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1

Multipurpose Spaces  

ERIC Educational Resources Information Center

|The concept of multipurpose spaces in schools is certainly not new. Especially in elementary schools, the combination of cafeteria and auditorium (and sometimes indoor physical activity space as well) is a well-established approach to maximizing the use of school space and a school district's budget. Nonetheless, there continue to be refinements…

Gordon, Douglas

2010-01-01

2

Safety of Multipurpose Vans.  

National Technical Information Service (NTIS)

Since 1970, the sales of multipurpose vans have increased threefold. Vans are popular because of their versatility; outdoorsmen, small businessmen, service technicians, and the 'weekend vanner' are using vans for personal transportation, business operatio...

1979-01-01

3

Multipurpose marine Buoy  

Microsoft Academic Search

Solving the meteorological and oceanographic monitoring problems in frame of the actual ldquoJadran Projectrdquo the multipurpose marine buoy was developed to meat specific requirements in Adriatic Sea. The aluminum plastic coated buoy was designed to ensure stabile behavior at any waves high and wind speed that can occur in Adriatic aquatory. The 3 m high upper platform is provided for

Tomislav Tomiša; Slavko Krajcar; D. Pinezic

2008-01-01

4

Multipurpose Visualization System  

Microsoft Academic Search

This paper deals with the design and architecture of the low cost multipurpose flight visualization system (MFVS). The MFVS system was originally developed as a passive IFR approach system for general aviation small planes. A relatively high adaptability is one of the main advantages. It can be easily used with many types of avionics devices. The GPS\\/INS system is used

P. Bojda; P. Frantis

2006-01-01

5

Multipurpose Reprocessing Hot Cell.  

National Technical Information Service (NTIS)

A multipurpose hot cell for use in the new head end system is described. The use of a hot cell as part of the routine fuel charging procedure provides considerable flexibility in handling a wide variety of fuel sizes up to 25,000 lb.

R. D. Fletcher

1975-01-01

6

Multipurpose Compact Spectrometric Unit  

NASA Astrophysics Data System (ADS)

A new standalone compact spectrometer was developed. The device consists of analog (peamplifier, amplifier) and digital parts. The digital part is based on the 160 MIPS Digital Signal Processor. It contains 20 Msps Flash-ADC, 1 MB RAM for spectra storage, 128 KB Flash/ROM for firmware storage, Real Time Clock and several voltage regulators providing the power for user peripherals (e.g. amplifier, temperature sensors, etc.). Spectrometer is connected with a notebook via high-speed USB 2.0 bus. The spectrometer is multipurpose device, which is planned to be used for measurements of Rn activities, energy of detected particles by CdTe pixel detector or for coincidence measurements.

Bo?arov, Viktor; ?ermák, Pavel; Mamedov, Fadahat; Štekl, Ivan

2009-11-01

7

Multi-purpose seismic transducer  

SciTech Connect

A multi-purpose seismic transducer includes a first seismic sensor having a first transfer function. A transfer-function shaping filter is coupled to the output of the first seismic sensor. The filter is adjustable to shape the first transfer function to match a plurality of different second transfer functions.

Hall, E.M.

1981-02-24

8

Multipurpose system for ecological monitoring  

Microsoft Academic Search

Moscow Research Television Institute has conducted theoretical and experimental researches concerning the integration of image sensors operating in different ranges on board of vehicles. On the base of these researches a prototype of multipurpose system for ecological monitoring is made. The scope of the system: ecological monitoring of each and water surface, control of sources of pollution and zones of

V. M. Berezansky

1997-01-01

9

21 CFR 866.2300 - Multipurpose culture medium.  

Code of Federal Regulations, 2013 CFR

...2013-04-01 false Multipurpose culture medium. 866.2300 Section 866.2300 Food...Devices § 866.2300 Multipurpose culture medium. (a) Identification. A multipurpose culture medium is a device that consists...

2013-04-01

10

An inexpensive, multipurpose physical pendulum  

NASA Astrophysics Data System (ADS)

The pendulum is a highly versatile tool for teaching physics. Many special purpose pendula for student experiments have been described.1-4 In this paper, I describe an inexpensive, multipurpose physical pendulum that can function as both a variable gravity and ballistic pendulum. I designed the apparatus for use in a rotational dynamics unit of the AP Physics C mechanics course. The use of a bike wheel hub pivot allows for low-friction, rugged operation that yields results commensurate with those obtained with much more expensive pendula available on the market (typically $500 per unit5), placing these types of experiments within reach of the teacher on a restricted budget.

Schultz, David

2012-10-01

11

Small multipurpose stored data acquisition system.  

National Technical Information Service (NTIS)

Sandia National Laboratories Telemetry Department has designed and is fielding a small, inexpensive multipurpose stored data acquisition system in tests ranging from 6000 meters below the ocean surface in seafloor penetrators to 40,000 meters above sea le...

G. C. Hauser D. E. Ryerson

1990-01-01

12

The Astrophysical Multipurpose Software Environment  

NASA Astrophysics Data System (ADS)

We present the open source Astrophysical Multi-purpose Software Environment (AMUSE), a component library for performing astrophysical simulations involving different physical domains and scales. It couples existing codes within a Python framework based on a communication layer using MPI. The interfaces are standardized for each domain and their implementation based on MPI guarantees that the whole framework is well-suited for distributed computation. It includes facilities for unit handling and data storage. Currently it includes codes for gravitational dynamics, stellar evolution, hydrodynamics and radiative transfer. Within each domain the interfaces to the codes are as similar as possible. We describe the design and implementation of AMUSE, as well as the main components and community codes currently supported and we discuss the code interactions facilitated by the framework. Additionally, we demonstrate how AMUSE can be used to resolve complex astrophysical problems by presenting example applications. http://www.amusecode.org The current version of the code is available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/557/A84

Pelupessy, F. I.; van Elteren, A.; de Vries, N.; McMillan, S. L. W.; Drost, N.; Portegies Zwart, S. F.

2013-09-01

13

[Multipurpose treatment of vaginal infections].  

PubMed

Untreated bacterial vaginosis is related with many complications for non-pregnant women in reproductive age, most common from them are vaginal discharge and postoperative infections. The aim of our investigation was to compare the effectiveness of two therapeutic regimes which consist in Macmiror/Macmiror Complex alone and in combination with Feminella Vagi C for treatment of bacterial vaginosis (BV) and/or mycotic infection. 117 non-pregnant women with symptoms of vaginal infection were prospectively enrolled into two groups according their treatment. First group consist 66 women treated with Macmiror tablets and vaginal capsules followed with local application of Feminella Vagi C, the second group consist 54 women treated with Macmiror tablets and vaginal capsules only. The impact of treatment on clinical symptoms was observed at the end of medication and 20 days after it. Microbiological testing was repeated 20 days after treatment. Over than 80% (78.6 divided by 86.7%) of the cases with vaginal infection (BV and mycotic one) were successfully treated with Macmiror/Macmiror Complex. Supplement treatment with Feminella Vagi C lead to higher percentage of clinically recovery (86.7% vs 84.6%), better microbiological cleaning (86.7% vs 82.1%) and longer effect of treatment. Used medication showed higher efficacy against BV than to fungal infection. According obtained results we may conclude that bacterial vaginosis was better treated with multipurpose treatment (Nifuratel, Nistatin and vit. C) than with Macmiror alone. PMID:23234030

Nikolov, A; Masseva, A; Shopova, E; Georgiev, S

2012-01-01

14

Small multipurpose stored data acquisition system  

Microsoft Academic Search

Sandia National Laboratories Telemetry Department has designed and is fielding a small, inexpensive multipurpose stored data acquisition system in tests ranging from 6000 meters below the ocean surface in seafloor penetrators to 40,000 meters above sea level in gamma ray telescope balloons. The systems consists of a simple microprocessor-controlled unit which digitizes analog data stores the data in memory for

G. C. Hauser; D. E. Ryerson

1990-01-01

15

How To Light a Multipurpose Facility.  

ERIC Educational Resources Information Center

|Highlights the questions to ask when designing or retrofitting the lighting needs for a multipurpose campus facility. Issues addressed include the tasks the facility is expected to accommodate, the benefits of available lighting sources, the facility's layout and dimensions, aesthetics and functionality, and budgetary considerations. (GR)|

Ries, Jack

1998-01-01

16

Positional errors of tools in multipurpose lathes  

Microsoft Academic Search

1 As the demands for accuracy and surface quality of machine parts continue to increase, it is very important to develop machining processes on the basis of consistent technological principles. Such consistency is best attained in multipurpose lathes, in which different processes (turning, milling, eccentric boring, etc.) may be performed within a single system. This involves the integration of a

A. F. Denisenko; V. I. Petrunin; O. Yu. Kazakova

2007-01-01

17

How To Light a Multipurpose Facility.  

ERIC Educational Resources Information Center

Highlights the questions to ask when designing or retrofitting the lighting needs for a multipurpose campus facility. Issues addressed include the tasks the facility is expected to accommodate, the benefits of available lighting sources, the facility's layout and dimensions, aesthetics and functionality, and budgetary considerations. (GR)

Ries, Jack

1998-01-01

18

Development of compact multipurpose ultrasonic technological device  

Microsoft Academic Search

In this work is described the potential range of applications of ultrasonic technologies in conditions of small-scale enterprises and the problems which limit such applications caused by the absence of low-cost compact multipurpose ultrasonic technological devices. The problems arising during compact ultrasonic device development are considered, and possible solutions given. The engineering solutions applied during the design of an oscillation

Vladimir N. Khmelev; Igor I. Savin; Roman V. Barsukov; Alexey N. Slivin; Sergey N. Tsyganok; Eugene V. Chipurin

2003-01-01

19

Metamodels for Planar 3R Workspace Optimization.  

SciTech Connect

Robotic workspace optimization is a central element of robot system design. To formulate the optimization problem, the complex relationships between design variables, tuning parameters, and performance indices need to be accurately and efficiently represented. The nature of the relationships suggests that metamodels, or models of the models, should be used to derive suitable objective functions. A comparison of two metamodeling techniques for robotic workspace optimization problems for several trial cases suggests that non-uniform rational B-spline models, derived from computer graphics and computer-aided design techniques, are as suitable as response surface models to solve planar 3R workspace optimization problems. Promising nonlinear modeling results with B-spline models suggest future work is justified and performance gains can be realized.

Turner, C. J. (Cameron J.)

2002-01-01

20

Extinguishing Class A fires with multipurpose chemicals  

Microsoft Academic Search

We investigated the extinguishing properties of multipurpose dry chemicals using openregime cribs of two sizes. One measured 20.3 by 20.3 by 15.2 cm, and the other 50.8 by 50.8 by 38 cm. A crib fire, which has both flaming and smoldering contributions, is primarily extinguished when the burning surfaces are covered or smothered by a gas phase of the original

Curtis T. Ewing; Francis R. Faith; James B. Romans; Charles W. Siegmann; Ralph J. Ouellette; J. Thomas Hughes; Homer W. Carhart

1995-01-01

21

Daily operation of a multipurpose reservoir system  

Microsoft Academic Search

An optimization model that may be used by reservoir system operators to improve daily, real-time operations and to evolve better long-term operating guidelines is developed and tested. The four multipurpose reservoirs in the Green River Basin (GRB) of Kentucky are used as a case study. The GRB Operation Optimization Model (GRBOOM) is a linear program constructed to imitate the decision-making

Hasan Yazicigil; Mark H. Houck; Gerrit H. Toebes

1983-01-01

22

A MULTIPURPOSE COHERENT INSTABILITY SIMULATION CODE  

SciTech Connect

A multipurpose coherent instability simulation code has been written, documented, and released for use. TRANFT (tran-eff-tee) uses fast Fourier transforms to model transverse wakefields, transverse detuning wakes and longitudinal wakefields in a computationally efficient way. Dual harmonic RF allows for the study of enhanced synchrotron frequency spread. When coupled with chromaticity, the theoretically challenging but highly practical post head-tail regime is open to study. Detuning wakes allow for transverse space charge forces in low energy hadron beams, and a switch allowing for radiation damping makes the code useful for electrons.

BLASKIEWICZ,M.

2007-06-25

23

Next Generation MultiPurpose Microprocessor  

NASA Astrophysics Data System (ADS)

The Next Generation Multipurpose Microprocessor (NGMP) is a SPARC V8(E) based multi-core architecture that provides a significant performance increase compared to earlier generations of European space processors. The NGMP is currently in development at Aeroflex Gaisler in Göteborg, Sweden, in an activity initiated by the European Space Agency (ESA). This paper describes the baseline architecture, points out key choices that have been made and emphasises design decisions that are still open. The software tools and operating systems that will be available for the NGMP, together with a general overview of the new LEON4FT microprocessor, are also described.

Andersson, J.; Gaisler, J.; Weigand, R.

2010-08-01

24

The design of a multipurpose tomography installation  

NASA Astrophysics Data System (ADS)

This paper describes a single photon emission tomography installation using high resolution gamma spectroscopy. Its multipurpose design allows direct measurements of the spatial activity distribution on sources of different geometries and tomography projections on fuel rods or pellets irradiated in the zero power critical facility VENUS. Two major constraints originating from the low activity of the samples are the limited number of measurements that can be performed and parasitic transmission through the collimator. This has resulted in the need to further optimise the design of the detector-collimator geometry.

Borms, L.; Oeyen, J.

1999-02-01

25

Multi-purpose neutron radiography system  

SciTech Connect

A conceptual design is given for a low cost, multipurpose radiography system suited for the needs of the Los Alamos National Laboratory (LANL). The proposed neutron source is californium-252. One purpose is to provide an in-house capability for occasional, reactor quality, neutron radiography thus replacing the recently closed Omega-West Reactor. A second purpose is to provide a highly reliable standby transportable neutron radiography system. A third purpose is to provide for transportable neutron probe gamma spectroscopy techniques. The cost is minimized by shared use of an existing x-ray facility, and by use of an existing transport cask. The achievable neutron radiography and radioscopy performance characteristics have been verified. The demonstrated image qualities range from high resolution gadolinium - SR film, with L:D = 100:1, to radioscopy using a LIXI image with L:D = 30:1 and neutron fluence 3.4 x 10{sup 5} n/cm{sup 2}.

Barton, J.P. [NRE Inc., San Diego, CA (United States); Bryant, L.E.; Berry, P. [Los Alamos National Lab., NM (United States)

1996-07-01

26

Daily operation of a multipurpose reservoir system  

SciTech Connect

An optimization model that may be used by reservoir system operators to improve daily, real-time operations and to evolve better long-term operating guidelines is developed and tested. The four multipurpose reservoirs in the Green River Basin (GRB) of Kentucky are used as a case study. The GRB Operation Optimization Model (GRBOOM) is a linear program constructed to imitate the decision-making process that results in actual reservoir release decisions. The model is easily modifiable and very flexible, which allows sensitivity analysis and experimentation with new operating guidelines. This experimentation should permit the operators to evolve improved operating policies. The inputs to the model are data that are readily available, and the outputs may be presented in easily interpreted graphical form.

Yazicigil, H.; Houck, M.H.; Toebes, G.H.

1983-02-01

27

Multipurpose Acoustic Sensor for Downhole Fluid Monitoring  

SciTech Connect

The projects objectives and purpose are to: (1) development a multipurpose acoustic sensor for downhole fluid monitoring in Enhanced Geothermal Systems (EGS) reservoirs over typical ranges of pressures and temperatures and demonstrate its capabilities and performance for different EGS systems; (2) determine in real-time and in a single sensor package several parameters - temperature, pressure, fluid flow and fluid properties; (3) needed in nearly every phase of an EGS project, including Testing of Injection and Production Wells, Reservoir Validation, Inter-well Connectivity, Reservoir Scale Up and Reservoir Sustainability. (4) Current sensors are limited to operating at lower temperatures, but the need is for logging at high temperatures. The present project deals with the development of a novel acoustic-based sensor that can work at temperatures up to 374 C, in inhospitable environments.

Pantea, Cristian [Los Alamos National Laboratory

2012-05-04

28

Research and Development of a Multipurpose Test Chassis. Final Report.  

National Technical Information Service (NTIS)

The objective of this contract was to design, fabricate, and laboratory test a multipurpose test chassis to provide transport, power, ancillary systems, and instrumentation for the testing of prototype roof drilling and bolting equipment. During the contr...

P. T. Alexander

1980-01-01

29

Multipurpose upper stage "Fregat-SB" with enhanced power capacity  

NASA Astrophysics Data System (ADS)

The description of the multipurpose upper stage "Fregat-SB" with enhanced power capacity is given in the article. The main parameters of the upper stage on different launchers and its advantages in comparison with the competitors are shown.

Asyushkin, V. A.; Ishin, S. V.

2012-12-01

30

[The "3R" concept in the Internet I  

PubMed

More and more members of the scientific community interested in 3R related topics of animal experiments are using Internet-Homepages as a low-budget forum to present either their scientific results, or opinions on specific subjects or to announce publications. Supra/inter/national authorities/universities/laboratories are also offering information, documents, access to databases and much more to the interested public. Therefore the Internet is an advantageous new medium for 3R related subjects. PMID:11178485

Falkner, Erwin; Hartbauer, Manfred; Schöffl, Harald; Appl, Helmut; Tritthart, Helmut A.

1997-01-01

31

Multipurpose robot for automated cycle sequencing.  

PubMed

Paramagnetic beads have the superior advantages of easy separation and resuspension by controlling the magnetic filed. Previously, we have developed Magtration technology to automate paramagnetic bead handling and have built several automated instruments that handle 1-12 samples simultaneously. To achieve more high-throughput sample processing, two types of a 96-arrayed Integrated Magtration Unit (IMU) were developed, one installed with electromagnets and the other with thin rod-shaped magnets made of neodymium. A multipurpose robot (SX-96GC) equipped with the IMU was also developed for fully automatic processing of 96 samples in parallel. The cleanup of dye-terminator sequencing products was performed using the robot installed with the permanent magnet version of IMU. The results had quality comparable to those by the same protocol in manual handling or to those by the conventional protocols. The robot processed 96 samples in a microplate within 30 min. The protocol that can purify 384 samples within 1 h by processing two microplates concurrently was successfully designed. PMID:12661168

Sawakami-Kobayashi, K; Segawa, O; Obata, K; Hornes, E; Yohda, M; Tajima, H; Machida, M

2003-03-01

32

Multipurpose simulation systems for regional development forecasting  

SciTech Connect

We examine the development of automaton-modeling multipurpose simulation systems as an efficient form of simulation software for MIS. Such systems constitute a single problem-oriented package of applications based on a general simulation model, which is equipped with a task source language, interaction tools, file management tools, and an output document editor. The simulation models are described by the method of probabilistic-automaton modeling, which ensures standard representation of models and standardization of the modeling algorithm. Examples of such systems include the demographic forecasting system DEPROG, the VOKON system for assessing the quality of consumer services in terms of free time, and the SONET system for servicing partially accessible customers. The development of computer-aided systems for production and economic control is now moving to the second state, namely operationalization of optimization and forecasting problems, whose solution may account for the main economic effect of MIS. Computation and information problems, which were the main focus of the first stage of MIS development, are thus acquiring the role of a source of information for optimization and forecasting problems in addition to their direct contribution to preparation and analysis of current production and economic information.

Kostina, N.I.

1995-09-01

33

Adsorption of Brilliant Scarlet 3R by Natural Diatomite  

Microsoft Academic Search

The adsorption of acid dyes by diatomite was investigated using Brilliant Scarlet 3R (NSK). Adsorption of this textile dyes onto diatomite earth sample was studied by batch adsorption techniques at varying temperatures 298 K, 309 K, 318 K, 328 K. The adsorption behavior of textile dye on diatomite samples was investigated using a UV-vis spectrophotometric technique. The adsorption processes follow

Shaohua He; Zhipan Gu; Jing Liu; Shuibo Xie

2009-01-01

34

Incorporating ecological requirement into multipurpose reservoir operating rule curves for adaptation to climate change  

NASA Astrophysics Data System (ADS)

We incorporate ecological requirement into multipurpose reservoir operating rule curves.We explore how multipurpose reservoir operating rule curves adapt to future climate change.Ecological supply water operation will alleviate negative effect of dam on river ecosystem.

Zhou, Yanlai; Guo, Shenglian

2013-08-01

35

Mutations in PIK3R1 cause SHORT syndrome.  

PubMed

SHORT syndrome is a rare, multisystem disease characterized by short stature, anterior-chamber eye anomalies, characteristic facial features, lipodystrophy, hernias, hyperextensibility, and delayed dentition. As part of the FORGE (Finding of Rare Disease Genes) Canada Consortium, we studied individuals with clinical features of SHORT syndrome to identify the genetic etiology of this rare disease. Whole-exome sequencing in a family trio of an affected child and unaffected parents identified a de novo frameshift insertion, c.1906_1907insC (p.Asn636Thrfs*18), in exon 14 of PIK3R1. Heterozygous mutations in exon 14 of PIK3R1 were subsequently identified by Sanger sequencing in three additional affected individuals and two affected family members. One of these mutations, c.1945C>T (p.Arg649Trp), was confirmed to be a de novo mutation in one affected individual and was also identified and shown to segregate with the phenotype in an unrelated family. The other mutation, a de novo truncating mutation (c.1971T>G [p.Tyr657*]), was identified in another affected individual. PIK3R1 is involved in the phosphatidylinositol 3 kinase (PI3K) signaling cascade and, as such, plays an important role in cell growth, proliferation, and survival. Functional studies on lymphoblastoid cells with the PIK3R1 c.1906_1907insC mutation showed decreased phosphorylation of the downstream S6 target of the PI3K-AKT-mTOR pathway. Our findings show that PIK3R1 mutations are the major cause of SHORT syndrome and suggest that the molecular mechanism of disease might involve downregulation of the PI3K-AKT-mTOR pathway. PMID:23810382

Dyment, David A; Smith, Amanda C; Alcantara, Diana; Schwartzentruber, Jeremy A; Basel-Vanagaite, Lina; Curry, Cynthia J; Temple, I Karen; Reardon, William; Mansour, Sahar; Haq, Mushfequr R; Gilbert, Rodney; Lehmann, Ordan J; Vanstone, Megan R; Beaulieu, Chandree L; Majewski, Jacek; Bulman, Dennis E; O'Driscoll, Mark; Boycott, Kym M; Innes, A Micheil

2013-06-27

36

New generation of radiacs: small computerized multipurpose radiation monitors  

SciTech Connect

The Health Division at Los Alamos has developed a multipurpose radiation monitoring device that is computer-controlled, light weight (3 lb), includes multiple radiation detectors running simultaneously, and is simple to use. This multipurpose radiac is generic in nature and can use any of the standard radiation detectors such as NaI, /sup 3/He, LET proportional gas counters, solid state surface barrier detectors, etc. LCD displays indicate the various radiation parameters in both alphanumeric and graphics format. Internal batteries allow 100 hours of use.

Umbarger, C.J.; Bjarke, G.O.; Erkkila, B.H.; Trujillo, F.; Waechter, D.A.; Wolf, M.A.

1982-01-01

37

EuroSkyWay Multipurpose Terminal: architecture and design methodology  

NASA Astrophysics Data System (ADS)

This paper describes the architecture of the EuroSkyWay Multipurpose Terminal, aimed to satisfy the need of the Provider and Gateway Terminal of the EuroSkyWay system. First, an overview of the EuroSkyWay system is shown, with a short description of the proprietary EuroSkyWay protocol layer and of the terminals. The extension of the OMT methodology that has been used to design the system is described. Then, the architecture of the Multipurpose Terminal described in terms of configurations, hardware and software.

Ciancarelli, C.; Macchia, G.

2002-07-01

38

UNDERSTANDING VIRTUAL WORLD USAGE: A MULTIPURPOSE MODEL AND EMPIRICAL TESTING  

Microsoft Academic Search

This study reports an attempt to enhance our understanding of the reasons behind virtual world usage. By providing a mixture of utilitarian and hedonic value, virtual worlds represent an emerging class of multipurpose information systems (MPIS). Previous research seems to fall short in explaining MPIS adoption, especially since key extrinsic and intrinsic motivators are not considered. Drawing upon IT adoption

Tibert Verhagen; Frans Feldberg; Bart van den Hooff; Selmar Meents

39

MULTIPURPOSE GELLING AGENT AND ITS APPLICATION TO SPILLED HAZARDOUS MATERIALS  

EPA Science Inventory

Previously, a blend of materials was formulated that would spontaneously gel a wide variety of hazardous liquids. This blend, known as the Multipurpose Gelling Agent (MGA), has been optimized to obtain a balanced formulation that will effectively gel and immobilize most spilled h...

40

Human resources for maternal health: multi-purpose or specialists?  

Microsoft Academic Search

A crucial question in the aim to attain MDG5 is whether it can be achieved faster with the scaling up of multi-purpose health workers operating in the community or with the scaling up of professional skilled birth attendants working in health facilities. Most advisers concerned with maternal mortality reduction concur to promote births in facilities with professional attendants as the

Vincent Fauveau; Della R Sherratt; Luc de Bernis

2008-01-01

41

Multi-purpose three-dimensional body form  

Microsoft Academic Search

Purpose – The purpose of this paper is to develop a multi-purpose body form that could be used to develop different types of garments by putting body skins with ease on the standard body form. Design\\/methodology\\/approach – Free form deformation method was used to generate a virtual model upon the basis of the averaged wire frame. The virtual model was

Sun Mi Park; Kueng Mi Choi; Yun Ja Nam; Young-A Lee

2011-01-01

42

A new multipurpose quality assurance phantom for clinical tomotherapy  

Microsoft Academic Search

We present a new multipurpose phantom for routine dosimetric and image quality assurance (QA) testing of a tomotherapy unit. The phantom is designed for verification of delivered dose from the intensity modulated radiation therapy (IMRT) fan beams used to provide conformal dose distributions. The phantom is used to assess imaging characteristics and verify CT number calibration for the integrated megavoltage

J. Smilowitz; J. Balog; H. Keller; G. Olivera; L. A. DeWerd; T. R. Mackie

2000-01-01

43

Breeder Spent Fuel Handling Program multipurpose cask design basis document  

SciTech Connect

The Breeder Spent Fuel Handling (BSFH) Program multipurpose cask Design Basis Document defines the performance requirements essential to the development of a legal weight truck cask to transport FFTF spent fuel from reactor to a reprocessing facility and the resultant High Level Waste (HLW) to a repository. 1 ref.

Duckett, A.J.; Sorenson, K.B.

1985-09-01

44

Real-time multipurpose reservoir operation: a case study  

Microsoft Academic Search

A real-time operational methodology has been developed for multipurpose reservoir operation for irrigation and hydropower generation with application to the Bhadra reservoir system in the state of Karnataka, India. The methodology consists of three phases of computer modelling. In the first phase, the optimal release policy for a given initial storage and inflow is determined using a stochastic dynamic programming

S. VEDULA; S. MOHAN

45

Multipurpose community telecenters for rural development in Pakistan  

Microsoft Academic Search

Purpose – The paper aims to: assess the situation of rural population in Pakistan and information facilities available to them including telecommunications, computers and public libraries; document the community information initiatives in terms of objectives, institutional framework, staff, services, use, finance, technology and lessons learned; understand challenges and opportunities regarding the establishment of multipurpose community telecenters (MCTs) in rural areas

Khalid Mahmood

2005-01-01

46

New generation of radiacs: small computerized multipurpose radiation monitors  

SciTech Connect

The Health Division at Los Alamos has developed a multipurpose radiation monitoring device that is computer-controlled, lightweight (3 lb), includes multiple radiation detectors running simultaneously, and is simple to use. LCD displays indicate the various radiation parameters in both alphanumeric and graphics format. Internal batteries allow 100 hours of use.

Umbarger, C.J.; Bjarke, G.O.; Erkkila, B.H.; Trujillo, F.; Waechter, D.A.; Wolf, M.A.

1983-02-01

47

3R tau expression modifies behavior in transgenic mice.  

PubMed

Tauopathy is a group of disorders characterized by the accumulation of hyperphosphorylated tau protein in the brain, resulting in dementia. Here, tau-related behavior was evaluated in a mouse model with brain overexpression of the shortest human tau isoform (0N3R). Two groups of animals [tau-transgenic (tau-tg) and control littermates] were tested for learning and memory at 1 and 7 months. In the Morris water maze, all mice learned the task at 1 month of age and did not learn at 7 months. In contrast, at 7 months, the tau-tg animals demonstrated better retention of the passive avoidance response compared with their control littermates, which did not learn. In the open field test, no differences were measured between transgenic and nontransgenic young mice, but significantly higher locomotion was observed in the 7-month-old tau-tg mice compared with controls. Behavior during the elevated plus maze test was the same at 1 month, but at 7 months increased entrance to the different arms was observed in the tau-tg group. Tau expression and phosphorylation levels were analyzed at 8 months. In the subcortical brain region associated with passive avoidance behavior, the tau-tg mice demonstrated increased brain tau expression coupled with reduced relative phosphorylation. In contrast, increased tau expression and phosphorylation were measured in the cerebral cortex of the tau-tg mice. In conclusion, 7-8-month-old tau-tg mice overexpressing nonmutated 0N3R human tau isoform demonstrated enhanced behavior in the passive avoidance test, paralleled by relative tau hypophosphorylation in the subcortical brain region. PMID:20544828

Shiryaev, Natalia; Jouroukhin, Yan; Gozes, Illana

2010-09-01

48

Demonstration Test of “Multi-Purpose Incinerating Melter System”  

Microsoft Academic Search

A Multi-Purpose Incinerating Melter System (MIMS) has been developed as a volume reduction technique for a wide variety of radwastes including flame retardants such as spent resin, and non-combustible materials such as concrete, glass and steel. In the MIMS, these wastes are incinerated and\\/or melted at temperatures between 1,000 and 1,500°C generated by fossil fueled burner to produce obsidian-like ingots

Hitoshi MIYAZAKI; Kenichi TANIMOTO; Hitoshi WAKUI; Kaoru OASADA; Fuyuhiko ISHIKAWA

1994-01-01

49

“TSIKADA-M-UTTH” multi-purposes satellite system  

Microsoft Academic Search

The TSK multi-purpose satellite system has been developed to replace first generation low-orbit navigation systems as well as the COSPAS-SARSAT system. The system will provide operations for both existing customers and new customers having advanced equipment. TSK is to perform the following tasks: definition of the location of an unlimited number of mobile customers in any region of the globe

V. Cheremisin; V. Kosenko; V. Zvonar; V. Chebotarev

1994-01-01

50

A Multi-Purpose Wireless Network Emulator: QOMET  

Microsoft Academic Search

Abstract In this paper we present the design and usage of the multi-purpose wireless ,network ,emulator ,that we develop, QOMET. QOMET implements a two-stage scenario-driven,approach ,to wireless ,network emulation. We give ,here the details of the ,improved model,and ,additional ,functionality that make ,it currently possible to use ,QOMET to convert ,a real- world,scenario to a ,sequence ,of network-condition descriptors for

Razvan Beuran; Junya Nakata; Takashi Okada; Lan Tien Nguyen; Yasuo Tan; Yoichi Shinoda

2008-01-01

51

Clinical performance of 'no rub' multi-purpose solutions.  

PubMed

This was a multi-site, 231-subject double-masked, bilateral crossover study to evaluate subjective comfort and satisfaction, corneal staining and lens deposits with two 'no rub' multi-purpose solutions (MPS) used with FDA Group II (alphafilcon A, SofLens 66, Bausch & Lomb) and Group IV (etafilcon A, SUREVUE, Johnson & Johnson Vision Care) soft contact lenses. Subjects used each of the two MPS, Regimen 1 (OPTI-FREE EXPRESS Multi-Purpose Disinfecting Solution No Rub Lasting Comfort Formula, Alcon Laboratories) and Regimen 2 (ReNu MultiPlus Multi-Purpose Solution, Bausch & Lomb), for 28 days. They wore the same lens type for the duration of the study and were evaluated on days 0, 14 and 28 of each treatment period. Subjective ratings of comfort and satisfaction were significantly different between regimens, with the majority of variables in favour of Regimen 1 (P < 0.05). Corneal staining was significantly greater with the Group II, Regimen 2 combination (P < 0.0001). Group IV lenses cared for with Regimen 1 had significantly less residual lysozyme on Day 28 (562 microg) than lenses cared for with Regimen 2 (1145 microg; P < 0.0001). While both products offer the convenience of a 'no rub' regimen, differences in performance should be considered when recommending these solutions to patients. PMID:16303531

Stiegemeier, Mary Jo; Cedrone, Ronald; Evans, David; Friederichs, Greg; Holle, Douglas; Jenkins, William; Lutzi, Dagmar; Roberson, Rex; Schenker, Howard; White, Eric; Zigler, Lamar

2004-06-01

52

Accelerated carbonation of cement pastes partially substituted with fluid catalytic cracking catalyst residue (FC3R)  

Microsoft Academic Search

Accelerated carbonation tests have been carried out on Portland cement pastes and pastes partially substituted with a spent fluid catalytic cracking catalyst (FC3R) to investigate possible differences between the composition of FC3R\\/cement and plain cement matrices. Cement\\/FC3R pastes have been tested by thermogravimetry and X-ray diffraction analyses. This study has revealed that the incorporation of FC3R on pastes produces a

E. Zornoza; P. Garcés; J. Monzó; M. V. Borrachero; J. Payá

2009-01-01

53

Triad Tasks, a Multipurpose Tool to Elicit Similarity Judgments: The Case of Tzotzil Maya Plant Taxonomy  

Microsoft Academic Search

The universality of multipurpose taxonomies has been widely established in folk biology. However, recent studies with nonprofessional fish experts in the United States as well as with tree experts in the Chicago area suggest that different goals can affect category organization of natural kinds. This article reports the results of a triad task study exploring specific aspects of the multipurpose

Norbert Ross; Tomás Barrientos; Alberto Esquit-Choy

2005-01-01

54

N,N-dimethylformamide: a multipurpose building block.  

PubMed

Often used as a common solvent for chemical reations and utilized widely in industry as a reagent, N,N-dimethylformamide (DMF) has played an important role in organic synthesis for a long time. Numerous highly useful articles and reviews discussing its utilizations have been published. With a focus on the performance of DMF as a multipurpose precursor for various units in numerous reactions, this Minireview summarizes recent developments in the employment of DMF in the fields of formylation, aminocarbonylation, amination, amidation, and cyanation, as well as its reaction with arynes. PMID:22930476

Ding, Shengtao; Jiao, Ning

2012-08-28

55

Deriving Optimal Refill Rules for Multi-Purpose Reservoir Operation  

Microsoft Academic Search

This paper focuses on deriving optimal refill rules for a multi-purpose reservoir, and aims to maximize utilization benefits\\u000a under the condition of flood control safety. The entire flood season is divided into multiple sub-seasons (i.e. pre-flood\\u000a season, main-flood season and post-flood season). By advancing the start of the refill period to the beginning of the post-flood\\u000a season, seasonal design flows

Xinyuan Liu; Shenglian Guo; Pan Liu; Lu Chen; Xiang Li

2011-01-01

56

Synthesis of (2 S,3 R)-3-amino-2-hydroxydecanoic acid and (3 R,4 R)-3-amino-4-hydroxyazepane from D-isoascorbic acid  

Microsoft Academic Search

Taking advantage of the high functionality of an enantiopure protected syn-2R-amino-1,3,4-triol derivative, easily available on a multigram scale from D-isoascorbic acid, several biologically active compounds have been synthesized such as the (2S,3R)-3-amino-2-hydroxydecanoic acid (AHDA), the N-terminal moiety of microginin, and the (3R,4R)-3-amino-4-hydroxyazepane, the ophiocordin and balanol core structure.

Arounarith Tuch; Michèle Sanière; Yves Le Merrer; Jean-Claude Depezay

1996-01-01

57

Multipurpose optimization models for high level waste vitrification  

SciTech Connect

Optimal Waste Loading (OWL) models have been developed as multipurpose tools for high-level waste studies for the Tank Waste Remediation Program at Hanford. Using nonlinear programming techniques, these models maximize the waste loading of the vitrified waste and optimize the glass formers composition such that the glass produced has the appropriate properties within the melter, and the resultant vitrified waste form meets the requirements for disposal. The OWL model can be used for a single waste stream or for blended streams. The models can determine optimal continuous blends or optimal discrete blends of a number of different wastes. The OWL models have been used to identify the most restrictive constraints, to evaluate prospective waste pretreatment methods, to formulate and evaluate blending strategies, and to determine the impacts of variability in the wastes. The OWL models will be used to aid in the design of frits and the maximize the waste in the glass for High-Level Waste (HLW) vitrification.

Hoza, M.

1994-08-01

58

Reactive schedule modification in multipurpose batch chemical plants  

SciTech Connect

A new scheme is described for reactive schedule modification in the face of unexpected deviations in processing times and unit availabilities of a multipurpose batch plant (MBP). Schedule modification is done using at least impact heuristic beam search which proceeds in two levels: creation of a decision tree which makes use of possible reroutings of the product that is causing a conflict, and heuristic pruning of the search space to contain the combinatorial complexity. The heuristic chooses a path among all possible reroutings for a product such that the impact of each decision on the rest of the schedule is kept as small as possible. This approach has been implemented and tested on a number of simulated deviations in a MBP case study with three products. The proposed least impact heuristic was found to perform better than the earliest finishing unit heuristic in all the cases considered.

Kanakamedala, K.B.; Reklaitis, G.V.; Venkatasubramanian, V. (Purdue Univ., West Lafayette, IN (United States). School of Chemical Engineering)

1994-01-01

59

An optical and near-infrared multipurpose instrument HONIR  

NASA Astrophysics Data System (ADS)

We have developed an optical-infrared instrument HONIR (Hiroshima Optical and Near-InfraRed camera) to be attached to the 1.5-m Kanata telescope at Higashi-Hiroshima Observatory, Hiroshima University. HONIR is a three color (one optical and two near-infrared bands among 0.5-2.4 µm) simultaneous imager and spectrograph with a polarimetry function. The field of view of the imaging mode is 10 arcmin square with a spatial sampling of 0".29. Among the planned multipurpose functions, a two color (0.5-1.0 µm and 1.15-2.40 µm) simultaneous imaging function has been installed and operated so far. The remaining functions, spectroscopy and polarimetry, and the second near-infrared band arm, are under development and will be installed in the near future.

Sakimoto, Kiyoshi; Akitaya, Hiroshi; Yamashita, Takuya; Kawabata, Koji S.; Nakaya, Hidehiko; Miyamoto, Hisashi; Harao, Tatsuya; Itoh, Ryosuke; Matsui, Risako; Moritani, Yuki; Nakashima, Asami; Ohsugi, Takashi; Sasada, Mahito; Takaki, Katsutoshi; Ueno, Issei; Ui, Takahiro; Urano, Takeshi; Yoshida, Michitoshi

2012-09-01

60

SQ3R Doesn't Work--Or Does It?  

ERIC Educational Resources Information Center

|The SQ3R method has been the backbone of textbook reading strategies for over 20 years. However, research indicates that students--even though they know how to use the technique--do not apply it because they believe it is too involved and too time consuming. Theoretically, SQ3R is a sound technique based on current knowledge about brain…

Kopfstein, Robert Wm.

61

Multipurpose Clamping Device with Electrical Connector for in Orbit Attachment of Payloads.  

National Technical Information Service (NTIS)

The Multipurpose Clamping Device (MCD), designed for in orbit positioning of payloads on the Space Station, is presented. The MCD provides a mechanical connection between the payload and a support structure. A redundant electrical connector can be integra...

W. C. Hemink H. W. T. Braakman B. C. Braam W. Teerink G. B. Mersch

1993-01-01

62

The effect of multi-purpose shopping on pricing and location strategy for grocery stores  

Microsoft Academic Search

Though it is a well-accepted fact that consumers indulge in multi-purpose shopping, most previous models of store choice assume that grocery shopping trips are single-purpose trips. This paper provides the first empirical analysis of multi-purpose shopping using data on actual shopping trips. A latent class factor analytic logit model is proposed, which provides a representation of the market structure of

Peter T. L. Popkowski Leszczyc; Ashish Sinha; Anna Sahgal

2004-01-01

63

Assessment of patient and practitioner satisfaction with Biotrue™ multi-purpose solution for contact lenses  

Microsoft Academic Search

PurposeConsumer product companies often use in-home studies to gain consumer insights on product performance. Satisfaction surveys completed in the office have been shown to overestimate satisfaction ratings. The purpose of this study was to evaluate the consumer acceptance of a novel multi-purpose solution (Bausch & Lomb Biotrue multi-purpose solution) through the use of a unique Internet survey and a measurement

William Reindel; Gerard Cairns; Mohinder Merchea

64

Development of Cyclic ?-MSH Analogues with Selective hMC3R Agonist and hMC3R/hMC5R Antagonist Activities  

PubMed Central

A series of cyclic lactam analogues of ?-MSH (H-Tyr1-Val2-Met3-Gly4-His5-Phe6-Arg7-Trp8-Asp9-Arg10-Phe11-Gly12-OH) with a bulky hydrophobic residue in the direct proximity to the pharmacophore (Xaa-d-Phe/d-Nal(2?)-Arg-Trp) were designed and synthesized by solid-phase methods. A variety of amino acids with a broad range of hydrophobic/hydrophilic properties was introduced in position 5 to further explore their complementary role in receptor selectivity. Biological evaluation of these peptides revealed several analogues with potent hMC3R agonist and hMC3R/hMC5R antagonist activities, and good receptor selectivity. Analogue 4, c[Nle-Arg-d-Phe-Arg-Trp-Glu]-NH2, was found to be a very potent and selective hMC3R agonist (EC50 = 1.2 nM, 112% act). In addition, analogue 13, c[Nle-Val-d-Nal(2?)-Arg-Trp-Glu]-NH2, was identified as an hMC3R/hMC5R antagonist with the best selectivity against the hMC4R in this series (pA2(hMC3R) = 8.4; pA2(hMC5R) = 8.7). These results indicate the significance of steric factors in melanocortin receptor selectivity and suggest that introduction of bulky residues in the direct proximity to the melanocortin pharmacophore is an effective approach to design of novel hMC3R and hMC5R selective ligands.

Mayorov, Alexander V.; Cai, Minying; Chandler, Kevin B.; Petrov, Ravil R.; Van Scoy, April R.; Yu, Zerui; Tanaka, Dustin K.; Trivedi, Dev; Hruby, Victor J.

2006-01-01

65

Chiron approach to the synthesis of (2S,3R)-3-hydroxypipecolic acid and (2R,3R)-3-hydroxy-2-hydroxymethylpiperidine from D-glucose.  

PubMed

The first chiron approach from d-glucose for the total synthesis of (2 S,3 R)-3-hydroxypipecolic acid (-)-1a and (2R,3R)-3-hydroxy-2-hydroxymethylpiperidine (-)-2a is reported. The synthetic pathway involves conversion of d-glucose into 3-azidopentodialdose (5) followed by the Wittig olefination and reduction to give the piperidine ring skeleton (8) with a sugar appendage that on cleavage of an anomeric carbon followed by oxidation gives (-)-1a which on reduction affords (-)-2a. PMID:18363367

Kalamkar, Navnath B; Kasture, Vijay M; Dhavale, Dilip D

2008-03-26

66

Human resources for maternal health: multi-purpose or specialists?  

PubMed Central

A crucial question in the aim to attain MDG5 is whether it can be achieved faster with the scaling up of multi-purpose health workers operating in the community or with the scaling up of professional skilled birth attendants working in health facilities. Most advisers concerned with maternal mortality reduction concur to promote births in facilities with professional attendants as the ultimate strategy. The evidence, however, is scarce on what it takes to progress in this path, and on the 'interim solutions' for situations where the majority of women still deliver at home. These questions are particularly relevant as we have reached the twentieth anniversary of the safe motherhood initiative without much progress made. In this paper we review the current situation of human resources for maternal health as well as the problems that they face. We propose seven key areas of work that must be addressed when planning for scaling up human resources for maternal health in light of MDG5, and finally we indicate some advances recently made in selected countries and the lessons learned from these experiences. Whilst the focus of this paper is on maternal health, it is acknowledged that the interventions to reduce maternal mortality will also contribute to significantly reducing newborn mortality. Addressing each of the seven key areas of work – recommended by the first International Forum on 'Midwifery in the Community', Tunis, December 2006 – is essential for the success of any MDG5 programme. We hypothesize that a great deal of the stagnation of maternal health programmes has been the result of confusion and careless choices in scaling up between a limited number of truly skilled birth attendants and large quantities of multi-purpose workers with short training, fewer skills, limited authority and no career pathways. We conclude from the lessons learnt that no significant progress in maternal mortality reduction can be achieved without a strong political decision to empower midwives and others with midwifery skills, and a substantial strengthening of health systems with a focus on quality of care rather than on numbers, to give them the means to respond to the challenge.

Fauveau, Vincent; Sherratt, Della R; de Bernis, Luc

2008-01-01

67

Prevalence of rare MC3R variants in obese cases and lean controls.  

PubMed

The role of mutations in the melanocortin-3 receptor (MC3R) gene, which is implicated in the regulation of energy homeostasis, is still under debate. Animal studies have clearly proven that, together with the melanocortin-4 receptor (MC4R), the MC3R is a critical receptor for melanocortin peptides within the leptin-melanocortin signaling cascade. However, as several mutations have been found in lean individuals and not all mutations seem to cause receptor dysfunction, results from mutation screens in obese humans remain controversial. In the present study, we screened for rare variants in the MC3R gene of obese children and lean controls to assess the prevalence of MC3R mutations in the Belgian population. We screened 249 severely overweight and obese children and adolescents and 239 lean adults for mutations in the coding region of MC3R. Mutation screening was performed by high resolution melting curve analysis and direct sequencing. We identified four non-synonymous coding variations in the obese population, all of which had been reported previously. In addition, we also found four novel rare MC3R variants in the lean control population, suggesting that not all MC3R mutations are disease-causing. Overall, the total prevalence of rare MC3R variants was 1 % in Belgian obese children and adolescents compared to 1.02 % in lean controls. Ultimately, cosegregation studies combined with comprehensive functional analysis is required to determine the potential pathogenic role of rare MC3R variants in causing human obesity. PMID:23264184

Zegers, Doreen; Beckers, Sigri; Hendrickx, Rik; Van Camp, Jasmijn K; Van Hoorenbeeck, Kim; Desager, Kristine N; Massa, Guy; Van Gaal, Luc F; Van Hul, Wim

2012-12-24

68

Multipurpose explosive (MPX) drum-shaped packaging design criteria  

SciTech Connect

In fiscal year 1993, the Transportation Management Division of the US Department of Energy sponsored an engineering study, completed by Westinghouse Hanford Company, to examine the viability of a generic packaging design able to satisfy multiple explosives packaging needs. Engineering study results indicated that a box-shaped and drum-shaped (allowable outer packaging shapes) multipurpose explosive (MPX) packaging would mitigate the impact of US Department of Transportation (DOT) Docket HM-181. The MPX packaging concept was for a multi-modal, reusable outer packaging to facilitate the transport of prepackaged solid explosives, most of which are in obsolete pre-HM-181 specification packagings, inside of the MPX packaging. This document sets forth the design criteria for the drum-shaped MPX packaging. These design criteria delineate minimum functional and regulation mandated requirements for the MPX drum-shaped packaging. Functional requirements are derived from US Department of Energy site personnel involved in explosives manufacturing and shipping. Regulatory requirements are derived from DOT and International Air Transport Association transport regulations, enabling the MPX packaging to be used by commercial carriers in either highway or air transportation modes.

Not Available

1994-05-01

69

A multi-purpose brain-computer interface output device.  

PubMed

While brain-computer interfaces (BCIs) are a promising alternative access pathway for individuals with severe motor impairments, many BCI systems are designed as stand-alone communication and control systems, rather than as interfaces to existing systems built for these purposes. An individual communication and control system may be powerful or flexible, but no single system can compete with the variety of options available in the commercial assistive technology (AT) market. BCls could instead be used as an interface to these existing AT devices and products, which are designed for improving access and agency of people with disabilities and are highly configurable to individual user needs. However, interfacing with each AT device and program requires significant time and effort on the part of researchers and clinicians. This work presents the Multi-Purpose BCI Output Device (MBOD), a tool to help researchers and clinicians provide BCI control of many forms of AT in a plug-and-play fashion, i.e., without the installation of drivers or software on the AT device, and a proof-of-concept of the practicality of such an approach. The MBOD was designed to meet the goals of target device compatibility, BCI input device compatibility, convenience, and intuitive command structure. The MBOD was successfully used to interface a BCI with multiple AT devices (including two wheelchair seating systems), as well as computers running Windows (XP and 7), Mac and Ubuntu Linux operating systems. PMID:22208120

Thompson, David E; Huggins, Jane E

2011-10-01

70

Monitoring microbial sulfate reduction in porous media using multipurpose electrodes  

NASA Astrophysics Data System (ADS)

There is growing interest in the application of electrode-based measurements for monitoring microbial processes in the Earth using biogeophysical methods. In this study, reactive electrode measurements were combined to electrical geophysical measurements during microbial sulfate reduction occurring in a column of silica beads saturated with natural river water. Electrodic potential (EP), self potential (SP) and complex conductivity signals were recorded using a dual electrode design (Ag/AgCl metal as sensing/EP electrode, Ag/AgCl metal in KCl gel as reference/SP electrode). Open-circuit potentials, representing the tendency for electrochemical reactions to occur on the electrode surfaces, were recorded between sensing/EP electrode and reference/SP electrode and showed significant spatiotemporal variability associated with microbial activity. The dual electrode design isolates the microbial driven sulfide reactions to the sensing electrode and permits removal of any SP signal from the EP measurement. Based on the known sensitivity of a Ag electrode to dissolved sulfide, we interpret EP signals exceeding 550 mV recorded in this experiment in terms of bisulfide (HS-) concentration near multiple sensing electrodes. Complex conductivity measurements capture an imaginary conductivity (??) signal interpreted as the response of microbial growth and biomass formation in the column. Our results suggest that the implementation of multipurpose electrodes, combining reactive measurements with electrical geophysical measurements, could improve efforts to monitor microbial processes in the Earth using electrodes.

Zhang, Chi; Ntarlagiannis, Dimitrios; Slater, Lee; Doherty, Rory

2010-09-01

71

World: A multipurpose GPS-network computer package  

NASA Astrophysics Data System (ADS)

WORLD is a multipurpose package to compute geodetic positions in geometry and gravity space. Here undifferenced GPS carrier beat phase observations are processed in the free network mode, namely by the prototype program called PUMA. Within two alternative model formulations, the classical Gauß-Markov Model and the so-called Mixed Model, simultaneously estimated / predicted parameters are those of type (i) Cartesian ground station coordinates (geodetic positioning), (ii) Cartesian satellite coordinates (orbit determination), (iii) receiver- and satellite-specific bias terms, (iv) initial epoch ambiguities and (v) proportional tropospheric corrections. The Mixed Model parameters appear from linearization as a point of stochastic prior information. Namely the weight matrices of stochastic prior information, e.g. for orbit parameters, is assumed to be known. Estimators of type BLUE and predictors of type inhom BLIP and hom BLUP are used. Chapter four discusses in all detail the real analysis of GPS satellite networks of free type. Most notable are the estimated bias terms ?, ?, ?, in a twofold classification model. The operability of PUMA is demonstrated by the use of multistation phase observations (Wild-Magnavox WM 101-receivers) in a local Berlin network (six station network). It is documented that in spite of the advanced phase observation modelling an internal relative baseline accuracy (utmost length 30 km) of the order of 3 to 5 ppm is achievable. In addition, the influence of orbital prior information on ground station measures, point position as well as accuracy, is demonstrated.

Grafarend, Erik W.; Lindlohr, Wolfgang

72

Spherical chamber effective solution for multipurpose nuclear microprobe  

NASA Astrophysics Data System (ADS)

Vacuum chambers for multipurpose nuclear microprobes must provide for the installation and servicing of several detection systems operating simultaneously, as well as sample visual control and mechanical manipulation. Detectors for X-rays, scattered ions, nuclear reaction products, secondary electrons, secondary luminescence and optical microscopes are mounted at the angles preferably larger than 120° with respect to the beam direction. Their positioning should not increase the space in the region between the ion lens and the focal point of the microprobe. Spherical chambers presented here effectively solve this problem and offer, at the same time, ports for gamma-ray detector, annular microscope, easy manual access in the sample region, ports for vertical and horizontal sample positioning and manipulation, as well as STIM and ERDA detectors at forward scattering angles and the Faraday cup. The basic construction, resulting in the three different but similar chamber designs at three nuclear microprobes worldwide, are presented. Current installation details, comments on the performance and suggested improvements are given.

Pelicon, P.; Sim?i?, J.; Jakši?, M.; Meduni?, Z.; Naab, F.; McDaniel, F. D.

2005-04-01

73

Multipurpose active pixel sensor (APS)-based microtracker  

NASA Astrophysics Data System (ADS)

A new, photon-sensitive, imaging array, the active pixel sensor (APS) has emerged as a competitor to the CCD imager for use in star and target trackers. The Jet Propulsion Laboratory (JPL) has undertaken a program to develop a new generation, highly integrated, APS-based, multipurpose tracker: the Programmable Intelligent Microtracker (PIM). The supporting hardware used in the PIM has been carefully selected to enhance the inherent advantages of the APS. Adequate computation power is included to perform star identification, star tracking, attitude determination, space docking, feature tracking, descent imaging for landing control, and target tracking capabilities. Its first version uses a JPL developed 256 X 256-pixel APS and an advanced 32-bit RISC microcontroller. By taking advantage of the unique features of the APS/microcontroller combination, the microtracker will achieve about an order-of-magnitude reduction in mass and power consumption compared to present state-of-the-art star trackers. It will also add the advantage of programmability to enable it to perform a variety of star, other celestial body, and target tracking tasks. The PIM is already proving the usefulness of its design concept for space applications. It is demonstrating the effectiveness of taking such an integrated approach in building a new generation of high performance, general purpose, tracking instruments to be applied to a large variety of future space missions.

Eisenman, Allan R.; Liebe, Carl C.; Zhu, David Q.

1998-12-01

74

Multichannel all-optical 3R regenerative wavelength conversion using an integrated semiconductor optical amplifier array  

Microsoft Academic Search

Multichannel all-optical 3R regenerative wavelength conversion at 10 Gbit\\/s is demonstrated using a novel module in a fibre interferometer. The module is a packaged, monolithically integrated, 22-channel SOA-array with 2 AWG routers.

G. Gavioli; P. Bayvel

2003-01-01

75

The ACTN3 R577X Polymorphism in East and West African Athletes  

Microsoft Academic Search

YANG, N., D. G. MACARTHUR, B. WOLDE, V. O. ONYWERA, M. K. BOIT, S. Y. M. LAU, R. H. WILSON, R. A. SCOTT, Y. P. PITSILADIS, and K. NORTH. The ACTN3 R577X Polymorphism in East and West African Athletes. Med. Sci. Sports Exerc., Vol. 39, No. 11, pp. 1985-1988, 2007. Purpose: To determine the frequency of the ACTN3 R577X polymorphism

NAN YANG; DANIEL G. MACARTHUR; BEZABHE WOLDE; VINCENT O. ONYWERA; MICHAEL K. BOIT; SAU YIN MARY-ANN LAU; RICHARD H. WILSON; ROBERT A. SCOTT; YANNIS P. PITSILADIS; KATHRYN NORTH

2007-01-01

76

Emergy evaluation perspectives of a multipurpose dam proposal in Korea.  

PubMed

The 'emergy' concept was used to evaluate the economy of Korea and the contributions of a multipurpose dam proposal to the real wealth of the Korean economy. Emergy is defined as the available energy of one kind previously used up directly and indirectly to make a product or service. The indices for Korea calculated from the emergy evaluation were close to those of developed countries. Even though its monetary balance of payments was negative in 1997, the economy of Korea showed positive balance in trade when exports and imports were expressed in emergy. The emergy evaluation showed that the Korean economy places a large stress on its environment. Water supply and generation of electricity were the most important contributions of the proposed dam in terms of emergy; 46.5 and 45.1% of the total benefit, respectively. Flood control contributed 8.4% of the total benefit. Major costs associated with the proposed dam were from sediments (33.2% of the total cost), construction services (22.8%), and social disruption of the region (21.6%). In terms of emergy, the ratio of benefits to costs of the proposed dam was 2.78 if sediments are not included, and 1.86 if sediments are included, which result in more benefits than costs in both cases. The benefit to cost ratio of the dam was larger than that of the current system (1.42) without the dam whether sediments are included in the total cost or not. The environmental stress of the proposed dam was considerably lower than that of the Korean economy, but the dam might increase stress on local environment. PMID:12448407

Kang, Daeseok; Park, Seok Soon

2002-11-01

77

A multipurpose immobilized biocatalyst with pectinase, xylanase and cellulase activities  

PubMed Central

Background The use of immobilized enzymes for catalyzing various biotransformations is now a widely used approach. In recent years, cross-linked enzyme aggregates (CLEAs) have emerged as a novel and versatile biocatalyst design. The present work deals with the preparation of a CLEA from a commercial preparation, Pectinex™ Ultra SP-L, which contains pectinase, xylanase and cellulase activities. The CLEA obtained could be used for any of the enzyme activities. The CLEA was characterized in terms of kinetic parameters, thermal stability and reusability in the context of all the three enzyme activities. Results Complete precipitation of the three enzyme activities was obtained with n-propanol. When resulting precipitates were subjected to cross-linking with 5 mM glutaraldehyde, the three activities initially present (pectinase, xylanase and cellulase) were completely retained after cross-linking. The Vmax/Km values were increased from 11, 75 and 16 to 14, 80 and 19 in case of pectinase, xylanase and cellulase activities respectively. The thermal stability was studied at 50°C, 60°C and 70°C for pectinase, xylanase and cellulase respectively. Half-lives were improved from 17, 22 and 32 minutes to 180, 82 and 91 minutes for pectinase, xylanase and cellulase respectively. All three of the enzymes in CLEA could be reused three times without any loss of activity. Conclusion A single multipurpose biocatalyst has been designed which can be used for carrying out three different and independent reactions; 1) hydrolysis of pectin, 2) hydrolysis of xylan and 3) hydrolysis of cellulose. The preparation is more stable at higher temperatures as compared to the free enzymes.

Dalal, Sohel; Sharma, Aparna; Gupta, Munishwar Nath

2007-01-01

78

Multi-purpose greenhouse of changeable geometry (MGCG)  

NASA Astrophysics Data System (ADS)

In the frames of scientific program of National Cosmic Agency of Ukraine the multipurpose greenhouse is being developed. It is destined for the performance of biological and biotechnological experiments as well as for planting of fast growing vegetable cultures for crew ration enrichment and positive psychological influence under the conditions of long-term flight in the international space station or in other cosmic flying objects. Main principle of greenhouse arrangement is the existence of unified modules. Their sets and combinations permit to form executively different space greenhouse configurations. The minimal structural greenhouse unit suitable either for construction of total configuration or for autonomous functioning, is a carrying composite platform (CCP). The experimental vegetative module (EVM) and the module, supporting microclimate needed inside EVM, are launched to CCP. The amount of these modules and their configuration depend on quantity and complexity of tasks to be solved as well as on duration of their performance. These modules form the experimental block. Four modules of much larger sizes, which form experimentally technological block, are used for further studies of objectives approved in the experimental block. The technologies developed for growing plants are used in the third, technological block, which is a one large vegetative module. All three greenhouse blocks can be changed in their sizes in three dimensions, and function either in a complete greenhouse structure, or autonomously. The control is performed from a board computer, or, if necessary, it is governed with automation devices placed on a front panel of blocks. All three blocks are pulled out along the directing base into the station passage, and this makes free access to the base modules, convenient work with them, and à good survey.

Kordium, V.; Kornejchuk, A.

79

The Application of Stretched SP(3,R) Approximation to the Rare Earth Nuclei and the Comparisons of SP(3,R) Lowest Weight States.  

NASA Astrophysics Data System (ADS)

The microscopic formulation of the Bohr Mottelson collective model using an algebraic Sp(3,R) method is applied to the nuclei ('126)Ba, ('154)Sm, ('164)Yb and ('166)Er. It is done by diagonalizing a collective hamiltonian in the stretched subspace of an Sp(3,R) irreducible shell model space. The shell model space considered includes configurations of up to 100(H/2PI)w oscillator shells. However in all cases, the results, as a function of the configurations retained, converged by 40(H/2PI)w. The rotational bands and states of the above nuclei are obtained with the correct deformation, B(E2) values and moments of inertia. Since the Sp(3,R) model, a priori, assumes that low-lying collective phenomena can be described within one Sp(3,R) irreducible representation, the important physical aspects of a calculation are contained in the choice of Sp(3,R) irreducible representation space which is in turn, defined by its lowest weight state. Thus it is of paramount importance to carefully analyze the physical basis for choosing the lowest weight state. An analysis is prescribed based on deformed harmonic oscillator, Nilsson model and Hartree-Fock considerations. The thesis is divided into two parts. The first part introduces the microscopic formulation of nuclear collective motion and descirbes the calculation in the stretched subspace as described above. The representations chosen for those calculations were based on lowest weight states obtained simply by filling the lowest single particle levels of an axially symmetric deformed harmonic oscillator of the experimental deformation. In the second part, candidates of lowest weight state are constructed using the method of PART1 combined with considerations of the more physical Nilsson hamiltonian. The energies of these lowest weight states are compared as a function of deformation in Hartree -Fock calculation using the realistic two body potential B1 of Brink and Boeker. The result is that there exist a correlation between nearness of the lowest weight state to ground state of Nilsson hamiltonian and to Hartree-Fock energy(i.e. the lower the Hartree Fock energy, the closer is the lowest weight state to the ground state of the Nilsson hamiltonian). On the strength of these results, suggestions are made for a more complete analysis.

Park, Peter Sungsoo

80

Acacia albida and other multipurpose trees on the fur farmlands in the Jebel Marra highlands, Western Darfur, Sudan  

Microsoft Academic Search

This paper describes the traditional agroforestry systems based on Acacia albida and other multipurpose trees as practised by the sedentary Fur people on the lower slopes and highlands of the Jebel Marra massif, Sudan. The basic agrosilvopastoral system consists of terraced village fields, where semipermanent rainfed cropping of staple millet and other subsistence crops takes place under stands of multipurpose

S. Miehe

1986-01-01

81

3C3R modified PBL pediatric teaching of Chinese medical students.  

PubMed

A Content, Context, Connection and Researching, Reasoning, Reflecting (3C3R) model is a conceptual framework for problem-based learning (PBL) problem design. We introduced the 3C3R-PBL method into a pediatric teaching plan, and evaluated its effectiveness and feasibility. The 3C3R model was applied in a pediatric problem design teaching plan "why the lips turn purple when a baby is crying". All students were assigned either into a traditional PBL course or into a 9-step 3C3R model PBL course (3C3R-PBL). The performance outcomes of both groups were compared. For the PBL group, the proportion of students scoring ?4 for content, context, and problem design connection, was 90.8%, 80.3%, and 64.5% respectively, while for tutors, it was 71.4%, 71.4%, and 28.6%; for researching, reasoning, and reflecting, the proportion of students scoring ?4 was 81.6%, 55.3%, and 40.8%, while for tutors, it was 71.4%, 100%, and 57.1%. The learning difficulty was not considered high with only 31.6% of students and 42.9% of tutors rating the task as difficult. For the 3C3R-PBL group, the proportion of students scoring content, context, and connection, ?4 was 100%, 98.4%, and 90.5%, while for tutors it was 100%, 100%, 83.3%; for researching, reasoning, and reflecting, the proportion of students scoring ?4 was 95.2%, 88.9%, and 76.2%, while for tutors it was 100% for all 3 R components. Students and tutors were convinced by the content, case context, research process and reasoning process of both teaching plans, while scores for connection and reflecting were significantly improved when the PBL plan was amended by a 3C3R model (p<0.05) and the case learning difficulty was statistically increased (p<0.05). The 3C3R model, evaluated for the first time in China, was helpful for effective and reliable problem design in a pediatric PBL teaching plan for Chinese students. PMID:23667610

Xue, Haihong; Qian, Jihong; Wang, Lianwen; Yuan, Xiaojun; Chen, Yi; Wu, Weilan; Chen, Yan; Sun, Kun

2013-05-07

82

Polymorphisms in MC3R promoter and CTSZ 3?UTR are associated with tuberculosis susceptibility  

PubMed Central

We have validated the association of two genes on chromosome 20q13.31–33 with tuberculosis susceptibility. A previous genome-wide linkage study performed by Cooke et al identified the genes melanocortin-3-receptor (MC3R) and cathepsin Z (CTSZ) as possible candidates in tuberculosis susceptibility. MC3R has been implicated in obesity studies and is known to play a role in many biological systems including the regulation of energy homeostasis and fat metabolism. CTSZ has been detected in immune cells, such as macrophages and monocytes, and it is hypothesized that the protein may play a role in the immune response. In our South African population a case–control study confirmed the previously reported association with a single-nucleotide polymorphism (SNP) in CTSZ and found an association in MC3R with a SNP not previously implicated in tuberculosis susceptibility. Six SNPs in MC3R and eight in CTSZ were genotyped and haplotypes were inferred. SNP rs6127698 in the promoter region of MC3R (cases=498; controls=506) and rs34069356 in the 3?UTR of CTSZ (cases=396; controls=298) both showed significant association with tuberculosis susceptibility (P=0.0004 and <0.0001, respectively), indicating that pathways involving these proteins, not previously researched in this disease, could yield novel therapies for tuberculosis.

Adams, Lindsey A; Moller, Marlo; Nebel, Almut; Schreiber, Stefan; van der Merwe, Lize; van Helden, Paul D; Hoal, Eileen G

2011-01-01

83

Pharmaceutical evaluation of multipurpose excipients for direct compressed tablet manufacture: comparisons of the capabilities of multipurpose excipients with those in general use.  

PubMed

Recently, a novel type of multipurpose excipient (MPE) with high binding characteristics and high fluidity has been developed. In this study, the capabilities of MPEs (Ludipress and Microcelac) were compared with those of excipients in general use. Also, the effects on powder and tableting characteristics of the physical properties and contents of active ingredients were examined in tablets prepared with these MPEs by the direct compression method. Multipurpose excipients mixed with adjuvants such as fillers, binders, lubricants, disintegrants, and the like show superior fluidity and compressibility. Tablets containing very small amounts of highly active ingredients with little dispersion were prepared. However, with increases in active ingredient content, each of the physical properties was affected strongly by the properties of the active ingredient. Tablets with appropriate hardness and disintegration characteristics could be prepared by mixing of different types of MPEs. PMID:10434130

Goto, K; Sunada, H; Danjo, K; Yonezawa, Y

1999-08-01

84

Comparison of ICD10 and DC: 0-3R Diagnoses in Infants, Toddlers and Preschoolers  

Microsoft Academic Search

The purpose of this study was to analyze and compare diagnoses of patients from a special outpatient department for infants,\\u000a toddlers and preschoolers. Specifically, overlap, age and gender differences according to the two classification systems DC:\\u000a 0-3R and ICD-10 were examined. 299 consecutive children aged 0–5;11 years received both ICD-10 and DC: 0-3R diagnoses. All\\u000a ICD-10 diagnoses were given prospectively at

Monika EquitFrank; Frank Paulus; Pia Fuhrmann; Justine Niemczyk; Alexander von Gontard

85

The 3R's of Solid Waste & the Population Factor for a Sustainable Planet.  

ERIC Educational Resources Information Center

|Opens with a brief history of human awareness of our effect upon the environment. Culminates with a discussion of a strategy to handle solid wastes. This plan includes the 3R's: (1) source reduction; (2) direct reuse of products; and (3) recycling. Also provides statistics on recycling practices of some countries. (ZWH)|

Wagner, Joan

1995-01-01

86

Regulatory acceptance and use of 3R models: a multilevel perspective.  

PubMed

The importance placed on risk avoidance in our society has resulted in a broad range of regulations intended to guarantee safety of products such as pharmaceuticals and chemicals. Many of these regulations rely on animal tests. As a result, about 25% of the animal experiments in Europe are done for regulatory purposes. There are many initiatives that aim to replace, reduce, or refine laboratory animal use, but the regulatory acceptance and use of 3R models lags behind. The central question of this study is: "Which variables influence the regulatory acceptance and use of 3R models and in what way?" Regulatory acceptance is seen as one of the biggest hurdles 3R models face, but the rationale behind this is still underexplored. This study is an approach to filling that gap by combining opinions from experts in the field with literature on technology acceptance and risk regulation, resulting in a model of the variables that determine the process of the regulatory acceptance and use of 3R models. PMID:22847256

Schiffelers, Marie-Jeanne W A; Blaauboer, Bas J; Hendriksen, Coenraad F M; Bakker, Wieger E

2012-01-01

87

ACTN3 R577X Polymorphism and Explosive Leg Muscle Power in Elite Basketball Players.  

PubMed

PURPOSE: The purpose of this study was to determine the association of the ACTN3 R577X polymorphism with leg muscle explosive power in Spanish (Caucasian) elite basketball players and controls. METHODS: 100 (60 men) elite basketball players (cases) and 283 non-athletic controls participated in the study. We assessed power performance by means of the vertical squat and counter-movement jump tests. RESULTS: Genotype distributions did not differ between groups (cases: 37.0% (RR), 42.0% (RX) and 21.0% (XX); controls: 31.8% (RR), 49.8% (RX) and 18.4% (XX); P=0.353). We did not observe any effect of the ACTN3 R577X polymorphism on study phenotypes in either group, including when we performed the analyses separately in men and women. We found no association between the ACTN3 R577X polymorphism and the likelihood of being an elite basketball player using the dominant or the recessive model, and the results remained unaltered when the analyses were adjusted for sex, weight, height and age or when performed for men and women separately. CONCLUSIONS: Although the ACTN3 R577X is associated with 'explosive' muscle performance and this phenotype is important in the sport of basketball (i.e. during jumps), we found no association with leg 'explosive' power in elite basket players or with the status of being such type of athlete. PMID:23689106

Garatachea, Nuria; Verde, Zoraida; Santos-Lozano, Alejandro; Yvert, Thomas; Rodriguez-Romo, Gabriel; Sarasa, Francisco J; Hernández-Sánchez, Sonsoles; Santiago, Catalina; Lucia, Alejandro

2013-05-20

88

Benefits of Student-Generated Note Packets: A Preliminary Investigation of SQ3R Implementation  

ERIC Educational Resources Information Center

Minimal research to date has evaluated the impact of Survey-Question-Read-Recite-Review (SQ3R) implementation (i.e., surveying prior to reading, generating questions, reading to answer said questions, reciting, and reviewing information) on content retention and student performance. Existing research is anecdotal or lacks ecological validity. The…

Carlston, David L.

2011-01-01

89

Comparison of ICD-10 and DC: 0-3R Diagnoses in Infants, Toddlers and Preschoolers  

ERIC Educational Resources Information Center

|The purpose of this study was to analyze and compare diagnoses of patients from a special outpatient department for infants, toddlers and preschoolers. Specifically, overlap, age and gender differences according to the two classification systems DC: 0-3R and ICD-10 were examined. 299 consecutive children aged 0-5;11 years received both ICD-10 and…

Equit, Monika; Paulus, Frank; Fuhrmann, Pia; Niemczyk, Justine; von Gontard, Alexander

2011-01-01

90

APPLICATION OF A MULTIPURPOSE UNEQUAL-PROBABILITY STREAM SURVEY IN THE MID-ATLANTIC COASTAL PLAIN  

EPA Science Inventory

A stratified random sample with unequal-probability selection was used to design a multipurpose survey of headwater streams in the Mid-Atlantic Coastal Plain. Objectives for data from the survey include unbiased estimates of regional stream conditions, and adequate coverage of un...

91

The Design and Development of an Undercover Multipurpose Anti-spoofing Kit (UnMask)  

Microsoft Academic Search

This paper describes the design and development of a software system to support law enforcement in investigating and prosecuting email based crimes. It focuses on phishing scams which use emails to trick users into revealing personal data. The system described in this paper, called the Undercover Multipurpose Anti-Spoofing Kit (UnMask), will enable investigators to reduce the time and effort needed

Sudhir Aggarwal; Jasbinder Bali; Zhenhai Duan; Leo Kermes; Wayne Liu; Shahank Sahai; Zhenghui Zhu

2007-01-01

92

CONVERSION OF JORDÃO'S THEATRE HALL INTO A MULTIPURPOSE HALL - STUDY OF ITS ACOUSTICAL PROPERTIES  

Microsoft Academic Search

The aim of the work presented on this paper is to characterize Jordão's Theatre Hall acoustical performance, in order to study the ability for its conversion into a Multipurpose Hall. This paper is based on a study of the acoustical rehabilitation of Jordão's Theatre Hall at Guimarães, Portugal. Built in 1938, this theatre (actually dismissed) is an example of the

Luís Bragança; Jorge Patrício; Bárbara Yü Belo

93

Variable Low-Frequency Absorber for Multi-Purpose Concert Halls  

Microsoft Academic Search

Multi-purpose concert halls face a dilemma. They can host classical music concerts, rock concerts and spoken word performances in a matter of a short period. These different performance types require significantly different acoustic conditions in order to provide the best sound quality to both the performers and the audience. A recommended reverberation time for classical music may be in the

Niels Werner Larsen; Eric R. Thompson

94

Engineering a Multi-Purpose Test Collection for Web Retrieval Experiments.  

ERIC Educational Resources Information Center

|Describes a test collection that was developed as a multi-purpose testbed for experiments on the Web in distributed information retrieval, hyperlink algorithms, and conventional ad hoc retrieval. Discusses inter-server connectivity, integrity of server holdings, inclusion of documents related to a wide spread of likely queries, and distribution…

Bailey, Peter; Craswell, Nick; Hawking, David

2003-01-01

95

Integrating three representation models in fuzzy multipurpose decision making based on fuzzy preference relations  

Microsoft Academic Search

The purpose of this paper is to study a fuzzy multipurpose decision making problem, where the information about the alternatives provided by the experts can be of a diverse nature. the information can be represented by means of preference orderings, utility functions and fuzzy preference relations, and our objective is to establish a general model which cover all possible representations.

F. Chiclana; F. Herrera; E. Herrera-Viedma

1998-01-01

96

Design of a battery-powered multi-purpose bipedal locomotor with parallel mechanism  

Microsoft Academic Search

This paper describes the design of a battery driven bipedal robot, which uses 6-DOF parallel mechanisms for its each leg. We have designed this considering a bipedal robot as the leg module that is sufficient for practical use as a multi-purpose locomotor of the robot system. This robot is applicable to various fields, such as medical, welfare and entertainment. In

Yusuke Sugahara; Tatsuro Endo; H. Lim; Atsuo Takanishi

2002-01-01

97

Multipurpose Intense 14 MeV Neutron Source at Bratislava: Design Study.  

National Technical Information Service (NTIS)

The present state of design of the multipurpose intense 14 MeV neutron source based on a D exp + ion beam and a metal tritide target is reported. It is essentially a 300 keV electrostatic air insulated accelerator capable to accelerate a deuterium ion bea...

J. Pivarc S. Hlavac J. Kral P. Oblozinsky I. Ribansky

1980-01-01

98

GROWTH PERFORMANCE AND NUTRIENT CONTENTS OF SOME SALT TOLERANT MULTIPURPOSE TREE SPECIES GROWING UNDER SALINE ENVIRONMENT  

Microsoft Academic Search

A field study was conducted at NIA experimental farm, Tandojam to observe the growth and nutrients (macro and micro) content of some salt tolerant multipurpose tree species (Acacia ampliceps, Acacia stenophylla, Acacia nilotica, Eucalyptus camaldulensis, and Conocarpus lancifolius) under saline environment. The salinity of the soil was varying from medium saline to very highly saline. The growth performances recorded at

M. U. SHIRAZI; M. A. KHAN; MUKHTIAR ALI; S. M. MUJTABA; S. MUMTAZ; B. KHANZADA; M. A. HALO; M. RAFIQUE; J. A. SHAH; K. A. JAFRI; N. DEPAR

99

A Multi-Purpose Math Lab: A Place for All Seasons.  

ERIC Educational Resources Information Center

|Two services offered by Bellevue Community College's Multipurpose Math Lab are described in this report. The first of these is the lab's drop-in tutorial center, which offers tutorial support, worksheets, and other instructional materials to students at all levels of mathematics course work. This section of the report describes the philosophy of…

Habib, Berthe

100

A Multi-purpose Flow System Based on Multi-commutation  

Microsoft Academic Search

A multi?purpose flow system designed with solenoid valves and micropumps is proposed. The independent control of each active device was exploited to implement dilutions, calibration with a single solution, standard additions, titrations and strategies to increase sample residence time without changing the manifold hardware. Sample dispersion coefficients between 1 and 7800 were achieved by changing the sample volume and exploiting

Fábio R. P. Rocha; Carlos M. C. Infante; Wanessa R. Melchert

2006-01-01

101

Development of a multipurpose fruit and vegetable processor for a manned mission to Mars  

Microsoft Academic Search

Current plans for long duration space missions anticipate the need for self-sustaining habitats, which would include plants for food and atmospheric reprocessing. Growth of food, in turn, necessitates a food processing element. A multipurpose fruit and vegetable processor (MFVP) was designed and built for this purpose by comparing potential technologies using equivalent system mass (ESM) impact, a NASA metric. As

D. C. Voit; M. R. Santos; R. Paul Singh

2006-01-01

102

An evaluation of multipurpose oil seed crop for industrial uses ( Jatropha curcas L.): A review  

Microsoft Academic Search

Jatropha curcas, a multipurpose, drought resistant, perennial plant belonging to Euphorbiaceae family is gaining lot of importance for the production of biodiesel. It is a tropical plant that can be grown in low to high rainfall areas either in the farms as a commercial crop or on the boundaries as a hedge to protect fields from grazing animals and to

Ashwani Kumar; Satyawati Sharma

2008-01-01

103

Evaluation of Life Sciences Glovebox (LSG) and Multi-Purpose Crew Restraint Concepts.  

National Technical Information Service (NTIS)

Within the scope of the Multi-purpose Crew Restraints for Long Duration Spaceflights project, funded by Code U, it was proposed to conduct a series of evaluations on the ground and on the KC-135 to investigate the human factors issues concerning confined/...

M. Whitmore

2005-01-01

104

KAIR (CAPPARIS DECIDUA (FORSK.) EDGEW.)—A MULTIPURPOSE WOODY SPECIES FOR ARID REGIONS  

Microsoft Academic Search

Capparis decidua (Forsk) Edgew. is an under-exploited, drought hardy, multipurpose, woody shrub or small tree found throughout arid regions of Indian sub-continent. It is of great value to the inhabitants in a variety of ways. The green immature fruits are rich in protein, carbohydrates, fats and minerals (Ca, P & Fe); immature fruits are either pickled or made into a

P. R. MEGHWAL; J. C. TEWARI

2002-01-01

105

Growth analysis of nine multipurpose woody legumes native from southern Mexico  

Microsoft Academic Search

The growth of nine multipurpose woody legumes was evaluated in nursery conditions. These species, belonging to the genera Acacia, Leucaena, Lysiloma, Prosopis and Pithecellobium, inhabit both primary and secondary tropical deciduous and thorn forests. The total length of the experiments was 165 days. At a variable frequency, the following four variables were measured: (1) relative growth rate (RGR), (2) root\\/shoot

Virginia Cervantes; Vicente Arriaga; Jorge Meave; Julia Carabias

1998-01-01

106

High-Mobility Multipurpose Wheeled Vehicle/High-Mobility Trailer (HMMWV/HMT) Brake Analysis.  

National Technical Information Service (NTIS)

The Army has a need for a companion High-Mobility Trailer (HMT) for its fleet of High-Mobility Multipurpose Wheeled Vehicles (HMMWVs). The HMT is required to have a Gross Vehicle Weight (GVW) of 3400 pounds and be equipped with either surge or service bra...

M. Alexander

1990-01-01

107

Development of a Control System for a Multipurpose Road Repairing Machine  

Microsoft Academic Search

In this paper an automatic control system for a multipurpose road pavement repairing machine (ROADMOTO) is introduced. ROADMOTO machine is equipped with asphalt milling drum and two asphalt spreaders. The old wearing course of the road is heated and milled. Asphalt spreader in the middle of the machine is used for spreading the crushed old pavement. Asphalt spreader in the

Pekka Kilpeläinen; Mika Jaakkola; Pauli Alanaatu

2009-01-01

108

Optimization for Workspace Volume of 3R Robot Manipulator Using Modified Differential Evolution  

NASA Astrophysics Data System (ADS)

Robotic manipulators with three-revolute (3R) family of positional configurations are very common in the industrial robots (IRs). The manipulator capability of a robot largely depends on the workspace (WS) of the manipulator apart from other parameters. With the constraints in mind, the optimization of the workspace is of prime importance in designing the manipulator. The workspace of manipulator is formulated as a constrained optimization problem with workspace volume as objective function. It is observed that the previous literature is confined to use of conventional soft computing algorithms only, while a new search modified algorithm is conceptualized and proposed here to improve the computational time. The proposed algorithm gives a good set of geometric parameters of manipulator within the applied constrained limits. The availability of such an algorithm for optimizing the workspace is important, especially for highly constrained environments. The efficiency of the proposed approach to optimize the workspace of 3R manipulators is exhibited through two cases.

Biswal, Bibhuti Bhusan; Panda, Sumanta; Mishra, Debadutta

109

An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia  

PubMed Central

We identify an autosomal mutation in the CSF3R gene in a family with a chronic neutrophilia. This T617N mutation energetically favors dimerization of the granulocyte colony-stimulating factor (G-CSF) receptor transmembrane domain, and thus, strongly promotes constitutive activation of the receptor and hypersensitivity to G-CSF for proliferation and differentiation, which ultimately leads to chronic neutrophilia. Mutant hematopoietic stem cells yield a myeloproliferative-like disorder in xenotransplantation and syngenic mouse bone marrow engraftment assays. The survey of 12 affected individuals during three generations indicates that only one patient had a myelodysplastic syndrome. Our data thus indicate that mutations in the CSF3R gene can be responsible for hereditary neutrophilia mimicking a myeloproliferative disorder.

Plo, Isabelle; Zhang, Yanyan; Le Couedic, Jean-Pierre; Nakatake, Mayuka; Boulet, Jean-Michel; Itaya, Miki; Smith, Steven O.; Debili, Najet; Constantinescu, Stefan N.; Louache, Fawzia; de Botton, Stephane

2009-01-01

110

An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia.  

PubMed

We identify an autosomal mutation in the CSF3R gene in a family with a chronic neutrophilia. This T617N mutation energetically favors dimerization of the granulocyte colony-stimulating factor (G-CSF) receptor transmembrane domain, and thus, strongly promotes constitutive activation of the receptor and hypersensitivity to G-CSF for proliferation and differentiation, which ultimately leads to chronic neutrophilia. Mutant hematopoietic stem cells yield a myeloproliferative-like disorder in xenotransplantation and syngenic mouse bone marrow engraftment assays. The survey of 12 affected individuals during three generations indicates that only one patient had a myelodysplastic syndrome. Our data thus indicate that mutations in the CSF3R gene can be responsible for hereditary neutrophilia mimicking a myeloproliferative disorder. PMID:19620628

Plo, Isabelle; Zhang, Yanyan; Le Couédic, Jean-Pierre; Nakatake, Mayuka; Boulet, Jean-Michel; Itaya, Miki; Smith, Steven O; Debili, Najet; Constantinescu, Stefan N; Vainchenker, William; Louache, Fawzia; de Botton, Stéphane

2009-07-20

111

Night eating and obesity in the EP3R-deficient mouse  

Microsoft Academic Search

Adult mice carrying a null mutation of the prostanoid receptor EP3R (${\\\\rm EP}3{\\\\rm R}^{-\\/-}$ mice) exhibit increased frequency of feeding during the light cycle of the day and develop an obese phenotype under a normal fat diet fed ad libitum. ${\\\\rm EP}3{\\\\rm R}^{-\\/-}$ mice show increased motor activity, which is not sufficient to offset the increased feeding leading to increased

Manuel Sanchez-Alavez; Izabella Klein; S. E. Brownell; Iustin V. Tabarean; C. N. Davis; Bruno Conti; Tamas Bartfai

2007-01-01

112

Structure of the SiC(0001)- 3 × 3 -R30° surface after initial oxidation  

Microsoft Academic Search

The structure of the 3×3-R30° reconstruction on the (0001) surface of silicon carbide before and after initial oxidation at room temperature was determined with reflection high-energy electron diffraction (RHEED) rocking curves in the one-beam condition and density-functional theory calculations. The structural parameters of the clean surface are in good agreement with previous reports. For the oxidized surface, good agreement between

Wolfgang Voegeli; Tomohiro Aoyama; Koichi Akimoto; Ayahiko Ichimiya; Yoshiyuki Hisada; Yoshihito Mitsuoka; Shinichi Mukainakano

2010-01-01

113

PIK3R1 mutations cause syndromic insulin resistance with lipoatrophy.  

PubMed

Short stature, hyperextensibility of joints and/or inguinal hernia, ocular depression, Rieger anomaly, and teething delay (SHORT) syndrome is a developmental disorder with an unknown genetic cause and hallmarks that include insulin resistance and lack of subcutaneous fat. We ascertained two unrelated individuals with SHORT syndrome, hypothesized that the observed phenotype was most likely due to de novo mutations in the same gene, and performed whole-exome sequencing in the two probands and their unaffected parents. We then confirmed our initial observations in four other subjects with SHORT syndrome from three families, as well as 14 unrelated subjects presenting with syndromic insulin resistance and/or generalized lipoatrophy associated with dysmorphic features and growth retardation. Overall, we identified in nine affected individuals from eight families de novo or inherited PIK3R1 mutations, including a mutational hotspot (c.1945C>T [p.Arg649Trp]) present in four families. PIK3R1 encodes the p85?, p55?, and p50? regulatory subunits of class IA phosphatidylinositol 3 kinases (PI3Ks), which are known to play a key role in insulin signaling. Functional data from fibroblasts derived from individuals with PIK3R1 mutations showed severe insulin resistance for both proximal and distal PI3K-dependent signaling. Our findings extend the genetic causes of severe insulin-resistance syndromes and provide important information with respect to the function of PIK3R1 in normal development and its role in human diseases, including growth delay, Rieger anomaly and other ocular affections, insulin resistance, diabetes, paucity of fat, and ovarian cysts. PMID:23810378

Thauvin-Robinet, Christel; Auclair, Martine; Duplomb, Laurence; Caron-Debarle, Martine; Avila, Magali; St-Onge, Judith; Le Merrer, Martine; Le Luyer, Bernard; Héron, Delphine; Mathieu-Dramard, Michèle; Bitoun, Pierre; Petit, Jean-Michel; Odent, Sylvie; Amiel, Jeanne; Picot, Damien; Carmignac, Virginie; Thevenon, Julien; Callier, Patrick; Laville, Martine; Reznik, Yves; Fagour, Cédric; Nunes, Marie-Laure; Capeau, Jacqueline; Lascols, Olivier; Huet, Frédéric; Faivre, Laurence; Vigouroux, Corinne; Rivière, Jean-Baptiste

2013-06-27

114

Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R  

PubMed Central

Lipocalin 24p3 is a secreted protein that can induce apoptosis in cells containing the 24p3 cell surface receptor, 24p3R. The oncoprotein BCR–ABL activates 24p3 and represses 24p3R expression. Thus, BCR–ABL+ cells synthesise and secrete 24p3, which induces apoptosis in normal 24p3R-containing cells but not in BCR–ABL+ cells. The cell signalling and transcription factor pathways by which BCR–ABL misregulates expression of 24p3 and 24p3R remain to be elucidated. Here we show that BCR–ABL upregulates 24p3 expression through activation of the JAK/STAT pathway, which culminates in binding of Stat5 to the 24p3 promoter. We find that 24p3R expression is regulated by Runx transcription factors, and that BCR–ABL induces a switch in binding from Runx3, an activator of 24p3R expression, to Runx1, a repressor of 24p3R expression, through a Ras signalling pathway. Finally, we show that repression of 24p3R by BCR–ABL is a critical feature of the mechanism by which imatinib kills BCR–ABL+ cells. Our results reveal diverse signalling/transcription pathways that regulate 24p3 and 24p3R expression in response to BCR–ABL and are directly relevant to the treatment of BCR–ABL+ disease.

Sheng, Zhi; Wang, Shu-Zong; Green, Michael R

2009-01-01

115

IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2.  

PubMed

Disrupting inositol 1,4,5-trisphosphate (IP3) receptor (IP3R)/B-cell lymphoma 2 (Bcl-2) complexes using a cell-permeable peptide (stabilized TAT-fused IP3R-derived peptide (TAT-IDP(S))) that selectively targets the BH4 domain of Bcl-2 but not that of B-cell lymphoma 2-extra large (Bcl-Xl) potentiated pro-apoptotic Ca(2+) signaling in chronic lymphocytic leukemia cells. However, the molecular mechanisms rendering cancer cells but not normal cells particularly sensitive to disrupting IP3R/Bcl-2 complexes are poorly understood. Therefore, we studied the effect of TAT-IDP(S) in a more heterogeneous Bcl-2-dependent cancer model using a set of 'primed to death' diffuse large B-cell lymphoma (DL-BCL) cell lines containing elevated Bcl-2 levels. We discovered a large heterogeneity in the apoptotic responses of these cells to TAT-IDP(S) with SU-DHL-4 being most sensitive and OCI-LY-1 being most resistant. This sensitivity strongly correlated with the ability of TAT-IDP(S) to promote IP3R-mediated Ca(2+) release. Although total IP3R-expression levels were very similar among SU-DHL-4 and OCI-LY-1, we discovered that the IP3R2-protein level was the highest for SU-DHL-4 and the lowest for OCI-LY-1. Strikingly, TAT-IDP(S)-induced Ca(2+) rise and apoptosis in the different DL-BCL cell lines strongly correlated with their IP3R2-protein level, but not with IP3R1-, IP3R3- or total IP3R-expression levels. Inhibiting or knocking down IP3R2 activity in SU-DHL-4-reduced TAT-IDP(S)-induced apoptosis, which is compatible with its ability to dissociate Bcl-2 from IP3R2 and to promote IP3-induced pro-apoptotic Ca(2+) signaling. Thus, certain chronically activated B-cell lymphoma cells are addicted to high Bcl-2 levels for their survival not only to neutralize pro-apoptotic Bcl-2-family members but also to suppress IP3R hyperactivity. In particular, cancer cells expressing high levels of IP3R2 are addicted to IP3R/Bcl-2 complex formation and disruption of these complexes using peptide tools results in pro-apoptotic Ca(2+) signaling and cell death. PMID:23681227

Akl, H; Monaco, G; La Rovere, R; Welkenhuyzen, K; Kiviluoto, S; Vervliet, T; Molgó, J; Distelhorst, C W; Missiaen, L; Mikoshiba, K; Parys, J B; De Smedt, H; Bultynck, G

2013-05-16

116

IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2  

PubMed Central

Disrupting inositol 1,4,5-trisphosphate (IP3) receptor (IP3R)/B-cell lymphoma 2 (Bcl-2) complexes using a cell-permeable peptide (stabilized TAT-fused IP3R-derived peptide (TAT-IDPS)) that selectively targets the BH4 domain of Bcl-2 but not that of B-cell lymphoma 2-extra large (Bcl-Xl) potentiated pro-apoptotic Ca2+ signaling in chronic lymphocytic leukemia cells. However, the molecular mechanisms rendering cancer cells but not normal cells particularly sensitive to disrupting IP3R/Bcl-2 complexes are poorly understood. Therefore, we studied the effect of TAT-IDPS in a more heterogeneous Bcl-2-dependent cancer model using a set of ‘primed to death' diffuse large B-cell lymphoma (DL-BCL) cell lines containing elevated Bcl-2 levels. We discovered a large heterogeneity in the apoptotic responses of these cells to TAT-IDPS with SU-DHL-4 being most sensitive and OCI-LY-1 being most resistant. This sensitivity strongly correlated with the ability of TAT-IDPS to promote IP3R-mediated Ca2+ release. Although total IP3R-expression levels were very similar among SU-DHL-4 and OCI-LY-1, we discovered that the IP3R2-protein level was the highest for SU-DHL-4 and the lowest for OCI-LY-1. Strikingly, TAT-IDPS-induced Ca2+ rise and apoptosis in the different DL-BCL cell lines strongly correlated with their IP3R2-protein level, but not with IP3R1-, IP3R3- or total IP3R-expression levels. Inhibiting or knocking down IP3R2 activity in SU-DHL-4-reduced TAT-IDPS-induced apoptosis, which is compatible with its ability to dissociate Bcl-2 from IP3R2 and to promote IP3-induced pro-apoptotic Ca2+ signaling. Thus, certain chronically activated B-cell lymphoma cells are addicted to high Bcl-2 levels for their survival not only to neutralize pro-apoptotic Bcl-2-family members but also to suppress IP3R hyperactivity. In particular, cancer cells expressing high levels of IP3R2 are addicted to IP3R/Bcl-2 complex formation and disruption of these complexes using peptide tools results in pro-apoptotic Ca2+ signaling and cell death.

Akl, H; Monaco, G; La Rovere, R; Welkenhuyzen, K; Kiviluoto, S; Vervliet, T; Molgo, J; Distelhorst, C W; Missiaen, L; Mikoshiba, K; Parys, J B; De Smedt, H; Bultynck, G

2013-01-01

117

Multipurpose Controller with EPICS integration and data logging: BPM application for ESS Bilbao  

NASA Astrophysics Data System (ADS)

This work presents a multipurpose configurable control system which can be integrated in an EPICS control network, this functionality being configured through a XML configuration file. The core of the system is the so-called Hardware Controller which is in charge of the control hardware management, the set up and communication with the EPICS network and the data storage. The reconfigurable nature of the controller is based on a single XML file, allowing any final user to easily modify and adjust the control system to any specific requirement. The selected Java development environment ensures a multiplatform operation and large versatility, even regarding the control hardware to be controlled. Specifically, this paper, focused on fast control based on a high performance FPGA, describes also an application approach for the ESS Bilbao's Beam Position Monitoring system. The implementation of the XML configuration file and the satisfactory performance outcome achieved are presented, as well as a general description of the Multipurpose Controller itself.

Arredondo, I.; del Campo, M.; Echevarria, P.; Jugo, J.; Etxebarria, V.

2013-10-01

118

Smart Aggregates: a Distributed Intelligent Multi-purpose Sensor Network (DIMSN) for Civil Structures  

Microsoft Academic Search

Early-age strength monitoring, impact detection, and structural health monitoring are important issues for concrete structures, especially concrete infrastructures such as bridges. A distributed intelligent multi-purpose sensor network (DIMSN) using innovative piezoelectric-based smart aggregates is proposed in this paper to address these important issues. The smart aggregate is fabricated by embedding a water-proofed piezoelectric patch into a small concrete block. The

Gangbing Song; Haichang Gu; Y. L. Mo

2007-01-01

119

The safety policies and practices of community multi-purpose recreation facilities  

Microsoft Academic Search

This research investigated the under-explored area of safety in multi-purpose recreation facilities (MPRFs). Facility managers and other managerial staff (key informants) from four MPRFs in Victoria, Australia participated in semi-structured interviews. Safety was considered important from Occupational Health and Safety (OH&S), business viability and legal liability perspectives but not from a health promotion or public health point of view. Most

Caroline Finch; Alex Donaldson; Mary Mahoney; Leonie Otago

2009-01-01

120

Engineering a multi-purpose test collection for Web retrieval experiments  

Microsoft Academic Search

Past research into text retrieval methods for the Web has been restricted by the lack of a test collection capable of supporting experiments which are both realistic and reproducible. The 1.69 million document WT10g collection is proposed as a multi-purpose testbed for experiments with these attributes, in distributed IR, hyperlink algorithms and conventional ad hoc retrieval.WT10g was constructed by selecting

Peter Bailey; Nick Craswell; David Hawking

2003-01-01

121

Control and experiments of a multi-purpose bipedal locomotor with parallel mechanism  

Microsoft Academic Search

This paper describes a control and a structure of a battery driven bipedal robot, WL-15(Waseda Leg-15), which has a 6-DOF parallel mechanism. WL-15 has been designed as a multi-purpose locomotion of robotic systems. This robot is controlled by the QNX real-time operating system. Using Math Works' SIMULINK and OPAL-RT's RT-LAB executed on Windows NT and QNX target systems, control software

Yusuke Sugahara; Tatsuro Endo; Hun-ok Lim; Atsuo Takanishi

2003-01-01

122

Growth of ten multipurpose tree species on acid soils in Sangmelima, Cameroon  

Microsoft Academic Search

Ten multipurpose tree species were planted both in monoculture and intercropped withArachis hypogea (groundnut) in a randomized complete block with three replications. The vigrou, biomass, nutrient content, and coppicing percentage of the trees were evaluated. Intercropping with groundnuts during the establishment phase did not affect subsequent growth and development of the species.Acacia mangium, Acacia auriculiformis, Cassia siamea, Calliandra calothyrsus andParaserianthes

B. Duguma; J. Tonye; J. Kanmegne; T. Manga; T. Enoch

1994-01-01

123

A multipurpose set of equipment for the fatigue testing of materials and structures  

NASA Astrophysics Data System (ADS)

A multipurpose set of fatigue testing equipment has been developed which has a flexible functional structure and can be easily adapted to various materials, structures, and loading conditions. The general design of the testing equipment and its principal components are examined, as are various auxiliary and support systems. Specific applications of the testing equipment in fatigue and fracture kinetic studies are discussed and illustrated by examples.

Filatov, E. Ia.; Pavlovskii, V. E.

124

A new multipurpose UV-Vis spectrometer for air quality monitoring and climatic studies  

Microsoft Academic Search

The multipurpose ultraviolet-visible (UV-Vis) remote sensing equipment SPATRAM (SPectrometer for Atmospheric TRAcers Monitoring) is a scanning spectrometer for measurement of electromagnetic radiation in the 250–950 nm spectral range. In this paper SPATRAM will be presented and new solutions will be discussed. The monochromator is based on the one installed in GASCOD (Gas Analyzer Spectrometer Correlating Optical Differences) developed during the

D. Bortoli; A. M. Silva; G. Giovanelli

2010-01-01

125

Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes  

PubMed Central

Summary The preferential in vitro interaction of the PHD finger of RAG2, a subunit of the V(D)J recombinase, with histone H3 tails simultaneously trimethylated at lysine 4 and symmetrically dimethylated at arginine 2 (H3R2me2sK4me3) predicted the existence of the previously unknown histone modification, H3R2me2s. Here, we report the in vivo identification of H3R2me2s . Consistent with the binding specificity of the RAG2 PHD finger, high levels of H3R2me2sK4me3 are found at antigen receptor gene segments ready for rearrangement. However, this double modification is much more general; it is conserved throughout eukaryotic evolution. In mouse, H3R2me2s is tightly correlated with H3K4me3 at active promoters throughout the genome. Mutational analysis in S. cerevisiae reveals that deposition of H3R2me2s requires the same Set1 complex that deposits H3K4me3. Our work suggests that H3R2me2sK4me3, not simply H3K4me3 alone, is the mark of active promoters, and that factors that recognize H3K4me3 will have their binding modulated by their preference for H3R2me2s.

Yuan, Chih-Chi; Matthews, Adam G.W.; Jin, Yi; Chen, Chang Feng; Chapman, Brad A.; Ohsumi, Toshiro K.; Glass, Karen C.; Kutateladze, Tatiana G.; Borowsky, Mark L.; Struhl, Kevin; Oettinger, Marjorie A.

2012-01-01

126

Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.  

PubMed

The preferential in vitro interaction of the PHD finger of RAG2, a subunit of the V(D)J recombinase, with histone H3 tails simultaneously trimethylated at lysine 4 and symmetrically dimethylated at arginine 2 (H3R2me2sK4me3) predicted the existence of the previously unknown histone modification H3R2me2s. Here, we report the in vivo identification of H3R2me2s . Consistent with the binding specificity of the RAG2 PHD finger, high levels of H3R2me2sK4me3 are found at antigen receptor gene segments ready for rearrangement. However, this double modification is much more general; it is conserved throughout eukaryotic evolution. In mouse, H3R2me2s is tightly correlated with H3K4me3 at active promoters throughout the genome. Mutational analysis in S. cerevisiae reveals that deposition of H3R2me2s requires the same Set1 complex that deposits H3K4me3. Our work suggests that H3R2me2sK4me3, not simply H3K4me3 alone, is the mark of active promoters and that factors that recognize H3K4me3 will have their binding modulated by their preference for H3R2me2s. PMID:22720264

Yuan, Chih-Chi; Matthews, Adam G W; Jin, Yi; Chen, Chang Feng; Chapman, Brad A; Ohsumi, Toshiro K; Glass, Karen C; Kutateladze, Tatiana G; Borowsky, Mark L; Struhl, Kevin; Oettinger, Marjorie A

2012-02-23

127

Association of the ACTN3 R577X Polymorphism in Polish Power-Orientated Athletes  

PubMed Central

Alpha-actinins are an ancient family of actin-binding proteins that play structural and regulatory roles in cytoskeletal organization. In skeletal muscle, ?-actinin-3 protein is an important structural component of the Z disc, where it anchors actin thin filaments, helping to maintain the myofibrillar array. A common nonsense polymorphism in codon 577 of the ACTN3 gene (R577X) results in ?-actinin-3 deficiency in XX homozygotes. Based on knowledge about the role of ACTN3 R557X polymorphism in skeletal muscle function, we postulated that the genetic polymorphism of ACTN3 could also improve sprint and power ability. We compared genotypic and allelic frequencies of the ACTN3 R557X polymorphism in two groups of men of the same Caucasian descent: 158 power-orientated athletes and 254 volunteers not involved in competitive sport. The genotype distribution in the group of power-oriented athletes showed significant differences (P=0.008) compared to controls. However, among the investigated subgroups of athletes, only the difference of ACTN3 R577X genotype between sprinters and controls reached statistical significance (P=0.041). The frequencies of the ACTN3 577X allele (30.69% vs. 40.35%; P=0.005) were significantly different in all athletes compared to controls. Our results support the hypothesis that the ACTN3 577XX allele may have some beneficial effect on sprint-power performance, because the ACTN3 XX genotype is significantly reduced in Polish power-oriented athletes compared to controls. This finding seems to be in agreement with previously reported case-control studies. However, ACTN3 polymorphism as a genetic marker for sport talent identification should be interpreted with great caution.

Cieszczyk, Pawel; Eider, Jerzy; Ostanek, Magdalena; Arczewska, Aleksandra; Leonska-Duniec, Agata; Sawczyn, Stanislaw; Ficek, Krzysztof; Krupecki, Krzysztof

2011-01-01

128

Thermal expansion and magnetostriction in RAl3 (R = Tm,Yb,Lu) single crystals  

NASA Astrophysics Data System (ADS)

We present temperature dependent thermal expansion and low temperature longitudinal magnetostriction measurements taken using a capacitance dilatometer [G.M. Schmiedeshoff et al., RSI, in press] in a PPMS-14 instrument for several cubic RAl3 (R = rare earth) compounds. Quantum oscillations in the magnetostriction were observed in LuAl3 and YbAl3, including few new frequences for the latter. Data on qualitative changes in TmAl3 thermal expansion in presence of the longitudinal magnetic field will be presented and discussed.

Bud'Ko, S. L.; Frederick, J.; Canfield, P. C.; Schmiedeshoff, G. M.

2007-03-01

129

Mutations in MYB3R1 and MYB3R4 cause pleiotropic developmental defects and preferential down-regulation of multiple G2/M-specific genes in Arabidopsis.  

PubMed

R1R2R3-Myb proteins represent an evolutionarily conserved class of Myb family proteins important for cell cycle regulation and differentiation in eukaryotic cells. In plants, this class of Myb proteins are believed to regulate the transcription of G2/M phase-specific genes by binding to common cis-elements, called mitosis-specific activator (MSA) elements. In Arabidopsis (Arabidopsis thaliana), MYB3R1 and MYB3R4 act as transcriptional activators and positively regulate cytokinesis by activating the transcription of KNOLLE, which encodes a cytokinesis-specific syntaxin. Here, we show that the double mutation myb3r1 myb3r4 causes pleiotropic developmental defects, some of which are due to deficiency of KNOLLE whereas other are not, suggesting that multiple target genes are involved. Consistently, microarray analysis of the double mutant revealed altered expression of many genes, among which G2/M-specific genes showed significant overrepresentation of the MSA motif and a strong tendency to be down-regulated by the double mutation. Our results demonstrate, on a genome-wide level, the importance of the MYB3R-MSA pathway for regulating G2/M-specific transcription. In addition, MYB3R1 and MYB3R4 may have diverse roles during plant development by regulating G2/M-specific genes with various functions as well as genes possibly unrelated to the cell cycle. PMID:21862669

Haga, Nozomi; Kobayashi, Kosuke; Suzuki, Takamasa; Maeo, Kenichiro; Kubo, Minoru; Ohtani, Misato; Mitsuda, Nobutaka; Demura, Taku; Nakamura, Kenzo; Jürgens, Gerd; Ito, Masaki

2011-08-23

130

(2 S,3 R)TMT- l-Tic-OH is a potent inverse agonist at the human ?-opioid receptor  

Microsoft Academic Search

We examined the pharmacologic effect of ?-methyl-2?,6?-dimethyltyrosine-l-tetrahydroisoquinoline-3-carboxylic acid ((2S,3R)TMT-l-Tic-OH) on G protein activation in membranes prepared from Chinese Hamster Ovary cells transfected with cDNA of the human ?-opioid receptor. (2S,3R)TMT-l-Tic-OH inhibited G protein activation to 58% of basal with an EC50 of 0.72 nM as determined by [35S]GTP?S binding. These findings suggest that (2S,3R)TMT-l-Tic-OH is a highly potent inverse agonist

Keiko Hosohata; Thomas H Burkey; Josua Alfaro-Lopez; Victor J Hruby; William R Roeske; Henry I. Yamamura

1999-01-01

131

Enantioselective formal synthesis of (-)-podophyllotoxin from (2S,3R)-3-arylaziridine-2-carboxylate.  

PubMed

Meyers' 4-aryl-1-tetralone-lactone and ent-Zhang's 2-diarylmethyl-4-oxobutanoate were synthesized in the formal synthesis of (-)-podophyllotoxin from (2S,3R)-3-arylaziridine-2-carboxylate, via 3,3-diarylpropanoate as a common intermediate, in an overall 42% yield through 10 steps and 31% yield through 6 steps, respectively. The key steps in the synthesis were regio- and diastereoselective ring opening with an aromatic nucleophile, samarium iodide promoted reductive C-N bond cleavage, and Stille coupling for introducing the vinyl functionality. The starting aziridine was enantioselectively prepared from 3,4,5-trimethoxybenzaldehyde by guanidinium ylide mediated asymmetric aziridination. All nitrogen components used in the reaction sequence are reusable as the starting guanidinium source. PMID:23496308

Takahashi, Masato; Suzuki, Noriyuki; Ishikawa, Tsutomu

2013-03-26

132

Thermal expansion, heat capacity and magnetostriction of RAl3 (R = Tm, Yb, Lu) single crystals  

NASA Astrophysics Data System (ADS)

We present thermal expansion and longitudinal magnetostriction data for cubic RAl3 (R = Tm, Yb, Lu) single crystals. The thermal expansion coefficient for YbAl3 is consistent with an intermediate valence of the Yb ion, whereas the data for TmAl3 show crystal electric field contributions and have strong magnetic field dependencies. de Haas-van Alphen-like oscillations were observed in the magnetostriction data of YbAl3 and LuAl3, several new extreme orbits were measured and their effective masses were estimated. Zero and 140 kOe specific heat data taken on both LuAl3 and TmAl3 for T < 200 K allow for the determination of a CEF splitting scheme for TmAl3.

Bud'Ko, S. L.; Frederick, J. C.; Mun, E. D.; Canfield, P. C.; Schmiedeshoff, G. M.

2008-01-01

133

Synthesis of 3R-CuMO2+? (M=Ga, Sc, In)  

NASA Astrophysics Data System (ADS)

Improvements have been made in the single-phase synthesis of 3R CuScO2 and CuInO2 by the metathesis reaction between CuCl and AMO2 (A=Li, Na; M=Sc, In). A new flux-assisted procedure has also been devised for the preparation of single-phase CuGaO2 at temperatures near 600°C. Oxygen insertion into CuScO2 and CuInO2 has been examined by heating samples in air to a temperature of 450°C. A single phase of composition CuInO2.67 can be produced by this method, while oxygen uptake for CuScO2 under similar conditions results in the production of CuO and Sc2O3.

Park, Sangmoon; Keszler, Douglas A.

2003-07-01

134

Restoring Natural Streamflow Variability by Modifying Multi-purpose Reservoir Operation  

NASA Astrophysics Data System (ADS)

Multi-purpose reservoirs typically provide benefits of water supply, hydroelectric power, and flood mitigation. Hydroelectric power generations generally do not consume water. However, temporal distribution of downstream flows is highly changed due to hydro-peaking effects. Associated with offstream diversion of water supplies for municipal, industrial, and agricultural requirements, natural streamflow characteristics of magnitude, duration, frequency, timing, and rate of change is significantly altered by multi-purpose reservoir operation. Natural flow regime has long been recognized a master factor for ecosystem health and biodiversity. Restoration of altered flow regime caused by multi-purpose reservoir operation is the main objective of this study. This study presents an optimization framework that modifying reservoir operation to seeking balance between human and environmental needs. The methodology presented in this study is applied to the Feitsui Reservoir, located in northern Taiwan, with main purpose of providing stable water-supply and auxiliary purpose of electricity generation and flood-peak attenuation. Reservoir releases are dominated by two decision variables, i.e., duration of water releases for each day and percentage of daily required releases within the duration. The current releasing policy of the Feitsui Reservoir releases water for water-supply and hydropower purposes during 8:00 am to 16:00 pm each day and no environmental flows releases. Although greater power generation is obtained by 100% releases distributed within 8-hour period, severe temporal alteration of streamflow is observed downstream of the reservoir. Modifying reservoir operation by relaxing these two variables and reserve certain ratio of streamflow as environmental flow to maintain downstream natural variability. The optimal reservoir releasing policy is searched by the multi-criterion decision making technique for considering reservoir performance in terms of shortage ratio and power generation and downstream hydrologic alterations in terms of ecological relevant indicators. The results show that the proposed methodology can mitigate hydro-peaking effects on natural variability, while maintains efficient reservoir operation.

Shiau, J.

2010-12-01

135

Accumulation of spatial charge in the time projection chamber of a multipurpose detector  

NASA Astrophysics Data System (ADS)

This article presents the results of a numerical simulation of the process of spatial positive charge accumulation in the Time Projection Chamber (TPC) of the multipurpose detector (MPD) at Nuclotron-based Ion Collider fAcility (NICA) at the Joint Institute for Nuclear Research (JINR). Based on the spatial distribution of the charges, the problem of calculating the potential of the electrostatic field created by these charges has been solved. The radial, angular, and axial distortions in the electron motions from the point of ionization to the readout planes are calculated.

Merts, S. P.; Razin, S. V.; Rogachevskii, O. V.

2013-01-01

136

Neutronics analysis of the proposed 25-MW leu TRIGA Multipurpose Research Reactor  

SciTech Connect

More than two years ago the government of Indonesia announced plans to purchase a research reactor for the Puspiptek Research Center in Serpong Indonesia to be used for isotope production, materials testing, neutron physics measurements, and reactor operator training. Reactors using low-enriched uranium (LEU) plate-type and rod-type fuel elements were considered. This paper deals with the neutronic evaluation of the rod-type 25-MW LEU TRIGA Multipurpose Research Reactor (MPRR) proposed by the General Atomic Company of the United States of America.

Nurdin, M.; Bretscher, M.M.; Snelgrove, J.L.

1982-01-01

137

Indian multipurpose food and low-fat groundnut flour as supplements for school children  

Microsoft Academic Search

Summary  \\u000a \\u000a \\u000a \\u000a 1. \\u000a \\u000a A feeding experiment extending over a period of 5 months was carried out on 96 boys aged 5–12 years who were resident in a\\u000a boarding school. The purpose of the study was to assess the value of supplementing their diets with 2 oz. daily of Indian\\u000a Multipurpose Food (composed of groundnut flour and Bengal gram) or with 1.7

B. R. H. Rao; V. Benjamin; G. Jesudian; Mary E. Dumm

1965-01-01

138

Superexchange interaction revisited for orthorhombic perovskite manganites RMnO3 (R=rare earth)  

NASA Astrophysics Data System (ADS)

The manganese perovskite oxides RMnO3 ( R= rare-earth element) show the strong interplay between charge, orbital, lattice, and spin degrees of freedom. Depending on rare-earth ions, their magnetic ground state varies from the A-type to E-type antiferromagnetism (AFM) through the spiral ordering and accordingly Mn-O-Mn bonding angles and local octahedral deformations are changed. Moreover, the ferroelectric properties emerge in the case of spiral or E-type RMnO3. In this study, we have studied the magnetic superexchange interaction in RMnO3 based on the microscopic model incorporating the GdFeO3-type octahedral tilting and the Jahn-Teller (JT) distortion. We have found that (i) the account of t2g electrons is essential to describe both the nearest-neighbor (NN) and next-nearest-neighbor (NNN) superexchange interactions, (ii) the JT distortion angle as well as the octahedral tilting and the JT distortion strength is an important factor for the superexchange interactions, and (iii) two NNN interactions in the ab plane are anisotropic but are both antiferromagnetic. We have determined the magnetic-phase diagram of RMnO3 and discussed the magnetic ground states in relation to the experiments.

Kim, Beom Hyun; Min, B. I.

2010-03-01

139

Cylindrical crystals of molybdenite-3R:sem- and x-ray investigations  

NASA Astrophysics Data System (ADS)

Flat faces are the characteristic feature of ionic crystals; nevertheless, among them there are cleavage-faced ones, up to the crystals with cylindrical shapes. More often they occur among minerals with layer structure or minerals with higher tendency to structural defectiveness (cylindrite, franckeite, asbestos, jamesonite, boulangerite and etc.). We studied exotic cylindrical crystals of molybdenite, discovered in the pegmatite veins of Slyudyanogorsky deposit of muscovite in Middle Ural by Kobyashev Yu. S., Zverev G. F. in 1973. Crystals have cylindrical shape, sometimes with sharpened or flattened wedge-shaped edges. Their length is 2-10 mm, diameter 0.8-mm. At the cross section crystals possess concentrically-laminar composition with tabulated axled canal with diameter about 120mkm. Thin layers arise packages about 15 mkm thickness. In the section crystals are fixed up to 6 such packages visually as well as by methods of X-ray phase-dispersed introscopy. According to the data of monocrystal and powder X-ray molybdenite represents as trigonal polytype 3R-R3m with insignificant quantity of hexagonal polytype 2H-P6@3/mmc. Twisting of leaf-like crystalline germs is one of the reasons of formation of cylindrical crystals due to syngenetic shistosity of containing rocks with crystallization.

Yushkin, N.; Zhabin, A.

2003-04-01

140

Yeast retrotransposon Ty4: the majority of the rare transcripts lack a U3-R sequence.  

PubMed Central

The retrotransposon Ty4 is found in different yeast strains at only one to three copies per haploid genome. In the present study, we aimed at relating the apparent low transpositional activity of Ty4 to transcriptional features of this element. RT-PCR revealed that Ty4 is transcribed at a very low level, being comparable with that of GAL4. Contrary to other Ty elements, the transcriptional rate of Ty4 is not affected in a sin4 background nor by treatment of cells with alpha factor. From experiments measuring the expression levels in 1acZ fusion constructs, we conclude that Ty4 transcription is repressed by a negative regulating element residing within the LTR, whereas positive cis-acting elements, like those that have been found to mediate expression of Ty1/2 and Ty3, are absent from Ty4. Analysing Ty4 transcript termini by the RACE-PCR method, we found several distinct transcriptional initiation sites. But surprisingly, the majority of the polyadenylated Ty4 transcripts terminate shortly upstream from the 3' LTR boundary, so that these transcripts do not contain a U3-R sequence, which is normally required for obligate strand transfer during DNA synthesis. Thus, the extremely low transcription rate of Ty4 and imperfect Ty4 transcripts are the reason for the low transpositional activity of this element.

Hug, A M; Feldmann, H

1996-01-01

141

Higher frequency of the ACTN3 R allele + ACE DD genotype in Japanese elite wrestlers.  

PubMed

In this study, the authors investigated the association between the ACTN3 and angiotensin-converting enzyme (ACE) genotypes and the performance of 135 Japanese elite male wrestlers. Fifty-two wrestlers had participated in world championships, including the Olympic Games, or had placed first in Japanese national championships and were classified as "international." The remaining 83 wrestlers were classified as "national." The control group consisted of 333 healthy Japanese college students majoring in physical education. In the ACTN3 genotype distribution, a significant difference between the international and control groups was observed (p < 0.05). The ACE genotype distribution and allele frequency of all wrestlers significantly differed from those of the control subjects (p < 0.001). As compared with the control group, the odds ratio of the ACTN3 R allele + ACE DD genotype being international or national was 3.85 (95% confidence interval [CI], 2.10-7.03) or 1.37 (95% CI, 0.79-2.36), respectively. Our data suggest that the combination of ACTN3 and ACE gene polymorphisms is associated with the athletic status of Japanese elite wrestlers. PMID:22996021

Kikuchi, Naoki; Min, Seok-ki; Ueda, Dai; Igawa, Shoji; Nakazato, Koichi

2012-12-01

142

(2R,3R)-3-O-Benzoyl-N-benzyl-tartramide1  

PubMed Central

The title compound, C18H17NO6 [systematic name: (2R,3R)-4-benzyl­amino-2-benzo­yloxy-3-hy­droxy-4-oxobutanoic acid], is the first structurally characterized unsymmetrical monoamide–monoacyl tartaric acid derivative. The mol­ecule shows a staggered conformation around the tartramide Csp3—Csp3 bond with trans-oriented carboxyl and amide groups. The mol­ecular conformation is stabilized by an intra­molecular N—H?O hydrogen bond. In the crystal, mol­ecules are linked by O—H?O hydrogen bonds between the carboxyl and amide carbonyl groups, forming translational chains along [001]. Further O—H?O and N—H?O hydrogen bonds as well as weaker C—H?O and C—H?? inter­molecular inter­actions extend the supra­molecular assembly into a double-layer structure parallel to (100). There are no directional inter­actions between the double layers.

Madura, Izabela D.; Zachara, Janusz; Bernas, Urszula; Hajmowicz, Halina; Synoradzki, Ludwik

2012-01-01

143

Emergence of the multiferroic state in RMnO3 (R = Sm and Nd) crystals  

NASA Astrophysics Data System (ADS)

In order to understand the emergence of multiferroic behaviour in the RMnO3 compounds, it is educational to study the relationship between ferroelectricity and magnetoelastically induced lattice modulations. Lattice modulations in RMnO3 are strongly dependent on the Mn-O-Mn bond angle (?), which in turn is determined by the ionic radii (rR) of the R atoms. Multiferroic properties have been observed in the orthorhombic RMnO3 (R = Tb,Dy) compounds, in which ? is close to 145 . In order to induce multiferroic behaviour in other magnetic members of the orthorhombic RMnO3, and to tune the structure to be in the same region of the phase diagram as Tb/DyMnO3, it is necessary to substitute at the R site with a suitable (smaller) atom. We have achieved this in SmMnO3 and NdMnO3 by substitutions at the Sm and Nd sites with smaller R ions. In the optimally substituted compounds (40 to 50%), we observe an additional magnetic transition. Investigations of the dielectric properties of the crystals reveal anomalies in the dielectric properties coincident with this magnetic transition, analogous to those exhibited by Tb/DyMnO3, indicative of multiferroic behaviour. We present detailed investigations of the magnetic, dielectric and structural properties in single crystals of selected compositions.

Balakrishnan, G.; O'Flynn, D.; Tomy, C. V.; Lees, M. R.

2009-03-01

144

Development of ultrananocrystalline diamond (UNCD) coatings for multipurpose mechanical pump seals.  

SciTech Connect

The reliability and performance of silicon carbide (SiC) shaft seals on multipurpose mechanical pumps are improved by applying a protective coating of ultrananocrystalline diamond (UNCD). UNCD exhibits extreme hardness (97 GPa), low friction (0.1 in air) and outstanding chemical resistance. Consequently, the application of UNCD coatings to multipurpose mechanical pump seals can reduce frictional energy losses and eliminate the downtime and hazardous emissions from seal failure and leakage. In this study, UNCD films were prepared by microwave plasma chemical vapor deposition utilizing an argon/methane gas mixture. Prior to coating, the SiC seals were subjected to mechanical polishing using different grades of micron-sized diamond powder to produce different starting surfaces with well-controlled surface roughnesses. Following this roughening process, the seals were seeded by mechanical abrasion with diamond nanopowder, and subsequently coated with UNCD. The coated seals were subjected to dynamic wear testing performed at 3600 RPM and 100 psi for up to 10 days during which the seals were periodically removed and inspected. The UNCD-coated seals were examined using Raman microanalysis, scanning electron microscopy, optical profilometry, and adhesion testing before and after the wear testing. These analyses revealed that delamination of the UNCD films was prevented when the initial SiC seal surface had an initial roughness >0.1 {micro}m. In addition, the UNCD surfaces showed no measurable wear as compared to approximately 0.2 {micro}m of wear for the untreated SiC surfaces.

Kovalchenko, A. M.; Elam, J. W.; Erdemir, A.; Carlisle, J. A.; Auciello, O.; Libera, J. A.; Pellin, M. J.; Gruen, D. M.; Hryn, J. N. (Materials Science Division); (Georgia Inst. of Tech.)

2011-01-01

145

Attenuated Pik3r1 Expression Prevents Insulin Resistance and Adipose Tissue Macrophage Accumulation in Diet-Induced Obese Mice  

PubMed Central

Obese white adipose tissue (AT) is characterized by large-scale infiltration of proinflammatory macrophages, in parallel with systemic insulin resistance; however, the cellular stimulus that initiates this signaling cascade and chemokine release is still unknown. The objective of this study was to determine the role of the phosphoinositide 3-kinase (PI3K) regulatory subunits on AT macrophage (ATM) infiltration in obesity. Here, we find that the Pik3r1 regulatory subunits (i.e., p85?/p55?/p50?) are highly induced in AT from high-fat diet–fed obese mice, concurrent with insulin resistance. Global heterozygous deletion of the Pik3r1 regulatory subunits (?HZ), but not knockout of Pik3r2 (p85?), preserves whole-body, AT, and skeletal muscle insulin sensitivity, despite severe obesity. Moreover, ATM accumulation, proinflammatory gene expression, and ex vivo chemokine secretion in obese ?HZ mice are markedly reduced despite endoplasmic reticulum (ER) stress, hypoxia, adipocyte hypertrophy, and Jun NH2-terminal kinase activation. Furthermore, bone marrow transplant studies reveal that these improvements in obese ?HZ mice are independent of reduced Pik3r1 expression in the hematopoietic compartment. Taken together, these studies demonstrate that Pik3r1 expression plays a critical role in mediating AT insulin sensitivity and, more so, suggest that reduced PI3K activity is a key step in the initiation and propagation of the inflammatory response in obese AT.

McCurdy, Carrie E.; Schenk, Simon; Holliday, Michael J.; Philp, Andrew; Houck, Julie A.; Patsouris, David; MacLean, Paul S.; Majka, Susan M.; Klemm, Dwight J.; Friedman, Jacob E.

2012-01-01

146

Dielectric anomaly at Néel point in antiferromagnetic RCrO 3 (R: La, Nd)  

NASA Astrophysics Data System (ADS)

Recently, we have found that antiferromagnetic RCrO3 (R: La, Nd) of perovskite type oxide shows anomaly of its dielectric property at Néel point (T_N). Similar phenomenon has been reported for several magnetic materials such as YMnO_3. The physical mechanism, however, has not been understood in the present stage. In this study, we have tried to control the lattice strain and the spin configuration of the RCrO3 by means of multilayered thin film systems. Based on the temperature dependence of the magnetization ( M-T) and the dielectric constant (\\varepsilon_r-T) for those systems, relationship between the magnetic properties and the dielectric properties are discussed. Samples were prepared by a pulsed laser deposition technique. The substrates were Nb doped SrTiO3 (100). The \\varepsilon_r-T of LaCrO3 shows drastic decrease near 280 K. The temperature is close to its TN found in M-T measurement. We have considered that the decrease of the \\varepsilonr is caused by the spin ordering below the T_N. Because the long range ordering of the spin configuration (superexchange interaction) limits the bond length and the bond angle of the Cr^3+-O^2--Cr ^3+ in the LaCrO_3, the ion displacemnet by application of electric field will be suppressed. We report the results for various strained and exhcange coupled multilayered systems from the viewpoint of the influence of the superexchange interaction to the ion displacement.

Kubota, Tetsuro; Nishikawa, Hiroaki; Hontsu, Shigeki; Kawai, Tomoji

2002-03-01

147

Trainer's Guide; Personal Computer (PC) Version of the Basic Rifle Markmanship Program for the Multipurpose Arcade Combat Simulator (MACS).  

National Technical Information Service (NTIS)

The Multipurpose Arcade Combat Simulator (MACS) system is a low-cost, part-task weapons trainer that has been validated as a teaching device with entry-level soldiers. The system may be used for preparatory, basic, sustainment, and remedial training. The ...

E. W. Wiley J. W. Purvis

1990-01-01

148

Multipurpose Transportation, Aging, and Disposal Canisters for Used Nuclear Fuel - Getting From Here to There and Beyond  

Microsoft Academic Search

The idea of a universal canister system, in which used fuel can be placed at reactor sites, transported and - without ever needing to be re-opened -, disposed of in a geologic repository, is certainly not new. Originally proposed by DOE in the early 1990's as the Multi-Purpose Canister (MPC) system, this common sense idea has always had considerable appeal

Rod McCullum

2008-01-01

149

The safety attitudes of people who use multi-purpose recreation facilities as a physical activity setting  

Microsoft Academic Search

Multi-purpose recreation facilities (MPRFs) are a popular setting for physical activity and it is therefore important that they are safe for all patrons. However, the attitudes of MPRF users towards safety are a potential barrier to the success of injury prevention programmes implemented within MPRFs. This article reports a survey of the safety attitudes of over 700 users of four

Caroline F. Finch; Leonie Otago; Peta White; Alex Donaldson; Mary Mahoney

2011-01-01

150

The Use of Antarctic, Multi-Purpose (Mp-1) Fuel in Space Heaters, Camp Stoves, and Lanterns.  

National Technical Information Service (NTIS)

The specifications for a multi-purpose fuel, MP-1 (MIL-F-23188) have been developed by the Bureau of Naval Weapons. This fuel, proposed for use at Antarctica in aircraft turbines, diesel engines, and space heaters, has received prior approval for use in C...

W. W. Watson J. J. Wise

1965-01-01

151

PRODUCTION OF FERTILIZER IN A MULTIPURPOSE ATOMIC POWER REACTOR COMPLEX FOR DISTILLATION OF SEA WATER: A SURVEY  

Microsoft Academic Search

4 = e to determine the feasibility of producing large amounts ; of nitrogen, phosphate, and potassium fertilizers with the cheap power produced ; from a large atomic reactor. The optimum combination was a multipurpose plant to ; produce fresh water from sea water by distillation and fertilizer from the air, ; sea, and phosphate rock. No other raw materials

1963-01-01

152

Orion Multi-Purpose Crew Vehicle Active Thermal Control and Environmental Control and Life Support Development Status.  

National Technical Information Service (NTIS)

The Orion Multi-Purpose Crew Vehicle (MPCV) is the first crew transport vehicle to be developed by the National Aeronautics and Space Administration (NASA) in the last thirty years. Orion is currently being developed to transport the crew safely beyond Ea...

C. D. Cross G. E. Rains J. F. Lewis R. A. Barido

2013-01-01

153

Paclitaxel accelerates spontaneous calcium oscillations in cardiomyocytes by interacting with NCS-1 and the InsP3R  

PubMed Central

Paclitaxel (Taxol) is a microtubule-stabilizing compound that is used for cancer chemotherapy. However, Taxol administration is limited by serious side effects including cardiac arrhythmia, which cannot be explained by its microtubule-stabilizing effect. Recently, neuronal calcium sensor 1 (NCS-1), a calcium binding protein that modulates the inositol-1,4,5-trisphosphate receptor (InsP3R), was described as a binding partner of Taxol and as a substrate of calpain. We examined calcium signaling processes in cardiomyocytes after treatment with Taxol to investigate the basis of Taxol-induced cardiac arrhythmia. After treating isolated neonatal rat ventricular myocytes with a therapeutic concentration of Taxol for several hours live cell imaging experiments showed that the frequency of spontaneous calcium oscillations significantly increased. This effect was not mimicked by other tubulin-stabilizing agents. However, it was prevented by inhibiting the InsP3R. Taxol treated cells had increased expression of NCS-1, an effect also detectable after Taxol administration in vivo. Short hairpin RNA mediated knock down of NCS-1 decreased InsP3R dependent intracellular calcium release, whereas Taxol treatment, that increased NCS-1 levels, increased InsP3R dependent calcium release. The effects of Taxol were ryanodine receptor independent. At the single channel level Taxol and NCS-1 mediated an increase in InsP3R activity. Calpain activity was not affected by Taxol in cardiomyocytes suggesting a calpain independent signaling pathway. In short, our study shows that Taxol impacts calcium signaling and calcium oscillations in cardiomyocytes through NCS-1 and the InsP3R.

Zhang, Kun; Heidrich, Felix M.; DeGray, Brenda; Boehmerle, Wolfgang; Ehrlich, Barbara E.

2010-01-01

154

Design and Development of Multi-Purpose CCD Camera System with Thermoelectric Cooling: Hardware  

NASA Astrophysics Data System (ADS)

We designed and developed a multi-purpose CCD camera system for three kinds of CCDs; KAF-0401E(768×512), KAF-1602E(1536×1024), KAF-3200E(2184×1472) made by KODAK Co.. The system supports fast USB port as well as parallel port for data I/O and control signal. The packing is based on two stage circuit boards for size reduction and contains built-in filter wheel. Basic hardware components include clock pattern circuit, A/D conversion circuit, CCD data flow control circuit, and CCD temperature control unit. The CCD temperature can be controlled with accuracy of approximately 0.4° C in the max. range of temperature, ? 33° C. This CCD camera system has with readout noise 6 e^{-}, and system gain 5 e^{-}/ADU. A total of 10 CCD camera systems were produced and our tests show that all of them show passable performance.

Kang, Y.-W.; Byun, Y. I.; Rhee, J. H.; Oh, S. H.; Kim, D. K.

2007-12-01

155

Source test of the prototype neutron detector for the large-acceptance multipurpose spectrometer at RAON  

NASA Astrophysics Data System (ADS)

A neutron detector array will be essential for the study of the nuclear symmetry energy in the large-acceptance multipurpose spectrometer (LAMPS) at the planned rare-isotope beam facility RAON in Korea. We have built the prototype neutron detector for LAMPS and examined its performance by using radiation sources. For data taking, we tested the voltage-threshold discriminator (VTD) and the constant-fraction discriminator (CFD) modules for the pulse process. The intrinsic time resolution of the prototype detector is estimated to be 723 ps for VTD and 488 ps for CFD. The fission neutrons and gammas emitted from 252Cf can be clearly separated in the time distribution. We reconstruct the energy spectrum of the spontaneous fission neutrons from 252Cf, which can be described well by using the empirical Watt spectrum.

Lee, Kisoo; Lee, Kyong Sei; Mulilo, Benard; Hong, Byungsik

2013-05-01

156

An Interactive Approach to Selection and Use of Single Multipurpose Reservoir Models  

NASA Astrophysics Data System (ADS)

Use of mathematical models in water resource management has been plagued in the past by the lack of communication, understanding, and involvement of managers in the model development. Interactive modeling methods give managers an appropriate role in model use, calibration, and verification. This paper extends the idea of interactive reservoir modeling using the intelligent decision support system approach. An advisory tool developed using this approach integrates formal reservoir models with reservoir expertise for making both numerical and logical inferences. This integration required special treatment, programming skills, and representations. This tool is intended to help a user to select and use the proper formal model(s) for single multipurpose reservoir analysis. The use of the tool may improve the accuracy and effectiveness of information available to managers, decision makers, and researchers. A practical example of the Gruza reservoir study demonstrates the benefits of implementing the approach.

Savic, Dragan A.; Simonovic, Slobodan P.

1991-10-01

157

Aquatic toxicity of the decontamination agent: Multipurpose (DAM) decontamination solution. Final report, May-December 1992  

SciTech Connect

A new formulation, Decontaminating Agent: Multipurpose (DAM) Decontamination Solution, is being considered as a replacement to the DS-2 decontaminating solution. The new formulation is composed of calcium hypochlorite and N-cyclohexyl-2-pyrrolidinone. Since this is a new formulation little environmental data exists. To estimate potential impact to an aquatic environment, Daphnia magna and Photobacterium phosphoreum (a luminescent marine bacterium) were exposed to the DAM solution and to the individual components (Calcium hypochlorite and N-cyclohexyl-2-pyrrolidinone). The toxicity of the DAM solution to D. magna and P. phosphoreum was 5000 and 0.00053, respectively (highly toxic). The toxicity of calcium hypochlorite' and N-cyclohexyl-2-pyrrolidinone to daphnia was 0.04 mg/L (highly toxic) and 107 mg/L (moderately toxic), respectively.

Haley, M.V.; Kurnas, C.W.; Chester, N.A.; Muse, W.T.

1994-05-01

158

Vacuum excavation, hydraulics combined by consumers power in a do-everything multi-purpose vehicle  

SciTech Connect

A multi-purpose maintenance vehicle is described that is productive, efficient, mobile, flexible and economical. Three such vehicles are currently in operation in the Consumers Power system in Michigan. Some advantages are listed and include: only a twoman crew required; vehicles equipped for all types of repair and maintenance operations; safer because there is no moving boom; inconvenience to public/pedestrians/vehicles are minimized; and shoring is eliminated. Several tasks are listed which may be performed by the vehicle: cast iron pipe bell joint repair; leak clamp applications; service line abandonments; service line renewals; anode, test wire, and bond wire installations; curb box and valve box cleaning; and checking for and venting leaks.

Hale, D.

1985-11-01

159

Bond strengths of Scotchbond Multi-Purpose to moist dentin and enamel.  

PubMed

This in vitro study tested the shear bond strengths of the Scotchbond Multi-Purpose adhesive system to moist and dry enamel and dentin. After the tooth was etched, the surface was either dried with compressed air or blotted with tissue paper, leaving the surface visibly moist. Primer and adhesive were applied according to the manufacturer's directions. Resin composite posts were applied, and the specimens were thermocycled. Shear bond strengths were determined using an Instron universal testing machine. For both enamel and dentin, mean shear bond strengths were higher when the surface was left visibly moist after etching. Bond strengths to moist and dry dentin were 21.8 and 17.8 MPa, respectively. Enamel bond strengths were slightly lower, with values of 17.0 and 14.2 MPa to moist and dry enamel, respectively. PMID:1304180

Swift, E J; Triolo, P T

1992-12-01

160

A new magnetorheological fluid damper for high-mobility multipurpose wheeled vehicle (HMMWV)  

NASA Astrophysics Data System (ADS)

Theoretical and experimental studies are performed for the design, development and testing of a new fail-safe semiactive magneto-rheological fluid (MRF) damper for a high-mobility multi-purpose wheeled vehicle (HMMWV). A fail-safe MRF damper is referred to as a device, which retains a minimum damping capacity required in the event of a power supply or electronic system failure. The proposed MRF damper is designed using a disk shape magneto-rheological (MR) valve. The MR valve occurs in the space between two fixed parallel disks with radial flow. Bingham plastic fluid model and a three-dimensional finite element electro-magentic analysis are employed to theoretically analyze the proposed MRF damper. Experimental and theoretical results are presented for force-displacement and force-time behavior of the damper under different harmonic input motion and various input magnetic fields.

Dogruer, Umit; Gordaninejad, Faramarz; Evrensel, Cahit A.

2003-07-01

161

Multipurpose Small Size Fast Reactor: Its Basic Concept and Application to Nuclear Hydrogen Production  

SciTech Connect

Here we propose a basic concept of a multipurpose small-sized fast reactor and its applicability to produce nuclear hydrogen for near future mass use of hydrogen industrial and public use. The modular-type fast reactor of 150 MW thermal output does not require fuel exchange nor decommissioning on the site, and can be transported from the factory in a fabricated form. For the hydrogen production, we propose to use the sorption enhanced reforming process (SERP), in which the steam-methane reforming can take place around 450 - 550. Since this temperature range is rather low compared to the ongoing steam reforming method (> 800 ), the SERP system combined with an adequate nuclear reactor system should be a promising one to cope with the coming age of hydrogen civilization. (authors)

Endo, H. [Toshiba Corporation (Japan); Sawada, T.; Ninokata, H. [Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8550 (Japan)

2002-07-01

162

Development of an ion beam probe for the Korea Multipurpose Accelerator Complex(KOMAC)  

NASA Astrophysics Data System (ADS)

Korea Atomic Energy Research Institute(KAERI) has been developing a multipurpose proton accelerator with energy of 1 GeV and current of 20 mA. Applied Plasma Laboratory is developing an ion beam probe measuring the magnitude and position of ion current. Using four magnetic probes we can measure the magnitude and position of pulsing ion current. Initial measurement is analyzed for an ion beam simulator, which is composed of an off-centered straight wire installed in a rotating wheel. Analytic results are given from the voltage signals measured by four magnetic probes with 0.8 mH. Improvement and a method for the DC proton beam will be addressed.

Jung, Yong-Ho; Choi, Yong-Sup; Jung, Suk-Won; Chung, Kyu-Sun; Cho, Yong-Sup; Choi, Byung-Ho

2000-10-01

163

Multiphasic responses of cerebellar Purkinje cells to 1S,3R-ACPD: an in vivo study.  

PubMed

The effects of iontophoretically applied (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), an agonist of metabotropic glutamate receptors, were examined in rat cerebellar Purkinje cells in vivo. Multibarrel electrodes were used for extracellular recordings of spontaneous single unit discharges and iontophoretic ejection of 1S,3R-ACPD. The effect of 1S,3R-ACPD depended on both the strength and the duration of the iontophoretic current. Application of the agonist with ejection currents at or slightly above the response threshold for up to 60 s resulted in an increased rate of action potential firing. With larger ejection currents of the same duration the initial increase in activity was followed by a depression and eventually a cessation of activity. In the transition phase between low frequency firing and firing arrest, Purkinje cells generated almost exclusively complex spikes. When the drug application was continued for longer durations (1-10 min) the initial response was followed by a characteristic cyclic firing pattern. These cycles consisted of alternating phases of mainly simple spike activity, predominantly complex spike activity and silent intervals. At the end of drug applications using large ejection currents, a prolonged period (on average 66 s) with almost no spiking activity was observed. This period ended with an abrupt onset of simple spike firing. These findings point to an important function of cerebellar metabotropic glutamate receptors in the regulation of Purkinje cell activity. PMID:8127470

Lingenhöhl, K; Knöpfel, T; Olpe, H R

1993-12-01

164

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells  

PubMed Central

Glioblastoma multiforme (GBM) is a highly invasive and deadly brain tumor. Tumor cell invasion makes complete surgical resection impossible and reduces the efficacy of other therapies. Genome-wide analyses of mutations, copy-number changes, and expression patterns have provided new insights into genetic abnormalities common in GBM. We analyzed published data and identified the invasion and motility pathways most frequently altered in GBM. These were most notably the focal adhesion and integrin signaling, and extracellular matrix interactions pathways. We mapped alterations in each of these pathways and found that they included the catalytic PIK3CA and regulatory PIK3R1 subunit genes of the class IA PI3K. Knockdown of either of these genes separately in GBM cell lines by lentiviral-mediated shRNA expression resulted in decreased proliferation, migration, and invasion in all lines tested. FAK activity was reduced by knockdown of either PIK3CA or PIK3R1, and MMP2 levels were reduced by knockdown of PIK3R1. We conclude that PIK3R1, like PIK3CA, is a potential therapeutic target in GBM and that it also influences tumor cell growth and motility.

Weber, Genevieve L.; Parat, Marie-Odile; Binder, Zev A.; Gallia, Gary L.; Riggins, Gregory J.

2011-01-01

165

ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players.  

PubMed

We examined the association of R577X polymorphism (rs1815739) in the ?-actinin-3 (ACTN3) gene with "explosive" leg muscle power performance in a group of male and female elite volleyball players (n=66, 31 men, 35 women) and in a group of non-athletic male and female young adults (n=334, 243 men, 91 women). We assessed power performance by means of the vertical squat and counter-movement jump tests. We also determined whether the genotypic frequencies of the ACTN3 R577X genotypes differed between groups. We did not observe any effect of the ACTN3 R577X polymorphism on study phenotypes in both groups, regardless of gender (all P>0.05). Genotype frequencies were similar between volleyball and control groups (P=0.095). Moreover, we did not find an association between the ACTN3 R577X polymorphism and the likelihood of being an elite volleyball player using the dominant (RR vs RX+XX) and the recessive model (RR+RX vs XX). In summary, these findings suggest that the ACTN3 R577X polymorphism does not influence explosive leg muscle power in elite volleyball players. PMID:20561285

Ruiz, J R; Fernández del Valle, M; Verde, Z; Díez-Vega, I; Santiago, C; Yvert, T; Rodríguez-Romo, G; Gómez-Gallego, F; Molina, J J; Lucia, A

2010-06-18

166

On a Pulkova Catalogue of 11506 AGK3R Stars in the Declination Zone from +25DEG to +90DEG  

NASA Astrophysics Data System (ADS)

A new reduction of AGK3R stars declinations as obtained from Pulkovo meridian observations has been made. The final Pulkovo catalogue of ? and ? in the FK4 system is in the data bank of the computer EC-1033 of the Pulkovo Observatory and can be also obtained from the Institute of Scientific and Technical Information (VINITI).

Baturina, G. D.; Varina, V. A.; Zverev, M. S.

1987-09-01

167

Mitigating hydrologic alterations caused by hydropeaking through modified releasing rules for a multi-purpose reservoir  

NASA Astrophysics Data System (ADS)

Hydropeaking caused by peak-load hydroelectric power production associated with other purposes releases from reservoirs significantly alter natural streamflow variability below dams at multi-temporal scales. Altered natural flow regime induced by reservoir operation is believed to threaten ecosystem biodiversity and deteriorate riverine health. Thus, securing balance between economic rewards of reservoir operation and mitigation of anthropogenic regulations of streamflow becomes a challenge task of water-resources management. In this study, environmental flow release is incorporated into a multi-purpose reservoir operation (domestic water-supply, hydroelectric power production, and flood-peak attenuation) to mitigate altered hydrologic alterations. A two-stage releasing rules for domestic demand and peak-load hydroelectric power generation associated with preservation of a fixed percentage of streamflow as environmental flow are proposed in this study. Since the releasing rules are parameterized by decision variables, an optimization framework is developed to search the optimal outcome that simultaneously considers human and environmental needs. A multi-criterion genetic algorithm is adopted in this study that contains multi-purpose reservoir performance indices (water shortage ratio and duration, annual hydroelectric power generation, and maximum flood-peak attenuation) and multi-temporal hydrologic indices (hourly-, daily-, monthly-, annual-, and interannual variation) to seek the optimal reservoir releasing policy. The methodology is applied in the Feitsui Reservoir system which is located in northern Taiwan. The results reveal that the proposed methodology can efficiently mitigate hydropeaking as well as other hydrologic alterations, but a cost of slight deterioration of reservoir performance.

Shiau, J.

2011-12-01

168

Loss of IP3R-Dependent Ca2+ Increases in Hippocampal Astrocytes Does Not Affect Baseline CA1 Pyramidal Neuron Synaptic Activity  

PubMed Central

Astrocytes in the hippocampus release calcium (Ca2+) from intracellular stores intrinsically and in response to activation of Gq-linked G-protein coupled receptors (GPCRs) through the binding of inositol 1,4,5-trisphosphate (IP3) to its receptor (IP3R). Astrocyte Ca2+ has been deemed necessary and sufficient to trigger the release of gliotransmitters, such as ATP and glutamate, from astrocytes to modulate neuronal activity. Several lines of evidence suggest that IP3R Type 2 (IP3R2) is the primary IP3R expressed by astrocytes. In order to determine if IP3R2 is the primary functional IP3R responsible for astrocytic Ca2+ increases, we conducted experiments using an IP3R2 knockout mouse model (IP3R2 KO). We show for the first time that lack of IP3R2 blocks both spontaneous and Gq-linked GPCR mediated increases in astrocyte Ca2+. Furthermore, neuronal Gq-linked GPCR Ca2+ increases remain intact, suggesting that IP3R2 does not play a major functional role in neuronal calcium store release or may not be expressed in neurons. Additionally, we show that lack of IP3R2 in the hippocampus does not affect baseline excitatory neuronal synaptic activity as measured by spontaneous EPSC (sEPSC) recordings from CA1 pyramidal neurons. Whole cell recordings of the tonic NMDA receptor (NMDA-R) mediated current indicates that ambient glutamate levels are also unaffected in the IP3R2 KO. These data show that IP3R2 is the key functional IP3R driving Gq-linked GPCR mediated Ca2+ increases in hippocampal astrocytes and that removal of astrocyte Ca2+ increases does not significantly affect excitatory neuronal synaptic activity or ambient glutamate levels.

Petravicz, J; Fiacco, TA; McCarthy, KD

2009-01-01

169

Senior Center Studies and Program Evaluations: Outcomes of the Challenge Grants Initiative of the National Eldercare Institute on Multipurpose Senior Centers and Community Focal Points.  

National Technical Information Service (NTIS)

This publication provides an overview of the results of nine studies and program evaluations conducted during the second and third years of the National Eldercare Institute on Multipurpose Senior Centers and Community Focal Points. The primary objective o...

1995-01-01

170

Synthesis and characterization of (4S)-1-chloroalkylsilatrane-4-carboxylic acids; cruytal structures of (3R,4S)-1-chloromethyl-3-methylsilatrane-4-carboxylic acid and (3R,4S)-1-(3-chloropropyl)-3-methylsilatrane-4-carboxylic acid  

Microsoft Academic Search

(4S)-1-(chloromethyl)silatrane-4-carboxylic acid 1 and (3R,4S)-1-chloromethyl-3-methylsilatrane-4-carboxylic acid 2 were synthesized by the transesterification of chlormethyltriethoxysilane with l-N,N-bis(2-hydroxyenthyl)serine or l-N,N-bis(2-hydroxyethy)threonine in teh presence of pyridine. (4S)-1-(3-chloropropyl)silatrane-4-caroxylic acid 3 and (3R,4S)-1-(3-chloropropyl)-3-methylsilstrane-4-carboxylic acid 4 were similarly synthesized from the reaction of 3-chloropropyltrimethoxysilane with the chiral ligands. The compounds were characterized by elemental analyses, IR spectra, 1H and 13C NMR spectra and mass spectra. The

Zheng-Rong Lu; Ren-Xi Zhuo; Liao-Rong Shen; Xiao-Dong Zhang; Lian-Fang Shen

1995-01-01

171

The impact of rhetoric and reality on community anticipation of risk in the development of multi-purpose services: a grounded theory study  

Microsoft Academic Search

Aims The rhetoric of multi-purpose services involves the integration of aged care facilities and other health services (usually hospitals) in small, rural communities while enhancing responsiveness to community needs. This research focused on the main concerns of participants involved in the development of multi-purpose services in rural NSW. Method Using a constructivist grounded theory methodology 30 in-depth interviews were conducted

Judith Anderson; John Grootjans; Ann Bonner

172

(2 S ,3 R )-2-Aminododecan-3-ol, a New Antifungal Agent from the Ascidian Clavelina o blonga  

Microsoft Academic Search

A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 Ìg\\/ mL and against

Miriam H. Kossuga; John B. MacMillan; Evan W. Rogers; Tadeusz F. Molinski; Gislene G. F. Nascimento; Rosana M. Rocha; Roberto G. S. Berlinck

2004-01-01

173

PHONON DEPENDENCE ON THERMAL PROPERTIES OF RGaO3(R = La, Ce, Nd, Pr, Sm, Gd)  

NASA Astrophysics Data System (ADS)

We have systematically investigated the effect of phonons on elastic, thermal and cohesive properties for rare earth gallates RGaO3(R = La, Ce, Nd, Pr, Sm, Gd) by means of a Rigid Ion Model after modifying its framework to incorporate the van der Waals interactions. Besides that, we have calculated the temperature dependence of the specific heat for the present orthogallates. The results on bulk modulus, Debye temperature and specific heat reproduce well with the available experimental data.

Parveen, Atahar; Gaur, N. K.

2012-03-01

174

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.  

PubMed

Novel quaternary ammonium derivatives of N,N-disubstituted (3R)-quinuclidinyl carbamates have been identified as potent M(3) muscarinic antagonists with long duration of action in an in vivo model of bronchoconstriction. These compounds have also presented a high level of metabolic transformation (human liver microsomes). The synthesis, structure-activity relationships and biological evaluation of these compounds are reported. PMID:21524581

Prat, Maria; Buil, María Antonia; Fernández, Maria Dolors; Castro, Jordi; Monleón, Juan Manuel; Tort, Laia; Casals, Gaspar; Ferrer, Manuel; Huerta, Josep Maria; Espinosa, Sònia; López, Manuel; Segarra, Victor; Gavaldà, Amadeu; Miralpeix, Montserrat; Ramos, Israel; Vilella, Dolors; González, Marisa; Córdoba, Mònica; Cárdenas, Alvaro; Antón, Francisca; Beleta, Jorge; Ryder, Hamish

2011-04-03

175

The structure and dielectrics of epitaxially strained BaRO3(R=Ti, Zr) thin films  

Microsoft Academic Search

The structure and static dielectric permittivity of BaRO3(R=Ti, Zr) thin films as a function of epitaxial strain are determined by using first-principle density functional theory calculation based on pseudopotentials and a plane-wave basis. It is found that BaTiO3 thin films under compressive misfit strain can be grown more easily than those under tensile misfit strain, while thin films of BaZrO3

Jinlong Tang; Jun Zhu; Jie Xiong; Wenfeng Qin; Yanrong Li

2008-01-01

176

Strong localization across the metal-insulator transition at the Ag/Si(111)-(?3 × ?3)R30° interface  

NASA Astrophysics Data System (ADS)

We present the temperature dependent electrical transport measurements of Ag/Si(111)-(?3 × ?3)R30° by the in situ micro-four-point probe method integrated with scanning tunneling microscopy. The surface structure characterizations show hexagonal patterns at room temperature, which supports the inequivalent triangle (IET) model. A metal-insulator transition occurs at ˜115 K.The lowtemperature transportmeasurements clearly reveal the strong localization characteristics of the insulating phase.

Tang, Yuan-Yuan; Guo, Jian-Dong

2013-02-01

177

New General Continuous-Time State?Task Network Formulation for Short-Term Scheduling of Multipurpose Batch Plants  

Microsoft Academic Search

A new continuous time MILP model for the short-term scheduling of multipurpose batch plants is presented. The proposed model relies on the State Task Network (STN) and addresses the general problem of batch scheduling, accounting for resource (utility) constraints, variable batch sizes and processing times, various storage policies (UIS\\/FIS\\/NIS\\/ZW), batch mixing\\/splitting, and sequence- dependent changeover times. The key features of

Christos T. Maravelias; Ignacio E. Grossmann

2003-01-01

178

A new continuous-time state task network formulation for short term scheduling of multipurpose batch plants  

Microsoft Academic Search

A new continuous-time MILP model for the short-term scheduling of multipurpose batch plants is presented. The proposed model relies on the idea of the State Task Network (STN) and addresses the general problem of batch scheduling, accounting for resources other than equipment (utilities), variable batch sizes and processing times, various storage policies (UIS\\/FIS\\/NIS\\/ZW) and batch splitting\\/mixing. Compared to other general

Christos T. Maravelias; Ignacio E. Grossmann

2003-01-01

179

Ameliorative Effect of Multipurpose Tree Species Grown on Sodic Soils of Indo-Gangetic Alluvial Plains of India  

Microsoft Academic Search

A Long-term field study was carried out to compare the impact of ten-year old plantation of ten multipurpose tree species, viz., Terminalia arjuna, Azadirachta indica, Prosopis juliflora, Pongamia pinnata, Casuarina equisetifolia, Prosopis alba, Acacia nilotica, Eucalyptus tereticornis, Pithecellobium dulce, and Cassia siamea on tree growth, biomass yield, and physico-chemical properties of sodic soils representing major tract of salt-affected soils of

Y. P. Singh; Gurbachan Singh; D. K. Sharma

2011-01-01

180

Biomass and bio-energy production of ten multipurpose tree species planted in sodic soils of indo-gangetic plains  

Microsoft Academic Search

Ten multipurpose tree species, Terminalia arjuna, Azadirechta indica, Prosopis juliflora, Pongamia pinnata, Casuarina equisetifolia, Prosopis alba, Acacia\\u000a nilotica, Eucalyptus tereticornis, Pithecellobium dulce and Cassia siamea, were raised in a monoculture tree cropping system on the sodic soil of Gangetic alluvium in north India (26° 47? N: 80°46?\\u000a E) for 10 years to evaluate the biomass and bio-energy production. The soil

Y. P. Singh; Gurbachan Singh; D. K. Sharma

2010-01-01

181

The Inositol 1,4,5-Trisphosphate Receptor (IP3R) and Its Regulators: Sometimes Good and Sometimes Bad Teamwork  

NSDL National Science Digital Library

Changes in the amount of calcium inside cells initiate many cellular events, including muscle contraction, hormone secretion, and cell growth. These changes can be modulated in time and space by the cell to tailor its response to the prevailing conditions. A major pathway used for the release of calcium from intracellular stores involves opening the inositol 1,4,5-trisphosphate receptor (IP3R), a calcium channel that is part of a signaling complex with multiple binding partners. This Review, which contains 2 tables, 6 figures, and 119 references, discusses the role of specific binding partners in regulating the function of the IP3R. These studies provide information on how these channels work and form the background for the investigation of disease-induced changes in calcium release channel function. The initiation of intracellular calcium signals can depend on factors as diverse as the nonuniform distribution of a binding partner in the lumen of the endoplasmic reticulum or the activation of a calcium-binding protein in the cytoplasm. Once calcium signals start, they can be transient, sustained, or oscillating; these temporal aspects of the signal are regulated by similarly diverse factors. Changes in intracellular calcium regulation occur in many diseases. As more and more new regulators of the IP3R are discovered, it will be important to understand the teamwork needed to regulate and modulate this complex system.

Chi-un Choe (Yale University;Departments of Pharmacology and Cellular and Molecular Physiology REV); Barbara E. Ehrlich (Yale University;Departments of Pharmacology and Cellular and Molecular Physiology REV)

2006-11-28

182

Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization.  

PubMed Central

We have isolated cDNA clones encoding an inositol 1,4,5-trisphosphate receptor type 1 (InsP3R1) from human uteri and a leukaemic cell line, HL-60. Northern-blot analysis showed that approx. 10 kb of InsP3R1 mRNA is expressed in human uteri, oviducts and HL-60 cells. The predicted amino acid sequence of human InsP3R1 (2695 amino acids) has 99% identity with that of the mouse SI-/SII- splicing counterpart. Western-blot analysis with anti-(mouse InsP3R1) antibodies showed that InsP3R1 protein of human uteri and oviducts of approx 220 kDa is immunostained. Northern-blot analysis of HL-60 cell differentiation along the neutrophilic lineage induced by retinoic acid or dimethylsulphoxide showed an accompanying enhanced expression of InsP3R1 mRNA. Immunohistochemical analysis of the cerebella of spinocerebellar degeneration patients showed a variable loss of Purkinje cells with an altered pattern of immunostaining. The InsP3R1 gene (Insp3r1) was localized to the 3P25-26 region of human chromosome 3. The data presented here clearly show that InsP3R1 exists widely in human tissues and may play critical roles in various kinds of cellular functions. Images Figure 2 Figure 3 Figure 5 Figure 6 Figure 7 Figure 8

Yamada, N; Makino, Y; Clark, R A; Pearson, D W; Mattei, M G; Guenet, J L; Ohama, E; Fujino, I; Miyawaki, A; Furuichi, T

1994-01-01

183

Development of the Carbon Cycle Column Radiometer (C3R) for ASCENDS CO and CH4 Measurements  

NASA Astrophysics Data System (ADS)

This poster describes the development of a new passive remote sensor, the Carbon Cycle Column Radiometer (C3R), for measuring CO and CH4 column abundance in support of the ASCENDS NRC Decadal Survey mission. In order to understand sources and sinks of CO2, as well as the carbon cycle in general, measurements of CO and CH4 are required with high sensitivity in the planetary boundary layer. No passive sensor concept has demonstrated, through either analysis or actual measurement, the ability to sense CO or CH4 to the spatial and temporal quality demanded by the ASCENDS mission. To meet the ASCENDS requirements, we are developing a non-conventional gas filter correlation radiometer (GFCR), the C3R, which will provide high sensitivity all the way to the surface. C3R allows these measurements to be made for a very small footprint (~250 m dia.) concentric with ASCENDS laser observations of CO2. Dominated by reflected sunlight, nadir measurements in the 2.3 µm region have relatively constant sensitivity with altitude, thus offering sensitivity in the important planetary boundary layer, the primary source region of these gases. Measurement challenges at 2.3 µm include: (1) high surface albedo variability (2) CO and CH4 bands overlapping with water vapor (H2O) and each other; and (3) a weak CO band (~100 times weaker than its fundamental mid-IR band). The C3R instrument differs from a conventional GFCR in three primary ways: (1) the use of a focal plane array (FPA) detector in a non-imaging configuration which allows photon noise-limited detection, field of view scrambling and signal flat-fielding; (2) long-path correlation cells improve sensitivity throughout the atmosphere, including high sensitivity in the boundary layer; and (3) removal of interfering gas and spectral albedo effects by a novel technique. The poster will illustrate the optomechanical design (shown in Figure 1) and current state of hardware development, instrument performance modeling results, and plans for continuing development and testing of the instrument. Figure 1. Optical/physical design of the C3R sensor prototype.

Diskin, G. S.; Crawford, J. H.; Sachse, G. W.; Gordley, L. L.; Burton, J.; McHugh, M. J.

2010-12-01

184

A multipurpose solid-phase method for protein determination with Coomassie brilliant blue G-250.  

PubMed

The multipurpose method for protein determination (MMPD) is based in the Coomassie brilliant blue G-250 binding to immobilized and washed proteins in paper filter disks, and the A600 measurement of the eluted protein-dye complexes. The analysis requires 5-microliters samples, put in 7-mm paper filter disks, which can be stored for up to 2 weeks, without sensible changes in their protein content. The A600 is a logarithmic function of the log of bovine serum albumin quantity, between 2.5 and 250 micrograms with two linear segments used as standard curves: one between 2.5 to 20 micrograms and the other between 20 and 80 micrograms. Results with the MMPD were quantitatively comparable with those obtained with the method of Lowry et al., and those reported by other workers, assaying the following material: (i) bovine serum albumin, in doubly distilled water or in presence of several substances that interfere with the current methods; and (ii) total homogenates and their respective trichloroacetic acid-insoluble extracts, which were obtained from several phenol-rich vegetal specimens and complex animal products. The MMPD is proposed as an alternative for protein determination for its versatility and reliability, in both vegetal or animal products, especially when the analysis with traditional methods is made difficult by the presence of natural or added interfering substances and the sample volume is too small to discard them, or when the material must be stored for relatively long periods of time, prior to its processing. PMID:1706563

Said-Fernández, S; González-Garza, M T; Mata-Cárdenas, B D; Navarro-Marmolejo, L

1990-11-15

185

A Design and Development of Multi-Purpose CCD Camera System with Thermoelectric Cooling: Software  

NASA Astrophysics Data System (ADS)

We present a software which we developed for the multi-purpose CCD camera. This software can be used on the all 3 types of CCD - KAF-0401E (768×512), KAF-1602E (15367times;1024), KAF-3200E (2184×1472) made in KODAK Co.. For the efficient CCD camera control, the software is operated with two independent processes of the CCD control program and the temperature/shutter operation program. This software is designed to fully automatic operation as well as manually operation under LINUX system, and is controled by LINUX user signal procedure. We plan to use this software for all sky survey system and also night sky monitoring and sky observation. As our results, the read-out time of each CCD are about 15sec, 64sec, 134sec for KAF-0401E, KAF-1602E, KAF-3200E., because these time are limited by the data transmission speed of parallel port. For larger format CCD, the data transmission is required more high speed. we are considering this control software to one using USB port for high speed data transmission.

Oh, S. H.; Kang, Y. W.; Byun, Y. I.

2007-12-01

186

A compact light-weighted and multi-purpose calibration unit for LINC-NIRVANA  

NASA Astrophysics Data System (ADS)

Laboratory and on-sky experience suggests that the integration of big astronomical instruments, specially of a complex interferometric system, is a challenging process. LINC-NIRVANA is the Fizeau interferometric imager for the Large Binocular Telescope (LBT). Simulating the final operating environment of every system component has shown how critical is the presence of flexures, vibrations and thermal expansion. Assembling and aligning the opto-mechanical sub-systems will require an absolute reference which is not affected by static displacements or positioning errors. A multi-purpose calibration unit has been designed to ensure the quality of the alignment of optics and detectors and the reliability of the mechanical setup. This new compact and light-weighted unit is characterized by sophisticated kinematics, simple mechanical design and composite materials. In addition, the reduced number of motorized axis improves the stiffness and lowers the angular displacements due to moving parts. The modular concept integrates several light sources to provide the proper calibration reference for the different sub-systems of LINC-NIRVANA. For the standard alignment of the optics an absolute reference fiber will be used. For flatfielding of the detectors the unit provides an integrating sphere, and a special rotating multi-fiber plate (infrared and visible) is used to calibrate the advanced adaptive optics and the fringe-tracking systems. A module to control non-common path aberrations (Flattening of Deformable Mirrors) is also provided.

de Bonis, Fulvio; Bertram, Thomas; Labadie, Lucas; Egner, Sebastian; Bizenberger, Peter; Hofferbert, Ralph; Eckart, Andreas; Kuerster, Martin; Herbst, Tom

2010-07-01

187

Development of JSTAMP-Works/NV and HYSTAMP for Multipurpose Multistage Sheet Metal Forming Simulation  

SciTech Connect

Since 1996, Japan Research Institute Limited (JRI) has been providing a sheet metal forming simulation system called JSTAMP-Works packaged the FEM solvers of LS-DYNA and JOH/NIKE, which might be the first multistage system at that time and has been enjoying good reputation among users in Japan. To match the recent needs, 'faster, more accurate and easier', of process designers and CAE engineers, a new metal forming simulation system JSTAMP-Works/NV is developed. The JSTAMP-Works/NV packaged the automatic healing function of CAD and had much more new capabilities such as prediction of 3D trimming lines for flanging or hemming, remote control of solver execution for multi-stage forming processes and shape evaluation between FEM and CAD.On the other way, a multi-stage multi-purpose inverse FEM solver HYSTAMP is developed and will be soon put into market, which is approved to be very fast, quite accurate and robust.Lastly, authors will give some application examples of user defined ductile damage subroutine in LS-DYNA for the estimation of material failure and springback in metal forming simulation.

Umezu, Yasuyoshi; Watanabe, Yuko; Ma, Ninshu [Japan Research Institute, Ltd. (Japan)

2005-08-05

188

Study of development and utilization of a multipurpose atmospheric corrosion sensor  

NASA Astrophysics Data System (ADS)

There has been a critical need for analyzing various aspects of atmospheric corrosion and for the development of atmospheric corrosion microsensors. The project work has involved the following activities: (1) making of multielectrode corrosion monitors on dielectric substrates; (2) testing them in the laboratory for functional characteristics; (3) preparing a report on the state of the art of atmospheric corrosion sensor development around the world; and (4) corrosion testing of electrochemical changes of sensor specimens and related fog testing. The study included work on the subject of development and utilization of a multipurpose atmospheric corrosion sensor and this report is the annual report on work carried out on this research project. This has included studies on the development of sensors of two designs, stage 1 and stage 2, and with glass and alumina substrate, experimentation and development and characterization of the coating uniformity, aspects of corrosion monitoring, literature search on the corrosion sensors and their development. A state of the art report on atmospheric corrosion sensor development was prepared and submitted.

Diwan, Ravinder M.; Raman, A.; Bhattacharya, P. K.

1994-12-01

189

DISMANTLING OF THE UPPER RPV COMPONENTS OF THE KARLSRUHE MULTI-PURPOSE RESEARCH REACTOR (MZFR), GERMANY  

SciTech Connect

The Multi-purpose Research Reactor was a pressurized-water reactor cooled and moderated with heavy water. It was built from 1961 to 1966 and went critical for the first time on 29 September 1965. After nineteen years of successful operation, the reactor was de-activated on 3 May 1984. The reactor had a thermal output of 200 MW and an electrical output of 50 MW. The MZFR not only served to supply electrical power, but also as a test bed for: - research into various materials for reactor building (e. g. zirkaloy), - the manufacturing and operating industry to gain experience in erection and operation, - training scientific and technical reactor staff, and - power supply (first nuclear combined-heat-and-power system, 1979-1984). The experience gained in operating the MZFR was very helpful for the development and operation of power reactors. At first, safe containment and enclosure of the plant was planned, but then it was decided to dismantle the plant completely, step by step, in view o f the clear advantages of this approach. The decommissioning concept for the complete elimination of the plant down to a green-field site provides for eight steps. A separate decommissioning license is required for each step. As part of the dismantling, about 72,000 Mg [metric tons] of concrete and 7,200 Mg of metal (400 Mg RPV) must be removed. About 700 Mg of concrete (500 Mg biological shield) and 1300 Mg of metal must be classified as radioactive waste.

Prechtl, E.; Suessdorf, W.

2003-02-27

190

INITIAL WASTE PACKAGE PROBABILISTIC CRITICALITY ANALYSIS: MULTI-PURPOSE CANISTER WITH DISPOSAL CONTAINER (TBV)  

SciTech Connect

This analysis is prepared by the Mined Geologic Disposal System (MGDS) Waste Package Development Department (WPDD) to provide an assessment of the present waste package design from a criticality risk standpoint. The specific objectives of this initial analysis are to: (1) Establish a process for determining the probability of waste package criticality as a function of time (in terms of a cumulative distribution function, probability distribution function, or expected number of criticalities in a specified time interval) for various waste package concepts; (2) Demonstrate the established process by estimating the probability of criticality as a function of time since emplacement for an intact multi-purpose canister waste package (MPC-WP) configuration; (3) Identify the dominant sequences leading to waste package criticality for subsequent detailed analysis. The purpose of this analysis is to document and demonstrate the developed process as it has been applied to the MPC-WP. This revision is performed to correct deficiencies in the previous revision and provide further detail on the calculations performed. This analysis is similar to that performed for the uncanistered fuel waste package (UCF-WP, B00000000-01717-2200-00079).

J.R. Massari

1995-10-06

191

Development of JSTAMP-Works/NV and HYSTAMP for Multipurpose Multistage Sheet Metal Forming Simulation  

NASA Astrophysics Data System (ADS)

Since 1996, Japan Research Institute Limited (JRI) has been providing a sheet metal forming simulation system called JSTAMP-Works packaged the FEM solvers of LS-DYNA and JOH/NIKE, which might be the first multistage system at that time and has been enjoying good reputation among users in Japan. To match the recent needs, ``faster, more accurate and easier'', of process designers and CAE engineers, a new metal forming simulation system JSTAMP-Works/NV is developed. The JSTAMP-Works/NV packaged the automatic healing function of CAD and had much more new capabilities such as prediction of 3D trimming lines for flanging or hemming, remote control of solver execution for multi-stage forming processes and shape evaluation between FEM and CAD. On the other way, a multi-stage multi-purpose inverse FEM solver HYSTAMP is developed and will be soon put into market, which is approved to be very fast, quite accurate and robust. Lastly, authors will give some application examples of user defined ductile damage subroutine in LS-DYNA for the estimation of material failure and springback in metal forming simulation.

Umezu, Yasuyoshi; Watanabe, Yuko; Ma, Ninshu

2005-08-01

192

Application of a multipurpose unequal probability stream survey in the Mid-Atlantic Coastal Plain  

USGS Publications Warehouse

A stratified, spatially balanced sample with unequal probability selection was used to design a multipurpose survey of headwater streams in the Mid-Atlantic Coastal Plain. Objectives for the survey include unbiased estimates of regional stream conditions, and adequate coverage of unusual but significant environmental settings to support empirical modeling of the factors affecting those conditions. The design and field application of the survey are discussed in light of these multiple objectives. A probability (random) sample of 175 first-order nontidal streams was selected for synoptic sampling of water chemistry and benthic and riparian ecology during late winter and spring 2000. Twenty-five streams were selected within each of seven hydrogeologic subregions (strata) that were delineated on the basis of physiography and surficial geology. In each subregion, unequal inclusion probabilities were used to provide an approximately even distribution of streams along a gradient of forested to developed (agricultural or urban) land in the contributing watershed. Alternate streams were also selected. Alternates were included in groups of five in each subregion when field reconnaissance demonstrated that primary streams were inaccessible or otherwise unusable. Despite the rejection and replacement of a considerable number of primary streams during reconnaissance (up to 40 percent in one subregion), the desired land use distribution was maintained within each hydrogeologic subregion without sacrificing the probabilistic design.

Ator, S. W.; Olsen, A. R.; Pitchford, A. M.; Denver, J. M.

2003-01-01

193

Feasibility study for a DOE research and production fuel multipurpose canister  

SciTech Connect

This is a report of the feasibility of multipurpose canisters for transporting, storing, and sing of Department of Energy research and production spent nuclear fuel. Six representative Department of Energy fuel assemblies were selected, and preconceptual canister designs were developed to accommodate these assemblies. The study considered physical interface, structural adequacy, criticality safety, shielding capability, thermal performance of the canisters, and fuel storage site infrastructure. The external envelope of the canisters was designed to fit within the overpack casks for commercial canisters being developed for the Department of Energy Office of Civilian Radioactive Waste Management. The budgetary cost of canisters to handle all fuel considered is estimated at $170.8M. One large conceptual boiling water reactor canister design, developed for the Office of Civilian Radioactive Waste Management, and two new canister designs can accommodate at least 85% of the volume of the Department of Energy fuel considered. Canister use minimizes public radiation exposure and is cost effective compared with bare fuel handling. Results suggest the need for additional study of issues affecting canister use and for conceptual design development of the three canisters.

Lopez, D.A.; Abbott, D.G.

1994-02-01

194

A case study: Transforming a vaudeville theatre into a 21st century multi-purpose hall  

NASA Astrophysics Data System (ADS)

Originally constructed in 1927 as an atmospheric, vaudeville theatre, the Coronado enjoyed 50 years as host to a true variety of events. In the 1970s, functional and space limitations became a catalyst for touring events to avoid the Coronado, and the theatre fell into disrepair. In the mid-1990s, a renovation was planned (completed January 2001) to restore the glory of the original theatre and upgrade it to be a viable multi-purpose hall for the 21st century. By annexing two neighboring buildings, many of the space limitations could be overcome in both the front- and back-of-house. The scope included a significantly enlarged stage and stagehouse, performer support spaces, expanded lobby spaces, quiet ventilation systems, and a new music rehearsal room. Acoustically, a primary goal was to upgrade the hall for both reinforced music/theatre performances and unreinforced, orchestral performances. However, historical regulations prevented modification to the room shape and configuration. In order to make the room suitable for unreinforced music, two primary acoustic features were instituted-a semi-custom concert enclosure for the stage and an acoustic enhancement system for the audience chamber. For theatrical and popular music events, a new performance audio system was designed and integrated into the hall.

Talaske, Richard H.; Hoffman, Ian B.; Laney, Jonathan P.

2002-05-01

195

Cultural Resource Investigations for a Multipurpose Haul Road on the Idaho National Laboratory  

SciTech Connect

The U. S. Department of Energy, Idaho Operations Office is considering options for construction of a multipurpose haul road to transport materials and wastes between the Materials and Fuels Complex (MFC) and other Idaho National Laboratory (INL) Site facilities. The proposed road will be closed to the public and designed for limited year-round use. Two primary options are under consideration: a new route south of the existing T-25 power line road and an upgrade to road T-24. In the Spring of 2010, archaeological field surveys and initial coordination and field reconnaissance with representatives from the Shoshone-Bannock Tribes were completed to identify any resources that may be adversely affected by the proposed road construction and to develop recommendations to protect any listed or eligible for listing on the National Register of Historic Places. The investigations showed that 24 archaeological resources and one historic marker are located in the area of potential effects for road construction and operation south of the T-25 powerline road and 27archaeological resources are located in the area of potential effects for road construction and operation along road T-24. Generalized tribal concerns regarding protection of natural resources were also documented in both road corridors. This report outlines recommendations for additional investigations and protective measures that can be implemented to minimize adverse impacts to the identified resources.

Brenda R. Pace; Cameron Brizzee; Hollie Gilbert; Clayton Marler; Julie Braun Williams

2010-08-01

196

Development of a high-current microwave ion source for Korean Multipurposed Accelerator (abstract)  

NASA Astrophysics Data System (ADS)

A high-current, proton linear accelerator, named as Korean multipurposed accelerator (KOMAC), is being proposed mainly for accelerator-driven transmutation technology (ADTT) by Korea Atomic Energy Research Institute (KAERI). High-current, low emittance continuous power (cw) linear accelerators favor electron cyclotron resonance (ECR) microwave ion sources as an injector (Ref. 1). Recently, these microwave sources are developed and constructed by several institutes especially for high-current cw linear accelerators. A high-density microwave ion source has been designed and constructed as a prototype ion source for the proposed KOMAC linear accelerator. The design of microwave power injection system is similar to that of the 75 keV proton injector at Los Alamos National Laboratory (Ref. 2). A 2.45 GHz, 1.5 kW magnetron source is introduced into the stainless steel plasma chamber with 10 cm diam and 20 cm length through a tapered, double-ridged waveguide and a quartz window. The microwave power supply is separated from the plasma chamber by a high-voltage waveguide break. Axial magnetic fields up to 1 kG can be provided by two sets of water-cooled solenoid coils. A single-hole extraction system is designed for extraction current up to 50 mA at 50 kV extraction voltage. The design and initial operations of the ion source in ECR regimes will be presented.

Hwang, Y. S.; Hong, I. S.; Kim, H. J.; Eom, G. S.; Cho, Y. S.; Choi, B. H.

1998-02-01

197

The multipurpose time-of-flight neutron reflectometer “Platypus” at Australia's OPAL reactor  

NASA Astrophysics Data System (ADS)

In this manuscript we describe the major components of the Platypus time-of-flight neutron reflectometer at the 20 MW OPAL reactor in Sydney, Australia. Platypus is a multipurpose spectrometer for the characterisation of solid thin films, materials adsorbed at the solid-liquid interface and free-liquid surfaces. It also has the capacity to study magnetic thin films using spin-polarised neutrons. Platypus utilises a white neutron beam (?=2-20 Å) that is pulsed using boron-coated disc chopper pairs; thus providing the capacity to tailor the wavelength resolution of the pulses to suit the system under investigation. Supermirror optical components are used to focus, deflect or spin-polarise the broad bandwidth neutron beams, and typical incident spectra are presented for each configuration. A series of neutron reflectivity datasets are presented, indicating the quality and flexibility of this spectrometer. Minimum reflectivity values of <10-7 are observed; while maximum thickness values of 325 nm have been measured for single-component films and 483 nm for a multilayer system. Off-specular measurements have also been made to investigate in-plane features as opposed to those normal to the sample surface. Finally, the first published studies conducted using the Platypus time-of-flight neutron reflectometer are presented.

James, M.; Nelson, A.; Holt, S. A.; Saerbeck, T.; Hamilton, W. A.; Klose, F.

2011-03-01

198

A multipurpose quality assurance phantom for the small animal radiation research platform (SARRP).  

PubMed

In this work, the suitability and performance of a mouse-size MOSFET (Mousefet) phantom is investigated for routine quality assurance (QA) of the small animal radiation research platform (SARRP). This Mousefet phantom is a simple construction consisting of five micro-MOSFETS custom integrated in a quincunx pattern within a tissue-equivalent phantom, allowing repeat/multiple QA tasks to be quickly performed in one experimental set-up. The Mousefet phantom is particularly evaluated for facilitating SARRP QA tasks which may warrant daily evaluation, including output constancy, isocenter congruency test and cone beam computed tomography (CBCT) image geometric accuracy. Results for the output constancy measurements showed a maximum daily variation of less than 2.6% for all MOSFETS, in consonance with observations from concurrent ion chamber measurements. It is also shown that the design of the Mousefet phantom allows the output check data to be used for prompt verification of beam energy and cone profile constancy. For the isocenter congruency test, it is demonstrated that the Mousefet phantom can detect 0.3 mm deviations of the CBCT isocenter from the radiation isocenter. Meanwhile, results for CBCT image geometric accuracy were consistently found to be within 2% of the expected value. Other CBCT image quality parameters could also be assessed in terms of image intensity constancy, noise and image uniformity. Overall, the results establish the Mousefet phantom as a simple and time-efficient multipurpose tool that could be employed effectively for routine QA of the SARRP. PMID:22491061

Ngwa, Wilfred; Tsiamas, Panagiotis; Zygmanski, Piotr; Makrigiorgos, G Mike; Berbeco, Ross I

2012-04-11

199

Probabilistic multichannel optical flow analysis based on a multipurpose visual representation of image sequences  

NASA Astrophysics Data System (ADS)

Directional filters are not normally used as pre-filters for optical flow estimation because orientation selectivity tends to increase the aperture problem. Despite this fact, here we apply a subband decomposition using directional spatio-temporal filters at different resolution to discriminate multiple motions at the same location. We first obtain multiple estimates of the velocity by applying the classic gradient constraint to the output of each filter. Spatio-temporal gradients of GD2 channel response are easily obtained as linear combinations of the set of 10 separable GD3 channel responses, which constitutes a multipurpose scheme for visual representation of image sequences. Then, we obtain an overdetermined linear system by imposing local constant velocity. This system is solved by least-squares yielding an estimate of the velocity and its covariance matrix. After segmenting the resulting 6 X 3 velocity estimates we combine them using Bayesian probability rules. Segmentation maintains the ability to represent multiple motions, while the combination of estimates reduces the aperture problem. Results for synthetic and real sequences are highly satisfactory. Mean errors in complex standard sequences are below those provided by most published methods.

Nestares, Oscar; Navarro, Rafael B.

1999-05-01

200

Synthesis of (2R, 3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, and evaluation of its proteasome inhibitory activities.  

PubMed

The total and semi syntheses of (2R, 3R)-epigallocatechin-3-O-(4-hydroxybenzoate), a novel catechin from Cistus salvifolius, was accomplished. The proteasome inhibition and cytotoxic activities of the synthetic compound and its acetyl derivative were studied and compared with (2R, 3R)-epigallocatechin-3-gallate (EGCG), the active component from green tea. PMID:21152270

Osanai, Kumi; Huo, Congde; Landis-Piwowar, Kristin R; Dou, Q Ping; Chan, Tak Hang

2007-08-01

201

Polycystin-1, 2, and STIM1 Interact with IP3R to Modulate ER Ca2+ Release through the PI3K/Akt Pathway  

PubMed Central

Dysregulation of Ca2+ signaling and homeostasis has been linked to the development of ADPKD through aberrant functioning of the polycystins. In this study, we investigated the role of the polycystins in modulating Ca2+ signaling. Expression of full-length PC1 in MDCK cells inhibited intracellular Ca2+ release in response to ATP when compared to control cells. This phenotype correlated with reduced interaction of endogenous PC2 and IP3R in PC1-containing cells. We also found that endogenous STIM1 also interacted with the IP3R, and this interaction was enhanced by PC1 expression. Increased interaction between STIM1 and IP3R inhibited Ca2+ release. PC1 regulates intracellular Ca2+ release and the interaction of PC2-IP3R-STIM1 through the PI3K/Akt signaling pathway. Inhibition of the PI3K/Akt pathway in PC1 containing cells restored intracellular Ca2+ release, increased the interaction between PC2 and IP3R and disrupted the STIM1-IP3R complex. Conversely, activation of the PI3K/Akt signaling pathway by HGF in control MDCK cells gave the reverse effects. It reduced the release of Ca2+ to levels comparable to the PC1 cells, inhibited the association PC2 and IP3R, and increased the interaction between STIM and IP3R. Overall, our studies provide a potential mechanism for the modulation of intracellular Ca2+ signaling by the polycystins.

Santoso, Netty G.; Cebotaru, Liudmila; Guggino, William B.

2011-01-01

202

Selective inhibition of gamma-aminobutyric acid aminotransferase by (3R,4R),(3S,4S)- and (3R,4S),(3S,4R)-4-amino-5-fluoro-3-phenylpentanoic acids.  

PubMed

(3R,4R),(3S,4S)- and (3R,4S),(3S,4R)-4-amino-5-fluoro-3-phenylpentanoic acid (1a and 1b) were synthesized and studied as selective inactivators of gamma-aminobutyric acid (GABA) aminotransferase. Neither compound caused time-dependent inactivation of the enzyme. Neither compound underwent enzyme-catalyzed transamination nor was fluoride ion eliminated from either compound by the enzyme. No 3-phenyllevulinic acid, the product of elimination of HF followed by enamine hydrolysis, was detected. However, both 1a and 1b were competitive reversible inhibitors of GABA aminotransferase; the Ki for 1a was smaller than the Km for GABA. These results suggest that 1a and 1b bind to the active site of GABA aminotransferase, but gamma-proton removal does not occur. Whereas (S)-4-amino-5-fluoropentanoic acid (AFPA) is a potent inhibitor of L-glutamic acid decarboxylase (GAD), neither 1a nor 1b at concentrations 40 times the Ki of AFPA caused any detectable competitive inhibition of GAD. Therefore, the incorporation of a phenyl substituent at the 3-position of AFPA confirms selective inhibition of GABA aminotransferase over GAD. PMID:2308143

Silverman, R B; Nanavati, S M

1990-03-01

203

Holographic Analysis of Kikuchi Electron Diffraction Data from Si(111)(? {3}x? {3})R30o-Al  

NASA Astrophysics Data System (ADS)

Holographic analysis was applied to Kikuchi electron diffraction data collected from the Si(111)(? {3}x? {3})R30o-Al structure to produce real-space images of the surface structure. Methods for calibrating the initial diffraction data are fully described. The images clearly show features caused by the Al atoms in the T4 absorption site. Measurements of the Al-Si bond length and the height of the Al above the top layer of Si agree with the values known from dynamical LEED studies.

Glander, G. S.

204

Phosphorylation of IP3R1 and the regulation of [Ca2+]i responses at fertilization: a role for the MAP kinase pathway  

PubMed Central

A sperm-induced intracellular Ca2+ signal ([Ca2+]i) underlies the initiation of embryo development in most species studied to date. The inositol 1,4,5 trisphosphate receptor type 1 (IP3R1) in mammals, or its homologue in other species, is thought to mediate the majority of this Ca2+ release. IP3R1-mediated Ca2+ release is regulated during oocyte maturation such that it reaches maximal effectiveness at the time of fertilization, which, in mammalian eggs, occurs at the metaphase stage of the second meiosis (MII). Consistent with this, the [Ca2+]i oscillations associated with fertilization in these species occur most prominently during the MII stage. In this study, we have examined the molecular underpinnings of IP3R1 function in eggs. Using mouse and Xenopus eggs, we show that IP3R1 is phosphorylated during both maturation and the first cell cycle at a MPM2-detectable epitope(s), which is known to be a target of kinases controlling the cell cycle. In vitro phosphorylation studies reveal that MAPK/ERK2, one of the M-phase kinases, phosphorylates IP3R1 at at least one highly conserved site, and that its mutation abrogates IP3R1 phosphorylation in this domain. Our studies also found that activation of the MAPK/ERK pathway is required for the IP3R1 MPM2 reactivity observed in mouse eggs, and that eggs deprived of the MAPK/ERK pathway during maturation fail to mount normal [Ca2+]i oscillations in response to agonists and show compromised IP3R1 function. These findings identify IP3R1 phosphorylation by M-phase kinases as a regulatory mechanism of IP3R1 function in eggs that serves to optimize [Ca2+]i release at fertilization.

Lee, Bora; Vermassen, Elke; Yoon, Sook-Young; Vanderheyden, Veerle; Ito, Junya; Alfandari, Dominique; De Smedt, Humbert; Parys, Jan B.; Fissore, Rafael A.

2010-01-01

205

Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour.  

PubMed

Drug-induced spoliation of hydrogels as contact lenses or as implants in the anterior eye is a frequent occurrence in clinical practice. This study explores the capacity of three commercial multipurpose solutions for contact lens care to reduce the spoliation of poly(2-hydroxyethyl methacrylate) (PHEMA) specimens exposed to a simulated aqueous humour formulation and to three topical drugs commonly administered after insertion of artificial corneas (Predsol, Optimol and Depo-Ralovera). ReNu MultiPlus (Bausch & Lomb), Complete Blink-N-Cleantrade mark Lens Drops (Allergan) and Complete Protein Remover Tablets dissolved in Complete ComfortPLUS (both from Allergan) were evaluated. All multipurpose solutions were able to dislodge passively the deposits formed on hydrogels in the simulated aqueous and in the presence of Predsol and Optimol, but none were effective against the deposits induced by Depo-Ralovera. A reduction of the calcium content in deposits caused by Predsol and Optimol was confirmed after treatment with the protein remover preparation, while the other multipurpose solutions caused the complete removal of the deposits. In experiments designed to evaluate the preventive action of the multipurpose solutions, no such effects were observed regardless of the drug involved. The prospect of using multipurpose solutions as eye drops following implantation of a hydrogel artificial cornea is a valid alternative for reducing device spoliation, however it appears to depend on the nature of the postoperative medication. PMID:16318831

Chirila, Traian V; Morrison, David A; Gridneva, Zoya; Meyrick, Danielle; Hicks, Celia R; Webb, John M

2004-10-31

206

The ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes.  

PubMed

Previous reports have shown a lower proportion of the ACTN3 X/X genotype (R577X nonsense polymorphism) in sprint-related athletes compared to the general population, possibly attributed to impairment of muscle function related to alpha-actinin-3 deficiency. In the present study, we examined the frequency of the X/X genotype in both Black and White elite-level bodybuilders and strength athletes in comparison to the general population. A reference population of 668 Whites (363 men and 305 women) and 208 Blacks (98 men and 110 women) was genotyped for the ACTN3 R577X polymorphism. Strength athletes (52 white and 23 black; 4 women) consisting predominantly of world class and locally competitive bodybuilders, and elite powerlifters were recruited and similarly genotyped. Significantly lower X/X genotype frequencies were observed in the athletes (6.7%) vs controls (16.3%; P=0.005). The X/X genotype was significantly lower in White athletes (9.7%) vs controls (19.9%; P=0.018). No black athletes (0%) were observed with the X/X genotype, though this finding only approached statistical significance vs controls (4.8%; P=0.10). The results indicate that the ACTN3 R577X nonsense allele (X) is under-represented in elite strength athletes, consistent with previous reports indicating that alpha-actinin-3 deficiency appears to impair muscle performance. PMID:18043716

Roth, Stephen M; Walsh, Sean; Liu, Dongmei; Metter, E Jeffrey; Ferrucci, Luigi; Hurley, Ben F

2007-11-28

207

The ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes  

PubMed Central

Previous reports have shown a lower proportion of the ACTN3 X/X genotype (R577X nonsense polymorphism) in sprint-related athletes compared to the general population, possibly attributed to impairment of muscle function related to ?-actinin-3 deficiency. In the present study, we examined the frequency of the X/X genotype in both Black and White elite-level bodybuilders and strength athletes in comparison to the general population. A reference population of 668 Whites (363 men and 305 women) and 208 Blacks (98 men and 110 women) was genotyped for the ACTN3 R577X polymorphism. Strength athletes (52 white and 23 black; 4 women) consisting predominantly of world class and locally competitive bodybuilders, and elite powerlifters were recruited and similarly genotyped. Significantly lower X/X genotype frequencies were observed in the athletes (6.7%) vs controls (16.3%; P = 0.005). The X/X genotype was significantly lower in White athletes (9.7%) vs controls (19.9%; P = 0.018). No black athletes (0%) were observed with the X/X genotype, though this finding only approached statistical significance vs controls (4.8%; P = 0.10). The results indicate that the ACTN3 R577X nonsense allele (X) is under-represented in elite strength athletes, consistent with previous reports indicating that ?-actinin-3 deficiency appears to impair muscle performance.

Roth, Stephen M; Walsh, Sean; Liu, Dongmei; Metter, E Jeffrey; Ferrucci, Luigi; Hurley, Ben F

2009-01-01

208

Molecular and crystalline structures of some (3R)-methyl-6(R)-isopropylcyclohexanone 2-arylidene derivatives modified by cyclopropanation  

NASA Astrophysics Data System (ADS)

Molecular structures of the series of 1(S)-(4X-phenyl)-5(R)-isopropyl-5Y-8(R)-methyl-3(R)-spiro[2,5]octan-4-ones (Y = H, X = F, Br, C6H5 and Y = CH3, X = Br, C6H5) as main products of the cyclopropanation reaction of the respective 3-methyl-6-isopropyl-6-Y-cyclohexanone 2-arylidene derivatives were studied by the NMR (1H and 13C) spectroscopy and X-ray diffraction analysis. All of compounds studied have the trans trans configuration (trans-orientation of the aryl and carbonyl groups with respect to each other and trans-position of the substituted cyclopropane CH2 link with respect to the methyl group at the chiral center of the cyclohexanone ring). Configurations 1(S)3(R)5(R)8(R) were determined for all of the products prepared. Conformation of the cyclohexanone ring with the axial methyl group and equatorial isopropyl one was found to dominate in reaction products similarly to the respective starting enones. Replacement of the CC double bond in the enone compounds with the cyclopropane ring has no effect on bond lengths between the fragments mentioned and the carbonyl or aryl groups.

Shishkina, S. V.; Zubatyuk, R. I.; Gella, I. M.; Drushlyak, T. G.; Pivnenko, N. S.; Kutulya, L. A.; Shishkin, O. V.

2007-04-01

209

The Evolution of Plasma Parameters on a Coronal Source Surface at 2.3 R ? during Solar Minimum  

NASA Astrophysics Data System (ADS)

We analyze data from the Solar and Heliospheric Observatory to produce global maps of coronal outflow velocities and densities in the regions where the solar wind is undergoing acceleration. The maps use UV and white light coronal data obtained from the Ultraviolet Coronagraph Spectrometer and the Large Angle Spectroscopic Coronagraph, respectively, and a Doppler dimming analysis to determine the mean outflow velocities. The outflow velocities are defined on a sphere at 2.3 R ? from Sun-center and are organized by Carrington Rotations during the solar minimum period at the start of solar cycle 23. We use the outflow velocity and density maps to show that while the solar minimum corona is relatively stable during its early stages, the shrinkage of the north polar hole in the later stages leads to changes in both the global areal expansion of the coronal hole and the derived internal flux tube expansion factors of the solar wind. The polar hole areal expansion factor and the flux tube expansion factors (between the coronal base and 2.3 R ?) start out as super-radial but then they become more nearly radial as the corona progresses away from solar minimum. The results also support the idea that the largest flux tube expansion factors are located near the coronal hole/streamer interface, at least during the deepest part of the solar minimum period.

Strachan, L.; Panasyuk, A. V.; Kohl, J. L.; Lamy, P.

2012-01-01

210

Meta-analysis of the ocular biocompatibility of a new multipurpose lens care system  

PubMed Central

Background The purpose of this paper is to evaluate the biocompatibility of a novel multipurpose solution (MPS) with a dual disinfectant system containing polyaminopropyl biguanide and polyquaternium-1 (Biotrue®) by analysis of biomicroscopy signs and adverse events in six large clinical trials. Methods Data from six consecutive, prospective clinical trials conducted from February 2008 to March 2010 were combined for meta-analysis. Subjects used the new MPS daily for periods of 2 weeks to 6 months. Slit-lamp signs were graded at each follow-up visit using an ordinal scale (0, one; 1, trace; 2, mild; 3, moderate; 4, severe). Analysis for biocompatibility included tracking of greater than grade 2 slit-lamp findings and number of adverse events. Results A total of 1,567 subjects (3,134 eyes) and 81 clinical investigators participated in the six studies, with 1,499 subjects completing the studies. Based on subject days in the studies, there were 72,904 exposures to the MPS and 7,212 biomicroscopy examinations. The completion rate for the studies was 96.3%. Per observation incidence of any finding greater than grade 2 at the follow-up visits were: corneal staining 0.08%, limbal injection 0.04%, bulbar injection 0.04%, tarsal conjunctiva abnormality 0.09%, and neovascularization 0.01%. There were no other slit-lamp signs greater than grade 2 and no statistically significant difference between hydrogels and silicone hydrogels for any finding. There were no reports of adverse events during the trials. Conclusion Analysis of over 72,000 daily exposures and 7,212 eye examinations showed that the novel MPS exhibited excellent biocompatibility in subjects using daily wear hydrogel or silicone hydrogel lenses.

Reindel, William; Merchea, Mohinder M; Rah, Marjorie J; Zhang, Lening

2013-01-01

211

GALEN: a third generation terminology tool to support a multipurpose national coding system for surgical procedures.  

PubMed

Generalised architecture for languages, encyclopedia and nomenclatures in medicine (GALEN) has developed a new generation of terminology tools based on a language independent model describing the semantics and allowing computer processing and multiple reuses as well as natural language understanding systems applications to facilitate the sharing and maintaining of consistent medical knowledge. During the European Union 4 Th. framework program project GALEN-IN-USE and later on within two contracts with the national health authorities we applied the modelling and the tools to the development of a new multipurpose coding system for surgical procedures named CCAM in a minority language country, France. On one hand, we contributed to a language independent knowledge repository and multilingual semantic dictionaries for multicultural Europe. On the other hand, we support the traditional process for creating a new coding system in medicine which is very much labour consuming by artificial intelligence tools using a medically oriented recursive ontology and natural language processing. We used an integrated software named CLAW (for classification workbench) to process French professional medical language rubrics produced by the national colleges of surgeons domain experts into intermediate dissections and to the Grail reference ontology model representation. From this language independent concept model representation, on one hand, we generate with the LNAT natural language generator controlled French natural language to support the finalization of the linguistic labels (first generation) in relation with the meanings of the conceptual system structure. On the other hand, the Claw classification manager proves to be very powerful to retrieve the initial domain experts rubrics list with different categories of concepts (second generation) within a semantic structured representation (third generation) bridge to the electronic patient record detailed terminology. PMID:10978911

Trombert-Paviot, B; Rodrigues, J M; Rogers, J E; Baud, R; van der Haring, E; Rassinoux, A M; Abrial, V; Clavel, L; Idir, H

2000-09-01

212

Totally implantable total artificial heart and ventricular assist device with multipurpose miniature electromechanical energy system.  

PubMed

A multipurpose miniature electromechanical energy system has been developed to yield a compact, efficient, durable, and biocompatible total artificial heart (TAH) and ventricular assist device (VAD). Associated controller-driver electronics were recently miniaturized and converted into hybrid circuits. The hybrid controller consists of a microprocessor and controller, motor driver, Hall sensor, and commutation circuit hybrids. The sizing study demonstrated that all these components can be incorporated in the pumping unit of the TAH and VAD, particularly in the centerpiece of the TAH and the motor housing of the VAD. Both TAH and VAD pumping units will start when their power line is connected to either the internal power pack or the external battery unit. As a redundant driving and diagnostic port, an emergency port was newly added and will be placed in subcutaneous location. In case of system failure, the skin will be cut down, and an external motor drive or a pneumatic driver will be connected to this port to run the TAH. This will minimize the circulatory arrest time. Overall efficiency of the TAH without the transcutaneous energy transmission system was 14-18% to deliver pump outputs of 4-9 L/min against the right and left afterload pressures of 25 and 100 mm Hg. The internal power requirement ranged from 6 to 13 W. The rechargeable batteries such as NiCd or NiMH with 1 AH capacity can run the TAH for 30-45 min. The external power requirement, when TETS efficiency of 75% was assumed, ranged from 8 to 18 W. The accelerated endurance test in the 42 degrees C saline bath demonstrated stable performance over 4 months. Long-term endurance and chronic animal studies will continue toward a system with 5 years durability by the year 2000. PMID:8141662

Takatani, S; Orime, Y; Tasai, K; Ohara, Y; Naito, K; Mizuguchi, K; Makinouchi, K; Damm, G; Glueck, J; Ling, J

1994-01-01

213

Intravaginal rings as delivery systems for microbicides and multipurpose prevention technologies  

PubMed Central

There is a renewed interest in delivering pharmaceutical products via intravaginal rings (IVRs). IVRs are flexible torus-shaped drug delivery systems that can be easily inserted and removed by the woman and that provide both sustained and controlled drug release, lasting for several weeks to several months. In terms of women’s health care products, it has been established that IVRs effectively deliver contraceptive steroids and steroids for the treatment of postmenopausal vaginal atrophy. A novel application for IVRs is the delivery of antiretroviral drugs for the prevention of human immunodeficiency virus (HIV) genital infection. Microbicides are antiviral drugs delivered topically for HIV prevention. Recent reviews of microbicide IVRs have focused on technologies in development and optimizing ring design. IVRs have several advantages, including the ability to deliver sustained drug doses for long periods of time while bypassing first pass metabolism in the gut. IVRs are discreet, woman-controlled, and do not require a trained provider for placement or fitting. Previous data support that women and their male sexual partners find IVRs highly acceptable. Multipurpose prevention technology (MPT) products provide protection against unintended/mistimed pregnancy and reproductive tract infections, including HIV. Several MPT IVRs are currently in development. Early clinical testing of new microbicide and MPT IVRs will require a focus on safety, pharmacokinetics and pharmacodynamics. Specifically, IVRs will have to deliver tissue concentrations of drugs that are pharmacodynamically active, do not cause mucosal alterations or inflammation, and do not change the resident microbiota. The emergence of resistance to antiretrovirals will need to be investigated. IVRs should not disrupt intercourse or have high rates of expulsion. Herein, we reviewed the microbicide and MPT IVRs currently in development, with a focus on the clinical aspects of IVR assessment and the challenges facing microbicide and MPT IVR product development, clinical testing, and implementation. The information in this review was drawn from PubMed searches and a recent microbicide/MPT product development workshop organized by CONRAD.

Thurman, Andrea Ries; Clark, Meredith R; Hurlburt, Jennifer A; Doncel, Gustavo F

2013-01-01

214

Multipurpose bedrock surficial, and environmental geologic maps, New River valley, southwest Virginia  

SciTech Connect

Multipurpose bedrock, surficial, and environmental geologic maps have recently been completed for portions of the Valley and Ridge province of southwest VA. The maps, at both 1:100,000 and 1:24,000 scales, show generalized and detailed bedrock geology grouped by lithology and environmental hazard associations. Also shown are a variety of alluvial, colluvial, debris flow, and landslide deposits, as well as karst features. Multidisciplinary research topics addressed during the mapping included slope evolution and geomorphology, drainage history and terrace distribution, ancient large-scale landsliding, and sinkhole development. The maps have been used by land-use planners and engineering firms in an evaluation of Appalachian paleoseismicity and to assess potential groundwater contamination and subsidence in karst areas. The maps are being used for environmental hazard assessment and site selection of a proposed large electric powerline that crosses the Jefferson National Forest. Also, the maps are proving useful in planning for a public access interpretive geologic enter focused on large-scale slope failures. Some of the largest known landslides in eastern North America took place within the map area. Field comparisons and detailed structure mapping of similar features along the Front Range of the Colorado Rockies indicate that the landslides were probably emplaced during a single catastrophic event of short duration. Although the giles County seismic zone is nearby, stability analyses of slopes in the map area have shown that failure need not have been initiated by a seismic event. Several distinct colluvial units mapped within the area of landslides document a period of extensive weathering that postdates slide emplacement. Radiocarbon dates from landslide sag ponds indicate a minimum age of 9,860 B.P. for emplacement of some of the landslides. These results indicate that pre-slide colluvial and debris flow deposits are at least Pleistocene in age.

Schultz, A. (Geological Survey, Reston, VA (United States)); Collins, T. (Forest Service, Roanoke, VA (United States))

1994-03-01

215

Determination of Amoebicidal Activities of Multipurpose Contact Lens Solutions by Using a Most Probable Number Enumeration Technique  

PubMed Central

Six multipurpose contact lens solutions [All-in-One, All-in-One (Light), ReNu MultiPlus, Optifree Express, Complete, and Solo-care soft] were tested for their efficacies against Acanthamoeba castellanii trophozoites and cysts by using a most probable number (MPN) technique for amoebic enumeration. Against trophozoites, All-in-One, ReNu Multiplus, and Optifree Express achieved total kill (log reduction of >3) after the manufacturer's minimum recommended disinfection time (MMRDT), with the remaining solutions failing to reach a log reduction of 1. After 24 h of exposure, all solutions proved trophozoiticidal, achieving, with the exception of Complete (log reduction of 3.13), total kill. Against cysts, All-in-One gave a log reduction of >3 within the MMRDT, with all other solutions failing to achieve a log reduction of 1. After 24 h of exposure, All-in-One achieved total kill of cysts (log reduction of 3.74), ReNu MultiPlus gave a log reduction of 3.15, and the remaining solutions reached log reductions of between 1.09 and 2.27. The MPN technique provides a simple, reliable, and reproducible method of amoebic enumeration that depends on simply establishing the presence or absence of growth on culture plates inoculated with a series of dilutions and determining the MPN of amoebae present from statistical tables. By use of this technique, two of the multipurpose solutions tested, ReNu MultiPlus and Optifree Express, demonstrated effective trophozoiticidal activities within the recommended disinfection times; however, only All-in-One proved effective against both trophozoites and cysts over the same time period. This MPN technique, which uses axenically produced trophozoites and mature, double-walled cysts, has the potential to form the basis of a national standard for amoebicidal efficacy testing of multipurpose contact lens disinfecting solutions.

Beattie, Tara K.; Seal, David V.; Tomlinson, Alan; McFadyen, Angus K.; Grimason, Anthony M.

2003-01-01

216

Design and fabrication of a multi-purpose soft x-ray array diagnostic system for KSTAR  

SciTech Connect

A multi-purpose soft x-ray array diagnostic system was developed for measuring two-dimensional x-ray emissivity profile, electron temperature, Ar impurity transport, and total radiation power. A remotely controlled filter wheel was designed with three different choices of filters. The electron temperature profile can be determined from the ratio of two channels having different thickness of Be layer, and the Ar impurity concentration transport can be determined from a pair of Ar Ross filters (CaF{sub 2} and NaCl thin films). Without any filters, this diagnostic system can also be used as a bolometer.

Lee, Seung Hun; Chai, Kil Byoung; Jang, Siwon; Choe, Wonho [Department of Physics, Korea Advanced Institute of Science and Technology 291 Daehak-ro, Yuseong-gu, Daejeon 305-701 (Korea, Republic of); Ko, Won-Ha; Kim, Junghee; Seo, Dongcheol; Lee, Jongha [National Fusion Research Institute, 169-148 Gwahak-ro, Yuseong-gu, Daejeon 305-806 (Korea, Republic of); Bogatu, I. N.; Kim, Jin-Soo [FAR-TECH, Inc., 10350 Science Center Drive, Building 14, Suite 150, San Diego, California 92121-1136 (United States)

2012-10-15

217

Design and fabrication of a multi-purpose soft x-ray array diagnostic system for KSTAR.  

PubMed

A multi-purpose soft x-ray array diagnostic system was developed for measuring two-dimensional x-ray emissivity profile, electron temperature, Ar impurity transport, and total radiation power. A remotely controlled filter wheel was designed with three different choices of filters. The electron temperature profile can be determined from the ratio of two channels having different thickness of Be layer, and the Ar impurity concentration transport can be determined from a pair of Ar Ross filters (CaF(2) and NaCl thin films). Without any filters, this diagnostic system can also be used as a bolometer. PMID:23127019

Lee, Seung Hun; Chai, Kil Byoung; Jang, Siwon; Ko, Won-Ha; Kim, Junghee; Seo, Dongcheol; Lee, Jongha; Bogatu, I N; Kim, Jin-Soo; Choe, Wonho

2012-10-01

218

Design and fabrication of a multi-purpose soft x-ray array diagnostic system for KSTAR  

NASA Astrophysics Data System (ADS)

A multi-purpose soft x-ray array diagnostic system was developed for measuring two-dimensional x-ray emissivity profile, electron temperature, Ar impurity transport, and total radiation power. A remotely controlled filter wheel was designed with three different choices of filters. The electron temperature profile can be determined from the ratio of two channels having different thickness of Be layer, and the Ar impurity concentration transport can be determined from a pair of Ar Ross filters (CaF2 and NaCl thin films). Without any filters, this diagnostic system can also be used as a bolometer.

Lee, Seung Hun; Chai, Kil Byoung; Jang, Siwon; Ko, Won-Ha; Kim, Junghee; Seo, Dongcheol; Lee, Jongha; Bogatu, I. N.; Kim, Jin-Soo; Choe, Wonho

2012-10-01

219

An Arabic dictionary of technical alchemical terms: MS Sprenger 1908 of the Staatsbibliothek zu Berlin (fols. 3r-6r).  

PubMed

The Arabic MS Sprenger 1908 (Staatsbibliothek, Berlin) is a handbook of medieval alchemy. Among the works it preserves, we can find the only extant witness to the Arabic original of the well-known Liber de aluminibus et salibus. In this paper, I focus on a detailed alchemical dictionary preserved in this manuscript (fols. 3r-6r) whose explicit aim is to clarify the meaning of the secret language used by the alchemists to conceal the names of substances and operations. Other versions of the same alchemical lexicon are found in Syriac and karsuni in MSS Oriental 1593 and Egerton 709, both preserved in the British Library. After describing these manuscripts, I analyse the contents of this dictionary, its structure, its different versions, and the features of the alchemical language that it attests to, providing some examples to show how this kind of dictionary is still a useful tool for the contemporary researcher. PMID:19831258

Ferrario, Gabriele

2009-03-01

220

Exceptionally strong magnetism in the 4d perovskites RTcO3 (R=Ca, Sr, Ba)  

NASA Astrophysics Data System (ADS)

The evolution of the magnetic ordering temperature of the 4d3 perovskites RTcO3 (R=Ca, Sr, Ba) and its relation with its electronic and structural properties has been studied by means of hybrid density functional theory and Monte Carlo simulations. When compared to the most widely studied 3d perovskites the large spatial extent of the 4d shells and their relatively strong hybridization with oxygen weaken the tendency to form Jahn-Teller like orbital ordering. This strengthens the superexchange interaction. The resulting insulating G-type antiferromagnetic ground state is characterized by large superexchange coupling constants (26-35 meV) and Neél temperatures (750-1200 K). These monotonically increase as a function of the R ionic radius due to the progressive enhancement of the volume and the associated decrease of the cooperative rotation of the TcO6 octahedra.

Franchini, C.; Archer, T.; He, Jiangang; Chen, Xing-Qiu; Filippetti, A.; Sanvito, S.

2011-06-01

221

Pressure-induced structural and vibrational evolution in ferroelectric RInO3 (R=Eu, Gd, Dy)  

NASA Astrophysics Data System (ADS)

The structural and vibrational properties of the hexagonal indates RInO3 (R=Eu, Gd and Dy) have been studied under high pressures using synchrotron x-ray diffraction and Raman scattering in diamond anvil cells. The three hexagonal structures exhibit anisotropic compression behaviors under high pressures and are stable up to ~17 GPa. High-pressure Raman spectra show that most frequencies harden linearly with different rates under high pressures. At ~17 GPa, three compounds undergo similar phase transitions. It is hard to indentify the structure of the high-pressure phase due to the broad x-ray diffraction and Raman patterns which could result from the kinetic hindrance of the phase transition at room temperature.

Lin, Chuanlong; Liu, Jing; Li, Yanchun; Li, Xiaodong; Li, Rui

2013-11-01

222

Synthesis and structural and electrical characterization of new materials Bi3R2FeTi3O15  

NASA Astrophysics Data System (ADS)

In this work we report the synthesis of polycrystalline samples of Bi5FeTi3O15 and Bi3R2FeTi3O15 new compounds with R=Nd, Sm, Gd, Dy, Ho and Yb. The materials were synthesized by the standard solid state reaction recipe from high purity (99.99%) powders. The structural characteristics of materials were analyzed by X-ray diffraction experiments. Rietveld refinement by the GSAS code was performed, taking the input data from the ICSD 74037 database. Results reveal that materials crystallized in orthorhombic single-phase structures and space group Fmm2. Measurements of polarization as a function of applied electric field were carried out using a Radiant Technology polarimeter. We determine the occurrence of hysteretic behaviors, which are characteristic of ferroelectric materials. The main values of remnant and coercive applied fields were observed for substitutions with Yb and Nd, which have the main atomic radii.

Gil Novoa, O. D.; Landínez Téllez, D. A.; Roa-Rojas, J.

2012-08-01

223

The atomic geometries of the ordered (2 × 2) and (?3 × ?3)R30° phases of K, Rb, and Cs on Rh(111) in comparison with Ru(0001)  

Microsoft Academic Search

The local adsorption geometries of K, Rb and Cs in the (?3 × ?3)R30° and (2 × 2) phases on a Rh(111) surface at coverages of 0.33 and 0.25 ML, respectively, are determined by analyzing LEED intensity data. For all (?3 × ?3)R30° phases investigated, the three-fold hcp site is found. For the (2 × 2) overlayer, K remains in

S. Schwegmann; H. Over

1996-01-01

224

Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library  

PubMed Central

Background While there is strong evidence for phosphatidylinositol 3-kinase (PI3K) involvement in cancer development, there is limited information about the role of PI3K regulatory subunits. PIK3R3, the gene that encodes the PI3K regulatory subunit p55?, is over-expressed in glioblastoma and ovarian cancers, but its expression in gastric cancer (GC) is not known. We thus used genetic and bioinformatic approaches to examine PIK3R3 expression and function in GC, the second leading cause of cancer mortality world-wide and highly prevalent among Asians. Methods Primary GC and matched non-neoplastic mucosa tissue specimens from a unique Asian patient gastric cancer library were comprehensively profiled with platforms that measured genome-wide mRNA expression, DNA copy number variation, and DNA methylation status. Function of PIK3R3 was predicted by IPA pathway analysis of co-regulated genes with PIK3R3, and further investigated by siRNA knockdown studies. Cell proliferation was estimated by crystal violet dye elution and BrdU incorporation assay. Cell cycle distribution was analysed by FACS. Results PIK3R3 was significantly up-regulated in GC specimens (n?=?126, p?3R3 promoted cellular growth and proliferation. Knockdown of PIK3R3 decreased the growth of GC cells, induced G0/G1 cell cycle arrest, decreased retinoblastoma protein (Rb) phosphorylation, cyclin D1, and PCNA expression. Conclusion Using a combination of genetic, bioinformatic, and molecular biological approaches, we showed that PIK3R3 was up-regulated in GC and promoted cell cycle progression and proliferation; and thus may be a potential new therapeutic target for GC.

2012-01-01

225

A study of the relative effectiveness of a textbook-study system (SQ3R), its variation (SRQ2R), and structure of text instruction  

Microsoft Academic Search

Many reading authorities have recommended that educators teach Robinson's (1946) textbook-study system, SQ3R, to elementary through college students as a way of enhancing their ability to comprehend and retain expository information. The research by Rothkopf (1966) and others into adjunct questioning has led some authorities to advocate moving the questioning stage in the SQ3R system to follow rather than precede

Michael Leon Walker

1991-01-01

226

Fifth International Poplar Symposium: 'Poplars and willows: from research models to multipurpose trees for a bio-based society'.  

PubMed

Carefully managed tree plantations offer an opportunity for sustainable biomass production. In recent years, the responses of the Salicaceae to environmental constraints have increasingly been investigated at different levels of biological integration, giving rise to a physiological approach to the function of trees in environmental restoration and monitoring. Significant progress has been achieved by the poplar and willow community in understanding targeted characteristics of complex tree stress responses. The Fifth International Poplar Symposium brought together experts in this area, with the main objective being to improve, coordinate and communicate existing national research on the biological and environmental dimension of multifunctional poplar and willow plantations. The secondary objective was to develop a network of research scientists and extension workers to provide scientific support for subjects interested in using fast-growing poplar and willow species for tree-related environmental projects. The ultimate goal was to build up services for the multipurpose tree plantation network on local-level management in order to obtain maximized benefits from tree crops. The purpose was also to maximize the synergy between local knowledge and global-level processes that require information on multipurpose tree crop production. PMID:22158009

Tognetti, Roberto; Massacci, Angelo; Mugnozza, Giuseppe Scarascia

2011-12-01

227

Vegetative and reproductive phenology of some multipurpose tree species in the homegardens of Barak Valley, northeast India.  

PubMed

Traditional homegardens are an important component of the farming systems in many rural communities and have been highlighted considerably due to their sustainability and role in the conservation of biodiversity. However, the functional aspect of the homegardens, which includes the phenological behavior of the dominant tree species in such agroforestry systems, has been undermined till date, and there is a lack of adequate data on this aspect of the traditional homegardens. As a step in this direction the present study was carried out to determine the phenological behavior of important multipurpose trees in the homegardens of the village of Dargakona, Assam, northeast India. The study revealed the dominance of periodic growth deciduous species from a total of 25 tree species selected for phenological observation. The diversity of multipurpose trees in the homegardens is represented by different plant functional types with different phenological behavior which showed significant changes in their responses to inter-annual climatic variations. The diversity of tree species with different phenological behavior has implications for the temporal partitioning of resources, especially during periods of scarcity, thereby resulting in efficient utilization of resources such as water. Also the diverse phenological behavior plays an important role in regulating the food supply for the herbivore population and the year-round availability of products, and such information can be useful in the selection of species for integration into other agroforestry systems which can be sustainable in the long run. PMID:22555388

Das, Tapasi; Das, Ashesh Kumar

2012-05-04

228

Effect of contact lens material on cytotoxicity potential of multipurpose solutions using human corneal epithelial cells  

PubMed Central

Purpose Multipurpose solutions (MPS) are used daily to clean and disinfect silicone hydrogel (SiHy) contact lenses. This in vitro study was undertaken to identify the potential for interaction between MPS, SiHy surface treatments, and lens materials, which may lead to changes in the response of human corneal epithelial cells (HCEC) to MPS-soaked lenses. Methods The MPS tested were renu fresh (formerly known as ReNu MultiPlus; ReNu), OptiFree Express (OFX), OptiFree RepleniSH, SoloCare Aqua, and Complete Moisture Plus. The SiHy materials evaluated were lotrafilcon A, lotrafilcon B, comfilcon A, galyfilcon A, and balafilcon A (BA). MPS-soaked lenses were placed on top of adherent HCEC. The effect of MPS dilutions (0.1 to 10% final concentration in medium) was also characterized. Cell viability, adhesion phenotype and caspase activation were studied after 24-h cell exposure. OFX released from lenses was determined using UV absorbance. Results A significant reduction in viability (between 30 to 50%) was observed with cells exposed to lenses soaked in ReNu and OFX. A significant downregulation of ?3 and ?1 integrins, with integrin expression ranging from 60% to 75% of control (cells with no lens), was also observed with OFX and ReNu-soaked lenses. With the exception of BA, all other lenses soaked in OFX resulted in significant caspase activation, whereby over 18% of cells stained positive for caspases. Minimal caspase activation was observed in cells exposed to ReNu and Solo soaked lenses. For both OFX and ReNu, exposing cells to at least a 5% dilution had a significant effect on viability and integrin expression. While Complete and Solo did not lead to reduction in viability, cells exposed to a 10% dilution showed reduced integrin expression down to less than 70% of control value. Comparing cell response to diluted MPS solutions and various MPS-soaked lenses showed that it is not possible to reliably use cell response to MPS dilution alone to assess MPS biocompatibility. Conclusions Our results demonstrate that the reaction of HCEC to MPS are affected by the type of lenses the MPS is released from and may potentially be influenced by the surface treatment (or lack of it) of SiHy materials.

Tanti, N.C.; Crockett, B.; Mansour, L.; Jones, L.

2011-01-01

229

Understanding multi-purpose hybrid voluntary organizations: The contributions of theories on civil society, social movements and non-profit organizations  

Microsoft Academic Search

The paper offers a theoretical framework to study the conditions that lead to the emergence of multi-purpose hybrid voluntary organizations and the factors that influence their ability to mobilize resources and enlist commitment. These organizations are characterized by four interrelated attributes: (a) they set out as their mission to uphold and promote cultural values that are typically at variant with

Yeheskel Hasenfeld; Benjamin Gidron

2005-01-01

230

Effect of supplementation of maize stover with foliage of various tropical multipurpose trees and Lablab purpureus on intake, rumen fermentation, digesta kinetics and microbial protein supply of sheep  

Microsoft Academic Search

Foliage of four multipurpose trees (Calliandra calothyrsus, Chamaecytisus palmensis, Leucaena diversifolia and Vernonia amygdalina) and a woody leguminous perennial (Lablab purpureus) were evaluated for their potential as protein supplements for sheep fed maize stover ad libitum. The chemical composition of the feed was analysed, and maize stover degradation, rumen kinetics, passage rate were measured and enumeration of microbial population in

I. K Hindrichsen; P. O Osuji; A. A Odenyo; J Madsen; T Hvelplund

2004-01-01

231

The Role of Multipurpose C.A.Es: The Institutional and Staff Perspectives 1974-1975. C.A.T. Education Monograph No. 24.  

ERIC Educational Resources Information Center

The attitudes and ideologies of staff and institutional administrators concerning the role of the multipurpose colleges of advanced education in tertiary education in Australia were investigated. The data for the investigation were gathered using two different questionnaires sent to academic staff in civil and mechanical engineering, architecture…

Davis, D. J.; Hermann, G. D.

232

Nutritional and anti-nutritional characters and rumen degradability of dry matter and nitrogen for some multipurpose tree species with potential for agroforestry in Zimbabwe  

Microsoft Academic Search

In a preliminary study on the nutritional value of seven multipurpose trees (MPTs), currently showing potential use in agroforestry systems in Zimbabwe, crude protein values ranged from 189 g kg?1 DM in Flemingia macrophylla to 292 g kg?1 DM in Acacia angustissima. Acid detergent fibre (ADF) content was low especially in Sesbania sesban (99 g kg?1 DM), while ADF contents

B. H. Dzowela; L. Hove; J. H. Topps; P. L. Mafongoya

1995-01-01

233

Impact of assay selection and study design on the outcome of cytotoxicity testing of medical devices: The case of multi-purpose vision care solutions  

Microsoft Academic Search

Medical device biocompatibility testing usually includes a cytotoxicity component. Assay selection and protocol design often depend on a specific testing standard rather than on the characteristics of the medical device. To better understand the impact of assay selection on study outcome of unstructured medical devices, we evaluated contact lens multi-purpose solutions (MPS) in the agar diffusion, direct contact and two

David M. Lehmann; Mary E. Richardson

2010-01-01

234

In vitro and in situ evaluation of selected multipurpose trees, wheat bran and Lablab purpureus as potential feed supplements to tef ( Eragrostis tef) straw  

Microsoft Academic Search

In vitro and in situ evaluations of feed samples were carried out at Debre Zeit Research Station (Ethiopia) of the International Livestock Research Institute. The feed samples consisted of tef straw, wheat bran, dried Lablab purpureus, and dried foliage of the multipurpose trees (MPT), namely Sesbania sesban 1198, Sesbania sesban 15019, Acacia angustissima 15132, Leucaena pallida 14203, and mixtures of

Solomon Melaku; Kurt J Peters; Azage Tegegne

2003-01-01

235

Nucleation and growth of Ag islands on the (.sqroot.3 × .sqroot.3)R30° phase of Ag on Si(111)  

SciTech Connect

We use scanning tunneling microscopy to measure densities and characteristics of Ag islands that form on the ({radical}3 x {radical}3)R30{sup o}-Ag phase on Si(111), as a function of deposition temperature. Nucleation theory predicts that the logarithm of island density varies linearly with inverse deposition temperature. The data show two linear regimes. At 50-125 K, islands are relatively small, and island density decreases only slightly with increasing temperature. At 180-250 K, islands are larger and polycrystalline, and island density decreases strongly with increasing temperature. At 300 K, Ag atoms can travel for distances of the order of 1 {micro}m. Assuming that Ag diffusion occurs via thermally activated motion of single atoms between adjacent sites, the data can be explained as follows. At 50-125 K, the island density does not follow conventional Arrhenius scaling due to limited mobility and a consequent breakdown of the steady-state condition for the adatom density. At {approx} 115-125 K, a transition to conventional Arrhenius scaling with critical nucleus size (i = 1) begins, and at 180-250 K, i > 1 prevails. The transition points indicate a diffusion barrier of 0.20-0.23 eV and a pairwise Ag-Ag bond strength of 0.14 eV. These energy values lead to an estimate of i {approx} 3-4 in the regime 180-250 K, where island density varies strongly with temperature.

Belianinov, A.; Unal, B.; Ho, K.-M.; Wang, C.-Z.; Evans, J. W.; Tringides, M. C.; Thiel, P. A.

2011-06-06

236

Obstacle course: users' maneuverability and movement efficiency when using Otto Bock C-Leg, Otto Bock 3R60, and CaTech SNS prosthetic knee joints.  

PubMed

The performance and movement efficiency of prosthesis users while traversing a multisectional obstacle course (OC) were evaluated using a crossover design with random allocation of three prosthetic knee joints: the SNS (CaTech; Dayton, Ohio) the C-Leg (Otto Bock; Duderstadt, Germany), and the 3R60 (Otto Bock). Twelve users completed the OC twice with each joint, once without and once with a mental loading task (MLT). The performance was objectively assessed using time measurement from digital video recordings, and the Total Heart Beat Index was used to estimate movement efficiency. A 1 mo familiarization period was provided for each knee joint before data collection. It took longer to complete the OC with the 3R60 compared with either the SNS or the C-Leg. No significant time differences were found between the C-Leg and the SNS, but differences between the 3R60 and the SNS (slalom and rock sections) and between the 3R60 and the C-Leg (rock section) were observed. Within the simulated sand section, two participants fell with the C-Leg, one with the 3R60, and none with the SNS. Movement efficiency without MLT was similar between all joints, but with an MLT a significant decrease in movement efficiency was observed with the C-Leg. Previous experience using an SNS had no influence on the results. PMID:22773261

Meier, Margrit R; Hansen, Andrew H; Gard, Steven A; McFadyen, Angus K

2012-01-01

237

IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice  

PubMed Central

The type 1 inositol 1,4,5- trisphosphate receptor (IP3R1) is a Ca2+ channel on the endoplasmic reticulum and is a predominant isoform in the brain among the three types of IP3Rs. Mice lacking IP3R1 show seizure-like behavior; however the cellular and neural circuit mechanism by which IP3R1 deletion causes the abnormal movements is unknown. Here, we found that the conditional knockout mice lacking IP3R1 specifically in the cerebellum and brainstem experience dystonia and show that cerebellar Purkinje cell (PC) firing patterns were coupled to specific dystonic movements. Recordings in freely behaving mice revealed epochs of low and high frequency PC complex spikes linked to body extension and rigidity, respectively. Remarkably, dystonic symptoms were independent of the basal ganglia, and could be rescued by inactivation of the cerebellum, inferior olive or in the absence of PCs. These findings implicate IP3R1-dependent PC firing patterns in cerebellum in motor coordination and the expression of dystonia through the olivo-cerebellar pathway.

Hisatsune, Chihiro; Miyamoto, Hiroyuki; Hirono, Moritoshi; Yamaguchi, Naohide; Sugawara, Takeyuki; Ogawa, Naoko; Ebisui, Etsuko; Ohshima, Toshio; Yamada, Masahisa; Hensch, Takao K.; Hattori, Mitsuharu; Mikoshiba, Katsuhiko

2013-01-01

238

Environmental assessment for the reuse of TNX as a multi-purpose pilot plant campus at the Savannah River Site  

SciTech Connect

The Department of Energy (DOE) prepared this environmental assessment (EA) to analyze the potential environmental and safety impacts of DOE planning to allow asset reuse of the TNX Area at the Savannah River Site (SRS) located near Aiken, South Carolina. The proposed action would include providing for a location for the Centers of Excellence at or adjacent to SRS and entering into a cooperative agreement with a non-profit management and operations (management firm) contractor to operate and market the TNX facilities and equipment. The area (formerly TNX) would be called a Multi-Purpose Pilot Plant Campus (MPPC) and would be used: (1) as location for technology research, development, demonstration, and commercial operations; (2) to establish partnerships with industry to develop applied technologies for commercialization; and (3) serve as administrative headquarters for Centers of Excellence in the program areas of soil remediation, radioecology, groundwater contamination, and municipal solid waste minimization.

NONE

1998-07-01

239

MGEANT-A GEANT-based multi-purpose simulation package for gamma-ray astronomy missions  

NASA Astrophysics Data System (ADS)

MGEANT is a multi-purpose simulation package based on the CERN GEANT package and Program Library. This package allows for the rapid prototyping of a wide variety of gamma-ray detector systems. The two main advantages of this package over standard GEANT simulations are 1) the detector geometry and material data are supplied via input files instead of being hard coded and 2) MGEANT has several built in spectral and beam options including the ability to simulate observations with multiple pointings and diffuse sources. We are currently using MGEANT to produce detailed observation simulations and response matrices for INTEGRAL/SPI. We present a sample of the type of work that has been done at GSFC using MGEANT simulations. This software package is available from our website http://lheawww.gsfc.nasa.gov/docs/gamcosray/legr/integral/. .

Sturner, S. J.; Seifert, H.; Shrader, C.; Teegarden, B. J.

2000-04-01

240

K/FAST - The U.S. Army's NDI multi-purpose Ku-band fly-away Satcom terminal  

NASA Astrophysics Data System (ADS)

Attention is given to K/FAST, a NDI multi-purpose Ku-band fly-away Satcom terminal, and the ways in which it epitomizes current trends in military C3I. K/FAST is a state-of-the-art, all solid-state Ku-band terminal providing medium data rate (less than T1) capability. It is designed to accept a GFE bulk encryptor, and includes a multiplexer subsystem with plug-in jacks for secure or nonsecure phones. The multiplexer is reconfigurable, in the field, and permits a mix of compressed voice, data, facsimile, and compressed video. It is demonstrated that off-the-shelf state-of-the-art NDI hardware can be integrated to meet military mission requirements while bypassing the typical multiyear DOD research-and-development cycle.

Kelly, Alexander J.; Bernard, Robert A.; Stevens, Peter E.; D'Alessandro, Maryann

1992-03-01

241

Development of a multipurpose vacuum chamber for serial optical and diffraction experiments with free electron laser radiation  

SciTech Connect

In this paper we present a development of a multipurpose vacuum chamber which primal function is to be used in pump/probe experiments with free electron laser (FEL) radiation. The chamber is constructed for serial diffraction and serial spectroscopy allowing a fast exchange of samples during the measurement process. For the fast exchange of samples, liquid jet systems are used. Both applications, utilizing soft x-ray FEL pulses as pump and optical laser pulses as probe and vice versa are documented. Experiments with solid samples as well as the liquid jet samples are presented. When working with liquid jets, a system of automatically refilled liquid traps for capturing liquids has been developed in order to ensure stable vacuum conditions. Differential pumping stages are placed in between the FEL beamline and the experimental chamber so that working pressure in the chamber can be up to four orders of magnitude higher than the pressure in the FEL beamline.

Rajkovic, I.; Hallmann, J.; Gruebel, S.; More, R.; Quevedo, W.; Petri, M.; Techert, S. [Department of Structural Dynamics of (Bio)chemical Systems, Max Planck Institute for Biophysical Chemistry, 37070 Goettingen (Germany)

2010-04-15

242

X-ray photoelectron diffraction from (3×3) and (&sqrt;3×&sqrt;3)R 30° (0001)Si 6H–SiC surfaces  

Microsoft Academic Search

High-resolution (±1°) x-ray photoelectron diffraction (XPD) patterns were obtained along high symmetry azimuths of the (3×3) and (&sqrt;3×&sqrt;3)R30° reconstructed (0001)Si 6H–SiC surfaces. The data were compared to XPD patterns obtained from (7×7) Si (111) as well as to models proposed for the (3×3) and (&sqrt;3×&sqrt;3)R30° 6H–SiC reconstructions. Forward scattering features similar to those observed from the (7×7) Si (111) were

S. W. King; C. Ronning; R. F. Davis; R. S. Busby; R. J. Nemanich

1998-01-01

243

X-ray photoelectron diffraction from (3×3) and (&surd;3×&surd;3)R 30° (0001)Si 6H-SiC surfaces  

Microsoft Academic Search

High-resolution (+\\/-1°) x-ray photoelectron diffraction (XPD) patterns were obtained along high symmetry azimuths of the (3×3) and (&surd;3×&surd;3)R30° reconstructed (0001)Si 6H-SiC surfaces. The data were compared to XPD patterns obtained from (7×7) Si (111) as well as to models proposed for the (3×3) and (&surd;3×&surd;3)R30° 6H-SiC reconstructions. Forward scattering features similar to those observed from the (7×7) Si (111) were

S. W. King; C. Ronning; R. F. Davis; R. S. Busby; R. J. Nemanich

1998-01-01

244

Microtropins A-I: 6'-O-(2?S,3?R)-2?-ethyl-2?,3?-dihydroxybutyrates of aliphatic alcohol ?-D-glucopyranosides from the branches of Microtropis japonica.  

PubMed

From the branches of Microtropis japonica (Celastraceae), nine aliphatic glucosides, named microtropins A-I, were isolated. The 6-position of glucose was esterified with (2S,3R)-2-ethyl-2,3-dihydroxybutyric acid. Microtropins A-D contained a rare natured product nitrile functional group in their aglycones. The absolute structures of the (2S,3R)-2-ethyl-2,3-dihydroxybutyric acid moiety and aglycone of microtropin A were determined by an X-ray crystallographic method. PMID:23218610

Uemura, Yuka; Sugimoto, Sachiko; Matsunami, Katsuyoshi; Otsuka, Hideaki; Takeda, Yoshio; Kawahata, Masatoshi; Yamaguchi, Kentaro

2012-12-05

245

ESCRT Machinery Potentiates HIV-1 Utilization of the PI(4,5)P2-PLC-IP3R-Ca2+ Signaling Cascade  

PubMed Central

HIV-1 release efficiency is directed by late (L) domain motifs in the viral structural precursor polyprotein, Gag, which serve as links to the ESCRT (endocytic sorting complex required for transport) machinery. Linkage is normally through binding of Tsg101, an ESCRT-1 component, to the P7TAP motif in the p6 region of Gag. In its absence, budding is directed by binding of Alix, an ESCRT adaptor protein, to the LY36PXnL motif in Gag. We recently showed that budding requires activation of the inositol 1,4,5-triphosphate receptor (IP3R), a protein that “gates” Ca2+ release from intracellular stores, triggers Ca2+ cell influx and thereby functions as a major regulator of Ca2+ signaling. In the present study, we determined whether the L domain links Gag to Ca2+ signaling machinery. Depletion of IP3R and inactivation of phospholipase C (PLC) inhibited budding whether or not Tsg101 was bound to Gag. PLC hydrolysis of PI(4,5)P2 generates IP3, the ligand that activates IP3R. However, with Tsg101 bound, Gag release was independent of Gq-mediated activation of PLC and budding was readily enhanced by pharmacological stimulation of PLC. Moreover, IP3R was redistributed to the cell periphery and cytosolic Ca2+ was elevated, events indicative of induction of Ca2+ signaling. The results suggest that L domain function, ESCRT machinery, and Ca2+signaling are linked events in Gag release.

Ehrlich, Lorna S.; Medina, Gisselle N.; Carter, Carol A.

2011-01-01

246

Evolutionary sequenomics: The utility of comparative chromosomal synteny searches in revealing homologous DNA blocks derived from fish-specific 3R- and 4R-genome duplications  

Technology Transfer Automated Retrieval System (TEKTRAN)

Most Actinopterygian fishes are believed to have arisen from a whole genome duplication approximately 275-350 MYA (3R duplication). Within the teleosts, several orders possess additional species that have undergone either an additional whole genome autopolyploid duplication (4R duplication), or are...

247

A Quasi-Experimental Study of Adolescent Learning Using the SQ3R Strategy Instruction with Web-Based Learning Materials  

ERIC Educational Resources Information Center

|The purpose of this quantitative study was to explore the effects of strategy instruction on lower and higher-level learning in the hypertext format of a WebQuest. The SQ3R and Classification/Categorization study strategies were used to investigate the effects of comprehension in a recall and essay task. Two hundred fifty-four eighth-grade…

Guzniczak, Lizabeth A.

2007-01-01

248

A Monte Carlo simulation for the stripping of the &sqrt;3×&sqrt;3 R30° alkanethiol lattice from Au(111) terraces and steps  

Microsoft Academic Search

Monte Carlo simulations of a model for the stripping of &sqrt;3×&sqrt;3 R30° alkanethiol lattices from terraces and steps of a (111) metal face in aqueous solutions are presented. In the model the stripping probability of an adsorbed alkanethiolate molecule depends on the applied potential, on intermolecular forces that stabilize the alkanethiol layer, and on the presence of substrate defects. Stabilizing

H. Martin; C. Vericat; G. Andreasen; M. E. Vela; R. C. Salvarezza

2002-01-01

249

[Enhanced electro-chemical oxidation of Acid Red 3R solution with phosphotungstic acid supported on gamma-Al2O3].  

PubMed

Supported phosphotungstic acid catalysts on gamma-Al2O3 (HPW/gamma-Al2O3) were prepared by solution impregnation and characterized by FTIR, XRD, TG-DTA and SEM. The heteropolyanion shows a Keggin structure. Electro-chemical oxidation of Acid Red 3R was investigated in the presence of HPW supported on gamma-Al2O3 as packing materials in the reactor. The results show that HPW/gamma-Al2O3 has a good catalytic activity for decolorization of Acid Red 3R. When HPW loading was 4.6%, pH value of Acid Red 3R was 3, the voltage was 25.0 V, air-flow was 0.04 m3 x h(-1), and electrode span was 3.0 cm, the decolorization efficiency of Acid Red 3R can reach 97.6%. The removal rate of color had still about 80% in this electro-chemical oxidation system, after HPW/gamma-Al2O3 was used for 10 times, but active component loss existed. The interim product was analyzed by means of Vis-UV absorption spectrum. It shows that the conjugated structure of dye is destroyed primarily. PMID:23745400

Yue, Lin; Wang, Kai-Hong; Guo, Jian-Bo; Yang, Jing-Liang; Liu, Bao-You; Lian, Jing; Wang, Tao

2013-03-01

250

A theoretical study of H2 dissociation on (3×3)R30°CO/Ru(0001)  

NASA Astrophysics Data System (ADS)

We have studied the influence of preadsorbed CO on the dissociative adsorption of H2 on Ru(0001) with density functional theory calculations. For a coverage of 1/3 ML CO, we investigated different possible reaction paths for hydrogen dissociation using nudged elastic band and adaptive nudged elastic band calculations. One reaction path was studied in detail through an energy decomposition and molecular orbital type of analysis. The minimum barrier for H2 dissociation is found to be 0.29 eV. At the barrier the H-H bond is hardly stretched. Behind this barrier a molecular chemisorption minimum is present. Next, the molecule overcomes a second barrier, with a second local chemisorption minimum behind it. To finally dissociate to chemisorbed atoms, the molecule has to overcome a third barrier. To move along the reaction path from reactants to products, the hydrogen molecule needs to rotate, and to significantly change its center-of-mass position. The procedure of mapping out reaction paths for H2 reacting on low-index surfaces of bare metals (computing two-dimensional elbow plots for fixed impact high-symmetry sites and H2 orientations parallel to the surface) does not work for H2+CO/Ru. The first barrier in the path is recovered, but the features of the subsequent stretch to the dissociative chemisorption minimum are not captured, because the molecule is not allowed to change its center-of-mass position or to rotate. The dissociative chemisorption of H2 on CO/Ru(0001) is endoergic, in contrast to the case of H2 on bare Ru(0001). The zero-point energy corrected energies of molecularly and dissociatively chemisorbed H2 are very close, suggesting that it may be possible to detect molecularly chemisorbed H2 on (3×3)R30°CO/Ru(0001). The presence of CO on the surface increases the barrier height to dissociation compared with bare Ru(0001). Based on an energy decomposition and molecular orbital analysis we attribute the increase in the barrier height mainly to an occupied-occupied interaction between the bonding H2 ?g orbital and the (surface-hybridized) CO 1? orbitals, i.e., to site blocking. There is a small repulsive contribution to the barrier from the interaction between the H2 molecule and the Ru part of the CO covered Ru surface, but it is smaller than one might expect based on the calculations of H2 interacting with a clean Ru surface, and on calculations of H2 interacting with the CO overlayer only. Actually, the analysis suggests that the Ru surface as a subsystem is (slightly) more reactive for the reaction path studied with CO preadsorbed on it than without it. Thus, the results indicate that the influence of CO on H2 dissociation on Ru is not only a simple site-blocking effect, the electronic structure of the underlying Ru is changed.

Groot, I. M. N.; Juanes-Marcos, J. C.; Olsen, R. A.; Kroes, G. J.

2010-04-01

251

A multipurpose broad host range cloning vector and its use to characterise an extracellular protease gene of Xanthomonas campestris pathovar campestris  

Microsoft Academic Search

A multipurpose broad host range plasmid, pIJ3200, was constructed by inserting the polylinker-containing 445 by PvuII fragment of Bluescript M13 into the EcoRI site of the cosmid pLAFR1. Using this vector a protease gene of Xanthomonas campestris pathovar campestris, previously cloned in the recombinant plasmid pIJ3070, was located by deletion to a 2.2 kb DNA region. Sequencing of the protease

Yu-Ning Liu; Ji-Liang Tang; Belinda R. Clarke; J. Maxwell Dow; Michael J. Daniels

1990-01-01

252

Multi-destination and multi-purpose trip effects in the analysis of the demand for trips to a remote recreational site.  

PubMed

One of the basic assumptions of the travel cost method for recreational demand analysis is that the travel cost is always incurred for a single purpose recreational trip. Several studies have skirted around the issue with simplifying assumptions and dropping observations considered as nonconventional holiday-makers or as nontraditional visitors from the sample. The effect of such simplifications on the benefit estimates remains conjectural. Given the remoteness of notable recreational parks, multi-destination or multi-purpose trips are not uncommon. This article examines the consequences of allocating travel costs to a recreational site when some trips were taken for purposes other than recreation and/or included visits to other recreational sites. Using a multi-purpose weighting approach on data from Gros Morne National Park, Canada, we conclude that a proper correction for multi-destination or multi-purpose trip is more of what is needed to avoid potential biases in the estimated effects of the price (travel-cost) variable and of the income variable in the trip generation equation. PMID:19184577

Martínez-Espiñeira, Roberto; Amoako-Tuffour, Joe

2009-01-31

253

Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells.  

PubMed

Caveolin-1 (Cav-1) regulates agonist-induced Ca(2+) entry in endothelial cells; however, how Cav-1 regulates this process is poorly understood. Here, we describe that Cav-1 scaffold domain (NH(2)-terminal residues 82-101; CSD) interacts with transient receptor potential canonical channel 1 (TRPC1) and inositol 1,4,5-trisphosphate receptor 3 (IP(3)R3) to regulate Ca(2+) entry. We have shown previously that the TRPC1 COOH-terminal residues 781-789 bind to CSD. In the present study, we show that the TRPC1 COOH-terminal residues 781-789 truncated (TRPC1-CDelta781-789) mutant expression abolished Ca(2+) store release-induced Ca(2+) influx in human dermal microvascular endothelial cell line (HMEC) and human embryonic kidney (HEK-293) cells. To understand the basis of loss of Ca(2+) influx, we determined TRPC1 binding to IP(3)R3. We observed that the wild-type (WT)-TRPC1 but not TRPC1-CDelta781-789 effectively interacted with IP(3)R3. Similarly, WT-TRPC1 interacted with Cav-1, whereas TRPC1-CDelta781-789 binding to Cav-1 was markedly suppressed. We also assessed the direct binding of Cav-1 with TRPC1 and observed that the WT-Cav-1 but not the Cav-1DeltaCSD effectively interacted with TRPC1. Since the interaction between TRPC1 and Cav-1DeltaCSD was reduced, we measured Ca(2+) store release-induced Ca(2+) influx in Cav-1DeltaCSD-transfected cells. Surprisingly, Cav-1DeltaCSD expression showed a gain-of-function in Ca(2+) entry in HMEC and HEK-293 cells. We observed a similar gain-of-function in Ca(2+) entry when Cav-1DeltaCSD was expressed in lung endothelial cells of Cav-1 knockout mice. Immunoprecipitation results revealed that WT-Cav-1 but not Cav-1DeltaCSD interacted with IP(3)R3. Furthermore, we observed using confocal imaging the colocalization of IP(3)R3 with WT-Cav-1 but not with Cav-1DeltaCSD on Ca(2+) store release in endothelial cells. These findings suggest that CSD interacts with TRPC1 and IP(3)R3 and thereby regulates Ca(2+) store release-induced Ca(2+) entry in endothelial cells. PMID:19052258

Sundivakkam, Premanand C; Kwiatek, Angela M; Sharma, Tiffany T; Minshall, Richard D; Malik, Asrar B; Tiruppathi, Chinnaswamy

2008-12-03

254

From Tri?O?Acetyl?D?Glucal to (2R,3R,5R)?2,3?Diazido?5?Hydroxycyclohexanone Oxime  

Microsoft Academic Search

Methyl 3?azido?2,3?dideoxy??\\/??D?arabino? and ??\\/??D?ribo?hexopyranosides were transformed into 6?iodo analogues via p?tolylsulfonyl compounds. Elimination of hydrogen iodide from 6?iodo glycosides provided methyl 4?O?acetyl?3?azido?2,3,6?trideoxy??? and ???D?threo?hex?5?eno?pyranosides or 3?azido?4?O?p?tolylsulfonyl?2,3,6?trideoxy???D?threo? and ???D?erythro?hex?5?eno?pyranosides. Ferrier's carbocyclization of 4?O?acetyl?3?azido?2,3,6?trideoxy??? and ???D?threo?hex?5?eno?pyranosides gave (2S,3R,5R)?2?acetoxy?3?azido?5?hydroxycyclohexanone, which was converted into oxime. The 2?OAc group in oxime was substituted by azide ion to yield (2R,3R,5R)?2,3?diazido?5?hydroxycyclohexanone oxime. The configuration and conformation of

Beata Liberek; Aleksandra D?browska; Ryszard Frankowski; Zygfryd Smiatacz

2004-01-01

255

A SURFACE CRYSTALLOGRAPHY STUDY BY DYNAMICAL LEED OF THE (sqrt3xsqrt3)R30o CO STRUCTURE ON THE Rh(111) CRYSTAL SURFACE  

SciTech Connect

The atomic positions of the Rh(111) + ({radical}3 x {radical}3)R30{sup o} CO and CO{sub 2} surfaces are analyzed by dynamical LEED. The Rh(111) + ({radical}3 x {radical}3)R30{sup o} CO and CO{sub 2} systems produce identical I-V curves, confirming the dissociation of CO{sub 2} to CO on this surface. The adsorbed CO is found to stand perpendicular to the surface with the carbon end down at an atop site (that is, terminally bonded). The CO overlayer spacings are d{sub RhC} = 1.95 {+-} 0.1 {angstrom} and d{sub CD} = 1.07 {+-} 0.1 {angstrom}. This geometry yields a Zanazzi-Jona R-factor of 0.40 and a Pendry R-factor of 0.50.

Koestner, R.J.; Van Hove, M.A.; Somorjai, G.A.

1980-09-01

256

Environmental factors influencing survival of threespine stickleback (Gasterosteus aculeatus) in a multipurpose constructed treatment wetland in southern California.  

PubMed

Survival of the threespine stickleback, Gasterosteus aculeatus, differed among marshes in a demonstration 9.9-ha multipurpose constructed treatment wetland designed to improve the quality of secondary-treated municipal wastewater in southern California. At a mean loading rate of 3.3 kg NH4-N ha(-1) d(-1) (6 kg total N ha(-1) d(-1)), the suitability of the wetland to support a population of sticklebacks was estimated to be low. The development of potentially toxic levels of un-ionized ammonia, particularly during periods when pH increased concomitantly with oxygen generation by phytoplankton biomass > 300 mg chlorophyll a liter(-1), and disinfection by-products were associated with lowered survivorship of sentinel fish. Moreover, the high oxygen demand from nitrification of NH4-N created daily periods of low dissolved oxygen concentration (6-16 h at < 2 mg liter(-1)) in the open water areas of the shallow marshes. Low dissolved oxygen concentration in open water zones of the seven marshes during a part of each day and persistent anaerobic conditions in the emergent vegetation rendered the majority of the wetland's substrate surface unavailable for successful reproduction by sticklebacks. The potential sites for Gasterosteus to replace mosquitofish, Gambusia affinis and G. holbrooki, as a biological control agent against mosquitoes are probably limited to comparatively cool-water habitats with high water quality, such as riverine wetlands. PMID:17633430

Walton, William E; Wirth, Margaret C; Workman, Parker D

2007-06-01

257

Full-scale prototype of the circular track detector for the multipurpose detector facility at the NICA acceleration complex  

NASA Astrophysics Data System (ADS)

The development of the NICA heavy ion collider, which is now under way, assumes the development of a Multipurpose Detector (MPD), including an end-cap tracker (EC) (which can be a wheel-type tracker based on thin-wall drift tubes (straws) similar to the inner detector of the transition radiation tracker (TRT) in the ATLAS experiment). The identical front and back tracker modules mounted behind the TPC are to ensure the detection of Au-Au ion collision products in the pseudorapidity range from 1.4 to 2.1 with good track parameters of reconstructed events. Each module will contain 60 circular straw planes and maximum straw occupancy will be no higher than 0.2 particle per collision. The NICA EC is substantially different from its analogue and requires a certain amount of R&D. The first results from applying new technology to make a full-scale prototype of the circular EC detector for NICA are presented.

Berezin, G. S.; Boguslavskii, I. V.; Grigalashvili, N.; Davkov, V. I.; Davkov, K. I.; Zhukov, I. A.; Zinchenko, A. I.; Kekelidze, V. D.; Kekelidze, G. D.; Lysan, V. M.; Myalkovskiy, V. V.; Peshekhonov, V. D.; Topilin, N. D.; Shabunov, A. V.; Cholakov, V. D.

2012-03-01

258

MGEANT-A generic multi-purpose Monte-Carlo simulation package for gamma-ray experiments  

NASA Astrophysics Data System (ADS)

We present a generic multi-purpose Monte-Carlo simulation package, based on GEANT and the CERN Program Library, which is appropriate for gamma-ray astronomy, and allows the rapid prototyping of a wide variety of detector systems. Instrument specific geometry and materials data can simply be supplied via input files, and are independent of the main code. The user can select from a standard set of event generators and beam options (implemented as ``plug-ins'') which would be needed in an astrophysical or instrument calibration context. The philosophy of this approach is to facilitate the implementation of new software add-ons and changes in the instrumental setup. This is especially useful for projects which involve a large group of developers and collaborators. MGEANT has been successfully used to perform background calculations and to generate the instrument response for the WIND/TGRS instrument, and is currently being used to study the background, sensitivity, response, and imaging capabilities of the INTEGRAL/SPI.

Seifert, Helmut; Naya, Juan E.; Sturner, Steven J.; Teegarden, Bonnard J.

1997-05-01

259

Design and investigations of the superconducting magnet system for the multipurpose superconducting electron cyclotron resonance ion source  

SciTech Connect

The production of intense beams of heavy ions with electron cyclotron resonance ion sources (ECRIS) is an important request at many accelerators. According to the ECR condition and considering semi-empirical scaling laws, it is essential to increase the microwave frequency together with the magnetic flux density of the ECRIS magnet system. A useful frequency of 28 GHz, therefore, requires magnetic flux densities above 2.2 T implying the use of superconducting magnets. A cooperation of European institutions initiated a project to build a multipurpose superconducting ECRIS (MS-ECRIS) in order to achieve an increase of the performances in the order of a factor of ten. After a first design of the superconducting magnet system for the MS-ECRIS, the respective cold testing of the built magnet system reveals a lack of mechanical performance due to the strong interaction of the magnetic field of the three solenoids with the sextupole field and the magnetization of the magnetic iron collar. Comprehensive structural analysis, magnetic field calculations, and calculations of the force pattern confirm thereafter these strong interactions, especially of the iron collar with the solenoidal fields. The investigations on the structural analysis as well as suggestions for a possible mechanical design solution are given.

Tinschert, K.; Lang, R.; Maeder, J.; Rossbach, J.; Spaedtke, P. [GSI Helmholtzzentrum fuer Schwerionenforschung, Darmstadt (Germany); Komorowski, P.; Meyer-Reumers, M.; Krischel, D.; Fischer, B. [Bruker Advanced Supercon GmbH, Bergisch Gladbach (Germany); Ciavola, G.; Gammino, S.; Celona, L. [Istituto Nazionale Fisica Nucleare - Laboratori Nazionali del Sud, Catania (Italy)

2012-02-15

260

Effective information management in forestry: An application to fuel wood and multi-purpose tree species research in Central America  

SciTech Connect

The main goals of this study were: (a) the development of a methodology to collect and organize silvicultural and environmental information in forestry research on fuel wood and multi-purpose tree species (MPTS) production, and (b) the design of a Management Information System (MIS) to supply decision-support for different end-users. This study was supported by a project of USAID for fuel wood research in six Central American countries. Uniform standards and guidelines for implementing fuel wood and MPTS experiments were established in order to permit global exchange and transfer of information on MPTS research. These standards for data collection and field measurements, and minimum data sets were developed in coordination with scientists to ensure the collection of useful information and to gain acceptance of these standards. The minimum data sets were developed to reflect what can be achieved at a reasonable logistic expense with an acceptable degree of consistency. Establishment of MPTS information data bases will permit improvement in all phases of forest management, including seed procurement and species selection for environmental zones.

Ugalde Arias, L.A.

1988-01-01

261

Total synthesis of (2 S,3 R,5 S)-(?)-2,3-dihydroxytetradecan-5-olide, a new biologically active ?-lactone produced by Seiridium unicorne  

Microsoft Academic Search

The first total synthesis of (2S,3R,5S)-(?)-2,3-dihydroxytetradecan-5-olide (1), a new biologically active ?-lactone produced by Seiridium unicome, was accomplished from (R)-malic acid. In connection with the determination of the absolute configuration of 1, (2R,3S,5R)-(+)-2,3-dihydroxytetradecan-5-olide (ent-1) was also synthesized from D-glucose.

Hiroaki Toshima; Hiroji Sato; Akitami Ichihara

1999-01-01

262

Hydrogen adsorption on the Pt(111)( 3 × 3 ) R30° Sn surface alloy studied by high resolution core level photoelectron spectroscopy  

Microsoft Academic Search

Investigation of the clean and atomic hydrogen covered Pt(111)(3 × 3)R30°-Sn surface alloy has been carried out using high resolution core level photoelectron spectroscopy. The Pt 4f72 spectrum recorded from the clean surface alloy shows a single surface peak shifted ?0.25 eV relative to the bulk. Its interpretation by means of a thermodynamical model using Born-Haber cycles confirms the surface

E. Janin; M. Björkqvist; T. M. Grehk; M. Göthelid; C.-M. Pradier; U. O. Karlsson; A. Rosengren

1996-01-01

263

Optical Resolution of Racemic Alcohols via Diastereoisomeric Supramolecular Compound Formation with O, O?-Dibenzoyl-(2 R,3 R)-tartaric Acid  

Microsoft Academic Search

O,O?-Dibenzoyl-(2R,3R)-tartaric acid (DBTA) forms a hydrogen bonded supramolecular compound with alcohols. The supramolecular compound formation is enantioselective for a large number of chiral alcohols, therefore DBTA can be used as resolving agent, also for compounds having no basic group. The condition of the complex formation is that the guest molecule should contain a proton donating group and a fitting aliphatic

Csaba Kassai; Zoltán Juvancz; József Bálint; Elemér Fogassy; Dávid Kozma

2000-01-01

264

Synthesis of 3?O???D?Glucopyranosyl?(3R)?hydroxybutanolide (Kinsenoside) and 3?O???D?Glucopyranosyl?(3S)?hydroxybutanolide (Goodyeroside A)  

Microsoft Academic Search

The first synthesis of 3?O???D?glucopyranosyl?(3R)?hydroxybutanolide (Kinsenoside) and 3?O???D?glucopyranosyl?(3S)?hydroxybutanolide (Goodyeroside A) is described. The diastereomers of the aglycon in 2?O???D?gulucopyranosyl?1,2,4?butanetriol derivatives, which were separable precursors of Kinsenoside and Goodyeroside A, were synthesized from optically nonactive 1,2,4?butanetriol and ??D?glucopyranosyl trichloroacetimidate in excellent yields.

Katsuhiko Suzuki; Nobuyuki Suzuki; Masanori Yamaura; Toyokichi Yoshizawa

2005-01-01

265

Phosphatidylinositol 3-kinase p85? regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population  

Microsoft Academic Search

Aims\\/hypothesis  Phosphatidylinositol 3-kinase (PI3K) couples the leptin and insulin signalling pathways via the insulin receptor substrates IRS1 and IRS2. Hence, defective activation of PI3K could be a novel mechanism of peripheral leptin or insulin resistance. We investigated associations of tagging single-nucleotide polymorphisms (tSNPs) in the PI3K p85? regulatory subunit gene PIK3R1 with anthropometry, leptin, body fat and insulin sensitivity in a

Y. Jamshidi; H. Snieder; X. Wang; M. J. Pavitt; T. D. Spector; N. D. Carter; S. D. O’Dell

2006-01-01

266

The metabotropic glutamate receptor agonist 1 S,3 R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures  

Microsoft Academic Search

The potential toxic effects of the metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) and its interactions with the N-methyl-d-aspartate (NMDA) receptor were studied in hippocampal brain slice cultures, using densitometric measurements of the cellular uptake of propidium iodide (PI) to quantify neuronal degeneration. Cultures exposed to ACPD, showed a concentration (2–5 mM) and time (1–4 days) dependent increase in PI

Morten Blaabjerg; Bjarne W. Kristensen; Christian Bonde; Jens Zimmer

2001-01-01

267

SHP2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women  

Microsoft Academic Search

Insulin regulates apoB metabolism via activation of PI3K or regulation of MTP via MAPK\\/ERK signalling. SHP-2 enhances both pathways through increased IRS-1 phosphorylation. We hypothesized that variants in the SHP-2 gene PTPN11 and PI3K p85alpha subunit gene PIK3R1 may influence fasting levels of plasma apoB and\\/or LDL cholesterol. We tested association of tagging SNPs (tSNPs) in each gene with serum

Y. Jamshidi; S. B. Gooljar; H. Snieder; X. Wang; D. Ge; R. Swaminathan; T. D. Spector; S. D. O’Dell

2007-01-01

268

Serum TSH, T4, T3, FT4, FT3, rT3, and TBG in Youngsters with Non-Ketotic Insulin-Dependent Diabetes mellitus  

Microsoft Academic Search

Several parameters of thyroid function were studied in 112 non-ketoacidotic youngsters with insulin-dependent diabetes mellitus (IDDM). Levels of thyroxine (T4), reverse triiodothyronine (rT3), thyroxine-binding globulin (TBG) and T3 were lower than in controls, whereas FT4, and FT3 were normal. T4 levels in IDDM patients were positively related to T3, rT3 and TBG, and inversely related to haemoglobin Ai (HbA1. However,

Sergio Bernasconi; Maurizio Vanelli; Giuseppe Nori; Maria Francesca Siracusano; Clementina Marcellini; Anna Butturini; Filippo De Luca

1984-01-01

269

Reconstruction of the 6H–SiC(0001) ?3×?3-R30° surfaces by adsorption of hydrogen in ultra high vacuum  

Microsoft Academic Search

Reconstruction of the 6H–SiC(0001)?3×?3-R30° surfaces in ultra high vacuum (UHV) has been studied by rocking curves of reflection high energy electron diffraction (RHEED) intensities and Auger electron spectroscopy (AES). It is found that the silicon rich ?3×?3 surface is unstable in UHV. This ?3×?3 surface transforms into the carbon rich 1×1 surface in rather short time. The phase transition is

Yoshiyuki Hisada; Tomohiro Aoyama; Shinichi Mukainakano; Ayahiko Ichimiya

2002-01-01

270

The ( 3 × 3 )R30° reconstruction on hexagonal 6H–SiC( 0 0 0 1 ) surface with and without a Si flux  

Microsoft Academic Search

The (3×3)R30° reconstruction on hexagonal 6H–SiC(0001) surface and its properties were studied by using reflection high-energy electron diffraction (RHEED) and RHEED multislice dynamical calculations. A Si coverage of 1\\/3 monolayer occupying the threefold-symmetric T4 or H3 sites develops upon a lower Si flux and\\/or at a higher annealing temperature and\\/or upon a longer time annealing. However, Si trimers centered on

Yujie Han; Tomohiro Aoyama; Ayahiko Ichimiya; Yoshiyuki Hisada; Shinichi Mukainakano

2001-01-01

271

Ace I\\/d And Actn3 R577x Polymorphism In Elite Athletes: 886 Board #108 10:30 AM ??? 12:00 PM  

Microsoft Academic Search

Increasing evidence has shown that genetic traits play a role in the speed and endurance performance of athletes. Among these genetic traits, genes involved in the regulation of cardiovascular (e.g. angiotensin-converting-enzyme, ACE) and muscular (e.g. ?-actinin-3, ACTN3) physiology have been speculated as the potential candidates. Recent studies have suggested that ACE I\\/D and ACTN3 R577X polymorphism might be associated with

Li-Ling Chiu; Ling-Ling Hsieh; Ke-Tien Yen; Sandy S. Hsieh

2005-01-01

272

Microstructure and physical properties of superionic eutectic composites of the LiF–RF 3 (R=rare earth element) system  

Microsoft Academic Search

For the eutectic composites of the LiF–RF3 (R=rare earth element, Y) system, which were prepared from the melt, the relations between (1) the electrical properties (fast fluoride ion conduction and dielectric response) of the composites and those of both corresponding single phases, (2) the composition, the preparation technique, the microstructure and the electrical properties of the composites, are examined. In

V Trnovcová; P. P Fedorov; ? Bárta; V Labaš; V. A Meleshina; B. P Sobolev

1999-01-01

273

Novel 1D coordination polymer {l_brace}Tm(Piv){sub 3{r_brace}n}: Synthesis, structure, magnetic properties and thermal behavior  

SciTech Connect

The new 1D coordination polymer {l_brace}Tm(Piv){sub 3{r_brace}n} (1), where Piv=OOCBu{sup t-}, was synthesized in high yield (>95%) by the reaction of thulium acetate with pivalic acid in air at 100 Degree-Sign S. According to the X-ray diffraction data, the metal atoms in compound 1 are in an octahedral ligand environment unusual for lanthanides. The magnetic and luminescence properties of polymer 1, it's the solid-phase thermal decomposition in air and under argon, and the thermal behavior in the temperature range of -50 Horizontal-Ellipsis +50 Degree-Sign S were investigated. The vaporization process of complex 1 was studied by the Knudsen effusion method combined with mass-spectrometric analysis of the gas-phase composition in the temperature range of 570-680 K. - Graphical Abstract: Novel 1D coordination polymer {l_brace}Tm(Piv){sub 3{r_brace}n} was synthesized and studied by X-ray diffraction. The magnetic, luminescence properties, the thermal behavior and the volatility for the compound {l_brace}Tm(Piv){sub 3{r_brace}n} were investigated. Black-Small-Square Highlights: Black-Right-Pointing-Pointer We synthesized the coordination polymer {l_brace}Tm(Piv){sub 3{r_brace}n}. Black-Right-Pointing-Pointer Tm atoms in polymer have the coordination number 6. Black-Right-Pointing-Pointer Polymer exhibits blue-color emission at room temperature. Black-Right-Pointing-Pointer Polymer shows high thermal stability and volatility. Black-Right-Pointing-Pointer Polymer has no phase transitions in the range of -50 Horizontal-Ellipsis +50 Degree-Sign S.

Fomina, Irina, E-mail: fomina@igic.ras.ru [N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Prosp. 31, 119991 Moscow, GSP-1 (Russian Federation); Dobrokhotova, Zhanna; Aleksandrov, Grygory [N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Prosp. 31, 119991 Moscow, GSP-1 (Russian Federation); Emelina, Anna; Bykov, Mikhail [Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, 119991 Moscow, GSP-1 (Russian Federation); Malkerova, Irina [N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Prosp. 31, 119991 Moscow, GSP-1 (Russian Federation); Bogomyakov, Artem [International Tomography Center, Siberian Branch of the Russian Academy of Sciences, Institutskaya Str. 3a, 630090 Novosibirsk (Russian Federation); Puntus, Lada [Kotel'nikov Institute of Radioengineering and Electronics, Russian Academy of Sciences, Mokhovaya Str. 11-7, 125009 Moscow (Russian Federation); Novotortsev, Vladimir; Eremenko, Igor [N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninsky Prosp. 31, 119991 Moscow, GSP-1 (Russian Federation)

2012-01-15

274

Is there an association between ACTN3 R577X polymorphism and muscle power phenotypes in young, non-athletic adults?  

PubMed

We investigated the association between ACTN3 R577X polymorphism and jumping (vertical squat and counter-movement jump tests) and sprint ability (30?m dash) in non-athletic, healthy young adults [N=284 (217 male), mean (SD) age: 21 (2) years]. We analyzed the differences in the study phenotypes among ACTN3 R577X genotypes by one-way analysis of covariance before and after adjusting for sex, age, weight and height (confounders). We also compared the genotype and allele frequencies between those with the best and worst results in the aforementioned tests (?90th vs <90th of the sex-specific percentile, respectively). We used logistic regression to calculate the odds ratio (OR) for having the best performance. We did not observe a significant association between ACTN3 R577X genotypes and the study phenotypes before and after adjusting for potential confounders, nor after analyzing males and females separately. We did not observe significant differences in genotype frequencies between those with the best or the worst performance. The OR for an individual with the RR genotype to be in the top 10 percentile was <1.00 for jump tests and <1.015 for sprint tests (all P>0.05). In summary, ?-actinin-3 deficiency does not negatively influence the ability to generate explosive leg muscle power in a young non-athletic population. PMID:19807896

Santiago, C; Rodríguez-Romo, G; Gómez-Gallego, F; González-Freire, M; Yvert, T; Verde, Z; Naclerio, F; Altmäe, S; Esteve-Lanao, J; Ruiz, J R; Lucia, A

2010-10-01

275

Allelic Variants of Melanocortin 3 Receptor Gene (MC3R) and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat Diets  

PubMed Central

Introduction The melanocortin system plays an important role in energy homeostasis. Mice genetically deficient in the melanocortin-3 receptor gene have a normal body weight with increased body fat, mild hypophagia compared to wild-type mice. In humans, Thr6Lys and Val81Ile variants of the melanocortin-3 receptor gene (MC3R) have been associated with childhood obesity, higher BMI Z-score and elevated body fat percentage compared to non-carriers. The aim of this study is to assess the association in adults between allelic variants of MC3R with weight loss induced by energy-restricted diets. Subjects and Methods This research is based on the NUGENOB study, a trial conducted to assess weight loss during a 10-week dietary intervention involving two different hypo-energetic (high-fat and low-fat) diets. A total of 760 obese patients were genotyped for 10 single nucleotide polymorphisms covering the single exon of MC3R gene and its flanking regions, including the missense variants Thr6Lys and Val81Ile. Linear mixed models and haplotype-based analysis were carried out to assess the potential association between genetic polymorphisms and differential weight loss, fat mass loss, waist change and resting energy expenditure changes. Results No differences in drop-out rate were found by MC3R genotypes. The rs6014646 polymorphism was significantly associated with weight loss using co-dominant (p?=?0.04) and dominant models (p?=?0.03). These p-values were not statistically significant after strict control for multiple testing. Haplotype-based multivariate analysis using permutations showed that rs3827103–rs1543873 (p?=?0.06), rs6014646–rs6024730 (p?=?0.05) and rs3746619–rs3827103 (p?=?0.10) displayed near-statistical significant results in relation to weight loss. No other significant associations or gene*diet interactions were detected for weight loss, fat mass loss, waist change and resting energy expenditure changes. Conclusion The study provided overall sufficient evidence to support that there is no major effect of genetic variants of MC3R and differential weight loss after a 10-week dietary intervention with hypo-energetic diets in obese Europeans.

Santos, Jose L.; De la Cruz, Rolando; Holst, Claus; Grau, Katrine; Naranjo, Carolina; Maiz, Alberto; Astrup, Arne; Saris, Wim H. M.; MacDonald, Ian; Oppert, Jean-Michel; Hansen, Torben; Pedersen, Oluf; Sorensen, Thorkild I. A.; Martinez, J. Alfredo

2011-01-01

276

Managing runoff and flow pathways in a small rural catchment to reduce flood risk with other multi-purpose benefits  

NASA Astrophysics Data System (ADS)

From 2000 to 2009 there have been a high number of flood events throughout Northern Europe. Meanwhile, there is a demand for land in which to construct homes and businesses on, which is encroaching on land which is prone to flooding. Nevertheless, flood defences usually protect us from this hazard. However, the severity of floods and this demand for land has increased the number of homes which have been flooded in the past ten years. Public spending on flood defences can only go so far which targets the large populations first. Small villages and communities, where in many cases normal flood defences are not cost effective, tend to wait longer for flood mitigation strategies. The Belford Burn (Northumberland, UK) catchment is a small rural catchment that drains an area of 6 km2. It flows through the village of Belford. There is a history of flooding in Belford, with records of flood events dating back to 1877. Normal flood defences are not suitable for this catchment as it failed the Environment Agency (EA) cost benefit criteria for support. There was a desire by the local EA Flood Levy Team and the Northumbria Regional Flood Defence Committee at the Environment Agency to deliver an alternative catchment-based solution to the problem. The EA North East Flood Levy team and Newcastle University have created a partnership to address the flood problem using soft engineered runoff management features. Farm Integrated Runoff Management (FIRM) plans manage flow paths directly by storing slowing and filtering runoff at source on farms. The features are multipurpose addressing water quality, trapping sediment, creating new habitats and storing and attenuating flood flow. Background rainfall and stream stage data have been collected since November 2007. Work on the first mitigation features commenced in July 2008. Since that date five flood events have occurred in the catchment. Two of these flood events caused widespread damage in other areas of the county. However, in Belford only two houses were flooded. Data from the catchment and mitigation features showed that the defence measures resulted in an increase in travel time of the peak and attenuated high flows which would have usually travelled quickly down the channel to the village. For example, the pilot feature appears to have increased the travel time of a flood peak at the top of the catchment from 20 minutes to 35 minutes over a 1 km stretch of channel. There are currently ten active mitigation features present in the catchment. More features are planned for construction this year. Early data from the catchment indicates that the runoff attenuation features are having an impact on reducing flood flows in the channel and also slowing down the flood peak. At the same time the multi-purpose aspects of the features are apparent.

Wilkinson, Mark; Welton, Phil; Kerr, Peter; Quinn, Paul; Jonczyk, Jennine

2010-05-01

277

Multipurpose superconducting electron cyclotron resonance ion source, the European roadmap to third-generation electron cyclotron resonance ion sources  

SciTech Connect

The major infrastructures of nuclear physics in Europe adopted the technology of electron cyclotron resonance (ECR) ion sources for the production of heavy-ion beams. Most of them use 14 GHz electron cyclotron resonance ion sources (ECRISs), except at INFN-LNS, where an 18 GHz superconducting ECRIS is in operation. In the past five years it was demonstrated, in the frame of the EU-FP5 RTD project called ''Innovative ECRIS,'' that further enhancement of the performances requires a higher frequency (28 GHz and above) and a higher magnetic field (above 2.2 T) for the hexapolar field. Within the EU-FP6 a joint research activity named ISIBHI has been established to build by 2008 two different ion sources, the A-PHOENIX source at LPSC Grenoble, reported in another contribution, and the multipurpose superconducting ECRIS (MS-ECRIS), based on fully superconducting magnets, able to operate in High B mode at a frequency of 28 GHz or higher. Such a development represents a significant step compared to existing devices, and an increase of typically a factor of 10 for the intensity is expected (e.g., 1 emA for medium charge states of heavy ions, or hundreds of e{mu}A of fully stripped light ions, or even 1 e{mu}A of charge states above 50{sup +} for the heaviest species). The challenging issue is the very high level of magnetic field, never achieved by a minimum B trap magnet system; the maximum magnetic field of MS-ECRIS will be higher than 4 or 5 T for the axial field and close to 2.7 T for the hexapolar field. The detailed description of the MS-ECRIS project and of its major constraints will be given along with the general issues of the developments under way.

Ciavola, G.; Gammino, S.; Celona, L.; Torrisi, L.; Passarello, S.; Ando, L.; Cavenago, M.; Galata, A.; Spaedtke, P.; Tinschert, K.; Lang, R.; Iannucci, R.; Leroy, R.; Barue, C.; Hitz, D.; Seyfert, P.; Koivisto, H.; Suominen, P.; Tarvainen, O.; Beijers, H. [Istituto Nazionale Fisica Nucleare-Laboratori Nazionali del Sud (INFN-LNS), Via S. Sofia 62, 95123 Catania (Italy) and INFN-Laboratori Nazionali di Legnaro (INFN-LNL), 35020 Legnaro (Italy); Gesellschaft fuer Schwerionenforschung mbH (GSI), 64291 Darmstadt (Germany); Grand Accelerateur National d'Ions Lourds (GANIL), 14076 Caen (France); CEA-DRFMC-SBT, 38054 Grenoble (France); Department of Physics, University of Jyvaeskylae (JYFL), 40014 Jyvaeskylae (Finland); Kernfysisch Versneller Instituut (KVI), 9747 AA Groningen (Netherlands); Svedberg Laboratory (TSL), 75121 Uppsala (Sweden); CERN AB Department, CERN CH-1211 Geneva (Switzerland); Hahn Meitner Institut Berlin GmbH (HMI), 14109 Berlin (Germany); National Institute of Physics and Nuclear Engineering (NIPNE), MG-6, Bucharest-Magurele (Romania)] (and others)

2006-03-15

278

Preparation and evaluation of 3-methyl isomers of 15-(p-iodophenyl)-3-methylpentadecanoic acid (BMIPP): 3R-BMIPP shows greater heart uptake than 3S-BMIPP in rats  

SciTech Connect

Iodine-123 racemic (3-R,S) BMIPP is of widespread interest for evaluation of myocardial viability. To evaluate the effects of the asymmetric C-3 center of BMIPP on heart uptake/clearance we have resolved and characterized 3R- and 3S-BMIPP (H-1 and C-13 NMR, MS, HPLC, [{alpha}], m.p.) and evaluated the radioiodinated isomers in rats. A thiophene {open_quotes}template{close_quotes} approach using ethyl 3R-methylglutarate was used to synthesize the authentic 3R-BMPPA substrate (mp 41-42 {degrees}C, [{alpha}] + 1.45 {degrees}). Reaction of racemic 3-R, S-BNPPA with S-(-)-{alpha}-methylbenzylamine gave the diastereomeric amides, separated by TLC, column or HPLC. The more polar isomer was identical to the amide prepared from the 3R-isomer. HCI cleavage of the purified diastereomers provided 3R- and 3S-BMPPA (mp 40-41 {degrees}C, [{alpha}] - 3.90 {degrees}). Iodination (TTFAA/KI) gave 3R-BMIPP (mp 51-52 {degrees}C, [{alpha}] + 0.74 {degrees}) and 3S-BMIPP (mp 45-46 {degrees}C, [{alpha}] - 1.67 {degrees}), which formed amides identical with the two amides separated from the 3-R, S-BMIPP amide mixture. A [I-125]-3R-BMIPP and [I-131]-3S-BMIPP mixture was administered to groups of fasted rats (n = 5/group) sacrificed at 5, 15, 60 and 180 minutes. While blood levels and uptake and clearance from liver, lungs and kidney were nearly identical for both isomers, 3R-BMIPP had higher heart uptake at all periods evaluated (%ID/gram, i.e., 15 min: 3R = 5.25 {plus_minus} 0.77, 3S= 4.51 {plus_minus} 0.50; 180 min: 3R = 2.31 {plus_minus} 0.51, 3S = 1.98 {plus_minus} 0.26), suggesting that transport into the myocytes is different for the isomers. Higher heart uptake suggests that the 3R-BMIPP isomer should be further evaluated.

Knapp, F.F.R. Jr.; Lin, Q.; Luo, H. [Oak Ridge National Lab., TN (United States)] [and others

1996-05-01

279

Molecular insights into the D1R agonist and D2R/D3R antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations.  

PubMed

(-)-Stepholidine (l-SPD), an active ingredient of the Chinese herb Stephania, is the first compound found to have a dual function as a dopamine receptor D1 agonist and D2 antagonist. The preliminary dynamical behaviors of D1R and D2R and their interaction modes with l-SPD were investigated in our previous study. Recently, the pharmacological effect of l-SPD on D3R was elucidated as an antagonist. This new discovery in combination with the explosion of structural biology in GPCR superfamily prompted us to perform a more comprehensive investigation on the special pharmacological profiles of l-SPD on dopamine receptors. In this study, the integration of homology modeling, automated molecular docking, and MD simulations was used to probe the agonistic and antagonistic mechanism of l-SPD on D1R, D2R, and D3R. Our analyses showed that hydrogen bonding of the hydroxyl group on the D ring of l-SPD with side chain of N6.55 which, in combination with hydrophobic stacking between I3.40, F6.44 and W6.48, is the key feature to mediate the agonist effect of l-SPD on D1R, whereas the absence of hydrophobic stacking between I3.40, F6.44, and W6.48 in D2R and D3R excludes receptor activation. Finally, the agonistic and antagonistic mechanisms of l-SPD and an activation model of D1R were proposed on the basis of these findings. The present study could guide future experimental works on these receptors and has the significance to the design of functionally selective drugs targeting dopamine receptors. PMID:22702398

Li, Bian; Li, Wei; Du, Peng; Yu, Kun Qian; Fu, Wei

2012-07-03

280

A Griffiths-like phase in antiferromagnetic R0.5Eu0.5MnO3 (R = Pr, Nd, Sm).  

PubMed

We report a Griffiths-like phase in isovalent doped rare-earth manganites R(0.5)Eu(0.5)MnO(3) (R = Pr, Nd, Sm). Rietveld refinement of the structural data reveals strong orthorhombic and Jahn-Teller distortions. The dc and ac magnetic studies nicely demonstrate aspects of Griffiths phase-like behaviour. The presence of short range ferromagnetically correlated spin clusters is observed above the antiferromagnetic transition temperature. A disorder driven phase inhomogeneity arising from strong structural distortion is the possible origin of this behaviour. PMID:23315393

Karmakar, A; Majumdar, S; Kundu, S; Nath, T K; Giri, S

2013-01-11

281

Association of MC3R gene polymorphisms with body weight in the red fox and comparative gene organization in four canids.  

PubMed

There are five genes encoding melanocortin receptors. Among canids, the genes have mainly been studied in the dog (MC1R, MC2R and MC4R). The MC4R gene has also been analysed in the red fox. In this report, we present a study of chromosome localization, comparative sequence analysis and polymorphism of the MC3R gene in the dog, red fox, arctic fox and Chinese raccoon dog. The gene was localized by FISH to the following chromosome: 24q24-25 in the dog, 14p16 in the red fox, 18q13 in the arctic fox and NPP4p15 in the Chinese raccoon dog. A high identity level of the MC3R gene sequences was observed among the species, ranging from 96.0% (red fox--Chinese raccoon dog) to 99.5% (red fox--arctic fox). Altogether, eight polymorphic sites were found in the red fox, six in the Chinese raccoon dog and two in the dog, while the arctic fox appeared to be monomorphic. In addition, association of several polymorphisms with body weight was analysed in red foxes (the number of genotyped animals ranged from 319 to 379). Two polymorphisms in the red fox, i.e. a silent substitution c.957A>C and c.*185C>T in the 3'-flanking sequence, showed a significant association (P < 0.01) with body weight. PMID:20477806

Skorczyk, A; Flisikowski, K; Szydlowski, M; Cieslak, J; Fries, R; Switonski, M

2011-02-01

282

Selective doping in a surface band and atomic structures of the Ge(111) (\\sqrt{3}\\times \\sqrt{3}){R}3 0^{\\circ}-Au surface  

NASA Astrophysics Data System (ADS)

Atomic and electronic structures of the Ge(111) (\\sqrt{3}\\times \\sqrt{3}){R}3 0^{\\circ}-Au surface with two metallic bands are studied by scanning tunneling microscopy (STM) and angle-resolved photoemission spectroscopy (ARPES). The bias-voltage-dependent periodic structure observed by STM is consistent with the electronic structure calculated for an optimized conjugate honeycomb chained trimer (CHCT) model. Electrons are selectively doped to the electron-like surface metallic band by excess Au atoms, which form triangle structures with the Au trimers of the CHCT model. The discrepancy for the bottom energy of the electron-like band between the ARPES results and those of the calculation is attributed to the doping. The triangle structure is mobile at room temperature, but stable at 80 K. Both Au and Ge atoms deposited at room temperature on the Ge(111) (\\sqrt{3}\\times \\sqrt{3}){R}3 0^{\\circ}-Au surface dope electrons to the electron-like surface metallic band. Moreover, the Au atoms increase the spin-orbit interaction at the surface, and thus make the splitting of the spin-polarized band due to the interaction larger than that before the deposition.

Nakatsuji, Kan; Motomura, Yuya; Niikura, Ryota; Komori, Fumio

2013-01-01

283

THE EVOLUTION OF PLASMA PARAMETERS ON A CORONAL SOURCE SURFACE AT 2.3 R{sub Sun} DURING SOLAR MINIMUM  

SciTech Connect

We analyze data from the Solar and Heliospheric Observatory to produce global maps of coronal outflow velocities and densities in the regions where the solar wind is undergoing acceleration. The maps use UV and white light coronal data obtained from the Ultraviolet Coronagraph Spectrometer and the Large Angle Spectroscopic Coronagraph, respectively, and a Doppler dimming analysis to determine the mean outflow velocities. The outflow velocities are defined on a sphere at 2.3 R{sub Sun} from Sun-center and are organized by Carrington Rotations during the solar minimum period at the start of solar cycle 23. We use the outflow velocity and density maps to show that while the solar minimum corona is relatively stable during its early stages, the shrinkage of the north polar hole in the later stages leads to changes in both the global areal expansion of the coronal hole and the derived internal flux tube expansion factors of the solar wind. The polar hole areal expansion factor and the flux tube expansion factors (between the coronal base and 2.3 R{sub Sun }) start out as super-radial but then they become more nearly radial as the corona progresses away from solar minimum. The results also support the idea that the largest flux tube expansion factors are located near the coronal hole/streamer interface, at least during the deepest part of the solar minimum period.

Strachan, L.; Panasyuk, A. V.; Kohl, J. L. [Harvard-Smithsonian Center for Astrophysics, 60 Garden St., Cambridge, MA 02138 (United States); Lamy, P., E-mail: lstrachan@cfa.harvard.edu [Laboratoire d'Astrophysique de Marseille, UMR6110 CNRS/Universite de Provence, 38 rue Frederic Joliot-Curie, 13388 Marseille Cedex 13 (France)

2012-01-20

284

Diastereomeric complex of (R/S)-piperidine-3-carboxylic acid with (2R,3R)-tartaric acid: Structural, spectroscopic and computational studies  

NASA Astrophysics Data System (ADS)

2:2 Complex of (R) and (S)-piperidine-3-carboxylic acids (P3C) with (2R,3R)-tartaric acid (TA), 1, has been characterized by single-crystal X-ray analysis, FTIR and NMR spectroscopies, and by DFT calculations. The crystals of 1 are monoclinic, space group P21. The crystal structure is formed by two distinct P3CH+·TA- components, A and B, linked by an O-H\\ctdot O hydrogen bond of 2.603(2) Å. The A and B components differ in the absolute configuration of the C(3) atom of P3CH+; (S) in A and (R) in B. The piperidinium-3-carboxylic acid and (2R,3R)-semi-tartrate anion moieties of the components A and B are linked by O-H\\ctdot O hydrogen bonds of 2.517(1) and 2.535(1) Å, respectively. In A and B the piperidinium rings adopt the chair conformation with the carboxyl group in the equatorial position. The structures of the monomers of P3CH+·TA-, 3A and 3B, as well as of a dimer 2, have been optimized by the B3LYP/6-31G(d,p) approach. The chemical shift assignments were based on two-dimensional 1H-1H and 1H-13C experiments.

Bartoszak-Adamska, E.; Dega-Szafran, Z.; Jaskólski, M.; Szafran, M.

2011-07-01

285

Multipurpose Transportation, Aging, and Disposal Canisters for Used Nuclear Fuel - Getting From Here to There and Beyond  

SciTech Connect

The idea of a universal canister system, in which used fuel can be placed at reactor sites, transported and - without ever needing to be re-opened -, disposed of in a geologic repository, is certainly not new. Originally proposed by DOE in the early 1990's as the Multi-Purpose Canister (MPC) system, this common sense idea has always had considerable appeal as a means to reduce used fuel handling and simplify repository surface facility operations. However, difficulties in launching the development of such a system, in the face of large uncertainties in repository design and limited program funding, caused the original MPC project to be abandoned in 1997. Then, after eight years of inactivity in this area, DOE, while experiencing difficulty completing the repository surface facility design and having missed a December 2004 deadline for submittal of a repository license application to the Nuclear Regulatory Commission (NRC), re-proposed the concept. Under this renewed initiative, the MPC systems were renamed as Transportation, Aging, and Disposal or TAD canister systems. DOE's repository design had advanced significantly at this point and industry, having gained considerable experience through the design, licensing, manufacture, and loading of over 800 used fuel dry storage systems, was well positioned to provide DOE with the meaningful technical input that would be necessary to bring the TAD concept to reality. With a firm foundation on which to build, industry actively engaged DOE in an extensive series of interactions to facilitate TAD development. This paper describes the evolution of the TAD concept through the industry/DOE dialogue that occurred over an 18 month period beginning in January 2006. It discusses the technical issues that were addressed and resolved through this collaboration. Successful completion of this dialogue led to the issuance, by DOE, of a final TAD design specification in July, 2007. This specification is being used by DOE as a fundamental input to the Yucca Mountain license application that DOE expects to submit to the NRC no later than June 2008. DOE is now in the process completing a procurement of TAD demonstrations. As part of these demonstrations, DOE expects industry vendors to seek and obtain storage and transportation licenses for the TADs by 2010 and for utilities to deploy them at reactor sites by 2012. (authors)

McCullum, R. [Nuclear Energy Institute, Washington, DC (United States)

2008-07-01

286

Volatile Organic Compounds Identified in Post-Flight Air Analysis of the Multipurpose Logistics Module from International Space Station  

NASA Astrophysics Data System (ADS)

Bioregenerative systems involve storing and processing waste along with atmospheric management. The MPLM, Multipurpose Logistics Module, is a reusable logistics carrier and primary delivery system used to resupply the International Space Station (ISS) and return Station cargo that requires a pressurized environment. The cylindrical module is approximately 6.4 meters long, 4.6 meters in diameter, and weighs almost 4,082kg. The module provides storage and additional workspace for up to two astronauts when docked to the ISS. It can carry up to 9,072 kg of supplies, science experiments, spare parts and other logistical components for ISS. There is concern for a potentially hazardous condition caused by contamination of the atmosphere in the MPLM upon return from orbit. This would be largely due to unforeseen spills or container leakage. This has led to the need for special care in handling the returned module prior to processing the module for its next flight. Prior to opening the MPLM, atmospheric samples are analyzed for trace volatile organic compounds, VOC's. It is noted that our analyses also reflect the atmosphere in the ISS on that day of closure. With the re turn of STS-108, 12th ISS Flight (UF1), the analysis showed 24 PPM of methane. This corresponds to the high levels on space station during a time period when the air filtration system was shut off. Chemical characterization of atmospheres on the ISS and MPLM provide useful information for concerns with plant growth experiments on ISS. Work with closed plant growth chambers show potential for VOC's to accumulate to toxic levels for plants. The ethylene levels for 4 MPLM analyses over the course on one year were measured at, 0.070, 0.017, 0.012 and 0.007 PPM. Phytochemical such as ethylene are detected with natural plant physiological events such as flowering and as a result of plant damage or from decaying food. A build up of VOC's may contribute to phytotoxic effects for the plant growth experiments or health problems for humans. Other identified components from the MPLM are quite similar to those found from off gassing of construction material and laboratory reagents characterized in ground based studies with closed plant growth chambers.

Peterson, B.; Wheeler, R.

287

Hydrothermally controlled growth and magnetic properties of multi-morphology manganese oxide (RMnO3, R=Ca, Sr, Ba) nano- and microcrystals  

NASA Astrophysics Data System (ADS)

This paper presents a general hydrothermal route to multi-morphology manganese oxide (RMnO3, R=Ca, Sr, Ba) nano- and microcrystals and reports the magnetic properties of their nanowires as well. Adjustment of the synthesis conditions, particularly the change of the concentrations of n-hexadecyltrimethylammonium bromide and NaOH, led to the formation of nano- and microcrystals with wire-, belt-, pyramid-, flower-, and arrow-like morphologies. Considering the shape-dependent magnetic properties of nanocrystals, nanowires were selected as representative samples for magnetic measurements. At low temperature, the nanowires exhibited interesting competing ferromagnetic-antiferromagnetic interactions, and the magnetization values increase significantly with increasing the radius of positive ions from Ca2+ to Ba2+.

Zhang, Jinhua; Yu, Dabin; Du, Kai; Wang, Feng; Zhao, Dapeng; Wang, Yong; Chen, Leilei; Kong, Mingguang; Zou, Jiwei

2013-10-01

288

Crystallization and preliminary X-ray study of a (2R,3R)-2,3-butanediol dehydrogenase from Bacillus coagulans 2-6.  

PubMed

(2R,3R)-2,3-Butanediol dehydrogenase (R,R-BDH) from Bacillus coagulans 2-6 is a zinc-dependent medium-chain alcohol dehydrogenase. Recombinant R,R-BDH with a His6 tag at the C-terminus was expressed in Escherichia coli BL21 (DE3) cells and purified by Ni(2+)-chelating affinity and size-exclusion chromatography. Crystals were grown by the hanging-drop vapour-diffusion method at 289?K. The crystallization condition consisted of 8%(v/v) Tacsimate pH 4.6, 18%(w/v) polyethylene glycol 3350. The crystal diffracted to 2.8?Å resolution in the orthorhombic space group P212121, with unit-cell parameters a = 88.35, b = 128.73, c = 131.03?Å. PMID:24100567

Miao, Xiangzhi; Huang, Xianhui; Zhang, Guofang; Zhao, Xiufang; Zhu, Xianming; Dong, Hui

2013-09-28

289

Crystal structure modeling, electrical and thermal characterization of triple molybdates RbCrTi0.5(MoO4)3 (R=Fe, Cr)  

NASA Astrophysics Data System (ADS)

The new triple molybdates of RbRTi0.5(MoO4)3 (R=Fe, Cr) were synthesized by a ceramic route at 580-600 °C. Their crystal structures have been refined by Rietveld analysis of powder X-ray diffraction data on the single crystal data of isostructural CsFeZr0.5(MoO4)3 (trigonal symmetry, space group R-3). The structure refinement converged to satisfactory values of the Rietveld parameters, Rp and Rwp, and goodness of fit. The lattice parameters, bond lengths and bond angles have been calculated from Full Proff program. The maximum value of RbCrTi0.5(MoO4)3 conductivity was 0.57×10-2 S cm-1 at 507 °C.

Dorzhieva, Sesegma G.; Bazarov, Bair G.; Subanakov, Alexey K.; Bazarova, Jibzema G.

2013-03-01

290

Thermal and optical properties of glass and crystalline phases formed in the binary R2O3-Al2O3 (R = La-Lu and Y) system  

NASA Astrophysics Data System (ADS)

Rare-earth aluminate (RAlO3, R = La-Lu and Y) glass and crystalline phases were prepared by containerless levitation in an aerodynamic levitation furnace. In the RAlO3 system, La, Nd and Sm aluminum perovskites solidified as glass and Eu-Lu and Y aluminum perovskites solidified as crystalline phases. The glass forming region decreased with decreasing ionic radius of the rare-earth element. Scanning electron microscopy images and x-ray diffraction results revealed the formation of a single RAlO3 phase from the undercooled melt. The glass transition temperature, Tg, and density increased and the molar volume decreased with decreasing rare-earth element ionic radius. The refractive index at 589 nm exceeds 1.85 in each composition and a transparency of approximately 72% was achieved for the LaAlO3 glass.

Vijaya Kumar, Malahalli; Ishikawa, Takehiko; Basavalingu, B.; Okada, Junpei T.; Watanabe, Yuki

2013-05-01

291

The structures of T6, T3R3 and R6 bovine insulin: combining X-ray diffraction and absorption spectroscopy.  

PubMed

The crystal structures of three conformations, T(6), T(3)R(3) and R(6), of bovine insulin were solved at 1.40, 1.30 and 1.80 Å resolution, respectively. All conformations crystallized in space group R3. In contrast to the T(6) and T(3)R(3) structures, different conformations of the N-terminal B-chain residue PheB1 were observed in the R(6) insulin structure, resulting in an eightfold doubling of the unit-cell volume upon cooling. The zinc coordination in each conformation was studied by X-ray absorption spectroscopy (XAS), including both EXAFS and XANES. Zinc adopts a tetrahedral coordination in all R(3) sites and an octahedral coordination in T(3) sites. The coordination distances were refined from XAS with a standard deviation of <0.01 Å. In contrast to the distances determined from the medium-resolution crystal structures, the XAS results were in good agreement with similar coordination geometries found in small molecules, as well as in other high-resolution insulin structures. As the radiation dose for XRD experiments is two orders of magnitude higher compared with that of XAS experiments, the single crystals were exposed to a higher degree of radiation damage that affected the zinc coordination in the T(3) sites in particular. Furthermore, XANES spectra for the zinc sites in T(6) and R(6) insulin were successfully calculated using finite difference methods and the bond distances and angles were optimized from a quantitative XANES analysis. PMID:22993080

Frankær, Christian Grundahl; Knudsen, Marianne Vad; Norén, Katarina; Nazarenko, Elena; Ståhl, Kenny; Harris, Pernille

2012-09-13

292

Safety Analysis of the Experimental Multi-Purpose High-Temperature Gas-Cooled Reactor. Analysis of Plant Behavior in Normal Operation and Accidents, Based on the Preliminary Conceptual Design.  

National Technical Information Service (NTIS)

Safety features of the experimental multi-purpose high-temperature gas-cooled reactor being developed in JAERI were studied on the basis of its preliminary conceptual design of the reactor plant. Covered are control of the plant in transients, plant behav...

A. Shimazu J. Takaya K. Suzuki M. Ezaki S. Mitake

1976-01-01

293

Electrets - Multipurpose transducers  

Microsoft Academic Search

New applications opening up for electrets in a wide range of fields are reviewed. Typewriters responding to finger touch without displacement of keys, metal dust collecting filters, and high-duty relays with zero leakage current are being worked on. Optical and ultrasonic applications include: low-cost IR detection (thermography, intrusion detection, fire and smoke alarm enunciation, low-light and night vision, IR photography,

M. Lagues

1976-01-01

294

Multi-Purpose Antenna.  

National Technical Information Service (NTIS)

A description is given of a microwave antenna, useful on a spacecraft, which utilizes a single dish reflector and single coaxial horn structure to transmit at two frequencies, and to receive signals at a third frequency that allow tracking. The horn struc...

K. E. Woo

1970-01-01

295

Multipurpose composite flywheel  

SciTech Connect

The twin disk composite flywheel shows that the techniques that were developed at Rocketdyne to successfully design, fabricate, and test high-speed rotating machinery (turbopumps) for rocket engines could be used to develop advanced flywheels. This flywheel not only demonstrates that successful mating of metal flywheel characteristics (high torque and ruggedness) and composite flywheel characteristics (lightweight and high energy density) can be achieved, but the unique design lends itself to easy adaptation to other configurations.

Ginsburg, B.R.

1984-11-01

296

Multipurpose hyperspectral imaging system  

Technology Transfer Automated Retrieval System (TEKTRAN)

A hyperspectral imaging system of high spectral and spatial resolution that incorporates several innovative features has been developed to incorporate a focal plane scanner (U.S. Patent 6,166,373). This feature enables the system to be used for both airborne/spaceborne and laboratory hyperspectral i...

297

Multipurpose spectral imager.  

PubMed

A small spectral imaging system is presented that images static or moving objects simultaneously as a function of wavelength. The main physical principle is outlined and demonstrated. The instrument is capable of resolving both spectral and spatial information from targets throughout the entire visible region. The spectral domain has a bandpass of 12 A. One can achieve the spatial domain by rotating the system's front mirror with a high-resolution stepper motor. The spatial resolution range from millimeters to several meters depends mainly on the front optics used and whether the target is fixed (static) or movable relative to the instrument. Different applications and examples are explored, including outdoor landscapes, industrial fish-related targets, and ground-level objects observed in the more traditional way from an airborne carrier (remote sensing). Through the examples, we found that the instrument correctly classifies whether a shrimp is peeled and whether it can disclose the spectral and spatial microcharacteristics of targets such as a fish nematode (parasite). In the macroregime, we were able to distinguish a marine vessel from the surrounding sea and sky. A study of the directional spectral albedo from clouds, mountains, snow cover, and vegetation has also been included. With the airborne experiment, the imager successfully classified snow cover, leads, and new and rafted ice, as seen from 10.000 ft (3.048 m). PMID:18345245

Sigernes, F; Lorentzen, D A; Heia, K; Svenøe, T

2000-06-20

298

Tagetes: A multipurpose plant  

Microsoft Academic Search

Tagetes species, popularly known as marigold, are grown as ornamental plants and thrive in varied agroclimates. Bioactive extracts of different Tagetes parts exhibit nematocidal, fungicidal and insecticidal activity. Nematocidal activity of roots is attributed to thienyls while the biocidal components of the essential oil from flowers and leaves are terpenoids. Also carotenoid pigments from Tagetes are useful in food coloring.

Padma Vasudevan; Suman Kashyap; Satyawati Sharma

1997-01-01

299

Multipurpose smart hydrogel systems.  

PubMed

This paper represents the review of the last investigations in the field of smart polymeric hydrogels and our contribution to this matter. New hydrogel systems and nanocomposites based on acrylic monomers (acrylamide, acrylonitrile, acrylic acid, N-isopropylacrylamide etc.) with incorporated nanosized colloidal silver, hydroxyapatite and carbon nanotubes with a new set of properties have been obtained and examined. These systems can sharply change their characteristics when minor external physical (electric and magnetic fields, temperature etc.) or chemical (pH, ionic strength) stimuli are applied. Such stimulus-responsive polymeric systems are very promising from the standpoint of different medical applications, especially for the development of intelligent drug delivery systems. On the base of designed hydrogel iontophoretic transdermal therapeutic systems, endoprosthesis for the replacement of bone tissue and hydrogel burns coatings with immobilized mesenchymal cells were obtained and tested. PMID:21782148

Samchenko, Yu; Ulberg, Z; Korotych, O

2011-07-01

300

Synthesis of (4R,6S,7R)-7-hydroxy-4,6-dimethyl-3-nonanone and (3R,5S,6R)- 6-hydroxy-3,5-dimethyl-2-octanone, the pheromone components of the bostrychid beetle, Dinoderus bifoveolatus.  

PubMed

(4R,6S,7R)-7-Hydroxy-4,6-dimethyl-3-nonanone and (3R,5S,6R)-6-hydroxy-3,5-dimethyl-2-octanone, the pheromone components of the bostrychid beetle, Dinoderus bifoveolatus, as well as their (4R,6S,7S)- and (3R,5S,6S)-isomers were synthesized from (2R,4S,5R)- and (2R,4S,5S)-2,4-dimethyl-5-heptanolide, respectively. PMID:12951509

Masuda, Yui; Fujita, Ken; Mori, Kenji

2003-08-01

301

Belford proactive flood solutions: scientific evidence to influence local and national policy by multi-purpose runoff management  

NASA Astrophysics Data System (ADS)

The increased risk from flooding continues to be of concern to governments all around the world and flood protection is becoming more of a challenge. In the UK, climate change projections indicate more extremes within the weather systems. In addition, there is an increased demand for using land in urban areas beside channels. These developments both put pressure on our flood defences and there is a need for new solutions to managing flood risk. There is currently support within the England and Wales Environment Agency for sustainable flood management solutions such as storage ponds, wetlands, beaver dams and willow riparian features (referred to here as Runoff Attenuation Features, or RAFs). However the effectiveness of RAFs are not known at the catchment scale since they have only really been trailed at the plot scale. These types of mitigation measure can offer benefits to water quality and create ecological habitats. The village of Belford, situated in the Belford Burn catchment (6km2), northern England, has suffered from numerous flood events. In addition, the catchment suffers from water quality issues within the channel and high sediment loads are having an impact on the ecology of the nearby estuary. There was a desire by the Local Environment Agency Flood Levy team to deliver an alternative catchment-based solution to the problem. With funding from the Northumbria Regional Flood Defence Committee, the Environment Agency North East Local Levy team and Newcastle University have created a partnership to address the flood problem trailing soft engineered RAF’s at the catchment scale. The partnership project, “Belford proactive flood solutions” is testing novel techniques in reducing flood risk in small sub-catchments for the Environment Agency. The project provides the information needed to understand whether the multi-functional mitigation measures are working at the sub-catchment scale. Data suggest that the mitigation measures present have delayed the overall travel time of the flood peak in the catchment by 33%. The current maximum flood storage capacity of all the features stands at around 15,000 m3. The evidence also suggests that a dam like in-stream mitigation measure can significantly reduce sediment load. Other benefits of some mitigation features include large increase in the population of water voles over the past two years. The scheme also acts as a demonstration site for interested stakeholders where they can learn about this approach to flood risk management and see the multipurpose benefits. As the project has progressed and lessons have been learnt, it has been possible to develop a runoff management toolkit for implementing these mitigation measures in other catchments of similar size. Already, the local Environment Agency has utilised the tools and recently applied similar mitigation measures to other catchments. On-going modelling exercises in the project are using the data to explore the up-scaling of the features to larger catchments.

Wilkinson, M.; Quinn, P. F.; Jonczyk, J.

2010-12-01

302

Environmental, Health and Safety Assessment: ATS 7H Program (Phase 3R) Test Activities at the GE Power Systems Gas Turbine Manufacturing Facility, Greenville, SC  

SciTech Connect

International Technology Corporation (IT) was contracted by General Electric Company (GE) to assist in the preparation of an Environmental, Health and Safety (HI&3) assessment of the implementation of Phase 3R of the Advanced Turbine System (ATS) 7H program at the GE Gas Turbines facility located in Greenville, South Carolina. The assessment was prepared in accordance with GE's contractual agreement with the U.S. Department of Energy (GE/DOE Cooperative Agreement DE-FC21-95MC3 1176) and supports compliance with the requirements of the National Environmental Policy Act of 1970. This report provides a summary of the EH&S review and includes the following: General description of current site operations and EH&S status, Description of proposed ATS 7H-related activities and discussion of the resulting environmental, health, safety and other impacts to the site and surrounding area. Listing of permits and/or licenses required to comply with federal, state and local regulations for proposed 7H-related activities. Assessment of adequacy of current and required permits, licenses, programs and/or plans.

None

1998-11-17

303

Discovery of a New Class of Ionotropic Glutamate Receptor Antagonists by the Rational Design of (2S,3R)-3-(3-Carboxyphenyl)-pyrrolidine-2-carboxylic Acid  

PubMed Central

The kainic acid (KA) receptors belong to the class of glutamate (Glu) receptors in the brain and constitute a promising target for the treatment of neurological and/or psychiatric diseases such as schizophrenia, major depression, and epilepsy. Five KA subtypes have been identified and named GluK1?5. In this article, we present the discovery of (2S,3R)-3-(3-carboxyphenyl)-pyrrolidine-2-carboxylic acid (1) based on a rational design process. Target compound 1 was synthesized by a stereoselective strategy in 10 steps from commercially available starting materials. Binding affinities of 1 at native ionotropic Glu receptors were determined to be in the micromolar range (AMPA, 51 ?M; KA, 22 ?M; NMDA 6 ?M), with the highest affinity for cloned homomeric KA receptor subtypes GluK1,3 (3.0 and 8.1 ?M, respectively). Functional characterization of 1 by two electrode voltage clamp (TEVC) electrophysiology at a nondesensitizing mutant of GluK1 showed full competitive antagonistic behavior with a Kb of 11.4 ?M.

2010-01-01

304

De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes  

PubMed Central

Megalencephaly-capillary malformation (MCAP) and megalencephaly-polymicrogyria-polydactyly-hydrocephalus (MPPH) syndromes are sporadic overgrowth disorders associated with markedly enlarged brain size and other recognizable features1-5. We performed exome sequencing in three families with MCAP or MPPH and confirmed our initial observations in exomes from 7 MCAP and 174 control individuals, as well as in 40 additional megalencephaly subjects using a combination of Sanger sequencing, restriction-enzyme assays, and targeted deep sequencing. We identified de novo germline or postzygotic mutations in three core components of the phosphatidylinositol-3-kinase (PI3K)/AKT pathway. These include two mutations of AKT3, one recurrent mutation of PIK3R2 in 11 unrelated MPPH families, and 15 mostly postzygotic mutations of PIK3CA in 23 MCAP and one MPPH patients. Our data highlight the central role of PI3K/AKT signaling in vascular, limb and brain development, and emphasize the power of massively parallel sequencing in a challenging context of phenotypic and genetic heterogeneity combined with postzygotic mosaicism.

Riviere, Jean-Baptiste; Mirzaa, Ghayda M.; O'Roak, Brian J.; Beddaoui, Margaret; Alcantara, Diana; Conway, Robert L.; St-Onge, Judith; Schwartzentruber, Jeremy A.; Gripp, Karen W.; Nikkel, Sarah M.; Worthylake, Thea; Sullivan, Christopher T.; Ward, Thomas R.; Butler, Hailly E.; Kramer, Nancy A.; Albrecht, Beate; Armour, Christine M.; Armstrong, Linlea; Caluseriu, Oana; Cytrynbaum, Cheryl; Drolet, Beth A.; Innes, A. Micheil; Lauzon, Julie L.; Lin, Angela E.; Mancini, Grazia M. S.; Meschino, Wendy S.; Reggin, James D.; Saggar, Anand K.; Lerman-Sagie, Tally; Uyanik, Gokhan; Weksberg, Rosanna; Zirn, Birgit; Beaulieu, Chandree L.; Majewski, Jacek; Bulman, Dennis E.; O'Driscoll, Mark; Shendure, Jay; Graham, John M.; Boycott, Kym M.; Dobyns, William B.

2012-01-01

305

Anomalous scaling behaviour of cobalt cluster size distributions on graphite, epitaxial graphene and carbon-rich (6?3 × 6?3)R30°  

NASA Astrophysics Data System (ADS)

The influence of the underlying interface on adsorption of cobalt (Co) is investigated by comparing the nucleation and growth of Co at room temperature on three carbon (C) surfaces, i.e. highly oriented pyrolytic graphite (HOPG), epitaxial graphene/SiC(0001) (hereafter abbreviated as EG) and precursor of EG i.e. C-rich (6?3 × 6?3)R30°/SiC(0001) (hereafter abbreviated as 6?3). On all three surfaces, Co adopts Volmer-Weber growth mode via formation of three-dimensional dome-shaped nanoclusters. Co clusters formed on 6?3 surface are smaller but denser than Co/HOPG or Co/EG. Scaling analysis reveals a critical nucleus size, i* = 1 (atom) and the smallest stable cluster (i* + 1) would be a dimer. Co/HOPG and Co/EG have the same order of magnitude for their cluster densities and sizes. Scaling analyses however show that the i* for Co/EG (i* = 3) is larger than Co/HOPG (i* = 0) and in this respect the smallest stable cluster would be tetramer and monomer respectively. This difference is attributed to the influence of an interface situated between graphene and SiC bulk. It appears that EG is more inert than HOPG towards the adsorption of Co and may act as a better substrate to host Co clusters.

Poon, Siew Wai; Wee, Andrew T. S.; Tok, Eng Soon

2012-11-01

306

Density Functional Study of the Ground and Excited State Potential Energy Surfaces of a Light-Driven Rotary Molecular Motor (3R,3'R)-(P,P)-trans-1,1',2,2',3,3',4,4'-Octahydro-3,3'-dimethyl-4,4'-biphenanthrylidene  

NASA Astrophysics Data System (ADS)

Potential energy surfaces of the ground and the first excited singlet states of the (3R,3'R)-(P,P)-trans-1,1',2,2',3,3',4,4'-octahydro-3,3'-dimethyl-4,4'-biphenanthrylidene rotary molecular motor have been investigated along the central C4?C4' double bond twisting mode starting from the (P,P)-trans and from the (P,P)-cis conformations occurring in the photoisomerization cycle of this compound. The potential energy profiles obtained with the help of the state average spin restricted ensemble-referenced Kohn-Sham (SA-REKS) method feature minima on the excited state surface, the positions of which are displaced with respect to the barriers on the ground state surface toward the isomerization products, the (M,M)-cis and the (M,M)-trans conformations, respectively. The origin of these minima is analyzed and explained. The results of the present study suggest that the experimentally observed unidirectionality of photoinduced rotation in the above compound can be corroborated by the obtained profiles of the ground and excited state potential energy surfaces.

Kazaryan, Andranik; Filatov, Michael

2009-07-01

307

Transcriptional regulation of the genes encoding cytochromes P450BM-1 and P450BM-3 in Bacillus megaterium by the binding of Bm3R1 repressor to Barbie box elements and operator sites.  

PubMed

We previously reported (Liang, Q., He, J.-S., and Fulco, A.J. (1995) J. Biol. Chem. 270, 4438-4450) that Bm3R1, a repressor regulating the expression of P450BM-3 in Bacillus megaterium, could bind to Barbie box sequences in the 5'-flanking regions of barbiturate-inducible genes. We've now shown that pentobarbital does not inhibit in vitro binding of Bm3R1 to the P450BM-3 and P450BM-1 Barbie boxes (BB3 and BB1), although the palindromic operator sequence (OIII) of P450BM-3 did have a strong competitive effect on such binding. G39E-Bm3R1, a mutant of Bm3R1, did not bind to either Barbie box. In the presence of Bm3R1, portions of the regulatory regions of P450BM-3 and P450BM-1 were protected from DNase I digestion. These included 11 of the 15 base pairs of BB3 plus 7 base pairs 3' to BB3, BB1 plus 16 base pairs 3' to BB1, and, in the 5'-flanking region of P450BM-1, segments covering most of two palindromic sequences (OII and OIII) of 24 and 52 base pairs. These DNase I-protected regions (including OIII) showed considerable sequence identity, especially in a conserved poly(A) motif. Barbiturates did not inhibit binding of Bm3R1 to OI. OII in vitro while G39E-Bm3R1 did not bind. The regulatory effects of Bm3R1 on P450BM-1 and P450BM-3 were also evaluated in vivo using heterologous chloramphenicol acetyltransferase constructs and Western blotting. In the G39E mutant strain, both P450BM-1 and P450BM-3 were constitutively expressed, and the regulatory proteins Bm1P1 and Bm3P1, although still pentobarbital-inducible, had significantly higher basal levels of synthesis. In toto, our results show that Bm3R1 represses both P450BM-1 and P450BM-3 expression and that it may effect this by coordinate binding to operator and Barbie box sequences to produce looping of the P450BM-1 and P450BM-3 regulatory regions through protein-protein interaction. PMID:7629191

Liang, Q; Fulco, A J

1995-08-01

308

In vivo roles of Bm3R1 repressor in the barbiturate-mediated induction of the cytochrome P450 genes (P450(BM-3) and P450(BM-)1) of Bacillus megaterium.  

PubMed

We previously showed [Q. Liang, A.J. Fulco, J. Biol. Chem., 270 (1995) 18606-18614) that the binding of Bm3R1 repressor to Barbie box elements and operator sites in the 5'-flanking regions of the P450BM-3 and P450BM-1 (CYP102 and CYP106) genes in Bacillus megaterium was a critical factor in their regulation at the level of transcription. We now describe experiments that delineate specific roles for Bm3R1 in the barbiturate-mediated induction of these genes. We directly demonstrate the interaction of Bm3R1 with Barbie box and operator sequences and show that high in vivo levels of Bm3R1 prevent putative positive factors from binding to Barbie box elements, strongly inhibit the expression of the P450 genes, prolong the lag phase of growth in Bacillus megaterium cultures and increase the sensitivity of the cells to the growth-inhibitory effects of barbiturates. Finally, our data suggest that there may be two forms of Bm3R1, either of which can interact with OIII, the bicistronic operator sequence. PMID:9565684

Liang, Q; Chen, L; Fulco, A J

1998-04-10

309

A scanning tunneling microscopy study of distyrylbenzene on Ag/Ge(111)-(sqr rt of 3 x sqr rt of 3)R30 degrees.  

PubMed

The adsorption and self-organized monolayers of trans,trans-distyrylbenzene (tt-DSB) and cis,cis-distyrylbenzene (cc-DSB) on Ag/Ge(111)-(sqr rt of 3 x sqr rt of 3)R30 degrees (Ag/Ge(111)-sqr rt of 3) were studied by low-temperature scanning tunneling microscopy (STM) in ultrahigh vacuum. tt-DSB and cc-DSB overlayers were prepared by vapor deposition at a substrate temperature of 200 K and imaged after the samples were cooled to 100 K. High-resolution images allow identification of the internal structure of individual tt-DSB molecules with three phenyl rings and their molecular arrangements on the Ag/Ge(111)-sqr rt of 3 surface. It is found that the intermolecular distance between two terminal phenyl rings in tt-DSB is about twice the lattice constant of Ag/Ge(111)-sqr rt of 3. Such a lattice match makes Ag/Ge(111)-sqr rt of 3 an ideal substrate for tt-DSB self-organization and the formation of a (3 x 1) overlayer unit cell. The structural model and the molecule registry corresponding to STM images for the adlayers of tt-DSB on Ag/Ge(111)-sqr rt of 3 are proposed and discussed. For cc-DSB adsorption on Ag/Ge(111)-sqr rt of 3, uniform molecular overlayers with two discernible molecular images corresponding to two major types of cc-DSB conformers were observed. The coexistence of multiple conformers and the mismatch of molecular dimension of cc-DSB with the substrate unit cell length limit the growth of large cc-DSB domains. PMID:17973407

Wu, H C; Tsai, C-S; Chou, L-W; Lee, Y-R; Jiang, J C; Su, C; Lin, J-C

2007-10-31

310

Developmental regulation of GABAergic signalling in the hippocampus of neuroligin 3 R451C knock-in mice: an animal model of Autism  

PubMed Central

Autism Spectrum Disorders (ASDs) comprise an heterogeneous group of neuro-developmental abnormalities, mainly of genetic origin, characterized by impaired social interactions, communications deficits, and stereotyped behaviors. In a small percentage of cases, ASDs have been found to be associated with single mutations in genes involved in synaptic function. One of these involves the postsynaptic cell adhesion molecule neuroligin (NL) 3. NLs interact with presynaptic neurexins (Nrxs) to ensure a correct cross talk between post and presynaptic specializations. Here, transgenic mice carrying the human R451C mutation of Nlgn3, were used to study GABAergic signaling in the hippocampus early in postnatal life. Whole cell recordings from CA3 pyramidal neurons in slices from NL3R451C knock-in mice revealed an enhanced frequency of Giant Depolarizing Potentials (GDPs), as compared to controls. This effect was probably dependent on an increased GABAergic drive to principal cells as demonstrated by the enhanced frequency of miniature GABAA-mediated (GPSCs), but not AMPA-mediated postsynaptic currents (EPSCs). Changes in frequency of mGPSCs were associated with an acceleration of their decay kinetics, in the absence of any change in unitary synaptic conductance or in the number of GABAA receptor channels, as assessed by peak scaled non-stationary fluctuation analysis. The enhanced GABAergic but not glutamatergic transmission early in postnatal life may change the excitatory/inhibitory balance known to play a key role in the construction and refinement of neuronal circuits during postnatal development. This may lead to behavioral deficits reminiscent of those observed in ASDs patients.

Pizzarelli, Rocco; Cherubini, Enrico

2013-01-01

311

Charge disproportionation in RNiO3 (R= Tm, Yb) perovskites observed in situ by neutron diffraction and 57Fe probe Mössbauer spectroscopy  

NASA Astrophysics Data System (ADS)

An in-situ investigation from high-resolution neutron powder diffraction data on the structural evolution of TmNiO3 and YbNiO3 perovskites across the metal-insulator transition, with TMI = 596 K and 598 K, respectively, allowed the charge disproportionation effect that these perovskites experience upon electronic localization below TMI to be followed. In the insulating (semiconducting) regime, the perovskites are monoclinic, space group P21/n, containing two inequivalent Ni1(3+?)+ and Ni2(3??)+ cations; above TMI, the samples become orthorhombic, space group Pbnm, with a single site for Ni3+. The 57Fe Mössbauer spectra of iron-doped (at 1.5%) RNiO3 (R = Tm, Yb) samples recorded below TMI exhibit for Fe1 and Fe2 (replacing Ni1 and Ni2 sites) hyperfine parameters corresponding to large (Ni1O6) and small (Ni2O6) octahedra. The remarkable difference between the quadrupole splittings (?1 ? 0.3 mm/s and ?2 ? 0.07 mm/s) of Fe1 and Fe2 sites in RNi0.985Fe0.015O3 is analyzed. We calculate the lattice contribution to the electric field gradient (EFG) at 57Fe ions, and estimate, by using the experimental ?1 and ?2 values, the contributions of the 3d, 3p, and 2p electrons (overlap distortion and covalence effects). Above TMI, a unique state for iron atoms is observed, upon metallization of the sample.

Alonso, J. A.; Martínez-Lope, M. J.; Presniakov, I. A.; Sobolev, A. V.; Rusakov, V. S.; Gapochka, A. M.; Demazeau, G.; Fernández-Díaz, M. T.

2013-05-01

312

Bis(arene) actinide sandwich complexes, ({eta}{sup 6}-C{sub 6}H{sub 3}R{sub 3}){sub 2}An: Linear or bent?  

SciTech Connect

The syntheses of the sandwich complexes ferrocene, ({eta}{sup 5}-C{sub 5}H{sub 5}){sub 2}-Fe, in 1951 and uranocene, ({eta}{sup 8}-C{sub 8}H{sub 8}){sub 2}U, in 1968 ushered in the modern eras of organotransition metal and organoactinide chemistry, respectively. Ferrocene and uranocene are examples of linear sandwich complexes, that is, those in which the (ring centroid)-M-(ring centroid) angle (denoted {theta}) is 180{degree}. In the case of ({eta}{sup 5}-C{sub 5}H{sub 5}){sub 2}M chemistry, a number of bent ({theta} < 180{degree}) complexes are known when M is a main-group or rare-earth element. The explanation for the bent structures of these complexes has been the subject of some debate concerning the relative importance of covalent, electrostatic, and steric interactions. The authors report optimized geometries of Bz{sub 2}An (An = Th-Am) and ({eta}{sup 6}-C{sub 6}H{sub 3}R{sub 3}){sub 2}An (An = Th, U, Pu; R = Me, {sup t}Bu) obtained by using local density approximation (LDA) and Perdew-Wang (PW91) gradient-corrected relativistic density functional theory (DFT) methods. These DFT methods are found to be able to reproduce the experimental geometries and vibrational frequencies of organoactinide complexes with satisfactory accuracy. The (TTB){sub 2}An calculations that are reported here are, to date, the largest full geometry optimizations to be carried out on an actinide system.

Li, J.; Bursten, B.E.

1999-11-03

313

A novel photoelectrochemical sensor based on PPIX-functionalized WO3-rGO nanohybrid-decorated ITO electrode for detecting cysteine.  

PubMed

A universal photoelectrochemical (PEC) sensing platform was fabricated based on the composition of protoporphyrin IX (PPIX), tungsten trioxide (WO3) and reduced graphene oxide (rGO) on indium tin oxide (ITO) electrode for detecting cysteine in aqueous solution. The rGO layer was not only providing bridges for the ITO electrode to anchor tightly with the WO3 nanostructures, but behaved as an electron transfer medium to enhance the electron transport from the conduction band (CB) of WO3. Furthermore, the strong absorption coefficient of porphyrin adsorbed onto WO3 nanoplates by bidentate binding could significantly improve the photocurrent density and slow charge recombination kinetics through the ultrafast electron injection. The SEM, XRD, and DRS were employed to characterize the prepared nanomaterials and modified-ITO electrodes. The results showed that the PPIX-WO3-rGO/ITO electrode could render the capability of absorbing a broad UV-vis light and displayed excellent photocurrent response in 0.1M pH 7.0 PBS with excitation wavelength at 380 nm, which could be notably improved upon addition of cysteine at 0.3 V. Based on the enhanced photocurrent signal, a novel method for PEC detection of cysteine was developed with a linear range of 0.1 to 100 ?M in 0.1M PBS (pH 7.0). The detection limit was 25 nM (3?). And higher stability and selectivity were obtained. The novel strategy could provide a fast and sensitive method for cysteine analysis. PMID:23391706

Sun, Bing; Zhang, Kun; Chen, Lijian; Guo, Lintong; Ai, Shiyun

2013-01-16

314

Vertebrate Vitellogenin Gene Duplication in Relation to the "3R Hypothesis": Correlation to the Pelagic Egg and the Oceanic Radiation of Teleosts  

PubMed Central

The spiny ray-finned teleost fishes (Acanthomorpha) are the most successful group of vertebrates in terms of species diversity. Their meteoric radiation and speciation in the oceans during the late Cretaceous and Eocene epoch is unprecedented in vertebrate history, occurring in one third of the time for similar diversity to appear in the birds and mammals. The success of marine teleosts is even more remarkable considering their long freshwater ancestry, since it implies solving major physiological challenges when freely broadcasting their eggs in the hyper-osmotic conditions of seawater. Most extant marine teleosts spawn highly hydrated pelagic eggs, due to differential proteolysis of vitellogenin (Vtg)-derived yolk proteins. The maturational degradation of Vtg involves depolymerization of mainly the lipovitellin heavy chain (LvH) of one form of Vtg to generate a large pool of free amino acids (FAA 150–200 mM). This organic osmolyte pool drives hydration of the ooctye while still protected within the maternal ovary. In the present contribution, we have used Bayesian analysis to examine the evolution of vertebrate Vtg genes in relation to the “3R hypothesis” of whole genome duplication (WGD) and the functional end points of LvH degradation during oocyte maturation. We find that teleost Vtgs have experienced a post-R3 lineage-specific gene duplication to form paralogous clusters that correlate to the pelagic and benthic character of the eggs. Neo-functionalization allowed one paralogue to be proteolyzed to FAA driving hydration of the maturing oocytes, which pre-adapts them to the marine environment and causes them to float. The timing of these events matches the appearance of the Acanthomorpha in the fossil record. We discuss the significance of these adaptations in relation to ancestral physiological features, and propose that the neo-functionalization of duplicated Vtg genes was a key event in the evolution and success of the teleosts in the oceanic environment.

Finn, Roderick Nigel; Kristoffersen, B?rge A.

2007-01-01

315

A comparison of the antimicrobial spectra and kill rates of three contact lens care solutions: QuickCARE Starting Solution, ReNu Multi-Purpose Solution, and Opti-Free rinsing, disinfecting, and storage solution  

Microsoft Academic Search

The speed of cleaning and disinfection of contact lenses is a significant factor in patient compliance with lens care regimens. A solution that offers the advantage of speed, CIBA Vision QuickCARE Starting Solution, was compared with Alcon Opti-Free Rinsing, Disinfecting, and Storage Solution and Bausch & Lomb ReNu Multi-Purpose Solution for antimicrobial efficacy by the use of time course microbial

Libero Ajello; Marc Ajello

1995-01-01

316

Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: The Cache County Dementia Progression Study.  

PubMed

BACKGROUND: Single-nucleotide polymorphisms (SNPs) located in the gene encoding the regulatory subunit of the protein phosphatase 2B (PPP3R1, rs1868402) and the microtubule-associated protein tau (MAPT, rs3785883) gene were recently associated with higher cerebrospinal fluid (CSF) tau levels in samples from the Knight Alzheimer's Disease Research Center at Washington University (WU) and Alzheimer's Disease Neuroimaging Initiative (ADNI). In these same samples, these SNPs were also associated with faster functional decline, or progression of Alzheimer's disease (AD) as measured by the Clinical Dementia Rating sum of boxes scores (CDR-sb). We attempted to validate the latter association in an independent, population-based sample of incident AD cases from the Cache County Dementia Progression Study (DPS). METHODS: All 92 AD cases from the DPS with a global CDR-sb ?1 (mild) at initial clinical assessment who were later assessed on CDR-sb data on at least two other time points were genotyped at the two SNPs of interest (rs1868402 and rs3785883). We used linear mixed models to estimate associations between these SNPs and CDR-sb trajectory. All analyses were performed using Proc Mixed in SAS. RESULTS: Although we observed no association between rs3785883 or rs1868402 alone and change in CDR-sb (P > .10), there was a significant association between a combined genotype model and change in CDR-sb: carriers of the high-risk genotypes at both loci progressed >2.9 times faster than noncarriers (P = .015). When data from DPS were combined with previously published data from WU and ADNI, change in CDR-sb was 30% faster for each copy of the high-risk allele at rs3785883 (P = .0082) and carriers of both high-risk genotypes at both loci progressed 6 times faster (P < .0001) than all others combined. CONCLUSIONS: We replicate a previous report by Cruchaga et al that specific variations in rs3785883 and rs1868402 are associated with accelerated progression of AD. Further characterization of this association will provide a better understanding of how genetic factors influence the rate of progression of AD and could provide novel insights into preventative and therapeutic strategies. PMID:23727081

Peterson, David; Munger, Caitlin; Crowley, Jared; Corcoran, Chris; Cruchaga, Carlos; Goate, Alison M; Norton, Maria C; Green, Robert C; Munger, Ronald G; Breitner, John C S; Welsh-Bohmer, Kathleen A; Lyketsos, Constantine; Tschanz, Joann; Kauwe, John S K

2013-05-30

317

Synthesis of New 6-{[?-(Dialkylamino(heterocyclyl)alkyl]thio}-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones and Evaluation of their Anticancer and Antimicrobial Activities  

PubMed Central

Several novel 6-thio-3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-based compounds containing an ?-(dialkylamino(heterocyclyl)]alkyl fragment were synthesized to examine their anticancer activity. Some of the 6-{[?-(hetero-cyclyl)alkyl]thio}-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones (3.1–3.10) were obtained by the nucleophilic substitution of 6-[?-halogenalkyl]thio-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones (2.1–2.8) with azaheterocycles. Alternatively, compounds 3.1–3.22 were synthesized by alkylation of 3-R-6-thio-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones potassium salts (1.1–1.4) with (2-chloroethyl)-N,N-dialkylamine hydrochlorides or 1-(2-chloroethyl)heterocycle hydrochlorides. The structures of compounds were elucidated by 1H, 13C NMR, LC–MS and EI-MS analysis. Then anticancer and antibacterial, bioluminescence inhibition of Photobacterium leiognathi Sh1 activities of the substances were tested in vitro. It was found that compound 3.18 possessed a wide range of anticancer activity against 27 cell lines of cancer: non-small cell lung, colon, CNS, ovarian, renal, prostate, breast, melanoma and leukemia (log GI50 < ?5.65). The “structure-activity” relationship was discussed. COMPARE analysis for synthesized anticancer active compounds was performed.

Berest, Galina G.; Voskoboynik, Olexiy Y.; Kovalenko, Sergiy I.; Nosulenko, Inna S.; Antypenko, Lyudmyla M.; Antypenko, Olexii M.; Shvets, Volodymyr M.; Katsev, Andriy M.

2012-01-01

318

Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r.  

PubMed

Association of the PDHK2 and GST-L2 (glutathione-S-transferase fused to the inner lipoyl domain (L2) of dihydrolipoyl acetyltransferase (E2)) dimers was enhanced by K+ with higher affinity K+ binding than occurs at the PDHK2 active site. Supporting a distinct K+ binding site, the NH4+ ion did not effectively replace K+ in aiding GST-L2 binding. With 50 mM K+, Pi enhanced interference by ADP, ATP, or pyruvate of PDHK2 binding to GST-L2. The inclusion of Pi with ADP or ATP plus pyruvate greatly hindered PDHK2 binding to GST-L2 and promoted PDHK2 forming a tetramer. Reciprocally, GST-L2 interference with ATP/ADP binding also required elevated K+ and was increased by Pi. Potent inhibition by Nov3r of E2-activated PDHK2 activity (IC50 of approximately 7.8 nM) required elevated K+ and Pi. Nov3r only modestly inhibited the low activity of PDHK2 without E2. By binding at the lipoyl group binding site, Nov3r prevented PDHK2 binding to E2 and GST-L2. Nov3r interfered with high-affinity binding of ADP and pyruvate via a Pi-dependent mechanism. Thus, GST-L2 binding to PDHK2 is supported by K+ binding at a site distinct from the active site. Pi makes major contributions to ligands interfering with PDHK2 binding to GST-L2, the conversion of PDHK2 dimer to a tetramer, and Nov3r (an acetyl-lipoate analog) interfering with binding of ADP and pyruvate. Pi is suggested to facilitate transmission within PDHK2 of the stimulatory signal of acetylation from the distal lipoyl-group binding site to the active site. PMID:18220415

Hiromasa, Yasuaki; Yan, Xiaohua; Roche, Thomas E

2008-01-26

319

Strukturelle, optische und spektroskopische Untersuchungen von Seltenen-Erd-Perowskiten RGaO(sub 3) (R=La, Pr, Nd) und NdBa(sub 2)Cu(sub 3)O(sub 7-(delta)). (Structural, optical and spectroscopical investigations into rare-earths perowskites RGaO(sub 3) (R=La, Pr, Nd) and NdBa-2Cu(sub 3)O(sub 7-(delta))).  

National Technical Information Service (NTIS)

In this work I was engaged in rare-earth perovskites. Primarily I investigated the structure of the rare-earth gallates RGaO(sub 3) (R=La, Pr, Nd) as a function of the temperature by means of neutron diffraction and x-ray diffraction. As the high-T(sub c)...

W. Marti

1995-01-01

320

Effects of species and season on chemical composition and ruminal crude protein and organic matter degradability of some multi-purpose tree species by West African dwarf rams.  

PubMed

Seasonal chemical composition and ruminal organic matter (OM) and crude protein (CP) degradabilities were determined in four tropical multi-purpose tree species (MPTS) namely; Pterocarpus santalinoides, Grewia pubescens, Enterolobium cyclocarpum and Leucaena leucocephala. Three West African dwarf (WAD) rams fitted with permanent rumen cannula were used for the degradability trials. Foliage samples were collected four times to represent seasonal variations as follows: January--mid dry; April--late dry; July--mid rainy and October--late rainy seasons. Leaf samples were randomly collected from the trees for estimation of dry matter (DM) and chemical composition. Ruminal in sacco OM and CP degradabilities were estimated from residues in nylon bags. All samples had high CP (161-259 g/kg DM) and moderate fibre concentrations [neutral detergent fibre (without residual ash], 300-501 g/kg DM; acid detergent fibre (without residual ash), 225-409 g/kg DM and acid detergent lignin, 87-179 g/kg DM across seasons. Interaction effects of species and season on chemical composition were highly significant (p = 0.001) except for trypsin inhibitor (p = 0.614). The MPTS recorded more than 60% OM and CP degradability at 24 h, which implied that they were all highly degradable in the rumen. Their incorporation into ruminant feeding systems as dry season forage supplements is therefore recommended. PMID:21535229

Arigbede, O M; Anele, U Y; Südekum, K-H; Hummel, J; Oni, A O; Olanite, J A; Isah, A O

2011-05-02

321

NEW CELL SURFACE gp70 RELATED TO FRIEND MINK CELL FOCUS-INDUCING VIRUS IS EXPRESSED ON FRIEND VIRUS-INDUCED ERYTHROLEUKEMIC SPLEEN CELLS AFTER ELIMINATION OF ECOTROPIC FRIEND VIRUS gp70 IN Rfv-3 r\\/s MICE  

Microsoft Academic Search

Multiple host genes have been shown to influence the course of erythroleukemia induced by Friend virus (FV) 1 (1). Two H-2-associated genes and a non-H-2-1inked gene are required for recovery from FV leukemia (2, 3). The non-H-2-1inked gene, Rfv-3, appears to influence the production of anti-FV antibody independent of the H-2 genotype (3). Although mice of the Rfv-3 r\\/~ genotype

WILLIAM J. BRITT; JAMES K. COLLINS; BRUCE CHESEBRO

322

Does the ACE I\\/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?  

Microsoft Academic Search

We investigated the association of the angiotensin converting enzyme gene (ACE) insertion\\/deletion (I\\/D) polymorphism, alone or in combination with the ?-actinin-3 gene (ACTN3) R577X polymorphism, with jumping (vertical squat and counter-movement jump tests) and sprint ability (30 m dash) in non-athletic,\\u000a healthy young adults [N = 281 (214 male), mean (SD) age 21 (2) years]. We did not observe any effect of the ACE

Gabriel Rodriguez-RomoJonatan; Jonatan R. Ruiz; Catalina Santiago; Carmen Fiuza-Luces; Marta González-Freire; Félix Gómez-Gallego; María Morán; Alejandro Lucia

2010-01-01

323

A Monte Carlo simulation for the stripping of the Square_Root3 x[Square_Root]3 R30[deg] alkanethiol lattice from Au(111) terraces and steps  

Microsoft Academic Search

Monte Carlo simulations of a model for the stripping of Square_Root3 xSquare_Root3 R30deg alkanethiol lattices from terraces and steps of a (111) metal face in aqueous solutions are presented. In the model the stripping probability of an adsorbed alkanethiolate molecule depends on the applied potential, on intermolecular forces that stabilize the alkanethiol layer, and on the presence of substrate defects.

H. Martin; C. Vericat; G. Andreasen; M. E. Vela; R. C. Salvarezza

2002-01-01

324

Experimental thermochemistry of SiCl3R (R = Cl, H, CH3, C2H5, C2H3, CH2Cl, SiCl3), SiCl3+, and SiCl3*.  

PubMed

The 0 K onsets (E(0)) of a series of trichlorosilane derivatives SiCl(3)R --> SiCl(3)(+)+ R(*) (R = Cl, H, CH(3), C(2)H(5), C(2)H(3), CH(2)Cl, SiCl(3)) are measured by threshold photoelectron-photoion coincidence spectroscopy. The well-known heat of formation of SiCl(4) is used as an anchor to determine the heat of formation of SiCl(3)(+), which is, in turn, used as an anchor to determine the heats of formation of the other alkyltrichlorosilanes investigated. A series of isodesmic reactions at the G3 and CBS-QB3 levels are shown to accurately reproduce the experimental heats of formation, and this scheme is used to calculate the heat of formation of Si(2)Cl(6), from which the measured E(0) determines the SiCl(3)(*) heat of formation. The measured values then determine the IE of SiCl(3)(*) along with the Si-R bond dissociation enthalpies of the six neutral species investigated. The experimental heats of formation are also used in a series of isodesmic reaction calculations to determine the heats of formation of SiH(3)R (R = H, CH(3), C(2)H(5), C(2)H(3), CH(2)Cl, SiCl(3)). PMID:19653672

Shuman, Nicholas S; Spencer, Austin P; Baer, Tomas

2009-08-04

325

Critical behavior of the paramagnetic to antiferromagnetic transition in orthorhombic and hexagonal phases of RMnO3 (R=Sm, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y)  

NASA Astrophysics Data System (ADS)

The critical behavior of the paramagnetic to antiferromagnetic transition in RMnO3 (R = Sm, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y) has been studied with an ac photopyroelectric calorimeter, which gives simultaneously the thermal diffusivity and specific heat as a function of temperature with high resolution around the Néel temperature. RMnO3 (R = Sm, Tb, Dy) has an orthorhombic perovskite structure, whereas the other manganites are hexagonal, thus revealing a strong thermal anisotropy. SmMnO3 with type-A antiferromagnetic ordering exhibits a 3D-XY critical behavior, which could be attributed to the peculiar site anisotropy of Sm3+ and the exchange interaction between Mn3+ and Sm3+ ions. The sinusoidal spin ordering in TbMnO3 and DyMnO3 can be phenomenologically described by the 3D-Heisenberg model. Finally, the hexagonal manganites RMnO3 (R = Ho, Er, Tm, Yb, Lu, Y) are close to the 3D-Heisenberg universality class, ruling out the chiral models predicted by the renormalization group theory.

Oleaga, A.; Salazar, A.; Prabhakaran, D.; Cheng, J.-G.; Zhou, J.-S.

2012-05-01

326

Micropropagation of Pithecellobium dulce (Roxb.) Benth-a multipurpose leguminous tree and assessment of genetic fidelity of micropropagated plants using molecular markers.  

PubMed

An efficient and reproducible protocol has been developed for in vitro propagation of Pithecellobium dulce (Roxb.) Benth (a multipurpose leguminous tree) from field grown nodal segments (axillary bud). Shoot bud induction occurred from nodal explants of 15-years-old tree on Murashige and Skoog (MS) basal medium supplemented with 4.4 ?M 6-benzyladenine (BA) and multiplication was achieved on MS medium supplemented with 4.4 ?M BA + 0.73 ?M phenylacetic acid (PAA) i.e. up to 7 shoot buds in the period of 5-6 weeks. Addition of adenine sulphate (AdS) to this medium further enhanced the number of shoot buds up to 10. Proliferating shoot cultures were established by repeatedly subculturing primary culture on fresh medium (MS + 4.4 ?M BA + 0.73 ?M PAA) after every 25 days. In vitro rooting was achieved on MS medium supplemented with 2.46 ?M Indole-3-butyric acid (IBA) + 41.63 ?M activated charcoal (AC). The micropropagated shoots with well developed roots were acclimatized in green house in pots containing sand, soil and manure (1:1:1). Genetic stability of micropropagated clones was evaluated using Random amplified polymorphic DNA (RAPD) and Inter simple sequence repeat (ISSR) markers. The amplification products were monomorphic in micropropagated plants and similar to those of mother plant. No polymorphism was detected revealing the genetic uniformity of micropropagated plants. This is the first report of an efficient protocol for regeneration of P. dulce through organogenesis, which can be used for further genetic transformation and pharmaceutical purposes. PMID:23573054

Goyal, Pooja; Kachhwaha, Sumita; Kothari, S L

2012-04-03

327

Identification and susceptibility to multipurpose disinfectant solutions of bacteria isolated from contact lens storage cases of patients with corneal infiltrative events.  

PubMed

Corneal infiltrative events (CIEs) are being reported with increasing frequency in lens wearers and may be related to specific multipurpose disinfecting solution (MPDS), contact lens type or bacterial bio-burden. Here, the efficacy of MPDS's against bacteria from contact lens storage cases (CLSC) of patients with CIEs was investigated. Eighteen CLSC from patients with CIEs were cultured. All reported using the same MPDS based on PQ-1+Aldox+nonanoyl-EDTA prior to experiencing CIEs. Bacteria were identified and tested for sensitivity to MPDS-1 and three other MPSDs. 16/18 CLSC (89%) contained bacterial counts of ?10(4)-10(8)/mL. Achromobacter spp. was most frequently identified and was found in 11/18 cases (61%). This was followed by 4/18 (22%) Stenotrophomonas maltophilia, 3/18 (17%) Serratia marcescens, 3/18 (17%) Delftia spp., 2/18 (11%) Elizabethkingia spp., 2/18 (11%) Chryseobacterium indologenes and 1/18 Sphingobacterium spiritivorum. Acanthamoeba was not isolated. All of the Achromobacter strains were resistant to MPDS-1 with <1log10 kill up to 14 days exposure and the solution also showed reduced efficacy against the other isolates at the manufacturer's recommended disinfection time of 6h. Two strains of S. maltophilia and Delftia spp. grew in the solution over 14 days. Factors responsible for causing adverse events such as CIEs in contact lens wearers remain unclear. However, the presence of significant bio-burden in the contact lens storage case and lens may initiate an immunological response resulting in CIEs either directly or through the release of endotoxins (e.g. lipopolysaccharides) from the bacterial outer cell membrane. PMID:23466175

Kilvington, Simon; Shovlin, Joseph; Nikolic, Marina

2013-03-01

328

Insulin-like Growth Factor-binding Protein-3 (IGFBP-3) Blocks the Effects of Asthma by Negatively Regulating NF-?B Signaling through IGFBP-3R-mediated Activation of Caspases*?  

PubMed Central

Insulin-like growth factor-binding protein-3 (IGFBP-3) is a multifunctional protein known for modulating mitogenic and metabolic actions of IGFs as well as exerting a variety of biological actions not involving IGFs. Here, we show that IGFBP-3 blocks specific physiological consequences of asthma in an IGF-independent manner in vitro and in vivo. IGFBP-3 treatment effectively reduced all physiological manifestations of asthma examined in vivo (airway hyper-responsiveness, cellular and pathological changes in bronchoalveolar lavage fluid and lung tissue, and expression of numerous proinflammatory molecules). These unique IGFBP-3 effects were further confirmed in IGFBP-3-transgenic mice, thus strengthening the notion of IGFBP-3 actions within the respiratory system. Using human epithelial cells, we demonstrated the following: 1) IGFBP-3 blocks TNF-?-induced expression of proinflammatory molecules; 2) IGFBP-3 attenuates the TNF-?-induced migratory response of eosinophils; and 3) IGFBP-3 negatively regulates TNF-?-induced expression of the key NF-?B regulatory molecules I?B? and p65-NF-?B at the post-translational level. We identified that IGFBP-3 degrades I?B? and p65-NF-?B proteins through IGFBP-3 receptor (IGFBP-3R)-mediated activation of caspases thereby inhibiting TNF-?-induced activation of NF-?B signaling cascades. This unique IGFBP-3/IGFBP-3R action was further confirmed by demonstrating complete inhibition of IGFBP-3 action in the presence of caspase inhibitors as well as IGFBP-3R siRNAs. Non-IGF-binding IGFBP-3 mutants further proved the IGF-independent action of IGFBP-3. Our findings indicate that IGFBP-3 inhibits airway inflammation and hyper-responsiveness via an IGF-independent mechanism that involves activation of IGFBP-3R signaling and cross-talk with NF-?B signaling. The IGFBP-3/IGFBP-3R system therefore plays a pivotal role in the pathogenesis of asthma and can serve as a newly identified potential therapeutic target for this debilitating disease.

Lee, Yong-Chul; Jogie-Brahim, Sherryline; Lee, Dae-Yeol; Han, Jinfeng; Harada, Aki; Murphy, Liam J.; Oh, Youngman

2011-01-01

329

Analysis of V(lambda)-J(lambda) expression in plasma cells from primary (AL) amyloidosis and normal bone marrow identifies 3r (lambdaIII) as a new amyloid-associated germline gene segment.  

PubMed

Primary (AL) amyloidosis is a plasma cell dyscrasia characterized by extracellular deposition of monoclonal light-chain variable region (V) fragments in the form of amyloid fibrils. Light-chain amyloid is rare, and it is not fully understood why it occurs in only a fraction of patients with a circulating monoclonal component and why it typically associates with lambda isotype and lambdaVI family light-chain proteins. To provide insights into these issues, we obtained complete nucleotide sequences of monoclonal V(lambda) regions from 55 consecutive unselected cases of primary amyloidosis and the results were compared with the light-chain expression profile of polyclonal marrow plasma cells from 3 healthy donors (a total of 264 sequences). We demonstrated that: (1) the lambdaIII family is the most frequently used both in amyloidosis (47%) and in polyclonality (43%); (2) both conditions are characterized by gene restriction; (3) a very skewed repertoire is a feature of amyloidosis, because just 2 germline genes belonging to the lambdaIII and lambdaVI families, namely 3r (22% of cases, lambdaIII) and 6a (20%, lambdaVI), contributed equally to encode 42% of amyloid V(lambda) regions; (4) these same 2 gene segments have a strong association with amyloidosis if their prevalences are compared with those in polyclonal conditions (3r, 8.3%, P =.024; 6a, 2.3%, P =.0008, chi2 test); (5) the J(lambda)2/3 segment, encoding the fourth framework region, appears to be slightly overrepresented in AL (83% versus 67%, P =.03), and this might be related to preferential J(lambda)2/3 rearrangement in amyloid (11 of 12 cases) versus polyclonal 3r light chains (13 of 22 cases). These findings demonstrate that V(lambda)-J(lambda) expression is more restricted in plasma cells from amyloidosis than from polyclonal bone marrow and identify 3r as a new disease-associated gene segment. Overusage of just 2 gene segments, 3r and 6a, can thus account for the lambda light-chain overrepresentation typical of this disorder. PMID:12130507

Perfetti, Vittorio; Casarini, Simona; Palladini, Giovanni; Vignarelli, Maurizio Colli; Klersy, Catherine; Diegoli, Marta; Ascari, Edoardo; Merlini, Giampaolo

2002-08-01

330

ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli.  

PubMed

Genetic variation of the human ACE I/D and ACTN3 R577X polymorphisms subsequent to 12 weeks of high-speed power training on maximal strength (1RM) of the arm and leg muscles, muscle power performance (counter-movement jump), and functional capacity (sit-to-stand test) was examined in older Caucasian women [n?=?139; mean age 65.5 (8.2) years; 67.0 (10.0) kg and 1.57 (0.06) m]. Chelex 100 was used for DNA extraction, and genotype was determined by PCR-RFLP methods. Muscular strength, power, and functional testing were conducted at baseline (T1) and after 12 weeks (T2) of high-speed power training. At baseline, the ACE I/D and ACTN3 R/X polymorphisms were not associated with muscle function or muscularity phenotypes in older Caucasian women. After the 12-week high-speed training program, subjects significantly increased their muscular and functional capacity performance (p?3 R/X polymorphisms are likely factors in modulating exercise-related phenotypes in older women, particularly in response to a resistance training stimuli. PMID:22855367

Pereira, Ana; Costa, Aldo M; Izquierdo, Mikel; Silva, António J; Bastos, Estela; Marques, Mário C

2012-08-02

331

Band-gap variation in RScO3 (R=Pr, Nd, Sm, Eu, Gd, Tb, and Dy): X-ray absorption and O K-edge x-ray emission spectroscopies  

NASA Astrophysics Data System (ADS)

The electronic structure of rare-earth scandates RScO3 (R: newly studied Pr, Nd, Eu, and Tb, compared with previously studied Sm, Gd, and Dy) was analyzed by a combined use of O K absorption and emission spectroscopies and Sc L-edge absorption spectroscopy. This permitted the estimation of band gaps by use of a method that differed from optical measurements. The band-gap variation over the series in dependence on the rare-earth ion is analyzed, and a correlation between the Sc-O mean distance and the band gap is found and discussed.

Derks, C.; Kuepper, K.; Raekers, M.; Postnikov, A. V.; Uecker, R.; Yang, W. L.; Neumann, M.

2012-10-01

332

Gamma2-Melanocyte Stimulation Hormone (?2-MSH) Truncation Studies Results in the Cautionary Note that ?2-MSH is Not Selective for the Mouse MC3R over the Mouse MC5R  

PubMed Central

The melanocortin system has been implicated in a multitude of physiological pathways including obesity, satiety, energy homeostasis, sexual behavior, pigmentation, sodium regulation, hypertension, and many others. Based upon studies of the endogenous melanocortin receptor agonists at the cloned human melanocortin receptor proteins, it was concluded that the ?-MSH related agonist ligands are selective for the MC3 versus the MC4 and MC5 receptors. In attempts to understand and identify the specific amino acids of ?2-MSH important for MC3R selectivity, we have performed N- and C-terminal truncation studies and pharmacologically characterized twenty-eight ligands at the mouse MC1 and MC3-5 melanocortin receptors. The C-terminal Trp-Asp9-Arg10-Phe11 residues are important for nM potency at the mMC3R and the Arg7-Trp8 residues are important for mMC5R nM potency. We observed the unanticipated results that several of the C-terminal truncated analogues possessed nM agonist potency at the mMC3 and mMC5Rs which lead us to performed a comparative side-by-side study of the mouse and human MC5R. These data resulted in ?M ?2-MSH analogue potency at the hMC5R, consistent with previous reports, however at the mMC5R, nM ?2-MSH analogue potency was observed. Thus, these data support the hypothesis of important species specific differences in ?-MSH related ligand potency at the rodent versus human MC5R subtype that is critical for the interpretation of in vivo rodent physiological studies. These results prompted us to examine the affects of a peripherally administered melanocortin agonist on hypothalamic gene expression levels of the MC3R, MC4R, and MC5R. The super potent non-selective NDP-MSH agonist was administered i.p. and resulted in significantly decreased levels of mMC3R and mMC5R hypothalamic mRNA versus saline control. These data provide for the first time data demonstrating peripherally administered NDP-MSH can modify hypothalamic melanocortin receptor expression levels.

Joseph, Christine G.; Yao, Hua; Scott, Joseph W.; Sorensen, Nicholas B.; Marnane, Rebecca N.; Mountjoy, Kathleen G.; Haskell-Luevano, Carrie

2010-01-01

333

A Monte Carlo simulation for the stripping of the Square_Root3 x[Square_Root]3 R30[deg] alkanethiol lattice from Au(111) terraces and steps  

NASA Astrophysics Data System (ADS)

Monte Carlo simulations of a model for the stripping of Square_Root3 xSquare_Root3 R30deg alkanethiol lattices from terraces and steps of a (111) metal face in aqueous solutions are presented. In the model the stripping probability of an adsorbed alkanethiolate molecule depends on the applied potential, on intermolecular forces that stabilize the alkanethiol layer, and on the presence of substrate defects. Stabilizing intermolecular forces are also responsible for alkanethiolate aggregate formation during the stripping process. Snapshots and voltammograms derived from the model reproduce experimental STM images and electrochemical data for alkanethiol stripping from the Au(111) surface.

Martin, H.; Vericat, C.; Andreasen, G.; Vela, M. E.; Salvarezza, R. C.

2002-08-01

334

Enantioselective extraction of d,l-tryptophan by a new chiral selector: Complex formation with di(2-ethylhexyl)phosphoric acid and O,O?-dibenzoyl-(2 R,3 R)-tartaric acid  

Microsoft Academic Search

The paper presents a new complex chiral selector of di(2-ethylhexyl)phosphoric acid (D2EHPA) and O,O?-dibenzoyl-(2R,3R)-tartaric acid ((?)-DBTA) and its enantioselectivity on d,l-tryptophan (Trp). The influence of the initial concentration of d,l-Trp, (?)-DBTA, D2EHPA were studied. Both the distribution ratio and enantioselectivity of d,l-Trp are greatly improved with the complex extractant instead of (?)-DBTA individually. It was also found that the enantioselectivity

Bin Tan; GuangSheng Luo; Xuan Qi; JiaDing Wang

2006-01-01

335

Manganese 3×3 and 3×3-R30? structures and structural phase transition on w-GaN(0001¯) studied by scanning tunneling microscopy and first-principles theory  

NASA Astrophysics Data System (ADS)

Manganese deposited on the N-polar face of wurtzite gallium nitride [GaN (0001¯)] results in two unique surface reconstructions, depending on the deposition temperature. At lower temperature (less than 105?C), it is found that a metastable 3×3 structure forms. Mild annealing of this Mn 3×3 structure leads to an irreversible phase transition to a different, much more stable 3×3-R30? structure which can withstand high-temperature annealing. Scanning tunneling microscopy (STM) and reflection high-energy electron diffraction data are compared with results from first-principles theoretical calculations. Theory finds a lowest-energy model for the 3×3 structure consisting of Mn trimers bonded to the Ga adlayer atoms but not with N atoms. The lowest-energy model for the more stable 3×3-R30? structure involves Mn atoms substituting for Ga within the Ga adlayer and thus bonding with N atoms. Tersoff-Hamman simulations of the resulting lowest-energy structural models are found to be in very good agreement with the experimental STM images.

Chinchore, Abhijit V.; Wang, Kangkang; Shi, Meng; Mandru, Andrada; Liu, Yinghao; Haider, Muhammad; Smith, Arthur R.; Ferrari, Valeria; Barral, Maria Andrea; Ordejón, Pablo

2013-04-01

336

Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?  

PubMed

We investigated the association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism, alone or in combination with the ?-actinin-3 gene (ACTN3) R577X polymorphism, with jumping (vertical squat and counter-movement jump tests) and sprint ability (30 m dash) in non-athletic, healthy young adults [N = 281 (214 male), mean (SD) age 21 (2) years]. We did not observe any effect of the ACE I/D polymorphism on study phenotypes. We repeated the analyses separately in men and women and the results did not materially change. Likewise, the mean estimates of the study phenotypes were similar in subjects with the genotype combinations ACE II + ID and ACTN3 XX or ACE DD and ACTN3 RR + RX. We found no association between the ACE DD and ACTN3 RR + RX genotype combination and performance (?90th of the sex-specific percentile). In summary, though the ACE I/D polymorphism is a strong candidate to modulate some exercise-related phenotypes or athletic performance status, this polymorphism, alone or in combination with the ACTN3 R577X polymorphism, does not seem to exert a major influence in the muscle 'explosive' power of young healthy adults, as assessed during multi-joint exercise tests. PMID:20734058

Rodríguez-Romo, Gabriel; Ruiz, Jonatan R; Santiago, Catalina; Fiuza-Luces, Carmen; González-Freire, Marta; Gómez-Gallego, Félix; Morán, María; Lucia, Alejandro

2010-08-24

337

Ricebean: a multipurpose underutilised legume  

Microsoft Academic Search

Summary Ricebean (Vigna umbellata) is a neglected legume regarded as a minor food and fodder crop in Nepal and northern India, and grown in a range of cropping systems with maize during summer, as a sole crop in the uplands, on rice bunds or in home gardens. It is mainly grown for human consumption, though it is also used for

KD Joshi; B Bhandari; R Gautam; J Bajracharya; PA Hollington

338

The Multi-Purpose Astrolabe.  

ERIC Educational Resources Information Center

Directions are given for construction of an astrolabe capable of yielding two celestial coordinates: altitude and azimuth. Potential uses are included for both young and older children. Quantitative measurement activities related to celestial motion and position are given. (SA)

Neie, Van E.

1979-01-01

339

PLT: a multipurpose plotting package  

SciTech Connect

PLT is a device independent plotting package developed under the ARIES project in Department 1530. It is built on top of the Sandia Virtual Device Interface (VDI) and therefore supports many different devices. The capabilities of the package include basic plotting primitives, clipping subroutines, color, element plotting routines, software and hardware text, two dimensional graph plotting, mapping subroutines and routines to set various PLT parameters. PLT is coded in RATFOR, a FORTRAN preprocessor and is currently supported on VAX/VMS.

Selleck, C.B.; Sears, M.P.

1983-08-01

340

Agribot — A multipurpose agricultural robot  

Microsoft Academic Search

Agribot is a robot designed for agricultural purposes. It is designed to minimize the labor of farmers in addition to increasing the speed and accuracy of the work. It performs the elementary functions involved in farming i.e. ploughing the field, sowing of seeds and covering the seeds with soil. The robot is autonomous and provides the facility for optional switching

Akhila Gollakota; M. B. Srinivas

2011-01-01

341

Enantiomeric composition of (3R)-(-)- and (3S)-(+)-linalool in various essential oils of Indian origin by enantioselective capillary gas chromatography-flame ionization and mass spectrometry detection methods.  

PubMed

Enantiomeric ratios of linalool have been determined in various authentic essential oils of Indian origin using 10% heptakis(2,3-di-O-methyl-6-O-tert-butyldimethylsilyl)-beta-cyclodextrin as a chiral stationary phase. A complete enantiomeric excess (ee) for (3S)-(+)-linalool was characteristic of Lippia alba and Cinnamomum tamala leaf oils while less than 90% excess was noticed in Zanthoxylum armatum leaf, Zingiber roseum root/rhizome and Citrus sinensis leaf oils. On the contrary, an enantiomeric excess of (3R)-(-)-linalool characterizes essential oils of basil (100% for Ocimum basilicum) and bergamot mint (72 to 75% for Mentha citrata). Notably, some essential oils containing both enantiomers in equal ratios or in racemic forms are rose, geranium, lemongrass and Origanum. The enantiomeric composition studies are discussed as indicators of origin authenticity and quality of essential oil of Indian origin. PMID:19476006

Chanotiya, Chandan S; Yadav, Anju

2009-04-01

342

Sex Pheromone of the Pine Sawfly Macrodiprion nemoralis (Hymenoptera : Diprionidae): Identification of (2S,3R,7R,9S)-3,7,9-Trimethyl-2-tridecanol as the Precursor for the Active Pheromone Acetate  

NASA Astrophysics Data System (ADS)

The main component of the sex pheromone precursor in females of Macrodiprion nemoralis was identified as a threo-3,7,9-trimethyl-2-tridecanol isomer, approximately 800pg per female, by gas chromatography-mass spectrometry. Comparison of mass spectrometric ion chromatograms showed that the natural compound in the female extract has the same retention time and mass spectrum as one of the two synthetic threo peaks. The acetate of the synthetic 16-isomer mixture caught a large number of males in the field, confirming the structure of the active pheromone. Comparison of gas chromatograms of the natural female extract with the eight synthetic threo stereoisomers showed that the pheromone is the (2S,3R,7R,9S)-stereoisomer of 3,7,9-trimethyl-2-tridecyl acetate.

Wassgren, A.-B.; Bergström, G.; Sierpinski, A.; Anderbrant, O.; Högberg, H.-E.; Hedenström, E.

343

Myocardial accumulation of iodinated beta-methyl-branched fatty acid analogue, iodine-125-15-(p-iodophenyl)-3-(R,S)methylpentadecanoic acid (BMIPP), in relation to ATP concentration  

SciTech Connect

To clarify the relationship between the myocardial accumulation of {sup 125}I-15-(p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP) and intracellular adenosine-5'-triphosphate (ATP) content, the effect of 2,4-dinitrophenol (DNP, an electron transport uncoupler) on myocardial BMIPP accumulation was studied, in comparison with that of thallium-201-chloride ({sup 201}Tl-Cl). In the mouse myocardium, DNP decreased the intracellular ATP and ADP levels, without affecting either acyl-CoA synthetase activity or the level of CoA-SH. Following treatment with DNP, decreases in myocardial BMIPP accumulation correlated well with those of ATP, while {sup 201}Tl-Cl showed slightly increased accumulation in the myocardium. Thus, in some diseases, BMIPP may be useful in evaluating myocardial ATP levels.

Fujibayashi, Y.; Yonekura, Y.; Takemura, Y.; Wada, K.; Matsumoto, K.; Tamaki, N.; Yamamoto, K.; Konishi, J.; Yokoyama, A. (Kyoto Univ. (Japan))

1990-11-01

344

First-principles investigation of R{sub 2}O{sub 3}(ZnO){sub 3} (R=Al, Ga, and In) in homologous series of compounds  

SciTech Connect

Atomic and electronic structures of R{sub 2}O{sub 3}(ZnO){sub 3} (R=Al, Ga, and In), which are included in homologous series of compounds, are investigated using first-principles calculations based on density functional theory. Three models with different R atom arrangements in the five-fold and four-fold coordination sites are examined. Al and Ga prefer the five-fold coordination sites. The formation energies are much larger than those of the competing phases, ZnR{sub 2}O{sub 4}, with a normal spinel structure. On the other hand, In{sub 2}O{sub 3}(ZnO){sub 3} shows no clear site preference and can be more stable than the spinel at high temperatures when configurational entropy contribution is taken into account. Electronic states near the conduction band bottom are mainly composed of Zn-4s orbital in Al{sub 2}O{sub 3}(ZnO){sub 3}, while the contributions of Ga-4s and In-5s are comparable to Zn-4s in Ga{sub 2}O{sub 3}(ZnO){sub 3} and In{sub 2}O{sub 3}(ZnO){sub 3}. - Graphical abstract: R{sub 2}O{sub 3}(ZnO){sub 3} (R=Al, Ga, and In) in homologous series of compounds are investigated using first-principles calculations with special interest on preferred occupation sites of R, relative energetics with competing phases and electronic structures.

Yoshioka, Satoru [Department of Materials Science and Engineering, Kyoto University, Sakyo, Kyoto 606-8501 (Japan)], E-mail: syoshioka@nucl.kyushu-u.ac.jp; Toyoura, Kazuaki; Oba, Fumiyasu; Kuwabara, Akihide; Matsunaga, Katsuyuki; Tanaka, Isao [Department of Materials Science and Engineering, Kyoto University, Sakyo, Kyoto 606-8501 (Japan)

2008-01-15

345

C-C and C-Heteroatom Bond Dissociation Energies in CH3R?C(OH)2: Energetics for Photocatalytic Processes of Organic Diolates on TiO2 Surfaces  

SciTech Connect

The bond energies of a range of gem-diols, CH3R?C(OH)2 (R? = H, F, Cl, Br, CN, NO2, CF3, CH3CH2, CH3CH2CH2, CH3CH2CH2CH2, ((CH3)2)CH, (CH3)3C, ((CH3)2CH)CH2, (CH3CH2)(CH3)CH, C6H5 (CH3CH2)(CH3)CH) which serve as models for binding to a surface have been studied with density functional theory (DFT) and the molecular orbital G3(MP2) methods to provide thermodynamic data for the analysis of the photochemistry of ketones on TiO2. The ultraviolet (UV) photon-induced photodecomposition of adsorbed acetone and 3,3-dimethylbutanone on the rutile TiO2 (110) surface have been investigated with photon stimulated desorption (PSD) and temperature programmed desorption (TPD). The C-CH3 and C-C(R?) bond dissociation energies in CH3R?C(OH)2 were predicted, and our calculated bond dissociation energies are in excellent agreement with the available experimental values. We used a series of isodemic reactions to provide small corrections to the various bond dissociation energies. The calculated bond dissociation energies are in agreement with the observed photodissociation processes except for R? = CF3, suggesting that these processes are under thermodynamic control. For R? = CF3, reaction dynamics also play a role in determining the photodissociation mechanism. The gas phase Brönsted acidities of the gem-diols were calculated. For three molecules, R? = Cl, Br, and NO2, loss of a proton leads to the formation of a complex of acetic acid with the anion Cl-, Br-, and NO2-. The acidities of these three species are very high with the former two having acidities comparable to CF3SO3H. The ketones (R?RC(=O)) are weak Lewis acids except where addition of OH- leads to the dissociation of the complex to form an anion bonded to acetic acid, R' = NO2, Cl, and Br. The X-C bond dissociation energies for a number of X-CO2- species were calculated and these should be useful in correlating with photochemical reactivity studies.

Wang, Tsang-Hsiu; Dixon, David A.; Henderson, Michael A.

2010-08-26

346

ATPA induced GluR5-containing kainite receptor S-nitrosylation via activation of GluR5-Gq-PLC-IP(3)R pathway and signalling module GluR5·PSD-95·nNOS.  

PubMed

GluR5-containing kainite receptor (GluR5-KAR) plays an important role in the pathophysiology of nervous system diseases, while S-nitrosylation exerts a variety of effects on biological systems. However, the mechanism of GluR5-KAR S-nitrosylation is still unclear up to now. Here our researches found that GluR5-KAR selective agonist ATPA stimulation activated the nonclassical GluR5-KAR-Gq-PLC-IP(3)R pathway and the signalling module GluR5·PSD-95·nNOS (the former is more important), led to Ca(2+) release from intracellular calcium stores endoplasmic reticulum (ER) to cytoplasm and extracellular calcium indrawal, respectively, which further resulted in nNOS activation and GluR5-KAR S-nitrosylation, and then inhibited GluR5-mediated whole-cell current attenuation and induced apoptosis in primary cultured hippocampal neurons. Clarification of the primary mechanisms of GluR5-KAR S-nitrosylation induced by ATPA and identification of critical cysteine for GluR5-2a S-nitrosylation (Cys231 and Cys804) open up a brand-new field for revealing downstream signalling pathway of GluR5-KAR and its molecular characteristics, exploring the pathogenesis of neurological diseases and searching for promising therapies. PMID:23000395

Zhang, Hai-Jian; Li, Chong; Zhang, Guang-Yi

2012-09-20

347

Here to stay: Stability and structure of (6?3x6?3)-R30^o graphene on SiC(111) by all-electron DFT including van der Waals effects  

NASA Astrophysics Data System (ADS)

SiC is a favorite growth substrate for mono- and few-layer graphene by Si sublimation. On the Si side, large ordered graphene areas can be obtained as commensurate (6?3x6?3)-R30^o (``6?3'') periodic films [1]. From a thermodynamic perspective, graphene formation competes with several other phases, including graphite on one side, and several Si-rich reconstructions on the other. The question whether 6?3 graphene on SiC(111) is thermodynamically or just kinetically stabilized could be answered by density functional theory (DFT) calculations but for two challenges: (1) The needed surface slab systems are extremely large (up to 2000 atoms in this work), and (2) most standard DFT functionals do not include van der Waals effects. We here show by all-electron DFT including van der Waals effects (PBE+vdW [2]) that the 6?3 graphene-like phases on SiC(111) are thermodynamically stable compared to competing surface phases, and obtain the full structure including the substrate-induced graphene corrugation. The impact of strain in smaller-cell approximants and that of possible graphene defects is discussed. [1] K. Emtsev et al., Nature Materials 8, 203 (2009). [2] A. Tkatchenko, M. Scheffler, PRL 102, 073005 (2009).

Blum, Volker; Nemec, Lydia; Rinke, Patrick; Scheffler, Matthias

2012-02-01

348

The D prostanoid receptor agonist BW245C [(4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid] inhibits fibroblast proliferation and bleomycin-induced lung fibrosis in mice.  

PubMed

Prostaglandin (PG) D(2) exerts contrasting activities in the inflamed lung via two receptors, the D prostanoid receptor (DP) and the chemoattractant receptor-homologous molecule expressed on T helper 2 lymphocytes. DP activation is known mainly to inhibit proinflammatory cell functions. We tested the effect of a DP-specific agonist, (4S)-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid (BW245C), on pulmonary fibroblast functions in vitro and in a mouse model of lung fibrosis induced by bleomycin. DP mRNA expression was detected in cultured mouse lung primary fibroblasts and human fetal lung fibroblasts and found to be up- and down-regulated by interleukin-13 and transforming growth factor (TGF)-?, respectively. Although micromolar concentrations of BW245C and PGD(2) did not affect mouse fibroblast collagen synthesis or differentiation in myofibroblasts, they both inhibited fibroblast basal and TGF-?-induced proliferation in vitro. The repeated administration of BW245C (500 nmol/kg body weight instilled transorally in the lungs 2 days before and three times per week for 3 weeks) in bleomycin-treated mice significantly decreased both inflammatory cell recruitment and collagen accumulation in the lung (21 days). Our results indicate that BW245C can reduce lung fibrosis in part via its activity on fibroblast proliferation and suggest that DP activation should be considered as a new therapeutic target in fibroproliferative lung diseases. PMID:20719937

van den Brule, Sybille; Wallemme, Laurent; Uwambayinema, Francine; Huaux, François; Lison, Dominique

2010-08-18

349

Synthesis and application of (13)C-labeled 2-acetyl-4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)imidazole (THI), an immunosuppressant observed in caramel food colorings.  

PubMed

2-Acetyl-4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)imidazole (THI) is a minor toxic contaminant observed in caramel food colorings and was shown to exert immunosuppressant activity when fed to rodents. Because of this toxicity, maximum levels of THI in caramel food colorings have been defined by international and European authorities. Several reports of THI analysis using external standardization have been published for liquid foods such as beers and soft drinks. However, no suitable internal standard has yet been described allowing THI analysis in more complex samples. In this paper we describe the preparation of a labeled [(13)C6]THI analogue and its application for the successful validation of the first stable isotope dilution assay (SIDA) of THI in caramel food colorings. A brief survey of THI levels in commercially available caramel class III (E 150c) and IV (E 150d) food colorings is also included, corroborating that THI occurs only in caramel class III food colorings. PMID:23866086

Elsinghorst, Paul W; Raters, Marion; Dingel, Anna; Fischer, Jochen; Matissek, Reinhard

2013-07-29

350

Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription  

PubMed Central

Histone acetylation is a hallmark for gene transcription. As a histone acetyltransferase, MOZ (monocytic leukemia zinc finger protein) is important for HOX gene expression as well as embryo and postnatal development. In vivo, MOZ forms a tetrameric complex with other subunits, including several chromatin-binding modules with regulatory functions. Here we report the solution structure of the tandem PHD (plant homeodomain) finger (PHD12) of human MOZ in a free state and the 1.47 Å crystal structure in complex with H3K14ac peptide, which reveals the structural basis for the recognition of unmodified R2 and acetylated K14 on histone H3. Moreover, the results of chromatin immunoprecipitation (ChIP) and RT–PCR assays indicate that PHD12 facilitates the localization of MOZ onto the promoter locus of the HOXA9 gene, thereby promoting the H3 acetylation around the promoter region and further up-regulating the HOXA9 mRNA level. Taken together, our findings suggest that the combinatorial readout of the H3R2/K14ac by PHD12 might represent an important epigenetic regulatory mechanism that governs transcription and also provide a clue of cross-talk between the MOZ complex and histone H3 modifications.

Qiu, Yu; Liu, Lei; Zhao, Chen; Han, Chuanchun; Li, Fudong; Zhang, Jiahai; Wang, Yan; Li, Guohong; Mei, Yide; Wu, Mian; Wu, Jihui; Shi, Yunyu

2012-01-01

351

Large electric polarization in high pressure synthesized orthorhombic manganites RMnO3 (R=Ho,Tm,Yb and Lu) by using the double-wave PE loop measurements  

NASA Astrophysics Data System (ADS)

The magnitude of electric polarization via the conventional pyroelectric current and/or PE loop measurements often is ambiguous due to resistive components of the sample. To avoid this, a new technique called the double-wave method has been recently developed [1], in which only hysteretic PE components can be measured. Using this technique, we have measured the ferroelectric polarization of the orthorhombic RMnO3 (R=Ho, Tm, Yb, and Lu) synthesized under high pressure. Large remnant polarization Pr up to 920 ?C/m^2 is observed at 10 K for LuMnO3. Furthermore, the Pr vs. temperature data from the PE loop has shown consistency with that measured through the pyroelectric current measurements, supporting a theoretical prediction of large polarization in the E-type spin structure in this system [2]. We also discuss the influence of thermal histories on the ferroelectric domain dynamics and possible internal bias field effects originating from oxygen vacancies in RMnO3. [1] M. Fukunaga, et al. J. Phys. Soc. Jpn. 77, 064706 (2008). [2] I. A. Sergienko, et al. Phys. Rev. Lett., 97, 227204 (2006)

Chai, Y. S.; Oh, Y. S.; Manivannan, N.; Yang, Y. S.; Kim, Kee Hoon; Feng, S. M.; Wang, L. J.; Jin, C. Q.

2009-03-01

352

The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).  

PubMed

Biochemical and genetic studies implicate synaptotagmin (Syt 1) as a Ca2+ sensor for neuronal and neuroendocrine neurosecretion. Calcium binding to Syt 1 occurs through two cytoplasmic repeats termed the C2A and C2B domains. In addition, the C2A domain of Syt 1 has calcium-independent properties required for neurotransmitter release. For example, mutation of a polylysine motif (residues 189-192) reverses the inhibitory effect of injected recombinant Syt 1 C2A fragment on neurotransmitter release from PC12 cells. Here we examined the requirement of the C2A polylysine motif for Syt 1 interaction with the cardiac Cav1.2 (L-type) and the neuronal Cav2.3 (R-type) voltage-gated Ca2+ channels, two channels required for neurotransmission. We find that the C2A polylysine motif presents a critical interaction surface with Cav1.2 and Cav2.3 since truncated Syt 1 containing a mutated motif (Syt 1*1-264) was ineffective at modifying the channel kinetics. Mutating the polylysine motif also abolished C2A binding to Lc753-893, the cytosolic interacting domain of Syt 1 at Cav1.2 1 subunit. Syt 1 and Syt 1* harboring the mutation at the KKKK motif modified channel activation, while Syt 1* only partially reversed the syntaxin 1A effects on channel activity. This mutation would interfere with the assembly of Syt 1/channel/syntaxin into an exocytotic unit. The functional interaction of the C2A polylysine domain with Cav1.2 and Cav2.3 is consistent with tethering of the secretory vesicle to the Ca2+ channel. It indicates that calcium-independent properties of Syt 1 regulate voltage-gated Ca2+ channels and contribute to the molecular events underlying transmitter release. PMID:12645522

Cohen, Roy; Elferink, Lisa A; Atlas, Daphne

2003-03-14

353

Sub-plasmalemmal [Ca2+]i upstroke in myocytes of the guinea-pig small intestine evoked by muscarinic stimulation: IP3R-mediated Ca2+ release induced by voltage-gated Ca2+ entry  

PubMed Central

Membrane depolarization triggers Ca2+ release from the sarcoplasmic reticulum (SR) in skeletal muscles via direct interaction between the voltage-gated L-type Ca2+ channels (the dihydropyridine receptors; VGCCs) and ryanodine receptors (RyRs), while in cardiac muscles Ca2+ entry through VGCCs triggers RyR-mediated Ca2+ release via a Ca2+-induced Ca2+ release (CICR) mechanism. Here we demonstrate that in phasic smooth muscle of the guinea-pig small intestine, excitation evoked by muscarinic receptor activation triggers an abrupt Ca2+ release from sub-plasmalemmal (sub-PM) SR elements enriched with inositol 1,4,5-trisphosphate receptors (IP3Rs) and poor in RyRs. This was followed by a lesser rise, or oscillations in [Ca2+]i. The initial abrupt sub-PM [Ca2+]i upstroke was all but abolished by block of VGCCs (by 5 ?M nicardipine), depletion of intracellular Ca2+ stores (with 10 ?M cyclopiazonic acid) or inhibition of IP3Rs (by 2 ?M xestospongin C or 30 ?M 2-APB), but was not affected by block of RyRs (by 50–100 ?M tetracaine or 100 ?M ryanodine). Inhibition of either IP3Rs or RyRs attenuated phasic muscarinic contraction by 73%. Thus, in contrast to cardiac muscles, excitation–contraction coupling in this phasic visceral smooth muscle occurs by Ca2+ entry through VGCCs which evokes an initial IP3R-mediated Ca2+ release activated via a CICR mechanism.

Gordienko, D.V.; Harhun, M.I.; Kustov, M.V.; Pucovsky, V.; Bolton, T.B.

2008-01-01

354

Theoretical study of Pt(PR3)(2)(AlCl3) (R = H, Me, Ph, or Cy) including an unsupported bond between transition metal and non-transition metal elements: geometry, bond strength, and prediction.  

PubMed

The molecular structure and the binding energy of Pt(PR(3))(2)(AlCl(3)) (R = H, Me, Ph, or Cy) were investigated by DFT, MP2 to MP4(SDTQ), and CCSD(T) methods. The optimized structure of Pt(PCy(3))(2)(AlCl(3)) (Cy = cyclohexyl) by the DFT method with M06-2X and LC-BLYP functionals agrees well with the experimental one. The MP4(SDTQ) and CCSD(T) methods present similar binding energies (BE) of Pt(PH(3))(2)(AlCl(3)), indicating that these methods provide reliable BE value. The DFT(M06-2X)-calculated BE value is close to the MP4(SDTQ) and CCSD(T)-calculated values, while the other functionals present BE values considerably different from the MP4(SDTQ) and CCSD(T)-calculated values. All computational methods employed here indicate that the BE values of Pt(PMe(3))(2)(AlCl(3)) and Pt(PPh(3))(2)(AlCl(3)) are considerably larger than those of the ethylene analogues. The coordinate bond of AlCl(3) with Pt(PR(3))(2) is characterized to be the ? charge transfer (CT) from Pt to AlCl(3). This complex has a T-shaped structure unlike the well-known Y-shaped structure of Pt(PMe(3))(2)(C(2)H(4)), although both are three-coordinate Pt(0) complex. This T-shaped structure results from important participation of the Pt d(?) orbital in the ?-CT; because the Pt d(?) orbital energy becomes lower as the P-Pt-P angle decreases, the T-shaped structure is more favorable for the ?-CT than is the Y-shaped structure. [Co(alcn)(2)(AlCl(3))](-) (alcn = acetylacetoneiminate) is theoretically predicted here as a good candidate for the metal complex, which has an unsupported M-Al bond because its binding energy is calculated to be much larger than that of Pt(PCy(3))(2)(AlCl(3)). PMID:21710982

Tsukamoto, Shinya; Sakaki, Shigeyoshi

2011-07-13

355

Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R).  

PubMed

The melanocortin-3 (MC3) and melanocortin-4 (MC4) receptors regulate energy homeostasis, food intake, and associated physiological conditions. The melanocortin-4 receptor (MC4R) has been studied extensively. Less is known about specific physiological roles of the melanocortin-3 receptor (MC3R). A major obstacle to this lack of knowledge is attributed to a limited number of identified MC3R selective ligands. We previously reported a spatial scanning approach of a 10-membered thioether-heterocycle ring incorporated into a chimeric peptide template that identified a lead nM MC4R ligand. Upon the basis of those results, 17 compounds were designed and synthesized that focused upon modification in the pharmacophore domain. Notable results include the identification of a 0.13 nM potent 5800-fold mMC3R selective antagonist/slight partial agonist versus a 760 nM mMC4R full agonist (ligand 11). Biophysical experiments (two-dimensional (1)H NMR and computer-assisted molecular modeling) of this ligand resulted in the identification of an inverse ?-turn secondary structure in the ligand pharmacophore domain. PMID:23432160

Singh, Anamika; Dirain, Marvin; Witek, Rachel; Rocca, James R; Edison, Arthur S; Haskell-Luevano, Carrie

2013-03-25

356

HNV-3D: Multipurpose Head Mounted Display.  

National Technical Information Service (NTIS)

HNV-3D stand for Holographic Night Vision goggles with 3 Dimensional vision perception and sensor fusion. They have been especially developed for the advanced future needs of individual soldiers, drivers, special forces, helicopter crew, The lightweight H...

1999-01-01

357

Multi-Purpose Laser Diode Modules.  

National Technical Information Service (NTIS)

Butterfly- and DIP-packaged semiconductor laser diode modules with single mode fiber pigtail have been developed, as the light sources for optical fiber telecommunication systems ranging from high bitrate and long-haul trunk lines to short-haul junction l...

N. Shibanuma Y. Ohshima K. Kosuge T. Ogawa M. Shikada

1987-01-01

358

Sustainable multipurpose tree production systems for Nepal  

SciTech Connect

Argonne National Laboratory is developing methods for producing reforestation plating stock, fuel, and fodder in a sustainable manner in Nepal. This project, in cooperation with the Ministry of Forest and Soil Conservation of Nepal, is sponsored by the US Agency for International Development (AID). Several production systems are being evaluated for the Mid-Hills Region of Nepal. To provide sustainable biomass production and ecological management of the fragile Mid-Hills Region, the production systems must simultaneously satisfy the physiological requirements of the plants, the symbiotic requirements of the plant and the microorganisms in its rhizosphere, the physicochemical requirements of nutrient and water cycling, and the climatic and topographic constraints.

Shen, S.Y.; Kilpatrick, K.J.

1988-03-01

359

7 CFR 3201.57 - Multipurpose lubricants.  

Code of Federal Regulations, 2013 CFR

...this item. In addition, task-specific lubricants, such as chain and cable lubricants and gear lubricants, are not included in this item. (b...of at least 88 percent, which shall be based on the amount of qualifying biobased...

2013-01-01

360

Solar Powered Multipurpose Remotely Powered Aircraft.  

National Technical Information Service (NTIS)

Increase in energy demands coupled with rapid depletion of natural energy resources have deemed solar energy as an attractive alternative source of power. The focus was to design and construct a solar powered, remotely piloted vehicle to demonstrate the f...

A. N. Alexandrou W. W. Durgin R. F. Cohn D. J. Olinger C. K. Cody

1992-01-01

361

DEVELOPMENT OF THE MULTIPURPOSE THERMAL SPRAYING SYSTEM  

Microsoft Academic Search

Many components and structures require protection against corrosion, oxidization, excessive heat and wear. This is achieved by applying various types of coatings on the component base material, hence providing the necessary protection and improving performance of aircraft systems. For example, the application of the thermal barrier coatings (TBC), in the last decade, on the aircraft turbine blades, vanes and combustors

Igor A. Gorlach; Daniela Ghelase; Nelson Mandela

362

A Multipurpose Experiment with an Electronic Balance  

ERIC Educational Resources Information Center

|This short article describes some useful and quick applications of a cooking electronic balance. Newton's third law, Archimedes buoyancy and an estimate of relative density are accomplished in a very simple way. (Contains 1 figure.)|

Ganci, S.

2008-01-01

363

A Multipurpose Device for Some Hydrostatics Questions  

ERIC Educational Resources Information Center

|A number of well-known hydrostatics problems dealing with Archimedes' principle concern a loaded boat floating in a pool. Examples of this sort of problem include: 1. (a) If a stone is thrown overboard from a boat floating in a pool, does the water level in the pool rise, fall, or remain unchanged? (b) If a hole is made in the bottom of the boat…

Ganci, Salvatore

2008-01-01

364

The Multi-Purpose Library Computer Lab  

Microsoft Academic Search

Within today's academic libraries, computer labs are designed and built to satisfy multiple needs, such as an open lab, instructional facility, and staff development center. To accomplish this, it is necessary to focus on issues concerning staffing, scheduling, security, and maintenance, as well as address the conflicts that often arise among them. Learn how Rider University has successfully operated and

Robert J. Lackie; Edward M. Corrado

2001-01-01

365

Multipurpose Projectile for Penetrating Urban Targets.  

National Technical Information Service (NTIS)

The U.S. Army Research Laboratory at the Aberdeen Proving Ground, MD is interested in developing a thin-walled munition capable of perforating an urban structure and delivering a payload intact to the interior of the structure. One of the most critical de...

B. R. Sorensen I. R. Phillabaum R. E. Moxley R. L. Summers S. J. Schraml

2007-01-01

366

Microbolometer spectrometer, the multipurpose smallsat instrument  

NASA Astrophysics Data System (ADS)

Due to lower mass, size and power demands and recognized increased reliability, microbolometer detectors seem to be well suited for small sattelite applications. Due to the improving technical performance, next generation instruments can use uncooled microbolometer arrays without significantly sacrificing performance. An example of this type of instruments is a hyper spectral imager called Micro Bolometer Spectrometer MIBS, which is being developed by TNO TPD. By optimizing the throughput of the optical system, and using the latest improvements in detector performance, TNO TPD has been able to design a spectrometer that is able to provide co-registered measurements in the 7 to 14 ?m wavelength region resulting in an acceptable NETD performance on the basis of currently available standard detectors. Through further developments, it is expected that detectors with even lower NETD will become available in the future. Apart from the usual multispectral imaging in the thermal infrared atmospheric window, the concept can be used for several other applications, for example CO2 monitoring due to the broader spectral response. The removal of the highpass filter, which is typically integrated on the window of the currently available bolometer detectors, allows imaging in the range from 2 to beyond 15 ?m. This enables an instrument to perform a number of simultaneous tasks like atmospheric and disaster monitoring. A number of applications would benefit from high temporal coverage, which can only be provided in an economical fashion by the use of mini or micro satellites. Due to the limited size of the instrument, MIBS is well suited for application on a microsatellite.

Leijtens, J.; Court, A.; de Boom, K.

2004-11-01

367

HIGH-TEMP MULTI-PURPOSE GREASE  

Microsoft Academic Search

AP-1W AP-1W contains oxidation inhibitors, boundary lubricants, corrosion inhibitors and metal deactivators. It offers posi- tive protection for extreme services, which require heavy duty lubricant performance. JET JET JET JET JET-L -L -L -L -LUBE' UBE' UBE' UBE' UBE's s s s s AP-1W AP-1W AP-1W AP-1W AP-1W is recommended for anti-friction bearings, ball and roller bearings, sleeve bearings, jour-

CTERISTICS CTERISTICS

368

An advanced multipurpose dental adhesive system  

Microsoft Academic Search

An advanced dental adhesive system, composed of acrylic monomers and coupling agents, characterized by high tensile bond strength, enhanced durability, and biocompatibility was developed. The adhesive composition is curable chemically (self curing) or by visible light. This adhesive composition can be used for bonding to various substrates such as dentin, enamel, precious and nonprecious alloys, 'fresh' and 'set' amalgam, porcelain,

I. Eppelbaum; H. Dodiuk; S. Kenig; B. Zalsman; A. Valdman

1995-01-01

369

Quarkonia as a multi-purpose tool  

SciTech Connect

Quarkonia can be a very useful tool for understanding the medium in which they are produced and pass through. However, their usefulness as a tool depends on how well certain aspects of their behavior in cold matter are understood.

Vogt, R

2010-12-21

370

Vocational Services within a Large Multipurpose Agency.  

ERIC Educational Resources Information Center

|The history of services offered by the Royal Victorian Institute for the Blind in Melbourne, Australia, is traced. Features of institute services include client involvement in vocational decision making, a variety of segregated and integrated services, and maintenance of a Tertiary Resource Service which produces study material for novel areas of…

Davidson, T.

1990-01-01

371

Architecture for a multipurpose guideline execution engine.  

PubMed

Integration of guideline knowledge into the clinical workflow is essential, for improving adherence to guidelines. Guidelines in structured formats can be utilized by computer programs to provide decision support in clinical information systems, as well as to facilitate workflow. We have designed an architecture for a flexible guideline execution engine that can be utilized in clinical decision support applications. The engine may be utilized for other applications such as referral management, medical education, and conducting clinical trials. The engine executes guidelines that are defined in an extension of the Guideline Interchange Format (GLIF). GLIF was extended to support representation of constructs that are essential to the execution of the guideline. A prototype of the engine was implemented based on this architecture. The engine is being utilized in two clinical applications that draw on guidelines for decision support. The engine was also used for developing an educational application aimed at testing knowledge of guideline recommendations. PMID:10566450

Boxwala, A A; Greenes, R A; Deibel, S R

1999-01-01

372

Confronting Global Issues: A Multipurpose IR Simulation  

ERIC Educational Resources Information Center

|This article describes an international relations simulation that focuses on threats of transnational insurgent organizations, the future of the Iraqi regime, and the effect of globalization on foreign policies. It contains both the Simulation Director's Guide and the Participant's Guide. The guides explain the steps taken to run the simulation…

Shellman, Stephen M.; Turan, Kursad

2006-01-01

373

THE CIRCUMFUSION SYSTEM FOR MULTIPURPOSE CULTURE CHAMBERS  

PubMed Central

A self-contained mechanical system for circulating nutrient fluid through 12 tissue culture chambers is described in detail. This system utilizes nonperforated cellophane membranes in the chambers which separate the circulating nutrient from the tissue culture environments. The nutrient, therefore, is dialyzed through the cellophane of each chamber; some cell products are retained in the microenvironment between the closely apposed cellophane and cover slip, whereas the other cell products move from chamber to chamber in the circulating nutrient. The resultant environmental conditions directed by the circumfusion systems are highly favorable for maintaining the differentiation of chick embryo tissues over protracted periods; a number of micrographs are shown.

Rose, George G.

1967-01-01

374

Multipurpose Active\\/Passive Motion Compensation System  

Microsoft Academic Search

A microprocessor-controlled active\\/passive motion compensation system has been developed for deploying a variety of geotechnical in-situ testing devices with mobile drilling rigs from low-cost service vessels. The light-weight rotary heave compensator incorporates a hydraulic motor as the compensator actuator and a servo-controlled closed loop pump to reduce the air storage and power requirements. Unique features of the system are the

R. A. Sullivan; M. Davenport; R. Clements

1984-01-01

375

Design and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl-bis-pivaloyloxymethyl (POM) prodrug form.  

PubMed

Reported herein are the synthesis and solid-phase peptide incorporation of N-Fmoc-(2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid bis-pivaloyloxymethyl phosphoryl ester [Fmoc-Pmab(POM)2-OH, 2] as a phosphatase-stable phosphothreonine (pThr) mimetic bearing orthogonal protection suitable for the synthesis of Pmab-containing peptides having bio-reversible protection of the phosphonic acid moiety. This represents the first report of a bio-reversibly protected pThr mimetic in a form suitable for facile solid-phase peptide synthesis. PMID:23907438

Qian, Wen-Jian; Burke, Terrence R

2013-08-02

376

{l_brace}XW{sub 12}O{sub 40} [Cu(en){sub 2}(H{sub 2}O)]{sub 3}{r_brace} (X=V, Si): Two novel tri-supported Keggin POMs with transition metal complexes  

SciTech Connect

Two novel polyoxometalate derivatives, {l_brace}X{sup IV}W{sup VI}{sub 10}W{sup V}{sub 2}O{sub 40}[Cu(en){sub 2}(H{sub 2}O)]{sub 3}{r_brace} [X=V (1), Si (2); en=ethylenediamine], have been hydrothermally synthesized and characterized by elemental analyses, IR, UV-Vis, XPS, EPR, TG and single crystal X-ray diffraction analyses. They represent the first classical Keggin polyoxoanion supported by three transition metal complex moieties, which further act as the neutral molecular unit for the construction of the interesting three-dimensional supramolecular frameworks. The magnetic properties of 1 have also been studied in the temperature range of 4-300 K, and its magnetic susceptibility obeys the Curie-Weiss law, showing antiferromagnetic coupling. - Graphical abstract: The first classical Keggin polyoxoanion tri-supported by TMC moieties via bridge oxygen atoms, {l_brace}X{sup IV}W{sup VI}{sub 10}W{sup V}{sub 2}O{sub 40}[Cu(en){sub 2}(H{sub 2}O)]{sub 3}{r_brace}, act as the neutral molecular unit to construct the interesting 3-D supramolecular frameworks.

Lu Yukun; Cui Xiaobing; Chen Yan; Xu Jianing; Zhang Qingbin; Liu Yabing [College of Chemistry and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, Jilin 130021 (China); Xu Jiqing, E-mail: xjq@mail.jlu.edu.c [College of Chemistry and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, Jilin 130021 (China); Wang Tiegang [College of Chemistry and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun, Jilin 130021 (China)

2009-08-15

377

Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)  

PubMed Central

Here, we examine the significance that stereochemistry plays within the clinically relevant Janus Kinase 3 (Jak3) inhibitor CP-690,550. A synthesis of all four enantiopure stereoisomers of the drug was carried out and an examination of each compound revealed that only the enantiopure 3R, 4R isomer was capable of blocking Stat5 phosphorylation (Jak3 dependent). Each compound was profiled across a panel of over 350 kinases which revealed a high level of selectivity for the Jak family kinases for these related compounds. Each stereoisomer retained a degree of binding to Jak3 and Jak2 and the 3R, 4S and 3S, 4R stereoisomers were further revealed to have binding affinity for selected members of the STE7 and STE20 subfamily of kinases. Finally, an appraisal of the minimum energy conformation of each stereoisomer and molecular docking at Jak3 was performed in an effort to better understand each compounds selectivity and potency profiles.

Jiang, Jian-kang; Ghoreschi, Kamran; Deflorian, Francesca; Chen, Zhi; Perreira, Melissa; Pesu, Marko; Smith, Jeremy; Nguyen, Dac-Trung; Liu, Eric H.; Leister, William; Costanzi, Stefano; O'Shea, John J.; Thomas, Craig J.

2009-01-01

378

Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550).  

PubMed

Here, we examine the significance that stereochemistry plays within the clinically relevant Janus kinase 3 (Jak3) inhibitor 1 (CP-690,550). A synthesis of all four enantiopure stereoisomers of the drug was carried out and an examination of each compound revealed that only the enantiopure 3R,4R isomer was capable of blocking Stat5 phosphorylation (Jak3 dependent). Each compound was profiled across a panel of over 350 kinases, which revealed a high level of selectivity for the Jak family kinases for these related compounds. Each stereoisomer retained a degree of binding to Jak3 and Jak2 and the 3R,4S and 3S,4R stereoisomers were further revealed to have binding affinity for selected members of the STE7 and STE20 subfamily of kinases. Finally, an appraisal of the minimum energy conformation of each stereoisomer and molecular docking at Jak3 was performed in an effort to better understand each compounds selectivity and potency profiles. PMID:19053756

Jiang, Jian-kang; Ghoreschi, Kamran; Deflorian, Francesca; Chen, Zhi; Perreira, Melissa; Pesu, Marko; Smith, Jeremy; Nguyen, Dac-Trung; Liu, Eric H; Leister, William; Costanzi, Stefano; O'Shea, John J; Thomas, Craig J

2008-12-25

379

Back to the 3 R's: Reading, Writing, Rhetoric.  

ERIC Educational Resources Information Center

Contemporary understandings and practices of adult literacy and adult basic education need to reestablish a substantial connection with ancient rhetoric as at once a political tradition, a culture of language use, a storehouse of metalanguage, and as an ensemble of pedagogic strategies and exercises. Developed in ancient Greece, rhetoric was for…

McCormack, Rob

380

(2S,3R,4S,4aR)-2,3,4,7-Tetra-hydroxy-3,4,4a,5-tetra-hydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one hemihydrate.  

PubMed

The title natural compound, isolated from Narcissus pseudonarcissus var. King Alfred crystallizes as a hemihydrate, C14H13NO7·0.5H2O, with four crystallographically independent dioxolophenanthridinone mol-ecules and two crystallographically independent solvent water mol-ecules in the asymmetric unit. All four crystallographically independent dioxolophenanthridinone mol-ecules are geometrically very similar and differ only in the orientations of the three hy-droxy groups at the terminal cyclo-hexene rings. The five-membered dioxolane ring has a planar conformation (the r.m.s. deviations are 0.010, 0.019, 0.025 and 0.004?Å, for the four crystallographically independent molecules), and the six-membered dihydro-pyridone and cyclo-hexene rings adopt sofa conformations in each mol-ecule. The flattened structure of each dioxolophenanthridinone mol-ecule is supported by a strong intra-molecular O-H?O hydrogen bond. The N atom has a slightly pyramidalized configuration. In the crystal, the dioxolophenanthridinone mol-ecules form layers parallel to (101) with O-H?O and N-H?O hydrogen bonds linking the dioxolophenanthridinone mol-ecules both within and between the layers and the water mol-ecules, forming a three-dimensional framework. The absolute configurations of the chiral centers are 2S, 3R, 4S and 4aR. PMID:23476470

Jucov, Evgheni; Kornienko, Alexander; Masi, Marco; Evidente, Antonio; Antipin, Mikhail

2012-12-05

381

A novel representative {l_brace}[Rb{sub 1.94}(H{sub 2}O,OH){sub 3.84}](H{sub 2}O){sub 0.1}{r_brace}{l_brace}Al{sub 4}(OH){sub 4}[PO{sub 4}]{sub 3}{r_brace} in the pharmacosiderite structure type  

SciTech Connect

The crystal structure of a new synthetic aluminophosphate {l_brace}[Rb{sub 1.94}(H{sub 2}O,OH){sub 3.84}](H{sub 2}O){sub 0.1}{r_brace}{l_brace}Al{sub 4}(OH){sub 4}[PO{sub 4}]{sub 3}{r_brace} synthesized under mild hydrothermal conditions (T = 280{sup o}C, P = 100 atm) in the Rb{sub 2}O-Al{sub 2}O{sub 3}-P{sub 2}O{sub 5}-H{sub 2}O system is determined using X-ray diffraction (Stoe IPDS diffractometer, {lambda}MoK{sub {alpha}}, graphite monochromator, 2{theta}{sub max} = 64.33{sup o}, R = 0.032 for 312 reflections). The main crystal data are as follows: a = 7.4931(6) A, space group P 4 bar 3m, Z = 1, and {rho}{sub calcd} = 2.76 g/cm{sup 3}. It is shown that the synthesized compound belongs to the pharmacosiderite structure type with a characteristic mixed open microporous framework composed of octahedra and tetrahedra. A comparative crystal chemical analysis of related phases is performed, and the chemical compositions of promising absorbents, i.e., hypothetical compounds potentially possible in the structure type under consideration, are proposed. It is established that pharmacosiderite and rhodizite are homeotypic to each other.

Yakubovich, O. V., E-mail: yakubol@geol.msu.ru [Lomonosov Moscow State University (Russian Federation); Massa, W. [Philipps-Universitaet Marburg (Germany); Dimitrova, O. V. [Lomonosov Moscow State University (Russian Federation)

2008-05-15

382

Spectroscopic studies (FTIR, FT-Raman and UV), potential energy surface scan, normal coordinate analysis and NBO analysis of (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl) piperidine-3,4,5-triol by DFT methods.  

PubMed

This work presents the characterization of (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol (abbreviated as HEHMPT) by quantum chemical calculations and spectral techniques. The spectroscopic properties were investigated by FT-IR, FT-Raman and UV-Vis techniques. The FT-IR spectrum (4000-400 cm(-1)) and FT-Raman spectrum (4000-100 cm(-1)) in solid phase was recorded for HEHMPT. The UV-Vis absorption spectrum of the HEHMPT that dissolved in water was recorded in the range of 100-400 nm. The structural and spectroscopic data of the molecule were obtained from B3LYP and M06-2X with 6-31G(d,p) basis set calculations. The theoretical wavenumbers were scaled and compared with experimental FT-IR and FT-Raman spectra. The complete assignments were performed on the basis of the normal co-ordinate analysis (NCA), experimental results and potential energy distribution (PED) of the vibrational modes, calculated with scaled quantum mechanics (SQM) method, interpreted in terms of fundamental modes. The stable geometry of the compound has been determined from the potential energy surface scan. The stability of molecule has been analyzed by NBO analysis. The molecule orbital contributions were studied by using the total (TDOS), partial (PDOS), and overlap population (OPDOS) density of states. The electronic properties like UV spectral analysis and HOMO-LUMO energies were reported. The calculated HOMO and LUMO energies shows that charge transfer interactions taking place within the molecule. Mulliken population analysis on atomic charges is also calculated. PMID:23454843

Isac Paulraj, E; Muthu, S

2013-02-06

383

Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist.  

PubMed

The in vitro and in vivo pharmacological properties of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl)carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103) are presented. A potent 5-hydroxytryptamine (5-HT)(2A) receptor inverse agonist ACP-103 competitively antagonized the binding of [(3)H]ketanserin to heterologously expressed human 5-HT(2A) receptors with a mean pK(i) of 9.3 in membranes and 9.70 in whole cells. ACP-103 displayed potent inverse agonist activity in the cell-based functional assay receptor selection and amplification technology (R-SAT), with a mean pIC(50) of 8.7. ACP-103 demonstrated lesser affinity (mean pK(i) of 8.80 in membranes and 8.00 in whole cells, as determined by radioligand binding) and potency as an inverse agonist (mean pIC(50) 7.1 in R-SAT) at human 5-HT(2C) receptors, and lacked affinity and functional activity at 5-HT(2B) receptors, dopamine D(2) receptors, and other human monoaminergic receptors. Behaviorally, ACP-103 attenuated head-twitch behavior (3 mg/kg p.o.), and prepulse inhibition deficits (1-10 mg/kg s.c.) induced by the 5-HT(2A) receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride in rats and reduced the hyperactivity induced in mice by the N-methyl-d-aspartate receptor noncompetitive antagonist 5H-dibenzo[a,d]cyclohepten-5,10-imine (dizocilpine maleate; MK-801) (0.1 and 0.3 mg/kg s.c.; 3 mg/kg p.o.), consistent with a 5-HT(2A) receptor mechanism of action in vivo and antipsychotic-like efficacy. ACP-103 demonstrated >42.6% oral bioavailability in rats. Thus, ACP-103 is a potent, efficacious, orally active 5-HT(2A) receptor inverse agonist with a behavioral pharmacological profile consistent with utility as an antipsychotic agent. PMID:16469866

Vanover, Kimberly E; Weiner, David M; Makhay, Malath; Veinbergs, Isaac; Gardell, Luis R; Lameh, Jelveh; Del Tredici, Andria L; Piu, Fabrice; Schiffer, Hans H; Ott, Thomas R; Burstein, Ethan S; Uldam, Allan K; Thygesen, Mikkel B; Schlienger, Nathalie; Andersson, Carl Magnus; Son, Thomas Y; Harvey, Scott C; Powell, Susan B; Geyer, Mark A; Tolf, Bo-Ragner; Brann, Mark R; Davis, Robert E

2006-02-09

384

Bronchodilator activity of (3R)-3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino] carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyclo[2.2.2]octane bromide (CHF5407), a potent, long-acting, and selective muscarinic M3 receptor antagonist.  

PubMed

The novel quaternary ammonium salt (3R)-3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino]carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyclo[2.2.2]octane bromide (CHF5407) showed subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2), and M3 (hM3) receptors and dissociated very slowly from hM3 receptors (t(½) = 166 min) with a large part of the receptorial complex (54%) remaining undissociated at 32 h from radioligand washout. In contrast, [(3)H]CHF5407 dissociated quickly from hM2 receptors (t(½) = 31 min), whereas [(3)H]tiotropium dissociated slowly from both hM3 (t(½) = 163 min) and hM2 receptor (t(½) = 297 min). In the guinea pig isolated trachea and human isolated bronchus, CHF5407 produced a potent (pIC(50) = 9.0-9.6) and long-lasting (up to 24 h) inhibition of M3 receptor-mediated contractile responses to carbachol. In the guinea pig electrically driven left atrium, the M2 receptor-mediated inhibitory response to carbachol was recovered more quickly in CHF5407-pretreated than in tiotropium-pretreated preparations. CHF5407, administered intratracheally to anesthetized guinea pigs, potently inhibited acetylcholine (Ach)-induced bronchoconstriction with an ED(50) value of 0.15 nmol/kg. The effect was sustained over a period of 24 h, with a residual 57% inhibition 48 h after antagonist administration at 1 nmol/kg. In conscious guinea pigs, inhaled CHF5407 inhibited Ach-induced bronchoconstriction for at least 24 h as did tiotropium at similar dosages. Cardiovascular parameters in anesthetized guinea pigs were not significantly changed by CHF5407, up to 100 nmol/kg i.v. and up to 1000 nmol/kg i.t. In conclusion, CHF5407 shows a prolonged antibronchospastic activity both in vitro and in vivo, caused by a very slow dissociation from M3 receptors. In contrast, CHF5407 is markedly short-acting at M2 receptors, a behavior not shared by tiotropium. PMID:20805306

Villetti, G; Pastore, F; Bergamaschi, M; Bassani, F; Bolzoni, P T; Battipaglia, L; Amari, G; Rizzi, A; Delcanale, M; Volta, R; Cenacchi, V; Cacciani, F; Zaniboni, M; Berti, F; Rossoni, G; Harrison, S; Petrillo, P; Santoro, E; Scudellaro, R; Mannini, F; Geppetti, P A; Razzetti, R; Patacchini, R; Civelli, M

2010-08-30

385

Overview of bacterial cellulose composites: A multipurpose advanced material.  

PubMed

Bacterial cellulose (BC) has received substantial interest owing to its unique structural features and impressive physico-mechanical properties. BC has a variety of applications in biomedical fields, including use as biomaterial for artificial skin, artificial blood vessels, vascular grafts, scaffolds for tissue engineering, and wound dressing. However, pristine BC lacks certain properties, which limits its applications in various fields; therefore, synthesis of BC composites has been conducted to address these limitations. A variety of BC composite synthetic strategies have been developed based on the nature and relevant applications of the combined materials. BC composites are primarily synthesized through in situ addition of reinforcement materials to BC synthetic media or the ex situ penetration of such materials into BC microfibrils. Polymer blending and solution mixing are less frequently used synthetic approaches. BC composites have been synthesized using numerous materials ranging from organic polymers to inorganic nanoparticles. In medical fields, these composites are used for tissue regeneration, healing of deep wounds, enzyme immobilization, and synthesis of medical devices that could replace cardiovascular and other connective tissues. Various electrical products, including biosensors, biocatalysts, E-papers, display devices, electrical instruments, and optoelectronic devices, are prepared from BC composites with conductive materials. In this review, we compiled various synthetic approaches for BC composite synthesis, classes of BC composites, and applications of BC composites. This study will increase interest in BC composites and the development of new ideas in this field. PMID:24053844

Shah, Nasrullah; Ul-Islam, Mazhar; Khattak, Waleed Ahmad; Park, Joong Kon

2013-08-15

386

Passive solar retro-fit, multipurpose community center  

SciTech Connect

An appropriate technology monitoring evaluation is given for a project to retrofit a solar greenhouse to a community center in Okalahoma. Progress on the construction is evaluated, and the management and bookkeeping for the project are very briefly described. Appended are correspondence and financial documents related to the project. (LEW)

Not Available

1981-04-23

387

Airborne information initiatives: capitalizing on a multipurpose broadcast communications architecture  

NASA Astrophysics Data System (ADS)

This paper describes an experimental broadcast data link system architecture to identify and validate requirements for a broadcast data link and associated applications. Three key broadcast applications, including: automatic dependent surveillance-broadcast, flight information services-broadcast, and traffic information service-broadcast, are being investigated. The experimental system comprises three prototype components. The components are the universal access transceiver, the airborne research prototype, and the ground broadcast server. Simplicity, affordability, and beneficial capabilities are the driving considerations for this work. The operational objectives are: to provide capabilities that are simple, affordable, and provide immediate benefit and utility to the aircraft operator; to enhance the user's ability to maintain separation from other aircraft; and to enable simplifications to the air traffic management process.

Strain, R. C.; Moody, J. C.; Hahn, E. C.; Dunbar, B. E.; Kavoussi, S.; Mittelman, J. P.

1996-05-01

388

Sterilization validation for medical compresses at IRASM multipurpose irradiation facility  

NASA Astrophysics Data System (ADS)

In Romania, IRASM Radiation Processing Center is the unique supplier of radiation sterilization services—industrial scale (ISO 9001:2000 and ISO 13485:2003 certified). Its Laboratory of Microbiological Testing is the sole third party competent laboratory (GLPractice License, ISO 17025 certification in progress) for pharmaceutics and medical devices as well. We here refer to medical compresses as a distinct category of sterile products, made from different kind of hydrophilic materials (cotton, non-woven, polyurethane foam) with or without an impregnated ointment base (paraffin, plant extracts). These products are included in the class of medical devices, but for the sterilization validation, from microbiological point of view, there are important differences in testing method compared to the common medical devices (syringes, catheters, etc). In this paper, we present some results and practical solutions chosen to perform a sterilization validation, compliant with ISO 11137: 2006.

Alexandru, Mioara; Ene, Mihaela

2007-08-01

389

Wireless capsule endoscopy: from diagnostic devices to multipurpose robotic systems  

Microsoft Academic Search

In the recent past, the introduction of miniaturised image sensors with low power consumption, based on complementary metal\\u000a oxide semiconductor (CMOS) technology, has allowed the realisation of an ingestible wireless capsule for the visualisation\\u000a of the small intestine mucosa. The device has received approval from Food and Drug Administration and has gained momentum\\u000a since it has been more successful than

Andrea Moglia; Arianna Menciassi; Marc Oliver Schurr; Paolo Dario

2007-01-01

390

Multipurpose 5-MeV linear induction accelerator  

SciTech Connect

Although linear induction accelerators (LIAs) are quite reliable by most standards, they are limited in repeating rate, average power, and reliability because the final stage of energy delivery is based on spark gap performance. In addition, they have a low duty factor of operation. To provide a higher burst rate and greater reliability, the researchers used new technology to develop a magnetic pulse compression scheme that eliminates all spark gaps and exceeds requirements. The paper describes the scheme. The magnetic drive system can be tailored to drive induction cells from a few kA to over 10 kA at 500 kV, with average beam power levels in the megawatts. This new 5-MeV, 2.5-kA LIA under construction at the Lawrence Livermore National Laboratory (LLNL) will be used for the development of high brightness sources and will provide a test bed for the new technology, which should lead to LIAs that surpass the radio frequency linacs for efficiency and reliability, as well as fit other industrial applications, such as sewage sterilization.

Birx, D.L.; Hawkins, S.A.; Poor, S.E.; Reginato, L.L. Smith, M.W.

1984-06-11

391

Molecular network topology and reliability for multipurpose diagnosis.  

PubMed

This investigation proposes the use of molecular network topology for drug delivery and diagnosis network design. Three modules of molecular network topologies, such as bus, star, and ring networks, are designed and manipulated based on a micro- and nanoring resonator system. The transportation of the trapping molecules by light in the network is described and the theoretical background is reviewed. The quality of the network is analyzed and calculated in terms of signal transmission (ie, signal to noise ratio and crosstalk effects). Results obtained show that a bus network has advantages over star and ring networks, where the use of mesh networks is possible. In application, a thin film network can be fabricated in the form of a waveguide and embedded in artificial bone, which can be connected to the required drug targets. The particular drug/nutrient can be transported to the required targets via the particular network used. PMID:22072875

Moongfangklang, N; Jalil, M A; Innate, K; Mitatha, S; Ali, J; Yupapin, P P

2011-10-19

392

Wireless capsule endoscopy: from diagnostic devices to multipurpose robotic systems.  

PubMed

In the recent past, the introduction of miniaturised image sensors with low power consumption, based on complementary metal oxide semiconductor (CMOS) technology, has allowed the realisation of an ingestible wireless capsule for the visualisation of the small intestine mucosa. The device has received approval from Food and Drug Administration and has gained momentum since it has been more successful than traditional techniques in the diagnosis of small intestine disorders. In 2004 an esophagus specific capsule was launched, while a solution for colon is still under development. However, present solutions suffer from several limitations: they move passively by exploiting peristalsis, are not able to stop intentionally for a prolonged diagnosis, they receive power from an internal battery with short length, and their usage is restricted to one organ, either small bowel or esophagus. However the steady progresses in many branches of engineering, including microelectromechanical systems (MEMS), are envisaged to affect the performances of capsular endoscopy. The near future foreshadows capsules able to pass actively through the whole gastrointestinal tract, to retrieve views from all organs and to perform drug delivery and tissue sampling. In the long term, the advent of robotics could lead to autonomous medical platforms, equipped with the most advanced solutions in terms of MEMS for therapy and diagnosis of the digestive tract. In this review, we discuss the state of the art of wireless capsule endoscopy (WCE): after a description on the current status, we present the most promising solutions. PMID:17160703

Moglia, Andrea; Menciassi, Arianna; Schurr, Marc Oliver; Dario, Paolo

2007-04-01

393

Dynamics and control of MTV: a multipurpose unmanned underwater vehicle  

Microsoft Academic Search

The Manta Test Vehicle (MTV) has been built by the US Navy as the prototype of a new class of unmanned underwater vehicles (UWs). The paper presents the complete nonlinear dynamics model of the MTV and discusses the design of its control system. As MTV's first in-water trial is still to come, performance is shown through simulated runs

Alberico Menozzi; T. C. Galiardi; Sergey E. Lyshevski

2000-01-01

394

ELECTROMAGNETIC PROPULSION SYSTEMS: MULTIPURPOSE PLATFORMS OF THE FUTURE  

Microsoft Academic Search

Substantial research has been conducted at universities and major defense laboratories regarding the design, development, and implementation of electromagnetic launching systems. Such devices are capable of almost instantaneously accelerating masses to extremely high velocities, and could be utilized as an alternative propulsion mechanism for future orbital satellite launching. Relying on the physics of the principle of electromagnetic induction, such devices

Jonathan Dumm; Kevin Murray

395

Illuminating RHIC matter with the multi-purpose direct photon  

NASA Astrophysics Data System (ADS)

In the RHIC era, the use of direct photon physics to probe heavy ion collisions has developed beyond its original scope. I make evaluations of the current state of several measurements by RHIC experiments and their associated physics implications, with a focus on their current and desired precision. At low pT, thermal photon theory is still not well constrained by the data, but improvements are on the way. At higher pT, we have been able to gain important insights, now with regards to the proposed 'jet-medium' photon sources (Fries, Muller and Srivastava 2003 Phys. Rev. Lett. 90 132301 (Preprint nucl-th/0208001); Zakharov 2004 JETP Lett. 80 617). Such predictions, as they currently exist, seem to be disfavoured by the PHENIX data; however, the idea is probably not ruled out. Finally, direct ?-jet correlations have been measured for the first time at RHIC and already show hints of medium modification.

Frantz, Justin

2007-08-01

396

Admission to university engineering programs in Sweden: a multipurpose approach.  

PubMed

This brief article provides a description of some new ideas about admission of university engineering students in Sweden. The current system of admission is based on upper-secondary school grades and the Swedish Scholastic Assessment Test. These measures are used for admission to all higher education. For many reasons, ideas for a new admission model have been proposed. This model includes a sector-oriented admission test, which the universities are supposed to use for different purposes, such as selection, eligibility, diagnostics, and recruitment. PMID:15362381

Wolming, Simon; Lyrén, Per-Erik

2004-06-01

397

LASERS: Multipurpose high-power electrogasdynamic CO laser  

NASA Astrophysics Data System (ADS)

A novel mobile self-contained ecologically acceptable cw high-power CO laser is proposed. This laser is intended for a variety of applications and is based on standard electrical machinery with a gas-turbine drive. The novelty lies in the formation of a laser mixture during the operation of the laser by combustion of a chemical fuel. The light-emitting CO molecules are excited by a natural discharge in a supersonic stream. The results are given of a feasibility test of a model prototype CO laser based on combustion products when the CO molecules were excited by an electric discharge. Possible technological applications of the proposed laser are considered. The likelihood of its extensive use in industry and in special tasks, which should lead to a high demand for the laser, are discussed.

Baranov, I. Ya

1994-06-01

398

Design and construction of a multipurpose wideband anechoic chamber  

Microsoft Academic Search

An electromagnetic anechoic chamber has been constructed at the Multimedia University. It is designed to operate over a very wide frequency range from 30 MHz through 18 GHz. It can be used for electromagnetic compatibility (EMC) tests, antenna measurements, radar cross section (RCS) measurements, testing RF transceivers, calibration of scatterometers, and other electromagnetic research experiments. The geometry of the chamber

B. K. Chung; H. T. Chuah

2003-01-01

399

A Novel Multipurpose Model Set for Teaching General Chemistry.  

ERIC Educational Resources Information Center

Reports on a low-cost and unique molecular model set capable of generating a large number of structures for teaching and learning general chemistry. An important component of the kit is an 11-hole ball that gives tetrahedral, octahedral, trigonal, trigonal bipyramidal, and square planar symmetries. (WRM)

Gupta, H. O.; Parkash, Brahm

1999-01-01

400

Model primary content type for multipurpose internet mail extensions  

SciTech Connect

The purpose of this memo is to propose an update to Internet RFC 2045 to include a new primary content-type to be known as `model`. RFC 2045 [1] describes mechanisms for specifying and describing the format of Internet Message Bodies via content-type/subtype pairs. We believe that `model` defines a fundamental type of content with unique presentational, hardware, and processing aspects. Various subtypes of this primary type are immediately anticipated but will be covered under separate documents.

Nelson, S.; Parks, C.

1997-01-01

401

Ephus: Multipurpose Data Acquisition Software for Neuroscience Experiments  

PubMed Central

Physiological measurements in neuroscience experiments often involve complex stimulus paradigms and multiple data channels. Ephus (http://www.ephus.org) is an open-source software package designed for general-purpose data acquisition and instrument control. Ephus operates as a collection of modular programs, including an ephys program for standard whole-cell recording with single or multiple electrodes in typical electrophysiological experiments, and a mapper program for synaptic circuit mapping experiments involving laser scanning photostimulation based on glutamate uncaging or channelrhodopsin-2 excitation. Custom user functions allow user-extensibility at multiple levels, including on-line analysis and closed-loop experiments, where experimental parameters can be changed based on recently acquired data, such as during in vivo behavioral experiments. Ephus is compatible with a variety of data acquisition and imaging hardware. This paper describes the main features and modules of Ephus and their use in representative experimental applications.

Suter, Benjamin A.; O'Connor, Timothy; Iyer, Vijay; Petreanu, Leopoldo T.; Hooks, Bryan M.; Kiritani, Taro; Svoboda, Karel; Shepherd, Gordon M. G.

2010-01-01

402

A multipurpose high-rate GPS observatory for northwestern Mexico  

NASA Astrophysics Data System (ADS)

We describe a proposed joint atmospheric and geophysical high-rate GPS observatory in northwestern Mexico complementing and extending analogous networks in the United Stated. The observatory would measure atmospheric water vapor during the North American Monsoon Experiment (NAME) as well as crustal velocities within and across the Gulf of California and the Mexican Basin and Range region for geodetic applications. The NOAA-sponsored NAME scheduled for several summers beginning in 2004 addresses the challenging issue of determining and improving the predictability of warm season precipitation in the mountainous region of the Northwestern Mexico and Southwestern US. Much of the rainfall in the region comes during the North American Monsoon each summer. Rainfall in the region is particularly difficult to model and predict because the orography and the complex land-sea geometry of the region with moisture sources in the Gulf of Mexico, Gulf of California and the eastern subtropical Pacific Ocean. The GPS provides accurate, near-continuous observations of water vapor in clear and cloudy air needed to sample the large diurnal variations in the dynamic and thermodynamic properties of the atmosphere. GPS in combination with wind and other measurements scattered in and around the region will provide much needed constraints to determine quantitatively the sources supplying moisture for precipitation within the NAME area. Tectonic applications of this continuous GPS network in Mexico include high-precision determinations of plate boundary deformation in and around the Gulf of California and possible diffuse deformation within the Mexican Basin and Range province. Because of the high sampling rate (1 Hz), the network will also provide data for seismological applications, including surface wave studies (e.g., Larson et al., SCIENCE, 2003) and potential near-field displacement records. Furthermore the network would complement the US-based Plate Boundary Observatory (PBO) facility by extending continuous GPS coverage into northern Mexico and other relatively smaller-scale continuous GPS networks in southern Mexico as well as provide important data for surveying and mapping applications. Several years of observations are required to capture the substantial year-to-year variations in the monsoon and yield accurate estimates of tectonic motion. Both objectives can be accomplished relatively inexpensively with the simple and robust GPS observations made in collaboration with investigators in Mexico.

Kursinski, E. R.; Bennett, R. A.; Hahmann, A.

2003-12-01

403

Microwave lamp with multi-purpose rotary motor  

DOEpatents

In a microwave powered electrodeless lamp, a single rotary motor is used to (a) rotate the bulb and (b) provide rotary motion to a blower or pump means for providing cooling fluid to the magnetron and/or to a forced gas cooler for providing cooling gas to the bulb. The blower may consist of only of an impeller without the usual blower housing. The motor, bulb stem and bulb, or motor, bulb stem, bulb and blower may be formed as an integral unit so as to facilitate replacement. 8 figs.

Ury, M.G.; Turner, B.; Wooten, R.D.

1999-02-02

404

Development Multi-Purpose Automatic Spraymarker System: Final Report.  

National Technical Information Service (NTIS)

Compared to marking on hot rolled coils or heavy plates the new productions area, such as continuous casting, have established the need for a new approach of marking. The use of an industrial robot, as a re-programmable manipulator, increased the flexibil...

J. C. Groothuizen

1986-01-01

405

MESS: Multi-purpose Exoplanet Simulation System (Bonavita+, 2012)  

NASA Astrophysics Data System (ADS)

All the IDL routines needed to run the MESS code are included, together with a script providing an example of its use, and all the necessary input files. Save all the file in the same directory, or add the directory where the .pro files are extracted to your IDL path. A step by step tutorial, further examples and newer versions of the code can be downloaded from www.messthecode.com Please send an email to info@messthecode.com for any suggestion/request. (2 data files).

Bonavita, M.; Chauvin, G.; Desidera, S.; Gratton, R.; Janson, M.; Beuzit, J. L.; Kasper, M.; Mordasini, C.

2011-11-01

406

Comparison of requirements and capabilities of major multipurpose software packages.  

PubMed

The aim of this chapter is to introduce the reader to commonly used software packages and illustrate their input requirements, analysis options, strengths, and limitations. We focus on packages that perform more than one function and include a program for quality control, linkage, and association analyses. Additional inclusion criteria were (1) programs that are free to academic users and (2) currently supported, maintained, and developed. Using those criteria, we chose to review three programs: Statistical Analysis for Genetic Epidemiology (S.A.G.E.), PLINK, and Merlin. We will describe the required input format and analysis options. We will not go into detail about every possible program in the packages, but we will give an overview of the packages requirements and capabilities. PMID:22307719

Igo, Robert P; Schnell, Audrey H

2012-01-01

407

Multipurpose Advanced 'inherently' Safe Reactor (MARS): Core design studies  

SciTech Connect

In the year 2005, in collaboration with CEA, the University of Rome 'La Sapienza' investigated a new core model with the aim at increasing the performances of the reference one, by extending the burn-up to 60 GWD/t in the case of multi-loading strategy and investigating the characteristics and limitations of a 'once-through' option, in order to enhance the proliferation resistance. In the first part of this paper, the objectives of this study and the methods of calculation are briefly described, while in the second part the calculation results are presented. (authors)

Golfier, H. [DM2S/SERMA/LCA, CEA Saclay, 91191 Gif-sur-Yvette Cedex (France); Caterino, S. [Univ. of Rome La Sapienza, Dept. of Nuclear Engineering and Energy Conversion, Corso Vittorio Emanuele II, 244 00186 Rome (Italy); Poinot, C.; Delpech, M.; Mignot, G. [DM2S/SERMA/LCA, CEA Saclay, 91191 Gif-sur-Yvette Cedex (France); Naviglio, A.; Gandini, A. [Univ. of Rome La Sapienza, Dept. of Nuclear Engineering and Energy Conversion, Corso Vittorio Emanuele II, 244 00186 Rome (Italy)

2006-07-01

408

Multi-heme proteins: nature's electronic multi-purpose tool.  

PubMed

While iron is often a limiting nutrient to Biology, when the element is found in the form of heme cofactors (iron protoporphyrin IX), living systems have excelled at modifying and tailoring the chemistry of the metal. In the context of proteins and enzymes, heme cofactors are increasingly found in stoichiometries greater than one, where a single protein macromolecule contains more than one heme unit. When paired or coupled together, these protein associated heme groups perform a wide variety of tasks, such as redox communication, long range electron transfer and storage of reducing/oxidizing equivalents. Here, we review recent advances in the field of multi-heme proteins, focusing on emergent properties of these complex redox proteins, and strategies found in Nature where such proteins appear to be modular and essential components of larger biochemical pathways. This article is part of a Special Issue entitled: Metals in Bioenergetics and Biomimetics Systems. PMID:23558243

Bewley, Kathryn D; Ellis, Katie E; Firer-Sherwood, Mackenzie A; Elliott, Sean J

2013-04-02

409

US EPA, Pesticide Product Label, MISTY MULTI-PURPOSE ...  

EPA Pesticide Factsheets

... j !\\V()I,j Irl'l,ll.l!lllfl pI ',pr,lY flll',\\ AI,'(lId ',klll (:O'l1.H t WARNING C onll' Ill" IIlldl" pr I'SS 1111' {)I' fl :)1 fi~ Illl t 111(' ( (111\\.1 1111'1 [lc) nlll "III!)' ,\\II'fnp('I,I\\I ...

2011-04-19

410

Molecular network topology and reliability for multipurpose diagnosis  

PubMed Central

This investigation proposes the use of molecular network topology for drug delivery and diagnosis network design. Three modules of molecular network topologies, such as bus, star, and ring networks, are designed and manipulated based on a micro- and nanoring resonator system. The transportation of the trapping molecules by light in the network is described and the theoretical background is reviewed. The quality of the network is analyzed and calculated in terms of signal transmission (ie, signal to noise ratio and crosstalk effects). Results obtained show that a bus network has advantages over star and ring networks, where the use of mesh networks is possible. In application, a thin film network can be fabricated in the form of a waveguide and embedded in artificial bone, which can be connected to the required drug targets. The particular drug/nutrient can be transported to the required targets via the particular network used.

Jalil, MA; Moongfangklang, N; Innate, K; Mitatha, S; Ali, J; Yupapin, PP

2011-01-01

411

Multi-Purpose Reefs - A Decade of Application  

NASA Astrophysics Data System (ADS)

Offshore submerged structures for coastal protection and artificial reefs for enhancing local marine biodiversity and/or attracting sea life have been utilized for centuries. Indeed, the first known use of artificial reef structures for habitat enhancement dates back to 2000 BC on the south west coast of India. However, it was not until the 1960's that multi- purpose reefs (MPRs) intended combine coastal protection, eco-enhancement and surfing were first proposed. Through the 1970's and 1980's the concept of MPR's was advanced through the seminal works of James 'Kimo' Walker who pioneered the area of surfing science and developed the first methods for quantification of a surfing break. Design studies for artificial reefs primarily for surfing were undertaken for the construction of the world's first artificial surfing reef built in Perth in 1998, as well as for artificial reefs in California and the Queensland Gold Coast MPR in Australia. More than a decade on, seven reefs have now been constructed at locations around the world with differing levels of success. and a great deal has been learned about the functionality of and potential applications for these structures. This poster provides a brief update on the performance of these structures, summarizing the large volume of monitoring data available for many of these projects. This includes data on shoreline protection and beach response, ecological enhancement, habitat restoration and improvement of recreational amenities. We discuss several projects with respect to the above topics as well as some of the lessons learned in the light of future MPR developments. This poster considers the performance of MPR's in three primary areas of functionality: coastal protection, ecological enhancement and surfing enhancement. We also discuss some of the lessons learned and applied as understanding of these structures has increased.

Mead, S.; Borrero, J. C.; Hearin, J.

2011-12-01

412

Outline of multipurpose utilization of geothermal resources in China  

SciTech Connect

China is rich in geothermal resources. The lower temperature limit of geothermal waters in China is defined as 25/sup 0/C. The thermal waters are categorized into three groups: low (25/sup 0/ to 60/sup 0/C), medium (60/sup 0/ to 100/sup 0/C) and high (> 100/sup 0/C) temperature thermal water. Xizang (Tibet), Taiwan and Yunnan are the most promising regions for the development of high temperature geothermal energy. Medium-low temperature water is more efficient for direct use. Since 1977, six experimental geothermal power stations have been set up throughout the country. In Beijing (Peking), Tianjin and other places thermal water has been used for space heating, industrial processing, agriculture, horticulture, and therapeutic sanatoriums, etc.

Huang, S.Y.; Wang, J.Y.; Wang, J.; Huang, G.S.

1980-09-01

413

In vitro micropropagation of Gymnema sylvestre – A multipurpose medicinal plant  

Microsoft Academic Search

The nature of the explant, seedling age, medium type, plant growth regulators, complex extracts (casein hydrolysate, coconut\\u000a milk, malt extract and yeast extract) and antioxidants (activated charcoal, ascorbic acid, citric acid and polyvinylpyrrolidone)\\u000a markedly influenced in vitro propagation of Gymnema sylvestre. A maximum number of shoots (57.2) were induced from 30 day old seedling axillary node explants on Murashige and

N. Komalavalli; M. V. Rao

2000-01-01

414

Algorithms star in multipurpose systems (real-time operating systems)  

SciTech Connect

Important aspects of real-time operating systems are examined. These aspects include the multitasking schedules and queues; interrupt handling; protocols, intertask communication and monitors; and methods of reducing overheads. The discussion is illustrated with mentions of actual systems. 1 ref.

Not Available

1983-03-24

415

Microwave lamp with multi-purpose rotary motor  

DOEpatents

In a microwave powered electrodeless lamp, a single rotary motor is used to a) rotate the bulb and b) provide rotary motion to a blower or pump means for providing cooling fluid to the magnetron and/or to a forced gas cooling for providing cooler gas to the bulb. The blower may consist of only of an impeller without the usual blower housing. The motor, bulb stem and bulb, or motor, bulb stem, bulb and blower may be formed as an integral unit so as to facilitate replacement.

Ury, Michael G. (Bethesda, MD); Turner, Brian (Myersville, MD); Wooten, Robert D. (Rockville, MD)

1999-01-01

416

Radial glia: multi-purpose cells for vertebrate brain development  

Microsoft Academic Search

Radial glia are specialized cells in the developing nervous system of all vertebrates, and are characterized by long radial processes. These processes facilitate the best known function of radial glia: guiding the radial migration of newborn neurons from the ventricular zone to the mantle regions. Recent data indicate further important roles for these cells as ubiquitous precursors that generate neurons

Kenneth Campbell; Magdalena Götz

2002-01-01

417

[Portable multi-purpose device for monitoring of physiological informations].  

PubMed

Unconstrained system that measures physiological information as skin temperatures and heart rate per unit time of a human subject was developed. The system contained portable device included memory control unit, instrumentation unit, timer and batteries, read-out unit, test unit and verify unit. Total number of data and channels, and interval were selected by switches in the memory control unit. The data from the instrumentation unit were transferred to memory control unit and stored in the Erasable Programmable ROM (EPROM). After measurement, EPROM chip was taken off the memory control unit and put on the read-out unit which transferred the data to the microcomputer. The data were directly calculated and analyzed by microcomputer. In application of the instrumentation unit, 8-channel skin thermometer was developed and tested. After amplification, 8 analog signals were multiplexed and converted into the binary codes. The digital signals were sequentially transferred to memory control unit and stored in the EPROM under controlled signal. The accuracy of the system is determined primarily by the accuracy of the sensor of instrumentation unit. The overall accuracy of 8-channel skin thermometer is conservatively stated within 0.1 degree C. This may prove to be useful in providing an objective measurement of human subjects, and can be used in studying environmental effect for human body and sport activities in a large population setting. PMID:6655595

Tamura, T; Togawa, T

1983-05-01

418

Low-cost multipurpose coatings from alkyd-ketonic blends  

Microsoft Academic Search

Reports a comprehensive study of the effects of blend ratios (aliphatic alkyd and cyclohexanone formaldehyde resins) on coating properties. Solvent and drier systems used for preparation of blends are also included in the present work. The properties studied were hardness, adhesion, flexibility, gloss, storage stability, impact resistance, chemical resistance and drying time. A blend ratio of 50:50 (w\\/w) aliphatic alkyd-ketonic

V. D. Athawale; A. V. Chamankar

2000-01-01

419

Multipurpose explosive (MPX) drum-shaped packaging design criteria.  

National Technical Information Service (NTIS)

In fiscal year 1993, the Transportation Management Division of the US Department of Energy sponsored an engineering study, completed by Westinghouse Hanford Company, to examine the viability of a generic packaging design able to satisfy multiple explosive...

1994-01-01

420

A Study of a Proposed Multi-Purpose Communications System.  

ERIC Educational Resources Information Center

|A faculty committee, consisting of members from various departments and from the Audiovisual Center at Washington State University (WSU), investigated the feasibility of establishing a two-way television network in the southeastern Washington area for participants in continuing education studies and for certain graduate classes. The committee…

Washington State Univ., Pullman.

421

Enhanced Lethality Multi-Purpose Tank Munition for FCS.  

National Technical Information Service (NTIS)

Responding to the materiel needs of the U.S. soldier is a challenge requiring engineers and scientists to bridge capability gaps by developing systems that counter or prevent the threats of our enemies. The Armament Research, Development, and Engineering ...

E. Scheper J. Sunderland M. Hall S. Gilman

2006-01-01

422

Multipurpose 2000 C furnace for physical testing in controlled atmosphere  

NASA Astrophysics Data System (ADS)

A high temperature (2000 C) furnace and a servohydraulic test frame were purchased and installed for physical testing in controlled atmospheres of structural ceramics made superplastic by advanced ceramic processing.

Chen, I.-Wei

1990-02-01

423

Sterilization validation for medical compresses at IRASM multipurpose irradiation facility  

Microsoft Academic Search

In Romania, IRASM Radiation Processing Center is the unique supplier of radiation sterilization services—industrial scale (ISO 9001:2000 and ISO 13485:2003 certified). Its Laboratory of Microbiological Testing is the sole third party competent laboratory (GLPractice License, ISO 17025 certification in progress) for pharmaceutics and medical devices as well.We here refer to medical compresses as a distinct category of sterile products, made

Mioara Alexandru; Mihaela Ene

2007-01-01

424

Dynamic versus static allocation policies in multipurpose multireservoir systems  

Microsoft Academic Search

As the competition for water is likely to increase in the near future due to socioeconomic development and population growth, water resources managers will face hard choices when allocating water between competing users. Because water is a vital resource used in multiple sectors, including the environment, the allocation is inherently a political and social process, which is likely to become

A. Tilmant; Q. Goor; D. Pinte; P. van der Zaag

2007-01-01

425

National RF Test Facility as a multipurpose development tool  

SciTech Connect

Additions and modifications to the National RF Test Facility design have been made that (1) focus its use for technology development for future large systems in the ion cyclotron range of frequencies (ICRF), (2) expand its applicability to technology development in the electron cyclotron range of frequencies (ECRF) at 60 GHz, (3) provide a facility for ELMO Bumpy Torus (EBT) 60-GHz ring physics studies, and (4) permit engineering studies of steady-state plasma systems, including superconducting magnet performance, vacuum vessel heat flux removal, and microwave protection. The facility will continue to function as a test bed for generic technology developments for ICRF and the lower hybrid range of frequencies (LHRF). The upgraded facility is also suitable for mirror halo physics experiments.

McManamy, T.J.; Becraft, W.R.; Berry, L.A.; Blue, C.W.; Gardner, W.L.; Haselton, H.H.; Hoffman, D.J.; Loring, C.M. Jr.; Moeller, F.A.; Ponte, N.S.

1983-01-01

426

On the scheduling of a multipurpose laboratory analysis instrument  

Microsoft Academic Search

Automated laboratory analysis by the time-resolved fluoroimmuno technique is a modern application of biochemistry and embedded computer technology. The laboratory system is interesting from the point of view of scheduling. The laboratory system, AutoDELFIA, consists of 14 modules which can work partially in parallel: pumper, loader, x-lane, reagent lane, elevator, washer, remover, enhancement dispenser, reagent dispenser, barcode reader, incubator, measurement

K. Palletvuori; O. Nevalainen; P. Luostarinen; K. Muurinen

1997-01-01

427

A multipurpose high-rate GPS observatory for northwestern Mexico  

Microsoft Academic Search

We describe a proposed joint atmospheric and geophysical high-rate GPS observatory in northwestern Mexico complementing and extending analogous networks in the United Stated. The observatory would measure atmospheric water vapor during the North American Monsoon Experiment (NAME) as well as crustal velocities within and across the Gulf of California and the Mexican Basin and Range region for geodetic applications. The

E. R. Kursinski; R. A. Bennett; A. Hahmann

2003-01-01

428

Adaptive Educational Gameplay within Smart Multipurpose Interactive Learning Environment  

Microsoft Academic Search

Modern technologies have brought many innovations into the system of education. Learners now have an opportunity to educate with the help of electronic materials often provided by web-based infrastructures. Although the majority of learners - especially children or teenagers - find studying from such materials less exciting than playing today's popular computer games that, however, lack signs of education. In

Marko Divéky; P. Jurnecka; R. Kajan; E. Omelina; M. Bielikova

2007-01-01

429

Priming by NUMB3R5 Does Not Involve Top-Down Feedback  

ERIC Educational Resources Information Center

|Using the same-different task, Perea, Dunabeitia, Pollatsek, and Carreiras (2009) showed that digits resembling letters ("leet digits"; e.g., 1 = "I", 4 = "A") primed pseudoword strings (e.g., "V35Z3D-VESZED"), but letters resembling digits ("leet letters") did not prime digit strings (e.g., "9ES7E2-935732"), and suggested that this is due to…

Kinoshita, Sachiko; Lagoutaris, Stephanie

2010-01-01

430

NCI Funded Research Portfolio - 3R01CA090360-05S1 Detail  

Cancer.gov

Skip to content Your source for National Cancer Institute funded research grants, contract awards, and intramural research projects. More Home Advanced Search Funding Statistics About NFRP Contact Us Related Links Help Viewing Project « Back to results

431

NCI Funded Research Portfolio - 3R01CA136495-03S1 Detail  

Cancer.gov

Skip to content Your source for National Cancer Institute funded research grants, contract awards, and intramural research projects. More Home Advanced Search Funding Statistics About NFRP Contact Us Related Links Help Viewing Project « Back to results

432

NCI Funded Research Portfolio - 3R01CA112215-04S2 Detail  

Cancer.gov

PROVIDED. Precise tumor diagnosis and classification is the first step in cancer management. While many tumor biopsies are diagnostic and form the cornerstone of cancer therapy, classification of tumor type and site of origin, is an ever-present clinical challenge. It is estimated that up to 10% of all tumors have no defined primary site of origin and that thousands of dollars are spent per case to identify the site of origin with limited overall success.

433

NCI Funded Research Portfolio - 3R01CA121110-05S1 Detail  

Cancer.gov

Skip to content Your source for National Cancer Institute funded research grants, contract awards, and intramural research projects. More Home Advanced Search Funding Statistics About NFRP Contact Us Related Links Help Viewing Project « Back to results

434

Kähler quantization of H3(CY3,R) and the holomorphic anomaly  

Microsoft Academic Search

Studying the quadratic field theory on seven dimensional spacetime constructed by a direct product of Calabi-Yau three-fold by a real time axis, with phase space being the third cohomology of the Calabi-Yau three-fold, the generators of translation along moduli directions of Calabi-Yau three-fold are constructed. The algebra of these generators is derived which take a simple form in canonical coordinates.

Farhang Loran

2005-01-01

435

UTILITY ADVANCED TURBINE SYSTEMS (ATS) TECHNOLOGY READINESS TESTING PHASE 3 RESTRUCTURED (3R)  

SciTech Connect

Much of the ''H'' technology design is based on proven, established technologies. The major technologies of the combined cycle powertrain, including the bearing designs, the evaluation methods for rotor dynamics, the compressor and turbine blading designs, and the generator field construction methods are all either direct applications of proven design technology or evolutionary refinement of existing designs. It is for these reasons that GE expects that the reliability of the new ''H'' Class generating system will be fully commensurate with the levels associated with today's ''F'' Class combined cycle power plants. With maintenance and operations performed at ''best practice'' levels, the new ''H'' Class plant should reach its full reliability potential of 97.0% or better.

Unknown

2000-09-01

436

NCI Funded Research Portfolio - 3R33CA120726-03S1 Detail  

Cancer.gov

Skip to content Your source for National Cancer Institute funded research grants, contract awards, and intramural research projects. More Home Advanced Search Funding Statistics About NFRP Contact Us Related Links Help Viewing Project « Back to results

437

NCI Funded Research Portfolio - 3R33CA120726-02S1 Detail  

Cancer.gov

Skip to content Your source for National Cancer Institute funded research grants, contract awards, and intramural research projects. More Home Advanced Search Funding Statistics About NFRP Contact Us Related Links Help Viewing Project « Back to results

438

NCI Funded Research Portfolio - 3R01CA125244-03S1 Detail  

Cancer.gov

Skip to content Your source for National Cancer Institute funded research grants, contract awards, and intramural research projects. More Home Advanced Search Funding Statistics About NFRP Contact Us Related Links Help Viewing Project « Back to results

439

NCI Funded Research Portfolio - 3R01CA086257-07S1 Detail  

Cancer.gov

Skip to content Your source for National Cancer Institute funded research grants, contract awards, and intramural research projects. More Home Advanced Search Funding Statistics About NFRP Contact Us Related Links Help Viewing Project « Back to results

440

NCI Funded Research Portfolio - 3R01CA140326-03S2 Detail  

Cancer.gov

Skip to content Your source for National Cancer Institute funded research grants, contract awards, and intramural research projects. More Home Advanced Search Funding Statistics About NFRP Contact Us Related Links Help Viewing Project « Back to results