar ages show Niihau shield volcanism occurred from 6.3-4.4 Ma, and K-Ar and new Ar-Ar ages for postshield volcanism range from 5.4-4.7 Ma. Kauai shield volcanism (K-Ar) overlaps with shield volcanism on Niihau. A new Ar-Ar age for a Kauai postshield dike is 4.4 Ma, older than previously-dated postshield lavas (3.95-3.58 Ma). New Ar-Ar ages show that Kauai rejuvenated stage volcanism began prior to 3.42 Ma (Izuka & Sherrod, 2011), compared to ~2.3 Ma on Niihau. Tholeiitic shield lavas from Kauai vary only slightly in trace element chemistry but have variable isotopic compositions. Subtle trends in some trace element and isotopic ratios between Napali Member shield lavas from the east and west side of Kauai support the two-shield hypothesis of Holcomb et al. (1997). Shield lavas from Niihau are chemically similar to those on Kauai, although Niihau tholeiites extend to higher 143Nd/144Nd ratios. Onland and submarine postshield rocks from Niihau are slightly more alkaline and LREE-enriched compared to shield lavas, but postshield rocks from Kauai are more chemically evolved, more LREE-enriched, and have more depleted Sr and Nd isotopic signatures than Kauai tholeiites. Postshield rocks on Kauai overlap in apparent age with lavas that are chemically like later rejuvenated stage lavas, suggesting either interfingering of the chemically distinct lavas or problems with the K-Ar ages. Rejuvenated stage lavas from the two islands differ dramatically; Kauai lavas are alkaline, LREE-enriched, and have even more depleted Sr and Nd isotopic compositions than postshield lavas, whereas Niihau lavas are only mildly alkaline, have lower REE abundances than postshield basalts, but isotopically are like

  11. Happy Anniversary, VLT !

    NASA Astrophysics Data System (ADS)

    2004-04-01

    Five years at the service of Europe's astronomers VLT 5 Years One of the world's most advanced astronomical research facilities, the ESO Very Large Telescope (VLT) at the Paranal Observatory in the Chilean Atacama desert, celebrates an important anniversary today. On April 1, 1999, and following almost one year of extensive tests and careful trimming of its numerous high-tech parts, the first 8.2-m VLT Unit Telescope, Antu (UT1), was "handed over" to the astronomers. Since that date, science operations with this marvellous research tool have been continuous and intensive. Kueyen (UT2) started normal operations exactly one year later. Yepun (UT4) was offered to the scientific community in June 2001, while Melipal (UT3) followed in August 2001 [1]. Ever since, all four VLT Unit Telescopes, with an ever-growing suite of highly specialised, extremely powerful astronomical instruments have been in full operation, 365 nights a year. And this with unequalled success, as demonstrated by a long list of important scientific results, including a substantial number of exciting discoveries that are now opening new horizons in astrophysics. Moreover, thanks to heroic and persistent efforts by the dedicated teams of ESO scientists and engineers, the "downtime" due to technical problems has been very small, about 3 per cent, a number that is unequalled among the world's large telescope facilities. In addition, the weather conditions at the Paranal site in the dry Atacama desert in Northern Chile are truly excellent - this is indeed one of the best locations for astronomical observations on the surface of the Earth - and the corresponding "weather downtime" has only been around 10 per cent. This has resulted in an unbelievably low value of total downtime, most likely a new world record for ground-based 8-10 m class telescopes. VLT strong points The Very Large Telescope (VLT) is the world's largest and most advanced optical telescope. It comprises four 8.2-m reflecting Unit

  12. Robotic-Assisted Upper Face Rejuvenation

    PubMed Central

    Rybakin, Arthur V.; Manturova, Natalia E.; Gladyshev, Dmitriy V.; Kamalov, David M.; Shcherbakov, Kirill G.; Staisupov, Valeriy J.; Kuzin, Danila A.

    2016-01-01

    Summary: Robotic-assisted technology has not been used in aesthetic surgery so far. The authors examined the feasibility and potential advantages of robotic-assisted technology in upper face rejuvenation surgery, as well as utility of the tools available in the market. Forehead lift was performed along with blepharoplasty in 4 patients. Robotic da Vinci Surgical System (Intuitive Surgical, Inc.) was used at the stage of dissection. The stereo endoscope 30 degrees, 12 mm and later 8.5 mm in diameter, and the set of tools, 8 mm and later 5 mm in diameter, were used. Overall results appeared to be essentially the same as after usual endoscope-assisted brow lift. The advantages of the robotic-assisted surgery were as follows: the best possible display, scalability of the picture; lack of tremor, scalability of the movements’ amplitude; high degree of freedom of movements exceeding human capabilities; quick and easy switch between the endoscope and any of the 3 manipulating arms; and enhanced comfort for a surgeon. The drawbacks noted were as follows: cost, steep learning curve, lack of tactile feedback, and absence of instruments specially adjusted for aesthetic surgery. The authors conclude that robots will enter the field of aesthetic plastic surgery in the same way as endoscopy, the proviso being to adjust tools to the specific needs.

  13. Surface rejuvenating effect of Achillea millefolium extract.

    PubMed

    Pain, S; Altobelli, C; Boher, A; Cittadini, L; Favre-Mercuret, M; Gaillard, C; Sohm, B; Vogelgesang, B; André-Frei, V

    2011-12-01

    Proopiomelanocortin is a precursor peptide that gives rise to several neuropeptides including adrenocorticotrophic hormone (ACTH) and β-endorphin. POMC-derived peptides have been shown to be synthesized in human epidermis where they modulate numerous skin functions. Because we previously observed that melanocortin receptor-2 and μ-opioid receptor 1, the respective receptors for ACTH and β-endorphin decreased with ageing in human epidermis, we have selected an active ingredient (INCI name: Achillea millefolium extract) able to upregulate receptor expressions. The aim of the present work was first to evaluate the effect of A. millefolium extract on the expression pattern of various epidermal differentiation markers ex vivo in normal human skin biopsies using quantitative image analysis and second to evaluate its capacity to rejuvenate the appearance of skin surface in vivo. Results show an improved expression profile of cytokeratin 10, transglutaminase-1 and filaggrin in cultured skin biopsies as well as an increased epidermal thickness. In vivo, a 2-month treatment with A. millefolium extract at 2% significantly improved the appearance of wrinkles and pores compared with placebo. Results were also directionally better than those of glycolic acid that was chosen as reference resurfacing molecule. PMID:21711463

  14. Newly diagnosed hyperthyroidism in the 25th gestational week of pregnancy presenting with systolic arterial hypertension only.

    PubMed

    Zaveljcina, Janez; Legan, Mateja; Gaberšček, Simona

    2016-05-01

    We present a case of a 30-year-old woman diagnosed with arterial hypertension in the 25th week of pregnancy. Our search for secondary causes of arterial hypertension revealed hyperthyroid Hashimoto's thyroiditis (HT), which was treated with propilthiouracil. Three weeks after delivery, she was normotensive without medication. In the next four months, she developed hypothyroidism and treatment with L-thyroxine was started. In conclusion, in the second half of pregnancy, a hyperthyroid HT can occur - in spite of the well-known amelioration of autoimmune thyroid disorders in that period, and can be the only cause of arterial hypertension. PMID:26979941

  15. 25th IAEA Fusion Energy Conference: summary of sessions EX/S, EX/W and ICC

    NASA Astrophysics Data System (ADS)

    Sen, A.

    2015-10-01

    This paper provides a summary overview, based on papers presented at the 25th IAEA Fusion Energy Conference (FEC), in the area of magnetic confinement experiments related to stability (EX/S), wave-plasma interactions, current drive, heating, energetic particles (EX/W) and innovative confinement concepts (ICCs). A selection of results that represent progress made since the last FEC in a few important thematic areas that are relevant for the successful and safe operation of future fusion devices like ITER, is highlighted.

  16. Happy Anniversary, VLT !

    NASA Astrophysics Data System (ADS)

    2004-04-01

    Five years at the service of Europe's astronomers VLT 5 Years One of the world's most advanced astronomical research facilities, the ESO Very Large Telescope (VLT) at the Paranal Observatory in the Chilean Atacama desert, celebrates an important anniversary today. On April 1, 1999, and following almost one year of extensive tests and careful trimming of its numerous high-tech parts, the first 8.2-m VLT Unit Telescope, Antu (UT1), was "handed over" to the astronomers. Since that date, science operations with this marvellous research tool have been continuous and intensive. Kueyen (UT2) started normal operations exactly one year later. Yepun (UT4) was offered to the scientific community in June 2001, while Melipal (UT3) followed in August 2001 [1]. Ever since, all four VLT Unit Telescopes, with an ever-growing suite of highly specialised, extremely powerful astronomical instruments have been in full operation, 365 nights a year. And this with unequalled success, as demonstrated by a long list of important scientific results, including a substantial number of exciting discoveries that are now opening new horizons in astrophysics. Moreover, thanks to heroic and persistent efforts by the dedicated teams of ESO scientists and engineers, the "downtime" due to technical problems has been very small, about 3 per cent, a number that is unequalled among the world's large telescope facilities. In addition, the weather conditions at the Paranal site in the dry Atacama desert in Northern Chile are truly excellent - this is indeed one of the best locations for astronomical observations on the surface of the Earth - and the corresponding "weather downtime" has only been around 10 per cent. This has resulted in an unbelievably low value of total downtime, most likely a new world record for ground-based 8-10 m class telescopes. VLT strong points The Very Large Telescope (VLT) is the world's largest and most advanced optical telescope. It comprises four 8.2-m reflecting Unit

  17. Unspiked K-Ar Dating Of Hawaiian Rejuvenated Volcanism

    NASA Astrophysics Data System (ADS)

    Tagami, T.; Ozawa, A.; Sano, H.; Sherrod, D. R.

    2005-12-01

    Many mantle plume volcanoes undergo rejuvenated volcanism after a period of construction and erosion of their shield. The cause of this renewed volcanism has been enigmatic, and various models have been proposed. However, the lack of chronological data has hindered evaluating these models. Here we summarize below our recent results of unspiked K-Ar dating on rejuvenated lavas from five Hawaiian volcanoes. These ages, coupled with other geological and geophysical constraints, will be used to test the models. (1) Haleakala (East Maui) (Sherrod et al., 2003): The postshield and previously inferred rejuvenated-stage history was reevaluated using 52 new ages. Periods of low extrusion rates or volcanic quiescence occurred at ~0.76 - 0.65 Ma and ~0.45 - 0.29 Ma, both within the postshield Kula unit. The volcanic quiescence between postshield and supposed rejuvenated-stage units is about 0.03 m.y., much shorter than the previously estimated period of 0.25 - 0.30 m.y. (2) West Maui (Tagami et al., 2003; Sherrod et al., in prep.): Rejuvenated-stage Lahaina Volcanics were erupted from only four sites and their new ages indicate two volcanic pulses at about 0.6 and 0.4 Ma. Nine ages for the underlying postshield and 28 for shield stage units range from 1.8 - 1.3 Ma and 1.3 - 1.2 Ma, respectively. Therefore, the duration of volcanic quiescence prior to rejuvenation is about 0.6 m.y. at West Maui, much longer than estimated previously. (3) Koolau, Oahu (Ozawa et al., 2005): New ages on 41 samples from 32 vents of rejuvenated-stage Honolulu Volcanics and on eight samples of underlying shield-stage Koolau Volcanics show that shield volcanism ended at 2.1 Ma and that rejuvenated volcanism started at 0.8 Ma, resulting in a 1.3 m.y. hiatus in volcanic activity. Two distinct pulses were found for Honolulu volcanism at 0.8 - 0.35 and ~0.1 Ma. During the first pulse, the eruption frequency increased with time and there was no obvious spatial pattern in vent distribution. Volcanism

  18. Controlled Rejuvenation of Amorphous Metals with Thermal Processing

    PubMed Central

    Wakeda, Masato; Saida, Junji; Li, Ju; Ogata, Shigenobu

    2015-01-01

    Rejuvenation is the configurational excitation of amorphous materials and is one of the more promising approaches for improving the deformability of amorphous metals that usually exhibit macroscopic brittle fracture modes. Here, we propose a method to control the level of rejuvenation through systematic thermal processing and clarify the crucial feasibility conditions by means of molecular dynamics simulations of annealing and quenching. We also experimentally demonstrate rejuvenation level control in Zr55Al10Ni5Cu30 bulk metallic glass. Our local heat-treatment recipe (rising temperature above 1.1Tg, followed by a temperature quench rate exceeding the previous) opens avenue to modifying the glass properties after it has been cast and processed into near component shape, where a higher local cooling rate may be afforded by for example transient laser heating, adding spatial control and great flexibility to the processing. PMID:26010470

  19. Pins and needles: minimally invasive office techniques for facial rejuvenation.

    PubMed

    Maas, Corey S; Bapna, Sumit

    2009-11-01

    The desire for minimally invasive facial rejuvenation has continued to increase from the perspective of both the patients and injectors. For successful rejuvenation, it is important to understand the anatomic changes of the aging face as well as the properties of available neuromodulators and soft tissue fillers. The injector should be knowledgeable of the advantages and disadvantages of each product. Patient selection, perhaps, plays the largest role in success, choosing patients that would truly benefit from and have reasonable expectations for minimally invasive techniques. Unsatisfactory outcomes can be limited by meticulous injection technique and well thought out treatment plans. PMID:19924599

  20. Systemic Problems: A perspective on stem cell aging and rejuvenation.

    PubMed

    Conboy, Irina M; Conboy, Michael J; Rebo, Justin

    2015-10-01

    This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are "beyond parabiosis" for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging. PMID:26540176

  1. Systemic Problems: A perspective on stem cell aging and rejuvenation

    PubMed Central

    Conboy, Irina M.; Conboy, Michael J.; Rebo, Justin

    2015-01-01

    This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a “silver bullet” putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are “beyond parabiosis” for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging. PMID:26540176

  2. Rejuvenation of the skin surface: chemical peel and dermabrasion.

    PubMed

    Branham, G H; Thomas, J R

    1996-04-01

    Chemical peel and dermabrasion are traditional, well-proven methods for the rejuvenation of the skin. The medium-depth trichloroacetic acid peel and the deep phenol peel offer distinct advantages and disadvantages and are discussed in detail in this article. The management of complications associated with both peel techniques is also discussed. Regional dermabrasion is an effective adjunct to facial rejuvenative surgery, such as face lift and blepharoplasty. Full-face dermabrasion and spot or local dermabrasion are most often used in the treatment of facial scarring. The technique of dermabrasion is discussed as well as its indications and postoperative care. Results are shown for both dermabrasion and peel. PMID:9220727

  3. Announcement: CDC's 70th Anniversary.

    PubMed

    2016-01-01

    July 1, 2016, marks the 70th anniversary of the establishment of CDC. Since the agency's launch as the Communicable Disease Center on July 1, 1946, CDC's primary mission has been improving public health in the United States and around the world through prevention and preparedness. In the seven decades since CDC's founding, the agency has grown in size and mission and is recognized as the nation's premiere health promotion, disease prevention, and emergency preparedness agency, and a global leader in public health. CDC's mission has progressed beyond communicable disease control and now encompasses noninfectious diseases, injury prevention, and environmental and occupational health. PMID:27362420

  4. Update on hyaluronic acid fillers for facial rejuvenation.

    PubMed

    Mansouri, Yasaman; Goldenberg, Gary

    2015-08-01

    Injectable soft tissue filler procedures are becoming increasingly important for rejuvenating the aging face. The variety of available dermal fillers is increasing, and an understanding of their individual characteristics allows optimal outcomes. We provide an overview of the dermal fillers that were approved by the US Food and Drug Administration over the last 5 years. PMID:26367746

  5. Brow suspension, a minimally invasive technique in facial rejuvenation.

    PubMed

    Erol, O Onur; Sozer, S Ozan; Velidedeoglu, Hifzi V

    2002-06-01

    People tend to prefer noninvasive or minimally invasive methods of facial rejuvenation, especially when it involves their face, which is the hallmark of a person's identity and impossible to hide. It is widely known that brow ptosis gives the face a "tired look" and also accentuates deformities of the upper eyelid. Most people who are interested in facial rejuvenation may not accept even a minor surgery, such as an endoscopic surgery. The senior author has developed a minimally invasive method of suspending the brow at a higher position. In this technique, there is neither surgical dissection nor a surgical incision except for four stab incisions and suture insertion, which is why we refer to it as a nonsurgical brow suspension. It is done under local anesthesia, and the brows are fixed in the position that they assume when the patient is supine. In the past 6 years, we performed 387 brow suspensions on 324 female and 63 male patients. The youngest patient was 19 years old, and the oldest was 74 years old. A retrospective chart review was done. These 387 cases were reviewed by comparison of preoperative and postoperative photographs. This approach was not only used for patients who were not interested in surgical rejuvenation but was also combined with lipofilling, laser resurfacing, and/or upper blepharoplasty. This technique is useful for correcting postsurgical brow asymmetry. We present this technique as an adjunct to the established techniques of facial rejuvenation. Despite the high patient acceptance and technical ease, it is not a replacement for the established techniques of facial rejuvenation. PMID:12045586

  6. Photopneumatic Technology in Acne Treatment and Skin Rejuvenation: Histological Assessment

    PubMed Central

    Omi, Tokuya

    2012-01-01

    Background and Aims: Recent reports indicate that a variety of light-based devices have been used for acne treatment and skin rejuvenation. A new technology combining intense pulsed light with negative pressure, photopneumatic technology, has recently attracted interest. The present study assessed acne treatment and skin rejuvenation with this novel approach Subjects and Methods: Acne, 450 nm tip. Five Japanese volunteers (1 male, 4 female; mean age 28.6 yr; skin type III) with mild to moderate/moderate active acne participated. The face was treated with 2 sessions, 2 weeks apart. Biopsies were obtained immediately after the first session and 1 week after the second session, and routinely processed for transmission electron microscopy (TEM). Rejuvenation, profusion tip with topical preparation. In 5 Japanese volunteers (3 male, 2 female; mean age 37.6 yr, skin type III), the volar aspect of both forearms was treated with the 530 nm head at P6 (around 12 J/cm2). The left arm was then treated with a pre-infused profusion tip and vacuum only. Four sessions were given, 14-day intervals. Biopsies were taken from both arms 2 weeks after the 2nd session and 3 weeks after the 4th session. One-half of each biopsy was assessed with histo-and immunohistochemistry, and the other with TEM. Results Acne trial: A combination of physical extraction of comedones, mild photothermal damage of the follicle and damage to identified bacilli was noted post-treatment, with macroscopic improvement of the skin. Rejuvenation with profusion: Significant morphological and immunohistochemical differences were seen between the control and profusion-treated arms at the first assessment. These differences became less significant at the 2nd assessment. Conclusions Macroscopically and histologically, photopneumatic technology improved acne lesions, suggesting a synergistic effect between the components of the technology. In skin rejuvenation, the profusion therapy accelerated the regenerative

  7. Pandemic Influenza's 500th Anniversary

    PubMed Central

    Morens, David M.; Taubenberger, Jeffery K.; Folkers, Gregory K.; Fauci, Anthony S.

    2010-01-01

    It is impossible to know with certainty the first time that an influenza virus infected humans or when the first influenza pandemic occurred. However, many historians agree that the year 1510 a.d.—500 years ago—marks the first recognition of pandemic influenza. On this significant anniversary it is timely to ask: what were the circumstances surrounding the emergence of the 1510 pandemic, and what have we learned about this important disease over the subsequent five centuries?We conclude that in recent decades significant progress has been made in diagnosis, prevention, control, and treatment of influenza. It seems likely that, in the foreseeable future, we may be able to greatly reduce the burden of influenza pandemics with improved vaccines and other scientific and public health approaches. PMID:21067353

  8. The ESA Hubble 15th Anniversary Campaign

    NASA Astrophysics Data System (ADS)

    Christensen, L. L.; Kornmesser, M.

    2005-12-01

    The 15th anniversary of the launch of the NASA/ESA Hubble Space Telescope occurred on 24th April 2005. As Hubble is one of the most successful scientific projects in the world, ESA decided to celebrate this anniversary, among other things, with the production of a Hubble 15th Anniversary movie and a book, both called "Hubble, 15 years of discovery". The movie covers all aspects of the Hubble Space Telescope project - a journey through the history, the problems and the scientific successes of Hubble. With more than 700,000 multi-lingual DVDs distributed to the public, media, educators, decision-makers and scientists, the Hubble 15th anniversary campaign has been one of the largest such projects in Europe.

  9. Skin rejuvenation with non-invasive pulsed electric fields.

    PubMed

    Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P; Albadawi, Hassan; Felix Broelsch, G; Watkins, Michael T; Georgakoudi, Irene; Papisov, Mikhail; Mihm, Martin C; Austen, William G; Yarmush, Martin L

    2015-01-01

    Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases. PMID:25965851

  10. Skin Rejuvenation with Non-Invasive Pulsed Electric Fields

    PubMed Central

    Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P.; Albadawi, Hassan; Felix Broelsch, G.; Watkins, Michael T.; Georgakoudi, Irene; Papisov, Mikhail; Mihm Jr., Martin C.; Austen Jr., William G.; Yarmush, Martin L.

    2015-01-01

    Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases. PMID:25965851

  11. Skin Rejuvenation with Non-Invasive Pulsed Electric Fields

    NASA Astrophysics Data System (ADS)

    Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P.; Albadawi, Hassan; Felix Broelsch, G.; Watkins, Michael T.; Georgakoudi, Irene; Papisov, Mikhail; Mihm, Martin C., Jr.; Austen, William G., Jr.; Yarmush, Martin L.

    2015-05-01

    Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases.

  12. Deeply Rooted, Branching Out, 1972-1997. Annual AEE International Conference Proceedings (25th, Asheville, North Carolina, November 23-26, 1997).

    ERIC Educational Resources Information Center

    Harwell, Rick, Ed.; Comstedt, Timothea, Ed.; Roberts, Nina, Ed.

    This proceedings contains 36 papers presented at the 25th Annual Conference of the Association for Experiential Education. Papers are: "The Woods and the Trees: Interpreting Experiential Education for Schools and a Greater Audience" (Joanna Allen, John Hutchinson); "Adventure Programming & Prevention of Adolescent Problem Behaviors: Applying…

  13. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (25th, Utrecht, The Netherlands, July 12-17, 2001). Volumes 1-4.

    ERIC Educational Resources Information Center

    van den Heuvel-Panhuizen, Marja, Ed.

    This document contains the proceedings of the 25th annual Conference of the International Group for the Psychology of Mathematics Education (PME). It features plenary lectures, research forums, discussion groups, working sessions, short oral communications, and poster presentations. Papers in Volume 1 include: (1) "The P in PME: Progress and…

  14. Visual Literacy in the Digital Age: Selected Readings from the Annual Conference of the International Visual Literacy Association (25th, Rochester, New York, October 13-17, 1993).

    ERIC Educational Resources Information Center

    Beauchamp, Darrel G.; And Others

    This document contains selected papers from the 25th annual conference of the International Visual Literacy Association (IVLA). Topics addressed in the papers include the following: visual literacy; graphic information in research and education; evaluation criteria for instructional media; understanding symbols in business presentations;…

  15. Teaching of Psychology: Ideas and Innovations. Proceedings of the Annual Conference (25th, Tarrytown, New York, March 25-26, 2011)

    ERIC Educational Resources Information Center

    Howell-Carter, Marya, Ed.; Gonder, Jennifer, Ed.

    2011-01-01

    Conference proceedings of the 25th Annual Conference on the Teaching of Psychology: Ideas and Innovations, sponsored by the Psychology Department of the State University of New York at Farmingdale. The conference theme for 2011 was: The Future of the Undergraduate Psychology Major: New Directions in an Evolving Educational Climate. The Conference…

  16. Months between rejuvenation and volcanic eruption at Yellowstone caldera, Wyoming

    USGS Publications Warehouse

    Till, Christy B.; Vazquez, Jorge A.; Boyce, Jeremy W

    2015-01-01

    Rejuvenation of previously intruded silicic magma is an important process leading to effusive rhyolite, which is the most common product of volcanism at calderas with protracted histories of eruption and unrest such as Yellowstone, Long Valley, and Valles, USA. Although orders of magnitude smaller in volume than rare caldera-forming super-eruptions, these relatively frequent effusions of rhyolite are comparable to the largest eruptions of the 20th century and pose a considerable volcanic hazard. However, the physical pathway from rejuvenation to eruption of silicic magma is unclear particularly because the time between reheating of a subvolcanic intrusion and eruption is poorly quantified. This study uses geospeedometry of trace element profiles with nanometer resolution in sanidine crystals to reveal that Yellowstone’s most recent volcanic cycle began when remobilization of a near- or sub-solidus silicic magma occurred less than 10 months prior to eruption, following a 220,000 year period of volcanic repose. Our results reveal a geologically rapid timescale for rejuvenation and effusion of ~3 km3 of high-silica rhyolite lava even after protracted cooling of the subvolcanic system, which is consistent with recent physical modeling that predict a timescale of several years or less. Future renewal of rhyolitic volcanism at Yellowstone is likely to require an energetic intrusion of mafic or silicic magma into the shallow subvolcanic reservoir and could rapidly generate an eruptible rhyolite on timescales similar to those documented here.

  17. Case study: An isolated severe storm with giant hail hit Slovenian capital city Ljubljana on May 25th 2009

    NASA Astrophysics Data System (ADS)

    Korosec, M.

    2009-09-01

    Introduction A quite unusual weather pattern for month of May with first and early season heat wave of year 2009 resulted in several days of active severe storms across central Europe and Alpine region. Synoptic situation On May 25th 2009, an omega block pattern with strong upper-level subtropical ridge extending over Mediterranean and Balkan Peninsula brought stable and warm conditions into Southern Europe. Elsewhere, two large-scale troughs were located over Western and Eastern Europe with very unstable environment. On the nose of the Mediterranean ridge a jet streak with moderate shear was placed while over the Southern Alpine region only weak shear was placed over Slovenia. Rich boundary layer moisture and steep lapse rates within an elevated mixed layer favored extreme amounts of CAPE. After strong diurnal heating and surface wind convergence along the local topography a few convective cells were triggered in the mountainous terrain while deep moist convection over the rest of Slovenia was trapped by the strong capping inversion. In late afternoon several cells from the mountainous terrain interfered with each other and explosive convective cell was initiated along their outflow boundaries. Increasing near surface southeasterly wind flow supported enhanced low-level shear and storm relative helicity which caused this cell to very rapidly grown into an organized supercell storm on the flat terrain in northern Slovenia. This supercell then started racing southeastwards towards Ljubljana, a capital city of Slovenia. It caused extensive hail damage with very large to giant hailstones up to 7cm in diameter falling over parts of Ljubljana and areas north and southeast of the city. Presentation of research This case study will go through a research of this very damaging hailstorm, throughout a detailed analysis of the synoptic situation including analysis of satellite, radar and surface observations. At first, forecasting models did not suggest organized convection

  18. MedlinePlus Marks its 15th Anniversary

    MedlinePlus

    ... page: https://medlineplus.gov/anniversary.html MedlinePlus Marks its 15 th Anniversary To use the sharing features ... people across the country and around the world. It now includes: Over 950 pages providing links to ...

  19. The silver anniversary of gold: 25 years of the colloidal gold marker system for immunocytochemistry and histochemistry.

    PubMed

    Roth, J

    1996-07-01

    Since 1971, when W.P. Faulk and G.M. Taylor published "An immunocolloid method for the electron microscope", colloidal gold has become a very widely used marker in microscopy. It has been used to detect a huge range of cellular and extracellular constituents by in situ hybridization, immunogold, lectin-gold, and enzyme-gold labeling. Besides its use in light microscopic immunogold and lectin-gold silver staining, colloidal gold remains the label of choice for transmission electron microscopy studying thin sections, freeze-etch, and surface replicas, as well as for scanning electron microscopy. The year 1996 is the 25th anniversary of the introduction of colloidal gold as a marker in immunoelectron microscopy and this overview outlines some of the major milestones in the development of the colloidal gold marker system. PMID:8858362

  20. 46 CFR 90.10-1 - Anniversary date.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Definition of Terms Used in This Subchapter § 90.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate of... 46 Shipping 4 2013-10-01 2013-10-01 false Anniversary date. 90.10-1 Section 90.10-1 Shipping...

  1. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate... 46 Shipping 7 2011-10-01 2011-10-01 false Anniversary date. 188.10-1 Section 188.10-1...

  2. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate... 46 Shipping 7 2012-10-01 2012-10-01 false Anniversary date. 188.10-1 Section 188.10-1...

  3. 46 CFR 90.10-1 - Anniversary date.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Definition of Terms Used in This Subchapter § 90.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate of... 46 Shipping 4 2011-10-01 2011-10-01 false Anniversary date. 90.10-1 Section 90.10-1 Shipping...

  4. 46 CFR 90.10-1 - Anniversary date.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Definition of Terms Used in This Subchapter § 90.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate of... 46 Shipping 4 2014-10-01 2014-10-01 false Anniversary date. 90.10-1 Section 90.10-1 Shipping...

  5. 46 CFR 90.10-1 - Anniversary date.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Definition of Terms Used in This Subchapter § 90.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate of... 46 Shipping 4 2012-10-01 2012-10-01 false Anniversary date. 90.10-1 Section 90.10-1 Shipping...

  6. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate... 46 Shipping 7 2010-10-01 2010-10-01 false Anniversary date. 188.10-1 Section 188.10-1...

  7. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate... 46 Shipping 7 2014-10-01 2014-10-01 false Anniversary date. 188.10-1 Section 188.10-1...

  8. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate... 46 Shipping 7 2013-10-01 2013-10-01 false Anniversary date. 188.10-1 Section 188.10-1...

  9. 46 CFR 90.10-1 - Anniversary date.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Definition of Terms Used in This Subchapter § 90.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the Certificate of... 46 Shipping 4 2010-10-01 2010-10-01 false Anniversary date. 90.10-1 Section 90.10-1 Shipping...

  10. Injectable Filler Techniques for Facial Rejuvenation, Volumization, and Augmentation.

    PubMed

    Bass, Lawrence S

    2015-11-01

    Multiple fillers are available: various hyaluronic acid products, calcium hydroxylapatite, and a few others that are biocompatible with good duration and a variety of mechanical properties allowing intradermal, subdermal, and supraperiosteal injection. Facial features can be reshaped with great control using these fillers. Aging changes, including facial volume loss, can be well-corrected. These treatments have become a mainstay of rejuvenation in the early facial aging patient. Injection technique is critical to obtaining excellent results. Threading, fanning, cross-hatching, bleb, and pillar techniques must be mastered. Technical execution can only measure up to, but not exceed, the quality of the aesthetic analysis. PMID:26505544

  11. Strong rejuvenation in a chiral-glass superconductor

    NASA Astrophysics Data System (ADS)

    Gardchareon, A.; Mathieu, R.; Jönsson, P. E.; Nordblad, P.

    2003-02-01

    The glassy paramagnetic Meissner phase of a Bi2Sr2CaCu2Ox superconductor (x=8.18) is investigated by superconducting quantum interference device magnetometry, using “dc-memory” experiments employed earlier to study spin glasses. The temperature dependence of the zero-field-cooled and thermoremanent magnetization is recorded on reheating after specific cooling protocols, in which single or multiple halts are performed at constant temperatures. The “spin” states equilibrated during the halts are retrieved on reheating. The observed memory and rejuvenation effects are similar to those observed in Heisenberg-like spin glasses.

  12. Hand Rejuvenation: A Comprehensive Review of Fat Grafting.

    PubMed

    Hoang, Don; Orgel, Matthew I; Kulber, David A

    2016-05-01

    Dermal atrophy, bulging reticular veins, and prominent bones and tendons are characteristic of the aging hand. Demand for cosmetic procedures to restore a youthful appearance to the dorsum of the hand has risen in recent years. A review of the literature reveals that of the many options for hand restoration, autologous fat grafting stands out as the most promising choice compared with many available alternative options such as microdermabrasion, peeling agents, and dermal fillers. This article details the surgical technique and relevant anatomy necessary for successful hand rejuvenation. Future advancements may rely on further study into adipose-derived stem cells. PMID:27113709

  13. Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

    PubMed Central

    Rando, Thomas A.; Chang, Howard Y.

    2012-01-01

    The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges. PMID:22265401

  14. Rejuvenation in scale-free optics and enhanced diffraction cancellation life-time.

    PubMed

    Parravicini, J; Conti, C; Agranat, A J; DelRe, E

    2012-11-19

    We demonstrate rejuvenation in scale-free optical propagation. The phenomenon is caused by the non-ergodic relaxation of the dipolar glass that mediates the photorefractive nonlinearity in compositionally-disordered lithium-enriched potassium-tantalate-niobate (KTN:Li). We implement rejuvenation to halt aging in the dipolar glass and extend the duration of beam diffraction cancellation. PMID:23187594

  15. Addressing anniversary reactions of trauma through group process: the Hurricane Katrina anniversary wellness workshops.

    PubMed

    Nemeth, Darlyne G; Kuriansky, Judy; Reeder, Kenneth P; Lewis, Amity; Marceaux, Kristin; Whittington, Taighlor; Olivier, Traci W; May, Natasha E; Safier, Jessica A

    2012-01-01

    Natural disasters such as Hurricane Katrina, which devastated the Gulf Coast of the United States in the summer of 2005, have highlighted the need to develop effective post-trauma psychotherapeutic intervention strategies, not only to deal with the immediate psychological aftermath of trauma, but also the long-term effects of anniversary reactions. Governmental responses to Hurricane Katrina relief were greatly criticized for disorganization and delay. Both immediately afterwards and in ensuing months, people's life needs often were not addressed. People-to-people individual and group grassroots efforts, including those provided by mental health professionals, however, did reach local communities to service immediate needs and long-term emotional reactions. The present paper describes one such effort designed to help survivors cope on the occasion of the first anniversary of Hurricane Katrina. Specifically, anniversary reaction group workshops were held to address unresolved emotional issues and to promote healing by encouraging belonging, comfort, security, and resilience. The ultimate goal of these wellness workshops was to assist participants in understanding and resolving their anniversary reactions. Preliminary quantitative and qualitative findings suggested that this workshop format helped participants face their anniversary reactions, address their related psychological sequelae, and deal with their physical displacement. Participants were then able to find the emotional strength to reattach, form new communities, and begin problem solving. These methods, with appropriate cultural modifications, were subsequently used in China, to assist Chinese mental health professionals prepare for the first anniversary of the Sichuan earthquake. PMID:22229372

  16. EDITORIAL: 50th anniversary issue

    NASA Astrophysics Data System (ADS)

    Beddoe, Alun H.

    2006-07-01

    In July 1956, 50 years ago, the first issue of Physics in Medicine and Biology (PMB) was published. It was subtitled The Journal of the Hospital Physicists' Association and published in association with the Philosophical Magazine by Taylor and Francis. Subscriptions were £1 per part or £3 10s for an annual subscription. The Editor, Professor J E Roberts, prefaced the first issue with a cautious editorial noting: The appearance of a new journal is usually greeted with mixed feelings by scientific workers, a common response being that there are far too many journals already. Justification for a new publication is only possible if there is a clearly defined gap in the publishing facilities available to workers in a particular scientific field.... Professor Roberts ended by seeking support from the scientific community for the new venture. He certainly got it! From a tentative few hundred pages in four issues a year for the first few years, the journal is now issued twice monthly with nearly 8000 pages expected in volume 51. In this anniversary issue we have invited some 28 senior authors to submit papers on a range of subjects spanning the discipline. We decided that to be an author one had to be old, but age was not to be the only criterion! Indeed readers will recognize all names as major contributors to both the development of medical physics and the success of PMB. Authors were not asked to write formal topical reviews of the state-of-the-art of the sub-disciplines which make up medical physics, but rather to present short historical reviews, didactic in style, perhaps highlighting the role of PMB in the development of their fields. Nevertheless, other than a page limit (which many subsequently ignored!) no formal format was imposed on authors, so what follows is a range of contributions from the almost conversational, personal statement to the more formal and familiar scientific paper. Whatever the writing style we are confident that readers will gain some

  17. Hydration of Acetylene: A 125th Anniversary

    ERIC Educational Resources Information Center

    Ponomarev, Dmitry A.; Shevchenko, Sergey M.

    2007-01-01

    The year 2006 is the 125th anniversary of a chemical reaction, the discovery of which by Mikhail Kucherov had a profound effect on the development of industrial chemistry in the 19-20th centuries. This was the hydration of alkynes catalyzed by mercury ions that made possible industrial production of acetaldehyde from acetylene. Historical…

  18. Space agency notes 20th anniversary

    NASA Technical Reports Server (NTRS)

    Frosch, R. A.

    1978-01-01

    The twentieth anniversary of NASA is announced. A chronology of major milestones of the NASA program is given along with a brief outline of the programs and responsibilities of NASA Headquarters and the NASA centers and facilities. The NASA launch record is included.

  19. Columbines 10th Anniversary Finds Lessons Learned

    ERIC Educational Resources Information Center

    Trump, Kenneth S.

    2009-01-01

    When school administrators hear that the 10th anniversary of the Columbine High School attack is approaching, most shake their heads in disbelief. They are amazed that 10 years have passed since this watershed event, which changed the landscape of K-12 school safety. In this article, the author reflects on the lessons learned from the Columbine…

  20. The First Reactor, 40th Anniversary (rev.)

    SciTech Connect

    Allardice, Corbin; Trapnell, Edward R; Fermi, Enrico; Fermi, Laura; Williams, Robert C

    1982-12-01

    This booklet, an updated version of the original booklet describing the first nuclear reactor, was written in honor of the 40th anniversary of the first reactor or "pile". It is based on firsthand accounts told to Corbin Allardice and Edward R. Trapnell, and includes recollections of Enrico and Laura Fermi.

  1. The Neglected Majority--20th Anniversary

    ERIC Educational Resources Information Center

    Beebe, Anthony E.; Walleri, R. Dan

    2005-01-01

    It is the 20th anniversary of the release of Dale Parnell's landmark book "The Neglected Majority". In this book, Parnell pointed out that for too long America's educational system has focused on the highest and lowest achievers. He made the case that most of those students in the middle two high school quartiles neither prepare for nor aspire to…

  2. [World War II 50th Anniversary.

    ERIC Educational Resources Information Center

    Johnson, Jeniffer, Ed.

    1991-01-01

    This edition of "Loblolly," a periodical published by Texas high school students, commemorates the 50th anniversary of World War II. The volume features remembrances of the War by veterans of Panola County, Texas. In addition to transcriptions of conversations with veterans, reproductions of photographs--some from the war period, some from more…

  3. Lymphedema fat graft: an ideal filler for facial rejuvenation.

    PubMed

    Nicoli, Fabio; Chilgar, Ram M; Sapountzis, Stamatis; Lazzeri, Davide; Sze Wei, Matthew Yeo; Ciudad, Pedro; Nicoli, Marzia; Lim, Seong Yoon; Chen, Pei-Yu; Constantinides, Joannis; Chen, Hung-Chi

    2014-09-01

    Lymphedema is a chronic disorder characterized by lymph stasis in the subcutaneous tissue. Lymphatic fluid contains several components including hyaluronic acid and has many important properties. Over the past few years, significant research has been performed to identify an ideal tissue to implant as a filler. Because of its unique composition, fat harvested from the lymphedema tissue is an interesting topic for investigation and has significant potential for application as a filler, particularly in facial rejuvenation. Over a 36-month period, we treated and assessed 8 patients with lymphedematous limbs who concurrently underwent facial rejuvenation with lymphedema fat (LF). We conducted a pre- and post-operative satisfaction questionnaire survey and a histological assessment of the harvested LF fat. The overall mean general appearance score at an average of 6 months after the procedure was 7.2±0.5, demonstrating great improvement. Patients reported significant improvement in their skin texture with a reading of 8.5±0.7 and an improvement in their self-esteem. This study demonstrates that LF as an ideal autologous injectable filler is clinically applicable and easily available in patients with lymphedema. We recommend the further study and clinical use of this tissue as it exhibits important properties and qualities for future applications and research. PMID:25276654

  4. Extracellular Matrix Modulation: Optimizing Skin Care and Rejuvenation Procedures.

    PubMed

    Widgerow, Alan D; Fabi, Sabrina G; Palestine, Roberta F; Rivkin, Alexander; Ortiz, Arisa; Bucay, Vivian W; Chiu, Annie; Naga, Lina; Emer, Jason; Chasan, Paul E

    2016-04-01

    Normal aging and photoaging of the skin are chronic processes that progress gradually. The extracellular matrix (ECM), constituting over 70% of the skin, is the central hub for repair and regeneration of the skin. As such, the ECM is the area where changes related to photodamage are most evident. Degradation of the ECM with fragmentation of proteins significantly affects cross talk and signaling between cells, the matrix, and its constituents. The accumulation of collagen fragments, amorphous elastin agglutinations, and abnormal cross-linkages between the collagen fragments impedes the ECM from its normal repair and regenerative capacity, which manifests as wrinkled, non-elastic skin. Similar to how the chronic wound healing process requires wound bed preparation before therapeutic intervention, treatment of chronic aging of the skin would likely benefit from a "skin bed preparation" to optimize the outcome of rejuvenation procedures and skin maintenance programs. This involves introducing agents that can combat stress-induced oxidation, proteasome dysfunction, and non-enzymatic cross linkages involved in glycation end products, to collectively modulate this damaged ECM, and upregulate neocollagenesis and elastin production. Agents of particular interest are matrikines, peptides originating from the fragmentation of matrix proteins that exhibit a wide range of biological activities. Peptides of this type (tripeptide and hexapeptide) are incorporated in ALASTIN™ Skin Nectar with TriHex™ technology (ALASTIN Skincare, Inc., Carlsbad, CA), which is designed to target ECM modulation with a goal of optimizing results following invasive and non-invasive dermal rejuvenating procedures. PMID:27050707

  5. A possible mechanism for visible-light-induced skin rejuvenation

    NASA Astrophysics Data System (ADS)

    Longo, Leonardo; Lubart, Rachel; Friedman, Harry; Lavie, R.

    2004-09-01

    In recent years there has been intensive research in the field of non-ablative skin rejuvenation. This comes as a response to the desire for a simple method of treating rhytids caused by aging, UV exposure and acne scars. In numerous studies intense visible light pulsed systems (20-30J/cm2) are used. The mechanism of action was supposed to be a selective heat induced denaturalization of dermal collagen that leads to subsequent reactive synthesis. In this study we suggest a different mechanism for photorejuvenation based on light induced Reactive Oxygen Species (ROS) formation. We irradiated collagen in-vitro with a broad band of visible light, 400-800 nm, 12-22J/cm2, and used the spin trapping coupled with electron paramagnetic resonance (EPR) spectroscopy to detect ROS. In vivo, we used dose 30 J in average (35 for acnis scars, 25 for wrinkles and redness). Irradiated collagen results in hydroxyl and methyl radicals formation. We propose, as a new concept, that visible light at the intensity used for skin rejuvenation, 20-30J/cm2, produces high amounts of ROS which destroy old collagen fibers encouraging the formation of new ones. On the other hand at inner depths of the skin, where the light intensity is much weaker, low amounts of ROS are formed which are well known to stimulate fibroblast proliferation.

  6. Multidisciplinary Investigations of the Galápagos Rift, 86°W to 89.5°W: 25th Anniversary of the Discovery of Hydrothermal Venting

    NASA Astrophysics Data System (ADS)

    Hammond, S. R.; Shank, T. M.; Fornari, D. J.; Yoerger, D. R.; Bradley, A. M.; Scheirer, D. S.; Tivey, M. A.

    2002-12-01

    In May-June, 2002, a multidisciplinary expedition comprised of biologists, chemists, geologists and engineers conducted a field program on the Galápagos Rift between 86°W and 89.5°W. Objectives of the expedition included revisiting the site of one of the first-discovered low-temperature hydrothermal vents at Rose Garden (originally found in 1979), and searching for new low- and high-temperature vents along the largely unexplored western portion of the Galápagos Rift to 89.5°W. The field work was funded primarily by NOAA's Ocean Exploration Program with additional support from the National Science Foundation and Woods Hole Oceanographic Institution. A synergistic array of deep-ocean vehicles was used for the exploration program. Alvin and a new digital towed camera were used for making seafloor observations, acquiring digital imagery and collecting samples. An autonomous vehicle ABE (Autonomous Benthic Explorer), which acquired meter-scale bathymetry, near-bottom magnetics and bottom water-properties data, was utilized to explore for active hydrothermal venting. Water-column vertical casts and tow-yos with a CTD/rosette were used to explore for plumes emanating from high-temperature vents. Alvin and ABE were used to explore for the Rose Garden vent field near 86°13.5'W. Detailed bottom-water temperature maps and seafloor magnetics data, in conjunction with visual and photographic observations from Alvin and the towed camera, confirmed that the Rose Garden vent field and associated animal community no longer exists, and that prolonged high-temperature venting appears to never have occurred in this area. However, a new low-temperature vent field (which was named Rosebud) was discovered nearby at a depth of 2450 m, and was found to be developing on a fresh-looking sheet flow at a location approximately 200 m northwest of the former Rose Garden area. A second site of low-temperature hydrothermal activity, at 1670 m, was discovered on a portion of the unexplored rift near 89.5°W. This venting is the first discovered along this portion of the Galápagos Rift and it hosts a large vesicomyid (C. magnifica) clam community that covers an approximately 60 m x 60 m area. Throughout the cruise, ABE was used during night operations to provide synoptic micro-bathymetry maps, magnetics data and bottom water properties. Early each morning, these data were processed and then provided to the Alvin observers prior to that same day's dive. ABE data were occasionally combined with, or supplanted by, data from the towed camera or the CTD. A total of 9 Alvin dives, 7 ABE dives, 5 camera tows and 6 CTD tows/casts were conducted. Detailed micro-bathymetric maps and mosaics of the vent communities will be presented.

  7. Academic Libraries and the Sciences: Assuring Successful Scholarship. Proceedings of a Program in Celebration of the 25th Anniversary of the University of California, Irvine and in Anticipation of Its New Science Library (Irvine, California, April 9, 1991).

    ERIC Educational Resources Information Center

    California Univ., Irvine.

    This document on successful scholarship in the sciences contains a keynote paper followed by six faculty responses. The keynote paper, delivered by Phillip Abelson of the American Association for the Advancement of Science (AAAS), is entitled "Assuring Successful Scholarship in the Sciences." Some of the factors likely to influence the nature of…

  8. Noninvasive Facial Rejuvenation. Part 3: Physician-Directed-Lasers, Chemical Peels, and Other Noninvasive Modalities.

    PubMed

    Meaike, Jesse D; Agrawal, Nikhil; Chang, Daniel; Lee, Edward I; Nigro, Marjory G

    2016-08-01

    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin and rejuvenate damaged skin. Physicians may recommend and often prescribe certain products, but patients are in control with this type of facial rejuvenation. On the other hand, physician-directed facial rejuvenation entails modalities that require direct physician involvement, such as neuromodulators, filler injections, laser resurfacing, microdermabrasion, and chemical peels. With the successful integration of each of these modalities, a complete facial regimen can be established and patient satisfaction can be maximized. This article is the last in a three-part series describing noninvasive facial rejuvenation. Here the authors review the mechanism, indications, and possible complications of lasers, chemical peels, and other commonly used noninvasive modalities. PMID:27478423

  9. Noninvasive Facial Rejuvenation. Part 2: Physician-Directed-Neuromodulators and Fillers.

    PubMed

    Dickey, Ryan M; Louis, Matthew R; Cox, Joshua A; Mohan, Kriti; Lee, Edward I; Nigro, Marjory G

    2016-08-01

    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin as well as rejuvenate damaged skin. Physicians may recommend and often prescribe certain products, but patients are in control with this type of facial rejuvenation. On the other hand, physician-directed facial rejuvenation entails modalities that require direct physician involvement, such as neuromodulators, filler injections, laser resurfacing, microdermabrasion, and chemical peels. With the successful integration of each of these modalities, a complete facial regimen can be established and patient satisfaction can be maximized. This article is the second in a three-part series describing noninvasive facial rejuvenation. Here the authors discuss neuromodulators and fillers in detail, focusing on indications for use, techniques, and common side effects. PMID:27478422

  10. Copious, Long-lived Rejuvenated Volcanism in the Northern Hawaiian Islands

    NASA Astrophysics Data System (ADS)

    Garcia, M. O.; Weis, D.; Hanano, D. W.; Jicha, B. R.; Ito, G.

    2015-12-01

    New marine surveying and submersible sampling of Kaul'a Volcano, located 100 km off the axis of the Hawaiian Chain, have revealed widespread areas of young volcanism. New 40Ar/39Ar and geochemical analyses of the olivine-phyric submarine and subaerial volcanic rocks show that Kaul'a is shrouded with young alkalic basalts (1.9 to 0.5 Ma). The ages and chemistry of these rocks overlap with rejuvenated lavas from nearby shields Ni'ihau, Kaua'i and South Kaua'i Swell. Collectively, rejuvenated lavas cover a vast area (~7000 km2) in the northern Hawaiian Islands. Kaul'a rejuvenated lavas show a much larger (5x) variation of incompatible elements than those from adjacent Ni'ihau but comparable to Honolulu rejuvenated lavas. Unlike both suites, heavy REE elements in Kaul'a lavas are pinned at Ybn 10, indicating a strong garnet signature in the source. Rejuvenated lavas from the Kaua'i Ridge have slightly higher radiogenic Pb isotope ratios than those from the southern Hawaiian Islands (Maui to O'ahu) and partly straddle the LOA-KEA boundary. Rejuvenated volcanism was nearly coeval occurrence from ~0.3 to 0.6 Ma along a 450 km segment of the Hawaiian Islands (West Maui to north of Ni'ihau), which is inconsistent with most models for rejuvenated volcanism except the Ballmer et al.2 dynamic melting model. This model invokes increasing pyroxenite contributions and the interaction with scale-scale convection rolls in the lithosphere to enhance the volume and duration of rejuvenation volcanism. Thus, a pyroxenite-bearing, mixed Kea-Loa source component may have contributed to the prolonged and extensive rejuvenated volcanism in the northern Hawaiian Islands. 1Robinson & Eakins 2006, J. Vol. Geotherm. Res., 151, 309-317; 2Ballmer et al. 2011, Nat. Geosc. 4, 457-460.

  11. Use of Aquamid as a filler for facial rejuvenation in orientals.

    PubMed

    Yagi, Yoichi; Kato, Kentaro; Murakami, Daisuke; Misaki, Kojiro; Ota, Mitsuya; Kataoka, Jiro; Yukawa, Naoki

    2009-10-01

    We used Aquamid as a filler for facial augmentation and rejuvenation in Orientals. This article introduces the injection techniques, effects, adequate dosage and complications of this filler, especially about rejuvenation of nasolabial fold and nasojugal groove. From December 2002 to June 2007, 5676 patients were treated in our clinic group. Complications were relatively minimal (0.082%) in comparison to other fillers and long-term effects were revealed. This is the first report concerning Aquamid use in facial rejuvenation of the Orientals. PMID:19303835

  12. Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells.

    PubMed

    Akunuru, Shailaja; Geiger, Hartmut

    2016-08-01

    Aging is associated with reduced organ function and increased disease incidence. Hematopoietic stem cell (HSC) aging driven by both cell intrinsic and extrinsic factors is linked to impaired HSC self-renewal and regeneration, aging-associated immune remodeling, and increased leukemia incidence. Compromised DNA damage responses and the increased production of reactive oxygen species (ROS) have been previously causatively attributed to HSC aging. However, recent paradigm-shifting concepts, such as global epigenetic and cytoskeletal polarity shifts, cellular senescence, as well as the clonal selection of HSCs upon aging, provide new insights into HSC aging mechanisms. Rejuvenating agents that can reprogram the epigenetic status of aged HSCs or senolytic drugs that selectively deplete senescent cells provide promising translational avenues for attenuating hematopoietic aging and, potentially, alleviating aging-associated immune remodeling and myeloid malignancies. PMID:27380967

  13. Facial rejuvenation starts in the midface: three-dimensional volumetric facial rejuvenation has beneficial effects on nontreated neighboring esthetic units.

    PubMed

    Wollina, Uwe

    2016-03-01

    Facial aging is a major indication for minimal invasive esthetic procedures. Dermal fillers are a cornerstone in the approach for facial sculpturing. But where to start? Our concept is midfacial volume restoration in first place. This will result in a healthy and youthful appearance creating a facial V-shape. But midfacial filler injection does not only improve the malar area. It has also beneficial effects on neighboring esthetic units. We report on such improvements in periocular and nasolabial region, upper lips and perioral tissue, and the jaw line and discuss anatomical background. We hypothesize that midfacial deep filler injections also may activate subdermal white adipose tissue stem cells contributing to longer lasting rejuvenation. PMID:26304759

  14. Study on Laser-Assisted Rejuvenation of Inter-Granular Corrosion Damaged Type 304 Stainless Steel

    NASA Astrophysics Data System (ADS)

    Gupta, R. K.; Bhardwaj, V. K.; Agrawal, D. K.; Kumar, Manoj; Upadhyay, B. N.; Sankar, P. Ram; Ganesh, P.; Kaul, R.; Oak, S. M.; Kukreja, L. M.

    2015-09-01

    The paper evaluates laser surface melting treatment for rejuvenation of inter-granular corrosion damaged type 304 stainless steel. Surface melting of inter-granular corrosion damaged specimens with CW CO2 and pulsed Nd:YAG lasers was quite effective in sealing surface damage. However, inter-granular corrosion susceptibility of laser-rejuvenated surface was strongly influenced by associated thermal exposure. With respect to CW CO2 laser, pulsed Nd:YAG laser-rejuvenated surface demonstrated significantly suppressed micro-structural damage and IGC-susceptibility. Compact pulsed Nd:YAG laser, with flexible beam transportation, presents an effective tool for in-situ rejuvenation of inter-granular corrosion damaged in-service stainless steel components operating in susceptible environments.

  15. Predicting gully rejuvenation after wildfire using remotely sensed burn severity data

    NASA Astrophysics Data System (ADS)

    Hyde, Kevin; Woods, Scott W.; Donahue, Jack

    2007-05-01

    The loss of surface vegetation and reduced infiltration caused by wildfires can trigger gully rejuvenation, resulting in damage to downstream aquatic resources and risk to human life and property. We developed a spatially explicit metric of burn severity — the Burn Severity Distribution Index (BSDI) — and tested its ability to predict post-fire gully rejuvenation in 1st and 2nd order basins burned in the 2000 Valley Complex fires in the Sapphire Mountains of western Montana. The BSDI was derived from burn severity data interpreted from Landsat 7 satellite imagery using the Normalized Burn Ratio (NBR) method, and ranged from 0.0 for completely unburned basins to 4.0 for basins burned entirely at high severity. In July 2001 rainstorms with peak 30-minute intensities of up to 17 mm h - 1 triggered gully rejuvenation in 66 of the 171 basins examined. The frequency of gully rejuvenation was higher in basins with higher BSDI values, increasing from zero for basins with a BSDI less than 1.3 to 67% for basins with a BSDI greater than 3.0. Binary logistic regression indicated that BSDI was a more significant predictor of gully rejuvenation than basin morphometric variables. The absence of gully rejuvenation in several basins with a high BSDI was attributed to low gradient, dense riparian vegetation, or concentration of high burn severity at lower elevations in the basin. The presence of gully rejuvenation in several basins with a low BSDI was associated with false negative NBR classification errors in northwest aspects, and concentration of severe burn impacts in the drainage headslopes. BSDI is a useful metric for predicting gully rejuvenation after wildfire. The use of the BSDI in Burned Area Emergency Response team assessments could improve the planning, implementation, and monitoring of burned area recovery treatments.

  16. 'Recharge my exhausted batteries': Overbeck's Rejuvenator, Patenting, and Public Medical Consumers, 1924-37.

    PubMed

    Stark, James F

    2014-10-01

    Although historians have shown that there has been a complex and multi-layered relationship between the body, medicine and the force of electricity, many avenues remain to be explored. One of the most prominent of these is the way in which electrotherapy technologies were marketed to a wide variety of different end users and intermediaries. This paper offers the first historical analysis of one such device - the Overbeck Rejuvenator - a 1920s electrotherapy machine designed for use by the general public. Its inventor, Otto Overbeck, was not a medical man and this enabled him to use aggressive strategies of newspaper advertising, using testimonials to market his product alongside appeals to his own scientific authority. He commissioned the prestigious Ediswan Company to manufacture the Rejuvenator on a large scale, and took out patents in eleven countries to persuade users of the efficacy of the device. In response to Overbeck's activities, the British Medical Association enlisted an electrical engineer to examine the Rejuvenator, contacted practitioners whose endorsements were being used in publicity material, and denied Overbeck permission to advertise in the British Medical Journal. Despite this, the Rejuvenator brought its inventor wealth and notoriety, and helped redefine the concept of 'rejuvenation', even if the professional reception of such a device was almost universally hostile. This paper shows how the marketing, patenting and publishing of Overbeck combined to persuade members of the laity to try the Rejuvenator as an alternative form of therapy, bypassing the medical profession in the process. PMID:25284892

  17. Preparation of capsules containing rejuvenators for their use in asphalt concrete.

    PubMed

    García, Alvaro; Schlangen, Erik; van de Ven, Martin; Sierra-Beltrán, Guadalupe

    2010-12-15

    Every year, there is a demand of more than 110 million metric tons of asphalt all around the world. This represents a huge amount of money and energy, from which a good part is for the preservation and renovation of the existing pavements. The problem of asphalt is that it oxidizes with time and therefore its beneficial properties disappear. Traditionally, rejuvenators spread in the road surface, are used to restore the original properties of the pavement. The problem is that, for a rejuvenator to be successful, it must penetrate the pavement surface. Furthermore, application of a rejuvenator will reduce the skid resistance of the pavement and, besides, rejuvenators have many aromatic compounds that can be harmful for the environment. To solve these problems this paper introduces a new concept in road construction: encapsulated rejuvenators. The basic principle is that when the stress in capsules embedded in the asphalt reaches a certain threshold value, the capsules break and some rejuvenator is released, restoring the original properties of the pavement. This paper will show how to prepare such capsules and how to determine their characteristics. This is one of the first steps towards intelligent pavements. PMID:20855160

  18. ESO 50th Anniversary Gala Dinner

    NASA Astrophysics Data System (ADS)

    Sirey, R.

    2012-12-01

    To formally mark the 50th anniversary of the signing of the ESO Convention, a gala dinner was held in the Munich Residenz. A brief report of the event is presented and the speeches are reproduced. The speakers were the President of the Council, Xavier Barcons; the German Minister for Education and Research, Prof. Dr Annette Schavan; the Bavarian State Minister for Science, Research and the Arts, Dr Wolfgang Heubisch; physics Nobel Laureate, Brian Schmidt; the current Director General, Tim de Zeeuw and the Chilean Minister of Foreign Affairs, Alfredo Moreno Charme.

  19. JANNAF 25th Airbreathing Propulsion Subcommittee, 37th Combustion Subcommittee and 1st Modeling and Simulation Subcommittee Joint Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Fry, Ronald S.; Becker, Dorothy L.

    2000-01-01

    Volume I, the first of three volumes, is a compilation of 24 unclassified/unlimited-distribution technical papers presented at the Joint Army-Navy-NASA-Air Force (JANNAF) 25th Airbreathing Propulsion Subcommittee, 37th Combustion Subcommittee and 1st Modeling and Simulation Subcommittee (MSS) meeting held jointly with the 19th Propulsion Systems Hazards Subcommittee. The meeting was held 13-17 November 2000 at the Naval Postgraduate School and Hyatt Regency Hotel, Monterey, California. Topics covered include: a Keynote Address on Future Combat Systems, a review of the new JANNAF Modeling and Simulation Subcommittee, and technical papers on Hyper-X propulsion development and verification; GTX airbreathing launch vehicles; Hypersonic technology development, including program overviews, fuels for advanced propulsion, ramjet and scramjet research, hypersonic test medium effects; and RBCC engine design and performance, and PDE and UCAV advanced and combined cycle engine technologies.

  20. Rejuvenation of the lithosphere by the Hawaiian plume.

    PubMed

    Li, Xueqing; Kind, Rainer; Yuan, Xiaohui; Wölbern, Ingo; Hanka, Winfried

    2004-02-26

    The volcanism responsible for creating the chain of the Hawaiian islands and seamounts is believed to mark the passage of the oceanic lithosphere over a mantle plume. In this picture hot material rises from great depth within a fixed narrow conduit to the surface, penetrating the moving lithosphere. Although a number of models describe possible plume-lithosphere interactions, seismic imaging techniques have not had sufficient resolution to distinguish between them. Here we apply the S-wave 'receiver function' technique to data of three permanent seismic broadband stations on the Hawaiian islands, to map the thickness of the underlying lithosphere. We find that under Big Island the lithosphere is 100-110 km thick, as expected for an oceanic plate 90-100 million years old that is not modified by a plume. But the lithosphere thins gradually along the island chain to about 50-60 km below Kauai. The width of the thinning is about 300 km. In this zone, well within the larger-scale topographic swell, we infer that the rejuvenation model (where the plume thins the lithosphere) is operative; however, the larger-scale topographic swell is probably supported dynamically. PMID:14985758

  1. On interstellar accretion and the rejuvenation of white dwarfs

    NASA Technical Reports Server (NTRS)

    Truran, J. W.; Wyatt, S. P.; Starrfield, S. G.; Strittmatter, P. A.; Sparks, W. M.

    1977-01-01

    The paper investigates physical conditions which can give rise to thermonuclear runaways in the hydrogen envelopes of low-luminosity white dwarfs. Specifically, calculations are performed for white dwarfs of 0.5, 0.75, 1, and 1.25 solar masses with envelope masses in the range from 0.00001 to 0.001 solar mass and initial luminosities of 0.00001 to 0.01 times the solar value. It is found that envelope masses as low as 0.0001 solar mass are sufficient to initiate thermonuclear runaways on more massive white dwarfs with luminosities as low as about 0.001 the solar value. The runaway time scales under these conditions, typically of the order of a billion years, are comparable to the time scales for cooling of white dwarfs to these low luminosities. Since time-averaged accretion rates as low as a few times 10 to the -14th power solar mass per year are sufficient to reconstitute such envelopes, also on a time scale of several billion years, it is suggested that the association of novalike events with binary systems may not be unique. Accretion of interstellar matter onto isolated white dwarfs may, under some circumstances, be sufficient to rekindle and perhaps rejuvenate the dwarf. Such evolutionary behavior might define a new and distinct class of objects.

  2. The rejuvenating effect of pregnancy on muscle regeneration

    PubMed Central

    Falick Michaeli, Tal; Laufer, Neri; Sagiv, Jitka Yehudit; Dreazen, Avigail; Granot, Zvi; Pikarsky, Eli; Bergman, Yehudit; Gielchinsky, Yuval

    2015-01-01

    Aging is characterized by reduced tissue regenerative capacity attributed to a diminished responsiveness of tissue-specific stem cells. With increasing age, resident precursor cells in muscle tissues show a markedly impaired propensity to proliferate in response to damage. However, exposure to factors present in the serum of young mice restores the regenerative capacity of aged precursor cells. As pregnancy represents a unique biological model of a partially shared blood system between young and old organisms, we hypothesized that pregnancy in aged mice would have a rejuvenating effect on the mother. To test this hypothesis, we assessed muscle regeneration in response to injury in young and aged pregnant and nonpregnant mice. Muscle regeneration in the aged pregnant mice was improved relative to that in age-matched nonpregnant mice. The beneficial effect of pregnancy was transient, lasting up to 2 months after delivery, and appeared to be attributable to activation of satellite cells via the Notch signaling pathway, thus supporting the possibility that pregnancy induces activation of aged dormant muscle progenitor cells. PMID:25773509

  3. Scientific overview of hormone treatment used for rejuvenation.

    PubMed

    Morley, John E

    2013-06-01

    A search for a hormonal fountain of youth has been hotly pursued over the last century, predominately by those who wish to market hormones to a gullible public. There is little or no benefit of hormone replacement in persons who do not have a hormone deficiency. Overall, the present state of the art suggests that the findings have been disappointing. In persons who fail to get adequate sunlight, and therefore have low vitamin D levels, vitamin D replacement appears to have positive effects, including decreasing mortality. Testosterone in hypogonadal males has a number of positive effects such as improving libido and erectile capacity, increasing strength and bone mineral density, and perhaps having a small effect on cognition. These effects need to be balanced against long-term side effects, the evidence for which studies are lacking. There is little evidence to recommend DHEA, pregnenolone, growth hormone, ghrelin, or melatonin to older persons. Overall, exercise, adequate exposure to sunlight, and adequate dietary protein appear to have at least as positive an effect as any of the hormones being used to rejuvenate older persons. PMID:23726254

  4. Logging system adds value to field rejuvenation efforts

    SciTech Connect

    Peters, D.; Bartenhagen, K.; Santolamazza, A.

    1997-11-01

    As with any rejuvenation scheme, the first step is always identification and evaluation of potential producible reserves. But economic and physical factors made evaluation using traditional logging techniques problematic. The constraints that inhibited earlier logging tools have been addressed by a new, compact integrated system called Platform Express (PEX). Oil companies operating in two of the most mature producing regions of the US, the Hugoton-Panhandle Field and the Southwest Nena Lucia Field in West Texas, discuss the physical and economic advantages they are reaping using PEX technologies. Hugoton-Panhandle Field, discovered around 1920, sprawls across parts of three south-central states and has been one of the world`s largest gas producers. Despite continuing pressure declines in this aging gas giant, the entire region has undergone restoration in the last few years. In its Kansas portions, a modest oil production has almost doubled since 1990 and a steep gas decline has been completely turned around. These production gains have come from an active program of recompletions, the deepening of old holes and new drilling. The story in the southwest Nena Lucia Field is much the same. Operator Oryx Energy has been active in the field, located west of Abilene, Texas, since its discovery in the 1950s. The goal with this field is to use advanced technologies to reverse the production declines that began years ago. Such a reversal began in mid-1996 and has been sustained thus far.

  5. Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria.

    PubMed

    Agrawal, Anurag; Mabalirajan, Ulaganathan

    2016-01-15

    Altered bioenergetics with increased mitochondrial reactive oxygen species production and degradation of epithelial function are key aspects of pathogenesis in asthma and chronic obstructive pulmonary disease (COPD). This motif is not unique to obstructive airway disease, reported in related airway diseases such as bronchopulmonary dysplasia and parenchymal diseases such as pulmonary fibrosis. Similarly, mitochondrial dysfunction in vascular endothelium or skeletal muscles contributes to the development of pulmonary hypertension and systemic manifestations of lung disease. In experimental models of COPD or asthma, the use of mitochondria-targeted antioxidants, such as MitoQ, has substantially improved mitochondrial health and restored respiratory function. Modulation of noncoding RNA or protein regulators of mitochondrial biogenesis, dynamics, or degradation has been found to be effective in models of fibrosis, emphysema, asthma, and pulmonary hypertension. Transfer of healthy mitochondria to epithelial cells has been associated with remarkable therapeutic efficacy in models of acute lung injury and asthma. Together, these form a 3R model--repair, reprogramming, and replacement--for mitochondria-targeted therapies in lung disease. This review highlights the key role of mitochondrial function in lung health and disease, with a focus on asthma and COPD, and provides an overview of mitochondria-targeted strategies for rejuvenating cellular respiration and optimizing respiratory function in lung diseases. PMID:26566906

  6. The Impracticality of Biomedical Rejuvenation Therapies: Translational and Pharmacological Barriers

    PubMed Central

    2014-01-01

    Abstract Editor's Note: A response to this article from Aubrey de Grey, Editor-in-Chief, can be found on pages 397–400 in this issue. The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical “repair-oriented” approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the final result impossible to predict. Two relatively easy-to-research areas are the search for successful cross-link breakers and an effective lysosomal degradation therapy. A more complex and speculative strategy is whole-body interdiction of lengthening of telomeres (WILT). Highlighting these as examples, I argue that it is unlikely that such rejuvenation biotechnologies will be used meaningfully by the general public. The discussion assumes that although such therapies may in theory one day be developed in the laboratory, and even possibly be formulated as physical clinical therapies, these will be unusable in practical terms when applied upon humans at large. Due to inherent characteristics of our biological, evolutionary, and psychological heritage, it is implausible that curing aging will occur by using physical interventions alone. PMID:25072550

  7. The impracticality of biomedical rejuvenation therapies: translational and pharmacological barriers.

    PubMed

    Kyriazis, Marios

    2014-08-01

    The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical "repair-oriented" approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the final result impossible to predict. Two relatively easy-to-research areas are the search for successful cross-link breakers and an effective lysosomal degradation therapy. A more complex and speculative strategy is whole-body interdiction of lengthening of telomeres (WILT). Highlighting these as examples, I argue that it is unlikely that such rejuvenation biotechnologies will be used meaningfully by the general public. The discussion assumes that although such therapies may in theory one day be developed in the laboratory, and even possibly be formulated as physical clinical therapies, these will be unusable in practical terms when applied upon humans at large. Due to inherent characteristics of our biological, evolutionary, and psychological heritage, it is implausible that curing aging will occur by using physical interventions alone. PMID:25072550

  8. Clinical Study of the Necessity of Replanning Before the 25th Fraction During the Course of Intensity-Modulated Radiotherapy for Patients With Nasopharyngeal Carcinoma

    SciTech Connect

    Wang Wei; Yang Haihua; Hu Wei; Shan Guoping; Ding Weijun; Yu Changhui; Wang Biyun; Wang Xufeng; Xu Qianyi

    2010-06-01

    Purpose: To quantify the target and normal structures on dose distributing variations during intensity-modulated radiotherapy (IMRT) and to assess the value of replanning for nasopharyngeal carcinoma (NPC) patients. Methods and Materials: Twenty-eight NPC patients treated with IMRT were recruited. The IMRT was delivered in 33 fractions, to 70 to 76Gy, to the gross tumor volume (GTV). Before the 25th fraction of IMRT, a new simulation computed tomography (CT) scan was acquired for all patients. According to the dose constraint criterion in the Radiation Therapy Oncology Group (RTOG) 0225 protocol, the replanning was generated on the new simulation CT. With the Quality Assessment Center of a CORVUS 6.3 treatment planning system, a phantom plan was generated for each patient by applying the beam configurations of the initial plan to the anatomy of the new simulation CT. The dose-volume histograms of the phantom plan were compared with the replanning. Results: The percentage of prescription dose delivered to the clinical target volume (CTV1) was significantly increased by 4.91% +- 10.89%, whereas the maximum dose to the spinal cord, mean dose to the left parotid, and V30 to the right parotid were significantly decreased by 5.00 +- 9.23Gy, 4.23 +- 10.03Gy, and 11.47% +- 18.89% respectively in the replanning, compared with the phantom plan (p < 0.05). Based on the dose constraint criterion in the RTOG0225 protocol, 50% of phantom plans (14/28) were out of limit for the dose to the normal critical structures, whereas no plan was out of limit in replanning (p < 0.001). Conclusion: Replanning for patients with NPC before the 25th fraction during IMRT helps to ensure adequate dose to the target volumes and safe doses to critical normal structures.

  9. Proteomic profiling of proteins associated with the rejuvenation of Sequoia sempervirens (D. Don) Endl

    PubMed Central

    2010-01-01

    Background Restoration of rooting competence is important for rejuvenation in Sequoia sempervirens (D. Don) Endl and is achieved by repeatedly grafting Sequoia shoots after 16 and 30 years of cultivation in vitro. Results Mass spectrometry-based proteomic analysis revealed three proteins that differentially accumulated in different rejuvenation stages, including oxygen-evolving enhancer protein 2 (OEE2), glycine-rich RNA-binding protein (RNP), and a thaumatin-like protein. OEE2 was found to be phosphorylated and a phosphopeptide (YEDNFDGNSNVSVMVpTPpTDK) was identified. Specifically, the protein levels of OEE2 increased as a result of grafting and displayed a higher abundance in plants during the juvenile and rejuvenated stages. Additionally, SsOEE2 displayed the highest expression levels in Sequoia shoots during the juvenile stage and less expression during the adult stage. The expression levels also steadily increased during grafting. Conclusion Our results indicate a positive correlation between the gene and protein expression patterns of SsOEE2 and the rejuvenation process, suggesting that this gene is involved in the rejuvenation of Sequoia sempervirens. PMID:21143964

  10. Investigation of the possibility of using waste cooking oil as a rejuvenating agent for aged bitumen.

    PubMed

    Zargar, Majid; Ahmadinia, Esmaeil; Asli, Hallizza; Karim, Mohamed Rehan

    2012-09-30

    The ageing of the bitumen during storage, mixing, transport and laying on the road, as well as in service life, are the most important problems presented by the use of bitumen in pavements. This paper investigates the possibility of using waste cooking oil (WCO), which is a waste material that pollutes landfills and rivers, as an alternative natural rejuvenating agent for aged bitumen to a condition that resembles the original bitumen. With this target, the physical and chemical properties of the original bitumen, aged bitumen and rejuvenated bitumen were measured and compared by the bitumen binder tests - softening point, penetration, Brookfield viscosity, dynamic shear rheometer and Fourier transform infrared spectroscopy. In addition, the behaviour of the WCO rejuvenated bitumen is investigated and compared with virgin bitumen after using the rolling thin film oven ageing process. In general, the results showed that using 3-4% of WCO the aged bitumen group 40/50 was rejuvenated to a condition that closely resembled the physical, rheological properties of the original bitumen (80/100), however, there was a difference in the tendency to ageing between the WCO rejuvenated bitumen and the virgin bitumen during mixing, transport and laying on the road. PMID:22818590

  11. Rejuvenating Hydrator: Restoring Epidermal Hyaluronic Acid Homeostasis With Instant Benefits.

    PubMed

    Narurkar, Vic A; Fabi, Sabrina G; Bucay, Vivian W; Tedaldi, Ruth; Downie, Jeanine B; Zeichner, Joshua A; Butterwick, Kimberly; Taub, Amy; Kadoya, Kuniko; Makino, Elizabeth T; Mehta, Rahul C; Vega, Virginia L

    2016-01-01

    Skin aging is a combination of multifactorial mechanisms that are not fully understood. Intrinsic and extrinsic factors modulate skin aging, activating distinctive processes that share similar molecular pathways. One of the main characteristics of youthful skin is its large capacity to retain water, and this decreases significantly as we age. A key molecule involved in maintaining skin hydration is hyaluronic acid (HA). Concentration of HA in the skin is determined by the complex balance between its synthesis, deposition, association with cellular structures, and degradation. HA bio-equivalency and bio-compatibility have been fundamental in keeping this macromolecule as the favorite of the skincare industry for decades. Scientific evidence now shows that topically applied HA is unable to penetrate the skin and is rapidly degraded on the skin surface. SkinMedica's HA5 Rejuvenating Hydrator (SkinMedica Inc., an Allergan company, Irvine, CA) promotes restoration of endogenous epidermal HA homeostasis and provides instant smoothing and hydration of the skin. These dual benefits are accomplished through the combination of 2 breakthrough technologies: 1) a unique blend of actives powered by SkinMedica proprietary flower-derived stem cell extract that restores the endogenous production of HA; and 2) a proprietary mix of 5 HA forms that plump the skin, decreasing the appearance of fine lines/wrinkles. Pre-clinical studies demonstrated that HA5 induces expression of key epidermal differentiation and barrier markers as well as epidermal HA synthases. A decrease expression of hyaluronidases was also observed upon HA5 application. Initial clinical studies showed that within 15 minutes of application, HA5 instantly improves the appearance of fine lines/wrinkles and skin hydration. Subjects that continue using HA5 (for 8 weeks) demonstrated significant improvements in fine lines/wrinkles, tactile roughness, and skin hydration. In summary, the blend of these 2 key technologies

  12. Rejuvenation of metallic glasses by non-affine thermal strain.

    PubMed

    Ketov, S V; Sun, Y H; Nachum, S; Lu, Z; Checchi, A; Beraldin, A R; Bai, H Y; Wang, W H; Louzguine-Luzgin, D V; Carpenter, M A; Greer, A L

    2015-08-13

    When a spatially uniform temperature change is imposed on a solid with more than one phase, or on a polycrystal of a single, non-cubic phase (showing anisotropic expansion-contraction), the resulting thermal strain is inhomogeneous (non-affine). Thermal cycling induces internal stresses, leading to structural and property changes that are usually deleterious. Glasses are the solids that form on cooling a liquid if crystallization is avoided--they might be considered the ultimate, uniform solids, without the microstructural features and defects associated with polycrystals. Here we explore the effects of cryogenic thermal cycling on glasses, specifically metallic glasses. We show that, contrary to the null effect expected from uniformity, thermal cycling induces rejuvenation, reaching less relaxed states of higher energy. We interpret these findings in the context that the dynamics in liquids become heterogeneous on cooling towards the glass transition, and that there may be consequent heterogeneities in the resulting glasses. For example, the vibrational dynamics of glassy silica at long wavelengths are those of an elastic continuum, but at wavelengths less than approximately three nanometres the vibrational dynamics are similar to those of a polycrystal with anisotropic grains. Thermal cycling of metallic glasses is easily applied, and gives improvements in compressive plasticity. The fact that such effects can be achieved is attributed to intrinsic non-uniformity of the glass structure, giving a non-uniform coefficient of thermal expansion. While metallic glasses may be particularly suitable for thermal cycling, the non-affine nature of strains in glasses in general deserves further study, whether they are induced by applied stresses or by temperature change. PMID:26268190

  13. Rejuvenating Muscle Stem Cell Function: Restoring Quiescence and Overcoming Senescence.

    PubMed

    Mendelsohn, Andrew R; Larrick, James W

    2016-04-01

    Elderly humans gradually lose strength and the capacity to repair skeletal muscle. Skeletal muscle repair requires functional skeletal muscle satellite (or stem) cells (SMSCs) and progenitor cells. Diminished stem cell numbers and increased dysfunction correlate with the observed gradual loss of strength during aging. Recent reports attribute the loss of stem cell numbers and function to either increased entry into a presenescent state or the loss of self-renewal capacity due to an inability to maintain quiescence resulting in stem cell exhaustion. Earlier work has shown that exposure to factors from blood of young animals and other treatments could restore SMSC function. However, cells in the presenescent state are refractory to the beneficial effects of being transplanted into a young environment. Entry into the presenescent state results from loss of autophagy, leading to increased ROS and epigenetic modification at the CDKN2A locus due to decreased H2Aub, upregulating cell senescence biomarker p16ink4a. However, the presenescent SMSCs can be rejuvenated by agents that stimulate autophagy, such as the mTOR inhibitor rapamycin. Autophagy plays a critical role in SMSC homeostasis. These results have implications for the development of senolytic therapies that attempt to destroy p16ink4a expressing cells, since such therapies would also destroy a reservoir of potentially rescuable regenerative stem cells. Other work suggests that in humans, loss of SMSC self-renewal capacity is primarily due to decreased expression of sprouty1. DNA hypomethylation at the SPRY1 gene locus downregulates sprouty1, causing inability to maintain quiescence and eventual exhaustion of the stem cell population. A unifying hypothesis posits that in aging humans, first loss of quiescence occurs, depleting the stem cell population, but that remaining SMSCs are increasingly subject to presenescence in the very old. PMID:27000748

  14. Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

    PubMed Central

    Vazquez-Martin, Alejandro; Van den Haute, Chris; Cufí, Sílvia; Corominas-Faja, Bruna; Cuyàs, Elisabet; Lopez-Bonet, Eugeni; Rodriguez-Gallego, Esther; Fernández-Arroyo, Salvador; Joven, Jorge; Baekelandt, Veerle; Menendez, Javier A.

    2016-01-01

    Our understanding on how selective mitochondrial autophagy, or mitophagy, can sustain the archetypal properties of stem cells is incomplete. PTEN-induced putative kinase 1 (PINK1) plays a key role in the maintenance of mitochondrial morphology and function and in the selective degradation of damaged mitochondria by mitophagy. Here, using embryonic fibroblasts from PINK1 gene-knockout (KO) mice, we evaluated whether mitophagy is a causal mechanism for the control of cell-fate plasticity and maintenance of pluripotency. Loss of PINK1-dependent mitophagy was sufficient to dramatically decrease the speed and efficiency of induced pluripotent stem cell (iPSC) reprogramming. Mitophagy-deficient iPSC colonies, which were characterized by a mixture of mature and immature mitochondria, seemed unstable, with a strong tendency to spontaneously differentiate and form heterogeneous populations of cells. Although mitophagy-deficient iPSC colonies normally expressed pluripotent markers, functional monitoring of cellular bioenergetics revealed an attenuated glycolysis in mitophagy-deficient iPSC cells. Targeted metabolomics showed a notable alteration in numerous glycolysis- and TCA-related metabolites in mitophagy-deficient iPSC cells, including a significant decrease in the intracellular levels of α-ketoglutarate -a key suppressor of the differentiation path in stem cells. Mitophagy-deficient iPSC colonies exhibited a notably reduced teratoma-initiating capacity, but fully retained their pluripotency and multi-germ layer differentiation capacity in vivo. PINK1-dependent mitophagy pathway is an important mitochondrial switch that determines the efficiency and quality of somatic reprogramming. Mitophagy-driven mitochondrial rejuvenation might contribute to the ability of iPSCs to suppress differentiation by directing bioenergetic transition and metabolome remodeling traits. These findings provide new insights into how mitophagy might influence the stem cell decisions to retain

  15. Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate.

    PubMed

    Vazquez-Martin, Alejandro; Van den Haute, Chris; Cufí, Sílvia; Corominas-Faja, Bruna; Cuyàs, Elisabet; Lopez-Bonet, Eugeni; Rodriguez-Gallego, Esther; Fernández-Arroyo, Salvador; Joven, Jorge; Baekelandt, Veerle; Menendez, Javier A

    2016-07-01

    Our understanding on how selective mitochondrial autophagy, or mitophagy, can sustain the archetypal properties of stem cells is incomplete. PTEN-induced putative kinase 1 (PINK1) plays a key role in the maintenance of mitochondrial morphology and function and in the selective degradation of damaged mitochondria by mitophagy. Here, using embryonic fibroblasts fromPINK1 gene-knockout (KO) mice, we evaluated whether mitophagy is a causal mechanism for the control of cell-fate plasticity and maintenance of pluripotency. Loss of PINK1-dependent mitophagy was sufficient to dramatically decrease the speed and efficiency of induced pluripotent stem cell (iPSC) reprogramming. Mitophagy-deficient iPSC colonies, which were characterized by a mixture of mature and immature mitochondria, seemed unstable, with a strong tendency to spontaneously differentiate and form heterogeneous populations of cells. Although mitophagy-deficient iPSC colonies normally expressed pluripotent markers, functional monitoring of cellular bioenergetics revealed an attenuated glycolysis in mitophagy-deficient iPSC cells. Targeted metabolomics showed a notable alteration in numerous glycolysis- and TCA-related metabolites in mitophagy-deficient iPSC cells, including a significant decrease in the intracellular levels of α-ketoglutarate -a key suppressor of the differentiation path in stem cells. Mitophagy-deficient iPSC colonies exhibited a notably reduced teratoma-initiating capacity, but fully retained their pluripotency and multi-germ layer differentiation capacity in vivo. PINK1-dependent mitophagy pathway is an important mitochondrial switch that determines the efficiency and quality of somatic reprogramming. Mitophagy-driven mitochondrial rejuvenation might contribute to the ability of iPSCs to suppress differentiation by directing bioenergetic transition and metabolome remodeling traits. These findings provide new insights into how mitophagy might influence the stem cell decisions to retain

  16. Ceremony 25th birthday Cern

    SciTech Connect

    2006-05-08

    Célébration du 25ème anniversaire du Cern (jour par jour) avec discours de L.Van Hove et J.B.Adams, des interludes musicals offerts par Mme Mey et ses collègues (au debut 1.mouvement du quatuor avec piano no 3 de L.van Beethoven) Les directeurs généraux procéderont à la remise du souvenir aux membres de personnel ayant 25 années de service dans l'organisation. Un témoignage de reconnaissance est auss fait à l'interprète Mme Zwerner

  17. 25th Birthday Cern- Restaurant

    ScienceCinema

    None

    2011-04-25

    Cérémonie du 25ème anniversaire du Cern avec plusieurs orateurs et la présence de nombreux autorités cantonales et communales genevoises et personnalités, directeurs généraux, ministres, chercheurs.... Le conseiller féderal et chef du département des affaires étrangères de la confédération Monsieur Pierre Aubert prend la parole pour célébrer à la fois les résultats très remarquables de la coopération internationale en matière scientifique, mais aussi la volonté politique des états européens de mettre en commun leurs ressources pour faire oeuvre d'avenir. Un grand hommage est aussi donné aux deux directeurs disparus, les prof.Bakker et Gregory.

  18. 25th Birthday Cern- Amphi

    ScienceCinema

    None

    2011-04-25

    Cérémonie du 25ème anniversaire du Cern avec 2 orateurs: le Prof.Weisskopf parle de la signification et le rôle du Cern et le Prof.Casimir(?) fait un exposé sur les rélations entre la science pure et la science appliquée et la "big science" (science légère)

  19. Ceremony 25th birthday Cern

    ScienceCinema

    None

    2011-04-25

    Célébration du 25ème anniversaire du Cern (jour par jour) avec discours de L.Van Hove et J.B.Adams, des interludes musicals offerts par Mme Mey et ses collègues (au debut 1.mouvement du quatuor avec piano no 3 de L.van Beethoven) Les directeurs généraux procéderont à la remise du souvenir aux membres de personnel ayant 25 années de service dans l'organisation. Un témoignage de reconnaissance est auss fait à l'interprète Mme Zwerner

  20. The reinforcement and healing of asphalt mastic mixtures by rejuvenator encapsulation in alginate compartmented fibres

    NASA Astrophysics Data System (ADS)

    Tabaković, A.; Post, W.; Cantero, D.; Copuroglu, O.; Garcia, S. J.; Schlangen, E.

    2016-08-01

    This paper explores the potential use of compartmented alginate fibres as a new method of incorporating rejuvenators into asphalt pavement mixtures. The compartmented fibres are employed to locally distribute the rejuvenator and to overcome the problems associated with spherical capsules and hollow fibres. The work presents proof of concept of the encapsulation process which involved embedding the fibres into the asphalt mastic mixture and the survival rate of fibres in the asphalt mixture. To prove the effectiveness of the alginate as a rejuvenator encapsulating material and to demonstrate its ability survive asphalt production process, the fibres containing the rejuvenator were prepared and subjected to thermogravimetric analysis and uniaxial tensile test. The test results demonstrated that fibres have suitable thermal and mechanical strength to survive the asphalt mixing and compaction process. The CT scan of an asphalt mortar mix containing fibres demonstrated that fibres are present in the mix in their full length, undamaged, providing confirmation that the fibres survived the asphalt production process. In order to investigate the fibres physiological properties and ability to release the rejuvenator into cracks in the asphalt mastic, the environmental scanning electron microscope and optical microscope analysis were employed. To prove its success as an asphalt healing system, compartmented alginate fibres containing rejuvenator were embedded in asphalt mastic mix. The three point bend tests were performed on the asphalt mastic test samples and the degree to which the samples began to self-heal in response was measured and quantified. The research findings indicate that alginate fibres present a promising new approach for the development of self-healing asphalt pavement systems.

  1. Views of the Apollo 11 Twentieth Anniversary Black Tie reception

    NASA Technical Reports Server (NTRS)

    1989-01-01

    View from the Apollo 11 Twentieth Anniversary Black Tie reception at the downtown Houston Hyatt Regency Hotel. Scene show NASA/JSC Director Aaron Cohen talking with NASA Administrator Richard H. Truly and his wife, Cody.

  2. Administrator Bolden Talks to Station Crew on 10th Anniversary

    NASA Video Gallery

    NASA Administrator Charlie Bolden talks with the Expedition 25 crew on board the International Space Station on November 2, marking the tenth anniversary of continuous human presence on the orbitin...

  3. 158. View looking SE showing 'Centennial Anniversary of the Declaration ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    158. View looking SE showing 'Centennial Anniversary of the Declaration of Independence' fountain on Aquarium Drive with north facade of Art Museum in right background. - Fairmount Waterworks, East bank of Schuylkill River, Aquarium Drive, Philadelphia, Philadelphia County, PA

  4. Comprehensive periorbital rejuvenation with resorbable endotine implants for trans-lid brow and midface elevation.

    PubMed

    Sclafani, Anthony P

    2007-05-01

    Periorbital rejuvenation can enhance a patient's appearance, with changes of only a few millimeters making a significant impact. Many patients undergoing blepharoplasty often have mild brow or midfacial changes for which they are unwilling to undergo additional concurrent forehead or midface procedures, however, because these procedures may be associated with an unacceptable postoperative recovery and may not provide adequate tissue fixation. This article describes limited incision procedures capable of providing excellent elevation and support to the brow and midface that can be incorporated easily into a comprehensive periorbital rejuvenation treatment plan using semi-permanent subperiosteal fixation devices. PMID:17544943

  5. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong poses for a photograph with fans who attended the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

  6. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong talks with a former Apollo team member during an anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

  7. Preparation and Characterization of a Monoclonal Antibody Against the Core Protein VP7 of the 25th Serotype of Bluetongue Virus

    PubMed Central

    Wu, Xiao; Liu, Qi; He, Jia; Zang, Mingxin; Wang, Haixiu; Li, Yijing

    2015-01-01

    Bluetongue virus (BTV) is a member of the genus Orbivirus, within the family Reoviridae. The VP7 protein of BTV is used for developing group-specific serological assays. To prepare monoclonal antibody (MAb) against VP7 of the 25th serotype BTV, the RNA S7 encoding VP7 was cloned into prokaryotic expression vectors pET-28a (+) and pGEX-6P-1 to generate recombinant plasmids. The recombinant protein VP7 was expressed in Escherichia coli BL21 (DE3), respectively. The results of SDS-PAGE revealed that the VP7 was expressed and the molecular mass of recombinant fusion protein pET-28a (+)/VP7 and pGEX-6P-1/VP7 was approximately 44 kDa and 64 kDa, respectively. The Western blot analysis indicated that the recombinant VP7 possessed good immunoreactivity. After purification, pET-28a (+)/VP7 was used to immunize BALB/c mice, while pGEX-6P-1/VP7 was used to screen for well-to-well MAb-secreting hybridomas. The hybridoma cell line 3H7 against recombinant VP7 that secreted MAbs was obtained. The isotype of 3H7 was identified as IgG1. The purification of recombinant VP7 protein and the monoclonal antibody will have potential applications on competitive ELISA format for BT-specific serum detection method. PMID:25897610

  8. Preparation and Characterization of a Monoclonal Antibody Against the Core Protein VP7 of the 25th Serotype of Bluetongue Virus.

    PubMed

    Wu, Xiao; Liu, Qi; He, Jia; Zang, Mingxin; Wang, Haixiu; Li, Yijing; Tang, Lijie

    2015-04-01

    Bluetongue virus (BTV) is a member of the genus Orbivirus, within the family Reoviridae. The VP7 protein of BTV is used for developing group-specific serological assays. To prepare monoclonal antibody (MAb) against VP7 of the 25th serotype BTV, the RNA S7 encoding VP7 was cloned into prokaryotic expression vectors pET-28a (+) and pGEX-6P-1 to generate recombinant plasmids. The recombinant protein VP7 was expressed in Escherichia coli BL21 (DE3), respectively. The results of SDS-PAGE revealed that the VP7 was expressed and the molecular mass of recombinant fusion protein pET-28a (+)/VP7 and pGEX-6P-1/VP7 was approximately 44 kDa and 64 kDa, respectively. The Western blot analysis indicated that the recombinant VP7 possessed good immunoreactivity. After purification, pET-28a (+)/VP7 was used to immunize BALB/c mice, while pGEX-6P-1/VP7 was used to screen for well-to-well MAb-secreting hybridomas. The hybridoma cell line 3H7 against recombinant VP7 that secreted MAbs was obtained. The isotype of 3H7 was identified as IgG1. The purification of recombinant VP7 protein and the monoclonal antibody will have potential applications on competitive ELISA format for BT-specific serum detection method. PMID:25897610

  9. Combination visible and infrared lasers for skin rejuvenation.

    PubMed

    Lee, Min-Wei Christine

    2002-12-01

    Noninvasive techniques for skin rejuvenation are quickly being established as a new standard in the treatment of mild rhytides and overall skin toning. Multiple laser wavelengths and modalities have been tried for this procedure with varying degrees of success. These lasers include 532 nm, 585 nm, 1064 nm, 1320 nm, 1450 nm, and 1540 nm wavelengths. This study evaluates a combination technique by using a long-pulsed 532 nm potassium titanyl phosphate (KTP) laser and a long-pulsed 1064 nm Neodynium:yttrium aluminum garnet (Nd:YAG) laser, both separately and combined, for noninvasive photorejuvenation and skin toning/collagen enhancement, and establishes efficacy and degree of success. A total of 150 patients were treated with the long-pulsed KTP 532 nm (Aura; Laserscope, San Jose, CA) and long-pulsed Nd:YAG 1064 nm (Lyra; Laserscope) lasers both separately and combined. Patients included skin types I through V. The fluences varied between 7 and 15 J/cm2 at 7 to 20 ms pulse duration with a 2-mm handpiece, and 6 to 15 J/cm2 and 30 to 50 ms with a 4-mm handpiece for KTP. The Nd:YAG fluences were set at 24 to 30 J/cm2 for a 10-mm handpiece and 30 J/cm2 for a SmartScan Plus scanner (Laserscope, San Jose, CA). These energies were delivered at 30 to 65 ms pulse durations. All patients were treated at least 3 times and at most 6 times at monthly intervals, and were observed for up to 18 months after the last treatment. All 150 patients exhibited a mild to moderate degree of improvement in the appearance of rhytides, moderate degree of improvement in skin toning and texture, and great improvement in the reduction of redness and pigmentation. The KTP used alone was superior to the Nd:YAG laser in terms of results. The KTP and Nd:YAG laser combination was superior to either laser used alone. PMID:12512652

  10. Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin

    PubMed Central

    Baht, Gurpreet S.; Silkstone, David; Vi, Linda; Nadesan, Puviindran; Amani, Yasha; Whetstone, Heather; Wei, Qingxia; Alman, Benjamin A.

    2015-01-01

    The capacity for tissues to repair and regenerate diminishes with age. We sought to determine the age-dependent contribution of native mesenchymal cells and circulating factors on in vivo bone repair. Here we show that exposure to youthful circulation by heterochronic parabiosis reverses the aged fracture repair phenotype and the diminished osteoblastic differentiation capacity of old animals. This rejuvenation effect is recapitulated by engraftment of young haematopoietic cells into old animals. During rejuvenation, β-catenin signalling, a pathway important in osteoblast differentiation, is modulated in the early repair process and required for rejuvenation of the aged phenotype. Temporal reduction of β-catenin signalling during early fracture repair improves bone healing in old mice. Our data indicate that young haematopoietic cells have the capacity to rejuvenate bone repair and this is mediated at least in part through β-catenin, raising the possibility that agents that modulate β-catenin can improve the pace or quality of fracture repair in the ageing population. PMID:25988592

  11. Assessment of the aging level of rejuvenated hot mixed asphalt concrete pavements

    NASA Astrophysics Data System (ADS)

    McGovern, Megan; Buttlar, William G.; Reis, Henrique

    2016-04-01

    The efficacy of asphalt rejuvenator on restoring the properties of oxidatively aged asphalt was tested via a non-collinear ultrasonic subsurface wave mixing technique modified for field use. Longitudinal transducers were mounted on angle wedges to generate subsurface dilatational waves to allow for pavement evaluation when there is only access to one side. Because in the field the asphalt concrete (AC) pavement properties (i.e., ultrasonic velocities and attenuations) are unknown, a pre-determined fixed incident angle (based on the AC mixture type) was used, which allows for practical implementation in the field. Oxidative aged AC specimens were coated with rejuvenator (10% by weight of the binder) and left to dwell for varying amounts of time. Once the dwell time reached the desired amount, the specimen was immediately ultrasonically tested. The frequency ratio, f2/f1, at which the interaction took place and the normalized nonlinear wave generation parameter, β/β0, were recorded and compared against a reference plot. It was observed that the rejuvenator had the effect of restoring the nonlinear properties to those corresponding to a virgin sample after a sufficient amount of dwell time. The ability of the rejuvenator to fully penetrate and act on the binder was observed to be dependent on the porosity and aggregate structure, and thus varied for each specimen. As a result, some portions of the binder were restored to a greater extent than others. This non-uniform nature was captured via the nonlinear ultrasonic technique.

  12. Accumulation of free amino acids in marine diatom resting cells during rejuvenation

    NASA Astrophysics Data System (ADS)

    Chen, Changping; Li, Qingyu; Zhou, Qianqian; Sun, Lin; Zheng, Minhua; Gao, Yahui

    2014-01-01

    Many diatoms form resting stages under adverse growth conditions. These resting stages are known to rejuvenate once favorable conditions return, and resume vegetative growth after a certain lag period in which no divisions occurred, but what happens during this period remains unclear. Nitrogen uptake and the accumulation of free amino acids in Skeletonema marinoi resting cells during rejuvenation, but before cell division, were studied in laboratory cultures at different light intensities using the 15N-tracer technique. N uptake rate was higher for the rejuvenating cells at the higher light intensity. We hypothesized that the rapid and increasing N uptake at higher irradiance could enable S. marinoi to rebuild and reorganize its cell contents quickly and so dominate subsequent vegetative growth on the surficial sediment. Compared to the logarithmic growth phase and stationary phase, much higher concentrations of glycine (Gly) and histidine (His) were detected in resting cells, and His appeared to be a storage compound in S. marinoi resting cells. Compared to glutamine, glutamate had the higher 15N label enrichment under the light condition, showing a diel variation of N status during the lag period. The 15N labeled urea was detected at 36 h, compared to the urea cycle intermediates ornithine and citrulline at 30 h, indicating that urea was produced as an N reservoir due to the higher nitrogen uptake in the dark, and that the urea cycle was involved in S. marinoi resting cell rejuvenation.

  13. Rejuvenation of a mountain birch forest by an Epirrita autumnata (Lepidoptera: Geometridae) outbreak

    NASA Astrophysics Data System (ADS)

    Tenow, O.; Bylund, H.; Karlsson, P. S.; Hoogesteger, J.

    2004-03-01

    In 1955, the mountain birch forest in the Abisko valley of northern Sweden was defoliated by caterpillars of the moth Epirrita autumnata with death of stems of the polycormic trees as a result. Since then, some stands have recovered from surviving trees, producing new shoots while other stands became rejuvenated from basal sprouts. Usually, basal sprouting occurs after the death of whole trees or stems. In this case, extensive basal sprouting occurred in spite of only minor stem mortality. Two associated explanations to these differences were explored: (i) the abundant basal sprouting was caused by more top damage (and, hence, a reduced apical dominance) than in stands with less sprouting, (ii) this top damage was caused by a higher caterpillar density in the upper part of trees. Studies made during the outbreak and reported here confirm (i) and reject (ii) by showing that caterpillar densities were lower in the upper part of crowns than in the lower. The more extensive damage in the upper part of crowns may have several explanations. However, a specific sequence of events seemed to produce the rejuvenated stand. The sequence included a severe stress existing before the outbreak (as indicated by a decreased radial stem growth) which was increased by defoliations in two successive years. We, therefore, hypothesize that top dieback was caused by between - and within - stem competition for depleted carbohydrate resources at the expense of tree tops. The contributions of different types of sprouts to the rejuvenation and prerequisites for an outbreak to rejuvenate stands are discussed.

  14. Pedagogic Rejuvenation in Teacher Education in India: Concept in NCFTE 2009

    ERIC Educational Resources Information Center

    Nath, Baiju K.; M.S, Sheeba

    2009-01-01

    The educational scenario in India country is now passing through an era of renovation and refinement. The school education as well as higher education is included in this rejuvenation, with least consideration to teacher education. Pedagogic changes gained momentum by the inception of nation wide schemes such as MLL, DPEP, SSA and the emerging…

  15. The Human Face of Technological Change. Theme Papers from the Silver Jubilee Conference of the Australian College of Education (25th, Australian Capital Territory, Canberra, May 5-9, 1984).

    ERIC Educational Resources Information Center

    Randell, Shirley, Ed.

    Papers presented at the 25th annual conference of the Australia College of Education addressed four major themes: The Brave New World of 1984; The Communications Revolution; Being Human in a Technological Age; and Implications of the Technological Society of Education. Papers in this volume include: (1) "The Challenge of Education in the Brave New…

  16. Mathematics Education in the South Pacific. Proceedings of the Annual Conference of the Mathematics Education Research Group of Australasia Incorporated (25th, Auckland, New Zealand, July 7-10, 2002). Volume I [and] Volume II.

    ERIC Educational Resources Information Center

    Barton, Bill, Ed.; Irwin, Kathryn C., Ed.; Pfannkuch, Maxine, Ed.; Thomas, Michael O. J., Ed.

    This document contains the proceedings of the 25th annual conference of the Mathematics Education Research Group of Australia (MERGA) held at the University of Auckland, New Zealand. The focus of this meeting is mathematics education in the South Pacific. Presentations are centered around the topic of numeracy in primary or elementary school.…

  17. The Quest for Excellence in Teacher Education. International Perspectives on Improving the Quality of Teacher Education. Proceedings of the World Assembly of the International Council on Education for Teaching (25th, Rio de Janeiro, Brazil, July 24-28, 1978).

    ERIC Educational Resources Information Center

    Leavitt, Howard B., Ed.; Klassen, Frank H., Ed.

    This document contains the proceedings of the 25th World Assembly of the International Council on Education for Teaching. The Assembly focused on the topic of improving teacher education on a global scale. Leading educators from every continent participated in workshops, plenary sessions, and group discussions on a variety of topics dealing with…

  18. Post-fire Gully Rejuvenation - Evidence of Process Thresholds Controlled by Vegetation Disturbance

    NASA Astrophysics Data System (ADS)

    Hyde, K.; Woods, S.

    2011-12-01

    High intensity rainfall may trigger gully rejuvenation on hillslopes recently disturbed by wildfire, leading to debris-laden flows which generally contribute the majority of sediment transported in post-fire erosion events. We investigated the extent to which the occurrence of gully rejuvenation can be predicted based upon burn severity, rainfall data and basin morphometric variables. Field surveys were conducted at six Northern Rockies sites to identify occurrence of gully rejuvenation in first order catchments and to map and characterize the location of gully heads. NEXRAD and rain gage data analysis coupled with field observations characterized rainfall intensity and extent. Building on previous work we quantified burn severity using the Vegetation Disturbance Index (VDI), a continuous metric based upon Burned Area Reflectance Classification (BARC) maps derived from satellite imagery using the dNBR algorithm. GIS analysis combined the VDI with morphometric factors expected to influence hillslope stability. Gully heads marked abrupt transition in channel form. Above gully heads, channels were shallow and U-shaped with gentle transition to the hillslope and fine root hairs intact. Angular edges marked deep gully head incisions which down-cut channel floors from 0.2-0.3 to 1.0 meter or more. Any remaining roots were coarse and the hillslope transition was sharp. Gully heads were located at variable distances below the master rill head of the catchment hollow. Distances were obviously greater where live canopy remained upslope. Gully head morphology strongly suggests flow force transition and exceedance of an erosion process threshold. The variable distance of the gully head below the hollow suggest upslope controls influencing initiation point, possibly degree and spatial pattern of burn severity. Binary logistic regression revealed stronger correlation between gully rejuvenation and VDI than morphometric variables. The statistical strength using the continuous

  19. New evidence for rejuvenation of phosphorus retention capacity in EAF steel slag.

    PubMed

    Drizo, Aleksandra; Cummings, John; Weber, David; Twohig, Eamon; Druschel, Greg; Bourke, Bill

    2008-08-15

    The purpose of this research was to investigate phosphorus (P) retention capacity and rejuvenation potential of electric arc furnace (EAF) steel slag from Quebec and New Zealand (NZ) iron melter slag (IMS). Columns filled with slag materials were fed with dairy effluent and subjected to two feeding and one resting cycle(s). P retention capacities and rejuvenation potentials were determined after each feeding cycle. Elemental composition and mineralogical analysis were performed on IMS samples. Finally, chemical fractionation analysis was conducted on both NZ IMS and Quebec EAF steel slags. The results revealed that initiating a resting period in EAF steel slag filters prior to reaching their P saturation point increased the overall filter P retention capacity by 49.5 and 42.4% compared to 28% in a filter which had its resting period initiated after reaching P saturation. The rejuvenation property could play a significant role in full-scale applications by prolonging life expectancy and increasing cost efficiency. P retention and rejuvenation by NZ slag materials was negligible relative to EAF steel slag material from Quebec. Chemical fractionation analysis revealed differences between materials, indicating that the highest quantities of P were bound to Ca and Fe in EAF steel slag and to Ca and Al fractions in iron melter slag. This study also demonstrates that slag's performance is dependent on the source of the material and the steel making practices. Therefore, testing of the P adsorptive capability and, if relevant, the rejuvenation potential of individual steel mill slags, should be a prerequisite prior to their use in field applications. PMID:18767686

  20. [Sanatorium "Arkhangelskoe" celebrates 80th anniversary].

    PubMed

    Kirillov, G N

    2013-10-01

    The article is dedicated to the 80th anniversary of sanatorium "Arkhangelskoe" celebrating in October 2013. Since October 16th, 1933 sanatorium is a military health resort, in 1934 sanatorium was named for "Sanatorium for command personnel of the Red Army". In 1935-1936 such prominent commaders as V.K. Blyukher, A.I. Egorov, A.I. Kork, M.N. Tukhachevskiy, G.M.Shtern, A.V. Khrulev, I.E. Yakir took rest in the sanatorium. Today organization of treatment and diagnostic services in the sanatorium meets modern requirements of medical science. Diagnostics includes the following methods: bicycle ergometry, medical treadmills, ECG and ABP monitoring, rheoencephalography, oscillography, ultrasonic diagnosis, monitoring of lipid and carbonaceous metabolism, blood coagulation and anticoagulation, enzymes, electrolytes and also bacteriologic, immunologic and serological tests. The following treatment methotds are used: climatotherapy, clinical nutrition, exercise therapy, spa treatment, balneo- and fangotherapy. Also methods of magnetotherapy, lasertherapy, ultrasonic therapy, hyperbaric oxygenation, phytotherapy and halotherapy are used. PMID:24611299

  1. 46 CFR 30.10-2a - Anniversary date-TB/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Anniversary date-TB/ALL. 30.10-2a Section 30.10-2a Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-2a Anniversary date—TB/ALL. The term anniversary date means the day and the month of each year,...

  2. 46 CFR 30.10-2a - Anniversary date-TB/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Anniversary date-TB/ALL. 30.10-2a Section 30.10-2a Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-2a Anniversary date—TB/ALL. The term anniversary date means the day and the month of each year,...

  3. Multidisciplinary approach for the study of an Egyptian coffin (late 22nd/early 25th dynasty): combining imaging and spectroscopic techniques.

    PubMed

    Bracci, S; Caruso, O; Galeotti, M; Iannaccone, R; Magrini, D; Picchi, D; Pinna, D; Porcinai, S

    2015-06-15

    This paper demonstrates that an educated methodology based on both non-invasive and micro invasive techniques in a two-step approach is a powerful tool to characterize the materials and stratigraphies of an Egyptian coffin, which was restored several times. This coffin, belonging to a certain Mesiset, is now located at the Museo Civico Archeologico of Bologna (inventory number MCABo EG 1963). Scholars attributed it to the late 22nd/early 25th dynasty by stylistic comparison. The first step of the diagnostic approach applied imaging techniques on the whole surface in order to select measurements spots and to unveil both original and restored areas. Images and close microscopic examination of the polychrome surface allowed selecting representative areas to be investigated in situ by portable spectroscopic techniques: X-ray Fluorescence (XRF), Fiber Optic Reflectance Spectroscopy (FORS) and Fourier Transform Infrared spectroscopy (FTIR). After the analysis of the results coming from the first step, very few selected samples were taken to clarify the stratigraphy of the polychrome layers. The first step, based on the combination of imaging and spectroscopic techniques in a totally non-invasive modality, is quite unique in the literature on Egyptian coffins and enabled us to reveal many differences in the ground layer's composition and to identify a remarkable number of pigments in the original and restored areas. This work offered also a chance to check the limitations of the non-invasive approach applied on a complex case, namely the right localization of different materials in the stratigraphy and the identification of binding media. Indeed, to dissolve any remaining doubts on superimposed layers belonging to different interventions, it was necessary to sample few micro-fragments in some selected areas and analyze them prepared as cross-sections. The original ground layer is made of calcite, while the restored areas show the presence of either a mixture of calcite

  4. Multidisciplinary approach for the study of an Egyptian coffin (late 22nd/early 25th dynasty): Combining imaging and spectroscopic techniques

    NASA Astrophysics Data System (ADS)

    Bracci, S.; Caruso, O.; Galeotti, M.; Iannaccone, R.; Magrini, D.; Picchi, D.; Pinna, D.; Porcinai, S.

    2015-06-01

    This paper demonstrates that an educated methodology based on both non-invasive and micro invasive techniques in a two-step approach is a powerful tool to characterize the materials and stratigraphies of an Egyptian coffin, which was restored several times. This coffin, belonging to a certain Mesiset, is now located at the Museo Civico Archeologico of Bologna (inventory number MCABo EG 1963). Scholars attributed it to the late 22nd/early 25th dynasty by stylistic comparison. The first step of the diagnostic approach applied imaging techniques on the whole surface in order to select measurements spots and to unveil both original and restored areas. Images and close microscopic examination of the polychrome surface allowed selecting representative areas to be investigated in situ by portable spectroscopic techniques: X-ray Fluorescence (XRF), Fiber Optic Reflectance Spectroscopy (FORS) and Fourier Transform Infrared spectroscopy (FTIR). After the analysis of the results coming from the first step, very few selected samples were taken to clarify the stratigraphy of the polychrome layers. The first step, based on the combination of imaging and spectroscopic techniques in a totally non-invasive modality, is quite unique in the literature on Egyptian coffins and enabled us to reveal many differences in the ground layer's composition and to identify a remarkable number of pigments in the original and restored areas. This work offered also a chance to check the limitations of the non-invasive approach applied on a complex case, namely the right localization of different materials in the stratigraphy and the identification of binding media. Indeed, to dissolve any remaining doubts on superimposed layers belonging to different interventions, it was necessary to sample few micro-fragments in some selected areas and analyze them prepared as cross-sections. The original ground layer is made of calcite, while the restored areas show the presence of either a mixture of calcite

  5. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong is the center of attention at the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon. He appeared at the banquet with other former astronauts Edwin 'Buzz' Aldrin, Gene Cernan, Walt Cunningham and others.

  6. Former Apollo astronauts speak at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo astronauts Neil Armstrong (left) and Gene Cernan entertain the audience during an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Edwin 'Buzz' Aldrin and Walt Cunningham. Armstrong was the first man to walk on the moon; Cernan was the last.

  7. Former Apollo astronauts speak at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo astronauts Neil Armstrong (left) and Gene Cernan entertain the audience during an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Edwin 'Buzz' Aldrin and Walt Cunningham. Neil Armstrong was the first man to walk on the moon; Gene Cernan was the last.

  8. Center Director Bridges speaks at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    At an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible, Center Director Roy D. Bridges offers remarks. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were astronauts Neil Armstrong, Edwin 'Buzz' Aldrin, Wally Schirra, Gene Cernan and Walt Cunningham. Neil Armstrong was the first man to walk on the moon; Gene Cernan was the last.

  9. Former Apollo astronauts speak at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo astronauts Edwin 'Buzz' Aldrin (left) and Gene Cernan share stories about their missions for an audience attending an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Gene Cernan and Walt Cunningham. Neil Armstrong was the first man to walk on the moon; Gene Cernan was the last.

  10. The unexpected outcomes of anti-aging, rejuvenation, and life extension studies: an origin of modern therapies.

    PubMed

    Stambler, Ilia

    2014-06-01

    The search for life-extending interventions has been often perceived as a purely academic pursuit, or as an unorthodox medical enterprise, with little or no practical outcome. Yet, in fact, these studies, explicitly aiming to prolong human life, often constituted a formidable, though hardly ever acknowledged, motivation for biomedical research and discovery. At least several modern biomedical fields have originated directly from rejuvenation and life extension research: (1) Hormone replacement therapy was born in Charles-Edouard Brown-Séquard's rejuvenation experiments with animal gland extracts (1889). (2) Probiotic diets originated in Elie Metchnikoff's conception of radically prolonged "orthobiosis" (c. 1900). (3) The development of clinical endocrinology owed much to Eugen Steinach's "endocrine rejuvenation" operations (c. 1910s-1920s). (4) Tissue transplantations in humans (allografts and xenografts) were first widely performed in Serge Voronoff's "rejuvenation by grafting" experiments (c. 1910s-1920s). (5) Tissue engineering was pioneered during Alexis Carrel's work on cell and tissue immortalization (c. 1900-1920). (6) Cell therapy (and particularly human embryonic cell therapy) was first widely conducted by Paul Niehans for the purposes of rejuvenation as early as the 1930s. Thus, the pursuit of life extension and rejuvenation has constituted an inseparable and crucial element in the history of biomedicine. Notably, the common principle of these studies was the proactive maintenance of stable, long-term homeostasis of the entire organism. PMID:24524368

  11. Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients.

    PubMed

    Park, Kui Young; Seok, Joon; Rho, Nark Kyoung; Kim, Beom Joon; Kim, Myeung Nam

    2016-01-01

    Aging well has become the new target of preventative medicine, and aesthetic dermatology can contribute to this request. The polynucleotide (PN) containing products not only fill the space, but improve tissue regeneration, resulting in more natural tissue regeneration. Five Korean women received four times injections of long-chain PN filler in two-week intervals for skin rejuvenation. About 0.05 mL of material was injected in 40 points of one-side cheek. The pore and skin thickness were markedly improved in the patients in their 30s, whereas skin tone, melanin, wrinkles, and sagging were noticeably improved for patients in their 40s. There are no serious side effects. In conclusion, intradermal long-chain PN filler injection seems to be an effective and safe treatment for skin rejuvenation. PMID:26814448

  12. Epidermal and dermal changes in response to various skin rejuvenation methods.

    PubMed

    Helbig, D; Simon, J C; Paasch, U

    2010-12-01

    During the last years, a number of new devices have been developed to improve the dermal and epidermal signs of photo- and chronological skin ageing. There are well-established ablative and non-ablative skin resurfacing options using different lasers and light sources, but side effects have been observed frequently. A recently developed photorejuvenation method using non-thermal stimulation of skin cells with low energy and narrow band light has been termed photomodulation. Light emitting diodes are the ideal source of this kind of light that stimulate mitochondrial cell organelles leading to up-regulation of cytochrome electron transport pathway leading to mitochondrial DNA gene modulation. This paper reviews the most current knowledge of intrinsic and extrinsic changes of ageing and summarizes different systems for skin rejuvenation with focus on non-thermal non-ablative skin rejuvenation modalities. PMID:20572891

  13. Aging hair follicles rejuvenated by transplantation to a young subcutaneous environment.

    PubMed

    Cao, Wenluo; Li, Lingna; Kajiura, Satoshi; Amoh, Yasuyuki; Tan, Yuying; Liu, Fang; Hoffman, Robert M

    2016-04-17

    We demonstrate in the present study that young host mice rejuvenate aged hair follicles after transplantation. Young mice promote the hair shaft growth of transplanted old hair follicles, as well as young follicles, in contrast to old host mice, which did not support hair-shaft growth from transplanted old or young follicles. Nestin-expressing hair follicle-associated pluripotent (HAP) stem cells of transplanted old and young hair follicles remained active in young host nude mice. In contrast, the nestin-expressing HAP stem cells in young and old hair follicles transplanted to old nude mice were not as active as in young nude host mice. The present study shows that transplanted old hair follicles were rejuvenated by young host mice, suggesting that aging may be reversible. PMID:26940664

  14. Rejuvenation of stellar mergers and the origin of magnetic fields in massive stars

    NASA Astrophysics Data System (ADS)

    Schneider, F. R. N.; Podsiadlowski, Ph.; Langer, N.; Castro, N.; Fossati, L.

    2016-04-01

    Approximately 10 per cent of massive OBA main-sequence (MS) and pre-MS stars harbour strong, large-scale magnetic fields. At the same time, there is a dearth of magnetic stars in close binaries. A process generating strong magnetic fields only in some stars must be responsible with the merging of pre-MS and MS stars being suggested as one such channel. Stars emerging from the coalescence of two MS stars are rejuvenated, appearing younger than they are. They can therefore be identified by comparison with reference clocks. Here, we predict the rejuvenation of MS merger products over a wide range of masses and binary configurations calibrated to smoothed-particle-hydrodynamical merger models. We find that the rejuvenation is of the order of the nuclear time-scale and is strongest in the lowest mass mergers and the most evolved binary progenitors with the largest mass ratios. These predictions allow us to put constraints on the binary progenitors of merger products. We show that the magnetic stars HR 2949 and τ Sco are younger than the potential binary companion HR 2948 and the Upper-Sco association, respectively, making them promising merger candidates. We find that the age discrepancies and the potential binary progenitors of both are consistent with them being rejuvenated merger products, implying that their magnetic fields may originate from this channel. Searching for age discrepancies in magnetic stars is therefore a powerful way to explore which fraction of magnetic stars may have obtained their strong magnetic field in MS mergers and to improve our understanding of magnetism in massive stars and their remnants.

  15. Facial rejuvenation for middle-aged women: a combined approach with minimally invasive procedures

    PubMed Central

    Goldman, Alberto; Wollina, Uwe

    2010-01-01

    Facial rejuvenation is a significant process involved in restoring youthfulness. The introduction of less invasive procedures has increased acceptance of such procedures. Often a combination of different techniques allows individualized treatment with optimal outcomes. Furthermore, this leads to a natural look without a significant downtime. We report herein the use of such a combined approach in middle-aged women with particular emphasis on botulinum toxin type A, dermal fillers, and chemical peels. PMID:20924438

  16. Assessment of service induced microstructural damage and its rejuvenation in turbine blades

    NASA Astrophysics Data System (ADS)

    Koul, A. K.; Castillo, R.

    1988-08-01

    Correlations between service induced microstructural degradation and creep properties in investment cast IN738LC turbine blades are discussed. Microstructural degradation in the form of γ’ coarsen-ing, MC carbide degeneration, formation of continuous networks of grain boundary M23C6 carbides, and the disappearance of serrated grain boundaries are considered in some detail. Their influence on primary ( t p ,ɛ p ), secondary ( t s , ɛ s ,ɛ m ) and tertiary (tt, ɛt) creep behavior is analyzed through rela-tionships of the form: left( {{t_p + t_s }/{\\varepsilon _p + \\varepsilon _s }} right)dot \\varepsilon _m = K(Initial transient behavior) begin{gathered} left( {t_{t/\\varepsilon _t }^{2 33} } right)dot \\varepsilon _m = K(Intragranular creep governed \\ by γ ' interparticle spacing) \\ begin{gathered} left[ { - t_{t/(e^{ - 50_\\varepsilon } t - 1)} } right]dot \\varepsilon _m = K_2 (Intragranular creep governed \\ by mobile dislocation density) \\ and left( {t_t /\\varepsilon _t } right)dot \\varepsilon _m = K(Grain boundary cavity nucleation) These relationships are able to reveal service induced degeneration effects and can therefore be used to qualify rejuvenated blades. A systematic strategy for designing a HIPping rejuvenation cycle for Ni-base superalloys is presented. Once a rejuvenation cycle is designed, the above-mentioned relationships can then be used to analyze the extent of the rejuvenation of microstructure and creep properties in reheat-treated or hot isostatically pressed service exposed turbine blades. The influ-ence of trace amounts of Zr on creep properties of service exposed IN738LC turbine blades is also highlighted.

  17. The evolution of wrinkle removal: use of lasers and other devices in facial rejuvenation.

    PubMed

    Tholen, Richard H

    2012-06-01

    Lasers have revolutionized facial rejuvenation. Various wavelengths, more powerful machines allowing shorter shutter times and more precise vaporization, and other innovations led physicians and their patients to embrace ablative laser technology. The results have not always been positive, however. Over-adoption by poorly trained physicians led to highly publicized problems and the development of a whole class of nonablative machines as well as fractional laser technology. This article reviews the evolution of wrinkle removal by lasers and other devices. PMID:22866499

  18. Quantitative evaluation of rejuvenators to restore embrittlement temperatures in oxidized asphalt mixtures using acoustic emission

    NASA Astrophysics Data System (ADS)

    Sun, Zhe; Farace, Nicholas; Arnold, Jacob; Behnia, Behzad; Buttlar, William G.; Reis, Henrique

    2015-03-01

    Towards developing a method capable to assess the efficiency of rejuvenators to restore embrittlement temperatures of oxidized asphalt binders towards their original, i.e., unaged values, three gyratory compacted specimens were manufactured with mixtures oven-aged for 36 hours at 135 °C. In addition, one gyratory compacted specimen manufactured using a short-term oven-aged mixture for two hours at 155 °C was used for control to simulate aging during plant production. Each of these four gyratory compacted specimens was then cut into two cylindrical specimen 5 cm thick for a total of six 36-hour oven-aged specimens and two short term aging specimens. Two specimens aged for 36 hours and the two short-term specimens were then tested using an acoustic emission approach to obtain base acoustic emission response of short-term and severely-aged specimens. The remaining four specimens oven-aged for 36 hours were then treated by spreading their top surface with rejuvenator in the amount of 10% of the binder by weight. These four specimens were then tested using the same acoustic emission approach after two, four, six, and eight weeks of dwell time. It was observed that the embrittlement temperatures of the short-term aged and severely oven-aged specimens were -25 °C and - 15 °C, respectively. It was also observed that after four weeks of dwell time, the rejuvenator-treated samples had recuperated the original embrittlement temperatures. In addition, it was also observed that the rejuvenator kept acting upon the binder after four weeks of dwell time; at eight weeks of dwell time, the specimens had an embrittlement temperature about one grade cooler than the embrittlement temperature corresponding to the short-term aged specimen.

  19. The AAS Visiting Professor Programs: Three Anniversaries

    NASA Astrophysics Data System (ADS)

    Philip, A. G. Davis

    2003-05-01

    . Shapley visits have been made to Canadian institutions since 1976 and to Mexican institutions since 1998. After the summer meeting it will be the start of the 10th year of my directing the program. On May 26 there will be a Shapley Dinner at Dyer Observatory in Nashville for the Shapley lecturers who are attending the AAS meeting and we will celebrate these three anniversaries.

  20. CP-1 70th Anniversary Symposium

    SciTech Connect

    Len Koch; Harold Agnew

    2012-07-11

    Dr. Harold Agnew, retired director of Los Alamos National Laboratory and one of 49 people present on December 2, 1942 when the world’s first man-made controlled nuclear chain reaction was achieved with the CP-1 reactor, and Dr. Len Koch, one of Argonne’s earliest staff members and a designer of EBR-I, the first liquid metal-cooled fast reactor, spoke about their early work during “The Dawn of the Nuclear Age”, a Director’s Special Symposium held as one of the events to commemorate the 70th anniversary year of CP-1 achieving criticality. The symposium was moderated by Dr. Charles Till, a retired Argonne associate laboratory director who led Argonne’s nuclear engineering programs throughout the 1980’s and ‘90’s. Dr. Agnew painted a vivid picture of the challenges and rewards of working in Enrico Fermi’s group under strict security conditions and the complete faith all in the group had in Fermi’s analyses. He stated that no one ever doubted that CP-1 would achieve criticality, and when the moment came, those present acknowledged the accomplishment with little more than a subdued toast of chianti from a bottle provided by reactor physicist Eugene Wigner. This experimental work on nuclear reactors was continued in the Chicago area and led first by Fermi and then Walter Zinn, another member of Fermi’s CP-1 group, resulting in the formal establishment of Argonne National Laboratory on July 1, 1946. Dr. Koch described how much he enjoyed working at Argonne through the 1950’s and ‘60’s and contributing to many of the research “firsts” that Argonne achieved in the nuclear energy field and led to the foundation of the commercial nuclear power generation industry. His reminiscences about all that was achieved with EBR-I and how that work then led into Argonne’s design, building, and operation of EBR-II as a full demonstration of a fast reactor power plant brought Argonne’s nuclear energy legacy to life for everyone in the auditorium. These

  1. Fluoxetine tenth anniversary update: the progress continues.

    PubMed

    Stokes, P E; Holtz, A

    1997-01-01

    This tenth anniversary review/update of fluoxetine concentrates on the past 5 years of its clinical application. The mechanism of action of fluoxetine; its metabolism; its efficacy in patients with various diagnostic subgroups of depression, patients with coincident medical disease, children and adolescents with depression, patients with eating disorders, and patients with obsessive-compulsive disorder (OCD); its long-term (maintenance) efficacy; its side effects and toxicity; and pharmacoeconomic considerations are reviewed. Pharmacotherapy is currently the only proven method for treating major depressive disorder that is applicable to all levels of severity of major depressive illness. Since its introduction 10 years ago, fluoxetine has been available to psychiatrists, primary care physicians, and other nonpsychiatric physicians as full-dose effective pharmacotherapy for patients with depression. Fluoxetine has been widely prescribed by physicians knowledgeable in pharmacology and in the treatment of depression because of its proven efficacy (ie, equal to that of tricyclic antidepressants [TCAs]), its ease of administration (with full therapeutic dosing usually starting from day 1), its generally benign side-effect profile, its remarkable safety in over-dose, and its proven effectiveness in the most common depressed patient population--anxious, agitated, depressed patients--as well as in patients with various subtypes and severities of depression. In more recent years it has also proved effective in the treatment of bulimia, an entity for which only limited or inadequate treatment options had been previously available. In OCD, fluoxetine, with its more acceptable side-effect profile and greater ease of dosing, presents a favorable alternative to previous drug therapy and is useful in treating both obsessions and compulsions. Fluoxetine is currently recognized among clinicians as efficacious in treating anxiety disorders and is being used successfully in special

  2. CP-1 70th Anniversary Symposium

    ScienceCinema

    Len Koch; Harold Agnew

    2013-06-05

    Dr. Harold Agnew, retired director of Los Alamos National Laboratory and one of 49 people present on December 2, 1942 when the world?s first man-made controlled nuclear chain reaction was achieved with the CP-1 reactor, and Dr. Len Koch, one of Argonne?s earliest staff members and a designer of EBR-I, the first liquid metal-cooled fast reactor, spoke about their early work during ?The Dawn of the Nuclear Age?, a Director?s Special Symposium held as one of the events to commemorate the 70th anniversary year of CP-1 achieving criticality. The symposium was moderated by Dr. Charles Till, a retired Argonne associate laboratory director who led Argonne?s nuclear engineering programs throughout the 1980?s and ?90?s. Dr. Agnew painted a vivid picture of the challenges and rewards of working in Enrico Fermi?s group under strict security conditions and the complete faith all in the group had in Fermi?s analyses. He stated that no one ever doubted that CP-1 would achieve criticality, and when the moment came, those present acknowledged the accomplishment with little more than a subdued toast of chianti from a bottle provided by reactor physicist Eugene Wigner. This experimental work on nuclear reactors was continued in the Chicago area and led first by Fermi and then Walter Zinn, another member of Fermi?s CP-1 group, resulting in the formal establishment of Argonne National Laboratory on July 1, 1946. Dr. Koch described how much he enjoyed working at Argonne through the 1950?s and ?60?s and contributing to many of the research ?firsts? that Argonne achieved in the nuclear energy field and led to the foundation of the commercial nuclear power generation industry. His reminiscences about all that was achieved with EBR-I and how that work then led into Argonne?s design, building, and operation of EBR-II as a full demonstration of a fast reactor power plant brought Argonne?s nuclear energy legacy to life for everyone in the auditorium. These engaging presentations prompted a

  3. Spinoff 2002: Fortieth Anniversary Technology Utilization Program

    NASA Technical Reports Server (NTRS)

    2002-01-01

    . Each section of Spinoff 2002 provides compelling evidence of the Technology Transfer Program's success and value. With commercial products and successes spanning from work on the Apollo missions to the International Space Station, the 40th anniversary of the Technology Transfer Program invites us to celebrate our history while planning the future.

  4. Surface rejuvenation for multilayer metal deposition on polymer microspheres via self-seeded electroless plating

    NASA Astrophysics Data System (ADS)

    Karagoz, Bunyamin; Sirkecioglu, Okan; Bicak, Niyazi

    2013-11-01

    A surface rejuvenation process was developed for generation variable thickness of metal deposits on polymer microspheres via electroless plating. Thus, Ni(II), Cu(II) and Ag(I) complexes formed on triethylenetetramine (TETA) functional crosslinked poly(glycidyl methacrylate) (PGMA) microspheres were reduced to zero-valent metals. The resulting metals (1.1-1.5 mmol g-1) were employed as seed points for electroless metal plating (self-seeding) without using Pd or tin pre-activating species. Treatment of the metalized surfaces with hydrazine or hydrazinium formate was demonstrated to reactivate (rejuvenate) the surface and allows further metal deposition from electroless plating solutions. Followed repeating of the surface rejuvenation-metalization steps resulted in step wise increasing of the metal deposits (90-290 mg per g in each cycle), as inferred from metal analyses, ESEM and XPS analysis. Experiments showed that, after 6 times of cycling the metal deposits exceed 1 g per g of the microspheres on average. The process seemed to be promising for tuning up of the metal thickness by stepwise electroless plating.

  5. Development of Facial Rejuvenation Procedures: Thirty Years of Clinical Experience with Face Lifts

    PubMed Central

    Kim, Byung Jun; Choi, Jun Ho

    2015-01-01

    Facial rejuvenation procedures can be roughly divided into face lift surgery and nonoperative, less invasive procedures, such as fat grafts, fillers, botulinum toxin injections, thread lifts, or laserbrasion. Face lift surgery or rhytidectomy is the procedure most directly associated with rejuvenation, due to its fundamental ability to restore the anatomical changes caused by aging. Various methods of face lift surgery have been developed over the last hundred years, thanks to advances in the understanding of facial anatomy and the mechanisms of aging, as well as the dedication of innovative surgeons. However, no generally applicable standard method exists, because the condition of each patient is different, and each operative method has advantages and disadvantages. Specific characteristics of the skin of Asians and their skeletal anatomy should be considered when determining the operative method to be used on Asian patients. Plastic surgeons should improve their ability to analyze the original aesthetic properties and problem areas of each patient, drawing on scientific knowledge about the aging process, and they should develop the skills necessary to perform various rejuvenative techniques. In the present article, we reviewed various face lift procedures and the current methods of modified double plane face lift, based on our clinical experience of over 30 years. PMID:26430622

  6. Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain.

    PubMed

    De Jonge, Natalie; Garcia-Pino, Abel; Buts, Lieven; Haesaerts, Sarah; Charlier, Daniel; Zangger, Klaus; Wyns, Lode; De Greve, Henri; Loris, Remy

    2009-07-31

    Toxin-antitoxin modules are small regulatory circuits that ensure survival of bacterial populations under challenging environmental conditions. The ccd toxin-antitoxin module on the F plasmid codes for the toxin CcdB and its antitoxin CcdA. CcdB poisons gyrase while CcdA actively dissociates CcdB:gyrase complexes in a process called rejuvenation. The CcdA:CcdB ratio modulates autorepression of the ccd operon. The mechanisms behind both rejuvenation and regulation of expression are poorly understood. We show that CcdA binds consecutively to two partially overlapping sites on CcdB, which differ in affinity by six orders of magnitude. The first, picomolar affinity interaction triggers a conformational change in CcdB that initiates the dissociation of CcdB:gyrase complexes by an allosteric segmental binding mechanism. The second, micromolar affinity binding event regulates expression of the ccd operon. Both functions of CcdA, rejuvenation and autoregulation, are mechanistically intertwined and depend crucially on the intrinsically disordered nature of the CcdA C-terminal domain. PMID:19647513

  7. De Novo Assembly of the Transcriptome of Turritopsis, a Jellyfish that Repeatedly Rejuvenates.

    PubMed

    Hasegawa, Yoshinori; Watanabe, Takashi; Takazawa, Masaki; Ohara, Osamu; Kubota, Shin

    2016-08-01

    In most animals, aging is an irreversible process; however the species Turritopsis sp. has been observed to undergo a rejuvenation process as many as 14 times. In the present study, we used multiplexed RNA libraries to obtain the transcriptome from four developmental stages (St) of Turritopsis sp., including (I) immature medusa, (II) dumpling, (III) dumpling with a short stolon, and (IV) polyp, which had recently rejuvenated. A total of 4.02 billion paired-end reads were assembled de novo, yielding 90,327 contigs. Our analyses revealed that significant blast hits were recovered for 74% of the assembled contigs, and 19% were successfully annotated with gene ontology (GO) terms. A BLAST search demonstrated that 32% of the contigs were most similar to Hydra vulgarissequences. Raw reads from each sample were mapped against the contigs to find St-specific genes. This represents the first comprehensive set of de novo transcriptome data for this species, which may provide clues toward a better understanding of cyclical rejuvenation in multicellular animals. PMID:27498796

  8. Theory of Aging, Rejuvenation, and the Nonequilibrium Steady State in Deformed Polymer Glasses

    SciTech Connect

    Chen, Kang

    2010-01-01

    The nonlinear Langevin equation theory of segmental relaxation, elasticity, and mechanical response of polymer glasses is extended to describe the coupled effects of physical aging, mechanical rejuvenation, and thermal history. The key structural variable is the amplitude of density fluctuations, and segmental dynamics proceeds via stress-modified activated barrier hopping on a dynamic free-energy profile. Mechanically generated disorder rejuvenation is quantified by a dissipative work argument and increases the amplitude of density fluctuations, thereby speeding up relaxation beyond that induced by the landscape tilting mechanism. The theory makes testable predictions for the time evolution and nonequilibrium steady state of the alpha relaxation time, density fluctuation amplitude, elastic modulus, and other properties. Model calculations reveal a rich dependence of these quantities on preaging time, applied stress, and temperature that reflects the highly nonlinear competition between physical aging and mechanical disordering. Thermal history is erased in the long-time limit, although the nonequilibrium steady state is not the literal fully rejuvenated freshly quenched glass. The present work provides the conceptual foundation for a quantitative treatment of the nonlinear mechanical response of polymer glasses under a variety of deformation protocols.

  9. Development of Facial Rejuvenation Procedures: Thirty Years of Clinical Experience with Face Lifts.

    PubMed

    Kim, Byung Jun; Choi, Jun Ho; Lee, Yoonho

    2015-09-01

    Facial rejuvenation procedures can be roughly divided into face lift surgery and nonoperative, less invasive procedures, such as fat grafts, fillers, botulinum toxin injections, thread lifts, or laserbrasion. Face lift surgery or rhytidectomy is the procedure most directly associated with rejuvenation, due to its fundamental ability to restore the anatomical changes caused by aging. Various methods of face lift surgery have been developed over the last hundred years, thanks to advances in the understanding of facial anatomy and the mechanisms of aging, as well as the dedication of innovative surgeons. However, no generally applicable standard method exists, because the condition of each patient is different, and each operative method has advantages and disadvantages. Specific characteristics of the skin of Asians and their skeletal anatomy should be considered when determining the operative method to be used on Asian patients. Plastic surgeons should improve their ability to analyze the original aesthetic properties and problem areas of each patient, drawing on scientific knowledge about the aging process, and they should develop the skills necessary to perform various rejuvenative techniques. In the present article, we reviewed various face lift procedures and the current methods of modified double plane face lift, based on our clinical experience of over 30 years. PMID:26430622

  10. European expert recommendations on the use of injectable poly-L-lactic acid for facial rejuvenation.

    PubMed

    Alessio, Redaelli; Rzany, Berthold; Eve, Linda; Grangier, Yann; Herranz, Pedro; Olivier-Masveyraud, Frédérique; Vleggaar, Danny

    2014-09-01

    Over the last few years, there have been a number of important changes in how we appreciate and understand the aging face. Volume loss is now recognized as a major component of facial aging. Treatment options that replace lost volume are increasingly used for recontouring and rejuvenation of the aging face. In this review we present and discuss the European Expert Group recommendations on the ideal use of the unique collagen stimulator, poly-L-lactic acid (PLLA, Sculptra®, Sinclair Pharmaceuticals) for facial rejuvenation lasting up to 25 months. Optimal results are achieved based on a detailed knowledge of facial anatomy, correct treatment procedure, specifically the right dilution, the correct injection technique, as well as appropriate patient aftercare. PLLA is an effective and safe collagen stimulator that treats the whole face. PLLA is simple to use, provides the foundation for facial rejuvenation, is easy to combine with other treatments, and gives long-lasting effects with a high level of patient satisfaction. PMID:25226006