Science.gov

Sample records for 5-4 xrq2 form

  1. Form factor dispersion at La M5,4 edges and average density of resonant atoms.

    PubMed

    Smadici, S; Lee, J C T; Logvenov, G; Bozovic, I; Abbamonte, P

    2014-01-15

    Resonant soft x-ray scattering on complex oxide superlattices shows very large variations in the superlattice reflection position and intensity near La M5,4 edges. Resonant dispersion of the La x-ray form factor describes the observations well. We determine the average density of resonant La atoms and the thickness of superlattice layers. PMID:24318961

  2. The solubility of the tetragonal form of hen egg white lysozyme from pH 4.0 to 5.4

    NASA Technical Reports Server (NTRS)

    Cacioppo, Elizabeth; Pusey, Marc L.

    1991-01-01

    Hen egg white lysozyme solubilities in the presence of the tetragonal crystal form have been determined. Conditions investigated cover the pH range 4.0 to 5.4, varying from 2.0 to 7.0 percent NaCl concentrations and from 4 to 25 C. In all instances, the solubilities were found to increase with temperature and decrease with increasing salt concentration. The effects of pH were more complex, showing a decreasing solubility with increasing pH at low salt concentration and an increasing solubility with increasing pH at high salt concentration.

  3. 4 CFR 5.4 - Pay administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 4 Accounts 1 2013-01-01 2013-01-01 false Pay administration. 5.4 Section 5.4 Accounts GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL SYSTEM COMPENSATION § 5.4 Pay administration. The provisions of chapter 55 of title 5, U.S. Code and the Office of Personnel Management implementing regulations apply to...

  4. 4 CFR 5.4 - Pay administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 4 Accounts 1 2014-01-01 2013-01-01 true Pay administration. 5.4 Section 5.4 Accounts GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL SYSTEM COMPENSATION § 5.4 Pay administration. The provisions of chapter 55 of title 5, U.S. Code and the Office of Personnel Management implementing regulations apply to...

  5. 4 CFR 5.4 - Pay administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 4 Accounts 1 2010-01-01 2010-01-01 false Pay administration. 5.4 Section 5.4 Accounts GOVERNMENT ACCOUNTABILITY OFFICE PERSONNEL SYSTEM COMPENSATION § 5.4 Pay administration. The provisions of chapter 55 of title 5, U.S. Code and the Office of Personnel Management implementing regulations apply to...

  6. 43 CFR 1610.5-4 - Maintenance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Maintenance. 1610.5-4 Section 1610.5-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR GENERAL MANAGEMENT (1000) PLANNING, PROGRAMMING, BUDGETING Resource...

  7. The 5-(4-Ethynylophenoxy) isophthalic chloride

    NASA Technical Reports Server (NTRS)

    Hergenrother, P. M.; Jensen, B. J. (Inventor)

    1986-01-01

    Sulfone-ester polymers containing pendent ethynyl groups and a direct and multistep process for preparing them are disclosed. The multistep process involves the conversion of a pendent bromo group to the ethynyl group while the direct route involves reating hydroxy-terminated sulfone oligomer or polymers with a stoichiometric amount of 5-(4-ethynylphenoxy) isophthaloyl chloride. The 5-(4-ethynylphenoxy) isophthaloyl chloride and the process for preparing it are also disclosed.

  8. 12 CFR 5.4 - Filing required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CORPORATE ACTIVITIES Rules of General Applicability § 5.4 Filing required. (a) Filing. A depository institution shall file an application or notice with the OCC to engage in corporate activities and... advise an applicant through a pre-filing communication to send the filing or submission directly to...

  9. 43 CFR 2650.5-4 - Village surveys.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Village surveys. 2650.5-4 Section 2650.5-4...: Generally § 2650.5-4 Village surveys. (a) Only the exterior boundaries of contiguous entitlements for each village corporation will be surveyed. Where land within the outer perimeter of a selection is not...

  10. 43 CFR 2650.5-4 - Village surveys.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Village surveys. 2650.5-4 Section 2650.5-4...: Generally § 2650.5-4 Village surveys. (a) Only the exterior boundaries of contiguous entitlements for each village corporation will be surveyed. Where land within the outer perimeter of a selection is not...

  11. 43 CFR 2650.5-4 - Village surveys.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Village surveys. 2650.5-4 Section 2650.5-4...: Generally § 2650.5-4 Village surveys. (a) Only the exterior boundaries of contiguous entitlements for each village corporation will be surveyed. Where land within the outer perimeter of a selection is not...

  12. 43 CFR 2650.5-4 - Village surveys.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Village surveys. 2650.5-4 Section 2650.5-4...: Generally § 2650.5-4 Village surveys. (a) Only the exterior boundaries of contiguous entitlements for each village corporation will be surveyed. Where land within the outer perimeter of a selection is not...

  13. 29 CFR 5.3-5.4 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false 5.3-5.4 Section 5.3-5.4 Labor Office of the Secretary of Labor LABOR STANDARDS PROVISIONS APPLICABLE TO CONTRACTS COVERING FEDERALLY FINANCED AND ASSISTED... WORK HOURS AND SAFETY STANDARDS ACT) Davis-Bacon and Related Acts Provisions and Procedures §§ 5.3-5.4...

  14. 5 CFR 5.4 - Information and testimony.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Information and testimony. 5.4 Section 5.4 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES REGULATIONS, INVESTIGATION, AND ENFORCEMENT (RULE V) § 5.4 Information and testimony. When required by the Office, the...

  15. 5 CFR 5.4 - Information and testimony.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Information and testimony. 5.4 Section 5.4 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES REGULATIONS, INVESTIGATION, AND ENFORCEMENT (RULE V) § 5.4 Information and testimony. When required by the Office, the...

  16. 29 CFR 5.3-5.4 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false 5.3-5.4 Section 5.3-5.4 Labor Office of the Secretary of Labor LABOR STANDARDS PROVISIONS APPLICABLE TO CONTRACTS COVERING FEDERALLY FINANCED AND ASSISTED... WORK HOURS AND SAFETY STANDARDS ACT) Davis-Bacon and Related Acts Provisions and Procedures §§ 5.3-5.4...

  17. 29 CFR 5.3-5.4 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false 5.3-5.4 Section 5.3-5.4 Labor Office of the Secretary of Labor LABOR STANDARDS PROVISIONS APPLICABLE TO CONTRACTS COVERING FEDERALLY FINANCED AND ASSISTED... WORK HOURS AND SAFETY STANDARDS ACT) Davis-Bacon and Related Acts Provisions and Procedures §§ 5.3-5.4...

  18. 5 CFR 5.4 - Information and testimony.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Information and testimony. 5.4 Section 5.4 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES REGULATIONS, INVESTIGATION, AND ENFORCEMENT (RULE V) § 5.4 Information and testimony. When required by the Office, the...

  19. 5 CFR 5.4 - Information and testimony.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Information and testimony. 5.4 Section 5.4 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES REGULATIONS, INVESTIGATION, AND ENFORCEMENT (RULE V) § 5.4 Information and testimony. When required by the Office, the...

  20. 5 CFR 5.4 - Information and testimony.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Information and testimony. 5.4 Section 5.4 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE RULES REGULATIONS, INVESTIGATION, AND ENFORCEMENT (RULE V) § 5.4 Information and testimony. When required by the Office, the...

  1. 1 CFR 5.4 - Publication not authorized.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 1 General Provisions 1 2011-01-01 2011-01-01 false Publication not authorized. 5.4 Section 5.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.4 Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to...

  2. 1 CFR 5.4 - Publication not authorized.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 1 General Provisions 1 2013-01-01 2012-01-01 true Publication not authorized. 5.4 Section 5.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.4 Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to...

  3. 1 CFR 5.4 - Publication not authorized.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 1 General Provisions 1 2014-01-01 2012-01-01 true Publication not authorized. 5.4 Section 5.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.4 Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to...

  4. 1 CFR 5.4 - Publication not authorized.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 1 General Provisions 1 2012-01-01 2012-01-01 false Publication not authorized. 5.4 Section 5.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.4 Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to...

  5. 1 CFR 5.4 - Publication not authorized.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Publication not authorized. 5.4 Section 5.4 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER THE FEDERAL REGISTER GENERAL § 5.4 Publication not authorized. (a) Chapter 15 of title 44, United States Code, does not apply to...

  6. Planar pentacoordinate carbons in CBe5(4-) derivatives.

    PubMed

    Grande-Aztatzi, Rafael; Cabellos, José Luis; Islas, Rafael; Infante, Ivan; Mercero, José M; Restrepo, Albeiro; Merino, Gabriel

    2015-02-14

    The potential energy surfaces of a series of clusters with formula CBe5Lin(n-4) (n = 1 to 5) have been systematically explored. Our computations show that the lithium cations preserve the CBe5(4-) pentagon, such that the global minimum structure for these series of clusters has a planar pentacoordinate carbon (ppC) atom. The systems are primarily connected via a network of multicenter σ-bonds, in which the C atom acts as σ-acceptor and this acceptance of charge is balanced by the donation of the 2pz electrons to the π-cloud. The induced magnetic field analysis suggests that the clusters with formula CBe5Lin(n-4) (n = 1 to 5) are fully delocalized. The fact that these ppC-containing clusters are the lowest-energy forms on the corresponding potential energy surfaces raises expectations that these species can be prepared experimentally in the gas phase. PMID:25585940

  7. 27 CFR 5.4 - Delegations of the Administrator.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the Administrator's Authorities in 27 CFR Part 5, Labeling and Advertising of Distilled Spirits. You... Administrator. 5.4 Section 5.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... the Administrator. Most of the regulatory authorities of the Administrator contained in this part...

  8. 27 CFR 5.4 - Delegations of the Administrator.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... the Administrator's Authorities in 27 CFR Part 5, Labeling and Advertising of Distilled Spirits. You... Administrator. 5.4 Section 5.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... the Administrator. Most of the regulatory authorities of the Administrator contained in this part...

  9. 27 CFR 5.4 - Delegations of the Administrator.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... the Administrator's Authorities in 27 CFR Part 5, Labeling and Advertising of Distilled Spirits. You... Administrator. 5.4 Section 5.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... the Administrator. Most of the regulatory authorities of the Administrator contained in this part...

  10. 43 CFR 3585.5-4 - Notice of exploration.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Notice of exploration. 3585.5-4 Section 3585.5-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS White...

  11. 43 CFR 3110.5-4 - Accreted lands.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Accreted lands. 3110.5-4 Section 3110.5-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) NONCOMPETITIVE LEASES Noncompetitive Leases §...

  12. 43 CFR 3110.5-4 - Accreted lands.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Accreted lands. 3110.5-4 Section 3110.5-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) NONCOMPETITIVE LEASES Noncompetitive Leases §...

  13. 43 CFR 3110.5-4 - Accreted lands.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Accreted lands. 3110.5-4 Section 3110.5-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) NONCOMPETITIVE LEASES Noncompetitive Leases §...

  14. 11 CFR 5.4 - Availability of records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Availability of records. 5.4 Section 5.4... Availability of records. (a) In accordance with 2 U.S.C. 438(a), the Commission shall make the following... records subject to the Act and the maximum availability of such records to the public, nothing...

  15. 27 CFR 5.4 - Delegations of the Administrator.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the Administrator's Authorities in 27 CFR Part 5, Labeling and Advertising of Distilled Spirits. You... Administrator. 5.4 Section 5.4 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... the Administrator. Most of the regulatory authorities of the Administrator contained in this part...

  16. 43 CFR 3585.5-4 - Notice of exploration.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Notice of exploration. 3585.5-4 Section 3585.5-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS White...

  17. 41 CFR 51-5.4 - Purchase exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Purchase exceptions. 51-5.4 Section 51-5.4 Public Contracts and Property Management Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 5-CONTRACTING...

  18. 43 CFR 3585.5-4 - Notice of exploration.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Notice of exploration. 3585.5-4 Section 3585.5-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) SPECIAL LEASING AREAS White...

  19. SOHO Captures CME From X5.4 Solar Flare

    NASA Video Gallery

    The Solar Heliospheric Observatory (SOHO) captured this movie of the sun's coronal mass ejection (CME) associated with an X5.4 solar flare on the evening of March 6, 2012. The extremely fast and en...

  20. 5.4 Magnetic Resonance Imaging, Diagnostic Ultrasound

    NASA Astrophysics Data System (ADS)

    Bernhardt, J. H.

    This document is part of Subvolume A 'Fundamentals and Data in Radiobiology, Radiation Biophysics, Dosimetry and Medical Radiological Protection' of Volume 7 'Medical Radiological Physics' of Landolt-Börnstein - Group VIII 'Advanced Materials and Technologies'. It contains the Section '5.4 Magnetic Resonance Imaging, Diagnostic Ultrasound' of the Chapter '5 Medical Radiological Protection' with the contents:

  1. 43 CFR 3141.5-4 - Lease size.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Leasing in Special Tar Sand Areas § 3141.5-4 Lease size. Combined hydrocarbon leases or tar sand leases in Special Tar Sand Areas shall not exceed 5,760 acres....

  2. 43 CFR 3141.5-4 - Lease size.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Leasing in Special Tar Sand Areas § 3141.5-4 Lease size. Combined hydrocarbon leases or tar sand leases in Special Tar Sand Areas shall not exceed 5,760 acres....

  3. 43 CFR 3141.5-4 - Lease size.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Leasing in Special Tar Sand Areas § 3141.5-4 Lease size. Combined hydrocarbon leases or tar sand leases in Special Tar Sand Areas shall not exceed 5,760 acres....

  4. 43 CFR 3141.5-4 - Lease size.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Leasing in Special Tar Sand Areas § 3141.5-4 Lease size. Combined hydrocarbon leases or tar sand leases in Special Tar Sand Areas shall not exceed 5,760 acres....

  5. Completion Report for Well Cluster ER-5-4

    SciTech Connect

    U.S. Department of Energy, National Nuclear Security Administration, Nevada Site Office; Bechtel Nevada

    2005-02-01

    Well Cluster ER-5-4 was drilled for the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office, in support of the Nevada Environmental Restoration Project at the Nevada Test Site, Nye County, Nevada. The cluster consists of two wells, positioned about 30 meters apart on the same drill pad, constructed as part of a hydrogeologic investigation program for Frenchman Flat at the Nevada Test Site. Detailed lithologic descriptions with preliminary stratigraphic assignments for the well cluster are included in this report. These are based on composite drill cuttings collected every 3 meters, and 156 sidewall samples taken at various depths below 192 meters in both boreholes, supplemented by geophysical log data. Detailed petrographic, chemical, and mineralogical studies of rock samples were conducted on 122 samples. Well ER-5-4 penetrated approximately 1,120 meters of Quaternary and Tertiary alluvium before reaching total depth in Tertiary volcanic rocks at 1,137.5 meters. The deeper Well ER-5-4 No.2 penetrated 1,120.4 meters of alluvial sediments, and was terminated within Tertiary volcanic rocks at a depth of 2,133.6 meters, indicating that Paleozoic rocks are deeper than expected at this site.

  6. 37 CFR 5.4 - Petition for rescission of secrecy order.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... secrecy order. 5.4 Section 5.4 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK... APPLICATIONS IN FOREIGN COUNTRIES Secrecy Orders § 5.4 Petition for rescission of secrecy order. (a) A petition for rescission or removal of a secrecy order may be filed by, or on behalf of, any principal...

  7. 37 CFR 5.4 - Petition for rescission of secrecy order.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... secrecy order. 5.4 Section 5.4 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK... APPLICATIONS IN FOREIGN COUNTRIES Secrecy Orders § 5.4 Petition for rescission of secrecy order. (a) A petition for rescission or removal of a secrecy order may be filed by, or on behalf of, any principal...

  8. 37 CFR 5.4 - Petition for rescission of secrecy order.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... secrecy order. 5.4 Section 5.4 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK... APPLICATIONS IN FOREIGN COUNTRIES Secrecy Orders § 5.4 Petition for rescission of secrecy order. (a) A petition for rescission or removal of a secrecy order may be filed by, or on behalf of, any principal...

  9. 37 CFR 5.4 - Petition for rescission of secrecy order.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... secrecy order. 5.4 Section 5.4 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK... APPLICATIONS IN FOREIGN COUNTRIES Secrecy Orders § 5.4 Petition for rescission of secrecy order. (a) A petition for rescission or removal of a secrecy order may be filed by, or on behalf of, any principal...

  10. 43 CFR 2091.5-4 - Segregative effect and opening: Water power withdrawals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Segregative effect and opening: Water power withdrawals. 2091.5-4 Section 2091.5-4 Public Lands: Interior Regulations Relating to Public Lands... LAWS AND RULES Segregation and Opening of Lands § 2091.5-4 Segregative effect and opening: Water...

  11. 43 CFR 2091.5-4 - Segregative effect and opening: Water power withdrawals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Segregative effect and opening: Water power withdrawals. 2091.5-4 Section 2091.5-4 Public Lands: Interior Regulations Relating to Public Lands... LAWS AND RULES Segregation and Opening of Lands § 2091.5-4 Segregative effect and opening: Water...

  12. 43 CFR 2091.5-4 - Segregative effect and opening: Water power withdrawals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Segregative effect and opening: Water power withdrawals. 2091.5-4 Section 2091.5-4 Public Lands: Interior Regulations Relating to Public Lands... LAWS AND RULES Segregation and Opening of Lands § 2091.5-4 Segregative effect and opening: Water...

  13. 7 CFR 5.4 - Commodities for which parity prices shall be calculated.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Commodities for which parity prices shall be calculated. 5.4 Section 5.4 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.4 Commodities for which parity prices shall be calculated. Parity prices shall be calculated for the following commodities: Basic...

  14. 7 CFR 5.4 - Commodities for which parity prices shall be calculated.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Commodities for which parity prices shall be calculated. 5.4 Section 5.4 Agriculture Office of the Secretary of Agriculture DETERMINATION OF PARITY PRICES § 5.4 Commodities for which parity prices shall be calculated. Parity prices shall be calculated for the following commodities: Basic...

  15. 36 CFR 5.4 - Commercial passenger-carrying motor vehicles.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... motor vehicles. 5.4 Section 5.4 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR COMMERCIAL AND PRIVATE OPERATIONS § 5.4 Commercial passenger-carrying motor vehicles. (a) The commercial transportation of passengers by motor vehicles except as authorized under a contract...

  16. 18 CFR 5.4 - Acceleration of a license expiration date.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... license expiration date. 5.4 Section 5.4 Conservation of Power and Water Resources FEDERAL ENERGY... APPLICATION PROCESS § 5.4 Acceleration of a license expiration date. (a) Request for acceleration. (1) No... chapter, a written request for acceleration of the expiration date of its existing license, containing...

  17. 18 CFR 5.4 - Acceleration of a license expiration date.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... license expiration date. 5.4 Section 5.4 Conservation of Power and Water Resources FEDERAL ENERGY... APPLICATION PROCESS § 5.4 Acceleration of a license expiration date. (a) Request for acceleration. (1) No... chapter, a written request for acceleration of the expiration date of its existing license, containing...

  18. 18 CFR 5.4 - Acceleration of a license expiration date.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... license expiration date. 5.4 Section 5.4 Conservation of Power and Water Resources FEDERAL ENERGY... APPLICATION PROCESS § 5.4 Acceleration of a license expiration date. (a) Request for acceleration. (1) No... chapter, a written request for acceleration of the expiration date of its existing license, containing...

  19. 18 CFR 5.4 - Acceleration of a license expiration date.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... license expiration date. 5.4 Section 5.4 Conservation of Power and Water Resources FEDERAL ENERGY... APPLICATION PROCESS § 5.4 Acceleration of a license expiration date. (a) Request for acceleration. (1) No... chapter, a written request for acceleration of the expiration date of its existing license, containing...

  20. 18 CFR 5.4 - Acceleration of a license expiration date.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Acceleration of a license expiration date. 5.4 Section 5.4 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT INTEGRATED LICENSE APPLICATION PROCESS § 5.4 Acceleration of a...

  1. Outcomes of the 5-4-3-2-1 Go Childhood Obesity Community Trial

    ERIC Educational Resources Information Center

    Evans, W. Douglas; Christoffel, Katherine K.; Necheles, Jonathan; Becker, Adam B.; Snider, Jeremy

    2011-01-01

    Objectives: To determine effects of the "5-4-3-2-1 Go" community social marketing campaign on obesity risk factors. Methods: We randomly assigned 524 parents of 3- to 7-year-old children to receive "5-4-3-2-1 Go" counseling or not. We surveyed parents about "5-4-3-2-1 Go!" behaviors and perceptions of children's behaviors at baseline and one year…

  2. 37 CFR 5.4 - Petition for rescission of secrecy order.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Petition for rescission of secrecy order. 5.4 Section 5.4 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE, DEPARTMENT OF COMMERCE GENERAL SECRECY OF CERTAIN INVENTIONS AND LICENSES TO EXPORT AND FILE APPLICATIONS IN FOREIGN COUNTRIES Secrecy...

  3. 43 CFR 2091.5-4 - Segregative effect and opening: Water power withdrawals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Segregative effect and opening: Water power withdrawals. 2091.5-4 Section 2091.5-4 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SPECIAL LAWS AND RULES Segregation and Opening...

  4. 45 CFR 5.4 - Relationship between the FOIA and the Privacy Act of 1974.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ADMINISTRATION FREEDOM OF INFORMATION REGULATIONS Basic Policy § 5.4 Relationship between the FOIA and the... your request under the Privacy Act and part 5b. If there is any record that we need not release to...

  5. Combination of searches for anomalous top quark couplings with 5.4 fb(-1) of p(p)over-bar collisions

    SciTech Connect

    Abazov V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Alverson, G.; Aoki, M.; Askew, A.; Atkins, S.; Augsten, K.; Avila, C.; Badaud, F.; Bagby, L.; Baldin, B.; Bandurin, D. V.; Banerjee, S.; Barberis, E.; Baringer, P.; Barreto, J.; Bartlett, J. F.; Bassler, U.; Bazterra, V.; Bean, A.; Begalli, M.; Bellantoni, L.; Beri, S. B.; Bernardi, G.; Bernhard, R.; Bertram, I.; Besancon, M.; Beuselinck, R.; Bezzubov, V. A.; Bhat, P. C.; Bhatia, S.; Bhatnagar, V.; Blazey, G.; Blessing, S.; Bloom, K.; Boehnlein, A.; Boline, D.; Boos, E. E.; Borissov, G.; Bose, T.; Brandt, A.; Brandt, O.; Brock, R.; Brooijmans, G.; Bross, A.; Brown, D.; Brown, J.; Bu, X. B.; Buehler, M.; Buescher, V.; Bunichev, V.; Burdin, S.; Buszello, C. P.; Camacho-Perez, E.; Casey, B. C. K.; Castilla-Valdez, H.; Caughron, S.; Chakrabarti, S.; Chakraborty, D.; Chan, K. M.; Chandra, A.; Chapon, E.; Chen, G.; Chevalier-Thery, S.; Cho, D. K.; Cho, S. W.; Choi, S.; Choudhary, B.; Cihangir, S.; Claes, D.; Clutter, J.; Cooke, M.; Cooper, W. E.; Corcoran, M.; Couderc, F.; Cousinou, M. -C.; Croc, A.; Cutts, D.; Das, A.; Davies, G.; de Jong, S. J.; De La Cruz-Burelo, E.; Deliot, F.; Demina, R.; Denisov, D.; Denisov, S. P.; Desai, S.; Deterre, C.; DeVaughan, K.; Diehl, H. T.; Diesburg, M.; Ding, P. F.; Dominguez, A.; Dubey, A.; Dudko, L. V.; Duggan, D.; Duperrin, A.; Dutt, S.; Dyshkant, A.; Eads, M.; Edmunds, D.; Ellison, J.; Elvira, V. D.; Enari, Y.; Evans, H.; Evdokimov, A.; Evdokimov, V. N.; Facini, G.; Feng, L.; Ferbel, T.; Fiedler, F.; Filthaut, F.; Fisher, W.; Fisk, H. E.; Fortner, M.; Fox, H.; Fuess, S.; Garcia-Bellido, A.; Garcia-Gonzalez, J. A.; Garcia-Guerra, G. A.; Gavrilov, V.; Gay, P.; Geng, W.; Gerbaudo, D.; Gerber, C. E.; Gershtein, Y.; Ginther, G.; Golovanov, G.; Goussiou, A.; Grannis, P. D.; Greder, S.; Greenlee, H.; Grenier, G.; Gris, Ph; Grivaz, J-F; Grohsjean, A.; Gruenendahl, S.; Gruenewald, M. W.; Guillemin, T.; Gutierrez, G.; Gutierrez, P.; Haas, A.; Hagopian, S.; Haley, J.; Han, L.; Harder, K.; Harel, A.; Hauptman, J. M.; Hays, J.; Head, T.; Hebbeker, T.; Hedin, D.; Hegab, H.; Heinson, A. P.; Heintz, U.; Hensel, C.; Heredia-De La Cruz, I.; Herner, K.; Hesketh, G.; Hildreth, M. D.; Hirosky, R.; Hoang, T.; Hobbs, J. D.; Hoeneisen, B.; Hohlfeld, M.; Howley, I.; Hubacek, Z.; Hynek, V.; Lashvili, I.; Ilchenko, Y.; Illingworth, R.; Ito, A. S.; Jabeen, S.; Jaffe, M.; Jayasinghe, A.; Jesik, R.; Johns, K.; Johnson, E.; Johnson, M.; Jonckheere, A.; Jonsson, P.; Joshi, J.; Jung, A. W.; Juste, A.; Kaadze, K.; Kajfasz, E.; Karmanov, D.; Kasper, P. A.; Katsanos, I.; Kehoe, R.; Kermiche, S.; Khalatyan, N.; Khanov, A.; Kharchilava, A.; Kharzheev, Y. N.; Kiselevich, I.; Kohli, J. M.; Kozelov, A. V.; Kraus, J.; Kulikov, S.; Kumar, A.; Kupco, A.; Kurca, T.; Kuzmin, V. A.; Lammers, S.; Landsberg, G.; Lebrun, P.; Lee, H. S.; Lee, S. W.; Lee, W. M.; Lellouch, J.; Li, H.; Li, L.; Li, Q. Z.; Lim, J. K.; Lincoln, D.; Linnemann, J.; Lipaev, V. V.; Lipton, R.; Liu, H.; Liu, Y.; Lobodenko, A.; Lokajicek, M.; de Sa, R. Lopes; Lubatti, H. J.; Luna-Garcia, R.; Lyon, A. L.; Maciel, A. K. A.; Madar, R.; Magana-Villalba, R.; Malik, S.; Malyshev, V. L.; Maravin, Y.; Martinez-Ortega, J.; McCarthy, R.; McGivern, C. L.; Meijer, M. M.; Melnitchouk, A.; Menezes, D.; Mercadante, P. G.; Merkin, M.; Meyer, A.; Meyer, J.; et al.

    2012-07-09

    We present measurements of the tWb coupling form factors using information from electroweak single top quark production and from the helicity of W bosons from top quark decays in t{bar t} events. We set upper limits on anomalous tWb coupling form factors using data collected with the D0 detector at the Tevatron p{bar p} collider corresponding to an integrated luminosity of 5.4 fb{sup -1}.

  6. Distribution of Ground Motions for the 2008 Mw5.4 Chino Hills Earthquake

    NASA Astrophysics Data System (ADS)

    Yong, A.; Hough, S. E.; Wills, C. J.; Wald, D. J.

    2008-12-01

    The 29 July 2008 Mw5.4 Chino Hills earthquake was widely felt throughout the greater Los Angeles region. Over 40,000 people filled out the Community Internet Intensity Map (CIIM), also known as the "Did You Feel It?" questionnaire, and the ShakeMap for the event is constrained by amplitudes from over 500 stations. The CIIM responses provide Modified Mercalli Intensity (MMI) values for 802 Zip codes. Due to the dense population of the greater Los Angeles region, intensity values averaged within Zip codes provide good spatial correlation to the location of the actual reporting sites. We use a least-squares approach to fit the average MMI to a standard functional form, MMI = A - Br - C log r (where r represents distance from the observation site to the epicenter and A, B and C are constants), and calculate the residuals. The distribution of average intensities clusters closely around the curve of the equation, corroborating the conclusion (e.g., Atkinson and Wald, SRL, 2006) that CIIM intensities provide a consistent measure of earthquake ground motions. A comparison of CIIM intensities and instrumentally determined ShakeMap intensities reveals generally good correspondence, but suggests a tendency for ShakeMap intensities to be higher at basin sites. We conclude that the ShakeMap intensities reflect long-period amplification, whereas observed intensities were more controlled by higher frequency accelerations. Where both the CIIM map and ShakeMap show systematic variations, the distributions show a strong correlation with near-surface geological structure, as well as with basin depth. Our preliminary conclusions are: 1) as expected, intensities are lower at hard rock sites; 2) intensities are systematically higher in the deepest parts of the basin and significantly lower in shallow regions. Intensities are systematically lower to the west of the Newport-Inglewood fault correlating with subtle topographic relief and shallower basin depths; 3) there is a suggestion that

  7. Barium aluminides Ba{sub x}Al{sub 5}(x=3,3.5,4)

    SciTech Connect

    Jehle, Michael; Scherer, Harald; Wendorff, Marco; Roehr, Caroline

    2009-05-15

    Three aluminides of the series Ba{sub x}Al{sub 5}(x=3,3.5,4) were synthesized from stoichiometric ratios of the elements in Ta crucibles. The crystal structure of the new compound Ba{sub 7}Al{sub 10} was determined using single crystal X-ray data (space group R3-barm, a=604.23(9), c=4879.0(12)pm, Z=3, R1=0.0325). The compound exhibits Al Kagome (3.6.3.6.) nets in which half of the triangles form the basis of trigonal bipyramids Al{sub 5}. The apical Al are thus three-bonded assuming a charge of -2 ({sup 27}Al-NMR chemical shift delta=660pm), whereas the Al atoms of the basal triangle (i.e. of the Kagome net) are four-bonded and thus of formal charge -1(delta=490ppm). The total charge of the anion is thus exactly compensated by the Ba cations, i.e. the compound can be interpreted as an electron precise Zintl phase, exhibiting a distinct pseudo-band gap at the Fermi level of the calculated tDOS. According to the total formula, the structure displays a combination the stacking sequences of Ba{sub 3}Al{sub 5} and Ba{sub 4}Al{sub 5}, the structures of which have been redetermined with current methods (both hexagonal with space group P6{sub 3}/mmc; Ba{sub 3}Al{sub 5}: a=606.55(7), c=1461.8(2)pm, Z=2, R1=0.0239; Ba{sub 4}Al{sub 5}: a=609.21(7), c=1775.8(3)pm, Z=2, R1=0.0300). These three compounds with slightly different electron counts but similar polyanions allow to compare the bond lengths, the electronic structures and the overall bonding situation in dependence of positive or negative deviation of the electron count in relation to the novel formally electron precise Zintl compound Ba{sub 7}Al{sub 10}. - Al{sub 5} layers of Kagome nets in the new binary electron precise Zintl compound Ba{sub 3.5}Al{sub 5}, also found in Ba{sub 3}Al{sub 5} and Ba{sub 4}Al{sub 5}.

  8. 43 CFR 5.4 - When is a permit required for news-gathering activities?

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 1 2014-10-01 2014-10-01 false When is a permit required for news... Wildlife Service § 5.4 When is a permit required for news-gathering activities? (a) Permit requirements. News-gathering activities involving filming, videography, or still photography do not require a...

  9. 43 CFR 5.4 - When is a permit required for news-gathering activities?

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 1 2013-10-01 2013-10-01 false When is a permit required for news... Wildlife Service § 5.4 When is a permit required for news-gathering activities? (a) Permit requirements. News-gathering activities involving filming, videography, or still photography do not require a...

  10. 45 CFR 5.4 - Relationship between the FOIA and the Privacy Act of 1974.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 1 2014-10-01 2014-10-01 false Relationship between the FOIA and the Privacy Act... ADMINISTRATION FREEDOM OF INFORMATION REGULATIONS Basic Policy § 5.4 Relationship between the FOIA and the Privacy Act of 1974. (a) Coverage. The FOIA and this rule apply to all HHS records. The Privacy Act, 5...

  11. 45 CFR 5.4 - Relationship between the FOIA and the Privacy Act of 1974.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Relationship between the FOIA and the Privacy Act... ADMINISTRATION FREEDOM OF INFORMATION REGULATIONS Basic Policy § 5.4 Relationship between the FOIA and the Privacy Act of 1974. (a) Coverage. The FOIA and this rule apply to all HHS records. The Privacy Act, 5...

  12. 45 CFR 5.4 - Relationship between the FOIA and the Privacy Act of 1974.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false Relationship between the FOIA and the Privacy Act... ADMINISTRATION FREEDOM OF INFORMATION REGULATIONS Basic Policy § 5.4 Relationship between the FOIA and the Privacy Act of 1974. (a) Coverage. The FOIA and this rule apply to all HHS records. The Privacy Act, 5...

  13. 45 CFR 5.4 - Relationship between the FOIA and the Privacy Act of 1974.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 1 2011-10-01 2011-10-01 false Relationship between the FOIA and the Privacy Act... ADMINISTRATION FREEDOM OF INFORMATION REGULATIONS Basic Policy § 5.4 Relationship between the FOIA and the Privacy Act of 1974. (a) Coverage. The FOIA and this rule apply to all HHS records. The Privacy Act, 5...

  14. Thermoregulation in unrestrained rats during and after exposure to 1.5-4 G

    NASA Technical Reports Server (NTRS)

    Giacchino, J.; Horwitz, B. A.; Horowitz, J. M.

    1979-01-01

    Unrestrained rats were exposed to cold for 1 h during and immediately after exposure to hypergravic fields (1.5-4 G) to determine if they recover their ability to thermoregulate on reentry to 1-G conditions. In contrast to the decreased body temperatures observed when cold exposure occurred concurrently with acceleration, hypothalamic, carotid, and brown fat temperatures did not fall when rats were exposed to cold immediately after return to 1 G. These results support the hypothesis that the thermoregulatory alterations seen under hypergravic conditions are manifestations of an effect of ongoing exposure to hypergravity and can be reversed on termination of acceleration. The reversibility of the thermoregulatory impairment is apparently unaffected by the magnitude of the acceleration field over a range of 1.5-4 G.

  15. SPECTROSCOPIC EVIDENCE FOR A 5.4 MINUTE ORBITAL PERIOD IN HM CANCRI

    SciTech Connect

    Roelofs, Gijs H. A.; Rau, Arne; Marsh, Tom R.; Steeghs, Danny; Groot, Paul J.; Nelemans, Gijs E-mail: arau@mpe.mpg.de

    2010-03-10

    HM Cancri is a candidate ultracompact binary white dwarf with an apparent orbital period of only 5.4 minutes, as suggested by X-ray and optical light-curve modulations on that period, and by the absence of longer-period variability. In this Letter, we present Keck-I spectroscopy which shows clear modulation of the helium emission lines in both radial velocity and amplitude on the 5.4 minute period and no other. The data strongly suggest that the binary is emitting He I 4471 from the irradiated face of the cooler, less massive star, and He II 4686 from a ring around the more massive star. From their relative radial velocities, we measure a mass ratio q = 0.50 {+-} 0.13. We conclude that the observed 5.4 minute period almost certainly represents the orbital period of an interacting binary white dwarf. We thus confirm that HM Cnc is the shortest period binary star known: a unique test for stellar evolution theory, and one of the strongest known sources of gravitational waves for LISA.

  16. Design, synthesis and evaluation of isoxazolo[5,4-d]pyrimidin-4(5H)-one derivatives as antithrombotic agents.

    PubMed

    Yang, Jiabin; Su, Guoqiang; Ren, Yu; Chen, Yang

    2015-02-01

    A series of isoxazolo[5,4-d]pyrimidin-4(5H)-one derivatives have been designed and synthesized as novel antithrombotic agents. The 4-acetoxyl substituted derivative (6g) displays very strong FXa inhibitory activity (IC50=0.013μM), excellent anticoagulant effect in human plasma (2×PT=2.12μM) and high selectivity to thrombin and trypsin. Docking investigation of 6g with FXa protein revealed that the pyrimidone ring of 6g formed a π-π interaction with the phenyl ring of Tyr99, and the carbonyl group in the P1 moiety formed multiple hydrogen bonds to Ser214 and Trp215. These results showed that isoxazolo[5,4-d]pyrimidin-4(5H)-one is an attractive scaffold for designing novel factor Xa inhibitors and 4-carbonyl substituted phenyl ring could be used as novel S1 binding element. PMID:25559742

  17. Probing the Gaseous Disk of T Tau N with CN 5-4 Lines

    NASA Technical Reports Server (NTRS)

    Podio, L.; Kamp, I.; Codella, C.; Nisini, B.; Aresu, G.; Brittain, S.; Cabrit, S.; Dougados, C.; Grady, C.; Meijerink, R.; Sandell, G.; Spaans, M.; Thi, W.-F.; White, G. J.; Woitke, P.

    2014-01-01

    We present spectrally resolved observations of the young multiple system T Tau in atomic and molecular lines obtained with the Heterodyne Instrument for the Far Infrared on board Herschel. While CO, H2O, [C ii], and SO lines trace the envelope and the outflowing gas up to velocities of 33 km s(exp -1) with respect to systemic, the CN 5-4 hyperfine structure lines at 566.7, 566.9 GHz show a narrow double-peaked profile centered at systemic velocity, consistent with an origin in the outer region of the compact disk of T Tau N. Disk modeling of the T Tau N disk with the thermo-chemical code ProDiMo produces CN line fluxes and profiles consistent with the observed ones and constrain the size of the gaseous disk (R(sub out) = 110(+10/-20) AU) and its inclination (i = 25 deg +/- 5 deg). The model indicates that the CN lines originate in a disk upper layer at 40-110 AU from the star, which is irradiated by the stellar UV field and heated up to temperatures of 50-700 K. With respect to previously observed CN 2-1 millimeter lines, the CN 5-4 lines appear to be less affected by envelope emission, due to their larger critical density and excitation temperature. Hence, high-J CN lines are a unique confusion-free tracer of embedded disks, such as the disk of T Tau N.

  18. User s Guide for REFoffSpec Version 1.5.4

    SciTech Connect

    Ward, Richard C; Bilheux, Jean-Christophe; Lauter, Valeria; Ambaye, Haile Arena

    2012-09-01

    This document is a user s guide for the IDL software REFoffSpec version 1.5.4 whose purpose is to aggregate for analysis NeXus data files from the magnetism and liquids reflectometer experiments at the Oak Ridge National Laboratory Spallation Neutron Source. The software is used to scale and align multiple data files that constitute a continuous set for an experimental run. The User s Guide for REFoffSepc explains step by step the process using a specific example run. Output screens are provided to orient the user at each step. The guide documents in detail changes made to the original REFoffSpec code during the period November 2009 and January 2011. At the time of the completion of this version of the code it was accessible from the sns_tools interface as a beta version.

  19. PROBING THE GASEOUS DISK OF T Tau N WITH CN 5-4 LINES

    SciTech Connect

    Podio, L.; Codella, C.; Kamp, I.; Meijerink, R.; Spaans, M.; Nisini, B.; Aresu, G.; Brittain, S.; Cabrit, S.; Dougados, C.; Thi, W.-F.; Sandell, G.; White, G. J.; Woitke, P.

    2014-03-10

    We present spectrally resolved observations of the young multiple system T Tau in atomic and molecular lines obtained with the Heterodyne Instrument for the Far Infrared on board Herschel. While CO, H{sub 2}O, [C II], and SO lines trace the envelope and the outflowing gas up to velocities of 33 km s{sup –1} with respect to systemic, the CN 5-4 hyperfine structure lines at 566.7, 566.9 GHz show a narrow double-peaked profile centered at systemic velocity, consistent with an origin in the outer region of the compact disk of T Tau N. Disk modeling of the T Tau N disk with the thermo-chemical code ProDiMo produces CN line fluxes and profiles consistent with the observed ones and constrain the size of the gaseous disk (R{sub out}=110{sub −20}{sup +10} AU) and its inclination (i = 25°± 5°). The model indicates that the CN lines originate in a disk upper layer at 40-110 AU from the star, which is irradiated by the stellar UV field and heated up to temperatures of 50-700 K. With respect to previously observed CN 2-1 millimeter lines, the CN 5-4 lines appear to be less affected by envelope emission, due to their larger critical density and excitation temperature. Hence, high-J CN lines are a unique confusion-free tracer of embedded disks, such as the disk of T Tau N.

  20. A 5.4 MDOT OLED microdisplay for digital night vision and image fusion

    NASA Astrophysics Data System (ADS)

    Haas, Gunther; Espuno, Laurent; Marcellin-Dibon, Eric; Prat, Christophe; Gohri, Vipul

    2012-06-01

    We developed a 0.61'' diagonal OLED microdisplay dedicated to electronic viewfinders for digital vision systems, e.g. for security or other professional applications. The microdisplay has a very high resolution of 5.4 million subpixels and combines excellent image quality with low power consumption and a 10bit per color digital input. Subpixel pitch is 4.7x4.7μm². Thanks to the versatile architecture of the underlying ASIC circuit, the device can be easily adapted to different applications and image formats: In the standard full color version, the resulting resolution is 1300 by 1044 pixels (SXGA). In a monochrome version, the resolution is 2600 by 2088 independent pixels, enabling e.g. digital night vision at full 2K by 2K resolution. In addition to this, we developed two- and three color versions of the display that allow to merge high resolution monochrome images e.g.in 2K by 2K resolution with lower resolution images e.g., from an infrared sensor for image fusion or for adding colored graphical overlays.

  1. Resolution of 5.4 nm from a Photoemission Electron Microscope Corrected with an Electrostatic Mirror

    NASA Astrophysics Data System (ADS)

    Word, R. C.; Rempfer, G. F.; Almaraz, L.; Dixon, T.; Konenkamp, R.

    2010-03-01

    We report resolution of 5.4 +/- 0.5 nm for a photoemission electron microscope (PEEM) that employs an electrostatic mirror that simultaneously corrects chromatic and spherical aberration. This is a marked improvement over the 8 to 10nm resolution obtained by uncorrected PEEMs, which suffer particularly from chromatic aberration resulting from the acceleration of low energy photoelectrons from the specimen surface. The resolution was obtained in a biological application using sarcoplasmic reticulum from skeletal muscle as a specimen. The sample was deposited on a low photoemission substrate of chromium-coated glass and illuminated with UV light from a 100-mW 244-nm Ar laser. Resolution was determined using the 0.1 to 0.9 contrast change in intensity line profiles as well as by a 2-dimensional Fast Fourier Transform method. The PEEM employs a Y-branched beam separator, three deflection magnets, and twelve electrostatic lenses all heavily filtered to suppress voltage instabilities. Spherical and chromatic aberration coefficients were determined by computer modeling and in-situ experiments to be 1 cm. Once the instrument is perfected, the resolution should be 2 nm.

  2. Electron collisions with Fe-peak elements: Forbidden transitions between the low lying valence states 3d{sup 6}, 3d{sup 5}4s, and 3d{sup 5}4p of Fe III

    SciTech Connect

    McLaughlin, B.M. . E-mail: b.mclaughlin@qub.ac.uk; Scott, M.P.; Sunderland, A.G.; Noble, C.J.; Burke, V.M.; Ramsbottom, C.A.; Reid, R.H.G.; Hibbert, A.; Bell, K.L.; Burke, P.G.

    2007-01-15

    Effective collision strengths are presented for the Fe-peak element Fe III at electron temperatures (T {sub e} in degrees Kelvin) in the range 2 x 10{sup 3} to 1 x 10{sup 6}. Forbidden transitions results are given between the 3d{sup 6}, 3d{sup 5}4s, and the 3d{sup 5}4p manifolds applicable to the modeling of laboratory and astrophysical plasmas.

  3. THE NATURE OF EXTREMELY RED H - [4.5] > 4 GALAXIES REVEALED WITH SEDS AND CANDELS

    SciTech Connect

    Caputi, K. I.; Dunlop, J. S.; McLure, R. J.; Cirasuolo, M.; Huang, J.-S.; Fazio, G. G.; Ashby, M. L. N.; Castellano, M.; Fontana, A.; Almaini, O.; Bell, E. F.; Dickinson, M.; Donley, J. L.; Ferguson, H. C.; Grogin, N. A.; Koekemoer, A. M.; Faber, S. M.; Kocevski, D. D.; Koo, D. C.; and others

    2012-05-01

    We have analyzed a sample of 25 extremely red H - [4.5] > 4 galaxies, selected using 4.5 {mu}m data from the Spitzer SEDS survey and deep H-band data from the Hubble Space Telescope CANDELS survey, over {approx}180 arcmin{sup 2} of the UKIDSS Ultra-Deep Survey field. Our aim is to investigate the nature of this rare population of mid-infrared (mid-IR) sources that display such extreme near-to-mid-IR colors. Using up to 17-band photometry (U through 8.0 {mu}m), we have studied in detail their spectral energy distributions, including possible degeneracies in the photometric redshift/internal extinction (z{sub phot}-A{sub V} ) plane. Our sample appears to include sources of very different nature. Between 45% and 75% of them are dust-obscured, massive galaxies at 3 < z{sub phot} < 5. All of the 24 {mu}m detected sources in our sample are in this category. Two of these have S(24 {mu}m)>300 {mu}Jy, which at 3 < z{sub phot} < 5 suggests that they probably host a dust-obscured active galactic nucleus. Our sample also contains four highly obscured (A{sub V} > 5) sources at z{sub phot} < 1. Finally, we analyze in detail two z{sub phot} {approx} 6 galaxy candidates, and discuss their plausibility and implications. Overall, our red galaxy sample contains the tip of the iceberg of a larger population of z > 3 galaxies to be discovered with the future James Webb Space Telescope.

  4. Structure, energetics, and bonding of novel potential high energy density materials Rh2(N5)4: A DFT study

    NASA Astrophysics Data System (ADS)

    Tang, Lihong; Bao, Shuangyou; Peng, Jinhui; Li, Kai; Ning, Ping; Guo, Huibin; Zhu, Tingting; Gu, Junjie; Li, Qianshu

    2015-10-01

    Theoretical studies examining a series of binuclear transition metal pentazolides Rh2(N5)4 predict paddle wheel type structures with very short metal-metal distances. Natural bonding orbital analysis indicated that the bonding between the metal atom and the five-membered ring is predominantly ionic for Rh2(N5)4 species, and a high-order metal-metal multiple bonding exists between the two metal atoms. In addition, the presence of the delocalized π orbital plays an important role in the stabilization of Rh2(N5)4. Nucleus independent chemical shift values confirm that the planar N5- exhibits aromaticity. The dissociation energies into mononuclear fragments are predicted for Rh2(N5)4.

  5. Crystal structure of 5-[(4-carb-oxy-benz-yl)-oxy]isophthalic acid.

    PubMed

    Faizi, Md Serajul Haque; Ahmad, Musheer; Ali, Akram; Potaskalov, Vadim A

    2016-08-01

    The mol-ecular shape of the title compound, C16H12O7, is bent around the central CH2-O bond. The two benzene rings are almost perpendicular to one another, making a dihedral angle of 87.78 (7)°. In the crystal, each mol-ecule is linked to three others by three pairs of O-H⋯O hydrogen bonds, forming undulating sheets parallel to the bc plane and enclosing R 2 (2)(8) ring motifs. The sheets are linked by C-H⋯O hydrogen bonds and C-H⋯π inter-actions, forming a three-dimensional network. PMID:27536418

  6. Clean photodecomposition of 1-methyl-4-phenyl-1H-tetrazole-5(4H)-thiones to carbodiimides proceeds via a biradical

    PubMed Central

    Alawode, Olajide E.; Robinson, Colette; Rayat, Sundeep

    2010-01-01

    The photochemistry of 1-methyl-4-phenyl-1H-tetrazole-5(4H)-thione (1a) and 1-(3-methoxyphenyl)-4-methyl-1H-tetrazole-5(4H)-thione (1b) was studied in acetonitrile at 254 and 300 nm which involves expulsion of dinitrogen and sulfur to form the respective carbodiimides 5a – b as sole photoproducts. Photolysis of the title compounds in the presence of 1,4-cyclohexadiene trap led to the formation of respective thioureas, providing strong evidence for the intermediacy of a 1,3-biradical formed by the loss of dinitrogen. In contrast, a trapping experiment with cyclohexene provided no evidence to support an alternative pathway of photodecomposition involving initial desulfurization followed by loss of dinitrogen via the intermediacy of a carbene. Triplet sensitization and triplet quenching studies argue against the involvement of a triplet excited state. While the quantum yields for the formation of the carbodiimides 5a – b were modest, and showed little change on going from a C6H5 (1a) to mOMeC6H4 (1b) substituent on the tetrazolethione ring, the highly clean photodecomposition of these compounds to a photostable end product makes them promising lead structures for industrial, agricultural and medicinal applications. PMID:21142194

  7. Poly[μ5-(4-meth­oxy­benzene­sulfonato)-sodium

    PubMed Central

    Chantrapromma, Suchada; Boonnak, Nawong; Fun, Hoong-Kun

    2013-01-01

    In the title complex, [Na(C7H7O4S)]n, the NaI ion is coord­inated in a slightly distorted penta­gonal-bipyramidal environment by seven O atoms [Na—O = 2.3198 (16)–2.5585 (17) Å]. The 4-methoxybenzenesulfonate anions act as bis-chelating and bridging ligands, forming a two-dimensional polymer parallel to (001), which is further linked into a three-dimensional network by weak C—H⋯O hydrogen bonds. PMID:24098184

  8. 4-[5-(4-Formyl­phen­oxy)pent­oxy]benzaldehyde

    PubMed Central

    Balić, Tomislav; Marković, Berislav; Balić, Ivana

    2012-01-01

    In the title compound, C20H19O4, the benzene rings, linked via five methyl­ene C atoms, form a dihedral angle of 77.28 (6)°. In the crystal, mol­ecules are linked via pairs of weak C—H⋯O inter­actions [graph set R 2 2(6)] into dimers that are further connected by additional weak C—H⋯O interactions [graph sets R 2 2(14), R 2 2(26) and R 2 2(6)]. PMID:22969559

  9. Synthesis of Substituted 2,3,5,6-tetraarylbenzo(1,2-b:5,4-b')difurans

    NASA Technical Reports Server (NTRS)

    Abdul-Aziz, Mahmoud; Auping, Judith V.; Meador, Michael A.

    1995-01-01

    A series of substituted 2,3,5,6-tetraarylbenzo(l,2-b:5,4-b')difurans 1 was synthesized. This synthesis is based upon the photocyclization of 2,5-dibenzoylresorcinol dibenzyl ethers to the corresponding tetrahydrobenzo(1,2-b:5,4-b')difurans. Treatment of the photoproducts with methanesulfonyl chloride in pyridine afforded 1 in overall yields ranging from 30-72%. A number of these compounds have high fluorescence quantum yields (of phi(sub f) = 0.76-0.90), and their fluorescence spectra exhibit large solvatochromic shifts. These compounds may be suitable for use as fluorescent probes.

  10. Synthesis of a Biologically Active Oxazol-5-(4H)-One via an Erlenmeyer-Plo¨chl Reaction

    ERIC Educational Resources Information Center

    Rodrigues, Catarina A. B.; Martinho, Jose´ M. G.; Afonso, Carlos A. M.

    2015-01-01

    The synthesis of (Z)-4-(4-nitrobenzylidene)-2- phenyloxazol-5(4"H")-one, which is a potent immunomodulator and tyrosinase inhibitor, is described as an experiment for an upper-division undergraduate organic chemistry laboratory course. This compound is produced via an Erlenmeyer-Plo¨chl reaction in the absence of any additional solvents…

  11. Comparing the CarbonTracker and M5-4DVar data assimilation systems for CO2 surface flux inversions

    NASA Astrophysics Data System (ADS)

    Babenhauserheide, A.; Basu, S.; Houweling, S.; Peters, W.; Butz, A.

    2015-09-01

    Data assimilation systems allow for estimating surface fluxes of greenhouse gases from atmospheric concentration measurements. Good knowledge about fluxes is essential to understand how climate change affects ecosystems and to characterize feedback mechanisms. Based on the assimilation of more than 1 year of atmospheric in situ concentration measurements, we compare the performance of two established data assimilation models, CarbonTracker and TM5-4DVar (Transport Model 5 - Four-Dimensional Variational model), for CO2 flux estimation. CarbonTracker uses an ensemble Kalman filter method to optimize fluxes on ecoregions. TM5-4DVar employs a 4-D variational method and optimizes fluxes on a 6° × 4° longitude-latitude grid. Harmonizing the input data allows for analyzing the strengths and weaknesses of the two approaches by direct comparison of the modeled concentrations and the estimated fluxes. We further assess the sensitivity of the two approaches to the density of observations and operational parameters such as the length of the assimilation time window. Our results show that both models provide optimized CO2 concentration fields of similar quality. In Antarctica CarbonTracker underestimates the wintertime CO2 concentrations, since its 5-week assimilation window does not allow for adjusting the distant surface fluxes in response to the detected concentration mismatch. Flux estimates by CarbonTracker and TM5-4DVar are consistent and robust for regions with good observation coverage, regions with low observation coverage reveal significant differences. In South America, the fluxes estimated by TM5-4DVar suffer from limited representativeness of the few observations. For the North American continent, mimicking the historical increase of the measurement network density shows improving agreement between CarbonTracker and TM5-4DVar flux estimates for increasing observation density.

  12. Similar molecular constitutions but different conformations and different supramolecular assemblies in two related fused tetracyclic benzo[b]pyrimido[5,4-f]azepine derivatives.

    PubMed

    Acosta Quintero, Lina M; Burgos, Isidro; Palma, Alirio; Cobo, Justo; Glidewell, Christopher

    2016-01-01

    A simple and effective two-step approach to tricyclic pyrimidine-fused benzazepines has been adapted to give the tetracyclic analogues. In (RS)-8-chloro-6-methyl-1,2,6,7-tetrahydropyrimido[5',4':6,7]azepino[3,2,1-hi]indole, C15H14ClN3, (I), the five-membered ring adopts an envelope conformation, as does the reduced pyridine ring in (RS)-9-chloro-7-methyl-2,3,7,8-tetrahydro-1H-pyrimido[5',4':6,7]azepino[3,2,1-ij]quinoline, C16H16ClN3, (II). However, the seven-membered rings in (I) and (II) adopt very different conformations, with the result that the methyl substituent occupies a quasi-axial site in (I) but a quasi-equatorial site in (II). The molecules of (I) are linked by C-H...N hydrogen bonds to form C(5) chains and inversion-related pairs of chains are linked by a π-π stacking interaction. A combination of a C-H...π hydrogen bond and two C-Cl...π interactions links the molecules of (II) into complex sheets. Comparisons are made with some similar fused heterocyclic compounds. PMID:26742827

  13. The Duck Redux: An Improved Proper-Motion Upper Limit for the Pulsar B1757-24 near the Supernova Remnant G5.4-1.2

    NASA Astrophysics Data System (ADS)

    Blazek, J. A.; Gaensler, B. M.; Chatterjee, S.; van der Swaluw, E.; Camilo, F.; Stappers, B. W.

    2006-12-01

    ``The Duck'' is a complicated nonthermal radio system, consisting of the energetic radio pulsar B1757-24, its surrounding pulsar wind nebula G5.27-0.90, and the adjacent supernova remnant (SNR) G5.4-1.2. PSR B1757-24 was originally claimed to be a young (~15,000 yr) and extreme-velocity (>~1500 km s-1) pulsar, which had penetrated and emerged from the shell of the associated SNR G5.4-1.2 but recent upper limits on the pulsar's motion have raised serious difficulties with this interpretation. We here present 8.5 GHz interferometric observations of the nebula G5.27-0.90 over a 12 yr baseline, doubling the time span of previous measurements. These data correspondingly allow us to halve the previous upper limit on the nebula's westward motion to 14 mas yr-1 (5 σ), allowing a substantive reevaluation of this puzzling object. We rule out the possibility that the pulsar and SNR were formed from a common supernova explosion ~15,000 yr ago, as implied by the pulsar's characteristic age, but conclude that an old (>~70,000 yr) pulsar/SNR association, or a situation in which the pulsar and SNR are physically unrelated, are both still viable explanations.

  14. Fluorescence quenching study of 2,6-bis(5-(4-methylphenyl)-1-H-pyrazol-3-yl)pyridine with metal ions

    NASA Astrophysics Data System (ADS)

    Liu, Hua; Li, Fang-Xiong; Pi, Yan; Wang, Dun-Jia; Hu, Yan-Jun; Zheng, Jing

    2015-06-01

    A novel bispyrazole derivative 2,6-bis(5-(4-methylphenyl)-1-H-pyrazol-3-yl)pyridine was synthesized and its structure was confirmed by 1H NMR, FTIR, MS techniques and elemental analysis. The binding interactions of BMPP with Cd2+, Co2+, Pb2+ and Cu2+ ions were investigated in MeOH-H2O solution by fluorescence quenching technique at two temperatures (25 and 35 °C). Their quenching constants KSV, binding constants K, binding sites n and thermodynamic parameters (ΔH, ΔG and ΔS) were determined. The results indicated that the metal ions quenched the intrinsic fluorescence of the bispyrazole by forming the bispyrazole-metal complexes and their quenching process was a static quenching mechanism. In addition, the process of interaction was spontaneous and mainly ΔS-driven.

  15. Crystal structure of ( Z)-3-methyl-4-((naphth-1-ylamino)methylidene)-1-phenyl-1H-pyrazol-5(4H)-one

    NASA Astrophysics Data System (ADS)

    Sharma, N.; Parihar, S.; Jadeja, R. N.; Kant, R.; Gupta, V. K.

    2015-12-01

    The new pyrazolone derivative, ( Z)-3-methyl-4-((naphthalen-1-ylamino)methylidene)-1-phenyl-1H-pyrazol-5(4H)-one, C21H17N3O, is synthesized, and its crystal structure is determined by X-ray structure analysis. The crystals are orthorhombic, sp. gr. P212121, a = 6.5683(7), b = 12.7384(15), c = 20.198(3) Å, Z = 4, R = 0.0564 for 983 observed reflections. In crystal, the molecule exists in amine-one tautomeric form. The crystal structure is stabilized by N-H···O and C-H···O hydrogen bonds. In addition, C-H···π and π-π-interactions are observed.

  16. Near-achromatic retardance behavior of HN22 Polaroid 3.6 to 5.4 um

    NASA Astrophysics Data System (ADS)

    Lompado, Arthur; Sornsin, Elizabeth A.; Chipman, Russell A.

    1997-10-01

    Polaroid HN22, a popular sheet polarizer, has been measured to be a nearly half wave retarder in the 3.6 to 5.4 micrometers spectral band with a transmittance of approximately 20 percent. The exact retardance value may be tuned to the range of 60 degrees - 260 degrees by tilting the HN22 with respect to the incident beam. The material's polarizing effects have been shown to be minimal in this waveband. Its availability, relatively large available aperture, large filed of view, and low cost make HN22 an excellent candidate for use as an IR retarder for systems operating from 3.6 to 5.4 micrometers . As such, HN22 may be used for rotating the plane of polarization of an incident linearly polarized beam as well as to convert between circular polarization states.

  17. Frequency dependence of the maximum operating temperature for quantum-cascade lasers up to 5.4 THz

    SciTech Connect

    Wienold, M.; Röben, B.; Lü, X.; Rozas, G.; Schrottke, L.; Biermann, K.; Grahn, H. T.

    2015-11-16

    We report on the observation of an approximately linear reduction in the maximum operating temperature with an increasing emission frequency for terahertz quantum-cascade lasers between 4.2 and 5.4 THz. These lasers are based on the same design type, but vary in period length and barrier height for the cascade structure. The sample emitting at the highest frequency around 5.4 THz can be operated in pulsed mode up to 56 K. We identify an additional relaxation channel for electrons by longitudinal optical phonon scattering from the upper to the lower laser level and increasing optical losses toward higher frequencies as major processes, leading to the observed temperature behavior.

  18. Ti(N5)4 as a Potential Nitrogen-Rich Stable High-Energy Density Material.

    PubMed

    Choi, Changhyeok; Yoo, Hae-Wook; Goh, Eun Mee; Cho, Soo Gyeong; Jung, Yousung

    2016-06-23

    We have studied molecular structures and kinetic stabilities of M(N5)3 (M = Sc, Y) and M(N5)4 (M = Ti, Zr, Hf) complexes theoretically. All of these compounds are found to be stable with more than a 13 kcal/mol of kinetic barrier. In particular, Ti(N5)4 showed the largest dissociation energy of 173.0 kcal/mol and thermodynamic stability. This complex had a high nitrogen content (85% by weight), and a significantly high nitrogen to metal ratio (20:1) among the neutral M(N5)n species studied here and in the literature. Ti(N5)4 is thus forecasted to be a good candidate for a nitrogen-rich high-energy density material (HEDM). We reveal in further detail using ab initio molecular dynamics simulations that the dissociation pathways of M(N5)n involve the rearrangements of the bonding configurations before dissociation. PMID:27266258

  19. Form classification

    NASA Astrophysics Data System (ADS)

    Reddy, K. V. Umamaheswara; Govindaraju, Venu

    2008-01-01

    The problem of form classification is to assign a single-page form image to one of a set of predefined form types or classes. We classify the form images using low level pixel density information from the binary images of the documents. In this paper, we solve the form classification problem with a classifier based on the k-means algorithm, supported by adaptive boosting. Our classification method is tested on the NIST scanned tax forms data bases (special forms databases 2 and 6) which include machine-typed and handwritten documents. Our method improves the performance over published results on the same databases, while still using a simple set of image features.

  20. Docking studies and the crystal structure of two tetrazole derivatives: 5-(4-chlorophenyl)-1-{4-(methylsulfonyl)phenyl}-1H-tetrazole and 4-{5-(4-methoxyphenyl)-1H-tetrazol-1-yl}benzenesulfonamide

    NASA Astrophysics Data System (ADS)

    Jawabrah Al-Hourani, Baker; El-Barghouthi, Musa I.; Mcdonald, Robert; Al-Awaida, Wajdy; Wuest, Frank

    2015-12-01

    The structures of 5-(4-chlorophenyl)-1-{4-(methylsulfonyl)phenyl}-1H-tetrazole (3) and 4-{5-(4-methoxyphenyl)-1H-tetrazol-1-yl}benzenesulfonamide (5) have been determined by X-ray crystallography. Tetrazoles 3 and 5 crystallize in the monoclinic space groups Ia and P21/c, respectively. The cell dimensions of azole 3 are a = 11.0413 (5) Å, b = 11.8428 (5) Å, c = 12.2483 (5) Å3, β = 111.7129 (4)°, V = 1487.95 (11) Å3, and Z = 4. Its structure was refined to R1 = 0.0254 (for 3429 observed reflections [I ≥ 2σ(I)]) and wR2 = 0.0651 (for all 3300 unique reflections). The cell dimensions of azole 5 are a = 17.112 (3) Å, b = 6.5904 (10) Å, c = 12.935 (2) Å3, β = 93.1981 (19)°, V = 1456.5 (4) Å3, and Z = 4. Its structure was refined to R1 = 0.0336 (for 3010 observed reflections [I ≥ 2σ(I)]) and wR2 = 0.0875 (for all 2463 unique reflections). The tetrazole rings are essentially planar, while the aryl rings at the 1- and 5-positions of each compound show no conjugation to the tetrazole groups. Compound 5 exhibits a network of intermolecular hydrogen bonds generated by interactions between adjacent sulfonamide groups. The molecular docking studies were carried out to understand the orientation and the interaction of each molecule inside the active site of the cyclooxygenase-2 enzyme, followed by comparison with the bioassay studies as COX-2 inhibitors.

  1. 0.5-4 Å X-RAY BRIGHTENINGS IN THE MAGNETOSPHERE OBSERVED BY THE GEOSTATIONARY OPERATIONAL ENVIRONMENTAL SATELLITES

    SciTech Connect

    Yamamoto, Tetsuya T.; Miyoshi, Y.

    2013-10-01

    We found 217 X-ray brightening events in Earth's magnetosphere. These events occur in the high-energy band (0.5-4 Å) of the Geostationary Operational Environmental Satellite (GOES) X-ray light curves, although GOES X-ray light curves are frequently used as indices of solar flare magnitudes. We found that (1) brightening events are absent in the low-energy band (1-8 Å), unlike those associated with solar flares; and (2) the peak fluxes, durations, and onset times of these events depend on the magnetic local time (MLT). The events were detected in 2006, 2010, and 2011 at around 19-10 MLT, that is, from night to morning. They typically lasted for 2-3 hr. Their peak fluxes are less than 3 × 10{sup –8} W m{sup –2} in the 0.5-4 Å band and are maximized around 0-5 MLT. From these MLT dependencies, we constructed an MLT time profile of X-ray brightening events. Because 0.5-4 and 1-8 Å fluxes were observed and had the same order of magnitude when GOES 14 passed through Earth's shadow, we expected that X-ray brightening events in the 1-8 Å band are obscured by high-background X-ray fluxes coming from the Sun. We also found coincidence between X-ray brightening events and aurora substorms. In the majority of our events, the minimum geomagnetic field values (AL index) are below –400 nT. From these results and consideration of the GOES satellite orbit, we expect that these X-ray brightening events occur in the magnetosphere. We cannot, however, clarify the radiative process of the observed X-ray brightening events.

  2. Permission Forms

    ERIC Educational Resources Information Center

    Zirkel, Perry A.

    2005-01-01

    The prevailing practice in public schools is to routinely require permission or release forms for field trips and other activities that pose potential for liability. The legal status of such forms varies, but they are generally considered to be neither rock-solid protection nor legally valueless in terms of immunity. The following case and the…

  3. Demonstrated 3600 s Integrator Operation with 5.4 μV-s Drift Error for ITER Long Pulse Applications

    NASA Astrophysics Data System (ADS)

    Miller, Kenneth; Ziemba, Timothy; Prager, James; Slobodov, Ilia

    2013-10-01

    Eagle Harbor Technologies has developed a high gain and frequency ultra-stable integrator for small scale concept experiments and long pulse ITER applications. The integrator has a 10 μs RC time with a frequency response greater than 10 MHz. The device has been operated for the 3600 s with a drift error less than 5.4 μV-s, which exceeds the ITER specification. Longer period operation has also been demonstrated (72 hours). Additionally, this integrator has an extremely large dynamic range thereby increasing the effective bit depth of a digitizer. These integrators allow for both the fast and slow magnetic/plasma dynamics to be resolved with a single diagnostic. Software has been written for fast, real-time data acquisition and processing using a field programmable gate array (FPGA). This work is supported by the DOE SBIR/STTR Program.

  4. A brief review of the reflood closure package optimization efforts performed within TRAC 5.4.25R10

    SciTech Connect

    Pimentel, D.A.; Nelson, R.A.

    1997-10-01

    This report summarizes the implementation of tools within Version 5.4.25R10 of the Transient Reactor Analysis Code (TRAC); this implementation allows the semiautomated optimization of the reflood constitutive package. The tools included a software package external to TRAC that used a line search method to minimize a generic function value given the function`s partial derivative vector with respect to a set of closure coefficients used within TRAC`s reflood model. Within TRAC, the generic function was a normalized penalty function dependent on time averaged calculated values of vapor temperature, vapor void fraction, wall to a fluid heat transfer rate (or wall temperature), and the respective steady state data. The penalty function was implemented only for a one dimensional vessel configuration because the available reflood data were taken primarily from postcritical heat flux tube experiments.

  5. 41 CFR 304-5.4 - May we authorize an employee to exceed the maximum subsistence allowances (per diem or actual...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 4 2014-07-01 2014-07-01 false May we authorize an employee to exceed the maximum subsistence allowances (per diem or actual expense) prescribed in applicable travel regulations where we have authorized acceptance of payment from a non-Federal source for such allowances? 304-5.4 Section 304-5.4...

  6. Ba2AsGaSe5: A New Quaternary Selenide with the Novel [AsGaSe5](4-) Cluster and Interesting Photocatalytic Properties.

    PubMed

    Li, Chao; Li, Xiaoshuang; Huang, Hongwei; Yao, Jiyong; Wu, Yicheng

    2015-10-19

    The new zero-dimensional selenide Ba2AsGaSe5 was synthesized via a solid-state reaction at 900 °C. It belongs to the orthorhombic space group Pnma with a = 12.632(3) Å, b = 8.9726(18) Å, c = 9.2029(18) Å, and Z = 4. In the structure, the As atom adopts trigonal-pyramidal coordination owing to the stereochemically active 4s(2) lone pair electrons and the Ga atom is tetrahedrally coordinated with four Se atoms. The AsSe3 trigonal pyramids share edges with GaSe4 tetrahedra to form novel [AsGaSe5](4-) clusters, which are further separated from each other by Ba(2+) cations. The optical band gap was determined as 1.39 eV according to UV-vis-NIR diffuse reflectance spectroscopy. Interestingly, the photocatalytic behavior investigated by decomposing rhodamine B indicates that the compound displays a 6.5 times higher photocatalytic activity than does P25. PMID:26418301

  7. Greener Selective Cycloalkane Oxidations with Hydrogen Peroxide Catalyzed by Copper-5-(4-pyridyl)tetrazolate Metal-Organic Frameworks.

    PubMed

    Martins, Luísa; Nasani, Rajendar; Saha, Manideepa; Mobin, Shaikh; Mukhopadhyay, Suman; Pombeiro, Armando

    2015-01-01

    Microwave assisted synthesis of the Cu(I) compound [Cu(µ₄-4-ptz)]n [1, 4-ptz=5-(4-pyridyl)tetrazolate] has been performed by employing a relatively easy method and within a shorter period of time compared to its sister compounds. The syntheses of the Cu(II) compounds [Cu₃(µ₃-4-ptz)₄(µ₂-N₃)₂(DMF)₂]n∙(DMF)2n (2) and [Cu(µ₂-4-ptz)₂(H₂O)₂]n (3) using a similar method were reported previously by us. MOFs 1-3 revealed high catalytic activity toward oxidation of cyclic alkanes (cyclopentane, -hexane and -octane) with aqueous hydrogen peroxide, under very mild conditions (at room temperature), without any added solvent or additive. The most efficient system (2/H₂O₂) showed, for the oxidation of cyclohexane, a turnover number (TON) of 396 (TOF of 40 h(-1)), with an overall product yield (cyclohexanol and cyclohexanone) of 40% relative to the substrate. Moreover, the heterogeneous catalytic systems 1-3 allowed an easy catalyst recovery and reuse, at least for four consecutive cycles, maintaining ca. 90% of the initial high activity and concomitant high selectivity. PMID:26506333

  8. Architecture overview and data summary of a 5.4 km free-space laser communication experiment

    NASA Astrophysics Data System (ADS)

    Moores, John D.; Walther, Frederick G.; Greco, Joseph A.; Michael, Steven; Wilcox, William E., Jr.; Volpicelli, Alicia M.; Magliocco, Richard J.; Henion, Scott R.

    2009-08-01

    MIT Lincoln Laboratory designed and built two free-space laser communications terminals, and successfully demonstrated error-free communication between two ground sites separated by 5.4 km in September, 2008. The primary goal of this work was to emulate a low elevation angle air-to-ground link capable of supporting standard OTU1 (2.667 Gb/s) data formatting with standard client interfaces. Mitigation of turbulence-induced scintillation effects was accomplished through the use of multiple small-aperture receivers and novel encoding and interleaver hardware. Data from both the field and laboratory experiments were used to assess link performance as a function of system parameters such as transmitted power, degree of spatial diversity, and interleaver span, with and without forward error correction. This work was sponsored by the Department of Defense, RRCO DDR&E, under Air Force Contract FA8721-05-C-0002. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the United States Government.

  9. Fourier transform and Vernier spectroscopy using an optical frequency comb at 3-5.4  μm.

    PubMed

    Khodabakhsh, Amir; Ramaiah-Badarla, Venkata; Rutkowski, Lucile; Johansson, Alexandra C; Lee, Kevin F; Jiang, Jie; Mohr, Christian; Fermann, Martin E; Foltynowicz, Aleksandra

    2016-06-01

    We present a versatile mid-infrared frequency comb spectroscopy system based on a doubly resonant optical parametric oscillator tunable in the 3-5.4 μm range and two detection methods: a Fourier transform spectrometer (FTS) and a continuous-filtering Vernier spectrometer (CF-VS). Using the FTS with a multipass cell, we measure high precision broadband absorption spectra of CH4 at 3.3 μm and NO at 5.25 μm, the latter for the first time with comb spectroscopy, and we detect atmospheric species (CH4, CO, CO2, and H2O) in air in the signal and idler ranges. Multiline fitting yields minimum detectable concentrations of 10-20  ppb Hz-1/2 for CH4, NO, and CO. For the first time in the mid-infrared, we perform CF-VS using an enhancement cavity, a grating, and a single detector, and we measure the absorption spectrum of CH4 and H2O in ambient air at ∼3.3  μm, reaching a 40 ppb concentration detection limit for CH4 in 2 ms. PMID:27244409

  10. Thermal emission spectra of Mars (5.4-10.5 microns) - Evidence for sulfates, carbonates, and hydrates

    NASA Technical Reports Server (NTRS)

    Pollack, James B.; Roush, Ted; Witteborn, Fred; Bregman, Jesse; Wooden, Diane; Stoker, Carol; Toon, Owen B.

    1990-01-01

    Spectra of the Martian thermal emission in the 5.4-10.5 micron region are reported. Emission features at 7.8 and 9.7 microns are attributed to surface silicates, and an emission feature at 6.1 micron is attributed to a molecular water component of the surface material. An absorption band at 8.7 micron and a possible one at 9.8 microns is attributed to sulfate or bisulfate anions probably located at a distorted crystalline site, and an absorption band at 6.7 microns is attributed to carbonate or bicarbonate anions located in a distorted crystalline site. Spectral simulations indicate that the sulfate- and carbonate-bearing minerals are contained in the same particles of airborne dust as the dominant silicate minerals, that the dust optical depth is about 0.6 at a reference wavelength of 0.3 micron over the area of the observed spots, and that sulfates and carbonates constitute 10-15 percent and 1-3 percent by volume of the airborne dust, respectively.

  11. Fluorescent labeling of cranberry proanthocyanidins with 5-([4,6-dichlorotriazin-2-yl]amino)fluorescein (DTAF).

    PubMed

    Feliciano, Rodrigo P; Heintz, Joseph A; Krueger, Christian G; Vestling, Martha M; Reed, Jess D

    2015-01-01

    A novel methodology was developed to elucidate proanthocyanidins (PAC) interaction with extra-intestinal pathogenic Escherichia coli (ExPEC). PAC inhibit ExPEC invasion of epithelial cells and, therefore, may prevent transient gut colonization, conferring protection against subsequent extra-intestinal infections, such as urinary tract infections. Until now PAC have not been chemically labeled with fluorophores. In this work, cranberry PAC were labeled with 5-([4,6-dichlorotriazin-2-yl]amino) fluorescein (DTAF), detected by high-performance liquid chromatography with diode-array detection and characterized by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). We report single and double fluorescent-labeled PAC with one or two chlorine atoms displaced from DTAF in alkaline pH via nucleophilic substitution. Fluorescent labeling was confirmed by fragmentation experiments using MALDI-TOF/TOF MS. Fluorescent labeled PAC were able to promote ExPEC agglutination when observed with fluorescence microscopy. DTAF tagged PAC may be used to trace the fate of PAC after they agglutinate ExPEC and follow PAC-ExPEC complexes in cell culture assays. PMID:25053065

  12. Conformational search, spectral analysis and electronic properties of 5-(4-Pyridinyl)-1,3,4-thiadiazol-2-amine

    NASA Astrophysics Data System (ADS)

    Shukla, Vikas K.; Al-Alshaikh, Monirah A.; El-Emam, Ali A.; Sachan, Alok K.; Srivastava, Ruchi; Prasad, Onkar; Sinha, Leena

    2016-03-01

    Comprehensive investigation of molecular geometry and electronic structure of 5-(4-Pyridinyl)-1,3,4-thiadiazol-2-amine in ground as well as in the first excited state has been carried out. The stable conformers of the title compound have been determined from the 3D potential energy scan by varying selected dihedral angles, responsible for conformational flexibility. As the energy difference between the conformers was very small, the relative stability has been confirmed at potentially high-level G2MP2 method. The most stable structure was optimized with B3LYP and M06-2X functional using polarized triple-zeta 6-311++G(d,p), to obtain the ground state structure and calculation of vibrational wavenumbers. Experimental FT-IR and FT-Raman spectra were compared with theoretical spectral data. Dipole moment, polarizability, first static hyperpolarizability and molecular electrostatic potential surface map have been calculated to get a better insight of the properties of title molecule. Frequency-dependent first hyperpolarizability β(-2ω;ω,ω) has also been evaluated to gauge the non-linear optical behavior of the title compound. Natural bond orbital (NBO) analysis has been done to study the stability of the compound arising from charge delocalization. UV-Vis spectrum, possible solvent-solute interaction and electronic properties such as frontier orbitals, band gap energies have been calculated by TD-DFT approach. 1H nuclear magnetic resonance chemical shifts of the title compound were calculated using the Gauge-Including Atomic Orbital (GIAO) method and compared with experimental data.

  13. Geodetically inferred coseismic and postseismic slip due to the M 5.4 31 October 2007 Alum Rock earthquake

    USGS Publications Warehouse

    Murray-Moraleda, J. R.; Simpson, R.W.

    2009-01-01

    On 31 October 2007 the M 5.4 Alum Rock earthquake occurred near the junction between the Hayward and Calaveras faults in the San Francisco Bay Area, producing coseismic and postseismic displacements recorded by 10 continuously operating Global Positioning System (GPS) instruments. The cumulative postseismic displacements over the four months following the earthquake are linearly related to the cumulative number of aftershocks and are comparable in magnitude to the coseis mic displacements. The postseismic signal suggests that, in addition to afterslip at seismogenic depths, localized right-lateral/reverse slip occurred on dipping shallow fault surfaces southwest of the Calaveras. The spatial distribution of slip inferred by inverting the GPS data is compatible with a model in which moderate Calaveras fault earthquakes rupture locked patches surrounded by areas of creep, afterslip, and microseismicity (Oppenheimer et al., 1990). If this model and existing Calaveras fault slip rate estimates are correct, a slip deficit remains on the 2007 Alum Rock rupture patch that may be made up by aseismic slip or slip in larger earthquakes. Recent studies (e.g., Manaker et al., 2005) suggest that at depth the Hayward and central Calaveras faults connect via a simple continuous surface illuminated by the Mission Seismic Trend (MST), implying that a damaging earthquake rupture could involve both faults (Graymer et al., 2008). If this geometry is correct, the combined coseismic and postseismic slip we infer for the 2007 Alum Rock event predicts static Coulomb stress increases of ???0:6 bar on the MST surface and on the northern Calaveras fault ???5 km northwest of the Alum Rock hypocenter.

  14. [1H-1,2,4-Triazole-5(4H)-thione-κS]bis­(tri­phenyl­phosphane-κP)(nitrato-κO)silver(I) methanol monosolvate

    PubMed Central

    Wattanakanjana, Yupa; Palamae, Sureeporn; Ratthiwan, Jenejira; Nimthong, Ruthairat

    2014-01-01

    In the title complex, [Ag(NO3)(C2H3N3S)(C18H15P)2]·CH3OH, the AgI ion exhibits a distorted tetra­hedral coordination geometry formed by two P atoms from two tri­phenyl­phosphine ligands, one S atom from a 1H-1,2,4-triazole-5(4H)-thione ligand and one O atom from a nitrate ion. In the crystal, complex and solvent mol­ecules are linked by O—H⋯O and N—H⋯O hydrogen bonds forming a chain along the b-axis direction. The chains are linked by weak C—H⋯O hydrogen bonds forming a two-dimensional supra­molecular architecture parallel to (001). In addition, an intra­molecular N—H⋯O hydrogen bond is observed. PMID:24764826

  15. Tidal Forms

    NASA Astrophysics Data System (ADS)

    Bolla Pittaluga, M.; Seminara, G.; Tambroni, N.

    2003-04-01

    We give an overview of some recent investigations on the mechanics of the processes whereby forms develop in tidal environments. The viewpoint taken here is mechanistic. Some of the questions which deserve an answer may be summarised as follows: i) do tidal channels tend to some altimetric long term equilibrium? ii) why are they typically convergent and weakly meandering? iii) how is such equilibrium affected by the hydrodynamics and morphodynamics of tidal inlets? iv) what is the hydrodynamic and morphodynamic role played by tidal flats adjacent to the channels? Some of the above questions have received a considerable attention in the last few years. Schuttelaars and de Swart (1996), Lanzoni and Seminara (2002) and, more recently, Bolla Pittaluga (2003) have investigated the first problem. In particular, the latter two contributions have shown that a straight tidal channel connected to a tidal sea at one end and closed at the other end tends to reach a long term equilibrium profile, which is slightly concave seaward and convex landward where a beach forms. The equilibrium profile is strongly sensitive to the harmonic content of the tidal forcing as well as to the value of sediment concentration established by the coastal hydrodynamics in the far field of the inlet region. Less important are the effect of channel convergence and the role of settling lag in the transport of suspended load. Insufficient attention has been devoted to the understanding of what mechanisms control channel convergence and meandering, though some similarities and differences between tidal and fluvial channels have emerged from some recent works. In particular, free bars form in tidal channels due to an instability mechanism essentially similar to that occurring under steady conditions though the oscillatory character of the flow field makes the bar pattern non migrating (Seminara and Tubino, 2001). Similarly, forced bars in curved tidal channels are driven by the development of

  16. Evaluation of North Eurasian snow-off dates in the ECHAM5.4 atmospheric general circulation model

    NASA Astrophysics Data System (ADS)

    Räisänen, P.; Luomaranta, A.; Järvinen, H.; Takala, M.; Jylhä, K.; Bulygina, O. N.; Luojus, K.; Riihelä, A.; Laaksonen, A.; Koskinen, J.; Pulliainen, J.

    2014-12-01

    The timing of springtime end of snowmelt (snow-off date) in northern Eurasia in version 5.4 of the ECHAM5 atmospheric general circulation model (GCM) is evaluated through comparison with a snow-off date data set based on space-borne microwave radiometer measurements and with Russian snow course data. ECHAM5 reproduces well the observed gross geographical pattern of snow-off dates, with earliest snow-off (in March) in the Baltic region and latest snow-off (in June) in the Taymyr Peninsula and in northeastern parts of the Russian Far East. The primary biases are (1) a delayed snow-off in southeastern Siberia (associated with too low springtime temperature and too high surface albedo, in part due to insufficient shielding by canopy); and (2) an early bias in the western and northern parts of northern Eurasia. Several sensitivity experiments were conducted, where biases in simulated atmospheric circulation were corrected through nudging and/or the treatment of surface albedo was modified. While this alleviated some of the model biases in snow-off dates, 2 m temperature and surface albedo, especially the early bias in snow-off in the western parts of northern Eurasia proved very robust and was actually larger in the nudged runs. A key issue underlying the snow-off biases in ECHAM5 is that snowmelt occurs at too low temperatures. Very likely, this is related to the treatment of the surface energy budget. On one hand, the surface temperature Ts is not computed separately for the snow-covered and snow-free parts of the grid cells, which prevents Ts from rising above 0 °C before all snow has vanished. Consequently, too much of the surface net radiation is consumed in melting snow and too little in heating the air. On the other hand, ECHAM5 does not include a canopy layer. Thus, while the albedo reduction due to canopy is accounted for, the shielding of snow on ground by the overlying canopy is not considered, which leaves too much solar radiation available for melting snow.

  17. Crystal structure of 5-[(4-carb­oxy­benz­yl)­oxy]isophthalic acid

    PubMed Central

    Faizi, Md. Serajul Haque; Ahmad, Musheer; Ali, Akram; Potaskalov, Vadim A.

    2016-01-01

    The mol­ecular shape of the title compound, C16H12O7, is bent around the central CH2—O bond. The two benzene rings are almost perpendicular to one another, making a dihedral angle of 87.78 (7)°. In the crystal, each mol­ecule is linked to three others by three pairs of O—H⋯O hydrogen bonds, forming undulating sheets parallel to the bc plane and enclosing R 2 2(8) ring motifs. The sheets are linked by C—H⋯O hydrogen bonds and C—H⋯π inter­actions, forming a three-dimensional network. PMID:27536418

  18. 5-(4-Methyl­phen­yl)-3-phenyl­cyclo­hex-2-en-1-one

    PubMed Central

    Mohamed, Shaaban K.; Akkurt, Mehmet; Abdelhamid, Antar A; Singh, Kuldip; Allah, Omyma A. A. Abd

    2012-01-01

    In the title compound, C19H18O, the cyclo­hexene ring has an envelope conformation with the methine C atom on the flap. The phenyl and methyl­phenyl rings form a dihedral angle of 85.93 (11)°. The crystal packing is consolidated by van der Waals forces and weak C—H⋯π inter­actions. PMID:22798829

  19. VizieR Online Data Catalog: TW Hya CO (2-1), CN (2-1) and CS (5-4) data cubes (Teague+, 2016)

    NASA Astrophysics Data System (ADS)

    Teague, R.; Guilloteau, S.; Semenov, D.; Henning, T.; Dutrey, A.; Pietu, V.; Birnstiel, T.; Chapillon, E.; Hollenbach, D.; Gorti, U.

    2016-07-01

    The observations were performed using ALMA on May 13, 2015 under excellent weather conditions (Cycle 2, 2013.1.00387.S). The receivers were tuned to cover CO J=(2-1), CS J=(5-4) and all strong hyperfine components of CN N=(2-1) simultaneously. The correlator was configured to deliver very high spectral resolution, with a channel spacing of 15kHz (and an effective velocity resolution of 40m/s) for the CO J=(2-1) and CS J=(5-4) lines, and 30kHz (80m/s) for the CN N=(2-1) transition. (2 data files).

  20. [Influence of metal ions on stability of 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside contained in Polygoni Multiflori Radix].

    PubMed

    Li, Rui-yu; Feng, Wu-wen; Li, Xiao-fei; Zhang, Ding-kun; Li, Chun-yu; Meng, Ya-kun; Bai, Zhao-fang; Song, Hai-bo; Du, Xiao-xi; Xia, Hou-lin; Wang, Jia-bo; Xiao, Xiao-he

    2016-01-01

    Decoction is one of the most commonly used dosage forms of traditional Chinese medicine. The stability of chemical constituents in decoction is closely related to the clinical efficacy and safety. There were few reports about the influence of metal ions in the stability of chemical constituents in traditional Chinese medicine. However, there is no evidence that metal ions in decoction water need to be controlled. In this study, 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside (THSG), one of the main constituents in Polygoni Multiflori Radix was studied. Ordinary tap water, deionized water, and water containing different metal ions were used to investigate and compare the influence on THSG. The results showed that after storage in a dark place at the room temperature for 10 days, the degradation of THSG was 7% in deionized water, while undetectable in tap water. The content of THSG could be decreased by different kinds of metal ions, and the effect was concentration-dependent. Moreover, Fe3+ and Fe2+ showed the greatest influence at the same concentration; and our study has shown that THSG decreased more than 98% in Fe and Fe2+ solutions at 500 ppm concentration. In the same time we found out p-hydroxybenzaldehyde (molecular weight: 122.036 7) and 2,3,5-trihydroxybenzaldehyde-2-O-glycoside (molecular weight: 316.079 4) were the main degradation products of THSG in tap water and water containing Cu2+, Ca2+, Zn2+, Mg2+ and Al3+. The product of THSG dimer with a water molecule was found in water containing Fe3+ and Fe2+. The above results showed that the metal ions in water could significantly influence the stability of THSG in water, indicating that the clinical efficacy and safety of decoction would be affected if the metal ions in water were not under control. It's suggested that deionized water should be used in the preparation of decoction containing Polygoni Multiflori Radix in the clinic to avoid degradation of THSG. Meanwhile, decoction prepared by tap water

  1. Institutions in the Colonial Era. Grade 5 Model Lesson for Standard 5.4. California History-Social Science Course Models.

    ERIC Educational Resources Information Center

    Zachlod, Michelle, Ed.

    California State Standard 5.4 is delineated as: Students understand the political, religious, social, and economic institutions that evolved in the colonial era. Understanding the historical contributions of religion and key elements of world religions is essential to a complete knowledge of America's civilization and to being a well educated…

  2. Synthesis of 2H-Azirines by Iridium-Catalyzed Decarboxylative Ring Contraction of Isoxazol-5(4H)-ones.

    PubMed

    Okamoto, Kazuhiro; Shimbayashi, Takuya; Yoshida, Masato; Nanya, Atsushi; Ohe, Kouichi

    2016-06-13

    A phosphine-free iridium-catalyzed reaction of isoxazol-5(4H)-ones (isoxazolones) has been developed, and affords 2H-azirines through decarboxylation and ring contraction. This method provides an efficient and environmentally benign protocol which could replace the conventional approaches used to synthesize 2H-azirines. PMID:27125870

  3. Five closely related 4-chloro-6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepines: similar molecular structures but different supramolecular assemblies.

    PubMed

    Acosta, Lina M; Jurado, Jorge; Palma, Alirio; Cobo, Justo; Glidewell, Christopher

    2015-12-01

    Dibenz[b,f]azepine (DBA) is a privileged 6-7-6 tricyclic ring system of importance in both organic and medicinal chemistry. Benzo[b]pyrimido[5,4-f]azepines (BPAs), which also contain a privileged 6-7-6 ring system, are less well investigated, probably because of a lack of straightforward and versatile methods for their synthesis. A simple and versatile synthetic approach to BPAs based on intramolecular Friedel-Crafts alkylation has been developed. A group of closely-related benzo[b]pyrimido[5,4-f]azepine derivatives, namely (6RS)-4-chloro-6,11-dimethyl-6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepine, C14H14ClN3, (I), (6RS)-4-chloro-8-hydroxy-6,11-dimethyl-6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepine, C14H14ClN3O, (II), (6RS)-4-chloro-8-methoxy-6,11-dimethyl-6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepine, C15H16ClN3O, (III), and (6RS)-4-chloro-8-methoxy-6,11-dimethyl-2-phenyl-6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepine, C21H20ClN3O, (IV), has been prepared and their structures compared with the recently published structure [Acosta-Quintero et al. (2015). Eur. J. Org. Chem. pp. 5360-5369] of (6RS)-4-chloro-2,6,8,11-tetramethyl-6,11-dihydro-5H-benzo[b]pyrimido[5,4-f]azepine, (V). All five compounds crystallize as racemic mixtures and they have very similar molecular conformations, with the azepine ring adopting a boat-type conformation in each case, although the orientation of the methoxy substituent in each of (III) and (IV) is different. The supramolecular assemblies in (II) and (IV) depend upon hydrogen bonds of the O-H...N and C-H...π(arene) types, respectively, those in (I) and (V) depend upon π-π stacking interactions involving pairs of pyrimidine rings, and that in (III) depends upon a π-π stacking interaction involving pairs of phenyl rings. Short C-Cl...π(pyrimidine) contacts are present in (I), (II) and (IV) but not in (III) or (V). PMID:26632832

  4. Densified waste form and method for forming

    DOEpatents

    Garino, Terry J.; Nenoff, Tina M.; Sava Gallis, Dorina Florentina

    2016-05-17

    Materials and methods of making densified waste forms for temperature sensitive waste material, such as nuclear waste, formed with low temperature processing using metallic powder that forms the matrix that encapsulates the temperature sensitive waste material. The densified waste form includes a temperature sensitive waste material in a physically densified matrix, the matrix is a compacted metallic powder. The method for forming the densified waste form includes mixing a metallic powder and a temperature sensitive waste material to form a waste form precursor. The waste form precursor is compacted with sufficient pressure to densify the waste precursor and encapsulate the temperature sensitive waste material in a physically densified matrix.

  5. Densified waste form and method for forming

    SciTech Connect

    Garino, Terry J.; Nenoff, Tina M.; Sava Gallis, Dorina Florentina

    2015-08-25

    Materials and methods of making densified waste forms for temperature sensitive waste material, such as nuclear waste, formed with low temperature processing using metallic powder that forms the matrix that encapsulates the temperature sensitive waste material. The densified waste form includes a temperature sensitive waste material in a physically densified matrix, the matrix is a compacted metallic powder. The method for forming the densified waste form includes mixing a metallic powder and a temperature sensitive waste material to form a waste form precursor. The waste form precursor is compacted with sufficient pressure to densify the waste precursor and encapsulate the temperature sensitive waste material in a physically densified matrix.

  6. 22 CFR 5.3 - Rules of procedure, description of forms available or the places at which forms may be obtained...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... papers, reports, or examinations. 5.3 Section 5.3 Foreign Relations DEPARTMENT OF STATE GENERAL ORGANIZATION § 5.3 Rules of procedure, description of forms available or the places at which forms may be... referenced in § 5.4, or obtained upon application to the offices listed below. Forms pertaining to...

  7. 22 CFR 5.3 - Rules of procedure, description of forms available or the places at which forms may be obtained...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... papers, reports, or examinations. 5.3 Section 5.3 Foreign Relations DEPARTMENT OF STATE GENERAL ORGANIZATION § 5.3 Rules of procedure, description of forms available or the places at which forms may be... referenced in § 5.4, or obtained upon application to the offices listed below. Forms pertaining to...

  8. 22 CFR 5.3 - Rules of procedure, description of forms available or the places at which forms may be obtained...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... papers, reports, or examinations. 5.3 Section 5.3 Foreign Relations DEPARTMENT OF STATE GENERAL ORGANIZATION § 5.3 Rules of procedure, description of forms available or the places at which forms may be... referenced in § 5.4, or obtained upon application to the offices listed below. Forms pertaining to...

  9. 22 CFR 5.3 - Rules of procedure, description of forms available or the places at which forms may be obtained...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... papers, reports, or examinations. 5.3 Section 5.3 Foreign Relations DEPARTMENT OF STATE GENERAL ORGANIZATION § 5.3 Rules of procedure, description of forms available or the places at which forms may be... referenced in § 5.4, or obtained upon application to the offices listed below. Forms pertaining to...

  10. 22 CFR 5.3 - Rules of procedure, description of forms available or the places at which forms may be obtained...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... papers, reports, or examinations. 5.3 Section 5.3 Foreign Relations DEPARTMENT OF STATE GENERAL ORGANIZATION § 5.3 Rules of procedure, description of forms available or the places at which forms may be... referenced in § 5.4, or obtained upon application to the offices listed below. Forms pertaining to...

  11. The Use of 3,5,4′-Tri-O-acetylresveratrol as a Potential Prodrug for Resveratrol Protects Mice from γ-Irradiation-Induced Death

    PubMed Central

    2011-01-01

    Currently, no drugs are available to protect humans from γ-irradiation-induced death. Because reactive oxygen species are produced upon exposure to γ-irradiation and directly responsible for the resulting death, we hypothesized that antioxidants found in foodstuffs may provide a safe and potent means of antioxidant-dependent radioprotection. Here, we describe our studies investigating the radioprotective properties of resveratrol and 3,5,4′-tri-O-acetylresveratrol. Each of these natural antioxidants was found to protect live cells after γ-irradiation. In mice, the use of 3,5,4′-tri-O-acetylresveratrol with Cremophor EL was particularly effective, indicating that this natural antioxidant may be a leading candidate for radioprotective drug development. PMID:21826253

  12. The Use of 3,5,4'-Tri-O-acetylresveratrol as a Potential Pro-drug for Resveratrol Protects Mice from γ-Irradiation-Induced Death.

    PubMed

    Koide, Kazunori; Osman, Sami; Garner, Amanda L; Song, Fengling; Dixon, Tracy; Greenberger, Joel S; Epperly, Michael W

    2011-01-25

    Currently, no drugs are available to protect humans from γ-irradiation-induced death. Because reactive oxygen species are produced upon exposure to γ-irradiation and directly responsible for the resulting death, we hypothesized that antioxidants found in foodstuffs may provide a safe and potent means of antioxidant-dependent radioprotection. Here, we describe our studies investigating the radioprotective properties of resveratrol and 3,5,4'-tri-O-acetylresveratrol. Each of these natural antioxidants was found to protect live cells after γ-irradiation. In mice, the use of 3,5,4'-tri-O-acetylresveratrol with Cremophor EL was particularly effective, indicating that this natural antioxidant may be a leading candidate for radioprotective drug development. PMID:21826253

  13. Nuclear magnetic resonance study of the ferroelastic phase transition of order-disorder type in [N(C2H5)4]2CdCl4

    NASA Astrophysics Data System (ADS)

    Lim, Ae Ran; Kim, Min Soo; Lim, Kye-Young

    2016-08-01

    This study uses nuclear magnetic resonance (NMR) techniques to examine the detailed changes in [N(C2H5)4]2CdCl4 around its phase transition at the temperature TC = 284 K. The chemical shifts and spin-lattice relaxation times in the rotating frame (T1ρ) were determined from 1H magic angle spinning (MAS) NMR and 13C cross-polarization (CP)/MAS NMR spectra. The two sets of inequivalent 1H and 13C nuclei in CH3 and CH2 were distinguished. A ferroelastic phase transition was observed at TC, without structural symmetry change. The phase transition is mainly attributed to the orientational ordering of the [N(C2H5)4]+ cations, and the spectral splitting at low temperature is associated with different ferroelastic domains.

  14. Careers (A Course of Study). Unit V: Forms, Forms, Forms.

    ERIC Educational Resources Information Center

    Turley, Kay

    Designed to enable special needs students to understand and complete various job-related forms, this set of activities devoted to forms encountered before and after one obtains a job is the fifth in a nine-unit secondary level careers course intended to provide handicapped students with the knowledge and tools necessary to succeed in the world of…

  15. Mid-IR supercontinuum from 2.4 to 5.4 μm in a low-loss fluoroindate fiber.

    PubMed

    Gauthier, Jean-Christophe; Fortin, Vincent; Carrée, Jean-Yves; Poulain, Samuel; Poulain, Marcel; Vallée, Réal; Bernier, Martin

    2016-04-15

    A mid-infrared supercontinuum extending up to 5.4 μm is generated in a low-loss fluoroindate fiber. It is pumped with an erbium-doped fluoride fiber amplifier seeded with 400 ps pulses at 2.75 μm. Both fibers are fusion spliced to increase the robustness and long-term stability of the system. With more than 82% of the total power beyond 3 μm, this approach is promising for efficient mid-IR light generation. PMID:27082337

  16. A physical model for the precursory magnetic anomalies of the M5.4 Alum Rock and M6.0 Parkfield earthquakes

    NASA Astrophysics Data System (ADS)

    Dologlou, Elizabeth

    2014-06-01

    Here, we propose an alternative physical model, based on the concept of criticality, for the explanation of the observed magnetic signals prior to the M6.0 Parkfield and the M5.4 Alum Rock earthquakes. Motivated by an analogous experience from major earthquakes in Greece, where both magnetic field variations and seismic electric signals were also recorded few weeks before the main shock, we suggest that in all these cases, similar dynamic processes characterized by critical behaviour should govern the corresponding pre-focal areas when the relevant precursory signals emerged.

  17. Biological Activities of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments.

    PubMed

    Ling, Shuang; Xu, Jin-Wen

    2016-01-01

    2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) is active component of the Chinese medicinal plant Polygonum multiflorum Thunb. (THSG). Pharmacological studies have demonstrated that THSG exhibits numerous biological functions in treating atherosclerosis, lipid metabolism, vascular and cardiac remodeling, vascular fibrosis, cardiac-cerebral ischemia, learning and memory disorders, neuroinflammation, Alzheimer and Parkinson diseases, diabetic complications, hair growth problems, and numerous other conditions. This review focuses on the biological effects of THSG in antiaging and antiaging-related disease treatments and discusses its molecular mechanisms. PMID:27413420

  18. Biological Activities of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-Glucoside in Antiaging and Antiaging-Related Disease Treatments

    PubMed Central

    2016-01-01

    2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) is active component of the Chinese medicinal plant Polygonum multiflorum Thunb. (THSG). Pharmacological studies have demonstrated that THSG exhibits numerous biological functions in treating atherosclerosis, lipid metabolism, vascular and cardiac remodeling, vascular fibrosis, cardiac-cerebral ischemia, learning and memory disorders, neuroinflammation, Alzheimer and Parkinson diseases, diabetic complications, hair growth problems, and numerous other conditions. This review focuses on the biological effects of THSG in antiaging and antiaging-related disease treatments and discusses its molecular mechanisms. PMID:27413420

  19. A 1.5-4 K detachable cold-sample transfer system: Application to inertially confined fusion with spin-polarized hydrogen fuels

    NASA Astrophysics Data System (ADS)

    Alexander, N.; Barden, J.; Fan, Q.; Honig, A.

    1991-11-01

    A compact cold-transfer apparatus for engaging and retrieving samples at liquid-helium temperatures (1.5-4 K), maintaining the samples at such temperatures for periods of hours, and subsequently inserting them in diverse apparatuses followed by disengagement, is described. The properties of several thermal radiation-insulating shrouds, necessary for very low sample temperatures, are presented. The immediate intended application is transportable target shells containing highly spin-polarized deuterons in solid HD or D2 for inertially confined fusion experiments. The system is also valuable for unpolarized high-density fusion fuels, as well as for other applications which are discussed.

  20. A 1. 5--4 Kelvin detachable cold-sample transfer system: Application to inertially confined fusion with spin-polarized hydrogens fuels

    SciTech Connect

    Alexander, N.; Barden, J.; Fan, Q.; Honig, A.

    1990-01-01

    A compact cold-transfer apparatus for engaging and retrieving samples at liquid helium temperatures (1.5--4K), maintaining the samples at such temperatures for periods of hours, and subsequently inserting them in diverse apparatuses followed by disengagement, is described. The properties of several thermal radiation-insulating shrouds, necessary for very low sample temperatures, are presented. The immediate intended application is transportable target-shells containing highly spin-polarized deuterons in solid HD or D{sub 2} for inertially confined fusion (ICF) experiments. The system is also valuable for unpolarized high-density fusion fuels, as well as for other applications which are discussed. 9 refs., 6 figs.

  1. A 1. 5--4 K detachable cold-sample transfer system: Application to inertially confined fusion with spin-polarized hydrogen fuels

    SciTech Connect

    Alexander, N.; Barden, J.; Fan, Q.; Honig, A. )

    1991-11-01

    A compact cold-transfer apparatus for engaging and retrieving samples at liquid-helium temperatures (1.5--4 K), maintaining the samples at such temperatures for periods of hours, and subsequently inserting them in diverse apparatuses followed by disengagement, is described. The properties of several thermal radiation-insulating shrouds, necessary for very low sample temperatures, are presented. The immediate intended application is transportable target shells containing highly spin-polarized deuterons in solid HD or D{sub 2} for inertially confined fusion experiments. The system is also valuable for unpolarized high-density fusion fuels, as well as for other applications which are discussed.

  2. Dispersive liquid-liquid microextraction of lead(II) as 5-(4-dimethylaminobenzylidene) rhodanine chelates from food and water samples.

    PubMed

    Alothman, Zeid A; Al-Shaalan, Nora H; Habila, Mohamed A; Unsal, Yunus E; Tuzen, Mustafa; Soylak, Mustafa

    2015-02-01

    A dispersive liquid-liquid microextraction procedure for lead(II) as its 5-(4-dimethylaminobenzylidene) rhodanine complex has been established prior to its microsampling flame atomic absorption spectrometric determination. The influences of various analytical parameters including pH, solvent type and volume, dispersive solvent type and volume, 5-(4-dimethylaminobenzylidene) rhodanine amount, salt effect, and centrifugation time and speed were investigated. The effects of certain alkali, alkaline earth, and transition metal ions on the quantitative extraction of lead(II) were also studied. Quantitative recoveries were obtained at pH 6. The enrichment factor was calculated as 125. The detection limit for lead is 1.1 μg/L. The accuracy of the method was tested with the additions recovery test and analysis of the standard reference materials (SPS-WW2 waste water, NIST SRM 1515 apple leaves, and TMDA-51.3 fortified water). Applications of the present procedure were tested by analyzing water and food samples. PMID:25618567

  3. 3'-hydroxy-3,4,5,4'-tetramethoxystilbene, the metabolite of resveratrol analogue DMU-212, inhibits ovarian cancer cell growth in vitro and in a mice xenograft model.

    PubMed

    Piotrowska-Kempisty, Hanna; Ruciński, Marcin; Borys, Sylwia; Kucińska, Małgorzata; Kaczmarek, Mariusz; Zawierucha, Piotr; Wierzchowski, Marcin; Łażewski, Dawid; Murias, Marek; Jodynis-Liebert, Jadwiga

    2016-01-01

    In screening studies, the cytotoxic activity of four metabolites of resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) against A-2780 and SKOV-3 ovarian cancer cells was investigated. The most active metabolite, 3'-hydroxy-3,4,5,4'-tetramethoxystilbene (DMU-214), was chosen for further studies. The cytotoxicity of DMU-214 was shown to be higher than that of the parent compound, DMU-212, in both cell lines tested. Since DMU-212 was supposed to undergo metabolic activation through its conversion to DMU-214, an attempt was made to elucidate the mechanism of its anti-proliferative activity. We found that in SKOV-3 cells lacking p53, DMU-214 induced receptor-mediated apoptosis. In A-2780 cell line with expression of wild-type p53, DMU-214 modulated the expression pattern of p53-target genes driving intrinsic and extrinsic apoptosis pathways, as well as DNA repair and damage prevention. Regardless of the up-regulation of p48, p53R2, sestrins and Gaad45 genes involved in cancer cell DNA repair, we demonstrated the stronger anti-proliferative and pro-apoptotic effects of DMU-214 in A-2780 cells when compared to those in SKOV-3. Hence we verified DMU-214 activity in the xenograft model using SCID mice injected with A-2780 cells. The strong anti-proliferative activity of DMU-214 in the in vivo model allowed to suggest the tested compound as a potential therapeutic in ovarian cancer treatment. PMID:27585955

  4. Synthesis and antidepressant activities of 4-(substituted-phenyl)tetrazolo[1,5-a]quinazolin-5(4H)-ones and their derivatives.

    PubMed

    Zhang, Hong-Jian; Wang, Shi-Ben; Quan, Zhe-Shan

    2015-11-01

    A series of novel 4-(substituted-phenyl) tetrazolo[1,5-a]quinazolin-5(4H)-ones (6a-x) and their derivatives with tetrazole and other heterocyclic substituents (7-14) were designed, synthesized, and evaluated for antidepressant activities in mice. Pharmacological tests showed that three compounds (6l, 6u, and 6v) at a dose of 50 mg/kg significantly reduced the immobility time in the forced swimming test. The most active compound was 4-(p-tolyl)tetrazolo[1,5-a]quinazolin-5(4H)-one (6v), which decreased the immobility time by 82.69 % at 50 mg/kg. Moreover, 6v did not affect spontaneous activity in the open-field test, and this effect was comparable to the antidepressant effect of fluoxetine. Noradrenaline (NE) and 5-hydroxytryptamine (5-HT) levels in the brains of mice in the test sample groups significantly increased at a dose of 50 mg/kg compared with that in the control group. The monoamine oxidase (MAO) level of all test groups was reduced, but this result was not significantly different between the groups. Therefore, we can infer that their underlying mechanisms may involve the regulation of brain monoamine neurotransmitter homeostasis, based on the detected content of NE, 5-HT, and MAO in mouse brain tissue. PMID:26251313

  5. Intercalative pyrimido[4',5':4,5]thieno(2,3-b)quinolines induce apoptosis in leukemic cells: a comparative study of methoxy and morpholino substitution.

    PubMed

    Shahabuddin, M S; Nambiar, Mridula; Advirao, Gopal M; Raghavan, Sathees C

    2011-10-01

    DNA intercalating molecules are promising anticancer agents. Polycyclic aromatic molecules such as ellipticine intercalate into double-stranded DNA and affect major physiological functions. In the present study, we have characterized two molecules with the same chemical backbone but different side chains, namely 8-methoxy pyrimido[4',5':4,5]thieno (2,3-b)quinoline-4(3H)-one (MPTQ) and 4-morpholino pyrimido[4',5':4,5]thieno(2,3-b)quinoline (morpho-PTQ) at the 8th and 4th position, respectively. Although both MPTQ and morpho-PTQ show similar biophysical properties with high DNA affinity, here we show that they differ in their biological activities. We find that MPTQ is many fold more potent than morpho-PTQ and is cytotoxic against different leukemic cell lines. IC(50) value of methoxy PTQ was estimated between 2-15 µM among the leukemic cells studied, while it was more than 200 µM when morpho-PTQ was used. Cell cycle analysis shows an increase in sub-G1 phase, without any particular cell cycle arrest. Annexin V staining in conjunction with comet assay and DNA fragmentation suggest that MPTQ induces cytotoxicity by activating apoptosis. Thus the observed low IC(50) value of MPTQ makes it a promising cancer chemotherapeutic agent. PMID:20424886

  6. Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis.

    PubMed

    Nam, Joon; Kim, Wooseong; Lee, Sunyoung; Jeong, Seongkeun; Yoo, Jin-Wook; Kim, Min-Soo; Jung, Yunjin

    2016-06-01

    Local anesthetics have beneficial effects on colitis. Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester (Dex-5-ESA), designed as a polymeric colon-specific prodrug liberating 5-ASA and benzocaine in the large intestine, was prepared and its therapeutic activity against colitis was evaluated using a TNBS-induced rat colitis model. Dex-5-ESA liberated 5-ASA and benzocaine in the cecal contents while (bio)chemically stable in the small intestinal contents and mucosa. Oral administration of Dex-5-ESA (equivalent to 10 mg 5-ASA/kg, twice a day) alleviated colonic injury and reduced MPO activity in the inflamed colon. In parallel, pro-inflammatory mediators, COX-2, iNOS and CINC-3, elevated by TNBS-induced colitis, were substantially diminished in the inflamed colon. Dex-5-ESA was much more effective for the treatment of colitis than 5-(4-ethoxycarbonylphenylazo)salicylic acid (5-ESA) that may not deliver benzocaine to the large intestine. Our data suggest that Dex-5-ESA is a polymeric colon-specific prodrug, liberating 5-ASA and benzocaine in the target site (large intestine), probably exerting anti-colitic effects by combined action of 5-ASA and benzocaine. PMID:26377354

  7. The 5-4-3-2-1 go! Brand to promote nutrition and physical activity: a case of positive behavior change but negative change in beliefs.

    PubMed

    Evans, W Douglas; Wallace, Jasmine; Snider, Jeremy

    2015-01-01

    In recent years, community-based obesity prevention programs have taken an ecological approach and addressed social determinants of obesity. The branded 5-4-3-2-1 Go! obesity prevention program aims to change obesity risk behaviors in low-income neighborhoods in Chicago with a multilevel approach. This study follows a previous evaluation, which showed 5-4-3-2-1 Go! exposure to be associated with increased fruit and vegetable consumption. The authors examined whether increased positive beliefs about fruit and vegetable consumption were associated with exposure to program messages. Exploratory factor analysis identified a fresh fruit/vegetable availability satisfaction factor. The authors compared outcome measures between baseline and follow-up samples and between exposure and control conditions. Multivariable logistic regression models were estimated to evaluate the effects of program exposure on changes in nutrition beliefs. The study found that participants' (n = 246) beliefs about fruit and vegetable consumption were negatively associated with exposure to the program and that demographic factors, social environment, and physical environment were strongly associated with beliefs about fruit and vegetable consumption. These findings merit further research and may indicate the environmental factors that are associated with attitude formation among those reached by obesity prevention interventions, especially when many participants live in neighborhoods lacking convenient fruit and vegetable shopping options. PMID:25794355

  8. The 2.1-, 5.4- and 5.7-kb transcripts of the IDS gene are generated by different polyadenylation signals.

    PubMed

    Cudry, S; Froissart, R; Bouton, O; Maire, I; Bozon, D

    1999-10-01

    Deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS) is responsible for mucopolysaccharidosis type II (OMIM 309900). The IDS gene (Xq28) has been completely sequenced (accession number L35485). Northern blot analysis of poly(A(+)) RNA from different tissues, hybridized with the total IDS cDNA, has revealed three major species of 2.1, 5.4 and 5.7 kb and one minor of 1.4 kb. The 1.4-kb mRNA has been previously described and we show that the three major IDS mRNA are the result of alternative polyadenylation site selection: a non-canonical ATTAAA signal at genomic position 23631 for the 2.1-kb mRNA, a AATAAA signal at position 27156 for the 5.4-kb mRNA and a AATAAA signal at position 27399 for the 5.7-kb mRNA. The different IDS mRNA encode for the same polypeptide and the most abundant transcripts have a long 3'-untranslated region (3'-UTR). The absence of obvious correlation between transcripts content and size, IDS protein amount and IDS activity in the four human fetal tissues tested suggests that it is IDS protein processing that may be regulated rather than IDS gene transcription. PMID:10500241

  9. The "FORM" Approach to Reading Forms.

    ERIC Educational Resources Information Center

    Sandel, Lenore

    The FORM approach is designed to help persons in the senior population with the task of filling out the forms or applications required for a myriad of societal and human needs. The acronym represents a four-part approach consisting of: Facing the issue; applying Overview; Rewriting headings as questions; and Matching information as appropriate…

  10. Study on ethyl groups with two different orientations in [N(C2H5)4]2CuBr4

    NASA Astrophysics Data System (ADS)

    Lim, Ae Ran

    2016-06-01

    The crystal structure and phase transition temperature of [N(C2H5)4]2CuBr4 are studied using X-ray diffraction and differential scanning calorimetry (DSC); measurements revealed a tetragonal structure and the two phase transition temperatures TC of 204 K and 255.5 K. The structural geometry near TC is discussed in terms of the chemical shifts for 1H magic angle spinning (MAS) nuclear magnetic resonance (NMR) and 13C cross-polarization (CP)/MAS NMR. The two inequivalent ethyl groups are distinguishable by the 13C NMR spectrum. The molecular motions are discussed in terms of the spin-lattice relaxation times T1ρ in the rotating frame for 1H MAS NMR and 13C CP/MAS NMR. The T1ρ results reveal that the ethyl groups undergo tumbling motion, and furthermore that the ethyl groups are highly mobile.

  11. Substituent and solvent effects on the UV/Vis absorption spectra of 5-(4-substituted arylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones

    NASA Astrophysics Data System (ADS)

    Ušćumlić, Gordana S.; Mijin, Dusanˇ Z. ˇ; Valentić, Nataša V.; Vajs, Vlatka V.; Sušić, Biljana M.

    2004-10-01

    Absorption spectra of ten 5-(4-substituted arylazo)-6-hydroxy-4-methyl-3-cyano-2-pyridones have been recorded in fifteen solvents in the range 200-600 nm. The substituents at the phenyl nucleus are as follows: OH, OCH 3, CH 3, C 2H 5, H, Cl, Br, I, COOH and NO 2. The effects of substituents on the absorption spectra of investigated compounds are interpreted by correlation of absorption frequencies with simple Hammett equation. The effects of solvent polarity and solvent/solute hydrogen bonding interactions are analyzed by means of linear solvation energy relationships concept proposed by Kamlet and Taft. The azo-hydrazone tuatomeric equilibration is found to depend upon substituents as well as on solvents.

  12. Design of the high-speed framing, FEC, and interleaving hardware used in a 5.4km free-space optical communication experiment

    NASA Astrophysics Data System (ADS)

    Greco, Joseph A.

    2009-08-01

    The forward error correction (FEC) and interleaver realizations used in a 5.4 km horizontal-path link experiment incorporated several unique elements that were specifically tailored to address turbulence-induced fading. To facilitate optimization studies, this hardware was designed to afford a high degree of flexibility in the FEC code structure and interleaver length. An essential aspect of this structure was the standards-compliant client interface, which provided seamless connectivity to fiber-based terrestrial networks. Through the use of an OTU1 (2.667 Gbaud) architecture with nonstandard interleaving, error-free transmission was achieved in the presence of strong scintillation that produced fade events that frequently exceeded 10 ms in duration. This work was sponsored by the Department of Defense, RRCO DDR&E, under Air Force Contract FA8721-05-C-0002. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the United States Government.

  13. Low-dimensional charge transport of the ferroic NH 2(C 2H 5) 4CoCl 2Br 2 nanocrystals

    NASA Astrophysics Data System (ADS)

    Tkaczyk, S. W.; Kityk, I. V.; Rudyk, V.; Kapustianyk, V.

    2010-06-01

    DC-conductivity of the nanocomposites consisting of ferroic nanocrystals NH 2(C 2H 5) 4CoCl 2Br 2 (TEA-CCB) incorporated into the polymer PMMA matrices is investigated. The investigations are performed for different number of nanocrystallite chromophores and thickness of the samples. The thickness of the nanocomposite films was varied within 0.44-0.48 μm. The measurements were done at different temperatures and different applied voltages. As a dominant mechanism thermoemission was considered, which is determined by temperature of the samples.. The gold electrodes were used as principle electrodes. The observed phenomena were explained within a framework of hopping between the trapping levels and possible contribution of self-trapped excitons.

  14. Measurement of the W boson helicity in top quark decays using 5.4 fb⁻¹ of pp̄ collision data

    DOE PAGESBeta

    Abazov, V. M.; Abbott, B.; Acharya, B. S.; Adams, M.; Adams, T.; Alexeev, G. D.; Alkhazov, G.; Alton, A.; Alverson, G.; Alves, G. A.; et al

    2011-02-18

    We present a measurement of the helicity of the W boson produced in top quark decays using tt¯ decays in the l+jets and dilepton final states selected from a sample of 5.4 fb⁻¹ of collisions recorded using the D0 detector at the Fermilab Tevatron pp̄ collider. We measure the fractions of longitudinal and right-handed W bosons to be f₀=0.669±0.102[±0.078(stat.)±0.065(syst.)] and f₊=0.023±0.053[±0.041(stat.)±0.034(syst.)], respectively. This result is consistent at the 98% level with the standard model. A measurement with f₀ fixed to the value from the standard model yields f₊=0.010±0.037[±0.022(stat.)±0.030(syst.)].

  15. Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases.

    PubMed

    Hédou, Damien; Godeau, Julien; Loaëc, Nadège; Meijer, Laurent; Fruit, Corinne; Besson, Thierry

    2016-01-01

    A library of thirty novel thiazolo[5,4-f]quinazolin-9(8H)-one derivatives belonging to four series designated as 12, 13, 14 and 15 was efficiently prepared, helped by microwave-assisted technology when required. The efficient multistep synthesis of methyl 6-amino-2-cyano- benzo[d]thiazole-7-carboxylate (1) has been reinvestigated and performed on a multigram scale. The inhibitory potency of the final products against five kinases involved in Alzheimer's disease was evaluated. This study demonstrates that some molecules of the 12 and 13 series described in this paper are particularly promising for the development of new multi-target inhibitors of kinases. PMID:27144552

  16. Dysprosium thiogallate laser: source of mid-infrared radiation at 2.4, 4.3, and 5.4 µm

    NASA Astrophysics Data System (ADS)

    Jelinkova, H.; Doroshenko, M. E.; Osiko, V. V.; Jelínek, M.; Šulc, J.; Němec, M.; Vyhlídal, D.; Badikov, V. V.; Badikov, D. V.

    2016-08-01

    Various Dy:PbGa2S4 laser-active material energy transitions originating from the 6H9/2 + 6F11/2 or 6H11/2 energy level were investigated, and the mid-infrared radiation generation has been demonstrated. The Dy:PbGa2S4 laser was pumped by a 1.32-µm free-running Nd:YAG laser or laser diode radiation corresponding to the Dy:PbGa2S4 absorption peak. The Dy:PbGa2S4 crystal was placed in the stable optical resonator with the mirrors chosen according to the required generated wavelength. New laser wavelengths of 2.4 and 5.4 µm were generated from the Dy:PbGa2S4 laser at room temperature. Laser output characteristics at 4.3 µm are also presented.

  17. Identification and functional characterization of a putative IDE, C28F5.4 (ceIDE-1), in Caenorhabditis elegans: Implications for Alzheimer's disease.

    PubMed

    Haque, Rizwanul; Nazir, Aamir

    2016-11-01

    Insulin-degrading enzyme (IDE) is a zinc metalloprotease, known to degrade insulin peptide and amyloid-beta (Aβ); the key protein involved in Alzheimer's disease (AD). Considering the important role played by IDE in disease progression of AD and type 2 diabetes mellitus (T2DM), we endeavored to identify the Caenorhabditis elegans (C. elegans) IDE orthologous genes and test them for their role in AD related outcomes. We employed bioinformatics, reverse genetics and molecular biology approaches towards identification and functional characterization of putative IDE candidates in C. elegans. Using in-silico analysis we have identified seven C. elegans genes that possess HXXEH motif, an identifying marker of IDE. We further carried out functional analysis of the identified genes in Aβ expressing C. elegans strain CL4176 [myo-3/Aβ1-42 long 3'-UTR] via studying effect on Aβ induced toxicity, cholinergic neuroanatomy, content of acetylcholine/acetylcholine-esterase, extent of reactive oxygen species and expression of FOXO transcription factor DAF-16. Our findings reveal that amongst the identified putative IDE orthologs, a functionally uncharacterized gene C28F5.4 had a profound effect on the tested endpoints. Knocking down C28F5.4 modulated the AD associated conditions by decreasing Aβ induced toxicity, severely compromising cholinergic neuroanatomy, reducing expression of acetylcholine-transporter, decreasing acetylcholine content, elevating ROS, with no effect on DAF-16 stress-response protein. These studies provide crucial insight into the structural/functional orthology of IDEs across human and nematode species and further our understanding of the involvement of these proteins and insulin pathway in AD. Further studies could aid in identifying novel drug-targets and in understanding the common modulating factors between AD and T2DM. PMID:27443962

  18. Form 5-Mining venture agreement model form

    SciTech Connect

    Not Available

    1984-01-01

    This text acts as a reference of the basic terms and conditions for a negotiated mining venture agreement. Alternative clauses and provisions, along with extensive commentary, are supplied. The model form contains many articles which define and detail the process.

  19. Handbook of Poetic Forms.

    ERIC Educational Resources Information Center

    Padgett, Ron, Ed.

    Intended for secondary teachers and student writers but useful for anyone interested in poetic forms, this book defines 74 basic poetic forms, summarizes their histories, quotes examples from noted poets, and offers professional tricks of the trade on how to use each form. The book covers the following poetic forms: abstract poem, acrostic,…

  20. Bacteria form tellurium nanocrystals

    USGS Publications Warehouse

    Oremland, R.S.

    2007-01-01

    A team of researchers have found two bacterial species that produce tellurium oxyanions as respiratory electron acceptors for growth, leaving elemental tellurium in the form of nanoparticles. The crystals from the two organisms exhibit distinctively different structures. Bacillus selenitireducens initially forms nanorods that cluster together to form rosettes. Sulfurospirillum barnesii forms irregularly-shaped nanospheres that coalesce into larger composite aggregates.

  1. Synthesis, spectroscopic characterization, calculational studies and in vitro antitumoral activity of 4-(3-(1H-imidazol-1-yl)propyl)-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-5(4H)-one

    NASA Astrophysics Data System (ADS)

    Süleymanoğlu, Nevin; Ustabaş, Reşat; Alpaslan, Yelda Bingöl; Ünver, Yasemin; Turan, Mustafa; Sancak, Kemal

    2011-03-01

    4-(3-(1H-imidazol-1-yl)propyl)-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-5(4H)-one (IPTT), C 13H 15N 5OS, was synthesized and characterized by 13C NMR, 1H NMR, IR and single-crystal X-ray diffraction. The structure of IPTT is stabilized by three intermolecular hydrogen bonds and by intermolecular C sbnd H⋯ π interaction. The compound IPTT was modelled by using DFT method. Calculations of vibrational frequencies, gauge including atomic orbital (GIAO), 1H and 13C NMR chemical shifts of IPTT in the ground state, total electronic charge density map and frontier molecular orbitals were performed at B3LYP/6-31 G(d) level of theory were carried out by using DFT method with 6-31 G(d) basis set. The structural parameters obtained by geometry optimization, the theoretical vibrational frequencies and chemical shift values are in good agreement with experimental ones. FT-IR, NMR and X-ray analytical results of IPTT show that the compound exists as keto form, that was supported by DFT calculations. In addition, in vitro studies showed hopeful antitumoral activity of the title IPTT compound.

  2. Vibrational and structural observations and molecular docking study on 1-{3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazol-1-yl}-ethanone

    NASA Astrophysics Data System (ADS)

    Parveen S, Shana; Al-Alshaikh, Monirah A.; Panicker, C. Yohannan; El-Emam, Ali A.; Narayana, B.; Saliyan, Vinutha V.; Sarojini, B. K.; Van Alsenoy, C.

    2016-05-01

    A combined experimental and theoretical analysis of on molecular structure, vibrational spectra and HOMO-LUMO analysis of 1-{3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazol-1-yl}-ethanone is reported. The equilibrium geometry and vibrational wavenumbers have been computed using desnity functional B3LYP method with 6-311++G(d) (5D, 7F) as basis set. The nonlinear optical properties were evaluated by the determination of the first and second hyperpolarizabilities of the title compound. HOMO is localized over the whole molecule except the ring PhIII and the CH3 groups attached to the PhIII while the LUMO is located through out the whole molecule except the CH3 groups attached with the PhIII and this shows that an eventual charge transfer occurs within the molecule. From the molecular electrostatic potential study, the negative electrostatic potential regions are mainly localized over the carbonyl group, phenyl rings and are possible sites for electrophilic attack and the positive regions are localized over the nitrogen atoms as possible sites for nucleophilic attack. The docked ligand title compound forms a stable complex with kinesin spindle protein (KSP) and gives a binding affinity value of -6.7 kcal/mol the results suggest that the compound might exhibit inhibitory activity against KSP.

  3. Crystal structure of (Z)-1-(3,4-dichlorophenyl)-3-methyl-4-[(naphthalen-1-yl-amino)(p-tolyl)methylidene]-1H-pyrazol-5(4H)-one.

    PubMed

    Sharma, Naresh; Parihar, Sanjay; Jadeja, R N; Kant, Rajni; Gupta, Vivek K

    2014-09-01

    The title Schiff base compound, C28H21Cl2N3O, was synthesized by the condensation of 1-(3,4-di-chloro-phen-yl)-3-methyl-4-(4-methyl-benzo-yl)-1H-pyrazol-5(4H)-one with 1-aminona-phthalene. The p-tolyl ring is normal to the pyrazole ring, with a dihedral angle of 88.02 (14)°, and inclined to the naphthalene ring system by 78.60 (12)°. The pyrazole ring is inclined to the naphthalene ring system and the di-chloro-substituted benzene ring by 63.30 (12) and 11.03 (13)°, respectively. The amino group and carbonyl oxygen atom are involved in an intra-molecular N-H⋯O hydrogen bond enclosing an S(6) ring motif. There is also a short C-H⋯O contact involving the carbonyl O atom and the adjacent benzene ring. In the crystal, mol-ecules are linked by C-H⋯π inter-actions, forming a three-dimensional structure. PMID:25309277

  4. Solid-State Synthesis and Structure of the Enigmatic Ammonium Octaborate: (NH4)2[B7O9(OH)5]·3/4B(OH)3·5/4H2O.

    PubMed

    Neiner, Doinita; Sevryugina, Yulia V; Schubert, David M

    2016-09-01

    The compound known since the 19th century as ammonium octaborate was structurally characterized revealing the ammonium salt of the ribbon isomer of the heptaborate anion, [B7O9(OH)5](2-), with boric acid and water molecules. Of composition (NH4)2B7.75O12.63·4.88H2O, it approximates the classical ammonium octaborate composition (NH4)2B8O13·6H2O and has the structural formula {(NH4)2[B7O9(OH)5]}4·3B(OH)3·5H2O. It spontaneously forms at room temperature in solid-state mixtures of ammonium tetraborate and ammonium pentaborate. It crystallizes in the monoclinic space group P21/c with a = 11.4137(2) Å, b = 11.8877(2) Å, c = 23.4459(3) Å, β = 90.092(1)°, V = 3181.19(8) Å(3), and Z = 2 and contains well-ordered ammonium cations and [B7O9(OH)5](2-) anions and disordered B(OH)3 and H2O molecules linked by extensive H bonding. Expeditious solid-state formation of the heptaborate anion under ambient conditions has important implications for development of practical syntheses of industrially useful borates. PMID:27513178

  5. Synthesis, spectral (FT-IR, UV-visible, NMR) features, biological activity prediction and theoretical studies of 4-Amino-3-(4-hydroxybenzyl)-1H-1,2,4-triazole-5(4H)-thione and its tautomer

    NASA Astrophysics Data System (ADS)

    Srivastava, Ambrish Kumar; Kumar, Abhishek; Misra, Neeraj; Manjula, P. S.; Sarojini, B. K.; Narayana, B.

    2016-03-01

    Triazole compounds constitute an important class of organic chemistry due to their various biological and corrosion inhibition activities. The synthesis scheme of a new triazole compound namely, 4-Amino-3-(4-hydroxybenzyl)-1H-1,2,4-triazole-5(4H)-thione (4AHT) has been theoretically analyzed. Our density functional theory (DFT) based calculations show that the synthesis of 4AHT is energetically feasible at the room temperature as the reaction is exothermic, spontaneous as well as favored in forward direction. The calculated bond-lengths are found to be in good agreement with corresponding crystallographic values. We have considered two possible tautomers of 4AHT viz. thione and thiol forms. The FT-IR (KBr disc), UV-visible (ethanol) and 1H-NMR (DMSO) spectra of 4AHT have been recorded. The vibrational modes have been assigned on the basis of their potential energy distributions and scaled wavenumbers agree well with the FT-IR wavenumbers. Time dependent DFT calculations are performed to analyze the electronic transitions for various excited states which reproduce the experimental peak observed in UV-visible spectrum. Using gauge independent atomic orbital method 1H-NMR chemical shifts have been calculated and correlated with the experimental chemical shifts with the linear correlation coefficient of 0.9453. Our spectral analyses reveal the dominance of thione over thiol form of 4AHT. The chemical reactivity of 4AHT has been discussed by molecular electrostatic potential surface as well as various electronic parameters. The biological activities of 4AHT have also been explored theoretically and it has been found that the title molecule can act as a potential inhibitor of cyclin-dependent kinase 5 enzyme. These findings may guide the synthesis and design of new triazole compounds with interesting biological activity.

  6. Forms of Arthritis

    MedlinePlus

    ... this page please turn Javascript on. Forms of Arthritis Past Issues / Fall 2006 Table of Contents Today, ... of Linda Saisselin Osteoarthritis (OA) — the form of arthritis typically occurring during middle or old age, this ...

  7. Forms of Arthritis

    MedlinePlus

    ... stiffness, inflammation, swelling and, sometimes, destruction of joints. Gout — a form of arthritis that occurs when uric ... the joints. Some 2.1 million Americans have gout. Lupus — a form of arthritis, like rheumatoid arthritis, ...

  8. TSG (2,3,5,4'-Tetrahydroxystilbene-2-O- β -D-glucoside) from the Chinese Herb Polygonum multiflorum Increases Life Span and Stress Resistance of Caenorhabditis elegans.

    PubMed

    Büchter, Christian; Zhao, Liang; Havermann, Susannah; Honnen, Sebastian; Fritz, Gerhard; Proksch, Peter; Wätjen, Wim

    2015-01-01

    2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) was isolated from Polygonum multiflorum, a plant which is traditionally used as an anti-ageing drug. We have analysed ageing-related effects of TSG in the model organism C. elegans in comparison to resveratrol. TSG exerted a high antioxidative capacity both in a cell-free assay and in the nematode. The antioxidative capacity was even higher compared to resveratrol. Presumably due to its antioxidative effects, treatment with TSG decreased the juglone-mediated induction of the antioxidative enzyme SOD-3; the induction of the GST-4 by juglone was diminished slightly. TSG increased the resistance of C. elegans against lethal thermal stress more prominently than resveratrol (50 μM TSG increased mean survival by 22.2%). The level of the ageing pigment lipofuscin was decreased after incubation with the compound. TSG prolongs the mean, median, and maximum adult life span of C. elegans by 23.5%, 29.4%, and 7.2%, respectively, comparable to the effects of resveratrol. TSG-mediated extension of life span was not abolished in a DAF-16 loss-of-function mutant strain showing that this ageing-related transcription factor is not involved in the effects of TSG. Our data show that TSG possesses a potent antioxidative capacity, enhances the stress resistance, and increases the life span of the nematode C. elegans. PMID:26075030

  9. Measurement of electron-impact excitation into the 3p{sup 5}4p levels of argon using Fourier-transform spectroscopy

    SciTech Connect

    Chilton, J.E.; Boffard, J.B.; Schappe, R.S.; Lin, C.C.

    1998-01-01

    To experimentally determine electron-impact excitation cross sections with the optical method, it is necessary to measure all transitions out of a level (the {ital apparent} cross sections), as well as the cascades into the level. In the case of the ten 3p{sup 5}4p levels of argon, the emissions to lower levels lie in the visible and near infrared (660{endash}1150 nm) and are hence observable with a monochromator{endash}photomultiplier-tube (PMT) system. A Fourier-transform spectrometer (FTS) allows us to measure the previously uninvestigated cascades that lie in the infrared. For the incident electron energy range between onset and 300 eV, we have measured the apparent cross sections with a monochromator-PMT system, and the cascade cross sections with a weak emission FTS system. The magnitude of both the apparent and cascade cross sections increases with target gas pressure due to radiation trapping effects. By subtracting the cascade contributions from the apparent cross sections, we have determined the direct cross sections and verified that they do not vary with pressure in the 0.5{endash}4-mTorr pressure range considered here. {copyright} {ital 1998} {ital The American Physical Society}

  10. 3,5,4′-Tri-O-acetylresveratrol Attenuates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome via MAPK/SIRT1 Pathway

    PubMed Central

    Ma, Lijie; Zhao, Yilin; Wang, Ruixuan; Chen, Tingting; Li, Wangping; Nan, Yandong; Liu, Xueying; Jin, Faguang

    2015-01-01

    The aim of the present research was to investigate the protecting effects of 3,5,4′-tri-O-acetylresveratrol (AC-Rsv) on LPS-induced acute respiratory distress syndrome (ARDS). Lung injuries have been evaluated by histological examination, wet-to-dry weight ratios, and cell count and protein content in bronchoalveolar lavage fluid. Inflammation was assessed by MPO activities and cytokine secretion in lungs and cells. The results showed that AC-Rsv significantly reduced the mortality of mice stimulated with LPS. Pretreatment of AC-Rsv attenuated LPS-induced histological changes, alleviated pulmonary edema, reduced blood vascular leakage, and inhibited the MPO activities in lungs. What was more, AC-Rsv and Rsv treatment reduced the secretion of TNF-α, IL-6, and IL-1β in lungs and NR8383 cells, respectively. Further exploration revealed that AC-Rsv and Rsv treatment relieved LPS-induced inhibition on SIRT1 expression and restrained the activation effects of LPS on MAPKs and NF-κB activation both in vitro and in vivo. More importantly, in vivo results have also demonstrated that the protecting effects of Rsv on LPS-induced inflammation would be neutralized when SIRT1 was in-hibited by EX527. Taken together, these results indicated that AC-Rsv protected lung tissue against LPS-induced ARDS by attenuating inflammation via p38 MAPK/SIRT1 pathway. PMID:26648661

  11. Use of vibrational spectroscopy to study 2-[4-(N-dodecanoylamino)phenyl]-5-(4-nitrophenyl)-1,3,4-oxadiazole: a combined theoretical and experimental approach.

    PubMed

    Bee, Saba; Agarwal, Parag; Gupta, Archana; Tandon, Poonam

    2013-10-01

    Quantum chemical calculations of geometric structure and vibrational wavenumbers of 2-[4-(N-dodecanoylamino)phenyl]-5-(4-nitrophenyl)-1,3,4-oxadiazole (AF51) were carried out by using density functional theory (DFT/B3LYP/6-311G(d,p) method. The fundamental vibrational modes were characterized depending on their potential energy distribution (PED). In order to predict the reactive sites for electrophilic and nucleophilic attacks of the title molecule, electrostatic potential surface has been plotted. The UV absorption spectrum was examined in chloroform solvent and compared with the calculated one in gas phase as well as in solvent environment using TD-DFT/ PCM approach. The (1)H NMR spectra was recorded. Comparison between the experimental and the theoretical results is satisfactory. The thermodynamic properties of the title compound at different temperatures have been calculated. A relationship between molecular structural features, non-linear responses and hyperpolarizability of AF51 has been established using vibrational spectra with emphasis on the role of intramolecular charge transfer mechanism in such organic NLO materials. PMID:23770512

  12. Hydrogen bonding and coordination bonding in the electronically excited states of Cu2(L)2 (L = 5-(4-pyridyl)tetrazole)MeOH: A TDDFT study

    NASA Astrophysics Data System (ADS)

    Meng, Yanfang; Zhang, Chunqing; Ji, Min; Hao, Ce; Qiu, Jieshan

    2013-05-01

    The luminescent metal organic framework (MOF), Cu2(L)2·MeOH (L = 5-(4-pyridyl)tetrazole), was studied using time-dependent density functional theory (TDDFT). A combination of frontier molecular orbitals and electronic configuration analysis revealed that the emission mechanism was a ligand to metal charge transition (LMCT) rather than a metal to ligand charge transfer (MLCT). Hydrogen bonding significantly changed the nature of the frontier orbital and the luminescence. Electronic transition energies predicted that the hydrogen bonding in excited state would become weaker with an electronic spectral blue-shift. The bond lengths, frequencies, and binding energies indicated weakening of the hydrogen bonding in the excited state, which can affect emissions in two ways, including: (i) a decrease in the electronic coupling between methanol and the motif and suppressing the occurrence of the photo-induced electron transfer (PET); and (ii) increasing the energy gap between S1 and S0, leading to radiative transition. Coordination bonding was also investigated in the excited state through bond lengths, frequencies, and bond orders. Coordination bonds were found to become stronger in the excited state leading to an enhancement of the luminescence.

  13. A Snapshot Survey for Gravitational Lenses among z>=4.0 Quasars. II. Constraints on the 4.05.4 Quasar Population

    NASA Astrophysics Data System (ADS)

    Richards, Gordon T.; Haiman, Zoltán; Pindor, Bartosz; Strauss, Michael A.; Fan, Xiaohui; Eisenstein, Daniel; Schneider, Donald P.; Bahcall, Neta A.; Brinkmann, J.; Fukugita, Masataka

    2006-01-01

    We report on i-band snapshot observations of 157 Sloan Digital Sky Survey quasars at 4.05.4 using the Advanced Camera for Surveys on the Hubble Space Telescope (HST) to search for evidence of gravitational lensing of these sources. None of the quasars appear to be strongly lensed and multiply imaged at the angular resolution (~0.1") and sensitivity of HST. The nondetection of strong lensing in these systems constrains the z=4-5 luminosity function to an intrinsic slope of β>-3.8 (3 σ), assuming a break in the quasar luminosity function at M*1450~-24.5. This constraint is considerably stronger than the limit of β>-4.63 obtained from the absence of lensing in four z>5.7 quasars. Such constraints are important to our understanding of the true space density of high-redshift quasars and the ionization state of the early universe. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555. These observations are associated with program 9472.

  14. 5-4-3-2-1 go! Coordinating pediatric resident education and community health promotion to address the obesity epidemic in children and youth.

    PubMed

    Stahl, Christiane Ellen; Necheles, Jonathan Wolf; Mayefsky, Jay Hirsh; Wright, Lydia Katherine; Rankin, Kristin Michele

    2011-03-01

    This study investigated the feasibility and effectiveness of training pediatric residents to conduct a brief clinic-based behavioral intervention in coordination with community dissemination of a health promotion message developed by the Consortium for Lowering Obesity in Chicago Children. A total of 113 residents completed a short (<60 minutes) online training program. Some (64) residents distributed interview contact cards to patients they saw in their continuity of care clinics after training; others (45) distributed cards before training. A researcher interviewed 75% of the 509 patients 4 weeks after the visit. More patients of trained residents reported positive changes in behaviors which have been associated with lower obesity rates: increased intake of fruits and vegetables (28% vs 16%, P < .01), increased intake of water (30% vs 19%, P < .01), increased physical activity (40% vs 29%, P < .03), and decreased television time (36% vs 24%, P < .01). Brief training using the 5-4-3-2-1-Go! message seems to be feasible and effective. PMID:21098524

  15. Aortic Remodelling Is Improved by 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside Involving the Smad3 Pathway in Spontaneously Hypertensive Rats

    PubMed Central

    Duan, Ju; Han, Xin; Ling, Shuang; Gan, Woting; Sun, Li; Ni, Rong-Zhen; Xu, Jin-Wen

    2015-01-01

    Hypertension is a common health problem that substantially increases the risk of cardiovascular disease. The condition increases blood pressure, which causes alterations in vascular structure and leads to the development of vascular pathologies. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG), a resveratrol analogue extracted from a Chinese medicinal plant, has been proven to have numerous vascular protection functions. This study investigated whether THSG can improve vascular remodeling, which has thus far remained unclear. Orally administering THSG to spontaneously hypertensive rats (SHRs) aged 12 weeks for 14 weeks significantly inhibited intima-media thickness in the lower parts of the aortic arch, increased the vascular diastolic rate in response to acetylcholine, and reduced remodelling-related mRNA expression, such as that of ACTA2, CCL3, COL1A2, COL3A1, TIMP1 WISP2, IGFBP1, ECE1, KLF5, MYL1 BMP4, FN1, and PAI-1. Immunofluorescence staining also showed an inhibitory effect similar to that of THSG on PAI-1 protein expression in rat aortas. Results from immunoprecipitation and a Western blot assay showed that THSG inhibited the acetylation of Smad3. A chromatin immunoprecipitation assay showed that THSG prevented Smad3 binding to the PAI-1 proximal promoter in SHR aortas. In conclusion, our results demonstrated that the inhibitory effect of THSG on aortic remodelling involved the deacetylating role of Smad3 with increasing blood flow and with constant blood pressure. PMID:26693246

  16. Electrical properties and conduction mechanism of [N(C2H5)4][N(CH3)4]CuCl4 compound

    NASA Astrophysics Data System (ADS)

    Drissi, N.; Karoui, K.; Jomni, F.; Rhaiem, A. Ben

    2016-09-01

    The [N(CH3)4][N(C2H5)4]CuCl4 single crystal has been synthetized in order to determinate the temperatures transition and to study the electrical properties and the conduction mechanism. At room temperature, this compound crystallizes in the tetragonal system with P-421m space group. The calorimetric study shows three anomalies at 248, 284 and 326 K. Electrical conduction and dielectrical relaxation mechanisms at various frequencies and temperatures were analyzed by impedance spectroscopy and the equivalent circuit based on the Z-View-software was proposed. The variation of fp relaxation determinate by the modulus study and σdc specific to the AC conductivity as a function of temperature and confirm the all transitions for our sample. The values of the activation energy are determined and compared by those, which are found in the similar compound. Frequencies dependence of alternative current (AC) conductivity is interpreted in terms of Jonscher's law and the conduction mechanisms for each phase are determined with the Elliot's theory.

  17. Pulsed laser operating on the first vibrational overtone of the CO molecule in the 2.5-4.2-{mu}m range: 1. Multifrequency lasing

    SciTech Connect

    Basov, N G; Ionin, Andrei A; Kotkov, A A; Seleznev, L V; Kurnosov, A K; Napartovich, A P; Turkin, N G; McCord, J E; Hager, G D

    2000-09-30

    Characteristics of a pulsed, multifrequency electroionisation CO laser operating on the first vibrational overtone of the CO molecule are studied experimentally and theoretically. It is shown experimentally that a pulsed, multifrequency overtone CO laser is an efficient source of coherent radiation in the 2.5-4.1-{mu}m region whose specific output reaches 50 J l{sup -1} amagat{sup -1} and the electro-optical efficiency amounts to 11 %. A theoretical analysis based on experimental data shows the feasibility of obtaining overtone emission with efficiency as high as {approx}20 %. The alternation of the intensity of vibrational bands in the overtone CO laser is discussed. This effect is caused by the cascade mechanism of formation of the emission spectrum. The comparison of experimental data with calculations showed that they agree well with respect to spectral and energy characteristics of the overtone CO laser. Moreover, it revealed the necessity of refinement of the kinetic model of the active medium of the CO laser for obtaining an adequate description of time parameters of a laser pulse. (lasers)

  18. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-glucoside Isolated from Polygoni Multiflori Ameliorates the Development of Periodontitis

    PubMed Central

    Chin, Yu-Tang; Hsieh, Meng-Ti; Lin, Chi-Yu; Kuo, Po-Jan; Yang, Yu-Chen S. H.; Shih, Ya-Jung; Lai, Hsuan-Yu; Cheng, Guei-Yun; Tang, Heng-Yuan; Lee, Chen-Chen; Lee, Sheng-Yang; Wang, Ching-Chiung; Whang-Peng, Jacqueline; Liu, Leroy F.

    2016-01-01

    Periodontitis, a chronic infection by periodontopathic bacteria, induces uncontrolled inflammation, which leads to periodontal tissue destruction. 2,3,5,4′-Tetrahydroxystilbene-2-O-beta-glucoside (THSG), a polyphenol extracted from Polygoni Multiflori, reportedly has anti-inflammatory properties. In this study, we investigated the mechanisms of THSG on the Porphyromonas gingivalis-induced inflammatory responses in human gingival fibroblasts and animal modeling of ligature-induced periodontitis. Human gingival fibroblast cells were treated with lipopolysaccharide (LPS) extracted from P. gingivalis in the presence of resveratrol or THSG to analyze the expression of TNF-α, IL-1β, and IL-6 genes. Increased AMP-activated protein kinase (AMPK) activation and SirT1 expression were induced by THSG. Treatment of THSG decreased the expression of LPS-induced inflammatory cytokines, enhanced AMPK activation, and increased the expression of SirT1. In addition, it suppressed the activation of NF-κB when cells were stimulated with P. gingivalis LPS. The anti-inflammatory effect of THSG and P. Multiflori crude extracts was reproduced in ligature-induced periodontitis animal modeling. In conclusion, THSG inhibited the inflammatory responses of P. gingivalis-stimulated human gingival fibroblasts and ameliorated ligature-induced periodontitis in animal model. PMID:27504055

  19. 1,8-Di­aza­bicyclo­[5.4.0]undec-7-en-8-ium bromido­(phthalocyaninato)zincate

    PubMed Central

    Przybył, Bartosz; Janczak, Jan

    2014-01-01

    The title compound, (C9H17N2)[ZnBr(C32H16N8)], contains a bromido­(phthalocyaninato)zincate anion and a protonated 1,8-di­aza­bicyclo­[5.4.0]undece-7-ene cation, [DBUH]+. The central ZnII atom has a distorted square-pyramidal geometry, with four iso­indole N atoms of the macrocycle in equatorial positions and a bromide ion in the axial position. The latter has a relatively high displacement parameter, but no evidence for disorder was obtained. The central ZnII atom is displaced by 0.488 (3) Å from the mean plane defined by the four iso­indole N atoms. The [DBUH]+ cation is involved in an almost linear N—H⋯Br hydrogen bond. In the crystal, π–π inter­actions lead to a relatively short distance of 3.366 (3) Å between the phthalocyaninate rings. PMID:24940212

  20. Aortic Remodelling Is Improved by 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside Involving the Smad3 Pathway in Spontaneously Hypertensive Rats.

    PubMed

    Duan, Ju; Han, Xin; Ling, Shuang; Gan, Woting; Sun, Li; Ni, Rong-Zhen; Xu, Jin-Wen

    2015-01-01

    Hypertension is a common health problem that substantially increases the risk of cardiovascular disease. The condition increases blood pressure, which causes alterations in vascular structure and leads to the development of vascular pathologies. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG), a resveratrol analogue extracted from a Chinese medicinal plant, has been proven to have numerous vascular protection functions. This study investigated whether THSG can improve vascular remodeling, which has thus far remained unclear. Orally administering THSG to spontaneously hypertensive rats (SHRs) aged 12 weeks for 14 weeks significantly inhibited intima-media thickness in the lower parts of the aortic arch, increased the vascular diastolic rate in response to acetylcholine, and reduced remodelling-related mRNA expression, such as that of ACTA2, CCL3, COL1A2, COL3A1, TIMP1 WISP2, IGFBP1, ECE1, KLF5, MYL1 BMP4, FN1, and PAI-1. Immunofluorescence staining also showed an inhibitory effect similar to that of THSG on PAI-1 protein expression in rat aortas. Results from immunoprecipitation and a Western blot assay showed that THSG inhibited the acetylation of Smad3. A chromatin immunoprecipitation assay showed that THSG prevented Smad3 binding to the PAI-1 proximal promoter in SHR aortas. In conclusion, our results demonstrated that the inhibitory effect of THSG on aortic remodelling involved the deacetylating role of Smad3 with increasing blood flow and with constant blood pressure. PMID:26693246

  1. Study of the Activity of 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one against Schistosomiasis Mansoni in Mice

    PubMed Central

    da Silva, Andréa Cristina Apolinário; Neves, Juliana Kelle de Andrade Lemoine; Irmão, João Inácio; Costa, Vláudia Maria Assis; Souza, Valdênia Maria Oliveira; de Medeiros, Paloma Lys; da Silva, Eliete Cavalcanti; de Lima, Maria do Carmo Alves; Pitta, Ivan da Rocha; Albuquerque, Mônica Camelo Pessoa de Azevedo; Galdino, Suely Lins

    2012-01-01

    Previous studies conducted with the imidazolidinic derivative 3-benzyl-5-(4-chloro-arylazo)-4-thioxo-imidazolidin-2-one (LPSF-PT05) show outstanding activity against adult Schistosoma mansoni worms in vitro. In the first phase of this study, S. mansoni-infected mice were treated, orally, with 100 mg/Kg of the LPSF-PT05 in three formulations: Tween 80 and saline solution, oil/water (70 : 30) emulsion, and solid dispersion with polyethylene glycol (PEG). In the second phase, three other doses of the LPSF-PT05 in PEG were tested: 3, 10, 30 mg/kg. These treatment regimens significantly reduced the number of recovered worms due to increases in the solubility of the compound in this formulation; the greatest reduction (70.5%) was observed at the dose of 100 mg/kg. There was no changes in the pattern of mature egg compared to immature eggs; however there was a significant increase in the number of dead eggs. Histopathological analysis of liver tissue showed changes in morphological aspects of the hepatic parenchyma with decrease exudative-productive hepatic granuloma stages, although we found no significant differences in IFN-γ, IL-4, IL-10, or NO production in response to the specific antigen SEA. The results show the derivative LPSF-PT05 to be a potential candidate in the etiological treatment of schistosomiasis with a possible dampening effect of the granulomatous process. PMID:22623908

  2. Synthesis and Biological Screening of 5-{[(4,6-Disubstituted pyrimidine-2-yl)thio]methyl}-N-phenyl-1,3,4-thiadiazol-2-amines

    PubMed Central

    Azam, M. A.; Kumar, B. R. P.; Shalini, S.; Suresh, B.; Reddy, T. K.; Reddy, C. D.

    2008-01-01

    A number of substituted-α,β-unsaturated carbonyl compounds (1a-i) were prepared by Claisen-Schmidt condensation of substituted acetophenone with selected araldehydes, which on cycloaddition with thiourea furnished 4,6-disubstituted pyrimidine-2-thiols (2a-i). Reaction of (2a-i) with ethyl chloroacetate followed by condensation with hydrazine hydrate yielded 2-[(4,6-disubstituted pyrimidine-2-yl) thio] acetohydrazides (4a-c). Condensation of compounds (4a-c) with phenyl isothiocyanate gave 2-{[(4,6-disubstituted pyrimidine-2-yl) thio] acetyl}-N-phenylhydrazinecarbothioamides (5a-c) which on treatment with concentrated sulphuric acid afforded titled compounds 5-{(4,6-disubstituted pyrimidine-2-yl) thio] methyl}-N-phenyl-1,3,4-thiadiazole-2-amines (6a-c). These compounds have been characterized on the basis of elemental analysis, IR, 1H NMR and MS. Compounds have been evaluated for their anticancer and antioxidant activities. Compounds 2b, 2c and 6b exhibited significant antitumor activity against human breast cancer MCF 7 cell line. However, moderate antioxidant activity was observed with compounds 2c, 2d, 2g and 6b. PMID:21394274

  3. Electrical characterization of 5.4 MeV alpha-particle irradiated 4H-SiC with low doping density

    NASA Astrophysics Data System (ADS)

    Paradzah, A. T.; Auret, F. D.; Legodi, M. J.; Omotoso, E.; Diale, M.

    2015-09-01

    Nickel Schottky diodes were fabricated on 4H-SiC. The diodes had excellent current rectification with about ten orders of magnitude between -50 V and +2 V. The ideality factor was obtained as 1.05 which signifies the dominance of the thermionic emission process in charge transport across the barrier. Deep level transient spectroscopy revealed the presence of four deep level defects in the 30-350 K temperature range. The diodes were then irradiated with 5.4 MeV alpha particles up to fluence of 2.6 × 1010 cm-2. Current-voltage and capacitance-voltage measurements revealed degraded diode characteristics after irradiation. DLTS revealed the presence of three more energy levels with activation enthalpies of 0.42 eV, 0.62 eV and 0.76 eV below the conduction band. These levels were however only realized after annealing the irradiated sample at 200 °C and they annealed out at 400 °C. The defect depth concentration was determined for some of the observed defects.

  4. A novel DNA intercalator, butylamino-pyrimido[4',5':4,5]selenolo(2,3-b)quinoline, induces cell cycle arrest and apoptosis in leukemic cells.

    PubMed

    Shahabuddin, M S; Nambiar, Mridula; Choudhary, Bibha; Advirao, Gopal M; Raghavan, Sathees C

    2010-02-01

    DNA intercalators are one of the most commonly used chemotherapeutic agents. Novel intercalating compounds of pyrimido[4',5':4,5]selenolo(2,3-b)quinoline series having a butylamino or piperazino group at fourth position (BPSQ and PPSQ, respectively) are studied. Our results showed that BPSQ induced cytotoxicity whereas PPSQ was cytostatic. The cytotoxicity induced by BPSQ was concentration- and time-dependent. Cell cycle analysis and tritiated thymidine assay revealed that BPSQ affects the cell cycle progression by arresting at S phase. The absence of p-histone H3 and reduction in the levels of PCNA in the cells treated with BPSQ further confirmed the cell cycle arrest. Further, annexin V staining, DNA fragmentation, nuclear condensation and changes in the expression levels of BCL2/BAD confirmed the activation of apoptosis. Activation of caspase 8 and lack of cleavage of caspase 9, caspase 3 and PARP suggest the possibility of BPSQ triggering extrinsic pathway for induction of apoptosis, which is discussed. Hence, we have identified a novel compound which would have clinical relevance in cancer chemotherapeutics. PMID:19142583

  5. In-situ TEM on (de)hydrogenation of Pd at 0.5-4.5 bar hydrogen pressure and 20-400°C.

    PubMed

    Yokosawa, Tadahiro; Alan, Tuncay; Pandraud, Gregory; Dam, Bernard; Zandbergen, Henny

    2012-01-01

    We have developed a nanoreactor, sample holder and gas system for in-situ transmission electron microscopy (TEM) of hydrogen storage materials up to at least 4.5 bar. The MEMS-based nanoreactor has a microheater, two electron-transparent windows and a gas inlet and outlet. The holder contains various O-rings to have leak-tight connections with the nanoreactor. The system was tested with the (de)hydrogenation of Pd at pressures up to 4.5 bar. The Pd film consisted of islands being 15 nm thick and 50-500 nm wide. In electron diffraction mode we observed reproducibly a crystal lattice expansion and shrinkage owing to hydrogenation and dehydrogenation, respectively. In selected-area electron diffraction and bright/dark-field modes the (de)hydrogenation of individual Pd particles was followed. Some Pd islands are consistently hydrogenated faster than others. When thermally cycled, thermal hysteresis of about 10-16°C between hydrogen absorption and desorption was observed for hydrogen pressures of 0.5-4.5 bar. Experiments at 0.8 bar and 3.2 bar showed that the (de)hydrogenation temperature is not affected by the electron beam. This result shows that this is a fast method to investigate hydrogen storage materials with information at the nanometer scale. PMID:22088507

  6. Aftershock relocation and frequency-size distribution, stress inversion and seismotectonic setting of the 7 August 2013 M = 5.4 earthquake in Kallidromon Mountain, central Greece

    NASA Astrophysics Data System (ADS)

    Ganas, Athanassios; Karastathis, Vassilios; Moshou, Alexandra; Valkaniotis, Sotirios; Mouzakiotis, Evangelos; Papathanassiou, George

    2014-03-01

    On August 7, 2013 a moderate earthquake (NOA ML = 5.1, NOA Mw = 5.4) occurred in central Kallidromon Mountain, in the Pthiotis region of central Greece. 2270 aftershocks were relocated using a modified 1-D velocity model for this area. The b-value of the aftershock sequence was b = 0.85 for a completeness magnitude of Mc = 1.7. The rate of aftershock decay was determined at p = 0.63. The spatial distribution of the aftershock sequence points towards the reactivation of a N70° ± 10°E striking normal fault at crustal depths between 8 and 13 km. A NNW-SSE cross-section imaged the activation of a steep, south dipping normal fault. A stress inversion analysis of 12 focal mechanisms showed that the minimum horizontal stress is extensional at N173°E. No primary surface ruptures were observed in the field; however, the earthquake caused severe damage in the villages of the Kallidromon area. The imaged fault strike and the orientation of the long-axis of the aftershock sequence distribution are both at a high-angle to the strike of known active faults in this area of central Greece. We interpret the Kallidromon seismic sequence as release of extensional seismic strain on secondary, steep faults inside the Fokida-Viotia crustal block.

  7. Discovery of 2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid (SX-517): Noncompetitive Boronic Acid Antagonist of CXCR1 and CXCR2

    PubMed Central

    2015-01-01

    The G protein-coupled chemokine receptors CXCR1 and CXCR2 play key roles in inflammatory diseases and carcinogenesis. In inflammation, they activate and recruit polymorphonuclear cells (PMNs) through binding of the chemokines CXCL1 (CXCR1) and CXCL8 (CXCR1 and CXCR2). Structure–activity studies that examined the effect of a novel series of S-substituted 6-mercapto-N-phenyl-nicotinamides on CXCL1-stimulated Ca2+ flux in whole human PMNs led to the discovery of 2-[5-(4-fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic acid (SX-517), a potent noncompetitive boronic acid CXCR1/2 antagonist. SX-517 inhibited CXCL1-induced Ca2+ flux (IC50 = 38 nM) in human PMNs but had no effect on the Ca2+ flux induced by C5a, fMLF, or PAF. In recombinant HEK293 cells that stably expressed CXCR2, SX-517 antagonized CXCL8-induced [35S]GTPγS binding (IC50 = 60 nM) and ERK1/2 phosphorylation. Inhibition was noncompetitive, with SX-517 unable to compete the binding of [125I]-CXCL8 to CXCR2 membranes. SX-517 (0.2 mg/kg iv) significantly inhibited inflammation in an in vivo murine model. SX-517 is the first reported boronic acid chemokine antagonist and represents a novel pharmacophore for CXCR1/2 antagonism. PMID:25254640

  8. Forms in Space.

    ERIC Educational Resources Information Center

    Moore, Paula

    1998-01-01

    Uses the work of M. C. Escher to instruct upper elementary students in the transformation of flat shape into three-dimensional form. Outlines the lesson as a series of sections: (1) reviewing form drawing; (2) creating three-dimensional effects; (3) imagining the forms in an inhabited world; and (4) using color and shading. (DSK)

  9. Mesonic Form Factors

    SciTech Connect

    Frederic D. R. Bonnet; Robert G. Edwards; George T. Fleming; Randal Lewis; David Richards

    2003-07-22

    We have started a program to compute the electromagnetic form factors of mesons. We discuss the techniques used to compute the pion form factor and present preliminary results computed with domain wall valence fermions on MILC asqtad lattices, as well as Wilson fermions on quenched lattices. These methods can easily be extended to rho-to-gamma-pi transition form factors.

  10. Method for forming ammonia

    DOEpatents

    Kong, Peter C.; Pink, Robert J.; Zuck, Larry D.

    2008-08-19

    A method for forming ammonia is disclosed and which includes the steps of forming a plasma; providing a source of metal particles, and supplying the metal particles to the plasma to form metal nitride particles; and providing a substance, and reacting the metal nitride particles with the substance to produce ammonia, and an oxide byproduct.

  11. 2,4-Diamino-5-(4-chloro­phen­yl)-6-ethyl­pyrimidin-1-ium 2-propanamido­benzoate

    PubMed Central

    Natarajan, Sampath; Mathews, Rita

    2011-01-01

    In the title salt, C12H14ClN4 +·C10H10NO3 −, zwitterionic N—H⋯O inter­actions form an R 2 2(8) ring. The crystal structure is stabilized by N—H⋯O and N—H⋯N hydrogen bonds involving two different eight-membered rings. An N—H⋯O inter­action occurs between the pyrimidine ring (donor) and carboxyl­ate group (acceptor) while the other ring is formed by N—H⋯N inter­actions, which form a dimer between two symmetry-related salts. An intra­molecular N—H⋯O hydrogen bond forms a six-membered ring in the benzoate. Inter­molecular C—H⋯O inter­actions are also observed. PMID:22065507

  12. 2,4-Diamino-5-(4-chloro­phen­yl)-6-ethyl­pyrimidin-1-ium 2-acet­amido­benzoate

    PubMed Central

    Natarajan, Sampath; Mathews, Rita

    2011-01-01

    The title compound, C12H14ClN4 +·C9H8NO3 −, is a salt with a 1:1 ratio of cation and anion components inter­acting with each other forming an R 2 2(8) ring motif. The crystal structure is stabilized by hydrogen bonds (N—H⋯O) involving two different eight-membered rings. One of them is formed between the pyrimidine ring (donor) and the carboxylate group (acceptor) from the benzoate, whereas the other ring is formed by N—H⋯O interactions, which help to form a dimer between two symmetry-related salts in the unit cell. In addition, an intramolecular C—H⋯N and intermolecular C—H⋯Cl interactions help to control the molecules in the unit-cell packing. PMID:22065484

  13. Methods of forming steel

    DOEpatents

    Branagan, Daniel J.; Burch, Joseph V.

    2001-01-01

    In one aspect, the invention encompasses a method of forming a steel. A metallic glass is formed and at least a portion of the glass is converted to a crystalline steel material having a nanocrystalline scale grain size. In another aspect, the invention encompasses another method of forming a steel. A molten alloy is formed and cooled the alloy at a rate which forms a metallic glass. The metallic glass is devitrified to convert the glass to a crystalline steel material having a nanocrystalline scale grain size. In yet another aspect, the invention encompasses another method of forming a steel. A first metallic glass steel substrate is provided, and a molten alloy is formed over the first metallic glass steel substrate to heat and devitrify at least some of the underlying metallic glass of the substrate.

  14. (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression.

    PubMed

    Nguyen, Charles B; Kotturi, Hari; Waris, Gulam; Mohammed, Altaf; Chandrakesan, Parthasarathy; May, Randal; Sureban, Sripathi; Weygant, Nathaniel; Qu, Dongfeng; Rao, Chinthalapally V; Dhanasekaran, Danny N; Bronze, Michael S; Houchen, Courtney W; Ali, Naushad

    2016-08-15

    Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. Chronic hepatitis C virus (HCV) infection causes induction of several tumors/cancer stem cell (CSC) markers and is known to be a major risk factor for development of HCC. Therefore, drugs that simultaneously target viral replication and CSC properties are needed for a risk-free treatment of advanced stage liver diseases, including HCC. Here, we demonstrated that (Z)-3,5,4'-trimethoxystilbene (Z-TMS) exhibits potent antitumor and anti-HCV activities without exhibiting cytotoxicity to human hepatocytes in vitro or in mice livers. Diethylnitrosamine (DEN)/carbon tetrachloride (CCl4) extensively induced expression of DCLK1 (a CSC marker) in the livers of C57BL/6 mice following hepatic injury. Z-TMS exhibited hepatoprotective effects against DEN/CCl4-induced injury by reducing DCLK1 expression and improving histologic outcomes. The drug caused bundling of DCLK1 with microtubules and blocked cell-cycle progression at G2-M phase in hepatoma cells via downregulation of CDK1, induction of p21(cip1/waf1) expression, and inhibition of Akt (Ser(473)) phosphorylation. Z-TMS also inhibited proliferation of erlotinib-resistant lung adenocarcinoma cells (H1975) bearing the T790M EGFR mutation, most likely by promoting autophagy and nuclear fragmentation. In conclusion, Z-TMS appears to be a unique therapeutic agent targeting HCV and concurrently eliminating cells with neoplastic potential during chronic liver diseases, including HCC. It may also be a valuable drug for targeting drug-resistant carcinomas and cancers of the lungs, pancreas, colon, and intestine, in which DCLK1 is involved in tumorigenesis. Cancer Res; 76(16); 4887-96. ©2016 AACR. PMID:27287718

  15. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside suppresses human colorectal cancer cell metastasis through inhibiting NF-κB activation.

    PubMed

    Lin, Chien-Liang; Hsieh, Shu-Ling; Leung, Wan; Jeng, Jiiang-Huei; Huang, Guan-Cheng; Lee, Chining-Ting; Wu, Chih-Chung

    2016-08-01

    2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG), a major component of Polygonum multiflorum Thunb (He-Shou-Wu), has been reported to exhibit antioxidant and anti-inflammatory effects. However, its anti-metastatic effect against colorectal cancer is still unclear. In this study, cell migration, invasion and adhesion abilities as well as metastasis-associated protein and NF-κB pathway signaling factor expression were analyzed after treating HT-29 cells with THSG. According to the results, the migration and invasiveness of HT-29 cells were reduced after treatment with 5 or 10 mM THSG (p<0.05). Additionally, the levels of matrix metalloproteinase-2 (MMP-2) and phosphorylated VE-cadherin in HT-29 cells were reduced and the transepithelial electrical resistance (TEER) of EA.hy926 endothelial cell monolayers was increased after incubation in THSG for 24 h (p<0.05). Cell adhesion ability and the E-selectin and intercellular adhesion molecule-1 (ICAM-1) protein levels were reduced when EA.hy926 endothelial cells were treated with THSG (p<0.05). In addition, the cytoplasmic phosphorylation of IκB, the nuclear p65 level and the DNA-binding activity of NF-κB were reduced after treating HT-29 or EA.hy926 cells with 5 or 10 mM THSG (p<0.05). These results suggest that THSG inhibits HT-29 cell metastasis by suppressing cell migration, invasion and adhesion. Furthermore, THSG inhibits metastasis-associated protein expression by suppressing NF-κB pathway activation. PMID:27278328

  16. Dynamic triggering of creep events in the Salton Trough, Southern California by regional M ≥ 5.4 earthquakes constrained by geodetic observations and numerical simulations

    NASA Astrophysics Data System (ADS)

    Wei, Meng; Liu, Yajing; Kaneko, Yoshihiro; McGuire, Jeffrey J.; Bilham, Roger

    2015-10-01

    Since a regional earthquake in 1951, shallow creep events on strike-slip faults within the Salton Trough, Southern California have been triggered at least 10 times by M ≥ 5.4 earthquakes within 200 km. The high earthquake and creep activity and the long history of digital recording within the Salton Trough region provide a unique opportunity to study the mechanism of creep event triggering by nearby earthquakes. Here, we document the history of fault creep events on the Superstition Hills Fault based on data from creepmeters, InSAR, and field surveys since 1988. We focus on a subset of these creep events that were triggered by significant nearby earthquakes. We model these events by adding realistic static and dynamic perturbations to a theoretical fault model based on rate- and state-dependent friction. We find that the static stress changes from the causal earthquakes are less than 0.1 MPa and too small to instantaneously trigger creep events. In contrast, we can reproduce the characteristics of triggered slip with dynamic perturbations alone. The instantaneous triggering of creep events depends on the peak and the time-integrated amplitudes of the dynamic Coulomb stress change. Based on observations and simulations, the stress change amplitude required to trigger a creep event of a 0.01-mm surface slip is about 0.6 MPa. This threshold is at least an order of magnitude larger than the reported triggering threshold of non-volcanic tremors (2-60 kPa) and earthquakes in geothermal fields (5 kPa) and near shale gas production sites (0.2-0.4 kPa), which may result from differences in effective normal stress, fault friction, the density of nucleation sites in these systems, or triggering mechanisms. We conclude that shallow frictional heterogeneity can explain both the spontaneous and dynamically triggered creep events on the Superstition Hills Fault.

  17. Determination of Z-3,5,4'-trimethoxystilbene in rat plasma by a simple HPLC method: application in a pre-clinical pharmacokinetic study.

    PubMed

    Lin, Hai-Shu; Zhang, Wei; Go, Mei Lin; Choo, Qiu-Yi; Ho, Paul C

    2010-11-01

    A simple HPLC method had been developed and validated to quantify Z-3,5,4'-trimethoxystilbene (Z-TMS), a phyto-stilbene with potent anti-cancer activities in rat plasma. Chromatographic separation was achieved on a reversed phase-HPLC column, which was protected by a guard column through a 13.5-min gradient delivery of a mixture of acetonitrile and water at a flow rate of 1.5 ml/min at 50 degrees C. The UV absorbance at 300 nm was recorded. Z-TMS and E-stilbene (internal standard) eluted at 8.8 and 9.3 min, respectively. The calibration curve was linear within the range of 33-2500 ng/ml (R(2)>0.9995) and 10 ng/ml was the lower limit of detection. The intra- and inter-day precisions were good and the relative standard deviation was all lower than 10%. The analytical recovery of Z-TMS in plasma ranged from 94.6+/-9.1% to 97.0+/-2.1%. This HPLC method was successfully applied to assess the pharmacokinetic profile of Z-TMS in Sprague-Dawley rats using hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) as a dosing vehicle. Although Z-TMS displayed negligible oral bioavailability, it had a fairly long terminal elimination half-life, abundant plasma drug exposure and limited clearance following intravenous administration. As Z-TMS had favorable intravenous pharmacokinetic profile, further investigation on its potential as a cancer chemotherapeutic agent is warranted. PMID:20427141

  18. 5-(4-hydroxy-3-dimethoxybenzylidene)-rhodanine (RD-1)-improved mitochondrial function prevents anxiety- and depressive-like states induced by chronic corticosterone injections in mice.

    PubMed

    Yang, Nan; Ren, Zhili; Zheng, Ji; Feng, Lu; Li, Dongmei; Gao, Kai; Zhang, Lianfeng; Liu, Yanyong; Zuo, Pingping

    2016-06-01

    Most current pharmacologic antidepressant treatments target monoaminergic systems confronts some problems such as low rate of remission and high risk for relapse indicating new therapeutic strategy is urgently need. Evidences showed that impairments in mitochondrial function were associated with the pathogenesis of mood disorders and improvement in its function may be a novel therapeutic choice. In the present study, effects of 5-(4-hydroxy-3-dimethoxybenzylidene)-2-thioxo-4-thiazolidinone (RD-1) were investigated in mice model of depression/anxiety induced by corticosterone (20 mg/kg) subcutaneously repeated injections in 5-week male BALB/c mice. Our results showed that five weeks of corticosterone administration induced anxiety/depressive-like behavioral changes, including decreased central activities in open field test, increased the immobility time in forced swimming test and the latency in the novelty-suppressed feeding test, as well as reduced bodyweight. Results showed that oral administration with RD-1 at the doses of 25, 50, and 100 mg/kg for five weeks significantly improved the anxiety/depressive-like behavioral changes induced by corticosterone. In glucose metabolism analysis by photon emission computed tomography/-computed tomography (PET/CT) imaging, corticosterone significantly deactivated the prefrontal cortex (PFC), temporal lobe and hippocampus. RD-1 treatment obviously improved the energy metabolism in the involved brain regions. In primary cultured hippocampal neuron, corticosterone reduced speed of anterograde transport, yet speed of retrograde transport was increased. Furthermore, RD-1 enhanced the mitochondrial anterograde transport to supply energy for the neurotransmitter release. In conclusion, RD-1 prevents anxiety/depressive-like behavior of mice induced by corticosterone repeated injections with novel mechanism of improvement in the mitochondrial function. PMID:26926430

  19. Search for Randall-Sundrum Gravitons in Dielectron and Diphoton Final States with 5.4fb-1 of D0 Data

    SciTech Connect

    Zhou, Ning; /Columbia U.

    2010-03-01

    A search for the lightest Kaluza-Klein mode of the graviton in the Randall-Sundrum model with a warped extra dimension is performed in the dielectron and diphoton channels. The data set used for the search corresponds to 5.4 fb{sup -1} of data from p{bar p} collisions at a center-of-mass energy of 1.96 TeV, collected with the D0 detector at the Fermilab Tevatron between July 2002 and Summer 2009. We search for resonances in the invariant mass spectrum of two electromagnetic showers from the decay of the graviton to either electron-positron pairs or photon pairs. To optimize the sensitivity, the dielectron and diphoton channels are analyzed separately, then the results are combined together in the end. We also investigate whether, due to the unique spin-2 nature of the graviton, the angular distribution of the final state particles can be used to significantly enhance the sensitivity of the search. We set 95% confidence level upper limits on the graviton production cross section times branching fraction into electron-positron pairs of between {approx} 7 fb and {approx} 0.5 fb for a range of graviton masses from 220 GeV and 1050 GeV, respectively. Compared with Randall-Sundrum model predictions, these results correspond to lower limits on the lightest graviton mass between 440 GeV and 1040 GeV, for the dimensionless graviton coupling to the Standard Model fields k/{bar M}{sub Pl} in the range from 0.01 to 0.1. In addition, for coupling k/{bar M}{sub Pl} of 0.01, gravitons with masses between 460 GeV and 560 GeV are also excluded at 95% confidence level. These results represent the most sensitive limits to date.

  20. Thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid, C 6H 2N 2O 4S 2, and its coordination polymers

    NASA Astrophysics Data System (ADS)

    Aprea, Alessia; Colombo, Valentina; Galli, Simona; Masciocchi, Norberto; Maspero, Angelo; Palmisano, Giovanni

    2010-05-01

    Thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid, C 6H 2N 2O 4S 2, was isolated as a polycrystalline material, and its crystal structure was determined by ab-initio X-ray powder diffraction (XRPD) methods. This species, upon deprotonation, was subsequently used in preparing the new coordination polymers Ag 2(C 6N 2O 4S 2), Mn(C 6N 2O 4S 2)(H 2O) 2, Co(C 6N 2O 4S 2)(H 2O) 2, Cu(C 6N 2O 4S 2)(H 2O) and Zn(C 6N 2O 4S 2)(H 2O) 2, fully characterized by analytical, thermal and XRPD structural methods - including in situ thermodiffractometry and simultaneous TGA and DSC. In the first-row transition metal derivatives, the [C 6N 2O 4S 2] 2- anion systematically prefers the N, O-chelating, vs. the expected O, O'-bridging, coordination mode, not allowing the formation of porous 3D frameworks. Indeed, these species are dense 1D coordination polymers. At variance, the silver derivative possesses a complex, dense 3D framework, due to the presence of μ 6-[C 6N 2O 4S 2] 2- ligands showing two μ 2-bridging carboxylates and two monohapto N-donor sites. When dehydration is viable, materials of E n(C 6N 2O 4S 2) formulation are irreversibly recovered ( n = 1 for E = Mn, Co, Zn, Cu; n = 2, for E = H).

  1. The regulatory effect of SC-236 (4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-l] benzenesulfonamide) on stem cell factor induced migration of mast cells

    SciTech Connect

    Kim, Su-Jin; Jeong, Hyun-Ja; Park, Rae-Kil; Lee, Kang-Min; Kim, Hyung-Min; Um, Jae-Young; Hong, Seung-Heon . E-mail: jooklim@wonkwang.ac.kr

    2007-04-15

    SC-236 (4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1-pyrazol-1-]benzenesulfonamide; C{sub 16}H{sub 11}ClF{sub 3}N{sub 3}O{sub 2}S), is a highly selective cyclooxygenase (COX)-2 inhibitor. Recently, there have been reports that SC-236 protects against cartilage damage in addition to reducing inflammation and pain in osteoarthritis. However, the mechanism involved in the inflammatory allergic reaction has not been examined. Mast cells accumulation can be related to inflammatory conditions, including allergic rhinitis, asthma, and rheumatoid arthritis. The aim of the present study is to investigate the effects of SC-236 on stem cell factor (SCF)-induced migration, morphological alteration, and cytokine production of rat peritoneal mast cells (RPMCs). We observed that SCF significantly induced the migration and morphological alteration. The ability of SCF to enhance migration and morphological alteration was abolished by treatment with SC-236. In addition, production of tumor necrosis factor (TNF)-{alpha}, interleukin (IL)-1{beta}, and vascular endothelial growth factor (VEGF) production induced by SCF was significantly inhibited by treatment with SC-236. Previous work has demonstrated that SCF-induced migration and cytokine production of mast cells require p38 MAPK activation. We also showed that SC-236 suppresses the SCF-induced p38 MAPK activation in RPMCs. These data suggest that SC-236 inhibits migration and cytokine production through suppression of p38 MAPK activation. These results provided new insight into the pharmacological actions of SC-236 and its potential therapeutic role in the treatment of inflammatory allergic diseases.

  2. Quantum chemical computational studies on 5-(4-bromophenylamino)-2-methylsulfanylmethyl-2H-1,2,3-triazol-4-carboxylic acid ethyl ester

    NASA Astrophysics Data System (ADS)

    Tokatlı, Ahmet; Özen, Emrah; Ucun, Fatih; Bahçeli, Semiha

    2011-03-01

    The optimized molecular geometry, vibrational frequencies, and gauge including atomic orbital (GIAO) 1H and 13C NMR shift values of 5-(4-bromophenylamino)-2-methylsulfanylmethyl-2H-1,2,3-triazol-4-carboxylic acid ethyl ester have been calculated by using Hartree-Fock (HF) and density functional method (DFT/B3LYP) with 6-31G(d), 6-31G(d,p) and LANL2DZ basis sets. The optimized molecular geometric parameters were presented and compared with the data obtained from X-ray diffraction. In order to fit the calculated harmonic wavenumbers to the experimentally observed ones, scaled quantum mechanics force field (SQM FF) methodology was proceeded. Correlation factors between the experimental and calculated 1H chemical shift values of the title compound in vacuum and in CHCl 3 solution by using the conductor-like screening continuum solvation model (COSMO) were reported. The calculated results showed that the optimized geometry well reproduces the crystal structure. The theoretical vibrational frequencies and chemical shifts are in very good agreement with the experimental data. In solvent media the energetic behavior of the title compound was also examined by using the B3LYP method with the 6-31G(d) basis set, applying the COSMO model. The obtained results indicated that the total energy of the title compound decreases with increasing polarity of the solvent. Furthermore, molecular electrostatic potential (MEP), natural bond orbital (NBO) and frontier molecular orbitals (FMOs) of the title compound were performed by the B3LYP/LANL2DZ method, and also thermodynamic parameters for the title compound were calculated at all the HF and B3LYP levels.

  3. Structural variations and photoluminescent properties of a series of metal-organic frameworks constructed from 5-(4-carboxybenzoylamino)-isophthalic acid

    SciTech Connect

    Zhao, Wen; Zhang, Li-Juan; Zhao, Xiao-Li

    2013-06-01

    Five new metal-organic frameworks (MOFs) with 5-(4-carboxybenzoylamino)-isophthalic acid (H₃L), namely, [Cd₉L₆(DMA)₆]·4DMA (1), [Cd₃L₂(H₂O)₉]·4H₂O (2), [LaL(H₂O)₄]·2H₂O (3), [CeL(H₂O)₄]·H₂O (4) and [Tb(HL)(H₂L)(H₂O)₃]·5H₂O (5) (DMA=N,N-dimethylacetamide), have been synthesized. Complex 1 shows a three-dimensional architecture generated from linkage of Cd–O chains via L³⁻ ligands. Minor variations in synthetic conditions of 1 afforded 2, which features an interesting 2D→3D catenation architecture containing helical chains. Complexes 3 and 4 are isostructural and each feature a two-dimensional architecture constructed from the linkage of L³⁻ with Ln³⁺. Complex 5 displays a chain-like structure, of which the most interesting feature is the existence of free carboxylic acid (–COOH) group which may confer unique functionality. Moreover, the investigations of the thermal stability, powder X-ray diffractions and solid-state photoluminescent properties for these crystalline materials have been carried out. - Graphical Abstract: Solvothermal reactions of tricarboxylate ligand H₃L with Cd²⁺/Ln³⁺ has yielded a series of new MOFs containing interesting structural motifs. Highlights: • A tricarboxylate ligand whose coordinating functionalities are not symmetry equivalent is employed to construct MOFs. • Complex 2 features an interesting 2D→3D catenation architecture containing helical chains. • Complex 3 feature chain-like structure containing free – COOH group, which may confer unique functionality. • Photoluminescent properties and thermal behaviors for 1–5 have been reported.

  4. Discovery of a Millisecond Pulsar in the 5.4 day Binary 3FGL J1417.5-4402: Observing the Late Phase of Pulsar Recycling

    NASA Astrophysics Data System (ADS)

    Camilo, F.; Reynolds, J. E.; Ransom, S. M.; Halpern, J. P.; Bogdanov, S.; Kerr, M.; Ray, P. S.; Cordes, J. M.; Sarkissian, J.; Barr, E. D.; Ferrara, E. C.

    2016-03-01

    In a search of the unidentified Fermi gamma-ray source 3FGL J1417.5-4402 with the Parkes radio telescope, we discovered PSR J1417-4402, a 2.66 ms pulsar having the same 5.4 day orbital period as the optical and X-ray binary identified by Strader et al. The existence of radio pulsations implies that the neutron star is currently not accreting. Substantial outflows from the companion render the radio pulsar undetectable for more than half of the orbit, and may contribute to the observed Hα emission. Our initial pulsar observations, together with the optically inferred orbit and inclination, imply a mass ratio of 0.171 ± 0.002, a companion mass of {M}2=0.33+/- 0.03 M⊙, and a neutron star mass in the range 1.77≤slant {M}1≤slant 2.13 M⊙. However, there remains a discrepancy between the distance of 4.4 kpc inferred from the optical properties of the companion and the smaller radio dispersion measure distance of 1.6 kpc. The smaller distance would reduce the inferred Roche-lobe filling factor, increase the inferred inclination angle, and decrease the masses. As a wide binary, PSR J1417-4402 differs from the radio-eclipsing black widow and redback pulsars being discovered in large numbers by Fermi. It is probably a system that began mass transfer onto the neutron star after the companion star left the main sequence. The companion should end its evolution as a He white dwarf in a 6-20 day orbit, i.e., as a typical binary millisecond pulsar companion.

  5. Crystal structure of 4-({(1E,2E)-3-[3-(4-fluoro­phen­yl)-1-isopropyl-1H-indol-2-yl]allyl­idene}amino)-5-methyl-1H-1,2,4-triazole-5(4H)-thione

    PubMed Central

    Kulkarni, Ajaykumar D.; Rahman, Md. Lutfor; Mohd. Yusoff, Mashitah; Kwong, Huey Chong; Quah, Ching Kheng

    2015-01-01

    The title compound, C23H22FN5S, exists in a trans conformation with respect to the methene C=C and the acyclic N=C bonds. The 1,2,4-triazole-5(4H)-thione ring makes dihedral angles of 88.66 (9) and 84.51 (10)°, respectively, with the indole and benzene rings. In the crystal, mol­ecules are linked by pairs of N—H⋯S hydrogen bonds, forming inversion dimers with an R 2 2(8) ring motif. The dimers are linked via C—H⋯π inter­actions, forming chains along [1-10]. The chains are linked via π—π inter­actions involving inversion-related triazole rings [centroid–centroid distance = 3.4340 (13) Å], forming layers parallel to the ab plane. PMID:26594522

  6. Crystal structure of (5-chloro-2-hy-droxy-phen-yl)(3-methyl-isoxazolo[5,4-b]pyridin-5-yl)methanone.

    PubMed

    Raja, Rajamani; Poomathi, Nataraj; Perumal, Paramasivam T; SubbiahPandi, A

    2015-11-01

    In the title compound, C14H9ClN2O3, the fused pyridine and isoxazole rings are approximately planar, making a dihedral angle of 1.14 (16)°. The mol-ecule is twisted with the benzene ring and the mean plane through the fused pyridine-isoxazole ring system being inclined to one another by 47.03 (13)°. There is an intra-molecular O-H⋯O hydrogen bond forming an S(6) ring motif. In the crystal, mol-ecules are linked by C-H⋯N hydrogen bonds, forming chains propagating along [001]. The chains are linked by slipped parallel π-π inter-actions, involving inversion-related benzene rings, forming slabs lying parallel to the bc plane {inter-centroid distance = 3.770 (2) Å]. PMID:26594574

  7. Crystal structure of 2-(adamantan-1-yl)-5-(4-bromo-phen-yl)-1,3,4-oxa-diazole.

    PubMed

    Alzoman, Nourah Z; El-Emam, Ali A; Ghabbour, Hazem A; Chidan Kumar, C S; Fun, Hoong-Kun

    2014-12-01

    In the title mol-ecule, C18H19BrN2O, the benzene ring is inclined to the oxa-diazole ring by 10.44 (8)°. In the crystal, C-H⋯π inter-actions link the mol-ecules in a head-to-tail fashion, forming chains extending along the c-axis direction. The chains are further connected by π-π stacking inter-actions, with centroid-centroid distances of 3.6385 (7) Å, forming layers parallel to the bc plane. PMID:25553016

  8. 7-Difluoromethoxyl-5,4'-di-n-octyl genistein inhibits the stem-like characteristics of gastric cancer stem-like cells and reverses the phenotype of epithelial-mesenchymal transition in gastric cancer cells.

    PubMed

    Cao, Xiaozheng; Ren, Kaiqun; Song, Zhengwei; Li, Duo; Quan, Meifang; Zheng, Yu; Cao, Jianguo; Zeng, Wenbin; Zou, Hui

    2016-08-01

    7-Difluoromethoxyl-5,4'-di-n-octyl genistein (DFOG), a novel synthetic genistein analogue, exerts anticarcinogenic activity in several types of cancers, including gastric cancer. Accumulating evidence in recent years strongly indicates the existence of cancer stem cells in gastric cancer. The objective of the present study was to investigate whether DFOG inhibits the stemness and reverses the epithelial-mesenchymal transition (EMT) phenotype of gastric cancer stem-like cells (GCSLCs) derived from human gastric cancer SGC-7901 cells and to identify its potential mechanism. Sphere-forming cells (SFCs) from the SGC-7901 cells possessed the properties of GCSLCs. DFOG preferentially inhibited self-renewal, cell migration and cell invasion, and downregulated the expression of stem cell biomarkers in a dose-dependent manner. At the molecular level, these effects were accompanied by the downregulation of forkhead box M1 (FoxM1). Meanwhile, FoxM1 siRNA transfection was able to synergize the inhibition of expression of FoxM1 and Twist1 induced by DFOG in GCSLCs. In addition, we found that DFOG treatment decreased the expression of N-cadherin and increased the expression of E-cadherin. More importantly, FoxM1 siRNA transfection cooperated with DFOG to suppress the self-renewal capacity, cell migration and cell invasion, and downregulated the expression of CD133, CD44, ALDH1, and also regulated the expression of N-cadherin and E-cadherin. These findings showed that DFOG inhibited the stem-like characteristics of GCSLCs and reversed the EMT phenotype by modulation of FoxM1 and further decreased Twist1 expression. Our results provide a further rationale and experimental basis for using DFOG to improve the efficacy of treatment for patients with gastric cancer. PMID:27279287

  9. The october 31 (Ml 5.4) and november 1 (Ml 5.3) Molise earthquakes (southern italy):first results from geochemistry

    NASA Astrophysics Data System (ADS)

    Pizzino, L.; Cinti, D.; Barbieri, M.; Galli, G.; Voltattorni, N.; Quattrocchi, F.

    2003-04-01

    Two geochemical surveys have been performed in November and December 2002 in the Molise region (southern Italy) and surrounding areas struck by two moderate size earthquakes on October 31 (M_l 5.4) and on November 1 (M_l 5.3). The main goals of this study were: i) to highlight eventual variations either in the physico-chemical features or in the chemistry of thermo-mineral and cold springs (already sampled in 1997) discharging in an area located 50 km far from the epicentral one (Sannio-Matese, Campania region),; ii) to determine the chemical features of the groundwater discharging in the epicentral area, identifying the location and the extension of the various existing aquifers; iii) to collect information about eventual changes occurred in springs and wells (variations in flows, groundwater level in wells, etc.). Moreover, twice a week samplings have been carried out for two months at two important sulphurous springs (Larino spring, in the epicentral area and Telese thermo-mineral spring, in the Sannio area) in order to gather temporal chemical trend during the ongoing seismicity. We sampled a total of 35 sites (8 springs and wells in the Sannio-Matese area and 27 in the epicentral one) measuring in the field: temperature, pH, Eh, electrical conductivity, as well as radon, bicarbonate and H_2S contents. In laboratory, analyses of major, minor and trace elements have been performed, together with dissolved gas compositions. On 10 selected samples δ13C and 87/86Sr analyses are in progress. Data collected in the second survey show, for springs and wells located in the epicentral area, an evident pH and Eh increase (probably they returned to normal pre-earthquake values) together with some chemical variations; on the contrary, springs located in the Sannio-Matese area showed no variations. Local people observed sin-earthquake flow increases and variations in turbidity in two springs discharging in the epicentral area. All detected groundwater changes are discussed

  10. The october 31 (Ml 5.4) and november 1 (Ml 5.0) 2002 Molise earthquakes: first results from fluid geochemistry

    NASA Astrophysics Data System (ADS)

    Pizzino, L.; Cinti, D.; Barbieri, M.; Galli, G.; Voltattorni, N.; Quattrocchi, F.

    2003-04-01

    Two geochemical surveys have been performed in November and December 2002 in the Molise region (southern Italy) and surrounding areas struck by two moderate size earthquakes on October 31 (M_l 5.4) and on November 1 (M_l 5.3). The main goals of this study were: i) to highlight eventual variations either in the physico-chemical features or in the chemistry of thermo-mineral and cold springs (already sampled in 1997) discharging in an area located 50 km far from the epicentral one (Sannio-Matese, Campania region),; ii) to determine the chemical features of the groundwater discharging in the epicentral area, identifying the location and the extension of the various existing aquifers; iii) to collect information about eventual changes occurred in springs and wells (variations in flows, groundwater level in wells, etc.). Moreover, twice a week samplings have been carried out for two months at two important sulphurous springs (Larino spring, in the epicentral area and Telese thermo-mineral spring, in the Sannio area) in order to gather temporal chemical trend during the ongoing seismicity. We sampled a total of 35 sites (8 springs and wells in the Sannio-Matese area and 27 in the epicentral one) measuring in the field: temperature, pH, Eh, electrical conductivity, as well as radon, bicarbonate and H_2S contents. In laboratory, analyses of major, minor and trace elements have been performed, together with dissolved gas compositions. On 10 selected samples δ13C and 87/86Sr analyses are in progress. Data collected in the second survey show, for springs and wells located in the epicentral area, an evident pH and Eh increase (probably they returned to normal pre-earthquake values) together with some chemical variations; on the contrary, springs located in the Sannio-Matese area showed no variations. Local people observed sin-earthquake flow increases and variations in turbidity in two springs discharging in the epicentral area. All detected groundwater changes are discussed

  11. 2-Methyl­sulfanyl-1,2,4-triazolo[1,5-a]quinazolin-5(4H)-one

    PubMed Central

    Al-Salahi, Rashad; Al-Omar, Mohamed; Abbas, Mohammed; Ng, Seik Weng

    2012-01-01

    The non-H atoms of the title compound, C10H8N4OS, lie approximately in a common plane (r.m.s. deviation = 0.058 Å). In the crystal, two mol­ecules are linked across a center of inversion by a pair of N—H⋯N hydrogen bonds, forming a a dimer. PMID:22719577

  12. Accounting Forms. Instructor's Handbook.

    ERIC Educational Resources Information Center

    Itter, Pat

    Supporting performance objective of the 16 V-TECS (Vocational-Technical Education Consortium of States) Bookkeeper Catalog, this instructor's manual contains copies of accounting forms which can be used to make spirit masters or transparencies. (This module is the first in a set of ten on bookkeeping [CE 019 480-489].) Twenty forms grouped under…

  13. Method of forming nanodielectrics

    DOEpatents

    Tuncer, Enis [Knoxville, TN; Polyzos, Georgios [Oak Ridge, TN

    2014-01-07

    A method of making a nanoparticle filled dielectric material. The method includes mixing nanoparticle precursors with a polymer material and reacting the nanoparticle mixed with the polymer material to form nanoparticles dispersed within the polymer material to form a dielectric composite.

  14. Method for forming materials

    DOEpatents

    Tolle, Charles R.; Clark, Denis E.; Smartt, Herschel B.; Miller, Karen S.

    2009-10-06

    A material-forming tool and a method for forming a material are described including a shank portion; a shoulder portion that releasably engages the shank portion; a pin that releasably engages the shoulder portion, wherein the pin defines a passageway; and a source of a material coupled in material flowing relation relative to the pin and wherein the material-forming tool is utilized in methodology that includes providing a first material; providing a second material, and placing the second material into contact with the first material; and locally plastically deforming the first material with the material-forming tool so as mix the first material and second material together to form a resulting material having characteristics different from the respective first and second materials.

  15. In Situ Determination of Tacticity, Deactivation, and Kinetics in [rac-(C2H4(1-Indenyl)2)ZrMe][B(C6F5)4] and [Cp2ZrMe][B(C6F5)4]-Catalyzed Polymerization of 1-Hexene Using (13)C Hyperpolarized NMR.

    PubMed

    Chen, Chia-Hsiu; Shih, Wei-Chun; Hilty, Christian

    2015-06-01

    The stereochemistry, kinetics, and mechanism of olefin polymerization catalyzed by a set of zirconium-based metallocenes was studied by NMR using dissolution dynamic nuclear polarization (DNP). Hyperpolarized 1-hexene was polymerized in situ with a C2 symmetric catalyst, [(EBI)ZrMe][B(C6F5)4] (EBI = rac-(C2H4(1-indenyl)2)), and a C2v symmetric catalyst, [(Cp)2ZrMe][B(C6F5)4] (Cp = cyclopentadienyl). Hyperpolarized (13)C NMR spectra were used to characterize product tacticity following initiation of the reaction. At the same time, a signal gain of 3 orders of magnitude from (13)C hyperpolarization enabled the real time observation of catalyst-polymeryl species and deactivation products, such as vinylidene and a Zr-allyl complex. The compounds appearing in the reaction provide evidence for the existence of β-hydride elimination and formation of a dormant site via a methane-generating mechanism. The presence of a deactivating mechanism was incorporated in a model used to determine kinetic parameters of the reaction. On this basis, rate constants were measured between 0.8 and 6.7 mol % of catalyst. The concentration dependence of the rate constants obtained indicates a second-order process for polymerization concomitant with a first-order process for deactivation. The simultaneous observation of both processes in the time evolution of (13)C NMR signals over the course of several seconds underlines the utility of hyperpolarized NMR for quantifying early events in polymerization reactions. PMID:25961793

  16. Spin forming development

    SciTech Connect

    Gates, W.G.

    1982-05-01

    Bendix product applications require the capability of fabricating heavy gage, high strength materials. Five commercial sources have been identified that have the capability of spin forming metal thicknesses greater than 9.5 mm and four equiment manufacturers produce machines with this capability. Twelve assemblies selected as candidates for spin forming applications require spin forming of titanium, 250 maraging steel, 17-4 pH stainless steel, Nitronic 40 steel, 304 L stainless steel, and 6061 aluminum. Twelve parts have been cold spin formed from a 250 maraging steel 8.1 mm wall thickness machine preform, and six have been hot spin formed directly from 31.8-mm-thick flat plate. Thirty-three Ti-6Al-4V titanium alloy parts and 26 17-4 pH stainless steel parts have been hot spin formed directly from 31.8-mm-thick plate. Hot spin forming directly from plate has demonstrated the feasibility and favorable economics of this fabrication technique for Bendix applications.

  17. 3-Benzamidomethyl-4-[(E)-2-chloro­benzyl­ideneamino]-1H-1,2,4-triazole-5(4H)-thione

    PubMed Central

    Fun, Hoong-Kun; Jebas, Samuel Robinson; Rao, Jyothi N.; Kalluraya, B.

    2009-01-01

    In the title compound, C17H14ClN5OS, the dihedral angles formed by the two benzene rings with the triazole ring are 66.88 (3) and 19.16 (3)°, and the benzene rings are inclined to each other with a dihedral angle of 78.40 (3)°. Inter­molecular N—H⋯O hydrogen bonds link the mol­ecules into layers parallel to the (100) planes, and centrosymmetric π–π stacking inter­actions [centroid–centroid distance = 3.7717 (5) Å] are formed between benzene rings in neighbouring layers. PMID:21581689

  18. Crystal structure of poly[[{μ2-1,4-bis[(1H-imid­azol-1-yl)methyl]benzene}[μ6-5-(4-carboxylatophenoxy)isophthalato]-μ3-hydroxido-dicobalt(II)] 0.25-hydrate

    PubMed Central

    Li, Yaping; Sun, Dajun; Ming, Julia; Han, Liying; Su, Guanfang

    2014-01-01

    The title coordination polymer, {[Co2(C15H7O7)(OH)(C14H14N4)]·0.25H2O}n, was synthesized under hydro­thermal conditions. The asymmetric unit contains two Co2+ ions, one L 3− anion originating from 5-(4-carb­oxy­phen­oxy)isophthalic acid (H3 L), one OH− ligand, one 1,4-bis­[(1H-imidazol-l-yl)meth­yl]benzene (bix) ligand and one disordered lattice water mol­ecule (occupancy 0.25). The two Co2+ ions have different environments. One has an octa­hedral O4N2 coordin­ation sphere, defined by four O atoms from three carboxyl­ate groups and one OH− ligand, and two N atoms from two symmetry-related bix ligands. The other has a trigonal-bipyramidal O5 coordination sphere resulting from three carboxyl­ate groups and two OH− ligands. The dihedral angles between the two benzene rings in the L 3− ligand and between the benzene ring and the two imidazole rings in the bix ligand are 67.05 (15), 75.27 (17) and 82.05 (17)°, respectively. Four neighbouring Co2+ ions are linked by six carboxyl­ate groups and two μ 3-OH ligands, forming a butterfly-shaped secondary building unit (SBU). These SBUs are connected by L 3− anions into layers parallel to (1-10). Adjacent layers are cross-linked by the bix ligands, forming a three-dimensional framework that has a bimodal (3,8)-connected tfz-d topology. The disordered lattice water mol­ecule is located in the voids of the framework and has O⋯O and O⋯N contacts of 2.81 (2) and 2.95 (2) Å, suggesting medium-strength hydrogen bonds. The title compound may be a good candidate for artificial eye lenses. PMID:25484783

  19. Investigation of ULF magnetic pulsations, air conductivity changes, and infra red signatures associated with the 30 October Alum Rock M5.4 earthquake

    NASA Astrophysics Data System (ADS)

    Bleier, T.; Dunson, C.; Maniscalco, M.; Bryant, N.; Bambery, R.; Freund, F.

    2009-04-01

    Several electromagnetic signal types were observed prior to and immediately after 30 October 2007 (Local Time) M5.4 earthquake at Alum Rock, Ca with an epicenter ~15 km NE of San Jose Ca. The area where this event occurred had been monitored since November 2005 by a QuakeFinder magnetometer site, unit 609, 2 km from the epicenter. This instrument is one of 53 stations of the QuakeFinder (QF) California Magnetometer Network-CalMagNet. This station included an ultra low frequency (ULF) 3-axis induction magnetometer, a simple air conductivity sensor to measure relative airborne ion concentrations, and a geophone to identify the arrival of the P-wave from an earthquake. Similar in frequency content to the increased ULF activity reported two weeks prior to the Loma Prieta M7.0 quake in 1989 (Fraser-Smith, 1990, 1991), the QF station detected activity in the 0.01-12 Hz bands, but it consisted of an increasing number of short duration (1 to 30 s duration) pulsations. The pulsations peaked around 13 days prior to the event. The amplitudes of the pulses were strong, (3-20 nT), compared to the average ambient noise at the site, (10-250 pT), which included a component arising from the Bay Area Rapid Transit (BART) operations. The QF station also detected different pulse shapes, e.g. negative or positive only polarity, with some pulses including a combination of positive and negative. Typical pulse counts over the previous year ranged from 0-15 per day, while the count rose to 176 (east-west channel) on 17 October, 13 days prior to the quake. The air conductivity sensor saturated for over 14 h during the night and morning prior to the quake, which occurred at 20:29 LT. Anomalous IR signatures were also observed in the general area, within 50 km of the epicenter, during the 2 weeks prior to the quake. These three simultaneous EM phenomena were compared with data collected over a 1-2-year period at the site. The data was also compared against accounts of air ionization reported

  20. Electromagnetic nucleon form factors

    SciTech Connect

    Bender, A.; Roberts, C.D.; Frank, M.R.

    1995-08-01

    The Dyson-Schwinger equation framework is employed to obtain expressions for the electromagnetic nucleon form factor. In generalized impulse approximation the form factor depends on the dressed quark propagator, the dressed quark-photon vertex, which is crucial to ensuring current conservation, and the nucleon Faddeev amplitude. The approach manifestly incorporates the large space-like-q{sup 2} renormalization group properties of QCD and allows a realistic extrapolation to small space-like-q{sup 2}. This extrapolation allows one to relate experimental data to the form of the quark-quark interaction at small space-like-q{sup 2}, which is presently unknown. The approach provides a means of unifying, within a single framework, the treatment of the perturbative and nonperturbative regimes of QCD. The wealth of experimental nucleon form factor data, over a large range of q{sup 2}, ensures that this application will provide an excellent environment to test, improve and extend our approach.

  1. Image forming apparatus

    DOEpatents

    Satoh, Hisao; Haneda, Satoshi; Ikeda, Tadayoshi; Morita, Shizuo; Fukuchi, Masakazu

    1996-01-01

    In an image forming apparatus having a detachable process cartridge in which an image carrier on which an electrostatic latent image is formed, and a developing unit which develops the electrostatic latent image so that a toner image can be formed, both integrally formed into one unit. There is provided a developer container including a discharge section which can be inserted into a supply opening of the developing unit, and a container in which a predetermined amount of developer is contained, wherein the developer container is provided to the toner supply opening of the developing unit and the developer is supplied into the developing unit housing when a toner stirring screw of the developing unit is rotated.

  2. Handprinted Forms and Characters

    National Institute of Standards and Technology Data Gateway

    NIST Handprinted Forms and Characters (PC database for purchase)   NIST Special Database 19 contains NIST's entire corpus of training materials for handprinted document and character recognition. It supersedes NIST Special Databases 3 and 7.

  3. Shell forming system

    NASA Technical Reports Server (NTRS)

    Kendall, Jr., James M. (Inventor); Wang, Taylor G. (Inventor); Elleman, Daniel D. (Inventor)

    1990-01-01

    Hollow shells of high uniformity are formed by emitting liquid through an outer nozzle and gas through an inner nozzle, to form a hollow extrusion, by flowing the gas at a velocity between about 1.3 and 10 times the liquid velocity. The natural breakup rate of the extrusion can be increased to decrease shell size by applying periodic perturbations to one of the materials prior to exiting the nozzles, to a nozzle, or to the extrusion.

  4. Highly tunable fluorinated trispyrazolylborates [HB(3-CF3-5-{4-RPh}pz)3](-) (R = NO2, CF3, Cl, F, H, OMe and NMe2) and their copper(I) complexes.

    PubMed

    van Dijkman, Thomas F; Siegler, Maxime A; Bouwman, Elisabeth

    2015-12-28

    The ethene and carbon monoxide adducts of copper(I) with seven trispyrazolylborate ligands ([HB(3-CF3-5-{4-RPh}pz)3](-); R = NO2 (4a), CF3 (4b), Cl (4c), F (4d), H (4e), OMe (4f) and NMe2 (4g)) were synthesized and characterized. The ligands were synthesized from their corresponding pyrazoles and sodium tetrahydridoborate and were obtained as solvent adducts of their sodium salts after workup. When the pyrazole with the most electron-withdrawing substituent (R = NO2) is used the asymmetric ligand [HB(3-CF3-5-{4-NO2Ph}pz)2(3-{4-NO2Ph}-5-CF3pz)](-) (4a') is formed as the major product. Copper(I) complexes with ethene or CO as a co-ligand were prepared in good yields and were structurally characterized using (1)H NMR, (13)C NMR and infrared spectroscopy. Single crystal X-ray crystallography analyses revealed the structures of Na4a', Na4b, four copper ethene complexes and four copper carbonyl complexes. The structures of the copper(I) complexes show Cu(I) ions in pseudo-tetrahedral coordination environments consisting of three nitrogen atoms of the trispyrazolylborate ligand and the carbonyl or η(2)-coordinated ethene ligands, with nearly identical coordination environments around the Cu(I) ion. The compound [Na(4a')(H2O)]n crystallizes as one-dimensional chains with intermolecular NaO2N interactions. The sodium ions were found in severely distorted octahedral geometries with three nitrogen atoms from the trispyrazolylborate ligand, one aqua ligand and two oxygen atoms from the nitro group of an adjacent molecule. The compound [Na2(4b)2(μ-H2O)2] crystallizes as a centrosymmetric water-bridged dimer: two five-coordinate square-pyramidal sodium ions each are coordinated facially by three nitrogen atoms from a trispyrazolylborate ligand and two bridging water ligands. Below the base of the pyramidal structure one intermolecular and two intramolecular NaF short contacts are present. The (1)H and (13)C NMR spectra of the copper-ethene complexes show signals for the ethene

  5. Composite hot drape forming

    NASA Technical Reports Server (NTRS)

    Ott, Thomas

    1994-01-01

    This program was initiated to replace labor-intensive ply-by-ply layup of composite I-beam posts and angle stiffeners used in the Space Station Freedom (SSF) rack structure. Hot drape forming (HDF) has been successfully implemented by BCAG for 777 composite I-stringers and by Bell Helicopter/Textron for the V-22 I-stingers. The two companies utilize two vastly different approaches to the I-beam fabrication process. A drape down process is used by Bell Helicopter where the compacted ply charge is placed on top of a forming mandrel and heated. When the heated ply charge reached a set temperature, vacuum pressure is applied and the plies are formed over the mandrel. The BCAG 777 process utilizes an inverted forming process where the ply stack is placed on a forming table and the mandrel is inverted and placed upon the ply stack. A heating and vacuum bladder underneath the ply stack form the play stack up onto the mandrels after reaching the temperature setpoint. Both methods have their advantages, but the drape down process was selected for SSF because it was more versatile and could be fabricated from readily available components.

  6. Composite hot drape forming

    NASA Astrophysics Data System (ADS)

    Ott, Thomas

    1994-02-01

    This program was initiated to replace labor-intensive ply-by-ply layup of composite I-beam posts and angle stiffeners used in the Space Station Freedom (SSF) rack structure. Hot drape forming (HDF) has been successfully implemented by BCAG for 777 composite I-stringers and by Bell Helicopter/Textron for the V-22 I-stingers. The two companies utilize two vastly different approaches to the I-beam fabrication process. A drape down process is used by Bell Helicopter where the compacted ply charge is placed on top of a forming mandrel and heated. When the heated ply charge reached a set temperature, vacuum pressure is applied and the plies are formed over the mandrel. The BCAG 777 process utilizes an inverted forming process where the ply stack is placed on a forming table and the mandrel is inverted and placed upon the ply stack. A heating and vacuum bladder underneath the ply stack form the play stack up onto the mandrels after reaching the temperature setpoint. Both methods have their advantages, but the drape down process was selected for SSF because it was more versatile and could be fabricated from readily available components.

  7. Dehydration of raffinose pentahydrate: structures of raffinose 5-, 4.433-, 4.289- and 4.127-hydrate at 93 K.

    PubMed

    Viriyarattanasak, Chotika; Shiro, Motoo; Munekawa, Shigeru; Franks, Felix; Ikeda, Satomi; Kajiwara, Kazuhito

    2015-11-01

    Raffinose [or O-α-D-galactopyranosyl-(1→6)-α-D-glucopyranosyl-(1→2)-β-D-fructofuranoside] pentahydrate, C18H32O16·5H2O, (I), and three lower hydrates, namely the 4.433-, (II), 4.289-, (III), and 4.127-hydrated, (IV), forms, obtained in the course of the dehydration of (I), have been studied. The unit cells in the space group P2₁2₁2₁ are of similar dimensions for all the crystals. The conformation of the raffinose molecules remains almost the same across the four crystal structures. The raffinose molecules are linked into a three-dimensional hydrogen-bonded network involving all the -OH groups, the ring and glycosidic O atoms, and the water molecules. Six water sites were identified in the structures of (II), (III) and (IV), of which W1, W4 and W6 (W = water) are partially occupied with their populations coupled. W1, W4 and one of the -OH groups of the galactose ring form an infinite hydrogen-bonding chain around a 2₁ axis parallel to the a axis (denoted chain A), and W6 and the same -OH group form a similar chain (chain A') disordered with chain A. The occupancy ratio of chain A to chain A' for N-hydrates (N is a hydration number between 4 and 5) is (N - 4):(5 - N). The transformation of chain A to chain A' as part of the dehydration process has little effect on the rest of the structure. Thus, the dehydration proceeds without significant impact on the crystal structure. PMID:26524166

  8. Laser forming process development

    SciTech Connect

    Blake, R.J.

    1996-12-31

    This paper is a summary of the activities performed for the process development of laser thermal forming sheet metal parts in support of rapid prototyping. A 400 watt pulsed Nd:YAG laser and 50 watt desktop CO{sub 2} laser were used during initial process development. Several tool-assisted laser forming approaches were conceived during the development of the process, and simple fixtures for process development/understanding were used throughout all testing. Much of the actual forming was performed with the base material in an unfixtured state. CRES (304) was used for baseline development, but the effort was directed toward forming titanium (e.g., 6Al-4V, 15V-3Cr-3Sn-3Al). Several DOE (i.e., Design of Experiment) techniques were employed during development and a Neural Net Computer Model was conceived for process control. This program was a joint effort in cooperation with the American Welding Society under contract with the Defense Advanced Research Projects Agency (DARPA). A synopsis of the laser forming process development, future opportunities, and applications are presented.

  9. Methods for forming particles

    DOEpatents

    Fox, Robert V.; Zhang, Fengyan; Rodriguez, Rene G.; Pak, Joshua J.; Sun, Chivin

    2016-06-21

    Single source precursors or pre-copolymers of single source precursors are subjected to microwave radiation to form particles of a I-III-VI.sub.2 material. Such particles may be formed in a wurtzite phase and may be converted to a chalcopyrite phase by, for example, exposure to heat. The particles in the wurtzite phase may have a substantially hexagonal shape that enables stacking into ordered layers. The particles in the wurtzite phase may be mixed with particles in the chalcopyrite phase (i.e., chalcopyrite nanoparticles) that may fill voids within the ordered layers of the particles in the wurtzite phase thus produce films with good coverage. In some embodiments, the methods are used to form layers of semiconductor materials comprising a I-III-VI.sub.2 material. Devices such as, for example, thin-film solar cells may be fabricated using such methods.

  10. Crystal structure of (Z)-4-[1-(4-acetyl-anilino)ethyl-idene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one.

    PubMed

    Mahfouz, Refaat M; Demircioğlu, Zeynep; Abbady, Mohamed S; Büyükgüngör, Orhan

    2015-01-01

    In the solid state, the title compound, C20H19N3O2, adopts the keto-amine tautomeric form, with the H atom attached to the N atom, which participates in an intra-molecular N-H⋯O hydrogen bond with an S(6) ring motif. The dihedral angles between the pyrazole ring and the phenyl and benzene rings are 3.69 (10) and 46.47 (9)°, respectively. In the crystal, mol-ecules are linked by weak C-H⋯O hydrogen bonds, generating C(16) chains propagating in [301]. Weak aromatic π-π stacking inter-actions [centroid-centroid distances = 3.6123 (10) and 3.6665 (10) Å] link the chains into a three-dimensional network. PMID:25705461

  11. Changing Organizational Forms.

    ERIC Educational Resources Information Center

    1997

    This document contains three papers from a symposium on changing organizational forms. "Goal Integration in a Multi-divisional Organization" (Richard J. Torraco, Mary Finnegan), reports on a study that examined how goals are integrated into organizational activities once they have been identified, proposes a model of goal integration, and develops…

  12. Literature: External Forms.

    ERIC Educational Resources Information Center

    Regional Curriculum Project, Atlanta, GA.

    This curriculum guide, developed as part of a total English curriculum for pre-kindergarten through grade 10, suggests that students can best understand literature by understanding its recurring external forms or genres, and includes (1) an overview describing the four literary genres of drama, narrative poetry, narrative fiction, and lyric poetry…

  13. Literature: Internal Forms.

    ERIC Educational Resources Information Center

    Regional Curriculum Project, Atlanta, GA.

    This curriculum guide in literature, developed as part of a total English curriculum for pre-kindergarten through grade 10, suggests that students can best understand literature by recognizing its internal forms (i.e., characteristics that recur in settings, characters, and narrative patterns). Materials cover (1) an overview for teachers on the…

  14. Apparatus for forming targets

    DOEpatents

    Woerner, Robert L.

    1980-01-01

    Apparatus and method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

  15. Method for forming targets

    DOEpatents

    Woerner, Robert L.

    1979-01-01

    Method for cryoinduced uniform deposition of cryogenic materials, such as deuterium-tritium (DT) mixtures, on the inner surface of hollow spherical members, such as inertially imploded targets. By vaporizing and quickly refreezing cryogenic materials contained within a hollow spherical member, a uniform layer of the materials is formed on the inner surface of the spherical member. Heating of the cryogenic material, located within a non-isothermal compact freezing cell, is accomplished by an electrical heat pulse, whereafter the material is quickly frozen forming a uniform layer on the inner surface of the spherical member. The method is not restricted to producing a frozen layer on only the inner surface of the innermost hollow member, but where multiple concentric hollow spheres are involved, such as in multiple shell targets for lasers, electron beams, etc., layers of cryogenic material may also be formed on the inner surface of intermediate or outer spherical members, thus providing the capability of forming targets having multiple concentric layers or shells of frozen DT.

  16. Inelastic Scattering Form Factors

    Energy Science and Technology Software Center (ESTSC)

    1992-01-01

    ATHENA-IV computes form factors for inelastic scattering calculations, using single-particle wave functions that are eigenstates of motion in either a Woods-Saxon potential well or a harmonic oscillator well. Two-body forces of Gauss, Coulomb, Yukawa, and a sum of cut-off Yukawa radial dependences are available.

  17. Forms of Soft Sculpture

    ERIC Educational Resources Information Center

    Tucker, Dorothy

    1978-01-01

    For the past several years, students at Madison Senior High School in San Diego have responded to the tactile texture and draping quality of soft materials. They experimented enthusiastically with three-dimensional forms made out of foam rubber. Here is the result of their efforts and experimentation. (Author/RK)

  18. High energy forming facility

    NASA Technical Reports Server (NTRS)

    Ciurlionis, B.

    1967-01-01

    Watertight, high-explosive forming facility, 25 feet in diameter and 15 feet deep, withstands repeated explosions of 10 pounds of TNT equivalent. The shell is fabricated of high strength steel and allows various structural elements to deform or move elastically and independently while retaining structural integrity.

  19. Many Forms of Culture

    ERIC Educational Resources Information Center

    Cohen, Adam B.

    2009-01-01

    Psychologists interested in culture have focused primarily on East-West differences in individualism-collectivism, or independent-interdependent self-construal. As important as this dimension is, there are many other forms of culture with many dimensions of cultural variability. Selecting from among the many understudied cultures in psychology,…

  20. Formed photovoltaic module busbars

    DOEpatents

    Rose, Douglas; Daroczi, Shan; Phu, Thomas

    2015-11-10

    A cell connection piece for a photovoltaic module is disclosed herein. The cell connection piece includes an interconnect bus, a plurality of bus tabs unitarily formed with the interconnect bus, and a terminal bus coupled with the interconnect bus. The plurality of bus tabs extend from the interconnect bus. The terminal bus includes a non-linear portion.

  1. Geodiversity and land form

    NASA Astrophysics Data System (ADS)

    Gray, Murray

    2014-05-01

    The Earth's surface has a dynamic and topographically varied natural landscape. In some cases the resulting landforms are given generic names reflecting their form and/or origin, (e.g. sand dunes, eskers, ox-bow lakes) but in many cases the land surface has a more amorphous form and is less easily categorized other than at a landscape scale (e.g. dissected plateau, Chalk downland). Across much of Europe, while the natural vegetation has been removed or radically modified, the natural land form/topography remains in tact. In this context and in terms of geoconservation we ought to be: • allowing the dynamic natural processes that create, carve and modify landscapes to continue to operate; and • retaining natural topographic character and geomorphological authenticity in the face of human actions seeking to remodel the land surface. In this presentation examples of this approach to geoconservation of land form will be given from the UK and other parts of the world. This will include examples of both appropriate and inappropriate topographic modifications.

  2. Relevance of weak intermolecular forces on the supramolecular structure of free or DMSO solvated 5-(4-X-benzylidene)rhodanines (X = F, Cl, Br, I)

    NASA Astrophysics Data System (ADS)

    Casas, José S.; Castaño, M. Victoria; Couce, María D.; Sánchez, Agustín; Sordo, José; Torres, M. Dolores; Vázquez, Saulo A.; Vázquez-López, Ezequiel M.

    2016-09-01

    The rhodanines of the title (Xp-Rhod, X = F, Cl, Br, I) were synthesized and characterized in solid state and in solution. The crystal structures of the four compounds show different supramolecular organizations. In the F-, Cl- and Br-derivatives, a R22(8) (CSNH)2 ring forms via Nsbnd H⋯S hydrogen bonds between two neighbouring molecules to give dimers. The I-derivative is also dimeric, but exhibits R22(8) (CONH)2 rings. The two type of dimers are associated in a variety of structures through hydrogen bonding, π-stacking, Csbnd H⋯π interactions and halogen bonding. These interactions were analysed from a crystallographic point of view and their relative relevance was explored using DFT calculations. The effect produced on all these interactions by the incorporation of DMSO molecules to the lattice was analysed by comparing the crystal structures of Xp-Rhod compounds and those of corresponding Xp-RhodṡDMSO solvates.

  3. Waste-form development

    SciTech Connect

    Neilson, R.M. Jr.; Colombo, P.

    1982-01-01

    Contemporary solidification agents are being investigated relative to their applications to major fuel cycle and non-fuel cycle low-level waste (LLW) streams. Work is being conducted to determine the range of conditions under which these solidification agents can be applied to specific LLW streams. These studies are directed primarily towards defining operating parameters for both improved solidification of problem wastes and solidification of new LLW streams generated from advanced volume reduction technologies. Work is being conducted to measure relevant waste form properties. These data will be compiled and evaluated to demonstrate compliance with waste form performance and shallow land burial acceptance criteria and transportation requirements (both as they exist and as they are modified with time).

  4. Formed HIP Can Processing

    SciTech Connect

    Clarke, Kester Diederik

    2015-07-27

    The intent of this report is to document a procedure used at LANL for HIP bonding aluminum cladding to U-10Mo fuel foils using a formed HIP can for the Domestic Reactor Conversion program in the NNSA Office of Material, Management and Minimization, and provide some details that may not have been published elsewhere. The HIP process is based on the procedures that have been used to develop the formed HIP can process, including the baseline process developed at Idaho National Laboratory (INL). The HIP bonding cladding process development is summarized in the listed references. Further iterations with Babcock & Wilcox (B&W) to refine the process to meet production and facility requirements is expected.

  5. Nucleon Electromagnetic Form Factors

    SciTech Connect

    Kees de Jager

    2004-08-01

    Although nucleons account for nearly all the visible mass in the universe, they have a complicated structure that is still incompletely understood. The first indication that nucleons have an internal structure, was the measurement of the proton magnetic moment by Frisch and Stern (1933) which revealed a large deviation from the value expected for a point-like Dirac particle. The investigation of the spatial structure of the nucleon, resulting in the first quantitative measurement of the proton charge radius, was initiated by the HEPL (Stanford) experiments in the 1950s, for which Hofstadter was awarded the 1961 Nobel prize. The first indication of a non-zero neutron charge distribution was obtained by scattering thermal neutrons off atomic electrons. The recent revival of its experimental study through the operational implementation of novel instrumentation has instigated a strong theoretical interest. Nucleon electro-magnetic form factors (EMFFs) are optimally studied through the exchange of a virtual photon, in elastic electron-nucleon scattering. The momentum transferred to the nucleon by the virtual photon can be selected to probe different scales of the nucleon, from integral properties such as the charge radius to scaling properties of its internal constituents. Polarization instrumentation, polarized beams and targets, and the measurement of the polarization of the recoiling nucleon have been essential in the accurate separation of the charge and magnetic form factors and in studies of the elusive neutron charge form factor.

  6. Electromagnetic pion form factor

    SciTech Connect

    Roberts, C.D.

    1995-08-01

    A phenomenological Dyson-Schwinger/Bethe-Salpeter equation approach to QCD, formalized in terms of a QCD-based model field theory, the Global Color-symmetry Model (GCM), was used to calculate the generalized impulse approximation contribution to the electromagnetic pion form factor at space-like q{sup 2} on the domain [0,10] GeV{sup 2}. In effective field theories this form factor is sometimes understood as simply being due to Vector Meson Dominance (VMD) but this does not allow for a simple connection with QCD where the VMD contribution is of higher order than that of the quark core. In the GCM the pion is treated as a composite bound state of a confined quark and antiquark interacting via the exchange of colored vector-bosons. A direct study of the quark core contribution is made, using a quark propagator that manifests the large space-like-q{sup 2} properties of QCD, parameterizes the infrared behavior and incorporates confinement. It is shown that the few parameters which characterize the infrared form of the quark propagator may be chosen so as to yield excellent agreement with the available data. In doing this one directly relates experimental observables to properties of QCD at small space-like-q{sup 2}. The incorporation of confinement eliminates endpoint and pinch singularities in the calculation of F{sub {pi}}(q{sup 2}). With asymptotic freedom manifest in the dressed quark propagator the calculation yields q{sup 4}F{sub {pi}}(q{sup 2}) = constant, up to [q{sup 2}]- corrections, for space-like-q{sup 2} {approx_gt} 35 GeV{sup 2}, which indicates that soft, nonperturbative contributions dominate the form factor at presently accessible q{sup 2}. This means that the often-used factorization Ansatz fails in this exclusive process. A paper describing this work was submitted for publication. In addition, these results formed the basis for an invited presentation at a workshop on chiral dynamics and will be published in the proceedings.

  7. Space form of motionsickness

    NASA Technical Reports Server (NTRS)

    Komendantov, G. L.; Kopanev, V. I.

    1975-01-01

    Spacesickness under weightlessness conditions is explained mainly by disruption of the activity of the functional system perceiving space and participating in carrying out the balancing function, consisting, in particular, of the vestibular, proprioceptive, interoceptive, visual and cutaneomechanical analyzers. It can be assumed that, under specific conditions, Coriolis acceleration also is a cause of spacesickness. Adaptation is possible by formation of a new functional system which is adequate to the new mechanical conditions of weightlessness. Selection, training, creation of optimum conditions in the spacecraft cabin, medicinal, and technical improvement of spacecraft play an important role in prophylaxis of the space form of seasickness.

  8. Nucleon elastic form factors

    SciTech Connect

    D. Day

    2007-03-01

    The nucleon form factors are still the subject of active investigation even after an experimental effort spanning 50 years. This is because they are of critical importance to our understanding of the electromagnetic properties of nuclei and provide a unique testing ground for QCD motivated models of nucleon structure. Progress in polarized beams, polarized targets and recoil polarimetry have allowed an important and precise set of data to be collected over the last decade. I will review the experimental status of elastic electron scattering from the nucleon along with an outlook for future progress.

  9. GlassForm

    Energy Science and Technology Software Center (ESTSC)

    2011-09-16

    GlassForm is a software tool for generating preliminary waste glass formulas for a given waste stream. The software is useful because it reduces the number of verification melts required to develop a suitable additive composition. The software includes property models that calculate glass properties of interest from the chemical composition of the waste glass. The software includes property models for glass viscosity, electrical conductivity, glass transition temperature, and leach resistance as measured by the 7-daymore » product consistency test (PCT).« less

  10. Spun Almost Normal Form

    NASA Astrophysics Data System (ADS)

    Paullin, Katherine L.

    Many of a 3-manifold's properties are determined by the surfaces they contain, and this knowledge leads to the foundation of decision algorithms for 3- manifolds. Popular work influencing the work of 3-manifold algorithms has it's roots in normal surface theory. In a triangulated 3-manifold, Haken and Kneser showed that we could put any incompressible surface into normal form. Expanding on those techniques, Rubinstein and Stocking later showed we could put any strongly irreducible surface into almost normal form. Walsh has more recently shown that in an ideal triangulation of a hyperbolic manifold many surfaces can be spun normalized. One unsolved problem in 3-manifold algorithms is studying the complexity of Lens Space Recognition. Spun almost normalization appears to be a part of solving this larger problem. In this dissertation, I will first discuss a nontraditional technique using graphs of equivalence classes of compressing disks that allows us to take a combinatorial approach to generalize the result of Walsh's to nonhyperbolic manifolds. Using that method, I'll also explore the conditions needed to show that a surface can be spun almost normalized.