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Sample records for 2p decay mechanism

  1. 2p-2p decay of 8C and isospin-allowed 2p decay of the isobaric-analog state in 8B

    NASA Astrophysics Data System (ADS)

    Charity, R. J.; Elson, J. M.; Manfredi, J.; Shane, R.; Sobotka, L. G.; Chajecki, Z.; Coupland, D.; Iwasaki, H.; Kilburn, M.; Lee, Jenny; Lynch, W. G.; Sanetullaev, A.; Tsang, M. B.; Winkelbauer, J.; Youngs, M.; Marley, S. T.; Shetty, D. V.; Wuosmaa, A. H.; Ghosh, T. K.; Howard, M. E.

    2010-10-01

    C8 is found to decay to four protons and an α particle in two 2p emission steps. The correlations between the protons in the first step (C8 to Be6) exhibit a significant enhancement in the region of the decay phase space where the two protons have small relative energy, a region sometimes called the diproton region. The decay of the isobaric analog of C8 in B8 is also found to decay by 2p emission. This is the first case of isospin-allowed 2p decay between isobaric analog states.

  2. 2p-2p decay of {sup 8}C and isospin-allowed 2p decay of the isobaric-analog state in {sup 8}B

    SciTech Connect

    Charity, R. J.; Elson, J. M.; Manfredi, J.; Shane, R.; Sobotka, L. G.; Chajecki, Z.; Coupland, D.; Iwasaki, H.; Kilburn, M.; Lee, Jenny; Lynch, W. G.; Sanetullaev, A.; Tsang, M. B.; Winkelbauer, J.; Youngs, M.; Marley, S. T.; Shetty, D. V.; Wuosmaa, A. H.; Ghosh, T. K.

    2010-10-15

    {sup 8}C is found to decay to four protons and an {alpha} particle in two 2p emission steps. The correlations between the protons in the first step ({sup 8}C to {sup 6}Be) exhibit a significant enhancement in the region of the decay phase space where the two protons have small relative energy, a region sometimes called the diproton region. The decay of the isobaric analog of {sup 8}C in {sup 8}B is also found to decay by 2p emission. This is the first case of isospin-allowed 2p decay between isobaric analog states.

  3. Auger decay of Ar 2p satellite states studied with a multielectron coincidence method

    NASA Astrophysics Data System (ADS)

    Nakano, M.; Hikosaka, Y.; Lablanquie, P.; Penent, F.; Huttula, S.-M.; Suzuki, I. H.; Soejima, K.; Kouchi, N.; Ito, K.

    2012-04-01

    The Auger decay channels of the Ar 2p satellite states have been investigated using a multielectron coincidence technique, using a magnetic bottle time-of-flight electron spectrometer. For the Ar+(2p-13p-1np) satellite states the 2p hole is filled first, while for the Ar+(2p-13s-14s) satellite states the 3s hole is filled first with leading to Ar2+(2p-13p-1) states, which subsequently undergo an Auger decay leading to the filling of the 2p hole.

  4. Single, double, and triple Auger decay probabilities of C+(1 s 2 s22 p22 D ,2 P ) resonances

    NASA Astrophysics Data System (ADS)

    Zhou, Fuyang; Ma, Yulong; Qu, Yizhi

    2016-06-01

    Single, double, and triple Auger decay rates of C+(1 s 2 s22 p22 D ,2 P ) resonances were calculated in the framework of perturbation theory. The direct double Auger decay probabilities were calculated by using the approximate formulas according to the knockout and shakeoff mechanisms, in which the knockout mechanism was found to be dominant. Then the knockout mechanism was employed to investigate the complex triple Auger decay process, and the calculated rates have good agreement with the available experimental values.

  5. Final-state screening dynamics in resonant Auger decay at the 2p edge of vanadium

    NASA Astrophysics Data System (ADS)

    Ilakovac, V.; Kralj, M.; Pervan, P.; Richter, M. C.; Goldoni, A.; Larciprete, R.; Petaccia, L.; Hricovini, K.

    2005-02-01

    We investigated the resonant Auger process near the V 2p3/2 edge in vanadium metal. Attention is centered on the onset of Auger decays and their behavior below the 2p3/2 resonance. The 2p3/23d3d decay has a crossover from the Raman-Auger to the normal Auger regime at the 2p ionization threshold. Meanwhile, Auger decays with core holes in the final state have normal Auger behavior even below the ionization threshold, the 2p3/23p3p process being visible at 2.2 eV lower photon energy. The different resonant behavior of these Auger decays can be understood within the one-step model as final-state screening effects affecting the photoexcitation.

  6. Gamow-Teller decay studies with 2p-2h configurations

    NASA Astrophysics Data System (ADS)

    Severyukhin, A. P.; Voronov, V. V.; Borzov, I. N.; Arsenyev, N. N.; Van Giai, Nguyen

    2016-06-01

    Starting from a Skyrme interaction with tensor terms, the β-decay rates have been studied within a microscopic model including the 2p-2h configuration effects. As an application we present the evolution of the neutron-rich Ni isotopes near 78Ni that are important for stellar nucleosynthesis.

  7. Laser excitation combined with 2p photoionization and Auger decay of potassium

    SciTech Connect

    Jaenkaelae, K.; Sankari, R.; Huttula, M.; Calo, A.; Heinaesmaeki, S.; Aksela, S.; Aksela, H.; Schulz, J.; Fritzsche, S.; Rander, T.; Svensson, S.

    2006-02-15

    The 2p photoionization and subsequent L{sub 2,3}M{sub 2,3}M{sub 2,3} Auger decay spectra from free 4s{sub 1/2}{yields}4p{sub 1/2} laser-excited potassium atoms are studied both experimentally and theoretically. The shake-up-structure of the 2p photoelectron spectrum of K is resolved. A direct experimental way for resolving the satellite structure due to conjugate shake-up transitions accompanying the hole creation in the L{sub 2,3}M{sub 2,3}M{sub 2,3} Auger spectrum of nonexcited atoms is presented. Theoretical ab initio computations based on the multiconfiguration Dirac-Fock approach were performed to interpret the experimental findings.

  8. Observation of {chi}{sub bJ}(1P,2P) decays to light hadrons

    SciTech Connect

    Asner, D. M.; Edwards, K. W.; Reed, J.; Briere, R. A.; Tatishvili, G.; Vogel, H.; Onyisi, P. U. E.; Rosner, J. L.; Alexander, J. P.; Cassel, D. G.; Duboscq, J. E.; Ehrlich, R.; Fields, L.; Galik, R. S.; Gibbons, L.; Gray, R.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hertz, D.

    2008-11-01

    Analyzing {upsilon}(nS) decays acquired with the CLEO detector operating at the CESR e{sup +}e{sup -} collider, we measure for the first time the product branching fractions B[{upsilon}(nS){yields}{gamma}{chi}{sub bJ}((n-1)P)]B[{chi}{sub bJ}(n-1)P){yields}X{sub i}] for n=2 and 3, where X{sub i} denotes, for each i, one of the 14 exclusive light-hadron final states for which we observe significant signals in both {chi}{sub bJ}(1P) and {chi}{sub bJ}(2P) decays. We also determine upper limits for the electric dipole (E1) transitions {upsilon}(3S){yields}{gamma}{chi}{sub bJ}(1P)

  9. An efficient query mechanism base on P2P networks

    NASA Astrophysics Data System (ADS)

    Wang, Xiaohua; Mu, Aiqin; Zhao, Defang

    2013-07-01

    How to implement the efficient query is the key problem deployed on P2P networks. This paper analyses the shortage of several query algorithm, and presents a new algorithm DDI, which means distributed searching with double indices. It discusses the popularity of documents and the linking status of the networks, and calculates the availability of the nodes in whole network, determines the route of the query process. It compares the items of time using, the quantity of requests and update information by the emulate experiments. Along with the rapid development of computer network technology, peer-to-peer (referred to as P2P) network research has gradually become mature, and it is widely used in different fields, some large P2P computing project has entered the implementation stage. At present, many more popular software systems such as Gnutella, Freenet, Napster are deployed based on P2P technology. How to achieve effective information query has become one of the key problems of P2P research.

  10. The implementation of a novel P2P service redirection mechanism in passive optical network

    NASA Astrophysics Data System (ADS)

    Jiang, Xinting; Chen, Xue; Ma, Dongchao; Wang, Ning

    2010-12-01

    In order to resolve the P2P topology mismatch problem, a novel P2P service redirection scheme has been proposed by us and the scheme is fully described in reference. Furthermore, we have successfully implemented this mechanism in EPON system. Experimental results show that our scheme can effectively reduce core network traffic, and evidently improve clients' downloading rate.

  11. A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.

    PubMed

    Schewe, Marcus; Nematian-Ardestani, Ehsan; Sun, Han; Musinszki, Marianne; Cordeiro, Sönke; Bucci, Giovanna; de Groot, Bert L; Tucker, Stephen J; Rapedius, Markus; Baukrowitz, Thomas

    2016-02-25

    Two-pore domain (K2P) K(+) channels are major regulators of excitability that endow cells with an outwardly rectifying background "leak" conductance. In some K2P channels, strong voltage-dependent activation has been observed, but the mechanism remains unresolved because they lack a canonical voltage-sensing domain. Here, we show voltage-dependent gating is common to most K2P channels and that this voltage sensitivity originates from the movement of three to four ions into the high electric field of an inactive selectivity filter. Overall, this ion-flux gating mechanism generates a one-way "check valve" within the filter because outward movement of K(+) induces filter opening, whereas inward movement promotes inactivation. Furthermore, many physiological stimuli switch off this flux gating mode to convert K2P channels into a leak conductance. These findings provide insight into the functional plasticity of a K(+)-selective filter and also refine our understanding of K2P channels and the mechanisms by which ion channels can sense voltage. PMID:26919430

  12. A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels

    PubMed Central

    Schewe, Marcus; Nematian-Ardestani, Ehsan; Sun, Han; Musinszki, Marianne; Cordeiro, Sönke; Bucci, Giovanna; de Groot, Bert L.; Tucker, Stephen J.; Rapedius, Markus; Baukrowitz, Thomas

    2016-01-01

    Summary Two-pore domain (K2P) K+ channels are major regulators of excitability that endow cells with an outwardly rectifying background “leak” conductance. In some K2P channels, strong voltage-dependent activation has been observed, but the mechanism remains unresolved because they lack a canonical voltage-sensing domain. Here, we show voltage-dependent gating is common to most K2P channels and that this voltage sensitivity originates from the movement of three to four ions into the high electric field of an inactive selectivity filter. Overall, this ion-flux gating mechanism generates a one-way “check valve” within the filter because outward movement of K+ induces filter opening, whereas inward movement promotes inactivation. Furthermore, many physiological stimuli switch off this flux gating mode to convert K2P channels into a leak conductance. These findings provide insight into the functional plasticity of a K+-selective filter and also refine our understanding of K2P channels and the mechanisms by which ion channels can sense voltage. PMID:26919430

  13. Angle-resolved study of Ar 2p{sub 1/2,3/2}{sup -1} ns,d resonant Auger decay

    SciTech Connect

    Farhat, A.; Humphrey, M.; Langer, B.

    1997-04-01

    The Auger decay of core excited states in rare gases has been subject to rather intense investigation over a number of years due to its complex nature. The authors have measured the intensity distributions and angular distributions ({beta} parameters) for the Auger decay spectra following each of the 2p{sub 1/2,3/2} {r_arrow} 4s, 3d, 4d resonant excitations in argon. This report presents their result only for the angular distributions ({beta} parameters) of the 2p{sub 1/2}{sup {minus}1}4s resonance.

  14. Incentive Mechanism for P2P Content Sharing over Heterogenous Access Networks

    NASA Astrophysics Data System (ADS)

    Sato, Kenichiro; Hashimoto, Ryo; Yoshino, Makoto; Shinkuma, Ryoichi; Takahashi, Tatsuro

    In peer-to-peer (P2P) content sharing, users can share their content by contributing their own resources to one another. However, since there is no incentive for contributing contents or resources to others, users may attempt to obtain content without any contribution. To motivate users to contribute their resources to the service, incentive-rewarding mechanisms have been proposed. On the other hand, emerging wireless technologies, such as IEEE 802.11 wireless local area networks, beyond third generation (B3G) cellular networks and mobile WiMAX, provide high-speed Internet access for wireless users. Using these high-speed wireless access, wireless users can use P2P services and share their content with other wireless users and with fixed users. However, this diversification of access networks makes it difficult to appropriately assign rewards to each user according to their contributions. This is because the cost necessary for contribution is different in different access networks. In this paper, we propose a novel incentive-rewarding mechanism called EMOTIVER that can assign rewards to users appropriately. The proposed mechanism uses an external evaluator and interactive learning agents. We also investigate a way of appropriately controlling rewards based on the system service's quality and managing policy.

  15. The pore structure and gating mechanism of K2P channels

    PubMed Central

    Piechotta, Paula L; Rapedius, Markus; Stansfeld, Phillip J; Bollepalli, Murali K; Erhlich, Gunter; Andres-Enguix, Isabelle; Fritzenschaft, Hariolf; Decher, Niels; Sansom, Mark S P; Tucker, Stephen J; Baukrowitz, Thomas

    2011-01-01

    Two-pore domain (K2P) potassium channels are important regulators of cellular electrical excitability. However, the structure of these channels and their gating mechanism, in particular the role of the bundle-crossing gate, are not well understood. Here, we report that quaternary ammonium (QA) ions bind with high-affinity deep within the pore of TREK-1 and have free access to their binding site before channel activation by intracellular pH or pressure. This demonstrates that, unlike most other K+ channels, the bundle-crossing gate in this K2P channel is constitutively open. Furthermore, we used QA ions to probe the pore structure of TREK-1 by systematic scanning mutagenesis and comparison of these results with different possible structural models. This revealed that the TREK-1 pore most closely resembles the open-state structure of KvAP. We also found that mutations close to the selectivity filter and the nature of the permeant ion profoundly influence TREK-1 channel gating. These results demonstrate that the primary activation mechanisms in TREK-1 reside close to, or within the selectivity filter and do not involve gating at the cytoplasmic bundle crossing. PMID:21822218

  16. Decay of ^10C excited states above the 2p + 2α threshold and the contribution from ``democratic'' two-proton emission

    NASA Astrophysics Data System (ADS)

    Mercurio, K. M.; Charity, R. J.; Shane, R.; Sobotka, L. G.; Elson, J.; Famiano, M.; Wuosmaa, A.; Banu, A.; Fu, C.; Trache, L.; Tribble, R. E.

    2008-04-01

    The decay of ^10C excited states to the 2p +2α exit channel has been studied using an E/A = 10.7 MeV ^10C beam inelastically scattered from a ^9Be target. Levels associated with the two-proton decay to the ground state of ^8Be have been observed. These include states at 5.18 and 6.54 MeV which decay by sequential two-proton emission through the long-lived intermediate state of ^9B. In addition, these two states have branches, or there exist other states at almost the same energies, for which there is no long-lived intermediate state between the two proton emissions. For the 6.57 MeV state, the two protons are preferably emitted on the same side of the decaying ^10C fragment. Evidence is found for a state at E^*= 8.4 MeV in ^10C which decays through the 2.35 MeV second excited state of ^9B. A large data set of kinematically complete ^6Be->2p + α events was also collected.

  17. Method of predicting mechanical properties of decayed wood

    DOEpatents

    Kelley, Stephen S.

    2003-07-15

    A method for determining the mechanical properties of decayed wood that has been exposed to wood decay microorganisms, comprising: a) illuminating a surface of decayed wood that has been exposed to wood decay microorganisms with wavelengths from visible and near infrared (VIS-NIR) spectra; b) analyzing the surface of the decayed wood using a spectrometric method, the method generating a first spectral data of wavelengths in VIS-NIR spectra region; and c) using a multivariate analysis to predict mechanical properties of decayed wood by comparing the first spectral data with a calibration model, the calibration model comprising a second spectrometric method of spectral data of wavelengths in VIS-NIR spectra obtained from a reference decay wood, the second spectral data being correlated with a known mechanical property analytical result obtained from the reference decayed wood.

  18. The two-double mechanism of grid GIS resource discovery based on P2P

    NASA Astrophysics Data System (ADS)

    Zhang, Wen; Gao, Jinsong; Meng, Lingkui

    2006-10-01

    This paper researches on how to realize fast spatial resource discovery in distributed, heterogeneous Grid GIS environment. The characteristic of spatial data as multi-resource, huge volume, heterogeneous formats and time relativity decides that resource discovery in Grid environment is a very complex and exigent problem. Combining the central control with distributed management technology, this paper supposes a two-double resource discovery mechanism with both distributed resource catalog and dynamic hash table, which is just fit to the spatial data access characteristics that distributed in wide area but concentrated in local area. This method overcomes the single node bottleneck by setting up the dynamic service sections among middle layer metadata servers, and utilizes the improved DHT technology to route queries in high efficiency. With the new method, people multi-attribute resource discovery could be supported that not limited by the special keyword as P2P does. It is helpful to solve the spatial information discovery problem in complex environment, which could also enhance the extendibility and credibility of system.

  19. Decay processes of the core-excited states 1s2p3 for Be-like systems with Z=8-54

    NASA Astrophysics Data System (ADS)

    Sang, C. C.; Sun, Y.; Hu, F.

    2016-08-01

    On the basis of a fully relativistic multiconfiguration Dirac-Fock method, a systematic study has been carried out for the energies, radiative and non-radiative (Auger) decay processes of the core-excited states 1s2p3 for Be-like ions with Z=8-54. The energies and radiative transition rates are smoothly varying functions of Z. Auger rates do not change significantly with Z as the radiative rates do. Electron correlation effects on the energies and the radiative transition rates are investigated. Good agreement is found between our results and other theoretical data.

  20. Study of structures and dynamical decay mechanisms for multiquark systems

    NASA Astrophysics Data System (ADS)

    Liu, Xuewen; Ke, Hong-Wei; Liu, Xiang; Li, Xue-Qian

    2016-04-01

    The inner structures of the multiquark states are an interesting subject in hadron physics, generally they may be in tetraquark states which are composed of colored constituents, or in molecular states which are composed of two color singlets, or their mixtures. Therefore, the mechanisms which bind the constituents in a unique system and induce the multiquark states to decay would be different in those cases. In this work, using the quantum mechanics we analyze the dynamical mechanisms inducing decays of the tetraquarks where Y (4630 ) stands as an example for the study, we also comment on the molecular states without making numerical computations.

  1. The signature of initial production mechanisms in isotropic turbulence decay

    NASA Astrophysics Data System (ADS)

    Meldi, M.

    2016-03-01

    In the present work the quantification of the time-lasting effects of production mechanisms in homogeneous isotropic turbulence decay is addressed. The analysis is developed through the use of theoretical tools as well as numerical calculations based on the eddy damped quasinormal Markovian (EDQNM) model. In both cases a modified Lin equation is used, which accounts for production mechanisms as proposed by Meldi, Lejemble, and Sagaut ["On the emergence of non-classical decay regimes in multiscale/fractal generated isotropic turbulence," J. Fluid Mech. 756, 816-843 (2014)]. The approaches used show that an exponential decay law can be observed if the intensity of the forcing is strong enough to drive the turbulence dynamics, before a power-law decay is eventually attained. The EDQNM numerical results indicate that the exponential regime can persist for long evolution times, longer than the observation time in grid turbulence experiments. A rigorous investigation of the self-similar behavior of the pressure spectrum has been performed by a comprehensive comparison of EDQNM data with direct numerical simulation (DNS)/experiments in the literature. While DNS and free decay EDQNM simulations suggest the need of a very high Reλ threshold in order to observe a clear -7/3 slope of the pressure inertial range, experimental data and forced EDQNM calculations indicate a significantly lower value. This observation suggests that the time-lasting effects of production mechanisms, which cannot be excluded in experiments, play a role in the lack of general agreement with classical numerical approaches. These results reinforce the urge to evolve the numerical simulation state of the art towards the prediction of realistic physical states.

  2. Mechanism and regulation of the nonsense-mediated decay pathway

    PubMed Central

    Hug, Nele; Longman, Dasa; Cáceres, Javier F.

    2016-01-01

    The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. The central role of NMD in the control of gene expression requires the existence of buffering mechanisms that tightly regulate the magnitude of this pathway. Here, we will focus on the mechanism of NMD with an emphasis on the role of RNA helicases in the transition from NMD complexes that recognize a PTC to those that promote mRNA decay. We will also review recent strategies aimed at uncovering novel trans-acting factors and their functional role in the NMD pathway. Finally, we will describe recent progress in the study of the physiological role of the NMD response. PMID:26773057

  3. Quantization in Classical Mechanics and Diffusion Mechanism of Alpha Decay, Proton and Cluster Radioactivity, Spontaneous Fission

    SciTech Connect

    Rusov, V. D.; Vlasenko, D. S.; Deliyergiyev, M. A.; Mavrodiev, S. Cht.

    2010-01-01

    Based on the Chetaev generalized theorem the Schroedinger equation as the stability condition of trajectories in classical dynamics in the presence of dissipative forces is derived. In the framework of this approach the alternative model for unified description of alpha decay, spontaneous fission, cluster and proton radioactivity and is developed. We show the possibility of the classical (without tunneling) description of radioactive decay of heavy nuclei, when the so called noise-induced transition or, in other words, the stochastic channel of radioactive decay conditioned by the Kramers diffusion mechanism is generated under certain conditions.Using the ENSDF nuclear data, we have found the parametrized solutions of the Kramers equation of the Langevin type by the Alexandrov dynamic auto-regularization method (REGN-Dubna program). These solutions describe with high-accuracy the dependences of half-life (the decay probability) of heavy radioactive nuclei on total kinetic energy of daughter decay products.Verification of the inverse problem solution in the framework of the universal Kramers description of alpha decay, spontaneous fission, cluster and proton radioactivity, which based on the newest experimental data for alpha-decay of even-even superheavy nuclei (Z = 114, 116, 118), shows good coincidence of the experimental and theoretical dependences of half-life on alpha-decay energy.

  4. Quantization in Classical Mechanics and Diffusion Mechanism of Alpha Decay, Cluster Radioactivity, Spontaneous Fission

    SciTech Connect

    Rusov, V. D.; Vlasenko, D. S.; Deliyergiyev, M. A.; Mavrodiev, S. Cht.

    2010-05-04

    Based on the Chetaev generalized theorem the Schredinger equation as the stability condition of trajectories in classical dynamics in the presence of dissipative forces is derived. In the framework of this approach the alternative model for unified description of alpha decay, spontaneous fission, cluster radioactivity and is developed. We show the possibility of the classical (without tunneling) description of radioactive decay of heavy nuclei, when the so called noise-induced transition or, in other words, the stochastic channel of radioactive decay conditioned by the Kramers diffusion mechanism is generated under certain conditions.Using the ENSDF nuclear data, we have found the parametrized solutions of the Kramers equation of the Langevin type by the Alexandrov dynamic auto-regularization method (REGN-Dubna program). These solutions describe with high-accuracy the dependences of half-life (the decay probability) of heavy radioactive nuclei on total kinetic energy of daughter decay products.Verification of the inverse problem solution in the framework of the universal Kramers description of alpha decay, spontaneous fission, cluster radioactivity, which based on the newest experimental data for alpha-decay of even-even superheavy nuclei (Z = 114, 116, 118), shows good coincidence of the experimental and theoretical dependences of half-life on alpha-decay energy.

  5. Mechanisms Controlling Subcellular Localization of the G1 Cyclins Cln2p and Cln3p in Budding Yeast

    PubMed Central

    Miller, Mary E.; Cross, Frederick R.

    2001-01-01

    Different G1 cyclins confer functional specificity to the cyclin-dependent kinase (Cdk) Cdc28p in budding yeast. The Cln3p G1 cyclin is localized primarily to the nucleus, while Cln2p is localized primarily to the cytoplasm. Both binding to Cdc28p and Cdc28p-dependent phosphorylation in the C-terminal region of Cln2p are independently required for efficient nuclear depletion of Cln2p, suggesting that this process may be physiologically regulated. The accumulation of hypophosphorylated Cln2 in the nucleus is an energy-dependent process, but may not involve the RAN GTPase. Phosphorylation of Cln2p is inefficient in small newborn cells obtained by elutriation, and this lowered phosphorylation correlates with reduced Cln2p nuclear depletion in newborn cells. Thus, Cln2p may have a brief period of nuclear residence early in the cell cycle. In contrast, the nuclear localization pattern of Cln3p is not influenced by Cdk activity. Cln3p localization requires a bipartite nuclear localization signal (NLS) located at the C terminus of the protein. This sequence is required for nuclear localization of Cln3p and is sufficient to confer nuclear localization to green fluorescent protein in a RAN-dependent manner. Mislocalized Cln3p, lacking the NLS, is much less active in genetic assays specific for Cln3p, but more active in assays normally specific for Cln2p, consistent with the idea that Cln3p localization explains a significant part of Clnp functional specificity. PMID:11509671

  6. Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast.

    PubMed Central

    He, F; Brown, A H; Jacobson, A

    1996-01-01

    Rapid turnover of nonsense-containing mRNAs in the yeast Saccharomyces cerevisiae is dependent on the products of the UPF1 (Upf1p), NMD2/UPF2 (Nmd2p) and UPF3 (Upf3p) genes. Mutations in each of these genes lead to the selective stabilization of mRNAs containing early nonsense mutations without affecting the decay rates of most other mRNAs. NMD2 was recently identified in a two-hybrid screen as a gene that encodes a Upf1p-interacting protein. To identify the amino acids essential to this interaction, we used two-hybrid analysis as well as missense, nonsense, and deletion mutants of NMD2, and mapped the Upf1p-interacting domain of Nmd2p to a 157-amino acid segment at its C-terminus. Mutations in this domain that disrupt interaction with Upf1p also disrupt nonsense-mediated mRNA decay. A dominant-negative deletion allele of NMD2 identified previously includes the Upf1p-interacting domain. However, mutations in the Upf1p-interacting domain do not affect dominant-negative inhibition of mRNA decay caused by this allele, suggesting interaction with yet another factor. These results, and the observation that deletion of a putative nuclear localization signal and a putative transmembrane domain also inactivate nonsense-mediated mRNA decay, suggest that Nmd2p may contain as many as four important functional domains. PMID:8601282

  7. The "footloose" mechanism: Iceberg decay from hydrostatic stresses

    NASA Astrophysics Data System (ADS)

    Wagner, Till J. W.; Wadhams, Peter; Bates, Richard; Elosegui, Pedro; Stern, Alon; Vella, Dominic; Abrahamsen, E. Povl; Crawford, Anna; Nicholls, Keith W.

    2014-08-01

    We study a mechanism of iceberg breakup that may act together with the recognized melt and wave-induced decay processes. Our proposal is based on observations from a recent field experiment on a large ice island in Baffin Bay, East Canada. We observed that successive collapses of the overburden from above an unsupported wavecut at the iceberg waterline created a submerged foot fringing the berg. The buoyancy stresses induced by such a foot may be sufficient to cause moderate-sized bergs to break off from the main berg. A mathematical model is developed to test the feasibility of this mechanism. The results suggest that once the foot reaches a critical length, the induced stresses are sufficient to cause calving. The theoretically predicted maximum stable foot length compares well to the data collected in situ. Further, the model provides analytical expressions for the previously observed "rampart-moat" iceberg surface profiles.

  8. Comment on ''Effect of entanglement on the decay dynamics of a pair of H(2p) atoms due to spontaneous emission''

    SciTech Connect

    Sancho, Pedro; Plaja, Luis

    2011-06-15

    T. Tanabe et al. [Phys. Rev. A 82, 040101(R) (2010)] have experimentally demonstrated that the emission properties of unstable atoms in entangled and product states are different. The authors define an apparent decay time as a fitting parameter which falls below the lifetime of the single atom for entangled pairs. We argue that their results about coincidence time spectra are correct, but those concerning lifetimes cannot be considered conclusive because they assume the emission of photons by the two atoms to be independent processes, a doubtful hypothesis for entangled states. We suggest an improved evaluation of the lifetimes based on a rigorous approach, which demands some modifications of the experimental procedure.

  9. Comment on ``Effect of entanglement on the decay dynamics of a pair of H(2p) atoms due to spontaneous emission''

    NASA Astrophysics Data System (ADS)

    Sancho, Pedro; Plaja, Luis

    2011-06-01

    T. Tanabe [Phys. Rev. APLRAAN1050-294710.1103/PhysRevA.82.040101 82, 040101(R) (2010)] have experimentally demonstrated that the emission properties of unstable atoms in entangled and product states are different. The authors define an apparent decay time as a fitting parameter which falls below the lifetime of the single atom for entangled pairs. We argue that their results about coincidence time spectra are correct, but those concerning lifetimes cannot be considered conclusive because they assume the emission of photons by the two atoms to be independent processes, a doubtful hypothesis for entangled states. We suggest an improved evaluation of the lifetimes based on a rigorous approach, which demands some modifications of the experimental procedure.

  10. Mechanisms of charge transport in anisotype n-TiO{sub 2}/p-CdTe heterojunctions

    SciTech Connect

    Brus, V. V.; Ilashchuk, M. I.; Kovalyuk, Z. D.; Maryanchuk, P. D.; Ulyanytsky, K. S.; Gritsyuk, B. N.

    2011-08-15

    Surface-barrier anisotype n-TiO{sub 2}/p-CdTe heterojunctions are fabricated by depositing thin titanium-dioxide films on a freshly cleaved surface of single-crystalline cadmium-telluride wafers by reactive magnetron sputtering. It is established that the electric current through the heterojunctions under investigation is formed by generation-recombination processes in the space-charge region via a deep energy level and tunneling through the potential barrier. The depth and nature of the impurity centers involved in the charge transport are determined.

  11. The 'footloose' mechanism: Iceberg decay from hydrostatic stresses

    NASA Astrophysics Data System (ADS)

    Wagner, T. J. W.; Wadhams, P.; Bates, C. R.; Elosegui, P.; Stern, A. A.; Vella, D.; Abrahamsen, E. P.; Crawford, A. J.; Nicholls, K. W.

    2014-12-01

    We study a mechanism of iceberg breakup that may act together with the recognized melt and wave-induced decay processes. Our proposal is based on observations from a recent field experiment on a large ice island in Baffin Bay, East Canada. We observed that successive collapses of the overburden from above an unsupported wavecut at the iceberg waterline created a submerged foot fringing the berg. The buoyancy stresses induced by such a foot may be sufficient to cause moderate-sized bergs to break off from the main berg. A mathematical model is developed to test the feasibility of this mechanism. The results suggest that once the foot reaches a critical length, the induced stresses are sufficient to cause calving. The theoretically predicted maximum stable foot length compares well to the data collected in situ. Further, the model provides analytical expressions for the previously observed 'rampart-moat' iceberg surface profiles. Finally, we comment on the implications for the calving of icebergs from shelf fronts, where similar underwater 'feet' have been observed.

  12. Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms

    PubMed Central

    Bittner, Stefan; Bobak, Nicole; Hofmann, Majella-Sophie; Schuhmann, Michael K.; Ruck, Tobias; Göbel, Kerstin; Brück, Wolfgang; Wiendl, Heinz; Meuth, Sven G.

    2015-01-01

    Lymphocytes express potassium channels that regulate physiological cell functions, such as activation, proliferation and migration. Expression levels of K2P5.1 (TASK2; KCNK5) channels belonging to the family of two-pore domain potassium channels have previously been correlated to the activity of autoreactive T lymphocytes in patients with multiple sclerosis and rheumatoid arthritis. In humans, K2P5.1 channels are upregulated upon T cell stimulation and influence T cell effector functions. However, a further clinical translation of targeting K2P5.1 is currently hampered by a lack of highly selective inhibitors, making it necessary to evaluate the impact of KCNK5 in established preclinical animal disease models. We here demonstrate that K2P5.1 knockout (K2P5.1−/−) mice display no significant alterations concerning T cell cytokine production, proliferation rates, surface marker molecules or signaling pathways. In an experimental model of autoimmune neuroinflammation, K2P5.1−/− mice show a comparable disease course to wild-type animals and no major changes in the peripheral immune system or CNS compartment. A compensatory upregulation of the potassium channels K2P3.1 and KV1.3 seems to counterbalance the deletion of K2P5.1. As an alternative model mimicking autoimmune neuroinflammation, experimental autoimmune encephalomyelitis in the common marmoset has been proposed, especially for testing the efficacy of new potential drugs. Initial experiments show that K2P5.1 is functionally expressed on marmoset T lymphocytes, opening up the possibility for assessing future K2P5.1-targeting drugs. PMID:26213925

  13. Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms.

    PubMed

    Bittner, Stefan; Bobak, Nicole; Hofmann, Majella-Sophie; Schuhmann, Michael K; Ruck, Tobias; Göbel, Kerstin; Brück, Wolfgang; Wiendl, Heinz; Meuth, Sven G

    2015-01-01

    Lymphocytes express potassium channels that regulate physiological cell functions, such as activation, proliferation and migration. Expression levels of K2P5.1 (TASK2; KCNK5) channels belonging to the family of two-pore domain potassium channels have previously been correlated to the activity of autoreactive T lymphocytes in patients with multiple sclerosis and rheumatoid arthritis. In humans, K2P5.1 channels are upregulated upon T cell stimulation and influence T cell effector functions. However, a further clinical translation of targeting K2P5.1 is currently hampered by a lack of highly selective inhibitors, making it necessary to evaluate the impact of KCNK5 in established preclinical animal disease models. We here demonstrate that K2P5.1 knockout (K2P5.1-/-) mice display no significant alterations concerning T cell cytokine production, proliferation rates, surface marker molecules or signaling pathways. In an experimental model of autoimmune neuroinflammation, K2P5.1-/- mice show a comparable disease course to wild-type animals and no major changes in the peripheral immune system or CNS compartment. A compensatory upregulation of the potassium channels K2P3.1 and KV1.3 seems to counterbalance the deletion of K2P5.1. As an alternative model mimicking autoimmune neuroinflammation, experimental autoimmune encephalomyelitis in the common marmoset has been proposed, especially for testing the efficacy of new potential drugs. Initial experiments show that K2P5.1 is functionally expressed on marmoset T lymphocytes, opening up the possibility for assessing future K2P5.1-targeting drugs. PMID:26213925

  14. T(T,2n)4He and 3He(3He,2p)4He: The Reaction Mechanism from Solar Energies to 10 MeV

    NASA Astrophysics Data System (ADS)

    Bacher, A. D.; Brune, C. R.; Sayre, D. B.; Hale, G. M.; Frenje, J. A.; Gatu Johnson, M.

    2016-03-01

    We have studied the energy dependence of the reaction mechanism of the T(t,2n)4He reaction at stellar energies and of its charge symmetric analog reaction 3He(3He,2p)4He at energies up 10 MeV. We find that the reaction mechanism changes dramatically over this energy range in part due to the interference of the two identical fermions in the three-body final state. This contribution is dedicated to the memory of Tom Tombrello, my Ph.D. advisor at Cal Tech, who died in 2014.

  15. Structural stability, electronic, mechanical and thermodynamical properties of CaNi2P2 and CaNi2Sb2 compounds by band structure calculation

    NASA Astrophysics Data System (ADS)

    Harish, R. Sugan; Jayalakshmi, D. S.; Viswanathan, E.; Sundareswari, M.

    2016-05-01

    The mechanical, electronic, thermodynamic properties and structural stability of tetragonal structured CaNi2P2 and CaNi2Sb2 intermetallic compounds has been studied using the FP-LAPW method based on density functional theory. The PBE-GGA exchange correlation has been applied. Using the computed elastic constants, various elastic moduli such as bulk, shear, Young’s modulus, Poisson’s ratio and anisotropy constant are calculated and discussed. Stability of the compounds is confirmed by using their elastic constants. Pugh’s ratio is calculated to analyze the mechanical nature of the compound.

  16. Configuration-interaction-induced dynamic spin polarization of the Ar*(2p{sub 1/2,3/2}{sup -1}4s{sub 1/2}){sub J=1} resonant Auger decay

    SciTech Connect

    Lohmann, B.; Langer, B.; Snell, G.; Canton, S.; Berrah, N.; Kleiman, U.; Becker, U.; Martins, M.

    2005-02-01

    Spin-resolved measurements of the Ar{sup *}(2p{sub 1/2,3/2}{sup -1}4s{sub 1/2}){sub J=1} resonantly excited L{sub 2,3}M{sub 2,3}M{sub 2,3} Auger decay have been performed. The low resolution Auger spectrum, which due to cancellation between different multiplet components should exhibit virtually zero dynamic spin polarization, reveals an unexpected nonvanishing polarization effect. Calculations within a relativistic distorted wave approximation explain this effect as configuration-interaction (CI) induced. The CI generates experimentally unresolved fine structure components with low and high total angular momentum, giving rise to asymmetric cases where the high J part of certain multiplets is suppressed by internal selection rules for diagram lines. In this case, only the low J components survive with no partner for spin-polarization cancellation.

  17. MEASUREMENT OF THE RADIATIVE DECAY RATE OF THE METASTABLE (2s {sup 2}2p {sup 5}{sub 3/2}3s{sub 1/2}){sub (J=2)} LEVEL IN Fe XVII

    SciTech Connect

    Crespo Lopez-Urrutia, J. R.; Beiersdorfer, P.

    2010-09-20

    The radiative decay rate of the (2s {sup 2}2p {sup 5}{sub 3/2}3s{sub 1/2}){sub J=2} {yields} (2s {sup 2}2p {sup 6}){sub J=0} transition was measured in Ne-like Fe XVII. This transition forms the prominent magnetic quadrupole line, dubbed M2 or 3H, in the Fe XVII spectrum at 17.10 A. Different theoretical models predict radiative rates for this transition that diverge by almost a factor of 2, making intensity predictions for this line uncertain in environments where it is affected by de-excitation due to either electron-impact collisions or photoionization. Our result of (2.04{sup +0.03}{sub -0.09}) x 10{sup 5} s{sup -1} is very close to the value of 2.06 x 10{sup 5} s{sup -1} predicted by the Flexible Atomic Code.

  18. Shell model nuclear matrix elements for competing mechanisms contributing to double beta decay

    SciTech Connect

    Horoi, Mihai

    2013-12-30

    Recent progress in the shell model approach to the nuclear matrix elements for the double beta decay process are presented. This includes nuclear matrix elements for competing mechanisms to neutrionless double beta decay, a comparison between closure and non-closure approximation for {sup 48}Ca, and an updated shell model analysis of nuclear matrix elements for the double beta decay of {sup 136}Xe.

  19. Selective decay hypothesis at high mechanical and magnetic Reynolds numbers

    NASA Astrophysics Data System (ADS)

    Matthaeus, W. H.; Montgomery, D.

    1980-12-01

    Implications of certain applications of turbulence theory to two-dimensional turbulence and magnetohydrodynamic flow are discussed. It is shown that the use of the Navier-Stokes equation (NSE) for measurements of turbulent fluctuations has been effective only for three-dimensional flows. For two-dimensional flows, used for the study of large-scale motions in the atmosphere or ocean, enstrophy is cascaded to high wave numbers and dissipated at a finite rate even at infinite Re. MHD flows are numerically calculated for the two-dimensional case and analytically for the three-dimensional case, for which discrepancies in the relative rates of energy and cross helicity decay lead to a recommendation that numerical calculations for the three-dimensional case be carried out to determine the precise decayed states.

  20. Vortex stretching as a mechanism for quantum kinetic energy decay.

    PubMed

    Kerr, Robert M

    2011-06-01

    A pair of perturbed antiparallel quantum vortices, simulated using the three-dimensional Gross-Pitaevskii equations, is shown to be unstable to vortex stretching. This results in kinetic energy K(∇ψ) being converted into interaction energy E(I) and eventually local kinetic energy depletion that is similar to energy decay in a classical fluid, even though the governing equations are Hamiltonian and energy conserving. The intermediate stages include the generation of vortex waves, their deepening, multiple reconnections, the emission of vortex rings and phonons, and the creation of an approximately -5/3 kinetic energy spectrum at high wave numbers. All of the wave generation and reconnection steps follow from interactions between the two original vortices. A four vortex example is given to demonstrate that some of these steps might be general. PMID:21702604

  1. Resonance and decay phenomena lead to quantum mechanical time asymmetry

    NASA Astrophysics Data System (ADS)

    Bohm, A.; Bui, H. V.

    2013-04-01

    The states (Schrödinger picture) and observables (Heisenberg picture) in the standard quantum theory evolve symmetrically in time, given by the unitary group with time extending over -∞ < t < +∞. This time evolution is a mathematical consequence of the Hilbert space boundary condition for the dynamical differential equations. However, this unitary group evolution violates causality. Moreover, it does not solve an old puzzle of Wigner: How does one describe excited states of atoms which decay exponentially, and how is their lifetime τ related to the Lorentzian width Γ? These question can be answered if one replaces the Hilbert space boundary condition by new, Hardy space boundary conditions. These Hardy space boundary conditions allow for a distinction between states (prepared by a preparation apparatus) and observables (detected by a registration apparatus). The new Hardy space quantum theory is time asymmetric, i.e, the time evolution is given by the semigroup with t0 <= t < +∞, which predicts a finite "beginning of time" t0, where t0 is the ensemble of time at which each individual system has been prepared. The Hardy space axiom also leads to the new prediction: the width Γ and the lifetime τ are exactly related by τ = hslash/Γ.

  2. The Mechanism of Inactivation of T4 Bacteriophage by Tritium Decay

    PubMed Central

    Funk, Fred; Person, Stanley; Bockrath, Richard C.

    1968-01-01

    Coliphage T4 was used as a model system to study the mechanism of biological inactivation produced by tritium decay. Experimentally, tritiated precursors were incorporated into phage DNA (thymidine-3H) or into phage protein (3H-amino acids). The ratio of killing efficiencies for decays originating in phage DNA to those originating in phage protein was 2.6. Inactivation by decays from labeled amino acids was assumed to occur exclusively from β-particle irradiation of phage DNA. If decays originating in DNA are due solely to irradiation of DNA, then the killing efficiencies reflect the energy transfer paths in phage DNA for decays originating in phage DNA and in the protein coat. The energy transfer paths were determined for the two cases with the help of a computer and found to be very nearly equal to the experimentally determined ratio (2.6). The killing efficiencies for decays originating in phage DNA were 0.12 and for decays originating in protein 0.046. PMID:5678320

  3. Induction of intranuclear membranes by overproduction of Opi1p and Scs2p, regulators for yeast phospholipid biosynthesis, suggests a mechanism for Opi1p nuclear translocation.

    PubMed

    Masuda, Miki; Oshima, Ayaka; Noguchi, Tetsuko; Kagiwada, Satoshi

    2016-03-01

    In the yeast Saccharomyces cerevisiae, the expression of phospholipid biosynthetic genes is suppressed by the Opi1p negative regulator. Opi1p enters into the nucleoplasm from the nuclear membrane to suppress the gene expression under repressing conditions. The binding of Opi1p to the nuclear membrane requires an integral membrane protein, Scs2p and phosphatidic acid (PA). Although it is demonstrated that the association of Opi1p with membranes is affected by PA levels, how Opi1p dissociates from Scs2p is unknown. Here, we found that fluorescently labelled Opi1p accumulated on a perinuclear region in an Scs2p-dependent manner. Electron microscopic analyses indicated that the perinuclear region consists of intranuclear membranes, which may be formed by the invagination of the nuclear membrane due to the accumulation of Opi1p and Scs2p in a restricted area. As expected, localization of Opi1p and Scs2p in the intranuclear membranes was detected by immunoelectron microscopy. Biochemical analysis showed that Opi1p recovered in the membrane fraction was detergent insoluble while Scs2p was soluble, implying that Opi1p behaves differently from Scs2p in the fraction. We hypothesize that Opi1p dissociates from Scs2p after targeting to the nuclear membrane, making it possible to be released from the membrane quickly when PA levels decrease. PMID:26590299

  4. Influence of fluoride additions on biological and mechanical properties of Na2O-CaO-SiO2-P2O5 glass-ceramics.

    PubMed

    Li, H C; Wang, D G; Hu, J H; Chen, C Z

    2014-02-01

    Two series of Na2O-CaO-SiO2-P2O5 glass-ceramics doped with NH4HF2 (G-NH4HF2) or CaF2 (G-CaF2) have been prepared by sol-gel method. The glass-ceramic phase composition and morphology were characterized by X-ray diffraction (XRD) and scanning electron microscopy coupled with energy dispersive spectroscopy (SEM-EDS). The mechanical properties and thermal expansion coefficient were measured by a microhardness tester, an electronic tensile machine and a thermal expansion coefficient tester. The structure difference between these two glass-ceramics was investigated by Fourier transform infrared spectroscopy (FTIR), and the in vitro bioactivity of the glass-ceramics was determined by in vitro simulated body fluid (SBF) immersion test. The hemolysis test, in vitro cytotoxicity test, systemic toxicity test and the implanted experiment in animals were used to evaluate the biocompatibility of the glass-ceramics. The mechanical properties of sample G-NH4HF2 are lower than that of sample G-CaF2, and the bioactivity of sample G-NH4HF2 is better than that of sample G-CaF2. The thermal expansion coefficients of these two glass-ceramics are all closer to that of Ti6Al4V. After 7 days of SBF immersion, apatites were induced on glass-ceramic surface, indicating that the glass-ceramics have bioactivity. The hemolysis test, in vitro cytotoxicity test and systemic toxicity test demonstrate that the glass-ceramics do not cause hemolysis reaction, and have no toxicity to cell and living animal. The implanted experiment in animals shows that bone tissue can form a good osseointegration with the implant after implantation for two months, indicating that the glass-ceramics are safe to serve as implants. PMID:24411365

  5. Disentangling effects of mechanisms that could contribute to the neutrinoless double beta decay

    NASA Astrophysics Data System (ADS)

    Horoi, Mihai; Neacsu, Andrei

    2015-10-01

    Neutrinoless double-beta decay, if observed, would signal physics beyond the Standard Model that could be discovered at energies significantly lower than those at which the relevant degrees of freedom could be excited. Therefore, it could be challenging to further use the neutrinoless double-beta decay observations to distinguish between many beyond Standard Model competing mechanisms to this process. Accurate nuclear structure calculation of the nuclear matrix elements necessary to analyze the decay rates could be helpful to narrow down the list of competing mechanisms, and to better identify the more exotic properties of the neutrinos. We will present information that one can get from the angular and energy distribution of the emitted electron assuming that the right-handed currents exist. Support from U.S. NSF Grant PHY-1404442 and DOE Grant DE-SC0008529 is acknowledged.

  6. Analysis of mechanisms that could contribute to neutrinoless double-beta decay

    NASA Astrophysics Data System (ADS)

    Horoi, Mihai; Neacsu, Andrei

    2016-06-01

    Neutrinoless double-beta decay is a beyond the Standard Model process that would indicate that neutrinos are Majorana fermions, and the lepton number is not conserved. It could be interesting to use the neutrinoless double-beta decay observations to distinguish between several beyond Standard Model mechanisms that could contribute to this process. Accurate nuclear structure calculations of the nuclear matrix elements necessary to analyze the decay rates could be helpful to narrow down the list of contributing mechanisms. We investigate the information one can get from the angular and energy distribution of the emitted electrons and from the half-lives of several isotopes, assuming that the right-handed currents exist. For the analysis of these distributions, we calculate the necessary nuclear matrix elements using shell model techniques, and we explicitly consider interference terms.

  7. Chlorophyll-quinone photochemistry in liposomes: mechanisms of radical formation and decay

    SciTech Connect

    Hurley, J.K.; Tollin, G.

    1980-01-01

    Laser flash photolysis has been used to investigate the mechanism of formation and decay of the radical species generated by light induced electron transfer from chlorophyll a triplet to quinone in egg phosphatidyl choline bilayer vesicles. Chlorophyll triplet quenching by quinone is controlled by diffusion occurring within the bilayer membrane and reflects bilayer viscosity. Radical formation via separation of the intermediate ion pair is also inhibited by increased bilayer viscosity. Cooperativity is observed in this process due to an enhancement of radical separation by electron transfer from semiquinone anion radical to a neighboring quinone molecule. Two modes of radical decay are observed, a rapid recombination occurring within the bilayer and a much slower recombination occurring across the bilayer. The slow decay is only observed with quinones which are not tightly anchored into the bilayer, and is probably the result of electron transfer from semiquinone anion radical formed within the bilayer to a quinone molecule residing at the bilayer-water interface. With benzoquinone, approximately 60% of the radical decay occurs via the slow mode. Triplet to radical conversion efficiencies in the bilayer systems are comparable to those obtained in fluid solution (approx. 60%). However, radical recombination, at least for the slow decay mechanism, is considerably retarded.

  8. 2p radioactivity studied by tracking technique

    SciTech Connect

    Mukha, Ivan

    2010-06-01

    The recent advance in experimental studies of short-lived exotic nuclei beyond the proton drip line is presented. In particular, in-flight decays of proton-unbound nuclei with picosecond lifetimes can be probed by a novel technique which tracks all decay products precisely, and the decay vertices as well as the angular correlations of the fragments are deduced from the measured trajectories. The corresponding pioneering experiment which identified a previously-unknown isotope {sup 19}Mg and its two-proton (2p) radioactivity as well as studied the reference 2p decay of the known isotope {sup 16}Ne is described. Systematic studies of other 2p precursors beyond the proton drip line are foreseen with this powerful technique whose sensitivity is larger by factor of 30 in comparison with a conventional invariant-mass method. The 2p radioactivity candidates {sup 30}Ar, {sup 34}Ca and {sup 26}S are discussed. Information about the respective one-proton unbound nuclei can be obtained with this technique by evaluating proton-heavy-fragment correlations. Systematic studies of nuclei beyond the proton drip line, e.g., the well-known proton resonances above the 'waiting points' in the astrophysical rp-process, {sup 69}Br and {sup 73}Br are feasible.

  9. Leveraging the Mechanism of Oxidative Decay for Adenylate Kinase to Design Structural and Functional Resistances

    PubMed Central

    Howell, Stanley C.; Richards, David H.; Mitch, William A.; Wilson, Corey J.

    2016-01-01

    Characterization of the mechanisms underlying hypohalous acid (i.e., hypochlorous acid or hypobromous acid) degradation of proteins is important for understanding how the immune system deactivates pathogens during infections, and damages human tissues during inflammatory diseases. Proteins are particularly important hypohalous acid reaction targets in pathogens and in host tissues, as evidenced by the detection of chlorinated and brominated oxidizable residues. While a significant amount of work has been conducted for reactions of hypohalous acids with a range of individual amino acids and small peptides, the assessment of oxidative decay in full-length proteins has lagged in comparison. The most rigorous test of our understanding of oxidative decay of proteins is the rational redesign of proteins with conferred resistances to the decay of structure and function. Toward this end, in this study we experimentally determined a putative mechanism of oxidative decay using adenylate kinase as the model system. In turn, we leveraged this mechanism to rationally design new proteins and experimentally test each system for oxidative resistance to loss of structure and function. From our extensive assessment of secondary-structure, protein hydrodynamics and enzyme activity upon hypochlorous acid or hypobromous acid challenge, we have identified two key strategies for conferring structural and functional resistance. Namely, the design of proteins (adenylate kinase enzymes) that are resistant to oxidation requires complementary consideration of protein stability and the modification (elimination) of certain oxidizable residues proximal to catalytic sites. PMID:26266833

  10. Leveraging the Mechanism of Oxidative Decay for Adenylate Kinase to Design Structural and Functional Resistances.

    PubMed

    Howell, Stanley C; Richards, David H; Mitch, William A; Wilson, Corey J

    2015-10-16

    Characterization of the mechanisms underlying hypohalous acid (i.e., hypochlorous acid or hypobromous acid) degradation of proteins is important for understanding how the immune system deactivates pathogens during infections and damages human tissues during inflammatory diseases. Proteins are particularly important hypohalous acid reaction targets in pathogens and in host tissues, as evidenced by the detection of chlorinated and brominated oxidizable residues. While a significant amount of work has been conducted for reactions of hypohalous acids with a range of individual amino acids and small peptides, the assessment of oxidative decay in full-length proteins has lagged in comparison. The most rigorous test of our understanding of oxidative decay of proteins is the rational redesign of proteins with conferred resistances to the decay of structure and function. Toward this end, in this study, we experimentally determined a putative mechanism of oxidative decay using adenylate kinase as the model system. In turn, we leveraged this mechanism to rationally design new proteins and experimentally test each system for oxidative resistance to loss of structure and function. From our extensive assessment of secondary structure, protein hydrodynamics, and enzyme activity upon hypochlorous acid or hypobromous acid challenge, we have identified two key strategies for conferring structural and functional resistance, namely, the design of proteins (adenylate kinase enzymes) that are resistant to oxidation requires complementary consideration of protein stability and the modification (elimination) of certain oxidizable residues proximal to catalytic sites. PMID:26266833

  11. Disentangling the various Mechanisms of neutrinoless double beta decay to extract the neutrino mass

    SciTech Connect

    Vergados, J. D.

    2011-12-16

    It is well known that there exist many mechanisms that may contribute to neutrinoless double beta decay. By exploiting the fact that the associated nuclear matrix elements are target dependent we show that, given definite experimental results on a sufficient number of targets, one can determine or sufficiently constrain all lepton violating parameters including the mass term. As a specific example we show that, given the observation of the 0{nu}{beta}{beta}-decay in three different nuclei, e.g. {sup 76}Ge, {sup 100}Mo and {sup 130}Te, and assuming just three active lepton number violating parameters, e.g. light and heavy neutrino mass mechanisms in left handed currents as well as R-parity breaking SUSY mechanism, one may determine all lepton violating parameters, provided that they are relatively real.

  12. Barr-Freire-Zee mechanism for the hydrogen-ionizing decaying neutrino dark matter

    NASA Astrophysics Data System (ADS)

    Tommasini, Daniele

    1992-12-01

    We consider the scenario of the hydrogen-ionizing decaying neutrino dark matter, advocated by Sciama to solve several ionization problems in astrophysics and cosmology. We show that dangerously large neutrino oscillations are expected in general in the particle physics models introduced to provide the required neutrino masses and dark matter decay lifetime. However, the implementation of a mechanism recently discovered by Barr, Freire and Zee, allows to realize this scenario free of large neutrino oscillations. Furthermore, in this case a mass scale for the light neutrinos, which can be naturally the MSW solar neutrino scale ~ 10-3 eV, is automatically associated to the value ~ 1023 s of the dark matter decay lifetime, needed to solve the ionization problems. A realization of the mechanism in the supersymmetric standard model with broken R-parity is then considered as an example. In that case, the heavy neutrino providing the dark matter is made up mainly by the standard muon neutrino νμ.

  13. The rapid decay phase of the afterglow as the signature of the Blandford-Znajek mechanism

    NASA Astrophysics Data System (ADS)

    Nathanail, A.; Strantzalis, A.; Contopoulos, I.

    2016-02-01

    Gamma-ray bursts (GRBs) are believed to be powered by the electromagnetic extraction of spin energy from a black hole endowed with a magnetic field supported by electric currents in a surrounding disc (Blandford & Znajek). A generic feature of this mechanism is that, under certain fairly general assumptions, the energy loss rate decays exponentially. In this work, we are looking precisely for such exponential decay in the light curves of long-duration GRBs observed with the X-ray telescope (XRT) instrument on the Swift satellite. We found out that almost 30 per cent of XRT light curves show such behaviour before they reach the afterglow plateau. According to Blandford & Znajek, the duration of the burst depends on the magnetic flux accumulated on the event horizon. This allows us to estimate the surface magnetic field of a possible progenitor. Our estimations are consistent with magnetic fields observed in Wolf-Rayet stars.

  14. Auger decay mechanism in photon-stimulated desorption of ions from surfaces

    SciTech Connect

    Parks, C.C.

    1983-11-01

    Photon-stimulated desorption (PSD) of positive ions was studied with synchrotron radiation using an angle-integrating time-of-flight mass spectrometer. Ion yields as functions of photon energy near core levels were measured from condensed gases, alkali fluorides, and other alkali and alkaline earth halides. These results are compared to bulk photoabsorption measurements with emphasis on understanding fundamental desorption mechanisms. The applicability of the Auger decay mechanism, in which ion desorption is strictly proportional to surface absorption, is discussed in detail. The Auger decay model is developed in detail to describe Na/sup +/ and F/sup +/ desorption from NaF following Na(1s) excitation. The major decay pathways of the Na(1s) hole leading to desorption are described and equations for the energetics of ion desorption are developed. Ion desorption spectra of H/sup +/, Li/sup +/, and F/sup +/ are compared to bulk photoabsorption near the F(2s) and Li(1s) edges of LiF. A strong photon beam exposure dependence of ion yields from alkali fluorides is revealed, which may indicate the predominance of metal ion desorption from defect sites. The large role of indirect mechanisms in ion desorption condensed N/sub 2/-O/sub 2/ multilayers is demonstrated and discussed. Ion desorption spectra from several alkali halides and alkaline earth halides are compared to bulk photoabsorption spectra. Relative ion yields from BaF/sub 2/ and a series of alkali halides are discussed in terms of desorption mechanisms.

  15. Inverted xerographic depletion discharge mechanism for the dark decay of electrostatic surface potential on amorphous semiconductors

    SciTech Connect

    Kasap, S.O.

    1988-07-01

    Recently, the xerographic depletion discharge (XDD) model has been applied extensively to chemically modified a-Se, a-Se/sub 1/..sqrt../sub x/Te/sub x/ alloys, and a-As/sub 2/Se/sub 3/ as well as to a-Si:H films to study the nature of charge carrier generation from deep mobility gap states which control the dark decay of the electrostatic surface potential on a corona charged amorphous semiconductor. In the normal XDD model, the dark discharge involves bulk thermal generation of a mobile carrier of the same sign as the surface charge and its subsequent sweep out from the sample leaving behind an ionized center of opposite charge. It is shown that an ''inverted depletion discharge'' mechanism, which involves the thermal generation of a mobile charge carrier of the opposite sign to the surface charge and its subsequent drift to the surface and the resulting surface charge neutralization there, results in a dark discharge rate which has identical features as the normal XDD mechanism. In the normal XDD mechanism, the neutral region develops after the depletion time from the grounded electrode, whereas in the inverted XDD mechanism the neutral region grows from the surface. Furthermore, during inverted depletion discharge the surface charge is actually dissipated by neutralization, whereas in the normal depletion discharge model there is no such requirement over the time scale of the experiment. It is concluded that xerographic dark decay experiments alone cannot determine the sign of the thermally generated mobile carrier and that of the bulk space charge. Chemically modified amorphous selenium case is discussed as an example of surface potential decay resulting from bulk space-charge buildup.

  16. Mechanism of decay of the cry1Aa mRNA in Bacillus subtilis.

    PubMed Central

    Vázquez-Cruz, C; Olmedo-Alvarez, G

    1997-01-01

    We undertook the study of the decay process of the cry1Aa mRNA of Bacillus thuringiensis expressed in B. subtilis. The cry1Aa transcript is a 3.7-kb mRNA expressed during sporulation whose transcriptional control has previously been studied in both B. subtilis and B. thuringiensis. We found that the cry1Aa mRNA has a half-life of around 9 min and that its decay occurs through endoribonucleolytic cleavages which result in three groups of high-molecular-weight mRNA intermediates ranging in size from 2.7 to 0.5 kb. A comparative study carried out with Escherichia coli showed a similar pattern of degradation intermediates. Primer extension analysis carried out on RNA from B. subtilis revealed that most cleavages occur within two regions located toward the 5' and 3' ends of the mRNA. The most prominent processing site observed for the cry1Aa mRNA isolated from B. subtilis is only two bases away from that occurring on RNA isolated from E. coli. Most cleavage sites occur at seemingly single-stranded RNA segments rich in A and U nucleotides, suggesting that a common and conserved mechanism may process the cry1Aa mRNA. PMID:9335281

  17. Supersymmetric type-III seesaw mechanism: Lepton flavor violating decays and dark matter

    SciTech Connect

    Esteves, J. N.; Romao, J. C.; Hirsch, M.

    2011-01-01

    We study a supersymmetric version of the seesaw mechanism type III. The model consists of the minimal supersymmetric extension of the standard model particle content plus three copies of 24 superfields. The fermionic part of the SU(2) triplet contained in the 24 is responsible for the type-III seesaw, which is used to explain the observed neutrino masses and mixings. Complete copies of 24 are introduced to maintain gauge coupling unification. These additional states change the beta functions of the gauge couplings above the seesaw scale. Using minimal Supergravity boundary conditions, we calculate the resulting supersymmetric mass spectra at the electroweak scale using full 2-loop renormalization group equations. We show that the resulting spectrum can be quite different compared to the usual minimal Supergravity spectrum. We discuss how this might be used to obtain information on the seesaw scale from mass measurements. Constraints on the model space due to limits on lepton flavour violating decays are discussed. The main constraints come from the bounds on {mu}{yields}e{gamma} but there are also regions where the decay {tau}{yields}{mu}{gamma} gives stronger constraints. We also calculate the regions allowed by the dark matter constraint. For the sake of completeness, we compare our results with those for the supersymmetric seesaw type II and, to some extent, with type I.

  18. Evolution of novel wood decay mechanisms in Agaricales revealed by the genome sequences of Fistulina hepatica and Cylindrobasidium torrendii

    PubMed Central

    Floudas, Dimitrios; Held, Benjamin W.; Riley, Robert; Nagy, Laszlo G.; Koehler, Gage; Ransdell, Anthony S.; Younus, Hina; Chow, Julianna; Chiniquy, Jennifer; Lipzen, Anna; Tritt, Andrew; Sun, Hui; Haridas, Sajeet; LaButti, Kurt; Ohm, Robin A.; Kües, Ursula; Blanchette, Robert A.; Grigoriev, Igor V.; Minto, Robert E.; Hibbett, David S.

    2015-01-01

    Wood decay mechanisms in Agaricomycotina have been traditionally separated in two categories termed white and brown rot. Recently the accuracy of such a dichotomy has been questioned. Here, we present the genome sequences of the white rot fungus Cylindrobasidium torrendii and the brown rot fungus Fistulina hepatica both members of Agaricales, combining comparative genomics and wood decay experiments. Cylindrobasidium torrendii is closely related to the white-rot root pathogen Armillaria mellea, while F. hepatica is related to Schizophyllum commune, which has been reported to cause white rot. Our results suggest that C. torrendii and S. commune are intermediate between white-rot and brown-rot fungi, but at the same time they show characteristics of decay that resembles soft rot. Both species cause weak wood decay and degrade all wood components but leave the middle lamella intact. Their gene content related to lignin degradation is reduced, similar to brown-rot fungi, but both have maintained a rich array of genes related to carbohydrate degradation, similar to white-rot fungi. These characteristics appear to have evolved from white-rot ancestors with stronger ligninolytic ability. Fistulina hepatica shows characteristics of brown rot both in terms of wood decay genes found in its genome and the decay that it causes. However, genes related to cellulose degradation are still present, which is a plesiomorphic characteristic shared with its white-rot ancestors. Four wood degradation-related genes, homologs of which are frequently lost in brown-rot fungi, show signs of pseudogenization in the genome of F. hepatica. These results suggest that transition towards a brown rot lifestyle could be an ongoing process in F. hepatica. Our results reinforce the idea that wood decay mechanisms are more diverse than initially thought and that the dichotomous separation of wood decay mechanisms in Agaricomycotina into white rot and brown rot should be revisited. PMID:25683379

  19. Evolution of novel wood decay mechanisms in Agaricales revealed by the genome sequences of Fistulina hepatica and Cylindrobasidium torrendii.

    PubMed

    Floudas, Dimitrios; Held, Benjamin W; Riley, Robert; Nagy, Laszlo G; Koehler, Gage; Ransdell, Anthony S; Younus, Hina; Chow, Julianna; Chiniquy, Jennifer; Lipzen, Anna; Tritt, Andrew; Sun, Hui; Haridas, Sajeet; LaButti, Kurt; Ohm, Robin A; Kües, Ursula; Blanchette, Robert A; Grigoriev, Igor V; Minto, Robert E; Hibbett, David S

    2015-03-01

    Wood decay mechanisms in Agaricomycotina have been traditionally separated in two categories termed white and brown rot. Recently the accuracy of such a dichotomy has been questioned. Here, we present the genome sequences of the white-rot fungus Cylindrobasidium torrendii and the brown-rot fungus Fistulina hepatica both members of Agaricales, combining comparative genomics and wood decay experiments. C. torrendii is closely related to the white-rot root pathogen Armillaria mellea, while F. hepatica is related to Schizophyllum commune, which has been reported to cause white rot. Our results suggest that C. torrendii and S. commune are intermediate between white-rot and brown-rot fungi, but at the same time they show characteristics of decay that resembles soft rot. Both species cause weak wood decay and degrade all wood components but leave the middle lamella intact. Their gene content related to lignin degradation is reduced, similar to brown-rot fungi, but both have maintained a rich array of genes related to carbohydrate degradation, similar to white-rot fungi. These characteristics appear to have evolved from white-rot ancestors with stronger ligninolytic ability. F. hepatica shows characteristics of brown rot both in terms of wood decay genes found in its genome and the decay that it causes. However, genes related to cellulose degradation are still present, which is a plesiomorphic characteristic shared with its white-rot ancestors. Four wood degradation-related genes, homologs of which are frequently lost in brown-rot fungi, show signs of pseudogenization in the genome of F. hepatica. These results suggest that transition toward a brown-rot lifestyle could be an ongoing process in F. hepatica. Our results reinforce the idea that wood decay mechanisms are more diverse than initially thought and that the dichotomous separation of wood decay mechanisms in Agaricomycotina into white rot and brown rot should be revisited. PMID:25683379

  20. Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells

    PubMed Central

    Reyes-Zurita, Fernando J.; Rufino-Palomares, Eva E.; García-Salguero, Leticia; Peragón, Juan; Medina, Pedro P.; Parra, Andrés; Cascante, Marta; Lupiáñez, José A.

    2016-01-01

    Maslinic acid (MA) is a natural triterpene present in high concentrations in the waxy skin of olives. We have previously reported that MA induces apoptotic cell death via the mitochondrial apoptotic pathway in HT29 colon cancer cells. Here, we show that MA induces apoptosis in Caco-2 colon cancer cells via the extrinsic apoptotic pathway in a dose-dependent manner. MA triggered a series of effects associated with apoptosis, including the cleavage of caspases -8 and -3, and increased the levels of t-Bid within a few hours of its addition to the culture medium. MA had no effect on the expression of the Bax protein, release of cytochrome-c or on the mitochondrial membrane potential. This suggests that MA triggered the extrinsic apoptotic pathway in this cell type, as opposed to the intrinsic pathway found in the HT29 colon-cancer cell line. Our results suggest that the apoptotic mechanism induced in Caco-2 may be different from that found in HT29 colon-cancer cells, and that in Caco-2 cells MA seems to work independently of p53. Natural antitumoral agents capable of activating both the extrinsic and intrinsic apoptotic pathways could be of great use in treating colon-cancer of whatever origin. PMID:26751572

  1. Significance of decay mechanism into continuum in dynamical Wannier-Stark ladder

    SciTech Connect

    Nemoto, Yuya; Maeshima, Nobuya; Hino, Ken-ichi

    2013-12-04

    We examine the resonance structure of photodressed electron states of laser-driven Wannier-Stark ladder, namely, dynamic Wannier-Stark ladder, in terms of the excess density of states (DOS) closely related to a lifetime of the state of concern. It is revealed that the resonance structure in the strong laser-field region shows clear dependence on the ratio, η, of a Bloch-frequency to a laser frequency. As the laser strength increases, for η = 1, the excess DOS becomes involved with a lot of newly-growing resonance peaks. This result would be understood from the viewpoint of a Fano-like decay-mechanism caused by a multichannel continuum effect, in marked contrast to the cases of larger η’s; for η = 3, the excess DOS just is found to show a pronounced red-shift of a single dominant peak caused by a single-channel continuum effect.

  2. Inter-kingdom conservation of mechanism of nonsense-mediated mRNA decay

    PubMed Central

    Kerényi, Zoltán; Mérai, Zsuzsanna; Hiripi, László; Benkovics, Anna; Gyula, Péter; Lacomme, Christophe; Barta, Endre; Nagy, Ferenc; Silhavy, Dániel

    2008-01-01

    Nonsense-mediated mRNA decay (NMD) is a quality control system that degrades mRNAs containing premature termination codons. Although NMD is well characterized in yeast and mammals, plant NMD is poorly understood. We have undertaken the functional dissection of NMD pathways in plants. Using an approach that allows rapid identification of plant NMD trans factors, we demonstrated that two plant NMD pathways coexist, one eliminates mRNAs with long 3′UTRs, whereas a distinct pathway degrades mRNAs harbouring 3′UTR-located introns. We showed that UPF1, UPF2 and SMG-7 are involved in both plant NMD pathways, whereas Mago and Y14 are required only for intron-based NMD. The molecular mechanism of long 3′UTR-based plant NMD resembled yeast NMD, whereas the intron-based NMD was similar to mammalian NMD, suggesting that both pathways are evolutionarily conserved. Interestingly, the SMG-7 NMD component is targeted by NMD, suggesting that plant NMD is autoregulated. We propose that a complex, autoregulated NMD mechanism operated in stem eukaryotes, and that despite aspect of the mechanism being simplified in different lineages, feedback regulation was retained in all kingdoms. PMID:18451801

  3. A program for undergraduate research into the mechanisms of sensory coding and memory decay

    SciTech Connect

    Calin-Jageman, R J

    2010-09-28

    This is the final technical report for this DOE project, entitltled "A program for undergraduate research into the mechanisms of sensory coding and memory decay". The report summarizes progress on the three research aims: 1) to identify phyisological and genetic correlates of long-term habituation, 2) to understand mechanisms of olfactory coding, and 3) to foster a world-class undergraduate neuroscience program. Progress on the first aim has enabled comparison of learning-regulated transcripts across closely related learning paradigms and species, and results suggest that only a small core of transcripts serve truly general roles in long-term memory. Progress on the second aim has enabled testing of several mutant phenotypes for olfactory behaviors, and results show that responses are not fully consistent with the combinitoral coding hypothesis. Finally, 14 undergraduate students participated in this research, the neuroscience program attracted extramural funding, and we completed a successful summer program to enhance transitions for community-college students into 4-year colleges to persue STEM fields.

  4. Two-step mechanisms of two-proton decays of nuclei

    NASA Astrophysics Data System (ADS)

    Kadmensky, S. G.; Ivankov, Yu. V.

    2014-08-01

    A formalism for describing two-step two-proton decays of nuclei is developed on the basis of the multiparticle theory of deep-subbarrier one-proton decays of nuclei that employs integral expression for the decay widths in question. This formalism relies on the idea that the interaction between the emitted protons has but a slight effect on the widths with respect to the two-proton decays being considered. It is shown that such a decay is naturally broken down into the sequential one-proton decays of an ( A, Z) parent nucleus and an ( A - 1, Z - 1) intermediate nucleus, these decays being related by the Green's function G( A - 1, Z - 1) that describes the intermediate nucleus with allowance for its real and virtual states, which give rise to, respectively, the sequential and the virtual two-step two-proton decay of the parent nucleus. It is also shown that the widths with respect to sequential two-step two-proton decays coincide with the analogous widths constructed within the R-matrix theory of nuclear reactions leading to the production of unstable particles and with their counterparts obtained with the aid of solving the set of kinetic equations for the chain of nuclei undergoing radioactive decays. It is found that the widths with respect to virtual two-step two-proton decays are close in structure to the widths constructed for the simultaneous two-proton decays of nuclei by using integrated formulas within a simplified model of the method of three-particle hyperspherical polynomials.

  5. MALDI In-Source Decay of Protein: The Mechanism of c-Ion Formation

    PubMed Central

    Takayama, Mitsuo

    2016-01-01

    The in-source decay (ISD) phenomenon, the fragmentation at an N–Cα bond of a peptide backbone that occurs within several tens of nanoseconds in the ion-source in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS), is discussed from the standpoints of the discovery and early publications dealing with MALDI-ISD, the formation of c-ions in energy-sudden desorption/ionization methods, the formation of radical species in a MALDI, model construction for ISD, and matrix materials that are suitable for use in MALDI-ISD. The formation of c-ions derived from peptides and proteins in MALDI-ISD can be rationalized by a mechanism involving intermolecular hydrogen transfer, denoted as the “Takayama’s model” by De Pauw’s group (Anal. Chem. 79: 8678–8685, 2007). It should be emphasized that the model for MALDI-ISD was constructed on the basis of X-ray crystallography and scanning probe microscopy (SPM) analyses of matrix crystals, as well as the use of isotopically-labelled peptides. PMID:27162707

  6. MALDI In-Source Decay of Protein: The Mechanism of c-Ion Formation.

    PubMed

    Takayama, Mitsuo

    2016-01-01

    The in-source decay (ISD) phenomenon, the fragmentation at an N-Cα bond of a peptide backbone that occurs within several tens of nanoseconds in the ion-source in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS), is discussed from the standpoints of the discovery and early publications dealing with MALDI-ISD, the formation of c-ions in energy-sudden desorption/ionization methods, the formation of radical species in a MALDI, model construction for ISD, and matrix materials that are suitable for use in MALDI-ISD. The formation of c-ions derived from peptides and proteins in MALDI-ISD can be rationalized by a mechanism involving intermolecular hydrogen transfer, denoted as the "Takayama's model" by De Pauw's group (Anal. Chem. 79: 8678-8685, 2007). It should be emphasized that the model for MALDI-ISD was constructed on the basis of X-ray crystallography and scanning probe microscopy (SPM) analyses of matrix crystals, as well as the use of isotopically-labelled peptides. PMID:27162707

  7. Influence of heat treatments upon the mechanical properties and in vitro bioactivity of ZrO2-toughened MgO-CaO-SiO2-P2O5-CaF2 glass-ceramics.

    PubMed

    Li, Huan-Cai; Wang, Dian-Gang; Meng, Xiang-Guo; Chen, Chuan-Zhong

    2014-09-01

    Zirconia-toughened MgO-CaO-SiO2-P2O5-CaF2 glass-ceramics are prepared using sintering techniques, and a series of heat treatment procedures are designed to obtain a glass-ceramic with improved properties. The crystallization behavior, phase composition, and morphology of the glass-ceramics are characterized. The bending strength, elastic modulus, fracture toughness, and microhardness of the glass-ceramics are investigated, and the effect mechanism of heat treatments upon the mechanical properties is discussed. The bioactivity of glass-ceramics is then evaluated using the in vitro simulated body fluid (SBF) soaking test, and the mechanism whereby apatite forms on the glass-ceramic surfaces in the SBF solution is discussed. The results indicate that the main crystal phase of the G-24 sample undergoing two heat treatment procedures is Ca5(PO4)3F (fluorapatite), and those of the G-2444 sample undergoing four heat treatment procedures are Ca5(PO4)3F and β-CaSiO3 (β-wollastonite). The heat treatment procedures are found to greatly influence the mechanical properties of the glass-ceramic, and an apatite layer is induced on the glass-ceramic surface after soaking in the SBF solution. PMID:25280855

  8. Non-adiabatic dynamics investigation of the radiationless decay mechanism of trans-urocanic acid in the S2 state.

    PubMed

    Zhao, Li; Zhou, Pan-Wang; Zhao, Guang-Jiu

    2016-07-28

    The trans-urocanic acid, a UV chromophore in the epidermis of human skin, was found to exhibit a wavelength dependent isomerization property. The isomerization quantum yield to cis-urocanic is greatest when being excited to the S1 state, whereas exciting the molecule to the S2 state causes almost no isomerization. The comparative photochemical behavior of the trans-urocanic on the S1 and S2 states continues to be the subject of intense research effort. This study is concerned with the unique photo-behavior of this interesting molecule on the S2 state. Combining the on-the-fly surface hopping dynamics simulations and static electronic structure calculations, three decay channels were observed following excitation to the S2 state. An overwhelming majority of the molecules decay to the S1 state through a planar or pucker characterized minimum energy conical intersection (MECI), and then decay to the ground state along a relaxation coordinate driven by a pucker deformation of the ring. A very small fraction of molecules decay to the S1 state by a MECI characterized by a twisting motion around the CC double bond, which continues to drive the molecule to deactivate to the ground state. The latter channel is related with the photoisomerization process, whereas the former one will only generate the original trans-form products. The present work provides a novel S2 state decay mechanism of this molecule, which offers useful information to explain the wavelength dependent isomerization behavior. PMID:27475370

  9. Non-adiabatic dynamics investigation of the radiationless decay mechanism of trans-urocanic acid in the S2 state

    NASA Astrophysics Data System (ADS)

    Zhao, Li; Zhou, Pan-Wang; Zhao, Guang-Jiu

    2016-07-01

    The trans-urocanic acid, a UV chromophore in the epidermis of human skin, was found to exhibit a wavelength dependent isomerization property. The isomerization quantum yield to cis-urocanic is greatest when being excited to the S1 state, whereas exciting the molecule to the S2 state causes almost no isomerization. The comparative photochemical behavior of the trans-urocanic on the S1 and S2 states continues to be the subject of intense research effort. This study is concerned with the unique photo-behavior of this interesting molecule on the S2 state. Combining the on-the-fly surface hopping dynamics simulations and static electronic structure calculations, three decay channels were observed following excitation to the S2 state. An overwhelming majority of the molecules decay to the S1 state through a planar or pucker characterized minimum energy conical intersection (MECI), and then decay to the ground state along a relaxation coordinate driven by a pucker deformation of the ring. A very small fraction of molecules decay to the S1 state by a MECI characterized by a twisting motion around the CC double bond, which continues to drive the molecule to deactivate to the ground state. The latter channel is related with the photoisomerization process, whereas the former one will only generate the original trans-form products. The present work provides a novel S2 state decay mechanism of this molecule, which offers useful information to explain the wavelength dependent isomerization behavior.

  10. Updated constraints on the light-neutrino exchange mechanisms of the 0νββ-decay

    NASA Astrophysics Data System (ADS)

    Štefánik, Dušan; Dvornický, Rastislav; Šimkovic, Fedor

    2015-10-01

    The neutrinoless double-beta (0νββ) decay associated with light neutrino exchange mechanisms, which are due to both left-handed V-A and right-handed V+A leptonic and hadronic currents, is discussed by using the recent progress achieved by the GERDA, EXO and KamlandZen experiments. The upper limits for effective neutrino mass mββ and the parameters <λ> and <η> characterizing the right handed current mechanisms are deduced from the data on the 0νββ-decay of 76Ge and 136Xe using nuclear matrix elements calculated within the nuclear shell model and quasiparticle random phase approximation and phase-space factors calculated with exact Dirac wave functions with finite nuclear size and electron screening. The careful analysis of upper constraints on effective lepton number violating parameters assumes a competition of the above mechanisms and arbitrary values of involved CP violating phases.

  11. Proton-transfer mechanism for dispersed decay kinetics of single molecules isolated in potassium hydrogen phthalate.

    PubMed

    Bott, Eric D; Riley, Erin A; Kahr, Bart; Reid, Philip J

    2009-08-25

    The excited-state decay kinetics of single 2',7'-dichlorofluorescein (DCF) molecules oriented and overgrown within crystals of potassium acid phthalate (KAP) are reported. Time-correlated single-photon counting measurements (TCSPC) of 56 DCF molecules in KAP reveal that single-exponential decay is exhibited by roughly half of the molecules. The remainder demonstrates complex excited-state decay kinetics that are well fit by a stretched exponential function consistent with dispersed kinetics. Histograms of single-molecule luminescence energies revealed environmental fluctuations and distinct chemical species. The TCSPC results are compared to Monte Carlo simulations employing a first-passage model for excited-state decay. Agreement between experiment and theory, on both bulk and single-molecule levels, suggests that a subset of the DCF molecules in KAP experience fluctuations in the surrounding environment that modify the energy barrier to proton transfer leading to dispersed kinetics. PMID:19658424

  12. Mechanism of the Decay of Thymine Triplets in DNA Single Strands.

    PubMed

    Pilles, Bert M; Bucher, Dominik B; Liu, Lizhe; Clivio, Pascale; Gilch, Peter; Zinth, Wolfgang; Schreier, Wolfgang J

    2014-05-01

    The decay of triplet states and the formation of cyclobutane pyrimidine dimers (CPDs) after UV excitation of the all-thymine oligomer (dT)18 and the locked dinucleotide TLpTL were studied by nanosecond IR spectroscopy. IR marker bands characteristic for the CPD lesion and the triplet state were observed from ∼1 ns (time resolution of the setup) onward. The amplitudes of the CPD marker bands remain constant throughout the time range covered (up to 10 μs). The triplet decays with a time constant of ∼10 ns presumably via a biradical intermediate (lifetime ∼60 ns). This biradical has often been invoked as an intermediate for CPD formation via the triplet channel. The present results lend strong support to the existence of this intermediate, yet there is no indication that its decay contributes significantly to CPD formation. PMID:26270105

  13. 2p2 Team News

    NASA Astrophysics Data System (ADS)

    Jones, H.

    2000-12-01

    In September we welcomed new team member Lisa Germany from Australia. Lisa is a new ESO Fellow and has interests in supernovae and their use in cosmological distance determinations. S e p t e m b e r, however, was also a month for departures when we said goodbye to long-time team member James Brewer. James was a pivotal member of the 2p2 Team since his arrival at ESO in 1996. He has returned to Canada to take up a position at the University of British Columbia, in Vancouver, Canada. We wish him all the best under northern skies.

  14. 2p2 Team News

    NASA Astrophysics Data System (ADS)

    Jones, H.

    2000-06-01

    The 2p2 Team continued towards the implementation at the 2.2-m of the same BOB (Broker for Observation Blocks) observing interface as seen at other ESO telescopes. This requires an interface to be written between the existing BOB software and the non-VLT compatible control software for the Wide-Field Imager (WFI) and 2.2-m. Cristian Urrutia, Tatiana Paz and Eduardo Robledo are heading its development. With this software in place, observers can use the VLT Phase 2 Proposal Preparation System (P2PP) for definition of their exposures, whether they are for Visitor or Service Mode.

  15. Effect of ZrO(2) additions on the crystallization, mechanical and biological properties of MgO-CaO-SiO(2)-P(2)O(5)-CaF(2) bioactive glass-ceramics.

    PubMed

    Li, H C; Wang, D G; Meng, X G; Chen, C Z

    2014-06-01

    A series of ZrO(2) doped MgO-CaO-SiO(2)-P(2)O(5)-CaF(2) bioactive glass-ceramics were obtained by sintering method. The crystallization behavior, phase composition, morphology and structure of glass-ceramics were characterized. The bending strength, elastic modulus, fracture toughness, micro-hardness and thermal expansion coefficient (TEC) of glass-ceramics were investigated. The in vitro bioactivity and cytotoxicity tests were used to evaluate the bioactivity and biocompatibility of glass-ceramics. The sedimentation mechanism and growth process of apatites on sample surface were discussed. The results showed that the mainly crystalline phases of glass-ceramics were Ca(5)(PO4)3F (fluorapatite) and β-CaSiO(3). (β-wollastonite). m-ZrO(2) (monoclinic zirconia) declined the crystallization temperatures of glasses. t-ZrO(2) (tetragonal zirconia) increased the crystallization temperature of Ca(5)(PO4)(3)F and declined the crystallization temperature of β-CaSiO(3). t-ZrO(2) greatly increased the fracture toughness, bending strength and micro-hardness of glass-ceramics. The nanometer apatites were induced on the surface of glass-ceramic after soaking 28 days in SBF (simulated body fluid), indicating the glass-ceramic has good bioactivity. The in vitro cytotoxicity test demonstrated the glass-ceramic has no toxicity to cell. PMID:24780435

  16. Angiopoietin-1 attenuates angiotensin II-induced ER stress in glomerular endothelial cells via a Tie2 receptor/ERK1/2-p38 MAPK-dependent mechanism.

    PubMed

    Bi, Xiao; Niu, Jianying; Ding, Wei; Zhang, Minmin; Yang, Min; Gu, Yong

    2016-06-15

    Research has indicated that endoplasmic reticulum (ER) stress in endothelial cells affects vascular pathologies and induces cellular dysfunction and apoptosis. Angiopoietin1 (Angpt1) has been shown to have therapeutic potential in some vascular diseases, including chronic kidney disease. This study showed that Angpt1 is a powerful factor that attenuated ER stress-induced cellular dysfunction and apoptosis in glomerular endothelial cells (GEnCs). Furthermore, Angpt1 significantly decreased the angiotensin II (Ang II)-induced expression of the ER stress response proteins GRP78, GRP94, p-PERK and CHOP. These results suggest that the Angpt1-mediated cellular protection may occur downstream of the ER stress response. In addition, both specific inhibitors and siRNAs for Tie2 reversed these changes, implying the importance of Tie2 receptor activation in the signalling pathways that prevent ER stress. The protective effects of Angpt1 are related to the activation of two downstream signalling pathways, ERK1/2 and p38 MAPK. The inhibition of these pathways with specific inhibitors, PD98059 and SB203580, respectively, partially increased the expression of chaperones that assist in folding proteins in the ER and reduce the protective effects of Angpt1. In conclusion, Angpt1 attenuated ER stress-induced cellular dysfunction and apoptosis via the Tie2 receptor/ERK1/2-p38 MAPK pathways in GEnCs. This study may provide insights into a novel underlying mechanism and a strategy for alleviating ER stress-induced injury. PMID:27033326

  17. Capacity decay mechanism of microporous separator-based all-vanadium redox flow batteries and its recovery.

    PubMed

    Li, Bin; Luo, Qingtao; Wei, Xiaoliang; Nie, Zimin; Thomsen, Edwin; Chen, Baowei; Sprenkle, Vincent; Wang, Wei

    2014-02-01

    The results of the investigation of the capacity decay mechanism of vanadium redox flow batteries with microporous separators as membranes are reported. The investigation focuses on the relationship between the electrochemical performance and electrolyte compositions at both the positive and negative half-cells. Although the concentration of total vanadium ions remains nearly constant at both sides over cycling, the net transfer of solution from one side to the other and thus the asymmetrical valance of vanadium ions caused by the subsequent disproportionate self-discharge reactions at both sides lead to capacity fading. Through in situ monitoring of the hydraulic pressure of the electrolyte during cycling at both sides, the convection was found to arise from differential hydraulic pressures at both sides of the separators and plays a dominant role in capacity decay. A capacity-stabilizing method is developed and was successfully demonstrated through the regulation of gas pressures in both electrolyte tanks. PMID:24488680

  18. Lepton flavor violating {tau} decays in the type-III seesaw mechanism

    SciTech Connect

    Arhrib, Abdesslam; Benbrik, Rachid; Chen, C.-H.

    2010-06-01

    In this paper, the lepton flavor violating {tau}{yields}lP(V) (P, V={pi}{sup 0}, {eta}, {eta}{sup '}, {rho}{sup 0}, {omega}, {phi}) and {tau}{yields}3l (l=e, {mu}) decays are studied in the framework of the type-III seesaw model, in which new triplet fermions with a zero hypercharge (Y=0) interact with ordinary lepton doublets via Yukawa couplings, and affect tree-level leptonic Z-boson couplings. We investigate the experimental bound from the leptonic Z decay to get constraints on the existing parameters space. We predict that the upper limits on the branching ratios of {tau}{yields}lP(V) and {tau}{yields}3l can reach the experimental current limits.

  19. Evolutionary Perspectives on Diversity of Lignocellulose Decay Mechanisms in Basidionycetes (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    ScienceCinema

    Hibbett, David [Clark University

    2013-01-15

    David Hibbett from Clark University on "Evolutionary Perspectives on Diversity of Lignocellulose Decay Mechanisms in Basidiomycetes" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, California.

  20. Evolutionary Perspectives on Diversity of Lignocellulose Decay Mechanisms in Basidionycetes (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    SciTech Connect

    Hibbett, David

    2012-03-21

    David Hibbett from Clark University on "Evolutionary Perspectives on Diversity of Lignocellulose Decay Mechanisms in Basidiomycetes" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, California.

  1. Updated constraints on the light-neutrino exchange mechanisms of the 0νββ-decay

    SciTech Connect

    Štefánik, Dušan; Dvornický, Rastislav; Šimkovic, Fedor

    2015-10-28

    The neutrinoless double-beta (0νββ) decay associated with light neutrino exchange mechanisms, which are due to both left-handed V-A and right-handed V+A leptonic and hadronic currents, is discussed by using the recent progress achieved by the GERDA, EXO and KamlandZen experiments. The upper limits for effective neutrino mass m{sub ββ} and the parameters 〈λ〉 and 〈η〉 characterizing the right handed current mechanisms are deduced from the data on the 0νββ-decay of {sup 76}Ge and {sup 136}Xe using nuclear matrix elements calculated within the nuclear shell model and quasiparticle random phase approximation and phase-space factors calculated with exact Dirac wave functions with finite nuclear size and electron screening. The careful analysis of upper constraints on effective lepton number violating parameters assumes a competition of the above mechanisms and arbitrary values of involved CP violating phases.

  2. Laser studies of radiationless decay mechanisms in Os/sup 2 +///sup 3 +/ polypyridine complexes

    SciTech Connect

    Netzel, T.L.; Bergkamp, M.A.

    1982-01-01

    The lowest energy excited states in Os(II) polypyridine complexes are of a metal-to-ligand charge transfer (MLCT) type and live for 10 to 40 ..mu..s at 4.2/sup 0/K. The long wavelength absorptions in the visible region of the spectrum in Os(III) polypyridine complexes arise from ligand-to-metal charge transfer (LMCT) transitions and do not produce detectable luminescence. This suggests that these LMCT states are very short lived. Results of picosecond absorption studies on the lifetimes the LMCT states in OsL/sub 3//sup 3 +/ complexes (L = 2,2'-bipyridine(bpy) or 1,10-phenanthroline(phen)) as functions of temperature and isotopic substitution are reported. The LMCT lifetimes at low temperature are contrasted with the low temperature lifetimes of the MLCT states of OsL/sub 3//sup 2 +/ complexes and both are examined from the perspective of a coarse-grained radiationless decay theory developed by Englman, R. and Jortner, J. (Molec. Phys. 1970, 18, 145). The agreement between experiment and theory suggests the following: (1) Englman and Jortner's theory of radiationless decay is useful for inorganic as well as organic systems; (2) mid-frequency (1300 to 1600 cm/sup -1/) vibrations are the important energy accepting modes for radiationless decay of the charge transfer excited states of OsL/sub 3//sup 2 +///sup 3 +/ complexes and; (3) the 10/sup 5/-10/sup 6/ difference in lifetimes between the MLCT states of OsL/sub 3//sup 2 +/ complexes and the LMCT states of OsL/sub 3//sup 3 +/ complexes is largely due to the difference in their energy gaps.

  3. Decay Mechanism of 290,292114* Superheavy Nuclei Formed in 48Ca-Induced Reactions

    NASA Astrophysics Data System (ADS)

    Sandhu, Kirandeep; Sharma, Manoj K.

    2013-10-01

    We calculate the neutron-evaporation residue cross sections σ 3n , σ 4n , and σ 5n in the hot-fusion reactions 48Ca+242,244Pu →290,292114 ∗ over a wide range of compound-nucleus excitation energies (E_{{CN}}^{*} = 34-53 MeV). We work with the dynamical cluster-decay model (DCM), with a single parameter, the neck-length parameter ΔR. To calculate neutron-evaporation cross sections, we choose the superheavy proton magic Z = 126 and neutron magic N = 184. Among the 3n, 4n, and 5n production cross sections for 290, 292114∗, only the 3n decay cross sections of 292114∗ correspond to spherical fragmentation. The 4n and 5n cross sections of 292114∗ and 3n, 4n, and 5n cross sections of 290114∗ could only be fitted after the inclusion of quadrupole deformations β 2i within the optimum orientation approach. Changes in the angular momentum and N/Z ratio do not significantly influence the fragmentation paths of 290, 292114∗ superheavy nuclei. Larger barrier modification is required for the lower angular momentum states and lighter neutron clusters. The contribution of the fusion-fission component is also computed for the compound nucleus 292114∗ in the energy range E_{{CN}}^{*} = 27-47 MeV.

  4. N(2P) in the dayglow - Measurement and theory

    NASA Technical Reports Server (NTRS)

    Torr, Marsha R.; Torr, Douglas G.; Richards, P. G.

    1993-01-01

    During the ATLAS-1 mission, the first dayglow altitude profiles were obtained of the N(2P) emission at 3466 A. These observations were made in the sunlit thermosphere using the Imaging Spectrometric Observatory. As all previous work on this emission has been done under auroral conditions, this study represents the first examination of the photochemical sources and sinks of N(2P) in the normal daytime thermospheric, with comparison with measurements. We find that the observations are explained by a model in which the major source is photodissociation of N2, and quenching by O is the principal low-altitude loss process, with radiative decay to N(2D) dominating above 200 km. As the dominant loss processes are likely to result in the production of N(2D), N(2P) could be a moderate source of N(2D) and may be a factor to be taken into consideration in modeling NO.

  5. Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in mycorrhizal mutualists

    SciTech Connect

    Kohler, Annegret; Kuo, Alan; Nagy, Laszlo G.; Morin, Emmanuelle; Barry, Kerrie W.; Buscot, Francois; Canbäck, Björn; Choi, Cindy; Cichocki, Nicolas; Clum, Alicia; Colpaert, Jan; Copeland, Alex; Costa, Mauricio D.; Doré, Jeanne; Floudas, Dimitrios; Gay, Gilles; Girlanda, Mariangela; Henrissat, Bernard; Herrmann, Sylvie; Hess, Jaqueline; Högberg, Nils; Johansson, Tomas; Khouja, Hassine-Radhouane; LaButti, Kurt; Lahrmann, Urs; Levasseur, Anthony; Lindquist, Erika A.; Lipzen, Anna; Marmeisse, Roland; Martino, Elena; Murat, Claude; Ngan, Chew Y.; Nehls, Uwe; Plett, Jonathan M.; Pringle, Anne; Ohm, Robin A.; Perotto, Silvia; Peter, Martina; Riley, Robert; Rineau, Francois; Ruytinx, Joske; Salamov, Asaf; Shah, Firoz; Sun, Hui; Tarkka, Mika; Tritt, Andrew; Veneault-Fourrey, Claire; Zuccaro, Alga; Tunlid, Anders; Grigoriev, Igor V.; Hibbett, David S.; Martin, Francis

    2015-02-23

    To elucidate the genetic bases of mycorrhizal lifestyle evolution, we sequenced new fungal genomes, including 13 ectomycorrhizal (ECM), orchid (ORM) and ericoid (ERM) species, and five saprotrophs, which we analyzed along with other fungal genomes. Ectomycorrhizal fungi have a reduced complement of genes encoding plant cell wall-degrading enzymes (PCWDEs), as compared to their ancestral wood decayers. Nevertheless, they have retained a unique array of PCWDEs, thus suggesting that they possess diverse abilities to decompose lignocellulose. Similar functional categories of nonorthologous genes are induced in symbiosis. Of induced genes, 7-38% are orphan genes, including genes that encode secreted effector-like proteins. Convergent evolution of the mycorrhizal habit in fungi occurred via the repeated evolution of a 'symbiosis toolkit', with reduced numbers of PCWDEs and lineage-specific suites of mycorrhiza-induced genes.

  6. Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in mycorrhizal mutualists

    DOE PAGESBeta

    Kohler, Annegret; Kuo, Alan; Nagy, Laszlo G.; Morin, Emmanuelle; Barry, Kerrie W.; Buscot, Francois; Canbäck, Björn; Choi, Cindy; Cichocki, Nicolas; Clum, Alicia; et al

    2015-02-23

    To elucidate the genetic bases of mycorrhizal lifestyle evolution, we sequenced new fungal genomes, including 13 ectomycorrhizal (ECM), orchid (ORM) and ericoid (ERM) species, and five saprotrophs, which we analyzed along with other fungal genomes. Ectomycorrhizal fungi have a reduced complement of genes encoding plant cell wall-degrading enzymes (PCWDEs), as compared to their ancestral wood decayers. Nevertheless, they have retained a unique array of PCWDEs, thus suggesting that they possess diverse abilities to decompose lignocellulose. Similar functional categories of nonorthologous genes are induced in symbiosis. Of induced genes, 7-38% are orphan genes, including genes that encode secreted effector-like proteins. Convergentmore » evolution of the mycorrhizal habit in fungi occurred via the repeated evolution of a 'symbiosis toolkit', with reduced numbers of PCWDEs and lineage-specific suites of mycorrhiza-induced genes.« less

  7. Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in mycorrhizal mutualists.

    PubMed

    Kohler, Annegret; Kuo, Alan; Nagy, Laszlo G; Morin, Emmanuelle; Barry, Kerrie W; Buscot, Francois; Canbäck, Björn; Choi, Cindy; Cichocki, Nicolas; Clum, Alicia; Colpaert, Jan; Copeland, Alex; Costa, Mauricio D; Doré, Jeanne; Floudas, Dimitrios; Gay, Gilles; Girlanda, Mariangela; Henrissat, Bernard; Herrmann, Sylvie; Hess, Jaqueline; Högberg, Nils; Johansson, Tomas; Khouja, Hassine-Radhouane; LaButti, Kurt; Lahrmann, Urs; Levasseur, Anthony; Lindquist, Erika A; Lipzen, Anna; Marmeisse, Roland; Martino, Elena; Murat, Claude; Ngan, Chew Y; Nehls, Uwe; Plett, Jonathan M; Pringle, Anne; Ohm, Robin A; Perotto, Silvia; Peter, Martina; Riley, Robert; Rineau, Francois; Ruytinx, Joske; Salamov, Asaf; Shah, Firoz; Sun, Hui; Tarkka, Mika; Tritt, Andrew; Veneault-Fourrey, Claire; Zuccaro, Alga; Tunlid, Anders; Grigoriev, Igor V; Hibbett, David S; Martin, Francis

    2015-04-01

    To elucidate the genetic bases of mycorrhizal lifestyle evolution, we sequenced new fungal genomes, including 13 ectomycorrhizal (ECM), orchid (ORM) and ericoid (ERM) species, and five saprotrophs, which we analyzed along with other fungal genomes. Ectomycorrhizal fungi have a reduced complement of genes encoding plant cell wall-degrading enzymes (PCWDEs), as compared to their ancestral wood decayers. Nevertheless, they have retained a unique array of PCWDEs, thus suggesting that they possess diverse abilities to decompose lignocellulose. Similar functional categories of nonorthologous genes are induced in symbiosis. Of induced genes, 7-38% are orphan genes, including genes that encode secreted effector-like proteins. Convergent evolution of the mycorrhizal habit in fungi occurred via the repeated evolution of a 'symbiosis toolkit', with reduced numbers of PCWDEs and lineage-specific suites of mycorrhiza-induced genes. PMID:25706625

  8. Photon-stimulated ion desorption from molybdenum oxides following Mo 2p3/2 excitation.

    PubMed

    Wu, G; Baba, Y; Sekiguchi, T; Shimoyama, I

    2001-03-01

    Photon-stimulated ion desorption from solid MoO3 following the Mo 2p3/2 resonant transition has been investigated. In the XANES spectrum, Mo 2p3/2 peak is split into two components corresponding to the excitations from Mo 2p3/2 into the t2g and e(g) orbitals. It was observed that the desorption yield of O+ ions at the Mo 2p3/2-->e(g) resonance is higher than that at the Mo 2p3/2-->t2g resonance. The Auger decay spectra reveal that there exist two kinds of spectator Auger decays. The high desorption yield at the 2p3/2-->e(g) resonance is interpreted by the fast breaking of the Mo-O bond due to the localization of the electrons in the highly antibonding e(g). PMID:11512817

  9. A novel Si strip array to investigate reaction and decay mechanisms

    NASA Astrophysics Data System (ADS)

    Stanoiu, M.; Sümmerer, K.; Mukha, I.; Chatillon, A.; Cortina Gil, E.; Heil, M.; Hoffman, J.; Kiselev, O. A.; Kurz, N.; Ott, W.; S271 Collaboration

    2008-10-01

    The performance of a novel set-up of double-sided silicon micro-strip detectors (DSSD) developed for the GSI-R3B project (reaction studies with relativistic radioactive beams) is presented. The set-up was used in an experiment aimed at measuring the two-proton decay of 19Mg. This experiment required to record simultaneously protons and the residual nuclei with good position and energy resolution. Our experimental results show that both protons and heavy ions ranging from Z = 2 up to Z = 12 can be identified with good signal-to-noise ratio and high energy and spatial resolution. This allowed to reconstruct 2- and 3-particle vertices with high precision, opening the possibility to measure lifetimes of very short-lived nuclei and to obtain precise angular correlations of the outgoing particles. This detection system serves as a prototype for the R3B recoil detector, which will be composed of a two-layer Si strip tracker.

  10. Research on biodeterioration of wood, 1987-1992. 1. Decay mechanisms and biocontrol. Forest Service research paper

    SciTech Connect

    Highley, T.L.; Clausen, C.A.; Croan, S.C.; Green, F.; Illman, B.L.

    1994-03-01

    Growing concerns about the environment present an urgent need for new approaches to preserving wood. Some commonly used preservatives have been banned or restricted in several countries. The research paper first describes current knowledge about how white-and-brown rot fungi decay wood and then delineates research in to problem areas: (1) control of wood decay through targeting biosynthetic and degradative pathways, and (2) biological control (biocontrol) of wood decay through non-decay micro-organisms.

  11. Reduced order modeling of mechanical degradation induced performance decay in lithium-ion battery porous electrodes

    DOE PAGESBeta

    Barai, Pallab; Smith, Kandler; Chen, Chien -Fan; Kim, Gi -Heon; Mukherjee, Partha P.

    2015-06-17

    In this paper, a one-dimensional computational framework is developed that can solve for the evolution of voltage and current in a lithium-ion battery electrode under different operating conditions. A reduced order model is specifically constructed to predict the growth of mechanical degradation within the active particles of the carbon anode as a function of particle size and C-rate. Using an effective diffusivity relation, the impact of microcracks on the diffusivity of the active particles has been captured. Reduction in capacity due to formation of microcracks within the negative electrode under different operating conditions (constant current discharge and constant current constantmore » voltage charge) has been investigated. At the beginning of constant current discharge, mechanical damage to electrode particles predominantly occurs near the separator. As the reaction front shifts, mechanical damage spreads across the thickness of the negative electrode and becomes relatively uniform under multiple discharge/charge cycles. Mechanical degradation under different drive cycle conditions has been explored. It is observed that electrodes with larger particle sizes are prone to capacity fade due to microcrack formation. Finally, under drive cycle conditions, small particles close to the separator and large particles close to the current collector can help in reducing the capacity fade due to mechanical degradation.« less

  12. Reduced order modeling of mechanical degradation induced performance decay in lithium-ion battery porous electrodes

    SciTech Connect

    Barai, Pallab; Smith, Kandler; Chen, Chien -Fan; Kim, Gi -Heon; Mukherjee, Partha P.

    2015-06-17

    In this paper, a one-dimensional computational framework is developed that can solve for the evolution of voltage and current in a lithium-ion battery electrode under different operating conditions. A reduced order model is specifically constructed to predict the growth of mechanical degradation within the active particles of the carbon anode as a function of particle size and C-rate. Using an effective diffusivity relation, the impact of microcracks on the diffusivity of the active particles has been captured. Reduction in capacity due to formation of microcracks within the negative electrode under different operating conditions (constant current discharge and constant current constant voltage charge) has been investigated. At the beginning of constant current discharge, mechanical damage to electrode particles predominantly occurs near the separator. As the reaction front shifts, mechanical damage spreads across the thickness of the negative electrode and becomes relatively uniform under multiple discharge/charge cycles. Mechanical degradation under different drive cycle conditions has been explored. It is observed that electrodes with larger particle sizes are prone to capacity fade due to microcrack formation. Finally, under drive cycle conditions, small particles close to the separator and large particles close to the current collector can help in reducing the capacity fade due to mechanical degradation.

  13. Σ--antihyperon correlations in Z0 decay and investigation of the baryon production mechanism

    NASA Astrophysics Data System (ADS)

    Abbiendi, G.; Ainsley, C.; Åkesson, P. F.; Alexander, G.; Anagnostou, G.; Anderson, K. J.; Asai, S.; Axen, D.; Bailey, I.; Barberio, E.; Barillari, T.; Barlow, R. J.; Batley, R. J.; Bechtle, P.; Behnke, T.; Bell, K. W.; Bell, P. J.; Bella, G.; Bellerive, A.; Benelli, G.; Bethke, S.; Biebel, O.; Boeriu, O.; Bock, P.; Boutemeur, M.; Braibant, S.; Brown, R. M.; Burckhart, H. J.; Campana, S.; Capiluppi, P.; Carnegie, R. K.; Carter, A. A.; Carter, J. R.; Chang, C. Y.; Charlton, D. G.; Ciocca, C.; Csilling, A.; Cuffiani, M.; Dado, S.; Dallavalle, M.; de Roeck, A.; de Wolf, E. A.; Desch, K.; Dienes, B.; Dubbert, J.; Duchovni, E.; Duckeck, G.; Duerdoth, I. P.; Etzion, E.; Fabbri, F.; Ferrari, P.; Fiedler, F.; Fleck, I.; Ford, M.; Frey, A.; Gagnon, P.; Gary, J. W.; Geich-Gimbel, C.; Giacomelli, G.; Giacomelli, P.; Giunta, M.; Goldberg, J.; Gross, E.; Grunhaus, J.; Gruwé, M.; Gupta, A.; Hajdu, C.; Hamann, M.; Hanson, G. G.; Harel, A.; Hauschild, M.; Hawkes, C. M.; Hawkings, R.; Herten, G.; Heuer, R. D.; Hill, J. C.; Horváth, D.; Igo-Kemenes, P.; Ishii, K.; Jeremie, H.; Jovanovic, P.; Junk, T. R.; Kanzaki, J.; Karlen, D.; Kawagoe, K.; Kawamoto, T.; Keeler, R. K.; Kellogg, R. G.; Kennedy, B. W.; Kluth, S.; Kobayashi, T.; Kobel, M.; Komamiya, S.; Krämer, T.; Krasznahorkay, A.; Krieger, P.; von Krogh, J.; Kuhl, T.; Kupper, M.; Lafferty, G. D.; Landsman, H.; Lanske, D.; Lellouch, D.; Letts, J.; Levinson, L.; Lillich, J.; Lloyd, S. L.; Loebinger, F. K.; Lu, J.; Ludwig, A.; Ludwig, J.; Mader, W.; Marcellini, S.; Martin, A. J.; Mashimo, T.; Mättig, P.; McKenna, J.; McPherson, R. A.; Meijers, F.; Menges, W.; Merritt, F. S.; Mes, H.; Meyer, N.; Michelini, A.; Mihara, S.; Mikenberg, G.; Miller, D. J.; Mohr, W.; Mori, T.; Mutter, A.; Nagai, K.; Nakamura, I.; Nanjo, H.; Neal, H. A.; O'Neale, S. W.; Oh, A.; Oreglia, M. J.; Orito, S.; Pahl, C.; Pásztor, G.; Pater, J. R.; Pilcher, J. E.; Pinfold, J.; Plane, D. E.; Pooth, O.; Przybycień, M.; Quadt, A.; Rabbertz, K.; Rembser, C.; Renkel, P.; Roney, J. M.; Rossi, A. M.; Rozen, Y.; Runge, K.; Sachs, K.; Saeki, T.; Sarkisyan, E. K. G.; Schaile, A. D.; Schaile, O.; Scharff-Hansen, P.; Schieck, J.; Schörner-Sadenius, T.; Schröder, M.; Schumacher, M.; Seuster, R.; Shears, T. G.; Shen, B. C.; Sherwood, P.; Skuja, A.; Smith, A. M.; Sobie, R.; Söldner-Rembold, S.; Spano, F.; Stahl, A.; Strom, D.; Ströhmer, R.; Tarem, S.; Tasevsky, M.; Teuscher, R.; Thomson, M. A.; Torrence, E.; Toya, D.; Trigger, I.; Trócsányi, Z.; Tsur, E.; Turner-Watson, M. F.; Ueda, I.; Ujvári, B.; Vollmer, C. F.; Vannerem, P.; Vértesi, R.; Verzocchi, M.; Voss, H.; Vossebeld, J.; Ward, C. P.; Ward, D. R.; Watkins, P. M.; Watson, A. T.; Watson, N. K.; Wells, P. S.; Wengler, T.; Wermes, N.; Wetterling, D.; Wilson, G. W.; Wilson, J. A.; Wolf, G.; Wyatt, T. R.; Yamashita, S.; Zer-Zion, D.; Zivkovic, L.

    2009-12-01

    Data collected around sqrt{s}=91 GeV by the OPAL experiment at the LEP e+e- collider are used to study the mechanism of baryon formation. As the signature, the fraction of Σ- hyperons whose baryon number is compensated by the production of a overline{Σ-},overline{Λ} or overline{Ξ-} antihyperon is determined. The method relies entirely on quantum number correlations of the baryons, and not rapidity correlations, making it more model independent than previous studies. Within the context of the JETSET implementation of the string hadronization model, the diquark baryon production model without the popcorn mechanism is strongly disfavored with a significance of 3.8 standard deviations including systematic uncertainties. It is shown that previous studies of the popcorn mechanism with Λ overline{Λ} and p\\uppi overline{p} correlations are not conclusive, if parameter uncertainties are considered.

  14. New production mechanism for keV sterile neutrino Dark Matter by decays of frozen-in scalars

    SciTech Connect

    Merle, Alexander; Niro, Viviana; Schmidt, Daniel E-mail: niro@ecm.ub.edu

    2014-03-01

    We propose a new production mechanism for keV sterile neutrino Dark Matter. In our setting, we assume the existence of a scalar singlet particle which never entered thermal equilibrium in the early Universe, since it only couples to the Standard Model fields by a really small Higgs portal interaction. For suitable values of this coupling, the scalar can undergo the so-called freeze-in process, and in this way be efficiently produced in the early Universe. These scalars can then decay into keV sterile neutrinos and produce the correct Dark Matter abundance. While similar settings in which the scalar does enter thermal equilibrium and then freezes out have been studied previously, the mechanism proposed here is new and represents a versatile extension of the known case. We perform a detailed numerical calculation of the DM production using a set of coupled Boltzmann equations, and we illustrate the successful regions in the parameter space. Our production mechanism notably can even work in models where active-sterile mixing is completely absent.

  15. Combinedatomic-nuclear decay

    NASA Astrophysics Data System (ADS)

    Dzyublik, A. Ya.

    2016-05-01

    We analyzed in details the combined decay of the atomic-nuclear state, which consists of the excited 3/2+ level of 63 153 Eu and K hole, formed in the K capture by 153Gd. This decay proceeds in two stages. First, the nucleus transfers its energy to 2 p electron, which flies into the continuum spectrum, and then returns into 1s hole, emitting γ quantum with the energy equal to the sum of energies of the nuclear and atomic transitions. We estimated the decay probability to be 2.2 × 10-13, that is much less than the recent experimental findings.

  16. Study of Decay Mechanisms in B-→Λc+p¯π- Decays and Observation of Low-Mass Structure in the Λc+p¯ System

    NASA Astrophysics Data System (ADS)

    Gabyshev, N.; Abe, K.; Abe, K.; Adachi, I.; Aihara, H.; Asano, Y.; Aulchenko, V.; Aushev, T.; Bakich, A. M.; Bitenc, U.; Bizjak, I.; Blyth, S.; Bondar, A.; Bozek, A.; Bračko, M.; Brodzicka, J.; Browder, T. E.; Chang, P.; Chao, Y.; Chen, A.; Chen, W. T.; Cheon, B. G.; Chistov, R.; Choi, S.-K.; Choi, Y.; Chuvikov, A.; Cole, S.; Dalseno, J.; Danilov, M.; Dash, M.; Drutskoy, A.; Eidelman, S.; Enari, Y.; Fratina, S.; Gershon, T.; Gokhroo, G.; Golob, B.; Gorišek, A.; Hara, T.; Hayashii, H.; Hazumi, M.; Hokuue, T.; Hoshi, Y.; Hou, S.; Hou, W.-S.; Hsiung, Y. B.; Iijima, T.; Imoto, A.; Inami, K.; Ishikawa, A.; Itoh, R.; Iwasaki, M.; Iwasaki, Y.; Kang, J. H.; Kang, J. S.; Kataoka, S. U.; Katayama, N.; Kawai, H.; Kawasaki, T.; Khan, H. R.; Kichimi, H.; Kim, H. J.; Kim, H. O.; Kim, S. K.; Kim, S. M.; Kinoshita, K.; Korpar, S.; Krokovny, P.; Kumar, S.; Kuo, C. C.; Kuzmin, A.; Kwon, Y.-J.; Lange, J. S.; Leder, G.; Lesiak, T.; Lin, S.-W.; Mandl, F.; Matsumoto, T.; Mikami, Y.; Mitaroff, W.; Miyake, H.; Miyata, H.; Mizuk, R.; Nagamine, T.; Nagasaka, Y.; Nakano, E.; Nakao, M.; Nakazawa, H.; Natkaniec, Z.; Nishida, S.; Nitoh, O.; Ogawa, S.; Ohshima, T.; Okabe, T.; Okuno, S.; Olsen, S. L.; Onuki, Y.; Ozaki, H.; Palka, H.; Park, C. W.; Park, H.; Parslow, N.; Peak, L. S.; Pestotnik, R.; Piilonen, L. E.; Rozanska, M.; Sagawa, H.; Sakai, Y.; Sato, N.; Schietinger, T.; Schneider, O.; Schwartz, A. J.; Senyo, K.; Seuster, R.; Sevior, M. E.; Shibuya, H.; Sidorov, V.; Singh, J. B.; Somov, A.; Stamen, R.; Stanič, S.; Starič, M.; Sumiyoshi, T.; Suzuki, S. Y.; Tajima, O.; Takasaki, F.; Tamai, K.; Tamura, N.; Tanaka, M.; Teramoto, Y.; Tian, X. C.; Tsuboyama, T.; Tsukamoto, T.; Uehara, S.; Uglov, T.; Ueno, K.; Uno, S.; Urquijo, P.; Varner, G.; Varvell, K. E.; Villa, S.; Wang, C. H.; Wang, M.-Z.; Xie, Q. L.; Yabsley, B. D.; Yamaguchi, A.; Yamamoto, H.; Yamashita, Y.; Yamauchi, M.; Yang, Heyoung; Zhang, C. C.; Zhang, J.; Zhang, L. M.; Zhang, Z. P.; Zhilich, V.; Žontar, D.

    2006-12-01

    Using a sample of 152×106 BB¯ pairs accumulated with the Belle detector at the KEKB e+e- collider, we study the decay mechanism of three-body charmed decay B-→Λc+p¯π-. The intermediate two-body decay B-→Σc(2455)0p¯ is observed for the first time with a branching fraction of (3.7±0.7±0.4±1.0)×10-5 and a statistical significance of 8.4σ. We also observe a low-mass enhancement in the (Λc+p¯) system, which can be parametrized as a Breit-Wigner function with a mass of (3.35-0.02+0.01±0.02)GeV/c2 and a width of (0.07-0.03+0.04±0.04)GeV/c2. We measure its branching fraction to be (3.9-0.7+0.8±0.4±1.0)×10-5 with a statistical significance of 6.2σ. The errors are statistical, systematic, and that of the Λc+→pK-π+ decay branching fraction.

  17. Prevention of weld-decay in austenitic stainless steel by using surface mechanical attrition treatment

    NASA Astrophysics Data System (ADS)

    Laleh, Majid; Kargar, Farzad; Rouhaghdam, Alireza Sabour

    2012-11-01

    Surface mechanical attrition treatment (SMAT) was applied to the samples of a type AISI 304 stainless steel in order to induce grain refinement as well as formation of twins. Transmission electron microscopy and X-ray diffraction analysis results showed that the average grain size at the surface of the SMATed sample was about 10 nm. The untreated and SMATed samples were then welded using a one-pass gas tungsten arc procedure. The heat-affected zone (HAZ) of the samples was examined by optical microscopy and corrosion tests. Results of the double loop electrochemical potentiokinetic reactivation tests showed that the degree of sensitization in the HAZ for the SMATed sample was very low as compared to that of the untreated one. The pre-SMATed sample was resistant to intergranular corrosion. This is mainly due to the formation of high density of twins which are not prone to carbide precipitation because of their regular and coherent atomic structure and extreme low grain boundary energy as compared with those of other grain boundaries.

  18. Effects of {alpha}-decay on mechanical properties of simulated nuclear waste glass

    SciTech Connect

    Inagaki, Y.; Furuya, H.; Ono, Y.; Idemitsu, K.; Banba, T.; Matsumoto, S.; Muraoka, S.

    1993-12-31

    A simulated nuclear waste glass was self-irradiated by doping with short-lived actinides of {sup 238}Pu and {sup 244}Cm. Changes in the hardness, the Young`s modulus and the fracture toughness, as a function of irradiation dose, were measured by use of identation techniques. The irradiated glass was annealed at temperatures from 573K to 723K for periods of up to 48 hours, and the recovery of these changes were measured as a function of annealing and time. It was observed that the hardness and the Young`s modulus decreased, while the fracture toughness increased exponentially with the cumulative dose. The maximum values of the relative changes in the hardness, the Young`s modulus and the fracture toughness were about -25%, -30% and +45%, respectively. The results of the annealing show that the hardness and the Young`s modulus were almost recovered to the original values at temperatures above 673 K within 10 hours, while the recovery of the fracture toughness was minimal in this region of temperature and time. The changes in the hardness and the Young`s modulus can be well explained by the model, in which the changes is proportional to the volume fraction of damaged zones, F, and the recovery of F is first order. On the other hand, the changes in the fracture toughness cannot be explained by the model, which suggests that the mechanism of the change in the fracture toughness is different from that in the hardness and the Young`s modulus.

  19. Genome, transcriptome, and secretome analysis of wood decay fungus postia placenta supports unique mechanisms of lignocellulose conversion

    SciTech Connect

    Martinez, Diego; Challacombe, Jean F; Misra, Monica; Xie, Gary; Brettin, Thomas; Morgenstern, Ingo; Hibbett, David; Schmoll, Monika; Kubicek, Christian P; Ferreira, Patricia; Ruiz - Duenase, Francisco J; Martinez, Angel T; Kersten, Phil; Hammel, Kenneth E; Vanden Wymelenberg, Amber; Gaskell, Jill; Lindquist, Erika; Sabati, Grzegorz; Bondurant, Sandra S; Larrondo, Luis F; Canessa, Paulo; Vicunna, Rafael; Yadavk, Jagiit; Doddapaneni, Harshavardhan; Subramaniank, Venkataramanan; Pisabarro, Antonio G; Lavin, Jose L; Oguiza, Jose A; Master, Emma; Henrissat, Bernard; Coutinho, Pedro M; Harris, Paul; Magnuson, Jon K; Baker, Scott; Bruno, Kenneth; Kenealy, William; Hoegger, Patrik J; Kues, Ursula; Ramaiva, Preethi; Lucas, Susan; Salamov, Asaf; Shapiro, Harris; Tuh, Hank; Chee, Christine L; Teter, Sarah; Yaver, Debbie; James, Tim; Mokrejs, Martin; Pospisek, Martin; Grigoriev, Igor; Rokhsar, Dan; Berka, Randy; Cullen, Dan

    2008-01-01

    Brown-rot fungi such as Postia placenta are common inhabitants of forest ecosystems and are also largely responsible for the destructive decay of wooden structures. Rapid depolymerization of cellulose is a distinguishing feature of brown-rot, but the biochemical mechanisms and underlying genetics are poorly understood. Systematic examination of the P. placenta genome, transcriptome and secretome revealed unique extracellular enzyme systems, including an unusual repertoire of extracellular glycoside hydrolases. Genes encoding exocellobiohydrolases and cellulose-binding domains, typical of cellulolytic microbes, are absent in this efficient cellulose-degrading fungus. When P. placenta was grown in medium containing cellulose as sole carbon source, transcripts corresponding to many hemicellulases and to a single putative {beta}-1-4 endoglucanase were expressed at high levels relative to glucose grown cultures. These transcript profiles were confirmed by direct identification of peptides by liquid chromatography-tandem mass spectrometry (LC{center_dot}MSIMS). Also upregulated during growth on cellulose medium were putative iron reductases, quinone reductase, and structurally divergent oxidases potentially involved in extracellular generation of Fe(II) and H202. These observations are consistent with a biodegradative role for Fenton chemistry in which Fe(II) and H202 react to form hydroxyl radicals, highly reactive oxidants capable of depolymerizing cellulose. The P. placenta genome resources provide unparalleled opportunities for investigating such unusual mechanisms of cellulose conversion. More broadly, the genome offers insight into the diversification of lignocellulose degrading mechanisms in fungi. Comparisons to the closely related white-rot fungus Phanerochaete chrysosporium support an evolutionary shift from white-rot to brown-rot during which the capacity for efficient depolymerization of lignin was lost.

  20. Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion

    SciTech Connect

    Martinez, Diego; Challacombe, Jean; Morgenstern, Ingo; Hibbett, David; Schmoll, Monika; Kubicek, Christian P.; Ferreira, Patricia; Ruiz-Duenas, Francisco; Martinez, Angel T.; Kersten, Phil; Hammel, Ken; Vanden Wymelenberg, Amber; Gaskell, Jill; Lindquist, Erika; Sabat, Gregorz; Splinter Bondurant, Sandra; Larrondo, Luis F.; Canessa, Paulo; Vicuna, Rafael; Yadev, Jagjit; Doddapaneni, Harshavardhan; Subramanian, Venkataramanan; Pisabarro, Antonio; Lavin, Jose L.; Oguiza, Jose A.; Master, Emma; Henrissat, Bernard; Coutinho, Pedro M.; Harris, Paul; Magnuson, Jon K.; Baker, Scott E.; Bruno, Kenneth S.; Kenealy, William; Hoegger, Patrik; Kues, Ursula; Ramaiya, Preethi; Lucas, Susan; Salamov, Asaf; Shapiro, Harris; Tu, Hank; Chee, Christine L.; Misra, Monica; Xie, Gary; Teter, Sarah; Yaver, Debbie; James, Tim; Mokrejs, Martin; Pospisek, Martin; Grigoriev, Igor V.; Brettin, T.; Rokhsar, Daniel S.; Berka, Randy; Cullen, Dan

    2009-02-10

    Brown-rot fungi such as Postia placenta are common inhabitants of forest ecosystems and are also largely responsible for the destructive decay of wooden structures. Rapid depolymerization of cellulose is a distinguishing feature of brown-rot, but the biochemical mechanisms and underlying genetics are poorly understood. Systematic examination of the P. placenta genome, transcriptome, and secretome revealed unique extracellular enzyme systems, including an unusual repertoire of extracellular glycoside hydrolases. Genes encoding exocellobiohydrolases and cellulose-binding domains, typical of cellulolytic microbes, are absent in this efficient cellulose-degrading fungus. When P. placenta was grown in media containing cellulose as sole carbon source, transcripts corresponding to many hemicellulases and to a single putative β-1-4 endoglucanase were expressed at high levels relative to glucose grown cultures. These transcript profiles were confirmed by direct identification of peptides by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Also upregulated under cellulolytic culture conditions were putative iron reductases, quinone reductase, and structurally divergent oxidases potentially involved in extracellular generation of Fe(II) and H2O2. These observations are consistent with a biodegradative role for Fenton chemistry in which Fe(II) and H2O2 react to form hydroxyl radicals, highly reactive oxidants capable of depolymerizing cellulose. The P. placenta genome resources provide unparalleled opportunities for investigating such unusual mechanisms of cellulose conversion. More broadly, the genome offers insight into the diversification of lignocellulose degrading mechanisms in fungi. In particular, comparisons between P. placenta and the closely related white-rot fungus, Phanerochaete chrysosporium support an evolutionary shift from white-rot to brown-rot during which efficient depolymerization of lignin was lost.

  1. Hydrogen peroxide formation and decay in iron-rich geothermal waters: the relative roles of abiotic and biotic mechanisms

    PubMed

    Wilson; Hinman; Sheridan

    2000-06-01

    .0007 mol H2O2 per mol photon at 300 nm and < 0.0005 H2O2 per mol photon at 340 nm; [Scully, N. M., D. R. S. Lean, D. J. McQueen and W. J. Cooper (1996) Limnol. Oceanogr. 41, 540-548]). In natural solar source experiments, H2O2 formation was greater in experiments with UVA and photosynthetically active radiation (PAR; 400-700 nm) than with PAR alone or with UVB, UVA and PAR. However, H2O2 capacity (nM H2O2 W-1 h-1 m2) was greatest with UVB radiation and lowest with PAR radiation. Source regions could not be studied separately. Dark decay of H2O2 occurred via two mechanisms. The main mechanism responsible for H2O2 decay involved particulate matter (probably microorganisms), whereas a secondary mechanism involved soluble matter (i.e. DOC, metal ions and other dissolved species involved in Fenton reactions). PMID:10857364

  2. Decay of metastable topological defects

    SciTech Connect

    Preskill, J. ); Vilenkin, A. Lyman Laboratory of Physics, Harvard University, Cambridge, Massachusetts 02138 )

    1993-03-15

    We systematically analyze the decay of metastable topological defects that arise from the spontaneous breakdown of gauge or global symmetries. Quantum-mechanical tunneling rates are estimated for a variety of decay processes. The decay rate for a global string, vortex, domain wall, or kink is typically suppressed compared to the decay rate for its gauged counterpart. We also discuss the decay of global texture, and of semilocal and electroweak strings.

  3. E6 Gamma Decay

    SciTech Connect

    Brown, B. Alex; Rae, W. D. M.

    2011-05-06

    Rare electric hexacontatetrapole (E6) transitions are studied in the full (f{sub 7/2},f{sub 5/2},p{sub 3/2},p{sub 1/2}) shell-model basis. Comparison of theory to the results from the gamma decay in {sup 53}Fe and from inelastic electron scattering on {sup 52}Cr provides unique and interesting tests of the valence wavefunctions, the models used for energy density functionals and into the origin of effective charge.

  4. Managing Linguistic Data Summaries in Advanced P2P Applications

    NASA Astrophysics Data System (ADS)

    Hayek, Rabab; Raschia, Guillaume; Valduriez, Patrick; Mouaddib, Noureddine

    As the amount of stored data increases, data localization techniques become no longer sufficient in P2P systems. A practical approach is to rely on compact database summaries rather than raw database records, whose access is costly in large P2P systems. In this chapter, we describe a solution for managing linguistic data summaries in advanced P2P applications which are dealing with semantically rich data. The produced summaries are synthetic, multidimensional views over relational tables. The novelty of this proposal relies on the double summary exploitation in distributed P2P systems. First, as semantic indexes, they support locating relevant nodes based on their data descriptions. Second, due to their intelligibility, these summaries can be directly queried and thus approximately answer a query without the need for exploring original data. The proposed solution consists first in defining a summary model for hierarchical P2P systems. Second, appropriate algorithms for summary creation and maintenance are presented. A query processing mechanism, which relies on summary querying, is then proposed to demonstrate the benefits that might be obtained from summary exploitation.

  5. Decay Mechanism of NO3(•) Radical in Highly Concentrated Nitrate and Nitric Acidic Solutions in the Absence and Presence of Hydrazine.

    PubMed

    Garaix, Guillaume; Horne, Gregory P; Venault, Laurent; Moisy, Philippe; Pimblott, Simon M; Marignier, Jean Louis; Mostafavi, Mehran

    2016-06-01

    The decay mechanism of NO3(•) has been determined through a combination of experiment and calculation for 7 mol dm(-3) solutions of deaerated aqueous LiNO3 and HNO3, in the absence and presence of hydrazine (N2H4, N2H5(+), and N2H6(2+)). In the absence of hydrazine, the predominant NO3(•) decay pathways are strongly dependent upon the pH of the solution. For neat, neutral pH LiNO3 solutions (7 mol dm(-3)), NO3(•) produced by the pulse is fully consumed within 160 μs by OH(•) (37%), H2O (29%), NO2(-) (17%), and NO2 (17%). For acidic HNO3 solutions (7 mol dm(-3)), radiolytically produced NO3(•) is predominantly consumed within 1 ms by HNO2 (15%) and NO2 (80%). Intervening formulations exhibit the mechanistic transition from neat LiNO3 to neat HNO3. In highly acidic nitric acid solution, hydrazine exists mainly as N2H5(+) and N2H6(2+), both of which rapidly consume NO3(•) in addition to other decay mechanisms, with rate constants of 2.9 (±0.9) × 10(7) and 1.3 (±0.3) × 10(6) dm(3) mol(-1) s(-1), respectively. PMID:27171587

  6. DNA Compaction by Yeast Mitochondrial Protein ABF2p

    SciTech Connect

    Friddle, R W; Klare, J E; Noy, A; Corzett, M; Balhorn, R; Baskin, R J; Martin, S S; Baldwin, E P

    2003-05-09

    We used high resolution Atomic Force Microscopy (AFM) to image compaction of linear and circular DNA by the yeast mitochondrial protein ABF2p , which plays a major role in maintaining mitochondrial DNA. AFM images show that protein binding induces drastic bends in the DNA backbone for both linear and circular DNA. At high concentration of ABF2p DNA collapses into a tight globular structure. We quantified the compaction of linear DNA by measuring the end-to-end distance of the DNA molecule at increasing concentrations of ABF2p. We also derived a polymer statistical mechanics model that gives quantitative description of compaction observed in our experiments. This model shows that a number of sharp bends in the DNA backbone is often sufficient to cause DNA compaction. Comparison of our model with the experimental data showed excellent quantitative correlation and allowed us to determine binding characteristics for ABF2. Our studies indicate that ABF2 compacts DNA through a novel mechanism that involves bending of DNA backbone. We discuss the implications of such a mechanism for mitochondrial DNA maintenance.

  7. Studies of mechanisms of decay and recovery in organic dye-doped polymers using spatially resolved white light interferometry

    NASA Astrophysics Data System (ADS)

    Anderson, Benjamin; Bernhardt, Elizabeth; Kuzyk, Mark

    2012-10-01

    Several organic dyes have been shown to self heal when doped in a polymer matrix. Most measurements to date use optical absorbance, amplified spontaneous emission, or digital imaging as a probe. Each method determines a subset of the relevant parameters. We have constructed a white light interferometric microscope, which measures the absorption spectrum and change in refractive index during decay and recovery simultaneously at multiple points in the material. We report on preliminary measurements and results concerning the microscopes spatial resolution.

  8. General decay rates for the wave equation with mixed-type damping mechanisms on unbounded domain with finite measure

    NASA Astrophysics Data System (ADS)

    Dias Silva, Flávio R.; Nascimento, Flávio A. F.; Rodrigues, José H.

    2015-12-01

    This paper is concerned with the study of the uniform decay rates of the energy associated with the wave equation subject to a locally distributed viscoelastic dissipation and a nonlinear frictional damping u_{tt}- Δ u+ int_0^t g(t-s)div[a(x)nabla u(s)] ds + b(x) f(u_t)=0 quad on quad Ω×]0,infty[, where {Ωsubset{R}^n, n≥ 2} is an unbounded open set with finite measure and unbounded smooth boundary {partialΩ = Γ}. Supposing that the localization functions satisfy the "competitive" assumption {a(x)+b(x)≥δ>0} for all {xin Ω} and the relaxation function g satisfies certain nonlinear differential inequalities introduced by Lasiecka et al. (J Math Phys 54(3):031504, 2013), we extend to our considered domain the prior results of Cavalcanti and Oquendo (SIAM J Control Optim 42(4):1310-1324, 2003). In addition, while in Cavalcanti and Oquendo (2003) the authors just consider exponential and polynomial decay rate estimates, in the present article general decay rate estimates are obtained.

  9. Chelating efficiency and thermal, mechanical and decay resistance performances of chitosan copper complex in wood-polymer composites.

    PubMed

    Lu, John Z; Duan, Xinfang; Wu, Qinglin; Lian, Kun

    2008-09-01

    Wood-polymer composites (WPC) have been extensively used for building products, outdoor decking, automotive, packaging materials, and other applications. WPC is subject to fungal and termite attacks due to wood components enveloped in the thermoplastic matrix. Much effort has been made to improve decay resistance of WPC using zinc borate and other chemicals. In this study, chitosan copper complex (CCC) compounds were used as a potential preservative for wood-HDPE composites. CCC was formulated by reacting chitosan with copper salts under controlled conditions. Inductively coupled plasma (ICP) analytical results indicated that chitosan had high chelating efficiency with copper cations. CCC-treated wood-HDPE composites had a thermal behavior similar to untreated and zinc borate-treated wood-HDPE composites. Incorporation of CCC in wood-HDPE composites did not significantly influence board density of the resultant composites, but had a negative effect on tensile strength at high CCC concentration. In comparison with solid wood and the untreated wood-HDPE composites, 3% CCC-treated wood-HDPE composites significantly improved the decay resistance against white rot fungus Trametes versicolor and brown rot fungus Gloeophyllum trabeum. Especially, CCC-treated wood-HDPE composites were more effectively against the brown rot than the untreated and chitosan-treated wood-HDPE composites. Moreover, CCC-treated wood-HDPE composites performed well as zinc borate-treated wood-HDPE composites on fungal decay resistance. Accordingly, CCC can be effectively used as a preservative for WPC. PMID:18248812

  10. Kinetics of the Reactions of F((sup 2)P) and Cl((sup 2)P) with HNO3

    NASA Technical Reports Server (NTRS)

    Wine, P. H.; Wells, J. R.; Nicovich, J. M.

    1997-01-01

    The kinetics of the reactions of HNO3 with fluorine (k(sub 1)) and Chlorine (k(sub 2)) atoms have been studied by using a time-resolved long-path laser absorption technique to monitor the appearance of product NO3 radicals following 351-nm pulsed laser photolysis of X2/HNO3/He mixtures (X = F,Cl). Absolute rate coefficients for the F((sup 2)P) + HNO reaction have been determined over the temperature range 260-373 K. Between 260 and 320 K, the data are adequately represented by the Arrhenius expression k(sub 1)(T) = (6.0 +/- 2.6) x 10(exp -12) exp[(40 +/- 120)/T]cu cm/(molecule.s). Between 335 and 373 K, the rate coefficient is found to be (2.0 +/- 0.3) x 10(exp -11)cu cm/(molecule.s) independent of temperature. The observed temperature dependence suggests that reaction proceeds via competing direct abstraction and complex pathways. No NO3 production was observed in the experiments with X equals Cl, thus establishing that k(sub 2)(298 K) is less than 2 x 10(exp -16) cu cm/(molecule.s). The Cl((sup 2)P) + HNO reaction was also investigated by using a pulsed laser photolysis-resonance fluorescence technique to monitor the decay of Cl((sup 2)P). Upper limit values for k(sub 2) obtained from these experiments, in units of 10(exp -16)cu cm/(molecule.s), are 13 at 298 K and 10 at 400 K.

  11. Electronic states of BP, BP +, BP -, B 2P 2, B2P2- and B2P2+

    NASA Astrophysics Data System (ADS)

    Linguerri, Roberto; Komiha, Najia; Oswald, Rainer; Mitrushchenkov, Alexander; Rosmus, Pavel

    2008-05-01

    Using augmented sextuple zeta basis sets and internally contracted multireference configuration interaction (MRCI) wavefunctions, potential energy, electric dipole and transition moments have been computed for the X 3Π, a 1Σ +, b 1Π and A 3Σ - states of BP, X 2Σ + and A 2Π states of BP - and X 4Σ - and A 4Π states of BP +. From these data spectroscopic constants, radiative transition probabilities and photoelectron spectra of BP - and BP have been evaluated. The non-vanishing spin-orbit coupling elements between the four low lying triplet and singlet states of the neutral BP have also been calculated from MRCI wavefunctions. The treatment of the corresponding perturbations in the manifold of dense rovibrational states in the three lowest states would require a precise knowledge of the electronic excitation energies. Our best singlet-triplet separations (X-a) are calculated to be 2412 cm -1 (MRCI) and 2482 cm -1 (restricted coupled cluster with perturbative triples (RCCSD(T))) with an estimated error bound of about ±200 cm -1. All three states have long radiative lifetimes with cascading among the rovibrational levels of different states. The ionization energy IE e of BP is calculated to be 9.22 eV (MRCI) and 9.48 eV (RCCSD(T)), the electron affinity EA e 2.51 eV (MRCI) and 2.74 eV (RCCSD(T)). The photoelectron spectra of BP and BP - have been obtained from the Franck-Condon factors of the MRCI potentials. For the UV spectroscopy the dipole allowed radiative transition probabilities are given for A 3Σ - ↔ X 3Π, b 1Π ↔ a 1Σ + of BP, A 2Π ↔ X 2Σ + of BP - and A 4Π ↔ X 4Σ - of BP +. The ionization energy IE e of B 2P 2 of 8.71 eV and the electron affinity EA e of 2.34 eV have been calculated by the RCCSD(T)/aVQZ approach. Also the harmonic vibrational wavenumbers for the electronic ground states of the ions B2P2+ and B2P2- are given.

  12. Multiple Decay Mechanisms and 2D-UV Spectroscopic Fingerprints of Singlet Excited Solvated Adenine-Uracil Monophosphate.

    PubMed

    Li, Quansong; Giussani, Angelo; Segarra-Martí, Javier; Nenov, Artur; Rivalta, Ivan; Voityuk, Alexander A; Mukamel, Shaul; Roca-Sanjuán, Daniel; Garavelli, Marco; Blancafort, Lluís

    2016-05-23

    The decay channels of singlet excited adenine uracil monophosphate (ApU) in water are studied with CASPT2//CASSCF:MM potential energy calculations and simulation of the 2D-UV spectroscopic fingerprints with the aim of elucidating the role of the different electronic states of the stacked conformer in the excited state dynamics. The adenine (1) La state can decay without a barrier to a conical intersection with the ground state. In contrast, the adenine (1) Lb and uracil S(U) states have minima that are separated from the intersections by sizeable barriers. Depending on the backbone conformation, the CT state can undergo inter-base hydrogen transfer and decay to the ground state through a conical intersection, or it can yield a long-lived minimum stabilized by a hydrogen bond between the two ribose rings. This suggests that the (1) Lb , S(U) and CT states of the stacked conformer may all contribute to the experimental lifetimes of 18 and 240 ps. We have also simulated the time evolution of the 2D-UV spectra and provide the specific fingerprint of each species in a recommended probe window between 25 000 and 38 000 cm(-1) in which decongested, clearly distinguishable spectra can be obtained. This is expected to allow the mechanistic scenarios to be discerned in the near future with the help of the corresponding experiments. Our results reveal the complexity of the photophysics of the relatively small ApU system, and the potential of 2D-UV spectroscopy to disentangle the photophysics of multichromophoric systems. PMID:27113273

  13. Mechanisms of the isospin-breaking decay f1(1285 )→f0(980 )π0→π+π-π0

    NASA Astrophysics Data System (ADS)

    Achasov, N. N.; Kozhevnikov, A. A.; Shestakov, G. N.

    2016-06-01

    Estimated are the contributions of the following mechanisms responsible for the decay f1(1285 )→f0(980 )π0→π+π-π0 : (1) the contribution of the a00(980 )-f0(980 ) mixing, f1(1285 )→a0(980 )π0→(K+K-+K0K¯ 0)π0→f0(980 )π0→π+π-π0 , (2) the contribution of the transition f1(1285 )→(K+K-+K0K¯ 0)π0→f0(980 )π0→π+π-π0 , arising due to the pointlike decay f1(1285 )→K K ¯ π0 , (3) the contribution of the transition f1(1285 )→(K*K ¯ +K¯ *K )→(K+K-+K0K¯ 0)π0→f0(980 )π0→π+π-π0 , where K*=K*(892 ) , and (4) the contribution of the transition f1(1285 )→(K0*K ¯ +K¯0 *K )→(K+K-+K0K¯ 0)π0→f0(980 )→π+π-π0 , where K0*=K0*(800 ) (or κ ) and K0*(1430 ). These mechanisms break the conservation of the isospin due to the nonzero mass difference of the K+ and K0 mesons. They result in the appearance of the narrow resonance structure in the π+π- mass spectrum in the region of the K K ¯ thresholds, with the width ≈2 mK0-2 mK+≈8 MeV . The observation of such a structure in experiment is the direct indication on the K K ¯ loop mechanism of the breaking of the isotopic invariance. We point out that existing data should be more precise, and it is difficult to explain them using the single specific mechanism from those listed above. Taking the decay f1(1285 )→f0(980 )π0→π+π-π0 as the example, we discuss the general approach to the description of the K K ¯ loop mechanism of the breaking of isotopic invariance.

  14. Hypernuclear Weak Decays

    NASA Astrophysics Data System (ADS)

    Itonaga, K.; Motoba, T.

    The recent theoretical studies of Lambda-hypernuclear weak decaysof the nonmesonic and pi-mesonic ones are developed with the aim to disclose the link between the experimental decay observables and the underlying basic weak decay interactions and the weak decay mechanisms. The expressions of the nonmesonic decay rates Gamma_{nm} and the decay asymmetry parameter alpha_1 of protons from the polarized hypernuclei are presented in the shell model framework. We then introduce the meson theoretical Lambda N -> NN interactions which include the one-meson exchanges, the correlated-2pi exchanges, and the chiral-pair-meson exchanges. The features of meson exchange potentials and their roles on the nonmesonic decays are discussed. With the adoption of the pi + 2pi/rho + 2pi/sigma + omega + K + rhopi/a_1 + sigmapi/a_1 exchange potentials, we have carried out the systematic calculations of the nonmesonic decay observables for light-to-heavy hypernuclei. The present model can account for the available experimental data of the decay rates, Gamma_n/Gamma_p ratios, and the intrinsic asymmetry parameters alpha_Lambda (alpha_Lambda is related to alpha_1) of emitted protons well and consistently within the error bars. The hypernuclear lifetimes are evaluated by converting the total weak decay rates Gamma_{tot} = Gamma_pi + Gamma_{nm} to tau, which exhibit saturation property for the hypernuclear mass A ≥ 30 and agree grossly well with experimental data for the mass range from light to heavy hypernuclei except for the very light ones. Future extensions of the model and the remaining problems are also mentioned. The pi-mesonic weak processes are briefly surveyed, and the calculations and predictions are compared and confirmed by the recent high precision FINUDA pi-mesonic decay data. This shows that the theoretical basis seems to be firmly grounded.

  15. Modulation of K2P2.1 and K2P10.1 K+ channel sensitivity to carvedilol by alternative mRNA translation initiation

    PubMed Central

    Kisselbach, J; Seyler, C; Schweizer, P A; Gerstberger, R; Becker, R; Katus, H A; Thomas, D

    2014-01-01

    Background and Purpose The β-receptor antagonist carvedilol blocks a range of ion channels. K2P2.1 (TREK1) and K2P10.1 (TREK2) channels are expressed in the heart and regulated by alternative translation initiation (ATI) of their mRNA, producing functionally distinct channel variants. The first objective was to investigate acute effects of carvedilol on human K2P2.1 and K2P10.1 channels. Second, we sought to study ATI-dependent modulation of K2P K+ current sensitivity to carvedilol. Experimental Approach Using standard electrophysiological techniques, we recorded currents from wild-type and mutant K2P2.1 and K2P10.1 channels in Xenopus oocytes and HEK 293 cells. Key Results Carvedilol concentration-dependently inhibited K2P2.1 channels (IC50,oocytes = 20.3 μM; IC50,HEK = 1.6 μM) and this inhibition was frequency-independent. When K2P2.1 isoforms generated by ATI were studied separately in oocytes, the IC50 value for carvedilol inhibition of full-length channels (16.5 μM) was almost 5-fold less than that for the truncated channel variant (IC50 = 79.0 μM). Similarly, the related K2P10.1 channels were blocked by carvedilol (IC50,oocytes = 24.0 μM; IC50,HEK = 7.6 μM) and subject to ATI-dependent modulation of drug sensitivity. Conclusions and Implications Carvedilol targets K2P2.1 and K2P10.1 K+ channels. This previously unrecognized mechanism supports a general role of cardiac K2P channels as antiarrhythmic drug targets. Furthermore, the work reveals that the sensitivity of the cardiac ion channels K2P2.1 and K2P10.1 to block was modulated by alternative mRNA translation initiation. PMID:25168769

  16. Root proliferation in decaying roots and old root channels: A nutrient conservation mechanism in oligotrophic mangrove forests?

    USGS Publications Warehouse

    McKee, K.L.

    2001-01-01

    1. In oligotrophic habitats, proliferation of roots in nutrient-rich microsites may contribute to overall nutrient conservation by plants. Peat-based soils on mangrove islands in Belize are characterized by the presence of decaying roots and numerous old root channels (0.1-3.5 cm diameter) that become filled with living and highly branched roots of Rhizophora mangle and Avicennia germinans. The objectives of this study were to quantify the proliferation of roots in these microsites and to determine what causes this response. 2. Channels formed by the refractory remains of mangrove roots accounted for only 1-2% of total soil volume, but the proportion of roots found within channels varied from 9 to 24% of total live mass. Successive generations of roots growing inside increasingly smaller root channels were also found. 3. When artificial channels constructed of PVC pipe were buried in the peat for 2 years, those filled with nutrient-rich organic matter had six times more roots than empty or sand-filled channels, indicating a response to greater nutrient availability rather than to greater space or less impedance to root growth. 4. Root proliferation inside decaying roots may improve recovery of nutrients released from decomposing tissues before they can be leached or immobilized in this intertidal environment. Greatest root proliferation in channels occurred in interior forest zones characterized by greater soil waterlogging, which suggests that this may be a strategy for nutrient capture that minimizes oxygen losses from the whole root system. 5. Improved efficiency of nutrient acquisition at the individual plant level has implications for nutrient economy at the ecosystem level and may explain, in part, how mangroves persist and grow in nutrient-poor environments.

  17. Tooth Decay

    MedlinePlus

    ... decay starts in the outer layer, called the enamel. Without a filling, the decay can get deep into the tooth and its nerves and cause a toothache or abscess. To help prevent cavities Brush your teeth every day with a fluoride toothpaste Clean between ...

  18. Fuzzy-rule-based Adaptive Resource Control for Information Sharing in P2P Networks

    NASA Astrophysics Data System (ADS)

    Wu, Zhengping; Wu, Hao

    With more and more peer-to-peer (P2P) technologies available for online collaboration and information sharing, people can launch more and more collaborative work in online social networks with friends, colleagues, and even strangers. Without face-to-face interactions, the question of who can be trusted and then share information with becomes a big concern of a user in these online social networks. This paper introduces an adaptive control service using fuzzy logic in preference definition for P2P information sharing control, and designs a novel decision-making mechanism using formal fuzzy rules and reasoning mechanisms adjusting P2P information sharing status following individual users' preferences. Applications of this adaptive control service into different information sharing environments show that this service can provide a convenient and accurate P2P information sharing control for individual users in P2P networks.

  19. Security Issues for P2P-Based Voice- and Video-Streaming Applications

    NASA Astrophysics Data System (ADS)

    Seedorf, Jan

    P2P computing offers a new interesting field for security researchers. Being highly distributed and lacking centralised, trusted entities for bootstrapping security mechanisms, these systems demand novel approaches for decentralised security solutions.

  20. Radiative lifetimes of the 2s2p2(4P) metastable levels of N III

    NASA Technical Reports Server (NTRS)

    Fang, Z.; Kwong, Victor H. S.; Parkinson, W. H.

    1993-01-01

    The radiative decay rates of N III 175 nm intersystem lines were measured in the laboratory by recording the time dependence of photon intensities emitted as the 2s2p2(4P) metastable term of N(2+) ions decay to the 2s22p(2P0) ground term. A cylindrical radio frequency ion trap was used to store the electron impact-produced N(2+) ions. The radiative decay signals were analyzed by multiexponential least-squares fits to the data. The measured radiative decay rates to the ground term are 1019(+/- 64)/s for 4P sub 1/2, 74.5(+/- 5.4)/s for 4P sub 3/2, and 308( +/- 22)/s for 4P sub 5/2. Comparisons of the measured values with theoretical values are presented.

  1. Capacity Decay Mechanism of Microporous Separator-Based All-Vanadium Redox Flow Batteries and its Recovery

    SciTech Connect

    Li, Bin; Luo, Qingtao; Wei, Xiaoliang; Nie, Zimin; Thomsen, Edwin; Chen, Baowei; Sprenkle, Vincent; Wang, Wei

    2013-10-29

    For all vanadium redox flow batteries (VRBs) with porous separators as membranes, convection effect is found to play a dominant role in the capacity decay of the cells over cycling by investigating the relationship between electrical performances and electrolyte compositions at both positive and negative sides. Although the concentration of total vanadium ions hardly changes at both sides over cycling, the net transfer of solutions from one side to another and thus asymmetrical valance of vanadium ions at both sides lead to the capacity fading and lower energy efficiency, which is confirmed to result from the hydraulic pressure differential at both sides of separators. In this paper, the hydraulic pressures of solutions at both sides can be in-situ monitored, and regulated by varying the gas pressures in electrolyte tanks. It is found that the capacity can be stabilized and the net transfer of solutions can be prevented by slightly tailoring the hydraulic pressure differential at both sides of separators, which, however, doesn’t work for Nafion membranes, suggesting the negligible convection factor in flow cells using Nafion membranes. Therefore, the possibility of porous separators allows long-term running for VRBs without capacity loss, highlighting a new pathway to develop membranes used in VRBs.

  2. Therapeutic targeting of two-pore-domain potassium (K(2P)) channels in the cardiovascular system.

    PubMed

    Wiedmann, Felix; Schmidt, Constanze; Lugenbiel, Patrick; Staudacher, Ingo; Rahm, Ann-Kathrin; Seyler, Claudia; Schweizer, Patrick A; Katus, Hugo A; Thomas, Dierk

    2016-05-01

    The improvement of treatment strategies in cardiovascular medicine is an ongoing process that requires constant optimization. The ability of a therapeutic intervention to prevent cardiovascular pathology largely depends on its capacity to suppress the underlying mechanisms. Attenuation or reversal of disease-specific pathways has emerged as a promising paradigm, providing a mechanistic rationale for patient-tailored therapy. Two-pore-domain K(+) (K(2P)) channels conduct outward K(+) currents that stabilize the resting membrane potential and facilitate action potential repolarization. K(2P) expression in the cardiovascular system and polymodal K2P current regulation suggest functional significance and potential therapeutic roles of the channels. Recent work has focused primarily on K(2P)1.1 [tandem of pore domains in a weak inwardly rectifying K(+) channel (TWIK)-1], K(2P)2.1 [TWIK-related K(+) channel (TREK)-1], and K(2P)3.1 [TWIK-related acid-sensitive K(+) channel (TASK)-1] channels and their role in heart and vessels. K(2P) currents have been implicated in atrial and ventricular arrhythmogenesis and in setting the vascular tone. Furthermore, the association of genetic alterations in K(2P)3.1 channels with atrial fibrillation, cardiac conduction disorders and pulmonary arterial hypertension demonstrates the relevance of the channels in cardiovascular disease. The function, regulation and clinical significance of cardiovascular K(2P) channels are summarized in the present review, and therapeutic options are emphasized. PMID:26993052

  3. Eukaryotic Initiation Factor 4G Suppresses Nonsense-Mediated mRNA Decay by Two Genetically Separable Mechanisms

    PubMed Central

    Joncourt, Raphael; Eberle, Andrea B.; Rufener, Simone C.; Mühlemann, Oliver

    2014-01-01

    Nonsense-mediated mRNA decay (NMD), which is best known for degrading mRNAs with premature termination codons (PTCs), is thought to be triggered by aberrant translation termination at stop codons located in an environment of the mRNP that is devoid of signals necessary for proper termination. In mammals, the cytoplasmic poly(A)-binding protein 1 (PABPC1) has been reported to promote correct termination and therewith antagonize NMD by interacting with the eukaryotic release factors 1 (eRF1) and 3 (eRF3). Using tethering assays in which proteins of interest are recruited as MS2 fusions to a NMD reporter transcript, we show that the three N-terminal RNA recognition motifs (RRMs) of PABPC1 are sufficient to antagonize NMD, while the eRF3-interacting C-terminal domain is dispensable. The RRM1-3 portion of PABPC1 interacts with eukaryotic initiation factor 4G (eIF4G) and tethering of eIF4G to the NMD reporter also suppresses NMD. We identified the interactions of the eIF4G N-terminus with PABPC1 and the eIF4G core domain with eIF3 as two genetically separable features that independently enable tethered eIF4G to inhibit NMD. Collectively, our results reveal a function of PABPC1, eIF4G and eIF3 in translation termination and NMD suppression, and they provide additional evidence for a tight coupling between translation termination and initiation. PMID:25148142

  4. Pseudogene CYP4Z2P 3′UTR promotes angiogenesis in breast cancer

    SciTech Connect

    Zheng, Lufeng; Li, Xiaoman; Gu, Yi; Ma, Yihua; Xi, Tao

    2014-10-24

    Highlights: • A new critical role of pseudogene CYP4Z2P 3′UTR in breast cancer is proposed. • We examine the level of pseudogene CYP4Z2P 3′UTR in breast cancer tissues. • The functions of CYP4Z2P 3′UTR and mechanism were studied. • The mechanism provides new insights for the breast cancer progression. - Abstract: Pseudogenes have long been marked as “false” genes, which are similar with real genes but have no apparent function. The 3′UTR is well-known to regulate gene expression post-transcriptionally. Our recent evidence, however, indicates novel functional roles of pseudogene CYP4Z2P 3′UTR (Z2P-UTR). We found that ectopic expression of Z2P-UTR in breast cancer cells significantly increased the expression of VEGF-A without affecting cell proliferation in vitro. Meanwhile, conditioned medium (CM) from Z2P-UTR overexpression cells enhanced proliferation, migration and tube formation of HUVEC, and promoted angiogenesis in ex vivo models. Also, CM increased the expression of VEGFR2 in HUVEC. Our data suggest that Z2P-UTR can promote breast cancer angiogenesis partly via paracrine pathway of VEGF-A/VEGFR2.

  5. Phosphatidylserine stimulation of Drs2p·Cdc50p lipid translocase dephosphorylation is controlled by phosphatidylinositol-4-phosphate.

    PubMed

    Jacquot, Aurore; Montigny, Cédric; Hennrich, Hanka; Barry, Raphaëlle; le Maire, Marc; Jaxel, Christine; Holthuis, Joost; Champeil, Philippe; Lenoir, Guillaume

    2012-04-13

    Here, Drs2p, a yeast lipid translocase that belongs to the family of P(4)-type ATPases, was overexpressed in the yeast Saccharomyces cerevisiae together with Cdc50p, its glycosylated partner, as a result of the design of a novel co-expression vector. The resulting high yield allowed us, using crude membranes or detergent-solubilized membranes, to measure the formation from [γ-(32)P]ATP of a (32)P-labeled transient phosphoenzyme at the catalytic site of Drs2p. Formation of this phosphoenzyme could be detected only if Cdc50p was co-expressed with Drs2p but was not dependent on full glycosylation of Cdc50p. It was inhibited by orthovanadate and fluoride compounds. In crude membranes, the phosphoenzyme formed at steady state at 4 °C displayed ADP-insensitive but temperature-sensitive decay. Solubilizing concentrations of dodecyl maltoside left this decay rate almost unaltered, whereas several other detergents accelerated it. Unexpectedly, the dephosphorylation rate for the solubilized Drs2p·Cdc50p complex was inhibited by the addition of phosphatidylserine. Phosphatidylserine exerted its anticipated accelerating effect on the dephosphorylation of Drs2p·Cdc50p complex only in the additional presence of phosphatidylinositol-4-phosphate. These results explain why phosphatidylinositol-4-phosphate tightly controls Drs2p-catalyzed lipid transport and establish the functional relevance of the Drs2p·Cdc50p complex overexpressed here. PMID:22351780

  6. An anti-attack model based on complex network theory in P2P networks

    NASA Astrophysics Data System (ADS)

    Peng, Hao; Lu, Songnian; Zhao, Dandan; Zhang, Aixin; Li, Jianhua

    2012-04-01

    Complex network theory is a useful way to study many real systems. In this paper, an anti-attack model based on complex network theory is introduced. The mechanism of this model is based on a dynamic compensation process and a reverse percolation process in P2P networks. The main purpose of the paper is: (i) a dynamic compensation process can turn an attacked P2P network into a power-law (PL) network with exponential cutoff; (ii) a local healing process can restore the maximum degree of peers in an attacked P2P network to a normal level; (iii) a restoring process based on reverse percolation theory connects the fragmentary peers of an attacked P2P network together into a giant connected component. In this way, the model based on complex network theory can be effectively utilized for anti-attack and protection purposes in P2P networks.

  7. Counterflow driven by swirl decay

    NASA Astrophysics Data System (ADS)

    Shtern, Vladimir N.; Borissov, Anatoli A.

    2010-06-01

    The global meridional circulation of a viscous fluid, caused by swirl decay in a cylindrical container, is studied. To this end, a new solution to the Navier-Stokes equations is obtained, and simple experiments are performed to verify the predictions of the theory. The swirl decay mechanism explains elongated counterflows in hydrocyclones and vortex tubes sometimes extending over a hundred diameters.

  8. Use of microphysical relationships to discern growth/decay mechanisms of cloud droplets with focus on Z-LWC relationships.

    SciTech Connect

    Liu,Y.; Daum, P.H.; Yum, S.S.; Wang, J.

    2008-05-01

    Cloud droplet size distributions hence the key microphysical quantities (e.g., radar reflectivity, droplet concentration, liquid water content, relative dispersion, and mean-volume radius) are determined by different physical mechanisms, including pre-cloud aerosols as CCNs, cloud updraft, and various turbulent entrainment-mixing processes. Therefore, different relationships among these microphysical properties are expected in response to these various mechanisms. The effect of turbulent entrainment-mixing processes is particularly vexing, with different entrainment-mixing processes likely leading to different microphysical relationships. Cloud radar has been widely used to infer the cloud liquid water content (L) from the measurement of radar reflectivity (Z) using a Z-L relationship. Existing Z-L expressions have been often obtained empirically, and differ substantially (Khain et al. 2008). The discrepancy among Z-L relations, which has been hindering the application of cloud radar in measuring cloud properties, likely stems from the different relationships between the relevant microphysical properties caused by different physical processes. This study first analyzes the Z-L relationship theoretically, and identify the key microphysical properties that affect this relationship, and then address the effects of various processes on the Z-L relationship by discerning the characteristics of the relationships between the relative dispersion, droplet concentration, liquid water content, and mean-volume radius calculated from in-situ measurements of cloud droplet size distributions. Effort is also made to further relate the microphysical relationships to physical processes such as turbulent entrainment-mixing.

  9. Superconductivity in SrNi2P2 single crystals

    SciTech Connect

    Ronning, Filip; Bauer, Eric D; Park, Tuscon; Thompson, Joe D

    2009-01-01

    Heat capacity, magnetic susceptibility, and resistivity of SrNi{sub 2}P{sub 2} single crystals are presented, illustrating the structural transition at 325 K, and bulk superconductivity at 1.4 K. The magnitude of {Tc}, fits to the heat capacity data, the small upper critical field H{sub c2} = 390 Oe, and {kappa} = 2.1 suggests a conventional fully gapped superconductor. With applied pressure we find that superconductivity persists into the so-called 'collapsed tetragonal' phase, although the transition temperature is monotonically suppressed with increasing pressure. This argues that reduced dimensionality can be a mechanism for increasing the transition temperatures of layered NiP, as well as layered FeAs and NiAs, superconductors.

  10. Formation and function of the Rbl2p-beta-tubulin complex.

    PubMed

    Archer, J E; Magendantz, M; Vega, L R; Solomon, F

    1998-03-01

    The yeast protein Rbl2p suppresses the deleterious effects of excess beta-tubulin as efficiently as does alpha-tubulin. Both in vivo and in vitro, Rbl2p forms a complex with beta-tubulin that does not contain alpha-tubulin, thus defining a second pool of beta-tubulin in the cell. Formation of the complex depends upon the conformation of beta-tubulin. Newly synthesized beta-tubulin can bind to Rbl2p before it binds to alpha-tubulin. Rbl2p can also bind beta-tubulin from the alpha/beta-tubulin heterodimer, apparently by competing with alpha-tubulin. The Rbl2p-beta-tubulin complex has a half-life of approximately 2.5 h and is less stable than the alpha/beta-tubulin heterodimer. The results of our experiments explain both how excess Rbl2p can rescue cells overexpressing beta-tubulin and how it can be deleterious in a wild-type background. They also suggest that the Rbl2p-beta-tubulin complex is part of a cellular mechanism for regulating the levels and dimerization of tubulin chains. PMID:9488492

  11. Supporting Collaboration and Creativity Through Mobile P2P Computing

    NASA Astrophysics Data System (ADS)

    Wierzbicki, Adam; Datta, Anwitaman; Żaczek, Łukasz; Rzadca, Krzysztof

    Among many potential applications of mobile P2P systems, collaboration applications are among the most prominent. Examples of applications such as Groove (although not intended for mobile networks), collaboration tools for disaster recovery (the WORKPAD project), and Skype's collaboration extensions, all demonstrate the potential of P2P collaborative applications. Yet, the development of such applications for mobile P2P systems is still difficult because of the lack of middleware.

  12. Interatomic Coulombic decay following resonant core excitation of Ar in argon dimer

    SciTech Connect

    Miteva, T.; Chiang, Y.-C.; Kuleff, A. I.; Gokhberg, K. Cederbaum, L. S.; Kolorenč, P.

    2014-08-14

    A scheme utilizing excitation of core electrons followed by the resonant-Auger – interatomic Coulombic decay (RA-ICD) cascade was recently proposed as a means of controlling the generation site and energies of slow ICD electrons. This control mechanism was verified in a series of experiments in rare gas dimers. In this article, we present fully ab initio computed ICD electron and kinetic energy release spectra produced following 2p{sub 3/2} → 4s, 2p{sub 1/2} → 4s, and 2p{sub 3/2} → 3d core excitations of Ar in Ar{sub 2}. We demonstrate that the manifold of ICD states populated in the resonant Auger process comprises two groups. One consists of lower energy ionization satellites characterized by fast interatomic decay, while the other consists of slow decaying higher energy ionization satellites. We show that accurate description of nuclear dynamics in the latter ICD states is crucial for obtaining theoretical electron and kinetic energy release spectra in good agreement with the experiment.

  13. Gating, Regulation, and Structure in K2P K+ Channels: In Varietate Concordia?

    PubMed

    Niemeyer, María Isabel; Cid, L Pablo; González, Wendy; Sepúlveda, Francisco V

    2016-09-01

    K2P K(+) channels with two pore domains in tandem associate as dimers to produce so-called background conductances that are regulated by a variety of stimuli. Whereas gating in K2P channels has been poorly understood, recent developments have provided important clues regarding the gating mechanism for this family of proteins. Two modes of gating present in other K(+) channels have been considered. The first is the so-called activation gating that occurs by bundle crossing and the splaying apart of pore-lining helices commanding ion passage. The second mode involves a change in conformation at the selectivity filter (SF), which impedes ion flow at this narrow portion of the conduction pathway and accounts for extracellular pH modulation of several K2P channels. Although some evidence supports the existence of an activation gate in K2P channels, recent results suggest that perhaps all stimuli, even those sensed at a distant location in the protein, are also mediated by SF gating. Recently resolved crystal structures of K2P channels in conductive and nonconductive conformations revealed that the nonconductive state is reached by blockade by a lipid acyl chain that gains access to the channel cavity through intramembrane fenestrations. Here we discuss whether this novel type of gating, proposed so far only for membrane tension gating, might mediate gating in response to other stimuli or whether SF gating is the only type of opening/closing mechanism present in K2P channels. PMID:27268784

  14. Deletion of GOLGA2P3Y but not GOLGA2P2Y is a risk factor for oligozoospermia.

    PubMed

    Sen, Sanjukta; Agarwal, Rupesh; Ambulkar, Prafulla; Hinduja, Indira; Zaveri, Kusum; Gokral, Jyotsna; Pal, Asoke; Modi, Deepak

    2016-02-01

    The AZFc locus on the human Y chromosome harbours several multicopy genes, some of which are required for spermatogenesis. It is believed that deletion of one or more copies of these genes is a cause of infertility in some men. GOLGA2LY is one of the genes in the AZFc locus and it exists in two copies, GOLGA2P2Y and GOLGA2P3Y. The involvement of GOLGA2LY gene copy deletions in male infertility, however, is unknown. This study aimed to investigate the association of deletions of GOLGA2P2Y and GOLGA2P3Y gene copies with male infertility and with sperm concentration and motility. The frequency of GOLGA2P3Y deletion was significantly higher in oligozoospermic men compared with normozoospermic men (7.7% versus 1.2%; P = 0.0001), whereas the frequency of GOLGA2P2Y deletion was comparable between oligozoospermic and normozoospermic men (10.3% versus 11.3%). The deletion of GOLGA2P3Y but not GOLGA2P2Y was significantly higher (P = 0.03) in men with gr/gr rearrangements, indicating that GOLGA2P3Y deletions increase the susceptibility of men with gr/gr rearrangements to oligozoospermia. Furthermore, men with GOLGA2P3Y deletion had reduced sperm concentration and motility compared with men without deletion or with deletion of GOLGA2P2Y. These findings indicate GOLGA2P3Y gene copy may be candidate AZFc gene for male infertility. PMID:26655651

  15. Lifetime measurement of the Ar XIV 1s{sup 2}2s{sup 2}2p {sup 2}P{sub 3/2}{sup o} metastable level at the Heidelberg electron-beam ion trap

    SciTech Connect

    Lapierre, A.; Crespo Lopez-Urrutia, J. R.; Braun, J.; Brenner, G.; Bruhns, H.; Fischer, D.; Gonzalez Martinez, A. J.; Mironov, V.; Osborne, C.; Sikler, G.; Soria Orts, R.; Tawara, H.; Ullrich, J.; Shabaev, V. M.; Tupitsyn, I. I.; Volotka, A.

    2006-05-15

    We present the details of an accurate lifetime measurement of the 1s{sup 2}2s{sup 2}2p {sup 2}P{sub 3/2}{sup o} metastable level in boronlike Ar XIV performed at the Heidelberg electron beam ion trap [A. Lapierre et al., Phys. Rev. Lett. 95, 183001 (2005)]. The lifetime was inferred from decay curves resulting from deexcitation of the metastable level to its {sup 2}P{sub 1/2}{sup o} ground state through a magnetic-dipole (M1) transition upon cyclically turning on and off the electron beam. The measured lifetime of 9.573(4)((+12/-5)) ms (stat)(syst) is in disagreement with a trend of theoretical predictions of 9.53(1) ms, which include the effect of the electron anomalous magnetic moment. Systematic effects were investigated by studying with high statistical significance the dependence of the decay times of the curves on various trapping conditions. The asymptotic trend of the decay times observed for increasingly high trapping potentials, which indicates negligible ion losses within a ms time scale, is in agreement with a theoretical model describing the ion escape rate in electrostatic ion traps. However, for high trapping potentials, we observed an unexpected slowly decaying component suggesting the presence of trapped low-energy electrons. Their origin, dynamics, and temperature, as well as their possible effects on the measured lifetime were investigated.

  16. Seal Out Tooth Decay

    MedlinePlus

    ... Topics > Tooth Decay (Caries) > Seal Out Tooth Decay Seal Out Tooth Decay Main Content What are dental ... back teeth decay so easily? Who should get seal​ants? Should sealants be put on baby teeth? ...

  17. An Efficient, Scalable and Robust P2P Overlay for Autonomic Communication

    NASA Astrophysics Data System (ADS)

    Li, Deng; Liu, Hui; Vasilakos, Athanasios

    The term Autonomic Communication (AC) refers to self-managing systems which are capable of supporting self-configuration, self-healing and self-optimization. However, information reflection and collection, lack of centralized control, non-cooperation and so on are just some of the challenges within AC systems. Since many self-* properties (e.g. selfconfiguration, self-optimization, self-healing, and self-protecting) are achieved by a group of autonomous entities that coordinate in a peer-to-peer (P2P) fashion, it has opened the door to migrating research techniques from P2P systems. P2P's meaning can be better understood with a set of key characteristics similar to AC: Decentralized organization, Self-organizing nature (i.e. adaptability), Resource sharing and aggregation, and Fault-tolerance. However, not all P2P systems are compatible with AC. Unstructured systems are designed more specifically than structured systems for the heterogeneous Internet environment, where the nodes' persistence and availability are not guaranteed. Motivated by the challenges in AC and based on comprehensive analysis of popular P2P applications, three correlative standards for evaluating the compatibility of a P2P system with AC are presented in this chapter. According to these standards, a novel Efficient, Scalable and Robust (ESR) P2P overlay is proposed. Differing from current structured and unstructured, or meshed and tree-like P2P overlay, the ESR is a whole new three dimensional structure to improve the efficiency of routing, while information exchanges take in immediate neighbors with local information to make the system scalable and fault-tolerant. Furthermore, rather than a complex game theory or incentive mechanism, asimple but effective punish mechanism has been presented based on a new ID structure which can guarantee the continuity of each node's record in order to discourage negative behavior on an autonomous environment as AC.

  18. The importance of L1 ORF2p cryptic sequence to ORF2p fragment-mediated cytotoxicity.

    PubMed

    Christian, Claiborne M; Kines, Kristine J; Belancio, Victoria P

    2016-01-01

    The Long Interspersed Element 1 (LINE1 or L1) ORF2 protein (ORF2p) can cause DNA damage through the activity of its endonuclease domain (EN). The DNA double-strand breaks (DSB) introduced by the ORF2p EN have the potential to be mutagenic. Previously, our lab has shown that ORF2p fragments containing the EN domain could be expressed in mammalian cells and have variable cytotoxicity. Inclusion of the ORF2p sequence C-terminal to the EN domain in these fragments both reduced the cytotoxicity of these fragments and increased their presence in the nucleus as detected by Western blot analysis. Here, we identify the amino acids (aa 270-274) in the newly-identified ORF2p Cryptic region (Cry) that may be important to the subcellular localization and cytotoxic potential of these EN-containing ORF2p fragments. PMID:27583184

  19. The importance of L1 ORF2p cryptic sequence to ORF2p fragment-mediated cytotoxicity

    PubMed Central

    Christian, Claiborne M.; Kines, Kristine J.; Belancio, Victoria P.

    2016-01-01

    ABSTRACT The Long Interspersed Element 1 (LINE1 or L1) ORF2 protein (ORF2p) can cause DNA damage through the activity of its endonuclease domain (EN). The DNA double-strand breaks (DSB) introduced by the ORF2p EN have the potential to be mutagenic. Previously, our lab has shown that ORF2p fragments containing the EN domain could be expressed in mammalian cells and have variable cytotoxicity. Inclusion of the ORF2p sequence C-terminal to the EN domain in these fragments both reduced the cytotoxicity of these fragments and increased their presence in the nucleus as detected by Western blot analysis. Here, we identify the amino acids (aa 270–274) in the newly-identified ORF2p Cryptic region (Cry) that may be important to the subcellular localization and cytotoxic potential of these EN-containing ORF2p fragments. PMID:27583184

  20. Isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions

    NASA Astrophysics Data System (ADS)

    Zubova, N. A.; Malyshev, A. V.; Tupitsyn, I. I.; Shabaev, V. M.; Kozhedub, Y. S.; Plunien, G.; Brandau, C.; Stöhlker, Th.

    2016-05-01

    Isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions are evaluated for a wide range of the nuclear charge number: Z =8 -92 . The calculations of the relativistic nuclear recoil and nuclear size effects are performed using a large-scale configuration-interaction Dirac-Fock-Sturm method. The corresponding QED corrections are also taken into account. The results of the calculations are compared with the theoretical values obtained with other methods. The accuracy of the isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions is significantly improved.

  1. Nucleophilic substitution at phosphorus centers (SN2@p).

    PubMed

    van Bochove, Marc A; Swart, Marcel; Bickelhaupt, F Matthias

    2007-12-01

    We have studied the characteristics of archetypal model systems for bimolecular nucleophilic substitution at phosphorus (SN2@P) and, for comparison, at carbon (SN2@C) and silicon (SN2@Si) centers. In our studies, we applied the generalized gradient approximation (GGA) of density functional theory (DFT) at the OLYP/TZ2P level. Our model systems cover nucleophilic substitution at carbon in X(-)+CH3Y (SN2@C), at silicon in X(-)+SiH3Y (SN2@Si), at tricoordinate phosphorus in X(-)+PH2Y (SN2@P3), and at tetracoordinate phosphorus in X(-)+POH2Y (SN2@P4). The main feature of going from SN2@C to SN2@P is the loss of the characteristic double-well potential energy surface (PES) involving a transition state [X--CH3--Y]- and the occurrence of a single-well PES with a stable transition complex, namely, [X--PH2--Y]- or [X--POH2--Y](-). The differences between SN2@P3 and SN2@P4 are relatively small. We explored both the symmetric and asymmetric (i.e. X, Y=Cl, OH) SN2 reactions in our model systems, the competition between backside and frontside pathways, and the dependence of the reactions on the conformation of the reactants. Furthermore, we studied the effect, on the symmetric and asymmetric SN2@P3 and S(N)2@P4 reactions, of replacing hydrogen substituents at the phosphorus centers by chlorine and fluorine in the model systems X(-)+PR2Y and X(-)+POR2Y, with R=Cl, F. An interesting phenomenon is the occurrence of a triple-well PES not only in the symmetric, but also in the asymmetric SN2@P4 reactions of X(-)+POCl2--Y. PMID:17990249

  2. Study of the SEE decay processes in application to mechanisms of dissipation of the HF plasma turbulence and diagnostics of the ionospheric plasma parameters

    NASA Astrophysics Data System (ADS)

    Sergeev, Evgeny

    Results of the investigations of the decay process for different stimulated electromagnetic emission (SEE) features at the SURA heating facility (Russia) are presented. The data of the measurements are used to analyze the nonlinear energy transformation through the spectra of the Langmuir and upper hybrid plasma turbulence as well as to determine a relationship between the electron collision frequency and the collisionless decay rate of the plasma waves under different ionospheric conditions. In particular, due to the SEE decay time measurements at the upper hybrid turbulence development stage it is found an increase of the decay rate γ of the emission from the collision values γ = τ -1 = 300 - 400 s-1 to the collisionless values γ = 2000 - 10000 s-1 in a wide frequency band (up to 600 kHz) near the 4th - 7th cyclotron electron gyroharmonics. On the other hand, the SEE decay times didn't found any dependence on the pump power but they slightly increase under change from day to night condition. The results of the daily SEE decay rate monitoring in dependence on the pumping frequency (re- flection altitude) are presented. The work was supported by RFBR grants 07-02-00464 and 06-02-17334.

  3. Structure And Function of the Yeast U-Box-Containing Ubiquitin Ligase Ufd2p

    SciTech Connect

    Tu, D.; Li, W.; Ye, Y.; Brunger, A.T.

    2009-06-04

    Proteins conjugated by Lys-48-linked polyubiquitin chains are preferred substrates of the eukaryotic proteasome. Polyubiquitination requires an activating enzyme (E1), a conjugating enzyme (E2), and a ligase (E3). Occasionally, these enzymes only assemble short ubiquitin oligomers, and their extension to full length involves a ubiquitin elongating factor termed E4. Ufd2p, as the first E4 identified to date, is involved in the degradation of misfolded proteins of the endoplasmic reticulum and of a ubiquitin-{beta}-GAL fusion substrate in Saccharomyces cerevisiae. The mechanism of action of Ufd2p is unknown. Here we describe the crystal structure of the full-length yeast Ufd2p protein. Ufd2p has an elongated shape consisting of several irregular Armadillo-like repeats with two helical hairpins protruding from it and a U-box domain flexibly attached to its C terminus. The U-box of Ufd2p has a fold similar to that of the RING (Really Interesting New Gene) domain that is present in certain ubiquitin ligases. Accordingly, Ufd2p has all of the hallmarks of a RING finger-containing ubiquitin ligase: it associates with its cognate E2 Ubc4p via its U-box domain and catalyzes the transfer of ubiquitin from the E2 active site to Ufd2p itself or to an acceptor ubiquitin molecule to form unanchored diubiquitin oligomers. Thus, Ufd2p can function as a bona fide E3 ubiquitin ligase to promote ubiquitin chain elongation on a substrate.

  4. P2P-based botnets: structural analysis, monitoring, and mitigation

    SciTech Connect

    Yan, Guanhua; Eidenbenz, Stephan; Ha, Duc T; Ngo, Hung Q

    2008-01-01

    Botnets, which are networks of compromised machines that are controlled by one or a group of attackers, have emerged as one of the most serious security threats on the Internet. With an army of bots at the scale of tens of thousands of hosts or even as large as 1.5 million PCs, the computational power of botnets can be leveraged to launch large-scale DDoS (Distributed Denial of Service) attacks, sending spamming emails, stealing identities and financial information, etc. As detection and mitigation techniques against botnets have been stepped up in recent years, attackers are also constantly improving their strategies to operate these botnets. The first generation of botnets typically employ IRC (Internet Relay Chat) channels as their command and control (C&C) centers. Though simple and easy to deploy, the centralized C&C mechanism of such botnets has made them prone to being detected and disabled. Against this backdrop, peer-to-peer (P2P) based botnets have emerged as a new generation of botnets which can conceal their C&C communication. Recently, P2P networks have emerged as a covert communication platform for malicious programs known as bots. As popular distributed systems, they allow bots to communicate easily while protecting the botmaster from being discovered. Existing work on P2P-based hotnets mainly focuses on measurement of botnet sizes. In this work, through simulation, we study extensively the structure of P2P networks running Kademlia, one of a few widely used P2P protocols in practice. Our simulation testbed incorporates the actual code of a real Kademlia client software to achieve great realism, and distributed event-driven simulation techniques to achieve high scalability. Using this testbed, we analyze the scaling, reachability, clustering, and centrality properties of P2P-based botnets from a graph-theoretical perspective. We further demonstrate experimentally and theoretically that monitoring bot activities in a P2P network is difficult

  5. Secure mobile agent for telemedicine based on P2P networks.

    PubMed

    Hsu, Wen-Shin; Pan, Jiann-I

    2013-06-01

    Exploring intelligent mobile agent (MA) technology for assisting medical services or transmitting personal patient-health information in telemedicine applications has been widely investigated. Conversely, peer-to-peer (P2P) networking has become one of the most popular applications used in the Internet because of its benefits for easy-to-manage resources and because it balances workloads. Therefore, constructing an agent-based telemedicine platform based on P2P networking architecture is necessary. The main purpose of this paper is to construct a safe agent-based telemedicine that based on P2P networking architecture. Two themes are addressed in this paper: (a) the P2P network architecture for an agent-based telemedicine service, and (b) the security mechanisms for the proposed telemedicine networking architecture. When an MA contains patient information and migrates from one host to another through the Internet, it can be attacked by other software agents or agent platforms that can illegally access patient information. The proposed P2P network architecture is based on the JXTA protocol and provides two types of telemedicine service models: the predictable service model and unpredictable service model. This architecture employs a two-layer safety mechanism for MAs (i.e., time-limited black boxes and RSA undetachable signature technologies), to provide a secure solution for agent-based telemedicine services. PMID:23605144

  6. A Role for K2P Channels in the Operation of Somatosensory Nociceptors

    PubMed Central

    Plant, Leigh D.

    2012-01-01

    The ability to sense mechanical, thermal, and chemical stimuli is critical to normal physiology and the perception of pain. Contact with noxious stimuli triggers a complex series of events that initiate innate protective mechanisms designed to minimize or avoid injury. Extreme temperatures, mechanical stress, and chemical irritants are detected by specific ion channels and receptors clustered on the terminals of nociceptive sensory nerve fibers and transduced into electrical information. Propagation of these signals, from distant sites in the body to the spinal cord and the higher processing centers of the brain, is also orchestrated by distinct groups of ion channels. Since their identification in 1995, evidence has emerged to support roles for K2P channels at each step along this pathway, as receptors for physiological and noxious stimuli, and as determinants of nociceptor excitability and conductivity. In addition, the many subtypes of K2P channels expressed in somatosensory neurons are also implicated in mediating the effects of volatile, general anesthetics on the central and peripheral nervous systems. Here, I offer a critical review of the existing data supporting these attributes of K2P channel function and discuss how diverse regulatory mechanisms that control the activity of K2P channels act to govern the operation of nociceptors. PMID:22403526

  7. Trisomy 2p: Analysis of unusual phenotypic findings

    SciTech Connect

    Lurie, I.W.; Ilyina, H.G.; Gurevich, D.B.

    1995-01-16

    We present three probands with partial trisomies 2p21-23 due to ins(4;2)(q21;p21p23) pat, 2p23-pter due to t(2;4)(p23;q35)mat, and 2p21-pter due to t(2;11)(p21;q23.3)mat. More than 50 cases of partial trisomy 2p have been reviewed and some abnormalities, unusual for most other types of structural autosomal imbalance, have been found in patients with inherited forms of 2p trisomy and in their non-karyotyped sibs. Neural tube defects (anencephaly, occipital encephalocele, and spina bifida) were found in five probands and 4/6 affected non-karyotyped sibs. The only triplicated segment common to all was 2p24. Different forms of {open_quotes}broncho-pulmonary a/hypoplasia{close_quotes} (including two cases of lung agenesis) were described in four patients (overlapping triplicated segment was 2p21-p25). Three patients (with overlapping triplicated segment 2p23-p25) had diaphragmatic hernia. Abnormal rotation of the heart or L-transposition of large vessels (with or without visceral heterotaxia) was found in two infants (overlapping triplicated segment 2p23-p24). In two patients with common triplicated segment 2p22.3-p25, neuroblastoma has been described. The occurrence of all these defects may be explained either by the action of the same gene(s) mapped to 2p24 or by action of some independent factors located in different segments of the short arm. Although the latter hypothesis is much less probable, it can not be rejected at the present time. We propose the existence of a genetic system controlling surveillance of an abnormal embryo to explain the phenotypic differences between patients with the same imbalance within a family. In some {open_quotes}restrictive{close_quotes} combinations the abnormal embryos will die, although in {open_quotes}permissive{close_quotes} combinations they can survive. 47 refs., 2 figs., 3 tabs.

  8. Network Awareness in P2P-TV Applications

    NASA Astrophysics Data System (ADS)

    Traverso, Stefano; Leonardi, Emilio; Mellia, Marco; Meo, Michela

    The increasing popularity of applications for video-streaming based on P2P paradigm (P2P-TV) is raising the interest of both broadcasters and network operators. The former see a promising technology to reduce the cost of streaming content over the Internet, while offering a world-wide service. The latter instead fear that the traffic offered by these applications can grow without control, affecting other services, and possibly causing network congestion and collapse. The “Network-Aware P2P-TV Application over Wise Networks” FP7 project aims at studying and developing a novel P2P-TV application offering the chance to broadcast high definition video to broadcasters and to carefully manage the traffic offered by peers to the network, therefore avoiding worries to Internet providers about network overload. In such context, we design a simulator to evaluate performance of different P2P-TV solutions, to compare them both considering end-users’ and network providers’ perspectives, such as quality of service perceived by subscribers and link utilization. In this paper, we provide some results that show how effective can be a network aware P2P-TV system.

  9. Improving P2P live-content delivery using SVC

    NASA Astrophysics Data System (ADS)

    Schierl, T.; Sánchez, Y.; Hellge, C.; Wiegand, T.

    2010-07-01

    P2P content delivery techniques for video transmission have become of high interest in the last years. With the involvement of client into the delivery process, P2P approaches can significantly reduce the load and cost on servers, especially for popular services. However, previous studies have already pointed out the unreliability of P2P-based live streaming approaches due to peer churn, where peers may ungracefully leave the P2P infrastructure, typically an overlay networks. Peers ungracefully leaving the system cause connection losses in the overlay, which require repair operations. During such repair operations, which typically take a few roundtrip times, no data is received from the lost connection. While taking low delay for fast-channel tune-in into account as a key feature for broadcast-like streaming applications, the P2P live streaming approach can only rely on a certain media pre-buffer during such repair operations. In this paper, multi-tree based Application Layer Multicast as a P2P overlay technique for live streaming is considered. The use of Flow Forwarding (FF), a.k.a. Retransmission, or Forward Error Correction (FEC) in combination with Scalable video Coding (SVC) for concealment during overlay repair operations is shown. Furthermore the benefits of using SVC over the use of AVC single layer transmission are presented.

  10. Semileptonic Decays

    SciTech Connect

    Luth, Vera G.; /SLAC

    2012-10-02

    The following is an overview of the measurements of the CKM matrix elements |V{sub cb}| and |V{sub ub}| that are based on detailed studies of semileptonic B decays by the BABAR and Belle Collaborations and major advances in QCD calculations. In addition, a new and improved measurement of the ratios R(D{sup (*)}) = {Beta}({bar B} {yields} D{sup (*)}{tau}{sup -}{bar {nu}}{sub {tau}})/{Beta}({bar B} {yields} D{sup (*)}{ell}{sup -}{bar {nu}}{sub {ell}}) is presented. Here D{sup (*)} refers to a D or a D* meson and {ell} is either e or {mu}. The results, R(D) = 0.440 {+-} 0.058 {+-} 0.042 and R(D*) = 0.332 {+-} 0.024 {+-} 0.018, exceed the Standard Model expectations by 2.0{sigma} and 2.7{sigma}, respectively. Taken together, they disagree with these expectations at the 3.4{sigma} level. The excess of events cannot be explained by a charged Higgs boson in the type II two-Higgs-doublet model.

  11. Dental Caries (Tooth Decay)

    MedlinePlus

    ... Find Data by Topic > Dental Caries (Tooth Decay) Dental Caries (Tooth Decay) Main Content Dental caries (tooth decay) remains the most prevalent chronic ... important source of information on oral health and dental care in the United States since the early ...

  12. The N2-P3 complex of the evoked potential and human performance

    NASA Technical Reports Server (NTRS)

    Odonnell, Brian F.; Cohen, Ronald A.

    1988-01-01

    The N2-P3 complex and other endogenous components of human evoked potential provide a set of tools for the investigation of human perceptual and cognitive processes. These multidimensional measures of central nervous system bioelectrical activity respond to a variety of environmental and internal factors which have been experimentally characterized. Their application to the analysis of human performance in naturalistic task environments is just beginning. Converging evidence suggests that the N2-P3 complex reflects processes of stimulus evaluation, perceptual resource allocation, and decision making that proceed in parallel, rather than in series, with response generation. Utilization of these EP components may provide insights into the central nervous system mechanisms modulating task performance unavailable from behavioral measures alone. The sensitivity of the N2-P3 complex to neuropathology, psychopathology, and pharmacological manipulation suggests that these components might provide sensitive markers for the effects of environmental stressors on the human central nervous system.

  13. The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production.

    PubMed

    Schmid, Manfred; Olszewski, Pawel; Pelechano, Vicent; Gupta, Ishaan; Steinmetz, Lars M; Jensen, Torben Heick

    2015-07-01

    Polyadenylation of mRNA is a key step in eukaryotic gene expression. However, despite the major impact of poly(A) tails on mRNA metabolism, the precise roles of poly(A)-binding proteins (PABPs) in nuclear mRNA biogenesis remain elusive. Here, we demonstrate that rapid nuclear depletion of the S. cerevisiae PABP Nab2p leads to a global loss of cellular mRNA, but not of RNA lacking poly(A) tails. Disappearance of mRNA is a nuclear event, but not due to decreased transcription. Instead, the absence of Nab2p results in robust nuclear mRNA decay by the ribonucleolytic RNA exosome in a polyadenylation-dependent process. We conclude that Nab2p is required to protect early mRNA and therefore constitutes a crucial nuclear mRNA biogenesis factor. PMID:26119729

  14. Ptc1p regulates cortical ER inheritance via Slt2p.

    PubMed

    Du, Yunrui; Walker, Lee; Novick, Peter; Ferro-Novick, Susan

    2006-10-01

    Studies in the yeast Saccharomyces cerevisiae have shown that the inheritance of endoplasmic reticulum (ER), mitochondria, and vacuoles involves the capture of a tubular structure at the bud tip. Ptc1p, a serine/threonine phosphatase, has previously been shown to regulate mitochondrial inheritance by an unknown mechanism. Ptc1p regulates the high osmolarity glycerol mitogen-activated protein kinase (MAPK) pathway and has also been implicated in the cell wall integrity (CWI) MAPK pathway. Here we show that the loss of Ptc1p or the Ptc1p binding protein, Nbp2p, causes a prominent delay in the delivery of ER tubules to the periphery of daughter cells and results in a dramatic increase in the level of phosphorylated Slt2p, the MAPK in the CWI pathway. Either loss of Slt2p or inhibition of the CWI pathway by addition of sorbitol, suppresses the ER inheritance defect in the ptc1Delta and nbp2Delta mutants. Our findings indicate that Ptc1p and Nbp2p regulate ER inheritance through the CWI MAPK pathway by modulating the MAPK, Slt2p. PMID:16977319

  15. The Clathrin Adaptor Gga2p Is a Phosphatidylinositol 4-phosphate Effector at the Golgi Exit

    PubMed Central

    Demmel, Lars; Gravert, Maike; Ercan, Ebru; Habermann, Bianca; Müller-Reichert, Thomas; Kukhtina, Viktoria; Haucke, Volker; Baust, Thorsten; Sohrmann, Marc; Kalaidzidis, Yannis; Klose, Christian; Beck, Mike; Peter, Matthias

    2008-01-01

    Phosphatidylinositol 4-phosphate (PI(4)P) is a key regulator of membrane transport required for the formation of transport carriers from the trans-Golgi network (TGN). The molecular mechanisms of PI(4)P signaling in this process are still poorly understood. In a search for PI(4)P effector molecules, we performed a screen for synthetic lethals in a background of reduced PI(4)P and found the gene GGA2. Our analysis uncovered a PI(4)P-dependent recruitment of the clathrin adaptor Gga2p to the TGN during Golgi-to-endosome trafficking. Gga2p recruitment to liposomes is stimulated both by PI(4)P and the small GTPase Arf1p in its active conformation, implicating these two molecules in the recruitment of Gga2p to the TGN, which ultimately controls the formation of clathrin-coated vesicles. PI(4)P binding occurs through a phosphoinositide-binding signature within the N-terminal VHS domain of Gga2p resembling a motif found in other clathrin interacting proteins. These data provide an explanation for the TGN-specific membrane recruitment of Gga2p. PMID:18287542

  16. Large-Scale Mini-Magnetosphere Plasma Propulsion (M2P2) Experiments

    NASA Technical Reports Server (NTRS)

    Winglee, R. M.; Slough, J.; Ziemba, T.; Euripides, P.; Adrian, M. L.; Gallagher, D.; Craven, P.; Tomlinson, W.; Cravens, J.; Burch, J.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    Mini-Magnetosphere Plasma Propulsion (M2P2) is an innovative plasma propulsion system that has the potential to propel spacecraft at unprecedented speeds of 50 to 80 km per second with a low-power requirement of approx. 1 kW per 100 kg of payload and approx. 1 kg of neutral gas [fuel] consumption per day of acceleration. Acceleration periods from several days to a few months are envisioned. High specific impulse and efficiency are achieved through coupling of the spacecraft to the 400 km per second solar wind through an artificial magnetosphere. The mini-magnetosphere or inflated magnetic bubble is produced by the injection of cold dense plasma into a spacecraft-generated magnetic field envelope. Magnetic bubble inflation is driven by electromagnetic processes thereby avoiding the material and deployment problems faced by mechanical solar sail designs, Here, we present the theoretical design of M2P2 as well as initial results from experimental testing of an M2P2 prototype demonstrating: 1) inflation of the dipole magnetic field geometry through the internal injection of cold plasma; and 2) deflection of and artificial solar wind by the prototype M2P2 system. In addition, we present plans for direct laboratory measurement of thrust imparted to a prototype M2P2 by an artificial solar wind during the summer of 2001.

  17. Large-Scale Mini-Magnetosphere Plasma Propulsion (M2P2) Experiments

    NASA Technical Reports Server (NTRS)

    Winglee, R. M.; Slough, J.; Ziemba, T.; Euripides, P.; Gallagher, D.; Craven, P.; Adrian, M. L.; Tomlinson, W.; Cravens, J.; Burch, J.; Rose, M. Franklin (Technical Monitor)

    2001-01-01

    Mini-Magnetosphere Plasma Propulsion (M2P2) is an innovative plasma propulsion system that has the potential to propel spacecraft at unprecedented speeds of 50 to 80 km/s, with a low power requirement of approx. 1 kW per 100 kg of payload and -1 kg of neutral gas [fuel] consumption per day of acceleration. Acceleration periods from several days to a few months are envisioned. High specific impulse and efficiency are achieved through coupling of the spacecraft to the 400 km/s. solar wind through an artificial magnetosphere. The mini-magnetosphere or inflated magnetic bubble is produced by the injection of cold dense plasma into a spacecraft-generated magnetic field envelope. Magnetic bubble inflation is driven by electromagnetic processes thereby avoiding the material and deployment problems faced by mechanical solar sail designs. Here, we present the theoretical design of M2P2 as well as initial results from experimental testing of an M2P2 prototype demonstrating: 1) inflation of the dipole magnetic field geometry through the internal injection of cold plasma; and 2) deflection of and artificial solar wind by the prototype M2P2 system. In addition, we present plans for direct laboratory measurement of thrust imparted to a prototype M2P2 by an artificial solar wind during the summer of 2001.

  18. Determinants of Default in P2P Lending.

    PubMed

    Serrano-Cinca, Carlos; Gutiérrez-Nieto, Begoña; López-Palacios, Luz

    2015-01-01

    This paper studies P2P lending and the factors explaining loan default. This is an important issue because in P2P lending individual investors bear the credit risk, instead of financial institutions, which are experts in dealing with this risk. P2P lenders suffer a severe problem of information asymmetry, because they are at a disadvantage facing the borrower. For this reason, P2P lending sites provide potential lenders with information about borrowers and their loan purpose. They also assign a grade to each loan. The empirical study is based on loans' data collected from Lending Club (N = 24,449) from 2008 to 2014 that are first analyzed by using univariate means tests and survival analysis. Factors explaining default are loan purpose, annual income, current housing situation, credit history and indebtedness. Secondly, a logistic regression model is developed to predict defaults. The grade assigned by the P2P lending site is the most predictive factor of default, but the accuracy of the model is improved by adding other information, especially the borrower's debt level. PMID:26425854

  19. Determinants of Default in P2P Lending

    PubMed Central

    2015-01-01

    This paper studies P2P lending and the factors explaining loan default. This is an important issue because in P2P lending individual investors bear the credit risk, instead of financial institutions, which are experts in dealing with this risk. P2P lenders suffer a severe problem of information asymmetry, because they are at a disadvantage facing the borrower. For this reason, P2P lending sites provide potential lenders with information about borrowers and their loan purpose. They also assign a grade to each loan. The empirical study is based on loans’ data collected from Lending Club (N = 24,449) from 2008 to 2014 that are first analyzed by using univariate means tests and survival analysis. Factors explaining default are loan purpose, annual income, current housing situation, credit history and indebtedness. Secondly, a logistic regression model is developed to predict defaults. The grade assigned by the P2P lending site is the most predictive factor of default, but the accuracy of the model is improved by adding other information, especially the borrower’s debt level. PMID:26425854

  20. Protecting Data Privacy in Structured P2P Networks

    NASA Astrophysics Data System (ADS)

    Jawad, Mohamed; Serrano-Alvarado, Patricia; Valduriez, Patrick

    P2P systems are increasingly used for efficient, scalable data sharing. Popular applications focus on massive file sharing. However, advanced applications such as online communities (e.g., medical or research communities) need to share private or sensitive data. Currently, in P2P systems, untrusted peers can easily violate data privacy by using data for malicious purposes (e.g., fraudulence, profiling). To prevent such behavior, the well accepted Hippocratic database principle states that data owners should specify the purpose for which their data will be collected. In this paper, we apply such principles as well as reputation techniques to support purpose and trust in structured P2P systems. Hippocratic databases enforce purpose-based privacy while reputation techniques guarantee trust. We propose a P2P data privacy model which combines the Hippocratic principles and the trust notions. We also present the algorithms of PriServ, a DHT-based P2P privacy service which supports this model and prevents data privacy violation. We show, in a performance evaluation, that PriServ introduces a small overhead.

  1. Market Design for a P2P Backup System

    NASA Astrophysics Data System (ADS)

    Seuken, Sven; Charles, Denis; Chickering, Max; Puri, Sidd

    Peer-to-peer (P2P) backup systems are an attractive alternative to server-based systems because the immense costs of large data centers can be saved by using idle resources on millions of private computers instead. This paper presents the design and theoretical analysis of a market for a P2P backup system. While our long-term goal is an open resource exchange market using real money, here we consider a system where monetary transfers are prohibited. A user who wants to backup his data must in return supply some of his resources (storage space, upload and download bandwidth) to the system.We propose a hybrid P2P architecture where all backup data is transferred directly between peers, but a dedicated server coordinates all operations and maintains meta-data. We achieve high reliability guarantees while keeping our data replication factor low by adopting sophisticated erasure coding technology (cf., [2]).

  2. Fragrance material review on 2-(p-tolyloxy)ethyl acetate.

    PubMed

    McGinty, D; Letizia, C S; Api, A M

    2012-09-01

    A toxicologic and dermatologic review of 2-(p-tolyloxy)ethyl acetate when used as a fragrance ingredient is presented. 2-(p-tolyloxy)ethyl acetate is a member of the fragrance structural group aryl alkyl alcohol simple acid esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-(p-tolyloxy)ethyl acetate were evaluated, then summarized, and includes physical properties data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances. PMID:22414652

  3. Hat2p recognizes the histone H3 tail to specify the acetylation of the newly synthesized H3/H4 heterodimer by the Hat1p/Hat2p complex

    PubMed Central

    Li, Yang; Zhang, Li; Liu, Tingting; Chai, Chengliang; Fang, Qianglin; Wu, Han; Agudelo Garcia, Paula A.; Han, Zhifu; Zong, Shuai; Yu, You; Zhang, Xinyue; Parthun, Mark R.; Chai, Jijie; Xu, Rui-Ming; Yang, Maojun

    2014-01-01

    Post-translational modifications of histones are significant regulators of replication, transcription, and DNA repair. Particularly, newly synthesized histone H4 in H3/H4 heterodimers becomes acetylated on N-terminal lysine residues prior to its incorporation into chromatin. Previous studies have established that the histone acetyltransferase (HAT) complex Hat1p/Hat2p medicates this modification. However, the mechanism of how Hat1p/Hat2p recognizes and facilitates the enzymatic activities on the newly assembled H3/H4 heterodimer remains unknown. Furthermore, Hat2p is a WD40 repeat protein, which is found in many histone modifier complexes. However, how the WD40 repeat proteins facilitate enzymatic activities of histone modification enzymes is unclear. In this study, we first solved the high-resolution crystal structure of a Hat1p/Hat2p/CoA/H4 peptide complex and found that the H4 tail interacts with both Hat1p and Hat2p, by which substrate recruitment is facilitated. We further discovered that H3 N-terminal peptides can bind to the Hat2p WD40 domain and solved the structure of the Hat1p/Hat2p/CoA/H4/H3 peptide complex. Moreover, the interaction with Hat2p requires unmodified Arg2/Lys4 and Lys9 on the H3 tail, suggesting a novel model to specify the activity of Hat1p/Hat2p toward newly synthesized H3/H4 heterodimers. Together, our study demonstrated the substrate recognition mechanism by the Hat1p/Hat2p complex, which is critical for DNA replication and other chromatin remodeling processes. PMID:24835250

  4. Faraday effect in Sn2P2S6 crystals.

    PubMed

    Krupych, Oleh; Adamenko, Dmytro; Mys, Oksana; Grabar, Aleksandr; Vlokh, Rostyslav

    2008-11-10

    We have revealed a large Faraday rotation in tin thiohypodiphosphate (Sn(2)P(2)S(6)) crystals, which makes this material promising for magneto-optics. The effective Faraday tensor component and the Verdet constant for the direction of the optic axis have been determined by measuring the pure Faraday rotation in Sn(2)P(2)S(6) crystals with both the single-ray and small-angular polarimetric methods at the normal conditions and a wavelength of 632.8 nm. The effective Verdet constant is found to be equal to 115 rad/T x m. PMID:19002228

  5. Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.

    PubMed

    Lolicato, Marco; Riegelhaupt, Paul M; Arrigoni, Cristina; Clark, Kimberly A; Minor, Daniel L

    2014-12-17

    Mechanical and thermal activation of ion channels is central to touch, thermosensation, and pain. The TRAAK/TREK K(2P) potassium channel subfamily produces background currents that alter neuronal excitability in response to pressure, temperature, signaling lipids, and anesthetics. How such diverse stimuli control channel function is unclear. Here we report structures of K(2P)4.1 (TRAAK) bearing C-type gate-activating mutations that reveal a tilting and straightening of the M4 inner transmembrane helix and a buckling of the M2 transmembrane helix. These conformational changes move M4 in a direction opposite to that in classical potassium channel activation mechanisms and open a passage lateral to the pore that faces the lipid bilayer inner leaflet. Together, our findings uncover a unique aspect of K(2P) modulation, indicate a means for how the K(2P) C-terminal cytoplasmic domain affects the C-type gate which lies ∼40Å away, and suggest how lipids and bilayer inner leaflet deformations may gate the channel. PMID:25500157

  6. Proton decay theory

    SciTech Connect

    Marciano, W.J.

    1983-01-01

    Topics include minimal SU(5) predictions, gauge boson mediated proton decay, uncertainties in tau/sub p/, Higgs scalar effects, proton decay via Higgs scalars, supersymmetric SU(5), dimension 5 operators and proton decay, and Higgs scalars and proton decay. (WHK)

  7. Measurement and analysis of P2P IPTV program resource.

    PubMed

    Wang, Wenxian; Chen, Xingshu; Wang, Haizhou; Zhang, Qi; Wang, Cheng

    2014-01-01

    With the rapid development of P2P technology, P2P IPTV applications have received more and more attention. And program resource distribution is very important to P2P IPTV applications. In order to collect IPTV program resources, a distributed multi-protocol crawler is proposed. And the crawler has collected more than 13 million pieces of information of IPTV programs from 2009 to 2012. In addition, the distribution of IPTV programs is independent and incompact, resulting in chaos of program names, which obstructs searching and organizing programs. Thus, we focus on characteristic analysis of program resources, including the distributions of length of program names, the entropy of the character types, and hierarchy depth of programs. These analyses reveal the disorderly naming conventions of P2P IPTV programs. The analysis results can help to purify and extract useful information from chaotic names for better retrieval and accelerate automatic sorting of program and establishment of IPTV repository. In order to represent popularity of programs and to predict user behavior and popularity of hot programs over a period, we also put forward an analytical model of hot programs. PMID:24772008

  8. MDM2-p53 Pathway in Hepatocellular Carcinoma

    PubMed Central

    Meng, Xuan; Franklin, Derek A; Dong, Jiahong; Zhang, Yanping

    2015-01-01

    Abnormalities in the TP53 gene and overexpression of MDM2, a transcriptional target and negative regulator of p53, are commonly observed in cancers. The MDM2-p53 feedback loop plays an important role in tumor progression and thus, increased understanding of the pathway has the potential to improve clinical outcomes for cancer patients. Hepatocellular carcinoma (HCC) has emerged as one of the most commonly diagnosed forms of human cancer; yet, the current treatment for HCC is less effective than those used against other cancers. We review the current studies of the MDM2-p53 pathway in cancer with a focus on HCC, and specifically discuss the impact of p53 mutations along with other alterations of the MDM2-p53 feedback loop in HCC. We also discuss the potential diagnostic and prognostic applications of p53 and MDM2 in malignant tumors as well as therapeutic avenues that are being developed to target the MDM2-p53 pathway. PMID:25477334

  9. Measurement and Analysis of P2P IPTV Program Resource

    PubMed Central

    Chen, Xingshu; Wang, Haizhou; Zhang, Qi

    2014-01-01

    With the rapid development of P2P technology, P2P IPTV applications have received more and more attention. And program resource distribution is very important to P2P IPTV applications. In order to collect IPTV program resources, a distributed multi-protocol crawler is proposed. And the crawler has collected more than 13 million pieces of information of IPTV programs from 2009 to 2012. In addition, the distribution of IPTV programs is independent and incompact, resulting in chaos of program names, which obstructs searching and organizing programs. Thus, we focus on characteristic analysis of program resources, including the distributions of length of program names, the entropy of the character types, and hierarchy depth of programs. These analyses reveal the disorderly naming conventions of P2P IPTV programs. The analysis results can help to purify and extract useful information from chaotic names for better retrieval and accelerate automatic sorting of program and establishment of IPTV repository. In order to represent popularity of programs and to predict user behavior and popularity of hot programs over a period, we also put forward an analytical model of hot programs. PMID:24772008

  10. Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S.cerevisiae

    PubMed Central

    Marie, Chelsea; Leyde, Sarah; White, Theodore C

    2008-01-01

    Ergosterol homeostasis is a critical process for fungal cells. Paralogous zinc cluster transcription factors Upc2p and Ecm22p are major regulators of ergosterol biosynthesis in Saccharomyces cerevisiae. Upc2p and Ecm22p sense and respond to sterol depletion but their mechanism of activation has not been defined. Subcellular localization and functional expression of Upc2p–GFP and Ecm22p-GFP was monitored by fluorescence microscopy and flow cytometry in live yeast cells. Both fusion proteins localized to intracellular membranes and to perinuclear foci. Perinuclear localization of Upc2p-GFP and Ecm22p-GFP was increased when ergosterol biosynthesis was blocked by azole drug treatment. Nuclear localization in response to sterol depletion is consistent with the hypothesis that Upc2p and Ecm22p are trafficked from a membrane to the nucleus as a post-translational mechanism of sterol sensing. PMID:18675371

  11. The Two Oxidized Forms of the Trinuclear Cu Cluster in the Multicopper Oxidases And Mechanism for the Decay of the Native Intermediate

    SciTech Connect

    Yoon, J.; Liboiron, B.D.; Sarangi, R.; Hodgson, K.O.; Hedman, B.; Solomona, E.I.; /Stanford U., Chem. Dept. /SLAC, SSRL

    2007-10-10

    Multicopper oxidases (MCOs) catalyze the 4e{sup -} reduction of O2 to H2O. The reaction of the fully reduced enzyme with O2 generates the native intermediate (NI), which undergoes a slow decay to the resting enzyme in the absence of substrate. NI is a fully oxidized form, but its spectral features are very different from those of the resting form (also fully oxidized), because the type 2 and the coupled-binuclear type 3 Cu centers in the O2-reducing trinuclear Cu cluster site are isolated in the resting enzyme, whereas these are all bridged by a {mu}3-oxo ligand in NI. Notably, the one azide-bound NI (NI{sub Az}) exhibits spectral features very similar to those of NI, in which the {mu}3-oxo ligand in NI has been replaced by a {mu}3-bridged azide. Comparison of the spectral features of NI and NIAz, combined with density functional theory (DFT) calculations, allows refinement of the NI structure. The decay of NI to the resting enzyme proceeds via successive proton-assisted steps, whereas the rate-limiting step involves structural rearrangement of the {mu}3-oxo-bridge from inside to outside the cluster. This phenomenon is consistent with the slow rate of NI decay that uncouples the resting enzyme from the catalytic cycle, leaving NI as the catalytically relevant fully oxidized form of the MCO active site. The all-bridged structure of NI would facilitate electron transfer to all three Cu centers of the trinuclear cluster for rapid proton-coupled reduction of NI to the fully reduced form for catalytic turnover.

  12. K2P potassium channels, mysterious and paradoxically exciting.

    PubMed

    Goldstein, Steve A N

    2011-08-01

    New evidence reveals that the common electrolyte disorder hypokalemia can induce K2P1 channels that are normally selective for K+ to break the rules and conduct Na+. This defiant behavior leads to paradoxical depolarization of many cells in the heart, increasing the risk for lethal arrhythmia. The new research resolves a mystery uncovered 50 years ago and bestows an array of new riddles. Here, I discuss how K2P1 might achieve this alchemy--through stable residence of the K+ selectivity filter in a Na+-conductive state between its open and C-inactive configurations--and predict that other K+ channels and environmental stimuli will be discovered to produce the same excitatory misconduct. PMID:21868351

  13. Supporting seamless mobility for P2P live streaming.

    PubMed

    Kim, Eunsam; Kim, Sangjin; Lee, Choonhwa

    2014-01-01

    With advent of various mobile devices with powerful networking and computing capabilities, the users' demand to enjoy live video streaming services such as IPTV with mobile devices has been increasing rapidly. However, it is challenging to get over the degradation of service quality due to data loss caused by the handover. Although many handover schemes were proposed at protocol layers below the application layer, they inherently suffer from data loss while the network is being disconnected during the handover. We therefore propose an efficient application-layer handover scheme to support seamless mobility for P2P live streaming. By simulation experiments, we show that the P2P live streaming system with our proposed handover scheme can improve the playback continuity significantly compared to that without our scheme. PMID:24977171

  14. Supporting Seamless Mobility for P2P Live Streaming

    PubMed Central

    Kim, Eunsam; Kim, Sangjin; Lee, Choonhwa

    2014-01-01

    With advent of various mobile devices with powerful networking and computing capabilities, the users' demand to enjoy live video streaming services such as IPTV with mobile devices has been increasing rapidly. However, it is challenging to get over the degradation of service quality due to data loss caused by the handover. Although many handover schemes were proposed at protocol layers below the application layer, they inherently suffer from data loss while the network is being disconnected during the handover. We therefore propose an efficient application-layer handover scheme to support seamless mobility for P2P live streaming. By simulation experiments, we show that the P2P live streaming system with our proposed handover scheme can improve the playback continuity significantly compared to that without our scheme. PMID:24977171

  15. Ring current proton decay by charge exchange

    NASA Technical Reports Server (NTRS)

    Smith, P. H.; Hoffman, R. A.; Fritz, T.

    1975-01-01

    Explorer 45 measurements during the recovery phase of a moderate magnetic storm have confirmed that the charge exchange decay mechanism can account for the decay of the storm-time proton ring current. Data from the moderate magnetic storm of 24 February 1972 was selected for study since a symmetrical ring current had developed and effects due to asymmetric ring current losses could be eliminated. It was found that after the initial rapid decay of the proton flux, the equatorially mirroring protons in the energy range 5 to 30 keV decayed throughout the L-value range of 3.5 to 5.0 at the charge exchange decay rate calculated by Liemohn. After several days of decay, the proton fluxes reached a lower limit where an apparent equilibrium was maintained, between weak particle source mechanisms and the loss mechanisms, until fresh protons were injected into the ring current region during substorms. While other proton loss mechanisms may also be operating, the results indicate that charge exchange can entirely account for the storm-time proton ring current decay, and that this mechanism must be considered in all studies involving the loss of proton ring current particles.

  16. X(3872), IG(JPC) = 0+(1++), as the χc1(2P) charmonium

    NASA Astrophysics Data System (ADS)

    Achasov, N. N.; Rogozina, E. V.

    2015-09-01

    Contrary to almost standard opinion that the X(3872) resonance is the D∗0D¯0 + c.c. molecule or the qcq¯c¯ four-quark state, we discuss the scenario where the X(3872) resonance is the cc¯ = χc1(2P) charmonium which “sits on” the D∗0D¯0 threshold. We explain the shift of the mass of the X(3872) resonance with respect to the prediction of a potential model for the mass of the χc1(2P) charmonium by the contribution of the virtual D∗D¯ + c.c. intermediate states into the self energy of the X(3872) resonance. This allows us to estimate the coupling constant of the X(7872) resonance with the D∗0D¯0 channel, the branching ratio of the X(3872) → D∗0D¯0 + c.c. decay, and the branching ratio of the X(3872) decay into all non-D∗0D¯0 + c.c. states. We predict a significant number of unknown decays of X(3872) via two gluon: X(3872) →gluon gluon →hadrons. We suggest a physically clear program of experimental researches for verification of our assumption.

  17. An Overlapping Structured P2P for REIK Overlay Network

    NASA Astrophysics Data System (ADS)

    Liu, Wenjun; Song, Jingjing; Yu, Jiguo

    REIK is based on a ring which embedded an inverse Kautz digraph, to enable multi-path P2P routing. It has the constant degree and the logarithmic diameter DHT scheme with constant congestion and Byzantine fault tolerance. However, REIK did not consider the interconnection of many independent smaller networks. In this paper, we propose a new approach to build overlay network, OLS-REIK which is an overlapping structured P2P for REIK overlay network. It is a more flexible interconnecting different REIK network. Peers can belong to several rings, allowing this interconnection. By connecting smaller structured overlay networks in an unstructured way, it provides a cost effective alternative to hierarchical structured P2P systems requiring costly merging. Routing of lookup messages is performed as in REIK within one ring, but a peer belonging to several rings forwards the request to the different rings it belongs to. Furthermore a small number of across point is enough to ensure a high exhaustiveness level.

  18. Pure P2P mediation system: A mappings discovery approach

    NASA Astrophysics Data System (ADS)

    selma, El yahyaoui El idrissi; Zellou, Ahmed; Idri, Ali

    2015-02-01

    The information integration systems consist in offering a uniform interface to provide access to a set of autonomous and distributed information sources. The most important advantage of this system is that it allows users to specify what they want, rather than thinking about how to get the responses. The works realized in this area have particular leads to two major classes of integration systems: the mediation systems based on the paradigm mediator / adapter and peer to peer systems (P2P). The combination of both systems has led to a third type; is the mediation P2P systems. The P2P systems are large-scale systems, self-organized and distributed. They allow the resource management in a completely decentralized way. However, the integration of structured information sources, heterogeneous and distributed proves to be a complex problem. The objective of this work is to propose an approach to resolve conflicts and establish a mapping between the heterogeneous elements. This approach is based on clustering; the latter is to group similar Peers that share common information in the same subnet. Thus, to facilitate the heterogeneity, we introduced three additional layers of our hierarchy of peers: internal schema, external schema and Schema directory peer. We used linguistic techniques, and precisely the name correspondence technique, that is based on the similarity of names to propose a correspondence.

  19. Load Balancing in Structured P2P Networks

    NASA Astrophysics Data System (ADS)

    Zhu, Yingwu

    In this chapter we start by addressing the importance and necessity of load balancing in structured P2P networks, due to three main reasons. First, structured P2P networks assume uniform peer capacities while peer capacities are heterogeneous in deployed P2P networks. Second, resorting to pseudo-uniformity of the hash function used to generate node IDs and data item keys leads to imbalanced overlay address space and item distribution. Lastly, placement of data items cannot be randomized in some applications (e.g., range searching). We then present an overview of load aggregation and dissemination techniques that are required by many load balancing algorithms. Two techniques are discussed including tree structure-based approach and gossip-based approach. They make different tradeoffs between estimate/aggregate accuracy and failure resilience. To address the issue of load imbalance, three main solutions are described: virtual server-based approach, power of two choices, and address-space and item balancing. While different in their designs, they all aim to improve balance on the address space and data item distribution. As a case study, the chapter discusses a virtual server-based load balancing algorithm that strives to ensure fair load distribution among nodes and minimize load balancing cost in bandwidth. Finally, the chapter concludes with future research and a summary.

  20. Interatomic Coulombic decay following Ne 1s Auger decay in NeAr

    SciTech Connect

    Ouchi, T.; Sakai, K.; Fukuzawa, H.; Ueda, K.; Higuchi, I.; Tamenori, Y.; Demekhin, Ph. V.; Chiang, Y.-C.; Stoychev, S. D.; Kuleff, A. I.; Mazza, T.; Schoeffler, M.; Nagaya, K.; Yao, M.; Saito, N.

    2011-05-15

    Using momentum-resolved electron-ion multicoincidence spectroscopy, we have investigated interatomic Coulombic decay (ICD) in the heteronuclear NeAr dimer following Ne 1s Auger decay. The measured intensity ratio for the three ICD transitions Ne{sup 2+}(2s{sup -1}2p{sup -1} {sup 1}P)Ar to Ne{sup 2+}(2p{sup -2} {sup 1}S)-Ar{sup +}(3p{sup -1}), Ne{sup 2+}(2s{sup -1}2p{sup -1} {sup 1}P)Ar to Ne{sup 2+}(2p{sup -2} {sup 1}D)-Ar{sup +}(3p{sup -1}), and Ne{sup 2+}(2s{sup -1}2p{sup -1} {sup 3}P)Ar to Ne{sup 2+}(2p{sup -2} {sup 3}P)-Ar{sup +}(3p{sup -1}) reasonably agree with predictions. The kinetic energy release distribution for the fragmentation to Ne{sup 2+}(2p{sup -2} {sup 1}D)-Ar{sup +}(3p{sup -1}) after the ICD transition from singlet Ne{sup 2+}(2s{sup -1}2p{sup -1} {sup 1}P)Ar state, which is a mirror image of the kinetic energy distribution of the emitted ICD electrons, suggests that the corresponding ICD rate is roughly two times lower than predicted by ab initio calculations.

  1. Stick slip, charge separation and decay

    USGS Publications Warehouse

    Lockner, D.A.; Byerlee, J.D.; Kuksenko, V.S.; Ponomarev, A.V.

    1986-01-01

    Measurements of charge separation in rock during stable and unstable deformation give unexpectedly large decay times of 50 sec. Time-domain induced polarization experiments on wet and dry rocks give similar decay times and suggest that the same decay mechanisms operate in the induced polarization response as in the relaxation of charge generated by mechanical deformation. These large decay times are attributed to electrochemical processes in the rocks, and they require low-frequency relative permittivity to be very large, in excess of 105. One consequence of large permittivity, and therefore long decay times, is that a significant portion of any electrical charge generated during an earthquake can persist for tens or hundreds of seconds. As a result, electrical disturbances associated with earthquakes should be observable for these lengths of time rather than for the milliseconds previously suggested. ?? 1986 Birka??user Verlag.

  2. Inverse seesaw mechanism, leptogenesis, observable proton decay, and {Delta}{sub R}{sup {+-}{+-}} in supersymmetric SO(10) with heavy W{sub R}

    SciTech Connect

    Parida, Mina K.; Raychaudhuri, Amitava

    2010-11-01

    We explore the prospects of low-scale leptogenesis in a class of supersymmetric SO(10) models using extra singlet neutrinos (T{sub i}, i=1, 2, 3) and the Higgs representations 126{sub H}+ 126{sub H} as well as 16{sub H}+16{sub H}. A singlet neutrino, which we show can be as light as 10{sup 5}-10{sup 6} GeV, decays through its small mixings with right-handed (RH) neutrinos creating a lepton asymmetry which is explicitly shown to be flavor dependent. While the doublet vacuum expectation value in 16{sub H} triggers the generation of desired mixings, it also induces a large RH-triplet vacuum expectation value that breaks the left-right intermediate gauge symmetry and gives large right-handed neutrino masses. Manifest unification of gauge couplings and generation of heavy RH neutrino masses are achieved by purely renormalizable interactions. The canonical (Type-I) seesaw contributions to the light neutrino mass matrix cancel out while the Type-II seesaw contribution is negligible. Determining the parameters of the dominant inverse seesaw formula by using the underlying quark-lepton symmetry and neutrino oscillation data, we show how leptogenesis under the gravitino constraint is successfully implemented. New formulas for the decay rate and the asymmetry parameter are derived leading to baryon asymmetry within the observed range without invoking a resonant condition on RH neutrinos. The model is found to work for hierarchical as well as inverted hierarchical light neutrino masses. Testable predictions of the model are RH doubly charged Higgs bosons which may be leptophilic and accessible to the Tevatron, LHC or a linear collider. In a model-independent manner, the Drell-Yan pair production cross section at the Tevatron or LHC is shown to be bounded between 59%-79% of their left-handed counterparts with same mass. In contrast to single-step breaking supersymmetric grand unified theories, which predict a long proton lifetime for the decay p{yields}e{sup +{pi}0}, here this

  3. Widely available active sites on Ni2P for electrochemical hydrogen evolution--insights from first principles calculations.

    PubMed

    Hansen, Martin H; Stern, Lucas-Alexandre; Feng, Ligang; Rossmeisl, Jan; Hu, Xile

    2015-04-28

    We present insights into the mechanism and the active site for hydrogen evolution on nickel phosphide (Ni2P). Ni2P was recently discovered to be a very active non-precious hydrogen evolution catalyst. Current literature attributes the activity of Ni2P to a particular site on the (0001) facet. In the present study, using Density Functional Theory (DFT) calculations, we show that several widely available low index crystal facets on Ni2P have better properties for a high catalytic activity. DFT calculations were used to identify moderately bonding nickel bridge sites and nickel hollow sites for hydrogen adsorption and to calculate barriers for the Tafel pathway. The investigated surfaces in this study were the (101̅0), (1̅1̅20), (112̅0), (112̅1) and (0001) facets of the hexagonal Ni2P crystal. In addition to the DFT results, we present experiments on Ni2P nanowires growing along the 〈0001〉 direction, which are shown as efficient hydrogen evolution catalysts. The experimental results add these nanowires to a variety of different morphologies of Ni2P, which are all active for HER. PMID:25812670

  4. Uncovering the behavior of Hf2Te2P and the candidate Dirac metal Zr2Te2P

    NASA Astrophysics Data System (ADS)

    Chen, K.-W.; Das, S.; Rhodes, D.; Memaran, S.; Besara, T.; Siegrist, T.; Manousakis, E.; Balicas, L.; Baumbach, R. E.

    2016-04-01

    Results are reported for single crystal specimens of Hf2Te2P and compared to its structural analogue Zr2Te2P, which was recently proposed to be a potential reservoir for Dirac physics [1]. Both materials are produced using the iodine vapor phase transport method and the resulting crystals are exfoliable. The bulk electrical transport and thermodynamic properties indicate Fermi liquid behavior at low temperature for both compounds. Quantum oscillations are observed in magnetization measurements for fields applied parallel but not perpendicular to the c-axis, suggesting that the Fermi surfaces are quasi-two dimensional. Frequencies are determined from quantum oscillations for several parts of the Fermi surfaces. Lifshitz-Kosevich fits to the temperature dependent amplitudes of the oscillations reveal small effective masses, with a particularly small value {{m}\\ast}=0.046{{m}0} for the α branch of Zr2Te2P. Electronic structure calculations are in good agreement with quantum oscillation results and illustrate the effect of a stronger spin-orbit interaction going from Zr to Hf. These results suggest that by using appropriate tuning parameters this class of materials may deepen the pool of novel Dirac phenomena.

  5. Uncovering the behavior of Hf2Te2P and the candidate Dirac metal Zr2Te2P.

    PubMed

    Chen, K-W; Das, S; Rhodes, D; Memaran, S; Besara, T; Siegrist, T; Manousakis, E; Balicas, L; Baumbach, R E

    2016-04-13

    Results are reported for single crystal specimens of Hf2Te2P and compared to its structural analogue Zr2Te2P, which was recently proposed to be a potential reservoir for Dirac physics [1]. Both materials are produced using the iodine vapor phase transport method and the resulting crystals are exfoliable. The bulk electrical transport and thermodynamic properties indicate Fermi liquid behavior at low temperature for both compounds. Quantum oscillations are observed in magnetization measurements for fields applied parallel but not perpendicular to the c-axis, suggesting that the Fermi surfaces are quasi-two dimensional. Frequencies are determined from quantum oscillations for several parts of the Fermi surfaces. Lifshitz-Kosevich fits to the temperature dependent amplitudes of the oscillations reveal small effective masses, with a particularly small value [Formula: see text] for the α branch of Zr2Te2P. Electronic structure calculations are in good agreement with quantum oscillation results and illustrate the effect of a stronger spin-orbit interaction going from Zr to Hf. These results suggest that by using appropriate tuning parameters this class of materials may deepen the pool of novel Dirac phenomena. PMID:26953683

  6. The decay rates of autoionizing quasi-molecular states

    NASA Astrophysics Data System (ADS)

    Kishinevsky, L. M.; Krakov, B. G.; Parilis, E. S.

    1981-09-01

    The decay rates of three quasi-molecular autoionizing states of a HeBe 4+-like system consisting of two electrons and two Coulomb centres are calculated. It is shown that with decreasing internuclear distance the decay rate passes through a maximum which for (2 pσ) 2 states is 1.6 × 10 15s-1. This considerably exceeds the value for the united atom.

  7. Moduli Decays and Gravitinos

    SciTech Connect

    Dine, Michael; Kitano, Ryuichiro; Morisse, Alexander; Shirman, Yuri

    2006-04-21

    One proposed solution of the moduli problem of string cosmology requires that the moduli are quite heavy, their decays reheating the universe to temperatures above the scale of nucleosynthesis. In many of these scenarios, the moduli are approximately supersymmetric; it is then crucial that the decays to gravitinos are helicity suppressed. In this paper, we discuss situations where these decays are, and are not, suppressed. We also comment on a possible gravitino problem from inaton decay.

  8. Baryonic B Decays

    NASA Astrophysics Data System (ADS)

    Chistov, R.

    2016-02-01

    In this talk the decays of B-mesons into baryons are discussed. Large mass of B-meson makes possible the decays of the type B → baryon (+mesons). Experimental observations and measurements of these decays at B-factories Belle and BaBar have stimulate the development of theoretical models in this field. We briefly review the experimental results together with the current theoretical models which describe baryonic B decays.

  9. Effects of Neutrino Decay on Oscillation Probabilities

    NASA Astrophysics Data System (ADS)

    Leonard, Kayla; de Gouvêa, André

    2016-01-01

    It is now well accepted that neutrinos oscillate as a quantum mechanical result of a misalignment between their mass-eigenstates and the flavor-eigenstates. We study neutrino decay—the idea that there may be new, light states that the three Standard Model flavors may be able to decay into. We consider what effects this neutrino decay would have on the observed oscillation probabilities.The Hamiltonian governs how the states change with time, so we use it to calculate an oscillation amplitude, and from that, the oscillation probability. We simplify the theoretical probabilities using results from experimental data, such as the neutrino mixing angles and mass differences. By exploring what values of the decay parameters are physically allowable, we can begin to understand just how large the decay parameters can be. We compare the probabilities in the case of no neutrino decay and in the case of maximum neutrino decay to determine how much of an effect neutrino decay could have on observations, and discuss the ability of future experiments to detect these differences.We also examine neutrino decay in the realm of CP invariance, and found that it is a new source of CP violation. Our work indicates that there is a difference in the oscillation probabilities between particle transitions and their corresponding antiparticle transitions. If neutrino decay were proven true, it could be an important factor in understanding leptogenesis and the particle-antiparticle asymmetry present in our Universe.

  10. Precision lifetime measurements of the 2p levels in lithium

    SciTech Connect

    Berry, H.G.; Kurtz, C.; Tanner, C.E.

    1995-08-01

    These measurements are motivated by the theoretical challenges posed by lithium. The three-electron lithium atom is one of the simplest atomic systems with which to test atomic structure calculations. Recently, there were several ab initio calculations of the lithium 2s-2p oscillator strengths, which agree to 0.15%. However, the theoretical results differ by 5 sigma from the precise fast-beam-laser lifetime measurement of Gaupp and Andra (Berlin). Hence the need for a new independent and precise measurement. Improvements were added to the fast beam laser techniques developed for cesium in order to measure the lithium 2p state lifetime. Although the technique is similar to that of cesium, the lithium atom presents a few new complications. Since the atom is lighter, it travels more quickly through the interaction and detection regions. Therefore, the 670 nm wavelength requires a dye laser to produce sufficient intensity to populate the excited state. Unfortunately, the intensity of the dye laser is inherently less stable than that of a diode laser. Another complication is that the ion-beam intensity is much more sensitive to fluctuations in the accelerating voltage. Two detectors were added: one to monitor the ion-beam intensity, and the other to monitor the laser power. With the information from the additional detectors, a new data analysis scheme was developed. Sufficient data were taken to evaluate the benefits of the new detectors. No additional work is planned at Argonne for this experiment.

  11. β -Decay Half-Lives of 110 Neutron-Rich Nuclei across the N =82 Shell Gap: Implications for the Mechanism and Universality of the Astrophysical r Process

    NASA Astrophysics Data System (ADS)

    Lorusso, G.; Nishimura, S.; Xu, Z. Y.; Jungclaus, A.; Shimizu, Y.; Simpson, G. S.; Söderström, P.-A.; Watanabe, H.; Browne, F.; Doornenbal, P.; Gey, G.; Jung, H. S.; Meyer, B.; Sumikama, T.; Taprogge, J.; Vajta, Zs.; Wu, J.; Baba, H.; Benzoni, G.; Chae, K. Y.; Crespi, F. C. L.; Fukuda, N.; Gernhäuser, R.; Inabe, N.; Isobe, T.; Kajino, T.; Kameda, D.; Kim, G. D.; Kim, Y.-K.; Kojouharov, I.; Kondev, F. G.; Kubo, T.; Kurz, N.; Kwon, Y. K.; Lane, G. J.; Li, Z.; Montaner-Pizá, A.; Moschner, K.; Naqvi, F.; Niikura, M.; Nishibata, H.; Odahara, A.; Orlandi, R.; Patel, Z.; Podolyák, Zs.; Sakurai, H.; Schaffner, H.; Schury, P.; Shibagaki, S.; Steiger, K.; Suzuki, H.; Takeda, H.; Wendt, A.; Yagi, A.; Yoshinaga, K.

    2015-05-01

    The β -decay half-lives of 110 neutron-rich isotopes of the elements from Rb 37 to Sn 50 were measured at the Radioactive Isotope Beam Factory. The 40 new half-lives follow robust systematics and highlight the persistence of shell effects. The new data have direct implications for r -process calculations and reinforce the notion that the second (A ≈130 ) and the rare-earth-element (A ≈160 ) abundance peaks may result from the freeze-out of an (n ,γ )⇄(γ ,n ) equilibrium. In such an equilibrium, the new half-lives are important factors determining the abundance of rare-earth elements, and allow for a more reliable discussion of the r process universality. It is anticipated that universality may not extend to the elements Sn, Sb, I, and Cs, making the detection of these elements in metal-poor stars of the utmost importance to determine the exact conditions of individual r -process events.

  12. Radioactive decays of highly-charged ions

    NASA Astrophysics Data System (ADS)

    Gao, B. S.; Najafi, M. A.; Atanasov, D. R.; Blaum, K.; Bosch, F.; Brandau, C.; Chen, X. C.; Dillmann, I.; Dimopoulou, Ch.; Faestermann, Th.; Geissel, H.; Gernhäuser, R.; Hillenbrand, P.-M.; Kovalenko, O.; Kozhuharov, C.; Litvinov, S. A.; Litvinov, Yu. A.; Maier, L.; Nolden, F.; Piotrowski, J.; Sanjari, M. S.; Scheidenberger, C.; Spillmann, U.; Steck, M.; Stöhlker, Th.; Trageser, Ch.; Tu, X. L.; Weick, H.; Winckler, N.; Xu, H. S.; Yamaguchi, T.; Yan, X. L.; Zhang, Y. H.; Zhou, X. H.

    2015-05-01

    Access to stored and cooled highly-charged radionuclides offers unprecedented opportunities to perform high-precision investigations of their decays. Since the few-electron ions, e.g. hydrogen- or helium-like ions, are quantum mechanical systems with clear electronic ground state configurations, the decay studies of such ions are performed under well-defined conditions and allow for addressing fundamental aspects of the decay process. Presented here is a compact review of the relevant experiments conducted at the Experimental Storage Ring ESR of GSI. A particular emphasis is given to the investigations of the two-body beta decay, namely the bound-state β-decay and its time-mirrored counterpart, orbital electron-capture.

  13. Pip2p: a transcriptional regulator of peroxisome proliferation in the yeast Saccharomyces cerevisiae.

    PubMed Central

    Rottensteiner, H; Kal, A J; Filipits, M; Binder, M; Hamilton, B; Tabak, H F; Ruis, H

    1996-01-01

    In Saccharomyces cerevisiae, peroxisomes are the exclusive site for the degradation of fatty acids. Upon growth with the fatty acid oleic acid as sole carbon source, not only are the enzymes of beta-oxidation and catalase A induced, but also the peroxisomal compartment as a whole increases in volume and the number of organelles per cell rises. We previously identified a cis-acting DNA sequence [oleate response element (ORE)] involved in induction of genes encoding peroxisomal proteins. The aim of our investigation was to test whether a single mechanism acting via the ORE coordinates the events necessary for the proliferation of an entire organelle. Here we report the cloning and characterization of the oleate-specific transcriptional activator protein Pip2p (pip: peroxisome induction pathway). Pip2p contains a typical Zn(2)-Cys(6) cluster domain and binds to OREs. A pip2 deletion strain is impaired in growth on oleate as sole carbon source and the induction of beta-oxidation enzymes is abolished. Moreover, only a few, small peroxisomes per cell can be detected. These results indicate that fatty acids activate Pip2p, which in turn activates the transcription of genes encoding beta-oxidation components and acts as the crucial activator of peroxisomes. Images PMID:8670793

  14. Structural, elastic, electronic and optical properties of new layered semiconductor BaGa2P2

    NASA Astrophysics Data System (ADS)

    Bouhemadou, A.; Khenata, R.; Bin-Omran, S.; Murtaza, G.; Al-Douri, Y.

    2015-08-01

    We report the results of a detailed first-principles based density functional theory study of the structural, elastic, electronic and optical properties of a recently synthesized layered semiconductor BaGa2P2. The optimized structural parameters are in excellent agreement with the experimental structural findings, which validates the used theoretical method. The single crystal and polycrystalline elastic constants are numerically estimated using the strain-stress method and Voigt-Reuss-Hill approximations. Predicted values of the elastic constants suggest that the considered material is mechanically stable, brittle and very soft material. The three-dimensional surface and its planar projections of Young's modulus are visualized to illustrate the elastic anisotropy. It is found that Young's modulus of BaGa2P2 show strong dependence on the crystallographic directions. Band structure calculation reveals that BaGa2P2 is a direct energy band gap semiconductor. The effective masses of electrons and holes at the minimum of the conduction band and maximum of the valence band are numerically estimated. The density of state, charge density distribution and charge transfers are calculated and analyzed to determine the chemical bonding nature. Dielectric function, refractive index, extinction coefficient, absorption coefficient, reflectivity and electron-loss energy function spectra are computed for a wide photon energy range up to 20 eV. Calculated optical spectra exhibit a noticeable anisotropy.

  15. P2P Approach for Web Services Publishing and Discovery

    NASA Astrophysics Data System (ADS)

    Islam, Mohmammad Towhidul; Akon, Mursalin; Shen, Xuemin (Sherman)

    Web service is an emerging paradigm for distributing business applications from different platforms to a wide variety of clients. The critical factor in seamlessly accessing web services is to discover the appropriate service and the related service providers. Unfortunately, current web service technologies use centralized directory to keep the service index, which is not scalable and at the same time vulnerable to single point of failure. Peer to peer system is a popular decentralized architecture which can be used for key look up service with scalability and self organization. Thus there is an opportunity to intersect the P2P framework with web services to provide the scalable solution. In this chapter, we discuss the key methods to deploy web services using the peer-to-peer technology.

  16. Genomewide analysis of polysaccharides degrading enzymes in 11 white- and brown-rot Polyporales provides insight into mechanisms of wood decay.

    PubMed

    Hori, Chiaki; Gaskell, Jill; Igarashi, Kiyohiko; Samejima, Masahiro; Hibbett, David; Henrissat, Bernard; Cullen, Dan

    2013-01-01

    To degrade the polysaccharides, wood-decay fungi secrete a variety of glycoside hydrolases (GHs) and carbohydrate esterases (CEs) classified into various sequence-based families of carbohydrate-active enzymes (CAZys) and their appended carbohydrate-binding modules (CBM). Oxidative enzymes, such as cellobiose dehydrogenase (CDH) and lytic polysaccharide monooxygenase (LPMO, formerly GH61), also have been implicated in cellulose degradation. To examine polysaccharide-degrading potential between white- and brown-rot fungi, we performed genomewide analysis of CAZys and these oxidative enzymes in 11 Polyporales, including recently sequenced monokaryotic strains of Bjerkandera adusta, Ganoderma sp. and Phlebia brevispora. Furthermore, we conducted comparative secretome analysis of seven Polyporales grown on wood culture. As a result, it was found that genes encoding cellulases belonging to families GH6, GH7, GH9 and carbohydrate-binding module family CBM1 are lacking in genomes of brown-rot polyporales. In addition, the presence of CDH and the expansion of LPMO were observed only in white-rot genomes. Indeed, GH6, GH7, CDH and LPMO peptides were identified only in white-rot polypores. Genes encoding aldose 1-epimerase (ALE), previously detected with CDH and cellulases in the culture filtrates, also were identified in white-rot genomes, suggesting a physiological connection between ALE, CDH, cellulase and possibly LPMO. For hemicellulose degradation, genes and peptides corresponding to GH74 xyloglucanase, GH10 endo-xylanase, GH79 β-glucuronidase, CE1 acetyl xylan esterase and CE15 glucuronoyl methylesterase were significantly increased in white-rot genomes compared to brown-rot genomes. Overall, relative to brown-rot Polyporales, white-rot Polyporales maintain greater enzymatic diversity supporting lignocellulose attack. PMID:23935027

  17. Inclusive and exclusive measurements of B decays to χc 1 and χc 2 at Belle

    NASA Astrophysics Data System (ADS)

    Bhardwaj, V.; Miyabayashi, K.; Panzenböck, E.; Trabelsi, K.; Frey, A.; Abdesselam, A.; Adachi, I.; Aihara, H.; Al Said, S.; Arinstein, K.; Asner, D. M.; Atmacan, H.; Aulchenko, V.; Aushev, T.; Ayad, R.; Babu, V.; Badhrees, I.; Bahinipati, S.; Bakich, A. M.; Bala, A.; Bansal, V.; Barberio, E.; Bhuyan, B.; Biswal, J.; Bobrov, A.; Bondar, A.; Bozek, A.; Bračko, M.; Browder, T. E.; Červenkov, D.; Chekelian, V.; Chen, A.; Cheon, B. G.; Chilikin, K.; Chistov, R.; Cho, K.; Chobanova, V.; Choi, S.-K.; Choi, Y.; Cinabro, D.; Dalseno, J.; Danilov, M.; Doležal, Z.; Dutta, D.; Eidelman, S.; Farhat, H.; Fast, J. E.; Ferber, T.; Frost, O.; Fulsom, B. G.; Gaur, V.; Gabyshev, N.; Ganguly, S.; Garmash, A.; Gillard, R.; Glattauer, R.; Goh, Y. M.; Goldenzweig, P.; Golob, B.; Greenwald, D.; Haba, J.; Hamer, P.; Hayasaka, K.; Hayashii, H.; He, X. H.; Hou, W.-S.; Iijima, T.; Inami, K.; Ishikawa, A.; Itoh, R.; Iwasaki, Y.; Jaegle, I.; Joffe, D.; Joo, K. K.; Julius, T.; Kato, E.; Katrenko, P.; Kawasaki, T.; Kiesling, C.; Kim, D. Y.; Kim, J. B.; Kim, K. T.; Kim, M. J.; Kim, S. H.; Kim, Y. J.; Kinoshita, K.; Ko, B. R.; Kobayashi, N.; Kodyš, P.; Korpar, S.; Križan, P.; Krokovny, P.; Kuhr, T.; Kumar, R.; Kumita, T.; Kuzmin, A.; Kwon, Y.-J.; Lee, I. S.; Li, C.; Li, Y.; Li Gioi, L.; Libby, J.; Liventsev, D.; Loos, A.; Lukin, P.; Masuda, M.; Matvienko, D.; Miyata, H.; Mizuk, R.; Mohanty, G. B.; Mohanty, S.; Moll, A.; Moon, H. K.; Mussa, R.; Nakano, E.; Nakao, M.; Nanut, T.; Natkaniec, Z.; Nayak, M.; Nisar, N. K.; Nishida, S.; Ogawa, S.; Okuno, S.; Pakhlova, G.; Pal, B.; Park, C. W.; Park, H.; Pedlar, T. K.; Pestotnik, R.; Petrič, M.; Piilonen, L. E.; Pulvermacher, C.; Purohit, M. V.; Rauch, J.; Ribežl, E.; Ritter, M.; Rostomyan, A.; Sahoo, H.; Sakai, Y.; Sandilya, S.; Santelj, L.; Sanuki, T.; Sato, Y.; Savinov, V.; Schneider, O.; Schnell, G.; Schwanda, C.; Seino, Y.; Semmler, D.; Senyo, K.; Seon, O.; Sevior, M. E.; Shebalin, V.; Shen, C. P.; Shibata, T.-A.; Shiu, J.-G.; Shwartz, B.; Simon, F.; Singh, J. B.; Sohn, Y.-S.; Sokolov, A.; Solovieva, E.; Starič, M.; Stypula, J.; Sumihama, M.; Sumiyoshi, T.; Tamponi, U.; Tanida, K.; Teramoto, Y.; Uchida, M.; Uehara, S.; Uglov, T.; Unno, Y.; Uno, S.; Urquijo, P.; Usov, Y.; Van Hulse, C.; Vanhoefer, P.; Varner, G.; Vinokurova, A.; Vorobyev, V.; Wang, C. H.; Wang, M.-Z.; Wang, P.; Wang, X. L.; Watanabe, M.; Watanabe, Y.; Wehle, S.; Won, E.; Yamaoka, J.; Yashchenko, S.; Ye, H.; Yook, Y.; Yuan, C. Z.; Yusa, Y.; Zhang, Z. P.; Zhilich, V.; Zhulanov, V.; Zupanc, A.; Belle Collaboration

    2016-03-01

    We report inclusive and exclusive measurements for χc 1 and χc 2 production in B decays. We measure B (B →χc 1X )=(3.03 ±0.05 (stat )±0.24 (syst ))×10-3 and B (B →χc 2X )=(0.70 ±0.06 (stat )±0.10 (syst ))×10-3 . For the first time, χc 2 production in exclusive B decays in the modes B0→χc 2π-K+ and B+→χc 2π+π-K+ has been observed, along with first evidence for the B+→χc 2π+KS0 decay mode. For χc 1 production, we report the first observation in the B+→χc 1π+π-K+ , B0→χc 1π+π-KS0 and B0→χc 1π0π-K+ decay modes. Using these decay modes, we observe a difference in the production mechanism of χc 2 in comparison to χc 1 in B decays. In addition, we report searches for X (3872 ) and χc 1(2 P ) in the B+→(χc 1π+π-)K+ decay mode. The reported results use 772 ×106 B B ¯ events collected at the ϒ (4 S ) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider.

  18. MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63

    PubMed Central

    Gamble, Laura D.; Kees, Ursula R.; Tweddle, Deborah A.; Lunec, John

    2011-01-01

    MYCN amplification is a major biomarker of poor prognosis, occurring in 25-30% of neuroblastomas. MYCN plays contradictory roles in promoting cell growth and sensitizing cells to apoptosis. We have recently shown that p53 is a direct transcriptional target of MYCN in neuroblastoma and that p53-mediated apoptosis may be an important mechanism of MYCN-induced apoptosis. Although p53 mutations are rare in neuroblastoma at diagnosis, the p53/MDM2/p14ARF pathway is often inactivated through MDM2 amplification or p14ARF inactivation. We hypothesised that reactivation of p53 by inhibition of its negative regulator MDM2, using the MDM2-p53 antagonists Nutlin-3 and MI-63, will result in p53-mediated growth arrest and apoptosis especially in MYCN amplified cells. Using the SHEP Tet21N MYCN regulatable system, MYCN(−) cells were more resistant to both Nutlin-3 and MI-63 mediated growth inhibition and apoptosis compared to MYCN(+) cells and siRNA mediated knockdown of MYCN in 4 MYCN amplified cell lines resulted in decreased p53 expression and activation, as well as decreased levels of apoptosis following treatment with MDM2-p53 antagonists. In a panel of 18 neuroblastoma cell lines treated with Nutlin-3 and MI-63, the sub-set amplified for MYCN had a significantly lower mean GI50 value and increased caspase 3/7 activity compared to the non MYCN amplified group of cell lines, but p53 mutant cell lines were resistant to the antagonists regardless of MYCN status. We conclude that amplification or overexpression of MYCN sensitizes neuroblastoma cell lines with wildtype p53 to MDM2-p53 antagonists and that these compounds may therefore be particularly effective in treating high risk MYCN amplified disease. PMID:21725357

  19. CCQE, 2p2h excitations and ν—energy reconstruction

    SciTech Connect

    Nieves, J.; Simo, I. Ruiz; Sánchez, F.; Vacas, M. J. Vicente

    2015-05-15

    We analyze the MiniBooNE muon neutrino CCQE-like dσ/dT{sub μ} d cos θ{sub μ} data using a theoretical model that, among other nuclear effects, includes RPA correlations and 2p2h (multinucleon) mechanisms. These corrections turn out to be essential for the description of the data. We find that MiniBooNE CCQE-like data are fully compatible with former determinations of the nucleon axial mass M{sub A} ∼ 1.05 GeV. This is in sharp contrast with several previous analysis where anomalously large values of M{sub A} ∼ 1.4 GeV have been suggested. We also show that because of the the multinucleon mechanism effects, the algorithm used to reconstruct the neutrino energy is not adequate when dealing with quasielastic-like events. Finally, we analyze the MiniBooNE unfolded cross section, and show that it exhibits an excess (deficit) of low (high) energy neutrinos, which is an artifact of the unfolding process that ignores 2p2h mechanisms.

  20. Two new de novo interstitial duplications covering 2p14-p22.1: clinical and molecular analysis.

    PubMed

    Kasnauskiene, J; Cimbalistiene, L; Utkus, A; Ciuladaite, Z; Preiksaitiene, E; Pečiulytė, A; Kučinskas, V

    2013-01-01

    We provide a detailed clinical and molecular analysis of 2 patients with de novo interstitial duplications at 2p14-p16.1 and 2p16.1-p22.1. The 10.13-Mb duplication of chromosome 2p14-p16.1 was identified in a 9-year-old boy with mental retardation, behavioral problems (hyperactivity, hyperphagia, and subsequent vomiting), recurrent respiratory tract infections, macrocephaly, epilepsy, and dysmorphic features. The 17.49-Mb duplication of 2p16.1-p22.1 was found in a 17-year-old girl with moderate mental retardation, behavioral and emotional problems, anxiety, and facial dysmorphic features. Very few cases of de novo interstitial duplication of 2p14-p22.1 are reported in the literature, with the great majority of them lacking a detailed molecular analysis. The abnormal phenotype of these cases is caused by mechanisms such as the overdose of a duplicated gene (or genes), the disruption of a gene or its regulatory sequence by the breakpoints of duplication, or by an excess of genetic material which may disorganize chromatin conformation affecting distant gene expression. The clinical and molecular analysis of these 2 rare de novo interstitial duplications provides useful information which is extremely valuable for clinical evaluation at the prenatal and postnatal level and for the molecular understanding of the underlying mechanisms of human diseases. PMID:23036992

  1. Preliminary Evaluation of the Thermally Affected Metallurgical Condition of Extruded and Drawn CuFe2P Tubes

    NASA Astrophysics Data System (ADS)

    Pantazopoulos, George; Toulfatzis, Anagnostis; Zormalia, Sylvia; Vazdirvanidis, Athanasios; Skarmoutsos, Dionysios

    2012-10-01

    The influence of heat treatment conditions on the mechanical behavior and microstructure of CuFe2P (ASTM C19400) in comparison to deoxidized-high-phosphorus (DHP-Cu/ASTM C12200) tubes was investigated. The aim of this study was the enhancement of understanding of microstructure/thermal treatment/strength relationships which could be further utilized for the manufacturing of components exhibiting superior performance and reliability for refrigeration and heat exchanger applications. Microstructural examination employing optical metallography and scanning electron microscopy is used for the evaluation of the recrystallization progress and grain growth processes. In addition, tensile testing was conducted to CuFe2P and DHP tubes following the application of heat treatment cycles, in accordance to the EN 10002-1 specifications. Mechanical properties and microstructure evaluation showed that CuFe2P material is fully recrystallized at 740 °C and DHP at 400 °C for 20 min. Recrystallization initiation varies within the range of 640-660 °C for CuFe2P and below 400 °C for DHP tubes. The tensile strength of the CuFe2P tube decreased from 513 to 367 MPa, the hardness was reduced from 144 to 126 HV, while tensile elongation was significantly improved from 3 to 17%. At 640 °C, only isolated recrystallized areas were evident mainly at the Fe-based intermetallic particle/copper matrix interface areas.

  2. Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction

    PubMed Central

    Thayer, Kelly M.; Beyer, George A.

    2016-01-01

    The ubiquitin ligase MDM2, a principle regulator of the tumor suppressor p53, plays an integral role in regulating cellular levels of p53 and thus a prominent role in current cancer research. Computational analysis used MUMBO to rotamerize the MDM2-p53 crystal structure 1YCR to obtain an exhaustive search of point mutations, resulting in the calculation of the ΔΔG comprehensive energy landscape for the p53-bound regulator. The results herein have revealed a set of residues R65-E69 on MDM2 proximal to the p53 hydrophobic binding pocket that exhibited an energetic profile deviating significantly from similar residues elsewhere in the protein. In light of the continued search for novel competitive inhibitors for MDM2, we discuss possible implications of our findings on the drug discovery field. PMID:26992014

  3. Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction.

    PubMed

    Thayer, Kelly M; Beyer, George A

    2016-01-01

    The ubiquitin ligase MDM2, a principle regulator of the tumor suppressor p53, plays an integral role in regulating cellular levels of p53 and thus a prominent role in current cancer research. Computational analysis used MUMBO to rotamerize the MDM2-p53 crystal structure 1YCR to obtain an exhaustive search of point mutations, resulting in the calculation of the ΔΔG comprehensive energy landscape for the p53-bound regulator. The results herein have revealed a set of residues R65-E69 on MDM2 proximal to the p53 hydrophobic binding pocket that exhibited an energetic profile deviating significantly from similar residues elsewhere in the protein. In light of the continued search for novel competitive inhibitors for MDM2, we discuss possible implications of our findings on the drug discovery field. PMID:26992014

  4. {psi}'' Decays to charmless final states

    SciTech Connect

    Rosner, Jonathan L. . E-mail: rosner@hep.uchicago.edu

    2005-09-01

    The importance of measuring the non-DD-bar decays of the {psi}''={psi}(3770) resonance is discussed. These decays can shed light on a possible discrepancy between the total and DD-bar cross-sections at the {psi}'', and on a proposed mechanism for enhancement of penguin amplitudes in B meson decays through charm-anticharm annihilation. Measurements (including the {psi}'' line shape) in states of definite G-parity and in inclusive charmless final states such as {eta}'+X are found to be particularly important.

  5. Axions from string decay

    SciTech Connect

    Hagmann, C., LLNL

    1998-07-09

    We have studied numerically the evolution and decay of axion strings. These global defects decay mainly by axion emission and thus contribute to the cosmological axion energy density. The relative importance of this source relative to misalignment production of axions depends on the spectrum. Radiation spectra for various string loop configurations are presented. They support the contention that the string decay contribution is of the same order of magnitude as the contribution from misalignment.

  6. Ternary complex formation of Ino2p-Ino4p transcription factors and Apl2p adaptin beta subunit in yeast.

    PubMed

    Nikawa, Jun-ichi; Yata, Masako; Motomura, Miki; Miyoshi, Nobutaka; Ueda, Tsuyoshi; Hisada, Daisuke

    2006-11-01

    Yeast Ino2p-Ino4p heterodimeric complex is well known as a transcriptional activator for the genes regulated by inositol and choline, such as the INO1 gene. Apl2p is a large subunit of the yeast adaptin complex, an adaptor complex required for the clathrin coat to bind to the membrane. We found that Ino2p, Ino4p, and Apl2p form a ternary complex. This interaction was initially observed in a yeast two-hybrid study and subsequently verified by co-immunoprecipitation. Ino2p and Ino4p bind to Apl2p in the same region of Apl2p, viz., at the middle part and the C-terminal part. Ino2p and Ino4p bind to Apl2p independently, but more strongly when both are present. Furthermore, a disruption of APL2 together with INO2 or INO4 rendered yeast cells sensitive to oxidative stress. INO2-APL2 double disruptants also showed growth inability in non-fermentable carbon sources, such as glycerol. These results indicate a genetic interaction between APL2, INO2 and INO4 and uncovere novel functions of the Ino2p-Ino4p-Apl2p complex in yeast. PMID:17090927

  7. Measurement of the oscillator strengths and autoionization widths of the neutral-aluminum multiplet 3s2 3p2 P0 - 3s 3p2 2P

    NASA Technical Reports Server (NTRS)

    Lombardi, G. G.; Cardon, B. L.; Kurucz, R. L.

    1981-01-01

    The hook method is used in conjunction with absorption equivalent width measurements to determine the oscillator strengths and line widths of the Al I multiplet 3s2 3p2 P0 - 3s 3p2 2P at 176 nm. Autoionization is found to be the dominant decay channel for the two levels of the 3p2 2P term, with autoionizing widths of 4.0 and 0.87 x 10 to the 10th/sec for J of 3/2 and 1/2, respectively. The van der Waals scattering cross section for the Al I transition at 176.91 nm by He is determined to be (1.3 + or - 0.3) x 10 to the -14th sq cm at 2400 K, and a solar spectrum calculation centered at 176 nm shows that the Al I features are possible diagnostic probes of (1) solar non-LTE processes, and (2) the temperature minimum and structure of the lower chromosphere.

  8. Vacuum decay in a soluble model

    SciTech Connect

    Ferraz de Camargo F, A.; Shellard, R.C.; Marques, G.C.

    1984-03-15

    We study a field-theoretical model where the decay rate of the false vacuum can be computed up to the first quantum corrections in both the high-temperature and zero-temperature limits. We find that the dependence of the decay rate on the height and width of the potential barrier does not follow the same simple area rule as in the quantum-mechanical case. Furthermore, its behavior is strongly model dependent.

  9. The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p

    PubMed Central

    Stalder, Danièle; Novick, Peter J.

    2016-01-01

    Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P). Sec2p also binds to the Sec4p effector Sec15p, yet Ypt32p and Sec15p compete against each other for binding to Sec2p. We report here that the redundant casein kinases Yck1p and Yck2p phosphorylate sites within the Ypt32p/Sec15p binding region and in doing so promote binding to Sec15p and inhibit binding to Ypt32p. We show that Yck2p binds to the autoinhibitory domain of Sec2p, adjacent to the PI(4)P binding site, and that addition of PI(4)P inhibits Sec2p phosphorylation by Yck2p. Loss of Yck1p and Yck2p function leads to accumulation of an intracellular pool of the secreted glucanase Bgl2p, as well as to accumulation of Golgi-related structures in the cytoplasm. We propose that Sec2p is phosphorylated after it has been recruited to secretory vesicles and the level of PI(4)P has been reduced. This promotes Sec2p function by stimulating its interaction with Sec15p. Finally, Sec2p is dephosphorylated very late in the exocytic reaction to facilitate recycling. PMID:26700316

  10. Multicast Services over Structured P2P Networks

    NASA Astrophysics Data System (ADS)

    Manzanares-Lopez, Pilar; Malgosa-Sanahuja, Josemaria; Muñoz-Gea, Juan Pedro; Sanchez-Aarnoutse, Juan Carlos

    IP multicast functionality was defined as an efficient method to transmit datagrams to a group of receivers. However, although a lot of research work has been done in this technology, IP multicast has not spread out over the Internet as much as expected, reducing its use for local environments (i.e., LANs). The peer-to-peer networks paradigm can be used to overcome the IP multicast limitations. In this new scenario (called Application Layer Multicast or ALM), the multicast functionality is changed from network to application layer. Although ALM solution can be classified into unstructured and structured solutions, the last ones are the best option to offer multicast services due to the effectiveness in the discovery nodes, their mathematical definition and the totally decentralized management. In this chapter we are going to offer a tutorial of the main structured ALM solutions, but introducing two novelties with respect to related surveys in the past: first, the systematic description of most representative structured ALM solution in OverSim (one of the most popular p2p simulation frameworks). Second, some simulation comparatives between flooding-based and tree-based structured ALM solution are also presented.

  11. Migration of Dust Particles from Comet 2P Encke

    NASA Technical Reports Server (NTRS)

    Ipatov, S. I.

    2003-01-01

    We investigated the migration of dust particles under the gravitational influence of all planets (except for Pluto), radiation pressure, Poynting-Robertson drag and solar wind drag for Beta equal to 0.002, 0.004, 0.01, 0.05, 0.1, 0.2, and 0.4. For silicate particles such values of Beta correspond to diameters equal to about 200, 100, 40, 9, 4, 2, and 1 microns, respectively. We used the Bulirsh-Stoer method of integration, and the relative error per integration step was taken to be less than lo-'. Initial orbits of the particles were close to the orbit of Comet 2P Encke. We considered initial particles near perihelion (runs denoted as Delta tsub o, = 0), near aphelion (Delta tsub o, = 0.5), and also studied their initial positions when the comet moved for Pa/4 after perihelion passage (such runs are denoted as Delta tsub o, =i 0.25), where Pa is the period of the comet. Variations in time T when perihelion was passed was varied with a step 0.1 day for series 'S' and with a step 1 day for series 'L'. For each Beta we considered N = 101 particles for "S" runs and 150 particles for "L" runs.

  12. Lyapunov decay in quantum irreversibility.

    PubMed

    García-Mata, Ignacio; Roncaglia, Augusto J; Wisniacki, Diego A

    2016-06-13

    The Loschmidt echo--also known as fidelity--is a very useful tool to study irreversibility in quantum mechanics due to perturbations or imperfections. Many different regimes, as a function of time and strength of the perturbation, have been identified. For chaotic systems, there is a range of perturbation strengths where the decay of the Loschmidt echo is perturbation independent, and given by the classical Lyapunov exponent. But observation of the Lyapunov decay depends strongly on the type of initial state upon which an average is carried out. This dependence can be removed by averaging the fidelity over the Haar measure, and the Lyapunov regime is recovered, as has been shown for quantum maps. In this work, we introduce an analogous quantity for systems with infinite dimensional Hilbert space, in particular the quantum stadium billiard, and we show clearly the universality of the Lyapunov regime. PMID:27140966

  13. Radioactive Decay - An Analog.

    ERIC Educational Resources Information Center

    McGeachy, Frank

    1988-01-01

    Presents an analog of radioactive decay that allows the student to grasp the concept of half life and the exponential nature of the decay process. The analog is devised to use small, colored, plastic poker chips or counters. Provides the typical data and a graph which supports the analog. (YP)

  14. Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast

    SciTech Connect

    Shimada, Midori; Yamamoto, Ayumu; Murakami-Tonami, Yuko; Nakanishi, Makoto; Yoshida, Takashi; Aiba, Hirofumi; Murakami, Hiroshi

    2009-10-23

    The spindle checkpoint is a surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis. Here we show that fission yeast casein kinase II (CK2) is required for this checkpoint function. In the CK2 mutants mitosis occurs in the presence of a spindle defect, and the spindle checkpoint protein Mad2p fails to localize to unattached kinetochores. The CK2 mutants are sensitive to the microtubule depolymerising drug thiabendazole, which is counteracted by ectopic expression of mad2{sup +}. The level of Mad2p is low in the CK2 mutants. These results suggest that CK2 has a role in the spindle checkpoint by regulating Mad2p.

  15. Magnetism from 2p states in K-doped ZnO monolayer: A density functional study

    NASA Astrophysics Data System (ADS)

    Fang, D. Q.; Zhang, Y.; Zhang, S. L.

    2016-05-01

    Using density-functional–based methods, we have studied 2p-based magnetic moments and magnetic coupling in potassium (K)-doped ZnO monolayer. We find that the substitution of a K atom at a Zn site in a ZnO monolayer induces a magnetic moment of 1.0~μB per cell mainly originating from the O-2p states and has much lower formation energy than a magnetic Zn vacancy. A half-metallic electronic property and long-range ferromagnetic coupling between the magnetic moments are obtained based on the generalized gradient approximation (GGA) calculations, which is explained by a double-exchange–like mechanism. Moreover, with stronger correlation correction on 2p states, the structure of the substitutional K impurity undergoes a Jahn-Teller–like distortion. Incorporating magnetism into a two-dimensional ZnO monolayer will promote its application in nanodevices.

  16. Clg2p interacts with Clf and ClUrase to regulate appressorium formation, pathogenicity and conidial morphology in Curvularia lunata

    PubMed Central

    Liu, Tong; Wang, Yuying; Ma, Bingchen; Hou, Jumei; Jin, Yazhong; Zhang, Youli; Ke, Xiwang; Tai, Lianmei; Zuo, Yuhu; Dey, Kishore

    2016-01-01

    Ras is a small GTPase that regulates numerous processes in the cellular development and morphogenesis of many organisms. In this study, we identified and functionally characterized the Clg2p gene of Curvularia lunata, which is homologous with the Ras protein. The Clg2p deletion mutant (ΔClg2p) had altered appressorium formation and conidial morphology and produced fewer, smaller lesions compared with the wild-type strain. When a dominant Clg2p allele was introduced into the mutant, all of these defective phenotypes were completely restored. To further understand the regulation of Clg2p in appressorium formation and conidial morphology, and its role in pathogenicity, seven Clg2p-interacting proteins were screened using a yeast two-hybrid assay. Two of these proteins, Clf, a homologue of Mst11, which corresponds to MAP kinase kinase kinase in Magnaporthe oryzae, and urate oxidase (designated ClUrase) were functionally characterized. Clg2p specifically interacted with Clf through its RA domain to regulate appressorium formation and pathogenicity, whereas the Clg2p-ClUrase interaction regulated conidial morphology without affecting fungal pathogenicity. This report is the first to elucidate the regulatory mechanism of the key Ras protein Clg2p in C. lunata. PMID:27041392

  17. Clg2p interacts with Clf and ClUrase to regulate appressorium formation, pathogenicity and conidial morphology in Curvularia lunata.

    PubMed

    Liu, Tong; Wang, Yuying; Ma, Bingchen; Hou, Jumei; Jin, Yazhong; Zhang, Youli; Ke, Xiwang; Tai, Lianmei; Zuo, Yuhu; Dey, Kishore

    2016-01-01

    Ras is a small GTPase that regulates numerous processes in the cellular development and morphogenesis of many organisms. In this study, we identified and functionally characterized the Clg2p gene of Curvularia lunata, which is homologous with the Ras protein. The Clg2p deletion mutant (ΔClg2p) had altered appressorium formation and conidial morphology and produced fewer, smaller lesions compared with the wild-type strain. When a dominant Clg2p allele was introduced into the mutant, all of these defective phenotypes were completely restored. To further understand the regulation of Clg2p in appressorium formation and conidial morphology, and its role in pathogenicity, seven Clg2p-interacting proteins were screened using a yeast two-hybrid assay. Two of these proteins, Clf, a homologue of Mst11, which corresponds to MAP kinase kinase kinase in Magnaporthe oryzae, and urate oxidase (designated ClUrase) were functionally characterized. Clg2p specifically interacted with Clf through its RA domain to regulate appressorium formation and pathogenicity, whereas the Clg2p-ClUrase interaction regulated conidial morphology without affecting fungal pathogenicity. This report is the first to elucidate the regulatory mechanism of the key Ras protein Clg2p in C. lunata. PMID:27041392

  18. Observation of Two-Proton Radioactivity of {sup 19}Mg by Tracking the Decay Products

    SciTech Connect

    Mukha, I.; Alvarez, M. A. G.; Espino, J.; Gomez-Camacho, J.; Suemmerer, K.; Chatillon, A.; Geissel, H.; Hoffmann, J.; Kurz, N.; Litvinov, Yu.; Nociforo, C.; Ott, W.; Roeckl, E.; Weick, H.; Acosta, L.; Garcia-Ramos, J. E.; Martel, I.; Casarejos, E.; Cortina-Gil, D.; Rodriguez-Tajes, C.

    2007-11-02

    We have observed the two-proton radioactivity of the previously unknown {sup 19}Mg ground state by tracking the decay products in-flight. For the first time, the trajectories of the 2p-decay products, {sup 17}Ne+p+p, have been measured by using tracking microstrip detectors which allowed us to reconstruct the 2p-decay vertices and fragment correlations. The half-life of {sup 19}Mg deduced from the measured vertex distribution is 4.0(15) ps in the system of {sup 19}Mg. The Q value of the 2p decay of the {sup 19}Mg ground state inferred from the measured p-p-{sup 17}Ne correlations is 0.75(5) MeV.

  19. Decay of turbulence at high reynolds numbers.

    PubMed

    Sinhuber, Michael; Bodenschatz, Eberhard; Bewley, Gregory P

    2015-01-23

    Turbulent motions in a fluid decay at a certain rate once stirring has stopped. The role of the most basic parameter in fluid mechanics, the Reynolds number, in setting the decay rate is not generally known. This Letter concerns the high-Reynolds-number limit of the process. In a classical grid-turbulence wind-tunnel experiment that both reaches higher Reynolds numbers than ever before and covers a wide range of them (10^{4}decay rate with the unprecedented precision of about 2%. Here U is the mean speed of the flow, M is the forcing scale, and ν is the kinematic viscosity of the fluid. We observe that the decay rate is Reynolds-number independent, which contradicts some models and supports others. PMID:25659002

  20. Decay of Turbulence at High Reynolds Numbers

    NASA Astrophysics Data System (ADS)

    Sinhuber, Michael; Bodenschatz, Eberhard; Bewley, Gregory P.

    2015-01-01

    Turbulent motions in a fluid decay at a certain rate once stirring has stopped. The role of the most basic parameter in fluid mechanics, the Reynolds number, in setting the decay rate is not generally known. This Letter concerns the high-Reynolds-number limit of the process. In a classical grid-turbulence wind-tunnel experiment that both reaches higher Reynolds numbers than ever before and covers a wide range of them (1 04decay rate with the unprecedented precision of about 2%. Here U is the mean speed of the flow, M is the forcing scale, and ν is the kinematic viscosity of the fluid. We observe that the decay rate is Reynolds-number independent, which contradicts some models and supports others.

  1. Decaying neutrinos: The long way to isotropy

    SciTech Connect

    Basboell, Anders; Bjaelde, Ole Eggers

    2010-06-15

    We investigate a scenario in which neutrinos are coupled to a pseudoscalar degree of freedom {phi} and where decays {nu}{sub 1{yields}{nu}2}+{phi} and inverse decays are the responsible mechanism for obtaining equilibrium. In this context we discuss the implication of the invisible neutrino decay on the neutrino-pseudoscalar coupling constant and the neutrino lifetime. Assuming the realistic scenario of a thermal background of neutrinos and pseudoscalar we update the bound on the (off-diagonal) neutrino-pseudoscalar coupling constant to g<2.6x10{sup -13} and the bound on the neutrino lifetime to {tau}>1x10{sup 13} s. Furthermore we confirm analytically that kinetic equilibrium is delayed by two Lorentz {gamma} factors--one for time dilation of the (decaying) neutrino lifetime and one from the opening angle. We have also confirmed this behavior numerically.

  2. Energetics of addition versus insertion mechanisms in the Si +( 2P) + HCOOH reaction

    NASA Astrophysics Data System (ADS)

    González, A. I.; Yáñez, M.

    1996-01-01

    High-level ab initio calculations have been performed to investigate the preference of insertion processes with respect to the formation of adducts in the Si + + formic acid reaction in the gas phase. We have found that the reactivity patterns shown by Si + in reactions with methanol and formaldehyde are significantly different from those exhibited with formic acid, which has both functional groups. The most stable product of the reaction between Si + and HCOOH corresponds to the insertion of the monocation into the COH bond of the neutral. Mostly importantly, the Si + association to the carbonyl oxygen atom is only 4.9 kcal/mol less favourable. All investigated local minima lie below the reactants in energy. In agreement with the experimental evidence, the formation of SiOH + as a possible product of the Si + + HCOOH reaction is predicted to be exothermic by 41.7 kcal/mol. The distonic character of the products is discussed as well as the harmonic vibrational frequencies of the global minimum.

  3. Axions from wall decay

    SciTech Connect

    Chang, S; Hagmann, C; Sikivie, P

    2001-01-08

    The authors discuss the decay of axion walls bounded by strings and present numerical simulations of the decay process. In these simulations, the decay happens immediately, in a time scale of order the light travel time, and the average energy of the radiated axions is {approx_equal} 7m{sub a} for v{sub a}/m{sub a} {approx_equal} 500. is found to increase approximately linearly with ln(v{sub a}/m{sub a}). Extrapolation of this behavior yields {approx_equal} 60 m{sub a} in axion models of interest.

  4. Modulated curvaton decay

    SciTech Connect

    Assadullahi, Hooshyar; Wands, David; Firouzjahi, Hassan; Namjoo, Mohammad Hossein E-mail: firouz@mail.ipm.ir E-mail: david.wands@port.ac.uk

    2013-03-01

    We study primordial density perturbations generated by the late decay of a curvaton field whose decay rate may be modulated by the local value of another isocurvature field, analogous to models of modulated reheating at the end of inflation. We calculate the primordial density perturbation and its local-type non-Gaussianity using the sudden-decay approximation for the curvaton field, recovering standard curvaton and modulated reheating results as limiting cases. We verify the Suyama-Yamaguchi inequality between bispectrum and trispectrum parameters for the primordial density field generated by multiple field fluctuations, and find conditions for the bound to be saturated.

  5. Growth and characterization of VO2/p-GaN/sapphire heterostructure with phase transition properties

    NASA Astrophysics Data System (ADS)

    Bian, Jiming; Wang, Minhuan; Miao, Lihua; Li, Xiaoxuan; Luo, Yingmin; Zhang, Dong; Zhang, Yuzhi

    2015-12-01

    High quality pure phase VO2 films were deposited on p-GaN/sapphire substrates by pulsed laser deposition (PLD). A well-defined interface with dense and uniform morphology was observed in the as-grown VO2/p-GaN/sapphire heterostructure. The X-ray photoelectron spectroscopy (XPS) analyses confirmed the valence state of vanadium (V) in VO2 films was principally composed of V4+ with trace amount of V5+, no other valence state of V was detected. Meanwhile, a distinct reversible semiconductor-to-metal (SMT) phase transition with resistance change up to nearly three orders of magnitude was observed in the temperature dependent electrical resistance measurement, which was comparable to the high quality VO2 film grown directly on sapphire substrates. Our present findings will give a deeper insight into the physical mechanism behind the exotic characteristics of VO2/p-GaN heterostructure, and further motivate research in novel devices with combined functional properties of both correlated oxide and wide bandgap nitride semiconductors.

  6. TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions

    PubMed Central

    Cid, L. Pablo; Roa-Rojas, Hugo A.; Niemeyer, María I.; González, Wendy; Araki, Masatake; Araki, Kimi; Sepúlveda, Francisco V.

    2013-01-01

    TASK-2 (K2P5.1) is a two-pore domain K+ channel belonging to the TALK subgroup of the K2P family of proteins. TASK-2 has been shown to be activated by extra- and intracellular alkalinization. Extra- and intracellular pH-sensors reside at arginine 224 and lysine 245 and might affect separate selectivity filter and inner gates respectively. TASK-2 is modulated by changes in cell volume and a regulation by direct G-protein interaction has also been proposed. Activation by extracellular alkalinization has been associated with a role of TASK-2 in kidney proximal tubule bicarbonate reabsorption, whilst intracellular pH-sensitivity might be the mechanism for its participation in central chemosensitive neurons. In addition to these functions TASK-2 has been proposed to play a part in apoptotic volume decrease in kidney cells and in volume regulation of glial cells and T-lymphocytes. TASK-2 is present in chondrocytes of hyaline cartilage, where it is proposed to play a central role in stabilizing the membrane potential. Additional sites of expression are dorsal root ganglion neurons, endocrine and exocrine pancreas and intestinal smooth muscle cells. TASK-2 has been associated with the regulation of proliferation of breast cancer cells and could become target for breast cancer therapeutics. Further work in native tissues and cells together with genetic modification will no doubt reveal the details of TASK-2 functions that we are only starting to suspect. PMID:23908634

  7. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

    PubMed

    McClenaghan, Conor; Schewe, Marcus; Aryal, Prafulla; Carpenter, Elisabeth P; Baukrowitz, Thomas; Tucker, Stephen J

    2016-06-01

    The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the "up" and "down" conformations. However, recent studies have resulted in contradictory and mutually exclusive conclusions about the functional (i.e., conductive) status of these two conformations. To address this problem, we have used the state-dependent TREK-2 inhibitor norfluoxetine that can only bind to the down state, thereby allowing us to distinguish between these two conformations when activated by different stimuli. Our results reconcile these previously contradictory gating models by demonstrating that activation by pressure, temperature, voltage, and pH produce more than one structurally distinct open state and reveal that channel activation does not simply involve switching between the up and down conformations. These results also highlight the diversity of structural mechanisms that K2P channels use to integrate polymodal gating signals. PMID:27241700

  8. Application of the Dimensional Reduction Formalism to Pb12[Li2(P2O7)2(P4O13)2](P4O13): a Phosphate Containing Three Types of Isolated P-O Groups.

    PubMed

    Zhang, Xiangyu; Wu, Hongping; Wang, Ying; Dong, Xiaoyu; Han, Shujuan; Pan, Shilie

    2016-08-01

    A new phosphate, Pb12[Li2(P2O7)2(P4O13)2](P4O13), containing three types of isolated polyphosphate anionic groups [P2O7], and two types of [P4O13] has been successfully synthesized by using Li2O as dimensional reduction agent to dismantle Pb3P4O13. The isolation of [P2O7] and two types of [P4O13] with different symmetries in the title compound mainly benefits from the large number and flexible coordination of the Pb(2+) cations. PMID:27399881

  9. Membrane translocation of mitochondrially coded Cox2p: distinct requirements for export of N and C termini and dependence on the conserved protein Oxa1p.

    PubMed Central

    He, S; Fox, T D

    1997-01-01

    To study in vivo the export of mitochondrially synthesized protein from the matrix to the intermembrane space, we have fused a synthetic mitochondrial gene, ARG8m, to the Saccharomyces cerevisiae COX2 gene in mitochondrial DNA. The Arg8mp moiety was translocated through the inner membrane when fused to the Cox2p C terminus by a mechanism dependent on topogenic information at least partially contained within the exported Cox2p C-terminal tail. The pre-Cox2p leader peptide did not signal translocation. Export of the Cox2p C-terminal tail, but not the N-terminal tail, was dependent on the inner membrane potential. The mitochondrial export system does not closely resemble the bacterial Sec translocase. However, normal translocation of both exported domains of Cox2p was defective in cells lacking the widely conserved inner membrane protein Oxa1p. Images PMID:9285818

  10. The splitting and oscillator strengths for the 2S/2/S-2p/2/P/0/ doublet in lithium-like sulfur. [during Skylab observed solar flares

    NASA Technical Reports Server (NTRS)

    Pegg, D. J.; Forester, J. P.; Elston, S. B.; Griffin, P. M.; Peterson, R. S.; Thoe, R. S.; Vane, C. R.; Sellin, I. A.; Groeneveld, K.-O.

    1977-01-01

    The beam-foil technique has been used to study the 2S(2)S-2p(2)P(0) doublet in S XIV. The results confirm the doublet splitting measured aboard Skylab during solar flare events. In addition, the oscillator strengths for the resonance transitions comprising this doublet have been measured and found to agree well with recent relativistic f-value calculations.

  11. Dissipationless decay of Jovian jets

    NASA Astrophysics Data System (ADS)

    Pirraglia, J. A.

    1989-05-01

    IRIS data have been taken as the bases of windshear calculations whose results imply a decrease of the Jovian planet's zonal jets with altitude. The simplified dynamical model developed to furnish a mechanism accounting for the decay involves a highly truncated set of dissipationless equations simulating the upper-tropospheric and stratospheric flow. While the model's lower boundary is constrained as a latitudinally periodic set of alternating jets, the upper boundary constraint maintains a constant potential temperature. The small perturbations to which the imposed zonal jets are unstable grow and interact nonlinearly, generating a zonal flow that opposes the imposed one and thereby leading to the apparent decrease of the jets with altitude.

  12. Bremsstrahlung in {alpha} Decay Reexamined

    SciTech Connect

    Boie, H.; Scheit, H.; Jentschura, U. D.; Koeck, F.; Lauer, M.; Schwalm, D.; Milstein, A. I.; Terekhov, I. S.

    2007-07-13

    A high-statistics measurement of bremsstrahlung emitted in the {alpha} decay of {sup 210}Po has been performed, which allows us to follow the photon spectra up to energies of {approx}500 keV. The measured differential emission probability is in good agreement with our theoretical results obtained within the quasiclassical approximation as well as with the exact quantum mechanical calculation. It is shown that, due to the small effective electric dipole charge of the radiating system, a significant interference between the electric dipole and quadrupole contributions occurs, which is altering substantially the angular correlation between the {alpha} particle and the emitted photon.

  13. Particle statistics affects quantum decay and Fano interference.

    PubMed

    Crespi, Andrea; Sansoni, Linda; Della Valle, Giuseppe; Ciamei, Alessio; Ramponi, Roberta; Sciarrino, Fabio; Mataloni, Paolo; Longhi, Stefano; Osellame, Roberto

    2015-03-01

    Quantum mechanical decay, Fano interference, and bound states with energy in the continuum are ubiquitous phenomena in different areas of physics. Here we experimentally demonstrate that particle statistics strongly affects quantum mechanical decay in a multiparticle system. By considering propagation of two-photon states in engineered photonic lattices, we simulate quantum decay of two noninteracting particles in a multilevel Fano-Anderson model. Remarkably, when the system sustains a bound state in the continuum, fractional decay is observed for bosonic particles, but not for fermionic ones. Complete decay in the fermionic case arises because of the Pauli exclusion principle, which forbids the bound state to be occupied by the two fermions. Our experiment indicates that particle statistics can tune many-body quantum decay from fractional to complete. PMID:25793783

  14. Radiative B Decays

    SciTech Connect

    Bard, D.; /Imperial Coll., London

    2011-11-23

    I discuss recent results in radiative B decays from the Belle and BaBar collaborations. I report new measurements of the decay rate and CP asymmetries in b {yields} s{gamma} and b {yields} d{gamma} decays, and measurements of the photon spectrum in b {yields} s{gamma}. Radiative penguin decays are flavour changing neutral currents which do not occur at tree level in the standard model (SM), but must proceed via one loop or higher order diagrams. These transitions are therefore suppressed in the SM, but offer access to poorlyknown SM parameters and are also a sensitive probe of new physics. In the SM, the rate is dominated by the top quark contribution to the loop, but non-SM particles could also contribute with a size comparable to leading SM contributions. The new physics effects are potentially large which makes them theoretically very interesting, but due to their small branching fractions they are typically experimentally challenging.

  15. RARE KAON DECAYS.

    SciTech Connect

    LITTENBERG, L.

    2005-07-19

    Lepton flavor violation (LFV) experiments have probed sensitivities corresponding to mass scales of well over 100 TeV, making life difficult for models predicting accessible LFV in kaon decay and discouraging new dedicated experiments of this type.

  16. Tooth decay - early childhood

    MedlinePlus

    Bottle mouth; Bottle carries; Baby bottle tooth decay; Early childhood caries (ECC) ... chap 304. Ribeiro NM, Ribeiro MA. Breastfeeding and early childhood caries: a critical review. J Pediatr (Rio J) . ...

  17. Efficient Water Electrolysis Using Ni2P as a Bifunctional Catalyst: Unveiling the Oxygen Evolution Catalytic Properties of Ni2P.

    PubMed

    Stern, Lucas-Alexandre; Hu, Xile

    2016-01-01

    The excellent bifunctional catalytic activity of nickel phosphide (Ni2P) for water splitting is reported. Ni2P, an active hydrogen evolving catalyst, is shown to be highly active for oxygen evolution. Only 290 mV of overpotential is required to generate a current density of 10 mA cm(-2) in 1 M KOH. Under oxygen evolving conditions, Ni2P undergoes structural modification to form a Ni2P/NiOx core-shell assembly, the catalytic active species. Ni2P is applied on both electrodes of an alkaline electrolyser and a current density of 10 mA cm(-2) is generated at 1.63 V. PMID:27131107

  18. 2s2 2p5-2s2p6 transitions in fluorinelike ions from Zr(31+) to Sn(41+)

    NASA Technical Reports Server (NTRS)

    Reader, Joseph; Brown, C. M.; Ekberg, J. O.; Feldman, U.; Seely, J. F.; Behring, W. E.

    1986-01-01

    Transitions of the type 2s2 2p5-2s2p6 have been observed in eight fluorinelike ions from Zr(31+) to Sn(41+). The spectra were produced by focusing light from the Nd:glass Omega laser at the University of Rochester onto solid targets and photographing the resultant plasmas with a 3-m grazing-incidence spectrograph. The identified transitions are in the region 24-60 A. The measured wavelengths are in good agreement with wavelengths calculated with the semiempirical formulas of Edlen (1983). Wavelengths for the 2s2 2p5 2P3/2-2P1/2 magnetic-dipole transitions are given for each ion.

  19. Experimental study of the 15O(2p, γ)17Ne cross section by Coulomb Dissociation for the rp process

    NASA Astrophysics Data System (ADS)

    Marganiec, J.; Warners, F.; Aksouh, F.; Aksyutina, Y.; Alvarez Pol, H.; Aumann, T.; Beceiro, S.; Bertulani, C.; Boretzky, K.; Borge, M. J.; Chartier, M.; Chatillon, A.; Chulkov, L.; Cortina-Gil, D.; Egorova, I.; Emling, H.; Ershova, O.; Forssén, C.; Fraile, L. M.; Fynbo, H.; Galaviz, D.; Geissel, H.; Grigorenko, L.; Heil, M.; Hoffmann, D. H. H.; Hoffmann, J.; Johansson, H.; Jonson, B.; Karakoç, M.; Karagiannis, C.; Kiselev, O.; Kratz, J. V.; Kulessa, R.; Kurz, N.; Langer, C.; Lantz, M.; Larsson, K.; Le Bleis, T.; Lemmon, R.; Litvinov, Yu A.; Mahata, K.; Müntz, C.; Nilsson, T.; Nociforo, C.; Nyman, G.; Ott, W.; Panin, V.; Parfenova, Yu; Paschalis, S.; Perea, A.; Plag, R.; Reifarth, R.; Richter, A.; Riisager, K.; Rodríguez Tajes, C.; Rossi, D.; Schrieder, G.; Shulgina, N.; Simon, H.; Stroth, J.; Sümmerer, K.; Taylor, J.; Tengblad, O.; Tengborn, E.; Weick, H.; Wiescher, M.; Wimmer, C.; Zhukov, M.

    2016-01-01

    The time-reversed reaction 15O(2p, γ)17Ne has been studied by the Coulomb dissociation technique. Secondary 17Ne ion beams at 500 AMeV have been produced by fragmentation reactions of 20Ne in a beryllium production target and dissociated on a secondary Pb target. The incoming beam and the reaction products have been identified with the kinematically complete LAND-R3B experimental setup at GSI. The excitation energy prior to decay has been reconstructed by using the invariant-mass method. The preliminary differential and integral Coulomb Dissociation cross sections (σCoul) have been calculated, which provide a photoabsorption (σphoto) and a radiative capture cross section (σcap). Additionally, important information about the nuclear structure of the 17Ne nucleus will be obtained. The analysis is in progress.

  20. Molecular identification of the dominant-negative, splicing isoform of the two-pore domain K(+) channel K(2P)5.1 in lymphoid cells and enhancement of its expression by splicing inhibition.

    PubMed

    Endo, Kyoko; Kurokawa, Natsumi; Kito, Hiroaki; Nakakura, Sawa; Fujii, Masanori; Ohya, Susumu

    2015-12-01

    The two-pore domain background K(+) channel K2P5.1 is expected as a possible therapeutic target for autoimmune and inflammatory disorders and cancers because it plays an important role in maintaining the resting membrane potential and regulation of Ca(2+) signaling in T lymphocytes and cancer cells. However, the lack of selective K2P5.1 blockers has led to difficulties conducting experimental studies on this K(+) channel. We identified a novel splicing isoform of K2P5.1, K2P5.1B from the mammalian spleen, which lacked the N-terminus of full-length K2P5.1A. A co-immunoprecipitation assay using mice spleen lysates revealed an interaction between K2P5.1A and K2P5.1B in the cytoplasmic C-terminal domain. In a heterologous HEK293 expression system, K2P5.1B inhibited the trafficking of K2P5.1A to the plasma membrane. The alkaline pHe-induced hyperpolarizing response was significantly suppressed in K2P5.1B-transfected human leukemia K562 cells. Enhancement in cell proliferation by the overexpression of K2P5.1A in K562 was significantly prevented by the transfection of K2P5.1B. The spliceosome inhibitor pladienolide B significantly enhanced the relative expression of K2P5.1B in K562, resulting in decreases in the activity of K2P5.1A. K2P5.1B suppresses the function of the K2P5.1 K(+) channel in a dominant-negative manner, suggesting that the mRNA splicing mechanisms underlying the transcriptional regulation of K2P5.1B may be a new therapeutic strategy for autoimmune and inflammatory disorders and cancers. PMID:26475531

  1. Systems genetics analyses predict a transcription role for P2P-R: Molecular confirmation that P2P-R is a transcriptional co-repressor

    PubMed Central

    2010-01-01

    Background The 250 kDa P2P-R protein (also known as PACT and Rbbp6) was cloned over a decade ago and was found to bind both the p53 and Rb1 tumor suppressor proteins. In addition, P2P-R has been associated with multiple biological functions, such as mitosis, mRNA processing, translation and ubiquitination. In the current studies, the online GeneNetwork system was employed to further probe P2P-R biological functions. Molecular studies were then performed to confirm the GeneNetwork evaluations. Results GeneNetwork and associated gene ontology links were used to investigate the coexpression of P2P-R with distinct functional sets of genes in an adipocyte genetic reference panel of HXB/BXH recombinant strains of rats and an eye genetic reference panel of BXD recombinant inbred strains of mice. The results establish that biological networks of 75 and 135 transcription-associated gene products that include P2P-R are co-expressed in a genetically-defined manner in rat adipocytes and in the mouse eye, respectively. Of this large set of transcription-associated genes, >10% are associated with hormone-mediated transcription. Since it has been previously reported that P2P-R can bind the SRC-1 transcription co-regulatory factor (steroid receptor co-activator 1, [Ncoa1]), the possible effects of P2P-R on estrogen-induced transcription were evaluated. Estrogen-induced transcription was repressed 50-70% by the transient transfection of P2P-R plasmid constructs into four different cell types. In addition, knockdown of P2P-R expression using an antisense oligonucleotide increased estrogen-mediated transcription. Co-immunoprecipitation assays confirmed that P2P-R interacts with SRC-1 and also demonstrated that P2P-R interacts with estrogen receptor α. Conclusions The findings presented in this study provide strong support for the value of systems genetics, especially GeneNetwork, in discovering new functions of genes that can be confirmed by molecular analysis. More specifically

  2. Observation of the Forbidden Magnetic Dipole Transition 6{sup 2}P{sub ½} --> 7{sup 2}P{sub ½} in Atomic Thallium

    DOE R&D Accomplishments Database

    Chu, S.

    1976-10-01

    A measurement of the 6{sup 2}P{sub ½} --> 7{sup 2}P{sub ½} forbidden magnetic dipole matrix element in atomic thallium is described. A pulsed, linearly polarized dye laser tuned to the transition frequency is used to excite the thallium vapor from the 6{sup 2}P{sub ½} ground state to the 7{sup 2}P{sub ½} excited state. Interference between the magnetic dipole M1 amplitude and a static electric field induced E1 amplitude results in an atomic polarization of the 7{sup 2}P{sub ½} state, and the subsequent circular polarization of 535 nm fluorescence. The circular polarization is seen to be proportional to / as expected, and measured for several transitions between hyperfine levels of the 6{sup 2}P{sub ½} and 7{sup 2}P{sub ½} states. The result is = -(2.11 +- 0.30) x 10{sup -5} parallel bar e parallel bar dirac constant/2mc, in agreement with theory.

  3. Evidence for the non-statistical population of the 1s2s2p4P metastable state by electron capture in 4 MeV collisions of B3+(1s2s 3S) with H2 targets

    NASA Astrophysics Data System (ADS)

    Benis, E. P.; Doukas, S.; Zouros, T. J. M.

    2016-02-01

    We have revisited previously published data involving collisions of mixed 4 MeV B3+ (1s21 S, 1 s 2 s3 S) with H2 targets (Benis et al., 2002) in search of evidence for the non-statistical production of the 1 s 2 s 2 p4 P long-lived metastable state by single electron capture. Using our recently published method for the accurate determination of the effective solid angle of Auger decaying metastable projectile states in combination with knowledge of the 1 s 2 s3 S metastable beam fraction allowed us to determine the ratio R =4 P /2 P of 1 s 2 s 2 p quartet to doublet production cross sections both formed by electron capture. Our present determination of R = 2.8 ± 0.5 , clearly departs from the expected value of R = 2 based on statistical spin recoupling arguments and thus provides evidence for the active presence of additional population mechanisms in a new collision system.

  4. A Novel P2P traffic Prediction Algorithm Based on Hybrid Model

    NASA Astrophysics Data System (ADS)

    Zhi-jie, Han; Ru-chuan, Wang; Xiao-yang, Duan

    The increasing P2P network traffic on the Internet has leaded to the problem of network congestion. In the consequence of the diversification of the P2P traffic and protocol, research on the management of P2P traffic has had many problems needed to resolve. P2P traffic Prediction is kernel problem in the P2P traffic management. Based on the P2P traffic characters, this thesis present a P2P traffic model, gived a traffic prediction algorithm bases on wavelet-analysis, and proved the accuracy of the algorithm. Simulation has experiment figures that the algorithm a high prediction precision and superior real-time performance.

  5. Influence of chemical bonds on the lifetime of the molecular-field-split 2p levels in H{sub 2}S

    SciTech Connect

    Bueno, Andre Machado; Brito, Arnaldo Naves de; Fink, Reinhold F.; Baessler, Margit; Bjoerneholm, Olle; Burmeister, Florian; Feifel, Raimund; Miron, Catalin; Sorensen, Stacey L.; Wang Honghong; Svensson, Svante

    2003-02-01

    Different lifetime broadenings in molecular-field-split 2p core levels in H{sub 2}S are predicted theoretically and are identified in an experimental investigation of the S 2p Auger electron spectrum. The measurements were performed for the transition to the vibrationally resolved X{sup 1}A{sub 1} ground state of H{sub 2}S{sup 2+}. The lifetimes of the 3e{sub 1/2} and 5e{sub 1/2} levels of the 2p ionized molecule are found to be 64 and 74 meV, respectively. This unambiguous determination of the lifetime difference of 10{+-}1 meV is only possible as the 4e{sub 1/2}{yields}X{sup 1}A{sub 1}(2b{sub 1}{sup -2}) decay channel that overlaps the 5e{sub 1/2}{yields}X{sup 1}A{sub 1}(2b{sub 1}{sup -2}) channel is practically suppressed in Auger decay in H{sub 2}S. The lifetime difference is confirmed by ab initio calculations. A theoretical analysis shows that it results from the mutual orientation of the core hole in the intermediate states and the valence electron density in the sulfur 3p orbitals. Both are strongly influenced by the chemical bond. Thus the observed effect is the direct result of a fundamental property of molecular electronic structure.

  6. Relativistic CI calculations of spectroscopic data for the 2p6 and 2p53l configurations in Ne-like ions between Mg III and Kr XXVII

    NASA Astrophysics Data System (ADS)

    Jönsson, P.; Bengtsson, P.; Ekman, J.; Gustafsson, S.; Karlsson, L. B.; Gaigalas, G.; Froese Fischer, C.; Kato, D.; Murakami, I.; Sakaue, H. A.; Hara, H.; Watanabe, T.; Nakamura, N.; Yamamoto, N.

    2014-01-01

    Energies, E1, M1, E2, M2 transition rates, oscillator strengths, and lifetimes from relativistic configuration interaction calculations are reported for the states of the 2p6, 2p53s, 2p53p, and 2p53d, configurations in all Ne-like ions between Mg III and Kr XXVII. Core-valence and core-core correlation effects are accounted for through single and double excitations to increasing sets of active orbitals. The Breit interaction and leading quantum electrodynamic effects are included as perturbations. The results are compared with experiments and other recent benchmark calculations. In Mg III, Al IV, Si V, P VI, S VII, and Ar IX, for which experimental energies are known to high accuracy, the mean error in the calculated energies is only 0.011%.

  7. Neutrinoless Double Beta Decay

    NASA Astrophysics Data System (ADS)

    Cremonesi, Oliviero

    2016-05-01

    After more than 3/4 of century from its proposal, Neutrinoless Double Beta Decay (NLDBD) is still missing observation and continues to represent the only practical method for investigating the Dirac/Majorana nature of neutrinos. In case neutrinos would be Majorana particles, NLDBD would provide unique informations on their properties (absolute mass scale and Majorana phases). Boosted by the discovery of neutrino oscillations, a number of experiments with improved sensitivity have been proposed in the past decade. Some of them have recently started operation and others are ready to start. They will push the experimental sensitivity on the decay halflife beyond 1026 year, starting to analyze the region of the inverted mass hierarchy. The status and perspectives of the ongoing experimental effort are reviewed. Uncertainties coming from the calculation othe decay nuclear matrix elements (NME) as well as the recently suggested possibility of a relevant quenching of the axial coupling constant are also discussed.

  8. Decay of superdeformed bands

    SciTech Connect

    Carpenter, M.P.; Khoo, T.L.; Lauritsen, T.

    1995-12-31

    One of the major challenges in the study of superdeformation is to directly connect the large number of superdeformed bands now known to the yrast states. In this way, excitation energies, spins and parities can be assigned to the levels in the second well which is essential to establish the collective and single-particle components of these bands. This paper will review some of the progress which has been made to understand the decay of superdeformed bands using the new arrays including the measurement of the total decay spectrum and the establishment of direct one-step decays from the superdeformed band to the yrast line in {sup 194}Hg. 42 refs., 5 figs.

  9. Suppressed Charmed B Decay

    SciTech Connect

    Snoek, Hella Leonie

    2009-06-02

    This thesis describes the measurement of the branching fractions of the suppressed charmed B0 → D*- a0+ decays and the non-resonant B0 → D*- ηπ+ decays in approximately 230 million Υ(4S) → B$\\bar{B}$ events. The data have been collected with the BABAR detector at the PEP-II B factory at the Stanford Linear Accelerator Center in California. Theoretical predictions of the branching fraction of the B0 → D*- a{sub 0}+ decays show large QCD model dependent uncertainties. Non-factorizing terms, in the naive factorization model, that can be calculated by QCD factorizing models have a large impact on the branching fraction of these decay modes. The predictions of the branching fractions are of the order of 10-6. The measurement of the branching fraction gives more insight into the theoretical models. In general a better understanding of QCD models will be necessary to conduct weak interaction physics at the next level. The presence of CP violation in electroweak interactions allows the differentiation between matter and antimatter in the laws of physics. In the Standard Model, CP violation is incorporated in the CKM matrix that describes the weak interaction between quarks. Relations amongst the CKM matrix elements are used to present the two relevant parameters as the apex of a triangle (Unitarity Triangle) in a complex plane. The over-constraining of the CKM triangle by experimental measurements is an important test of the Standard Model. At this moment no stringent direct measurements of the CKM angle γ, one of the interior angles of the Unitarity Triangle, are available. The measurement of the angle γ can be performed using the decays of neutral B mesons. The B0 → D*- a0+ decay is sensitive to the angle γ and, in comparison to the current decays that are being employed, could significantly

  10. Weak decay of hypernuclei

    SciTech Connect

    Grace, R.

    1983-01-01

    The Moby Dick spectrometer (at BNL) in coincidence with a range spectrometer and a TOF neutron detector will be used to study the weak decay modes of /sup 12/C. The Moby Dick spectrometer will be used to reconstruct and tag events in which specific hypernuclear states are formed in the reaction K/sup -/ + /sup 12/C ..-->.. ..pi../sup -/ + /sup 12/C. Subsequent emission of decay products (pions, protons and neutrons) in coincidence with the fast forward pion will be detected in a time and range spectrometer, and a neutron detector.

  11. Search for the decay

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; d'Argent, P.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Birnkraut, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Brett, D.; Britsch, M.; Britton, T.; Brodzicka, J.; Brook, N. H.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Campora Perez, D.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casanova Mohr, R.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cavallero, G.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chefdeville, M.; Chen, S.; Cheung, S.-F.; Chiapolini, N.; Chrzaszcz, M.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Dean, C.-T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Ruscio, F.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dreimanis, K.; Dujany, G.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Färber, C.; Farinelli, C.; Farley, N.; Farry, S.; Fay, R.; Ferguson, D.; Fernandez Albor, V.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fol, P.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; García Pardiñas, J.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gascon, D.; Gaspar, C.; Gastaldi, U.; Gauld, R.; Gavardi, L.; Gazzoni, G.; Geraci, A.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Gianì, S.; Gibson, V.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gotti, C.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graverini, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Humair, T.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kelsey, M.; Kenyon, I. R.; Kenzie, M.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Klimaszewski, K.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Likhomanenko, T.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lucchesi, D.; Lucio Martinez, M.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Machefert, F.; Maciuc, F.; Maev, O.; Malde, S.; Malinin, A.; Manca, G.; Mancinelli, G.; Manning, P.; Mapelli, A.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marino, P.; Märki, R.; Marks, J.; Martellotti, G.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Matthieu, K.; Mauri, A.; Maurin, B.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D. A.; Minard, M.-N.; Mitzel, D. S.; Molina Rodriguez, J.; Monteil, S.; Morandin, M.; Morawski, P.; Mordà, A.; Morello, M. J.; Moron, J.; Morris, A. B.; Mountain, R.; Muheim, F.; Müller, J.; Müller, K.; Müller, V.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen, T. D.; Nguyen-Mau, C.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Ninci, D.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, C. J. G.; Osorio Rodrigues, B.; Otalora Goicochea, J. M.; Otto, A.; Owen, P.; Oyanguren, A.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Parkes, C.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petruzzo, M.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilař, T.; Pinci, D.; Pistone, A.; Playfer, S.; Plo Casasus, M.; Poikela, T.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Price, E.; Price, J. D.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Quagliani, R.; Rachwal, B.; Rademacker, J. H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redi, F.; Reichert, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Robbe, P.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Lopez, J. A.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruiz, H.; Ruiz Valls, P.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sepp, I.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Silva Coutinho, R.; Simi, G.; Sirendi, M.; Skidmore, N.; Skillicorn, I.; Skwarnicki, T.; Smith, E.; Smith, E.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Sterpka, F.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Stroili, R.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Tekampe, T.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Todd, J.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Trabelsi, K.; Tran, M. T.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vázquez Sierra, C.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; de Vries, J. A.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Websdale, D.; Weiden, A.; Whitehead, M.; Wiedner, D.; Wilkinson, G.; Wilkinson, M.; Williams, M.; Williams, M. P.; Williams, M.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wright, S.; Wyllie, K.; Xie, Y.; Xu, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, L.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.

    2015-08-01

    A search for decays is performed using 3 .0 fb1- of pp collision data recorded by the LHCb experiment during 2011 and 2012. The f 0(980) meson is reconstructed through its decay to the π + π - final state in the mass window 900 MeV /c 2 < m( π + π -) < 1080 MeV /c 2. No significant signal is observed. The first upper limits on the branching fraction of are set at 90 % (95 %) confidence level. [Figure not available: see fulltext.

  12. Decay of relativistic hypernuclei

    SciTech Connect

    Majlingova, Olga

    2008-05-12

    The contribution is focused on the analysis of the hypernuclei decay. Hypernuclei, nuclei composed of nucleons and hyperon, enable us to more precise study baryon-baryon interaction, both weak and strong. Several experiments for study new hypernuclear objects are presently taking data or are planned in several laboratories in Italy, Germany, Russia, Japan and USA. The aim of the contribution is the introduction the catalogue of all possible decays of light hypernuclei (A{<=}12). Created catalogue could be exploited for planning next experiments.

  13. Solvent interaction with the (2p3s) Rydberg state of hexamethylenetetramine: Energetics and relaxation dynamics

    NASA Astrophysics Data System (ADS)

    Shang, Q. Y.; Dion, C.; Bernstein, E. R.

    1994-07-01

    The (1+1) mass resolved excitation spectra are reported for the (2p3s)←(2p)2 Rydberg transition of the tricyclic, high symmetry molecule hexamethylenetetramine [HMT (C6H12N4)] and its van der Waals clusters. The solvent molecules employed include both nonpolar (Ar, CH4) and polar (NH3, CH3OCH3) species. HMT and its clusters are generated and cooled in a supersonic expansion. The observed electronic transition is assigned as T2←A1 within the Td print group. A transition blue shift of 52 cm-1 for each Ar atom and 65 cm-1 for each methane molecule in the HMT van der Waals cluster is characterized. These shifts are caused by an excited state repulsive interaction between the excited Rydberg electron and the closed shell solvent which reduces the attractive dispersion interaction between the HMT and nonpolar solvent species in the van der Waals cluster. A transition red shift of more than 600 cm-1 for NH3 and CH3OCH3 solvent/HMT clusters is observed; this large increase in interaction energy for the excited Rydberg state of HMT with respect to the ground state of HMT is associated with the delocalization of the excited electron into available (virtual) Rydberg orbitals of the solvent molecules. The interaction is characterized as an electron transfer interaction. These results and assignments are consistent with previously reported ones for DABCO/solvent clusters. Relaxation dynamics of excited HMT and its clusters are investigated via a pump/probe (ionization) technique. Relaxation of the clusters is dominated by an intersystem crossing mechanism resulting in an excited state singlet lifetime of ˜5 ns compared to a bare molecule HMT excited state lifetime of ˜1.0 μs. A triplet state of HMT lies 255 cm-1 below the first excited singlet Rydberg state as determined by two-color threshold ionization studies.

  14. Amplification of 2p as a genomic marker for transformation in lymphoma.

    PubMed

    Kwiecinska, Anna; Ichimura, Koichi; Berglund, Mattias; Dinets, Andrii; Sulaiman, Luqman; Collins, V Peter; Larsson, Catharina; Porwit, Anna; Lagercrantz, Svetlana Bajalica

    2014-09-01

    To outline further genetic mechanisms of transformation from follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL), we have performed whole genome array-CGH in 81 tumors from 60 patients [29 de novo DLBCL (dnDLBCL), 31 transformed DLBCL (tDLBCL), and 21 antecedent FL]. In 15 patients, paired tumor samples (primary FL and a subsequent tDLBCL) were available, among which three possessed more than two subsequent tumors, allowing us to follow specific genetic alterations acquired before, during, and after the transformation. Gain of 2p15-16.1 encompassing, among others, the REL, BCL11A, USP34, COMMD1, and OTX1 genes was found to be more common in the tDLBCL compared with dnDLBCL (P < 0.001). Furthermore, a high-level amplification of 2p15-16.1 was also detected in the FL stage prior to transformation, indicating its importance during the transformation event. Quantitative real-time PCR showed a higher level of amplification of REL, USP34, and COMMD1 (all involved in the NFκΒ-pathway) compared with BCL11A, which indicates that the altered genes disrupting the NFκΒ pathway may be the driver genes of transformation rather than the previously suggested BCL11A. Moreover, a 17q21.33 amplification was exclusively found in tDLBCL, never in FL (P < 0.04) or dnDLBCL, indicating an upregulation of genes of importance during the later phase of transformation. Taken together, our study demonstrates potential genomic markers for disease progression to clinically more aggressive forms. We also confirm the importance of the TP53-, CDKN2A-, and NFκΒ-pathways for the transformation from FL to DLBCL. PMID:24832791

  15. Attractor Explosions and Catalyzed Vacuum Decay

    SciTech Connect

    Green, Daniel; Silverstein, Eva; Starr, David

    2006-05-05

    We present a mechanism for catalyzed vacuum bubble production obtained by combining moduli stabilization with a generalized attractor phenomenon in which moduli are sourced by compact objects. This leads straightforwardly to a class of examples in which the Hawking decay process for black holes unveils a bubble of a different vacuum from the ambient one, generalizing the new endpoint for Hawking evaporation discovered recently by Horowitz. Catalyzed vacuum bubble production can occur for both charged and uncharged bodies, including Schwarzschild black holes for which massive particles produced in the Hawking process can trigger vacuum decay. We briefly discuss applications of this process to the population and stability of metastable vacua.

  16. Attractor explosions and catalyzed vacuum decay

    NASA Astrophysics Data System (ADS)

    Green, Daniel; Silverstein, Eva; Starr, David

    2006-07-01

    We present a mechanism for catalyzed vacuum bubble production obtained by combining moduli stabilization with a generalized attractor phenomenon in which moduli are sourced by compact objects. This leads straightforwardly to a class of examples in which the Hawking decay process for black holes unveils a bubble of a different vacuum from the ambient one, generalizing the new end point for Hawking evaporation discovered recently by Horowitz. Catalyzed vacuum bubble production can occur for both charged and uncharged bodies, including Schwarzschild black holes for which massive particles produced in the Hawking process can trigger vacuum decay. We briefly discuss applications of this process to the population and stability of metastable vacua.

  17. Decay Time of Cathodoluminescence

    ERIC Educational Resources Information Center

    Kraftmakher, Yaakov

    2009-01-01

    Simple measurements of the decay time of cathodoluminescence are described. Cathodoluminescence is used in many devices, including computer monitors, oscilloscopes, radar displays and television tubes. The experimental setup is simple and easy to build. Two oscilloscopes, a function generator, and a fast photodiode are needed for the experiments.…

  18. Chiral quirkonium decays

    NASA Astrophysics Data System (ADS)

    Fok, R.; Kribs, Graham D.

    2011-08-01

    We calculate the two-body decay rates of quirkonium states formed from quirks that acquire mass solely through electroweak symmetry breaking. We consider SU(N)ic infracolor with two flavors of quirks transforming under the electroweak group (but not QCD) of the standard model. In one case, the quirks are in a chiral representation of the electroweak group, while in the other case, a vectorlike representation. The differences in the dominant decay channels between “chiral quirkonia” versus “vectorlike quirkonia” are striking. Several chiral quirkonia states can decay into the unique two-body resonance channels WH, ZH, tt¯, tb¯/bt¯, and γH, which never dominate for vectorlike quirkonia. Additionally, the channels WW, WZ, ZZ, and Wγ, are shared among both chiral and vectorlike quirkonia. Resonances of dileptons or light quarks (dijets) can dominate for some vectorlike quirkonia states throughout their mass range, while these modes never dominate for chiral quirkonia unless the decays into pairs of gauge or Higgs bosons are kinematically forbidden.

  19. Chiral Quirkonium Decays

    SciTech Connect

    Fok, R.; Kribs, Graham D.; /Fermilab

    2011-06-01

    We calculate the two-body decay rates of quirkonium states formed from quirks that acquire mass solely through electroweak symmetry breaking. We consider SU(N){sub ic} infracolor with two flavors of quirks transforming under the electroweak group (but not QCD) of the standard model. In one case, the quirks are in a chiral representation of the electroweak group, while in the other case, a vectorlike representation. The differences in the dominant decay channels between 'chiral quirkonia' versus 'vectorlike quirkonia' are striking. Several chiral quirkonia states can decay into the unique two-body resonance channels WH, ZH, t{bar t}, t{bar b}/b{bar t}, and {gamma}H, which never dominate for vectorlike quirkonia. Additionally, the channels WW, WZ, ZZ, and W{gamma}, are shared among both chiral and vectorlike quirkonia. Resonances of dileptons or light quarks (dijets) can dominate for some vectorlike quirkonia states throughout their mass range, while these modes never dominate for chiral quirkonia unless the decays into pairs of gauge or Higgs bosons are kinematically forbidden.

  20. Magnetorotational decay instability in Keplerian disks.

    PubMed

    Shtemler, Yuri; Liverts, Edward; Mond, Michael

    2013-12-01

    The saturation of the magnetorotational instability (MRI) in thin Keplerian disks through three-wave resonant interactions is introduced and discussed. That mechanism is a natural generalization of the fundamental decay instability discovered five decades ago for infinite, homogeneous, and immovable plasmas. The decay instability relies on the energy transfer from the MRI to stable slow Alfvén-Coriolis as well as magnetosonic waves. A second-order forced Duffing amplitude equation for the initially unstable MRI as well as two first-order equations for the other two waves are derived. The solutions of those equations exhibit bounded bursty nonlinear oscillations for the MRI as well as unbounded growth for the linearly stable slow Alfvén-Coriolis and magnetosonic perturbations, thus giving rise to the magnetorotational decay instability. PMID:24476249

  1. Anatomy of decays

    NASA Astrophysics Data System (ADS)

    Bel, Lennaert; De Bruyn, Kristof; Fleischer, Robert; Mulder, Mick; Tuning, Niels

    2015-07-01

    The decays B {/d 0} → D {/d -} D {/d +} and B {/s 0} → D {/s -} D {/s +} probe the CP-violating mixing phases ϕ d and ϕ s , respectively. The theoretical uncertainty of the corresponding determinations is limited by contributions from penguin topologies, which can be included with the help of the U-spin symmetry of the strong interaction. We analyse the currently available data for B {/d, s 0} → D {/d, s -} D {/d, s +} decays and those with similar dynamics to constrain the involved non-perturbative parameters. Using further information from semileptonic B {/d 0} → D {/d -} ℓ + ν ℓ decays, we perform a test of the factorisation approximation and take non-factorisable SU(3)-breaking corrections into account. The branching ratios of the B {/d 0} → D {/d -} D {/d +}, B {/s 0} → D {/s -} D {/d +} and B {/s 0} → D {/s -} D {/s +}, B {/d 0} → D {/d -} D {/s +} decays show an interesting pattern which can be accommodated through significantly enhanced exchange and penguin annihilation topologies. This feature is also supported by data for the B {/s 0} → D {/d -} D {/d +} channel. Moreover, there are indications of potentially enhanced penguin contributions in the B {/d 0} → D {/d -} D {/d +} and B {/s 0} → D {/s -} D {/s +} decays, which would make it mandatory to control these effects in the future measurements of ϕ d and ϕ s . We discuss scenarios for high-precision measurements in the era of Belle II and the LHCb upgrade.

  2. The excitation and collisional deactivation of metastable N/2P/ atoms in auroras

    NASA Technical Reports Server (NTRS)

    Zipf, E. C.; Espy, P. J.; Boyle, C. F.

    1980-01-01

    The concentration and altitude distribution of metastable N(2P) atoms was measured in a diffuse IBC II(+) auroral arc. The dominant N(2P) source is shown to be the dissociative excitation of N2 by electron impact with a minor contribution from the dissociative recombination of N2(+) ions. The possibility that an ion-molecule process involving atomic oxygen and vibrationally excited N2(+) ions is a significant N(2P) source is examined. Values for the proportional yield of N(+), N(2P), N(2D), and N(4S) atoms from electron-impact dissociation of N2 under optically thick conditions are given.

  3. State-selective enhanced production of positive ions and excited neutral fragments of gaseous CH2Cl2 following Cl 2p core-level photoexcitation

    NASA Astrophysics Data System (ADS)

    Lu, K. T.; Chen, J. M.; Lee, J. M.; Haw, S. C.; Chen, S. A.; Liang, Y. C.; Chen, S. W.

    2010-09-01

    Following photoexcitation of Cl2p electrons to various resonances, the dissociation dynamics of ionic and excited neutral fragments of gaseous CH2Cl2 was investigated by combined measurements of photon-induced ionic dissociation, x-ray absorption, and uv-visible dispersed fluorescence. The Cl2p core-to-Rydberg excitations near the ionization threshold produce a notable enhancement of excited neutral fragments (C* and CH*), which is attributed to the contribution from a shake-modified resonant Auger decay and postcollision interaction. The excitation Cl2p→10a1* induces an enhanced yield of CH2+, possibly originating from fast dissociation via a strongly repulsive surface. The experimental results provide insight into the dissociation dynamics of ionic and excited neutral fragment production following core-level excitation.

  4. Storing keV negative ions for an hour: the lifetime of the metastable ^(2)P((1/2)^(o)) level in ^(32)S^(-).

    PubMed

    Bäckström, E; Hanstorp, D; Hole, O M; Kaminska, M; Nascimento, R F; Blom, M; Björkhage, M; Källberg, A; Löfgren, P; Reinhed, P; Rosén, S; Simonsson, A; Thomas, R D; Mannervik, S; Schmidt, H T; Cederquist, H

    2015-04-10

    We use a novel electrostatic ion storage ring to measure the radiative lifetime of the upper level in the 3p^{5} ^{2}P_{1/2}^{o}→3p^{5} ^{2}P_{3/2}^{o} spontaneous radiative decay in ^{32}S^{-} to be 503±54  sec. This is by orders of magnitude the longest lifetime ever measured in a negatively charged ion. Cryogenic cooling of the storage ring gives a residual-gas pressure of a few times 10^{-14} mbar at 13 K and storage of 10 keV sulfur anions for more than an hour. Our experimental results differ by 1.3σ from the only available theoretical prediction [P. Andersson et al., Phys. Rev. A 73, 032705 (2006)]. PMID:25910117

  5. Lifetime of inner-shell hole states of Ar (2p) and Kr (3d) using equation-of-motion coupled cluster method

    SciTech Connect

    Ghosh, Aryya; Vaval, Nayana; Pal, Sourav

    2015-07-14

    Auger decay is an efficient ultrafast relaxation process of core-shell or inner-shell excited atom or molecule. Generally, it occurs in femto-second or even atto-second time domain. Direct measurement of lifetimes of Auger process of single ionized and double ionized inner-shell state of an atom or molecule is an extremely difficult task. In this paper, we have applied the highly correlated complex absorbing potential-equation-of-motion coupled cluster (CAP-EOMCC) approach which is a combination of CAP and EOMCC approach to calculate the lifetime of the states arising from 2p inner-shell ionization of an Ar atom and 3d inner-shell ionization of Kr atom. We have also calculated the lifetime of Ar{sup 2+}(2p{sup −1}3p{sup −1}) {sup 1}D, Ar{sup 2+}(2p{sup −1}3p{sup −1}) {sup 1}S, and Ar{sup 2+}(2p{sup −1}3s{sup −1}) {sup 1}P double ionized states. The predicted results are compared with the other theoretical results as well as experimental results available in the literature.

  6. Precision measurement of the branching fractions of the 5 p 1/2 2P state in +88Sr with a single ion in a microfabricated surface trap

    NASA Astrophysics Data System (ADS)

    Likforman, Jean-Pierre; Tugayé, Vincent; Guibal, Samuel; Guidoni, Luca

    2016-05-01

    We measured the branching fractions for the decay of the 5 p 1/2 2P state of +88Sr by applying a recently demonstrated photon-counting sequential method [M. Ramm, T. Pruttivarasin, M. Kokish, I. Talukdar, and H. Häffner, Phys. Rev. Lett. 111, 023004 (2013), 10.1103/PhysRevLett.111.023004] to a single ion laser cooled in a microfabricated surface trap. The branching fraction for the decay into the 5 s 1/2 2S ground level was found to be p =0.9449 (5 ) . This result is in good agreement with recent theoretical calculations but disagrees with previous experimental measurements, however affected by a one-order-of-magnitude larger uncertainty. This experiment demonstrates that microtrap technology is also applicable in the domain of precision measurements and spectroscopy.

  7. Rare Down Quark Decays

    NASA Astrophysics Data System (ADS)

    Tung, Kwong-Kwai Humphrey

    1992-01-01

    The rare decays bto sX are sensitive to strong interaction corrections. The effects can be estimated by a renormalization group technique which requires the evaluation of QCD mixing among effective operators. In the dimensional reduction and the naive dimensional regularization methods, there are discrepancies in evaluating the QCD mixing of the four-quark operators with the bto sgamma and bto s+gluon dipole operators. In this thesis, the problem is investigated by considering the contributions of the epsilon -scalar field and the epsilon -dimensional operators that distinguish between the two methods. The discrepancies are shown to come from the epsilon-dimensional four-quark operators in dimensional reduction and not from the epsilon -scalar field. In the decay bto sl^+l^ -, the intermediate of cc pairs in the charm-penguin diagram can form the resonance states J/psi and psi^'. In the published literature, there is a sign discrepancy in the Breit-Wigner amplitude for the resonance effects. Here, the sign difference is settled by considering the unitarity limit of the amplitude in the Argand diagram. The effects of the resonances are quite substantial on the invariant mass spectrum for this decay. However, they are shown to be negligible on the dilepton energy spectrum below 0.95 GeV. The energy spectrum is, thus, more useful than the invariant mass spectrum for measurements of the top -quark mass. The decays Bto K^*X are well modeled by the quark-level decays bto sX. In the quark model, the hadronization is done using a nonrelativistic wave function. In the decay B to K^*gamma, the large K ^* recoil creates an uncertainty in calculating the branching ratio using the quark model. The problem is explored by considering other meson processes where data exist. The data on the pi form factor and the omegapi^0 transition form factor suggest the necessity to retain relativistic spinor and meson normalizations in the quark -model; however, the data do not resolve the

  8. B Decays Involving Light Mesons

    SciTech Connect

    Eschrich, Ivo Gough; /UC, Irvine

    2007-01-09

    Recent BABAR results for decays of B-mesons to combinations of non-charm mesons are presented. This includes B decays to two vector mesons, B {yields} {eta}{prime}({pi}, K, {rho}) modes, and a comprehensive Dalitz Plot analysis of B {yields} KKK decays.

  9. Deactivation of Ni2P/SiO2 catalyst in hydrodechlorination of chlorobenzene

    NASA Astrophysics Data System (ADS)

    Chen, Jixiang; Ci, Donghui; Yang, Qing; Li, Kelun

    2014-11-01

    The deactivation of the Ni2P/SiO2 catalyst in the hydrodechlorination of chlorobenzene was studied. To better illuminate the reasons for the deactivation, the effect of HCl on the structure and activity of Ni2P/SiO2 was investigated. For comparison, the deactivation of the Ni/SiO2 catalyst was also involved. It was found that the Ni2P particles possessed good resistance to HCl poison and to sintering, which is ascribed to the electron-deficiency of Niδ+(0 < δ < 1) site in Ni2P. Acted as the Lewis and Brönsted acid site, the Niδ+ site and the Psbnd OH group on Ni2P/SiO2 catalyzed the formation of the carbonaceous deposit that was difficultly eliminated by hydrogenation. The carbonaceous deposit covered the active sites and might also induce a decrease in the Ni2P crystallinity, subsequently leading to the Ni2P/SiO2 deactivation. Different from Ni2P/SiO2, Ni/SiO2 was mainly deactivated by the chlorine poison and the sintering of nickel crystallites.

  10. A Study of Perkins 2P1 Graduation Performance Rates at Virginia Western Community College

    ERIC Educational Resources Information Center

    Archer, J. Andrew.

    2006-01-01

    "2P1" is the Carl Perkins label for an institution's graduation performance rate. Systems receiving Perkins funds, like Virginia's 23 community colleges, are expected to meet a federally approved 2P1 target rate. For the 3-year period 1999-2001 Virginia Western Community College (VWCC) was one of seven community colleges in the VCCS (Virginia…

  11. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... § 1917.2(p)). 2 The Department of Transportation and the United States Coast Guard apply requirements related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR... 29 Labor 7 2010-07-01 2010-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section...

  12. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... § 1917.2(p)). 2 The Department of Transportation and the United States Coast Guard apply requirements related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR... 29 Labor 7 2011-07-01 2011-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section...

  13. Peer-to-Peer (P2P) Knowledge, Use, and Attitudes of Academic Librarians

    ERIC Educational Resources Information Center

    Hendrix, Dean

    2007-01-01

    To assess their knowledge, use, and attitudes regarding peer-to-peer (P2P) applications, this study surveyed academic librarians (n = 162) via a mail-in survey. Correlations between the sample characteristics (age, gender, year of MLS, type of library job) and P2P knowledge, use, and attitudes were also explored. Overall, academic librarians…

  14. PyDecay/GraphPhys: A Unified Language and Storage System for Particle Decay Process Descriptions

    SciTech Connect

    Dunietz, Jesse N.; /MIT /SLAC

    2011-06-22

    To ease the tasks of Monte Carlo (MC) simulation and event reconstruction (i.e. inferring particle-decay events from experimental data) for long-term BaBar data preservation and analysis, the following software components have been designed: a language ('GraphPhys') for specifying decay processes, common to both simulation and data analysis, allowing arbitrary parameters on particles, decays, and entire processes; an automated visualization tool to show graphically what decays have been specified; and a searchable database storage mechanism for decay specifications. Unlike HepML, a proposed XML standard for HEP metadata, the specification language is designed not for data interchange between computer systems, but rather for direct manipulation by human beings as well as computers. The components are interoperable: the information parsed from files in the specification language can easily be rendered as an image by the visualization package, and conversion between decay representations was implemented. Several proof-of-concept command-line tools were built based on this framework. Applications include building easier and more efficient interfaces to existing analysis tools for current projects (e.g. BaBar/BESII), providing a framework for analyses in future experimental settings (e.g. LHC/SuperB), and outreach programs that involve giving students access to BaBar data and analysis tools to give them a hands-on feel for scientific analysis.

  15. Decay Dynamics of Tumors

    PubMed Central

    2016-01-01

    The fractional cell kill is a mathematical expression describing the rate at which a certain population of cells is reduced to a fraction of itself. We investigate the mathematical function that governs the rate at which a solid tumor is lysed by a cell population of cytotoxic lymphocytes. We do it in the context of enzyme kinetics, using geometrical and analytical arguments. We derive the equations governing the decay of a tumor in the limit in which it is plainly surrounded by immune cells. A cellular automaton is used to test such decay, confirming its validity. Finally, we introduce a modification in the fractional cell kill so that the expected dynamics is attained in the mentioned limit. We also discuss the potential of this new function for non-solid and solid tumors which are infiltrated with lymphocytes. PMID:27310010

  16. The effect of Li(+) ions on the luminescent properties of a single-phase white light-emitting phosphor α-Sr2P2O7:Dy(3.).

    PubMed

    Han, Bing; Li, Pengju; Zhang, Jingtao; Zhang, Jie; Xue, Yongfei; Shi, Hengzhen

    2015-05-01

    Two series of phosphors, α-Sr2(1-x)Dy2xP2O7 and α-Sr2(1-2x)Dy2xLi2xP2O7, with different x values were synthesized successfully using a conventional solid-state method at high temperature for the first time, and their luminescence properties were investigated comparatively. The effect of Li(+) ions on the luminescence properties of Dy(3+) in α-Sr2P2O7 host, including luminescence intensity, optimal doping concentration, concentration quenching mechanism, and decay behavior, was discussed in detail by considering the defect generation in α-Sr2P2O7:Dy(3+), the charge compensation of Li(+) ions and the role of Li2CO3 as solid flux expected in phosphors. The obtained excitation and emission spectra indicate that these as-prepared phosphors can be excited by ultraviolet light and show white light emission due to the combination of the (4)F9/2→(6)H15/2 and (4)F9/2→(6)H13/2 transitions of Dy(3+) ions. The CIE chromaticity coordinates and color correlated temperature of Dy(3+) emission in the phosphor α-Sr2(1-2x)Dy2xLi2xP2O7 (x = 0.03) with optimal fluorescence intensity was also calculated. The present work could be helpful for understanding the effect of the charge compensator (e.g. Li(+) ion) on the luminescent properties of phosphors with non-equivalent ion-displacement and the design of novel phosphors by efficiently taking advantage of charge compensator (e.g. Li(+) ion). PMID:25820378

  17. Design and Implementation of P2P Streaming Systems for Webcast

    NASA Astrophysics Data System (ADS)

    Gotoh, Yusuke; Suzuki, Kentaro; Yoshihisa, Tomoki; Kanazawa, Masanori

    Due to the recent spread of different styles of watching movies, streaming using Peer-to-Peer (P2P) technology has attracted great attention. In P2P streaming systems, to distribute the network load, since peers from which the user receives data are selected at random, clients have to wait until their desired data are delivered. Therefore, many researches are attempting to reduce the waiting time. However, due to the complexity of implementation, they usually evaluate these methods using machine simulations. In actual environments, interruption time is not always reduced by increasing the number of clients who deliver data. To evaluate the availability of P2P streaming systems, implementing a P2P streaming system is crucial. In this paper, we design and implement a P2P streaming system. With our implemented system, we consider situations in which the proposed system is effective.

  18. Convergence of Internet and TV: The Commercial Viability of P2P Content Delivery

    NASA Astrophysics Data System (ADS)

    de Boever, Jorn

    The popularity of (illegal) P2P (peer-to-peer) file sharing has a disruptive impact on Internet traffic and business models of content providers. In addition, several studies have found an increasing demand for bandwidth consuming content, such as video, on the Internet. Although P2P systems have been put forward as a scalable and inexpensive model to deliver such content, there has been relatively little economic analysis of the potentials and obstacles of P2P systems as a legal and commercial content distribution model. Many content providers encounter uncertainties regarding the adoption or rejection of P2P networks to spread content over the Internet. The recent launch of several commercial, legal P2P content distribution platforms increases the importance of an integrated analysis of the Strengths, Weaknesses, Opportunities and Threats (SWOT).

  19. Efficient Plasma Production in Low Background Neutral Pressures with the M2P2 Prototype

    NASA Technical Reports Server (NTRS)

    Ziemba, T.; Euripides, P.; Winglee, R.; Slough, J.; Giersch, L.

    2003-01-01

    Mini-Magnetospheric Plasma Propulsion (M2P2) seeks the creation of a large-scale (10 km radius) magnetic wall or bubble (i.e. a magnetosphere) by the electromagnetic inflation of a small-scale (20 cm radius) dipole magnet. The inflated magnetosphere will intercept the solar wind and thereby provide high-speed propulsion with modest power and fuel requirements due to the gain provided by the ambient medium. Magnetic field inflation is produced by the injection of plasma onto the dipole magnetic field eliminating the need for large mechanical structures and added material weight at launch. For successful inflation of the magnetic bubble a beta near unity must be achieved along the imposed dipole field. This is dependent on the plasma parameters that can be achieved with a plasma source that provide continuous operation at the desired power levels of 1 to 2 kilowatts. Over the last two years we have been developing a laboratory prototype to demonstrate the inflation of the magnetic field under space-like conditions. In this paper we will present some of the latest results from the prototype development at the University of Washington and show that the prototype can produce high ionization efficiencies while operating in near space like neutral background pressures producing electron temperatures of a few tens of electron volts. This allows for operation with propellant expenditures lower than originally estimated.

  20. NMR study of heavy fermion compound EuNi2P2

    NASA Astrophysics Data System (ADS)

    Magishi, K.; Watanabe, R.; Hisada, A.; Saito, T.; Koyama, K.; Fujiwara, T.

    2015-03-01

    We report the results of 31P-nuclear magnetic resonance (NMR) measurements on heavy fermion compound EuNi2P2 in order to investigate the magnetic properties at low temperatures from a microscopic view point. The Knight shift has a negative value in an entire temperature range, and the absolute value increases with decreasing temperature but exhibits a broad maximum around 40 K, which is similar to the behavior of the magnetic susceptibility. Also, the nuclear spin-lattice relaxation rate 1/T1 is almost constant at high temperatures above 200 K, which is reminiscent of the relaxation mechanism dominated by the interaction of the 31P nucleus with fluctuating Eu-4f moments. Below 200 K, 1/T1 gradually decreases on cooling due to the change of the valence in the Eu ion. At low temperatures, 1/T1 does not obey the Korringa relation, in contrast to typical heavy fermion compounds. The nuclear spin-spin relaxation rate 1/T2 shows the similar behavior as 1/T1 at high temperatures. But, below 50 K, 1/T2 increases upon cooling due to the development of the magnetic excitation.

  1. MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway.

    PubMed

    Raina, Deepak; Ahmad, Rehan; Chen, Dongshu; Kumar, Shailendra; Kharbanda, Surender; Kufe, Donald

    2008-12-01

    The MUC1 oncoprotein interacts with the c-Abl tyrosine kinase and blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. Mutation of the MUC1 cytoplasmic domain at Tyr-60 disrupts the MUC1-c-Abl interaction. The present results demonstrate that the MUC1(Y60F) mutant is a potent inducer of the ARF tumor suppressor. MUC1(Y60F) induces transcription of the ARF locus by a c-Abl-dependent mechanism that promotes CUL-4A-mediated nuclear export of the replication protein Cdc6. The functional significance of these findings is that MUC1(Y60F)-induced ARF expression and thereby inhibition of MDM2 results in the upregulation of p53 and the homeodomain interacting protein kinase 2 (HIPK2) serine/threonine kinase. HIPK2-mediated phosphorylation of p53 on Ser-46 was further associated with a shift from expression of the cell cycle arrest-related p21 gene to the apoptosis-related PUMA gene. We also show that the MUC1(Y60F) mutant functions as dominant negative inhibitor of tumorigenicity. These findings indicate that the oncogenic function of MUC1 is conferred by suppressing activation of the ARF-MDM2-p53 pathway. PMID:18981727

  2. Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor-Suppressive Interaction with Smurf2.

    PubMed

    Kim, Dae Gyu; Lee, Jin Young; Lee, Ji-Hyun; Cho, Ha Yeon; Kang, Beom Sik; Jang, Song-Yee; Kim, Myung Hee; Guo, Min; Han, Jung Min; Kim, Seong-Jin; Kim, Sunghoon

    2016-06-01

    AIMP2/p38 is a multifunctional tumor suppressor that normally resides in the cytosol as a scaffold protein of the multi-tRNA synthetase complex (MSC). One of the tumor-suppressive functions of AIMP2 is to facilitate ubiquitin-mediated degradation of FUSE-binding protein (FBP, FUBP1), a transcriptional activator of c-Myc. However, the mechanism by which AIMP2 functions within this pathway and its significance in tumorigenesis are uncertain. Here, we report that Smurf2 is responsible for AIMP2-mediated ubiquitination of FBP, and a mutation in AIMP2 that inhibited its nuclear interaction with Smurf2 enhanced cellular transformation and tumorigenesis in vivo Treatment of HeLa cells with TGFβ resulted in the phosphorylation of AIMP2 on S156, a residue that is exposed on the embedded GST domain of AIMP2. We further found that phospho-AIMP2 dissociated from the MSC and translocated to the nucleus, where it bound to Smurf2, enhancing ubiquitination of FBP. AIMP2 also inhibited nuclear export of Smurf2 to sustain TGFβ signaling. Collectively, these findings present a novel tumor-suppressive interaction between AIMP2 and Smurf2 and suggest that the disruption of this interaction can lead to oncogenic transformation. Cancer Res; 76(11); 3422-36. ©2016 AACR. PMID:27197155

  3. Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.

    PubMed

    Shen, Peter S; Park, Joseph; Qin, Yidan; Li, Xueming; Parsawar, Krishna; Larson, Matthew H; Cox, James; Cheng, Yifan; Lambowitz, Alan M; Weissman, Jonathan S; Brandman, Onn; Frost, Adam

    2015-01-01

    In Eukarya, stalled translation induces 40S dissociation and recruitment of the ribosome quality control complex (RQC) to the 60S subunit, which mediates nascent chain degradation. Here we report cryo-electron microscopy structures revealing that the RQC components Rqc2p (YPL009C/Tae2) and Ltn1p (YMR247C/Rkr1) bind to the 60S subunit at sites exposed after 40S dissociation, placing the Ltn1p RING (Really Interesting New Gene) domain near the exit channel and Rqc2p over the P-site transfer RNA (tRNA). We further demonstrate that Rqc2p recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of nascent chains independently of mRNA or 40S subunits. Our work uncovers an unexpected mechanism of protein synthesis, in which a protein--not an mRNA--determines tRNA recruitment and the tagging of nascent chains with carboxy-terminal Ala and Thr extensions ("CAT tails"). PMID:25554787

  4. Lifetime of the 1s2p {sup 1}P{sub 1} Excited Level in Fe{sup 24+}

    SciTech Connect

    Beiersdorfer, P; Graf, A; Harris, C L; Hwang, D Q; Neill, P A

    2002-07-02

    Measurements of the spectrum of Fe{sup 24+} in the 1.845 {angstrom} to 1.885 {angstrom} range obtained on the EBIT-I electron beam ion trap at Lawrence Livermore National Laboratory were used for determining the radiative lifetime of the ls2p {sup 1}P{sub 1} excited state. The spectrum contains electric dipole forbidden transitions at 1.855{angstrom} (''x'') and 1.868{angstrom} (''z'') whose lineshape is well represented by a Gaussian line profile and is assumed to be due primarily to Doppler and instrumental broadening. The Gaussian contribution is assumed to be the same for all lines in the spectrum. This assumption simplifies the problem when considering a more complex combination of broadening mechanisms. For allowed transitions such as 1s2p {sup 1}P{sub 1} {yields} 1s{sup 2} {sup 1}S{sub 0}, ''w'', at 1.850 {angstrom} we assume a Voigt profile. In the simplest case this combines both natural (Lorentzian) and Doppler (Gaussian) broadening effects which contribute to the width of the spectral line. With the Gaussian contribution determined from lines ''x'' and ''z'', deconvolving the Gaussian from the Voigt profile gives the natural line width. This then is directly related to the radiative lifetime of the 1s2p {sup 1}P{sub 1} excited level.

  5. Computational analysis of spiro-oxindole inhibitors of the MDM2-p53 interaction: insights and selection of novel inhibitors.

    PubMed

    Huang, Wei; Cai, Lulu; Chen, Can; Xie, Xin; Zhao, Qiong; Zhao, Xing; Zhou, Hong-yun; Han, Bo; Peng, Cheng

    2016-01-01

    Since MDM2 is an inhibitor of the p53 tumor suppressor, disrupting the MDM2-p53 interaction is a promising approach for cancer therapy. Here, we used molecular dynamics simulations followed by free energy decomposition analysis to study conformational changes in MDM2 induced by three known spiro-oxindole inhibitors. Analysis of individual energy terms suggests that van der Waals and electrostatic interactions explain much of the binding affinities of these inhibitors. Binding free energies calculated for the three inhibitors using the molecular mechanics-generalized Born surface area model were consistent with experimental data, suggesting the validity of this approach. Based on this structure-function analysis, several novel spiro-oxindole derivatives were selected and evaluated for their ability to block the MDM2-p53 interaction in vitro. These results suggest that combining in silico and experimental techniques can provide insights into the structure-function relationships of MDM2 inhibitors and guide the rational design of anticancer drugs targeting the MDM2-p53 interaction. PMID:25808617

  6. RADIATIVE PENGUIN DECAYS FROM BABAR

    SciTech Connect

    Eigen, Gerald

    2003-08-28

    Electroweak penguin decays provide a promising hunting ground for Physics beyond the Standard Model (SM). The decay B {yields} X{sub s}{gamma}, which proceeds through an electromagnetic penguin loop, already provides stringent constraints on the supersymmetric (SUSY) parameter space. The present data samples of {approx}1 x 10{sup 8} B{bar B} events allow to explore radiative penguin decays with branching fractions of the order of 10{sup -6} or less. In this brief report they discuss a study of B {yields} K*{ell}{sup +}{ell}{sup -} decay modes and a search for B {yields} {rho}({omega}){gamma} decays.

  7. Charmless b decays at CDF

    SciTech Connect

    Donega, Mauro; /Geneva U.

    2005-07-01

    The authors report on the charmless B decays measurements performed on 180 pb{sup -1} of data collected with the CDF II detector at the Fermilab Tevatron collider. This paper describes: the first observation of the decay mode B{sub s} {yields} K{sup +}K{sup -} and the measurement of the direct Cp asymmetry in the ({bar B}){sub d} {yields} K{sup {+-}}{pi}{sup {-+}} decay; the first evidence of the decay mode B{sub s} {yields} {phi}{phi} and the branching ratio and Cp asymmetry for the B{sup {+-}} {yields} {phi}K{sup {+-}} decay.

  8. Kinetics of an oxygen - iodine active medium with iodine atoms optically pumped on the 2P1/2 - 2P3/2 transition

    NASA Astrophysics Data System (ADS)

    Zagidullin, M. V.; Malyshev, M. S.; Azyazov, V. N.

    2015-08-01

    The kinetics of the processes occurring in an O2 - I2 - He - H2O gas flow in which photodissociation of molecular iodine at a wavelength close to 500 nm and excitation of atomic iodine on the 2P1/2 - 2P3/2 transition by narrow-band radiation near 1315 nm are implemented successively has been analysed. It is shown that implementation of these processes allows one to form an oxygen - iodine medium with a high degree of dissociation of molecular iodine and a relative content of singlet oxygen O2(a1Δ) exceeding 10%. Having formed a supersonic gas flow with a temperature ~100 K from this medium, one can reach a small-signal gain of about 10-2 cm-1 on the 2P1/2 - 2P3/2 transition in iodine atoms. The specific power per unit flow cross section in the oxygen - iodine laser with this active medium may reach ~100 W cm-2.

  9. Laboratory Measurements of the Fe XVII 2p-3s and 2p-3d Transitions and Comparison with Solar and Astrophysical Observations

    NASA Astrophysics Data System (ADS)

    Beiersdorfer, P.; Bitter, M.; von Goeler, S.; Hill, K. W.

    2004-07-01

    The L-shell emission spectrum of Fe XVII is measured in high-temperature laboratory plasmas, and the inferred intensities of the 3s-->2p transitions relative to those of the dominant 3d-->2p transition are compared to solar observations, as well as to observations of Capella, Procyon, Castor C, II Pegassi, and NGC 4636 with the Chandra and XMM-Newton X-ray observatories. The results from laboratory and astrophysical plasmas are in very good agreement, indicating that the collisional line formation processes found in low-density, high-temperature laboratory plasmas are a good description of those found in astrophysical plasmas. The laboratory observations disagree, however, to varying degrees with spectral modeling calculations. A review of existing laboratory measurements suggests that the intensity of the dominant 3d-->2p transition is overestimated by spectral modeling predications. By calibrating spectral models with laboratory data, especially by decreasing the strength of the dominant 3d-->2p transition, spectral models can be brought into agreement with the majority of solar and astrophysical observations. Without doing so, opacity effects may be grossly overestimated.

  10. Competing endogenous RNA networks of CYP4Z1 and pseudogene CYP4Z2P confer tamoxifen resistance in breast cancer.

    PubMed

    Zheng, Lufeng; Li, Xiaoman; Meng, Xia; Chou, Jinjiang; Hu, Jinhang; Zhang, Feng; Zhang, Zhiting; Xing, Yingying; Liu, Yu; Xi, Tao

    2016-05-15

    Patients with estrogen receptor α (ERα)-positive breast cancer can be treated with endocrine therapy using anti-estrogens such as tamoxifen; nonetheless, patients often develop resistance limiting the success of breast cancer treatment. The potential mechanisms remain elusive. In detail, many miRNAs have been associated with breast cancer tamoxifen resistance, but no studies have addressed the role of miRNA-mediated competitive endogenous RNAs network (ceRNET) in tamoxifen resistance. The ceRNET between CYP4Z1 and pseudogene CYP4Z2P has been revealed to promote breast cancer angiogenesis. However, its function in tamoxifen resistance remains unclear. Here we report CYP4Z1 and CYP4Z2P were downregulated in MCF-7 cells compared with tamoxifen-resistant MCF-7-TamR cells. Enforced upregulation of CYP4Z1- or CYP4Z2P-3'UTR level renders MCF-7 Cells resistant to tamoxifen. We find that overexpression of CYP4Z1- or CYP4Z2P-3'UTR enhances the transcriptional activity of ERα through the activation of ERα phosphorylation. Furthermore, we find that CYP4Z1- and CYP4Z2P-3'UTRs increase ERα activity dependent on cyclin-dependent kinase 3 (CDK3). Reporter gene and western blot assays revealed that CYP4Z1- and CYP4Z2P-3'UTRs act as CDK3 ceRNAs. More importantly, the blocking of CYP4Z1- and CYP4Z2P-3'UTRs reversed tamoxifen resistance in MCF-7-TamR cells. Our data demonstrates that the ceRNET between CYP4Z1 and pseudogene CYP4Z2P acts as a sub-ceRNET to promote CDK3 expression in ER-positive breast cancer and is a potential therapeutic target for treatment of tamoxifen-resistant breast cancer. PMID:26980484

  11. P2P Technology for High-Performance Computing: An Overview

    NASA Technical Reports Server (NTRS)

    Follen, Gregory J. (Technical Monitor); Berry, Jason

    2003-01-01

    The transition from cluster computing to peer-to-peer (P2P) high-performance computing has recently attracted the attention of the computer science community. It has been recognized that existing local networks and dedicated clusters of headless workstations can serve as inexpensive yet powerful virtual supercomputers. It has also been recognized that the vast number of lower-end computers connected to the Internet stay idle for as long as 90% of the time. The growing speed of Internet connections and the high availability of free CPU time encourage exploration of the possibility to use the whole Internet rather than local clusters as massively parallel yet almost freely available P2P supercomputer. As a part of a larger project on P2P high-performance computing, it has been my goal to compile an overview of the 2P2 paradigm. I have studied various P2P platforms and I have compiled systematic brief descriptions of their most important characteristics. I have also experimented and obtained hands-on experience with selected P2P platforms focusing on those that seem promising with respect to P2P high-performance computing. I have also compiled relevant literature and web references. I have prepared a draft technical report and I have summarized my findings in a poster paper.

  12. Solution structure of the ubiquitin-binding domain in Swa2p from Saccharomyces cerevisiae.

    PubMed

    Chim, Nicholas; Gall, Walter E; Xiao, Jing; Harris, Mark P; Graham, Todd R; Krezel, Andrzej M

    2004-03-01

    The SWA2/AUX1 gene has been proposed to encode the Saccharomyces cerevisiae ortholog of mammalian auxilin. Swa2p is required for clathrin assembly/dissassembly in vivo, thereby implicating it in intracellular protein and lipid trafficking. While investigating the 287-residue N-terminal region of Swa2p, we found a single stably folded domain between residues 140 and 180. Using binding assays and structural analysis, we established this to be a ubiquitin-associated (UBA) domain, unidentified by bioinformatics of the yeast genome. We determined the solution structure of this Swa2p domain and found a characteristic three-helix UBA fold. Comparisons of structures of known UBA folds reveal that the position of the third helix is quite variable. This helix in Swa2p UBA contains a bulkier tyrosine in place of smaller residues found in other UBAs and cannot pack as close to the second helix. The molecular surface of Swa2p UBA has a mostly negative potential, with a single hydrophobic surface patch found also in the UBA domains of human protein, HHR23A. The presence of a UBA domain implicates Swa2p in novel roles involving ubiquitin and ubiquitinated substrates. We propose that Swa2p is a multifunctional protein capable of recognizing several proteins through its protein-protein recognition domains. PMID:14997574

  13. Functional Diversification of Fungal Glutathione Transferases from the Ure2p Class

    PubMed Central

    Thuillier, Anne; Ngadin, Andrew A.; Thion, Cécile; Billard, Patrick; Jacquot, Jean-Pierre; Gelhaye, Eric; Morel, Mélanie

    2011-01-01

    The glutathione-S-transferase (GST) proteins represent an extended family involved in detoxification processes. They are divided into various classes with high diversity in various organisms. The Ure2p class is especially expanded in saprophytic fungi compared to other fungi. This class is subdivided into two subclasses named Ure2pA and Ure2pB, which have rapidly diversified among fungal phyla. We have focused our analysis on Basidiomycetes and used Phanerochaete chrysosporium as a model to correlate the sequence diversity with the functional diversity of these glutathione transferases. The results show that among the nine isoforms found in P. chrysosporium, two belonging to Ure2pA subclass are exclusively expressed at the transcriptional level in presence of polycyclic aromatic compounds. Moreover, we have highlighted differential catalytic activities and substrate specificities between Ure2pA and Ure2pB isoforms. This diversity of sequence and function suggests that fungal Ure2p sequences have evolved rapidly in response to environmental constraints. PMID:22164343

  14. Identification of L1 ORF2p sequence important to retrotransposition using Bipartile Alu retrotransposition (BAR)

    PubMed Central

    Christian, Claiborne M.; deHaro, Dawn; Kines, Kristine J.; Sokolowski, Mark; Belancio, Victoria P.

    2016-01-01

    Long Interspersed Element 1 (LINE-1 or L1) is capable of causing genomic instability through the activity of the L1 ORF2 protein (ORF2p). This protein contains endonuclease (EN) and reverse transcriptase (RT) domains that are necessary for the retrotransposition of L1 and the Short Interspersed Element (SINE) Alu. The functional importance of approximately 50% of the ORF2p molecule remains unknown, but some of these sequences could play a role in retrotransposition, or be necessary for the enzymatic activities of the EN and/or RT domains. Conventional approaches using the full-length, contiguous ORF2p make it difficult to study the involvement of these unannotated sequences in the function of L1 ORF2p. Our lab has developed a Bipartile Alu Retrotransposition (BAR) assay that relies on separate truncated ORF2p fragments: an EN-containing and an RT-containing fragment. We validated the utility of this method for studying the ORF2p function in retrotransposition by assessing the effect of expression levels and previously characterized mutations on BAR. Using BAR, we identified two pairs of amino acids important for retrotransposition, an FF and a WD. The WD appears to play a role in cDNA synthesis by the ORF2p molecule, despite being outside the canonical RT domain. PMID:27095191

  15. Identification of L1 ORF2p sequence important to retrotransposition using Bipartile Alu retrotransposition (BAR).

    PubMed

    Christian, Claiborne M; deHaro, Dawn; Kines, Kristine J; Sokolowski, Mark; Belancio, Victoria P

    2016-06-01

    Long Interspersed Element 1 (LINE-1 or L1) is capable of causing genomic instability through the activity of the L1 ORF2 protein (ORF2p). This protein contains endonuclease (EN) and reverse transcriptase (RT) domains that are necessary for the retrotransposition of L1 and the Short Interspersed Element (SINE) Alu. The functional importance of approximately 50% of the ORF2p molecule remains unknown, but some of these sequences could play a role in retrotransposition, or be necessary for the enzymatic activities of the EN and/or RT domains. Conventional approaches using the full-length, contiguous ORF2p make it difficult to study the involvement of these unannotated sequences in the function of L1 ORF2p. Our lab has developed a Bipartile Alu Retrotransposition (BAR) assay that relies on separate truncated ORF2p fragments: an EN-containing and an RT-containing fragment. We validated the utility of this method for studying the ORF2p function in retrotransposition by assessing the effect of expression levels and previously characterized mutations on BAR. Using BAR, we identified two pairs of amino acids important for retrotransposition, an FF and a WD. The WD appears to play a role in cDNA synthesis by the ORF2p molecule, despite being outside the canonical RT domain. PMID:27095191

  16. Feeding and decay of superdeformed states

    SciTech Connect

    Khoo, T.L.; Lauritsen, T.; Ahmad, I.; Carpenter, M.P.; Fernandez, P.B.; Janssens, R.V.F.; Moore, E.F.; Wolfs, F.L.H.; Benet, Ph.; Daly, P.J.; Beard, K.B.; Garg, U.; Ye, D.; Drigert, M.W.

    1992-12-31

    The mechanisms for feeding and decay of superdeformed (SD) bands are examined. Data connected with both processes in {sup 192}Hg are compared with model calculations. The calculations successfully reproduce the data, suggesting that the mechanisms for both processes are understood. Constraints on the energy of the SD band energies and on the well-depths at low and high spins have been obtained. At the point of decay around spin 10, we suggest that the SD band is 3.3--4.3 MeV above the normal yrast line and that the well depths at spin 10 and 40 are 0.5--1.3 and 3.5--4.5 MeV, respectively.

  17. Feeding and decay of superdeformed states

    SciTech Connect

    Khoo, T.L.; Lauritsen, T.; Ahmad, I.; Carpenter, M.P.; Fernandez, P.B.; Janssens, R.V.F.; Moore, E.F.; Wolfs, F.L.H. ); Benet, Ph.; Daly, P.J. ); Beard, K.B.; Garg, U.; Ye, D. ); Drigert, M.W. )

    1992-01-01

    The mechanisms for feeding and decay of superdeformed (SD) bands are examined. Data connected with both processes in [sup 192]Hg are compared with model calculations. The calculations successfully reproduce the data, suggesting that the mechanisms for both processes are understood. Constraints on the energy of the SD band energies and on the well-depths at low and high spins have been obtained. At the point of decay around spin 10, we suggest that the SD band is 3.3--4.3 MeV above the normal yrast line and that the well depths at spin 10 and 40 are 0.5--1.3 and 3.5--4.5 MeV, respectively.

  18. Prompt proton decay in the vicinity of {sup 56}Ni

    SciTech Connect

    Johansson, E. K.; Rudolph, D.; Andersson, L-L.; Fahlander, C.; Rietz, R. du; Torres, D. A.; Carpenter, M. P.; Seweryniak, D.; Zhu, S.; Charity, R. J.; Chiara, C. J.; Hoel, C.; Pechenaya, O. L.; Reviol, W.; Sarantites, D. G.; Sobotka, L. G.; Ekman, J.

    2007-11-30

    A new decay mode, the so called prompt proton decay, was discovered in 1998. It has since proven to be an important decay mechanism for several neutron deficient nuclei in the A{approx}60 region. To measure with high accuracy the energies and angular distributions of these protons, a state-of-the-art charged particle detector--LuWuSiA--was developed. It was first utilized during a fusion-evaporation reaction experiment performed at Argonne National Laboratory, U.S.A. In this contribution, the characteristics of the prompt proton decay are discussed along with the special features of LuWuSiA as well as a revisit to the prompt proton decay in {sup 58}Cu.

  19. Research of trust model in P2P network based on trusted computing

    NASA Astrophysics Data System (ADS)

    Li, Rong; Li, Lei

    2013-03-01

    In order to strengthen the security of P2P networks, it is necessary to build trust relationships between nodes of networks. However, the traditional trust evaluation models can't resist the attacks of Pseudospoofing and Pseudostheft effectively. To resolve the problems, in this paper, the trusted computing method is introduced into P2P networks, and an idea of group trust model based on trusted computing methods is proposed. In the process of trust evaluation, the model can realize the anonymous attestation of the node body, which improves the creditability of trust relationships between nodes and resolves the security problems of P2P networks.

  20. Molecular physiology of pH-sensitive background K(2P) channels.

    PubMed

    Lesage, Florian; Barhanin, Jacques

    2011-12-01

    Background K(2P) channels are tightly regulated by different stimuli including variations of external and internal pH. pH sensitivity relies on proton-sensing residues that influence channel gating and activity. Gene inactivation in the mouse is a revealing implication of K(2P) channels in many physiological functions ranging from hormone secretion to central respiratory adaptation. Surprisingly, only a few phenotypic traits of these mice have yet been directly related to the pH sensitivity of K(2P) channels. PMID:22170960

  1. Dynamic alignment and selective decay in MHD

    NASA Technical Reports Server (NTRS)

    Matthaeus, W. H.; Montgomery, D.

    1983-01-01

    Under some circumstances, incompressible magnetohydrodynamic turbulence will evolve toward a state in which the velocity fields and magnetic fields are aligned or anti-aligned. We propose a mechanism for this effect and illustrate with numerical computations. Under some other circumstances, the energy appears to decay selectively toward a minimum energy state in which the kinetic energy has disappeared. It has not been possible so far to identify a boundary in the phase space which divides the two regimes.

  2. Molecular Aspects of Structure, Gating, and Physiology of pH-Sensitive Background K2P and Kir K+-Transport Channels

    PubMed Central

    Sepúlveda, Francisco V.; Pablo Cid, L.; Teulon, Jacques; Niemeyer, María Isabel

    2015-01-01

    K+ channels fulfill roles spanning from the control of excitability to the regulation of transepithelial transport. Here we review two groups of K+ channels, pH-regulated K2P channels and the transport group of Kir channels. After considering advances in the molecular aspects of their gating based on structural and functional studies, we examine their participation in certain chosen physiological and pathophysiological scenarios. Crystal structures of K2P and Kir channels reveal rather unique features with important consequences for the gating mechanisms. Important tasks of these channels are discussed in kidney physiology and disease, K+ homeostasis in the brain by Kir channel-equipped glia, and central functions in the hearing mechanism in the inner ear and in acid secretion by parietal cells in the stomach. K2P channels fulfill a crucial part in central chemoreception probably by virtue of their pH sensitivity and are central to adrenal secretion of aldosterone. Finally, some unorthodox behaviors of the selectivity filters of K2P channels might explain their normal and pathological functions. Although a great deal has been learned about structure, molecular details of gating, and physiological functions of K2P and Kir K+-transport channels, this has been only scratching at the surface. More molecular and animal studies are clearly needed to deepen our knowledge. PMID:25540142

  3. Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.

    PubMed

    Sepúlveda, Francisco V; Pablo Cid, L; Teulon, Jacques; Niemeyer, María Isabel

    2015-01-01

    K(+) channels fulfill roles spanning from the control of excitability to the regulation of transepithelial transport. Here we review two groups of K(+) channels, pH-regulated K2P channels and the transport group of Kir channels. After considering advances in the molecular aspects of their gating based on structural and functional studies, we examine their participation in certain chosen physiological and pathophysiological scenarios. Crystal structures of K2P and Kir channels reveal rather unique features with important consequences for the gating mechanisms. Important tasks of these channels are discussed in kidney physiology and disease, K(+) homeostasis in the brain by Kir channel-equipped glia, and central functions in the hearing mechanism in the inner ear and in acid secretion by parietal cells in the stomach. K2P channels fulfill a crucial part in central chemoreception probably by virtue of their pH sensitivity and are central to adrenal secretion of aldosterone. Finally, some unorthodox behaviors of the selectivity filters of K2P channels might explain their normal and pathological functions. Although a great deal has been learned about structure, molecular details of gating, and physiological functions of K2P and Kir K(+)-transport channels, this has been only scratching at the surface. More molecular and animal studies are clearly needed to deepen our knowledge. PMID:25540142

  4. Rare B Decays

    SciTech Connect

    Jackson, P.D.; /Victoria U.

    2006-02-24

    Recent results from Belle and BaBar on rare B decays involving flavor-changing neutral currents or purely leptonic final states are presented. Measurements of the CP asymmetries in B {yields} K*{gamma} and b {yields} s{gamma} are reported. Also reported are updated limits on B{sup +} {yields} K{sup +}{nu}{bar {nu}}, B{sup +} {yields} {tau}{sup +}{nu}, B{sup +} {yields} {mu}{sup +}{nu} and the recent measurement of B {yields} X{sub s}{ell}{sup +}{ell}{sup -}.

  5. Hunting for the Xb via radiative decays

    NASA Astrophysics Data System (ADS)

    Li, Gang; Wang, Wei

    2014-06-01

    In this paper, we study radiative decays of Xb, the counterpart of the famous X (3872) in the bottomonium-sector as a candidate for meson-meson molecule, into the γϒ (nS) (n = 1 , 2 , 3). Since it is likely that the Xb is below the BBbar* threshold and the mass difference between the neutral and charged bottom meson is small compared to the binding energy of the Xb, the isospin violating decay mode Xb → ϒ (nS)π+π- would be greatly suppressed. This will promote the importance of the radiative decays. We use the effective Lagrangian based on the heavy quark symmetry to explore the rescattering mechanism and calculate the partial widths. Our results show that the partial widths into γϒ (nS) are about 1 keV, and thus the branching fractions may be sizeable, considering the fact the total width may also be smaller than a few MeV like the X (3872). These radiative decay modes are of great importance in the experimental search for the Xb particularly at hadron collider. An observation of the Xb will provide a deeper insight into the exotic hadron spectroscopy and is helpful to unravel the nature of the states connected by the heavy quark symmetry.

  6. 49 CFR 178.33 - Specification 2P; inner nonrefillable metal receptacles.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Specification 2P; inner nonrefillable metal receptacles. 178.33 Section 178.33 Transportation Other Regulations Relating to Transportation (Continued... nonrefillable metal receptacles....

  7. 49 CFR 178.33 - Specification 2P; inner nonrefillable metal receptacles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Specification 2P; inner nonrefillable metal receptacles. 178.33 Section 178.33 Transportation Other Regulations Relating to Transportation (Continued... nonrefillable metal receptacles....

  8. 49 CFR 178.33 - Specification 2P; inner nonrefillable metal receptacles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Specification 2P; inner nonrefillable metal receptacles. 178.33 Section 178.33 Transportation Other Regulations Relating to Transportation (Continued... nonrefillable metal receptacles....

  9. 49 CFR 178.33 - Specification 2P; inner nonrefillable metal receptacles.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Specification 2P; inner nonrefillable metal receptacles. 178.33 Section 178.33 Transportation Other Regulations Relating to Transportation (Continued... nonrefillable metal receptacles....

  10. High pressure studies of the phase transition in the ferroelectric Sn2P2S6

    NASA Astrophysics Data System (ADS)

    Dzhavadov, Leonid N.; Ryzhov, Valentin N.

    2016-06-01

    We apply a method of pulse-adiabatic modulation of pressure to obtain heat capacity and thermal expansion of ferroelectric Sn2P2S6 in the vicinity of the second order phase transition at pressures to 5 kbar. The phase transition in Sn2P2S6 does not change its nature and stays second order in the whole range of pressure currently studied. The earlier conclusion on the tricritical features of the phase transition in Sn2P2S6 cannot be confirmed. Discontinuities of heat capacity and thermal expansion perfectly fit the Ehrenfest equation that expected in the mean field theories. An excellent performance of the Ehrenfest formula in a wide range of pressures establishes phase transition in Sn2P2S6 as an almost ideal mean field phase transition.

  11. 49 CFR 178.33 - Specification 2P; inner nonrefillable metal receptacles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification 2P; inner nonrefillable metal receptacles. 178.33 Section 178.33 Transportation Other Regulations Relating to Transportation PIPELINE AND... nonrefillable metal receptacles....

  12. 1s2s2p2 5p3 5S transition in B ii

    NASA Astrophysics Data System (ADS)

    Mannervik, S.; Cederquist, H.; Martinson, I.; Brage, T.; Froese Fischer, C.

    1987-04-01

    An experimental and theoretical study has been made of the 1s2s2p2 5P-1s2p3 5S transition in B ii. The experimental wavelength and lifetime (1323.92+/-0.07 Å and 0.65+/-0.01 ns), determined by beam-foil spectroscopy, are more than five times more accurate than previous experimental results. Our theoretical data, from multiconfiguration Hartree-Fock calculations, 1311.6 Å and 0.601 ns, are in excellent agreement with previous theoretical predictions of Beck and Nicolaides [Phys. Lett. 61A, 227 (1977)]. We have also observed the 1s2p3 5S-1s2p23s 5P transition, at 857.7+/-0.2 Å, in accord with the theoretical value 859.1 Å.

  13. Amyloid-like properties of Saccharomyces cerevisiae cell wall glucantransferase Bgl2p

    PubMed Central

    Plotnikova, Tatyana A; Gorkovskii, Anton A; Selyakh, Irina O; Galzitskaya, Oxana V; Bezsonov, Evgeniy E; Gellissen, Gerd; Kulaev, Igor S

    2008-01-01

    Glucantransferase Bgl2p is a major conserved cell wall constituent described for a wide range of yeast species. In the baker's yeast Saccharomyces cerevisiae it is the only non-covalently bound cell wall protein that cannot be released from cell walls by sequential SDS and trypsin treatment. It contains seven amyloidogenic determinants. Circular dichroism analysis and fluorescence spectroscopy with thioflavin T indicate the presence of β-sheet structures in Bgl2p isolates. Bgl2p forms fibrils, a process that is enforced in the presence of other cell wall components. Thus the data obtained is the first evidence for amyloid-like properties of yeast cell wall protein—glucantransferase Bgl2p. PMID:19098439

  14. 2. P.S. Rittermann, Photographer February 1995 BUILDING 990, WEST SIDE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. P.S. Rittermann, Photographer February 1995 BUILDING 990, WEST SIDE. - Presidio of San Francisco, Flammable Storage Building Submarine Mine Depot, Fort Point vicinity, Long Avenue, San Francisco, San Francisco County, CA

  15. Decay of Bogoliubov excitations in one-dimensional Bose gases

    NASA Astrophysics Data System (ADS)

    Ristivojevic, Zoran; Matveev, K. A.

    2016-07-01

    We study the decay of Bogoliubov quasiparticles in one-dimensional Bose gases. Starting from the hydrodynamic Hamiltonian, we develop a microscopic theory that enables one to systematically study both the excitations and their decay. At zero temperature, the leading mechanism of decay of a quasiparticle is disintegration into three others. We find that low-energy quasiparticles (phonons) decay with the rate that scales with the seventh power of momentum, whereas the rate of decay of the high-energy quasiparticles does not depend on momentum. In addition, our approach allows us to study analytically the quasiparticle decay in the whole crossover region between the two limiting cases. When applied to integrable models, including the Lieb-Liniger model of bosons with contact repulsion, our theory confirms the absence of the decay of quasiparticle excitations. We account for two types of integrability-breaking perturbations that enable finite decay: three-body interaction between the bosons and two-body interaction of finite range.

  16. Long-time behavior of many-particle quantum decay

    SciTech Connect

    Campo, A. del

    2011-07-15

    While exponential decay is ubiquitous in nature, deviations at both short and long times are dictated by quantum mechanics. Nonexponential decay is known to arise due to the possibility of reconstructing the initial state from the decaying products. We discuss the quantum decay dynamics by tunneling of a many-particle system, characterizing the long-time nonexponential behavior of the nonescape and survival probabilities. The effects of contact interactions and quantum statistics are described. It is found that, whereas for noninteracting bosons the long-time decay follows a power law with an exponent linear in the number of particles N, the exponent becomes quadratic in N in the fermionic case. The same results apply to strongly interacting many-body systems related by the generalized Bose-Fermi duality. The faster fermionic decay can be traced back to the effective hard-core interactions between particles, which are as well the decaying products, and exhibit spatial antibunching which hinders the reconstruction of the initial unstable state. The results are illustrated with a paradigmatic model of quantum decay from a trap allowing leaks by tunneling, whose dynamics is described exactly by means of an expansion in resonant states.

  17. Wood decay at sea

    NASA Astrophysics Data System (ADS)

    Charles, François; Coston-Guarini, Jennifer; Guarini, Jean-Marc; Fanfard, Sandrine

    2016-08-01

    The oceans and seas receive coarse woody debris since the Devonian, but the kinetics of wood degradation remains one of many unanswered questions about the fate of driftwood in the marine environment. A simple gravimetric experiment was carried out at a monitoring station located at the exit of a steep, forested Mediterranean watershed in the Eastern Pyrenees. The objective was to describe and quantify, with standardized logs (in shape, structure and constitution), natural degradation of wood in the sea. Results show that the mass decrease of wood logs over time can be described by a sigmoidal curve. The primary process of wood decay observed at the monitoring station was due to the arrival and installation of wood-boring species that consumed more than half of the total wood mass in six months. Surprisingly, in a region where there is little remaining wood marine infrastructure, "shipworms", i.e. xylophagous bivalves, are responsible for an important part of this wood decay. This suggests that these communities are maintained probably by a frequent supply of a large quantity of riparian wood entering the marine environment adjacent to the watershed. By exploring this direct link between terrestrial and marine ecosystems, our long term objective is to determine how these supplies of terrestrial organic carbon can sustain wood-based marine communities as it is observed in the Mediterranean Sea.

  18. Kinetics of the Reactions of Cl((sup 2)P(sub J)) and Br((sup 2)P(sub 3/2)) with O3

    NASA Technical Reports Server (NTRS)

    Nicovich, J. M.; Kreutter, K. D.; Wine, P. H.

    1997-01-01

    A laser flash photolysis-resonance fluorescence technique has been employed to study the kinetics of the important stratospheric reactions Cl((sup 2)P(sub J)) + O3 yields ClO + O2 and Br((sup 2)P(sub 3/2)) + O3 yields BrO + O2 as a function of temperature. The temperature dependence observed for the Cl((sup 2)P(sub J)) + O3 reaction is nonArrhenius, but can be adequately described by the following two Arrhenius expressions (units are cu cm/(molecule.s), errors are 2 sigma and represent precision only): k(sub 1)(T) = (1.19 +/- 0.21) x 10(exp -11) exp[(-33 +/- 37)/T] for T = 189-269 K and k(sub 1)(T) = (2.49 +/- 0.38) x 10(exp -11) exp[(-233 +/- 46)/T] for 269-385 K. At temperatures below 230 K, the rate coefficients determined in this study are faster than any reported previously. Incorporation of our values for k(sub 1)(T) into stratospheric models would increase calculated ClO levels and decrease calculated HCI levels; hence the calculated efficiency of ClO catalyzed ozone destruction would increase. The temperature dependence observed for the Br((sup 2)P(sub 3/2)) + O3 reaction is adequately described by the following Arrhenius expression (units are cu cm/(molecule.s), errors are 2 sigma and represent precision only): k(sub 2)(T) = (1.50 +/- 0.16) x 10(exp -11)exp[(-775 +/- 30)/T for 195-392 K. While not in quantitative agreement with Arrhenius parameters reported in most previous studies, our results almost exactly reproduce the average of all earlier studies and therefore will not affect the choice of k(sub 2)(T) for use in modeling stratospheric BrO2 chemistry.

  19. Inter-Coulombic decay (ICD) of endofullerene inner-vacancies in coherence with the Auger decay

    NASA Astrophysics Data System (ADS)

    Magrakvelidze, Maia; de, Ruma; Javani, Mohammad; Madjet, Mohamed; Manson, Steven T.; Chakraborty, Himadri

    2016-05-01

    For an endohedrally confined atom in a fullerene, an innershell vacancy created either in the atom or the fullerene can decay through the continuum of an outer electron hybridized between the systems. Such decays, which can be viewed as coherent superpositions of the single-center Auger and two-center inter-Coulombic (ICD) amplitudes, are found to govern leading decay mechanisms in endofullerenes. Resonances calculated by the method of time-dependent local density approximation (TDLDA) in the photoionization of noble gas endofullerenes show details of the underlying processes. These resonances are found to be significantly stronger than both regular ICD and Auger resonances, which make them well amenable for experimental detection. The work is supported by US NSF and DOE, Basic Energy Sciences.

  20. Measurement of the 2 sup 2 S sub 1/2 -2 sup 2 P sub 3/2 fine structure interval in muonium

    SciTech Connect

    Kettell, S.H.

    1990-08-01

    The (2{sup 2}S{sub 1/2} {minus} 2{sup 2}P{sub 3/2}) fine structure transition in muonium has been observed for the first time. The measured value is 9895 {sub {minus}30}{sup {plus}35}MHz. This measurement, when included with the theoretical value for the 2{sup 2}P{sub 1/2} {minus} 2{sup 2}P{sub 3/2} fine structure interval, gives a value for the Lamb shift (2{sup 2}S{sub 1/2} {minus} 2{sup 2}P{sub 1/2}) independent of previous direct measurements. From the theoretical value for the fine structure interval, 10921.833(3) MHz, the value for the Lamb shift determined from this experiment is 1027{sub {minus}35}{sup {plus}30} MHz and is in agreement with the prediction of quantum electrodynamics (QED) of 1047.5(3) MHz. Previous experimental values for the Lamb shift (2{sup 2}S{sub 1/2} {minus}2{sup 2}P{sub 1/2}) in muonium are 1070{sub {minus}15}{sup {plus} 12} MHz and 1042{sub {minus}23}{sup {plus}21} MHz. Combining this result with these previous results gives a new experimental value of 1058{sub {minus}12}{sup {plus}10} for the Lamb shift in muonium. Muonium, the bound state of two structureless leptons ({mu}{sup +}e{sup {minus}}), is an ideal system for testing bound state QED because of the lack of hadronic structure as exists in the hydrogen system. The measurement makes use of the techniques of atomic beam microwave spectroscopy. Muonium atoms ({mu}{sup +}e{sup {minus}}) in the 2S states are produced by the beam-foil technique at the Clinton P. Anderson Meson Physics Facility with a low momentum, sub-surface muon beam. A variable frequency microwave field is applied to drive the atoms from the 2S to the 2P states, with the subsequent observation of the Lyman alpha photon from the decay of the 2P state to the 1S ground state. The frequency is varied from 9.0--11.0 GHz, driving the F = 0 {yields} F = 1, F = 1, F = 1 and F = 1 {yields} F = 2 transitions.

  1. The impact of playout policy on the performance of P2P live streaming: or how not to kill your P2P advantage

    NASA Astrophysics Data System (ADS)

    Vassilakis, Constantinos; Laoutaris, Nikolaos; Stavrakakis, Ioannis

    2008-01-01

    In this paper we examine the impact of the adopted playout policy on the performance of P2P live streaming systems. We argue and demonstrate experimentally that (popular) playout policies which permit the divergence of the playout points of different nodes can deteriorate drastically the performance of P2P live streaming. Consequently, we argue in favor of keeping different playout points "near-in-time", even if this requires sacrificing (dropping) some late frames that could otherwise be rendered (assuming no strict bidirectional interactivity requirements are in place). Such nearly synchronized playout policies create "positive correlation" with respect to the available frames at different playout buffers. Therefore, they increase the number of upstream relay nodes from which a node can pull frames and thus boost the playout quality of both single-parent (tree) and multiple-parent (mesh) systems. On the contrary, diverging playout points reduce the number of upstream parents that can offer a gapless relay of the stream. This is clearly undesirable and should be avoided as it contradicts the fundamental philosophy of P2P systems which is to supplement an original service point with as many additional ones presented by the very own users of the service.

  2. Strategies for P2P connectivity in reconfigurable converged wired/wireless access networks.

    PubMed

    Puerto, Gustavo; Mora, José; Ortega, Beatriz; Capmany, José

    2010-12-01

    This paper presents different strategies to define the architecture of a Radio-Over-Fiber (RoF) Access networks enabling Peer-to-Peer (P2P) functionalities. The architectures fully exploit the flexibility of a wavelength router based on the feedback configuration of an Arrayed Waveguide Grating (AWG) and an optical switch to broadcast P2P services among diverse infrastructures featuring dynamic channel allocation and enabling an optical platform for 3G and beyond wireless backhaul requirements. The first architecture incorporates a tunable laser to generate a dedicated wavelength for P2P purposes and the second architecture takes advantage of reused wavelengths to enable the P2P connectivity among Optical Network Units (ONUs) or Base Stations (BS). While these two approaches allow the P2P connectivity in a one at a time basis (1:1), the third architecture enables the broadcasting of P2P sessions among different ONUs or BSs at the same time (1:M). Experimental assessment of the proposed architecture shows approximately 0.6% Error Vector Magnitude (EVM) degradation for wireless services and 1 dB penalty in average for 1 x 10(-12) Bit Error Rate (BER) for wired baseband services. PMID:21164969

  3. A study of a sector spectrophotometer and auroral O+(2P-2D) emissions

    NASA Technical Reports Server (NTRS)

    Swenson, G. R.

    1976-01-01

    The metastable O+(2P-2D) auroral emission was investigated. The neighboring OH contaminants and low intensity levels of the emission itself necessitated the evolution of an instrument capable of separating the emission from the contaminants and having a high sensitivity in the wavelength region of interest. A new type of scanning photometer was developed and its properties are discussed. The theoretical aspects of auroral electron interaction with atomic oxygen and the resultant O+(2P-2D) emissions were examined in conjunction with N2(+)1NEG emissions. Ground based measurements of O+(2P-2D) auroral emission intensities were made using the spatial scanning photometer (sector spectrophotometer). Simultaneous measurements of N2(+)1NEG sub 1,0 emission intensity were made in the same field of view using a tilting photometer. Time histories of the ratio of these two emissions made in the magnetic zenith during auroral breakup periods are given. Theories of I sub 7319/I sub 4278 of previous investigators were presented. A rocket measurement of N2(+)1NEG sub 0,0 and O+(2P-2D) emission in aurora was examined in detail and was found to agree with the ground based measurements. Theoretical examination resulted in the deduction of the electron impact efficiency generating O+(2P) and also suggests a large source of O+(2P) at low altitude. A possible source is charge exchange of N+(1S) with OI(3P).

  4. An A643T mutation in the transcription factor Upc2p causes constitutive ERG11 upregulation and increased fluconazole resistance in Candida albicans.

    PubMed

    Heilmann, Clemens J; Schneider, Sabrina; Barker, Katherine S; Rogers, P David; Morschhäuser, Joachim

    2010-01-01

    The zinc cluster transcription factor Upc2p mediates upregulation of ergosterol biosynthesis genes in response to ergosterol depletion in the fungal pathogen Candida albicans. One mechanism of acquired resistance to the antifungal drug fluconazole, which inhibits ergosterol biosynthesis, is constitutively increased expression of the ERG11 gene encoding the drug target enzyme. A G648D mutation in Upc2p has recently been shown to cause hyperactivity of the transcription factor, resulting in overexpression of ergosterol biosynthesis genes and increased fluconazole resistance. In order to investigate if gain-of-function mutations in Upc2p are a common mechanism of ERG11 upregulation and fluconazole resistance, we sequenced the UPC2 alleles of four ERG11-overexpressing, fluconazole-resistant C. albicans isolates and matched susceptible isolates from the same patients. In three of the isolate pairs, no differences in the UPC2 alleles were found, suggesting that mechanisms other than Upc2p mutations can cause ERG11 overexpression. One resistant isolate had become homozygous for a UPC2 allele containing a G1927A substitution that caused an alanine-to-threonine exchange at amino acid position 643 of Upc2p. Replacement of one of the endogenous UPC2 alleles in a fluconazole-susceptible strain by the UPC2(A643T) allele resulted in ERG11 overexpression and increased fluconazole resistance, which was further elevated when the A643T mutation was also introduced into the second UPC2 allele. These results further establish gain-of-function mutations in UPC2, which can be followed by loss of heterozygosity for the mutated allele, as a mechanism of ERG11 overexpression and increased fluconazole resistance in C. albicans, but other mechanisms of ERG11 upregulation also exist. PMID:19884367

  5. The 1.4-Å crystal structure of the S. pombe Pop2p deadenylase subunit unveils the configuration of an active enzyme

    PubMed Central

    Jonstrup, Anette Thyssen; Andersen, Kasper R.; Van, Lan B.; Brodersen, Ditlev E.

    2007-01-01

    Deadenylation is the first and probably also rate-limiting step of controlled mRNA decay in eukaryotes and therefore central for the overall rate of gene expression. In yeast, the process is maintained by the mega-Dalton Ccr4-Not complex, of which both the Ccr4p and Pop2p subunits are 3′–5′ exonucleases potentially responsible for the deadenylation reaction. Here, we present the crystal structure of the Pop2p subunit from Schizosaccharomyces pombe determined to 1.4 Å resolution and show that the enzyme is a competent ribonuclease with a tunable specificity towards poly-A. In contrast to S. cerevisiae Pop2p, the S. pombe enzyme contains a fully conserved DEDDh active site, and the high resolution allows for a detailed analysis of its configuration, including divalent metal ion binding. Functional data further indicates that the identity of the ions in the active site can modulate both activity and specificity of the enzyme, and finally structural superposition of single nucleotides and poly-A oligonucleotides provide insight into the catalytic cycle of the protein. PMID:17452359

  6. Resonant Edge Magnetoplasmons and Their Decay in Graphene

    NASA Astrophysics Data System (ADS)

    Kumada, N.; Roulleau, P.; Roche, B.; Hashisaka, M.; Hibino, H.; Petković, I.; Glattli, D. C.

    2014-12-01

    We investigate resonant edge magnetoplasmons (EMPs) and their decay in graphene by high-frequency electronic measurements. From EMP resonances in disk shaped graphene, we show that the dispersion relation of EMPs is nonlinear due to interactions, giving rise to the intrinsic decay of EMP wave packets. We also identify extrinsic dissipation mechanisms due to interaction with localized states in bulk graphene from the decay time of EMP wave packets. We indicate that, owing to the linear band structure and the sharp edge potential, EMP dissipation in graphene can be lower than that in GaAs systems.

  7. Alpha decay in electron surrounding

    SciTech Connect

    Igashov, S. Yu.; Tchuvil’sky, Yu. M.

    2013-12-15

    The influence of atomic electron shells on the constant of alpha decay of heavy and mediummass nuclei was considered in detail. A method for simultaneously taking into account the change in the potential-barrier shape and the effect of reflection of a diverging Coulomb wave in the classically allowed region was developed. The ratios of decay probabilities per unit time for a bare nucleus and the respective neutral atom were found for some alpha-decaying isotopes.

  8. Search for rare B decays

    NASA Astrophysics Data System (ADS)

    Albrecht, H.; Hamacher, T.; Hofmann, R. P.; Kirchhoff, T.; Mankel, R.; Nau, A.; Nowak, S.; Reßing, D.; Schröder, H.; Schulz, H. D.; Walter, M.; Wurth, R.; Hast, C.; Kapitza, H.; Kolanoski, H.; Kosche, A.; Lange, A.; Lindner, A.; Schieber, M.; Siegmund, T.; Spaan, B.; Thurn, H.; Töpfer, D.; Wegener, D.; Eckstein, P.; Frankl, C.; Graf, J.; Schmidtler, M.; Schramm, M.; Schubert, K. R.; Schwierz, R.; Waldi, R.; Reim, K.; Wegener, H.; Eckmann, R.; Kuipers, H.; Mai, O.; Mundt, R.; Oest, T.; Reiner, R.; Schmidt-Parzefall, W.; Stiewe, J.; Werner, S.; Ehret, K.; Hofmann, W.; Hüpper, A.; Knöpfle, K. T.; Spengler, J.; Krieger, P.; Macfarlane, D. B.; Prentice, J. D.; Saull, P. R. B.; Tzamariudaki, K.; van de Water, R. G.; Yoon, T.-S.; Schneider, M.; Weseler, S.; Kernel, G.; Križan, P.; Križnič, E.; Podobnik, T.; Živko, T.; Balagura, V.; Barsuk, S.; Belyaev, I.; Chistov, R.; Danilov, M.; Gershtein, L.; Gershtein, Yu.; Golutyin, A.; Korolko, I.; Kostina, G.; Litvintsev, D.; Pakhlov, P.; Semenov, S.; Snizhko, A.; Tichomirov, I.; Zaitsev, Yu.; Argus Collaboration

    1995-02-01

    Using the ARGUS detector at the e +e - storage ring DORIS II at DESY, we have searched for decays b → sgluon through full reconstruction of a whole event. Two B overlineB decays were found with one of B meson decaying into a final state without charmed particles. We also obtained an upper limit of Br(B + → τ+ντ) of 1.04% at 90% CL.

  9. Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer.

    PubMed

    Inoue, Kazushi; Fry, Elizabeth A

    2016-07-01

    Alternative splicing (AS) of mRNA precursors is a ubiquitous mechanism for generating numerous transcripts with different activities from one genomic locus in mammalian cells. The gene products from a single locus can thus have similar, dominant-negative or even opposing functions. Aberrant AS has been found in cancer to express proteins that promote cell growth, local invasion and metastasis. This review will focus on the aberrant splicing of tumor suppressor/oncogenes that belong to the DMP1-ARF-MDM2-p53 pathway. Our recent study shows that the DMP1 locus generates both tumor-suppressive DMP1α (p53-dependent) and oncogenic DMP1β (p53-independent) splice variants, and the DMP1β/α ratio increases with neoplastic transformation of breast epithelial cells. This process is associated with high DMP1β protein expression and shorter survival of breast cancer (BC) patients. Accumulating pieces of evidence show that ARF is frequently inactivated by aberrant splicing in human cancers, demonstrating its involvement in human malignancies. Splice variants from the MDM2 locus promote cell growth in culture and accelerate tumorigenesis in vivo. Human cancers expressing these splice variants are associated with advanced stage/metastasis, and thus have negative clinical impacts. Although they lack most of the p53-binding domain, their activities are mostly dependent on p53 since they bind to wild-type MDM2. The p53 locus produces splice isoforms that have either favorable (β/γ at the C-terminus) or negative impact (Δ40, Δ133 at the N-terminus) on patients' survival. As the oncogenic AS products from these loci are expressed only in cancer cells, they may eventually become targets for molecular therapies. PMID:26802432

  10. Chromosome 2p shows significant linkage to antihypertensive response in the British Genetics of Hypertension Study.

    PubMed

    Padmanabhan, Sandosh; Wallace, Chris; Munroe, Patricia B; Dobson, Richard; Brown, Morris; Samani, Nilesh; Clayton, David; Farrall, Martin; Webster, John; Lathrop, Mark; Caulfield, Mark; Dominiczak, Anna F; Connell, John M

    2006-03-01

    There is a lack of consistently linked loci influencing blood pressure and hypertension status, and this may be because of genetic or phenotypic heterogeneity. We hypothesize that stratification of subjects by response to antihypertensive drug groups could be used to stringently define subsets that will have reduced genetic and etiologic heterogeneity, by partitioning contrasting mechanisms of hypertension and, thus, enhancing gene finding. We investigated the British Genetics of Hypertension Study population, which is composed of 2142 severely hypertensive white affected sibling pairs. Nonresponse to antihypertensive therapy was defined as an on-treatment blood pressure of >140/90 mm Hg or a difference between prediagnosis and on-treatment blood pressure of <20 mm Hg. Of the nonresponders, there were 89 sibling pairs (AB) who were both on antihypertensive therapy that inhibit the renin-angiotensin system (angiotensin-converting enzyme inhibitors, angiotensin II type-1 receptor blockers, or beta-blockers), and 76 sibling pairs (CD) who were both on drugs that do not (calcium channel blockers or diuretics). Nonparametric linkage analysis carried out using markers from a 10-cM genome scan and additional "grid tightening" markers showed significant linkage in the AB group on chromosome 2p (logarithm of odds=4.84 at 90.68 Kosambi cM) and suggestive linkage for the CD group on chromosome 10q (logarithm of odds=2.83 at 125.96 Kosambi cM). The AB linkage locus attained genomewide significance after simulation using 10,000 replicates (P=0.005). This locus may contain a gene for the salt-sensitive form of hypertension and/or a pharmacogenetic locus affecting drug response. We have demonstrated for the first time identification of a significant locus by partitioning different pathways of hypertension using drug response. PMID:16391175

  11. 2P/Encke, the Taurid complex NEOs and the Maribo and Sutter's Mill meteorites

    NASA Astrophysics Data System (ADS)

    Tubiana, C.; Snodgrass, C.; Michelsen, R.; Haack, H.; Böhnhardt, H.; Fitzsimmons, A.; Williams, I. P.

    2015-12-01

    Aims: 2P/Encke is a short period comet that was discovered in 1786 and has been extensively observed and studied for more than 200 years. The Taurid meteoroid stream has long been linked with 2P/Encke owing to a good match of their orbital elements, even though the comet's activity is not strong enough to explain the number of observed meteors. Various small near-Earth objects (NEOs) have been discovered with orbits that can be linked to 2P/Encke and the Taurid meteoroid stream. Maribo and Sutter's Mill are CM type carbonaceous chondrite that fell in Denmark on January 17, 2009 and April 22, 2012, respectively. Their pre-atmospheric orbits place them in the middle of the Taurid meteoroid stream, which raises the intriguing possibility that comet 2P/Encke could be the parent body of CM chondrites. Methods: To investigate whether a relationship between comet 2P/Encke, the Taurid complex associated NEOs, and CM chondrites exists, we performed photometric and spectroscopic studies of these objects in the visible wavelength range. We observed 2P/Encke and 10 NEOs on August 2, 2011 with the FORS instrument at the 8.2 m Very Large Telescope on Cerro Paranal (Chile). Results: Images in the R filter, used to investigate the possible presence of cometary activity around the nucleus of 2P/Encke and the NEOs, show that no resolved coma is present. None of the FORS spectra show the 700 nm absorption feature due to hydrated minerals that is seen in the CM chondrite meteorites. All objects show featureless spectra with moderate reddening slopes at λ< 800 nm. Apart for 2003 QC10 and 1999 VT25, which show a flatter spectrum, the spectral slope of the observed NEOs is compatible with that of 2P/Encke. However, most of the NEOs show evidence of a silicate absorption in lower S/N data at λ> 800 nm, which is not seen in 2P/Encke, which suggests that they are not related. Conclusions: Despite similar orbits, we find no spectroscopic evidence for a link between 2P/Encke, the Taurid

  12. CP violation in K decays and rare decays

    SciTech Connect

    Buchalla, G.

    1996-12-01

    The present status of CP violation in decays of neutral kaons is reviewed. In addition selected rare decays of both K and B mesons are discussed. The emphasis is in particular on observables that can be reliably calculated and thus offer the possibility of clean tests of standard model flavor physics. 105 refs.

  13. Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic cancer by derepressing the miR-3923/KRAS pathway.

    PubMed

    Li, Xiang; Deng, Shi-jiang; Zhu, Shuai; Jin, Yan; Cui, Shi-peng; Chen, Jing-yuan; Xiang, Cheng; Li, Qun-ying; He, Chi; Zhao, Shu-feng; Chen, Heng-yu; Niu, Yi; Liu, Yang; Deng, Shi-chang; Wang, Chun-you; Zhao, Gang

    2016-02-01

    Recent studies indicate that long non-coding RNAs (lncRNAs) play crucial roles in numerous cancers, while their function in pancreatic cancer is rarely elucidated. The present study identifies a functional lncRNA and its potential role in tumorigenesis of pancreatic cancer. Microarray co-assay for lncRNAs and mRNAs demonstrates that lncRNA-NUTF2P3-001 is remarkably overexpressed in pancreatic cancer and chronic pancreatitis tissues, which positively correlates with KRAS mRNA expression. After downregulating lncRNA-NUTF2P3-001, the proliferation and invasion of pancreatic cancer cell are significantly inhibited both in vitro and vivo, accompanying with decreased KRAS expression. The dual-luciferase reporter assay further validates that lncRNA-NUTF2P3-001 and 3'UTR of KRAS mRNA competitively bind with miR-3923. Furthermore, miR-3923 overexpression simulates the inhibiting effects of lncRNA-NUTF2P3-001-siRNA on pancreatic cancer cell, which is rescued by miR-3923 inhibitor. Specifically, the present study further reveals that lncRNA-NUTF2P3-001 is upregulated in pancreatic cancer cells under hypoxia and CoCl2 treatment, which is attributed to the binding of hypoxia-inducible factor-1α (HIF-1α) to hypoxia response elements (HREs) in the upstream of KRAS promoter. Data from pancreatic cancer patients show a positive correlation between lncRNA-NUTF2P3-001 and KRAS, which is associated with advanced tumor stage and worse prognosis. Hence, our data provide a new lncRNA-mediated regulatory mechanism for the tumor oncogene KRAS and implicate that lncRNA-NUTF2P3-001 and miR-3923 can be applied as novel predictors and therapeutic targets for pancreatic cancer. PMID:26755660

  14. Photoexcitation and photoionization from the 2p53p[5/2]2,3 levels in neon

    NASA Astrophysics Data System (ADS)

    Baig, M. A.; Bokhari, I. A.; Rafiq, M.; Kalyar, M. A.; Hussian, T.; Ali, Raheel; Piracha, N. K.

    2011-07-01

    We present measurements of the excitation spectra from the 2p53p [5/2]3,2 levels in neon using two-step laser excitation and ionization in conjunction with an optogalvanic detection in dc and rf discharge cells. The 2p53p [5/2]3,2 intermediate levels have been approached via the collisionally populated 2p53s [3/2]2 metastable level. The Rydberg series 2p5(2P3/2)nd [7/2]4 (12 ⩽ n ⩽ 44), 2p5(2P3/2)ns [3/2]2 (13 ⩽ n ⩽ 35) and the parity forbidden transitions 2p5(2P3/2)np [5/2]3 (13 ⩽ n ⩽ 19) have been observed from the 2p53p [5/2]3 level, whereas the 2p5(2P3/2)nd [7/2]3 (12 ⩽ n ⩽ 44), 2p5(2P3/2)ns [3/2]2 (13 ⩽ n ⩽ 35), and 2p5(2P1/2)nd' [5/2]3 (9 ⩽ n ⩽ 12) Rydberg series have been observed from the 2p53p[5/2]2 level in accordance with the ΔJ = ΔK = ± 1 selection rules. The photoionization cross sections from the 2p53p [5/2]3 intermediate level have been measured at eight ionizing laser wavelengths (399, 395, 390, 385, 380, 370, 364, and 355 nm) and that from the 2p53p [5/2]2 level at 401.8 nm. These measurements are in excellent agreement with the experimental values reported in the literature, while the experimental data lie much below the theoretically calculated photoionization cross sections curve.

  15. EuCo2P2 : A model molecular-field helical Heisenberg antiferromagnet

    NASA Astrophysics Data System (ADS)

    Sangeetha, N. S.; Cuervo-Reyes, Eduardo; Pandey, Abhishek; Johnston, D. C.

    2016-07-01

    The metallic compound EuCo2P2 with the body-centered tetragonal ThCr2Si2 structure containing Eu spins-7/2 was previously shown from single-crystal neutron diffraction measurements to exhibit a helical antiferromagnetic (AFM) structure below TN=66.5 K with the helix axis along the c axis and with the ordered moments aligned within the a b plane. Here we report crystallography, electrical resistivity, heat capacity, magnetization, and magnetic susceptibility measurements on single crystals of this compound. We demonstrate that EuCo2P2 is a model molecular-field helical Heisenberg antiferromagnet from comparisons of the anisotropic magnetic susceptibility χ , high-field magnetization, and magnetic heat capacity of EuCo2P2 single crystals at temperature T ≤TN with the predictions of our recent formulation of molecular-field theory. Values of the Heisenberg exchange interactions between the Eu spins are derived from the data. The low-T magnetic heat capacity ˜T3 arising from spin-wave excitations with no anisotropy gap is calculated and found to be comparable to the lattice heat capacity. The density of states at the Fermi energy of EuCo2P2 and the related compound BaCo2P2 are found from the heat capacity data to be large, 10 and 16 states/eV per formula unit for EuCo2P2 and BaCo2P2 , respectively. These values are enhanced by a factor of ˜2.5 above those found from DFT electronic structure calculations for the two compounds. The calculations also find ferromagnetic Eu-Eu exchange interactions within the a b plane and AFM interactions between Eu spins in nearest- and next-nearest planes, in agreement with the MFT analysis of χa b(T ≤TN) .

  16. EuCo2P2: A model molecular-field helical Heisenberg antiferromagnet

    DOE PAGESBeta

    Sangeetha, N. S.; Cuervo-Reyes, Eduardo; Pandey, Abhishek; Johnston, D. C.

    2016-07-19

    Here, the metallic compound EuCo2P2 with the body-centered tetragonal ThCr2Si2 structure containing Eu spins-7/2 was previously shown from single-crystal neutron diffraction measurements to exhibit a helical antiferromagnetic (AFM) structure below TN=66.5 K with the helix axis along the c axis and with the ordered moments aligned within the ab plane. Here we report crystallography, electrical resistivity, heat capacity, magnetization, and magnetic susceptibility measurements on single crystals of this compound. We demonstrate that EuCo2P2 is a model molecular-field helical Heisenberg antiferromagnet from comparisons of the anisotropic magnetic susceptibility χ, high-field magnetization, and magnetic heat capacity of EuCo2P2 single crystals at temperaturemore » T ≤ TN with the predictions of our recent formulation of molecular-field theory. Values of the Heisenberg exchange interactions between the Eu spins are derived from the data. The low-T magnetic heat capacity ~T3 arising from spin-wave excitations with no anisotropy gap is calculated and found to be comparable to the lattice heat capacity. The density of states at the Fermi energy of EuCo2P2 and the related compound BaCo2P2 are found from the heat capacity data to be large, 10 and 16 states/eV per formula unit for EuCo2P2 and BaCo2P2, respectively. These values are enhanced by a factor of ~2.5 above those found from DFT electronic structure calculations for the two compounds. The calculations also find ferromagnetic Eu–Eu exchange interactions within the ab plane and AFM interactions between Eu spins in nearest- and next-nearest planes, in agreement with the MFT analysis of χab(T ≤ TN).« less

  17. Theoretical Stark widths and shifts of spectral lines of 2p5nf and 2p55g configurations of Mg III

    NASA Astrophysics Data System (ADS)

    Moreno-Díaz, Cristina; Alonso-Medina, Aurelia; Colón, Cristóbal

    2014-11-01

    In this paper, we report theoretical Stark widths and shifts calculated using the Griem semi-empirical approach, which corresponds to 111 spectral lines of Mg III. The values of these Stark broadening parameters of spectral lines that arise from levels of 2p5nf and 2p55g configurations of Mg III are presented in the literature for the first time. The aim of this work is to provide values to estimate the electron density of plasma Mg III in astrophysics and industrial applications. The data are presented for the temperatures T = 0.5-10.0 (104 K) and for an electron density of 1017 cm-3. The matrix of elements used in these calculations has been determined from 23 configurations of Mg III: 2s22p6, 2s22p53p, 2s22p54p, 2s22p54f and 2s22p55f for the even parity and 2s22p5ns (n = 3-6), 2s22p5nd (n = 3-9), 2s22p55g and 2s2p6np (n = 3-8) for the odd parity. For the intermediate coupling calculations, we use the standard method of least square fitting from experimental energy levels by means of Cowan’s computer code. Lines with wavelengths of 134.6460, 135.2800, 189.0380, 190.0043, 192.8424, 408.2939 and 409.4375 nm have high probabilities and also have high values of broadening. Therefore, these lines can be used in some applications. A common regularity for the Stark width of the 189.038 nm spectral line of Mg III is discussed.

  18. The Role of Vibrational Excitation on the Dynamics of the F(^2P) + HCl → FH + Cl(2P) Hydrogen-Transfer Reaction

    NASA Astrophysics Data System (ADS)

    Ray, Sara E.; Vissers, G. W. M.; McCoy, Anne B.

    2010-06-01

    Recently, open-shell systems have gained interest in experimental and theoretical science. What proves interesting about these open-shell systems is that the potential energy surfaces often contain a van der Waals well in the reactant or product channel that allows researchers to probe the pre-reactive species. Here we present the results of time-dependent quantum wave packet calculations on the asymmetric hydrogen-transfer reaction of F(^SUP>2P) + HCl. In these calculations, the reaction is initiated by vibrationally exciting the HCl stretching motion of the pre-reactive F\\cdotsHCl complex in the van der Waals well. The wave packet is propagated on a three-dimensional, fully coupled potential energy surface that has been constructed based on electronic energies calculated at the multi-reference configuration interation+Davidson correction (MRCI+Q) level of theory with an aug-cc-pVnZ (n=2,3,4) basis. Product state distributions were calculated for reactions initiated in the first three vibrationally excited states of HCl, v=1, 2, and 3. Specifically, we analyzed the final electronic, vibrational, and rotational distributions. Previous studies on the hydrogen-transfer reaction of the Cl(^2P) + HCl system focused on whether vibrational excitation of the HCl stretch would promote the reaction and if so, how the reaction dynamics reflect the coupling among the diabatic potential surfaces that describe this system. We also compare our F(^2P) + HCl results to those of this related system. M. P. Deskevich, M. Y. Hayes, K. Takahashi, R. T. Skodje, and D. J. Nesbitt J. Chem. Phys., 124(22) 224303 (2006) G. W. M. Vissers and A. B. McCoy J. Phys Chem. A, 110 5978 (2006)

  19. A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice.

    PubMed

    Shoji, Haruka; Kiniwa, Yukiko; Okuyama, Ryuhei; Yang, Mu; Higuchi, Keiichi; Mori, Masayuki

    2015-01-01

    The original pink-eyed dilution (p) on chromosome 7 is a very old spontaneous mutation in mice. The oculocutaneous albinism II (Oca2) gene has previously been identified as the p gene. Oca2 transcripts have been shown to be absent in the skin of SJL/J mice with the original p mutant allele (Oca2(p)); however, the molecular genetic lesion underlying the original Oca2(p) allele has never been reported. The NCT mouse (commonly known as Nakano cataract mouse) has a pink-eyed dilution phenotype, which prompted us to undertake a molecular genetic analysis of the Oca2 gene of this strain. Our genetic linkage analysis suggests that the locus for the pink-eyed dilution phenotype of NCT is tightly linked to the Oca2 locus. PCR cloning and nucleotide sequence analysis indicates that the NCT mouse has a nonsense nucleotide substitution at exon 7 of the Oca2 gene. Examination of three mouse strains (NZW/NSlc, SJL/J, and 129X1/SvJJmsSlc) with the original Oca2(p) allele revealed the presence of a nonsense nucleotide substitution identical to that in the NCT strain. RT-PCR analysis revealed that the Oca2 transcripts were absent in the skin of NCT mice, suggesting intervention of the nonsense-mediated mRNA decay pathway. Collectively, the data in this study indicate that the nonsense nucleotide substitution in the Oca2 gene underlies the Oca2(p) allele. Our data also indicate that the NCT mouse can be used not only as a cataract model, but also as a model for human type II oculocutaneous albinism. PMID:25736709

  20. Tau decays: A theoretical perspective

    SciTech Connect

    Marciano, W.J.

    1992-11-01

    Theoretical predictions for various tau decay rates are reviewed. Effects of electroweak radiative corrections are described. Implications for precision tests of the standard model and ``new physics`` searches are discussed. A perspective on the tau decay puzzle and 1-prong problem is given.

  1. Tau decays: A theoretical perspective

    SciTech Connect

    Marciano, W.J.

    1992-11-01

    Theoretical predictions for various tau decay rates are reviewed. Effects of electroweak radiative corrections are described. Implications for precision tests of the standard model and new physics'' searches are discussed. A perspective on the tau decay puzzle and 1-prong problem is given.

  2. Theoretical understanding of charm decays

    SciTech Connect

    Bigi, I.I.

    1986-08-01

    A detailed description of charm decays has emerged. The various concepts involved are sketched. Although this description is quite successful in reproducing the data the chapter on heavy flavour decays is far from closed. Relevant questions like on th real strength of weak annihilation, Penguin operators, etc. are still unanswered. Important directions in future work, both on the experimental and theoretical side are identified.

  3. Raman spectroscopic study of (Ph 2P) 2CCH 2 and [(Ph 2P) 2CCH 2]W(CO) 4

    NASA Astrophysics Data System (ADS)

    Fickert, C.; Posset, U.; Kiefer, W.

    1997-06-01

    The Raman and IR spectra of 1,1-bis[diphenylphosphino]ethene (Ph 2P) 2CCH 2 (vdpp) and the tetracarbonyl tungsten complex (vdpp)W(CO) 4 have been recorded. Vibrational assignments are proposed based on local symmetry considerations. For the vinylidene stretching mode a coordination shift is observed from 1588 cm -1 in polycrystalline vdpp to 1581 cm -1 in its tetracarbonyl tungsten complex. From a comparison of the v(CO) splitting pattern with those of related complexes monoclinic structure with factor group C2h and four formula units per unit cell is concluded.

  4. pH-Sensitive K(+) Currents and Properties of K2P Channels in Murine Hippocampal Astrocytes.

    PubMed

    Weller, Johannes; Steinhäuser, Christian; Seifert, Gerald

    2016-01-01

    Based on their intimate spatial association with synapses and the capillary, astrocytes are critically involved in the control of ion, transmitter, and energy homeostasis as well as regulation of the cerebral blood flow. Under pathophysiological conditions, dysfunctional astrocytes can no longer assure homeostatic control although the underlying mechanisms are poorly understood. Specifically, neurological diseases are often accompanied by acidification of the extracellular space, but the properties of astrocytes in such an acidic environment are still a matter of debate. To meet the homeostatic requirements, astrocytes are equipped with intercellular gap junctions, inwardly rectifying K(+) (Kir) channels, and two-pore domain K(+) (K2P) channels. One goal of the present study was to overview current knowledge about astrocyte K(+) channel function during acidosis. In addition, we combined functional and molecular analyses to clarify how low pH affects K(+) channel function in astrocytes freshly isolated from the developing mouse hippocampus. Extracellular acidification led to a decrease of K(+) currents in astrocytes, probably due to modulation of Kir4.1 channels. After blocking Kir4.1 channels, low pH enhanced K(+) current amplitudes. This current activation was mimicked by modulators of TREK-1 channels, which belong to the K2P channels family. We found no evidence for the presence of acid-sensitive ion channels and transient receptor potential vanilloid receptors in hippocampal astrocytes. In conclusion, the assembly of astrocytic K(+) channels allows tolerating short, transient acidification, and glial Kir4.1 and K2P channels can be considered promising new targets in brain diseases accompanied by pH shifts. PMID:26920692

  5. Sbe2p and Sbe22p, Two Homologous Golgi Proteins Involved in Yeast Cell Wall Formation

    PubMed Central

    Santos, Beatriz; Snyder, Michael

    2000-01-01

    The cell wall of fungal cells is important for cell integrity and cell morphogenesis and protects against harmful environmental conditions. The yeast cell wall is a complex structure consisting mainly of mannoproteins, glucan, and chitin. The molecular mechanisms by which the cell wall components are synthesized and transported to the cell surface are poorly understood. We have identified and characterized two homologous yeast proteins, Sbe2p and Sbe22p, through their suppression of a chs5 spa2 mutant strain defective in chitin synthesis and cell morphogenesis. Although sbe2 and sbe22 null mutants are viable, sbe2 sbe22 cells display several phenotypes indicative of defects in cell integrity and cell wall structure. First, sbe2 sbe22 cells display a sorbitol-remediable lysis defect at 37°C and are hypersensitive to SDS and calcofluor. Second, electron microscopic analysis reveals that sbe2 sbe22 cells have an aberrant cell wall structure with a reduced mannoprotein layer. Finally, immunofluorescence experiments reveal that in small-budded cells, sbe2 sbe22 mutants mislocalize Chs3p, a protein involved in chitin synthesis. In addition, sbe2 sbe22 diploids have a bud-site selection defect, displaying a random budding pattern. A Sbe2p–GFP fusion protein localizes to cytoplasmic patches, and Sbe2p cofractionates with Golgi proteins. Deletion of CHS5, which encodes a Golgi protein involved in the transport of Chs3p to the cell periphery, is lethal in combination with disruption of SBE2 and SBE22. Thus, we suggest a model in which Sbe2p and Sbe22p are involved in the transport of cell wall components from the Golgi apparatus to the cell surface periphery in a pathway independent of Chs5p. PMID:10679005

  6. Prognostic value of replication errors on chromosomes 2p and 3p in non-small-cell lung cancer.

    PubMed Central

    Pifarré, A.; Rosell, R.; Monzó, M.; De Anta, J. M.; Moreno, I.; Sánchez, J. J.; Ariza, A.; Mate, J. L.; Martińez, E.; Sánchez, M.

    1997-01-01

    As chromosomes 2p and 3p are frequent targets for genomic instability in lung cancer, we have addressed whether alterations of simple (CA)n DNA repeats occur in non-small-cell lung cancer (NSCLC) at early stages. We have analysed by polymerase chain reaction (PCR) assay replication errors (RER) and loss of heterozygosity (LOH) at microsatellites mapped on chromosomes 2p and 3p in 64 paired tumour-normal DNA samples from consecutively resected stage I, II or IIIA NSCLC. DNA samples were also examined for K-ras and p53 gene mutations by PCR-single-stranded conformational polymorphism (PCR-SSCP) analysis and cyclic sequencing, as well as their relationship with clinical outcome. Forty-two of the 64 (66%) NSCLC patients showed RER at single or multiple loci. LOH was detected in 23 tumours (36%). Among patients with stage I disease, the 5-year survival rate was 80% in those whose tumours had no evidence of RER and 26% in those with RER (P = 0.005). No correlation was established between RER phenotype and LOH, K-ras or p53 mutations. RER remained a strong predictive factor (hazard ratio for death, 2.89; 95% confidence interval, 2.23-3.79; P = 0.002) after adjustment for all other evaluated factors, including p53, K-ras, LOH, histological type, tumour differentiation and TNM stage, suggesting that microsatellite instability on chromosomes 2p and 3p may play a role in NSCLC progression through a different pathway from the traditional tumour mechanisms of oncogene activation and/or tumour-suppressor gene inactivation. Images Figure 1 PMID:9010024

  7. A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription.

    PubMed

    Onel, Buket; Carver, Megan; Wu, Guanhui; Timonina, Daria; Kalarn, Salil; Larriva, Marti; Yang, Danzhou

    2016-03-01

    The abnormal overexpression of the BCL2 gene is associated with many human tumors. We found a new 28-mer G-quadruplex-forming sequence, P1G4, immediately upstream of the human BCL2 gene P1 promoter. The P1G4 is shown to be a transcription repressor using a promoter-driven luciferase assay; its inhibitory effect can be markedly enhanced by the G-quadruplex-interactive compound TMPyP4. G-quadruplex can readily form in the P1G4 sequence under physiological salt condition as shown by DMS footprinting. P1G4 and previously identified Pu39 G-quadruplexes appear to form independently in adjacent regions in the BCL2 P1 promoter. In the extended BCL2 P1 promoter region containing both Pu39 and P1G4, P1G4 appears to play a more dominant role in repressing the transcriptional activity. Using NMR spectroscopy, the P1G4 G-quadruplex appears to be a novel dynamic equilibrium of two parallel structures, one regular with two 1-nt loops and a 12-nt middle loop and another broken-strand with three 1-nt loops and a 11-nt middle loop; both structures adopt a novel hairpin (stem-loop duplex) conformation in the long loop. The dynamic equilibrium of two closely related structures and the unique hairpin loop conformation are specific to the P1G4 sequence and distinguish the P1G4 quadruplex from other parallel structures. The presence of P1G4 and Pu39 in adjacent regions of the BCL2 P1 promoter suggests a mechanism for precise regulation of BCL2 gene transcription. The unique P1G4 G-quadruplex may provide a specific target for small molecules to modulate BCL2 gene transcription. PMID:26841249

  8. Phase-space exploration in nuclear giant resonance decay

    SciTech Connect

    Drozdz, S.; Nishizaki, S.; Wambach, J.; Speth, J. Institute of Nuclear Physics, PL-31-342 Krakow Department of Physics, University of Illinois at Urbana, Illinois 61801 College of Humanities and Social Sciences, Iwate University, Ueda 3-18-34, Morioka 020 )

    1995-02-13

    The rate of phase-space exploration in the decay of isovector and isoscalar giant quadrupole resonances in [sup 40]Ca is analyzed. The study is based on the time dependence of the survival probability and of the spectrum of generalized entropies evaluated in the space of one-particle--one-hole (1p-1h) and 2p-2h states. Three different cases for the level distribution of 2p-2h background states, corresponding to (a) high degeneracy, (b) classically regular motion, and (c) classically chaotic motion, are studied. In the latter case the isovector excitation evolves almost statistically while the isoscalar excitation remains largely localized, even though it penetrates the whole available phase space.

  9. Complex Configuration Effects on β-DECAY Rates

    NASA Astrophysics Data System (ADS)

    Severyukhin, A. P.; Voronov, V. V.; Borzov, I. N.; Arsenyev, N. N.; van Giai, Nguyen

    2015-06-01

    Starting from a Skyrme interaction the Gamow-Teller (GT) strength in the Qβ- window has been studied within a microscopic model including the 2p-2h configuration effects. The suggested approach enables one to perform the calculations in very large configuration spaces. As a result, the β--decay halflife is decreased due to the 2p - 2h fragmentation of GT states. Using the Skyrme interaction SGII with tensor terms we study this reduction effect for the neutron-rich N = 82 isotones below the doubly magic nucleus 132Sn. Predictions are given for 126Ru and 128Pd in comparison to 130Cd which is the r-process waiting-point nucleus.

  10. Top decays in extended models

    SciTech Connect

    Gaitan, R.; Miranda, O. G.; Cabral-Rosetti, L. G.

    2009-04-20

    Top quark decays are interesting as a mean to test the Standard Model (SM) predictions. The Cabbibo-Kobayashi-Maskawa (CKM)-suppressed process t{yields}cWW, and the rare decays t{yields}cZ, t{yields}H{sup 0}+c, and t{yields}c{gamma} an excellent window to probe the predictions of theories beyond the SM. We evaluate the flavor changing neutral currents (FCNC) decay t{yields}H{sup 0}+c in the context of Alternative Left-Right symmetric Models (ALRM) with extra isosinglet heavy fermions; the FCNC decays may place at tree level and are only supressed by the mixing between ordinary top and charm quarks. We also comment on the decay process t{yields}c+{gamma}, which involves radiative corrections.

  11. Logarithmic decays of unstable states

    NASA Astrophysics Data System (ADS)

    Giraldi, Filippo

    2015-01-01

    It is known that the survival amplitude of unstable quantum states deviates from exponential relaxations and exhibits decays that depend on the integral and analytic properties of the energy distribution density. In the same scenario, model independent dominant logarithmic decays t -1- α0log t of the survival amplitude are induced over long times by special conditions on the energy distribution density. While the instantaneous decay rate exhibits the dominant long time relaxation 1 / t, the instantaneous energy tends to the minimum value of the energy spectrum with the dominant logarithmic decay 1/( tlog 2 t) over long times. Similar logarithmic relaxations have already been found in the dynamics of short range potential systems with even dimensional space or in the Weisskopf-Wigner model of spontaneous emission from a two-level atom. Here, logarithmic decays are obtained as a pure model independent quantum effect in general unstable states.

  12. Discovery of a nonyrast K{sup {pi}}=8{sup +} isomer in {sup 162}Dy, and the influence of competing K-mixing mechanisms on its highly forbidden decay

    SciTech Connect

    Swan, T. P. D.; Walker, P. M.; Podolyak, Zs.; Reed, M. W.; Dracoulis, G. D.; Lane, G. J.; Kibed, T.; Smith, M. L.

    2011-03-15

    The {sup 160}Gd({sup 9}Be,{alpha}3n){sup 162}Dy reaction has been used to study high-spin states in {sup 162}Dy. Pulsed beam conditions were utilized for enhanced isomer sensitivity. An isomer at 2188.1(3) keV with a half-life of 8.3(3) {mu}s has been discovered and assigned K{sup {pi}}= 8{sup +} with a two-quasineutron configuration. Among 11 {gamma}-ray decay branches, an E2, {Delta}K=8 transition to the ground-state band was observed with a reduced hindrance of f{sub {nu}}=35, agreeing well with systematics correlating f{sub {nu}} with the product of the valence neutron and proton numbers (N{sub p}N{sub n}) over an extended N,Z range. Small deviations from N{sub p}N{sub n} dependence are analyzed for a range of two-quasiparticle isomer decays and interpreted as arising from a weak dependence on the isomer excitation energy relative to the yrast line.

  13. A resources monitoring architecture for P2P file-sharing systems

    NASA Astrophysics Data System (ADS)

    Wang, Wenxian; Chen, Xingshu; Wang, Haizhou

    2013-07-01

    Resources monitoring is an important problem of the overall efficient usage and control of P2P file-sharing systems. The resources of file-sharing systems can include all distributing servers, programs and peers. Several researches have tried to address this issue, but most of them illuminated P2P traffic characterization, identification and user behavior. Based on previous work, we present a resources monitoring architecture for P2P file-sharing systems. The monitoring architecture employs a hierarchical structure and provides systemic monitoring including resources discovery, relative information extraction and analysis, trace and location. It gives a systematic framework for file-sharing resources monitoring. And a prototype system has been developed based on the framework.

  14. Semantic Interoperability and Dynamic Resource Discovery in P2P Systems

    NASA Astrophysics Data System (ADS)

    Bianchini, Devis; de Antonellis, Valeria; Melchiori, Michele

    Service-oriented architectures and Semantic Web technologies are widely recognized as strategic means to enable effective search and access to data and services in P2P systems. In this paper we present SERVANT, a reference architecture to support SERVice-based semANTic search, by means of a semantic distributed service registry. Specifically, SERVANT supports the automatic discovery of services, available in the P2P network, apt to satisfy user's requests for information searches. The SERVANT architecture is based on: a distributed service registry, DSR, composed of semantic-enriched peer registries and semantic links between peer registries holding similar services; a Service Knowledge Evolution Manager, to update peer knowledge; a Semantic Search Assistant, to find services satisfying a user's request, to suggest possible alternative services and to propose possible related services for composition. The proposed architecture allows for efficient semantic search based on service discovery throughout the network and is able to manage P2P network evolution.

  15. A New Caching Technique to Support Conjunctive Queries in P2P DHT

    NASA Astrophysics Data System (ADS)

    Kobatake, Koji; Tagashira, Shigeaki; Fujita, Satoshi

    P2P DHT (Peer-to-Peer Distributed Hash Table) is one of typical techniques for realizing an efficient management of shared resources distributed over a network and a keyword search over such networks in a fully distributed manner. In this paper, we propose a new method for supporting conjunctive queries in P2P DHT. The basic idea of the proposed technique is to share a global information on past trials by conducting a local caching of search results for conjunctive queries and by registering the fact to the global DHT. Such a result caching is expected to significantly reduce the amount of transmitted data compared with conventional schemes. The effect of the proposed method is experimentally evaluated by simulation. The result of experiments indicates that by using the proposed method, the amount of returned data is reduced by 60% compared with conventional P2P DHT which does not support conjunctive queries.

  16. Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100

    PubMed Central

    Toledano, Víctor; Hernández-Jiménez, Enrique; Cubillos-Zapata, Carolina; Flandez, Marta; Álvarez, Enrique; Varela-Serrano, Aníbal; Cantero, Ramón; Valles, Gema; García-Rio, Francisco; López-Collazo, Eduardo

    2015-01-01

    We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NFκB2)/p100 was overexpressed after galactomannan challenge. Knocking down NFκB2/p100 using small interfering RNA (siRNA) indicated that NFκB2/p100 expression is a crucial factor in the progression of the galactomannan-induced refractoriness. The data presented in this study could be used as a modulator of inflammatory response in clinical situations where refractory state is required. PMID:26441484

  17. Shell model predictions for 124Sn double-β decay

    NASA Astrophysics Data System (ADS)

    Horoi, Mihai; Neacsu, Andrei

    2016-02-01

    Neutrinoless double-β (0 ν β β ) decay is a promising beyond standard model process. Two-neutrino double-β (2 ν β β ) decay is an associated process that is allowed by the standard model, and it was observed in about 10 isotopes, including decays to the excited states of the daughter. 124Sn was the first isotope whose double-β decay modes were investigated experimentally, and despite few other recent efforts, no signal has been seen so far. Shell model calculations were able to make reliable predictions for 2 ν β β decay half-lives. Here we use shell model calculations to predict the 2 ν β β decay half-life of 124Sn. Our results are quite different from the existing quasiparticle random-phase approximation results, and we envision that they will be useful for guiding future experiments. We also present shell model nuclear matrix elements for two potentially competing mechanisms to the 0 ν β β decay of 124Sn.

  18. Direct and indirect searches for anomalous beta decay

    NASA Astrophysics Data System (ADS)

    Nistor, Jonathan M.

    We present a treatment of time-varying nuclear transition rates intended to guide future experimental searches, focusing primarily on the concept of "self-induce decay.'' This investigation stems from a series of recent reports that suggest that the decay rates of several isotopes may have been influenced by solar activity (perhaps by solar neutrinos). A mechanism in which (anti)neutrinos can influence the decay process suggests that a sample of decaying nuclei emitting neutrinos could affect its own rate of decay. Past experiments have searched for this "self-induced decay" (SID) effect by measuring deviations from the expected decay rate for highly active samples of varying geometries. Here, we further develop a SID formalism which takes into account the activation process. In the course of the treatment, the observation is made that the SID behavior closely resembles the behavior of rate-related losses due to dead-time, and hence that standard dead-time corrections can result in the removal of possible SID-related behavior. Additionally, we discuss a long-running dark matter (DM) experiment which observes an annual signal predicted by standard DM models. Here, we consider the possibility that the annual signal seen by the DAMA collaboration, and interpreted by them as evidence for dark matter, may in fact be due to the radioactive contaminant 40K, which is known to be present in their detector. We also consider the possibility that part of the DAMA signal may arise from relic big-bang neutrinos.

  19. Heterogeneous and hyperfine interactions between valence states of molecular iodine correlating with the I(2P1/2) + I(2P1/2) dissociation limit

    NASA Astrophysics Data System (ADS)

    Baturo, Vera V.; Cherepanov, Igor N.; Lukashov, Sergey S.; Poretsky, Sergey A.; Pravilov, Anatoly M.; Zhironkin, Anatoly I.

    2016-05-01

    Detailed analysis of interactions between all 0g + , 1u, and 0u - weakly bound states of iodine molecule correlating with the I(2P1/2) + I(2P1/2) (bb) dissociation limit has been performed. For this purpose, the 0u - (bb) state has been described using analysis of rotationally resolved excitation spectra of luminescence from the g 0g - state populated in a three-step three-color perturbation facilitated excitation scheme via the 0u - state. Energies of 41 rovibrational levels, molecular constants, and potential energy curve have been determined. Energy gaps between closest rovibrational levels of the 0u - and 0g + , 1u (bb) states are found to be large, ˜6 cm-1. However, interaction of all three 0g + , 1u, and 0u - (bb) states has been observed. It has been found that the 0u - and 1u electronic states are mixed by heterogeneous interactions, while their mixing with the 0g + one is due to hyperfine interactions predominantly. Admixture coefficients and electronic matrix elements of the coupling between the 0g + ˜1u, 0g + ˜ 0u - , and 0u - ˜1u states have been estimated.

  20. Research and design of a new model for P2P live streaming system

    NASA Astrophysics Data System (ADS)

    Li, Ying; Yang, Lijuan; Liu, Haiyan

    2013-07-01

    According to the research and analysis of typical models for P2P (Peer to Peer) live streaming system, we overview and summarize the strengths and weaknesses of existing technologies. This paper proposes a new model for P2P live streaming system, which used a scheme combining unicast and multicast trees, and analysis the strategy of node management. The model combines advantages of easy maintenance of unicast tree and load balancing of multicast tree, and enhances the availability, stability and quality of service for live streaming system.

  1. Transitions of the type 2s-2p in oxygenlike Y, Zr, and Nb

    NASA Technical Reports Server (NTRS)

    Behring, W. E.; Brown, C. M.; Feldman, U.; Seely, J. F.; Reader, J.

    1986-01-01

    Transitions of the type 2s-2p in the oxygenlike ions Y XXXII, Zr XXXIII, and Nb XXXIV were identified in spectra recorded at the University of Rochester's Omega laser facility. Solid targets were spherically irradiated by 24 beams of frequency-tripled (351-nm) Nd-glass laser radiation. The spectra were photographed with a 3-m grazing-incidence spectrograph. The identified transitions of the oxygenlike ions are in the range 30 to 73 A. The wavelengths for the magnetic-dipole transitions within the 2s2p4 ground configurations of these ions are predicted from the experimental energy levels.

  2. Transfer to the continuum calculations of quasifree (p,pn) and (p,2p) reactions

    NASA Astrophysics Data System (ADS)

    Gomez-Ramos, M.; Moro, A. M.

    2016-05-01

    Nucleon removal (p, pn) and (p, 2p) reactions at intermediate energies have gained renewed attention in recent years as a tool to extract information from exotic nuclei. The information obtained from these experiments is expected to be sensitive to deeper portions of the wave function of the removed nucleon than knockout reactions with heavier targets. In this contribution, we present calculations for (p, 2p) and (p, pn) reactions performed within the so-called transfer to the continuum method (TR*). Results for stable and unstable nuclei are presented, and compared with experimental data, when available.

  3. Design and implementation of telemetry seismic data acquisition system based on embedded P2P Ethernet

    NASA Astrophysics Data System (ADS)

    Zhang, L.; Lin, J.; Chen, Z.

    2011-12-01

    A new design of telemetry seismic data acquisition system is presented which uses embedded, point to point (P2P) Ethernet networks. In our presentation, we explain the idea and motivation behind the use of P2P Ethernet topology and show the problems when such topology is used in seismic acquisition system. The presented paper focuses on the network protocols developed by us which include the generation of route table and dynamic IP address management. This new design has been implemented based on ARM and FPGA, which we have tested in laboratory and seismic exploration.

  4. Experimental and theoretical study of s 2p and c 1s spectroscopyin cs2

    SciTech Connect

    Eustatiu, I.G.; Tyliszczak, Tolek; Cooper, G.; Hitchcock, Adam; Turci, C.C.; Rocha, A.B.; Barbatti, M.; Bielschowsky, C.E.

    2006-12-01

    The generalized oscillator strength profiles in the momentumtransfer range (K) of (2 a.u.- 22p, and C 1s transitions of carbon disulfide (CS2) arepresented. Optical oscillator strengths and generalized oscillatorstrength profiles have been calculated for vertical excitation from theground X1SIGMAg+ electronic state to several C(1s) and S(2p) inner-shellelectronic excited states of CS2, using high level ab initio (HF-CI)calculations. The experimental and computed GOS profiles of CS2 arecompared and found to be generally in reasonable agreement.

  5. Are 2P/Encke, the Taurid complex NEOs and CM chondrites related?

    NASA Astrophysics Data System (ADS)

    Tubiana, C.; Snodgrass, C.; Michelsen, R.; Haack, H.; Fitzsimmons, A.; Williams, I.; Boehnhardt, H.

    2013-09-01

    Comet 2P/Encke is a short-period comet that was discovered in 1786 and has been extensively observed and studied for more than 200 years. It has an orbital period of 3.3 years and its orbit is dynamically decoupled from Jupiter's control due to gravitational interaction with terrestrial planets [6]. It is the only comet known on such an orbit, making it unique. Capture from the outer solar system onto its current orbit is very unlikely and even a continuous smooth dynamical evolution has a low probability as this requires a continuous period when it is dormant in order to avoid the volatiles from the nucleus becoming exhausted and making the current observed activity impossible. An origin in the asteroid belt is a possibility especially in view of the recently discovered main belt comets. The nucleus of 2P/Encke is dark (geometric albedo of 0.047 ± 0.023 [3]), has an effective radius of 2.4 ± 0.3 km [3] and it has polarimetric properties that are unique compared to other measured types of solar system objects, such as asteroids, TNOs, cometary dust, Centaurs [2]. The colors of 2P/Encke's nucleus are typical for comets, but no spectra of the nucleus in the visible wavelength range exist so far. The Taurid meteoroid stream has long been linked with 2P/Encke, but the activity of the comet is not strong enough to explain the number of observed meteors. It has been suggested that the meteoroid stream was caused by the break up of a larger parent body, which left comet 2P/Encke and other various small bodies along with a stream of dust. Various small near-Earth objects (NEOs) have been discovered with orbits that can be linked with 2P/Encke and the Taurid meteoroid stream [1]. Though many of the associations are spurious due to the low inclination of 2P/Encke's orbit, many NEO's have evolved in a similar way to 2P/Encke overa period of 5000 years [8] suggesting some relationship. In addition to dynamical properties, common taxonomic properties can also provide an

  6. Of humans and canines: Immunohistochemical analysis of PCNA, Bcl-2, p53, cytokeratin and ER in mammary tumours.

    PubMed

    Kumaraguruparan, R; Prathiba, D; Nagini, S

    2006-10-01

    Mammary tumours are the most common neoplasms in humans and canines. Human and canine mammary tumours share several important epidemiological, clinicopathological and biochemical features. Development of mammary tumours involves accumulation of mutant cells caused by excessive proliferation and insufficient apoptosis or dysregulation of cellular differentiation. The present study was therefore designed to investigate the expression of proliferation, differentiation, and apoptosis associated proteins together with expression of estrogen receptors (ER) in both human and canine mammary tumours. Thirty breast cancer patients categorized as pre- and postmenopausal, and 30 mammary gland tumours obtained from bitches were included in this study. The expression of proliferating cell nuclear antigen (PCNA), Bcl-2, p53, cytokeratin and ER in tumour tissues and adjacent tissues were investigated using immunohistochemical staining. While the expression of PCNA, Bcl-2, p53 and ER was significantly increased, expression of cytokeratin was significantly lower in both human as well as canine mammary tumours compared to corresponding adjacent tissues. The magnitude of the changes was however more pronounced in premenopausal patients compared to postmenopausal patients. The changes in proliferation, apoptosis and differentiation associated proteins in human and canine mammary tumours validate use of the canine model to understand the molecular mechanisms of mammary carcinogenesis. PMID:16740286

  7. Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p

    PubMed Central

    Chen, Hsin; Kuo, Chun-Chen; Kang, Hui; Howell, Audrey S.; Zyla, Trevin R.; Jin, Michelle; Lew, Daniel J.

    2012-01-01

    Actin filaments are dynamically reorganized to accommodate ever-changing cellular needs for intracellular transport, morphogenesis, and migration. Formins, a major family of actin nucleators, are believed to function as direct effectors of Rho GTPases, such as the polarity regulator Cdc42p. However, the presence of extensive redundancy has made it difficult to assess the in vivo significance of the low-affinity Rho GTPase–formin interaction and specifically whether Cdc42p polarizes the actin cytoskeleton via direct formin binding. Here we exploit a synthetically rewired budding yeast strain to eliminate the redundancy, making regulation of the formin Bni1p by Cdc42p essential for viability. Surprisingly, we find that direct Cdc42p–Bni1p interaction is dispensable for Bni1p regulation. Alternative paths linking Cdc42p and Bni1p via “polarisome” components Spa2p and Bud6p are also collectively dispensable. We identify a novel regulatory input to Bni1p acting through the Cdc42p effector, Gic2p. This pathway is sufficient to localize Bni1p to the sites of Cdc42p action and promotes a polarized actin organization in both rewired and wild-type contexts. We suggest that an indirect mechanism linking Rho GTPases and formins via Rho effectors may provide finer spatiotemporal control for the formin-nucleated actin cytoskeleton. PMID:22918946

  8. Beauty meson decays to charmonium

    NASA Astrophysics Data System (ADS)

    Ershov, Alexey Valerievich

    2001-10-01

    We study decays of beauty (B) mesons into the final states containing charmonium mesons. The data were collected by the CLEO experiment at the Cornell Electron Storage Ring from 1990 to 1999. First, we describe a technique that significantly improves the reconstruction efficiency for decays of J/ y and y (2S) mesons into a pair of leptons. This reconstruction method is used in all the analyses presented in this dissertation. Then we present a study of B decays to the χc 1 and χc2 charmonium states and compare our results with the predictions of different theoretical models of charmonium production. After that we report the first observation of the decay B --> J/ y φK, which is the first B meson decay requiring a creation of an additional ss¯ quark pair. Then we measure the B0 and B+ meson masses from B0 --> y (') K0S and B+ --> y (') K+ decays. The method employed eliminates the dominant systematic uncertainty associated with the previous B meson mass measurements at the e+e- colliders and results in a significant improvement in precision. After that we present a study of three B0 decay modes useful for time-dependent CP asymmetry measurements. In this study we reconstruct B0 --> J/ y K0S , B0 --> χc 1 K0S , and B0 --> J/ y π0 decays. The latter two decay modes are observed for the first time. We describe a K0S --> π0π0 detection technique and its application to the reconstruction of the decay B 0 --> J/ y K0S . Then we present a sensitivity study for the measurement of the mixing-induced CP violation in the neutral B meson system (parameter sin 2β) at CLEO using the method that requires a measurement of the decay time of only one meson in a B0overline B0 pair. Finally, we search for direct CP violation in decays B+/- --> J/ y K+/- and B +/- --> y (2S) K+/- . The results of this search are consistent with the Standard Model expectations and provide the first experimental test of the assumption that direct CP violation is negligible in B --> y (') K decays.

  9. Primordial nucleosynthesis with decaying particles. I - Entropy-producing decays. II - Inert decays

    NASA Technical Reports Server (NTRS)

    Scherrer, Robert J.; Turner, Michael S.

    1988-01-01

    The effect of a nonrelativistic particle X, which decays out of equilibrium, on primordial nucleosynthesis is investigated, including both the energy density of the X particle and the electromagnetic entropy production from its decay. The results are parametrized in terms of the X particle lifetime and the density parameter rm(X), where m(X) is the X particle mass and r is the ratio of X number density to photon number density prior to nucleosynthesis. The results rule out particle lifetimes greater than 1-10 s for large values of rm(X). The question of a decaying particle which produces no electromagnetic entropy in the course of its decay is addressed, and particles which produce both entropy and an inert component in their decay are discussed.

  10. Charm counting in b decays

    NASA Astrophysics Data System (ADS)

    Buskulic, D.; de Bonis, I.; Decamp, D.; Ghez, P.; Goy, C.; Lees, J.-P.; Lucotte, A.; Minard, M.-N.; Nief, J.-Y.; Odier, P.; Pietrzyk, B.; Casado, M. P.; Chmeissani, M.; Crespo, J. M.; Delfino, M.; Efthymiopoulos, I.; Fernandez, E.; Fernandez-Bosman, M.; Garrido, Ll.; Juste, A.; Martinez, M.; Orteu, S.; Padilla, C.; Park, I. C.; Pascual, A.; Perlas, J. A.; Riu, I.; Sanchez, F.; Teubert, F.; Colaleo, A.; Creanza, D.; de Palma, M.; Gelao, G.; Girone, M.; Iaselli, G.; Maggi, G.; Maggi, M.; Marinelli, N.; Nuzzo, S.; Ranieri, A.; Raso, G.; Ruggieri, F.; Selvaggi, G.; Silvestris, L.; Tempesta, P.; Tricomi, A.; Zito, G.; Huang, X.; Lin, J.; Ouyang, Q.; Wang, T.; Xie, Y.; Xu, R.; Xue, S.; Zhang, J.; Zhang, L.; Zhao, W.; Alemany, R.; Bazarko, A. O.; Bonvicini, G.; Bright-Thomas, P.; Cattaneo, M.; Cerutti, F.; Comas, P.; Coyle, P.; Drevermann, H.; Forty, R. W.; Frank, M.; Hagelberg, R.; Harvey, J.; Janot, P.; Jost, B.; Kneringer, E.; Knobloch, J.; Lehraus, I.; Lutters, G.; Martin, E. B.; Mato, P.; Minten, A.; Miquel, R.; Mir, Ll. M.; Moneta, L.; Oest, T.; Pacheco, A.; Pusztaszeri, J.-F.; Ranjard, F.; Rensing, P.; Rizzo, G.; Rolandi, L.; Schlatter, D.; Schmelling, M.; Schmitt, M.; Schneider, O.; Tejessy, W.; Tomalin, I. R.; Venturi, A.; Wachsmuth, H.; Wagner, A.; Ajaltouni, Z.; Barrès, A.; Boyer, C.; Falvard, A.; Gay, P.; Guicheney, C.; Henrard, P.; Jousset, J.; Michel, B.; Monteil, S.; Montret, J.-C.; Pallin, D.; Perret, P.; Podlyski, F.; Proriol, J.; Rosnet, P.; Rossignol, J.-M.; Fearnley, T.; Hansen, J. B.; Hansen, J. D.; Hansen, J. R.; Hansen, P. H.; Nilsson, B. S.; Rensch, B.; Wäänänen, A.; Kyriakis, A.; Markou, C.; Simopoulou, E.; Siotis, I.; Vayaki, A.; Zachariadou, K.; Blondel, A.; Bonneaud, G.; Brient, J. C.; Bourdon, P.; Rougé, A.; Rumpf, M.; Valassi, A.; Verderi, M.; Videau, H.; Candlin, D. J.; Parsons, M. I.; Focardi, E.; Parrini, G.; Corden, M.; Georgiopoulos, C.; Jaffe, D. E.; Antonelli, A.; Bencivenni, G.; Bologna, G.; Bossi, F.; Campana, P.; Capon, G.; Casper, D.; Chiarella, V.; Felici, G.; Laurelli, P.; Mannocchi, G.; Murtas, F.; Murtas, G. P.; Passalacqua, L.; Pepe-Altarelli, M.; Curtis, L.; Dorris, S. J.; Halley, A. W.; Knowles, I. G.; Lynch, J. G.; O'Shea, V.; Raine, C.; Reeves, P.; Scarr, J. M.; Smith, K.; Teixeira-Dias, P.; Thompson, A. S.; Thomson, F.; Thorn, S.; Turnbull, R. M.; Becker, U.; Geweniger, C.; Graefe, G.; Hanke, P.; Hansper, G.; Hepp, V.; Kluge, E. E.; Putzer, A.; Schmidt, M.; Sommer, J.; Stenzel, H.; Tittel, K.; Werner, S.; Wunsch, M.; Abbaneo, D.; Beuselinck, R.; Binnie, D. M.; Cameron, W.; Dornan, P. J.; Moutoussi, A.; Nash, J.; Sedgbeer, J. K.; Stacey, A. M.; Williams, M. D.; Dissertori, G.; Girtler, P.; Kuhn, D.; Rudolph, G.; Betteridge, A. P.; Bowdery, C. K.; Colrain, P.; Crawford, G.; Finch, A. J.; Foster, F.; Hughes, G.; Sloan, T.; Williams, M. I.; Galla, A.; Giehl, I.; Greene, A. M.; Hoffmann, C.; Jakobs, K.; Kleinknecht, K.; Quast, G.; Renk, B.; Rohne, E.; Sander, H.-G.; van Gemmeren, P.; Zeitnitz, C.; Aubert, J. J.; Bencheikh, A. M.; Benchouk, C.; Bonissent, A.; Bujosa, G.; Calvet, D.; Carr, J.; Diaconu, C.; Etienne, F.; Konstantinidis, N.; Payre, P.; Rousseau, D.; Talby, M.; Sadouki, A.; Thulasidas, M.; Trabelsi, K.; Aleppo, M.; Ragusa, F.; Bauer, C.; Berlich, R.; Blum, W.; Büscher, V.; Dietl, H.; Dydak, F.; Ganis, G.; Gotzhein, C.; Kroha, H.; Lütjens, G.; Lutz, G.; Männer, W.; Moser, H.-G.; Richter, R.; Rosado-Schlosser, A.; Schael, S.; Settles, R.; Seywerd, H.; Denis, R. St.; Stenzel, H.; Wiedenmann, W.; Wolf, G.; Boucrot, J.; Callot, O.; Choi, Y.; Cordier, A.; Davier, M.; Duflot, L.; Grivaz, J.-F.; Heusse, Ph.; Höcker, A.; Jacholkowska, A.; Jacquet, M.; Kim, D. W.; Le Diberder, F.; Lefrançois, J.; Lutz, A.-M.; Nikolic, I.; Park, H. J.; Schune, M.-H.; Simion, S.; Veillet, J.-J.; Videau, I.; Zerwas, D.; Azzurri, P.; Bagliesi, G.; Batignani, G.; Bettarini, S.; Bozzi, C.; Calderini, G.; Carpinelli, M.; Ciocci, M. A.; Ciulli, V.; Dell'Orso, R.; Fantechi, R.; Ferrante, I.; Foà, L.; Forti, F.; Giassi, A.; Giorgi, M. A.; Gregorio, A.; Ligabue, F.; Lusiani, A.; Marrocchesi, P. S.; Messineo, A.; Palla, F.; Sanguinetti, G.; Sciabà, A.; Spagnolo, P.; Steinberger, J.; Tenchini, R.; Tonelli, G.; Vannini, C.; Verdini, P. G.; Blair, G. A.; Bryant, L. M.; Chambers, J. T.; Gao, Y.; Green, M. G.; Medcalf, T.; Perrodo, P.; Strong, J. A.; von Wimmersperg-Toeller, J. H.; Botterill, D. R.; Clifft, R. W.; Edgecock, T. R.; Haywood, S.; Maley, P.; Norton, P. R.; Thompson, J. C.; Wright, A. E.; Bloch-Devaux, B.; Colas, P.; Emery, S.; Kozanecki, W.; Lançon, E.; Lemaire, M. C.; Locci, E.; Perez, P.; Rander, J.; Renardy, J.-F.; Roussarie, A.; Schuller, J.-P.; Schwindling, J.; Trabelsi, A.; Vallage, B.; Black, S. N.; Dann, J. H.; Johnson, R. P.; Kim, H. Y.; Litke, A. M.; McNeil, M. A.; Taylor, G.; Booth, C. N.; Boswell, R.; Brew, C. A. J.; Cartwright, S.; Combley, F.; Koksal, A.; Letho, M.; Newton, W. M.; Reeve, J.; Thompson, L. F.; Böhrer, A.; Brandt, S.; Cowan, G.; Grupen, C.; Minguet-Rodriguez, J.; Rivera, F.; Saraiva, P.; Smolik, L.; Stephan, F.; Apollonio, M.; Bosisio, L.; Della Marina, R.; Giannini, G.; Gobbo, B.; Musolino, G.; Rothberg, J.; Wasserbaech, S.; Armstrong, S. R.; Elmer, P.; Feng, Z.; Ferguson, D. P. S.; Gao, Y. S.; González, S.; Grahl, J.; Greening, T. C.; Hayes, O. J.; Hu, H.; McNamara, P. A.; Nachtman, J. M.; Orejudos, W.; Pan, Y. B.; Saadi, Y.; Scott, I. J.; Walsh, A. M.; Walsh, J.; Wu, Sau Lan; Wu, X.; Yamartino, J. M.; Zheng, M.; Zobernig, G.; Aleph Collaboration

    1996-02-01

    The inclusive production of charmed particles in Z → b overlineb decays has been measured from the yield of D0, D+, Ds+ and Λc+ decays in a sample of q overlineq events with high b purity collected with the ALEPH detector from 1992 to 1995. From these measurements, adding the charmonia production rate and an estimate of the charmed strange baryon contribution, the average number of charm quarks per b decay is determined to be nc = 1.230 ± 0.036 ± 0.038 ± 0.053, where the uncertainties are due to statistics, systematic effects and branching ratios, respectively.

  11. Glueball decay in holographic QCD

    SciTech Connect

    Hashimoto, Koji; Tan, C.-I; Terashima, Seiji

    2008-04-15

    Using holographic QCD based on D4-branes and D8-anti-D8-branes, we have computed couplings of glueballs to light mesons. We describe glueball decay by explicitly calculating its decay widths and branching ratios. Interestingly, while glueballs remain less well understood both theoretically and experimentally, our results are found to be consistent with the experimental data for the scalar glueball candidate f{sub 0}(1500). More generally, holographic QCD predicts that decay of any glueball to 4{pi}{sup 0} is suppressed, and that mixing of the lightest glueball with qq mesons is small.

  12. Optimizing VANDLE for Decay Spectroscopy

    NASA Astrophysics Data System (ADS)

    Brewer, N. T.; Taylor, S. Z.; Grzywacz, R.; Madurga, M.; Paulauskas, S. V.; Cizewski, J. A.; Peters, W. A.; Vandle Collaboration

    2013-10-01

    Understanding the decay properties of neutron rich isotopes has well established importance to the path of the r-process and to the total decay heat for reactor physics. Specifically, the half-life, branching ratio and spectra for β-n decay is of particular interest. With that in mind, we have continued attempts to improve upon the Versatile Array of Neutron Detectors at Low Energy (VANDLE) in terms of efficiency and TOF resolution through the use of new and larger scintillators. Details of the new implementation, design and characterization of the array will be shown and compared to previous results.

  13. Couplings between Chern-Simons gravities and 2p-branes

    SciTech Connect

    Miskovic, Olivera; Zanelli, Jorge

    2009-08-15

    The interaction between Chern-Simons (CS) theories and localized external sources (2p-branes) is analyzed. This interaction generalizes the minimal coupling between a point charge (0-brane) and a gauge connection. The external currents that define the 2p branes are covariantly constant (D-2p-1)-forms coupled to (2p-1) CS forms. The general expression for the sources--charged with respect to the corresponding gauge algebra--is presented, focusing on two special cases: 0-branes and (D-3)-branes. In any dimension, 0-branes are constructed as topological defects produced by a surface deficit of (D-2)-sphere in anti-de Sitter space, and they are not constant curvature spaces for D>3. They correspond to dimensionally continued black holes with negative mass. On the other hand, in the case of CS (super) gravities, the (D-3)-branes are naked conical singularities (topological defects) obtained by identification of points with a Killing vector. In 2+1 dimensions, extremal spinning branes of this type are Bogomol'nyi-Prasad-Sommerfield states. Stable (D-3)-branes are shown to exist also in higher dimensions, as well. Classical field equations are also discussed, and in the presence of sources there is a large number of inequivalent and disconnected sectors in solution space.

  14. Highly efficient acousto-optic diffraction in Sn2P2S6 crystals.

    PubMed

    Martynyuk-Lototska, I Yu; Mys, O G; Grabar, A A; Stoika, I M; Vysochanskii, Yu M; Vlokh, R O

    2008-01-01

    We have studied the acousto-optic (AO) diffraction in Sn2P2S6 crystals and found that they manifest high values of an AO figure of merit. The above crystals may therefore be used as highly efficient materials in different AO applications. PMID:18157276

  15. Query Processing in a Traceable P2P Record Exchange Framework

    NASA Astrophysics Data System (ADS)

    Li, Fengrong; Ishikawa, Yoshiharu

    As the spread of high-speed networks and the development of network technologies, P2P technologies are actively used today for information exchange in the network. While information exchange in a P2P network is quite flexible, there is an important problem — lack of reliability. Since we cannot know the details of how the data was obtained, it is hard to fully rely on it. To ensure the reliability of exchanged data, we have proposed the framework of a traceable P2P record exchange based on database technologies. In this framework, records are exchanged among autonomous peers, and each peer stores its exchange and modification histories in it. The framework supports the function of tracing queries to query the details of the obtained data. A tracing query is described in datalog and executed as a recursive query in the P2P network. In this paper, we focus on the query processing strategies for the framework. We consider two types of queries, ad hoc queries and continual queries, and present the query processing strategies for their executions.

  16. Negative magnetoresistance in a magnetic semiconducting Zintl phase: Eu(3)In(2)P(4).

    PubMed

    Jiang, Jiong; Olmstead, Marilyn M; Kauzlarich, Susan M; Lee, Han-Oh; Klavins, Peter; Fisk, Zachary

    2005-07-25

    A new rare earth metal Zintl phase, Eu(3)In(2)P(4), was synthesized by utilizing a metal flux method. The compound crystallizes in the orthorhombic space group Pnnm with the cell parameters a = 16.097(3) A, b = 6.6992(13) A, c = 4.2712(9) A, and Z = 2 (T = 90(2) K, R1 = 0.0159, wR2 = 0.0418 for all data). It is isostructural to Sr(3)In(2)P(4). The structure consists of tetrahedral dimers, [In(2)P(2)P(4/2)](6-), that form a one-dimensional chain along the c axis. Three europium atoms interact via a Eu-Eu distance of 3.7401(6) A to form a straight line triplet. Single-crystal magnetic measurements show anisotropy at 30 K and a magnetic transition at 14.5 K. High-temperature data give a positive Weiss constant, which suggests ferromagnetism, while the shape of susceptibility curves (chi vs T) suggests antiferromagnetism. Heat capacity shows a magnetic transition at 14.5 K that is suppressed with field. This compound is a semiconductor according to the temperature-dependent resistivity measurements with a room-temperature resistivity of 0.005(1) Omega m and E(g) = 0.452(4) eV. It shows negative magnetoresistance below the magnetic ordering temperature. The maximum magnetoresistance (Deltarho/rho(H)) is 30% at 2 K with H = 5 T. PMID:16022530

  17. Load Balancing Scheme on the Basis of Huffman Coding for P2P Information Retrieval

    NASA Astrophysics Data System (ADS)

    Kurasawa, Hisashi; Takasu, Atsuhiro; Adachi, Jun

    Although a distributed index on a distributed hash table (DHT) enables efficient document query processing in Peer-to-Peer information retrieval (P2P IR), the index costs a lot to construct and it tends to be an unfair management because of the unbalanced term frequency distribution. We devised a new distributed index, named Huffman-DHT, for P2P IR. The new index uses an algorithm similar to Huffman coding with a modification to the DHT structure based on the term distribution. In a Huffman-DHT, a frequent term is assigned to a short ID and allocated a large space in the node ID space in DHT. Throuth ID management, the Huffman-DHT balances the index registration accesses among peers and reduces load concentrations. Huffman-DHT is the first approach to adapt concepts of coding theory and term frequency distribution to load balancing. We evaluated this approach in experiments using a document collection and assessed its load balancing capabilities in P2P IR. The experimental results indicated that it is most effective when the P2P system consists of about 30, 000 nodes and contains many documents. Moreover, we proved that we can construct a Huffman-DHT easily by estimating the probability distribution of the term occurrence from a small number of sample documents.

  18. 76 FR 65558 - Rescission of Social Security Ruling 97-2p

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Rescission of Social Security Ruling 97-2p AGENCY: Social Security Administration. ACTION: Notice of rescission of Social Security Ruling. SUMMARY: In accordance with 20 CFR 402.35(b)(1),...

  19. Scalable P2P Overlays of Very Small Constant Degree: An Emerging Security Threat

    NASA Astrophysics Data System (ADS)

    Jelasity, Márk; Bilicki, Vilmos

    In recent years peer-to-peer (P2P) technology has been adopted by Internet-based malware as a fault tolerant and scalable communication medium for self-organization and survival. It has been shown that malicious P2P networks would be nearly impossible to uncover if they operated in a stealth mode, that is, using only a small constant number of fixed overlay connections per node for communication. While overlay networks of a small constant maximal degree are generally considered to be unscalable, we argue in this paper that it is possible to design them to be scalable, efficient and robust. This is an important finding from a security point of view: we show that stealth mode P2P malware that is very difficult to discover with state-of-the-art methods is a plausible threat. In this paper we discuss algorithms and theoretical results that support the scalability of stealth mode overlays, and we present realistic simulations using an event based implementation of a proof-of-concept system. Besides P2P botnets, our results are also applicable in scenarios where relying on a large number of overlay connections per node is not feasible because of cost or the limited number of communication channels available.

  20. P2P - POLLUTION PREVENTION PROGRESS (SYSTEMS ANALYSIS BRANCH, SUSTAINABLE TECHNOLOGY DIVISION, NRMRL)

    EPA Science Inventory

    P2P is a pollutant classification system. It currently includes a database of approximately 5600 chemicals and will classify many of these chemicals in one or more of 22 impact categories (e.g., ozone depleter, global warmer). Most classifications are based on expert judgment, bu...

  1. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR... 29 Labor 7 2014-07-01 2014-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section 1917..., DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Marine Terminal Operations § 1917.22 Hazardous cargo 2...

  2. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR... 29 Labor 7 2012-07-01 2012-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section 1917..., DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Marine Terminal Operations § 1917.22 Hazardous cargo 2...

  3. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR... 29 Labor 7 2013-07-01 2013-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section 1917..., DEPARTMENT OF LABOR (CONTINUED) MARINE TERMINALS Marine Terminal Operations § 1917.22 Hazardous cargo 2...

  4. Lepton number violation in D meson decay

    NASA Astrophysics Data System (ADS)

    Dong, Hai-Rong; Feng, Feng; Li, Hai-Bo

    2015-01-01

    The lepton number violation (LNV) process can be induced by introducing a fourth generation heavy Majorana neutrino, which is coupled to the charged leptons of the Standard Model (SM). There have been many previous studies on the leptonic number violating decay processes with this mechanism. We follow the trend to study the process: D→Kllπ with the same-sign dilepton final states. We restrict ourselves to certain neutrino mass regions, in which the heavy neutrino could be on-shell and the dominant contribution to the branching fraction comes from the resonance enhanced effect. Applying the narrow width approximation (NWA), we found that the upper limit for the branching fractions for D0 → K-l+l+π- are generally at the order of 10-12 to 10-9, if we take the most stringent upper limit bound currently available in the literature for the mixing matrix elements. We also provide the constraints, which is competitive compared to the LNV B decays, on the mixing matrix element |VeN|2 based on the upper limit of D0 → K-e+e+π- estimated from the Monte-Carlo (MC) study at BESIII. Although the constraints are worse than the ones from (0νββ) decay in the literature, the future experiment at the charm factory may yield more stringent constraints.

  5. A Novel Syndrome Affecting Multiple Mitochondrial Functions, Located by Microcell-Mediated Transfer to Chromosome 2p14-2p13

    PubMed Central

    Seyda, Agnieszka; Newbold, Robert F.; Hudson, Thomas J.; Verner, Andrei; MacKay, Neviana; Winter, Susan; Feigenbaum, Annette; Malaney, Suzann; Gonzalez-Halphen, Diego; Cuthbert, Andrew P.; Robinson, Brian H.

    2001-01-01

    We have studied cultured skin fibroblasts from three siblings and one unrelated individual, all of whom had fatal mitochondrial disease manifesting soon after birth. After incubation with 1 mM glucose, these four cell strains exhibited lactate/pyruvate ratios that were six times greater than those of controls. On further analysis, enzymatic activities of the pyruvate dehydrogenase complex, the 2-oxoglutarate dehydrogenase complex, NADH cytochrome c reductase, succinate dehydrogenase, and succinate cytochrome c reductase were severely deficient. In two of the siblings the enzymatic activity of cytochrome oxidase was mildly decreased (by ∼50%). Metabolite analysis performed on urine samples taken from these patients revealed high levels of glycine, leucine, valine, and isoleucine, indicating abnormalities of both the glycine-cleavage system and branched-chain α-ketoacid dehydrogenase. In contrast, the activities of fibroblast pyruvate carboxylase, mitochondrial aconitase, and citrate synthase were normal. Immunoblot analysis of selected complex III subunits (core 1, cyt c1, and iron-sulfur protein) and of the pyruvate dehydrogenase complex subunits revealed no visible changes in the levels of all examined proteins, decreasing the possibility that an import and/or assembly factor is involved. To elucidate the underlying molecular defect, analysis of microcell-mediated chromosome-fusion was performed between the present study's fibroblasts (recipients) and a panel of A9 mouse:human hybrids (donors) developed by Cuthbert et al. (1995). Complementation was observed between the recipient cells from both families and the mouse:human hybrid clone carrying human chromosome 2. These results indicate that the underlying defect in our patients is under the control of a nuclear gene, the locus of which is on chromosome 2. A 5-cM interval has been identified as potentially containing the critical region for the unknown gene. This interval maps to region 2p14-2p13. PMID

  6. On the interatomic electronic processes following Auger decay in neon dimer.

    PubMed

    Stoychev, Spas D; Kuleff, Alexander I; Tarantelli, Francesco; Cederbaum, Lorenz S

    2008-08-21

    The accessible relaxation channels of the electronic states of Ne(++)-Ne and Ne(3+)-Ne populated by KLL Auger decay are studied. In particular, we address the "direct" and "exchange" interatomic Coulombic decays (ICDs) and the electron-transfer-mediated decay following the population of one-site states Ne(++)(2s(-2))-Ne and Ne(++)(2s(-1)2p(-1) (1)P)-Ne. Radiative charge transfer of the low lying Ne(++)(2p(-2))-Ne states, three-electron ICD process from the Ne(++)(2s(-2))-Ne states, as well as charge transfer at the points of curve crossing of the lowest in energy Ne(3+)(2p(-3))-Ne states are also discussed. To carry out the present study, we have calculated the potential energy curves (from 1.75 to 5.00 A) of the ground state Ne(2), the core ionized state Ne(+)(1s(-1))-Ne, and the dicationic and tricationic states with energies in the range of 45-140 eV using accurate ab initio methods and basis sets. Apart from being of interest by themselves, the results obtained may be helpful in interpreting the recent measurements of interatomic electronic processes following Auger decay in neon dimer [K. Kreidi et al., J. Phys. B 41, 101002 (2008)]. PMID:19044767

  7. Formulation development and evaluation of innovative two-polymer (SR-2P) bioadhesive vaginal gel.

    PubMed

    Podaralla, Satheesh; Alt, Carsten; Shankar, Gita N

    2014-08-01

    The main objective of this investigation was to study the feasibility of developing a vaginal bioadhesive microbicide using a SRI's proprietary two-polymer gel platform (SR-2P). Several formulations were prepared with different combinations of temperature-sensitive polymer (Pluronic® F-127) and mucoadhesive polymer (Noveon® AA-1), producing gels of different characteristics. Prototype polymeric gels were evaluated for pH, osmolality, buffering capacity, and viscosity under simulated vaginal semen dilutions, and bioadhesivity using ex vivo mini pig vaginal tissues and texture analyzer. The pH of the polymeric gel formulations ranged from 5.1 to 6.4; the osmolality varied from 13 to 173 mOsm. Absolute viscosity ranged from 513 to 3,780 cPs, and was significantly reduced (1.5- to 3-fold) upon incubation with simulated vaginal and semen fluid mixture. Among the tested gels (indicated in the middle row as a molar ratio of a mixture of Noveon vs. Pluronic), only SR-2P retained gel structure upon dilution with simulated fluids and mild simulated coital stress. The pH of the SR-2P gel was maintained at about 4.6 in simulated vaginal fluid and also showed high peak force of adhesion in mini pig vaginal tissue. Furthermore, SR-2P gel caused no or only minimal irritation in a mouse vaginal irritation model. The results of this preliminary study demonstrated the potential application of SR-2P gel as a vaginal microbicide vehicle for delivery of anti-HIV agents. PMID:24781671

  8. α and 2 p 2 n emission in fast neutron-induced reactions on 60Ni

    NASA Astrophysics Data System (ADS)

    Fotiades, N.; Devlin, M.; Haight, R. C.; Nelson, R. O.; Kunieda, S.; Kawano, T.

    2015-06-01

    Background: The cross sections for populating the residual nucleus in the reaction ZAX(n,x) Z -2 A -4Y exhibit peaks as a function of incident neutron energy corresponding to the (n ,n'α ) reaction and, at higher energy, to the (n ,2 p 3 n ) reaction. The relative magnitudes of these peaks vary with the Z of the target nucleus. Purpose: Study fast neutron-induced reactions on 60Ni. Locate experimentally the nuclear charge region along the line of stability where the cross sections for α emission and for 2 p 2 n emission in fast neutron-induced reactions are comparable as a further test of reaction models. Methods: Data were taken by using the Germanium Array for Neutron-Induced Excitations. The broad-spectrum pulsed neutron beam of the Los Alamos Neutron Science Center's Weapons Neutron Research facility provided neutrons in the energy range from 1 to 250 MeV. The time-of-flight technique was used to determine the incident-neutron energies. Results: Absolute partial cross sections for production of seven discrete Fe γ rays populated in 60Ni (n ,α /2 p x n γ ) reactions with 2 ≤x ≤5 were measured for neutron energies 1 MeV2 p 2 n and 2 p 3 n emission at higher incident energies in the nuclear charge region around Fe.

  9. Genitourinary defects associated with genomic deletions in 2p15 encompassing OTX1.

    PubMed

    Jorgez, Carolina J; Rosenfeld, Jill A; Wilken, Nathan R; Vangapandu, Hima V; Sahin, Aysegul; Pham, Dung; Carvalho, Claudia M B; Bandholz, Anne; Miller, Amanda; Weaver, David D; Burton, Barbara; Babu, Deepti; Bamforth, John S; Wilks, Timothy; Flynn, Daniel P; Roeder, Elizabeth; Patel, Ankita; Cheung, Sau W; Lupski, James R; Lamb, Dolores J

    2014-01-01

    Normal development of the genitourinary (GU) tract is a complex process that frequently goes awry. In male children the most frequent congenital GU anomalies are cryptorchidism (1-4%), hypospadias (1%) and micropenis (0.35%). Bladder exstrophy and epispadias complex (BEEC) (1∶47000) occurs less frequently but significantly impacts patients' lives. Array comparative genomic hybridization (aCGH) identified seven individuals with overlapping deletions in the 2p15 region (66.0 kb-5.6 Mb). Six of these patients have GU defects, while the remaining patient has no GU defect. These deletions encompass the transcription factor OTX1. Subjects 2-7 had large de novo CNVs (2.39-6.31 Mb) and exhibited features similar to those associated with the 2p15p16.1 and 2p15p14 microdeletion syndromes, including developmental delay, short stature, and variable GU defects. Subject-1 with BEEC had the smallest deletion (66 kb), which deleted only one copy of OTX1. Otx1-null mice have seizures, prepubescent transient growth retardation and gonadal defects. Two subjects have short stature, two have seizures, and six have GU defects, mainly affecting the external genitalia. The presence of GU defects in six patients in our cohort and eight of thirteen patients reported with deletions within 2p14p16.1 (two with deletion of OTX1) suggest that genes in 2p15 are important for GU development. Genitalia defects in these patients could result from the effect of OTX1 on pituitary hormone secretion or on the regulation of SHH signaling, which is crucial for development of the bladder and genitalia. PMID:25203062

  10. Genitourinary Defects Associated with Genomic Deletions in 2p15 Encompassing OTX1

    PubMed Central

    Jorgez, Carolina J.; Rosenfeld, Jill A.; Wilken, Nathan R.; Vangapandu, Hima V.; Sahin, Aysegul; Pham, Dung; Carvalho, Claudia M. B.; Bandholz, Anne; Miller, Amanda; Weaver, David D.; Burton, Barbara; Babu, Deepti; Bamforth, John S.; Wilks, Timothy; Flynn, Daniel P.; Roeder, Elizabeth; Patel, Ankita; Cheung, Sau W.; Lupski, James R.; Lamb, Dolores J.

    2014-01-01

    Normal development of the genitourinary (GU) tract is a complex process that frequently goes awry. In male children the most frequent congenital GU anomalies are cryptorchidism (1–4%), hypospadias (1%) and micropenis (0.35%). Bladder exstrophy and epispadias complex (BEEC) (1∶47000) occurs less frequently but significantly impacts patients' lives. Array comparative genomic hybridization (aCGH) identified seven individuals with overlapping deletions in the 2p15 region (66.0 kb-5.6 Mb). Six of these patients have GU defects, while the remaining patient has no GU defect. These deletions encompass the transcription factor OTX1. Subjects 2–7 had large de novo CNVs (2.39–6.31 Mb) and exhibited features similar to those associated with the 2p15p16.1 and 2p15p14 microdeletion syndromes, including developmental delay, short stature, and variable GU defects. Subject-1 with BEEC had the smallest deletion (66 kb), which deleted only one copy of OTX1. Otx1-null mice have seizures, prepubescent transient growth retardation and gonadal defects. Two subjects have short stature, two have seizures, and six have GU defects, mainly affecting the external genitalia. The presence of GU defects in six patients in our cohort and eight of thirteen patients reported with deletions within 2p14p16.1 (two with deletion of OTX1) suggest that genes in 2p15 are important for GU development. Genitalia defects in these patients could result from the effect of OTX1 on pituitary hormone secretion or on the regulation of SHH signaling, which is crucial for development of the bladder and genitalia. PMID:25203062

  11. Radiative Leptonic B Decays

    SciTech Connect

    Chen, Edward Tann

    2007-01-01

    We present the results of a search for B+ meson decays into γℓ+v, where ℓ = e,μ. We use a sample of 232 million B$\\bar{B}$ meson pairs recorded at the Υ(4S) resonance with the BABAR detector at the PEP-II B factory. We measure a partial branching fraction Δβ in a restricted region of phase space that reduces the effect of theoretical uncertainties, requiring the lepton energy to be in the range 1.875 and 2.850 GeV, the photon energy to be in the range 0.45 and 2.35 GeV, and the cosine of the angle between the lepton and photon momenta to be less than -0.36, with all quantities computed in the Υ(4S) center-of-mass frame. We find Δβ(B+ → γℓ+v) = (-0.31.5+1.3(statistical) -0.6+0.6(systematic) ± 0.1(theoretical)) x 10-6, under the assumption of lepton universality. Interpreted as a 90% confidence-level Bayesian upper limit, the result corresponds to 1.7 x 10-6 for a prior at in amplitude, and 2.3 x 10-6 for a prior at in branching fraction.

  12. Role of p14ARF-HDM2-p53 axis in SOX6-mediated tumor suppression.

    PubMed

    Wang, J; Ding, S; Duan, Z; Xie, Q; Zhang, T; Zhang, X; Wang, Y; Chen, X; Zhuang, H; Lu, F

    2016-03-31

    Sex-determining region Y box 6 (SOX6) has been described as a tumor-suppressor gene in several cancers. Our previous work has suggested that SOX6 upregulated p21(Waf1/Cip1)(p21) expression in a p53-dependent manner; however, the underlying mechanism has remained elusive. In this study, we confirmed that SOX6 can suppress cell proliferation in vitro and in vivo by stabilizing p53 protein and subsequently upregulating p21. Co-immunoprecipitation and immunocytofluorescence assays demonstrated that SOX6 can promote formation of the p14ARF-HDM2-p53 ternary complex by promoting translocation of p14ARF (p14 alternate reading frame tumor suppressor) to the nucleoplasm, thereby inhibiting HDM2-mediated p53 nuclear export and degradation. Chromatin immunoprecipitation combined with PCR assay proved that SOX6 can bind to a potential binding site in the regulatory region of the c-Myc gene. Furthermore, we confirmed that SOX6 can downregulate the expression of c-Myc, as well as its direct target gene nucleophosmin 1 (NPM1), and that the SOX6-induced downregulation of NPM1 is linked to translocation of p14ARF to the nucleoplasm. Finally, we showed that the highly conserved high-mobility group (HMG) domain of SOX6 is required for SOX6-mediated p53 stabilization and tumor inhibitory activity. Collectively, these results reveal a new mechanism of SOX6-mediated tumor suppression involving p21 upregulation via the p14ARF-HDM2-p53 axis in an HMG domain-dependent manner. PMID:26119940

  13. Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells.

    PubMed

    Schwingshackl, Andreas; Teng, Bin; Ghosh, Manik; West, Alina Nico; Makena, Patrudu; Gorantla, Vijay; Sinclair, Scott E; Waters, Christopher M

    2012-01-01

    Hyperoxia can lead to a myriad of deleterious effects in the lung including epithelial damage and diffuse inflammation. The specific mechanisms by which hyperoxia promotes these pathological changes are not completely understood. Activation of ion channels has been proposed as one of the mechanisms required for cell activation and mediator secretion. The two-pore-domain K(+) channel (K2P) Trek-1 has recently been described in lung epithelial cells, but its function remains elusive. In this study we hypothesized that hyperoxia affects expression of Trek-1 in alveolar epithelial cells and that Trek-1 is involved in regulation of cell proliferation and cytokine secretion. We found gene expression of several K2P channels in mouse alveolar epithelial cells (MLE-12), and expression of Trek-1 was significantly downregulated in cultured cells and lungs of mice exposed to hyperoxia. Similarly, proliferation cell nuclear antigen (PCNA) and Cyclin D1 expression were downregulated by exposure to hyperoxia. We developed an MLE-12 cell line deficient in Trek-1 expression using shRNA and found that Trek-1 deficiency resulted in increased cell proliferation and upregulation of PCNA but not Cyclin D1. Furthermore, IL-6 and regulated on activation normal T-expressed and presumably secreted (RANTES) secretion was decreased in Trek-1-deficient cells, whereas release of monocyte chemoattractant protein-1 was increased. Release of KC/IL-8 was not affected by Trek-1 deficiency. Overall, deficiency of Trek-1 had a more pronounced effect on mediator secretion than exposure to hyperoxia. This is the first report suggesting that the K(+) channel Trek-1 could be involved in regulation of alveolar epithelial cell proliferation and cytokine secretion, but a direct association with hyperoxia-induced changes in Trek-1 levels remains elusive. PMID:21949155

  14. The decay of hot nuclei

    SciTech Connect

    Moretto, L.G.; Wozniak, G.J.

    1988-11-01

    The formation of hot compound nuclei in intermediate-energy heavy ion reactions is discussed. The statistical decay of such compound nuclei is responsible for the abundant emission of complex fragments and high energy gamma rays. 43 refs., 23 figs.

  15. Questions Students Ask: Beta Decay.

    ERIC Educational Resources Information Center

    Koss, Jordan; Hartt, Kenneth

    1988-01-01

    Answers a student's question about the emission of a positron from a nucleus. Discusses the problem from the aspects of the uncertainty principle, beta decay, the Fermi Theory, and modern physics. (YP)

  16. The Search for Proton Decay.

    ERIC Educational Resources Information Center

    Marshak, Marvin L.

    1984-01-01

    Provides the rationale for and examples of experiments designed to test the stability of protons and bound neutrons. Also considers the unification question, cosmological implications, current and future detectors, and current status of knowledge on proton decay. (JN)

  17. Overview of rare K decays

    SciTech Connect

    Littenberg, L.

    1995-05-01

    The status and future prospects of searches for and studies of forbidden and highly suppressed K decays are reviewed. Here the author discusses three areas of recent activity in rare K decay. These are lepton-flavor violating decays, which are entirely forbidden in the Standard Model, K{sub S} {yields} {pi}{sup +}{pi}{sup {minus}}{pi}{sup 0}, which is of interest from the point of view of CP-violation, and `one loop` decays of the form K{sup 0,{+-}} {yields} ({pi}{sup 0,{+-}})l{bar l}, that can throw light on Standard Model CP-violation and determine parameters such as V{sub td}.

  18. CP violation in K decays

    SciTech Connect

    Gilman, F.J.

    1989-05-01

    Recent theoretical and experimental progress on the manifestation of CP violation in K decays, and toward understanding whether CP violation originates in a phase, or phases, in the weak mixing matrix of quarks is reviewed. 23 refs., 10 figs.

  19. Phospholipid Flippases Lem3p-Dnf1p and Lem3p-Dnf2p Are Involved in the Sorting of the Tryptophan Permease Tat2p in Yeast*

    PubMed Central

    Hachiro, Takeru; Yamamoto, Takaharu; Nakano, Kenji; Tanaka, Kazuma

    2013-01-01

    The type 4 P-type ATPases are flippases that generate phospholipid asymmetry in membranes. In budding yeast, heteromeric flippases, including Lem3p-Dnf1p and Lem3p-Dnf2p, translocate phospholipids to the cytoplasmic leaflet of membranes. Here, we report that Lem3p-Dnf1/2p are involved in transport of the tryptophan permease Tat2p to the plasma membrane. The lem3Δ mutant exhibited a tryptophan requirement due to the mislocalization of Tat2p to intracellular membranes. Tat2p was relocalized to the plasma membrane when trans-Golgi network (TGN)-to-endosome transport was inhibited. Inhibition of ubiquitination by mutations in ubiquitination machinery also rerouted Tat2p to the plasma membrane. Lem3p-Dnf1/2p are localized to endosomal/TGN membranes in addition to the plasma membrane. Endocytosis mutants, in which Lem3p-Dnf1/2p are sequestered to the plasma membrane, also exhibited the ubiquitination-dependent missorting of Tat2p. These results suggest that Tat2p is ubiquitinated at the TGN and missorted to the vacuolar pathway in the lem3Δ mutant. The NH2-terminal cytoplasmic region of Tat2p containing ubiquitination acceptor lysines interacted with liposomes containing acidic phospholipids, including phosphatidylserine. This interaction was abrogated by alanine substitution mutations in the basic amino acids downstream of the ubiquitination sites. Interestingly, a mutant Tat2p containing these substitutions was missorted in a ubiquitination-dependent manner. We propose the following model based on these results; Tat2p is not ubiquitinated when the NH2-terminal region is bound to membrane phospholipids, but if it dissociates from the membrane due to a low level of phosphatidylserine caused by perturbation of phospholipid asymmetry in the lem3Δ mutant, Tat2p is ubiquitinated and then transported from the TGN to the vacuole. PMID:23250744

  20. Proton decay and nuclear dynamics

    SciTech Connect

    Alvioli, M.; Strikman, M.; Benhar, O.; Ericson, M.

    2010-04-15

    The kinematics of the decay of a bound proton is governed by the proton spectral function. We evaluate this quantity in {sup 16}O using the information from nuclear physics experiments. It also includes a correlated part. The reliability of this evaluation is sufficient to open the possibility of correlated cuts in the missing mass and momentum variables to identify the decay events from the bound protons with a possible increase of the signal-to-noise ratio.

  1. Thermal corrections to Electroweak Decays

    NASA Astrophysics Data System (ADS)

    Masood, Samina

    2016-03-01

    We study the electroweak processes at finite temperatures. This includes the decay rates of electroweak gauge bosons and beta decays. Major thermal corrections come from QED type radiative corrections. Heavy mass of the electroweak gauge bosons helps to suppress the radiative corrections due to the electroweak gauge boson loops. Therefore, dominant thermal corrections are due to the photon loops. We also discuss the relevance of our results to astrophysics and cosmology.

  2. Semileptonic B-Meson Decays

    SciTech Connect

    Volk, Alexei; /Dresden, Tech. U.

    2010-08-26

    The study of the semileptonic B-meson decays is the most accessible and cleanest way to determine the CKM matrix elements |V{sub cb}| and V{sub ub}. These decays also provide experimental access to study the QCD form-factors, heavy quark masses, and HQE parameters. The theoretical description of semileptonic B-meson decays at the parton level is very simple because there is no interaction between leptonic and hadronic currents. At the hadron level one needs to introduce corrections due to the strong interaction between quarks. Especially in the description of the inclusive B-meson decays the motion of the b-quark inside the B-meson plays a crucial role. All these effects are described in the frameworks of Heavy Quark Effective Theory (HQET) and Lattice QCD (LQCD). We give an overview about results of studies of semileptonic B-meson decays collected with the BABAR and Belle detectors at the PEP-II and the KEKB e{sup +}e{sup -}-storage rings. We present recent results on hadronic moments measured in inclusive B {yields} X{sub c}lv and B {yields} X{sub u}lv decays and extracted heavy quark masses m{sub b} and m{sub c} and dominant non-perturbative Heavy Quark Expansion (HQE) parameters. We also report the measurements of the CKM matrix elements |V{sub cb}| and |V{sub ub}| in inclusive and in exclusive semileptonic B-meson decays. We describe the studies of the form-factor parameters for the decay B{sup 0} {yields} D*{sup -}l{sup +}v and present the measurement of the B{sup 0} {yields} {pi}{sup -}l{sup +}v form-factor shape.

  3. Reionization and dark matter decay

    NASA Astrophysics Data System (ADS)

    Oldengott, Isabel M.; Boriero, Daniel; Schwarz, Dominik J.

    2016-08-01

    Cosmic reionization and dark matter decay can impact observations of the cosmic microwave sky in a similar way. A simultaneous study of both effects is required to constrain unstable dark matter from cosmic microwave background observations. We compare two reionization models with and without dark matter decay. We find that a reionization model that fits also data from quasars and star forming galaxies results in tighter constraints on the reionization optical depth τreio, but weaker constraints on the spectral index ns than the conventional parametrization. We use the Planck 2015 data to constrain the effective decay rate of dark matter to Γeff < 2.9 × 10‑25/s at 95% C.L. This limit is robust and model independent. It holds for any type of decaying dark matter and it depends only weakly on the chosen parametrization of astrophysical reionization. For light dark matter particles that decay exclusively into electromagnetic components this implies a limit of Γ < 5.3 × 10‑26/s at 95% C.L. Specifying the decay channels, we apply our result to the case of keV-mass sterile neutrinos as dark matter candidates and obtain constraints on their mixing angle and mass, which are comparable to the ones from the diffuse X-ray background.

  4. RNA decay machines: the exosome.

    PubMed

    Chlebowski, Aleksander; Lubas, Michał; Jensen, Torben Heick; Dziembowski, Andrzej

    2013-01-01

    The multisubunit RNA exosome complex is a major ribonuclease of eukaryotic cells that participates in the processing, quality control and degradation of virtually all classes of RNA in Eukaryota. All this is achieved by about a dozen proteins with only three ribonuclease activities between them. At first glance, the versatility of the pathways involving the exosome and the sheer multitude of its substrates are astounding. However, after fifteen years of research we have some understanding of how exosome activity is controlled and applied inside the cell. The catalytic properties of the eukaryotic exosome are fairly well described and attention is now drawn to how the interplay between these activities impacts cell physiology. Also, it has become evident that exosome function relies on many auxiliary factors, which are intensely studied themselves. In this way, the focus of exosome research is slowly leaving the test tube and moving back into the cell. The exosome also has an interesting evolutionary history, which is evident within the eukaryotic lineage but only fully appreciated when considering similar protein complexes found in Bacteria and Archaea. Thus, while we keep this review focused on the most comprehensively described yeast and human exosomes, we shall point out similarities or dissimilarities to prokaryotic complexes and proteins where appropriate. The article is divided into three parts. In Part One we describe how the exosome is built and how it manifests in cells of different organisms. In Part Two we detail the enzymatic properties of the exosome, especially recent data obtained for holocomplexes. Finally, Part Three presents an overview of the RNA metabolism pathways that involve the exosome. This article is part of a Special Issue entitled: RNA Decay mechanisms. PMID:23352926

  5. K-shell auger decay of atomic oxygen

    SciTech Connect

    Stolte, W.C.; Lu, Y.; Samson, J.A.R.

    1997-04-01

    The aim of the present research is to understand the interaction between the ejected photoelectron and Auger electron produced by the Auger decay of a 1s hole in atomic oxygen, and to understand the influence this interaction has on the shape of the ionization cross sections. To accomplish this the authors have measured the relative ion yields (ion/photon) in the vicinity of the oxygen K-shell (525 - 533 eV) for O{sup +} and O{sup 2+}. The measurements were performed at the ALS on beamline, 6.3.2. The atomic oxygen was produced by passing molecular oxygen through a microwave-driven discharge. A Rydberg analysis of the two series leading to the [1s]2s{sup 2}2p{sup 4}({sup 4}P) and [1s]2s{sup 2}2p{sup 4}({sup 2}P) limits were obtained. This analysis shows some differences to the recently published results by Menzel et al. The energy position of the main 1s{sup 1}2s{sup 2}2p{sup 5}({sup 3}P) resonance differs by approximately 1 eV from the authors value, all members of the ({sup 2}P)np series differ by 0.3 eV, but the members of the ({sup 4}P)np series agree. The molecular resonance at 530.5 eV and those between 539 eV and 543 eV, measured with the microwave discharge off show identical results in both experiments.

  6. Kinetics and Thermochemistry of Reversible Adduct Formation in the Reaction of Cl((sup 2)P(sub J)) with CS2

    NASA Technical Reports Server (NTRS)

    Nicovich, J. M.; Shackelford, C. J.; Wine, P. H.

    1997-01-01

    Reversible adduct formation in the reaction of Cl((sup 2)P(sub J)) with CS2 has been observed over the temperature range 193-258 K by use of time-resolved resonance fluorescence spectroscopy to follow the decay of pulsed-laser-generated Cl((sup 2)P(sub J)) into equilbrium with CS2Cl. Rate coefficients for CS2Cl formation and decomposition have been determined as a function of temperature and pressure; hence, the equilbrium constant has been determined as a function of temperature. A second-law analysis of the temperature dependence of Kp and heat capacity corrections calculated with use of an assumed CS2Cl structure yields the following thermodynamic parameters for the association reaction: Delta-H(sub 298) = -10.5 +/- 0.5 kcal/mol, Delta-H(sub 0) = -9.5 +/- 0.7 kcal/mol, Delta-S(sub 298) = -26.8 +/- 2.4 cal/mol.deg., and Delta-H(sub f,298)(CS2Cl) = 46.4 +/- 0.6 kcal/mol. The resonance fluorescence detection scheme has been adapted to allow detection of Cl((sup 2)P(sub J)) in the presence of large concentrations of O2, thus allowing the CS2Cl + Cl + O2 reaction to be investigated. We find that the rate coefficient for CS2Cl + O2 reaction via all channels that do not generate Cl((sup 2)P(sub J)) is less than 2.5 x 10(exp-16) cu cm/(molecule.s) at 293 K and 300-Torr total pressure and that the total rate coefficient is less than 2 x 10 (exp -15) cu cm/(molecule.s) at 230 K and 30-Torr total pressure. Evidence for reversible adduct formation in the reaction of Cl((sup 2)P(sub J)) with COS was sought but not observed, even at temperatures as low as 194 K.

  7. Probing new physics models of neutrinoless double beta decay with SuperNEMO

    NASA Astrophysics Data System (ADS)

    Arnold, R.; Augier, C.; Baker, J.; Barabash, A. S.; Basharina-Freshville, A.; Bongrand, M.; Brudanin, V.; Caffrey, A. J.; Cebrián, S.; Chapon, A.; Chauveau, E.; Dafni, T.; Deppisch, F. F.; Diaz, J.; Durand, D.; Egorov, V.; Evans, J. J.; Flack, R.; Fushima, K.-I.; Irastorza, I. García; Garrido, X.; Gómez, H.; Guillon, B.; Holin, A.; Holy, K.; Horkley, J. J.; Hubert, P.; Hugon, C.; Iguaz, F. J.; Ishihara, N.; Jackson, C. M.; Jullian, S.; Kauer, M.; Kochetov, O.; Konovalov, S. I.; Kovalenko, V.; Lamhamdi, T.; Lang, K.; Lutter, G.; Luzón, G.; Mamedov, F.; Marquet, C.; Mauger, F.; Monrabal, F.; Nachab, A.; Nasteva, I.; Nemchenok, I.; Nguyen, C. H.; Nomachi, M.; Nova, F.; Ohsumi, H.; Pahlka, R. B.; Perrot, F.; Piquemal, F.; Povinec, P. P.; Richards, B.; Ricol, J. S.; Riddle, C. L.; Rodríguez, A.; Saakyan, R.; Sarazin, X.; Sedgbeer, J. K.; Serra, L.; Shitov, Y.; Simard, L.; Šimkovic, F.; Söldner-Rembold, S.; Štekl, I.; Sutton, C. S.; Tamagawa, Y.; Thomas, J.; Timkin, V.; Tretyak, V.; Tretyak, V. I.; Umatov, V. I.; Vanyushin, I. A.; Vasiliev, R.; Vasiliev, V.; Vorobel, V.; Waters, D.; Yahlali, N.; Žukauskas, A.

    2010-12-01

    The possibility to probe new physics scenarios of light Majorana neutrino exchange and right-handed currents at the planned next generation neutrinoless double β decay experiment SuperNEMO is discussed. Its ability to study different isotopes and track the outgoing electrons provides the means to discriminate different underlying mechanisms for the neutrinoless double β decay by measuring the decay half-life and the electron angular and energy distributions.

  8. Quantum Decay of the 'False Vacuum' and Pair Creation of Soliton Domain Walls

    SciTech Connect

    Miller, John H. Jr.

    2011-03-28

    Quantum decay of metastable states ('false vacua') has been proposed as a mechanism for bubble nucleation of new universes and phase transitions in the early universe. Experiments indicate the occurrence of false vacuum decay, within a region bounded by soliton domain walls that nucleate via quantum tunneling, in a highly anisotropic condensed matter system. This phenomenon provides a compelling example of false vacuum decay in the laboratory.

  9. Frontobasal gray matter loss is associated with the TREM2 p.R47H variant.

    PubMed

    Luis, Elkin O; Ortega-Cubero, Sara; Lamet, Isabel; Razquin, Cristina; Cruchaga, Carlos; Benitez, Bruno A; Lorenzo, Elena; Irigoyen, Jaione; Pastor, Maria A; Pastor, Pau

    2014-12-01

    A rare heterozygous TREM2 variant p.R47H (rs75932628) has been associated with an increased risk for Alzheimer's disease (AD). We aimed to investigate the clinical presentation, neuropsychological profile, and regional pattern of gray matter and white matter loss associated with the TREM2 variant p.R47H, and to establish which regions best differentiate p.R47H carriers from noncarriers in 2 sample sets (Spanish and Alzheimer's Disease Neuroimaging Initiative, ADNI1). This was a cross-sectional study including a total number of 16 TREM2 p.R47H carriers diagnosed with AD or mild cognitive impairment, 75 AD p.R47H noncarriers and 75 cognitively intact TREM2 p.R47H noncarriers. Spanish AD TREM2 p.R47H carriers showed apraxia (9 of 9) and psychiatric symptoms such as personality changes, anxiety, paranoia, or fears more frequently than in AD noncarriers (corrected p = 0.039). For gray matter and white matter volumetric brain magnetic resonance imaging voxelwise analyses, we used statistical parametric mapping (SPM8) based on the General Linear Model. We used 3 different design matrices with a full factorial design. Voxel-based morphometry analyses were performed separately in the 2 sample sets. The absence of interset statistical differences allowed us to perform joint and conjunction analyses. Independent voxel-based morphometry analysis of the Spanish set as well as conjunction and joint analyses revealed substantial gray matter loss in orbitofrontal cortex and anterior cingulate cortex with relative preservation of parietal lobes in AD and/or mild cognitive impairment TREM2 p.R47H carriers, suggesting that TREM2 p.R47H variant is associated with certain clinical and neuroimaging AD features in addition to the increased TREM2 p.R47H atrophy in temporal lobes as described previously. The high frequency of pathologic behavioral symptoms, combined with a preferential frontobasal gray matter cortical loss, suggests that frontobasal and temporal regions could be more

  10. Gas-to-cluster effects in S 2p-excited SF{sub 6}

    SciTech Connect

    Flesch, Roman; Serdaroglu, Ertugrul; Ruehl, Eckart; Brykalova, Xenia O.; Kan, Elena I.; Klyushina, Ekaterina S.; Krivosenko, Yuri S.; Pavlychev, Andrey A.

    2013-04-14

    High resolution X-ray spectroscopic studies on free SF{sub 6} molecules and SF{sub 6} clusters near the S 2p ionization thresholds are reported. Spectral changes occurring in clusters for the intense molecular-like S 2p{sub 1/2,3/2}{yields} 6a{sub 1g}-, 2t{sub 2g}-, and 4e{sub g}-resonances are examined in detail. Neither gas-to-cluster spectral shifts nor changes in peak shape are observed for the pre-edge 6a{sub 1g}-band. Significant changes in band shape and distinct gas-to-cluster shifts occur in the S 2p{sub 1/2,3/2}{yields} 2t{sub 2g}- and 4e{sub g}-transitions. These are found in the S 2p-ionization continua. The quasiatomic approach is used to assign the experimental results. It is shown that a convolution of asymmetric and symmetric contributions from Lorentzian and Gaussian line shapes allows us to model the spectral distribution of oscillator strength for the S 2p{sub 1/2,3/2}{yields} 2t{sub 2g}-, and 4e{sub g}-transitions. The asymmetry is due to trapping of the photoelectron within the finite size potential barrier. The Lorentzian contribution is found to be dominating in the line shape of the S 2p{yields} 2t{sub 2g}- and 4e{sub g}-bands. The spectroscopic parameters of the spin-orbit components of both the 2t{sub 2g}- and 4e{sub g}-bands are extracted and their gas-to-cluster changes are analyzed. The photoelectron trapping times in free and clustered SF{sub 6} molecules are determined. Specifically, it is shown that spectral changes in clusters reflected in core-to-valence-transitions are due to a superposition of the singly scattered photoelectron waves at the neighboring molecules with the primary and multiply scattered waves within the molecular cage.

  11. Uniform bipolar resistive switching properties with self-compliance effect of Pt/TiO{sub 2}/p-Si devices

    SciTech Connect

    Zou, Lilan; Hu, Wei; Fu, Jianhui; Qin, Ni; Li, Shuwei; Bao, Dinghua

    2014-03-15

    We report uniform bipolar resistive switching characteristic with self-compliance effect of Pt/TiO{sub 2}/p-Si devices in which TiO{sub 2} thin films were prepared directly on p-Si substrates by chemical solution deposition method. The resistive switching parameters of the Pt/TiO{sub 2}/p-Si cell obtained, such as distribution of threshold voltages, retention time, as well as resistance variation of high resistance state (HRS) and low resistance state (LRS), were investigated, and the conduction mechanisms of HRS and LRS were analyzed. The conductive mechanism at LRS and low voltage region of HRS was dominated by Ohmic law. At the high voltage region of HRS, the conductive mechanism followed the space charge limited current theory. The resistive switching phenomenon can be explained by electron trapping and de-trapping process, in which the defects (most probably oxygen vacancies) act as electron traps. Our study suggests that using p-type silicon as bottom electrode can provide a simple method for fabricating a resistive random access memory with self-compliance function. In addition, the Pt/TiO{sub 2}/p-Si configuration is compatible with complementary metal oxide semiconductor process.

  12. Bacteria Absorption-Based Mn2P2O7-Carbon@Reduced Graphene Oxides for High-Performance Lithium-Ion Battery Anodes.

    PubMed

    Yang, Yuhua; Wang, Bin; Zhu, Jingyi; Zhou, Jun; Xu, Zhi; Fan, Ling; Zhu, Jian; Podila, Ramakrishna; Rao, Apparao M; Lu, Bingan

    2016-05-24

    The development of freestanding flexible electrodes with high capacity and long cycle-life is a central issue for lithium-ion batteries (LIBs). Here, we use bacteria absorption of metallic Mn(2+) ions to in situ synthesize natural micro-yolk-shell-structure Mn2P2O7-carbon, followed by the use of vacuum filtration to obtain Mn2P2O7-carbon@reduced graphene oxides (RGO) papers for LIBs anodes. The Mn2P2O7 particles are completely encapsulated within the carbon film, which was obtained by carbonizing the bacterial wall. The resulting carbon microstructure reduces the electrode-electrolyte contact area, yielding high Coulombic efficiency. In addition, the yolk-shell structure with its internal void spaces is ideal for sustaining volume expansion of Mn2P2O7 during charge/discharge processes, and the carbon shells act as an ideal barrier, limiting most solid-electrolyte interphase formation on the surface of the carbon films (instead of forming on individual particles). Notably, the RGO films have high conductivity and robust mechanical flexibility. As a result of our combined strategies delineated in this article, our binder-free flexible anodes exhibit high capacities, long cycle-life, and excellent rate performance. PMID:27139149

  13. β-Decay Half-Lives of 110 Neutron-Rich Nuclei across the N=82 Shell Gap: Implications for the Mechanism and Universality of the Astrophysical r Process.

    PubMed

    Lorusso, G; Nishimura, S; Xu, Z Y; Jungclaus, A; Shimizu, Y; Simpson, G S; Söderström, P-A; Watanabe, H; Browne, F; Doornenbal, P; Gey, G; Jung, H S; Meyer, B; Sumikama, T; Taprogge, J; Vajta, Zs; Wu, J; Baba, H; Benzoni, G; Chae, K Y; Crespi, F C L; Fukuda, N; Gernhäuser, R; Inabe, N; Isobe, T; Kajino, T; Kameda, D; Kim, G D; Kim, Y-K; Kojouharov, I; Kondev, F G; Kubo, T; Kurz, N; Kwon, Y K; Lane, G J; Li, Z; Montaner-Pizá, A; Moschner, K; Naqvi, F; Niikura, M; Nishibata, H; Odahara, A; Orlandi, R; Patel, Z; Podolyák, Zs; Sakurai, H; Schaffner, H; Schury, P; Shibagaki, S; Steiger, K; Suzuki, H; Takeda, H; Wendt, A; Yagi, A; Yoshinaga, K

    2015-05-15

    The β-decay half-lives of 110 neutron-rich isotopes of the elements from _{37}Rb to _{50}Sn were measured at the Radioactive Isotope Beam Factory. The 40 new half-lives follow robust systematics and highlight the persistence of shell effects. The new data have direct implications for r-process calculations and reinforce the notion that the second (A≈130) and the rare-earth-element (A≈160) abundance peaks may result from the freeze-out of an (n,γ)⇄(γ,n) equilibrium. In such an equilibrium, the new half-lives are important factors determining the abundance of rare-earth elements, and allow for a more reliable discussion of the r process universality. It is anticipated that universality may not extend to the elements Sn, Sb, I, and Cs, making the detection of these elements in metal-poor stars of the utmost importance to determine the exact conditions of individual r-process events. PMID:26024165

  14. Role of five-quark components in radiative and strong decays of the LAMBDA(1405) resonance

    SciTech Connect

    An, C. S.; Saghai, B.

    2010-04-15

    Within an extended chiral constituent quark model, the three- and five-quark structure of the S{sub 01} resonance LAMBDA(1405) is investigated. Helicity amplitudes for electromagnetic decays [LAMBDA(1405)->LAMBDA(1116)gamma, SIGMA(1194)gamma] and transition amplitudes for strong decays [LAMBDA(1405)->SIGMA(1194)pi, K{sup -}p] are derived, as well as the relevant decay widths. The experimental value for the strong decay width, GAMMA{sub LAMBDA}{sub (1405)-}>{sub (SIGMA{sub pi})}{sup o} =50+-2 MeV, is well reproduced with about 50% of a five-quark admixture in the LAMBDA(1405). Important effects owing to the configuration mixing among LAMBDA{sub 1}{sup 2}P{sub A}, LAMBDA{sub 8}{sup 2}P{sub M}, and LAMBDA{sub 8}{sup 4}P{sub M} are found. In addition, transitions between the three- and the five-quark components in the baryons turn out to be significant in both radiative and strong decays of the LAMBDA(1405) resonance.

  15. Optoelectronic devices based on MoTe2 p-n junction

    NASA Astrophysics Data System (ADS)

    Bie, Ya-Qing; Heuck, Mikkel; Furchi, Marco; Grosso, Gabriele; Zheng, Jiabao; Cao, Yuan; Navarro-Moratalla, Efren; Englund, Dirk; Jarillo-Herrero, Pablo

    2D transition metal dichalcogenides (2D-TMD), such as MoS2, have been verified with many remarkable physical properties, which include an indirect to direct band transition as a function of thickness and a valley dependent spin polarization. One of the 2D-TMD family members, 2H-MoTe2 has been shown to be a direct bandgap semiconductor as a monolayer and bilayer with a near infrared (NIR) bandgap of about 1.1eV. However, optoelectronic devices based on MoTe2 were so far not experimentally demonstrated. Here, we will present a high on-off ratio MoTe2 p-n junction enabled by a hexagonal boron nitride encapsulation technique. Our study of the MoTe2 p-n junction devices sheds light on designing efficient NIR optoelectronic devices such as photodetectors and energy harvesting cells and light emitters.

  16. Static and dynamical magnetic properties of the itinerant ferromagnet LaCo2P2

    NASA Astrophysics Data System (ADS)

    Imai, Masaki; Michioka, Chishiro; Ueda, Hiroaki; Yoshimura, Kazuyoshi

    2015-05-01

    We synthesized single crystals of an itinerant ferromagnet LaCo2P2 with ThCr2Si2 -type structure and studied their magnetism by magnetization and 31P NMR measurements. We measured Knight shift K and spin-lattice relaxation rate divided by temperature 1 /T1T with the applied fields parallel to the a and c axes, and estimated spin fluctuations in the a b plane and c . In addition, we evaluated spin fluctuations from the result of magnetization data with a three-dimensional ferromagnetic model. There is little anisotropy in evaluated spin fluctuations in the a b plane and c . Spin fluctuations of LaCo2P2 have a three-dimensional character and can be understood in the framework of the self-consistent renormalization theory of spin fluctuations.

  17. PISA: Federated Search in P2P Networks with Uncooperative Peers

    NASA Astrophysics Data System (ADS)

    Ren, Zujie; Shou, Lidan; Chen, Gang; Chen, Chun; Bei, Yijun

    Recently, federated search in P2P networks has received much attention. Most of the previous work assumed a cooperative environment where each peer can actively participate in information publishing and distributed document indexing. However, little work has addressed the problem of incorporating uncooperative peers, which do not publish their own corpus statistics, into a network. This paper presents a P2P-based federated search framework called PISA which incorporates uncooperative peers as well as the normal ones. In order to address the indexing needs for uncooperative peers, we propose a novel heuristic query-based sampling approach which can obtain high-quality resource descriptions from uncooperative peers at relatively low communication cost. We also propose an effective method called RISE to merge the results returned by uncooperative peers. Our experimental results indicate that PISA can provide quality search results, while utilizing the uncooperative peers at a low cost.

  18. MLP2P: to build multilayer peer-to-peer search topology

    NASA Astrophysics Data System (ADS)

    Tan, Zhenhua; Zhu, Zhiliang; Yang, Guangming

    2011-10-01

    Peer-to-Peer network takes more and more important role in the internet life and is studied by more and more researchers. This paper constructs multi-layer topologies according to users' requirements based on existing algorithms and p2p routing topology. From the existing base topology, new virtual topology rules can be constructed as required in which each virtual node corresponds to a node in the original topology. During resource locating in a multi-layer p2p system, the user can perform searches in different topologies as desired. The search efficiency can thus be improved as the routing and locating will not be constrained by the original routing rules.

  19. A hierarchical P2P overlay network for interest-based media contents lookup

    NASA Astrophysics Data System (ADS)

    Lee, HyunRyong; Kim, JongWon

    2006-10-01

    We propose a P2P (peer-to-peer) overlay architecture, called IGN (interest grouping network), for contents lookup in the DHC (digital home community), which aims to provide a formalized home-network-extended construction of current P2P file sharing community. The IGN utilizes the Chord and de Bruijn graph for its hierarchical overlay network construction. By combining two schemes and by inheriting its features, the IGN efficiently supports contents lookup. More specifically, by introducing metadata-based lookup keyword, the IGN offers detailed contents lookup that can reflect the user interests. Moreover, the IGN tries to reflect home network environments of DHC by utilizing HG (home gateway) of each home network as a participating node of the IGN. Through experimental and analysis results, we show that the IGN is more efficient than Chord, a well-known DHT (distributed hash table)-based lookup protocol.

  20. The STF2p Hydrophilin from Saccharomyces cerevisiae Is Required for Dehydration Stress Tolerance

    PubMed Central

    López-Martínez, Gema; Rodríguez-Porrata, Boris; Margalef-Català, Mar; Cordero-Otero, Ricardo

    2012-01-01

    The yeast Saccharomyces cerevisiae is able to overcome cell dehydration; cell metabolic activity is arrested during this period but restarts after rehydration. The yeast genes encoding hydrophilin proteins were characterised to determine their roles in the dehydration-resistant phenotype, and STF2p was found to be a hydrophilin that is essential for survival after the desiccation-rehydration process. Deletion of STF2 promotes the production of reactive oxygen species and apoptotic cell death during stress conditions, whereas the overexpression of STF2, whose gene product localises to the cytoplasm, results in a reduction in ROS production upon oxidative stress as the result of the antioxidant capacity of the STF2p protein. PMID:22442684

  1. Hemi bonds and noncovalent interactions in the cational systems (XH2P: SHY)+

    NASA Astrophysics Data System (ADS)

    Li, Xiang; Li, An Yong

    2016-08-01

    Quantum chemistry ab initio MP2 and CCSD calculations were performed to investigate the P⋯S hemi bonds and noncovalent interactions in the radical cational systems (H3P:SH2)+, (FH2P:SH2)+ and (H3P:SHF)+. The hydride dimer (H3P:SH2)+ has a P⋯S hemi bonding structure and a H-bonding structure, (FH2P:SH2)+ has two hemi bonding structures and a proton-transferred H-bonding structure, (H3P:SHF)+ has two hemi bonding structures and three noncovalent structures. It is remarkable that these hemi bonds also have characters of pnicogen and chalcogen bonds. The binding energy, stability and bonding nature of the hemi bonds were presented.

  2. A study of the physical properties of single crystalline Fe5B2P

    NASA Astrophysics Data System (ADS)

    Lamichhane, Tej N.; Taufour, Valentin; Thimmaiah, Srinivasa; Parker, David S.; Bud'ko, Sergey L.; Canfield, Paul C.

    2016-03-01

    Single crystals of Fe5B2P were grown by self-flux growth technique. Structural and electrical and magnetic anisotropic properties are studied. The Curie temperature of Fe5B2P is determined to be 655±2 K. The saturation magnetization is determined to be 1.72 μB/Fe at 2 K. The temperature variation of the anisotropy constant K1 is determined for the first time, reaching ∼ 0.50 MJ/m3 at 2 K, and it is comparable to that of hard ferrites. The saturation magnetization is found to be larger than the hard ferrites. The first principle calculations of saturation magnetization and anisotropy constant are found to be consistent with the experimental results.

  3. n-p Short-Range Correlations from (p,2p + n) Measurements

    NASA Astrophysics Data System (ADS)

    Watson, J. W.; Tang, A.; Alster, J.; Malki, A.; Navon, I.; Piasetzky, E.; Heppelmann, S.; Leksanov, A.; Minina, E.; Ogawa, A.; Zhalov, D.; Barton, D.; Carroll, A.; Makdisi, Y.; Nicholson, H.; Arsyan, G.; Baturin, V.; Bukhtoyarova, N.; Schetkovsky, A.; Averichev, Y.; Panebratsev, Yu.; Shimanskiy, S.; Kawabata, T.; Yoshida, H.

    2001-10-01

    Recently, a new technique was reported(Aclander et al., Phys. Lett B453, 211 (1999).) for studying N-N short-range correlations in nuclei, with the triple-coincidence (p,2p + n) reaction. We report here results from applying this technique to new data for ^12C(p,2p + n) at 5.9, 8.0 and 9.0 GeV/c beam momenta. For detected neutrons with pn > 0.22 GeV/c (the Fermi momentum for ^12C), the geometrical correlation signal for n-p pairs with nearly equal and opposite momenta is very striking. For neutrons with pn < 0.22 GeV/c, the geometrical correlation is absent.

  4. n-p Short-Range Correlations from (p,2p+n) Measurements

    NASA Astrophysics Data System (ADS)

    Tang, A.; Watson, J. W.; Aclander, J.; Alster, J.; Asryan, G.; Averichev, Y.; Barton, D.; Baturin, V.; Bukhtoyarova, N.; Carroll, A.; Gushue, S.; Heppelmann, S.; Leksanov, A.; Makdisi, Y.; Malki, A.; Minina, E.; Navon, I.; Nicholson, H.; Ogawa, A.; Panebratsev, Yu.; Piasetzky, E.; Schetkovsky, A.; Shimanskiy, S.; Zhalov, D.

    2003-01-01

    We studied the 12C(p,2p+n) reaction at beam momenta of 5.9, 8.0, and 9.0 GeV/c. For quasielastic (p,2p) events pf, the momentum of the knocked-out proton before the reaction, was compared (event by event) with pn, the coincident neutron momentum. For |pn|>kF=0.220 GeV/c (the Fermi momentum) a strong back-to-back directional correlation between pf and pn was observed, indicative of short-range n-p correlations. From pn and pf we constructed the distributions of c.m. and relative motion in the longitudinal direction for correlated pairs. We also determined that 49±13% of events with |pf|>kF had directionally correlated neutrons with |pn|>kF.

  5. Tatton-Brown-Rahman syndrome due to 2p23 microdeletion.

    PubMed

    Okamoto, Nobuhiko; Toribe, Yasuhisa; Shimojima, Keiko; Yamamoto, Toshiyuki

    2016-05-01

    Tatton-Brown-Rahman syndrome is a new overgrowth syndrome due to DNMT3A (DNA cytosine 5 methyltransferase 3A) mutations. Mutation carriers show a distinctive facial appearance, intellectual disability, and increased height. We report a patient with overgrowth who showed submicroscopic deletion of chromosome 2p23 including DNMT3A. The deletion was detected by array-CGH. He showed moderate ID and distinctive facial gestalt. His clinical features were consistent with those of Tatton-Brown-Rahman syndrome. We suggest that 2p23 microdeletion including DNMT3A may cause similar symptoms in patients with DNMT3A mutations and should be considered in patients with overgrowth. © 2016 Wiley Periodicals, Inc. PMID:26866722

  6. Photoionization from the 5p {sup 2}P{sub 3/2} state of rubidium

    SciTech Connect

    Nadeem, Ali; Haq, S. U.

    2011-06-15

    We report two-step photoionization studies from the 5p {sup 2}P{sub 3/2} excited state of rubidium using two dye lasers simultaneously pumped by a common Nd:YAG laser in conjunction with a thermionic diode ion detector. The photoionization cross section at the first ionization threshold is measured as 18.8 {+-} 3 Mb and at excess energies of 0.013, 0.106, 0.229, and 0.329 eV is measured as 15, 13.6, 12.6, and 12.5 Mb, respectively. The measured value of the photoionization cross section at the threshold is used to calibrate the oscillator strengths of the 5p {sup 2}P{sub 3/2}{yields}nd {sup 2}D{sub 5/2} (22 {<=}n{<=} 52) Rydberg transitions.

  7. n-p short-range correlations from (p,2p+n) measurements.

    PubMed

    Tang, A; Watson, J W; Aclander, J; Alster, J; Asryan, G; Averichev, Y; Barton, D; Baturin, V; Bukhtoyarova, N; Carroll, A; Gushue, S; Heppelmann, S; Leksanov, A; Makdisi, Y; Malki, A; Minina, E; Navon, I; Nicholson, H; Ogawa, A; Panebratsev, Yu; Piasetzky, E; Schetkovsky, A; Shimanskiy, S; Zhalov, D

    2003-01-31

    We studied the 12C(p,2p+n) reaction at beam momenta of 5.9, 8.0, and 9.0 GeV/c. For quasielastic (p,2p) events p(f), the momentum of the knocked-out proton before the reaction, was compared (event by event) with p(n), the coincident neutron momentum. For |p(n)|>k(F)=0.220 GeV/c (the Fermi momentum) a strong back-to-back directional correlation between p(f) and p(n) was observed, indicative of short-range n-p correlations. From p(n) and p(f) we constructed the distributions of c.m. and relative motion in the longitudinal direction for correlated pairs. We also determined that 49+/-13% of events with |p(f)|>k(F) had directionally correlated neutrons with |p(n)|>k(F). PMID:12570411

  8. Collision-induced decay of metastable baby Skyrmions

    SciTech Connect

    Dwyer, Daniel A.; Rajagopal, Krishna

    2000-11-15

    Many extensions of the standard model predict heavy metastable particles which may be modeled as solitons (Skyrmions of the Higgs field), relating their particle number to a winding number. Previous work has shown that the electroweak interactions admit processes in which these solitons decay, violating the standard model baryon number. We motivate the hypothesis that baryon-number-violating decay is a generic outcome of collisions between these heavy particles. We do so by exploring a (2+1)-dimensional theory which also possesses metastable Skyrmions. We use relaxation techniques to determine the size, shape, and energy of static solitons in their ground state. These solitons could decay by quantum-mechanical tunneling. Classically, they are metastable: only a finite excitation energy is required to induce their decay. We attempt to induce soliton decay in a classical simulation by colliding pairs of solitons. We analyze the collision of solitons with varying inherent stabilities and varying incident velocities and orientations. Our results suggest that winding-number violating decay is a generic outcome of collisions. All that is required is sufficient (not necessarily very large) incident velocity; no fine-tuning of initial conditions is required.

  9. Reliable measurement of the Li-like {sub 22}{sup 48}Ti 1s2s2p {sup 4}P{sub 5/2}{sup o} level lifetime by beam-foil and beam-two-foil experiments

    SciTech Connect

    Nandi, T.; Ahmad, Nissar; Wani, A. A.; Marketos, P.

    2006-03-15

    We have determined the lifetime of the Li-like {sub 22}{sup 48}Ti 1s2s2p {sup 4}P{sub 5/2}{sup o} level (210.5{+-}13.5 ps) using data from its x-ray decay channel through beam single- and two-foil experiments, coupled to a multicomponent iterative growth and decay analysis. Theoretical lifetime estimates for this zero-nuclear-spin ion lies within the uncertainty range of our experimental results, indicating that blending contributions to this level from the He-like 1s2p {sup 3}P{sub 2}{sup o} and 1s2s {sup 3}S{sub 1} levels are eliminated within the current approach. A previously reported discrepancy between experimental and theoretical 1s2s2p {sup 4}P{sub 5/2}{sup o} level lifetimes in {sub 23}{sup 51}V may, as a result, be attributed to hyperfine quenching.

  10. α and 2p2n emission in fast neutron-induced reactions on Ni60

    DOE PAGESBeta

    Fotiades, N.; Devlin, M.; Haight, R. C.; Nelson, R. O.; Kunieda, S.; Kawano, T.

    2015-06-19

    The cross sections for populating the residual nucleus in the reaction AZX(n,x)A-4Z-2Y exhibit peaks as a function of incident neutron energy corresponding to the (n,n'α) reaction and, at higher energy, to the (n,2p3n) reaction. In addition, the relative magnitudes of these peaks vary with the Z of the target nucleus.

  11. Spin- and angle-resolved spectroscopy of S 2p photoionization in the hydrogen sulfide molecule

    SciTech Connect

    Turri, G.; Snell, G.; Canton, S.E.; Bilodeau, R.C.; Langer, B.; Martins, M.; Kukk, E.; Cherepkov, N.; Bozek, J.D.; Kilcoyne, A.L.; Berrah, N.

    2004-08-01

    Angle- and spin-resolved photoelectron spectroscopy with circularly and linearly polarized synchrotron radiation were used to study the electronic structure of the hydrogen sulfide molecule. A strong effect of the molecular environment appears in the spin-resolved measurements and, although less clearly, in the angular distribution of the sulfur 2p photoelectrons. The anisotropy and spin parameters of the three main spectral components have been obtained. The validity of simple atomic models in explaining the results is discussed.

  12. Fragmentation of methyl chloride photoexcited near Cl (2p) by mass spectrometry

    NASA Astrophysics Data System (ADS)

    Thissen, Roland; Simon, Marc; Hubin-Franskin, M.-J.

    1994-11-01

    The evolution of the fragmentation pathways of the methylchloride around the Cl 2p edge has been studied by use of charge separation mass spectrometry. Some fragmentation patterns are discussed in the frame of rapid fragmentation of the neutral and dissociation pathways characteristic of singly or multiply charged species. The correlation of the evolution of the charge separation spectra with the initial excitation process is used to give a definitive attribution to the pre-edge features present in the absorption spectrum.

  13. Production and Identification of Wheat-Agropyron cristatum 2P Translocation Lines.

    PubMed

    Li, Huanhuan; Lv, Mingjie; Song, Liqiang; Zhang, Jinpeng; Gao, Ainong; Li, Lihui; Liu, Weihua

    2016-01-01

    Agropyron cristatum (L.) Gaertn. (2n = 28, PPPP), a wild relative of common wheat, possesses many potentially valuable traits that can be transferred to common wheat through breeding programs. The wheat-A. cristatum disomic addition and translocation lines can be used as bridge materials to introduce alien chromosomal segments to wheat. Wheat-A. cristatum 2P disomic addition line II-9-3 was highly resistant to powdery mildew and leaf rust, which was reported in our previous study. However, some translocation lines induced from II-9-3 have not been reported. In this study, some translocation lines were induced from II-9-3 by 60Co-γ irradiation and gametocidal chromosome 2C and then identified by cytological methods. Forty-nine wheat-A. cristatum translocation lines were obtained and various translcoation types were identified by GISH (genomic in situ hybridization), such as whole-arm, segmental and intercalary translocations. Dual-color FISH (fluorescent in situ hybridization) was applied to identify the wheat chromosomes involved in the translocations, and the results showed that A. cristatum 2P chromosome segments were translocated to the different wheat chromosomes, including 1A, 2A, 3A, 4A, 5A, 6A, 7A, 3B, 5B, 7B, 1D, 4D and 6D. Many different types of wheat-A. cristatum alien translocation lines would be valuable for not only identifying and cloning A. cristatum 2P-related genes and understanding the genetics and breeding effects of the translocation between A. cristatum chromosome 2P and wheat chromosomes, but also providing new germplasm resources for the wheat genetic improvement. PMID:26731742

  14. Production and Identification of Wheat-Agropyron cristatum 2P Translocation Lines

    PubMed Central

    Li, Huanhuan; Lv, Mingjie; Song, Liqiang; Zhang, Jinpeng; Gao, Ainong; Li, Lihui; Liu, Weihua

    2016-01-01

    Agropyron cristatum (L.) Gaertn. (2n = 28, PPPP), a wild relative of common wheat, possesses many potentially valuable traits that can be transferred to common wheat through breeding programs. The wheat-A. cristatum disomic addition and translocation lines can be used as bridge materials to introduce alien chromosomal segments to wheat. Wheat-A. cristatum 2P disomic addition line II-9-3 was highly resistant to powdery mildew and leaf rust, which was reported in our previous study. However, some translocation lines induced from II-9-3 have not been reported. In this study, some translocation lines were induced from II-9-3 by 60Co-γ irradiation and gametocidal chromosome 2C and then identified by cytological methods. Forty-nine wheat-A. cristatum translocation lines were obtained and various translcoation types were identified by GISH (genomic in situ hybridization), such as whole-arm, segmental and intercalary translocations. Dual-color FISH (fluorescent in situ hybridization) was applied to identify the wheat chromosomes involved in the translocations, and the results showed that A. cristatum 2P chromosome segments were translocated to the different wheat chromosomes, including 1A, 2A, 3A, 4A, 5A, 6A, 7A, 3B, 5B, 7B, 1D, 4D and 6D. Many different types of wheat-A. cristatum alien translocation lines would be valuable for not only identifying and cloning A. cristatum 2P-related genes and understanding the genetics and breeding effects of the translocation between A. cristatum chromosome 2P and wheat chromosomes, but also providing new germplasm resources for the wheat genetic improvement. PMID:26731742

  15. 7 CFR 51.898 - Decay.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 2 2011-01-01 2011-01-01 false Decay. 51.898 Section 51.898 Agriculture Regulations... Standards for Grades of Table Grapes (European or Vinifera Type) 1 Definitions § 51.898 Decay. Decay means.... Slight surface development of green mold (Cladosporium) shall not be considered decay....

  16. HopRec: Hop-Based Recommendation Ability Enhanced Reputation Ranking in P2P Networks

    NASA Astrophysics Data System (ADS)

    Wang, Yufeng; Nakao, Akihiro; Ma, Jianhua

    As a concept stemmed from social field, we argued that, in P2P networks, peers' recommendation behaviors and functional behaviors should be explicitly separated, thus we propose the HopRec scheme which uses hop-based recommendation ability to improve the accuracy of reputation ranking in P2P networks. Our contributions lie in the following aspects: firstly, we adopt the simple but effective idea to infer peer's recommendation ability (RA): the farer away that peer is from the initial malicious seeds, the higher RA that peer should have; Then, the computation of reputation rankings appropriately reflects peer's different RA. The simulation results show that, in comparison with Eigentrust-like algorithms, HopRec can be robust to sybils and front peers attacks, and achieve significant performance improvement. Moreover, we compare HopRec with two related schemes, Poisonedwater and CredibleRank, and found that: in hospitable P2P environment, HopRec can obtain better performance than Poisonedwater, and can achieve the comparable performance as CredibleRank, with less computation overhead then CredibleRank. Finally, we also show that, if the initial good and malicious seeds could be selected based on peers' degrees, then HopRec and CredibleRank can achieve perfect performance.

  17. Elastic, magnetic and electronic properties of iridium phosphide Ir2P

    DOE PAGESBeta

    Wang, Pei; Wang, Yonggang; Wang, Liping; Zhang, Xinyu; Yu, Xiaohui; Zhu, Jinlong; Wang, Shanmin; Qin, Jiaqian; Leinenweber, Kurt; Chen, Haihua; et al

    2016-02-24

    Cubic (space group: Fm3¯m) iridium phosphide, Ir2P, has been synthesized at high pressure and high temperature. Angle-dispersive synchrotron X-ray diffraction measurements on Ir2P powder using a diamond-anvil cell at room temperature and high pressures (up to 40.6 GPa) yielded a bulk modulus of B0 = 306(6) GPa and its pressure derivative B0'= 6.4(5). Such a high bulk modulus attributed to the short and strongly covalent Ir-P bonds as revealed by first – principles calculations and three-dimensionally distributed [IrP4] tetrahedron network. Indentation testing on a well–sintered polycrystalline sample yielded the hardness of 11.8(4) GPa. Relatively low shear modulus of ~64 GPamore » from theoretical calculations suggests a complicated overall bonding in Ir2P with metallic, ionic, and covalent characteristics. Additionally, a spin glass behavior is indicated by magnetic susceptibility measurements.« less

  18. A novel susceptibility locus at 2p24 for generalised epilepsy with febrile seizures plus.

    PubMed

    Audenaert, D; Claes, L; Claeys, K G; Deprez, L; Van Dyck, T; Goossens, D; Del-Favero, J; Van Paesschen, W; Van Broeckhoven, C; De Jonghe, P

    2005-12-01

    Generalised epilepsy with febrile seizures plus (GEFS+) is a clinically and genetically heterogeneous epilepsy syndrome. Using positional cloning strategies, mutations in SCN1B, SCN1A, and GABRG2 have been identified as genetic causes of GEFS+. In the present study, we describe a large four generation family with GEFS+ in which we performed a 10 cM density genome-wide scan. We obtained conclusive evidence for a novel GEFS+ locus on chromosome 2p24 with a maximum two point logarithm of the odds (LOD) score of 4.22 for marker D2S305 at zero recombination. Fine mapping and haplotype segregation analysis in this family delineated a candidate region of 3.24 cM, corresponding to a physical distance of 4.2 Mb. Linkage to 2p24 was confirmed (p = 0.007) in a collection of 50 nuclear and multiplex families with febrile seizures and epilepsy. Transmission disequilibrium testing and association studies provided further evidence (p < 0.05) that 2p24 is a susceptibility locus for febrile seizures and epilepsy. Furthermore, we could reduce the candidate region to a 2.14 cM interval, localised between D2S1360 and D2S2342, based upon an ancestral haplotype. Identification of the disease gene at this locus will contribute to a better understanding of the complex genetic aetiology of febrile seizures and epilepsy. PMID:15827091

  19. Low Q2 Measurement of g2p and the LT Spin Polarizability

    SciTech Connect

    Karl Slifer

    2009-07-01

    JLab has been at the forefront of a program to measure the nucleon spin-dependent structure functions over a wide kinematic range, and data of unprecedented quality has been extracted in all three experimental halls. Moments of these quantities have proven to be powerful tools to test QCD sum rules and provide benchmark tests of Lattice QCD and Chiral Perturbation Theory. Precision measurements of $g_{1,2}^n$ and $g_1^p$ have been performed as part of the highly successful `extended GDH program', but data on the $g_2^p$ structure function remain scarce. We discuss here JLab experiment E08-027, which will measure quantity $g_2^p$ in the resonance region at low $Q^2$. These data will be used to test the Burkhardt-Cottingham sum rule and to extract the higher moments $\\delta_{LT}^p(Q^2)$ and $\\overline{d}_2^p(Q^2)$. Data in the $Q^2$ range $0.02

  20. Elastic, magnetic and electronic properties of iridium phosphide Ir2P

    DOE PAGESBeta

    Wang, Pei; Wang, Yonggang; Wang, Liping; Zhang, Xinyu; Yu, Xiaohui; Zhu, Jinlong; Wang, Shanmin; Qin, Jiaqian; Leinenweber, Kurt; Chen, Haihua; et al

    2016-02-24

    Cubic (space group: Fm3¯m) iridium phosphide, Ir2P, has been synthesized at high pressure and high temperature. Angle-dispersive synchrotron X-ray diffraction measurements on Ir2P powder using a diamond-anvil cell at room temperature and high pressures (up to 40.6 GPa) yielded a bulk modulus of B0 = 306(6) GPa and its pressure derivative B0' = 6.4(5). Such a high bulk modulus attributed to the short and strongly covalent Ir-P bonds as revealed by first – principles calculations and three-dimensionally distributed [IrP4] tetrahedron network. Indentation testing on a well–sintered polycrystalline sample yielded the hardness of 11.8(4) GPa. Relatively low shear modulus of ~64more » GPa from theoretical calculations suggests a complicated overall bonding in Ir2P with metallic, ionic, and covalent characteristics. Additionally, a spin glass behavior is indicated by magnetic susceptibility measurements.« less

  1. Elastic, magnetic and electronic properties of iridium phosphide Ir2P

    NASA Astrophysics Data System (ADS)

    Wang, Pei; Wang, Yonggang; Wang, Liping; Zhang, Xinyu; Yu, Xiaohui; Zhu, Jinlong; Wang, Shanmin; Qin, Jiaqian; Leinenweber, Kurt; Chen, Haihua; He, Duanwei; Zhao, Yusheng

    2016-02-01

    Cubic (space group: Fmm) iridium phosphide, Ir2P, has been synthesized at high pressure and high temperature. Angle-dispersive synchrotron X-ray diffraction measurements on Ir2P powder using a diamond-anvil cell at room temperature and high pressures (up to 40.6 GPa) yielded a bulk modulus of B0 = 306(6) GPa and its pressure derivative B0‧ = 6.4(5). Such a high bulk modulus attributed to the short and strongly covalent Ir-P bonds as revealed by first - principles calculations and three-dimensionally distributed [IrP4] tetrahedron network. Indentation testing on a well-sintered polycrystalline sample yielded the hardness of 11.8(4) GPa. Relatively low shear modulus of ~64 GPa from theoretical calculations suggests a complicated overall bonding in Ir2P with metallic, ionic, and covalent characteristics. In addition, a spin glass behavior is indicated by magnetic susceptibility measurements.

  2. Elastic, magnetic and electronic properties of iridium phosphide Ir2P

    PubMed Central

    Wang, Pei; Wang, Yonggang; Wang, Liping; Zhang, Xinyu; Yu, Xiaohui; Zhu, Jinlong; Wang, Shanmin; Qin, Jiaqian; Leinenweber, Kurt; Chen, Haihua; He, Duanwei; Zhao, Yusheng

    2016-01-01

    Cubic (space group: Fmm) iridium phosphide, Ir2P, has been synthesized at high pressure and high temperature. Angle-dispersive synchrotron X-ray diffraction measurements on Ir2P powder using a diamond-anvil cell at room temperature and high pressures (up to 40.6 GPa) yielded a bulk modulus of B0 = 306(6) GPa and its pressure derivative B0′ = 6.4(5). Such a high bulk modulus attributed to the short and strongly covalent Ir-P bonds as revealed by first – principles calculations and three-dimensionally distributed [IrP4] tetrahedron network. Indentation testing on a well–sintered polycrystalline sample yielded the hardness of 11.8(4) GPa. Relatively low shear modulus of ~64 GPa from theoretical calculations suggests a complicated overall bonding in Ir2P with metallic, ionic, and covalent characteristics. In addition, a spin glass behavior is indicated by magnetic susceptibility measurements. PMID:26905444

  3. 8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction

    PubMed Central

    Jacobsson, Jimmy; Nilsson, Jesper R.; Min, Jaeki; Iconaru, Luigi; Guy, R. Kiplin; Kriwacki, Richard W.; Andréasson, Joakim; Grøtli, Morten

    2015-01-01

    Small molecule nonpeptidic mimics of α-helices are widely recognised as protein-protein interaction (PPIs) inhibitors. Protein-protein interactions mediate virtually all important regulatory pathways in a cell, and the ability to control and modulate PPIs is therefore of great significance to basic biology, where controlled disruption of protein networks is key to understanding network connectivity and function. We have designed and synthesised two series of 2,6,9-substituted 8-triazolylpurines as α-helix mimetics. The first series was designed based on low energy conformations but did not display any biological activity in a biochemical fluorescence polarisation assay targeting MDM2/p53. Although solution NMR conformation studies demonstrated that such molecules could mimic the topography of an α-helix, docking studies indicated that the same compounds were not optimal as inhibitors for the MDM2/p53 interaction. A new series of 8-triazolylpurines was designed based on a combination of docking studies and analysis of recently published inhibitors. The best compound displayed low micromolar inhibitory activity towards MDM2/p53 in a biochemical fluorescence polarisation assay. In order to evaluate the applicability of these compounds as biologically active and intrinsically fluorescent probes, their absorption/emission properties were measured. The compounds display fluorescent properties with quantum yields up to 50%. PMID:25942498

  4. Duplication 2p25 in a child with clinical features of CHARGE syndrome.

    PubMed

    Sperry, Ethan D; Schuette, Jane L; van Ravenswaaij-Arts, Conny M A; Green, Glenn E; Martin, Donna M

    2016-05-01

    CHARGE syndrome is a dominant disorder characterized by ocular colobomata, heart defects, choanal atresia, retardation of growth and development, genital hypoplasia, and ear abnormalities including deafness and vestibular disorders. The majority of individuals with CHARGE have pathogenic variants in the gene encoding CHD7, a chromatin remodeling protein. Here, we present a 15-year-old girl with clinical features of CHARGE syndrome and a de novo 6.5 Mb gain of genomic material at 2p25.3-p25.2. The duplicated region contained 24 genes, including the early and broadly expressed transcription factor gene SOX11. Analysis of 28 other patients with CHARGE showed no SOX11 copy number changes or pathogenic sequence variants. To our knowledge, this child's chromosomal abnormality is unique and represents the first co-occurrence of duplication 2p25 and clinical features of CHARGE syndrome. We compare our patient's phenotype to ten previously published patients with isolated terminal duplication 2p, and elaborate on the clinical diagnosis of CHARGE in the context of atypical genetic findings. © 2016 Wiley Periodicals, Inc. PMID:26850571

  5. Elastic, magnetic and electronic properties of iridium phosphide Ir2P.

    PubMed

    Wang, Pei; Wang, Yonggang; Wang, Liping; Zhang, Xinyu; Yu, Xiaohui; Zhu, Jinlong; Wang, Shanmin; Qin, Jiaqian; Leinenweber, Kurt; Chen, Haihua; He, Duanwei; Zhao, Yusheng

    2016-01-01

    Cubic (space group: Fmm) iridium phosphide, Ir2P, has been synthesized at high pressure and high temperature. Angle-dispersive synchrotron X-ray diffraction measurements on Ir2P powder using a diamond-anvil cell at room temperature and high pressures (up to 40.6 GPa) yielded a bulk modulus of B0 = 306(6) GPa and its pressure derivative B0' = 6.4(5). Such a high bulk modulus attributed to the short and strongly covalent Ir-P bonds as revealed by first - principles calculations and three-dimensionally distributed [IrP4] tetrahedron network. Indentation testing on a well-sintered polycrystalline sample yielded the hardness of 11.8(4) GPa. Relatively low shear modulus of ~64 GPa from theoretical calculations suggests a complicated overall bonding in Ir2P with metallic, ionic, and covalent characteristics. In addition, a spin glass behavior is indicated by magnetic susceptibility measurements. PMID:26905444

  6. Autoionization study of the Argon 2p satellites excited near the argon 2s threshold

    SciTech Connect

    Wang, H.; Glans, P.; Hemmers, O.

    1997-04-01

    The dynamics of near-threshold photoionization is a complex phenomenon in which the many-electron character of the wavefunctions plays an important role. According to generalized time-independent resonant scattering theory, the transition matrix element from an initial state to a final state is the summation of the amplitudes of direct photoionization and an indirect term in which intermediate states are involved and the resonant behavior is embedded. Studies of the interference effects of intermediate states have been explored in the cases where the direct term is negligible. In the present work, electron time-of-flight spectra of the Ar 2p satellites were measured at two angles (magic and 0{degrees}) in the dipole plane with the exciting photon energy tuned in the vicinity of the Ar 2s threshold. For excitation far below or above the 2s threshold, the 2p satellites spectrum is dominated by 3p to np shakeup contributions upon the ionization of a 2p electron.

  7. The Sla2p talin domain plays a role in endocytosis in Saccharomyces cerevisiae.

    PubMed Central

    Baggett, Jennifer J; D'Aquino, Katharine E; Wendland, Beverly

    2003-01-01

    Clathrin-binding adaptors play critical roles for endocytosis in multicellular organisms, but their roles in budding yeast have remained unclear. To address this question, we created a quadruple mutant yeast strain lacking the genes encoding the candidate clathrin adaptors Yap1801p, Yap1802p, and Ent2p and containing a truncated version of Ent1p, Ent1DeltaCBMp, missing its clathrin-binding motif. This strain was viable and competent for endocytosis, suggesting the existence of other redundant adaptor-like factors. To identify these factors, we mutagenized the quadruple clathrin adaptor mutant strain and selected cells that were viable in the presence of full-length Ent1p, but inviable with only Ent1DeltaCBMp; these strains were named Rcb (requires clathrin binding). One mutant strain, rcb432, contained a mutation in SLA2 that resulted in lower levels of a truncated protein lacking the F-actin binding talin homology domain. Analyses of this sla2 mutant showed that the talin homology domain is required for endocytosis at elevated temperature, that SLA2 exhibits genetic interactions with both ENT1 and ENT2, and that the clathrin adaptors and Sla2p together regulate the actin cytoskeleton and revealed conditions under which Yap1801p and Yap1802p contribute to viability. Together, our data support the view that Sla2p is an adaptor that links actin to clathrin and endocytosis. PMID:14704157

  8. Post-collision-interaction distortion of low-energy photoelectron spectra associated with double Auger decay

    SciTech Connect

    Gerchikov, L.; Sheinerman, S.

    2011-08-15

    Atomic inner-shell photoionization followed by double Auger decay is investigated. The focus of our study is the effect of post-collision interaction (PCI) on the photoelectron energy distribution. A semi-classical approach is employed to describe the PCI distortion of the photoelectron line shapes associated with both direct and cascade double Auger decays. This approach is shown to be valid at low photoelectron energies, whereas for large incident photon energies it reduces to the eikonal approximation. The theory is applied to the case of Ar 2p photoionization spectra and good agreement with available experimental data is achieved.

  9. Photoelectron recapture and reemission process associated with double Auger decay in Ar

    NASA Astrophysics Data System (ADS)

    Hikosaka, Y.; Mashiko, R.; Odagiri, T.; Adachi, J.; Tanaka, H.; Kosuge, T.; Ito, K.

    2016-06-01

    Multielectron coincidence spectroscopy has been performed for Ar at a photon energy of only 0.2 eV above the 2 p1 /2 threshold. It is revealed that a postcollision interaction induced by double Auger decay leads to photoelectron recapture, followed by reemission of the captured electron, where the recapture of the slow photoelectron forms the A r2 + Rydberg-excited states which subsequently undergo autoionization. The energy correlation of the emitted electrons discloses that both direct and cascade paths in the double Auger decay contribute to the photoelectron recapture.

  10. Comparative Analysis of Double Auger Decay and Two-Step Shake-Off Resulting from the Relaxation of Core Excited Neon

    NASA Astrophysics Data System (ADS)

    Jones, M. P.; Schoffler, M.; Jahnke, T.; Kreidi, K.; Titze, J.; Dorner, R.; Stuck, C.; Belkacem, A.; Weber, Th.; Landers, A. L.

    2011-05-01

    We have conducted a COLTRIMS experiment at the ALS-LBNL to investigate the core excitation of neon: Ne + γ --> Ne(1s2s2 2p6 3 p) . The subsequent electronic relaxation produced among others, the Ne2+ charge state. An analysis of this channel revealed mechanisms that include Double Auger (DA) decay as well as a two-step shake-off process involving the 3 p electron. In addition, we have studied the energy sharing and angular correlation that takes place between the continuum electrons. These detailed measurements further our understanding of the sequential nature of PCI and the characterization of the DA process. Lastly, we will demonstrate how the series of line energies associated with the shake process can be exploited to produce an extremely sensitive method for calibrating a COLTRIMS spectrometer. We have conducted a COLTRIMS experiment at the ALS-LBNL to investigate the core excitation of neon: Ne + γ --> Ne(1s2s2 2p6 3 p) . The subsequent electronic relaxation produced among others, the Ne2+ charge state. An analysis of this channel revealed mechanisms that include Double Auger (DA) decay as well as a two-step shake-off process involving the 3 p electron. In addition, we have studied the energy sharing and angular correlation that takes place between the continuum electrons. These detailed measurements further our understanding of the sequential nature of PCI and the characterization of the DA process. Lastly, we will demonstrate how the series of line energies associated with the shake process can be exploited to produce an extremely sensitive method for calibrating a COLTRIMS spectrometer. Supported by AMOS Program, Office of BES, Division of Chemical Sciences, U.S. Dept. of Energy.

  11. Theoretical Studies of the Role of Vibrational Excitation on the Dynamics of the Hydrogen-Transfer Reaction of F(^2P) + HCl → FH + Cl({^2}P)

    NASA Astrophysics Data System (ADS)

    Ray, Sara E.; Vissers, Gé W. M.; McCoy, Anne B.

    2009-06-01

    Hydrogen-transfer reactions are probed through vibrational excitation of the HCl bond in the pre-reactive F\\cdotsHCl complex. Such open-shell species provide a challenge for quantum dynamical calculations due to the need to take into account multiple potential energy surfaces to accurately describe the system.A three-dimensional, fully-coupled potential energy surface has been constructed based on electronic energies calculated at the multireference configuration interaction+Davidson correction (MRCI+Q) level of theory with an aug-cc-pVnZ (n=2,3,4) basis. Spin orbit calculations have also been included. Here we present the results of time-dependent quantum wave packet calculations on the asymmetric hydrogen-transfer reaction of F(^2P) + HCl. In these calculations, the reaction is initiated by vibrationally exciting the HCl stretching motion in the pre-reactive F\\cdotsHCl complex. The wave packet is propagated on the coupled potential energy surfaces. Product state distributions were calculated for reactions initiated in the first three vibrationally excited states of HCl, v=1-3. M. P. Deskevich, M. Y. Hayes, K. Takahashi, R. T. Skodje, and D. J. Nesbitt J. Chem. Phys. 124 (22) 224303 (2006) M. P. Deskevich and D. J. Nesbitt private communication(2007)

  12. α -decay chains of recoiled superheavy nuclei: A theoretical study

    NASA Astrophysics Data System (ADS)

    Niyti, Sawhney, Gudveen; Sharma, Manoj K.; Gupta, Raj K.

    2015-05-01

    A systematic theoretical study of α -decay half-lives in the superheavy mass region of the periodic table of elements is carried out by extending the quantum-mechanical fragmentation theory based on the preformed cluster model (PCM) to include temperature (T ) dependence in its built-in preformation and penetration probabilities of decay fragments. Earlier, the α -decay chains of the isotopes of Z =115 were investigated by using the standard PCM for spontaneous decays, with"hot-optimum" orientation effects included, which required a constant scaling factor of 104 to approach the available experimental data. In the present approach of the PCM (T ≠0 ), the temperature effects are included via the recoil energy of the residual superheavy nucleus (SHN) left after x -neutron emission from the superheavy compound nucleus. The important result is that the α -decay half-lives calculated by the PCM (T ≠0 ) match the experimental data nearly exactly, without using any scaling factor of the type used in the PCM. Note that the PCM (T ≠0 ) is an equivalent of the dynamical cluster-decay model for heavy-ion collisions at angular momentum ℓ =0 . The only parameter of model is the neck-length parameter Δ R , which for the calculated half-lives of α -decay chains of various isotopes of Z =113 to 118 nuclei formed in "hot-fusion" reactions is found to be nearly constant, i.e., Δ R ≈0.95 ±0.05 fm for all the α -decay chains studied. The use of recoiled residue nucleus as a secondary heavy-ion beam for nuclear reactions has also been suggested in the past.

  13. Reactions of State-Selected Atomic Oxygen Ions O(+)((4)S, (2)D, (2)P) with Methane.

    PubMed

    Cunha de Miranda, Barbara; Romanzin, Claire; Chefdeville, Simon; Vuitton, Véronique; Žabka, Jan; Polášek, Miroslav; Alcaraz, Christian

    2015-06-11

    An experimental study has been carried out on the reactions of state selected O(+)((4)S, (2)D, (2)P) ions with methane with the aims of characterizing the effects of both the parent ion internal energy and collision energy on the reaction dynamics and determining the fate of oxygen species in complex media, in particular the Titan ionosphere. Absolute cross sections and product velocity distributions have been determined for the reactions of (16)O(+) or (18)O(+) ions with CH4 or CD4 from thermal to 5 eV collision energies by using the guided ion beam (GIB) technique. Dissociative photoionization of O2 with vacuum ultraviolet (VUV) synchrotron radiation delivered by the DESIRS beamline at the SOLEIL storage ring and the threshold photoion photoelectron coincidence (TPEPICO) technique are used for the preparation of purely state-selected O(+)((4)S, (2)D, (2)P) ions. A complete inversion of the product branching ratio between CH4(+) and CH3(+) ions in favor of the latter is observed for excitation of O(+) ions from the (4)S ground state to either the (2)D or the (2)P metastable state. CH4(+) and CH3(+) ions, which are by far the major products for the reaction of ground state and excited states, are strongly backward scattered in the center of mass frame relative to O(+) parent ions. For the reaction of O(+)((4)S), CH3(+) production also rises with increasing collision energy but with much less efficiency than with O(+) excitation. We found that a mechanism of dissociative charge transfer, mediated by an initial charge transfer step, can account very well for all the observations, indicating that CH3(+) production is associated with the formation of H and O atoms (CH3(+) + H + O) rather than with OH formation by an hydride transfer process (CH3(+) + OH). Therefore, as the CH4(+) production by charge transfer is also associated with O atoms, the fate of oxygen species in these reactions is essentially the O production, except for the reaction of O(+)((4)S), which also

  14. Identification of novel small molecule modulators of K2P18.1 two-pore potassium channel

    PubMed Central

    Bruner, J. Kyle; Zou, Beiyan; Zhang, Hongkang; Zhang, Yixin; Schmidt, Katharina; Li, Min

    2014-01-01

    Two-pore domain potassium (K2P) channels are responsible for background potassium (K+) current, which is crucial for the maintenance of resting membrane potential. K2P18.1, also called TWIK-related spinal cord K+ channel (TRESK) or KCNK18, is thought to be a major contributor to background K+ currents, particularly in sensory neurons where it is abundantly expressed. Despite its critical role and potential therapeutic implication, pharmacological tools for probing K2P18.1 activity remain unavailable. Here, we report a high-throughput screen against a collection of bioactive compounds that yielded 26 inhibitors and 8 activators of K2P18.1 channel activity with more than 10-fold selectivity over the homologous channel K2P9.1. Among these modulators, the antihistamine loratadine inhibited K2P18.1 activity with IC50 of 0.49 ± 0.23 μM and is considerably more potent than existing K2P18.1 inhibitors. Importantly, the inhibition by loratadine remains equally efficacious upon potentiation of K2P18.1 by calcium signaling. Furthermore, the loratadine effect is dependent on transmembrane residues F145 and F352, providing orthogonal evidence that the inhibition is caused by a direct compound-channel interaction. This study reveals new pharmacological modulators of K2P18.1 activity useful in dissecting native K2P18.1 function. PMID:24972239

  15. Investigation on Thermal-Induced Decay of Fiber Bragg Grating

    NASA Astrophysics Data System (ADS)

    Zhang, Peng; Ding, Pinyi; Liu, Li

    2015-06-01

    A fiber Bragg grating (FBG), with advantages such as high anti-interference ability, a simple structure, and multiplexing, is widely used as a core component in numerous applications to monitor adverse environments of high temperature and air pressure. When FBGs are exposed to these extreme conditions, especially high temperature, performance decay may occur, bringing serious impact on the stability and reliability of the instruments. Therefore, it is necessary to make a detailed analysis on the mechanism of the thermal-induced decay of a FBG. One commonly used theory is proposed by Erdogn, which is based on a power function and aging curve method. However, these empirical equations are limited in application because only one single type of FBG can be analyzed this way. This paper focuses on the mechanism of a FBG, and presents a detailed analysis on the theory of the thermal-induced decay of a FBG using the electron dipole mode. Theoretical relationships between reflectivity and time or temperature were obtained, and a corresponding thermal-induced decay testing system was designed. The experimental and theoretical reflectivity decline under different temperatures of and are plotted, and the curves of reduction derived from the theoretical model fit the experimental data well. Thus, this model can be applied to predict the performance decay of FBGs at high temperature.

  16. Higgs Doublet Decay as the Origin of the Baryon Asymmetry.

    PubMed

    Hambye, Thomas; Teresi, Daniele

    2016-08-26

    We consider a question that curiously had not been properly considered thus far: in the standard seesaw model, what is the minimum value the mass of a right-handed (RH) neutrino must have for allowing successful leptogenesis via CP-violating decays? Answering this question requires us to take into account a number of thermal effects. We show that, for low RH neutrino masses, and thanks to these effects, leptogenesis turns out to proceed efficiently from the decay of the standard model scalar doublet components into a RH neutrino and a lepton. Such decays produce the asymmetry at low temperatures, slightly before sphaleron decoupling. If the RH neutrino has thermalized prior to producing the asymmetry, this mechanism turns out to lead to the bound m_{N}>2  GeV. If, instead, the RH neutrinos have not thermalized, leptogenesis from these decays is enhanced further and can be easily successful, even at lower scales. This Higgs-decay leptogenesis new mechanism works without requiring an interplay of flavor effects and/or cancellations of large Yukawa couplings in the neutrino mass matrix. Last but not least, such a scenario turns out to be testable, from direct production of the RH neutrino(s). PMID:27610845

  17. Unsolved problems in hadronic charm decay

    SciTech Connect

    Browder, T.E.

    1989-08-01

    This paper describes several outstanding problems in the study of hadronic decays of charmed mesons where further experimental work and theoretical understanding is needed. Four topics are stressed: double Cabibbo suppressed decays (DCSD) of D/sup +/ mesons, hadronic D/sub s/ decays, weak hadronic quasi-two-body decays to pairs of vector mesons, and penguin decays of D mesons. 24 refs., 10 figs., 5 tabs.

  18. Decay curve study in a standard electron capture decay

    SciTech Connect

    Nishimura, D.; Fukuda, M.; Kisamori, K.; Kuwada, Y.; Makisaka, K.; Matsumiya, R.; Matsuta, K.; Mihara, M.; Takagi, A.; Yokoyama, R.; Izumikawa, T.; Ohtsubo, T.; Suzuki, T.; Yamaguchi, T.

    2010-05-12

    We have searched for a time-modulated decay in a standard electron capture experiment for {sup 140}Pr, in order to confirm a report from GSI, where an oscillatory decay has been observed for hydrogen-like {sup 140}Pr and {sup 142}Pm ions in the cooler storage ring. {sup 140}Pr has been produced with the {sup 140}Ce(p, n) reaction by a pulsed proton beam accelerated from the Van de Graaff accelerator at Osaka University. Resultant time dependence of the K{sub a}lpha and K{sub b}eta X-ray intensities from the daughter shows no oscillatory behavior.

  19. Search for a strongly decaying neutral charmed pentaquark

    SciTech Connect

    Link, J.M.; Yager, P.M.; Anjos, J.C.; Bediaga, I.; Castromonte, C.; Machado, A.A.; Magnin, J.; Massafferri, A.; de Miranda, J.M.; Pepe, I.M.; Polycarpo, E.; dos Reis, A.C.; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sanchez-Hernandez, A.; Uribe, C.; Vazquez, F.; Agostino, L.; Cinquini, L.; Cumalat, J.P.; /Colorado U. /Fermilab /Frascati /Guanajuato U. /Illinois U., Urbana /Indiana U. /Korea U. /Kyungpook Natl. U. /INFN, Milan /Milan U. /North Carolina U. /Pavia U. /INFN, Pavia /Rio de Janeiro, Pont. U. Catol. /Puerto Rico U., Mayaguez /South Carolina U. /Tennessee U. /Vanderbilt U. /Wisconsin U., Madison

    2005-06-01

    We present a search for a charmed pentaquark decaying strongly to D{sup (*)}-p. Finding no evidence for such a state, we set limits on the cross section times branching ratio relative to D*{sup -} and D{sup -} under particular assumptions about the production mechanism.

  20. CP violation and suppressed $B_s$ decays at CDF

    SciTech Connect

    Lewis, J.D.; /Fermilab

    2011-12-01

    The study of heavy-quark decays continues to have wide interest as a possible avenue for the discovery of physics beyond the standard model. With data samples as large as 6 fb{sup -1}, the CDF collaboration is exploring new channels that will extend the reach of measurements in probing the CKM mechanism of CP violation. Several new measurements are presented.

  1. On the Time-Dependent Analysis of Gamow Decay

    ERIC Educational Resources Information Center

    Durr, Detlef; Grummt, Robert; Kolb, Martin

    2011-01-01

    Gamow's explanation of the exponential decay law uses complex "eigenvalues" and exponentially growing "eigenfunctions". This raises the question, how Gamow's description fits into the quantum mechanical description of nature, which is based on real eigenvalues and square integrable wavefunctions. Observing that the time evolution of any…

  2. The Long Decay Model of One-Dimensional Projectile Motion

    ERIC Educational Resources Information Center

    Lattery, Mark Joseph

    2008-01-01

    This article introduces a research study on student model formation and development in introductory mechanics. As a point of entry, I present a detailed analysis of the Long Decay Model of one-dimensional projectile motion. This model has been articulated by Galileo ("in De Motu") and by contemporary students. Implications for instruction are…

  3. Calculations of Cascade Decay Processes Using Rudimentary Probability Theory.

    ERIC Educational Resources Information Center

    Zivitz, Maury

    1979-01-01

    Presents a new derivation based on simple theorems of probability theory for the established system of equations describing successive decay transitions of quantum systems. It is indicated that this derivation that has a quantum-mechanical foundation might be more appealing to applied physicists than other derivations. (HM)

  4. Dissociative recombination of molecular ions in the He-Ne plasma. Partial rate constants of atoms formation in the 2 p 53d and 2 p 54d configurations

    NASA Astrophysics Data System (ADS)

    Ivanov, V. A.; Petrovskaya, A. S.; Skoblo, Yu. E.

    2016-02-01

    A spectroscopic study of population processes was carried out for states of the neon atom of the 2 p 53 d configuration in the discharge afterglow in helium with a small admixture of neon ([Ne]/[He] ≈ 10-5) at a pressure of 38 Torr. Based on the comparative analysis of time dependences of the spectral line intensities of the Ne I 2 p 53 d → 2 p 53 d and 2 p 54 d → 2 p 53 d transitions and ratio of ion densities [Ne 2 + ]/[HeNe+], it has been found that the formation of excited Ne(2 p 53 d) atoms in the afterglow caused by two dissociative recombination processes: HeNe+ + e → Ne(2 p 53 d) + Ne and Ne 2 + + e → Ne(2 p 53 d) + Ne. Distributions of population fluxes of the 2 p 53 d levels Γ _{3{d_t}}^{HeN{e^ + }} and Γ _{3{d_t}}^{Ne_2^ + }—were obtained for each of these processes.

  5. Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K[superscript +] Ion Channel

    SciTech Connect

    Brohawn, Stephen G.; del Mármol, Josefina; MacKinnon, Roderick

    2012-03-01

    TRAAK channels, members of the two-pore domain K{sup +} (potassium ion) channel family K2P, are expressed almost exclusively in the nervous system and control the resting membrane potential. Their gating is sensitive to polyunsaturated fatty acids, mechanical deformation of the membrane, and temperature changes. Physiologically, these channels appear to control the noxious input threshold for temperature and pressure sensitivity in dorsal root ganglia neurons. We present the crystal structure of human TRAAK at a resolution of 3.8 angstroms. The channel comprises two protomers, each containing two distinct pore domains, which create a two-fold symmetric K{sup +} channel. The extracellular surface features a helical cap, 35 angstroms tall, that creates a bifurcated pore entry way and accounts for the insensitivity of two-pore domain K{sup +} channels to inhibitory toxins. Two diagonally opposed gate-forming inner helices form membrane-interacting structures that may underlie this channel's sensitivity to chemical and mechanical properties of the cell membrane.

  6. Cdc50p plays a vital role in the ATPase reaction cycle of the putative aminophospholipid transporter Drs2p.

    PubMed

    Lenoir, Guillaume; Williamson, Patrick; Puts, Catheleyne F; Holthuis, Joost C M

    2009-07-01

    Members of the P(4) subfamily of P-type ATPases are believed to catalyze transport of phospholipids across cellular bilayers. However, most P-type ATPases pump small cations or metal ions, and atomic structures revealed a transport mechanism that is conserved throughout the family. Hence, a challenging problem is to understand how this mechanism is adapted in P(4)-ATPases to flip phospholipids. P(4)-ATPases form heteromeric complexes with Cdc50 proteins. The primary role of these additional polypeptides is unknown. Here, we show that the affinity of yeast P(4)-ATPase Drs2p for its Cdc50-binding partner fluctuates during the transport cycle, with the strongest interaction occurring at a point where the enzyme is loaded with phospholipid ligand. We also find that specific interactions with Cdc50p are required to render the ATPase competent for phosphorylation at the catalytically important aspartate residue. Our data indicate that Cdc50 proteins are integral components of the P(4)-ATPase transport machinery. Thus, acquisition of these subunits may have been a crucial step in the evolution of flippases from a family of cation pumps. PMID:19411703

  7. Charmed baryon strong decays in a chiral quark model

    SciTech Connect

    Zhong Xianhui; Zhao Qiang

    2008-04-01

    Charmed baryon strong decays are studied in a chiral quark model. The data for the decays of {lambda}{sub c}{sup +}(2593), {lambda}{sub c}{sup +}(2625), {sigma}{sub c}{sup ++,+,0}, and {sigma}{sub c}{sup +,0}(2520) are accounted for successfully, which allows one to fix the pseudoscalar-meson-quark couplings in an effective chiral Lagrangian. Extending this framework to analyze the strong decays of the newly observed charmed baryons, we classify that {lambda}{sub c}(2880) and {lambda}{sub c}(2940) as D-wave states in the N=2 shell; {lambda}{sub c}(2880) could be |{lambda}{sub c}{sup 2}D{sub {lambda}}{sub {lambda}}(3/2){sup +}> and {lambda}{sub c}(2940) could be |{lambda}{sub c}{sup 2}D{sub {lambda}}{sub {lambda}}(5/2){sup +}>. Our calculation also suggests that {lambda}{sub c}(2765) is very likely a {rho}-mode P-wave excited state in the N=1 shell, and favors a |{lambda}{sub c}{sup 4}P{sub {rho}}(1/2){sup -}> configuration. The {sigma}{sub c}(2800) favors being a |{sigma}{sub c}{sup 2}P{sub {lambda}}(1/2){sup -}> state. But its being |{sigma}{sub c}{sup ++4}P{sub {lambda}}(5/2){sup -}> cannot be ruled out.

  8. Universal decay law in charged-particle emission and exotic cluster radioactivity.

    PubMed

    Qi, C; Xu, F R; Liotta, R J; Wyss, R

    2009-08-14

    A linear universal decay formula is presented starting from the microscopic mechanism of the charged-particle emission. It relates the half-lives of monopole radioactive decays with the Q values of the outgoing particles as well as the masses and charges of the nuclei involved in the decay. This relation is found to be a generalization of the Geiger-Nuttall law in alpha radioactivity and explains well all known cluster decays. Predictions on the most likely emissions of various clusters are presented. PMID:19792636

  9. Effect of room air recirculation delay on the decay rate of tracer gas concentration

    SciTech Connect

    Kristoffersen, A.R.; Gadgil, A.J.; Lorenzetti, D.M.

    2004-05-01

    Tracer gas measurements are commonly used to estimate the fresh air exchange rate in a room or building. Published tracer decay methods account for fresh air supply, infiltration, and leaks in ductwork. However, the time delay associated with a ventilation system recirculating tracer back to the room also affects the decay rate. We present an analytical study of tracer gas decay in a well-mixed, mechanically-ventilated room with recirculation. The analysis shows that failing to account for delays can lead to under- or over-estimates of the fresh air supply, depending on whether the decay rate calculation includes the duct volume.

  10. Measurement of exclusive baryon-antibaryon decays of {chi}{sub cJ} mesons

    SciTech Connect

    Naik, P.; Rademacker, J.; Asner, D. M.; Edwards, K. W.; Reed, J.; Briere, R. A.; Ferguson, T.; Tatishvili, G.; Vogel, H.; Watkins, M. E.; Rosner, J. L.; Alexander, J. P.; Cassel, D. G.; Duboscq, J. E.; Ehrlich, R.; Fields, L.; Gibbons, L.; Gray, R.; Gray, S. W.; Hartill, D. L.

    2008-08-01

    Using a sample of 2.59x10{sup 7} {psi}(2S) decays collected by the CLEO-c detector, we present results of a study of {chi}{sub cJ} (J=0, 1, 2) decays into baryon-antibaryon final states. We present the world's most precise measurements of the {chi}{sub cJ}{yields}pp and {chi}{sub cJ}{yields}{lambda}{lambda} branching fractions, and the first measurements of {chi}{sub c0} decays to other hyperons. These results illuminate the decay mechanism of the {chi}{sub c} states.

  11. Neutrinoless double-β decay and nuclear transition matrix elements

    SciTech Connect

    Rath, P. K.

    2015-10-28

    Within mechanisms involving the light Majorana neutrinos, squark-neutrino, Majorons, sterile neutrinos and heavy Majorana neutrino, nuclear transition matrix elements for the neutrinoless (β{sup −}β{sup −}){sub 0ν} decay of {sup 96}Zr, {sup 100}Mo, {sup 128,130}Te and {sup 150}Nd nuclei are calculated by employing the PHFB approach. Effects due to finite size of nucleons, higher order currents, short range correlations, and deformations of parent as well as daughter nuclei on the calculated matrix elements are estimated. Uncertainties in nuclear transition matrix elements within long-ranged mechanisms but for double Majoron accompanied (β{sup −}β{sup −}ϕϕ){sub 0ν} decay modes are 9%–15%. In the case of short ranged heavy Majorona neutrino exchange mechanism, the maximum uncertainty is about 35%. The maximum systematic error within the mechanism involving the exchange of light Majorana neutrino is about 46%.

  12. Neutrinoless double-β decay and nuclear transition matrix elements

    NASA Astrophysics Data System (ADS)

    Rath, P. K.

    2015-10-01

    Within mechanisms involving the light Majorana neutrinos, squark-neutrino, Majorons, sterile neutrinos and heavy Majorana neutrino, nuclear transition matrix elements for the neutrinoless (β-β-)0ν decay of 96Zr, 100Mo, 128,130Te and 150Nd nuclei are calculated by employing the PHFB approach. Effects due to finite size of nucleons, higher order currents, short range correlations, and deformations of parent as well as daughter nuclei on the calculated matrix elements are estimated. Uncertainties in nuclear transition matrix elements within long-ranged mechanisms but for double Majoron accompanied (β-β-ϕϕ)0ν decay modes are 9%-15%. In the case of short ranged heavy Majorona neutrino exchange mechanism, the maximum uncertainty is about 35%. The maximum systematic error within the mechanism involving the exchange of light Majorana neutrino is about 46%.

  13. The search for proton decay

    SciTech Connect

    Haines, T.; Kaneyuki, K.; McGrew, C.; Mohapatra, R.; Peterson, E.; Cline, D.B.

    1994-12-31

    The conservation of the quantum number called baryon number, like lepton (or family) number, is an empirical fact even though there are very good reasons to expect otherwise. Experimentalists have been searching for baryon number violating decays of the proton and neutron for decades now without success. Theorists have evolved deep understanding of the relationship between the natural forces in the development of various Grand Unified Theories (GUTs) that nearly universally predict baryon number violating proton decay, or related phenomena like n-{bar n} oscillations. With this in mind, the Proton Decay Working Group reviewed the current experimental and theoretical status of the search for baryon number violation with an eye to the advancement in the next decade.

  14. Tunneling decay of false kinks

    NASA Astrophysics Data System (ADS)

    Dupuis, Éric; Gobeil, Yan; MacKenzie, Richard; Marleau, Luc; Paranjape, M. B.; Ung, Yvan

    2015-07-01

    We consider the decay of "false kinks," that is, kinks formed in a scalar field theory with a pair of degenerate symmetry-breaking false vacua in 1 +1 dimensions. The true vacuum is symmetric. A second scalar field and a peculiar potential are added in order for the kink to be classically stable. We find an expression for the decay rate of a false kink. As with any tunneling event, the rate is proportional to exp (-SE) where SE is the Euclidean action of the bounce describing the tunneling event. This factor varies wildly depending on the parameters of the model. Of interest is the fact that for certain parameters SE can get arbitrarily small, implying that the kink is only barely stable. Thus, while the false vacuum itself may be very long-lived, the presence of kinks can give rise to rapid vacuum decay.

  15. Observable signatures of inflaton decays

    SciTech Connect

    Battefeld, Diana; Battefeld, Thorsten; Giblin, John T. Jr.; Pease, Evan K. E-mail: tbattefe@astro.physik.uni-goettingen.de E-mail: peasee@kenyon.edu

    2011-02-01

    We numerically compute features in the power-spectrum that originate from the decay of fields during inflation. Using a simple, phenomenological, multi-field setup, we increase the number of fields from a few to thousands. Whenever a field decays, its associated potential energy is transferred into radiation, causing a jump in the equation of state parameter and mode mixing at the perturbed level. We observe discrete steps in the power-spectrum if the number of fields is low, in agreement with analytic arguments in the literature. These features become increasingly smeared out once many fields decay within a given Hubble time. In this regime we confirm the validity of the analytic approach to staggered inflation, which is based on a coarse-graining procedure. Our numerical approach bridges the aforementioned analytic treatments, and can be used in more complicated scenarios.

  16. Free radical decay in adamantane

    SciTech Connect

    Tegowski, A.T.; Pratt, D.W.

    1984-01-11

    Kinetic electron paramagnetic resonance (EPR) techniques have been used to characterize the decay behavior of the ''stable'' free radical 2-cyclohexanonyl in the plastic crystal phase f an adamantane matrix over the temperature range 257-313 K. Typical plots of the EPR signal intensity as a function of time are biexponential in nature, suggesting the existence of at least two channels for free radical decay. The activation parameters for both processes have been measured in both protonated and deuterated samples. A comparison of these results with those in other systems suggests that the host does, as expected, considerably reduce the pre-exponential factors for decay of the radical by bimolecular processes but has relatively little influence on the corresponding activation energies. 3 figures.

  17. EC decay of 244Bk

    NASA Astrophysics Data System (ADS)

    Sodaye, Suparna; Tripathi, R.; Sudarshan, K.; Sharma, S. K.; Pujari, P. K.; Palit, R.; Mukhopadhyay, S.

    2014-12-01

    Berkelium isotopes have been produced in 11B-induced reaction on 238U. The EC decay of 244Bk → 244Cm has been studied by carrying out the single and coincidence measurements of the γ-rays emitted during the de-excitation of the 244Cm levels. Radiochemical separations have been carried out to minimize the contribution from the fission products and target. The new half-life of 244Bk is obtained as 5.02 ± 0.03 h, which is close to the theoretically calculated value. The relative intensities of the decay γ-rays have been re-evaluated. Based on the coincidence measurements, a tentative partial level scheme for 244Bk → 244Cm decay has been proposed.

  18. Heavy quark spectroscopy and decay

    SciTech Connect

    Schindler, R.H.

    1987-01-01

    The understanding of q anti q systems containing heavy, charmed, and bottom quarks has progressed rapidly in recent years, through steady improvements in experimental techniques for production and detection of their decays. These lectures are meant to be an experimentalist's review of the subject. In the first of two lectures, the existing data on the spectroscopy of the bound c anti c and b anti b systems will be discussed. Emphasis is placed on comparisons with the theoretical models. The second lecture covers the rapidly changing subject of the decays of heavy mesons (c anti q and b anti q), and their excited states. In combination, the spectroscopy and decays of heavy quarks are shown to provide interesting insights into both the strong and electroweak interactions of the heavy quarks. 103 refs., 39 figs.

  19. A Small Conserved Domain in the Yeast Spa2p Is Necessary and Sufficient for Its Polarized Localization

    PubMed Central

    Arkowitz, Robert A.; Lowe, Nick

    1997-01-01

    SPA2 encodes a yeast protein that is one of the first proteins to localize to sites of polarized growth, such as the shmoo tip and the incipient bud. The dynamics and requirements for Spa2p localization in living cells are examined using Spa2p green fluorescent protein fusions. Spa2p localizes to one edge of unbudded cells and subsequently is observable in the bud tip. Finally, during cytokinesis Spa2p is present as a ring at the mother–daughter bud neck. The bud emergence mutants bem1 and bem2 and mutants defective in the septins do not affect Spa2p localization to the bud tip. Strikingly, a small domain of Spa2p comprised of 150 amino acids is necessary and sufficient for localization to sites of polarized growth. This localization domain and the amino terminus of Spa2p are essential for its function in mating. Searching the yeast genome database revealed a previously uncharacterized protein which we name, Sph1p (Spa2p homolog), with significant homology to the localization domain and amino terminus of Spa2p. This protein also localizes to sites of polarized growth in budding and mating cells. SPH1, which is similar to SPA2, is required for bipolar budding and plays a role in shmoo formation. Overexpression of either Spa2p or Sph1p can block the localization of either protein fused to green fluorescent protein, suggesting that both Spa2p and Sph1p bind to and are localized by the same component. The identification of a 150–amino acid domain necessary and sufficient for localization of Spa2p to sites of polarized growth and the existence of this domain in another yeast protein Sph1p suggest that the early localization of these proteins may be mediated by a receptor that recognizes this small domain. PMID:9214378

  20. The study of rare decays

    NASA Astrophysics Data System (ADS)

    Ju, Wan-Li; Wang, Guo-Li; Fu, Hui-Feng; Wang, Tian-Hong; Jiang, Yue

    2014-04-01

    In this paper, we study rare decays within the Standard Model. The penguin, box, annihilation, color-favored cascade and color-suppressed cascade contributions are included. Based on our calculation, the annihilation and color-favored cascade diagrams play important roles in the differential branching fractions, forward-backward asymmetries, longitudinal polarizations of the final vector mesons and leptonic longitudinal polarization asymmetries. More importantly, color-favored cascade decays largely enhance the resonance cascade contributions. To avoid the resonance cascade contribution pollution, new cutting regions are put forward.

  1. Laser-Assisted Muon Decay

    SciTech Connect

    Liu Aihua; Li Shumin; Berakdar, Jamal

    2007-06-22

    We show theoretically that the muon lifetime can be changed dramatically by embedding the decaying muon in a strong linearly polarized laser field. Evaluating the S-matrix elements taking all electronic multiphoton processes into account we find that a CO{sub 2} laser with an electric field amplitude of 10{sup 6} V cm{sup -1} results in an order of magnitude shorter lifetime of the muon. We also analyze the dependencies of the decay rate on the laser frequency and intensity.

  2. P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity.

    PubMed

    Gao, Sizhi; Witte, Michael M; Scott, Robert E

    2002-05-01

    P2P-R is a nuclear protein that can bind both p53 and Rb1. Its functions include roles in the control of RNA metabolism, apoptosis, and p53-dependent transcription. The expression of P2P-R also is repressed in G1 arrested terminally differentiated cells. The current studies therefore evaluated if P2P-R undergoes cell cycle-associated changes in its abundance and/or localization. Western blots show that relative to G0 quiescent cells, P2P-R protein levels are higher in populations of G2/M cells prepared by the physiological parasynchronization technique of serum deprivation followed by serum stimulation. More striking is the > 10-fold enrichment of P2P-R protein in specimens of highly purified mitotic cells prepared by the mitotic shake-select technique, or by synchrony with the mitotic spindle disruption agents nocodazole or vinblastine. These changes in P2P-R protein occur without a concomitant change in P2P-R mRNA expression suggesting that P2P-R immunoreactivity increases during mitosis. Confocal microscopy next established the localization of P2P-R to nucleoli in interphase cells and at the periphery of chromosomes in mitotic cells that lack nucleoli. The high levels of P2P-R localized to the periphery of chromosomes in mitotic cells suggest that P2P-R shares characteristics with other nucleolar proteins that associate with the periphery of chromosomes during mitosis. These include: nucleolin, B23, Ki67, and fibrillarin. PMID:12064457

  3. Molecular Orbital Simulations of Metal 1s2p Resonant Inelastic X-ray Scattering.

    PubMed

    Guo, Meiyuan; Källman, Erik; Sørensen, Lasse Kragh; Delcey, Mickaël G; Pinjari, Rahul V; Lundberg, Marcus

    2016-07-28

    For first-row transition metals, high-resolution 3d electronic structure information can be obtained using resonant inelastic X-ray scattering (RIXS). In the hard X-ray region, a K pre-edge (1s→3d) excitation can be followed by monitoring the dipole-allowed Kα (2p→1s) or Kβ (3p→1s) emission, processes labeled 1s2p or 1s3p RIXS. Here the restricted active space (RAS) approach, which is a molecular orbital method, is used for the first time to study hard X-ray RIXS processes. This is achieved by including the two sets of core orbitals in different partitions of the active space. Transition intensities are calculated using both first- and second-order expansions of the wave vector, including, but not limited to, electric dipoles and quadrupoles. The accuracy of the approach is tested for 1s2p RIXS of iron hexacyanides [Fe(CN)6](n-) in ferrous and ferric oxidation states. RAS simulations accurately describe the multiplet structures and the role of 2p and 3d spin-orbit coupling on energies and selection rules. Compared to experiment, relative energies of the two [Fe(CN)6](3-) resonances deviate by 0.2 eV in both incident energy and energy transfer directions, and multiplet splittings in [Fe(CN)6](4-) are reproduced within 0.1 eV. These values are similar to what can be expected for valence excitations. The development opens the modeling of hard X-ray scattering processes for both solution catalysts and enzymatic systems. PMID:27398775

  4. Affinity Purification and Characterization of a G-Protein Coupled Receptor, Saccharomyces cerevisiae Ste2p

    SciTech Connect

    Lee, Byung-Kwon; Jung, Kyung-Sik; Son, Cagdas D; Kim, Heejung; Verberkmoes, Nathan C; Arshava, Boris; Naider, Fred; Becker, Jeffrey Marvin

    2007-01-01

    We present a rare example of a biologically active G protein coupled receptor (GPCR) whose purity and identity were verified by mass spectrometry after being purified to near homogeneity from its native system. An overexpression vector was constructed to encode the Saccharomyces cerevisiae GPCR -factor receptor (Ste2p, the STE2 gene product) containing a 9-amino acid sequence of rhodopsin that served as an epitope/affinity tag. In the construct, two glycosylation sites and two cysteine residues were removed to aid future structural and functional studies. The receptor was expressed in yeast cells and was detected as a single band in a western blot indicating the absence of glycosylation. Tests of the epitope-tagged, mutated receptor showed it maintained its full biological activity. For extraction of Ste2p, yeast membranes were solubilized with 0.5 % n-dodecyl maltoside (DM). Approximately 120 g of purified -factor receptor was obtained per liter of culture by single-step affinity chromatography using a monoclonal antibody to the rhodopsin epitope. The binding affinity (Kd) of the purified -factor receptor in DM micelles was 28 nM as compared to Kd = 12.7 nM for Ste2p in cell membranes, and approximately 40 % of the purified receptor was correctly folded as judged by ligand saturation binding. About 50 % of the receptor sequence was retrieved from MALDITOF and nanospray mass spectrometry after CNBr digestion of the purified receptor. The methods described will enable structural studies of the -factor receptor and may provide an efficient technique to purify other GPCRs that have been functionally expressed in yeast.

  5. Investigations on the charmless decay modes of Zc(3900 ) and Zc(4025 )

    NASA Astrophysics Data System (ADS)

    Wu, Qi; Li, Gang; Shao, Fenglan; Wang, Ruiqin

    2016-07-01

    To date, the nature of Zc(3900 )/Zc(4025 ) is not clear. In this work, we propose to study the internal structure of Zc(3900 )/Zc(4025 ) by exploring the charmless decays. Compared to charmed decays, charmless decay channels may play a unique role since they request the annihilation of the heavy constituents. We calculate the decay width for Zc(3900 )/Zc(4025 )→V P , where P and V denote the pseudoscalar and light vector meson, respectively. Here, the Zc(3900 ) and Zc(4025 ) are the molecular states of D*D ¯ and D*D¯*. The decay process occurs through intermediate D D*/D*D* meson loops. Based on an effective Lagrangian, we obtain sizable predictions for the branching ratios, which are accessible in experiments. The experimental measurements in the future will not only shed light on the decay mechanism but will also lead to a deeper understanding of the mysterious structure of the Zc(3900 )/Zc(4025 ).

  6. Decay Data Evaluation Project (DDEP): evaluation of the main 233Pa decay characteristics.

    PubMed

    Chechev, Valery P; Kuzmenko, Nikolay K

    2006-01-01

    The results of a decay data evaluation are presented for 233Pa (beta-) decay to nuclear levels in 233U. These evaluated data have been obtained within the Decay Data Evaluation Project using information published up to 2005. PMID:16574422

  7. Gravitino decay and the cosmic gamma-ray background

    NASA Technical Reports Server (NTRS)

    Stecker, F. W.

    1986-01-01

    It is argued that the cosmic gamma-ray background (CGB) spectrum does not exhibit evidence for the decay of light gravitinos, in contradiction to the suggestion by Olive and Silk (1985), who observed a bump near 1 MeV in the CGB radiation spectrum. It is suggested that better fits to the CGB spectrum would be provided by mechanisms generating a power-law spectrum which is flattened below about 2 MeV. Olive and Silk maintain that the decays of a long-lived particle such as the gravitino may be responsible for features in the gamma-ray spectrum near 1 MeV.

  8. Democratic Decay of Be6 Exposed by Correlations

    NASA Astrophysics Data System (ADS)

    Egorova, I. A.; Charity, R. J.; Grigorenko, L. V.; Chajecki, Z.; Coupland, D.; Elson, J. M.; Ghosh, T. K.; Howard, M. E.; Iwasaki, H.; Kilburn, M.; Lee, Jenny; Lynch, W. G.; Manfredi, J.; Marley, S. T.; Sanetullaev, A.; Shane, R.; Shetty, D. V.; Sobotka, L. G.; Tsang, M. B.; Winkelbauer, J.; Wuosmaa, A. H.; Youngs, M.; Zhukov, M. V.

    2012-11-01

    The interaction of an E/A=70-MeV Be7 beam with a Be target was used to populate levels in Be6 following neutron knockout reactions. The three-body decay of the ground and first excited states into the α+p+p exit channel were detected in the High Resolution Array. Precise three-body correlations extracted from the experimental data allowed us to obtain insight into the mechanism of the three-body democratic decay. The correlation data are in good agreement with a three-cluster-model calculation and thus validate this theoretical approach over a broad energy range.

  9. Power-law photoluminescence decay in quantum dots

    SciTech Connect

    Král, Karel; Menšík, Miroslav

    2014-05-15

    Some quantum dot samples show a long-time (power-law) behavior of their luminescence intensity decay. This effect has been recently explained as being due to a cooperation of many tunneling channels transferring electrons from small quantum dots with triplet exciton to quantum dots at which the electrons can recombine with the holes in the valence band states. In this work we show that the long-time character of the sample luminescence decay can also be caused by an intrinsic property of a single dot, namely, by a non-adiabatic effect of the electron occupation up-conversion caused by the electron-phonon multiple scattering mechanism.

  10. Towards Accurate Node-Based Detection of P2P Botnets

    PubMed Central

    2014-01-01

    Botnets are a serious security threat to the current Internet infrastructure. In this paper, we propose a novel direction for P2P botnet detection called node-based detection. This approach focuses on the network characteristics of individual nodes. Based on our model, we examine node's flows and extract the useful features over a given time period. We have tested our approach on real-life data sets and achieved detection rates of 99-100% and low false positives rates of 0–2%. Comparison with other similar approaches on the same data sets shows that our approach outperforms the existing approaches. PMID:25089287

  11. Acoustic and elastic properties of Sn(2)P(2)S(6) crystals.

    PubMed

    Mys, O; Martynyuk-Lototska, I; Grabar, A; Vlokh, R

    2009-07-01

    We present the results concerned with acoustic and elastic properties of Sn(2)P(2)S(6) crystals. The complete matrices of elastic stiffness and compliance coefficients are determined in both the crystallographic coordinate system and the system associated with eigenvectors of the elastic stiffness tensor. The acoustic slowness surfaces are constructed and the propagation and polarization directions of the slowest acoustic waves promising for acousto-optic interactions are determined on this basis. The acoustic obliquity angle and the deviation of polarization of the acoustic waves from purely transverse or longitudinal states are quantitatively analysed. PMID:21828470

  12. Aneurysms of the P2P Segment of Posterior Cerebral Artery: Case Report and Surgical Steps.

    PubMed

    Aguiar, Paulo; Gatto, Luana; Neves, Maick; Martins, Carlos; Nakasone, Fabio; Isolan, Gustavo

    2014-01-01

    The posterior cerebral artery (PCA) is divided into 4 segments: precommunicating segment (P1), postcommunicating segment (P2), quadrigeminal segment (P3), and calcarine segment (P4). Small aneurysms are more prevalent than large aneurysms in patients with ruptured aneurysms. P2 and P3 aneurysms are usually managed by the subtemporal approach. This is a case report of rupture saccular aneurysm of posterior cerebral artery on P2P segment. The authors show the surgical steps of these rare aneurysms with an illustrative case. PMID:25548571

  13. Aneurysms of the P2P Segment of Posterior Cerebral Artery: Case Report and Surgical Steps

    PubMed Central

    Aguiar, Paulo; Neves, Maick; Martins, Carlos; Nakasone, Fabio; Isolan, Gustavo

    2014-01-01

    The posterior cerebral artery (PCA) is divided into 4 segments: precommunicating segment (P1), postcommunicating segment (P2), quadrigeminal segment (P3), and calcarine segment (P4). Small aneurysms are more prevalent than large aneurysms in patients with ruptured aneurysms. P2 and P3 aneurysms are usually managed by the subtemporal approach. This is a case report of rupture saccular aneurysm of posterior cerebral artery on P2P segment. The authors show the surgical steps of these rare aneurysms with an illustrative case. PMID:25548571

  14. Towards accurate node-based detection of P2P botnets.

    PubMed

    Yin, Chunyong

    2014-01-01

    Botnets are a serious security threat to the current Internet infrastructure. In this paper, we propose a novel direction for P2P botnet detection called node-based detection. This approach focuses on the network characteristics of individual nodes. Based on our model, we examine node's flows and extract the useful features over a given time period. We have tested our approach on real-life data sets and achieved detection rates of 99-100% and low false positives rates of 0-2%. Comparison with other similar approaches on the same data sets shows that our approach outperforms the existing approaches. PMID:25089287

  15. Electronic Structure and Phase Transition in Ferroelectic Sn2P2S6 Crystal

    PubMed Central

    Glukhov, Konstantin; Fedyo, Kristina; Banys, Juras; Vysochanskii, Yulian

    2012-01-01

    An analysis of the P2S6 cluster electronic structure and its comparison with the crystal valence band in the paraelectric and ferroelectric phases has been done by first-principles calculations for Sn2P2S6 ferroelectrics. The origin of ferroelectricity has been outlined. It was established that the spontaneous polarization follows from the stereochemical activity of the electron lone pair of tin cations, which is determined by hybridization with P2S6 molecular orbitals. The chemical bonds covalence increase and rearrangement are related to the valence band changes at transition from the paraelectric phase to the ferroelectric phase. PMID:23203069

  16. Upc2p-associated differential protein expression in Candida albicans.

    PubMed

    Hoehamer, Christopher F; Cummings, Edwin D; Hilliard, George M; Morschhäuser, Joachim; David Rogers, Phillip

    2009-10-01

    The gain-of-function mutation G648D in UPC2 causes ERG11 up-regulation and increased fluconazole resistance in Candida albicans. In this study, we performed 2-DE and PMF to identify proteomic alterations in an ERG11-overexpressing fluconazole-resistant C. albicans clinical isolate compared with its fluconazole-susceptible parent strain. We identified 23 differentially expressed proteins, and among them, seven became differentially expressed in a C. albicans wild-type strain after the introduction of a UPC2 allele carrying this mutation. These Upc2p-regulated proteins may contribute to fluconazole resistance in C. albicans. PMID:19750515

  17. PD2P: PanDA Dynamic Data Placement for ATLAS

    NASA Astrophysics Data System (ADS)

    Maeno, T.; De, K.; Panitkin, S.

    2012-12-01

    The PanDA (Production and Distributed Analysis) system plays a key role in the ATLAS distributed computing infrastructure. PanDA is the ATLAS workload management system for processing all Monte-Carlo (MC) simulation and data reprocessing jobs in addition to user and group analysis jobs. The PanDA Dynamic Data Placement (PD2P) system has been developed to cope with difficulties of data placement for ATLAS. We will describe the design of the new system, its performance during the past year of data taking, dramatic improvements it has brought about in the efficient use of storage and processing resources, and plans for the future.

  18. Single-photon multiple ionization forming double vacancies in the 2p subshell of argon

    NASA Astrophysics Data System (ADS)

    Linusson, P.; Fritzsche, S.; Eland, J. H. D.; Mucke, M.; Feifel, R.

    2013-04-01

    Single-photon ionization leading to two vacancies in the 2p subshell of argon is investigated experimentally using the photoelectron time-of-flight magnetic bottle coincidence technique. Three peaks corresponding to the 3P, 1D, and 1S states of the dication are found in the ionization energy range 535 to 562 eV. Multiconfigurational Dirac-Fock calculations were performed to estimate the single-photon double-ionization cross sections. Reasonable agreement between the measured and simulated spectra is found if single and double excitations are taken into account in the wave-function expansion.

  19. Magnetic and magnetocaloric exploration of Fe rich (Mn,Fe)2(P,Ge)

    NASA Astrophysics Data System (ADS)

    Leitão, J. V.; van der Haar, M.; Lefering, A.; Brück, E.

    2013-10-01

    We explored the Fe rich side of the (Mn,Fe)2(P,Ge) magnetocaloric system. The transition temperature of this system is extremely easy to tune with careful manipulation of Fe and Ge content as well as stoichiometrical proportions, which give rise to the real possibility of lowering the price of this compound and thus make it economically viable for practical magnetocaloric applications. Novel and unexpected magnetic properties observed in this system suggest an exciting potential for permanent magnet application in a limited concentration range.

  20. The influence of auxiliary codopants on persistent phosphor Sr{sub 2}P{sub 2}O{sub 7}:Eu{sup 2+},R{sup 3+} (R = Y, La, Ce, Gd, Tb and Lu)

    SciTech Connect

    Ju, Guifang; Hu, Yihua Chen, Li; Wang, Xiaojuan; Mu, Zhongfei

    2013-11-15

    Graphical abstract: Rare earth ions which close to the line are good codopants. - Highlights: • The persistent luminescence in Sr{sub 2}P{sub 2}O{sub 7}:Eu{sup 2+},R{sup 3+} was reported. • Sr{sub 2}P{sub 2}O{sub 7}:Eu{sup 2+},Lu{sup 3+} shows the best performance. • The influence of auxiliary codopants was discussed in terms of ionic potential and ionic radius. - Abstract: We investigate the persistent luminescence in europium-doped strontium pyrophosphate upon codoping with auxiliary rare earth ions. The persistent phosphors are synthesized via solid-state reaction method under flowing N{sub 2} + H{sub 2}. Under UV irradiation, broadband emission persistent luminescence located at 420 nm is observed in all of these phosphors at room temperature. The effects of auxiliary rare earth ions on Sr{sub 2}P{sub 2}O{sub 7}:Eu{sup 2+} are discussed according to the decay curves and thermoluminescence spectra. Sr{sub 2}P{sub 2}O{sub 7}:Eu{sup 2+},Lu{sup 3+} shows the best performance, while and La{sup 3+} and Ce{sup 3+} codoped samples are the weakest. The influence of auxiliary codopants is discussed in terms of ionic potential and ionic radius. We derive an empirical formula based on the experimental results.