Science.gov

Sample records for 50ka dc-current interruption

  1. Current Zero Missing Phenomena caused by D.C. Current which Flows from Shunt Reactor at the Ground Fault and its Interruption

    NASA Astrophysics Data System (ADS)

    Kobayashi, Takayuki; Eto, Atsushi; Koshizuka, Tadashi; Nishiwaki, Susumu; Kudo, Kietsu; Matsushita, Kozo; Hosokawa, Osamu

    At substations where shunt reactors are installed, when a ground fault occurs near the reactor, d.c. current flows from the reactor to the fault point. There are cases where circuit breakers installed near the reactor interrupt only the d.c. current from the reactor with long arcing times. In those cases, attention should be paid to the damage of the contacts. This paper shows the investigation of the d.c. current interrupting performance for the 550kV one-break SF6 gas circuit breaker. In the range of some hundreds amperes, the d.c. arc voltages with long arcing times of the 550kV one-break circuit breaker were measured. The d.c. current waveform and arcing time at the d.c. current interruption by 550kV one-break circuit breaker in the 500kV cable system were calculated. Interrupting test circuit for the d.c. current interruption was constructed in the high power laboratory. From the interrupting test results, it was made clear that the circuit breaker had a good interrupting performance after the d.c. current interruptions.

  2. DC current monitor

    NASA Technical Reports Server (NTRS)

    Canter, Stanley (Inventor)

    1991-01-01

    A non-intrusive DC current monitor is presented which emulates the theoretical operation of an AC transformer. A conductor, carrying the current to be measured, acts as the primary of a DC current transformer. This current is passed through the center of a secondary coil, and core positioned thereabout, and produces a magnetic flux which induces a current in the secondary proportional to the current flowing in the primary. Means are provided to periodically reset the transformer core such that the measurement inaccuracies associated with core saturation are obviated. A reset current is caused to periodically flow through the secondary coil which produces a magnetic flux oppositely polarized to the flux created by the current in the primary, thus allowing ongoing measurements to be made.

  3. A ˜50 ka record of monsoonal variability in the Darjeeling foothill region, eastern Himalayas

    NASA Astrophysics Data System (ADS)

    Ghosh, Ruby; Bera, Subir; Sarkar, Anindya; Paruya, Dipak Kumar; Yao, Yi-Feng; Li, Cheng-Sen

    2015-04-01

    Pollen, phytoliths and δ 13C signatures of soil organic matter from two fluvial sedimentary sequences of the Darjeeling foothill region, eastern Himalayas are used to portray palaeoclimatic oscillations and their impact on regional plant communities over the last ˜50 ka. Quantitative palaeoclimate estimation using coexistence approach on pollen data and other proxies indicate significant oscillations in precipitation during the late part of MIS 3 (46.4-25.9 ka), early and middle part of MIS 2 (25.9-15.6 ka), and 5.4 to 3.5 ka. Middle to late MIS 3 (ca 46.4-31 ka.) was characterized by a comparatively low monsoonal activity and slightly higher temperature than that during ca 31 ka onwards. Simultaneous expansion of deciduous trees and chloridoid grasses also imply a drier and warmer phase. Between 31 and 22.3 ka (late MIS 3 to mid-MIS 2), higher precipitation and a slightly cooler temperature led to an increase in evergreen elements over deciduous taxa and wet-loving panicoid grasses over dry-loving chloridoid grasses than earlier. After ca 22.3 ka, shrinking of forest cover, expansion of C4 chloridoid grasses, Asteraceae and Cheno-ams in the vegetation with lowering of temperature and precipitation characterized the onset of the LGM which continued till 18.3 ka. End of the LGM is manifested by a restoration in the forest cover and in the temperature and precipitation regime. Later, during 5.4 to 4.3 ka, a strong monsoonal activity supported a dense moist evergreen forest cover that subsequently declined during 4.3 to 3.5 ka. A further increase in deciduous elements and non-arboreals might be a consequence of reduced precipitation and higher temperature during this phase. A comparison between monsoonal rainfall, MAT and palaeoatmospheric CO2 with floral dynamics since last ˜50 ka indicates that these fluctuations in plant succession were mainly driven by monsoonal variations.

  4. 14C ages and activity for the past 50 ka at Volcán Galeras, Colombia

    USGS Publications Warehouse

    Banks, N.G.; Calvache, V.M.L.; Williams, S.N.

    1997-01-01

    Volcán Galeras is the southernmost Colombian volcano with well-recorded historic activity. The volcano is part of a large and complex volcanic center upon which 400,000 people live. Historic activity has centered on a small-volume cone inside the youngest of several large amphitheaters that breach the west flank of the volcano, away from the city of Pasto (population 300,000). Lava flows (SiO2 between 54.6 and 64.7 wt.%) have dominated activity for more than 1 Ma, but explosive events have also occurred. Joint studies by volcanologists from Colombia, Ecuador, Peru, Bolivia, Argentina, and the United States produced 24 new14C ages and more than 100 stratigraphic sections to interpret the past 50 ka of activity at Galeras, including sector collapse events. The youngest collapse event truncated 12.8 ka lava flows and may have occurred as recently as 8 to 10 ka. Tephra-fall material rapidly thins and becomes finer away from the vent area. The only widespread marker in the < 10 ka section is a biotite-bearing tephra deposited between 4.1 and 4.5 ka from a source south of Galeras. It separates cryoturbated from largely undisturbed layers on Galeras, and thus dates a stratigraphic horizon which is useful in the interpretation of other volcanoes and geotectonics in the equatorial Andes. Pyroclastic flows during the past 50 ka have been small to moderate in volume, but they have left numerous thin deposits on the north and east flanks where lava flows have been impeded by crater and amphitheater walls. Many of the pyroclastic-flow deposits are lithic rich, with fines and clasts so strongly altered by hydrothermal action before eruption that they, as well as the sector collapse deposits, resemble waste dumps of leached cappings from disseminated sulfide deposits more than volcanogenic deposits. This evidence of a long-lived hydrothermal system indicates susceptibility to mass failure and explosive events higher than expected for a volcano built largely by lava flows and

  5. Eolian depositional phases during the past 50 ka and inferred climate variability for the Pampean Sand Sea, western Pampas, Argentina

    NASA Astrophysics Data System (ADS)

    Tripaldi, Alfonsina; Forman, Steven L.

    2016-05-01

    The Pampean Sand Sea, which occurs from the Argentinian Pampas to the eastern Andean piedmont, hosts presently stabilized dune fields spanning the late Quaternary. This study integrates previous results and presents new geomorphic, stratigraphic, sedimentological, and chronologic data for nineteen >2 m-thick eolian successions for the San Luis paleo-dune field, western Pampas, to better constrain the depositional history. Six eolian depositional phases are identified spanning the past 50 ka, interposed with paleosols and/or bounded by erosive surfaces. Age control was from 61 OSL ages of small aliquots of quartz grains from eolian stratigraphic units. The inferred timing of eolian phases are at ca. 70 ± 10 yr, 190 ± 20 yr, 12 to 1 ka, 22 to 17 ka, 29 to 24 ka, and 40 to 32 ka. A maximum span for periods of pedogenesis at ca. 12 to 17 ka, 22 to 24 ka, and 29 to 32 ka was provided by bounding OSL ages, which broadly overlap with high stands of pluvial lakes and glacier advances in the central Andes. We infer that the added precipitation may reflect expansion of the Southern Hemisphere monsoon, associated with Northern Hemisphere Heinrich events, leading to episodes of significantly wetter conditions (>350 mm MAP) to at least 35° S. Most of the Holocene (12 ka to 0.8 ka) was characterized by sand sheet deposit under drier than present conditions (100-450 mm MAP), associated with Monte-type vegetation (shrub steppe). The latest two eolian depositional phases, occurred at ca. 190 and 70 yr ago, during the historic period with European settlement and are related to anthropogenic landscape disturbance, though the youngest phase was concomitant with 1930s drought. Wet conditions dominated since ca. AD 1970 with new lakes and rivers forming across this eolian terrain; an incongruous environmental response in reference to drier conditions for most of the Holocene.

  6. Operation of the DC current transformer intensity monitors at FNAL during run II

    SciTech Connect

    Crisp, J.; Fellenz, B.; Heikkinen, D.; Ibrahim, M.A.; Meyer, T.; Vogel, G.; /Fermilab

    2012-01-01

    Circulating beam intensity measurements at FNAL are provided by five DC current transformers (DCCT), one per machine. With the exception of the DCCT in the Recycler, all DCCT systems were designed and built at FNAL. This paper presents an overview of both DCCT systems, including the sensor, the electronics, and the front-end instrumentation software, as well as their performance during Run II.

  7. Linking the10Be continental record of Lake Baikal to marine and ice archives of the last 50 ka: Implication for the global dust-aerosol input

    USGS Publications Warehouse

    Aldahan, A.; Possnert, G.; Peck, J.; King, J.; Colman, S.

    1999-01-01

    We present here a 10Be profile from the continental sediments of Lake Baikal (the world's largest fresh water lake), which, for the first time, shows the ??? 40 ka 10Be enhancement and a pattern that strongly matches those from the marine and ice records for the last 50 ka. This finding provides a new horizon for global and regional correlation of continental archives. Additionally, our VADM-predicted 10Be production confirms and further strengthens a common global cause (geomagnetic field intensity) for the change in atmospheric 10Be over the last 50 ka. We also show that most of the 10Be inventory to the lake has been provided by riverine input, but with a significant addition from direct precipitation and dust-aerosol fallout. We estimate a higher dust-aerosol contribution of 10Be during the Holocene and interstadial stage 3 (22-50 ka) as compared with the glacial period (12-22 ka). Copyright 1999 by the American Geophysical Union.

  8. PASADO - ICDP Deep Drilling at Laguna Potrok Aike (Argentina): A 50 ka Record of Increasing Environmental Dynamics

    NASA Astrophysics Data System (ADS)

    Zolitschka, Bernd; Anselmetti, Flavio; Ariztegui, Daniel; Francus, Pierre; Gebhardt, Catalina; Kliem, Annette Hahn Pierre; Lücke, Andreas; Ohlendorf, Christian; Schäbitz, Frank; Wastegard, Stefan

    2010-05-01

    . Such features either indicate an increased seismicity that cannot be completely excluded for this late Quaternary backarc volcanic field or they are the result of hydrologically induced lake level variations and hence relate to changes in hydrological conditions within the catchment area. Intercalated throughout the record are 24 macroscopically visible volcanic ash layers that document the regional volcanic history and open the possibility to establish an independent time control through tephrochronology supported by Ar/Ar dating. Moreover, these isochrones potentially act as links to marine sediment records from the South Atlantic and to Antarctic ice cores. Preliminary extrapolation of the mean sedimentation rate of 1.1 mm/a determined for the upper 16 ka indicates that a continuous and high quality record may go back in time to approximately 50 ka. A comparable time frame is supported by first radiocarbon dates obtained from aquatic mosses.

  9. Investigation of DC current injection effect on the microwave characteristics of HTS YBCO microstrip resonators

    NASA Astrophysics Data System (ADS)

    Nurgaliev, T.; Blagoev, B.; Mateev, E.; Neshkov, L.; Strbik, V.; Uspenskaya, L.; Nedkov, I.; Chromik, Š.

    2014-03-01

    The DC current injection effect from a ferromagnetic (FM) La0.7Sr0.3MnO3 (LSMO) to a high temperature superconducting (HTS) Y1Ba2Cu3O7-x (YBCO) thin film was investigated by the microwave surface impedance measurements in a FM/HTS structure, formed as a microstrip resonator for improving the sensitivity of the experiments. The quality factor and the resonance frequency of this structure were found to strongly depend on the current strength, injected from the LSMO electrode into the HTS microstrip electrode. The magnetic penetration depth and the quasiparticle conductivity of the HTS component were determined to increase under DC current injection process, which in all probability stimulated breaking of Cooper pairs and led to a decrease of the superfluid concentration and an increase of the normal fluid concentration without significantly affecting the relaxation time of the quasiparticles.

  10. Flight Checklists And Interruptions

    NASA Technical Reports Server (NTRS)

    Linde, C.; Goguen, J.

    1991-01-01

    Report examines relation between performances of flight checklists and interruptions. Based on study of simulated flights of Boeing 707 Airplane. During each flight series of overlapping problems introduced. Study investigated patterns of communication that in carrying out checklists, may contribute to accidents. Showed good crews had high continuity in following checklists and it is not number of interruptions but rather duration of interruptions associated with quality of performance. Suggests greater burden placed on memory by one long interruption than by several short ones.

  11. SIM regional comparison of ac-dc current transfer difference SIM.EM-K12

    NASA Astrophysics Data System (ADS)

    Di Lillo, Lucas

    2015-01-01

    The ac-dc current transfer difference identified as SIM.EM.K-12 began in July 2010 and was completed in September 2012. Six NMIs in the SIM region and one NMI in the AFRIMET region took part: NRC (Canada), NIST (United States of America), CENAM (Mexico), INTI (Argentina), UTE (Uruguay), INMETRO (Brazil) and NIS (Egypt). The comparisons were proposed to assess the measurement capabilities in ac-dc current transfer difference of the participants NMIs. The ac-dc current transfer differences of the travelling standard had been measured at 10 mA and 5 A at 10 Hz, 55 Hz, 1 kHz, 10 kHz, 20 kHz, 50 kHz and 100 kHz. The test points were selected to link the results with the equivalent CCEM Key Comparisons (CCEM-K12), through three NMIs participating in both SIM and CCEM key comparisons (INTI, NRC and NIST). The report shows the degree of equivalence in the SIM region and also the degree of equivalence with the corresponding CCEM reference value. The results of all participants support the values and uncertainties of the applicable CMC entries for ac-dc current transfer difference in the Key Comparison Database held at the BIPM. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  12. Low-voltage, wide-range, current-controlled DC current generator

    NASA Astrophysics Data System (ADS)

    Mathew, M.; Hart, B. L.; Hayatleh, K.; Lidgey, F. J.

    2011-08-01

    Operating from a 1 V rail supply, a proposed CMOS current-controlled DC current generator can function as a repeater, attenuator or amplifier over the input current range, 1 µA to 1 mA, with a current-transfer ratio accuracy better than 1% using IBM technology, characterised by a process with a 0.13 µm minimum feature size. In repeater mode, the incremental output resistance exceeds 30 MΩ for an output current of 500 µA at an output voltage of 0.20 V, and exceeds 1 MΩ for an output current of 1 mA at an output voltage of 0.22 V. For zero input current, the circuit dissipation is 117 µW.

  13. Multiprocessing interrupt arrangement

    SciTech Connect

    Brown, S.S.; Hunsberger, D.J.; Lundberg, M.R.

    1986-08-05

    An interrupt system is described for use with each processor of a multiprocessor communication or telephone network, where one processor may request actions of another responding processor independent of the state of the other processors. The system consists of: means including a FIFO memory for queuing interrupt vector messages directed from a requesting processor to a particular other responding processor and received via the network directly from the requesting processor without intervention by any other processor, and means controlled only by the responding processor for sequentially providing to the directed processor an interrupt signal for each of the queued vector message.

  14. Interruptions disrupt reading comprehension.

    PubMed

    Foroughi, Cyrus K; Werner, Nicole E; Barragán, Daniela; Boehm-Davis, Deborah A

    2015-06-01

    Previous research suggests that being interrupted while reading a text does not disrupt the later recognition or recall of information from that text. This research is used as support for Ericsson and Kintsch's (1995) long-term working memory (LT-WM) theory, which posits that disruptions while reading (e.g., interruptions) do not impair subsequent text comprehension. However, to fully comprehend a text, individuals may need to do more than recognize or recall information that has been presented in the text at a later time. Reading comprehension often requires individuals to connect and synthesize information across a text (e.g., successfully identifying complex topics such as themes and tones) and not just make a familiarity-based decision (i.e., recognition). The goal for this study was to determine whether interruptions while reading disrupt reading comprehension when the questions assessing comprehension require participants to connect and synthesize information across the passage. In Experiment 1, interruptions disrupted reading comprehension. In Experiment 2, interruptions disrupted reading comprehension but not recognition of information from the text. In Experiment 3, the addition of a 15-s time-out prior to the interruption successfully removed these negative effects. These data suggest that the time it takes to process the information needed to successfully comprehend text when reading is greater than that required for recognition. Any interference (e.g., an interruption) that occurs during the comprehension process may disrupt reading comprehension. This evidence supports the need for transient activation of information in working memory for successful text comprehension and does not support LT-WM theory. PMID:25867225

  15. Orbital and millennial-scale variability in the southernmost reaches of the South American summer monsoon during the last 50 ka BP

    NASA Astrophysics Data System (ADS)

    Chiessi, C. M.; Govin, A.; Mulitza, S.; Campos, M. D.

    2013-05-01

    The South American summer monsoon (SASM) and its related features (e.g., the South Atlantic Convergence Zone) deliver most of the precipitation for the Amazon and La Plata basins, the two largest drainage systems in South America. Marine, cave and lake records mainly from equatorial and tropical South America show that the strength of the SASM fluctuated on orbital and millennial time-scales, with a strong SASM during periods of high austral summer insolation. On millennial time-scales, precipitation in tropical South America to the south of the equator was increased during periods of a weak Atlantic meridional overturning circulation. Nevertheless, there is an almost complete lack of information about changes in precipitation in the subtropics and mid-latitudes of South America. This area comprises the transition from the southernmost reaches of the SASM to the semi-arid northern Patagonia, and is highly sensitive to changes in precipitation because: (i) it mainly receives precipitation during austral summer (related to the SASM); and (ii) it shows a steep gradient in total annual precipitation (going from ca. 1000 mm/yr around 30oS to ca. 200 mm/yr around 40oS). Here we present recently acquired data from the terrigenous fraction of marine sediment core GeoB6308-3 (39.30oS / 53.97oW / 3620 m water depth / 793 cm long) collected off southeastern South America. Our age model is based on 18 14C AMS ages while information about changes in continental climate comes from bulk sediment major element (i.e., Ca, Fe, Al, Si, Ti, K) proportions and Nd isotopes. The core recorded the last ca. 50 ka BP and its terrigenous sediment fraction shows a typical Central-West Argentinean / Patagonian isotopic signature. Through X-ray fluorescence scanning we were able to produce a record with mean temporal resolution of 35 yr. In our presentation, we will discuss changes in the southernmost reaches of the SASM and compare it to other records from South and Central America with the

  16. Miscarriage: A Dream Interrupted

    ERIC Educational Resources Information Center

    Trepal, Heather C.; Semivan, Suzanne Gibson; Caley-Bruce, Mary

    2005-01-01

    Pregnancy is a developmental task that requires women to become accustomed to inherent and sometimes profound biological, somatic, and psychological changes. When pregnancy is interrupted by miscarriage, it may become a pivotal crisis point in the development of a woman's maternal identity as well as an issue in family development. This manuscript…

  17. Impact of quasi-dc currents on three-phase distribution transformer installations

    SciTech Connect

    McConnell, B.W.; Barnes, P.R. ); Tesche, F.M. , Dallas, TX ); Schafer, D.A. )

    1992-06-01

    This report summarizes a series of tests designed to determine the response of quasi-dc currents on three-phase power distribution transformers for electric power systems. In general, if the dc injection is limited to the primary side of a step-down transformer, significant harmonic distortion is noted and an increase in the reactive power demand results. For dc injection on the secondary (load) side of the step-down transformer the harmonic content at the secondary side is quite high and saturation occurs with a relatively low level of dc injection; however, the reactive power demand is significantly lower. These tests produced no apparent damage to the transformers. Transformer damage is dependent on the duration of the dc excitation, the level of the excitation, and on thermal characteristics of the transfer. The transformer response time is found to be much shorter than seen in power transformer tests at lower dc injection levels. This shorter response time suggests that the response time is strongly dependent on the injected current levels, and that higher levels of dc injection for shorter durations could produce very high reactive power demands and harmonic distortion within a few tenths of a second. The added reactive power load could result in the blowing of fuses on the primary side of the transformer for even moderate dc injection levels, and neutral currents are quite large under even low-level dc injection. This smoking neutral'' results in high-level harmonic injection into equipment via the neutral and in possible equipment failure.

  18. Radiolaria and pollen records from 0 to 50 ka at ODP Site 1233: Continental and marine climate records from the Southeast Pacific

    USGS Publications Warehouse

    Pisias, N.G.; Heusser, L.; Heusser, C.; Hostetler, S.W.; Mix, A.C.; Weber, M.

    2006-01-01

    Site 1233 drilled during Leg 202 of the Ocean Drilling Program provides a detailed record of marine and continental climate change in the Southeast Pacific and South American continent. Splits from over 500 samples taken at 20 cm intervals for quantitative analysis of radiolarian and pollen populations yield a temporal resolution of 200-400 years. In each sample, 39 pollen taxa and 40 radiolarian species and genera were evaluated. Age control is provided by 25 AMS 14C dates [Lamy, F., Kaiser, J., Ninnemann, U., Hebbeln, D., Arz, H.W., Stoner, J., 2004. Science 304, 1959-1962]. Multivariate statistical analyses of these data allow us to conclude the following: (1) During the past 50 ka, the region of the central Chile coast is not directly influenced by polar water from the Antarctic region. (2) Changes in ocean conditions off central Chile during this time interval primarily reflect north-south shifts in the position of the South Pacific transition zone. (3) Changes in Chilean vegetation reflect comparable latitudinal shifts in precipitation and the position of the southern westerlies. (4) The first canonical variate of radiolarian and pollen records extracted from Site 1233 are remarkably similar to each other as well as to temperature records from the Antarctic, which suggests that marine and continental climate variability in the region is tightly coupled at periods longer than 3000 years. (5) The phase coupling of these climate records, which lead variations of continental erosion based on iron abundance at the same site, are consistent with a hypothesis that erosion is linked to relatively long (i.e, few thousand years) response times of the Patagonian ice sheet, and thus is not a direct indicator of regional climate. ?? 2005 Elsevier Ltd. All rights reserved.

  19. Adversary Sequence Interruption Model

    Energy Science and Technology Software Center (ESTSC)

    1985-11-15

    PC EASI is an IBM personal computer or PC-compatible version of an analytical technique for measuring the effectiveness of physical protection systems. PC EASI utilizes a methodology called Estimate of Adversary Sequence Interruption (EASI) which evaluates the probability of interruption (PI) for a given sequence of adversary tasks. Probability of interruption is defined as the probability that the response force will arrive before the adversary force has completed its task. The EASI methodology is amore » probabilistic approach that analytically evaluates basic functions of the physical security system (detection, assessment, communications, and delay) with respect to response time along a single adversary path. It is important that the most critical scenarios for each target be identified to ensure that vulnerabilities have not been overlooked. If the facility is not overly complex, this can be accomplished by examining all paths. If the facility is complex, a global model such as Safeguards Automated Facility Evaluation (SAFE) may be used to identify the most vulnerable paths. PC EASI is menu-driven with screen forms for entering and editing the basic scenarios. In addition to evaluating PI for the basic scenario, the sensitivities of many of the parameters chosen in the scenario can be analyzed. These sensitivities provide information to aid the analyst in determining the tradeoffs for reducing the probability of interruption. PC EASI runs under the Micro Data Base Systems'' proprietary database management system Knowledgeman. KMAN provides the user environment and file management for the specified basic scenarios, and KGRAPH the graphical output of the sensitivity calculations. This software is not included. Due to errors in release 2 of KMAN, PC EASI will not execute properly; release 1.07 of KMAN is required.« less

  20. A regional overview of the last glacial period in the temperate NE Atlantic: varying paleoproductivity centers over the last 50 ka BP

    NASA Astrophysics Data System (ADS)

    Penaud, Aurélie; Eynaud, Frédérique; Ganne, Axelle

    2015-04-01

    Recent palynological investigations carried out in the eastern Gulf of Cadiz (MD99-2339 core) over MIS 3 enable to consider dinoflagellate cyst assemblage patterns over the last 50 ka BP through a compilation of 6 cores from the NE subtropical Atlantic to the Northern Bay of Biscay (also including cores MD95-2042, MD95-2043, MD04-2805CQ, VK03-58bis). Dinocyst signals depict hydrological front latitudinal shifts over the last glacial and associated sea-surface consequences regarding past regimes of primary productivity. We show here new data clearly evidencing subtropical latitudes of Cadiz as being as productive areas over the last glacial as recorded today in the septentrional part of the Bay of Biscay, especially between GI 8 and GI 12. We especially focus on dinocyst-species Lingulodinium machaerophorum relative abundances and absolute concentrations that we first evidence as a powerful tool to reconstruct and discuss productivity shifts through time in the temperate North Atlantic. This spatio-temporal synthesis bring important evidences of fast migrating paleoproductiviy centers from the last glacial period to present, implying also large consequences on the biological pump through time. Regarding this specific session, 5 of the 6 cores discussed here were retrieved by the R/V Marion Dufresne through 3 different cruises: Core MD99-2339 (35.89°N, 7.53°W, 1170m water depth, 18.54m long) was retrieved in a contouritic field in the oriental part of the Gulf of Cadiz by the oceanographic R/V Marion Dufresne during the 1999 International Marine Global Change Studies V (IMAGES V) cruise (Labeyrie, Jansen and Cortijo, 2003). Cores MD95-2042 (37°48'N, 10°10'W, 3146m water depth, 39.56m long) and MD95-2043 (36°8.6'N, 2°37.3'W, 1841m water depth, 36m long) were retrieved from the SW Iberian margin and the central Alboran Sea, respectively, by the oceanographic R/V Marion Dufresne during the 1995 IMAGES I cruise (Bassinot and Labeyrie, 1996). Core MD04-2805 CQ (34

  1. Large reduction of the depinning field for a transverse domain wall under application of rf and dc currents

    NASA Astrophysics Data System (ADS)

    Metaxas, P. J.; Anane, A.; Cros, V.; Grollier, J.; Deranlot, C.; Petroff, F.; Fert, A.; Ulysse, C.; Faini, G.

    2010-03-01

    A new generation of proposed spintronic devices are based on domain wall (DW) motion (DW-MRAM, DW logic, racetrack memory...). However, reliable depinning of domain walls remains elusive, especially in zero field. Here, we have studied the combined effect of rf and dc currents on the depinning of transverse walls in the soft NiFe layer of a 100 nm wide Co/Cu/NiFe spin valve wire. Using the GMR effect, we ensure that the domain wall is always prepared at the same intrinsic defect and then measure the depinning field for different applied dc and rf currents. Notably, for a narrow range of rf frequencies at around 3GHz, we evidence a strong reduction in the depinning field (from ˜80 Oe to ˜30 Oe). Our results are suggestive of a very efficient resonant depinning effect in our spin valve wire which depends not only on the rf power but also on the polarity and amplitude of the accompanying dc current.

  2. Global interrupt and barrier networks

    DOEpatents

    Blumrich, Matthias A.; Chen, Dong; Coteus, Paul W.; Gara, Alan G.; Giampapa, Mark E; Heidelberger, Philip; Kopcsay, Gerard V.; Steinmacher-Burow, Burkhard D.; Takken, Todd E.

    2008-10-28

    A system and method for generating global asynchronous signals in a computing structure. Particularly, a global interrupt and barrier network is implemented that implements logic for generating global interrupt and barrier signals for controlling global asynchronous operations performed by processing elements at selected processing nodes of a computing structure in accordance with a processing algorithm; and includes the physical interconnecting of the processing nodes for communicating the global interrupt and barrier signals to the elements via low-latency paths. The global asynchronous signals respectively initiate interrupt and barrier operations at the processing nodes at times selected for optimizing performance of the processing algorithms. In one embodiment, the global interrupt and barrier network is implemented in a scalable, massively parallel supercomputing device structure comprising a plurality of processing nodes interconnected by multiple independent networks, with each node including one or more processing elements for performing computation or communication activity as required when performing parallel algorithm operations. One multiple independent network includes a global tree network for enabling high-speed global tree communications among global tree network nodes or sub-trees thereof. The global interrupt and barrier network may operate in parallel with the global tree network for providing global asynchronous sideband signals.

  3. Oceanic density fronts steering bottom-current induced sedimentation deduced from a 50 ka contourite-drift record and numerical modeling (off NW Spain)

    NASA Astrophysics Data System (ADS)

    Hanebuth, Till J. J.; Zhang, Wenyan; Hofmann, Antonia L.; Löwemark, Ludvig A.; Schwenk, Tilmann

    2015-03-01

    How the various bottom-near hydrographic and sedimentary processes control the formation of contourite drifts, i.e. of bottom-current related confined deep-sea depocenters, usually remains widely speculative. This study uses a transect of six sediment cores and a sediment echosounder profile across a whole contourite system off NW Spain to address the sediment dynamics responsible for the depositional pattern. This "mounded patch"-type contourite drift (18 km long, 20 km wide) with a 150-m deep channel (moat) has formed around an 800-m high structural obstacle. Deposition on the contourite drift in the past was characterized by alternating calm and high-energy bottom-flow conditions. Calm conditions (Last Glacial period: 27-17 cal ka BP; late Holocene times: <4 cal ka BP) led to slightly current-influenced deposition of fine-grained sediments (10 μm) in the entire basin. This regime was interrupted by periods of short-lasting waxing-and-waning high-energy conditions (D/O events during Marine Isotope Stage 3; the Deglacial/early Holocene time interval at 17-4 cal ka BP), resulting in the deposition of coarse sediments (70 μm). Process-based numerical modeling demonstrates that pulse-like oceanic density fronts traveling within the transition zone of two water masses (Labrador Sea Water, Mediterranean Outflow Water) provide a powerful mechanism for contouritic deposition, rather than the core of a water mass itself. These gravity-driven density fronts lead to local re-suspension of sands stored inside the drift's moat and to subsequent upward transport towards the drift's crest. Here, the oceanic density fronts produce additional km-scale eddies. These migrating eddies provide an efficient mechanism for further widespread sediment re-distribution. In comparison with paleoceanographic reconstructions, a downward migration or expansion of the Mediterranean Outflow Water by about 300 m led most probably to such temporary contouritic sand deposition. We finally propose

  4. An architecture for intelligent task interruption

    NASA Technical Reports Server (NTRS)

    Sharma, D. D.; Narayan, Srini

    1990-01-01

    In the design of real time systems the capability for task interruption is often considered essential. The problem of task interruption in knowledge-based domains is examined. It is proposed that task interruption can be often avoided by using appropriate functional architectures and knowledge engineering principles. Situations for which task interruption is indispensable, a preliminary architecture based on priority hierarchies is described.

  5. Perceptual Learning of Interrupted Speech

    PubMed Central

    Benard, Michel Ruben; Başkent, Deniz

    2013-01-01

    The intelligibility of periodically interrupted speech improves once the silent gaps are filled with noise bursts. This improvement has been attributed to phonemic restoration, a top-down repair mechanism that helps intelligibility of degraded speech in daily life. Two hypotheses were investigated using perceptual learning of interrupted speech. If different cognitive processes played a role in restoring interrupted speech with and without filler noise, the two forms of speech would be learned at different rates and with different perceived mental effort. If the restoration benefit were an artificial outcome of using the ecologically invalid stimulus of speech with silent gaps, this benefit would diminish with training. Two groups of normal-hearing listeners were trained, one with interrupted sentences with the filler noise, and the other without. Feedback was provided with the auditory playback of the unprocessed and processed sentences, as well as the visual display of the sentence text. Training increased the overall performance significantly, however restoration benefit did not diminish. The increase in intelligibility and the decrease in perceived mental effort were relatively similar between the groups, implying similar cognitive mechanisms for the restoration of the two types of interruptions. Training effects were generalizable, as both groups improved their performance also with the other form of speech than that they were trained with, and retainable. Due to null results and relatively small number of participants (10 per group), further research is needed to more confidently draw conclusions. Nevertheless, training with interrupted speech seems to be effective, stimulating participants to more actively and efficiently use the top-down restoration. This finding further implies the potential of this training approach as a rehabilitative tool for hearing-impaired/elderly populations. PMID:23469266

  6. Spin-Hall-Effect-Assisted Electroresistance in Antiferromagnets via 105 A/cm2 dc Current

    PubMed Central

    Han, Jiahao; Wang, Yuyan; Pan, Feng; Song, Cheng

    2016-01-01

    Antiferromagnet (AFM) spintronics with reduced electrical current is greatly expected to process information with high integration and low power consumption. In Pt/FeMn and Ta/FeMn hybrids, we observe significant resistance variation (up to 7% of the total resistance) manipulated by 105 A/cm2 dc current. We have excluded the contribution of isotropic structural effects, and confirmed the critical role of the spin Hall injection from Pt (or Ta) to FeMn. This electrical current-manipulated resistance (i.e. electroresistance) is proposed to be attributed to the spin-Hall-effect-induced spin-orbit torque in FeMn. Similar results have also been detected in plain IrMn films, where the charge current generates spin current via the spin Hall effect with the existence of Ir atoms. All the measurements are free from external magnetic fields and ferromagnets. Our findings present an interesting step towards high-efficiency spintronic devices. PMID:27546199

  7. Spin-Hall-Effect-Assisted Electroresistance in Antiferromagnets via 10(5) A/cm(2) dc Current.

    PubMed

    Han, Jiahao; Wang, Yuyan; Pan, Feng; Song, Cheng

    2016-01-01

    Antiferromagnet (AFM) spintronics with reduced electrical current is greatly expected to process information with high integration and low power consumption. In Pt/FeMn and Ta/FeMn hybrids, we observe significant resistance variation (up to 7% of the total resistance) manipulated by 10(5) A/cm(2) dc current. We have excluded the contribution of isotropic structural effects, and confirmed the critical role of the spin Hall injection from Pt (or Ta) to FeMn. This electrical current-manipulated resistance (i.e. electroresistance) is proposed to be attributed to the spin-Hall-effect-induced spin-orbit torque in FeMn. Similar results have also been detected in plain IrMn films, where the charge current generates spin current via the spin Hall effect with the existence of Ir atoms. All the measurements are free from external magnetic fields and ferromagnets. Our findings present an interesting step towards high-efficiency spintronic devices. PMID:27546199

  8. Phase response curve for the ultradian rhythm of the lateral leaflets of Desmodium gyrans using DC current pulses.

    PubMed

    Sharma, V K; Jensen, C; Johnsson, A

    2001-01-01

    In the present study the leaf movement rhythm was perturbed by the application of DC current pulses (15 microA, 10 seconds, voltage applied: 10 V) to the upper part of the pulvinus, passing through the pulvinus and its stalk. The pulses were applied at four different positions of the leaflets: when the leaves were at the lowermost position, when moving up, at the uppermost position and when moving down. The pre-perturbed and the post-perturbed rhythms were compared. We found that the rhythms were shifted in phase and the phase shifts observed at the four different positions of the leaflets were significantly different in magnitude as well as direction. Furthermore, we could also observe phase advances, which is in contrast to an earlier finding. A phase response curve (PRC) was constructed to illustrate the sensitivity of the oscillating leaflet system to DC pulses. Substantial delays of about 50 s (as compared to the period of about 200 s) were obtained when pulses were administered at the lowermost position and when leaflet were moving upwards, while advances or no phase shifts were recorded in the uppermost position and when leaflet were moving down respectively. PMID:11302218

  9. Impact of quasi-dc currents on three-phase distribution transformer installations. Power Systems Technology Program

    SciTech Connect

    McConnell, B.W.; Barnes, P.R.; Tesche, F.M.; Schafer, D.A.

    1992-06-01

    This report summarizes a series of tests designed to determine the response of quasi-dc currents on three-phase power distribution transformers for electric power systems. In general, if the dc injection is limited to the primary side of a step-down transformer, significant harmonic distortion is noted and an increase in the reactive power demand results. For dc injection on the secondary (load) side of the step-down transformer the harmonic content at the secondary side is quite high and saturation occurs with a relatively low level of dc injection; however, the reactive power demand is significantly lower. These tests produced no apparent damage to the transformers. Transformer damage is dependent on the duration of the dc excitation, the level of the excitation, and on thermal characteristics of the transfer. The transformer response time is found to be much shorter than seen in power transformer tests at lower dc injection levels. This shorter response time suggests that the response time is strongly dependent on the injected current levels, and that higher levels of dc injection for shorter durations could produce very high reactive power demands and harmonic distortion within a few tenths of a second. The added reactive power load could result in the blowing of fuses on the primary side of the transformer for even moderate dc injection levels, and neutral currents are quite large under even low-level dc injection. This ``smoking neutral`` results in high-level harmonic injection into equipment via the neutral and in possible equipment failure.

  10. Investigating Interruptions: Implications for Flightdeck Performance

    NASA Technical Reports Server (NTRS)

    Latorella, Kara A.

    1999-01-01

    A fundamental aspect of multiple task management is attending to new stimuli and integrating associated task requirements into an ongoing task set; this is "interruption management" (IM). Anecdotal evidence and field studies indicate the frequency and consequences of interruptions, however experimental investigations of mechanisms influencing IM are scarce. Interruptions on commercial flightdecks are numerous, of various forms, and have been cited as contributing factors in many aviation incident and accident reports. This research grounds an experimental investigation of flightdeck interruptions in a proposed IM stage model. This model organizes basic research, identifies influencing mechanisms, and suggests appropriate dependent measures for IM. Fourteen airline pilots participated in a flightdeck simulation experiment to investigate the general effects of performing an interrupting task and interrupted procedure, and the effects of specific task factors: (1) modality; (2) embeddedness, or goal-level, of an interruption; (3) strength of association, or coupling-strength, between interrupted tasks; (4) semantic similarity; and (5) environmental stress. General effects of interruptions were extremely robust. All individual task factors significantly affected interruption management, except "similarity." Results extend the Interruption Management model, and are interpreted for their implications for interrupted flightdeck performance and intervention strategies for mitigating their effects on the flightdeck.

  11. Microwave polarization angle study of the radiation-induced magnetoresistance oscillations in the GaAs/AlGaAs 2D electron system under dc current bias

    NASA Astrophysics Data System (ADS)

    Iqbal, Muhammad-Zahir; Liu, Han-Chun; Heimbeck, Martin S.; Everitt, Henry O.; Wegscheider, Werner; Mani, Ramesh G.

    Microwave-induced magnetoresistance oscillations followed by the vanishing resistance states are a prime representation of non-equilibrium transport phenomena in two-dimensional electron systems (2DES). The effect of a dc current bias on the nonlinear response of 2DES with microwave polarization angle under magnetic field is a subject of interest. Here, we have studied the effect of various dc current bias on microwave radiation-induced magnetoresistance oscillations in a high mobility 2DES. Further, we systematically investigate the effect of the microwave polarization angle on the magneto-resistance oscillations at two different frequencies 152.78 GHz and 185.76 GHz. This study aims to better understand the effects of both dc current and microwave polarization angle in the GaAs/AlGaAs system, both of which modify the observed magneto-transport properties DOE-BES, Mat'l. Sci. & Eng. Div., DE-SC0001762; ARO W911NF-14-2-0076; ARO W911NF-15-1-0433.

  12. Executing application function calls in response to an interrupt

    SciTech Connect

    Almasi, Gheorghe; Archer, Charles J.; Giampapa, Mark E.; Gooding, Thomas M.; Heidelberger, Philip; Parker, Jeffrey J.

    2010-05-11

    Executing application function calls in response to an interrupt including creating a thread; receiving an interrupt having an interrupt type; determining whether a value of a semaphore represents that interrupts are disabled; if the value of the semaphore represents that interrupts are not disabled: calling, by the thread, one or more preconfigured functions in dependence upon the interrupt type of the interrupt; yielding the thread; and if the value of the semaphore represents that interrupts are disabled: setting the value of the semaphore to represent to a kernel that interrupts are hard-disabled; and hard-disabling interrupts at the kernel.

  13. Interruptions as an Index of Communication Dominance.

    ERIC Educational Resources Information Center

    Camden, Carl; Kennedy, Carole

    A study was conducted to examine speech interruption patterns as an index of communication dominance and gender differences in language behavior. Six graduate student groups involving a total of 35 subjects were videotaped. The data extracted for study were 255 transcribed interruption sequences. A category system was developed and used to code…

  14. Opportunistic Interruptions: Interactional Vulnerabilities Deriving from Linearization

    ERIC Educational Resources Information Center

    Gibson, David R.

    2005-01-01

    Speaking involves "linearizing" a message into a string of words. This process leaves us vulnerable to being interrupted in such a way that the aborted turn is a misrepresentation of the intended message. Further, because we linearize our messages in standard ways, we are recurrently vulnerable to interruptions at particular turn-construction…

  15. Production inventory with service time and interruptions

    NASA Astrophysics Data System (ADS)

    Krishnamoorthy, A.; Nair, Sajeev S.; Narayanan, Viswanath C.

    2015-07-01

    This paper considers an (s,S) production inventory system with positive service time, with time for producing each item following Erlang distribution. Customers arrive according to a Poisson process. A customer who arrives when there is no inventory in the system is considered lost. On the other hand, a customer who finds a busy server with at least one inventory in the system joins a queue of infinite capacity. When the inventory level falls to s, production process is switched on, and it is switched off when the inventory level reaches back to S. Service time to each customer also follows an Erlang distribution. The service of a customer may be interrupted, where the time for such a phenomenon follows an exponential distribution, whenever it occurs. An interrupted service, after repair, resumes from where it was stopped. The correction/repair time follows an exponential distribution. We assume that the service of a single customer may encounter any number of interruptions and that the customer being served waits there until his service is completed. Moreover, at a time the server is subject to at most one interruption. We also assume that no inventory is lost due to a service interruption. Like the service process, the production process also is subject to interruptions, where the duration to an interruption follows an exponential distribution. However, in contrast to the service interruption, in the case of interruption to production process, we assume that the item being processed is lost because of interruption. That is, the production process, on being interrupted, restarts from the beginning, after repair. The repair time of an interrupted production process follows exponential distribution. Few of the last service phases are assumed to be protected in the sense that the service will not be interrupted while being in these phases. The same is assumed for the production process also. The model is analysed as a level-independent quasi-birth-death process. We

  16. Control algorithm for the inverter fed induction motor drive with DC current feedback loop based on principles of the vector control

    SciTech Connect

    Vuckovic, V.; Vukosavic, S. )

    1992-01-01

    This paper brings out a control algorithm for VSI fed induction motor drives based on the converter DC link current feedback. It is shown that the speed and flux can be controlled over the wide speed and load range quite satisfactorily for simpler drives. The base commands of both the inverter voltage and frequency are proportional to the reference speed, but each of them is further modified by the signals derived from the DC current sensor. The algorithm is based on the equations well known from the vector control theory, and is aimed to obtain the constant rotor flux and proportionality between the electrical torque, the slip frequency and the active component of the stator current. In this way, the problems of slip compensation, Ri compensation and correction of U/f characteristics are solved in the same time. Analytical considerations and computer simulations of the proposed control structure are in close agreement with the experimental results measured on a prototype drive.

  17. Detection of DC currents and resistance measurements in longitudinal spin Seebeck effect experiments on Pt/YIG and Pt/NFO

    NASA Astrophysics Data System (ADS)

    Meier, Daniel; Kuschel, Timo; Meyer, Sibylle; Goennenwein, Sebastian T. B.; Shen, Liming; Gupta, Arunava; Schmalhorst, Jan-Michael; Reiss, Günter

    2016-05-01

    In this work we investigated thin films of the ferrimagnetic insulators Y 3Fe5O12 and NiFe2O4 capped with thin Pt layers in terms of the longitudinal spin Seebeck effect (LSSE). The electric response detected in the Pt layer under an out-of-plane temperature gradient can be interpreted as a pure spin current converted into a charge current via the inverse spin Hall effect. Typically, the transverse voltage is the quantity investigated in LSSE measurements (in the range of μV). Here, we present the directly detected DC current (in the range of nA) as an alternative quantity. Furthermore, we investigate the resistance of the Pt layer in the LSSE configuration. We found an influence of the test current on the resistance. The typical shape of the LSSE curve varies for increasing test currents.

  18. Checklist interruption and resumption: A linguistic study

    NASA Technical Reports Server (NTRS)

    Linde, Charlotte; Goguen, Joseph

    1987-01-01

    This study forms part of a project investigating the relationships among the formal structure of aviation procedures, the ways in which the crew members are taught to execute them, and the ways in which thet are actually performed in flight. Specifically, this report examines the interactions between the performance of checklists and interruptions, considering both interruptions by radio communications and by other crew members. The data consists of 14 crews' performance of a full mission simulation of a higher ratio of checklist speech acts to all speech acts within the span of the performance of the checklist. Further, it is not number of interruptions but length of interruptions which is associated with crew performance quality. Use of explicit holds is also associated with crew performance.

  19. Fast interrupt platform for extended DOS

    NASA Technical Reports Server (NTRS)

    Duryea, T. W.

    1995-01-01

    Extended DOS offers the unique combination of a simple operating system which allows direct assess to the interrupt tables, 32 bit protected mode access to a 4096 MByte address space, and the use of industry standard C compilers. The drawback is that fast interrupt handling requires both 32 bit and 16 bit versions of each real-time process interrupt handler to avoid mode switches on the interrupts. A set of tools has been developed which automates the process of transforming the output of a standard 32 bit C compiler to 16 bit interrupt code which directly handles the real mode interrupts. The entire process compiles one set of source code via a make file, which boosts productivity by making the management of the compile-link cycle very simple. The software components are in the form of classes written mostly in C. A foreground process written as a conventional application which can use the standard C libraries can communicate with the background real-time classes via a message passing mechanism. The platform thus enables the integration of high performance real-time processing into a conventional application framework.

  20. Fast interrupt platform for extended DOS

    NASA Technical Reports Server (NTRS)

    Duryea, T. W.

    1995-01-01

    Extended DOS offers the unique combination of a simple operating system which allows direct access to the interrupt tables, 32 bit protected mode access to 4096 MByte address space, and the use of industry standard C compilers. The drawback is that fast interrupt handling requires both 32 bit and 16 bit versions of each real-time process interrupt handler to avoid mode switches on the interrupts. A set of tools has been developed which automates the process of transforming the output of a standard 32 bit C compiler to 16 bit interrupt code which directly handles the real mode interrupts. The entire process compiles one set of source code via a make file, which boosts productivity by making the management of the compile-link cycle very simple. The software components are in the form of classes written mostly in C. A foreground process written as a conventional application which can use the standard C libraries can communicate with the background real-time classes via a message passing mechanism. The platform thus enables the integration of high performance real-time processing into a conventional application framework.

  1. DC current induced metal-insulator transition in epitaxial Sm{sub 0.6}Nd{sub 0.4}NiO{sub 3}/LaAlO{sub 3} thin film

    SciTech Connect

    Huang, Haoliang; Luo, Zhenlin Yang, Yuanjun; Yang, Mengmeng; Wang, Haibo; Hu, Sixia; Bao, Jun; Yun, Yu; Meng, Dechao; Lu, Yalin; Gao, Chen

    2014-05-15

    The metal-insulator transition (MIT) in strong correlated electron materials can be induced by external perturbation in forms of thermal, electrical, optical, or magnetic fields. We report on the DC current induced MIT in epitaxial Sm{sub 0.6}Nd{sub 0.4}NiO{sub 3} (SNNO) thin film deposited by pulsed laser deposition on (001)-LaAlO{sub 3} substrate. It was found that the MIT in SNNO film not only can be triggered by thermal, but also can be induced by DC current. The T{sub MI} of SNNO film decreases from 282 K to 200 K with the DC current density increasing from 0.003 × 10{sup 9} A•m{sup −2} to 4.9 × 10{sup 9} A•m{sup −2}. Based on the resistivity curves measured at different temperatures, the MIT phase diagram has been successfully constructed.

  2. Interruption as a test of the user-computer interface

    NASA Technical Reports Server (NTRS)

    Kreifeldt, J. G.; Mccarthy, M. E.

    1981-01-01

    In order to study the effects different logic systems might have on interrupted operation, an algebraic calculator and a reverse polish notation calculator were compared when trained users were interrupted during problem entry. The RPN calculator showed markedly superior resistance to interruption effects compared to the AN calculator although no significant differences were found when the users were not interrupted. Causes and possible remedies for interruption effects are speculated. It is proposed that because interruption is such a common occurrence, it be incorporated into comparative evaluation tests of different logic system and control/display system and that interruption resistance be adopted as a specific design criteria for such design.

  3. IRF6 Sequencing in Interrupted Clefting.

    PubMed

    Cuddapah, Sanmati R; Kominek, Selma; Grant, John H; Robin, Nathaniel H

    2016-05-01

    In a retrospective review of patients seen at the University of Alabama at Birmingham Cleft and Craniofacial Center, four patients with rare interrupted clefting were identified who had undergone genetic testing. Each of these patients had a typical cleft lip, with intact hard palate and cleft of the soft palate. Given this picture of mixed clefting, IRF6 sequencing was done and was negative for mutations in all four patients. As genetic testing for single-gene mutations and exome sequencing become clinically available, it may be possible to identify novel mutations responsible for this previously unreported type of interrupted clefting. PMID:26090788

  4. Development of an in situ calibration method for current-to-voltage converters for high-accuracy SI-traceable low dc current measurements

    NASA Astrophysics Data System (ADS)

    Eppeldauer, George P.; Yoon, Howard W.; Jarrett, Dean G.; Larason, Thomas C.

    2013-10-01

    For photocurrent measurements with low uncertainties, wide dynamic range reference current-to-voltage converters and a new converter calibration method have been developed at the National Institute of Standards and Technology (NIST). The high-feedback resistors of a reference converter were in situ calibrated on a high-resistivity, printed circuit board placed in an electrically shielded box electrically isolated from the operational amplifier using jumpers. The feedback resistors, prior to their installation, were characterized, selected and heat treated. The circuit board was cleaned with solvents, and the in situ resistors were calibrated using measurement systems for 10 kΩ to 10 GΩ standard resistors. We demonstrate that dc currents from 1 nA to 100 µA can be measured with uncertainties of 55 × 10-6 (k = 2) or lower, which are lower in uncertainties than any commercial device by factors of 10 to 30 at the same current setting. The internal (NIST) validations of the reference converter are described.

  5. Isolated sleep paralysis elicited by sleep interruption.

    PubMed

    Takeuchi, T; Miyasita, A; Sasaki, Y; Inugami, M; Fukuda, K

    1992-06-01

    We elicited isolated sleep paralysis (ISP) from normal subjects by a nocturnal sleep interruption schedule. On four experimental nights, 16 subjects had their sleep interrupted for 60 minutes by forced awakening at the time when 40 minutes of nonrapid eye movement (NREM) sleep had elapsed from the termination of rapid eye movement (REM) sleep in the first or third sleep cycle. This schedule produced a sleep onset REM period (SOREMP) after the interruption at a high rate of 71.9%. We succeeded in eliciting six episodes of ISP in the sleep interruptions performed (9.4%). All episodes of ISP except one occurred from SOREMP, indicating a close correlation between ISP and SOREMP. We recorded verbal reports about ISP experiences and recorded the polysomnogram (PSG) during ISP. All of the subjects with ISP experienced inability to move and were simultaneously aware of lying in the laboratory. All but one reported auditory/visual hallucinations and unpleasant emotions. PSG recordings during ISP were characterized by a REM/W stage dissociated state, i.e. abundant alpha electroencephalographs and persistence of muscle atonia shown by the tonic electromyogram. Judging from the PSG recordings, ISP differs from other dissociated states such as lucid dreaming, nocturnal panic attacks and REM sleep behavior disorders. We compare some of the sleep variables between ISP and non-ISP nights. We also discuss the similarities and differences between ISP and sleep paralysis in narcolepsy. PMID:1621022

  6. Testing Of Choiced Ceramics Cutting Tools At Irregular Interrupted Cut

    NASA Astrophysics Data System (ADS)

    Kyncl, Ladislav; Malotová, Šárka; Nováček, Pavel; Nicielnik, Henryk; Šoková, Dagmar; Hemžský, Pavel; Pitela, David; Holubjak, Jozef

    2015-12-01

    This article discusses the test of removable ceramic cutting inserts during machining irregular interrupted cut. Tests were performed on a lathe, with the preparation which simulated us the interrupted cut. By changing the number of plates mounted in a preparation it simulate us a regular or irregular interrupted cut. When with four plates it was regular interrupted cut, the remaining three variants were already irregular cut. It was examined whether it will have the irregular interrupted cutting effect on the insert and possibly how it will change life of inserts during irregular interrupted cut (variable delay between shocks).

  7. Interruptions in the wild: Development of a sociotechnical systems model of interruptions in the emergency department through a systematic review.

    PubMed

    Werner, Nicole E; Holden, Richard J

    2015-11-01

    Interruptions are unavoidable in the "interrupt driven" Emergency Department (ED). A critical review and synthesis of the literature on interruptions in the ED can offer insight into the nature of interruptions in complex real-world environments. Fifteen empirical articles on interruptions in the ED were identified through database searches. Articles were reviewed, critiqued, and synthesized. There was little agreement and several gaps in conceptualizing sociotechnical system factors, process characteristics, and interruption outcomes. While multiple outcomes of interruptions were mentioned, few were measured, and the relationship between multiple outcomes was rarely assessed. Synthesizing the literature and drawing on ergonomic concepts, we present a sociotechnical model of interruptions in complex settings that motivates new directions in research and design. The model conceptualizes interruptions as a process, not a single event, that occurs within and is shaped by an interacting socio-technical system and that results in a variety of interrelated outcomes. PMID:26154223

  8. Observation of self-magnetic field relaxations in Bi2223 and Y123 HTS tapes after over-current pulse and DC current operation

    NASA Astrophysics Data System (ADS)

    Tallouli, M.; Sun, J.; Chikumoto, N.; Otabe, E. S.; Shyshkin, O.; Charfi-Kaddour, S.; Yamaguchi, S.

    2016-07-01

    The development of power transmission lines based on long-length HTS tapes requires the production of high quality tapes. Due to fault conditions, technical mistakes and human errors during the operation of a DC power transmission line, an over-current pulse, several times larger than the rated current, could occur. To study the effect of such over-current pulses on the transport current density distribution in the HTS tapes, we simulated two start-up scenarios for one BSCCO and two YBCO tapes. The first start-up scenario is an initial over-current pulse during which the transport current was turned on rapidly, rising to 900 A during the first milliseconds, then reduced to a 100 A DC current. The second start-up scenario is normal operation, and involved increasing the transport current slowly from 0 A to 100 A at a rate of 1 A/s. For both scenarios, we then measured the vertical component of the self-magnetic field by means of a Hall probe above the tape, and afterward, by solving a linear equation of the inverse problem we obtain the current density profiles. We observe a change of the self-magnetic field above the edge of the BSCCO and YBCO tapes during 30 min after the 5 ms of over-current pulse and during the normal operation. The current density profiles are peaked in the centre for over-current pulse, and more peaked around the edge of the HTS tape for normal operation, which means that the limited time over-current pulse changes the current density profiles of the HTS tapes. We observe also a loop of current for YBCO tapes and we show the role of the HTS tape stabilizer.

  9. Energy supply interruptions and national security.

    PubMed

    Alm, A L

    1981-03-27

    Vulnerability to oil supply interruptions poses serious threats to the U.S. economy and the life-style of its citizens. The Iranian cutbacks in 1979 resulted in price increases of 120 percent in 1 year and gasoline lines across the country. Creation and use of ample public and private stocks could moderate price increases after another interruption and prevent disruption of supplies. Use of the marketplace to allocate shortages, coupled with rebates to cushion blows to the economy and hardship to individuals, would be eminently more efficient than government allocation programs. International cooperation, through coordination of stock buildup and withdrawal, could mitigate the damage from oil disruptions among all the Western nations. PMID:17731165

  10. Interrupted Binary Mass Transfer in Star Clusters

    NASA Astrophysics Data System (ADS)

    Leigh, Nathan W. C.; Geller, Aaron M.; Toonen, Silvia

    2016-02-01

    Binary mass transfer (MT) is at the forefront of some of the most exciting puzzles of modern astrophysics, including SNe Ia, gamma-ray bursts, and the formation of most observed exotic stellar populations. Typically, the evolution is assumed to proceed in isolation, even in dense stellar environments such as star clusters. In this paper, we test the validity of this assumption via the analysis of a large grid of binary evolution models simulated with the SeBa code. For every binary, we calculate analytically the mean time until another single or binary star comes within the mean separation of the mass-transferring binary, and compare this timescale to the mean time for stable MT to occur. We then derive the probability for each respective binary to experience a direct dynamical interruption. The resulting probability distribution can be integrated to give an estimate for the fraction of binaries undergoing MT that are expected to be disrupted as a function of the host cluster properties. We find that for lower-mass clusters (≲ {10}4 {M}⊙ ), on the order of a few to a few tens of percent of binaries undergoing MT are expected to be interrupted by an interloping single, or more often binary, star, over the course of the cluster lifetime, whereas in more massive globular clusters we expect \\ll 1% to be interrupted. Furthermore, using numerical scattering experiments performed with the FEWBODY code, we show that the probability of interruption increases if perturbative fly-bys are considered as well, by a factor ˜2.

  11. Atrial Fibrillation Ablation without Interruption of Anticoagulation.

    PubMed

    Santangeli, Pasquale; Di Biase, Luigi; Sanchez, Javier E; Horton, Rodney; Natale, Andrea

    2011-01-01

    Atrial fibrillation (AF) can be cured by pulmonary vein antrum isolation (PVAI) in a substantial proportion of patients. The high efficacy of PVAI is partially undermined by a small but concrete periprocedural risk of complications, such as thromboembolic events and bleeding. A correct management of anticoagulation is essential to prevent such complications. Performing PVAI without interruption of oral anticoagulation has been demonstrated feasible by our group in previous studies. Recently, we reported that continuation of therapeutic warfarin during radiofrequency catheter ablation consistently reduces the risk of periprocedural stroke/transient ischemic attack without increasing the risk of hemorrhagic events. Of note, interrupting warfarin anticoagulation may actually increase the risk of stroke even when bridged with heparin. The latter strategy is also associated with an increased risk of minor bleeding. With regard to major bleeding, we found no significant difference between patients with a therapeutic INR and those who were bridged with heparin. Therefore, continuation of therapeutic warfarin during ablation of AF appears to be the best anticoagulation strategy. In this paper we summarize our experience with AF ablation without interruption of anticoagulation. PMID:21577267

  12. 14 CFR 121.705 - Mechanical interruption summary report.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Mechanical interruption summary report. 121... interruption summary report. Each certificate holder shall submit to the Administrator, before the end of the 10th day of the following month, a summary report for the previous month of: (a) Each interruption to...

  13. 14 CFR 121.705 - Mechanical interruption summary report.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Mechanical interruption summary report. 121... interruption summary report. Each certificate holder shall submit to the Administrator, before the end of the 10th day of the following month, a summary report for the previous month of: (a) Each interruption to...

  14. 14 CFR 121.705 - Mechanical interruption summary report.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Mechanical interruption summary report. 121... interruption summary report. Each certificate holder shall submit to the Administrator, before the end of the 10th day of the following month, a summary report for the previous month of: (a) Each interruption to...

  15. Assessing Individual-Level Impact of Interruptions during Online Testing

    ERIC Educational Resources Information Center

    Sinharay, Sandip; Wan, Ping; Choi, Seung W.; Kim, Dong-In

    2015-01-01

    With an increase in the number of online tests, the number of interruptions during testing due to unexpected technical issues seems to be on the rise. For example, interruptions occurred during several recent state tests. When interruptions occur, it is important to determine the extent of their impact on the examinees' scores. Researchers such as…

  16. Determining the Overall Impact of Interruptions during Online Testing

    ERIC Educational Resources Information Center

    Sinharay, Sandip; Wan, Ping; Whitaker, Mike; Kim, Dong-In; Zhang, Litong; Choi, Seung W.

    2014-01-01

    With an increase in the number of online tests, interruptions during testing due to unexpected technical issues seem unavoidable. For example, interruptions occurred during several recent state tests. When interruptions occur, it is important to determine the extent of their impact on the examinees' scores. There is a lack of research on this…

  17. Interruptions and Distractions in Healthcare: Review and Reappraisal

    PubMed Central

    Rivera, A. Joy; Karsh, Ben-Tzion

    2010-01-01

    Healthcare settings can be hectic, demanding, time-constrained environments. Within these environments, health care professionals (HCP) are expected to perform tasks that often require their undivided attention. However, HCPs are frequently interrupted, which can distract their attention and add to the complexity of their work. That said, not all interruptions are bad; many interruptions are essential to the patient care process and provide HCPs with necessary information. This paper systematically reviews the peer-reviewed literature on interruptions in healthcare settings to determine the state of the science and to identify gaps. It then provides a complex sociotechnical systems approach to understanding interruptions in healthcare. PMID:20378621

  18. Testing of a 50 kA, 50 kV current interrupter with I sup 2 t preheating and long recovery voltage

    SciTech Connect

    Reass, W.A.; Boenig, H.J.; Melton, J.G. )

    1989-01-01

    The Confinement Physics Research Facility (CPRF) presently being constructed at Los Alamos in a next generation Reversed Field Pinch (RFP) plasma experiment. An inductive energy transfer system, employing a 50 kA, 50 kV dc current interrupter, is being utilized for initiating the plasma current. These performance requirements (50 kA, 50 kV) had yet to be realized in a reliable switching system, development of this current interrupter system was initiated. A switch test bay with a 50 kA battery bank has been built at Los Alamos to test the interrupter in conditions which will exist in the CPRF experiment. Many switch parameters were measured to provide information on the current interrupting characteristics and reliability. Some of these diagnostics include voltage, current, pre and post I{sup 2}t contact resistance, opening speed and position, arc voltage, and stem temperature. To determine any long term changes, all shots and data channels are computer indexed, and may be easily recalled for review. Extensive testing was performed on Siemens D-10 vacuum interrupter. Test parameter space included 55 kA, 40 kV (per bottle); di/dt of 2250 A/{mu}s, I{sup 2}t of 5 {times} 10{sup 9} amp{sup 2} sec; and 20 kV-200 msec RC recovery decay. Circuit parameters effect opening reliability. Circuit data and the associated testing results will be presented along with long term trends of switch performance under normal'' conditions. 12 figs.

  19. Single screw interrupted thread positive displacement mechanism

    NASA Astrophysics Data System (ADS)

    Boblitt, Wayne W.

    1992-07-01

    A single screw positive displacement compressor mechanism employing shallow gate rotor tooth penetration of the main rotor for purposes of reducing internal leakage and consequent compressor inefficiencies is presented. The invention is provided with an interrupted main rotor thread for purposes of insuring multiple gate rotor teeth meshing with the drive portion of the main rotor thread, thereby reducing gate rotor tooth flank loads in the compressor section of the device. Provision is also made for main rotor thread baffling between the main rotor chamber section and the mechanism inlet.

  20. Hybrid high direct current circuit interrupter

    DOEpatents

    Rockot, Joseph H.; Mikesell, Harvey E.; Jha, Kamal N.

    1998-01-01

    A device and a method for interrupting very high direct currents (greater than 100,000 amperes) and simultaneously blocking high voltages (greater than 600 volts). The device utilizes a mechanical switch to carry very high currents continuously with low loss and a silicon controlled rectifier (SCR) to bypass the current around the mechanical switch while its contacts are separating. A commutation circuit, connected in parallel with the SCR, turns off the SCR by utilizing a resonant circuit to divert the SCR current after the switch opens.

  1. Hybrid high direct current circuit interrupter

    DOEpatents

    Rockot, J.H.; Mikesell, H.E.; Jha, K.N.

    1998-08-11

    A device and a method are disclosed for interrupting very high direct currents (greater than 100,000 amperes) and simultaneously blocking high voltages (greater than 600 volts). The device utilizes a mechanical switch to carry very high currents continuously with low loss and a silicon controlled rectifier (SCR) to bypass the current around the mechanical switch while its contacts are separating. A commutation circuit, connected in parallel with the SCR, turns off the SCR by utilizing a resonant circuit to divert the SCR current after the switch opens. 7 figs.

  2. Interrupt handling in a multiprocessor computing system

    SciTech Connect

    D'Amico, L.W.; Guyer, J.M.

    1989-01-03

    A multiprocessor computing system is described comprising: a system bus, including an address bus for carrying an address phase of an instruction and a data bus for carrying a data phase of an instruction; a plurality of processing units connected to the system bus, each processing unit including means for generating broadcast interrupt origin request instructions on the system bus; asynchronous input/output channel controllers connected to the system bus, each of the input/output channel controllers including means for generating a synchronizing signal in response to completion of an address phase of a broadcast instruction on the system bus, and corresponding to a different one of the processing units connected through each of the input/output channel controllers, the input/output channel controllers being arranged on the priority lines in order of priority, the priority lines being gated in an input/output channel controller so that priority is asserted over all lower priority input/output channel controllers on a priority line by an input/output channel controller if the input/output channel controller has an interrupt pending in the input/output channel controller for the processing unit corresponding to the priority line.

  3. Nanosecond photolytic interruption of bacteriorhodopsin photocycle

    PubMed Central

    Bazhenov, V.; Schmidt, P.; Atkinson, G. H.

    1992-01-01

    The molecular processes comprising the room temperature bacteriorhodopsin (BR) photocycle are examined through the properties of the photo-induced reverse reaction, K-590 + hν → BR-570 (K → BR). Two sequential pumping pulses, each of 10-ns duration, are used, respectively, to initiate the photocycle via the forward BR-570 + hν → K-590 (BR → K) reaction (532 nm) and to photolytically interrupt the thermal BR photocycle after a 20-ns delay via K → BR (620-700 nm). The ground-state BR-570 population, monitored by 633-nm absorption 200 μs after the photocycle begins, provides a quantitative measure of the efficiency with which K → BR interrupts the photocycle to reform BR-570. The quantum yield (Φ) for K → BR is found to be 1.6 ± 0.1 times larger than that for BR → K which, when compared to a Φ of 0.64 for BR → K, suggests that Φ for K → BR is ≈ 1.0. The significance of such a high efficiency K → BR reaction with respect to mechanistic descriptions of the BR photocycle is discussed. PMID:19431837

  4. Interrupting the Interruption: Neoliberalism and the Challenges of an Antiracist School

    ERIC Educational Resources Information Center

    Meshulam, Assaf; Apple, Michael W.

    2014-01-01

    The article examines a US public elementary bilingual, multicultural school that attempts to interrupt the reproduction of existing relations of dominance and subordination across a variety of differences. The school's experiences illuminate the complex reality of schools as a site of struggle and compromise between at times contradictory…

  5. Pulsed interrupter and method of operation

    SciTech Connect

    Drake, Joel Lawton; Kratz, Robert

    2015-06-09

    Some embodiments provide interrupter systems comprising: a first electrode; a second electrode; a piston movably located at a first position and electrically coupled with the first and second electrodes establishing a closed state, the piston comprises an electrical conductor that couples with the first and second electrodes providing a conductive path; an electromagnetic launcher configured to, when activated, induce a magnetic field pulse causing the piston to move away from the electrical coupling with the first and second electrodes establishing an open circuit between the first and second electrodes; and a piston control system comprising a piston arresting system configured to control a deceleration of the piston following the movement of the piston induced by the electromagnetic launcher such that the piston is not in electrical contact with at least one of the first electrode and the second electrode when in the open state.

  6. Interrupting Intergenerational Cycles of Maternal Obesity.

    PubMed

    Gillman, Matthew W

    2016-01-01

    Factors operating in the preconception and prenatal periods, such as maternal obesity, excessive gestational weight gain and gestational diabetes, predict a substantial fraction of childhood obesity as well as lifelong adverse health consequences in the mother. These periods may lend themselves to successful intervention to reduce such risk factors because parents may be especially willing to change behavior if it confers health advantages to their children. If effective interventions started before or during pregnancy can be maintained after birth, they have the potential to lower the risk of both maternal obesity in the next pregnancy and obesity in the growing child, thus helping to interrupt maternal and child intergenerational vicious cycles of obesity, diabetes and related cardiometabolic health consequences. While this paradigm is appealing, challenges include determining the magnitude, causality and modifiability of these risk factors, and quantifying any adverse consequences of intervention. PMID:27088333

  7. Operational Failures and Interruptions in Hospital Nursing

    PubMed Central

    Tucker, Anita L; Spear, Steven J

    2006-01-01

    Objective To describe the work environment of hospital nurses with particular focus on the performance of work systems supplying information, materials, and equipment for patient care. Data Sources Primary observation, semistructured interviews, and surveys of hospital nurses. Study Design We sampled a cross-sectional group of six U.S. hospitals to examine the frequency of work system failures and their impact on nurse productivity. Data Collection We collected minute-by-minute data on the activities of 11 nurses. In addition, we conducted interviews with six of these nurses using questions related to obstacles to care. Finally, we created and administered two surveys in 48 nursing units, one for nurses and one for managers, asking about the frequency of specific work system failures. Principal Findings Nurses we observed experienced an average of 8.4 work system failures per 8-hour shift. The five most frequent types of failures, accounting for 6.4 of these obstacles, involved medications, orders, supplies, staffing, and equipment. Survey questions asking nurses how frequently they experienced these five categories of obstacles yielded similar frequencies. For an average 8-hour shift, the average task time was only 3.1 minutes, and in spite of this, nurses were interrupted mid-task an average of eight times per shift. Conclusions Our findings suggest that nurse effectiveness can be increased by creating improvement processes triggered by the occurrence of work system failures, with the goal of reducing future occurrences. Second, given that nursing work is fragmented and unpredictable, designing processes that are robust to interruption can help prevent errors. PMID:16704505

  8. 30 CFR 18.48 - Circuit-interrupting devices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Circuit-interrupting devices. 18.48 Section 18..., AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.48 Circuit-interrupting devices. (a) Each machine shall be equipped with...

  9. 30 CFR 18.48 - Circuit-interrupting devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Circuit-interrupting devices. 18.48 Section 18..., AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.48 Circuit-interrupting devices. (a) Each machine shall be equipped with...

  10. 30 CFR 18.48 - Circuit-interrupting devices.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Circuit-interrupting devices. 18.48 Section 18..., AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.48 Circuit-interrupting devices. (a) Each machine shall be equipped with...

  11. 30 CFR 18.48 - Circuit-interrupting devices.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 1 2013-07-01 2013-07-01 false Circuit-interrupting devices. 18.48 Section 18..., AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.48 Circuit-interrupting devices. (a) Each machine shall be equipped with...

  12. 30 CFR 18.48 - Circuit-interrupting devices.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Circuit-interrupting devices. 18.48 Section 18..., AND APPROVAL OF MINING PRODUCTS ELECTRIC MOTOR-DRIVEN MINE EQUIPMENT AND ACCESSORIES Construction and Design Requirements § 18.48 Circuit-interrupting devices. (a) Each machine shall be equipped with...

  13. 14 CFR 135.417 - Mechanical interruption summary report.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Mechanical interruption summary report. 135... Maintenance, Preventive Maintenance, and Alterations § 135.417 Mechanical interruption summary report. Each certificate holder shall mail or deliver, before the end of the 10th day of the following month, a...

  14. 14 CFR 91.1417 - CAMP: Mechanical interruption summary report.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Ownership Operations Program Management § 91.1417 CAMP: Mechanical interruption summary report. Each program... of the following month, a summary report of the following occurrences in multiengine aircraft for the... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false CAMP: Mechanical interruption...

  15. 14 CFR 91.1417 - CAMP: Mechanical interruption summary report.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Ownership Operations Program Management § 91.1417 CAMP: Mechanical interruption summary report. Each program... of the following month, a summary report of the following occurrences in multiengine aircraft for the... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false CAMP: Mechanical interruption...

  16. 14 CFR 135.417 - Mechanical interruption summary report.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Mechanical interruption summary report. 135... Maintenance, Preventive Maintenance, and Alterations § 135.417 Mechanical interruption summary report. Each certificate holder shall mail or deliver, before the end of the 10th day of the following month, a...

  17. 43 CFR 3481.4 - Temporary interruption in coal severance.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Temporary interruption in coal severance... LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) COAL EXPLORATION AND MINING OPERATIONS RULES General Provisions § 3481.4 Temporary interruption in coal severance....

  18. 43 CFR 3481.4 - Temporary interruption in coal severance.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Temporary interruption in coal severance... LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) COAL EXPLORATION AND MINING OPERATIONS RULES General Provisions § 3481.4 Temporary interruption in coal severance....

  19. 43 CFR 3481.4 - Temporary interruption in coal severance.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Temporary interruption in coal severance... LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) COAL EXPLORATION AND MINING OPERATIONS RULES General Provisions § 3481.4 Temporary interruption in coal severance....

  20. 43 CFR 3481.4 - Temporary interruption in coal severance.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Temporary interruption in coal severance... LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) COAL EXPLORATION AND MINING OPERATIONS RULES General Provisions § 3481.4 Temporary interruption in coal severance....

  1. 34 CFR 650.35 - May fellowship tenure be interrupted?

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false May fellowship tenure be interrupted? 650.35 Section... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM What Conditions Must be Met By Fellows? § 650.35 May fellowship tenure be interrupted? (a) An institution of higher education...

  2. 34 CFR 650.35 - May fellowship tenure be interrupted?

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false May fellowship tenure be interrupted? 650.35 Section... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM What Conditions Must be Met By Fellows? § 650.35 May fellowship tenure be interrupted? (a) An institution of higher education...

  3. 34 CFR 650.35 - May fellowship tenure be interrupted?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false May fellowship tenure be interrupted? 650.35 Section... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM What Conditions Must be Met By Fellows? § 650.35 May fellowship tenure be interrupted? (a) An institution of higher education...

  4. 34 CFR 650.35 - May fellowship tenure be interrupted?

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false May fellowship tenure be interrupted? 650.35 Section... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM What Conditions Must be Met By Fellows? § 650.35 May fellowship tenure be interrupted? (a) An institution of higher education...

  5. 34 CFR 650.35 - May fellowship tenure be interrupted?

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false May fellowship tenure be interrupted? 650.35 Section... POSTSECONDARY EDUCATION, DEPARTMENT OF EDUCATION JACOB K. JAVITS FELLOWSHIP PROGRAM What Conditions Must be Met By Fellows? § 650.35 May fellowship tenure be interrupted? (a) An institution of higher education...

  6. 14 CFR 135.417 - Mechanical interruption summary report.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Mechanical interruption summary report. 135... Maintenance, Preventive Maintenance, and Alterations § 135.417 Mechanical interruption summary report. Each... report of the following occurrences in multiengine aircraft for the preceding month to the...

  7. Career Interruptions and Subsequent Earnings: A Reexamination Using Swedish Data.

    ERIC Educational Resources Information Center

    Albrecht, James W.; Edin, Per-Anders; Sundstrom, Marianne; Vroman, Susan B.

    1999-01-01

    Cross-sectional and panel estimations of Swedish data reveal that different types of career interruptions have different effects on wages, varying by gender. Therefore, human capital depreciation does not entirely account for the negative effect of career interruptions on subsequent wages. (SK)

  8. We Interrupt This Program...Attention for Television Sequences.

    ERIC Educational Resources Information Center

    Geiger, Seth; Reeves, Byron

    A study assessed the variable amounts of attention that are required for a viewer to process two kinds of interruptions that commonly occur in television: the shift from one message to a different, unexpected message; and the reference to previously presented material that follows an interruption. Twenty-six subjects recruited from an…

  9. The Effect of Interruptions on Part 121 Air Carrier Operations

    NASA Technical Reports Server (NTRS)

    Damos, Diane L.

    1998-01-01

    The primary purpose of this study was to determine the relative priorities of various events and activities by examining the probability that a given activity was interrupted by a given event. The analysis will begin by providing frequency of interruption data by crew position (captain versus first officer) and event type. Any differences in the pattern of interruptions between the first officers and the captains will be explored and interpreted in terms of standard operating procedures. Subsequent data analyses will focus on comparing the frequency of interruptions for different types of activities and for the same activities under normal versus emergency conditions. Briefings and checklists will receive particular attention. The frequency with which specific activities are interrupted under multiple- versus single-task conditions also will be examined; because the majority of multiple-task data were obtained under laboratory conditions, LOFT-type tapes offer a unique opportunity to examine concurrent task performance under 'real-world' conditions. A second purpose of this study is to examine the effects of the interruptions on performance. More specifically, when possible, the time to resume specific activities will be compared to determine if pilots are slower to resume certain types of activities. Errors in resumption or failures to resume specific activities will be noted and any patterns in these errors will be identified. Again, particular attention will be given to the effects of interruptions on the completion of checklists and briefings. Other types of errors and missed events (i.e., the crew should have responded to the event but did not) will be examined. Any methodology using interruptions to examine task prioritization must be able to identify when an interruption has occurred and describe the ongoing activities that were interrupted. Both of these methodological problems are discussed In detail in the following section,

  10. Servicing a globally broadcast interrupt signal in a multi-threaded computer

    DOEpatents

    Attinella, John E.; Davis, Kristan D.; Musselman, Roy G.; Satterfield, David L.

    2015-12-29

    Methods, apparatuses, and computer program products for servicing a globally broadcast interrupt signal in a multi-threaded computer comprising a plurality of processor threads. Embodiments include an interrupt controller indicating in a plurality of local interrupt status locations that a globally broadcast interrupt signal has been received by the interrupt controller. Embodiments also include a thread determining that a local interrupt status location corresponding to the thread indicates that the globally broadcast interrupt signal has been received by the interrupt controller. Embodiments also include the thread processing one or more entries in a global interrupt status bit queue based on whether global interrupt status bits associated with the globally broadcast interrupt signal are locked. Each entry in the global interrupt status bit queue corresponds to a queued global interrupt.

  11. Undulator interruption in high-gain free electron lasers

    SciTech Connect

    Kim, K.J.

    1997-10-01

    The effect of interrupting an undulator on the performance of high-gain free-electron lasers (FELs) is evaluated by analyzing 1-D Maxwell-Vlasov equations. It is found that the effect is small for a reasonable length of the interruptions for FEL parameters envisaged for short wavelength self-amplified spontaneous emission (SASE). Since the interruptions provide valuable space for quadrupoles and diagnostics, and at the same time permit a greater flexibility in mechanical design, the result of this paper is encouraging for construction of long undulator magnets required for SASE.

  12. Interruption costs, customer satisfaction and expectations for service reliability

    SciTech Connect

    Sullivan, M.J.; Suddeth, B.N.; Vardell, T.; Vojdani, A.

    1996-05-01

    This paper summarizes results of a comprehensive study of the economic value of electric service carried out by Duke Power Company in cooperation with the Electric Power Research Institute. In the study, customer interruption costs were estimated for generation, transmission and distribution outages of differencing lengths occurring under varying circumstances. Interruption costs for momentary outages and voltage disturbances are also reported. In addition to these economic indicators of customer value of service, customer expectations for service reliability and power quality and their satisfaction with the service currently offered are reported. Statistical methods and procedures used in estimating interruption costs are described.

  13. Railgun power supply system utilizing traction motors and vacuum interrupters

    SciTech Connect

    Parsons, W.M.; Parker, J.V.; Thullen, P.

    1985-01-01

    A railgun power supply has been designed that utilizes traction motors, vacuum interrupters and pulse transformers. An assembly of 28 traction motors, which store approximately 75 MJ, energize the primary windings of three pulse transformers at a peak current of 50 kA. At peak current an array of vacuum interrupters disconnects the transformer primary windings and forces the current to flow in the secondary windings. The secondary windings are connected directly to the railgun and require no opening switches. By staging the vacuum interrupter openings, a 1 MA to 1.3 MA ramped current waveform can be delivered to the railgun.

  14. Deformation of contact surfaces in a vacuum interrupter after high-current interruptions

    NASA Astrophysics Data System (ADS)

    Wang, Haoran; Wang, Zhenxing; Zhou, Zhipeng; Jiang, Yanjun; Wang, Jianhua; Geng, Yingsan; Liu, Zhiyuan

    2016-08-01

    In a high-current interruption, the contact surface in a vacuum interrupter might be severely damaged by constricted vacuum arcs causing a molten area on it. As a result, a protrusion will be initiated by a transient recovery voltage after current zero, enhancing the local electric field and making breakdowns occur easier. The objective of this paper is to simulate the deformation process on the molten area under a high electric field by adopting the finite element method. A time-dependent Electrohydrodynamic model was established, and the liquid-gas interface was tracked by the level-set method. From the results, the liquid metal can be deformed to a Taylor cone if the applied electric field is above a critical value. This value is correlated to the initial geometry of the liquid metal, which increases as the size of the liquid metal decreases. Moreover, the buildup time of a Taylor cone obeys the power law t = k × E-3, where E is the initial electric field and k is a coefficient related to the material property, indicating a temporal self-similar characteristic. In addition, the influence of temperature has little impact on the deformation but has great impact on electron emission. Finally, the possible reason to initiate a delayed breakdown is associated with the deformation. The breakdown does not occur immediately when the voltage is just applied upon the gap but is postponed to several milliseconds later when the tip is formed on the liquid metal.

  15. Denitrogenation interruptions with air. [resulting in decompression sickness

    NASA Technical Reports Server (NTRS)

    Cooke, J. P.

    1976-01-01

    A 3-h denitrogenation period at ground-level pressure with 95% O2-5% N2, with an air interruption of 5 min or more and matched with additional denitrogenation time equal to the interruption, will later result occasionally in altitude decompression sickness ('bends') during a 2-h decompression exposure at 3.8 psia (10,058 m equivalent) with 92% O2- 8% N2. Thus the equal time or 'mirror-image' make-up time for loss of denitrogenation did not prevent bends 7 times in 17 subjects during 71 exposures with air interruptions; on the other hand, no case of bends was reported after uninterrupted denitrogenation periods. Nitrogen-loading during the interruptive period is believed to resupply the bends sites with additional nitrogen, which re-establishes conditions favoring a return to a high incidence of bends.

  16. Resistance Welder Using 480-Vac Ground-Fault Interrupter

    NASA Technical Reports Server (NTRS)

    Huston, Steven W.; Kroy, Ralph E.; Macfarlane, Douglas I.

    1989-01-01

    Use of ground-fault interrupters in 480-Vac power supplies of portable resistance welding machines proposed. Enhances safety and quality of welds by detecting damage in long power cable to portable resistance welder.

  17. Strategies for preventing distractions and interruptions in the OR.

    PubMed

    Clark, Gregory J

    2013-06-01

    Stakeholders in the automotive industry, airline industry, and anesthesia profession have identified critical periods of time in which distractions and interruptions of normal processes can have devastating effects. Just as reducing distractions improves safety in an automobile or airplane cockpit, limiting distractions and interruptions during critical times in the perioperative setting can increase patient safety. We assessed perioperative nurses and identified what they perceived as critical phases of nursing care. We also worked with our anesthesia partners to address their concerns about interruptions during the administration of nerve blocks. The perioperative nurses at our hospital initiated strategies to reduce distractions or interruptions to their practice at critical points, and, in collaboration with surgical committee members, we developed strategies to reduce or eliminate distractions for anesthesia professionals during the preoperative administration of nerve blocks and to eliminate distractions for the RN circulator and scrub person during the final counts. PMID:23722034

  18. A case of neonatal arterial thrombosis mimicking interrupted aortic arch

    PubMed Central

    Gürsu, Hazım Alper; Varan, Birgül; Oktay, Ayla; Özkan, Murat

    2015-01-01

    Neonatal arterial thrombosis is a very rare entity with clinical findings resembling coarctation of aorta or interrupted aortic arch. A two day-old male newborn was admitted to a different hospital with difficulty in sucking and sleepiness. On echocardiographic examination, a diagnosis of interrupted aortic arch was made and he was treated with prostoglandin E2. When the patient presented to our center, physical examination revealed that his feet were bilaterally cold. The pulses were not palpable and there were ecchymotic regions in the lower extremities. Echocardiography ruled out interrupted aortic arch. Computerized tomographic angiography revealed a large thrombosis and total occlusion of the abdominal aorta. Since there was no response to treatment with tissue plasminogen activator, we performed thrombectomy. Homozygous Factor V Leiden and Methylenetetrahydrofolate reductase mutations were found in this patient. Neonatal aortic thrombosis which is observed very rarely and fatal should be considered in the differential diagnosis of coarctation of aorta and interrupted aortic arch. PMID:26265897

  19. 15. INTERRUPTED SILL, SEATED AND MORTICED INTO HOLESET POST (NOTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. INTERRUPTED SILL, SEATED AND MORTICED INTO HOLE-SET POST (NOTE LOWER END CUT OFF AND SHOVED UP WITH BRICK UNDERPINNING) - Cedar Park, Cumberstone Road on West River, Cumberstone, Anne Arundel County, MD

  20. Proximal Interruption of the Pulmonary Artery: A Case Series

    PubMed Central

    Anand, S.H.; Mani, Sunithi Elizabeth; Joseph, Elizabeth; Mathai, John

    2015-01-01

    We present a few cases of Proximal Interruption of the Pulmonary Artery, an uncommon developmental anomaly associated with congenital heart disease. The cases had varied clinical presentations. Chest radiograph showed a hypoplastic lung with an ipsilateral small hilum on the side of the interruption and hyperinflation of the contralateral lung. Contrast CT confirmed the diagnosis, demonstrating non-visualization of the left or right pulmonary artery, and other related findings. PMID:26816968

  1. Proximal Interruption of the Pulmonary Artery: A Case Series.

    PubMed

    Anand, S H; Jasper, Anitha; Mani, Sunithi Elizabeth; Joseph, Elizabeth; Mathai, John

    2015-12-01

    We present a few cases of Proximal Interruption of the Pulmonary Artery, an uncommon developmental anomaly associated with congenital heart disease. The cases had varied clinical presentations. Chest radiograph showed a hypoplastic lung with an ipsilateral small hilum on the side of the interruption and hyperinflation of the contralateral lung. Contrast CT confirmed the diagnosis, demonstrating non-visualization of the left or right pulmonary artery, and other related findings. PMID:26816968

  2. Suicide risk characteristics among aborted, interrupted, and actual suicide attempters.

    PubMed

    Burke, Taylor A; Hamilton, Jessica L; Ammerman, Brooke A; Stange, Jonathan P; Alloy, Lauren B

    2016-08-30

    Few studies have investigated suicide risk characteristics associated with interrupted and aborted suicide attempts. The present study aimed to empirically examine whether assessing a history of interrupted and aborted suicide attempts is valuable when assessing suicide risk, given the relative lack of literature in this area to date. To inform this question, the current study examined differences in risk factors for suicidal behavior among individuals who have carried out a suicide attempt, individuals who report having a history of only interrupted and/or aborted suicide attempts, and non-attempter controls. Approximately 447 undergraduates (M=21.10 years; SD=4.16; 77.6% female) completed measures of carried out suicide attempts, interrupted suicide attempts, aborted suicide attempts, acquired capability for suicide, suicide likelihood, depressive symptoms, suicidal ideation, and non-suicidal self-injury. Results suggest that a faction of individuals endorse interrupted and/or aborted suicide attempts (8.7%), but do not endorse carried out suicide attempts, even in non-clinical samples. Furthermore, results suggest that there are few clinically meaningful differences between those with a history of carried out suicide attempts and interrupted/aborted suicide attempts, suggesting that individuals with a history of these lesser studied suicidal behaviors are an important group to target for suicide risk intervention. PMID:27344029

  3. The Effect of Interruption Duration and Demand on Resuming Suspended Goals

    ERIC Educational Resources Information Center

    Monk, Christopher A.; Trafton, J. Gregory; Boehm-Davis, Deborah A.

    2008-01-01

    The time to resume task goals after an interruption varied depending on the duration and cognitive demand of interruptions, as predicted by the memory for goals model (Altmann & Trafton, 2002). Three experiments using an interleaved tasks interruption paradigm showed that longer and more demanding interruptions led to longer resumption times in a…

  4. The Nature of Procedural Interrupts in Ground Operations in Aerospace Systems

    NASA Technical Reports Server (NTRS)

    Irwin, Cheryl M.; Kanki, Barbara G.; Shafto, Michael G. (Technical Monitor)

    1995-01-01

    This study proposes a methodology for characterizing the causal context and consequences of procedural interrupts in ground operations tasks. Behavioral science researchers observed 26 tasks at NASA's Kennedy Space Center. From these tasks, 81 procedural interrupts were identified and coded for the following information: source of the interrupt, circumstances surrounding the interrupt, and consequences of the interrupt. We found that more interrupts were equipment or personnel-related than procedure-related. More interrupts were due to unavailable resources or resources being incorrect than resources being inaccessible, and most interrupts resulted in some action being taken. Variation in duration of procedural interrupts across causal categories was also examined. The characterization process helps to identify those interrupts that are disruptive, those that cannot be avoided, and those that may have been prevented through better planning or scheduling of resources. Implications for the use of the methodology and suggestions for further research are discussed.

  5. Fundamentals of interruption in vacuum. Eighth progress report

    SciTech Connect

    Greenwood, A N; Childs, S E

    1980-05-30

    In analyzing the behavior of a vacuum arc during interruption , a mathematical model has been set up to describe the events occurring in the interelectrode gap during interruption. The reliability of the results obtained using such a model depends on the accuracy of the initial assumptions made in setting up the model equations. Previous results obtained from the model analysis were compared to experimental data and it was found that there was a discrepancy close to current zero. To improve our model results some of the original model assumptions have been reconsidered in order to make the model more closely represent the physical reality of a vacuum arc.

  6. "Interruptions disrupt reading comprehension": Correction to Foroughi et al. (2015).

    PubMed

    2016-07-01

    Reports an error in "Interruptions disrupt reading comprehension" by Cyrus K. Foroughi, Nicole E. Werner, Daniela Barragán and Deborah A. Boehm-Davis (Journal of Experimental Psychology: General, 2015[Jun], Vol 144[3], 704-709). In the article the effect sizes (Cohen's d) were reported using the incorrect formula. The correct formula and effect sizes are provided. (The following abstract of the original article appeared in record 2015-15250-001.) Previous research suggests that being interrupted while reading a text does not disrupt the later recognition or recall of information from that text. This research is used as support for Ericsson and Kintsch's (1995) long-term working memory (LT-WM) theory, which posits that disruptions while reading (e.g., interruptions) do not impair subsequent text comprehension. However, to fully comprehend a text, individuals may need to do more than recognize or recall information that has been presented in the text at a later time. Reading comprehension often requires individuals to connect and synthesize information across a text (e.g., successfully identifying complex topics such as themes and tones) and not just make a familiarity-based decision (i.e., recognition). The goal for this study was to determine whether interruptions while reading disrupt reading comprehension when the questions assessing comprehension require participants to connect and synthesize information across the passage. In Experiment 1, interruptions disrupted reading comprehension. In Experiment 2, interruptions disrupted reading comprehension but not recognition of information from the text. In Experiment 3, the addition of a 15-s time-out prior to the interruption successfully removed these negative effects. These data suggest that the time it takes to process the information needed to successfully comprehend text when reading is greater than that required for recognition. Any interference (e.g., an interruption) that occurs during the comprehension

  7. Institutional Narcissism, Arrogant Organization Disorder and Interruptions in Organizational Learning

    ERIC Educational Resources Information Center

    Godkin, Lynn; Allcorn, Seth

    2009-01-01

    Purpose: This article aims to present an alternative approach to diagnosing behavioral barriers to organizational learning. Design/methodology/approach: The paper juxtaposes interruptions in organizational learning with characteristics of narcissism and arrogant organization disorder. Psychoanalytically informed theory and DSM-IV criteria are…

  8. The Needs of Others: Gender and Sleep Interruptions for Caregivers

    ERIC Educational Resources Information Center

    Burgard, Sarah A.

    2011-01-01

    Received wisdom, some sociological theory and a handful of qualitative studies suggest that the "night shift" of caregiving work that interrupts sleep is a burden borne disproportionately by women. However, there is no broadly representative evidence to substantiate claims about who takes the night shift in contemporary American households.…

  9. 14 CFR 91.1417 - CAMP: Mechanical interruption summary report.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false CAMP: Mechanical interruption summary report. 91.1417 Section 91.1417 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES GENERAL OPERATING AND FLIGHT RULES Fractional Ownership Operations Program Management...

  10. 14 CFR 135.417 - Mechanical interruption summary report.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Mechanical interruption summary report. 135.417 Section 135.417 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: COMMUTER AND ON...

  11. 14 CFR 121.705 - Mechanical interruption summary report.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Mechanical interruption summary report. 121.705 Section 121.705 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS OPERATING REQUIREMENTS: DOMESTIC, FLAG,...

  12. 38 CFR 21.5078 - Interruption to conserve entitlement.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Interruption to conserve entitlement. 21.5078 Section 21.5078 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-Vietnam Era Veterans' Educational Assistance...

  13. Toy Modification Note: Build It Yourself Battery Interrupter. Revised.

    ERIC Educational Resources Information Center

    Vanderheiden, Gregg C.; Brandenburg, S.

    This toy modification note presents illustrated instructions on how to build a battery interrupter that permits on/off control of battery-operated toys without modification of the toys themselves. The device allows for a separate control switch which can be custom designed to fit a handicapped user's needs. Information on the construction and use…

  14. 14 CFR 91.1417 - CAMP: Mechanical interruption summary report.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false CAMP: Mechanical interruption summary report. 91.1417 Section 91.1417 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... preceding month to the Flight Standards District Office that issued the management specifications: (a)...

  15. Effect of unloading time on interrupted creep in copper

    SciTech Connect

    Chandler, H.D. . School of Mechanical Engineering)

    1994-06-01

    The effect of unloading time on the interrupted creep behavior of polycrystalline copper specimens was investigated over the temperature range 298--773 K. Up to 553 K, cyclic creep acceleration could be explained in terms of deformation and hardening using a dislocation glide model with recovery during unloading being due to dislocation climb. At higher temperatures, recrystallization effects probably influence behavior.

  16. Teaching Spontaneous Communication in Natural Settings through Interrupted Behavior Chains.

    ERIC Educational Resources Information Center

    Hunt, Pam; Goetz, Lori

    1988-01-01

    The article describes the use of interrupted behavior chains to teach communication skills in natural settings with autistic students. Empirical and theoretical bases for the training strategy are explained as are specific procedures for implementing the strategy. Implications of the strategy for classroom organization and service delivery are…

  17. 42 CFR 412.618 - Assessment process for interrupted stays.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Assessment process for interrupted stays. 412.618... SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES Prospective Payment for Inpatient Rehabilitation Hospitals and Rehabilitation Units § 412.618 Assessment process...

  18. 42 CFR 412.618 - Assessment process for interrupted stays.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 2 2011-10-01 2011-10-01 false Assessment process for interrupted stays. 412.618... SERVICES MEDICARE PROGRAM PROSPECTIVE PAYMENT SYSTEMS FOR INPATIENT HOSPITAL SERVICES Prospective Payment for Inpatient Rehabilitation Hospitals and Rehabilitation Units § 412.618 Assessment process...

  19. 38 CFR 21.5078 - Interruption to conserve entitlement.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2011-07-01 2011-07-01 false Interruption to conserve entitlement. 21.5078 Section 21.5078 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-Vietnam Era Veterans' Educational Assistance...

  20. 38 CFR 21.5078 - Interruption to conserve entitlement.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2013-07-01 2013-07-01 false Interruption to conserve entitlement. 21.5078 Section 21.5078 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-Vietnam Era Veterans' Educational Assistance...

  1. 38 CFR 21.5078 - Interruption to conserve entitlement.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2012-07-01 2012-07-01 false Interruption to conserve entitlement. 21.5078 Section 21.5078 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-Vietnam Era Veterans' Educational Assistance...

  2. 38 CFR 21.5078 - Interruption to conserve entitlement.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2014-07-01 2014-07-01 false Interruption to conserve entitlement. 21.5078 Section 21.5078 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) VOCATIONAL REHABILITATION AND EDUCATION Post-Vietnam Era Veterans' Educational Assistance...

  3. The long-term costs of career interruptions.

    PubMed

    Ketsche, Patricia G; Branscomb, Lisette

    2003-01-01

    This article is based on a study that analyzed the long-term salary implications of career choices made by healthcare administrators. The study used a cohort of graduates from a single health administration program; these individuals had comparable levels of human capital at the outset of their careers. We estimated the effect of periods of part-time employment and job interruptions--voluntary and involuntary--on long-term salary progression. We also estimated the impact of other career choices, such as membership in a professional organization or the decision to relocate. After controlling for these choices, we estimated the residual effect of gender on salary. We found that voluntary interruptions had a greater effect on long-term salary growth than did involuntary interruptions of the same length or periods of part-time employment. Individuals evaluating options for balancing career and family constraints should understand the long-term cost of choosing a career interruption rather than part-time employment during periods of heightened responsibilities outside the workplace. Healthcare administrators should also be educated about the positive association between professional memberships and career advancement to make informed decisions about participation in such organizations. Surprisingly, after controlling for all choice variables, gender had no measurable effect on long-term salary growth. Half of those who indicated a voluntary interruption for dependent care reasons preferred part-time or flexible-hour work if it had been available. These results suggest that a pool of healthcare administrators might compete for positions if more part-time opportunities were available. PMID:12592867

  4. Ascending Aortic Slide for Interrupted Aortic Arch Repair.

    PubMed

    Urencio, Miguel; Dodge-Khatami, Ali; Greenleaf, Chris E; Aru, Giorgio; Salazar, Jorge D

    2016-09-01

    For repair of interrupted aortic arch, unfavorable anatomy challenges a tension-free anastomosis. We describe a useful alternative surgical technique used in five neonates/infants, involving splitting the ascending aorta from the sinotubular junction to the arch origin, leftward and posterior "sliding" of the flap with anastomosis to the distal arch creating a native tissue bridge, and reconstruction with a patch. With wide interruption gaps between proximal and distal aortic portions, the ascending aortic slide is a safe and reproducible technique, providing a tension-free native tissue bridge with potential for growth, and a scaffold for patch augmentation in biventricular hearts, or for Norwood stage I in univentricular palliation. PMID:27587504

  5. Reversible harmless interruption of testicular blood supply in the ram

    SciTech Connect

    van Vliet, J.; De Ruiter-Bootsma, A.L.; Oei, Y.H.; Hoekstra, A.; De Rooij, D.G.; Wensing, C.J.

    1987-03-01

    An effective method of interrupting testicular blood flow temporarily and repeatedly in the ram has been developed. Blockade of flow has been achieved mechanically by an inflatable occluder placed around the testicular artery at the level of the spermatic cord. The effect of the blockade on total testicular blood supply was investigated using Doppler flowmetry and a percutaneous Xenon-133 injection method. With both approaches, the blood flow changes after inflation or deflation of the occluders could be estimated satisfactorily. A substantial decrease of testicular blood flow was achieved in eight of the 10 testes with inflated occluders. However, there were indications that in the remaining two testes blockade of the arterial flow was not complete. After deflation of the occluders, blood flow was restored rapidly and completely in all testes. Macro- and microscopic examinations revealed no long-term damage to the testis after blood flow interruptions lasting 30 or 60 minutes.

  6. Modification of seizure disorders: the interruption of behavioral chains.

    PubMed Central

    Zlutnick, S; Mayville, W J; Moffat, S

    1975-01-01

    This study investigated the effects of interruption and differential reinforcement on seizures in children. Seizures were conceptualized as the terminal link in a behavioral chain, resulting in a strategy aimed at identifying and modifying behaviors that reliably preceded the seizure climax. Seizure frequency was reduced in four of five subjects, whereas the frequency of preseizure behavior was reduced in only three subjects. Parents and school personnel were successfully used as change agents. PMID:1141076

  7. Interrupted searches in the BBMCSFilter context for MINLP problems

    NASA Astrophysics Data System (ADS)

    Fernandes, Florbela P.; Costa, M. Fernanda P.; Fernandes, Edite M. G. P.

    2016-06-01

    The BBMCSFilter method was developed to solve mixed integer nonlinear programming problems. This kind of problems have integer and continuous variables and they appear very frequently in process engineering problems. The objective of this work is to analyze the performance of the method when the coordinate searches are interrupted in the context of the multistart strategy. From the numerical experiments, we observed a reduction on the number of function evaluations and on the CPU time.

  8. Interruption Phenomenon in Intermediate-Frequency Vacuum Arc

    NASA Astrophysics Data System (ADS)

    Jiang, Yuan; Wu, Jianwen

    2016-03-01

    In the condition of the 3 mm gap, experiments for 360 Hz intermediate-frequency vacuum arc are carried out in interrupters with the diameters being 41 mm and with the contact materials being CuCr50 and Cu-W-WC alloy respectively. The results indicate that the contacts material is closely related to the breaking capacity of the vacuum interrupters and characteristics of an intermediate-frequency vacuum arc. For contacts with the same diameter, the breaking capacity of CuCr50 is better than that of Cu-W-WC. When the current fails to be interrupted, the arcs overflow the gap and present irregular performances in the first half wave. Consequently a voltage spike appears. More macroscopic metal droplets can be seen in the arc column between CuCr50 contacts because of the lower melting point. It is observed that the droplet emission is much more severe during arc reignition than that in the first half wave. It is much more conspicuous that the high frequency arc voltage noises appear in Cu-W-WC contacts when the vacuum arcs reignite, for higher temperature and stronger electronic emission ability of Cu-W-WC contacts. supported by National Natural Science Foundation of China (No. 51377007), Specialized Research Fund for the Doctoral Program of Higher Education of China (No. 20131102130006), and Fundamental Research Funds for the Central Universities of China

  9. ICDS database: interrupted CoDing sequences in prokaryotic genomes.

    PubMed

    Perrodou, Emmanuel; Deshayes, Caroline; Muller, Jean; Schaeffer, Christine; Van Dorsselaer, Alain; Ripp, Raymond; Poch, Olivier; Reyrat, Jean-Marc; Lecompte, Odile

    2006-01-01

    Unrecognized frameshifts, in-frame stop codons and sequencing errors lead to Interrupted CoDing Sequence (ICDS) that can seriously affect all subsequent steps of functional characterization, from in silico analysis to high-throughput proteomic projects. Here, we describe the Interrupted CoDing Sequence database containing ICDS detected by a similarity-based approach in 80 complete prokaryotic genomes. ICDS can be retrieved by species browsing or similarity searches via a web interface (http://www-bio3d-igbmc.u-strasbg.fr/ICDS/). The definition of each interrupted gene is provided as well as the ICDS genomic localization with the surrounding sequence. Furthermore, to facilitate the experimental characterization of ICDS, we propose optimized primers for re-sequencing purposes. The database will be regularly updated with additional data from ongoing sequenced genomes. Our strategy has been validated by three independent tests: (i) ICDS prediction on a benchmark of artificially created frameshifts, (ii) comparison of predicted ICDS and results obtained from the comparison of the two genomic sequences of Bacillus licheniformis strain ATCC 14580 and (iii) re-sequencing of 25 predicted ICDS of the recently sequenced genome of Mycobacterium smegmatis. This allows us to estimate the specificity and sensitivity (95 and 82%, respectively) of our program and the efficiency of primer determination. PMID:16381882

  10. "Just a Minute..."--Managing Interruptions in the Junior School Classroom.

    ERIC Educational Resources Information Center

    Varley, Helen M.; Busher, Hugh

    1989-01-01

    Presents information concerning the range of external interruptions experienced by junior high school teachers. Examines the ways in which interruptions become disruptions. Provides suggestions on how to manage these interruptions and discusses the difference between "proactive" and "reactive" class management. Finds that size of school has the…

  11. Interruption Management in the Intensive Care Unit: Predicting Resumption Times and Assessing Distributed Support

    ERIC Educational Resources Information Center

    Grundgeiger, Tobias; Sanderson, Penelope; MacDougall, Hamish G.; Venkatesh, Balasubramanian

    2010-01-01

    Interruptions are frequent in many work domains. Researchers in health care have started to study interruptions extensively, but their studies usually do not use a theoretically guided approach. Conversely, researchers conducting theoretically rich laboratory studies on interruptions have not usually investigated how effectively their findings…

  12. Interruption of the Tower of London Task: Support for a Goal-Activation Approach

    ERIC Educational Resources Information Center

    Hodgetts, Helen M.; Jones, Dylan M.

    2006-01-01

    Unexpected interruptions introduced during the execution phase of simple Tower of London problems incurred a time cost when the interrupted goal was retrieved, and this cost was exacerbated the longer the goal was suspended. Furthermore, time taken to retrieve goals was greater following a more complex interruption, indicating the processing…

  13. No evidence of relation between working memory and perception of interrupted speech in young adults.

    PubMed

    Nagaraj, Naveen K; Knapp, Andrea N

    2015-08-01

    Understanding interrupted speech requires top-down linguistic and cognitive restoration mechanisms. To investigate the relation between working memory (WM) and perception of interrupted speech, 20 young adults were asked to recognize sentences interrupted at 2 Hz, 8 Hz, and a combination of 2 and 8 Hz. WM was measured using automated reading and operation span tasks. Interestingly, the results presented here revealed no statistical relation between any of the interrupted speech recognition scores and WM scores. This finding is in agreement with previous findings that suggest greater reliance on linguistic factors relative to cognitive factors during perception of interrupted speech. PMID:26328740

  14. High-capacity single-pressure SF/sub 6/ interrupters. Final report

    SciTech Connect

    Rostron, J R; Berkebile, L E; Spindle, H E

    1983-05-01

    The object of this project was to design and develop a high-voltage, single-pressure, SF/sub 6/ interrupter with an interrupting capability of 120 kA at 145 kV with a continuous current rating of 5000 A and an interrupting time of 1.5 cycles or less. A second objective of 100 kA at 242 kV was added during the project. Mathematical models were used to extrapolate design requirements from existing data for 63 and 80 kA. Two model puffers, one liquid and the other gas, were designed and tested to obtain data at 100 kA. An interrupter, optimized on the basis of total prospective breaker cost, was designed using the mathematical models. A study was made of the construction materials to operate under the high-stress conditions in this interrupter. Existing high-speed movies of high-current arcs under double-flow conditions were analyzed to obtain more information for modeling the interrupter. The optimized interrupter design was built and tested. The interrupting capability confirmed calculations of predicted performance near current zero; however, the dielectric strength after interrupting these high-current arcs was not adequate for the 145-kV or the 242-kV ratings. The dielectric strength was reduced by hot gases flowing out of the interrupter. Valuable data have been obtained for modeling the SF/sub 6/ puffer interrupter for high currents.

  15. Interruptions of nurses' activities and patient safety: an integrative literature review1

    PubMed Central

    Monteiro, Cintia; Avelar, Ariane Ferreira Machado; Pedreira, Mavilde da Luz Gonçalves

    2015-01-01

    OBJECTIVES: to identify characteristics related to the interruption of nurses in professional practice, as well as to assess the implications of interruptions for patient safety. METHOD: integrative literature review. The following databases were searched: Pubmed/Medline, LILACS, SciELO and Cochrane Library, using the descriptors interruptions and patient safety. An initial date was not established, but the final date was December 31, 2013. A total of 29 papers met the inclusion criteria. RESULTS: all the papers included describe interruptions as a harmful factor for patient safety. Data analysis revealed three relevant categories: characteristics of interruptions, implications for patient safety, and interventions to minimize interruptions. CONCLUSION: interruptions favor the occurrence of errors in the health field. Therefore, there is a need for further studies to understand such a phenomenon and its effects on clinical practice. PMID:25806646

  16. What Interrupts Suicide Attempts in Men: A Qualitative Study.

    PubMed

    Player, Michael J; Proudfoot, Judy; Fogarty, Andrea; Whittle, Erin; Spurrier, Michael; Shand, Fiona; Christensen, Helen; Hadzi-Pavlovic, Dusan; Wilhelm, Kay

    2015-01-01

    Despite higher rates of suicide in men, there is a dearth of research examining the perspectives and experiences of males at risk of suicide, particularly in terms of understanding how interventions can be tailored to men's specific needs. The current study aimed to examine factors assisting, complicating or inhibiting interventions for men at risk, as well as outlining the roles of family, friends and others in male suicide prevention. Thirty-five male suicide survivors completed one-to-one interviews, and forty-seven family and friends of male suicide survivors participated in eight focus groups. Thematic analysis revealed five major themes: (1) development of suicidal behaviours tends to follow a common path associated with specific types of risk factors (disrupted mood, unhelpful stoic beliefs and values, avoidant coping strategies, stressors), (2) men at risk of suicide tend to systematically misinterpret changes in their behaviour and thinking, (3) understanding mood and behavioural changes in men enables identification of opportunities to interrupt suicide progression, (4) distraction, provision of practical and emotional supports, along with professional intervention may effectively interrupt acute risk of harm, and (5) suicidal ideation may be reduced through provision of practical help to manage crises, and helping men to focus on obligations and their role within families. Findings suggest that interventions for men at risk of suicidal behaviours need to be tailored to specific risk indicators, developmental factors, care needs and individuals' preferences. To our knowledge this is the first qualitative study to explore the experiences of both suicidal men and their family/friends after a suicide attempt, with the view to improve understanding of the processes which are effective in interrupting suicide and better inform interventions for men at risk. PMID:26090794

  17. What Interrupts Suicide Attempts in Men: A Qualitative Study

    PubMed Central

    Player, Michael J.; Proudfoot, Judy; Fogarty, Andrea; Whittle, Erin; Spurrier, Michael; Shand, Fiona; Christensen, Helen; Hadzi-Pavlovic, Dusan; Wilhelm, Kay

    2015-01-01

    Despite higher rates of suicide in men, there is a dearth of research examining the perspectives and experiences of males at risk of suicide, particularly in terms of understanding how interventions can be tailored to men’s specific needs. The current study aimed to examine factors assisting, complicating or inhibiting interventions for men at risk, as well as outlining the roles of family, friends and others in male suicide prevention. Thirty-five male suicide survivors completed one-to-one interviews, and forty-seven family and friends of male suicide survivors participated in eight focus groups. Thematic analysis revealed five major themes: (1) development of suicidal behaviours tends to follow a common path associated with specific types of risk factors (disrupted mood, unhelpful stoic beliefs and values, avoidant coping strategies, stressors), (2) men at risk of suicide tend to systematically misinterpret changes in their behaviour and thinking, (3) understanding mood and behavioural changes in men enables identification of opportunities to interrupt suicide progression, (4) distraction, provision of practical and emotional supports, along with professional intervention may effectively interrupt acute risk of harm, and (5) suicidal ideation may be reduced through provision of practical help to manage crises, and helping men to focus on obligations and their role within families. Findings suggest that interventions for men at risk of suicidal behaviours need to be tailored to specific risk indicators, developmental factors, care needs and individuals’ preferences. To our knowledge this is the first qualitative study to explore the experiences of both suicidal men and their family/friends after a suicide attempt, with the view to improve understanding of the processes which are effective in interrupting suicide and better inform interventions for men at risk. PMID:26090794

  18. A reevaluation of the interrupter technique for airway resistance measurement

    NASA Technical Reports Server (NTRS)

    Jackson, A. C.; Milhorn, H. T., Jr.; Norman, J. R.

    1974-01-01

    An attempt was made to obtain a better insight into the actual transient response of airway opening pressure (Pao) following rapid occlusion. With this knowledge it was hoped to be able to clarify the reason for the overestimations found by other investigators, and possibly to obtain a more accurate method of estimating alveolar pressure just prior to interruption. This would result in an improved method for estimating airway resistance. Use of an extrapolation method was found to provide an improved correlation between resistances determined by the interruptor technique and those found by the plethysmograph in normal subjects.

  19. Models for interrupted monitoring of a stochastic process

    NASA Technical Reports Server (NTRS)

    Palmer, E.

    1977-01-01

    As computers are added to the cockpit, the pilot's job is changing from of manually flying the aircraft, to one of supervising computers which are doing navigation, guidance and energy management calculations as well as automatically flying the aircraft. In this supervisorial role the pilot must divide his attention between monitoring the aircraft's performance and giving commands to the computer. Normative strategies are developed for tasks where the pilot must interrupt his monitoring of a stochastic process in order to attend to other duties. Results are given as to how characteristics of the stochastic process and the other tasks affect the optimal strategies.

  20. Left atrial thrombus formation after brief interruption of rivaroxaban.

    PubMed

    Turner, Matthew; Solarz, David

    2016-01-01

    Every year, nearly 250000 atrial fibrillation patients require temporary interruption of anticoagulation therapy for invasive procedures, acute illness, or bleeding events. Rivaroxaban is an oral anticoagulant that works by inhibiting factor Xa leading to a blockage of thrombin production, which inhibits platelet aggregation and thrombus formation. As with other anticoagulants, there is an increased risk of a thrombotic event occurring when rivaroxaban therapy is temporarily interrupted (TI) or prematurely discontinued. The 30-day rate of stroke or systemic embolism for rivaroxaban TI is 0.36%. Possible factors for higher than expected rates of embolic events include a prothrombotic perioperative environment among patients having TI for surgery and a prothrombotic environment associated with TI due to bleeding. The ROCKET AF study showed that there was no detectable difference in the risk of stroke and systemic embolism for participants treated with rivaroxaban vs warfarin undergoing TI. Another analysis suggested that the risk for stroke from TI is probably higher in the rivaroxaban group with 3 to 30 days discontinuation. Alternative anticoagulation therapy such as bridging should always be considered when stopping rivaroxaban. PMID:26081413

  1. The interrupted power law and the size of shadow banking.

    PubMed

    Fiaschi, Davide; Kondor, Imre; Marsili, Matteo; Volpati, Valerio

    2014-01-01

    Using public data (Forbes Global 2000) we show that the asset sizes for the largest global firms follow a Pareto distribution in an intermediate range, that is "interrupted" by a sharp cut-off in its upper tail, where it is totally dominated by financial firms. This flattening of the distribution contrasts with a large body of empirical literature which finds a Pareto distribution for firm sizes both across countries and over time. Pareto distributions are generally traced back to a mechanism of proportional random growth, based on a regime of constant returns to scale. This makes our findings of an "interrupted" Pareto distribution all the more puzzling, because we provide evidence that financial firms in our sample should operate in such a regime. We claim that the missing mass from the upper tail of the asset size distribution is a consequence of shadow banking activity and that it provides an (upper) estimate of the size of the shadow banking system. This estimate-which we propose as a shadow banking index-compares well with estimates of the Financial Stability Board until 2009, but it shows a sharper rise in shadow banking activity after 2010. Finally, we propose a proportional random growth model that reproduces the observed distribution, thereby providing a quantitative estimate of the intensity of shadow banking activity. PMID:24728096

  2. Series and parallel arc-fault circuit interrupter tests.

    SciTech Connect

    Johnson, Jay; Fresquez, Armando J.; Gudgel, Bob; Meares, Andrew

    2013-07-01

    While the 2011 National Electrical Code%C2%AE (NEC) only requires series arc-fault protection, some arc-fault circuit interrupter (AFCI) manufacturers are designing products to detect and mitigate both series and parallel arc-faults. Sandia National Laboratories (SNL) has extensively investigated the electrical differences of series and parallel arc-faults and has offered possible classification and mitigation solutions. As part of this effort, Sandia National Laboratories has collaborated with MidNite Solar to create and test a 24-string combiner box with an AFCI which detects, differentiates, and de-energizes series and parallel arc-faults. In the case of the MidNite AFCI prototype, series arc-faults are mitigated by opening the PV strings, whereas parallel arc-faults are mitigated by shorting the array. A range of different experimental series and parallel arc-fault tests with the MidNite combiner box were performed at the Distributed Energy Technologies Laboratory (DETL) at SNL in Albuquerque, NM. In all the tests, the prototype de-energized the arc-faults in the time period required by the arc-fault circuit interrupt testing standard, UL 1699B. The experimental tests confirm series and parallel arc-faults can be successfully mitigated with a combiner box-integrated solution.

  3. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption

    PubMed Central

    Hurst, Jacob; Hoffmann, Matthias; Pace, Matthew; Williams, James P.; Thornhill, John; Hamlyn, Elizabeth; Meyerowitz, Jodi; Willberg, Chris; Koelsch, Kersten K.; Robinson, Nicola; Brown, Helen; Fisher, Martin; Kinloch, Sabine; Cooper, David A.; Schechter, Mauro; Tambussi, Giuseppe; Fidler, Sarah; Babiker, Abdel; Weber, Jonathan; Kelleher, Anthony D.; Phillips, Rodney E.; Frater, John

    2015-01-01

    Treatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state of ‘post-treatment control' (PTC) in some patients, in whom viraemia remains undetectable when ART is stopped. Explaining PTC could help our understanding of the processes that maintain viral persistence. Here we show that immunological biomarkers can predict time to viral rebound after stopping ART by analysing data from a randomized study of primary HIV-1 infection incorporating a treatment interruption (TI) after 48 weeks of ART (the SPARTAC trial). T-cell exhaustion markers PD-1, Tim-3 and Lag-3 measured prior to ART strongly predict time to the return of viraemia. These data indicate that T-cell exhaustion markers may identify those latently infected cells with a higher proclivity to viral transcription. Our results may open new avenues for understanding the mechanisms underlying PTC, and eventually HIV-1 eradication. PMID:26449164

  4. Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.

    PubMed

    Hurst, Jacob; Hoffmann, Matthias; Pace, Matthew; Williams, James P; Thornhill, John; Hamlyn, Elizabeth; Meyerowitz, Jodi; Willberg, Chris; Koelsch, Kersten K; Robinson, Nicola; Brown, Helen; Fisher, Martin; Kinloch, Sabine; Cooper, David A; Schechter, Mauro; Tambussi, Giuseppe; Fidler, Sarah; Babiker, Abdel; Weber, Jonathan; Kelleher, Anthony D; Phillips, Rodney E; Frater, John

    2015-01-01

    Treatment of HIV-1 infection with antiretroviral therapy (ART) in the weeks following transmission may induce a state of 'post-treatment control' (PTC) in some patients, in whom viraemia remains undetectable when ART is stopped. Explaining PTC could help our understanding of the processes that maintain viral persistence. Here we show that immunological biomarkers can predict time to viral rebound after stopping ART by analysing data from a randomized study of primary HIV-1 infection incorporating a treatment interruption (TI) after 48 weeks of ART (the SPARTAC trial). T-cell exhaustion markers PD-1, Tim-3 and Lag-3 measured prior to ART strongly predict time to the return of viraemia. These data indicate that T-cell exhaustion markers may identify those latently infected cells with a higher proclivity to viral transcription. Our results may open new avenues for understanding the mechanisms underlying PTC, and eventually HIV-1 eradication. PMID:26449164

  5. Platelet count kinetics following interruption of antiretroviral treatment

    PubMed Central

    Zetterberg, Eva; Neuhaus, Jacqueline; Baker, Jason V.; Somboonwit, Charurut; Llibre, Josep M.; Palfreeman, Adrian; Chini, Maria; Lundgren, Jens D.

    2014-01-01

    Objectives To investigate the mechanisms of platelet kinetics in the Strategies for Management of Antiretroviral Therapy (SMART) study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) drug conservation compared with continuous treatment viral suppression. Follow-up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART. Design SMART patients from sites that determined platelets routinely. Methods Platelet counts were retrospectively collected from 2206 patients from visits at study entry, and during follow-up. D-dimer levels were measured at study entry, month 1, and 2. Results Platelet levels decreased in the drug conservation group following randomization, but remained stable in the viral suppression group [median (IQR) decline from study entry to month 4: −24 000/µl (−54 000 to 4000) vs. 3000 (−22 000 to 24 000), respectively, P < 0.0001)] and the rate of developing thrombocytopenia (<100 000/µl) was significantly higher in the drug conservation vs. the viral suppression arm (unadjusted drug conservation/viral suppression [HR (95%CI) = 1.8 (1.2–2.7)]. The decline in platelet count among drug conservation participants on fully suppressive ART correlated with the rise in D-dimer from study entry to either month 1 or 2 (r = −0.41; P = 0.02). Among drug conservation participants who resumed ART 74% recovered to their study entry platelet levels. Conclusion Interrupting ART increases the risk of thrombocytopenia, but reinitiation of ART typically reverses it. Factors contributing to declines in platelets after interrupting ART may include activation of coagulation pathways or HIV-1 replication itself. The contribution of platelets in HIV-related procoagulant activity requires further study. PMID:23018440

  6. Effects of Modality on Interrupted Flight Deck Performance: Implications for Data Link

    NASA Technical Reports Server (NTRS)

    Latorella, Kara A.

    1997-01-01

    Externally-imposed tasks frequently interrupt ongoing task performance in the commercial flight deck. While normally managed without consequence, basic research as well as aviation accident and incident investigations show that interruptions can negatively affect performance and safety. This research investigates the influence of interruption and interrupted task modality on pilot performance in a simulated commercial flight deck. Fourteen current commercial airline pilots performed approach scenarios in a fixed-base flight simulator. Air traffic control instructions, conveyed either aurally or visually (via a data link system) interrupted a visual task (obtaining information from the Flight Management System) and an auditory task (listening to the automated terminal information service recording). Some results confirm the hypothesized performance advantage of cross-modality conditions, more compelling nature of auditory interruptions, and interruption-resistance of auditory ongoing tasks. However, taken together, results suggest the four interaction conditions had different effects on pilot performance. These results have implications for the design of data link systems, and for facilitating interruption management through interface design, aiding, and training programs.

  7. 33 CFR 159.89 - Power interruption: Type I and II devices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... SECURITY (CONTINUED) POLLUTION MARINE SANITATION DEVICES Design, Construction, and Testing § 159.89 Power interruption: Type I and II devices. A discharge device must be designed so that a momentary loss of power... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Power interruption: Type I and...

  8. Real time interrupt handling using FORTRAN IV plus under RSX-11M

    SciTech Connect

    Schultz, D.E.

    1981-01-01

    A real-time data acquisition application for a linear accelerator is described. The important programming features of this application are use of connect to interrupt, a shared library, map to I/O page, and a shared data area. How you can provide rapid interrupt handling using these tools from FORTRAN IV PLUS is explained.

  9. Auditory training of speech recognition with interrupted and continuous noise maskers by children with hearing impairment

    PubMed Central

    Sullivan, Jessica R.; Thibodeau, Linda M.; Assmann, Peter F.

    2013-01-01

    Previous studies have indicated that individuals with normal hearing (NH) experience a perceptual advantage for speech recognition in interrupted noise compared to continuous noise. In contrast, adults with hearing impairment (HI) and younger children with NH receive a minimal benefit. The objective of this investigation was to assess whether auditory training in interrupted noise would improve speech recognition in noise for children with HI and perhaps enhance their utilization of glimpsing skills. A partially-repeated measures design was used to evaluate the effectiveness of seven 1-h sessions of auditory training in interrupted and continuous noise. Speech recognition scores in interrupted and continuous noise were obtained from pre-, post-, and 3 months post-training from 24 children with moderate-to-severe hearing loss. Children who participated in auditory training in interrupted noise demonstrated a significantly greater improvement in speech recognition compared to those who trained in continuous noise. Those who trained in interrupted noise demonstrated similar improvements in both noise conditions while those who trained in continuous noise only showed modest improvements in the interrupted noise condition. This study presents direct evidence that auditory training in interrupted noise can be beneficial in improving speech recognition in noise for children with HI. PMID:23297921

  10. Causal Inference and the Comparative Interrupted Time Series Design: Findings from Within-Study Comparisons

    ERIC Educational Resources Information Center

    St. Clair, Travis; Hallberg, Kelly; Cook, Thomas D.

    2014-01-01

    Researchers are increasingly using comparative interrupted time series (CITS) designs to estimate the effects of programs and policies when randomized controlled trials are not feasible. In a simple interrupted time series design, researchers compare the pre-treatment values of a treatment group time series to post-treatment values in order to…

  11. Interruptions and Failure in Higher Education: Evidence from ISEG-UTL

    ERIC Educational Resources Information Center

    Chagas, Margarida; Fernandaes, Graca Leao

    2011-01-01

    Failure in higher education (HE) is the outcome of multiple time-dependent determinants. Interruptions in students' individual school trajectories are one of them, and that is why research on this topic has been attracting much attention these days. From an individual point of view, it is expected that interruptions in school trajectory, whatever…

  12. 76 FR 35014 - Certain Ground Fault Circuit Interrupters and Products Containing Same; Notice of Commission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... Leviton Manufacturing Co. (``Leviton'') of Melville, New York. 75 FR 62420 (Oct. 8, 2010). The complaint... COMMISSION Certain Ground Fault Circuit Interrupters and Products Containing Same; Notice of Commission... importation of certain ground fault circuit interrupters and products containing the same by reason...

  13. 14 CFR 323.14 - Temporary suspension authority for involuntary interruption of service.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Temporary suspension authority for involuntary interruption of service. 323.14 Section 323.14 Aeronautics and Space OFFICE OF THE SECRETARY... REDUCTIONS OF SERVICE § 323.14 Temporary suspension authority for involuntary interruption of service....

  14. 14 CFR 323.14 - Temporary suspension authority for involuntary interruption of service.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Temporary suspension authority for involuntary interruption of service. 323.14 Section 323.14 Aeronautics and Space OFFICE OF THE SECRETARY... REDUCTIONS OF SERVICE § 323.14 Temporary suspension authority for involuntary interruption of service....

  15. 14 CFR 323.14 - Temporary suspension authority for involuntary interruption of service.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Temporary suspension authority for involuntary interruption of service. 323.14 Section 323.14 Aeronautics and Space OFFICE OF THE SECRETARY... REDUCTIONS OF SERVICE § 323.14 Temporary suspension authority for involuntary interruption of service....

  16. 14 CFR 323.14 - Temporary suspension authority for involuntary interruption of service.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Temporary suspension authority for involuntary interruption of service. 323.14 Section 323.14 Aeronautics and Space OFFICE OF THE SECRETARY... REDUCTIONS OF SERVICE § 323.14 Temporary suspension authority for involuntary interruption of service....

  17. 14 CFR 323.14 - Temporary suspension authority for involuntary interruption of service.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Temporary suspension authority for involuntary interruption of service. 323.14 Section 323.14 Aeronautics and Space OFFICE OF THE SECRETARY... REDUCTIONS OF SERVICE § 323.14 Temporary suspension authority for involuntary interruption of service....

  18. Unemployment and Work Interruption among African American Single Mothers: Effects on Parenting and Adolescent Socioemotional Functioning.

    ERIC Educational Resources Information Center

    McLoyd, Vonnie C.; And Others

    1994-01-01

    Using interview data from 241 single African American mothers and their seventh- and eighth-grade children, this study tested a model of how 2 economic stressors, maternal unemployment and work interruption, influenced adolescent socioemotional functioning. Found that current unemployment, but not past work interruption, contributed to depressive…

  19. Discourse Markers in Turn-Initial Positions in Interruptive Speech in a Malaysian Radio Discourse

    ERIC Educational Resources Information Center

    Nor, Siti Nurbaya Mohd

    2012-01-01

    Discourse markers play significant roles in any spoken interaction. This research examines the functions of the discourse markers (DMs) well, now and and used as turn-initial interruptive devices in a Malaysian radio discourse. Using Schegloff's (2002) framework of what constitutes an interruption in turn-taking and previous studies on the…

  20. Prospective Memory in Children: The Effects of Age and Task Interruption.

    ERIC Educational Resources Information Center

    Kvavilashvili, Lia; Messer, David J.; Ebdon, Pippa

    2001-01-01

    Three experiments examined effects of age and task interruption on children's prospective memory (PM), remembering to carry out a future task. Age explained a small portion of variance in performance. Children who did not have to interrupt their ongoing activity to complete the PM tasks performed significantly better than children who had to…

  1. Towards a Politics of Interruption: High School Design as Politically Relevant Pedagogy

    ERIC Educational Resources Information Center

    Stovall, David

    2007-01-01

    The following essay seeks to highlight the use of engaged qualitative community-based research in education to respond to conditions of structural inequality. As "the politics of interruption", the process of creating neighborhood public high schools is centred in community accountability. Responsibility in this mode "interrupts" the resurgence of…

  2. Balancing eldercare and employment: the role of work interruptions and supportive employers.

    PubMed

    Kim, Jeungkun; Ingersoll-Dayton, Berit; Kwak, Minyoung

    2013-04-01

    This study investigates pathways by which employed caregivers' stress is related to their work performance appraisal, with particular attention to work interruptions and supportive employers. Based on a nationally representative sample from the 2004 National Long-Term Care Survey (NLTCS), the study focuses on caregivers to older adults who are currently participating in paid employment (N = 652). Results from structural equation modeling indicate that work interruptions mediate the relationship between caregivers' stress and their work performance appraisal. In addition, the support of employers moderates the relationship between employed caregivers' stress and their work interruptions as well as the relationship between their work interruptions and work performance appraisal. These results point to the need for training supervisors and helping them to understand the potential dual effects of their support on employed caregivers' work interruptions and performance. PMID:25474393

  3. [Video-assisted Thoracoscopic Interruption of Patent Ductus Arteriosus].

    PubMed

    Miyaji, Kagami

    2016-07-01

    Between, 2000 and 2015, for 200 patients video-assisted thoracic surgery (VATS)-patent ductus arteriosus (PDA) has been performed, including 130 infants and children, and 70 low birth weight babies. Robotically assisted procedure was used in 105 patients. The mean age was 10 months, and body weight was 5.3 kg, ranged from 420 g to 61 kg. The mean procedure time was 48 min, ranged from 20 to 180 min. The size of PDA was around 5 mm in diameter. Conversion to thoracotomy was 4 cases. There were 2 haspital deaths(1.0%), both of extremely low birth weight patients. There were 9 major complications, including residual shunt in 5. The coil embolization were performed in 4 patients,and thoracotomy was in 1 patient. There were 2 chylothorax, for whom VATS ligation of thoracic duct was performed. In concluson, Video-assisted thoracoscopic interruption for PDA (VATS-PDA) has been performed for consecutive 200 patients with excellent results. VATS-PDA is safe, effective, and minimally traumatic, even for extremely low birth weight patients. PMID:27440022

  4. Interruption of malaria transmission by chloroquinized salt in Guyana

    PubMed Central

    Giglioli, George; Rutten, Frans J.; Ramjattan, S.

    1967-01-01

    Malaria and its local vector, Anopheles darlingi, were eradicated from the coastlands and near interior of Guyana by DDT house-spraying in 1945-51. In the remote interior, where 10% of the population live, only partial control could be achieved, owing to the semi-silvatic habits of A. darlingi and the considerable movement of the sparse population; low malaria endemicity persisted in these areas with occasional localized outbreaks. In the south-west the problem was further complicated by the presence of malaria across the frontier. During the years 1961-65, the use of chloroquinized salt was made compulsory over an area of some 109 000 km2, covering a population of 48 500. Satisfactory results were obtained over 84% of this area within 6 months of the start of the campaign; only four cases of malaria were seen in four years. In the south-west, however, an initially favourable trend was reversed in 1962 with the introduction of a chloroquine-resistant strain of Plasmodium falciparum from Brazil. The situation was brought under control by house-spraying with DDT and interruption of transmission is expected. PMID:4864651

  5. ICE System: Interruptible control expert system. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Vezina, James M.

    1990-01-01

    The Interruptible Control Expert (ICE) System is based on an architecture designed to provide a strong foundation for real-time production rule expert systems. Three principles are adopted to guide the development of ICE. A practical delivery platform must be provided, no specialized hardware can be used to solve deficiencies in the software design. Knowledge of the environment and the rule-base is exploited to improve the performance of a delivered system. The third principle of ICE is to respond to the most critical event, at the expense of the more trivial tasks. Minimal time is spent on classifying the potential importance of environmental events with the majority of the time used for finding the responses. A feature of the system, derived from all three principles, is the lack of working memory. By using a priori information, a fixed amount of memory can be specified for the hardware platform. The absence of working memory removes the dangers of garbage collection during the continuous operation of the controller.

  6. [Ethical dilemmas in medicine. The interruption of pregnancy in woman].

    PubMed

    Gual-Castro, Carlos

    2016-01-01

    Pregnancy interruption or abortion may be spontaneous or induced for medical, legal, demographic, and personal reasons. Different events that are present during the woman´s gravid period were described, paying attention to the differences in between fertilization and conception. These issues are very important because people or institutions mix these concepts and posit that pregnancy or conception starts at fertilization in opposition to the actual medical and scientific knowledge. In Mexico there are several millions of spontaneous and induced abortions without medical care, responsible for the high maternal-infant mortality rates. To avoid this undesirable situation, it has been proposed to follow the established WHO guidelines and adopt national health policies to re-orientate population goals on life quality, gender equity, universal public health services, and to promote the new holistic concepts of reproductive and sexual health such as: family planning, use of anti-fertility methods, adolescent reproductive health, sexually transmitted diseases, maternal and newborn health, peri- and post-menopausal women's health, and prevention, diagnosis, and opportune treatment of mammary, cervical-uterine, and ovarian cancers. Finally, it is recommended to revise our national health policies and existing laws on abortion de-penalization. PMID:27595258

  7. Execution-Based Model Checking of Interrupt-Based Systems

    NASA Technical Reports Server (NTRS)

    Drusinsky, Doron; Havelund, Klaus

    2003-01-01

    Execution-based model checking (EMC) is a verification technique based on executing a multi-threaded/multiprocess program repeatedly in a systematic manner in order to explore the different interleavings of the program. This is in contrast to traditional model checking, where a model of a system is analyzed Several execution-based model-checking tools exist at this point, such as for example Verisoft and Java PathFinder. The most common formal specification languages used by EMC tools are un- timed, either just assertions, or linear-time temporal logic (LTL). An alternative verification technique is Runtime Execution Monitoring (REM), which is based on monitor- ing the execution of a program, checking that the execution trace conforms to a requirement specification. The Temporal Rover and DBRover are such tools. They provide a very rich specification language, being an extension of LTL with real-time constraints and time-series. We show how execution-based model checking, combined with runtime execution monitoring, can be used for the verification of a large class of safety critical systems commonly known as interrupt-based systems. The proposed approach is novel in that: (i) it supports model checking of a large class of applications not practically verifiable using conventional EMC tools, (ii) it supports verification of LTL assertions extended with real-time and time-series constraints, and (iii) it supports the verification of custom schedulers.

  8. Roads, interrupted dispersal, and genetic diversity in timber rattlesnakes.

    PubMed

    Clark, Rulon W; Brown, William S; Stechert, Randy; Zamudio, Kelly R

    2010-08-01

    Anthropogenic habitat modification often creates barriers to animal movement, transforming formerly contiguous habitat into a patchwork of habitat islands with low connectivity. Roadways are a feature of most landscapes that can act as barriers or filters to migration among local populations. Even small and recently constructed roads can have a significant impact on population genetic structure of some species, but not others. We developed a research approach that combines fine-scale molecular genetics with behavioral and ecological data to understand the impacts of roads on population structure and connectivity. We used microsatellite markers to characterize genetic variation within and among populations of timber rattlesnakes (Crotalus horridus) occupying communal hibernacula (dens) in regions bisected by roadways. We examined the impact of roads on seasonal migration, genetic diversity, and gene flow among populations. Snakes in hibernacula isolated by roads had significantly lower genetic diversity and higher genetic differentiation than snakes in hibernacula in contiguous habitat. Genetic-assignment analyses revealed that interruption to seasonal migration was the mechanism underlying these patterns. Our results underscore the sizeable impact of roads on this species, despite their relatively recent construction at our study sites (7 to 10 generations of rattlesnakes), the utility of population genetics for studies of road ecology, and the need for mitigating effects of roads. PMID:20151984

  9. Current interruption and particle beam generation by a plasma focus

    NASA Astrophysics Data System (ADS)

    Gerdin, G.; Venneri, F.

    1982-11-01

    Through collaboration with Dr. K. H. Schoenbach of Texas Tech University the plasma focus opening switch (PFOS) was revised to answer basic questions as to utility of the concept. To estimate the plasma temperature and classical resistivity a soft X-ray spectrometer and X-ray pinhole camera were developed. The temperature was estimated from a coronal model to range between 0.4 to 0.5 keV for either a nitrogen or neon impurity (1 to 2%) in deuterium at 3 torr. Strong pinches were observed in pure neon (0.6 torr) with an electron temperature in the same range. The corresponding classical resistance of the pinch is 9 m omega whereas 500 m omega is more consistent with output voltage pulse and current flow at interruption indicating anomalous resistivity is present. A one-dimensional two-fluid computer code has been developed to model anomalous resistivity in the pinch phase and preliminary results are consistent with the snowplow model. The final analysis of the plasma focus particle beam generation experiments was completed and a strong correlation was found for the beam-target model as the mechanism for neutron production in the Illinois plasma focus device.

  10. Ocular motor anatomy in a case of interrupted saccades.

    PubMed

    Rucker, Janet C; Leigh, R John; Optican, Lance M; Keller, Edward L; Bu Ttner-Ennever, Jean A

    2008-01-01

    Saccades normally place the eye on target with one smooth movement. In late-onset Tay-Sachs (LOTS), intrasaccadic transient decelerations occur that may result from (1) premature omnipause neuron (OPN) re-activation due to malfunction of the latch circuit that inhibits OPNs for the duration of the saccade or (2) premature inhibitory burst neuron (IBN) activation due to fastigial nucleus (FN) dysregulation by the dorsal cerebellar vermis. Neuroanatomic analysis of a LOTS brain was performed. Purkinje cells were absent and gliosis of the granular cell layer was present in the dorsal cerebellar vermis. Deep cerebellar nuclei contained large inclusions. IBNs were present with small inclusions. The sample did not contain the complete OPN region; however, neurons in the OPN region contained massive inclusions. Pathologic findings suggest that premature OPN re-activation and/or inappropriate firing of IBNs may be responsible for interrupted saccades in LOTS. Cerebellar clinical dysfunction, lack of saccadic slowing, and significant loss of cerebellar cells suggest that the second cause is more likely. PMID:18718354

  11. University students' attitudes towards Voluntary Interruption of Pregnancy.

    PubMed

    Rodríguez-Calvo, María Sol; Martínez-Silva, Isabel María; Soto, José Luis; Concheiro, Luis; Muñoz-Barús, José Ignacio

    2012-07-01

    An evaluation of the future professional trends was performed by analyzing the attitudes of university students to the Voluntary Interruption of Pregnancy (VIP). An anonymous questionnaire was distributed to 300 students (Medicine, Nursing and Law) of the University of Santiago de Compostela, with questions on their personal beliefs, opinion on the law and intention to participate in VIP. Of the 245 respondents (response rate 82%), 66.5% were pro-abortion and their attitudes towards VIP were consistent with their opinion on the beginning of life and with the ethical arguments related to the fetus and the mother. No differences were found with age, sex or degree. The students showed to be well informed on the VIP law, and the majority of them considered unsuitable termination of pregnancy in minors without parental consent. Students' intentions to take part in abortion provision were influenced by their views on abortion, level of participation and circumstances of pregnancy. Although the majority of participants would be willing to perform VIP in situations that affect fetus and mother's life or health (87-66%), their intentions clearly diminished in other situations, such as abortion on demand (17%). These data suggest that conscientious objection of health professionals can even increase with the new policy, a fact that might affect VIP availability. It is important to stress the need of ethical training to help in the solution of conflicts between patient and health professional values. PMID:22498236

  12. Trastuzumab interruption and treatment-induced cardiotoxicity in early HER2-positive breast cancer

    PubMed Central

    Yu, Anthony F.; Yadav, Nandini U.; Lung, Betty Y.; Eaton, Anne A.; Thaler, Howard T.; Hudis, Clifford A.; Dang, Chau T.; Steingart, Richard M.

    2016-01-01

    Trastuzumab improves outcomes among patients with HER2-positive breast cancer but is associated with a risk of treatment-induced cardiotoxicity (TIC). It is unclear how frequently TIC leads to trastuzumab interruption outside of prospective trials, and how TIC is managed in clinical practice. Patients with HER2-postive breast cancer receiving adjuvant trastuzumab from 2005 to 2010 were identified (n = 608). We evaluated the incidence, risk factors, and management of trastuzumab interruption due to TIC. In total, 488 (80 %) patients were treated with anthracycline prior to trastuzumab. Trastuzumab was interrupted in 108 (18 %) patients. Cumulative trastuzumab dose was lower in the interrupted group (median 86 vs. 108 mg/kg, p<0.0001). The most common reason for interruption was TIC (66 of 108 patients): 20 had symptomatic heart failure and 46 had asymptomatic left ventricular ejection fraction (LVEF) decline. Patients with trastuzumab interruption for TIC were older (54 vs. 50 years, p = 0.014) with lower LVEF before anthracycline (63 vs. 67 %, p<0.0001) and trastuzumab (62 vs. 67 %, p<0.0001) therapy. Mean LVEF at baseline, TIC diagnosis, and follow-up after trastuzumab interruption was 63, 45, and 55 %, respectively. Thirty-three of 66 patients with TIC were re-challenged with trastuzumab, and five patients had recurrent LVEF decline. In clinical practice, trastuzumab interruption is common and most often due to TIC, with most patients receiving anthracycline prior to trastuzumab. Cardiac dysfunction improves after trastuzumab interruption but may not fully recover to baseline. Strategies to minimize cardiotoxicity and treatment interruption should be investigated to prevent persistent left ventricular dysfunction in affected patients. PMID:25552363

  13. Interrupting Anticoagulation in Patients With Nonvalvular Atrial Fibrillation

    PubMed Central

    Yates, Scott W.

    2014-01-01

    Three target-specific oral anticoagulants (TSOACs)—dabigatran, rivaroxaban, and apixaban—have been approved by the FDA to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation; however, no agents are currently approved to reverse the anticoagulant effects of these TSOACs in cases of active bleeding. This review discusses the benefits and risks of these TSOACs from a clinician’s perspective, with a focus on the interruption of treatment for either elective or emergent surgery, monitoring, and reversal of anticoagulation. Available coagulation assays are not ideal for monitoring the effects of TSOACs and do not provide reliable quantitative measurement of their anticoagulant effects. When necessary, activated partial thromboplastin time (aPTT) may provide qualitative information on dabigatran, and prothrombin time (PT) may provide qualitative assessment of the presence of the factor Xa inhibitors, rivaroxaban and apixaban. Current recommendations for reversal of TSOACs are based largely on limited and sometimes conflicting data from in vitro or in vivo animal models, and clinical experience with these recommendations is also limited. Methods that have been investigated for effectiveness for reversal of the pharmacodynamic effects of the TSOACs include dialysis, activated charcoal, prothrombin complex concentrate (PCC), and recombinant activated factor VII. It is important to note that even within a class of anticoagulant drugs, compounds respond differently to reversal agents; therefore, recommendations for one agent should not be extrapolated to another, even if they are from the same therapeutic class. New antidotes are being explored, including a mouse monoclonal antibody to dabigatran; andexanet alfa, a potential universal factor Xa inhibitor reversal agent; and a synthetic small molecule (PER977) that may be effective for the reversal of factor Xa inhibitors and direct thrombin inhibitors. Given the short half

  14. SOHO Mission Interruption Joint NASA/ESA Investigation Board

    NASA Technical Reports Server (NTRS)

    1998-01-01

    Contact with the SOlar Heliospheric Observatory (SOHO) spacecraft was lost in the early morning hours of June 25, 1998, Eastern Daylight Time (EDT), during a planned period of calibrations, maneuvers, and spacecraft reconfigurations. Prior to this the SOHO operations team had concluded two years of extremely successful science operations. A joint European Space Agency (ESA)/National Aeronautics and Space Administration (NASA) engineering team has been planning and executing recovery efforts since loss of contact with some success to date. ESA and NASA management established the SOHO Mission Interruption Joint Investigation Board to determine the actual or probable cause(s) of the SOHO spacecraft mishap. The Board has concluded that there were no anomalies on-board the SOHO spacecraft but that a number of ground errors led to the major loss of attitude experienced by the spacecraft. The Board finds that the loss of the SOHO spacecraft was a direct result of operational errors, a failure to adequately monitor spacecraft status, and an erroneous decision which disabled part of the on-board autonomous failure detection. Further, following the occurrence of the emergency situation, the Board finds that insufficient time was taken by the operations team to fully assess the spacecraft status prior to initiating recovery operations. The Board discovered that a number of factors contributed to the circumstances that allowed the direct causes to occur. The Board strongly recommends that the two Agencies proceed immediately with a comprehensive review of SOHO operations addressing issues in the ground procedures, procedure implementation, management structure and process, and ground systems. This review process should be completed and process improvements initiated prior to the resumption of SOHO normal operations.

  15. Effects of age and hearing loss on the intelligibility of interrupted speecha)

    PubMed Central

    Shafiro, Valeriy; Sheft, Stanley; Risley, Robert; Gygi, Brian

    2015-01-01

    How age and hearing loss affect the perception of interrupted speech may vary based on both the physical properties of preserved or obliterated speech fragments and individual listener characteristics. To investigate perceptual processes and interruption parameters influencing intelligibility across interruption rates, participants of different age and hearing status heard sentences interrupted by silence at either a single primary rate (0.5–8 Hz; 25%, 50%, 75% duty cycle) or at an additional concurrent secondary rate (24 Hz; 50% duty cycle). Although age and hearing loss significantly affected intelligibility, the ability to integrate sub-phonemic speech fragments produced by the fast secondary rate was similar in all listener groups. Age and hearing loss interacted with rate with smallest group differences observed at the lowest and highest interruption rates of 0.5 and 24 Hz. Furthermore, intelligibility of dual-rate gated sentences was higher than single-rate gated sentences with the same proportion of retained speech. Correlations of intelligibility of interrupted speech to pure-tone thresholds, age, or measures of working memory and auditory spectro-temporal pattern discrimination were generally low-to-moderate and mostly nonsignificant. These findings demonstrate rate-dependent effects of age and hearing loss on the perception of interrupted speech, suggesting complex interactions of perceptual processes across different time scales. PMID:25698009

  16. Management of antipsychotic treatment discontinuation and interruptions using model-based simulations

    PubMed Central

    Samtani, Mahesh N; Sheehan, John J; Fu, Dong-Jing; Remmerie, Bart; Sliwa, Jennifer Kern; Alphs, Larry

    2012-01-01

    Background Medication nonadherence is a well described and prevalent clinical occurrence in schizophrenia. These pharmacokinetic model-based simulations analyze predicted antipsychotic plasma concentrations in nonadherence and treatment interruption scenarios and with treatment reinitiation. Methods Starting from steady state, pharmacokinetic model-based simulations of active moiety plasma concentrations of oral, immediate-release risperidone 3 mg/day, risperidone long-acting injection 37.5 mg/14 days, oral paliperidone extended-release 6 mg/day, and paliperidone palmitate 117 mg (75 mg equivalents)/28 days were assessed under three treatment discontinuation/interruption scenarios, ie, complete discontinuation, one week of interruption, and four weeks of interruption. In the treatment interruption scenarios, pharmacokinetic simulations were performed using medication-specific reinitiation strategies. Results Following complete treatment discontinuation, plasma concentrations persisted longest with paliperidone palmitate, followed by risperidone long-acting injection, while oral formulations exhibited the most rapid decrease. One week of oral paliperidone or risperidone interruption resulted in near complete elimination from the systemic circulation within that timeframe, reflecting the rapid elimination rate of the active moiety. After 1 and 4 weeks of interruption, minimum plasma concentrations were higher with paliperidone palmitate than risperidone long-acting injection over the simulated period. Four weeks of treatment interruption followed by reinitiation resulted in plasma levels returning to predicted therapeutic levels within 1 week. Conclusion Due to the long half-life of paliperidone palmitate (25–49 days), putative therapeutic plasma concentrations persisted longest in simulated cases of complete discontinuation or treatment interruption. These simulations may help clinicians better conceptualize the impact of antipsychotic nonadherence on plasma

  17. The use of contingent-interrupted music in the treatment of disruptive bus-riding behavior.

    PubMed

    Barmann, B C; Croyle-Barmann, C; McLain, B

    1980-01-01

    The present study evaluated the efficacy of using contingent-interrupted music in treating the disruptive bus-riding behavior of an 8-year-old profoundly retarded female. Music was played during each bus ride as long as the subject was sitting appropriately, and interrupted contingent upon each response defined as disruptive bus riding, during an ABCDCDCDA design. A significant reduction in disruptive bus riding occurred with each introduction of contingent-interrupted music. The treatment procedure described in this report was easy to administer, produced rapid treatment gains, and showed virtually no regression during an 8-week follow-up period. PMID:7204285

  18. Influence of male gonadal hormones and familiarity on pregnancy interruption in prairie voles.

    PubMed

    Smale, L

    1988-08-01

    Pregnancy interruption (PI) was examined in female prairie voles, Microtus ochrogaster, exposed to stimuli from males 7 to 12 days after pairing. Urine from unfamiliar males interrupted pregnancy when placed directly on the external nares of newly mated females, but urine from familiar stud males was without effect. Castration of males did not reduce the efficacy of unfamiliar male urine in interrupting pregnancy. The neuroendocrine system of female prairie voles responded selectively to male urine as a function of its familiarity; the efficacy of male stimuli leading to PI was not dependent on gonadal hormones. PMID:3061485

  19. An Assessment of Instant Messaging Interruptions on Knowledge Workers' Task Performance in E-Learning-Based Training

    ERIC Educational Resources Information Center

    Mansi, Gary R.

    2011-01-01

    The modern workplace environment is filled with interruptions due to the necessity of coworkers to communicate with each other. Studies have revealed that interruptions can disrupt the ability of a knowledge worker to concentrate on a task, which can impact task performance (TP). Communication interruptions are due, in part, to the unavoidable…

  20. Interruption of Onchocerca volvulus transmission in Northern Venezuela

    PubMed Central

    2013-01-01

    Background Onchocerciasis is caused by Onchocerca volvulus and transmitted by Simulium species (black flies). In the Americas, the infection has been previously described in 13 discrete regional foci distributed among six countries (Brazil, Colombia, Ecuador, Guatemala, Mexico and Venezuela) where more than 370,000 people are currently considered at risk. Since 2001, disease control in Venezuela has relied on the mass drug administration to the at-risk communities. This report provides empirical evidence of interruption of Onchocerca volvulus transmission by Simulium metallicum in 510 endemic communities from two Northern foci of Venezuela, after 10–12 years of 6-monthly Mectizan® (ivermectin) treatment to all the eligible residents. Methods In-depth entomologic and epidemiologic surveys were serially conducted from 2001–2012 in selected (sentinel and extra-sentinel) communities from the North-central (NC) and North-east (NE) onchocerciasis foci of Venezuela in order to monitor the impact of ivermectin treatment. Results From 2007–2009, entomological indicators in both foci confirmed that 0 out of 112,637 S. metallicum females examined by PCR contained L3 infection in insect heads. The upper bound of the 95% confidence intervals of the infective rate of the vector reached values below 1% by 2009 (NC) and 2012 (NE). Additionally, after 14 (NC) and 22 (NE) rounds of treatment, the seasonal transmission potential (±UL CIs) of S. metallicum was under the critical threshold of 20 L3 per person per season. Serological analysis in school children < 15 years-old demonstrated that 0 out of 6,590 individuals were harboring antibodies to Ov-16. Finally, epidemiological surveys made during 2010 (NC) and 2012 (NE) showed no evidence of microfilariae in the skin and eyes of the population. Conclusions These results meet the WHO criteria for absence of parasite transmission and disease morbidity in these endemic areas which represent 91% of the population previously at

  1. Power spectra for both interrupted and perennial aging processes.

    PubMed

    Lukovic, Mirko; Grigolini, Paolo

    2008-11-14

    We study the power spectrum of a random telegraphic noise with the distribution density of waiting times tau given by psi(tau) proportional to 1tau(mu), with mu approximately 2. The condition mu<2 violates the ergodic hypothesis, and in this case the adoption of Wiener-Khintchine (WK) theorem for the spectrum evaluation requires some caution. We study this problem theoretically and numerically and we prove that the power spectrum obeys the prescription S(f)=Kf(eta), with eta=3-mu, namely, the 1f noise lives at border between the ergodic mu>2 and nonergodic mu<2 condition. We study sequences with the finite length L. In the case mu<2 the adoption of WK theorem is made legitimate by two different kinds of truncation effects: the physical and observation-induced effect. In the former case psi(tau) is truncated at tau approximately T(max) and L>T(max) ensures the condition of interrupted aging. In this case, we find that K is a number independent of L. The latter case, L2. We do not limit our treatment to the time asymptotic case, thereby producing a prediction that accounts for the transition from the 1f(eta) to the 1f(2) regime, recently observed in an experiment on blinking quantum dots. Our theoretical approach allows us to discuss some other recent experiments on molecular intermittent fluorescence and affords indications that should help to assess whether the spectrum is determined by the LT(max) condition. PMID:19045381

  2. Electric Power Interruption Cost Estimates for Individual Industries, Sectors and the U.S. Economy

    SciTech Connect

    Balducci, Patrick J.; Roop, Joseph M.; Schienbein, Lawrence A.; DeSteese, John G.; Weimar, Mark R.

    2003-05-16

    Distributed energy resources (DER) have been promoted as the least-cost approach to meeting steadily increasing energy demand. However, it is unclear whether DER deployment can maintain or improve the electric power supply reliability and quality currently available to consumers. This report addresses two key factors relating to this question: 1) characteristics of existing power supply reliability, and 2) costs resulting from supply interruptions characteristic of the existing power grid. Interruption cost data collected by the University of Saskatchewan was used in conjunction with data generated by the United States Department of Energy’s Annual Survey of Manufacturers, along with industry shares of gross domestic product (GDP) and gross output to derive interruption cost estimates for U.S. industries at the 2-digit Standard Industrial Classification (SIC) level. Interruption cost estimates are presented as a function of outage duration (e.g., 20 minutes, 1-hour, 3-hour), and are normalized in terms of dollars per peak kW.

  3. Assessment and treatment of problem behavior occasioned by interruption of free-operant behavior.

    PubMed

    Hagopian, Louis P; Bruzek, Jennifer L; Bowman, Lynn G; Jennett, Heather K

    2007-01-01

    The current study describes the assessment and treatment of the problem behavior of 3 individuals with autism for whom initial functional analysis results were inconclusive. Subsequent analyses revealed that the interruption of free-operant behavior using "do" requests (Study 1) as well as "do" and "don't" requests (Study 2) occasioned problem behavior. Initially, treatment involved differential and noncontingent reinforcement without interruption. To make the intervention more sustainable in the natural environment (where interruptions are unavoidable), a two-component multiple-schedule arrangement was used to progressively increase the period of time in which ongoing activities would be interrupted. During generalization sessions, the intervention was applied across a variety of contexts and therapists. PMID:17471795

  4. Functional Interrupts and Destructive Failures from Single Event Effect Testing of Point-Of-Load Devices

    NASA Technical Reports Server (NTRS)

    Chen, Dakai; Phan, Anthony; Kim, Hak; Swonger, James; Musil, Paul; LaBel, Kenneth

    2013-01-01

    We show examples of single event functional interrupt and destructive failure in modern POL devices. The increasing complexity and diversity of the design and process introduce hard SEE modes that are triggered by various mechanisms.

  5. How do Interruptions Impact Nurses’ Visual Scanning Patterns When Using Barcode Medication Administration Systems?

    PubMed Central

    He, Ze; Marquard, Jenna L.; Henneman, Philip L.

    2014-01-01

    While barcode medication administration (BCMA) systems have the potential to reduce medication errors, they may introduce errors, side effects, and hazards into the medication administration process. Studies of BCMA systems should therefore consider the interrelated nature of health information technology (IT) use and sociotechnical systems. We aimed to understand how the introduction of interruptions into the BCMA process impacts nurses’ visual scanning patterns, a proxy for one component of cognitive processing. We used an eye tracker to record nurses’ visual scanning patterns while administering a medication using BCMA. Nurses either performed the BCMA process in a controlled setting with no interruptions (n=25) or in a real clinical setting with interruptions (n=21). By comparing the visual scanning patterns between the two groups, we found that nurses in the interruptive environment identified less task-related information in a given period of time, and engaged in more information searching than information processing. PMID:25954449

  6. [Interruption of the aortic arch with no patent ductus arteriosus: is survival possible?].

    PubMed

    Boukhris, M; Hakim, K; Ouarda, F; M'saad, H; Boussaada, R

    2014-03-01

    Interruption of the aortic arch is a rare congenital disease. It is defined by the complete interruption between the ascending and descending aorta. A patent ductus arteriosus is necessary to maintain flow from the pulmonary to the descending aorta. Its closure leads to a cardiovascular collapse and this malformation is therefore duct-dependent. However, in rare cases, survival remains possible even after ductus arteriosus closure. We report such a case. PMID:24457106

  7. Prognostic factors of long-term CD4+count-guided interruption of antiretroviral treatment.

    PubMed

    Sarmati, L; Andreoni, C; Nicastri, E; Tommasi, C; Buonomini, A; D'Ettorre, G; Corpolongo, A; Dori, L; Montano, M; Volpi, A; Narciso, P; Vullo, V; Andreoni, M

    2009-03-01

    Aim of the study was to determine predictors of the duration of antiretroviral treatment interruption in patients infected with HIV. This pilot prospective, open-label, multicenter trial comprised 62 HIV-seropositive subjects who decided voluntarily to interrupt therapy after two or more years of successful HAART. The primary end-point was the time to patients being free of therapy before reaching a CD4+ cell count < or =350/microl. Fifteen of 62 patients remained in treatment interruption for more than 180 days. Patients restarting therapy had higher HIV-DNA levels (P = 0.05), were treated more frequently with NNRTI-drugs (P = 0.02), had a shorter period of HAART (P = 0.046), and lower CD4+ cell counts after day 14 of interruption of treatment (P = 0.04). Multivariate regression analysis showed that less than 323 baseline proviral HIV-DNA cp/10(6) PBMCs and more than 564 CD4 cells/microl at day 14 after interruption were associated independently with a reduced risk of restarting treatment (P = 0.041 and P = 0.012, respectively). A score based on CD4+ cell counts at nadir, at baseline, at week 2 of treatment interruption, and on baseline HIV-DNA values can identify patients with a prolonged period free safely of treatment. PMID:19152399

  8. Apparatus for and method of testing an electrical ground fault circuit interrupt device

    DOEpatents

    Andrews, Lowell B.

    1998-01-01

    An apparatus for testing a ground fault circuit interrupt device includes a processor, an input device connected to the processor for receiving input from an operator, a storage media connected to the processor for storing test data, an output device connected to the processor for outputting information corresponding to the test data to the operator, and a calibrated variable load circuit connected between the processor and the ground fault circuit interrupt device. The ground fault circuit interrupt device is configured to trip a corresponding circuit breaker. The processor is configured to receive signals from the calibrated variable load circuit and to process the signals to determine a trip threshold current and/or a trip time. A method of testing the ground fault circuit interrupt device includes a first step of providing an identification for the ground fault circuit interrupt device. Test data is then recorded in accordance with the identification. By comparing test data from an initial test with test data from a subsequent test, a trend of performance for the ground fault circuit interrupt device is determined.

  9. Apparatus for and method of testing an electrical ground fault circuit interrupt device

    DOEpatents

    Andrews, L.B.

    1998-08-18

    An apparatus for testing a ground fault circuit interrupt device includes a processor, an input device connected to the processor for receiving input from an operator, a storage media connected to the processor for storing test data, an output device connected to the processor for outputting information corresponding to the test data to the operator, and a calibrated variable load circuit connected between the processor and the ground fault circuit interrupt device. The ground fault circuit interrupt device is configured to trip a corresponding circuit breaker. The processor is configured to receive signals from the calibrated variable load circuit and to process the signals to determine a trip threshold current and/or a trip time. A method of testing the ground fault circuit interrupt device includes a first step of providing an identification for the ground fault circuit interrupt device. Test data is then recorded in accordance with the identification. By comparing test data from an initial test with test data from a subsequent test, a trend of performance for the ground fault circuit interrupt device is determined. 17 figs.

  10. Differential effects of traffic sign stimuli upon speeding in school zones following a traffic light interruption.

    PubMed

    Gregory, Bree; Irwin, Julia D; Faulks, Ian J; Chekaluk, Eugene

    2016-01-01

    Motorists whose journey has been interrupted by signalized traffic intersections in school zones resume their journey at a faster vehicle speed than motorists who have not been required to stop. Introducing a flashing "check speed" sign 70m after the traffic intersections counteracts this interruptive effect. The present study examined which aspects of a reminder sign are responsible for reducing the speeding behavior of interrupted motorists. When a sign that combines both written text and flashing lights was introduced, interrupted motorists did not speed, traveling on average 0.82km/h below the 40km/h speed limit when measured 100m from traffic intersections. Alternatively, when only the flashing lights were visible the interrupted motorists sped 3.36km/h over the 40km/h speed limit. Similar vehicular speeds were observed when only the written text was visible and when no sign was present (7.67 and 7.49km/h over the 40km/h speed limit, respectively). This indicates that static reminder signs add little value over the absence of a school zone reminder sign; the presence of both cues is necessary to fully offset the interruptive effect. This study also highlights the benefit of using exogenous visual cues in traffic signs to capture drivers' attention. These findings have practical implications for the design and use of traffic signs to increase compliance with posted speed limits. PMID:26545011

  11. Errors and electronic prescribing: a controlled laboratory study to examine task complexity and interruption effects

    PubMed Central

    Li, Simon Y W; Day, Richard O; Coiera, Enrico

    2010-01-01

    Objective To examine the effect of interruptions and task complexity on error rates when prescribing with computerized provider order entry (CPOE) systems, and to categorize the types of prescribing errors. Design Two within-subject factors: task complexity (complex vs simple) and interruption (interruption vs no interruption). Thirty-two hospital doctors used a CPOE system in a computer laboratory to complete four prescribing tasks, half of which were interrupted using a counterbalanced design. Measurements Types of prescribing errors, error rate, resumption lag, and task completion time. Results Errors in creating and updating electronic medication charts that were measured included failure to enter allergy information; selection of incorrect medication, dose, route, formulation, or frequency of administration from lists and drop-down menus presented by the CPOE system; incorrect entry or omission in entering administration times, start date, and free-text qualifiers; and omissions in prescribing and ceasing medications. When errors occurred, the error rates across the four prescribing tasks ranged from 0.5% (1 incorrect medication selected out of 192 chances for selecting a medication or error opportunities) to 16% (5 failures to enter allergy information out of 32 error opportunities). Any impact of interruptions on prescribing error rates and task completion times was not detected in our experiment. However, complex tasks took significantly longer to complete (F(1, 27)=137.9; p<0.001) and when execution was interrupted they required almost three times longer to resume compared to simple tasks (resumption lag complex=9.6 seconds, SD=5.6; resumption lag simple=3.4 seconds, SD=1.7; t(28)=6.186; p<0.001). Conclusion Most electronic prescribing errors found in this study could be described as slips in using the CPOE system to create and update electronic medication charts. Cues available within the user interface may have aided resumption of interrupted tasks

  12. Effect of Radiotherapy Interruptions on Survival in Medicare Enrollees With Local and Regional Head-and-Neck Cancer

    SciTech Connect

    Fesinmeyer, Megan Dann; Mehta, Vivek; Blough, David; Tock, Lauri; Ramsey, Scott D.

    2010-11-01

    Purpose: To investigate whether interruptions in radiotherapy are associated with decreased survival in a population-based sample of head-and-neck cancer patients. Methods and Materials: Using the Surveillance, Epidemiology, and End Results-Medicare linked database we identified Medicare beneficiaries aged 66 years and older diagnosed with local-regional head-and-neck cancer during the period 1997-2003. We examined claims records of 3864 patients completing radiotherapy for the presence of one or more 5-30-day interruption(s) in therapy. We then performed Cox regression analyses to estimate the association between therapy interruptions and survival. Results: Patients with laryngeal tumors who experienced an interruption in radiotherapy had a 68% (95% confidence interval, 41-200%) increased risk of death, compared with patients with no interruptions. Patients with nasal cavity, nasopharynx, oral, salivary gland, and sinus tumors had similar associations between interruptions and increased risk of death, but these did not reach statistical significance because of small sample sizes. Conclusions: Treatment interruptions seem to influence survival time among patients with laryngeal tumors completing a full course of radiotherapy. At all head-and-neck sites, the association between interruptions and survival is sensitive to confounding by stage and other treatments. Further research is needed to develop methods to identify patients most susceptible to interruption-induced mortality.

  13. An evaluation of interrupted and uninterrupted measurement of vocal stereotypy on perceived treatment outcomes.

    PubMed

    Carroll, Regina A; Kodak, Tiffany

    2014-01-01

    The type of procedure used to measure a target behavior may directly influence the perceived treatment outcomes. In the present study, we examined the influence of different data-analysis procedures on the outcomes of two commonly used treatments on the vocal stereotypy of 2 children with an autism spectrum disorder. In Study 1, we compared an interrupted and uninterrupted data-analysis procedure to measure vocal stereotypy during the implementation of response interruption and redirection (RIRD). The results showed that the interrupted data-analysis procedure overestimated the effectiveness of RIRD. In Study 2, we examined the influence of different data-analysis procedures on the interpretation of the relative effects of 2 different treatments for vocal stereotypy. Specifically, we compared interrupted and uninterrupted data-analysis procedures during the implementation of RIRD and noncontingent reinforcement (NCR) as a treatment for vocal stereotypy. The results showed that, as in Study 1, the interrupted data-analysis procedure overestimated the effectiveness of RIRD; however, this effect was not apparent with NCR. These findings suggest that different types of data analysis can influence the perceived success of a treatment. PMID:24764249

  14. Supervisory-level interruption recovery in time-critical control tasks.

    PubMed

    Sasangohar, Farzan; Scott, Stacey D; Cummings, M L

    2014-07-01

    This paper investigates the effectiveness of providing interruption recovery assistance in the form of an interactive visual timeline of historical events on a peripheral display in support of team supervision in time-critical settings. As interruptions can have detrimental effects on task performance, particularly in time-critical work environments, there is growing interest in the design of tools to assist people in resuming their pre-interruption activity. A user study was conducted to evaluate the use of an interactive event timeline that provides assistance to human supervisors in time-critical settings. The study was conducted in an experimental platform that emulated a team of operators and a mission commander performing a time-critical unmanned aerial vehicle (UAV) mission. The study results showed that providing interruption assistance enabled people to recover from interruptions faster and more accurately. These results have implications for interface design that could be adopted in similar time-critical environments such as air-traffic control, process control, and first responders. PMID:24581931

  15. Workflow interruptions, social stressors from supervisor(s) and attention failure in surgery personnel

    PubMed Central

    PEREIRA, Diana; MÜLLER, Patrick; ELFERING, Achim

    2015-01-01

    Workflow interruptions and social stressors among surgery personnel may cause attention failure at work that may increase rumination about work issues during leisure time. The test of these assumptions should contribute to the understanding of exhaustion in surgery personnel and patient safety. Workflow interruptions and supervisor-related social stressors were tested to predict attention failure that predicts work-related rumination during leisure time. One hundred ninety-four theatre nurses, anaesthetists and surgeons from a Swiss University hospital participated in a cross-sectional survey. The participation rate was 58%. Structural equation modelling confirmed both indirect paths from workflow interruptions and social stressors via attention failure on rumination (both p<0.05). An alternative model, assuming the reversed indirect causation—from attention failure via workflow interruptions and social stressors on rumination—could not be empirically supported. Workflow interruptions and social stressors at work are likely to trigger attention failure in surgery personnel. Work redesign and team intervention could help surgery personnel to maintain a high level of quality and patient safety and detach from work related issues to recover during leisure time. PMID:26027706

  16. [Complete repair of the interrupted aortic arch by an anterior approach. Apropos of 9 cases].

    PubMed

    Chambran, P; Planché, C; Bruniaux, J; Lacour-Gayet, F; Binet, J P

    1988-05-01

    Interrupted aortic arch is a duct-dependent heart disease, and this is why the use of prostaglandins E, which keep the ductus arteriosus open to feed the descending aorta, has transformed its formerly sombre prognosis. The authors report the cases of 9 neonates and infants presenting with interrupted aortic arch associated with ventricular septal defect who underwent total repair of the malformations under extracorporeal circulation. Five children were less than 10 years' old. The aortic lesions were of type A in 2 cases (interruption distal to the left subclavian artery) and of type B in 7 cases (interruption between the left carotid and subclavian arteries). In the second group the lesions were of type B1 in 5 cases (without retro-oesophageal right subclavian artery) and of type B2 in 2 cases (right retro-oesophageal artery distal to the interruption). There was one death (11 p. 100). So far, no child has been reoperated upon for residual aortic obstruction or reopened ventricular septal defect. This technique of total repair in one stage, with closure of the ventricular septal defect, seems to be preferable to the two-stage technique in which stage one includes, in addition to aortic arch repair, cerclage of the pulmonary artery, a procedure with numerous disadvantages and a higher overall mortality rate. PMID:3136722

  17. Photodiode-based cutting interruption sensor for near-infrared lasers.

    PubMed

    Adelmann, B; Schleier, M; Neumeier, B; Hellmann, R

    2016-03-01

    We report on a photodiode-based sensor system to detect cutting interruptions during laser cutting with a fiber laser. An InGaAs diode records the thermal radiation from the process zone with a ring mirror and optical filter arrangement mounted between a collimation unit and a cutting head. The photodiode current is digitalized with a sample rate of 20 kHz and filtered with a Chebyshev Type I filter. From the measured signal during the piercing, a threshold value is calculated. When the diode signal exceeds this threshold during cutting, a cutting interruption is indicated. This method is applied to sensor signals from cutting mild steel, stainless steel, and aluminum, as well as different material thicknesses and also laser flame cutting, showing the possibility to detect cutting interruptions in a broad variety of applications. In a series of 83 incomplete cuts, every cutting interruption is successfully detected (alpha error of 0%), while no cutting interruption is reported in 266 complete cuts (beta error of 0%). With this remarkable high detection rate and low error rate, the possibility to work with different materials and thicknesses in combination with the easy mounting of the sensor unit also to existing cutting machines highlight the enormous potential for this sensor system in industrial applications. PMID:26974642

  18. Knowing before doing: discrimination by rats of a brief interruption of a tone.

    PubMed Central

    Eisler, H

    1984-01-01

    Eight rats' lever presses were reinforced after an interruption in a tone, provided the lever had not been pressed before the tone interruption. After a few sessions, long before the animals reliably refrained from lever pressing before the interruption, the latencies of postinterruption presses (time from the termination of the interruption to the moment of the lever press) dissociated into two classes: short ones for to-be-rewarded presses, and long ones for presses in the other trials, which contained no reward because one or more lever presses had occurred before the interruption. Thus discrimination of impending reinforcement in the current trial occurred before there was evidence of sensitivity to reinforcement in the reinforcement-producing aspect of behavior. This finding is related to Shimp's (1981) contention that the temporal properties of recent behavior are reinforceable, if remembered. The present finding shows that learning to discriminate whether one's behavior has met a contingency, and learning to carry out this behavior, need not go together, implying that memory of temporal properties is probably a necessary but not a sufficient condition for learning the latter. PMID:6736860

  19. Viral re-suppression and detection of drug resistance following interruption of a suppressive NNRTI-based regimen

    PubMed Central

    Fox, Zoe; Phillips, Andrew; Cohen, Cal; Neuhaus, Jacquie; Baxter, John; Emery, Sean; Hirschel, Bernard; Hullsiek, Kathy Huppler; Stephan, Christoph; Lundgren, Jens

    2009-01-01

    Background Interruption of an NNRTI-regimen is often necessary, but must be performed with caution because NNRTIs have a low genetic barrier to resistance. Limited data exist to guide clinical practice on the best interruption strategy to use. Methods Patients in the drug-conservation arm of SMART who interrupted a fully suppressive NNRTI-regimen were evaluated. From 2003, SMART recommended interruption of an NNRTI by: a staggered-interruption, where the NNRTI was stopped before the NRTIs; or by replacing the NNRTI with another drug before interruption. Simultaneous-interruption of all ARVs was discouraged. Re-suppression rates four-to-eight months after re-initiating NNRTI-therapy were assessed, as was the detection of drug-resistance mutations within two months of the treatment interruption in a subset (N=141). Results Overall, 601/688 (87.4%) patients who re-started an NNRTI achieved viral re-suppression. The adjusted odds ratio (95% CI) for achieving re-suppression was 1.94 (1.02-3.69) for patients with a staggered-interruption and 3.64 (1.37-9.64) for those with a switched-interruption compared to patients with a simultaneous-interruption. At least one NNRTI-mutation was detected in the virus of 16.4% patients with simultaneous-interruption, 12.5% patients with staggered-interruption and 4.2% patients with switched-interruption. Fewer patients with detectable mutations (i.e. 69.2%) achieved HIV-RNA≤400 copies/mL compared to those in whom no mutations were detected (i.e. 86.7%), p=0.05. Conclusions In patients who interrupt a suppressive NNRTI-regimen, the choice of interruption-strategy may influence re-suppression rates when re-starting a similar regimen. NNRTI drug-resistance mutations were observed in a relatively high proportion of patients. These data provide additional support for a staggered- or switched-interruption strategy for NNRTI drugs. PMID:18981767

  20. Current interruption limit and resistance of the self-similar electric arc

    NASA Astrophysics Data System (ADS)

    Christen, Thomas; Seeger, Martin

    2005-05-01

    A model for the axially blown cylindrical arc is derived. In contrast to earlier theories, the model is gauge invariant with respect to energy, which is crucial for investigating current interruption. We determine from our model the dependence of the maximum interruptible current rate, (dI/dt)L, on the pressure, on the parallel capacitance, and on the line impedance for an SF6 arc. (dI/dt)L scales, approximately independent of the gas type, with the square root of the pressure. The arc resistance, at current zero with current rate equal to (dI/dt)L, is pressure independent. As a consequence, the arc resistance at current zero can serve as a figure of merit for the interruption performance of gas circuit breakers.

  1. Electric circuit breaker comprising a plurality of vacuum interrupters simultaneously operated by a common operator

    DOEpatents

    Barkan, Philip; Imam, Imdad

    1980-01-01

    This circuit breaker comprises a plurality of a vacuum-type circuit interrupters, each having a movable contact rod. A common operating device for the interrupters comprises a linearly-movable operating member. The interrupters are mounted at one side of the operating member with their movable contact rods extending in a direction generally toward the operating member. Means is provided for mechanically coupling the operating member to the contact rods, and this means comprises a plurality of insulating operating rods, each connected at one end to the operating member and at its opposite end to one of the movable contact rods. The operating rods are of substantially equal length and have longitudinal axes that converge and intersect at substantially a common point.

  2. Effect of Different Vent Configurations on the Interruption Performance of Arc Chamber

    NASA Astrophysics Data System (ADS)

    Chen, Degui; Li, Xingwen; Dai, Ruicheng

    Gas flow in arc quenching chamber has an important effect on the interruption capability of low voltage circuit breakers. In this paper, based on a simplified model of arc chamber with a single break, which can be opened by the electro-dynamics repulsion force automatically, the effect of different vent configurations including middle vent and side vent on the interruption performance is investigated. First, the experiments are carried out to compare the different performance in the interruption process between middle vent type and side vent type. In addition, according to the experimental model, a 3-D magneto-hydrodynamic model was developed by adapting and modified the commercial computational fluid dynamics software FLUENT. The simulation results show the same trend in arc motion as explained in the experimental conclusions in theory.

  3. Growth-interruption-induced low-density InAs quantum dots on GaAs

    SciTech Connect

    Li, L. H.; Alloing, B.; Chauvin, N.; Fiore, A.; Patriarche, G.

    2008-10-15

    We investigate the use of growth interruption to obtain low-density InAs quantum dots (QDs) on GaAs. The process was realized by Ostwald-type ripening of a thin InAs layer. It was found that the optical properties of the QDs as a function of growth interruption strongly depend on InAs growth rate. By using this approach, a low density of QDs (4 dots/{mu}m{sup 2}) with uniform size distribution was achieved. As compared to QDs grown without growth interruption, a larger energy separation between the QD confined levels was observed, suggesting a situation closer to the ideal zero-dimensional system. Combining with an InGaAs capping layer such as In-rich QDs enable 1.3 {mu}m emission at 4 K.

  4. Operation Method for AC Motor Control during Power Interruption in Direct AC/AC Converter System

    NASA Astrophysics Data System (ADS)

    Shizu, Keiichiro; Azuma, Satoshi

    Direct AC/AC converters have been studied due to their potential use in power converters with no DC-link capacitor, which can contribute to the miniaturization of power converters. However, the absence of a DC-link capacitor makes it difficult to control the AC motor during power interruption. First, this paper proposes a system that realizes AC motor control during power interruption by utilizing a clamp capacitor. In general, direct AC/AC converters have a clamp circuit consisting of a rectifier diode(s) and a clamp capacitor in order to avoid over-voltages. In the proposed system, there is an additional semiconductor switch reverse-parallel to the rectifier diode(s), and the clamp capacitor voltage can be utilized for AC motor control by turning on the additional switch. Second, this paper discusses an operation method for AC motor control and clamp capacitor voltage control during power interruption. In the proposed method “DC-link voltage control”, the kinetic energy in the AC motor is transformed into electrical energy and stored in the clamp capacitor; the clamp capacitor is therefore charged and the capacitor voltage is controlled to remain constant at an instruction value. Third, this paper discusses a switching operation during power interruption. A dead-time is introduced between the operation of turning off all switches on the rectifier side and the operation of turning on the additional switch, which prevents the occurrence of a short circuit between the interrupted power source and the clamp capacitor. Finally, experimental results are presented. During power interruptions, an output current was continuously obtained and the clamp capacitor voltage was maintained to be equal to the instruction value of the capacitor voltage. These results indicate that both AC motor control and capacitor voltage control were successfully achieved by using the proposed system.

  5. Investigation on X-Radiation for 126 kV Vacuum Interrupters

    NASA Astrophysics Data System (ADS)

    Yan, Jing; Liu, Zhiyuan; Geng, Yingsan; Zhang, Sheng; Zhang, Yingyao

    2016-05-01

    When subjected to high voltages between opened contacts, vacuum interrupters may emit X-rays. In order to ensure that these are of an acceptable level, vacuum interrupters should comply with the limits for X-ray emission and the test procedures to be carried out to verify this based on relevant standards and specifications. In this paper, a comprehensive experimental study has been performed for 126 kV vacuum interrupters used in a transmission system to understand the X-radiation level and its influence by three main parameters, namely applied power-frequency voltage, contact gap and power-frequency voltage conditioning. The radiation instrument is an FJ347 radiometer and the X-radiation dose was measured at the power-frequency test voltage. These tests demonstrated that the X-radiation emission level for a 126 kV vacuum interrupter did not exceed the following: 5 μSv per hour at a rated voltage of 126 kV and 150 μSv per hour at a power-frequency voltage of 230 kV at 1 m distance. The X-radiation dose increased with the applied power-frequency voltage increasing and decreased with the contact gap increasing. The X-radiation dose for 126 kV vacuum interrupters decreased by 57% after the conditioning procedure with a certain power-frequency voltage. During the conditioning procedure, the average value of the X-radiation dose was 4.49 mSv, which means if a professional conditions 180 interrupters per year, it will be safe at the 6.4 m distance. supported by National Key Basic Research Program of China (973 Program) (No. 2015CB251002)

  6. Interruptions and resistance: a comparison of medical consultations with family and trained interpreters.

    PubMed

    Leanza, Yvan; Boivin, Isabelle; Rosenberg, Ellen

    2010-06-01

    While working with trained interpreters in health care is strongly recommended, few studies have looked at the subtle differences in communication processes between trained and "ad hoc" interpreters, such as adult family members. Using Habermas' Communicative Action Theory (CAT) which distinguishes between the Lifeworld (contextually grounded experiences) and the System (decontextualized rules), we analysed 16 family practice consultations with interpreters, 10 with a trained interpreter and 6 with a family member. We found clear differences in communication patterns between consultations with a trained interpreter and consultations with a family member as interpreter. In both cases the Lifeworld is frequently interrupted and the outcomes are similar: the Lifeworld is rarely heard and acknowledged by the physician. Physicians interrupt the Voice of the Lifeworld significantly more with a trained interpreter than with a family member. Family members and trained interpreters also interrupt the Voice of the Lifeworld just as much. However, these interruptions differ in their functions (both physicians and interpreters interrupt to keep the interview on track to meet the biomedical goals; family interpreters interrupt to control the agenda). We have identified patients' resistance when physicians ignore their Lifeworld, but this resistance is usually only transmitted by professional interpreters (and not by family interpreters). We identified specific risks of working with family interpreters: imposing their own agenda (vs. the patient's one) and controlling the consultation process. Even if the collaboration with trained interpreters becomes more widespread, work with "ad hoc" interpreters will continue to occur. Therefore, institutions should provide training and organizational support to help physicians and patients to achieve communication in all situations. PMID:20378224

  7. Hybrid intervention for type A aortic arch interruption and a giant subclavian artery aneurysm in an adult.

    PubMed

    Oz, Kursad; Erek, Ersin; Yildirim, Aydin

    2016-06-01

    Interrupted aortic arch is a very rare but well-described congenital anomaly. Concomitant presentation of interrupted aortic arch and giant subclavian artery aneurysm is an unusual event in adulthood. To the best of our knowledge, hybrid intervention for type A aortic arch interruption with a giant aneurysm of the subclavian artery is an alternative approach for the management of these concomitant pathologies in adults. PMID:27071339

  8. The effect of a safe zone on nurse interruptions, distractions, and medication administration errors.

    PubMed

    Yoder, Mindy; Schadewald, Diane; Dietrich, Kim

    2015-01-01

    Patient safety is a health care priority. Yet medical errors are ranked the eighth leading cause of death. Medication administration errors (MAEs) often result from multiple environmental and individual factors. This quality improvement initiative adapted a protocol based on airline industry safety measures to decrease nurse distractions and interruptions during medication administration, with the goal of decreasing MAEs. Sources of distractions, interruptions, and MAEs were measured pre and post intervention. Patient satisfaction scores were measured concurrently. Results of this initiative differ from previous studies in which similar interventions reduced both distractions and MAEs. An unexpected finding was dramatically increased patient satisfaction. PMID:25723837

  9. The effect of interrupted alcohol supply on spontaneous alcohol consumption by rhesus monkeys.

    PubMed

    Kornet, M; Goosen, C; Van Ree, J M

    1990-01-01

    The alcohol supply (a 16% and a 32%, v/v, ethanol-in-water solution) for eight male rhesus monkeys, who already have had free access to water and ethanol solutions concurrently for about one year, was interrupted for 1, 2 or 7 days. The previously acquired ethanol consuming behaviour appeared very resistant to extinction, because ethanol consumption was immediately resumed after renewed access, even at a temporarily increased level. Since physical withdrawal distress was not observed and the increase was higher when interruption lasted longer, the observed behaviour could be attributed to the reinforcing effects of ethanol, leading to specific ethanol-directed behaviour. PMID:2222574

  10. Interruption in the maintenance of compulsive sexual disorder: two case studies.

    PubMed

    Konopacki, W P; Oei, T P

    1988-10-01

    Sexual offenses and disorders are at times compulsive in nature. It is hypothesized that compulsive sexuality is a function of a history of interrupted or frustrated approach behavior. Two case studies involving compulsive features were treated by preventing such interruptions and delays. An A-B-A-B single-case experimental design on one of the two case studies provided some support for the hypothesized relationship. Implications for assessment and treatment are examined and the mechanisms underlying the hypothesized relationship are discussed. PMID:3219064

  11. Influence of the traffic interruption probability on traffic stability in lattice model for two-lane freeway

    NASA Astrophysics Data System (ADS)

    Peng, Guanghan; Liu, Changqing; Tuo, Manxian

    2015-10-01

    In this paper, a new lattice model is proposed with the traffic interruption probability term in two-lane traffic system. The linear stability condition and the mKdV equation are derived from linear stability analysis and nonlinear analysis by introducing the traffic interruption probability of optimal current for two-lane traffic freeway, respectively. Numerical simulation shows that the traffic interruption probability corresponding to high reaction coefficient can efficiently improve the stability of two-lane traffic flow as traffic interruption occurs with lane changing.

  12. Microwave Induced Enhancement of the Subgap Josephson dc Current

    NASA Astrophysics Data System (ADS)

    Lundin, N. I.; Shekhter, R. I.; Jonson, M.; Gorelik, L. Y.; Shumeiko, V. S.

    1998-03-01

    We introduce a mechanism for lifting the suppression of the subgap dc-Josephson current in a ballistic, normal, one-dimensional quantum channel between two superconducting electrodes with moderate amount of backscattering. The current appears when a non-equilibrium population of the Andreev levels carrying the current, is developed due to photon-induced Landua-Zener transitions.

  13. Mitigating Disruptive Effects of Interruptions through Training: What Needs to Be Practiced?

    ERIC Educational Resources Information Center

    Cades, David M.; Boehm-Davis, Deborah A.; Trafton, J. Gregory; Monk, Christopher A.

    2011-01-01

    It is generally accepted that, with practice, people improve on most tasks. However, when tasks have multiple parts, it is not always clear what aspects of the tasks practice or training should focus on. This research explores the features that allow training to improve the ability to resume a task after an interruption, specifically focusing on…

  14. Acoustic Predictors of Intelligibility for Segmentally Interrupted Speech: Temporal Envelope, Voicing, and Duration

    ERIC Educational Resources Information Center

    Fogerty, Daniel

    2013-01-01

    Purpose: Temporal interruption limits the perception of speech to isolated temporal glimpses. An analysis was conducted to determine the acoustic parameter that best predicts speech recognition from temporal fragments that preserve different types of speech information--namely, consonants and vowels. Method: Young listeners with normal hearing…

  15. Rapid Resumption of Interrupted Search Is Independent of Age-Related Improvements in Visual Search

    ERIC Educational Resources Information Center

    Lleras, Alejandro; Porporino, Mafalda; Burack, Jacob A.; Enns, James T.

    2011-01-01

    In this study, 7-19-year-olds performed an interrupted visual search task in two experiments. Our question was whether the tendency to respond within 500 ms after a second glimpse of a display (the "rapid resumption" effect ["Psychological Science", 16 (2005) 684-688]) would increase with age in the same way as overall search efficiency. The…

  16. Interrupted Experiences: Reflection, Listening and "Negativity" in the Practice of Teaching

    ERIC Educational Resources Information Center

    English, Andrea

    2007-01-01

    This inquiry explores the educative meaning of interruptions or breaks in teacher's experiences by looking at their role in reflection and listening. Reflection and listening are not only two vital and distinct aspects of teaching, but are also interrelated and as such can serve to productively inform one another. In this context, I develop the…

  17. RTtxGap: An android radiobiological tool for compensation of radiotherapy treatment interruption

    NASA Astrophysics Data System (ADS)

    Yusoff, A. L.; Mohamad, M.; Abdullah, R.; Bhavaraju, V. M. K.; Nik Idris, N. R.

    2016-03-01

    Treatment interruption is not uncommon in radiotherapy. Common reasons for treatment interruption include machine breakdown, holidays and patient severe radiation reactions. Here RTtxGap, an Android application to assist calculations of compensation for treatment gap, is reported. It uses linear quadratic (LQ) model to calculate the biological effective dose (BED) that is used to solve for treatment gap compensations. Solutions are calculated using BED equation, with consideration for tissue proliferation. The accuracy of results has been verified using LQL Equiv software to be accurate within 1%. Five treatment interruption examples were used to illustrate the capability of the software to calculate the treatment compensation schedules. Solving these examples also illustrates the general consensus regarding compensating for unscheduled treatment interruptions, which ultimately involves balancing the BEDs of tumour and organ at risk. In addition to compensation for treatment gap, RTtxGap can also be used to calculate equivalent total dose in 2-Gy fraction (EQD2), to modify treatment schedule and to calculate alternative dose prescriptions having the same isoeffect.

  18. Assigning Student Leaders: Decreasing Interruptions during Teacher-Led Small-Group Instruction

    ERIC Educational Resources Information Center

    Coles, Jeremy T.; Skinner, Christopher H.; Best, Tiffany L.; Wood, Allison; Luna, Elisa; Adcock, Wes

    2013-01-01

    The authors used a withdrawal design to evaluate an intervention designed to decrease interruptions during small-group instruction in a Kindergarten class. A new rule was put into place; during teacher-led small-group instruction, those not in the small group were required to address questions to designated student leaders, as opposed to…

  19. Recognition of temporally interrupted and spectrally degraded sentences with additional unprocessed low-frequency speech

    PubMed Central

    Başkent, Deniz; Chatterjee, Monita

    2010-01-01

    Recognition of periodically interrupted sentences (with an interruption rate of 1.5 Hz, 50% duty cycle) was investigated under conditions of spectral degradation, implemented with a noiseband vocoder, with and without additional unprocessed low-pass filtered speech (cutoff frequency 500 Hz). Intelligibility of interrupted speech decreased with increasing spectral degradation. For all spectral-degradation conditions, however, adding the unprocessed low-pass filtered speech enhanced the intelligibility. The improvement at 4 and 8 channels was higher than the improvement at 16 and 32 channels: 19% and 8%, on average, respectively. The Articulation Index predicted an improvement of 0.09, in a scale from 0 to 1. Thus, the improvement at poorest spectral-degradation conditions was larger than what would be expected from additional speech information. Therefore, the results implied that the fine temporal cues from the unprocessed low-frequency speech, such as the additional voice pitch cues, helped perceptual integration of temporally interrupted and spectrally degraded speech, especially when the spectral degradations were severe. Considering the vocoder processing as a cochlear-implant simulation, where implant users’ performance is closest to 4 and 8-channel vocoder performance, the results support additional benefit of low-frequency acoustic input in combined electric-acoustic stimulation for perception of temporally degraded speech. PMID:20817081

  20. Evaluation of the Immediate and Subsequent Effects of Response Interruption and Redirection on Vocal Stereotypy

    ERIC Educational Resources Information Center

    Schumacher, Brittany I.; Rapp, John T.

    2011-01-01

    We evaluated 2 3-component multiple-schedule sequences--a response interruption and redirection (RIRD) treatment sequence and a no-interaction control sequence--using a multielement design. With this design, we were able to evaluate the immediate and subsequent effects of RIRD on 2 participants' vocal stereotypy. For both participants, RIRD…

  1. Relational Identity Making on the Professional Landscape as a Substitute Teacher: Interruptions and Continuities

    ERIC Educational Resources Information Center

    Driedger-Enns, Lynnette M.

    2014-01-01

    This article, which comes out of a research project exploring teaching as intellectual work, focuses specifically on a young woman who worked as a substitute teacher after she graduated from a two-year teacher education program at her local university. For Penny, substitute teaching was an interruption as she shaped a professional life moving…

  2. Using Exponential Smoothing to Specify Intervention Models for Interrupted Time Series.

    ERIC Educational Resources Information Center

    Mandell, Marvin B.; Bretschneider, Stuart I.

    1984-01-01

    The authors demonstrate how exponential smoothing can play a role in the identification of the intervention component of an interrupted time-series design model that is analogous to the role that the sample autocorrelation and partial autocorrelation functions serve in the identification of the noise portion of such a model. (Author/BW)

  3. A Unified Framework for Estimating Minimum Detectable Effects for Comparative Short Interrupted Time Series Designs

    ERIC Educational Resources Information Center

    Price, Cristofer; Unlu, Fatih

    2014-01-01

    The Comparative Short Interrupted Time Series (C-SITS) design is a frequently employed quasi-experimental method, in which the pre- and post-intervention changes observed in the outcome levels of a treatment group is compared with those of a comparison group where the difference between the former and the latter is attributed to the treatment. The…

  4. A Comparison of Alternative Approaches to the Analysis of Interrupted Time-Series.

    ERIC Educational Resources Information Center

    Harrop, John W.; Velicer, Wayne F.

    1985-01-01

    Computer generated data representative of 16 Auto Regressive Integrated Moving Averages (ARIMA) models were used to compare the results of interrupted time-series analysis using: (1) the known model identification, (2) an assumed (l,0,0) model, and (3) an assumed (3,0,0) model as an approximation to the General Transformation approach. (Author/BW)

  5. Comparison Groups in Short Interrupted Time-Series: An Illustration Evaluating No Child Left Behind

    ERIC Educational Resources Information Center

    Wong, Manyee; Cook, Thomas D.; Steiner, Peter M.

    2009-01-01

    Interrupted time-series (ITS) are often used to assess the causal effect of a planned or even unplanned shock introduced into an on-going process. The pre-intervention slope is supposed to index the causal counterfactual, and deviations from it in mean, slope or variance are used to indicate an effect. However, a secure causal inference is only…

  6. Further Evaluation of Response Interruption and Redirection as Treatment for Stereotypy

    ERIC Educational Resources Information Center

    Ahrens, Erin N.; Lerman, Dorothea C.; Kodak, Tiffany; Worsdell, April S.; Keegan, Courtney

    2011-01-01

    The effects of 2 forms of response interruption and redirection (RIRD)--motor RIRD and vocal RIRD--were examined with 4 boys with autism to evaluate further the effects of this intervention and its potential underlying mechanisms. In Experiment 1, the effects of motor RIRD and vocal RIRD on vocal stereotypy and appropriate vocalizations were…

  7. Response Interruption and Redirection for Vocal Stereotypy in Children with Autism: A Systematic Replication

    ERIC Educational Resources Information Center

    Cassella, Megan Duffy; Sidener, Tina M.; Sidener, David W.; Progar, Patrick R.

    2011-01-01

    This study systematically replicated and extended previous research on response interruption and redirection (RIRD) by assessing instructed responses of a different topography than the target behavior, percentage of session spent in treatment, generalization of behavior reduction, and social validity of the intervention. Results showed that RIRD…

  8. The Effects of Response Interruption and Redirection and Sertraline on Vocal Stereotypy

    ERIC Educational Resources Information Center

    Miguel, Caio F.; Clark, Kathy; Tereshko, Lisa; Ahearn, William H.

    2009-01-01

    Although response interruption and redirection (RIRD) has been shown to be successful in reducing vocal stereotypy, recent reports have suggested that selective serotonin reuptake inhibitors (SSRIs) may also reduce these behaviors. The purpose of the current investigation was to examine the effects of RIRD with and without sertraline on…

  9. Preparing School Leaders to Interrupt Racism at Various Levels in Educational Systems

    ERIC Educational Resources Information Center

    Boske, Christa

    2015-01-01

    This narrative inquiry seeks to advance the field of educational leadership preparation by exploring ways to interrupt personal, interpersonal, and institutional racism through the senses--ways in which people perceive their experiences and relation to others. Findings suggest that participants engage in actions aligned with revelations from their…

  10. Elicitation of sleep-onset REM periods in normal individuals using the sleep interruption technique (SIT).

    PubMed

    Takeuchi, Tomoka; Fukuda, Kazuhiko; Murphy, Timothy I

    2002-11-01

    Use of the sleep interruption technique (SIT) to elicit sleep onset REM periods (SOREMPs) in normal individuals is introduced along with its theoretical bases, empirical findings, and potential applications. Capitalizing upon the circadian and ultradian nature of REM sleep, the SIT has been developed to examine various psychophysiological characteristics related to REM sleep. The SIT allows us to: (1) obtain SOREMPs at the discretion of the researcher; (2) avoid the contaminating effects of preceding non-REM (NREM)-REM stage ordering on subsequent target sleep episodes; and (3) obtain many REM episodes in a short time by repeating the sleep interruptions. The SIT has been applied in several studies, such as examination of physiological precursors to REM periods, correlates of dream mechanisms, and induction of sleep paralysis in normal individuals. Guidelines for eliciting SOREMP using the SIT, including the parameters to be manipulated, are provided, e.g. NREM duration before sleep interruption, time of night of awakenings, duration of sleep interruption and tasks employed. Directions for further research such as determining optimal type of task to promote SOREMP occurrences, generalization of SOREMP as usual REM periods, and forms of SOREMP occurrences under different conditions in normal individuals and clinical patients are discussed. Finally, possible future uses of the SIT, including combining this technique with new technologies, are also suggested. PMID:14592142

  11. Re-Thinking Pedagogy for Middle School Students with Little, No or Severely Interrupted Schooling

    ERIC Educational Resources Information Center

    Dooley, Karen

    2009-01-01

    The arrival of substantial cohorts of English language learners from Africa with little, no or severely interrupted schooling is requiring new pedagogic responses from teachers in Australia and other Western countries of refugee re-settlement. If the students are to have optimal educational and life chances, it is crucial for them to acquire…

  12. Timing for distribution and interrupt control for the TOPAZ Data Acquisition System

    SciTech Connect

    Ikeda, H.; Enomoto, R.; Kawabata, S.; Yamauchi, M.; Imanishi, A.; Ishii, T.; Maruyama, K.; Masuda, H.; Okumo, H.; Ukai, K.

    1987-02-01

    In order to provide a standardized control for the data acquisition system for the TOPAZ detector, a Timing Server/Receiver scheme was developed. The entire system is under control of the Interrupt Control Section, which manages an integral operation of the data acquisition system in the FASTBUS environment.

  13. The Effects of Verbal Operant Training and Response Interruption and Redirection on Appropriate and Inappropriate Vocalizations

    ERIC Educational Resources Information Center

    Colon, Candice L.; Ahearn, William H.; Clark, Kathleen M.; Masalsky, Jessica

    2012-01-01

    Past research has shown that response interruption and redirection (RIRD) can effectively decrease automatically reinforced motor behavior (Hagopian & Adelinis, 2001). Ahearn, Clark, MacDonald, and Chung (2007) found that a procedural adaptation of RIRD reduced vocal stereotypy and increased appropriate vocalizations for some children, although…

  14. Effects of undulator interruptions on the performance of high-gain FEL amplifiers

    SciTech Connect

    Kim, K.J.; Xie, M.; Pelligrini, C.

    1995-12-31

    The high-gain amplifiers for short wavelength free electron lasers (FELs) such as the LCLS project require a long undulator. The construction of the undulator as well as the FEL operation would become easier if the undulator could be interrupted with drift sections every few gain lengths. We have investigated the influence of such interruption on the FEL performances. Three effects are considered: (i) the diffraction loss, (ii) the phase mismatch and, (iii) the phase smearing due to velocity spread and to dispersion errors. The effect (i) is the loss during the process in which the optical mode in a section of the undulator leaves the undulator, propagates through the free space and then re-enters and re-adjusts in the next section. The effect (ii) is the fact that the phase of the optical beam is displaced with respect to the electrons density modulation for optical FEL interaction due to the slippage of the electron beam in the interruption region. The effect (iii) is the fact that electrons velocity spread, emittance, and dispersion due to misalignment of the quadrupoles used for additional focusing lead to a reduction of the bunching factor. We present an approximate analysis of these effects. When applied to the LCLS parameters, we find that the effect (i) is negligible, the effect (ii) gives a condition on the length of the drift section, and the effects (iii) are small, but could be non-negligible if there are sufficient number of interruptions.

  15. Teaching Refugee Learners with Interrupted Education in Science: Vocabulary, Literacy and Pedagogy

    ERIC Educational Resources Information Center

    Miller, Jennifer

    2009-01-01

    With the globalisation of education, large numbers of students with interrupted schooling and low English literacy levels represent both a quantitative and qualitative shift in the kinds of students faced by teachers in classrooms. In Australia, after a year in an intensive English language programme, immigrant and refugee students are placed in…

  16. Immediate and Subsequent Effects of Response Interruption and Redirection on Targeted and Untargeted Forms of Stereotypy

    ERIC Educational Resources Information Center

    Pastrana, Sarah J.; Rapp, John T.; Frewing, Tyla M.

    2013-01-01

    A number of studies have shown that response interruption and redirection (RIRD) decreases immediate engagement in targeted stereotypic behaviors; however, its effects on untargeted stereotypy have not yet been studied, and its effects following removal of treatment are unclear. We evaluated the immediate and subsequent effects of RIRD on targeted…

  17. Improving Memory after Interruption: Exploiting Soft Constraints and Manipulating Information Access Cost

    ERIC Educational Resources Information Center

    Morgan, Phillip L.; Patrick, John; Waldron, Samuel M.; King, Sophia L.; Patrick, Tanya

    2009-01-01

    Forgetting what one was doing prior to interruption is an everyday problem. The recent soft constraints hypothesis (Gray, Sims, Fu, & Schoelles, 2006) emphasizes the strategic adaptation of information processing strategy to the task environment. It predicts that increasing information access cost (IAC: the time, and physical and mental effort…

  18. 40 CFR 53.54 - Test for proper sampler operation following power interruptions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the AC line electrical power to the sampler 5 times, with durations of 20 seconds, 40 seconds, 2 minutes, 7 minutes, and 20 minutes (respectively), with not less than 10 minutes of normal electrical..., excluding the periods of electrical power interruption. Verify that the elapsed sample time reported by...

  19. 40 CFR 53.54 - Test for proper sampler operation following power interruptions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the AC line electrical power to the sampler 5 times, with durations of 20 seconds, 40 seconds, 2 minutes, 7 minutes, and 20 minutes (respectively), with not less than 10 minutes of normal electrical..., excluding the periods of electrical power interruption. Verify that the elapsed sample time reported by...

  20. 40 CFR 53.54 - Test for proper sampler operation following power interruptions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the AC line electrical power to the sampler 5 times, with durations of 20 seconds, 40 seconds, 2 minutes, 7 minutes, and 20 minutes (respectively), with not less than 10 minutes of normal electrical..., excluding the periods of electrical power interruption. Verify that the elapsed sample time reported by...

  1. 40 CFR 53.54 - Test for proper sampler operation following power interruptions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the AC line electrical power to the sampler 5 times, with durations of 20 seconds, 40 seconds, 2 minutes, 7 minutes, and 20 minutes (respectively), with not less than 10 minutes of normal electrical..., excluding the periods of electrical power interruption. Verify that the elapsed sample time reported by...

  2. The Reasons for the Interruption of Vocational Training in Estonian Vocational Schools

    ERIC Educational Resources Information Center

    Beilmann, Mai; Espenberg, Kerly

    2016-01-01

    Dropping out of school before achieving any qualification is a serious problem both at an individual and societal level. This study provides an insight into the lives of young people who have dropped out or are at a risk of dropping out of vocational schools in Estonia and gives an overview of the reasons behind the interruption of their studies.…

  3. The Effects of Matched Stimulation and Response Interruption and Redirection on Vocal Stereotypy

    ERIC Educational Resources Information Center

    Love, Jessica J.; Miguel, Caio F.; Fernand, Jonathan K.; LaBrie, Jillian K.

    2012-01-01

    Stereotypy has been classified as repetitive behavior that does not serve any apparent function. Two procedures that have been found to reduce rates of vocal stereotypy effectively are response interruption and redirection (RIRD) and noncontingent access to matched stimulation (MS). The purpose of the current study was to evaluate the effects of…

  4. Inflow rates and interrupted flow effects on concentrated flow erosion and intake rate in two soils

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Surface irrigation is the most widely used irrigation practice world wide, but its water use efficiency is low. Interrupted supply of water to furrows may reduce intake rate (IR) upstream and improve irrigation efficiency in many soils, but has an insignificant effect in others. Similarly, intermitt...

  5. A gunner model for an AAA tracking task with interrupted observations

    NASA Technical Reports Server (NTRS)

    Yu, C. F.; Wei, K. C.; Vikmanis, M.

    1982-01-01

    The problem of modeling a trained human operator's tracking performance in an anti-aircraft system under various display blanking conditions is discussed. The input to the gunner is the observable tracking error subjected to repeated interruptions (blanking). A simple and effective gunner model was developed. The effect of blanking on the gunner's tracking performance is approached via modeling the observer and controller gains.

  6. Pardon the Interruption: Enhancing Communication Skills for Students with Intellectual Disability

    ERIC Educational Resources Information Center

    Bayes, Daniel A.; Heath, Amy K.; Williams, Carol; Ganz, Jennifer B.

    2013-01-01

    This article provides teachers and parents with a description of the behavior chain interruption strategy (BCIS), an evidence-based intervention for increasing requesting behaviors in individuals with moderate to severe disabilities. A review of the relevant literature is provided, as well as a description of the behavioral principles that…

  7. The Behavior Chain Interruption Strategy: A Review of Research and Discussion of Future Directions.

    ERIC Educational Resources Information Center

    Carter, Mark; Grunsell, Julie

    2001-01-01

    A review of 10 studies that utilize the behavior chain interruption strategy (BCIS) to teach communication skills to individuals with severe disabilities found that BCIS has been successfully applied to individuals across a wide range of ages and levels of disability, including learners with multiple disabilities. Generalization concerns are…

  8. Computer assessment of indirect insight during an airflow interrupter maneuver of breathing.

    PubMed

    Jabłoński, Ireneusz

    2013-06-01

    The paper answers the questions if it is possible to conclude in objective way on more (than one -Rint - in a classical IT) number of parameters from the time domain post-interrupter signals during the occlusional measurement of respiratory mechanics and also verifies what accuracy can be achieved in such attempt. To obtain reported results, the time-domain enhanced interrupter technique (TD-EIT) was developed in this paper using computer simulations. Three-stage scheme of work was assumed in the project. First, the quality of the model identification was assessed for various combinations of pressure and flow signals recorded during the interruption. Then, the correlation between the working characteristics of the interrupter valve and the precision of the parameter estimation were assessed for the TD-EIT algorithm. Finally, a verification experiment by forward-inverse modeling was organized, in which the mechanical characteristics of a complex model were mapped with reduced analogs and with the use of neural networks for three typical modes: 'Normal state', 'Airway constriction' and 'Cheeks supported'. Obtained results show that to became effective in time-domain post-interrupter data exploration, both pressure and flow signals should be used in assessment of respiratory mechanics, taken in a range of at least 100ms and when both slopes (valve closing and opening) of quasi-step excitation are included. What is more, the faster the valve the smaller error of parameter estimation in proposed TD-EIT was observed, and this uncertainty importantly falls down for the length of time window exceeding the limit of 100ms. The pioneering use of neural network for mapping the mechanical properties of lungs with the use of interrupter experiment methodology proves that it is possible to conclude about more (than one) number of parameters characterizing the complex system and that this insight is biased with the error not exceeding of 10%; only peripheral properties are

  9. Measuring the relationship between interruptions, multitasking and prescribing errors in an emergency department: a study protocol

    PubMed Central

    Raban, Magdalena Z; Walter, Scott R; Douglas, Heather E; Strumpman, Dana; Mackenzie, John; Westbrook, Johanna I

    2015-01-01

    Introduction Interruptions and multitasking are frequent in clinical settings, and have been shown in the cognitive psychology literature to affect performance, increasing the risk of error. However, comparatively less is known about their impact on errors in clinical work. This study will assess the relationship between prescribing errors, interruptions and multitasking in an emergency department (ED) using direct observations and chart review. Methods and analysis The study will be conducted in an ED of a 440-bed teaching hospital in Sydney, Australia. Doctors will be shadowed at proximity by observers for 2 h time intervals while they are working on day shift (between 0800 and 1800). Time stamped data on tasks, interruptions and multitasking will be recorded on a handheld computer using the validated Work Observation Method by Activity Timing (WOMBAT) tool. The prompts leading to interruptions and multitasking will also be recorded. When doctors prescribe medication, type of chart and chart sections written on, along with the patient's medical record number (MRN) will be recorded. A clinical pharmacist will access patient records and assess the medication orders for prescribing errors. The prescribing error rate will be calculated per prescribing task and is defined as the number of errors divided by the number of medication orders written during the prescribing task. The association between prescribing error rates, and rates of prompts, interruptions and multitasking will be assessed using statistical modelling. Ethics and dissemination Ethics approval has been obtained from the hospital research ethics committee. Eligible doctors will be provided with written information sheets and written consent will be obtained if they agree to participate. Doctor details and MRNs will be kept separate from the data on prescribing errors, and will not appear in the final data set for analysis. Study results will be disseminated in publications and feedback to the ED. PMID

  10. Oscillatory pressure transients after flow interruption during bronchial challenge test in children.

    PubMed

    Frey, U; Kraemer, R

    1997-01-01

    The measurement of the conventional interrupter resistance (Rint) is dependent on pressure equilibration between alveolar and airway opening pressure, which is often not achieved in the presence of severe airways obstruction or in small children. The damping properties (d) of postocclusional oscillatory pressure transients after rapid flow interrruption can be assessed independent of complete pressure equilibration, and we have previously shown them to be correlated to resistive properties of the respiratory system. We wanted to determine whether these transients were an expression of acoustic properties of the air in the airways, or whether they were caused by an interaction of gas and lung tissue, and whether d was more sensitive than Rint to changes in airway mechanics. Bronchial challenge tests were carried out with cumulative doses of inhaled carbachol in 10 healthy children (aged 7-14 yrs) and 50 asthmatic children (aged 5-15 yrs). The airflow interruptions were performed with a combined nebulizer-shutter head, allowing resistance measurements with each breath. The frequency, and the damping factor of the postocclusional pressure transients changed significantly during carbachol challenge in both groups of children. The provocation dose (PD) at which the damping factor (d) of the oscillatory pressure transients increased more than 2 SD above the baseline mean ("variance-based", PDvb) was lower than the PDvb of the end-interruption resistance (Rint, EI). These changes in frequency and damping factor were reversible after inhaling salbutamol. These findings suggest that the damping properties of the postocclusional pressure transients after flow interruption can be used as a sensitive parameter to assess changes in airway mechanics during bronchial challenge test in children in whom pressure equilibration is frequently not achieved during airflow interruption due to airways obstruction. PMID:9032496

  11. Long-term outcome of patients after a single interruption of antiretroviral therapy: a cohort study

    PubMed Central

    2012-01-01

    Background To describe the long term outcome of patients who interrupted highly active antiretroviral therapy (HAART) once, identify the variables associated with earlier need to re-start HAART, and the response when therapy was resumed. A retrospective observational cohort of 66 adult patients with HIV-1 infection who interrupted HAART with a CD4+cell count ≥350 cells/μL and undetectable viral load (VL) was performed. The pre-established CD4+ cell count for restarting therapy was 300cells/μL. Cox regression was used to analyse the variables associated with earlier HAART reinitiation. Results The median follow-up was 209 weeks (range, 64–395). Rates of HIV-related or possible HIV-related events were 0.37 (one case of acute retroviral syndrome) and 1.49 per 100 patient-years, respectively. Two patients died after re-starting therapy and having reached undetectable VL. Three patients suffered a sexually transmitted disease while off therapy. Fifty patients (76%) resumed therapy after a median of 97 weeks (range, 17–267). Age, a nadir of CD4+ <250 cells/μL, and a mean VL during interruption of >10,000 copies/ml were independent predictors for earlier re-start. The intention-to-treat success rate of the first HAART resumed regimen was 85.4%. There were no differences by regimen used, nor between regimens that were the same as or different from the one that had been interrupted. Conclusions Our data suggest highly active antiretroviral therapy may be interrupted in selected patients because in these patients, when the HAART is restarted, the viral and clinical response may be achieved. PMID:23095460

  12. 75 FR 70289 - In the Matter of Certain Ground Fault Circuit Interrupters and Products Containing Same; Notice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION In the Matter of Certain Ground Fault Circuit Interrupters and Products Containing Same; Notice of... importation of certain ground fault circuit interrupters and products containing the same. The...

  13. 76 FR 2708 - In the Matter of Certain Ground Fault Circuit Interrupters and Products Containing Same; Notice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-14

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION In the Matter of Certain Ground Fault Circuit Interrupters and Products Containing Same; Notice of... importation of certain ground fault circuit interrupters and products containing the same. The...

  14. 41 CFR 301-70.501 - Does per diem continue when an employee interrupts a travel assignment because of an...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... when an employee interrupts a travel assignment because of an incapacitating illness or injury? 301-70... Policies and Procedures for Emergency Travel of Employee Due to Illness or Injury § 301-70.501 Does per diem continue when an employee interrupts a travel assignment because of an incapacitating illness...

  15. 41 CFR 301-70.501 - Does per diem continue when an employee interrupts a travel assignment because of an...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... when an employee interrupts a travel assignment because of an incapacitating illness or injury? 301-70... Policies and Procedures for Emergency Travel of Employee Due to Illness or Injury § 301-70.501 Does per diem continue when an employee interrupts a travel assignment because of an incapacitating illness...

  16. 41 CFR 301-70.501 - Does per diem continue when an employee interrupts a travel assignment because of an...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... when an employee interrupts a travel assignment because of an incapacitating illness or injury? 301-70... Policies and Procedures for Emergency Travel of Employee Due to Illness or Injury § 301-70.501 Does per diem continue when an employee interrupts a travel assignment because of an incapacitating illness...

  17. 41 CFR 301-70.501 - Does per diem continue when an employee interrupts a travel assignment because of an...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... when an employee interrupts a travel assignment because of an incapacitating illness or injury? 301-70... Policies and Procedures for Emergency Travel of Employee Due to Illness or Injury § 301-70.501 Does per diem continue when an employee interrupts a travel assignment because of an incapacitating illness...

  18. 41 CFR 301-70.501 - Does per diem continue when an employee interrupts a travel assignment because of an...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... when an employee interrupts a travel assignment because of an incapacitating illness or injury? 301-70... Policies and Procedures for Emergency Travel of Employee Due to Illness or Injury § 301-70.501 Does per diem continue when an employee interrupts a travel assignment because of an incapacitating illness...

  19. Use and Outcomes Associated With Bridging During Anticoagulation Interruptions in Patients With Atrial Fibrillation

    PubMed Central

    Peterson, Eric D.; Kim, Sunghee; Thomas, Laine; Gersh, Bernard J.; Fonarow, Gregg C.; Kowey, Peter R.; Mahaffey, Kenneth W.; Sherwood, Matthew W.; Chang, Paul; Piccini, Jonathan P.; Ansell, Jack

    2015-01-01

    Background— Temporary interruption of oral anticoagulation for procedures is often required, and some propose using bridging anticoagulation. However, the use and outcomes of bridging during oral anticoagulation interruptions in clinical practice are unknown. Methods and Results— The Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry is a prospective, observational registry study of US outpatients with atrial fibrillation. We recorded incident temporary interruptions of oral anticoagulation for a procedure, including the use and type of bridging therapy. Outcomes included multivariable-adjusted rates of myocardial infarction, stroke or systemic embolism, major bleeding, cause-specific hospitalization, and death within 30 days. Of 7372 patients treated with oral anticoagulation, 2803 overall interruption events occurred in 2200 patients (30%) at a median follow-up of 2 years. Bridging anticoagulants were used in 24% (n=665), predominantly low-molecular-weight heparin (73%, n=487) and unfractionated heparin (15%, n=97). Bridged patients were more likely to have had prior cerebrovascular events (22% versus 15%; P=0.0003) and mechanical valve replacements (9.6% versus 2.4%; P<0.0001); however, there was no difference in CHA2DS2-VASc scores (scores ≥2 in 94% versus 95%; P=0.5). Bleeding events were more common in bridged than nonbridged patients (5.0% versus 1.3%; adjusted odds ratio, 3.84; P<0.0001). The incidence of myocardial infarction, stroke or systemic embolism, major bleeding, hospitalization, or death within 30 days was also significantly higher in patients receiving bridging (13% versus 6.3%; adjusted odds ratio, 1.94; P=0.0001). Conclusions— Bridging anticoagulation is used in one quarter of anticoagulation interruptions and is associated with higher risk for bleeding and adverse events. These data do not support the use of routine bridging, and additional data are needed to identify best practices concerning

  20. Interrupted Sound

    ERIC Educational Resources Information Center

    DeWell, Robert

    1973-01-01

    Article described a project in the electronic music idiom for use in the intermediate grades that was different, that involved no complicated or expensive apparatus, and that showed an interesting relationship between measurement and rhythm. (Author/RK)

  1. Cost of Power Interruptions to Electricity Consumers in the UnitedStates (U.S.)

    SciTech Connect

    Hamachi LaCommare, Kristina; Eto, Joseph H.

    2006-02-16

    The massive electric power blackout in the northeastern U.S.and Canada on August 14-15, 2003 catalyzed discussions about modernizingthe U.S. electricity grid. Industry sources suggested that investments of$50 to $100 billion would be needed. This work seeks to better understandan important piece of information that has been missing from thesediscussions: What do power interruptions and fluctuations in powerquality (power-quality events) cost electricity consumers? We developed abottom-up approach for assessing the cost to U.S. electricity consumersof power interruptions and power-quality events (referred to collectivelyas "reliability events"). The approach can be used to help assess thepotential benefits of investments in improving the reliability of thegrid. We developed a new estimate based on publicly availableinformation, and assessed how uncertainties in these data affect thisestimate using sensitivity analysis.

  2. Effectiveness of interruptive alerts in increasing application functionality utilization: a controlled trial.

    PubMed

    Turchin, Alexander; James, Oliver D; Godlewski, Eric D; Shubina, Maria; Coley, Christopher M; Gandhi, Tejal K; Broverman, Carol

    2011-06-01

    Medical applications frequently contain a wide range of functionalities. Users are often unaware of all of the functionalities available. More effective ways of delivering information about available functionalities to the users are needed. We conducted a pseudo-randomized controlled trial to determine whether interruptive alerts will increase utilization of several functionalities by the users of the Pre-Admission Medication List (PAML) Builder application at two academic medical centers. In a log-linear model, alerts increased total utilization of the promoted functionalities per PAML built by 70% compared to the controls at the site level (p<0.0001). At the user level, frequency of utilization of the PAML Builder functionalities by individual users increased by 0.03 for every extra alert shown to the user (p<0.0001). Alerts led to a nearly 2-fold increase in utilization of the promoted functionalities. Interruptive alerts are an effective method of delivering information about application functionalities to users. PMID:20637899

  3. The effects of interruptions in work activity: field and laboratory results.

    PubMed

    Eyrolle, H; Cellier, J M

    2000-10-01

    The effects of interruptions in work activity were investigated, first in a field study where the operators' task was to card-index data about customers' phone lines. The interruptions due to customers' calls resulted in an increase of the processing time of the current task and in the use of several management strategies. A laboratory study was then designed in order to study the effects of temporal strain, complexity and similarity on time-sharing efficiency and to clarify the psychological mechanisms underlying the switching from one task to the other. The results showed especially a significant effect of temporal strains on performance and a strong increase in mean error rate at the very beginning of the processing of the second task. In conclusion, advice is given for both technical and organisational design. PMID:11059468

  4. A hybrid metalloarsenate 3D framework-1D interrupted metal oxide.

    PubMed

    Hughes, Robert W; Gerrard, Lee A; Price, Daniel J; Weller, Mark T

    2003-06-30

    Complex metal arsenates of the stoichiometry M(1)(-)(x)()M'(6)(OH)(3)(AsO(4)H(2)(x)()(/3))(3)(HAsO(4)), M = M' = Co, Ni, have been synthesized under hydrothermal conditions. The two compounds display a very similar structural topology to that of the mineral dumortierite, an uncommon complex oxyborosilicate of aluminum. The hybrid structures consist of well separated, vacancy interrupted chains of face sharing MO(6) octahedra, with short M.M distances near 2.5 A, embedded in a metalloarsenate 3D framework having the topology of the aluminosilicate cancrinite. The framework also contains a quadruply bridging hydroxide ion. Magnetic susceptibility measurements reveal a strong antiferromagnetic interaction and magnetic transition to low temperature spin canted phases below 51 K (Co) and 42 K (Ni). The material may be considered as a zeotype framework structure templated by an interrupted one-dimensional metal oxide. PMID:12817976

  5. Switch contact device for interrupting high current, high voltage, AC and DC circuits

    DOEpatents

    Via, Lester C.; Witherspoon, F. Douglas; Ryan, John M.

    2005-01-04

    A high voltage switch contact structure capable of interrupting high voltage, high current AC and DC circuits. The contact structure confines the arc created when contacts open to the thin area between two insulating surfaces in intimate contact. This forces the arc into the shape of a thin sheet which loses heat energy far more rapidly than an arc column having a circular cross-section. These high heat losses require a dramatic increase in the voltage required to maintain the arc, thus extinguishing it when the required voltage exceeds the available voltage. The arc extinguishing process with this invention is not dependent on the occurrence of a current zero crossing and, consequently, is capable of rapidly interrupting both AC and DC circuits. The contact structure achieves its high performance without the use of sulfur hexafluoride.

  6. Safety Profile of Nifurtimox and Treatment Interruption for Chronic Chagas Disease in Colombian Adults

    PubMed Central

    Olivera, Mario Javier; Cucunubá, Zulma M.; Álvarez, Carlos Arturo; Nicholls, Rubén Santiago

    2015-01-01

    Nifurtimox (NFX) is one of the approved drugs used to treat Chagas disease. Safety profile studies and models on risk factors for treatment interruption in adults are scarce in Latin America. This study evaluated retrospectively the medical records of adult Chagas disease patients treated with NFX between 2007 and 2012 in Bogotá, Colombia. An accelerated failure time model was used, and associations were expressed as time ratio (TR). In total, 76 adult patients with NFX were included: 60 (79.0%) completed 60 days of treatment, 61 (80.3%) presented adverse drug reactions (ADRs), and 16 (21.0%) required treatment interruption. The predominant symptoms were epigastric pain (23.7%), nauseas (18.4%), sleep disturbances (18.4%), loss of appetite (17.1%), and temporary loss of memory (15.2%). ADRs were classified as mild (64.5%), moderate (30.4%), and severe (5.1%). Time of treatment was significantly longer when presenting ≤ 3 ADRs (TR: 1.78; 95% CI: 1.04–3.03), presence of non-severe ADRs (TR: 6.52; 95% CI: 3.24–13.1), doses of NFX ≤ 8 mg/kg/day (TR: 1.78; 95% CI: 0.90–3.49), and age < 48 years (TR: 1.57; 95% CI: 0.90–2.74). Treatment with NFX in adults caused a high frequency of ADRs, but most of the cases were mild and did not require treatment interruption. Severity and number of ADRs were the main predictors for treatment interruption. PMID:26392162

  7. Inflammatory activation following interruption of long-term cardiac resynchronization therapy.

    PubMed

    Rubaj, Andrzej; Ruciński, Piotr; Oleszczak, Krzysztof; Trojnar, Michał K; Wójcik, Maciej; Wysokiński, Andrzej; Kutarski, Andrzej

    2013-09-01

    Previous observations suggest that cardiac resynchronization therapy (CRT) may exert an anti-inflammatory effect. The objective of this study was to evaluate the effect of temporary interruption of long-term CRT on plasma concentrations of proinflammatory cytokines and brain natriuretic peptide (BNP). The study group consisted of 54 patients (32 male and 22 female, mean age 64 years) with chronic heart failure (HF) treated with CRT. BNP, high-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and neopterin were measured three times: after 26-28 weeks of continuous CRT (CRT-on), 48 h after its cessation (CRT-off), and 48 h after switching the CRT-on again. CRT interruption resulted in a significant worsening of left ventricular systolic function: reduction of cardiac output (CO), dP/dt, and left ventricular ejection fraction (LVEF), as well as deterioration of mitral regurgitation in the CRT responder group. A significant increase in serum concentrations of hs-CRP, neopterin, IL-6, and BNP was noted in this subpopulation. In CRT nonresponders, no significant changes were observed. In responders the changes in serum concentrations of hs-CRP, IL-6, neopterin, and BNP, following CRT interruption, significantly correlated with the respective changes in thoracic fluid content (TFC) and inversely correlated with LVEF changes. Even short (48 h) interruption of long-term CRT led to a significant increase of proinflammatory cytokines and BNP concentrations in responders. The changes in hs-CRP, IL-6, neopterin, and BNP concentrations correlated with the change in TFC-marker of pulmonary congestion and inversely correlated with the change in LVEF. PMID:23242167

  8. Safety Profile of Nifurtimox and Treatment Interruption for Chronic Chagas Disease in Colombian Adults.

    PubMed

    Olivera, Mario Javier; Cucunubá, Zulma M; Álvarez, Carlos Arturo; Nicholls, Rubén Santiago

    2015-12-01

    Nifurtimox (NFX) is one of the approved drugs used to treat Chagas disease. Safety profile studies and models on risk factors for treatment interruption in adults are scarce in Latin America. This study evaluated retrospectively the medical records of adult Chagas disease patients treated with NFX between 2007 and 2012 in Bogotá, Colombia. An accelerated failure time model was used, and associations were expressed as time ratio (TR). In total, 76 adult patients with NFX were included: 60 (79.0%) completed 60 days of treatment, 61 (80.3%) presented adverse drug reactions (ADRs), and 16 (21.0%) required treatment interruption. The predominant symptoms were epigastric pain (23.7%), nauseas (18.4%), sleep disturbances (18.4%), loss of appetite (17.1%), and temporary loss of memory (15.2%). ADRs were classified as mild (64.5%), moderate (30.4%), and severe (5.1%). Time of treatment was significantly longer when presenting ≤ 3 ADRs (TR: 1.78; 95% CI: 1.04-3.03), presence of non-severe ADRs (TR: 6.52; 95% CI: 3.24-13.1), doses of NFX ≤ 8 mg/kg/day (TR: 1.78; 95% CI: 0.90-3.49), and age < 48 years (TR: 1.57; 95% CI: 0.90-2.74). Treatment with NFX in adults caused a high frequency of ADRs, but most of the cases were mild and did not require treatment interruption. Severity and number of ADRs were the main predictors for treatment interruption. PMID:26392162

  9. Interrupted Aortic Arch Associated with Absence of Left Common Carotid Artery: Imaging with MDCT

    SciTech Connect

    Onbas, Omer Olgun, Hasim; Ceviz, Naci; Ors, Rahmi; Okur, Adnan

    2006-06-15

    Interrupted aortic arch (IAA) is a rare severe congenital heart defect defined as complete luminal and anatomic discontinuity between ascending and descending aorta. Although its association with various congenital heart defects has been reported, absence of left common carotid artery (CCA) in patients with IAA has not been reported previously. We report a case of IAA associated with the absence of left CCA which was clearly shown on multidetector-row spiral CT.

  10. Severe neurological crisis in a patient with hereditary tyrosinaemia type I after interruption of NTBC treatment.

    PubMed

    Schlump, J-U; Perot, C; Ketteler, K; Schiff, M; Mayatepek, E; Wendel, U; Spiekerkoetter, U

    2008-12-01

    Neurological crises do not occur in patients with tyrosinaemia type I treated with NTBC. We report an 8 month-old boy with severe neurological crisis after interruption of NTBC treatment including progressive ascending polyneuropathy and diaphragmatic paralysis, arterial hypertension, respiratory distress requiring mechanical ventilation who later also developed impaired liver function and tubulopathy. After re-introduction of NTBC the patient slowly regained normal neurological functions and recovered completely. PMID:18500574

  11. 1,4-Diketones from Cross-Conjugated Dienones: Potassium Permanganate-Interrupted Nazarov Reaction.

    PubMed

    Kwon, Yonghoon; Schatz, Devon J; West, Frederick G

    2015-08-17

    A domino potassium permanganate-interrupted Nazarov reaction to yield syn-2,3-disubstituted 1,4-diketones via a decarbonylative cleavage of the Nazarov oxyallyl intermediate, believed to be without precedent, is presented. This process allows syn substituents to be established stereospecifically on the 2-carbon bridge connecting the ketone carbonyl carbons, and the formation of one carbon-carbon and two carbon-oxygen bonds. Two carbon-carbon bonds are cleaved in this process. PMID:26138361

  12. Report of the procedure of voluntary interruption of pregnancy at a university hospital in Uruguay

    PubMed Central

    Bentancor, Ana; Hernández, Ana Laura; Godoy, Yamile; Dapueto, Juan J

    2016-01-01

    ABSTRACT OBJECTIVE To describe the constitution and operation of a voluntary interruption of pregnancy team of a university hospital, from the outlook of the mental health team. METHODS In this case study, the following aspects were analyzed: 1) historical background; 2) implementation of Law 18,897 of October 22, 2012; and 3) functioning of the program at the Hospital de Clínicas of the Facultad de Medicina (Universidad de la República, Uruguay), taking into account three dimensions: structure, process, and results. RESULTS Between December 2012 and November 2013, a total of 6,676 voluntary interruptions of pregnancy were reported in Uruguay; out of these, 80 were conducted at the Hospital de Clínicas. The patients’ demographic data agreed with those reported at the national level: Of the total patients, 81.0% were aged over 19 years; 6.2% decided to continue with the pregnancy; and only 70.0% attended the subsequent control and received advice on contraception. CONCLUSIONS In its implementation year in Uruguay, we can assess the experience as positive from the point of view of women’s health. Our experience as a mental health team at the Hospital de Clínicas, inserted into the multidisciplinary voluntary interruption of pregnancy team, is in the process of assessment and reformulation of practices. PMID:27384969

  13. HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.

    PubMed

    Scheid, Johannes F; Horwitz, Joshua A; Bar-On, Yotam; Kreider, Edward F; Lu, Ching-Lan; Lorenzi, Julio C C; Feldmann, Anna; Braunschweig, Malte; Nogueira, Lilian; Oliveira, Thiago; Shimeliovich, Irina; Patel, Roshni; Burke, Leah; Cohen, Yehuda Z; Hadrigan, Sonya; Settler, Allison; Witmer-Pack, Maggi; West, Anthony P; Juelg, Boris; Keler, Tibor; Hawthorne, Thomas; Zingman, Barry; Gulick, Roy M; Pfeifer, Nico; Learn, Gerald H; Seaman, Michael S; Bjorkman, Pamela J; Klein, Florian; Schlesinger, Sarah J; Walker, Bruce D; Hahn, Beatrice H; Nussenzweig, Michel C

    2016-07-28

    Interruption of combination antiretroviral therapy in HIV-1-infected individuals leads to rapid viral rebound. Here we report the results of a phase IIa open label clinical trial evaluating 3BNC117,a broad and potent neutralizing antibody against the CD4 binding site of the HIV-1 Env protein, during analytical treatment interruption in 13 HIV-1-infected individuals. Participants with 3BNC117-sensitive virus outgrowth cultures were enrolled. Results show that two or four 30 mg kg(-1) 3BNC117 infusions,separated by 3 or 2 weeks, respectively, are generally well tolerated.Infusions are associated with a delay in viral rebound of 5-9 weeks after two infusions, and up to 19 weeks after four infusions, or an average of 6.7 and 9.9 weeks, respectively, compared with 2.6 weeks for historical controls (P < 0.00001). Rebound viruses arise predominantly from a single provirus. In most individuals,emerging viruses show increased resistance, indicating escape.However, 30% of participants remained suppressed until antibody concentrations waned below 20 μg ml(-1), and the viruses emerging in all but one of these individuals showed no apparent resistance to 3BCN117, suggesting failure to escape over a period of 9-19 weeks.We conclude that the administration of 3BNC117 exerts strong selective pressure on HIV-1 emerging from latent reservoirs during analytical treatment interruption in humans. PMID:27338952

  14. Enhancing the Simulation Speed of Sensor Network Applications by Asynchronization of Interrupt Service Routines

    PubMed Central

    Joe, Hyunwoo; Woo, Duk-Kyun; Kim, Hyungshin

    2013-01-01

    Sensor network simulations require high fidelity and timing accuracy to be used as an implementation and evaluation tool. The cycle-accurate and instruction-level simulator is the known solution for these purposes. However, this type of simulation incurs a high computation cost since it has to model not only the instruction level behavior but also the synchronization between multiple sensors for their causality. This paper presents a novel technique that exploits asynchronous simulations of interrupt service routines (ISR). We can avoid the synchronization overheads when the interrupt service routines are simulated without preemption. If the causality errors occur, we devise a rollback procedure to restore the original synchronized simulation. This concept can be extended to any instruction-level sensor network simulator. Evaluation results show our method can enhance the simulation speed up to 52% in the case of our experiments. For applications with longer interrupt service routines and smaller number of preemptions, the speedup becomes greater. In addition, our simulator is 2 to 11 times faster than the well-known sensor network simulator. PMID:23966200

  15. Effects of light interruption on sleep and viability of Drosophila melanogaster.

    PubMed

    Liu, Zhenxing; Zhao, Zhangwu

    2014-01-01

    Light is a very important regulator of the daily sleep rhythm. Here, we investigate the influence of nocturnal light stimulation on Drosophila sleep. Results showed that total daytime sleep was reduced due to a decrease in daytime sleep episode duration caused by discontinuous light stimulation, but sleep was not strongly impacted at nighttime although the discontinuous light stimulation occurred during the scotophase. During a subsequent recovery period without light interruption, the sleep quality of nighttime sleep was improved and of daytime sleep reduced, indicating flies have a persistent response to nocturnal light stimulation. Further studies showed that the discontinuous light stimulation damped the daily rhythm of a circadian light-sensitive protein cryptochrome both at the mRNA and protein levels, which subsequently caused disappearance of circadian rhythm of the core oscillator timeless and decrease of TIMLESS protein at nighttime. These data indicate that the nocturnal light interruption plays an important role in sleep through core proteins CRYTOCHROME and TIMLESS, Moreover, interruption of sleep further impacted reproduction and viability. PMID:25148297

  16. Interruption of pulmonary arterial flow with inadequate ventilation leads to pulmonary infection.

    PubMed

    Urano; Shibayama, Y; Fukunshi, K; Nariyama, K; Ohsawa, N

    1996-03-01

    We examined the effect of interruption of pulmonary arterial flow and inadequate ventilation on the development of pulmonary infarction in rats. Pulmonary arterial flow was blocked by the injection of agar into the inferior vena cava and inadequate ventilation was produced by obstructing the left main bronchus with a polypropylene tip. Histological and angiographic examination of the lung demonstrated that: pulmonary artery embolism alone does not induce pulmonary infarction; obstruction of a bronchus does not induce significant changes, but that pulmonary infarction develops when pulmonary artery embolism and obstruction of a bronchus occur simultaneously. It has been thought that pulmonary infarction is caused by acute obstruction of a pulmonary artery, however, the alveolar walls are supplied with oxygen by both the pulmonary circulation and by ventilation. Interruption of pulmonary arterial flow alone is probably not sufficient to induce pulmonary infarction, which is probably caused by deficiency of oxygen supply to the alveolar walls by a synergy between interruption of pulmonary arterial flow and inadequate ventilation. PMID:8605572

  17. An algorithm used for ventricular fibrillation detection without interrupting chest compression.

    PubMed

    Li, Yongqin; Bisera, Joe; Weil, Max Harry; Tang, Wanchun

    2012-01-01

    Ventricular fibrillation (VF) is the primary arrhythmic event in the majority of patients suffering from sudden cardiac arrest. Attention has been focused on this particular rhythm since it is recognized that prompt therapy, especially electrical defibrillation, may lead to a successful outcome. However, current versions of automated external defibrillators (AEDs) mandate repetitive interruptions of chest compression for rhythm analyses since artifacts produced by chest compression during cardiopulmonary resuscitation (CPR) preclude reliable electrocardiographic (ECG) rhythm analysis. Yet, repetitive interruptions in chest compression are detrimental to the success of defibrillation. The capability for rhythm analysis without requiring "hands-off" intervals will allow for more effective resuscitation. In this paper, a novel continuous-wavelet-transformation-based morphology consistency evaluation algorithm was developed for the detection of disorganized VF from organized sinus rhythm (SR) without interrupting the ongoing chest compression. The performance of this method was evaluated on both uncorrupted and corrupted ECG signals recorded from AEDs obtained from out-of-hospital victims of cardiac arrest. A total of 232 patients and 31,092 episodes of either VF or SR were accessed, in which 8195 episodes were corrupted by artifacts produced by chest compressions. We also compared the performance of this method with three other established algorithms, including VF filter, spectrum analysis, and complexity measurement. Even though there was a modest decrease in specificity and accuracy when chest compression artifact was present, the performance of this method was still superior to other reported methods for VF detection during uninterrupted CPR. PMID:21342836

  18. Interruption of aortic arch in adults: surgical experience with extra-anatomic bypass.

    PubMed

    Sai Krishna, C; Bhan, Anil; Sharma, Sanjeev; Kiran, Usha; Venugopal, Panangipalli

    2005-01-01

    We reviewed our 3-year experience in treating interruption of the aorta in adult patients. Clinical profiles, surgical management, and results of early and mid-term follow-up are presented. From August 2001 through June 2003, 7 adult patients underwent an extra-anatomic bypass procedure to repair interruption of the aortic arch. Five patients underwent ventral aortic repair through a mid-sternotomy and an upper midline laparotomy, and 2 patients underwent repair through a left posterolateral thoracotomy. A bovine collagen-impregnated polyester fiber graft was used in 6 patients, and a Gore-Tex graft was interposed in 1 patient. All repairs were performed without cardiopulmonary bypass. Follow-up was complete in all patients. The mean follow-up was 1728 +/- 1 months (range, 9-31 months). No neurologic, renal, or gastrointestinal complications were noted in any patient. There was no in-hospital or late mortality or need for re-intervention. All patients were asymptomatic; however, 5 patients had mild residual hypertension. Graft patency in all the patients was confirmed by computed tomographic angiography. Interruption of the aorta is rare in adults. Ventral aortic repair through a midline approach is our preferred technique for surgical repair of this entity, because it avoids the extensive network of collateral vessels on the chest wall, enables simultaneous treatment of associated lesions, and in all likelihood reduces morbidity and mortality. PMID:16107103

  19. Effects of interrupted photoperiods on the induction of ovulation in anestrous mares.

    PubMed

    Malinowski, K; Johnson, A L; Scanes, C G

    1985-10-01

    The ability of interrupted photoperiods to induce early estrus and ovulation was examined. Horse mares were exposed to long (16 h light) or short (10 h light), noninterrupted photoperiods, ambient light, or various interrupted photoperiod treatments from December 1 to April 15 (135 d). Follicular development was assessed by rectal palpation and estrous behavior was determined by teasing with a stallion. Serum concentrations of progesterone were used as an indicator of corpus luteum function. Differences among the light treatment groups were compared for the following behavioral and ovarian characteristics: days to first detectable 3-cm follicle, days to first estrous behavior, days to first ovulation, the number of mares ovulating within the treatment period, and the number of ovulations within the treatment period per mare. Compared with the ambient and 10L:14D (L = h of light and D = h of darkness) photoperiod treatments, ovulation was advanced to the greatest extent by a photoperiod of 16L:8D and the interrupted photoperiod 10L:8D:2L:4D. These two stimulatory photoperiod treatments were characterized by the presence of light 8 to 10 h after dusk. Therefore, the present data are consistent with an external coincidence model for the induction of seasonal breeding in horses, with the photoinducible phase occurring within the period 8 to 10 h after dusk. PMID:4066545

  20. Role of contextual cues on the perception of spectrally reduced interrupted speech.

    PubMed

    Patro, Chhayakanta; Mendel, Lisa Lucks

    2016-08-01

    Understanding speech within an auditory scene is constantly challenged by interfering noise in suboptimal listening environments when noise hinders the continuity of the speech stream. In such instances, a typical auditory-cognitive system perceptually integrates available speech information and "fills in" missing information in the light of semantic context. However, individuals with cochlear implants (CIs) find it difficult and effortful to understand interrupted speech compared to their normal hearing counterparts. This inefficiency in perceptual integration of speech could be attributed to further degradations in the spectral-temporal domain imposed by CIs making it difficult to utilize the contextual evidence effectively. To address these issues, 20 normal hearing adults listened to speech that was spectrally reduced and spectrally reduced interrupted in a manner similar to CI processing. The Revised Speech Perception in Noise test, which includes contextually rich and contextually poor sentences, was used to evaluate the influence of semantic context on speech perception. Results indicated that listeners benefited more from semantic context when they listened to spectrally reduced speech alone. For the spectrally reduced interrupted speech, contextual information was not as helpful under significant spectral reductions, but became beneficial as the spectral resolution improved. These results suggest top-down processing facilitates speech perception up to a point, and it fails to facilitate speech understanding when the speech signals are significantly degraded. PMID:27586760

  1. Interrupting Malaria Transmission: Quantifying the Impact of Interventions in Regions of Low to Moderate Transmission

    PubMed Central

    Gatton, Michelle L.; Cheng, Qin

    2010-01-01

    Malaria has been eliminated from over 40 countries with an additional 39 currently planning for, or committed to, elimination. Information on the likely impact of available interventions, and the required time, is urgently needed to help plan resource allocation. Mathematical modelling has been used to investigate the impact of various interventions; the strength of the conclusions is boosted when several models with differing formulation produce similar data. Here we predict by using an individual-based stochastic simulation model of seasonal Plasmodium falciparum transmission that transmission can be interrupted and parasite reintroductions controlled in villages of 1,000 individuals where the entomological inoculation rate is <7 infectious bites per person per year using chemotherapy and bed net strategies. Above this transmission intensity bed nets and symptomatic treatment alone were not sufficient to interrupt transmission and control the importation of malaria for at least 150 days. Our model results suggest that 1) stochastic events impact the likelihood of successfully interrupting transmission with large variability in the times required, 2) the relative reduction in morbidity caused by the interventions were age-group specific, changing over time, and 3) the post-intervention changes in morbidity were larger than the corresponding impact on transmission. These results generally agree with the conclusions from previously published models. However the model also predicted changes in parasite population structure as a result of improved treatment of symptomatic individuals; the survival probability of introduced parasites reduced leading to an increase in the prevalence of sub-patent infections in semi-immune individuals. This novel finding requires further investigation in the field because, if confirmed, such a change would have a negative impact on attempts to eliminate the disease from areas of moderate transmission. PMID:21152042

  2. What might interrupt men's suicide? Results from an online survey of men

    PubMed Central

    Shand, Fiona L; Proudfoot, Judy; Player, Michael J; Fogarty, Andrea; Whittle, Erin; Wilhelm, Kay; Hadzi-Pavlovic, Dusan; McTigue, Isabel; Spurrier, Michael; Christensen, Helen

    2015-01-01

    Objectives Men are almost two times more likely to die by suicide than women, yet little research has focused on what is required to prevent suicide among men. This paper aims to investigate what factors interrupt suicidal behaviour in men, and to examine differences according to known suicide risk factors. Setting Australia. Participants 251 Australian men aged 18 years and over who had made a suicide attempt 6–18 months prior to completing the survey. Outcomes The survey canvassed the language men use to describe their depression and suicidality, warning signs, barriers to accessing help and what is needed to interrupt a suicide attempt. ORs and χ2 were used to test for differences by age, geographic location and current depression severity. Results Of 299 men screened and eligible to participate, 251 completed all or part of the survey. Participants identified different words and warning signs for depression compared with suicidality. The most commonly endorsed barriers to accessing help were not wanting to burden others (66%) and having isolated themselves (63%). Men overwhelmingly endorsed ‘I thought about the consequences for my family’ as the factor which stopped a suicide attempt (67%). ‘I need support from someone I really trust and respect’ was also strongly endorsed. There were few differences by age, region or depression severity. Conclusions Participants were able to identify signs, albeit often subtle ones, that they were becoming depressed or suicidal. Similarly, most were able to identify active strategies to interrupt this downward spiral. Men wanted others to notice changes in their behaviour, and to approach them without judgement. PMID:26474936

  3. Successful Interruption of Transmission of Onchocerca volvulus in the Escuintla-Guatemala Focus, Guatemala

    PubMed Central

    Gonzalez, Rodrigo J.; Cruz-Ortiz, Nancy; Rizzo, Nidia; Richards, Jane; Zea-Flores, Guillermo; Domínguez, Alfredo; Sauerbrey, Mauricio; Catú, Eduardo; Oliva, Orlando; Richards, Frank O.; Lindblade, Kim A.

    2009-01-01

    Background Elimination of onchocerciasis (river blindness) through mass administration of ivermectin in the six countries in Latin America where it is endemic is considered feasible due to the relatively small size and geographic isolation of endemic foci. We evaluated whether transmission of onchocerciasis has been interrupted in the endemic focus of Escuintla-Guatemala in Guatemala, based on World Health Organization criteria for the certification of elimination of onchocerciasis. Methodology/Principal Findings We conducted evaluations of ocular morbidity and past exposure to Onchocerca volvulus in the human population, while potential vectors (Simulium ochraceum) were captured and tested for O. volvulus DNA; all of the evaluations were carried out in potentially endemic communities (PEC; those with a history of actual or suspected transmission or those currently under semiannual mass treatment with ivermectin) within the focus. The prevalence of microfilariae in the anterior segment of the eye in 329 individuals (≥7 years old, resident in the PEC for at least 5 years) was 0% (one-sided 95% confidence interval [CI] 0–0.9%). The prevalence of antibodies to a recombinant O. volvulus antigen (Ov-16) in 6,432 school children (aged 6 to 12 years old) was 0% (one-sided 95% IC 0–0.05%). Out of a total of 14,099 S. ochraceum tested for O. volvulus DNA, none was positive (95% CI 0–0.01%). The seasonal transmission potential was, therefore, 0 infective stage larvae per person per season. Conclusions/Significance Based on these evaluations, transmission of onchocerciasis in the Escuintla-Guatemala focus has been successfully interrupted. Although this is the second onchocerciasis focus in Latin America to have demonstrated interruption of transmission, it is the first focus with a well-documented history of intense transmission to have eliminated O. volvulus. PMID:19333366

  4. Understanding the cost of power interruptions to U.S. electricity consumers

    SciTech Connect

    LaCommare, Kristina Hamachi; Eto, Joseph H.

    2004-09-01

    The massive electric power blackout in the northeastern United States and Canada on August 14-15, 2003 resulted in the U.S. electricity system being called ''antiquated'' and catalyzed discussions about modernizing the grid. Industry sources suggested that investments of $50 to $100 billion would be needed. This report seeks to quantify an important piece of information that has been missing from these discussions: how much do power interruptions and fluctuations in power quality (power-quality events) cost U.S. electricity consumers? Accurately estimating this cost will help assess the potential benefits of investments in improving the reliability of the grid. We develop a comprehensive end-use framework for assessing the cost to U.S. electricity consumers of power interruptions and power-quality events (referred to collectively as ''reliability events''). The framework expresses these costs as a function of: (1) Number of customers by type in a region; (2) Frequency and type of reliability events experienced annually (including both power interruptions and power-quality events) by these customers; (3) Cost of reliability events; and (4) Vulnerability of customers to these events. The framework is designed so that its cost estimate can be improved as additional data become available. Using our framework, we estimate that the national cost of power interruptions is about $80 billion annually, based on the best information available in the public domain. However, there are large gaps in and significant uncertainties about the information currently available. Notably, we were not able to develop an estimate of power-quality events. Sensitivity analysis of some of these uncertainties suggests that the total annual cost could range from less than $30 billion to more than $130 billion. Because of this large range and the enormous cost of the decisions that may be based on this estimate, we encourage policy makers, regulators, and industry to jointly under take the

  5. The Effect of Interrupts on Software Pipeline Execution on Message-Passing Architectures

    NASA Technical Reports Server (NTRS)

    VanderWijngaart, Rob F.; Sarukkai, Sekhar R.; Mehra, Pankaj; Craw, James M. (Technical Monitor)

    1995-01-01

    Pipelining is a common strategy for extracting parallelism from a collection of independent computational tasks, each of which is spread among a number of processors and has an implied data dependence. When implemented on MIMD parallel computers with finite process interrupt times, pipeline algorithms suffer from slowdown--in addition to the expected pipeline fill time--due to a wave-like propagation of delays. This phenomenon, which has been observed experimentally using the performance monitoring system AIMS, is investigated analytically, and an optimal correction is derived to eliminate the wave. Efficiency increase through the correction is verified experimentally.

  6. Electric Power Interruption Cost Estimates for Individual Industries, Sectors, and U.S. Economy

    SciTech Connect

    Balducci, Patrick J.; Roop, Joseph M.; Schienbein, Lawrence A.; DeSteese, John G.; Weimar, Mark R.

    2002-02-27

    During the last 20 years, utilities and researchers have begun to understand the value in the collection and analysis of interruption cost data. The continued investigation of the monetary impact of power outages will facilitate the advancement of the analytical methods used to measure the costs and benefits from the perspective of the energy consumer. More in-depth analysis may be warranted because of the privatization and deregulation of power utilities, price instability in certain regions of the U.S. and the continued evolution of alternative auxiliary power systems.

  7. Differential radiosensitivity in cultured B-16 melanoma cells following interrupted melanogenesis induced by glucosamine

    SciTech Connect

    Mileo, A.M.; Mattei, E.; Fanuele, M.; Delpino, A.; Ferrini, U. )

    1989-05-01

    The relationship between cell pigmentation and radiosensitivity was investigated in a cell model in which melanogenesis was suppressed by a glycosylation inhibitor. It was found that X-irradiation of melanotic B-16 melanoma cells and their amelanotic counterparts, obtained by glucosamine treatment, showed an inverse correlation between radiosensitivity and melanin contents. Since melanogenesis interruption by glucosamine does not affect the DNA repair capacity of nonpigmented cells, it is likely that intracellular melanins play a role in the relative resistance of pigmented cells to X-irradiation.

  8. Randomized, Controlled Trial of Therapy Interruption in Chronic HIV-1 Infection

    PubMed Central

    2004-01-01

    Background Approaches to limiting exposure to antiretroviral therapy (ART) drugs are an active area of HIV therapy research. Here we present longitudinal follow-up of a randomized, open-label, single-center study of the immune, viral, and safety outcomes of structured therapy interruptions (TIs) in patients with chronically suppressed HIV-1 infection as compared to equal follow-up of patients on continuous therapy and including a final therapy interruption in both arms. Methods and Findings Forty-two chronically HIV-infected patients on suppressive ART with CD4 counts higher than 400 were randomized 1:1 to either (1) three successive fixed TIs of 2, 4, and 6 wk, with intervening resumption of therapy with resuppression for 4 wk before subsequent interruption, or (2) 40 wk of continuous therapy, with a final open-ended TI in both treatment groups. Main outcome was analysis of the time to viral rebound (>5,000 copies/ml) during the open-ended TI. Secondary outcomes included study-defined safety criteria, viral resistance, therapy failure, and retention of immune reconstitution. There was no difference between the groups in time to viral rebound during the open-ended TI (continuous therapy/single TI, median [interquartile range] = 4 [1–8] wk, n = 21; repeated TI, median [interquartile range] = 5 [4–8] wk, n = 21; p = 0.36). No differences in study-related adverse events, viral set point at 12 or 20 wk of open-ended interruption, viral resistance or therapy failure, retention of CD4 T cell numbers on ART, or retention of lymphoproliferative recall antigen responses were noted between groups. Importantly, resistance detected shortly after initial viremia following the open-ended TI did not result in a lack of resuppression to less than 50 copies/ml after reinitiation of the same drug regimen. Conclusion Cycles of 2- to 6-wk time-fixed TIs in patients with suppressed HIV infection failed to confer a clinically significant benefit with regard to viral suppression off

  9. Astronaut Andrew S. W. Thomas, mission specialist, interrupts a Spacehab task to pose for an

    NASA Technical Reports Server (NTRS)

    1996-01-01

    STS-77 ESC VIEW --- Astronaut Andrew S. W. Thomas, mission specialist, interrupts a Spacehab task to pose for an Electronic Still Camera (ESC) snapshot inside the Spacehab Module onboard the Earth-orbiting Space Shuttle Endeavour. In upper left is the view port which crew members had used for viewing and photographing operations with the Spartan 207/Inflatable Antenna Experiment (IAE). Thomas has his hand on an aft-bulkhead-mounted locker. The Space Experiment Facility (SEF), designed and managed by the University of Alabama, is just behind his left shoulder.

  10. Pre-conditioned place preference treatment of chloral hydrate interrupts the rewarding effect of morphine.

    PubMed

    Sun, YongMei; Zong, Wei; Zhou, MuRu; Ma, YuanYe; Wang, JianHong

    2015-08-01

    The medical use of morphine as a pain killer is hindered by its side effects including dependence and further addiction. As the prototypical μ receptor agonist, morphine's rewarding effect can be measured by conditioned place preference (CPP) paradigms in animals. Chloral hydrate is a clinical sedative. Using a morphine CPP paradigm that mainly contains somatosensory cues, we found that pre-CPP treatment in rats using chloral hydrate for 6 consecutive days could disrupt the establishment of CPP in a U shape. Chloral hydrate had no effect on the body weight of rats. Our results indicate that prior treatment with chloral hydrate can interrupt the rewarding effect of morphine. PMID:26013578

  11. A chemical synthesis of 11-methoxy mitragynine pseudoindoxyl featuring the interrupted Ugi reaction

    PubMed Central

    Kim, Jimin; Schneekloth, John S.

    2013-01-01

    A synthesis of 11-methoxy mitragynine pseudoindoxyl, a new member of the mitragynine class of opioid agonists, from a derivative of the Geissman-Waiss lactone is described. An internal attack of an electron-rich aromatic ring on an electrophilic nitrilium ion and a late-stage construction of the functionalized piperidine ring by the method of reductive cyclization are the pivotal transformations; both ring annulations proceed in a highly diastereoselective fashion. The construction of substituted indoxyl frameworks by the interrupted Ugi method offers an attractive alternative to the strategy of oxidatively rearranging indoles. PMID:23878716

  12. Hydrogen-Borrowing and Interrupted-Hydrogen-Borrowing Reactions of Ketones and Methanol Catalyzed by Iridium**

    PubMed Central

    Shen, Di; Poole, Darren L; Shotton, Camilla C; Kornahrens, Anne F; Healy, Mark P; Donohoe, Timothy J

    2015-01-01

    Reported herein is the use of catalytic [{Ir(cod)Cl}2] to facilitate hydrogen-borrowing reactions of ketone enolates with methanol at 65 °C. An oxygen atmosphere accelerates the process, and when combined with the use of a bulky monodentate phosphine ligand, interrupts the catalytic cycle by preventing enone reduction. Subsequent addition of pro-nucleophiles to the reaction mixture allowed a one-pot methylenation/conjugate addition protocol to be developed, which greatly expands the range of products that can be made by this methodology. PMID:25491653

  13. Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease.

    PubMed

    Optican, Lance M; Rucker, Janet C; Keller, Edward L; Leigh, R John

    2008-01-01

    In late-onset Tay-Sachs disease (LOTS), saccades are interrupted by one or more transient decelerations. Some saccades reaccelerate and continue on before eye velocity reaches zero, even in darkness. Intervals between successive decelerations are not regularly spaced. Peak decelerations of horizontal and vertical components of oblique saccades in LOTS is more synchronous than those in control subjects. We hypothesize that these decelerations are caused by dysregulation of the fastigial nuclei (FN) of the cerebellum, which fire brain stem inhibitory burst neurons (IBNs). PMID:18718355

  14. Decreasing Beam Auto Tuning Interruption Events with In-Situ Chemical Cleaning on Axcelis GSD

    SciTech Connect

    Fuchs, Dieter; Spreitzer, Stefan; Vogl, Josef; Bishop, Steve; Eldridge, David; Kaim, Robert

    2008-11-03

    Ion beam auto tuning time and success rate are often major factors in the utilization and productivity of ion implanters. Tuning software frequently fails to meet specified setup times or recipe parameters, causing production stoppages and requiring manual intervention. Build-up of conductive deposits in the arc chamber and extraction gap can be one of the main causes of auto tuning problems. The deposits cause glitching and ion beam instabilities, which lead to errors in the software optimization routines. Infineon Regensburg has been testing use of XeF{sub 2}, an in-situ chemical cleaning reagent, with positive results in reducing auto tuning interruption events.

  15. A Gonadotropin-Releasing Hormone Agonist Model Demonstrates That Nocturnal Hot Flashes Interrupt Objective Sleep

    PubMed Central

    Joffe, Hadine; Crawford, Sybil; Economou, Nicole; Kim, Semmie; Regan, Susan; Hall, Janet E.; White, David

    2013-01-01

    Objectives: Sleep interruption is often reported by women with hot flashes and night sweats (or vasomotor symptoms, VMS). Although women report that VMS awaken them, polysomnography (PSG) studies have not consistently supported this contention. Design: We mimicked menopause using a gonadotropin-releasing hormone agonist (GnRHa) to investigate whether VMS increase awakenings and wake after sleep onset (WASO). VMS, serum estradiol, and at-home PSGs (two pretreatment, two posttreatment) were measured before and after 4 weeks on GnRHa. Regression models were used to determine the effect of increasing VMS frequency on awakenings and WASO, as measured objectively and subjectively. Participants: Twenty-nine healthy women (mean 27.3 y). Setting: Academic medical center. Interventions: Depot GnRHa (leuprolide 3.75-mg). Results: Serum estradiol was rapidly and uniformly suppressed on GnRHa. Persistent VMS were reported by 69% of women. The number of nighttime VMS correlated directly with the degree of sleep disturbance. Each additional reported nighttime VMS was associated with a 62% increase from baseline in PSG-measured WASO (P = 0.007), a 3% increase in awakenings (P = 0.05), and 6% increase in %N1 sleep (P = 0.02). Nighttime VMS were also associated with increased perceived WASO (312%; P = 0.02), awakenings (16%; P = 0.007), Insomnia Severity Index (P = 0.03), and Pittsburgh Sleep Quality Index (P = 0.03) scores, and decreased perceived sleep efficiency (P = 0.01). Objectively recorded nighttime VMS correlated with PSG-measured WASO (rs = 0.45, P = 0.02). Conclusions: This menopause model demonstrates that nighttime vasomotor symptoms correlate with increased sleep fragmentation. These findings are consistent with a specific contribution of vasomotor symptoms to polysomnography-measured sleep interruption suggesting that nighttime vasomotor symptoms interrupt sleep in the setting of menopause. Citation: Joffe H; Crawford S; Economou N; Kim S; Regan S; Hall JE; White D. A

  16. Recovery from prior stimulation: Masking of speech by interrupted noise for younger and older adults with normal hearing

    NASA Astrophysics Data System (ADS)

    Dubno, Judy R.; Horwitz, Amy R.; Ahlstrom, Jayne B.

    2003-04-01

    In a previous study [Dubno et al., J. Acoust. Soc. Am. 111, 2897-2907 (2002)], older subjects benefitted less than younger subjects from momentary improvements in signal-to-noise ratio when listening to speech in interrupted maskers. It has been hypothesized that the benefit derived from interrupted maskers may be related to recovery from forward masking, i.e., the recovery of a response to a suprathreshold signal from prior stimulation by a masker. The effect of interrupted maskers on speech recognition may be well suited to test hypotheses regarding recovery from prior stimulation, given that both involve the perception of signals following a masker. Here, younger and older adults with normal but not identical audiograms listened to nonsense syllables at moderate and high levels in a speech-shaped noise that was modulated by a 2-, 10-, 25-, or 50-Hz square wave. An additional low-level noise was always present that was shaped to produce equivalent masked thresholds for all subjects. To assess recovery from forward masking, forward-masked thresholds were measured at 0.5 and 4.0 kHz as a function of the delay between the speech-shaped masker and the signal. Speech recognition in interrupted noise was poorer for older than younger subjects. Small but consistent age-related differences were observed in the decrease in score with interrupted noise relative to the score without interrupted noise. Forward-masked thresholds of older subjects were higher than those of younger subjects, but there were no age-related differences in the amount of forward masking or in simultaneous masking. Negative correlations were observed between speech-recognition scores in interrupted noise and forward-masked thresholds. That is, the benefit derived from momentary improvements in speech audibility in an interrupted noise decreased as forward-masked thresholds increased. Stronger correlations with forward masking were observed for the higher frequency signal, for higher noise

  17. [Programmed cell death as a target to interrupt the aging program].

    PubMed

    Severin, F F; Skulachev, V P

    2009-01-01

    There are two opposite points of view on aging of organisms. The canonic concept assumes that aging is a stochastic process consisting in age-dependent accumulation of occasional injuries in living systems. However, many pieces of evidence are recently obtained in favor of the alternative scheme suggesting that aging is genetically programmed being the final step of ontogenesis. The latter concept predicts that (i) non-aging species should exist who has lost the aging program and (ii) the program in question can experimentally be interrupted by manipulating with corresponding genes or by low molecules operating as inhibitors of execution of aging program. In this paper, we summarize observations which are consistent with two above predictions. In both cases, interruption of the aging program is based upon inhibition of programmed cell death (apoptosis) mediated by mitochondrial reactive oxygen species (ROS). It is stated that the main difference between young and old multicellular organisms consists in the cellularity, i. e. in number of functional cells in organs or tissues rather than in quality of these cells. The cellularity decreases due to domination of apoptosis over proliferation in aging organisms. This means that apoptosis appears to be the basis for aging program. A pharmacological approach to switch off the aging program is considered, which is used mitochondria-targeted antioxidants and uncouplers. Such compounds prevent mitochondrial oxidative stress increasing with age and stimulating the age-dependent apoptosis. PMID:19827675

  18. Interruption of Onchocerca volvulus transmission in the Abu Hamed focus, Sudan.

    PubMed

    Higazi, Tarig B; Zarroug, Isam M A; Mohamed, Hanan A; Elmubark, Wigdan A; Deran, Tong Chor M; Aziz, Nabil; Katabarwa, Moses; Hassan, Hassan K; Unnasch, Thomas R; Mackenzie, Charles D; Richards, Frank; Hashim, Kamal

    2013-07-01

    Abu Hamed, Sudan, the northernmost location of onchocerciasis in the world, began community-directed treatment with ivermectin (CDTI) in 1998, with annual treatments enhanced to semiannual in 2007. We assessed the status of the parasite transmission in 2011 entomologically, parasitologically, and serologically. O-150 pool screening showed no parasite DNA in 17,537 black flies collected in 2011 (95% confidence interval upper limit [95% CI UL] = 0.023). Skin microfilariae, nodules, and signs of skin disease were absent in 536 individuals in seven local communities. Similarly, no evidence of Onchocerca volvulus Ov16 antibodies was found in 6,756 school children ≤ 10 years (95% CI UL = 0.03%). Because this assessment of the focus meets the 2001 World Health Organization (WHO) criteria for interrupted transmission, treatment was halted in 2012, and a post-treatment surveillance period was initiated in anticipation of declaration of disease elimination in this area. We provide the first evidence in East Africa that long-term CDTI alone can interrupt transmission of onchocerciasis. PMID:23690554

  19. Plants cause ecosystem nutrient depletion via the interruption of bird-derived spatial subsidies.

    PubMed

    Young, Hillary S; McCauley, Douglas J; Dunbar, Robert B; Dirzo, Rodolfo

    2010-02-01

    Plant introductions and subsequent community shifts are known to affect nutrient cycling, but most such studies have focused on nutrient enrichment effects. The nature of plant-driven nutrient depletions and the mechanisms by which these might occur are relatively poorly understood. In this study we demonstrate that the proliferation of the commonly introduced coconut palm, Cocos nucifera, interrupts the flow of allochthonous marine subsidies to terrestrial ecosystems via an indirect effect: impact on birds. Birds avoid nesting or roosting in C. nucifera, thus reducing the critical nutrient inputs they bring from the marine environment. These decreases in marine subsidies then lead to reductions in available soil nutrients, decreases in leaf nutrient quality, diminished leaf palatability, and reduced herbivory. This nutrient depletion pathway contrasts the more typical patterns of nutrient enrichment that follow plant species introductions. Research on the effects of spatial subsidy disruptions on ecosystems has not yet examined interruptions driven by changes within the recipient community, such as plant community shifts. The ubiquity of coconut palm introductions across the tropics and subtropics makes these observations particularly noteworthy. Equally important, the case of C. nucifera provides a strong demonstration of how plant community changes can dramatically impact the supply of allochthonous nutrients and thereby reshape energy flow in ecosystems. PMID:20133852

  20. Cockpit Interruptions and Distractions: An Analysis of ASRS Reports and an Experimental Program

    NASA Technical Reports Server (NTRS)

    Dismukes, R. K.; Young, Grant E.; Connors, Mary (Technical Monitor)

    1998-01-01

    A recent detailed analysis of 107 ASRS incident reports focusing on interruptions and distractions as their primary feature revealed several interesting and surprising findings. Of those tasks that were interfered with, over 40% fell within the category of monitoring; for example, monitoring the autopilot flying the aircraft, monitoring the pilot flying, or monitoring the altimeter or navigation instruments for future action. Surprisingly, over 60% of the tasks that were considered distractions fell under the broad category of communication or conversation. Using these findings, we have developed an experimental paradigm that will help us understand the method by which pilots perform certain monitoring tasks. Specifically, we hope to determine the degree to which pilots rely on internal time mechanisms versus external cues as a means of successfully completing a monitoring task. In addition, we will incorporate a battery of competing aviation type tasks, including communication, to see how these tasks affect the process of monitoring. The long range goal of this research is to find operational solutions that facilitate effective monitoring in the presence of both sudden interruptions and distractions that lead to unintended multiple tasks situations.

  1. Interrupting violence: how the CeaseFire Program prevents imminent gun violence through conflict mediation.

    PubMed

    Whitehill, Jennifer M; Webster, Daniel W; Frattaroli, Shannon; Parker, Elizabeth M

    2014-02-01

    Cities are increasingly adopting CeaseFire, an evidence-based public health program that uses specialized outreach workers, called violence interrupters (VIs), to mediate potentially violent conflicts before they lead to a shooting. Prior research has linked conflict mediation with program-related reductions in homicides, but the specific conflict mediation practices used by effective programs to prevent imminent gun violence have not been identified. We conducted case studies of CeaseFire programs in two inner cities using qualitative data from focus groups with 24 VIs and interviews with eight program managers. Study sites were purposively sampled to represent programs with more than 1 year of implementation and evidence of program effectiveness. Staff with more than 6 months of job experience were recruited for participation. Successful mediation efforts were built on trust and respect between VIs and the community, especially high-risk individuals. In conflict mediation, immediate priorities included separating the potential shooter from the intended victim and from peers who may encourage violence, followed by persuading the parties to resolve the conflict peacefully. Tactics for brokering peace included arranging the return of stolen property and emphasizing negative consequences of violence such as jail, death, or increased police attention. Utilizing these approaches, VIs are capable of preventing gun violence and interrupting cycles of retaliation. PMID:23440488

  2. Phasic and Tonic Pain Differentially Impact the Interruptive Function of Pain

    PubMed Central

    Sinke, Christopher; Schmidt, Katharina; Forkmann, Katarina; Bingel, Ulrike

    2015-01-01

    The interruptive effect of painful experimental stimulation on cognitive processes is a well-known phenomenon. This study investigated the influence of pain duration on the negative effects of pain on cognition. Thirty-four healthy volunteers performed a rapid serial visual presentation task (RSVP) in which subjects had to detect (visual detection task) and count the occurrence of a target letter (working memory task) in two separate sessions while being stimulated on the left volar forearm with either short (2 sec) or long (18 sec) painful heat stimuli of equal subjective intensity. The results show that subjects performed significantly worse in the long pain session as indexed by decreased detection and counting performance. Interestingly, this effect on performance was also observed during control trials of the long pain session in which participants did not receive any painful stimulation. Moreover, subjects expected long painful stimulation to have a greater impact on their performance and individual expectation correlated with working memory performance. These findings suggest that not only the length of painful stimulation but also its expected ability to impair cognitive functioning might influence the interruptive function of pain. The exact relevance of expectation for the detrimental effects of pain on cognitive processes needs to be explored in more detail in future studies. PMID:25695254

  3. Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis

    PubMed Central

    Wu, Tong; Hong, Yun; Jia, Lihua; Wu, Jie; Xia, Juan; Wang, Juan; Hu, Qinchao; Cheng, Bin

    2016-01-01

    Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia and squamous cell carcinoma (SCC) stages. Recently, increasing evidence has suggested that the tumor microenvironment (TME) is an integral part of malignant transformation. Exploring certain key node genes in TME for future intervention in dysplasia to interrupt oral carcinogenesis was the primary goal of this research. To achieve this goal, systems biology approaches were first applied to the epithelia and fibroblasts collected at sequential stages in a 4-nitroquinoline-1-oxide (4NQO) - induced rat oral carcinogenesis model. Through bioinformatics network construction, IL-1β was identified as one of the key node genes in TME during carcinogenesis. Immunohistochemical staining of human and rat samples demonstrated that IL-1β expression patterns were parallel to the stages of malignant transformation. Silencing IL-1β with lentivirus-delivered shRNA significantly inhibited oral squamous cell carcinoma cell growth both in vivo and in vitro. Based on these findings, we hypothesized that IL-1β may be a chemoprevention target in TME during oral carcinogenesis. Therefore, we targeted IL-1 in the TME by oral mucosal injection of an IL-1 receptor antagonist in 4NQO rats. The results demonstrated that targeting IL-1 could interrupt oral carcinogenesis by reprogramming the TME. PMID:26831400

  4. Unemployment and work interruption among African American single mothers: effects on parenting and adolescent socioemotional functioning.

    PubMed

    McLoyd, V C; Jayaratne, T E; Ceballo, R; Borquez, J

    1994-04-01

    Using interview data from a sample of 241 single African American mothers and their seventh- and eighth-grade children, this study tests a model of how 2 economic stressors, maternal unemployment and work interruption, influence adolescent socioemotional functioning. In general, these economic stressors affected adolescent socioemotional functioning indirectly, rather than directly, through their impact on mothers' psychological functioning and, in turn, parenting behavior and mother-child relations. Current unemployment, but not past work interruption, had a direct effect on depressive symptomatology in mothers. As expected, depressive symptomatology in mothers predicted more frequent maternal punishment of adolescents, and this relation was fully mediated by mothers' negative perceptions of the maternal role. More frequent maternal punishment was associated with increased cognitive distress and depressive symptoms in adolescents, and consistent with predictions, these relations were partially mediated by adolescents' perceptions of the quality of relations with their mothers. Increased availability of instrumental support, as perceived by mothers, predicted fewer depressive symptoms in mothers, less punishment of adolescents, and less negativity about the maternal role. Both economic stressors were associated with higher levels of perceived financial strain in mothers, which in turn predicted adolescents' perceptions of economic hardship. Adolescents who perceived their families as experiencing more severe economic hardship reported higher anxiety, more cognitive distress, and lower self-esteem. PMID:8013240

  5. Generalized Negative Reciprocity in the Dictator Game – How to Interrupt the Chain of Unfairness

    PubMed Central

    Strang, Sabrina; Grote, Xenia; Kuss, Katarina; Park, Soyoung Q.; Weber, Bernd

    2016-01-01

    Humans are tremendously sensitive to unfairness. Unfairness provokes strong negative emotional reactions and influences our subsequent decision making. These decisions might not only have consequences for ourselves and the person who treated us unfairly but can even transmit to innocent third persons – a phenomenon that has been referred to as generalized negative reciprocity. In this study we aimed to investigate whether regulation of emotions can interrupt this chain of unfairness. Real allocations in a dictator game were used to create unfair situations. Three different regulation strategies, namely writing a message to the dictator who made an unfair offer, either forwarded or not forwarded, describing a neutral picture and a control condition in which subjects just had to wait for three minutes, were then tested on their ability to influence the elicited emotions. Subsequently participants were asked to allocate money between themselves and a third person. We show that writing a message which is forwarded to the unfair actor is an effective emotion regulation strategy and that those participants who regulated their emotions successfully by writing a message made higher allocations to a third person. Thus, using message writing as an emotion regulation strategy can interrupt the chain of unfairness. PMID:26924557

  6. Effects of Political Conflict Induced Treatment Interruptions on HIV Drug Resistance

    PubMed Central

    Mann, Marita; Lurie, Mark N.; Kimaiyo, Sylvester; Kantor, Rami

    2013-01-01

    34 million people worldwide were living with the Human Immunodeficiency Virus (HIV) by the end of 2010. Despite significant advances in antiretroviral therapy (ART), drug resistance remains a major deterrent to successful, enduring treatment. Unplanned interruptions in ART have negative effects on HIV treatment outcomes including increased morbidity and mortality, as well as development of drug resistance. Treatment interruptions due to political conflicts, not infrequent in resource-limited settings, result in disruptions in health care, infrastructure, or treatment facilities and patient displacement. Such circumstances are ideal bases for ART resistance development, however there is limited awareness of and data available on the association between political conflicts and the development of HIV drug resistance. In this review we identify and discuss this association and review how varying ART half-lives, genetic barriers, different HIV subtypes, and archived resistance can lead to lack of medication effectiveness upon post-conflict resumption of care. Optimized ART stopping strategies as well as infrastructural concerns and stable HIV treatment systems to ensure continuity of care and rapid resumption of care must be addressed in order to mitigate risks of HIV drug resistance development during and after political conflicts. Increased awareness of such associations by clinicians as well as politicians and stakeholders is essential. PMID:23449225

  7. Masking of spondees by interrupted noise in hearing-impaired listeners.

    PubMed

    Punch, J L

    1978-01-01

    The effects of changing the duty cycle of an interrupted-broad band masker on the spondee thresholds of hearing-impaired subjects were explored. Two diagnostic groups of sensorineural hearing loss, presbycusics and cochlear otosclerotics, were investigated. The interruption rate of the masker was 10/sec, and its duty cycle was varied at 25% intervals. Thresholds also were obtained in continuous noise and in quiet. Results when compared with earlier data from normal listeners revealed that subjects with sensorineural impairment exhibited poorer performance in all instances, including the continuous noise condition, when mean masker levels were adjusted to comparable sound pressure levels. The overall pattern of masking was more similar for the normal and hearing-impaired groups when performance was equated in terms of the mean threshold shift each group experienced in continuous noise. Even under these circumstances, however, hearing-impaired subjects demostrated notably greater residual masking under the 25 and 50% noise-on conditions. A major determinant of speech reception in fluctuating noise backgrounds is the dependence of the pattern of masking upon the difference between an individual's masked threshold in continuous noise and his threshold in quiet, rather than upon the sound pressure level of the masker. PMID:681196

  8. Enantiodivergent Synthesis of Bis-Spiropyrrolidines via Sequential Interrupted and Completed (3 + 2) Cycloadditions.

    PubMed

    Conde, Egoitz; Rivilla, Iván; Larumbe, Amaia; Cossío, Fernando P

    2015-12-01

    Both (5R)- and (5S)-1,7-diazaspiro[4.4]nonan-6-ones are obtained via a sequence of interrupted and completed stepwise (3 + 2) cycloadditions between azomethine ylides and π-deficient alkenes. The only source of chirality along the whole process is an enantiopure ferrocenyl pyrrolidine catalytic ligand. When the starting imine incorporates two aryl groups or one aryl group with one electron-releasing substituent, the reaction between the azomethine ylide and the alkene stops at the first step, leading to the corresponding Michael adduct. When imines derived from p-methoxybenzaldehyde are used, the corresponding syn-α-amino-γ-nitro ester is obtained with almost complete enantiocontrol. In contrast, imines derived from benzophenone lead to the corresponding anti analogue. From this interrupted (3 + 2) cycloaddition, cis- and trans-α-amino-γ-lactams can be obtained via hydrogenation of the nitro group followed by in situ cyclization. Imines derived from these latter compounds are the precursors of N-metalated azomethine ylides from which up to four new chiral centers can be generated via completed (3 + 2) cycloaddition reactions with full regio- and diastereocontrol. Cis- and trans-γ-lactams lead to opposite bis-spiropyrrolidine enantiomers. Therefore, both enantiomeric series of spiro compounds can be obtained by means of the same catalytic system. The potential of these rigid, densely substituted homochiral compounds in medicinal chemistry is briefly described. PMID:26439974

  9. Generalized Negative Reciprocity in the Dictator Game--How to Interrupt the Chain of Unfairness.

    PubMed

    Strang, Sabrina; Grote, Xenia; Kuss, Katarina; Park, Soyoung Q; Weber, Bernd

    2016-01-01

    Humans are tremendously sensitive to unfairness. Unfairness provokes strong negative emotional reactions and influences our subsequent decision making. These decisions might not only have consequences for ourselves and the person who treated us unfairly but can even transmit to innocent third persons--a phenomenon that has been referred to as generalized negative reciprocity. In this study we aimed to investigate whether regulation of emotions can interrupt this chain of unfairness. Real allocations in a dictator game were used to create unfair situations. Three different regulation strategies, namely writing a message to the dictator who made an unfair offer, either forwarded or not forwarded, describing a neutral picture and a control condition in which subjects just had to wait for three minutes, were then tested on their ability to influence the elicited emotions. Subsequently participants were asked to allocate money between themselves and a third person. We show that writing a message which is forwarded to the unfair actor is an effective emotion regulation strategy and that those participants who regulated their emotions successfully by writing a message made higher allocations to a third person. Thus, using message writing as an emotion regulation strategy can interrupt the chain of unfairness. PMID:26924557

  10. Characteristics and consequences of medical care interruptions in HIV-infected patients in France.

    PubMed

    Cuzin, L; Dellamonica, P; Yazdanpanah, Y; Bouchez, S; Rey, D; Hoen, B; Cabié, A

    2016-08-01

    To describe the consequences of medical care interruptions (MCIs) we selected patients with at least two medical encounters between January 2006 and June 2013 in the Dat'AIDS cohort. Patients with any time interval >15 months between two visits were defined as having a MCI, as opposed to uninterrupted follow-up (UFU). Patients' characteristics at the time of HIV diagnosis and at the censoring date were compared between groups. Cox proportional hazards models were built to assess the role of interruptions on survival (total and AIDS-free). Of 11 116 patients, 824 had at least one MCI. These patients were younger at the time of HIV diagnosis (30 vs. 33 years, P < 0·0001). MCI was less frequent in men having sex with men vs. heterosexual patients [odds ratio (OR) 0·81, 95% confidence interval (CI) 0·69-0·96)], and a centre effect was described. MCI was independently associated with AIDS (OR 2·54, 95% CI 2·10-3·09) and death (OR 2·65, 95% CI 1·94-3·61). At the censoring date, 52·2% of patients with at least one MCI had viral load below detection vs. 85·3% of the UFU group (P < 0·0001). In conclusion, MCIs were associated with patients' survival and with the proportion of viral loads below detection in our cohort, compromising individual and collective treatment benefits. PMID:27033595

  11. Feasibility of global measles eradication after interruption of transmission in the Americas.

    PubMed

    de Quadros, Ciro A; Andrus, Jon Kim; Danovaro-Holliday, M Carolina; Castillo-Solórzano, Carlos

    2008-04-01

    Measles is one of the most infectious diseases. Before the introduction of the measles vaccine, nearly all children contracted measles. By the end of the 1980s, most countries of the world had incorporated the measles vaccine into their routine vaccination programs. Globally, some 345,000 deaths due to measles still occur every year. Eradication of measles would play an important role in improving child survival. The goal to eradicate measles from the Americas was set by the Pan-American Sanitary Conference in 1994. Progress to date has been remarkable. Measles is no longer an endemic disease in the Americas and interruption of transmission has been documented in most countries. As of December 2007, 5 years have elapsed since the detection of the last endemic case in Venezuela in November 2002. This experience demonstrates that interruption of measles transmission can be achieved and sustained over a long period of time. Global eradication should be feasible if the appropriate strategies are implemented. Even in a new paradigm in which eradication is not followed by the discontinuation of vaccination, eradication of measles should be a good investment to avoid expensive epidemics and save those children that would potentially die due to infection with the measles virus. It is not only a dream to think that we will see a world free of measles by the year 2015. PMID:18393605

  12. CD4+ guided antiretroviral treatment interruption in HIV infection: a meta-analysis.

    PubMed

    Seminari, Elena; De Silvestri, Annalisa; Boschi, Andrea; Tinelli, Carmine

    2008-01-01

    The aim of this meta-analysis study was to evaluate the relative risk of death or AIDS-defining events associated to CD4+ guided treatment interruption in patients with chronic HIV infection. A search was conducted using PubMed and Cochrane Library; key words for PubMed were: "antiretroviral therapy and interrupt*" in the full papers from January 1, 2000 up to and including December 31, 2007. To limit the publication bias, clinical trials performed on the topic of the meta-analysis were searched also on http://www.clinicaltrial.gov. Inclusion criteria of studies were: starting a CD4+ guided interruption of HAART in HIV chronically infected patients with CD4+ cell count > 350 cells/mm3, age > 13 years old, and absence of concomitant use of immunomodulatory drugs. Using a conservative approach, to be included in the meta-analysis, studies had to have a follow up period > 100 person years to minimize the bias of a too short observation time. The studies were classified into two categories: randomized clinical trial (one arm stops therapy and other arms continues HAART) and cohort studies. For each study measures of effect (hazard ratio or incidence rate ratio) were reported, when available, uncorrected and corrected for potential confounders. Publication bias was assessed graphically through funnel plot. Pooled relative risk and pooled risk difference were calculated by use of a random effects model following the DerSimonian-Laird method. Observational studies were considered separately and the incidence of primary endpoint was evaluated in each study and the cumulative incidence was calculated. Of the 555 full papers found, all abstracts were screened and 58 full text articles for potential inclusion were retrieved and 18 were retained (seven randomized clinical trials and 11 observational studies). In randomized clinical trials, the meta-analysis showed that the pooled relative risk of AIDS-defining event or mortality was 2.50 (95% CI: 1.87-3.34; p < 0.001); the

  13. Influence of allowable interruption period on estimates of accelerometer wear time and sedentary time in older adults

    PubMed Central

    Mailey, Emily L.; Gothe, Neha P.; Wójcicki, Thomas R.; Szabo, Amanda N.; Olson, Erin A.; Mullen, Sean P.; Fanning, Jason T.; Motl, Robert W.; McAuley, Edward

    2013-01-01

    The criteria one uses to reduce accelerometer data can profoundly influence the interpretation of research outcomes. The purpose of this study was to examine the influence of three different interruption periods (i.e., 20, 30, and 60 minutes) on the amount of data retained for analyses and estimates of sedentary time among older adults. Older adults (N=311; Mage=71.1) wore an accelerometer for seven days and reported wear time on an accelerometer log. Accelerometer data were downloaded and scored using 20, 30, and 60-minute interruption periods. Estimates of wear time derived using each interruption period were compared to self-reported wear time, and descriptive statistics were used to compare estimates of sedentary time. Results showed a longer interruption period (i.e., 60 minutes) yields the largest sample size and the closest approximation of self-reported wear time. A short interruption period (i.e., 20 minutes) is likely to underestimate sedentary time among older adults. PMID:23752299

  14. Learning from Accident and Error: Avoiding the Hazards of Workload, Stress, and Routine Interruptions in the Emergency Department

    PubMed Central

    Morrison, J. Bradley; Rudolph, Jenny W.

    2012-01-01

    This article presents a model of how a build-up of interruptions can shift the dynamics of the emergency department (ED) from an adaptive, self-regulating system into a fragile, crisis-prone one. Drawing on case studies of organizational disasters and insights from the theory of high-reliability organizations, the authors use computer simulations to show how the accumulation of small interruptions could have disproportionately large effects in the ED. In the face of a mounting workload created by interruptions, EDs, like other organizational systems, have tipping points, thresholds beyond which a vicious cycle can lead rather quickly to the collapse of normal operating routines and in the extreme to a crisis of organizational paralysis. The authors discuss some possible implications for emergency medicine, emphasizing the potential threat from routine, non-novel demands on EDs and raising the concern that EDs are operating closer to the precipitous edge of crisis as ED crowding exacerbates the problem. PMID:22168187

  15. Learning from accident and error: avoiding the hazards of workload, stress, and routine interruptions in the emergency department.

    PubMed

    Morrison, J Bradley; Rudolph, Jenny W

    2011-12-01

    This article presents a model of how a build-up of interruptions can shift the dynamics of the emergency department (ED) from an adaptive, self-regulating system into a fragile, crisis-prone one. Drawing on case studies of organizational disasters and insights from the theory of high-reliability organizations, the authors use computer simulations to show how the accumulation of small interruptions could have disproportionately large effects in the ED. In the face of a mounting workload created by interruptions, EDs, like other organizational systems, have tipping points, thresholds beyond which a vicious cycle can lead rather quickly to the collapse of normal operating routines and in the extreme to a crisis of organizational paralysis. The authors discuss some possible implications for emergency medicine, emphasizing the potential threat from routine, non-novel demands on EDs and raising the concern that EDs are operating closer to the precipitous edge of crisis as ED crowding exacerbates the problem. PMID:22168187

  16. Alveolar macrophage kinetics and function after interruption of canine marrow function

    SciTech Connect

    Springmeyer, S.C.; Altman, L.C.; Kopecky, K.J.; Deeg, H.J.; Storb, R.

    1982-03-01

    To study the kinetics and function of alveolar macrophages after interruption of marrow function, we performed serial bronchoalveolar lavages in dogs. The studies were performed before and after 9.0 to 9.5 Grey total body irradiation and marrow infusion. Monocytes had disappeared from the bloodstream by Day 7 after the irradiation. Alveolar macrophages were significantly decreased at Day 21. At Days 14 and 21 myeloperoxidase-positive alveolar macrophages were also significantly decreased. Beyond Day 30 the number of circulating monocytes, myeloperoxidase-positive and total alveolar macrophages had returned. Sex chromatin stains of alveolar macrophages obtained from a male dog that received female marrow indicated that the repopulating macrophages were of marrow origin. In vitro studies of alveolar macrophage migration and phagocytosis demonstrated increased activities beyond Day 30. These studies suggest that in this model the alveolar macrophage is dependent on the bone marrow for support and that the alveolar macrophage depletion may impair lung defense mechanisms.

  17. Brief Therapy Based on Interrupting Ironic Processes: The Palo Alto Model

    PubMed Central

    Rohrbaugh, Michael J.; Shoham, Varda

    2009-01-01

    The model of brief therapy developed by Fisch, Weakland, Watzlawick, and colleagues in Palo Alto is based on identifying and interrupting ironic processes that occur when repeated attempts to solve a problem keep the problem going or make it worse. Formulations of ironic problem-solution loops provide a template for assessment and strategic intervention, indicating where to look to understand what keeps a problem going (look for “more of the same” solution) and what needs to happen for the complaint to be resolved (someone must apply “less of the same” solution). Supporting research is preliminary but suggests this approach may be well suited for change-resistant clients. PMID:19997533

  18. Individual differences in top-down restoration of interrupted speech: links to linguistic and cognitive abilities.

    PubMed

    Benard, Michel Ruben; Mensink, Jorien Susanne; Başkent, Deniz

    2014-02-01

    Top-down restoration mechanisms can enhance perception of degraded speech. Even in normal hearing, however, a large variability has been observed in how effectively individuals can benefit from these mechanisms. To investigate if this variability is partially caused by individuals' linguistic and cognitive skills, normal-hearing participants of varying ages were assessed for receptive vocabulary (Peabody Picture Vocabulary Test; PPVT-III-NL), for full-scale intelligence (Wechsler Adult Intelligence Scale; WAIS-IV-NL), and for top-down restoration of interrupted speech (with silent or noise-filled gaps). Receptive vocabulary was significantly correlated with the other measures, suggesting linguistic skills to be highly involved in restoration of degraded speech. PMID:25234920

  19. Note: A compact three-axis optical force/torque sensor using photo-interrupters

    NASA Astrophysics Data System (ADS)

    Kim, Ji-Chul; Kim, Kyung-Soo; Kim, Soohyun

    2013-12-01

    By integrating four photo-interrupters in a cross-shaped structure, we developed a compact three-axis optical force/torque (F/T) sensor. The developed sensor has a diameter of 28 mm and a thickness of 7 mm. Despite simplicity and compactness, the experiments with a prototype of the proposed sensor demonstrate notably high accuracy. The RMS errors are 0.5% ± 0.1% of the maximum vertical force in z-axis, 1.9% ± 0.2% of the maximum torque in x-axis, and 2.0% ± 0.3% of the maximum torque in y-axis. It is expected that the proposed sensor allows cost-effective integration of robot systems requiring compact and multi-axis F/T sensors such as a walking assist robot.

  20. Note: A compact three-axis optical force/torque sensor using photo-interrupters.

    PubMed

    Kim, Ji-Chul; Kim, Kyung-Soo; Kim, Soohyun

    2013-12-01

    By integrating four photo-interrupters in a cross-shaped structure, we developed a compact three-axis optical force/torque (F/T) sensor. The developed sensor has a diameter of 28 mm and a thickness of 7 mm. Despite simplicity and compactness, the experiments with a prototype of the proposed sensor demonstrate notably high accuracy. The RMS errors are 0.5% ± 0.1% of the maximum vertical force in z-axis, 1.9% ± 0.2% of the maximum torque in x-axis, and 2.0% ± 0.3% of the maximum torque in y-axis. It is expected that the proposed sensor allows cost-effective integration of robot systems requiring compact and multi-axis F/T sensors such as a walking assist robot. PMID:24387485

  1. Interruption of Somatic Embryogenesis in Daucus carota L. by 5-Bromodeoxyuridine

    PubMed Central

    Thomas, John C.; Nessler, Craig; Katterman, Frank

    1989-01-01

    Embryogenic Daucus carota L. cells grown in 9 micromolar 2.4-dichlorophenoxyacetic acid are resistant to greater than 5 micromolar 5-bromodeoxyuridine (BrdU). In contrast, 5 micromolar BrdU strongly inhibits somatic embryogenesis within 24 hours after transfer of cells to an auxin-free medium. DNA synthesis rates in control and BrdU-treated cultures are rapid and similar; however, the DNA content does not reach levels as great in the presence of BrdU as in control cultures. BrdU substitutes for thymidine in the DNA in 28% of the available sites 48 hours after auxin removal. Following DNA repair, somatic embryogenesis resumes. BrdU DNA incorporation leads to somatic embryogenesis inhibition and provides an alternative to auxin treatment for the interruption of carrot cell culture differentiation. Images Figure 2 Figure 3 Figure 7 PMID:16666898

  2. Motion-induced interruptions and postural equilibrium in linear lateral accelerations.

    PubMed

    Matsangas, P; McCauley, M E; Gehl, G; Kiser, J; Bandstra, A; Blankenship, J; Pierce, E

    2014-01-01

    This study assesses lateral tipping motion-induced interruptions (MIIs) in a simulated motion environment. The objective is to revisit MII occurrence and sway motion relationship by focusing on the frequency and acceleration of the lateral motion stimulus. Results verify that MIIs increase with increasing peak sway acceleration, but the effect of sway frequency is not as clear as that of acceleration. Complex multidirectional motions create more tipping MIIs than unidirectional motion. Research should incorporate acceleration, frequency and motion complexity as factors influencing MII occurrence. To describe a temporary loss of balance without tipping, the term 'probable' MII is introduced. This term fills the gap between the theoretical definition and a human-centred perception of an MII where loss of balance is not a binary phenomenon. The 'probable' MIIs were 16-67% more common than the 'definite' MIIs. The developed mathematical model of MII occurrence versus sway acceleration (amplitude, frequency) approximated the observed MIIs with less than 9% difference. PMID:24646414

  3. Galvanostatic interruption of lithium insertion into magnetite: Evidence of surface layer formation

    NASA Astrophysics Data System (ADS)

    Brady, Nicholas W.; Knehr, K. W.; Cama, Christina A.; Lininger, Christianna N.; Lin, Zhou; Marschilok, Amy C.; Takeuchi, Kenneth J.; Takeuchi, Esther S.; West, Alan C.

    2016-07-01

    Magnetite is a known lithium intercalation material, and the loss of active, nanocrystalline magnetite can be inferred from the open-circuit potential relaxation. Specifically, for current interruption after relatively small amounts of lithium insertion, the potential first increases and then decreases, and the decrease is hypothesized to be due to a formation of a surface layer, which increases the solid-state lithium concentration in the remaining active material. Comparisons of simulation to experiment suggest that the reactions with the electrolyte result in the formation of a thin layer of electrochemically inactive material, which is best described by a nucleation and growth mechanism. Simulations are consistent with experimental results observed for 6, 8 and 32-nm crystals. Furthermore, simulations capture the experimental differences in lithiation behavior between the first and second cycles.

  4. Creating a Fontan fenestration in a child with dextrocardia and interrupted inferior vena cava

    PubMed Central

    Charlagorla, Pradeepkumar; Breinholt, John P.

    2016-01-01

    Plastic bronchitis is a rare life-threatening complication of the Fontan operation. Transcatheter Fontan fenestration can ameliorate symptoms by decompressing elevated venous pressures. Transcatheter creation of a fenestration can be technically challenging in cases with complex venous anatomy. We report a case of a 5-year-old boy with heterotaxy, dextrocardia with unbalanced atrioventricular canal (AVC), atrial and visceral situs inversus, left-sided superior vena cava (SVC), and left-sided interrupted inferior vena cava (IVC) with azygos continuation. With few modifications to the equipment, a successful Fontan fenestration with stent implantation was performed via transjugular approach. At 2-year follow-up, his symptoms of plastic bronchitis improved significantly. PMID:27212858

  5. Microstructural characterization of bainitic steel submitted to torsion testing and interrupted accelerated cooling

    SciTech Connect

    Cota, A.B.; Santos, D.B.

    2000-03-01

    HSLA low-carbon bainitic steel containing B was submitted to torsion tests to simulate controlled rolling, followed by interrupted accelerated cooling. Microstructural characteristics and the mechanisms for the refinement of structure were evaluated using light microscopy, scanning electron microscopy, transmission electron microscopy, and Vickers hardness testing. The final microstructure was found to contain complex mixture of granular bainite, small islands of MA constituent, bainitic ferrite, and polygonal ferrite. Increasing the cooling rate of decreasing the finish cooling temperature resulted in a decrease in the volume fraction and average size of the MA islands and the polygonal ferrite. A finish cooing temperature of 400 C produced a microstructure consisting of fine laths of bainitic ferrite with an interlath MA constituent. A quantitative relationship between the accelerated cooling variables and the ferrite grain size was developed.

  6. Estimates of thermal fatigue due to beam interruptions for an ALMR-type ATW

    SciTech Connect

    Dunn, F. E.; Wade, D. C.

    1999-11-12

    Thermal fatigue due to beam interruptions has been investigated in a sodium cooled ATW using the Advanced Liquid Metal mod B design as a basis for the subcritical source driven reactor. A k{sub eff} of 0.975 was used for the reactor. Temperature response in the primary coolant system was calculated, using the SASSYS- 1 code, for a drop in beam current from full power to zero in 1 microsecond.. Temperature differences were used to calculate thermal stresses. Fatigue curves from the American Society of Mechanical Engineers Boiler and Pressure Vessel Code were used to determine the number of cycles various components should be designed for, based on these thermal stresses.

  7. Brief Report: Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials.

    PubMed

    Treasure, Graham C; Aga, Evgenia; Bosch, Ronald J; Mellors, John W; Kuritzkes, Daniel R; Para, Michael; Gandhi, Rajesh T; Li, Jonathan Z

    2016-07-01

    Viral load (VL) rebound timing and set point were analyzed in 235 participants undergoing analytic treatment interruption (ATI) in 6 AIDS Clinical Trials Group studies. There was no significant association between rebound timing and ATI VL set point for those who rebounded ≤12 weeks. VL set points were lower in participants with rebound >12 weeks (P < 0.001) and participants treated during early infection (P < 0.001). Pre-antiretroviral therapy VL correlated with set point, though 68% of participants had a set point lower than pre-antiretroviral therapy VL. These results illustrate complex relationships between post-ATI virologic outcomes and the potential presence of biological factors mediating rebound timing and set point. PMID:26910502

  8. THE EFFECTS OF MATCHED STIMULATION AND RESPONSE INTERRUPTION AND REDIRECTION ON VOCAL STEREOTYPY

    PubMed Central

    Love, Jessica J; Miguel, Caio F; Fernand, Jonathan K; LaBrie, Jillian K

    2012-01-01

    Stereotypy has been classified as repetitive behavior that does not serve any apparent function. Two procedures that have been found to reduce rates of vocal stereotypy effectively are response interruption and redirection (RIRD) and noncontingent access to matched stimulation (MS). The purpose of the current study was to evaluate the effects of RIRD alone, MS alone, and MS combined with RIRD. One participant's results suggested similar suppressive effects on vocal stereotypy across treatment conditions. For the second participant, a slightly greater suppression of stereotypy was associated with MS + RIRD. In addition, both participants emitted a greater frequency of appropriate vocalizations in conditions with RIRD. Data suggest that the addition of MS might facilitate the implementation of RIRD in applied settings. PMID:23060668

  9. Interruption of vector transmission by native vectors and “the art of the possible”

    PubMed Central

    Salvatella, Roberto; Irabedra, Pilar; Castellanos, Luis G

    2013-01-01

    In a recent article in the Reader’s Opinion, advantages and disadvantages of the certification processes of interrupted Chagas disease transmission (American trypanosomiasis) by native vector were discussed. Such concept, accepted by those authors for the case of endemic situations with introduced vectors, has been built on a long and laborious process by endemic countries and Subregional Initiatives for Prevention, Control and Treatment of Chagas, with Technical Secretariat of the Pan American Health Organization/World Health Organization, to create a horizon target and goal to concentrate priorities and resource allocation and actions. With varying degrees of sucess, which are not replaceable for a certificate of good practice, has allowed during 23 years to safeguard the effective control of transmission of Trypanosoma cruzi not to hundreds of thousands, but millions of people at risk conditions, truly “the art of the possible.” PMID:24626310

  10. Creating a Fontan fenestration in a child with dextrocardia and interrupted inferior vena cava.

    PubMed

    Charlagorla, Pradeepkumar; Breinholt, John P

    2016-01-01

    Plastic bronchitis is a rare life-threatening complication of the Fontan operation. Transcatheter Fontan fenestration can ameliorate symptoms by decompressing elevated venous pressures. Transcatheter creation of a fenestration can be technically challenging in cases with complex venous anatomy. We report a case of a 5-year-old boy with heterotaxy, dextrocardia with unbalanced atrioventricular canal (AVC), atrial and visceral situs inversus, left-sided superior vena cava (SVC), and left-sided interrupted inferior vena cava (IVC) with azygos continuation. With few modifications to the equipment, a successful Fontan fenestration with stent implantation was performed via transjugular approach. At 2-year follow-up, his symptoms of plastic bronchitis improved significantly. PMID:27212858

  11. Immediate and subsequent effects of response interruption and redirection on targeted and untargeted forms of stereotypy.

    PubMed

    Pastrana, Sarah J; Rapp, John T; Frewing, Tyla M

    2013-07-01

    A number of studies have shown that response interruption and redirection (RIRD) decreases immediate engagement in targeted stereotypic behaviors; however, its effects on untargeted stereotypy have not yet been studied, and its effects following removal of treatment are unclear. We evaluated the immediate and subsequent effects of RIRD on targeted motor stereotypy, as well as untargeted but higher probability vocal stereotypy, of two participants diagnosed with autism, using a three-component multiple-schedule design. Treatment with RIRD decreased immediate engagement in motor stereotypy for both participants, and did not increase subsequent engagement above baseline levels for either participant. In addition, RIRD produced modest changes in immediate engagement in untargeted vocal stereotypy for both participants. We briefly discuss the clinical implications and limitations of the findings from this study. PMID:23620376

  12. Brief Report: Relationship Among Viral Load Outcomes in HIV Treatment Interruption Trials

    PubMed Central

    Treasure, Graham C.; Aga, Evgenia; Bosch, Ronald J.; Mellors, John W.; Kuritzkes, Daniel R.; Para, Michael; Gandhi, Rajesh T.

    2016-01-01

    Abstract: Viral load (VL) rebound timing and set point were analyzed in 235 participants undergoing analytic treatment interruption (ATI) in 6 AIDS Clinical Trials Group studies. There was no significant association between rebound timing and ATI VL set point for those who rebounded ≤12 weeks. VL set points were lower in participants with rebound >12 weeks (P < 0.001) and participants treated during early infection (P < 0.001). Pre-antiretroviral therapy VL correlated with set point, though 68% of participants had a set point lower than pre-antiretroviral therapy VL. These results illustrate complex relationships between post-ATI virologic outcomes and the potential presence of biological factors mediating rebound timing and set point. PMID:26910502

  13. Galvanostatic interruption of lithium insertion into magnetite: Evidence of surface layer formation

    DOE PAGESBeta

    Nicholas W. Brady; Takeuchi, Esther S.; Knehr, K. W.; Cama, Christina A.; Lininger, Christianna N.; Lin, Zhou; Marschilok, Amy C.; Takeuchi, Kenneth J.; West, Alan C.

    2016-05-05

    Magnetite is a known lithium intercalation material, and the loss of active, nanocrystalline magnetite can be inferred from the open-circuit potential relaxation. Specifically, for current interruption after relatively small amounts of lithium insertion, the potential first increases and then decreases, and the decrease is hypothesized to be due to a formation of a surface layer, which increases the solid-state lithium concentration in the remaining active material. Comparisons of simulation to experiment suggest that the reactions with the electrolyte result in the formation of a thin layer of electrochemically inactive material, which is best described by a nucleation and growth mechanism.more » Simulations are consistent with experimental results observed for 6, 8 and 32-nm crystals. As a result, simulations capture the experimental differences in lithiation behavior between the first and second cycles.« less

  14. Tafazzin knockdown interrupts cell cycle progression in cultured neonatal ventricular fibroblasts.

    PubMed

    He, Quan; Wang, Miao; Harris, Nicole; Han, Xianlin

    2013-11-01

    Mutation of the mitochondrial protein tafazzin causes dilated cardiomyopathy in Barth syndrome. Previous studies have shown that tafazzin knockdown promotes hypertrophy of neonatal cardiac myocytes. The current investigation was designed to show whether tafazzin knockdown affects cardiac fibroblast proliferation and collagen secretion, which contribute to fibrosis in dilated cardiomyopathy. In primary cultures of neonatal ventricular fibroblasts (NVFs) transduced with a tafazzin short hairpin RNA adenovirus, tafazzin knockdown increased production of reactive oxygen species and activation of mitogen-activated protein kinases and induced protein and DNA synthesis via cell cycle regulators. It also reduced intracellular ATP, activated AMPK, and caused multinucleation, hypertrophy, and enhanced collagen secretion. We concluded that tafazzin knockdown interrupts the NVF cell cycle and this in turn may contribute to fibrosis and dilated cardiomyopathy in Barth syndrome. PMID:23997105

  15. Syndrome d'interruption de la tige pituitaire à révélation tardive

    PubMed Central

    Marmouch, Héla; Graja, Samah; Arfa, Sondes; Boubaker, Fadia; Khochtali, Ines

    2016-01-01

    Le syndrome d'interruption de la tige pituitaire est une cause assez fréquente de déficit en hormone de croissance et d'hypopituitarisme souvent révélé pendant la période néonatale et l'enfance. Cette observation illustre les particularités d'une révélation tardive de ce syndrome. Il s'agit d'une patiente âgée de 17ans hospitalisée pour aménorrhée primaire et impubérisme. Elle n'a pas d'antécédent d'incident néonatal. L'examen clinique révèle un retard de croissance sévère. L'hypophysiogramme a montré un hypopituitarisme complet sans diabète insipide. L'imagerie par résonnance magnétique a montré une interruption de la tige pituitaire avec une post hypophyse ectopique. Une malformation rénale a été objectivée, ce qui est en faveur d'une origine congénitale malformative de ce syndrome. Une substitution hormonale a été administrée à cette patiente. Cette forme clinique tardive souligne la nécessité de diagnostic précoce d'impubérisme et/ou de retard de croissance révélant une pathologie à potentiel de gravité important. PMID:27231511

  16. Activation and interruption of the reproduction of Varroa destructor is triggered by host signals (Apis mellifera).

    PubMed

    Frey, Eva; Odemer, Richard; Blum, Thomas; Rosenkranz, Peter

    2013-05-01

    The reproductive cycle of the parasitic mite Varroa destructor is closely linked to the development of the honey bee host larvae. Using a within colony approach we introduced phoretic Varroa females into brood cells of different age in order to analyze the capacity of certain stages of the honey bee larva to either activate or interrupt the reproduction of Varroa females. Only larvae within 18 h (worker) and 36 h (drones), respectively, after cell capping were able to stimulate the mite's oogenesis. Therewith we could specify for the first time the short time window where honey bee larvae provide the signals for the activation of the Varroa reproduction. Stage specific volatiles of the larval cuticle are at least part of these activation signals. This is confirmed by the successful stimulation of presumably non-reproducing mites to oviposition by the application of a larval extract into the sealed brood cells. According to preliminary quantitative GC-MS analysis we suggest certain fatty acid ethyl esters as candidate compounds. If Varroa females that have just started with egg formation are transferred to brood cells containing host larvae of an elder stage two-thirds of these mites stopped their oogenesis. This confirms the presence of an additional signal in the host larvae allowing the reproducing mites to adjust their own reproductive cycle to the ontogenetic development of the host. From an adaptive point of view that sort of a stop signal enables the female mite to save resources for a next reproductive cycle if the own egg development is not sufficiently synchronized with the development of the host. The results presented here offer the opportunity to analyze exactly those host stages that have the capacity to activate or interrupt the Varroa reproduction in order to identify the crucial host signals. PMID:23376006

  17. Effect of weak, interrupted sinusoidal low frequency magnetic field on neural regeneration in rats: functional evaluation.

    PubMed

    Bervar, Marijan

    2005-07-01

    A study of the effect of weak, interrupted sinusoidal low frequency magnetic field (ISMF) stimulation on regeneration of the rat sciatic nerve was carried out. In the experiment, 60 Wistar rats were used: 24 rats underwent unilateral sciatic nerve transection injury and immediate surgical nerve repair, 24 rats underwent unilateral sciatic nerve crush injury, and the remaining 12 rats underwent a sham surgery. Half of the animals (n = 12) with either sciatic nerve lesion were randomly chosen and exposed between a pair of Helmholtz coils for 3 weeks post-injury, 4 h/day, to an interrupted (active period to pause ratio = 1.4 s/0.8 s) sinusoidal 50 Hz magnetic field of 0.5 mT. The other half of the animals (n = 12) and six rats with sham surgery were used for two separate controls. Functional recovery was followed for 6 weeks for the crush injuries and 7(1/2) months for the transection injuries by video assisted footprint analysis in static conditions and quantified using a recently revised static sciatic index (SSI) formula. We ascertained that the magnetic field influence was weak, but certainly detectable in both injury models. The accuracy of ISMF influence detection, determined by the one-way repeated measures ANOVA test, was better for the crush injury model: F(1, 198) = 9.0144, P = .003, than for the transection injury model: F(1, 198) = 6.4826, P = .012. The Student-Newman-Keuls range test for each response day yielded significant differences (P < .05) between the exposed and control groups early in the beginning of functional recovery and later on from the points adjacent to the beginning of the plateau, or 95% of functional recovery, and the end of observation. These differences probably reflect the ISMF systemic effect on the neuron cell bodies and increased and more efficient reinnervation of the periphery. PMID:15887258

  18. One-Stage Repair of an Interrupted Aortic Arch with an Aortopulmonary Window in a Premature Neonate

    PubMed Central

    Bobos, Dimitrios; Kanakis, Meletios A.; Koulouri, Sofia; Giannopoulos, Nicholas M.

    2015-01-01

    Interrupted aortic arch with an aortopulmonary window is a rare congenital entity that is associated with high morbidity and mortality, especially in premature low-birth-weight infants, and the proper timing of surgical correction remains a matter of debate. We present the case of a premature infant weighing 1.6 kg who successfully underwent one stage surgical repair to treat interrupted aortic arch with an aortopulmonary window. The therapeutic management of this patient is described below, and a review of the literature is presented. PMID:26665109

  19. Long-Lasting Insecticidal Nets Are Synergistic with Mass Drug Administration for Interruption of Lymphatic Filariasis Transmission in Nigeria

    PubMed Central

    Eigege, Abel; Miri, Emmanuel; Sallau, Adamu; Umaru, John; Mafuyai, Hayward; Chuwang, Yohanna S.; Danjuma, Goshit; Danboyi, Jacob; Adelamo, Solomon E.; Mancha, Bulus S.; Okoeguale, Bridget; Patterson, Amy E.; Rakers, Lindsay; Richards, Frank O.

    2013-01-01

    In central Nigeria Anopheles mosquitoes transmit malaria and lymphatic filariasis (LF). The strategy used for interrupting LF transmission in this area is annual mass drug administration (MDA) with albendazole and ivermectin, but after 8 years of MDA, entomological evaluations in sentinel villages showed continued low-grade mosquito infection rates of 0.32%. After long-lasting insecticidal net (LLIN) distribution by the national malaria program in late 2010, however, we were no longer able to detect infected vectors over a 24-month period. This is evidence that LLINs are synergistic with MDA in interrupting LF transmission. PMID:24205421

  20. Finite Buffer GI/M(n)/1 Queue with Bernoulli-Schedule Vacation Interruption under N-Policy

    PubMed Central

    Vijaya Laxmi, P.; Suchitra, V.

    2014-01-01

    We study a finite buffer N-policy GI/M(n)/1 queue with Bernoulli-schedule vacation interruption. The server works with a slower rate during vacation period. At a service completion epoch during working vacation, if there are at least N customers present in the queue, the server interrupts vacation and otherwise continues the vacation. Using the supplementary variable technique and recursive method, we obtain the steady state system length distributions at prearrival and arbitrary epochs. Some special cases of the model, various performance measures, and cost analysis are discussed. Finally, parameter effect on the performance measures of the model is presented through numerical computations. PMID:27355076

  1. Effect of Growth Interruption on Surface Recombination Velocity in GaInAsSb/AlGaAsSb Heterostructures Grown by Organometallic Vapor Phase Epitaxy

    SciTech Connect

    CA Wang; DA Shiau; D Donetsky; S Anikeev; G Belenky; S Luryi

    2004-04-29

    The effects of growth interruption on the quality of GaInAsSb/AlGaAsSb heterostructures grown by organometallic vapor phase epitaxy are reported. In-situ reflectance monitoring and ex-situ characterization by high-resolution x-ray diffraction, 4K photoluminescence (PL), and time-resolved PL indicate that GaInAsSb is extremely sensitive to growth interruption time as well as the ambient atmosphere during interruption. By optimizing the interruption sequence, surface recombination velocity as low as 20 cm/s was achieved for GaInAsSb/AlGaAsSb double heterostructures.

  2. Increase in nitrate uptake by soybean plants during interruption of the dark period with low intensity light

    NASA Technical Reports Server (NTRS)

    Raper, C. D. Jr; Vessey, J. K.; Henry, L. T.

    1991-01-01

    Diurnal patterns of net NO3- uptake by nonnodulated soybean [Glycine max (L.) Merr. cv. Ransom] plants growing in flowing hydroponic culture at 26 and 16 degrees C root temperatures were measured at hourly intervals during alternate days of a 12-day growth period. Ion chromatography was used to determine removal of NO3- from the culture solution. Day and night periods of 9 and 15 h were used during growth. The night period included two 6-h dark periods and an intervening 3-h period of night interruption by incandescent lamps to effect a long-day photoperiod and repress floral initiation. At both root temperatures, the average specific rates of NO3- uptake were twice as great during the night interruption period as during the day period; they were greater during the day period than during the dark periods; and they were greater during the dark period immediately following the day period than during the later dark period that followed the night interruption. While these average patterns were repetitious among days, measured rates of uptake varied hourly and included intervals of net efflux scattered through the day period and more frequently through the 2 dark periods. Root temperature did not affect the average daily specific rates of uptake or the qualitative relationships among day, dark and night interruption periods of the diurnal cycle.

  3. Technical Note: The use of an interrupted-flow centrifugation method to characterise preferential flow in low permeability media

    NASA Astrophysics Data System (ADS)

    Crane, R. A.; Cuthbert, M. O.; Timms, W.

    2015-09-01

    We present an interrupted-flow centrifugation technique to characterise preferential flow in low permeability media. The method entails a minimum of three phases: centrifuge-induced flow, no flow and centrifuge-induced flow, which may be repeated several times in order to most effectively characterise multi-rate mass transfer behaviour. In addition, the method enables accurate simulation of relevant in situ total stress conditions during flow by selecting an appropriate centrifugal force. We demonstrate the utility of the technique for characterising the hydraulic properties of smectite-clay-dominated core samples. All core samples exhibited a non-Fickian tracer breakthrough (early tracer arrival), combined with a decrease in tracer concentration immediately after each period of interrupted flow. This is indicative of dual (or multi-)porosity behaviour, with solute migration predominately via advection during induced flow, and via molecular diffusion (between the preferential flow network(s) and the low hydraulic conductivity domain) during interrupted flow. Tracer breakthrough curves were simulated using a bespoke dual porosity model with excellent agreement between the data and model output (Nash-Sutcliffe model efficiency coefficient was > 0.97 for all samples). In combination, interrupted-flow centrifuge experiments and dual porosity transport modelling are shown to be a powerful method to characterise preferential flow in low permeability media.

  4. Technical Note: The use of an interrupted-flow centrifugation method to characterise preferential flow in low permeability media

    NASA Astrophysics Data System (ADS)

    Crane, R. A.; Cuthbert, M. O.; Timms, W.

    2015-01-01

    We present an interrupted-flow centrifugation technique to characterise preferential flow in low permeability media. The method entails a minimum of three phases: centrifuge induced flow, no flow and centrifuge induced flow, which may be repeated several times in order to most effectively characterise multi-rate mass transfer behaviour. In addition, the method enables accurate simulation of relevant in situ total stress conditions during flow by selecting an appropriate centrifugal force level. We demonstrate the utility of the technique for characterising the hydraulic properties of smectite clay dominated core samples. All samples exhibited a non-Fickian tracer breakthrough (early tracer arrival), combined with a decrease in tracer concentration immediately after each period of interrupted-flow. This is indicative of dual (or multi) porosity behaviour, with solute migration predominately via advection during induced flow, and via molecular diffusion (between the preferential flow network(s) and the low hydraulic conductivity domain) during interrupted-flow. Tracer breakthrough curves were simulated using a bespoke dual porosity model with excellent agreement between the data and model output (Nash-Sutcliffe model efficiency coefficient was >0.97 for all samples). In combination interrupted-flow centrifuge experiments and dual porosity transport modelling are shown to be a powerful method to characterise preferential flow in low permeability media.

  5. Perception of interrupted speech: Effects of dual-rate gating on the intelligibility of words and sentencesa

    PubMed Central

    Shafiro, Valeriy; Sheft, Stanley; Risley, Robert

    2011-01-01

    Perception of interrupted speech and the influence of speech materials and memory load were investigated using one or two concurrent square-wave gating functions. Sentences (Experiment 1) and random one-, three-, and five-word sequences (Experiment 2) were interrupted using either a primary gating rate alone (0.5−24 Hz) or a combined primary and faster secondary rate. The secondary rate interrupted only speech left intact after primary gating, reducing the original speech to 25%. In both experiments, intelligibility increased with primary rate, but varied with memory load and speech material (highest for sentences, lowest for five-word sequences). With dual-rate gating of sentences, intelligibility with fast secondary rates was superior to that with single rates and a 25% duty cycle, approaching that of single rates with a 50% duty cycle for some low and high rates. For dual-rate gating of words, the positive effect of fast secondary gating was smaller than for sentences, and the advantage of sentences over word-sequences was not obtained in many dual-rate conditions. These findings suggest that integration of interrupted speech fragments after gating depends on the duration of the gated speech interval and that sufficiently robust acoustic-phonetic word cues are needed to access higher-level contextual sentence information. PMID:21973362

  6. The Interrupted Time Series as Quasi-Experiment: Three Tests of Significance. A Fortran Program for the CDC 3400 Computer.

    ERIC Educational Resources Information Center

    Sween, Joyce; Campbell, Donald T.

    Computational formulae for the following three tests of significance, useful in the interrupted time series design, are given: (1) a "t" test (Mood, 1950) for the significance of the first post-change observation from a value predicted by a linear fit of the pre-change observations; (2) an "F" test (Walker and Lev, 1953) of the hypothesis that one…

  7. Use of Transnational Services to Prevent Treatment Interruption in Tuberculosis-Infected Persons Who Leave the United States.

    PubMed

    Tschampl, Cynthia A; Garnick, Deborah W; Zuroweste, Edward; Razavi, Moaven; Shepard, Donald S

    2016-03-01

    A major problem resulting from interrupted tuberculosis (TB) treatment is the development of drug-resistant TB, including multidrug-resistant TB (MDR TB), a more deadly and costly-to-treat form of the disease. Global health systems are not equipped to diagnose and treat the current burden of MDR TB. TB-infected foreign visitors and temporary US residents who leave the country during treatment can experience treatment interruption and, thus, are at greater risk for drug-resistant TB. Using epidemiologic and demographic data, we estimated TB incidence among this group, as well as the proportion of patients referred to transnational care-continuity and management services during relocation; each year, ≈2,827 visitors and temporary residents are at risk for TB treatment interruption, 222 (8%) of whom are referred for transnational services. Scale up of transnational services for persons at high risk for treatment interruption is possible and encouraged because of potential health gains and reductions in healthcare costs for the United States and receiving countries. PMID:26886720

  8. Synchronizing Bees With Bloom: Interrupted Incubation and Short-Term Storage of the Alfalfa Pollinator, Megachile rotundata (Hymenoptera: Megachilidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Interrupting the spring incubation with short-term low-temperature storage of the developing pupae and pharate adult stage of Megachile rotundata (F.) is a useful technique for synchronizing the emergence of these bees with the peak alfalfa bloom. However, low-temperature exposure can be stressful d...

  9. 75 FR 62420 - In the Matter of: Certain Ground Fault Circuit Interrupters and Products Containing Same; Notice...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... From the Federal Register Online via the Government Publishing Office ] INTERNATIONAL TRADE COMMISSION In the Matter of: Certain Ground Fault Circuit Interrupters and Products Containing Same; Notice... that information on this matter can be obtained by contacting the Commission's TDD terminal on...

  10. Interruptible service system: A demand-side management application for the City of Los Angeles Department of Water & Power

    SciTech Connect

    Leblanc, M.; Sweeney, D.

    1994-12-31

    The Los Angeles Department of Water & Power (LADWP) instituted an electric rate schedule, A3-B, for its largest industrial power consumers in 1985. The A3 rate provides these LADWP customers (2000 Kilowatts or more users) a significant savings on their electric service rate. LADWP benefits by having the capability to interrupt the industrial customer`s load after giving them a 10 minute warning notice of interruption. The Interruptible Service System (ISS) automates this formerly manual process and allows for continuous monitoring of the power used of the power system`s largest power consumers. An ISS remote terminal unit (RTU) is installed at each customer`s site. This RTU communicates with a master computer (desktop PC) at LADWP`s Energy Control Center (ECC). The ECC initiates control, monitoring, and interrupt operations involving all customers on the ISS rate. Communication between the master computer and the various ISS customer RTUs will be accomplished via Pacific Bell Telephone`s advanced digital network (ADN). Future Plans include expansion to monitoring and control of co-generation facilities and monitoring of other large industrial customer power consumption.

  11. Critical finger ischemia and myocardial fibrosis development after sudden interruption of sildenafil treatment in a systemic sclerosis patient.

    PubMed

    Bruni, C; Bellando-Randone, S; Gargani, L; Picano, E; Pingitore, A; Matucci-Cerinic, M; Guiducci, S

    2016-01-01

    Systemic sclerosis (SSc) is a connective tissue disease frequently associated with Raynaud's Phenomenon (RP). Among possible pharmacological treatments, phosphodiesterase 5 inhibitors are considered in cases of severe non -responsive RP. We present the case of a male SSc patient wh presented with critical finger ischemia and concomitant appearance of myocardial fibrosis after sudden interruption of sildenafil treatment. PMID:27608801

  12. Examining the Internal Validity and Statistical Precision of the Comparative Interrupted Time Series Design by Comparison with a Randomized Experiment

    ERIC Educational Resources Information Center

    St.Clair, Travis; Cook, Thomas D.; Hallberg, Kelly

    2014-01-01

    Although evaluators often use an interrupted time series (ITS) design to test hypotheses about program effects, there are few empirical tests of the design's validity. We take a randomized experiment on an educational topic and compare its effects to those from a comparative ITS (CITS) design that uses the same treatment group as the…

  13. Measuring the Impacts of Community Development Initiatives: A New Application of the Adjusted Interrupted Time-Series Method

    ERIC Educational Resources Information Center

    Galster, George; Temkin, Kenneth; Walker, Chris; Sawyer, Noah

    2004-01-01

    The authors contribute to the development of empirical methods for measuring the impacts of place-based local development strategies by introducing the adjusted interrupted time-series (AITS) approach. It estimates a more precise counterfactual scenario, thus offering a stronger basis for drawing causal inferences about impacts. The authors…

  14. Exploring Relationships between Teachers' Philosophical Beliefs and Practices Relative to Unforeseen Interruptions in Elementary Classroom Instruction

    ERIC Educational Resources Information Center

    Mays, Faye Jeanette

    2012-01-01

    Teachers' knowledge, goals, beliefs, and decision-making activities were explored individually and combined relative to their philosophical beliefs and practices in the elementary classroom setting in response to unforeseen interruptions. Schoenfeld's Theory of Teaching-in-Context and Brown's "The Experimental Mind in…

  15. Reframing the Conversation about Students with Limited or Interrupted Formal Education: From Achievement Gap to Cultural Dissonance

    ERIC Educational Resources Information Center

    DeCapua, Andrea; Marshall, Helaine W.

    2015-01-01

    U.S. schools face increasing pressure to ensure that all students succeed, yet the dropout rate for English learners is alarmingly high, especially for those with limited or interrupted formal schooling (SLIFE). Serving SLIFE can be challenging because they not only need to master language and content but also need to develop literacy skills and…

  16. When Interrupted Intervention Leads to Failure: A Correlation Study of the Three-Tiered Reading Model in Grades K-2

    ERIC Educational Resources Information Center

    Weis, Beverly Lynn

    2012-01-01

    The three-tiered reading model is a widely practiced instructional scheme that moves students in and out of reading intervention groups during the school year. Though designed to treat students who need extra help learning to read, this interruption of reading interventions may hinder some students' progress. The purpose of this study was to…

  17. 18 CFR 260.9 - Reports by natural gas pipeline companies on service interruptions and damage to facilities.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Reports by natural gas..., NATURAL GAS ACT STATEMENTS AND REPORTS (SCHEDULES) § 260.9 Reports by natural gas pipeline companies on service interruptions and damage to facilities. (a)(1) Every natural gas company must report to...

  18. 18 CFR 260.9 - Reports by natural gas pipeline companies on service interruptions and damage to facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Reports by natural gas..., NATURAL GAS ACT STATEMENTS AND REPORTS (SCHEDULES) § 260.9 Reports by natural gas pipeline companies on service interruptions and damage to facilities. (a)(1) Every natural gas company must report to...

  19. 18 CFR 260.9 - Reports by natural gas pipeline companies on service interruptions and damage to facilities.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Reports by natural gas..., NATURAL GAS ACT STATEMENTS AND REPORTS (SCHEDULES) § 260.9 Reports by natural gas pipeline companies on service interruptions and damage to facilities. (a)(1) Every natural gas company must report to...

  20. Paying the price works: increasing goal-state access cost improves problem solving and mitigates the effect of interruption.

    PubMed

    Morgan, Phillip L; Patrick, John

    2013-01-01

    The aim of this paper was to investigate whether it was possible to induce more internal planning in the four-disk Tower of Hanoi (ToH) in order not only to produce more efficient problem solving but also to make it more resistant to the negative effect of interruption. The theoretical frameworks of soft constraints and the memory for goals model underpinned Experiments 1 and 2. In both experiments, three goal-state access cost conditions were used: high (mouse movements and 2.5-s delay), medium (mouse movements) and low (goal state always available). In Experiment 1, more memory-based planning was induced by the high cost condition, which resulted in fewer moves to solution and the gradual development of an efficient subgoaling strategy, resulting in more perfect solutions. In Experiment 2, the same condition protected performance against a 10-s interruption irrespective of the interrupting task (blank screen, mental arithmetic, or three-disk ToH). The more memory-based planning strategy, induced by high access cost, presumably strengthened participants' goals during planning and problem solving, making them less susceptible to decay and interference from interruption. These novel results are discussed in the context of other recent studies. PMID:22928975

  1. Use of Transnational Services to Prevent Treatment Interruption in Tuberculosis-Infected Persons Who Leave the United States

    PubMed Central

    Garnick, Deborah W.; Zuroweste, Edward; Razavi, Moaven; Shepard, Donald S.

    2016-01-01

    A major problem resulting from interrupted tuberculosis (TB) treatment is the development of drug-resistant TB, including multidrug-resistant TB (MDR TB), a more deadly and costly-to-treat form of the disease. Global health systems are not equipped to diagnose and treat the current burden of MDR TB. TB-infected foreign visitors and temporary US residents who leave the country during treatment can experience treatment interruption and, thus, are at greater risk for drug-resistant TB. Using epidemiologic and demographic data, we estimated TB incidence among this group, as well as the proportion of patients referred to transnational care–continuity and management services during relocation; each year, ≈2,827 visitors and temporary residents are at risk for TB treatment interruption, 222 (8%) of whom are referred for transnational services. Scale up of transnational services for persons at high risk for treatment interruption is possible and encouraged because of potential health gains and reductions in healthcare costs for the United States and receiving countries. PMID:26886720

  2. The Validity and Precision of the Comparative Interrupted Time-Series Design: Three Within-Study Comparisons

    ERIC Educational Resources Information Center

    St. Clair, Travis; Hallberg, Kelly; Cook, Thomas D.

    2016-01-01

    We explore the conditions under which short, comparative interrupted time-series (CITS) designs represent valid alternatives to randomized experiments in educational evaluations. To do so, we conduct three within-study comparisons, each of which uses a unique data set to test the validity of the CITS design by comparing its causal estimates to…

  3. Microsatellite Interruptions Stabilize Primate Genomes and Exist as Population-Specific Single Nucleotide Polymorphisms within Individual Human Genomes

    PubMed Central

    Ananda, Guruprasad; Hile, Suzanne E.; Breski, Amanda; Wang, Yanli; Kelkar, Yogeshwar; Makova, Kateryna D.; Eckert, Kristin A.

    2014-01-01

    Interruptions of microsatellite sequences impact genome evolution and can alter disease manifestation. However, human polymorphism levels at interrupted microsatellites (iMSs) are not known at a genome-wide scale, and the pathways for gaining interruptions are poorly understood. Using the 1000 Genomes Phase-1 variant call set, we interrogated mono-, di-, tri-, and tetranucleotide repeats up to 10 units in length. We detected ∼26,000–40,000 iMSs within each of four human population groups (African, European, East Asian, and American). We identified population-specific iMSs within exonic regions, and discovered that known disease-associated iMSs contain alleles present at differing frequencies among the populations. By analyzing longer microsatellites in primate genomes, we demonstrate that single interruptions result in a genome-wide average two- to six-fold reduction in microsatellite mutability, as compared with perfect microsatellites. Centrally located interruptions lowered mutability dramatically, by two to three orders of magnitude. Using a biochemical approach, we tested directly whether the mutability of a specific iMS is lower because of decreased DNA polymerase strand slippage errors. Modeling the adenomatous polyposis coli tumor suppressor gene sequence, we observed that a single base substitution interruption reduced strand slippage error rates five- to 50-fold, relative to a perfect repeat, during synthesis by DNA polymerases α, β, or η. Computationally, we demonstrate that iMSs arise primarily by base substitution mutations within individual human genomes. Our biochemical survey of human DNA polymerase α, β, δ, κ, and η error rates within certain microsatellites suggests that interruptions are created most frequently by low fidelity polymerases. Our combined computational and biochemical results demonstrate that iMSs are abundant in human genomes and are sources of population-specific genetic variation that may affect genome stability. The

  4. Role of contact tracing and prevention strategies in the interruption of leprosy transmission.

    PubMed

    Smith, W Cairns S; Aerts, Ann

    2014-03-01

    The global prevalence of leprosy has declined from 5.2 million in the 1980 s to 200,000 today. However, the new case detection rate remains high: over the last 8 years, around 220,000-250,000 people have been diagnosed with leprosy each year. In June 2013, an international meeting was organised by the Novartis Foundation for Sustainable Development in Geneva, Switzerland,2 with the objective of discussing the feasibility of interrupting the transmission of leprosy. The group of physicians, epidemiologists and public health professionals concluded that a successful programme would require early diagnosis and prompt multidrug therapy (MDT) for all patients, tracing and post-exposure prophylaxis (PEP) for contacts of patients newly diagnosed with leprosy, improvements in diagnostic tools, as well as strict epidemiological surveillance and response systems to monitor progress. As a follow-up, a second expert group meeting was convened by the Novartis Foundation in January 2014 in Zurich, Switzerland, with the objective of reviewing the evidence for chemoprophylaxis in contacts and high-risk communities. The meeting also considered the definitions of 'contacts' and 'contact tracing', discussed alternative prophylaxis regimens, preliminary findings of operational pilot projects on PEP in Indonesia, as well as the development of diagnostic tools, and identified the priority questions for operational research in leprosy transmission. The meeting outlined how contact tracing and chemoprophylaxis programmes can be implemented to interrupt leprosy transmission. The expert panel reached the following conclusions: Chemoprophylaxis with single-dose rifampicin (SDR) is efficacious in reducing the risk of developing leprosy, although the protective effect appears to be smaller in contacts closer to the index patient than in more distant contacts.3 SDR can be targeted to contacts or implemented as community mass prophylaxis in certain circumstances; the preferred approach depends

  5. Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review

    PubMed Central

    Del Mar, Chris; Dooley, Liz; Ferroni, Eliana; Al-Ansary, Lubna A; Bawazeer, Ghada A; van Driel, Mieke L; Foxlee, Ruth; Rivetti, Alessandro

    2009-01-01

    Objective To review systematically the evidence of effectiveness of physical interventions to interrupt or reduce the spread of respiratory viruses. Data sources Cochrane Library, Medline, OldMedline, Embase, and CINAHL, without restrictions on language or publication. Data selection Studies of any intervention to prevent the transmission of respiratory viruses (isolation, quarantine, social distancing, barriers, personal protection, and hygiene). A search of study designs included randomised trials, cohort, case-control, crossover, before and after, and time series studies. After scanning of the titles, abstracts and full text articles as a first filter, a standardised form was used to assess the eligibility of the remainder. Risk of bias of randomised studies was assessed for generation of the allocation sequence, allocation concealment, blinding, and follow-up. Non-randomised studies were assessed for the presence of potential confounders and classified as being at low, medium, or high risk of bias. Data synthesis 58 papers of 59 studies were included. The quality of the studies was poor for all four randomised controlled trials and most cluster randomised controlled trials; the observational studies were of mixed quality. Meta-analysis of six case-control studies suggested that physical measures are highly effective in preventing the spread of severe acute respiratory syndrome: handwashing more than 10 times daily (odds ratio 0.45, 95% confidence interval 0.36 to 0.57; number needed to treat=4, 95% confidence interval 3.65 to 5.52), wearing masks (0.32, 0.25 to 0.40; NNT=6, 4.54 to 8.03), wearing N95 masks (0.09, 0.03 to 0.30; NNT=3, 2.37 to 4.06), wearing gloves (0.43, 0.29 to 0.65; NNT=5, 4.15 to 15.41), wearing gowns (0.23, 0.14 to 0.37; NNT=5, 3.37 to 7.12), and handwashing, masks, gloves, and gowns combined (0.09, 0.02 to 0.35; NNT=3, 2.66 to 4.97). The combination was also effective in interrupting the spread of influenza within households. The highest

  6. Typed Versus Voice Recognition for Data Entry in Electronic Health Records: Emergency Physician Time Use and Interruptions

    PubMed Central

    dela Cruz, Jonathan E.; Shabosky, John C.; Albrecht, Matthew; Clark, Ted R.; Milbrandt, Joseph C.; Markwell, Steven J.; Kegg, Jason A.

    2014-01-01

    Introduction Use of electronic health record (EHR) systems can place a considerable data entry burden upon the emergency department (ED) physician. Voice recognition data entry has been proposed as one mechanism to mitigate some of this burden; however, no reports are available specifically comparing emergency physician (EP) time use or number of interruptions between typed and voice recognition data entry-based EHRs. We designed this study to compare physician time use and interruptions between an EHR system using typed data entry versus an EHR with voice recognition. Methods We collected prospective observational data at 2 academic teaching hospital EDs, one using an EHR with typed data entry and the other with voice recognition capabilities. Independent raters observed EP activities during regular shifts. Tasks each physician performed were noted and logged in 30 second intervals. We compared time allocated to charting, direct patient care, and change in tasks leading to interruptions between sites. Results We logged 4,140 minutes of observation for this study. We detected no statistically significant differences in the time spent by EPs charting (29.4% typed; 27.5% voice) or the time allocated to direct patient care (30.7%; 30.8%). Significantly more interruptions per hour were seen with typed data entry versus voice recognition data entry (5.33 vs. 3.47; p=0.0165). Conclusion The use of a voice recognition data entry system versus typed data entry did not appear to alter the amount of time physicians spend charting or performing direct patient care in an ED setting. However, we did observe a lower number of workflow interruptions with the voice recognition data entry EHR. Additional research is needed to further evaluate the data entry burden in the ED and examine alternative mechanisms for chart entry as EHR systems continue to evolve. PMID:25035765

  7. Scottish Keep Well health check programme: an interrupted time series analysis

    PubMed Central

    Geue, Claudia; Lewsey, James D; MacKay, Daniel F; Antony, Grace; Fischbacher, Colin M; Muirie, Jill; McCartney, Gerard

    2016-01-01

    Background Effective interventions are available to reduce cardiovascular risk. Recently, health check programmes have been implemented to target those at high risk of cardiovascular disease (CVD), but there is much debate whether these are likely to be effective at population level. This paper evaluates the impact of wave 1 of Keep Well, a Scottish health check programme, on cardiovascular outcomes. Methods Interrupted time series analyses were employed, comparing trends in outcomes in participating and non-participating practices before and after the introduction of health checks. Health outcomes are defined as CVD mortality, incident hospitalisations and prescribing of cardiovascular drugs. Results After accounting for secular trends and seasonal variation, coronary heart disease mortality and hospitalisations changed by 0.4% (95% CI −5.2% to 6.3%) and −1.1% (−3.4% to 1.3%) in Keep Well practices and by −0.3% (−2.7% to 2.2%) and −0.1% (−1.8% to 1.7%) in non-Keep Well practices, respectively, following the intervention. Adjusted changes in prescribing in Keep Well and non-Keep Well practices were 0.4% (−10.4% to 12.5%) and −1.5% (−9.4% to 7.2%) for statins; −2.5% (−12.3% to 8.4%) and −1.6% (−7.1% to 4.3%) for antihypertensive drugs; and −0.9% (−6.5% to 5.0%) and −2.4% (−10.1% to 6.0%) for antiplatelet drugs. Conclusions Any impact of the Keep Well health check intervention on CVD outcomes and prescribing in Scotland was very small. Findings do not support the use of the screening approach used by current health check programmes to address CVD. We used an interrupted time series method, but evaluation methods based on randomisation are feasible and preferable and would have allowed more reliable conclusions. These should be considered more often by policymakers at an early stage in programme design when there is uncertainty regarding programme effectiveness. PMID:27072868

  8. Single-Layer Continuous Versus Two-Layer Interrupted Intestinal Anastomosis

    PubMed Central

    Burch, Jon M.; Franciose, Reginald J.; Moore, Ernest E.; Biffl, Walter L.; Offner, Patrick J.

    2000-01-01

    Objective To determine the suitability of a single-layer continuous technique for intestinal anastomosis in a surgical training program. Summary Background Data Several recent reports have advocated the use of a continuous single-layer technique for intestinal anastomosis. Purported advantages include shorter time for construction, lower cost, and perhaps a lower rate of anastomotic leakage. The authors hypothesized that the single-layer continuous anastomosis could be safely introduced into a surgical training program and that it could be performed in less time and at a lower cost than the two-layer interrupted anastomosis. Methods The study was conducted during a 3-year period ending September 1999. All adult patients requiring intestinal anastomosis were considered eligible. Patients who required anastomosis to the stomach, duodenum, and rectum were excluded. Patients were also excluded if the surgeon did not believe either technique could be used. Patients were randomly assigned to one- or two-layer techniques. Single-layer anastomoses were performed with a continuous 3–0 polypropylene suture. Two-layer anastomoses were constructed using interrupted 3–0 silk Lembert sutures for the outer layer and a continuous 3–0 polyglycolic acid suture for the inner layer. The time for anastomosis began with the placement of the first stitch and ended when the last stitch was cut. Anastomotic leak was defined as radiographic demonstration of a fistula or nonabsorbable material draining from a wound after oral administration, or visible disruption of the suture line during reexploration. Results Sixty-five single-layer and 67 two-layer anastomoses were performed. The groups were evenly matched according to age, sex, diagnosis, and location of the anastomosis. Two leaks (3.1%) occurred in the single-layer group and one (1.5%) in the two-layer group. Two abscesses (3.0%) occurred in each group. A mean of 20.8 minutes was required to construct a single-layer anastomosis

  9. Formation, Redox-Controled Preservation, and Interruption of Organic-rich Sapropel S1 sediments

    NASA Astrophysics Data System (ADS)

    De Lange, Gert J.; Hennekam, Rick; Goudeau, Marie-Louise; Filippidi, Amalia

    2015-04-01

    Distinct, organic-rich units (sapropels) occur in Mediterraneran sediments in a repetitive, climate-controled way. Their deposition is thought to be precession-related and to be associated with humid climate conditions. The last humid period from 11 - 5 kyr 14C ago, occurred simultaneous with a sustained circum-Mediterranean wet period. Within that period, the most recent sapropel (S1) formed synchronously between 9.8 and 5.7 14C ky BP at all water depths greater than a few hundred metres. As a consequence of increased fresh water (monsoon) input, surface waters had a reduced salinity and concomitantly the deep (> 1.8 km) eastern Mediterranean Sea was devoid of oxygen during 4,000 years of S1. This has resulted in a differential basin-wide preservation of S1 determined by water depth, as a result of different ventilation/climate-related redox conditions above and below 1.8 km. The end of this period is marked by a basin-wide high sedimentary manganese-oxide peak that represents an abrupt re-ventilation of the deep-water at 5.7 kyr. The sustaining oxic conditions thereafter have resulted in a downward progressing oxidation-front that is not only characterized by the degradation of most organic matter over its active pathway, but also by the built-up of manganese oxide. The latter has resulted in a secondary Mn-peak below the first, upper, ventilation Mn-peak. Apart from the major re-ventilation event at the end of sapropel S1 formation, also other, short-term ventilation events appear to have occurred during its formation, notably the 8.2 ka event. This potentially basin-wide event is particularly noticeable at relatively shallow near-coastal sites of high sedimentation rates. It marks a brief episode of not only re-oxygenated deep water thus reduced preservation, but also decreased primary productivity thus nutrient supply. This 8.2 cal ka BP interruption event is thought to be related to enhanced deep water formation in the Aegean or Adriatic due to a period of

  10. Redox-Controled Preservation of Mediterranean Sapropel S1 deposits during Formation and Interruption

    NASA Astrophysics Data System (ADS)

    De Lange, Gert J.; Filippidi, Amalia; Goudeau, Marie-Louise; Hennekam, Rick

    2016-04-01

    Organic-rich units (sapropels) occur in Mediterraneran sediments in a repetitive, climate-controled way. Their deposition is thought to be precession-related and to be associated with humid climate conditions. The last humid period from 11 - 5 kyr 14C ago, occurred simultaneous with a sustained circum-Mediterranean wet period and vegetated Sahara. Within that period, the most recent sapropel (S1) formed synchronously between 9.8 and 5.7 14C ky BP at all water depths greater than a few hundred metres. As a consequence of increased fresh water (monsoon) input, surface waters had a reduced salinity and concomitantly the deep (> 1.8 km) eastern Mediterranean Sea was devoid of oxygen during 4,000 years of S1 formation. This has resulted in a differential basin-wide preservation of S1sediments determined by water depth, as a result of different ventilation/climate-related redox conditions above and below 1.8 km. The end of this period is marked by a basin-wide high sedimentary manganese-oxide peak that represents an abrupt re-ventilation of the deep-water at 5.7 kyr. The sustaining oxic conditions thereafter have resulted in a downward progressing oxidation-front that is not only characterized by the degradation of most organic matter over its active pathway, but also by the built-up of manganese oxide. The latter has resulted in a secondary diagenetic Mn-peak below the first, upper, ventilation Mn-peak. Apart from the major re-ventilation event at the end of sapropel S1 formation, also other, short-term ventilation events appear to have occurred during its formation, notably during the 8.2 ka event. This potentially basin-wide event is particularly noticeable at relatively shallow near-coastal sites of high sedimentation rates. It marks a brief episode of not only re-oxygenated deep water thus reduced preservation, but also decreased primary productivity thus nutrient supply. This 8.2 cal ka BP interruption event is thought to be related to enhanced deep water formation

  11. Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review

    PubMed Central

    2008-01-01

    Objective To systematically review evidence for the effectiveness of physical interventions to interrupt or reduce the spread of respiratory viruses. Data extraction Search strategy of the Cochrane Library, Medline, OldMedline, Embase, and CINAHL, without language restriction, for any intervention to prevent transmission of respiratory viruses (isolation, quarantine, social distancing, barriers, personal protection, and hygiene). Study designs were randomised trials, cohort studies, case-control studies, and controlled before and after studies. Data synthesis Of 2300 titles scanned 138 full papers were retrieved, including 49 papers of 51 studies. Study quality was poor for the three randomised controlled trials and most of the cluster randomised controlled trials; the observational studies were of mixed quality. Heterogeneity precluded meta-analysis of most data except that from six case-control studies. The highest quality cluster randomised trials suggest that the spread of respiratory viruses into the community can be prevented by intervening with hygienic measures aimed at younger children. Meta-analysis of six case-control studies suggests that physical measures are highly effective in preventing the spread of SARS: handwashing more than 10 times daily (odds ratio 0.45, 95% confidence interval 0.36 to 0.57; number needed to treat=4, 95% confidence interval 3.65 to 5.52); wearing masks (0.32, 0.25 to 0.40; NNT=6, 4.54 to 8.03); wearing N95 masks (0.09, 0.03 to 0.30; NNT=3, 2.37 to 4.06); wearing gloves (0.43, 0.29 to 0.65; NNT=5, 4.15 to 15.41); wearing gowns (0.23, 0.14 to 0.37; NNT=5, 3.37 to 7.12); and handwashing, masks, gloves, and gowns combined (0.09, 0.02 to 0.35; NNT=3, 2.66 to 4.97). The incremental effect of adding virucidals or antiseptics to normal handwashing to decrease the spread of respiratory disease remains uncertain. The lack of proper evaluation of global measures such as screening at entry ports and social distancing prevent firm

  12. Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials.

    PubMed

    Bergouignan, Audrey; Latouche, Celine; Heywood, Sarah; Grace, Megan S; Reddy-Luthmoodoo, Medini; Natoli, Alaina K; Owen, Neville; Dunstan, David W; Kingwell, Bronwyn A

    2016-01-01

    Epidemiological studies have observed associations between frequent interruptions of sitting time with physical activity bouts and beneficial metabolic outcomes, even in individuals who regularly exercise. Frequent interruptions to prolonged sitting reduce postprandial plasma glucose. Here we studied potential skeletal muscle mechanisms accounting for this improved control of glycemia in overweight adults under conditions of one day uninterrupted sitting and sitting interrupted with light-intensity or moderate-intensity walking every 20-min (n = 8); and, after three days of either uninterrupted sitting or light-intensity walking interruptions (n = 5). Contraction- and insulin-mediated glucose uptake signaling pathways as well as changes in oxidative phosphorylation proteins were examined. We showed that 1) both interventions reduce postprandial glucose concentration, 2) acute interruptions to sitting over one day stimulate the contraction-mediated glucose uptake pathway, 3) both acute interruptions to sitting with moderate-intensity activity over one day and light-intensity activity over three days induce a transition to modulation of the insulin-signaling pathway, in association with increased capacity for glucose transport. Only the moderate-intensity interruptions resulted in greater capacity for glycogen synthesis and likely for ATP production. These observations contribute to a mechanistic explanation of improved postprandial glucose metabolism with regular interruptions to sitting time, a promising preventive strategy for metabolic diseases. PMID:27554943

  13. Protective Factors Interrupting the Continuity from School Bullying to Later Internalizing and Externalizing Problems: A Systematic Review of Prospective Longitudinal Studies

    ERIC Educational Resources Information Center

    Ttofi, Maria M.; Bowes, Lucy; Farrington, David P.; Lösel, Friedrich

    2014-01-01

    A systematic review is presented, based on prospective longitudinal studies, on protective factors that interrupt the continuity from bullying perpetration at school to externalizing problem behaviors later in life; and from bullying victimization to later internalizing problems. Some common factors were established, which seem to interrupt the…

  14. Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials

    PubMed Central

    Bergouignan, Audrey; Latouche, Celine; Heywood, Sarah; Grace, Megan S.; Reddy-Luthmoodoo, Medini; Natoli, Alaina K.; Owen, Neville; Dunstan, David W.; Kingwell, Bronwyn A.

    2016-01-01

    Epidemiological studies have observed associations between frequent interruptions of sitting time with physical activity bouts and beneficial metabolic outcomes, even in individuals who regularly exercise. Frequent interruptions to prolonged sitting reduce postprandial plasma glucose. Here we studied potential skeletal muscle mechanisms accounting for this improved control of glycemia in overweight adults under conditions of one day uninterrupted sitting and sitting interrupted with light-intensity or moderate-intensity walking every 20-min (n = 8); and, after three days of either uninterrupted sitting or light-intensity walking interruptions (n = 5). Contraction- and insulin-mediated glucose uptake signaling pathways as well as changes in oxidative phosphorylation proteins were examined. We showed that 1) both interventions reduce postprandial glucose concentration, 2) acute interruptions to sitting over one day stimulate the contraction-mediated glucose uptake pathway, 3) both acute interruptions to sitting with moderate-intensity activity over one day and light-intensity activity over three days induce a transition to modulation of the insulin-signaling pathway, in association with increased capacity for glucose transport. Only the moderate-intensity interruptions resulted in greater capacity for glycogen synthesis and likely for ATP production. These observations contribute to a mechanistic explanation of improved postprandial glucose metabolism with regular interruptions to sitting time, a promising preventive strategy for metabolic diseases. PMID:27554943

  15. Caring Is Not Enough: Teachers' Enactment of Ethical Care for Adolescent Students with Limited or Interrupted Formal Education (SLIFE) in a Newcomer Classroom

    ERIC Educational Resources Information Center

    Hos, Rabia

    2016-01-01

    The educational landscape for schools in the United States is continuing to shift with the arrival of refugee students with limited or interrupted formal education, especially at the secondary schools. As refugee students with limited or interrupted formal education (SLIFE) adjust to schools in the United States, they may experience acculturative…

  16. Effectiveness of an improved road safety policy in Ethiopia: an interrupted time series study

    PubMed Central

    2014-01-01

    Background In recent years, there has been an increasing interest in implementing road safety policy by different low income countries. However; the evidence is scarce on its success in the reduction of crashes, injuries and deaths. This study was conducted to assess whether road crashes, injuries and fatalities was reduced following the road safety regulation introduced as of September 2007 by Oromia Regional State Transport Bureau. Methods Routine road traffic accident data for the year 2002-2011were collected from sixteen traffic police offices. Data on average daily vehicle flow was obtained from the Ethiopian Road Authority. Interrupted time series design using segmented linear regression model was applied to estimate the effect of an improved road safety policy. Results A total of 4,053 crashes occurred on Addis Ababa - Adama/Hawassa main road. Of these crashes, almost half 46.4% (1,880) were property damage, 29.4% (1,193) were fatal and 24.2% (980) injury crashes, resulting 1,392 fatalities and 1,749 injuries. There were statistically significant reductions in non-injury crashes and deaths. Non-injury crash was reduced by 19% and fatality by 12.4% in the first year of implementing the revised transport safety regulation. Conclusion Although revised road safety policy helped in reducing motor vehicle crashes and associated fatalities, the overall incidence rate is still very high. Further action is required to avoid unnecessary loss of lives. PMID:24886220

  17. Framework for evaluating the risks of paralytic poliomyelitis after global interruption of wild poliovirus transmission.

    PubMed Central

    Aylward, R. Bruce; Cochi, Stephen L.

    2004-01-01

    With the interruption of wild poliovirus transmission globally, the need for new policies to deal with the post-certification era will rapidly arise. New policies will be required in four areas: detection and notification of circulating polioviruses; biocontainment of wild, vaccine-derived and attenuated strains of poliovirus; vaccine stockpiles and response mechanisms; and routine immunization against polioviruses. A common understanding of the potential risks of paralytic poliomyelitis in the post-certification period is essential to the development of these policies. Since 2000, there has been increasing international consensus that the risks of paralytic poliomyelitis in the post-certification era fall into two categories: those due to the continued use of the oral poliovirus vaccine (OPV) and those due to future improper handling of wild polioviruses. The specific risks within both categories have now been defined, and an understanding of the frequency and potential burden of disease associated with each is rapidly improving. This knowledge and clarity have provided a framework that is already proving valuable for identifying research priorities and discussing potential policy options with national authorities. However, this framework must be regarded as a dynamic tool, requiring regular updating as additional information on these risks becomes available through further scientific research, programmatic work, and policy decisions. PMID:15106299

  18. Interrupted and Isothermal Solidification Studies of Low and Medium Carbon Steels

    NASA Astrophysics Data System (ADS)

    Pottore, N. S.; Garcia, C. I.; Deardo, A. J.

    1991-08-01

    Low and medium carbon steels experience multiple phase transformations during solidification and subsequent cooling. The sequence, extent, and nature of the different transformations have a significant bearing on the microstructural evolution that occurs in the steel. The change in microstructure with temperature is very important, since it may influence the hot ductility of the steel during casting and/or rolling and the subsequent response of the material to thermoprocessing. The aim of this investigation was to gain a better understanding of the development of the as-cast structure in low and medium carbon steels. Of particular interest is the origin of the large austenite grains frequently associated with poor hot ductility. Interrupted and isothermal solidification experiments were therefore conducted to study the nonequilibrium and near-equilibrium structures which form at different stages of the freezing process. The results of the investigation established delta-ferrite as the primary solidifying phase in low carbon steels. Austenite forms as the secondary phase by nucleation at the solidification (delta-ferrite) boundaries. While excessive austenite grain coarsening is suppressed by the coexistence of the second phases delta-ferrite or liquid, this suppression occurs over only a limited temperature range, just below the peritectic temperature. Subsequent cooling leads to very large austenite grains, ranging up to 5 mm in diameter, in steels of low carbon content.

  19. Cessation of Mass Drug Administration for Lymphatic Filariasis in Zanzibar in 2006: Was Transmission Interrupted?

    PubMed Central

    Rebollo, Maria P.; Mohammed, Khalfan A.; Thomas, Brent; Ame, Shaali; Ali, Said Mohammed; Cano, Jorge; Escalada, Alba Gonzalez; Bockarie, Moses J.

    2015-01-01

    Background Lymphatic filariasis (LF) is targeted for elimination through annual mass drug administration (MDA) for 4–6 years. In 2006, Zanzibar stopped MDA against LF after five rounds of MDA revealed no microfilaraemic individuals during surveys at selected sentinel sites. We asked the question if LF transmission was truly interrupted in 2006 when MDA was stopped. Methodology/Principal Findings In line with ongoing efforts to shrink the LF map, we performed the WHO recommended transmission assessment surveys (TAS) in January 2012 to verify the absence of LF transmission on the main Zanzibar islands of Unguja and Pemba. Altogether, 3275 children were tested on both islands and 89 were found to be CFA positive; 70 in Pemba and 19 in Unguja. The distribution of schools with positive children was heterogeneous with pronounced spatial variation on both islands. Based on the calculated TAS cut-offs of 18 and 20 CFA positive children for Pemba and Unguja respectively, we demonstrated that transmission was still ongoing in Pemba where the cut-off was exceeded. Conclusions Our findings indicated ongoing transmission of LF on Pemba in 2012. Moreover, we presented evidence from previous studies that LF transmission was also active on Unguja shortly after stopping MDA in 2006. Based on these observations the government of Zanzibar decided to resume MDA against LF on both islands in 2013. PMID:25816287

  20. Polymethylene-interrupted fatty acids: Biomarkers for native and exotic mussels in the Laurentian Great Lakes

    USGS Publications Warehouse

    Mezek, Tadej; Sverko, Ed; Ruddy, Martina D.; Zaruk, Donna; Capretta, Alfredo; Hebert, Craig E.; Fisk, Aaron T.; McGoldrick, Daryl J.; Newton, Teresa J.; Sutton, Trent M.; Koops, Marten A.; Muir, Andrew M.; Johnson, Timothy B.; Ebener, Mark P.; Arts, Michael T.

    2011-01-01

    Freshwater organisms synthesize a wide variety of fatty acids (FAs); however, the ability to synthesize and/or subsequently modify a particular FA is not universal, making it possible to use certain FAs as biomarkers. Herein we document the occurrence of unusual FAs (polymethylene-interrupted fatty acids; PMI-FAs) in select freshwater organisms in the Laurentian Great Lakes. We did not detect PMI-FAs in: (a) natural seston from Lake Erie and Hamilton Harbor (Lake Ontario), (b) various species of laboratory-cultured algae including a green alga (Scenedesmus obliquus), two cyanobacteria (Aphanizomenon flos-aquae and Synechococystis sp.), two diatoms (Asterionella formosa, Diatoma elongatum) and a chrysophyte (Dinobryon cylindricum) or, (c) zooplankton (Daphnia spp., calanoid or cyclopoid copepods) from Lake Ontario, suggesting that PMI-FAs are not substantively incorporated into consumers at the phytoplankton–zooplankton interface. However, these unusual FAs comprised 4-6% of total fatty acids (on a dry tissue weight basis) of native fat mucket (Lampsilis siliquoidea) and plain pocketbook (L. cardium) mussels and in invasive zebra (Dreissena polymorpha) and quagga (D. bugensis) mussels. We were able to clearly partition Great Lakes' mussels into three separate groups (zebra, quagga, and native mussels) based solely on their PMI-FA profiles. We also provide evidence for the trophic transfer of PMI-FAs from mussels to various fishes in Lakes Ontario and Michigan, further underlining the potential usefulness of PMI-FAs for tracking the dietary contribution of mollusks in food web and contaminant-fate studies.

  1. Motivational priming and processing interrupt: startle reflex modulation during shallow and deep processing of emotional words.

    PubMed

    Herbert, Cornelia; Kissler, Johanna

    2010-05-01

    Valence-driven modulation of the startle reflex, that is larger eyeblinks during viewing of unpleasant pictures and inhibited blinks while viewing pleasant pictures, is well documented. The current study investigated, whether this motivational priming pattern also occurs during processing of unpleasant and pleasant words, and to what extent it is influenced by shallow vs. deep encoding of verbal stimuli. Emotional and neutral adjectives were presented for 5s, and the acoustically elicited startle eyeblink response was measured while subjects memorized the words by means of shallow or deep processing strategies. Results showed blink potentiation to unpleasant and blink inhibition to pleasant adjectives in subjects using shallow encoding strategies. In subjects using deep-encoding strategies, blinks were larger for pleasant than unpleasant or neutral adjectives. In line with this, free recall of pleasant words was also better in subjects who engaged in deep processing. The results suggest that motivational priming holds as long as processing is perceptual. However, during deep processing the startle reflex appears to represent a measure of "processing interrupt", facilitating blinks to those stimuli that are more deeply encoded. PMID:20171998

  2. Adherence to antiretroviral therapy and acceptability of planned treatment interruptions in HIV-infected children.

    PubMed

    Harrison, Linda; Ananworanich, Jintanat; Hamadache, Djamel; Compagnucci, Alexandra; Penazzato, Martina; Bunupuradah, Torsak; Mazza, Antonio; Ramos, Jose Tomas; Flynn, Jacquie; Rampon, Osvalda; Mellado Pena, Maria Jose; Floret, Daniel; Marczynska, Magdalena; Puga, Ana; Forcat, Silvia; Riault, Yoann; Lallemant, Marc; Castro, Hannah; Gibb, Diana M; Giaquinto, Carlo

    2013-01-01

    There have been no paediatric randomised trials describing the effect of planned treatment interruptions (PTIs) of antiretroviral therapy (ART) on adherence, or evaluating acceptability of such a strategy. In PENTA 11, HIV-infected children were randomised to CD4-guided PTIs (n = 53) or continuous therapy (CT, n = 56). Carers, and children if appropriate, completed questionnaires on adherence to ART and acceptability of PTIs. There was no difference in reported adherence on ART between CT and PTI groups; non-adherence (reporting missed doses over the last 3 days or marking <100 % adherence since the last clinical visit on a visual analogue scale) was 18 % (20/111) and 14 % (12/83) on carer questionnaires in the CT and PTI groups respectively (odds ratios, OR (95 % CI) = 1.04 (0.20, 5.41), χ(2) (1) = 0.003, p = 0.96). Carers in Europe/USA reported non-adherence more often (31/121, 26 %) than in Thailand (1/73, 1 %; OR (95 % CI) = 54.65 (3.68, 810.55), χ(2) (1) = 8.45, p = 0.004). The majority of families indicated they were happy to have further PTIs (carer: 23/36, 64 %; children: 8/13, 62 %), however many reported more clinic visits during PTI were a problem (carer: 15/36, 42 %; children: 6/12, 50 %). PMID:22584916

  3. [Study on the efficacy of genetically engineered vaccines against hepatitis B for interruption of perinatal transmission].

    PubMed

    Kang, P; Shen, X M; Yu, H M

    1995-07-01

    The infectivity rate of newborn babies who had been borne from HBsAG(+), HBeAg(+) and anti-HBc(+) mothers was very high (85%). 142 babies born in the hospital were divided into three groups, in this study. In the group 1, 57 babies were inoculated with 20 micrograms recombinant DNA vaccinia vaccines against hepatitis B. The injections were given at newborn, 1 month, and 6 months, respectively. In group 2, 41 babies were inoculated with 20 micrograms genetic engineering vaccines against hepatitis B at same time were intervals as group 1. In group 3, 44 newborn babies were inoculated with 10 micrograms as same vaccines as group 2 HBIG plus 1ml (200 U/ml), at same time intervals as group 1. The immune pretection rates of newborn babies in three groups were 88.2%, 85.9% and 100%, respectively. The anti-HBs pasitive conversion rates were 82%, 86% and 98%, respectively. The group 3 was compared with group 1 and 2. Statistical analysis showed the significant differences (P < 0.05). The result showed the immune program of group 3 was superior to that of group 1 and 2, and none of the 44 babies in group 3 were infected. The efficacy of immunization by genetic engineering vaccines were superior to that of blood-derived vaccine. The genetic engineering vaccines against hepatitis B would be more useful for interruption of perinatal transmission of HBV. PMID:8631089

  4. Application of padmounted fault interrupters to single-phase URD systems

    SciTech Connect

    Israel, W.F.

    1995-12-31

    Underground distribution has proven itself to be a highly effective means of eliminating the temporary faults that plague overhead distribution, however, the permanent faults that do occur are often cable or splice failures which are unpredictable, difficult to locate and require a lot of time and expense to repair. One of the ways that the designer seeks to minimize the impact of such events on service reliability is by incorporating an overcurrent protection scheme which removes the faulted section from the rest of the system and contingency scheme which allows isolation of the faulted section and restoration of service in the shortest possible time with a minimal number of switching operations. As a result there has been a continuing interest in the development of devices, equipment, and methods which help to realize the ideals of rapid service restoration and isolation of faults to the smallest segment of the system. Overcurrent protection of the single-phase URD system has, traditionally, been the province of fused cutouts and fused padmounted sectionalizing terminals and switchgear. Recently however, padmounted vacuum fault interrupters, that utilize electronic controls for tripping, have become available from several manufacturers and are beginning to make inroads into this portion of the distribution system. This paper will discuss the characteristics and potential applications of a new product offered by Cooper Power Systems, the Shrubline VFI, which was designed specifically for use in single phase residential underground distribution.

  5. [Modifications induced on thrombin and plasmin activity by voluntary interruption of pregnancy].

    PubMed

    Manoni, F; Gessoni, G; Antico, A; Finesso, P; Rossito, G; Sartori, R

    1993-05-01

    Pregnancy is characterized by plasmatic variations of coagulative factors' concentration and by different haemostatic-fibrinolytic balance. At present it is possible, with EIA methods, to measure fibrinogen (FgDP) and fibrin (FbDP) degradation products with precision and accuracy, as direct indexes of fibrinolysis and the thrombin-antithrombin III complex (TAT) as indirect index of thrombophilia. We have considered the course of those indexes in 61 pregnant women within the tenth week of gestation, before and after voluntary pregnancy interruption (VPI) resulted without complications. The results don't show any peculiar variation of the examined parameters between the pregnant women before VPI and a control group. Comparing the basal data with those obtained three hours after VPI, all indexes are increased, particularly FbDP. After 24 hours the concentration of FgDP, FbDP and TDP decreased in comparison with the three hours control drawing, nevertheless staying higher than the values obtained in the basal drawing. The evolution of FDP and of TAT, in our study, points out that, in the first weeks of pregnancy, the haemostatic-fibrinolytic balance does not differ significantly from the physiological balance. Three hours after VPI fibrinolytic mechanisms prevail as regards the fibrinogenolytic ones. TAT increases after 3 hours and returns to the rules after 24 hours, proposing itself as an indirect index of thrombinic activation and as a direct index of antithrombinic activity. PMID:8351063

  6. A LTR copia retrotransposon and Mutator transposons interrupt Pgip genes in cultivated and wild wheats.

    PubMed

    Di Giovanni, Michela; Cenci, Alberto; Janni, Michela; D'Ovidio, Renato

    2008-04-01

    Polygalacturonase-inhibiting proteins (PGIPs) are leucine-rich repeat (LRR) proteins involved in plant defence. Wheat pgip genes have been isolated from the B (Tapgip1) and D (Tapgip2) genomes, and now we report the identification of pgip genes from the A genomes of wild and cultivated wheats. By Southern blots and sequence analysis of BAC clones we demonstrated that wheat contains a single copy pgip gene per genome and the one from the A genome, pgip3, is inactivated by the insertion of a long terminal repeat copia retrotranspon within the fourth LRR. We demonstrated also that this retrotransposon insertion is present in Triticum urartu and all the polyploidy wheats assayed, but is absent in T. monococcum (Tmpgip3), suggesting that this insertion took place after the divergence between T. monococcum and T. urartu, but before the formation of the polyploid wheats. We identified also two independent insertion events of new Class II transposable elements, Vacuna, belonging to the Mutator superfamily, that interrupted the Tdipgip1 gene of T. turgidum ssp. dicoccoides. The occurrence of these transposons within the coding region of Tdipgip1 facilitated the mapping of the Pgip locus in the pericentric region of the short arm of chromosome group 7. We speculate that the inactivation of pgip genes are tolerated because of redundancy of PGIP activities in the wheat genome. PMID:18301877

  7. Contribution of Environmental Surveillance Toward Interruption of Poliovirus Transmission in Nigeria, 2012–2015

    PubMed Central

    Johnson Muluh, Ticha; Hamisu, Abdullahi Walla; Craig, Kehinde; Mkanda, Pascal; Andrew, Etsano; Adeniji, Johnson; Akande, Adefunke; Musa, Audu; Ayodeji, Isiaka; Nicksy, Gumede; Banda, Richard; Tegegne, Sisay G.; Nsubuga, Peter; Oyetunji, Ajiboye; Diop, Ousmane; Vaz, Rui G.; Muhammad, Ado J. G.

    2016-01-01

    Background. Cases of paralysis caused by poliovirus have decreased by >99% since the 1988 World Health Assembly's resolution to eradicate polio. The World Health Organization identified environmental surveillance (ES) of poliovirus in the poliomyelitis eradication strategic plan as an activity that can complement acute flaccid paralysis (AFP) surveillance. This article summarizes key public health interventions that followed the isolation of polioviruses from ES between 2012 and 2015. Methods. The grap method was used to collect 1.75 L of raw flowing sewage every 2–4 weeks. Once collected, samples were shipped at 4°C to a polio laboratory for concentration. ES data were then used to guide program implementation. Results. From 2012 to 2015, ES reported 97 circulating vaccine-derived polioviruses (cVDPV2) and 14 wild polioviruses. In 2014 alone, 54 cVDPV type 2 cases and 1 WPV type 1 case were reported. In Sokoto State, 58 cases of AFP were found from a search of 9426 households. A total of 2 252 059 inactivated polio vaccine and 2 460 124 oral polio vaccine doses were administered to children aged <5 year in Borno and Yobe states. Conclusions. This article is among the first from Africa that relates ES findings to key public health interventions (mass immunization campaigns, inactivated polio vaccine introduction, and strengthening of AFP surveillance) that have contributed to the interruption of poliovirus transmission in Nigeria. PMID:26908747

  8. Life interrupted and life regained? Coping with stroke at a young age

    PubMed Central

    Dow, Clare; Locock, Louise; Lyons, Renee F.; Lasserson, Daniel

    2014-01-01

    Stroke is a leading cause of disability across the developed world, affecting an increasing number of younger people. In this article, we seek to understand the experience of stroke as a disabling life situation among young people and the strategies that they use to recover and cope. Directed content analysis was conducted from interviews with 17 community-dwelling stroke survivors aged 55 years and younger across the United Kingdom. The sample was drawn from a larger maximum variation sample of stroke survivors. Using the sociological concepts of biographical disruption and biographical repair as a guide, excerpts from the interviews pertaining to aspects of the patients’ life that were interrupted, in addition to how they coped with the changes, were selected and analysed. All individuals described an “altered sense of self,” a theme that included loss of identity, family disruption, and/or loss of valued activities. Individuals sought to adapt their sense of self by seeking external support, by restoring normality, and/or through positive reflection. Despite the adapted self that emerged, most individuals continued to experience impairments. While young stroke survivors adapt to their illness over time, they continue to experience impairments and disruptions in their personal and work lives. A holistic model of rehabilitation that helps individuals regain the capacity for everyday activities related to work, family life, and leisure can begin to address the emotional ramifications of diseases such as stroke, restore wellness, and work towards minimizing the burden felt by family caregivers and children. PMID:24461569

  9. Non-hormonal interruption of incessant ovulation as a potential approach for ovarian cancer prevention.

    PubMed

    Fathalla, Mahmoud F

    2016-03-01

    Ovarian cancer is a silent killer. There is a need to intensify research efforts on prevention strategies. The causative role of incessant ovulation has been supported by the protective effect of oral hormonal contraceptives. The released follicular fluid in the process of ovulation bathes not only the surface of the ovary but also the fimbrial end of the fallopian tube. Evidence has been accumulating about a fimbrial tubal origin for ovarian high-grade serous carcinoma, and for the potential of opportunistic or elective salpingectomy as an intervention strategy. Alternatively, periodic suppression of ovulation could be beneficial among women who have no need or are not using oral hormonal contraceptives. Rupture of the ovarian follicle releasing the ovum and follicular fluid is a prostaglandin-mediated inflammatory process. It can be stopped by nonsteroidal anti-inflammatory drugs, leading to pharmacologic production of a luteinized unruptured follicle, simulating a normal non-conception cycle with unaltered steroid patterns/levels and cycle length. Non-hormonal periodic interruption of incessant ovulation could be recommended for women who are at high risk of ovarian cancer, but further research is needed to validate the potential of this approach. PMID:26876699

  10. Direct Observation of Intermediates Involved in the Interruption of the Bischler-Napieralski Reaction.

    PubMed

    White, Kolby L; Mewald, Marius; Movassaghi, Mohammad

    2015-08-01

    The first mechanistic investigation of electrophilic amide activation of α,α-disubstituted tertiary lactams and the direct observation of key intermediates by in situ FTIR, (1)H, (13)C, and (19)F NMR in our interrupted Bischler-Napieralski-based synthetic strategy to the aspidosperma alkaloids, including a complex tetracyclic diiminium ion, is discussed. The reactivity of a wide range of pyridines with trifluoromethanesulfonic anhydride was systematically examined, and characteristic IR absorption bands for the corresponding N-trifluoromethanesulfonylated pyridinium trifluoromethanesulfonates were assigned. The reversible formation of diiminium ether intermediates was studied, providing insight into divergent mechanistic pathways as a function of the steric environment of the amide substrate and stoichiometry of reagents. Importantly, when considering base additives during electrophilic amide activation, more hindered α-quaternary tertiary lactams require the use of non-nucleophilic pyridine additives in order to avoid deactivation via a competing desulfonylation reaction. The isolation and full characterization of a tetracyclic iminium trifluoromethanesulfonate provided additional correlation between in situ characterization of sensitive intermediates and isolable compounds involved in this synthetic transformation. PMID:26166404

  11. Data analysis of response interruption and redirection as a treatment for vocal stereotypy.

    PubMed

    Wunderlich, Kara L; Vollmer, Timothy R

    2015-12-01

    Vocal stereotypy, or repetitive, noncontextual vocalizations, is a problematic form of behavior exhibited by many individuals with autism spectrum disorder (ASD). Recent research has evaluated the efficacy of response interruption and redirection (RIRD) in the reduction of vocal stereotypy. Research has indicated that RIRD often results in reductions in the level of vocal stereotypy; however, many previous studies have only presented data on vocal stereotypy that occurred outside RIRD implementation. The current study replicated the procedures of previous studies that have evaluated the efficacy of RIRD and compared 2 data-presentation methods: inclusion of only data collected outside RIRD implementation and inclusion of all vocal stereotypy data from the entirety of each session. Subjects were 7 children who had been diagnosed with ASD. Results indicated that RIRD appeared to be effective when we evaluated the level of vocal stereotypy outside RIRD implementation, but either no reductions or more modest reductions in the level of vocal stereotypy during the entirety of sessions were obtained for all subjects. Results suggest that data-analysis methods used in previous research may overestimate the efficacy of RIRD. PMID:26173813

  12. Improving malaria control in West Africa: interruption of transmission as a paradigm shift.

    PubMed

    Doumbia, Seydou O; Ndiaye, Daouda; Koita, Ousmane A; Diakité, Mahamadou; Nwakanma, Davis; Coulibaly, Mamadou; Traoré, Sekou F; Keating, Joseph; Milner, Danny A; Ndiaye, Jean-Louis; Sene, Papa Diogoye; Ahouidi, Ambroise; Dieye, Tandakha N; Gaye, Oumar; Okebe, Joseph; Ceesay, Serign J; Ngwa, Alfred; Oriero, Eniyou C; Konaté, Lassana; Sy, Ngayo; Jawara, Musa; Faye, Ousmane; Kéita, Moussa; Cissé, Moussa; Sogoba, Nafomon; Poudiougou, Belco; Diawara, Sory; Sangaré, Lansana; Coulibaly, Tinzana; Seck, Ibrahima; Abubakar, Ismaela; Gomis, Jules; Mather, Frances J; Sissako, Aliou; Diarra, Ayouba; Kandeh, Balla; Whalen, Christopher; Moyer, Brian; Nnedu, Obinna; Thiero, Oumar; Bei, Amy K; Daniels, Rachel; Miura, Kazutoyo; Long, Carole A; Fairhurst, Rick M; Duraisingh, Manoj; Muskavitch, Marc A T; D'Alessandro, Umberto; Conway, David J; Volkman, Sarah K; Valim, Clarissa; Wirth, Dyann F; Krogstad, Donald J

    2012-03-01

    With the paradigm shift from the reduction of morbidity and mortality to the interruption of transmission, the focus of malaria control broadens from symptomatic infections in children ≤5 years of age to include asymptomatic infections in older children and adults. In addition, as control efforts intensify and the number of interventions increases, there will be decreases in prevalence, incidence and transmission with additional decreases in morbidity and mortality. Expected secondary consequences of these changes include upward shifts in the peak ages for infection (parasitemia) and disease, increases in the ages for acquisition of antiparasite humoral and cellular immune responses and increases in false-negative blood smears and rapid diagnostic tests. Strategies to monitor these changes must include: (1) studies of the entire population (that are not restricted to children ≤5 or ≤10 years of age), (2) study sites in both cities and rural areas (because of increasing urbanization across sub-Saharan Africa) and (3) innovative strategies for surveillance as the prevalence of infection decreases and the frequency of false-negative smears and rapid diagnostic tests increases. PMID:22142790

  13. Direct Observation of Intermediates Involved in the Interruption of the Bischler–Napieralski Reaction

    PubMed Central

    White, Kolby L.; Mewald, Marius; Movassaghi, Mohammad

    2015-01-01

    The first mechanistic investigation of electrophilic amide activation of α,α-disubstituted tertiary lactams and the direct observation of key intermediates by in situ FTIR, 1H, 13C, and 19F NMR in our interrupted Bischler–Napieralski based synthetic strategy to the aspidosperma alkaloids, including a complex tetracyclic diiminium ion, is discussed. The reactivity of a wide range of pyridines with trifluoromethanesulfonic anhydride was systematically examined, and characteristic IR absorption bands for the corresponding N-trifluoromethanesulfonylated pyridinium trifluoromethanesulfonates were assigned. The reversible formation of diiminium ether intermediates was studied, providing insight into divergent mechanistic pathways as a function of the steric environment of the amide substrate and stoichiometry of reagents. Importantly, when considering base additives during electrophilic amide activation, more hindered α-quaternary tertiary lactams require the use of non-nucleophilic pyridine additives in order to avoid deactivation via a competing desulfonylation reaction. The isolation and full characterization of a tetracyclic iminium trifluoromethanesulfonate provided additional correlation between in situ characterization of sensitive intermediates and isolable compounds involved in this synthetic transformation. PMID:26166404

  14. Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression

    PubMed Central

    Kim, Jung Ha; Park, Jong-Jae; Lee, Beom Jae; Joo, Moon Kyung; Chun, Hoon Jai; Lee, Sang Woo; Bak, Young-Tae

    2016-01-01

    Background/Aims Astaxanthin is a carotenoid pigment that has antioxidant, antitumoral, and anti-inflammatory properties. In this in vitro study, we investigated the mechanism of anticancer effects of astaxanthin in gastric carcinoma cell lines. Methods The human gastric adenocarcinoma cell lines AGS, KATO-III, MKN-45, and SNU-1 were treated with various concentrations of astaxanthin. A cell viability test, cell cycle analysis, and immunoblotting were performed. Results The viability of each cancer cell line was suppressed by astaxanthin in a dose-dependent manner with significantly decreased proliferation in KATO-III and SNU-1 cells. Astaxanthin increased the number of cells in the G0/G1 phase but reduced the proportion of S phase KATO-III and SNU-1 cells. Phosphorylated extracellular signal-regulated kinase (ERK) was decreased in an inverse dose-dependent correlation with astaxanthin concentration, and the expression of p27kip-1 increased the KATO-III and SNU-1 cell lines in an astaxanthin dose-dependent manner. Conclusions Astaxanthin inhibits proliferation by interrupting cell cycle progression in KATO-III and SNU-1 gastric cancer cells. This may be caused by the inhibition of the phosphorylation of ERK and the enhanced expression of p27kip-1. PMID:26470770

  15. Dolphins can maintain vigilant behavior through echolocation for 15 days without interruption or cognitive impairment.

    PubMed

    Branstetter, Brian K; Finneran, James J; Fletcher, Elizabeth A; Weisman, Brian C; Ridgway, Sam H

    2012-01-01

    In dolphins, natural selection has developed unihemispheric sleep where alternating hemispheres of their brain stay awake. This allows dolphins to maintain consciousness in response to respiratory demands of the ocean. Unihemispheric sleep may also allow dolphins to maintain vigilant states over long periods of time. Because of the relatively poor visibility in the ocean, dolphins use echolocation to interrogate their environment. During echolocation, dolphin produce clicks and listen to returning echoes to determine the location and identity of objects. The extent to which individual dolphins are able to maintain continuous vigilance through this active sense is unknown. Here we show that dolphins may continuously echolocate and accurately report the presence of targets for at least 15 days without interruption. During a total of three sessions, each lasting five days, two dolphins maintained echolocation behaviors while successfully detecting and reporting targets. Overall performance was between 75 to 86% correct for one dolphin and 97 to 99% correct for a second dolphin. Both animals demonstrated diel patterns in echolocation behavior. A 15-day testing session with one dolphin resulted in near perfect performance with no significant decrement over time. Our results demonstrate that dolphins can continuously monitor their environment and maintain long-term vigilant behavior through echolocation. PMID:23082170

  16. Interruption of Electrical Conductivity of Titanium Dental Implants Suggests a Path Towards Elimination Of Corrosion

    PubMed Central

    Pozhitkov, Alex E.; Daubert, Diane; Brochwicz Donimirski, Ashley; Goodgion, Douglas; Vagin, Mikhail Y.; Leroux, Brian G.; Hunter, Colby M.; Flemmig, Thomas F.; Noble, Peter A.; Bryers, James D.

    2015-01-01

    Peri-implantitis is an inflammatory disease that results in the destruction of soft tissue and bone around the implant. Titanium implant corrosion has been attributed to the implant failure and cytotoxic effects to the alveolar bone. We have documented the extent of titanium release into surrounding plaque in patients with and without peri-implantitis. An in vitro model was designed to represent the actual environment of an implant in a patient’s mouth. The model uses actual oral microbiota from a volunteer, allows monitoring electrochemical processes generated by biofilms growing on implants and permits control of biocorrosion electrical current. As determined by next generation DNA sequencing, microbial compositions in experiments with the in vitro model were comparable with the compositions found in patients with implants. It was determined that the electrical conductivity of titanium implants was the key factor responsible for the biocorrosion process. The interruption of the biocorrosion current resulted in a 4–5 fold reduction of corrosion. We propose a new design of dental implant that combines titanium in zero oxidation state for osseointegration and strength, interlaid with a nonconductive ceramic. In addition, we propose electrotherapy for manipulation of microbial biofilms and to induce bone healing in peri-implantitis patients. PMID:26461491

  17. Dolphins Can Maintain Vigilant Behavior through Echolocation for 15 Days without Interruption or Cognitive Impairment

    PubMed Central

    Branstetter, Brian K.; Finneran, James J.; Fletcher, Elizabeth A.; Weisman, Brian C.; Ridgway, Sam H.

    2012-01-01

    In dolphins, natural selection has developed unihemispheric sleep where alternating hemispheres of their brain stay awake. This allows dolphins to maintain consciousness in response to respiratory demands of the ocean. Unihemispheric sleep may also allow dolphins to maintain vigilant states over long periods of time. Because of the relatively poor visibility in the ocean, dolphins use echolocation to interrogate their environment. During echolocation, dolphin produce clicks and listen to returning echoes to determine the location and identity of objects. The extent to which individual dolphins are able to maintain continuous vigilance through this active sense is unknown. Here we show that dolphins may continuously echolocate and accurately report the presence of targets for at least 15 days without interruption. During a total of three sessions, each lasting five days, two dolphins maintained echolocation behaviors while successfully detecting and reporting targets. Overall performance was between 75 to 86% correct for one dolphin and 97 to 99% correct for a second dolphin. Both animals demonstrated diel patterns in echolocation behavior. A 15-day testing session with one dolphin resulted in near perfect performance with no significant decrement over time. Our results demonstrate that dolphins can continuously monitor their environment and maintain long-term vigilant behavior through echolocation. PMID:23082170

  18. Safety of anticoagulation with uninterrupted warfarin vs. interrupted dabigatran in patients requiring an implantable cardiac device

    PubMed Central

    Madan, Shivanshu; Muthusamy, Purushothaman; Mowers, Katie L.; Elmouchi, Darryl A.; Finta, Bohuslav; Gauri, Andre J.; Woelfel, Alan K.; Fritz, Timothy D.; Davis, Alan T.

    2016-01-01

    Background The optimal strategy of peri-procedural anticoagulation in patients undergoing permanent cardiac device implantation is controversial. Our objective was to compare the major bleeding and thromboembolic complications in patients managed with uninterrupted warfarin (UW) vs. interrupted dabigatran (ID) during permanent pacemaker (PPM) or implantable cardioverter defibrillators (ICD) implantation. Methods A retrospective cohort study of all eligible patients from July 2011 through January 2012 was performed. UW was defined as patients who had maintained a therapeutic international normalized ratio (INR) on the day of the procedure. ID was defined as stopping dabigatran ≥12 hours prior to the procedure and then resuming after implantation. Major bleeding events included hemothorax, hemopericardium, intracranial hemorrhage, gastrointestinal bleed, epistaxis, or pocket hematoma requiring surgical intervention. Thromboembolic complications included stroke, transient ischemic attack, deep venous thrombosis, pulmonary embolism, or arterial embolism. Results Of the 133 patients (73.4±11.0 years; 91 males) in the study, 86 received UW and 47 received ID. One (1.2%) patient in the UW group sustained hemopericardium perioperatively and died. In comparison, the ID patients had no complications. As compared to the ID group, the UW group had a higher median CHADS2 score (2 vs. 3, P=0.04) and incidence of Grade 1 pocket hematoma (0% vs. 7%, P=0.09). Neither group developed any thromboembolic complications. Conclusions Major bleeding rates were similar among UW and ID groups. Perioperative ID appears to be a safe anticoagulation strategy for patients undergoing PPM or ICD implantation. PMID:26885486

  19. Critical job events, acute stress, and strain: a multiple interrupted time series.

    PubMed

    Eden, D

    1982-12-01

    A critical job event (CJE) is defined as a time-bounded peak of performance demand made on the individual as an integral part of his job. Though such events are an important source of acute job stress and are amenable to longitudinal study, relevant research has been scant. In the present study, the effects of acute objective stress on subjective stress and on psychological and physiological strain were assessed among 39 first-year nursing students in an interrupted time series with multiple replications. Strain was measured five times, twice in anticipation of CJE interspersed by three low-stress occasions. The CJEs were providing the first comprehensive patient care and the final exam in nursing. A consistently confirmatory pattern of significantly rising and falling strain was found for anxiety, systolic blood pressure, and pulse rate: qualitative overload and serum uric acid changed as predicted four times out of five. CJE research can redress past overemphasis on chronic organizational stress and strengthen causal interpretation. PMID:10257633

  20. Reduction in Male Suicide Mortality Following the 2006 Russian Alcohol Policy: An Interrupted Time Series Analysis

    PubMed Central

    Chamlin, Mitchell B.; Andreev, Evgeny

    2013-01-01

    Objectives. We took advantage of a natural experiment to assess the impact on suicide mortality of a suite of Russian alcohol policies. Methods. We obtained suicide counts from anonymous death records collected by the Russian Federal State Statistics Service. We used autoregressive integrated moving average (ARIMA) interrupted time series techniques to model the effect of the alcohol policy (implemented in January 2006) on monthly male and female suicide counts between January 2000 and December 2010. Results. Monthly male and female suicide counts decreased during the period under study. Although the ARIMA analysis showed no impact of the policy on female suicide mortality, the results revealed an immediate and permanent reduction of about 9% in male suicides (Ln ω0 = −0.096; P = .01). Conclusions. Despite a recent decrease in mortality, rates of alcohol consumption and suicide in Russia remain among the highest in the world. Our analysis revealed that the 2006 alcohol policy in Russia led to a 9% reduction in male suicide mortality, meaning the policy was responsible for saving 4000 male lives annually that would otherwise have been lost to suicide. Together with recent similar findings elsewhere, our results suggest an important role for public health and other population level interventions, including alcohol policy, in reducing alcohol-related harm. PMID:24028249

  1. Effects of elevated temperatures during interruption of irradiation on Harwell Red 4034 PMMA and Kodak Biomax alanine film dosimetry systems

    NASA Astrophysics Data System (ADS)

    Sidereas, P.; Patil, D. S.; Garcia, R.; Tracy, R. P.; Holzman, J. M.

    2007-11-01

    In the industrial setting it is not uncommon for a process interruption to occur during irradiation. In this event, dosimeters may be exposed to prolonged periods of elevated temperature without exposure to ionizing radiation. Once the process is restarted, the same dosimeters are exposed to ionizing radiation in order to achieve target dose. The goal of this experiment was to simulate a process interruption within limits and quantify the effects of a combination of factors (heat, time, and fractionation) on dosimeter response. We present an in-depth experimental study on the response of dosimeters that have been irradiated, stored for a fixed period of time at several temperatures, and then re-irradiated. This study was performed using Harwell Red 4034 polymethylmethacrylate (PMMA) and Kodak BioMax alanine film dosimeters.

  2. Surface-morphology evolution during growth-interrupt in situ annealing on GaAs(110) epitaxial layers

    SciTech Connect

    Yoshita, Masahiro; Akiyama, Hidefumi; Pfeiffer, Loren N.; West, Ken W.

    2007-05-15

    Temperature and surface-coverage dependence of the evolution of surface morphology during growth-interrupt in situ annealing on GaAs epitaxial layers grown on the singular (110) cleaved edges by the cleaved-edge overgrowth method with molecular-beam epitaxy has been studied by means of atomic force microscopy. Annealing at substrate temperatures below 630 degree sign C produced atomically flat surfaces with characteristic islands or pits, depending on the surface coverage. The atomic flatness of the surfaces is enhanced with increasing annealing temperature owing to the enhanced adatom migration. At a higher annealing temperature of about 650 degree sign C, however, 2-monolayer-deep triangular pits with well-defined step edges due to Ga-atom desorption from the crystal appeared in the atomically flat surface. The growth-interrupt annealing temperature optimal for the formation of atomically flat GaAs(110) surfaces is therefore about 630 degree sign C.

  3. Development of a Discharge Channel upon Electric Explosion of a Wire in Interrupted- and Uninterrupted-Current Regimes

    SciTech Connect

    Romanova, Vera; Tkachenko, Svetlana; Mingaleev, Albert; Agafonov, Alexey; Ter-Oganesyan, Alexey; Shelkovenko, Tatiana; Pikuz, Sergey

    2009-01-21

    Experimental results on the electrical explosion of thin W, Cu and Ni wires with a current density of {approx}10{sup 12} A/m{sup 2}, a current rise rate (dI/dt){approx}40 A/ns and a current pulse with amplitude 9 kA are presented. The structures of the discharge channels developed in single wire explosions in air and vacuum using laser shadow and schlieren imaging have been studied under the condition that the current in the circuit was interrupted. A difference in the shock wave propagation in air and the expansion of the exploded wire dense core in interrupted- and uninterrupted-current regimes has been observed. Analysis of the optical images has been performed in a shunting breakdown scenario.

  4. Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy

    PubMed Central

    Stephenson, Kathryn E.; Neubauer, George H.; Bricault, Christine A.; Shields, Jennifer; Bayne, Madeleine; Reimer, Ulf; Pawlowski, Nikolaus; Knaute, Tobias; Zerweck, Johannes; Seaman, Michael S.; Rosenberg, Eric S.; Barouch, Dan H.

    2016-01-01

    The examination of antibody responses in human immunodeficiency virus (HIV)-1-infected individuals in the setting of antiretroviral treatment (ART) interruption can provide insight into the evolution of antibody responses during viral rebound. In this study, we assessed antibody responses in 20 subjects in AIDS Clinical Trials Group A5187, wherein subjects were treated with antiretroviral therapy during acute/early HIV-1 infection, underwent analytic treatment interruption, and subsequently demonstrated viral rebound. Our data suggest that early initiation of ART arrests the maturation of HIV-1-specific antibody responses, preventing epitope diversification of antibody binding and the development of functional neutralizing capacity. Antibody responses do not appear permanently blunted, however, because viral rebound triggered the resumption of antibody maturation in our study. We also found that antibody responses measured by these assays did not predict imminent viral rebound. These data have important implications for the HIV-1 vaccine and eradication fields. PMID:27419172

  5. Finding intron/exon splice junctions using INFO, INterruption Finder and Organizer.

    PubMed

    Laub, M T; Smith, D W

    1998-01-01

    INFO, INterruption Finder and Organizer, has been used to find coding sequence intron-exon splice junctions in human and other DNA by comparing the six conceptual translations of the input DNA sequence with sequences in protein databanks using a similarity matrix and windowing algorithm. Similarities detected both delineate position of the gene and provide clues as to the function of the gene product. In addition to use of a standard similarity matrix and windowing algorithm, INFO uses two novel steps, the MiniLibrary and Reverse Sequence steps, to enhance identification of small exons and to improve precision of junction nucleotide delineation. Exons as small as about 30 bases can be reliably found, and > 90% of junctions are precisely identified when canonical splice junction information is used. With the MiniLibrary and Reverse Sequence steps, INFO parameters need not be optimized by the user. In comparative test runs using 19 human DNA sequences, INFO found 108 of 111 exons, with 0 reported false positives, compared with 111 exons and 51 false positives for BLASTX, 99 exons and 6 false positives for GRAIL II, 77 exons and 24 false positives for GeneMark, 61 exons and 9 false positives for GeneID, and 105 exons and 6 false positives for PROCRUSTES. The correlation coefficient for finding and positioning these 111 exons was greater than 98% for INFO. Comparable results were obtained in test runs of 13 nonhuman DNA sequences. INFO is applicable to DNA from any species, will become more robust as sequence databanks expand, and complements other heuristic approaches. PMID:9672834

  6. Implications of interrupted eye-head gaze shifts for resettable integrator reset.

    PubMed

    Kardamakis, A A; Moschovakis, A K

    2006-06-30

    The neural circuit responsible for saccadic eye movements is generally thought to resemble a closed loop controller. Several models of the saccadic system assume that the feedback signal of such a controller is an efference copy of "eye displacement", a neural estimate of the distance already travelled by the eyes, provided by the so-called "resettable integrator" (RI). The speed, with which the RI is reset, is thought to be fast or instantaneous by some authors and gradual by others. To examine this issue, psychophysicists have taken advantage of the target-distractor paradigm. Subjects engaged in it, are asked to look to only one of two stimuli (the "target") and not to a distractor presented in the diametrically opposite location and they often generate movement sequences in which a gaze shift towards the "distractor" is followed by a second gaze shift to the "target". The fact that the second movement is not systematically erroneous even when very short time intervals (about 5 ms) separate it from the first movement has been used to question the verisimilitude of gradual RI reset. To explore this matter we used a saccade-generating network that relies on a RI coupled to a head controller and a model of the rotational vestibulo-ocular reflex. An analysis of the activation functions of model units provides disproof by counterexample: "targets" can be accurately acquired even when the RI of the saccadic burst generator is not reset at all after the end of the first, interrupted eye-head gaze shift to the distractor and prior to the second, complete eye-head gaze shift to the "target". PMID:16782506

  7. Use of interrupted time series analysis in evaluating health care quality improvements.

    PubMed

    Penfold, Robert B; Zhang, Fang

    2013-01-01

    Interrupted time series (ITS) analysis is arguably the strongest quasi-experimental research design. ITS is particularly useful when a randomized trial is infeasible or unethical. The approach usually involves constructing a time series of population-level rates for a particular quality improvement focus (eg, rates of attention-deficit/hyperactivity disorder [ADHD] medication initiation) and testing statistically for a change in the outcome rate in the time periods before and time periods after implementation of a policy/program designed to change the outcome. In parallel, investigators often analyze rates of negative outcomes that might be (unintentionally) affected by the policy/program. We discuss why ITS is a useful tool for quality improvement. Strengths of ITS include the ability to control for secular trends in the data (unlike a 2-period before-and-after t test), ability to evaluate outcomes using population-level data, clear graphical presentation of results, ease of conducting stratified analyses, and ability to evaluate both intended and unintended consequences of interventions. Limitations of ITS include the need for a minimum of 8 time periods before and 8 after an intervention to evaluate changes statistically, difficulty in analyzing the independent impact of separate components of a program that are implemented close together in time, and existence of a suitable control population. Investigators must also be careful not to make individual-level inferences when population-level rates are used to evaluate interventions (though ITS can be used with individual-level data). A brief description of ITS is provided, including a fully implemented (but hypothetical) study of the impact of a program to reduce ADHD medication initiation in children younger than 5 years old and insured by Medicaid in Washington State. An example of the database needed to conduct an ITS is provided, as well as SAS code to implement a difference-in-differences model using

  8. Within-season flowering interruptions are common in the water-limited Sky Islands

    NASA Astrophysics Data System (ADS)

    Crimmins, Theresa M.; Bertelsen, C. David; Crimmins, Michael A.

    2014-05-01

    Within-season breaks in flowering have been reported in a wide range of highly variable ecosystems including deserts, tropical forests and high-elevation meadows. A tendency for interruptions in flowering has also been documented in southwestern US "Sky Island" plant communities, which encompass xeric to mesic conditions. Seasonal breaks in flowering have implications for plant reproductive success, population structure, and gene flow as well as resource availability for pollinators and dependent animals. Most reports of multiple within-season flowering events describe only two distinct flowering episodes. In this study, we set out to better quantify distinct within-season flowering events in highly variable Sky Islands plant communities. Across a >1,200 m elevation gradient, we documented a strong tendency for multiple within-season flowering events. In both distinct spring and summer seasons, we observed greater than two distinct within-season flowering in more than 10 % of instances. Patterns were clearly mediated by the different climate factors at work in the two seasons. The spring season, which is influenced by both temperature and precipitation, showed a mixed response, with the greatest tendency for multiple flowering events occurring at mid-elevations and functional types varying in their responses across the gradient. In the summer season, during which flowering across the gradient is limited by localized precipitation, annual plants exhibited the fewest within-season flowering events and herbaceous perennial plants showed the greatest. Additionally, more distinct events occurred at lower elevations. The patterns documented here provide a baseline for comparison of system responses to changing climate conditions.

  9. Evaluating the efficacy of therapeutic HIV vaccines through analytical treatment interruptions

    PubMed Central

    Graziani, Gina M; Angel, Jonathan B

    2015-01-01

    Introduction The development of an effective therapeutic HIV vaccine that induces immunologic control of viral replication, thereby eliminating or reducing the need for antiretroviral therapy (ART), would be of great value. Besides the obvious challenges of developing a therapeutic vaccine that would generate effective, sustained anti-HIV immunity in infected individuals is the issue of how to best assess the efficacy of vaccine candidates. Discussion This review discusses the various outcome measures assessed in therapeutic HIV vaccine clinical trials involving individuals receiving suppressive ART, with a particular focus on the role of analytical treatment interruption (ATI) as a way to assess the virologic control induced by an immunotherapy. This strategy is critical given that there are otherwise no readily available measures to determine the ability of a vaccine-induced immune response to effectively control HIV replication. The various outcome measures that have been used to assess vaccine efficacy in published therapeutic HIV vaccine clinical trials will also be discussed. Outcome measures have included the kinetics of viral rebound, the new viral set point and changes in the size of the viral reservoir. Clinically relevant outcomes such as the CD4 decline, the time to resume therapy or the time to meet the criterion to resume therapy, the proportion of participants who resume therapy and/or the development of clinical symptoms such as acute retroviral syndrome are also measures of vaccine efficacy. Conclusions Given the lack of consistency between therapeutic HIV vaccine trials in how efficacy is assessed, comparing vaccines has been difficult. It would, therefore, be beneficial to determine the most clinically relevant measure for use in future studies. Other recommendations for future clinical trials also include studying compartments in addition to blood and replacing ATIs with single-copy assays in situations in which the use of an ATI is not ideal

  10. Chronical sleep interruption-induced cognitive decline assessed by a metabolomics method.

    PubMed

    Feng, Li; Wu, Hong-wei; Song, Guang-qing; Lu, Cong; Li, Ying-hui; Qu, Li-na; Chen, Shan-guang; Liu, Xin-min; Chang, Qi

    2016-04-01

    Good sleep is necessary for optimal health, especially for mental health. Insomnia, sleep deprivation will make your ability to learn and memory impaired. Nevertheless, the underlying pathophysiological mechanism of sleep disorders-induced cognitive decline is still largely unknown. In this study, the sleep deprivation of animal model was induced by chronical sleep interruption (CSI), the behavioral tests, biochemical index determinations, and a liquid chromatography-mass spectrometry (LC-MS) based serum metabolic profiling analysis were performed to explore the effects of CSI on cognitive function and the underlying mechanisms. After 14-days CSI, the cognitive function of the mice was evaluated by new objects preference (NOP) task and temporal order judgment (TOJ) task. Serum corticosterone (CORT), and brain Malondialdehyde (MDA), Superoxide Dismutase (SOD), and Catalase (CAT) levels were determined by ELISA kits. Data were analyzed by Principal Component Analysis (PCA), Partial Least Squares project to latent structures-Discriminant Analysis (PLS-DA), and Student's t-test. We found that the cognitive function of the mice was significantly affected by CSI. Besides, levels of CORT and MDA were higher, and SOD and CAT were lower in CSI mice than those of control. Obvious body weight loss of CSI mice was also observed. Thirteen potential serum biomarkers including choline, valine, uric acid, allantoic acid, carnitines, and retinoids were identified. Affected metabolic pathways involve metabolism of purine, retinoid, lipids, and amino acid. These results showed that CSI can damage the cognitive performance notably. The cognitive decline may ascribe to excessive oxidative stress and a series of disturbed metabolic pathways. PMID:26747207

  11. Interruption of antiretroviral therapy is associated with increased plasma cystatin C

    PubMed Central

    Mocroft, A; Wyatt, C; Szczech, L; Neuhaus, J; El-Sadr, W; Tracy, R; Kuller, L; Shlipak, M; Angus, B; Klinker, H; Ross, M

    2009-01-01

    Background Cystatin C has been proposed as an alternative marker of renal function. We sought to determine if participants randomized to episodic use of antiretroviral therapy guided by CD4+ count (drug conservation; DC) had altered cystatin C levels compared to those randomised to continuous antiretroviral therapy (viral suppression; VS) in the Strategies for Management of Antiretroviral Therapy Trial, and to identify factors associated with increased cystatin C. Methods Cystatin C was measured in plasma collected at randomization, 1, 2, 4, 8 and 12 months after randomization in a random sample of 249 and 250 participants in the DC and VS groups respectively. Logistic regression was used to model the odds of ≥ 0.15 mg/dl increase in cystatin C (1 standard deviation [SD]) in the first month after randomisation, adjusting for demographic and clinical characteristics. Results At randomisation, mean (SD) cystatin C level was 0.99 (0.26 mg/dl) and 1.01 (0.28 mg/dl) in the DC and VS arms respectively (p=0.29). In the first month after randomisation, 21.8% and 10.6% had ≥0.15 mg/dl increase in cystatin C in the DC and VS arm respectively (p=0.0008). The difference in cystatin C between the treatment arms was maintained through 1 year after randomisation. After adjustment, participants in the VS arm had significantly reduced odds of ≥0.15 mg/dl increase in cystatin C in the first month (OR 0.42; 95% CI 0.23–0.74, p=0.0023). Conclusions These results demonstrate that interruption of antiretroviral therapy is associated with an increase in cystatin C, which may reflect worsened renal function. PMID:19050388

  12. Interruptions of the ancient Shu Civilization: triggered by climate change or natural disaster?

    NASA Astrophysics Data System (ADS)

    Wen, Xingyue; Bai, Song; Zeng, Na; Page Chamberlain, C.; Wang, Chengshan; Huang, Chengmin; Zhang, Qing

    2013-04-01

    Environmental proxies of a stable carbon isotope, total organic carbon, free iron oxide, and particle size distribution in sediments as well as the stable carbon and oxygen isotopes in fossil human and animal teeth were used to reconstruct the history of climate change and natural disasters near the Jinsha Relic Site and to track their effect on the ancient Shu Civilization, which was established in the Chengdu Plain of southwest China during the late Holocene. In general, the late Holocene climate in the Chengdu Plain demonstrated a drying and cooling trend, with evident cooler events ~4100 and ~2700 a BP, which coincided with global climate changes. The ancient Shu Civilization was interrupted twice, and it included three stages—the Baodun (4700-3700 a BP), the Sanxingdui (3700-3150 a BP), and the Shi'erqiao (3150-2600 a BP)—that were slightly related to the abrupt climate changes that resulted from the collapse of the classic Sanxingdui Civilization, which was founded in a regional warm period. The abrupt increase in sand content in the sediment from the Jinsha Site coincided with the palaeoearthquake and palaeodam burst in the Longmen Mountains when the Baodun and Shi'erqiao desisted, indicating that a flood had occurred due to a dam burst and may likely have caused the ancient civilization's destruction. Although the warm and humid climate, flat terrain and rich water resources prompted the prosperity of the ancient towns of Sanxingdui and Jinsha, frequent natural disasters, such as powerful earthquakes, landslide dams, and outburst floods, consistently affected the ancient Shu inhabitants.

  13. Influence of safety warnings on ESA prescribing among dialysis patients using an interrupted time series

    PubMed Central

    2013-01-01

    Background In March, 2007, a black box warning was issued by the Food and Drug Administration (FDA) to use the lowest possible erythropoiesis-stimulating agents (ESA) doses for treatment of anemia associated with renal disease. The goal is to determine if a change in ESA use was observed following the warning among US dialysis patients. Methods ESA therapy was examined from September 2004 through August 2009 (thirty months before and after the FDA black box warning) among adult Medicare hemodialysis patients. An interrupted time series model assessed the impact of the warnings. Results The FDA black box warning did not appear to influence ESA prescribing among the overall dialysis population. However, significant declines in ESA therapy after the FDA warnings were observed for selected populations. Patients with a hematocrit ≥36% had a declining month-to-month trend before (−164 units/week, p = <0.0001) and after the warnings (−80 units/week, p = .001), and a large drop in ESA level immediately after the black box (−4,744 units/week, p = <.0001). Not-for-profit facilities had a declining month-to-month trend before the warnings (−90 units/week, p = .009) and a large drop in ESA dose immediately afterwards (−2,487 units/week, p = 0.015). In contrast, for-profit facilities did not have a significant change in ESA prescribing. Conclusions ESA therapy had been both profitable for providers and controversial regarding benefits for nearly two decades. The extent to which a FDA black box warning highlighting important safety concerns influenced use of ESA therapy among nephrologists and dialysis providers was unknown. Our study found no evidence of changes in ESA prescribing for the overall dialysis population resulting from a FDA black box warning. PMID:23927675

  14. Reduction of maternal mortality due to preeclampsia in Colombia-an interrupted time-series analysis

    PubMed Central

    Herrera-Medina, Rodolfo; Herrera-Escobar, Juan Pablo; Nieto-Díaz, Aníbal

    2014-01-01

    Introduction: Preeclampsia is the most important cause of maternal mortality in developing countries. A comprehensive prenatal care program including bio-psychosocial components was developed and introduced at a national level in Colombia. We report on the trends in maternal mortality rates and their related causes before and after implementation of this program. Methods: General and specific maternal mortality rates were monitored for nine years (1998-2006). An interrupted time-series analysis was performed with monthly data on cases of maternal mortality that compared trends and changes in national mortality rates and the impact of these changes attributable to the introduction of a bio-psychosocial model. Multivariate analyses were performed to evaluate correlations between the interventions. Results: Five years after (2002 - 2006) its introduction the general maternal mortality rate was significantly reduced to 23% (OR=0.77, CI 95% 0.71-0.82).The implementation of BPSM also reduced the incidence of preeclampsia in 22% (OR= 0.78, CI 95% 0.67-0.88), as also the labor complications by hemorrhage in 25% (OR=0.75, CI 95% 0.59-0.90) associated with the implementation of red code. The other causes of maternal mortality did not reveal significant changes. Biomedical, nutritional, psychosocial assessments, and other individual interventions in prenatal care were not correlated to maternal mortality (p= 0.112); however, together as a model we observed a significant association (p= 0.042). Conclusions: General maternal mortality was reduced after the implementation of a comprehensive national prenatal care program. Is important the evaluation of this program in others populations. PMID:24970956

  15. Dramatic decrease of carnitine esters after interruption of exogenous carnitine supply in hemodialysis patients.

    PubMed

    Bene, Judit; Csiky, Botond; Wittmann, Istvan; Sulyok, Endre; Melegh, Bela

    2012-01-01

    L-carnitine supplementation is extensively used in patients on maintenance hemodialysis (HD) to improve dialysis-related clinical symptoms. In a series of studies, we investigated the dynamics of carnitine pool in carnitine-supplemented HD patients; here we report dramatic decrease with special changes of the ester profile due to interruption of the exogenous intake after the last HD session. Serum samples were collected from 18 L-carnitine-repleted end-stage renal disease (ESRD) patients before the L-carnitine supplementation, after completion of a carnitine supplementation period treatment (12 weeks, 1 g/IV/HD), right before the HD session, and 44 h after the dialysis. Levels of free carnitine (FC) and the individual esters were determined using electrospray MS/MS technique. Normally, L-carnitine supplementation causes significant elevation of all carnitine compounds to supraphysiological levels, which reaches a standard steady-state-like profile. In this study we found a dramatic decrease in the level of FC, and in short- and medium-chain acylcarnitines (ACs) 44 h after the last dialysis. At the end of this interdialytic period, FC levels increased to only 65% of the predialysis level, whereas the amounts of C2 and C3 esters recovered to only 50%. The level of C6 was 65% of the predialysis level, whereas the amount of C8 chain length ACs returned to 72% of the predialysis level. No significant change was seen in AC concentrations above C10 chain length. Omission of one single dosage of supplemental carnitine in long-term administration schemes results in dramatic decrease and reprofiling of carnitine esters even after the usual 44 h of interdialytic period. PMID:22417076

  16. Cholestasis Reveals Severe Cortisol Deficiency in Neonatal Pituitary Stalk Interruption Syndrome

    PubMed Central

    Mauvais, Francois-Xavier; Gonzales, Emmanuel; Davit-Spraul, Anne; Jacquemin, Emmanuel; Brauner, Raja

    2016-01-01

    Objectives Cholestasis has been reported during the course of congenital hypothalamic-pituitary deficiency, but crucial information is lacking regarding both its origin and prognosis. We aimed to characterize the course of cholestasis and factors contributing to it in patients with deficiency due to pituitary stalk interruption syndrome (PSIS). Methods We conducted a retrospective single-center, case-cohort study including 16 patients with PSIS diagnosed before one year of age. We collected clinical and biological parameters from medical records and compared the characteristics of the endocrine syndrome in PSIS patients with and without cholestasis. Results 5/16 patients had cholestasis, all with a neonatal onset and multiple hypothalamic-pituitary deficiency. Patients with cholestasis presented with lower Apgar score and higher rate of ophthalmic malformations: 3/5 vs 1/11, p = 0.03 and 5/5 vs 4/11, p = 0.02, respectively. The plasma cortisol level was strongly decreased in patients with cholestasis: 12.4 ng/mL (8–15 ng/mL) vs 79.4 ng/mL (10–210 ng/mL), p = 0.04. Cholestasis resolved within 9 months following hormone supplementation. No development of chronic liver disease was observed during a median follow-up of 9.4 years (range, 1.3–13.3 years). Conclusions Cholestasis is a frequent symptom at presentation of PSIS during the neonatal period that may help earlier diagnosis and that indicates a profound cortisol deficiency. PMID:26829045

  17. Characterizing the modification of surface proteins with poly(ethylene glycol) to interrupt platelet adhesion

    PubMed Central

    Xu, Haiyan; Kaar, Joel L.; Russell, Alan J.; Wagner, William R.

    2010-01-01

    Surface protein modification with poly(ethylene glycol) (PEG) can inhibit acute thrombosis on damaged vascular and biomaterial surfaces by blocking surface protein–platelet interactions. However, the feasibility of employing protein reactive PEGs to limit intravascular and biomaterial thrombosis in vivo is contingent upon rapid and extensive surface protein modification. To characterize the factors controlling this potential therapeutic approach, the model protein bovine serum albumin was adsorbed onto polyurethane surfaces and modified with PEG-carboxymethyl succinimidyl ester (PEG-NHS), PEG-isocyanate (PEG-ISO), or PEG-diisocyanate (PEG-DISO) in aqueous buffer at varying concentrations and contact times. It was found that up to 5 PEGs could be attached per albumin molecule within one min and that adsorbed albumin PEGylation approached maximal levels by 6 min. The lability of reactive PEGs in aqueous buffer reduced total protein modification by 50% when the PEG solution was incubated for 7 min prior to application. For fibrinogen PEGylation (performed in the solution phase), PEG-NHS was more reactive than PEG-ISO or PEG-DISO. The γ peptide of fibrinogen, which contains several key platelet-binding motifs, was highly modified. A marked reduction in platelet adhesion was observed on fibrinogen-adsorbed polyurethane treated with PEG-NHS or PEG-DISO. Relative differences in platelet adhesion on PEG-NHS and PEG-DISO modified surfaces could be attributed to differences in reactivity towards fibrinogen and the size of the polymer backbone. Taken together, these findings provide insight and guidance for applying protein reactive PEGs for the interruption of acute thrombotic deposition. PMID:16457880

  18. Socioeconomic and clinical factors explaining the risk of unstructured antiretroviral therapy interruptions among Kenyan adult patients.

    PubMed

    Mûnene, Edwin; Ekman, Björn

    2016-09-01

    A cross-sectional study was conducted to assess the extent of unstructured HIV treatment interruptions (TIs) and investigate the effects of socioeconomic, socio-demographic, HIV treatment-related and clinical factors on the magnitude and rate of the same among adult patients at a Kenyan regional referral center. Four hundred and twenty-one adult patients actively receiving antiretroviral therapy at Nyeri County Referral Hospital since 2003 were randomly selected to complete a health survey questionnaire. Electronic records were used to obtain their HIV treatment utilization history. The marginal effects of selected determinants on prevalence and rate of TI were assessed by fitting multiple Poisson log-linear regression models. In total, 392 patients participated in the study. HIV TI was prevalent with 64.5% having had at least one TI of 3 months or more during treatment. The risk of TI was significantly higher in those longer on treatment (prevalence ratio = 1.2, 95% confidence interval [CI] 1.12-1.28). Greater risk of TI was also associated with lower income (prevalence rate ratio [PRR] = 0.9, 95% CI 0.83-1.00), low medication adherence (PRR = 0.3, 95% CI 0.13-0.72), inconsistent treatment engagement (PRR = 0.4, 95% CI 0.19-0.75) and, contrarily, fewer adverse drug reactions (PRR = 0.9, 95% CI 0.90-0.97). Unstructured HIV TIs appear to be fairly common at the study site. The results suggest that efforts to minimize HIV TI could benefit from treatment-continuity monitoring strategies that target the high-risk sub-samples identified. PMID:26846424

  19. Molecular dynamic simulation studies on the effect of one residue chain staggering on the structure and stability of heterotrimeric collagen-like peptides with interruption.

    PubMed

    Singam, Ettayapuram Ramaprasad Azhagiya; Balamurugan, Kanagasabai; Gopalakrishnan, Ravimohan; Subramanian, Sundar Raman; Subramanian, Venkatesan; Ramasami, Thirumalachari

    2012-11-01

    A systematic molecular dynamics (MD) simulation has been carried out on collagen-like peptides with different combinations of interruptions in the Gly-X(AA) -Y(AA) repeats. Although experimental studies have been carried out to elucidate the structural consequences of homotrimeric collagen-like peptides, this is the first report on the structural effect on the heterotrimeric models with G4G and G1G breaks present simultaneously in the constituent chains with difference in one residue chain staggering. The results reveal that the axial registry of the interrupted region changes significantly from that of conventional triple helical peptide without interruption. Further, results from MD simulations show the formation of a kink in the interrupted region of the triple-helical peptides. The conformational analysis reveals that the interruption in the Gly-X(AA) -Y(AA) pattern in these peptides induces β-strand conformation in triple helical peptides. The conventional hydrogen bonds in the interrupted triad are affected and new nonconventional H-bonds are formed in the triple helical structure, and as a result interrupted region becomes locally fragile. MM-PBSA calculations on the different systems clearly suggest that the binding affinity varies marginally due to one residue staggering. However, it is found from the structural parameters that hydrogen-bonding pattern differs significantly due to the difference in the staggering of chains. PMID:22899360

  20. Temporal trends of time to antiretroviral treatment initiation, interruption and modification: examination of patients diagnosed with advanced HIV in Australia

    PubMed Central

    Wright, Stephen T; Law, Matthew G; Cooper, David A; Keen, Phillip; McDonald, Ann; Middleton, Melanie; Woolley, Ian; Kelly, Mark; Petoumenos, Kathy

    2015-01-01

    Introduction HIV prevention strategies are moving towards reducing plasma HIV RNA viral load in all HIV-positive persons, including those undiagnosed, treatment naïve, on or off antiretroviral therapy. A proxy population for those undiagnosed are patients that present late to care with advanced HIV. The objectives of this analysis are to examine factors associated with patients presenting with advanced HIV, and establish rates of treatment interruption and modification after initiating ART. Methods We deterministically linked records from the Australian HIV Observational Database to the Australian National HIV Registry to obtain information related to HIV diagnosis. Logistic regression was used to identify factors associated with advanced HIV diagnosis. We used survival methods to evaluate rates of ART initiation by diagnosis CD4 count strata and by calendar year of HIV diagnosis. Cox models were used to determine hazard of first ART treatment interruption (duration >30 days) and time to first major ART modification. Results Factors associated (p<0.05) with increased odds of advanced HIV diagnosis were sex, older age, heterosexual mode of HIV exposure, born overseas and rural–regional care setting. Earlier initiation of ART occurred at higher rates in later periods (2007–2012) in all diagnosis CD4 count groups. We found an 83% (69, 91%) reduction in the hazard of first treatment interruption comparing 2007–2012 versus 1996–2001 (p<0.001), and no difference in ART modification for patients diagnosed with advanced HIV. Conclusions Recent HIV diagnoses are initiating therapy earlier in all diagnosis CD4 cell count groups, potentially lowering community viral load compared to earlier time periods. We found a marked reduction in the hazard of first treatment interruption, and found no difference in rates of major modification to ART by HIV presentation status in recent periods. PMID:25865372

  1. Cross-linking to an interrupted polypurine sequence with a platinum-modified triplex-forming oligonucleotide.

    PubMed

    Campbell, Meghan A; Miller, Paul S

    2009-08-01

    Triplex-forming oligonucleotides (TFOs) can bind specifically to polypurine sequences in double-stranded DNA. A single interruption of this polypurine tract can greatly destabilize triplex formation. The stability of triplexes can be significantly enhanced by covalently linking the TFO to its DNA target with reactive functional groups conjugated to the TFO. Covalently cross-linked TFOs are effective inhibitors of transcription of the target DNA sequence. We have designed a TFO with a platinum-modified base that can interact with and cross-link to a cytosine interruption in the polypurine tract of a target DNA duplex. The TFO contains an N(4)-(aminoalkyl)cytosine derivatized with cis-diamminediaquaplatinum(II) or trans-diamminediaquaplatinum(II). When bound to its target, the tethered platinum of the TFO can reach across the major groove and form an adduct with the guanine N7 of the interrupting C.G base pair. The optimal tether length is five methylene groups, and cross-linking is most efficient when the tether is modified with trans-diamminediaquaplatinum(II). Cross-linking requires that the TFO is bound to its designated DNA target. Addition of cyanide to the cross-linked TFO product reversed the cross-link, behavior that is consistent with the presence of a platinum-guanine adduct. The kinetics of the cross-linking reaction were studied and the half-life of the cross-linking reaction was approximately 3 h. Our results demonstrate that platinum-conjugated TFOs can be designed to cross-link with DNA targets that contain a single pyrimidine interruption. Modifications of this type may prove useful for expanding the DNA sequences that can be targeted by TFOs and increasing the stability of the resulting triplexes. PMID:19350290

  2. Enhancing the quantum efficiency of InGaN yellow-green light-emitting diodes by growth interruption

    SciTech Connect

    Du, Chunhua; Ma, Ziguang; Zhou, Junming; Lu, Taiping; Jiang, Yang; Zuo, Peng; Jia, Haiqiang; Chen, Hong

    2014-08-18

    We studied the effect of multiple interruptions during the quantum well growth on emission-efficiency enhancement of InGaN-based yellow-green light emitting diodes on c-plane sapphire substrate. The output power and dominant wavelength at 20 mA are 0.24 mW and 556.3 nm. High resolution x-ray diffraction, photoluminescence, and electroluminescence measurements demonstrate that efficiency enhancement could be partially attributed to crystal quality improvement of the active region resulted from reduced In clusters and relevant defects on the surface of InGaN layer by introducing interruptions. The less tilted energy band in the quantum well is also caused by the decrease of In-content gradient along c-axis resulted from In segregation during the interruptions, which increases spatial overlap of electron-hole wavefunction and thus the internal quantum efficiency. The latter also leads to smaller blueshift of dominant wavelength with current increasing.

  3. Work–Family Conflict, Task Interruptions, and Influence at Work Predict Musculoskeletal Pain in Operating Room Nurses

    PubMed Central

    Nützi, Marina; Koch, Patricia; Baur, Heiner; Elfering, Achim

    2015-01-01

    Background The aim of this study is to examine the prevalence of musculoskeletal complaints in Swiss operating room (OR) nurses, and to investigate how work–family conflict, work interruptions, and influence at work are related to lumbar and cervical back pain. Methods Participants in this correlational questionnaire study included 116 OR nurses from eight different hospitals in Switzerland. Results We found that 66% of the OR staff suffered from musculoskeletal problems. The most prevalent musculoskeletal complaints were lumbar (52.7%) and cervical pain (38.4%). Furthermore, 20.5% reported pain in the mid spine region, 20.5% in the knees and legs, and 9.8% in the hands and feet. Multiple linear regression analyses showed that work–family conflict (p < 0.05) and interruptions (p < 0.05) significantly predicted lumbar and cervical pain in OR nurses, while influence at work (p < 0.05) only predicted lumbar pain. Conclusion These results suggest that reducing the work–family conflict and interruptions at work, as well as offering opportunities to influence one's workplace, help to promote OR nurses' health. PMID:26929846

  4. The effects of brief visual interruption tasks on drivers' ability to resume their visual search for a pre-cued hazard.

    PubMed

    Borowsky, Avinoam; Horrey, William J; Liang, Yulan; Garabet, Angela; Simmons, Lucinda; Fisher, Donald L

    2016-08-01

    Driver visual distraction is known to increase the likelihood of being involved in a crash, especially for long glances inside the vehicle. The detrimental impact of these in-vehicle glances may carry over and disrupt the ongoing processing of information after the driver glances back up on the road. This study explored the effect of different types of visual tasks inside the vehicle on the top-down processes that guide the detection and monitoring of road hazards after the driver glances back towards the road. Using a driving simulator, 56 participants were monitored with an eye tracking system while they navigated various hazardous scenarios in one of four experimental conditions. In all conditions, a potential hazard was visible 4-5s before the driver could strike the potential hazard were it to materialize. All interruptions were exactly two seconds in length. After the interruption the potential hazard again became visible for about a half-second after which the driver passed by the hazard. The nature of the in-vehicle visual interruption presented to the participants was varied across conditions: (1) Visual interruptions comprised of spatial, driving unrelated, tasks; (2) visual interruptions comprised of non-spatial, driving unrelated, tasks; (3) visual interruptions with no tasks added; and (4) no visual interruptions. In the first three conditions drivers glancing on the forward roadway was momentarily interrupted (either with or without a task) just after the potential hazard first became visible by the occurrence of an in-vehicle task lasting two seconds. In the last condition (no interruptions) the driver could not see the potential hazard after it just became visible because of obstructions in the built or natural environment. The obstruction (like the interruption) lasted for two seconds. In other words, across all conditions the hazard was visible, then became invisible, and finally became visible again. Importantly, the results show that the

  5. Cockpit Interruptions and Distractions: Effective Management Requires a Careful Balancing Act

    NASA Technical Reports Server (NTRS)

    Dismukes, R. K.; Young, Grant E.; Sumwalt, Robert L., III; Null, Cynthia H. (Technical Monitor)

    1998-01-01

    Managing several tasks concurrently is an everyday part of cockpit operations. For the most part, crews handle concurrent task demands efficiently, yet crew preoccupation with one task to the detriment of performing other tasks is one of the more common forms of error in the cockpit. Most pilots are familiar with the December 1972 L1011 crash that occurred when the crew became preoccupied with a landing gear light malfunction and failed to notice that someone had inadvertently bumped off the autopilot. More recently a DC-9 landed gear-up in Houston when the crew, preoccupied with an stabilized approach, failed to recognize that the gear was not down because they had not switched the hydraulic pumps to high. We have recently started a research project to study why crews are vulnerable to these sorts of errors. As part of that project we reviewed NTSB reports of accidents attributed to crew error; we concluded that nearly half of these accidents involved lapses of attention associated with interruptions, distractions, or preoccupation with one task to the exclusion of another task. We have also analyzed 107 ASRS reports involving competing tasks; we present here some of our conclusions from those ASRS reports. These 107 reports involved 21 different types of routine tasks crews neglected at a critical moment while attending to another task. Sixty-nine percent of the neglected tasks involved either failure to monitor the current status or position of the aircraft or failure to monitor the actions of the pilot flying or taxiing. Thirty-four different types of competing activities distracted or preoccupied the pilots. Ninety percent of these competing activities fell into one of four broad categories: communication (e.g., discussion among crew or radio communication), heads-down work (e.g., programming the FMS or reviewing approach plates), responding to abnormals, or searching for VMC traffic. We will discuss examples of each of these four categories and suggest things

  6. Training emergency services’ dispatchers to recognise stroke: an interrupted time-series analysis

    PubMed Central

    2013-01-01

    Background Stroke is a time-dependent medical emergency in which early presentation to specialist care reduces death and dependency. Up to 70% of all stroke patients obtain first medical contact from the Emergency Medical Services (EMS). Identifying ‘true stroke’ from an EMS call is challenging, with over 50% of strokes being misclassified. The aim of this study was to evaluate the impact of the training package on the recognition of stroke by Emergency Medical Dispatchers (EMDs). Methods This study took place in an ambulance service and a hospital in England using an interrupted time-series design. Suspected stroke patients were identified in one week blocks, every three weeks over an 18 month period, during which time the training was implemented. Patients were included if they had a diagnosis of stroke (EMS or hospital). The effect of the intervention on the accuracy of dispatch diagnosis was investigated using binomial (grouped) logistic regression. Results In the Pre-implementation period EMDs correctly identified 63% of stroke patients; this increased to 80% Post-implementation. This change was significant (p=0.003), reflecting an improvement in identifying stroke patients relative to the Pre-implementation period both the During-implementation (OR=4.10 [95% CI 1.58 to 10.66]) and Post-implementation (OR=2.30 [95% CI 1.07 to 4.92]) periods. For patients with a final diagnosis of stroke who had been dispatched as stroke there was a marginally non-significant 2.8 minutes (95% CI −0.2 to 5.9 minutes, p=0.068) reduction between Pre- and Post-implementation periods from call to arrival of the ambulance at scene. Conclusions This is the first study to develop, implement and evaluate the impact of a training package for EMDs with the aim of improving the recognition of stroke. Training led to a significant increase in the proportion of stroke patients dispatched as such by EMDs; a small reduction in time from call to arrival at scene by the ambulance also

  7. 41 CFR 301-70.506 - How do we define actual cost and constructive cost when an employee interrupts a travel...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... appropriate en route travel time. ... cost and constructive cost when an employee interrupts a travel assignment because of an incapacitating illness or injury? 301-70.506 Section 301-70.506 Public Contracts and Property Management Federal...

  8. The role of interruptible natural gas customers in New England heating oil markets: A preliminary examination of events in January-February 2000

    SciTech Connect

    2000-11-01

    This report provides an analysis of data collected from gas service providers and end-use customers in the six New England States and offers a preliminary assessment of the impact of interruptible gas customers on the distillate fuel oil market this past winter. Based on information collected and analyzed as of October 2000, the main findings areas follows: (1) For interruptible gas customers with distillate fuel oil as a backup fuel, their volume of interruptions was equivalent to about 1 to 2 percent of the total sales of distillate fuel oil in New England during January-February 2000. For the two peak weeks of gas supply interruptions, however, the equivalent volume of distillate fuel oil amounted to an estimated 3 to 6 percent of total sales in New England. There were no interruptions of the natural gas service during the 2-month period. (2) Purchases of distillate fuel oil by interruptible gas customers may have contributed somewhat to the spike in the price of distillate fuel oil in January-February 2000, especially during the peak weeks of gas interruptions. Nevertheless, other factors--a sudden drop in temperatures, low regional stocks of distillate fuels, and weather-related supply problems during a period of high customer demand--appear to have played a significant role in this price spike, as they have in previous spikes. (3) While this preliminary analysis suggests that interruptible natural gas service does not threaten the stability of the home heating oil market, several steps might be taken-without undermining the benefits of interruptible service--to reduce the potential adverse impacts of gas supply interruptions in times of market stress. Regardless of the magnitude of the impact of distillate fuel oil purchases by interruptible gas customers on Northeast heating oil markets, the threat of future heating oil price spikes and supply problems still remains. To help counter the threat, President Clinton in July 2000 directed Secretary Richardson to

  9. Results of Antiretroviral Treatment Interruption and Intensification in Advanced Multi-Drug Resistant HIV Infection from the OPTIMA Trial

    PubMed Central

    Holodniy, Mark; Brown, Sheldon T.; Cameron, D. William; Kyriakides, Tassos C.; Angus, Brian; Babiker, Abdel; Singer, Joel; Owens, Douglas K.; Anis, Aslam; Goodall, Ruth; Hudson, Fleur; Piaseczny, Mirek; Russo, John; Schechter, Martin; Deyton, Lawrence; Darbyshire, Janet

    2011-01-01

    Background Guidance is needed on best medical management for advanced HIV disease with multidrug resistance (MDR) and limited retreatment options. We assessed two novel antiretroviral (ARV) treatment approaches in this setting. Methods and Findings We conducted a 2×2 factorial randomized open label controlled trial in patients with a CD4 count ≤300 cells/µl who had ARV treatment (ART) failure requiring retreatment, to two options (a) re-treatment with either standard (≤4 ARVs) or intensive (≥5 ARVs) ART and b) either treatment starting immediately or after a 12-week monitored ART interruption. Primary outcome was time to developing a first AIDS-defining event (ADE) or death from any cause. Analysis was by intention to treat. From 2001 to 2006, 368 patients were randomized. At baseline, mean age was 48 years, 2% were women, median CD4 count was 106/µl, mean viral load was 4.74 log10 copies/ml, and 59% had a prior AIDS diagnosis. Median follow-up was 4.0 years in 1249 person-years of observation. There were no statistically significant differences in the primary composite outcome of ADE or death between re-treatment options of standard versus intensive ART (hazard ratio 1.17; CI 0.86–1.59), or between immediate retreatment initiation versus interruption before re-treatment (hazard ratio 0.93; CI 0.68–1.30), or in the rate of non-HIV associated serious adverse events between re-treatment options. Conclusions We did not observe clinical benefit or harm assessed by the primary outcome in this largest and longest trial exploring both ART interruption and intensification in advanced MDR HIV infection with poor retreatment options. Trial Registration Clinicaltrials.gov NCT00050089 PMID:21483491

  10. Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV

    PubMed Central

    Rosenbloom, Daniel I. S.; Goldstein, Edward; Hanhauser, Emily; Kuritzkes, Daniel R.

    2016-01-01

    Monitoring the efficacy of novel reservoir-reducing treatments for HIV is challenging. The limited ability to sample and quantify latent infection means that supervised antiretroviral therapy (ART) interruption studies are generally required. Here we introduce a set of mathematical and statistical modeling tools to aid in the design and interpretation of ART-interruption trials. We show how the likely size of the remaining reservoir can be updated in real-time as patients continue off treatment, by combining the output of laboratory assays with insights from models of reservoir dynamics and rebound. We design an optimal schedule for viral load sampling during interruption, whereby the frequency of follow-up can be decreased as patients continue off ART without rebound. While this scheme can minimize costs when the chance of rebound between visits is low, we find that the reservoir will be almost completely reseeded before rebound is detected unless sampling occurs at least every two weeks and the most sensitive viral load assays are used. We use simulated data to predict the clinical trial size needed to estimate treatment effects in the face of highly variable patient outcomes and imperfect reservoir assays. Our findings suggest that large numbers of patients—between 40 and 150—will be necessary to reliably estimate the reservoir-reducing potential of a new therapy and to compare this across interventions. As an example, we apply these methods to the two “Boston patients”, recipients of allogeneic hematopoietic stem cell transplants who experienced large reductions in latent infection and underwent ART-interruption. We argue that the timing of viral rebound was not particularly surprising given the information available before treatment cessation. Additionally, we show how other clinical data can be used to estimate the relative contribution that remaining HIV+ cells in the recipient versus newly infected cells from the donor made to the residual reservoir

  11. Real-Time Predictions of Reservoir Size and Rebound Time during Antiretroviral Therapy Interruption Trials for HIV.

    PubMed

    Hill, Alison L; Rosenbloom, Daniel I S; Goldstein, Edward; Hanhauser, Emily; Kuritzkes, Daniel R; Siliciano, Robert F; Henrich, Timothy J

    2016-04-01

    Monitoring the efficacy of novel reservoir-reducing treatments for HIV is challenging. The limited ability to sample and quantify latent infection means that supervised antiretroviral therapy (ART) interruption studies are generally required. Here we introduce a set of mathematical and statistical modeling tools to aid in the design and interpretation of ART-interruption trials. We show how the likely size of the remaining reservoir can be updated in real-time as patients continue off treatment, by combining the output of laboratory assays with insights from models of reservoir dynamics and rebound. We design an optimal schedule for viral load sampling during interruption, whereby the frequency of follow-up can be decreased as patients continue off ART without rebound. While this scheme can minimize costs when the chance of rebound between visits is low, we find that the reservoir will be almost completely reseeded before rebound is detected unless sampling occurs at least every two weeks and the most sensitive viral load assays are used. We use simulated data to predict the clinical trial size needed to estimate treatment effects in the face of highly variable patient outcomes and imperfect reservoir assays. Our findings suggest that large numbers of patients-between 40 and 150-will be necessary to reliably estimate the reservoir-reducing potential of a new therapy and to compare this across interventions. As an example, we apply these methods to the two "Boston patients", recipients of allogeneic hematopoietic stem cell transplants who experienced large reductions in latent infection and underwent ART-interruption. We argue that the timing of viral rebound was not particularly surprising given the information available before treatment cessation. Additionally, we show how other clinical data can be used to estimate the relative contribution that remaining HIV+ cells in the recipient versus newly infected cells from the donor made to the residual reservoir that

  12. Factors associated with antiretroviral treatment interruption in human immunodeficiency virus (HIV)-1-infected children attending the Jos University Teaching Hospital, Jos, Nigeria

    PubMed Central

    Ebonyi, Augustine O.; Ejeliogu, Emeka U.; Okpe, Sylvanus E.; Shwe, David D.; Yiltok, Esther S.; Ochoga, Martha O.; Oguche, Stephen

    2015-01-01

    Background: Interrupting anti-retroviral therapy (ART) for any number of reasons is an indication of a compromised adherence to ART. Several factors, including the pill burden from other drugs used in treating co-infections in children with human immunodeficiency virus (HIV), may influence ART adherence. The aim of this study was to identify the factors associated with ART interruption in HIV-1-infected children. Materials and Methods: A retrospective cohort study analysing data on 580 children consecutively enrolled on ART between February 2006 and December 2010 at the paediatric HIV clinic of Jos University Teaching Hospital (JUTH), Jos. Subjects were children aged 2 months — 15 years diagnosed with HIV-1 infection and on first-line ART. Cotrimoxazole prophylaxis was usually commenced at diagnosis while awaiting ART commencement. Children diagnosed with tuberculosis (TB) were also placed on multiple individual anti-TB drugs. Statistical analysis used: A comparison of the data on children with and without ART interruption was made. Variables associated with ART interruption in a univariate analysis were fit in a multivariate logistic model to determine the factors that were associated with ART interruption. Results: Children on anti-TB drugs were twice more likely to interrupt ART compared to those who were not, (adjusted odds ratio, AOR = 1.84 (1.03-3.28); P = 0.04). But children on cotrimoxazole prophylaxis had a 57% reduction in the odds of interrupting ART compared to those who were not, (AOR = 0.43 (0.20-0.93); P = 0.03). Conclusion: Children on ART and also taking multiple individual anti-TB drugs should be monitored closely for ART adherence. Cotrimoxazole prophylaxis should be encouraged in children diagnosed with HIV while awaiting ART commencement as this may prime them for a better ART adherence. PMID:25657493

  13. Neglect in human communication: quantifying the cost of cell-phone interruptions in face to face dialogs.

    PubMed

    Lopez-Rosenfeld, Matías; Calero, Cecilia I; Fernandez Slezak, Diego; Garbulsky, Gerry; Bergman, Mariano; Trevisan, Marcos; Sigman, Mariano

    2015-01-01

    There is a prevailing belief that interruptions using cellular phones during face to face interactions may affect severely how people relate and perceive each other. We set out to determine this cost quantitatively through an experiment performed in dyads, in a large audience in a TEDx event. One of the two participants (the speaker) narrates a story vividly. The listener is asked to deliberately ignore the speaker during part of the story (for instance, attending to their cell-phone). The speaker is not aware of this treatment. We show that total amount of attention is the major factor driving subjective beliefs about the story and the conversational partner. The effects are mostly independent on how attention is distributed in time. All social parameters of human communication are affected by attention time with a sole exception: the perceived emotion of the story. Interruptions during day-to-day communication between peers are extremely frequent. Our data should provide a note of caution, by indicating that they have a major effect on the perception people have about what they say (whether it is interesting or not . . .) and about the virtues of the people around them. PMID:26039326

  14. Neglect in Human Communication: Quantifying the Cost of Cell-Phone Interruptions in Face to Face Dialogs

    PubMed Central

    Lopez-Rosenfeld, Matías; Calero, Cecilia I.; Fernandez Slezak, Diego; Garbulsky, Gerry; Bergman, Mariano; Trevisan, Marcos; Sigman, Mariano

    2015-01-01

    There is a prevailing belief that interruptions using cellular phones during face to face interactions may affect severely how people relate and perceive each other. We set out to determine this cost quantitatively through an experiment performed in dyads, in a large audience in a TEDx event. One of the two participants (the speaker) narrates a story vividly. The listener is asked to deliberately ignore the speaker during part of the story (for instance, attending to their cell-phone). The speaker is not aware of this treatment. We show that total amount of attention is the major factor driving subjective beliefs about the story and the conversational partner. The effects are mostly independent on how attention is distributed in time. All social parameters of human communication are affected by attention time with a sole exception: the perceived emotion of the story. Interruptions during day-to-day communication between peers are extremely frequent. Our data should provide a note of caution, by indicating that they have a major effect on the perception people have about what they say (whether it is interesting or not . . .) and about the virtues of the people around them. PMID:26039326

  15. Transmission of Onchocerca volvulus by Simulium neavei in Mount Elgon focus of Eastern Uganda has been interrupted.

    PubMed

    Katabarwa, Moses; Lakwo, Tom; Habomugisha, Peace; Agunyo, Stella; Byamukama, Edson; Oguttu, David; Ndyomugyenyi, Richard; Tukesiga, Ephraim; Ochieng, Galex Orukan; Abwaimo, Francis; Onapa, Ambrose; Lwamafa, Dennis W K; Walsh, Frank; Unnasch, Thomas R; Richards, Frank O

    2014-06-01

    The study determined that Simulium neavei-transmitted onchocerciasis in Mount Elgon onchocerciasis focus had been interrupted. Annual mass treatment with ivermectin changed to two times per year along with vector elimination in 2007. Then, baseline microfilaria (mf) prevalence data of 1994 in five sentinel communities were compared with follow-up data in 2005 and 2011. Blood spots from 3,051 children obtained in 2009 were analyzed for Onchocerca volvulus immunoglobulin G4 antibodies. Fresh water crab host captures and blackflies collected indicated their infestation with larval stages of S. neavei and presence or absence of the vector, respectively. Mf rates dropped from 62.2% to 0.5%, and 1 (0.03%) of 3,051 children was positive for O. volvulus antibodies. Crab infestation dropped from 41.9% in 2007 to 0%, and S. neavei biting reduced to zero. Both remained zero for the next 3 years, confirming interruption of onchocerciasis transmission, and interventions were halted. PMID:24686740

  16. Whole-Exome Sequencing Identifies Homozygous GPR161 Mutation in a Family with Pituitary Stalk Interruption Syndrome

    PubMed Central

    Karaca, Ender; Buyukkaya, Ramazan; Pehlivan, Davut; Charng, Wu-Lin; Yaykasli, Kursat O.; Bayram, Yavuz; Gambin, Tomasz; Withers, Marjorie; Atik, Mehmed M.; Arslanoglu, Ilknur; Bolu, Semih; Erdin, Serkan; Buyukkaya, Ayla; Yaykasli, Emine; Jhangiani, Shalini N.; Muzny, Donna M.; Gibbs, Richard A.

    2015-01-01

    Context: Pituitary stalk interruption syndrome (PSIS) is a rare, congenital anomaly of the pituitary gland characterized by pituitary gland insufficiency, thin or discontinuous pituitary stalk, anterior pituitary hypoplasia, and ectopic positioning of the posterior pituitary gland (neurohypophysis). The clinical presentation of patients with PSIS varies from isolated growth hormone (GH) deficiency to combined pituitary insufficiency and accompanying extrapituitary findings. Mutations in HESX1, LHX4, OTX2, SOX3, and PROKR2 have been associated with PSIS in less than 5% of cases; thus, the underlying genetic etiology for the vast majority of cases remains to be determined. Objective: We applied whole-exome sequencing (WES) to a consanguineous family with two affected siblings who have pituitary gland insufficiency and radiographic findings of hypoplastic (thin) pituitary gland, empty sella, ectopic neurohypophysis, and interrupted pitiutary stalk—characteristic clinical diagnostic findings of PSIS. Design and Participants: WES was applied to two affected and one unaffected siblings. Results: WES of two affected and one unaffected sibling revealed a unique homozygous missense mutation in GPR161, which encodes the orphan G protein–coupled receptor 161, a protein responsible for transducing extracellular signals across the plasma membrane into the cell. Conclusion: Mutations of GPR161 may be implicated as a potential novel cause of PSIS. PMID:25322266

  17. Monitoring Delamination of Thermal Barrier Coating During Interrupted High-Heat Flux Laser Testing Using Upconversion Luminescence Imaging

    NASA Technical Reports Server (NTRS)

    Eldridge, Jeffrey I.; Zhu, Dongming; Wolfe, Douglas E.

    2011-01-01

    Upconversion luminescence imaging of thermal barrier coatings (TBCs) has been shown to successfully monitor TBC delamination progression during interrupted furnace cycling. However, furnace cycling does not adequately model engine conditions where TBC-coated components are subjected to significant heat fluxes that produce through-thickness temperature gradients that may alter both the rate and path of delamination progression. Therefore, new measurements are presented based on luminescence imaging of TBC-coated specimens subjected to interrupted high-heat-flux laser cycling exposures that much better simulate the thermal gradients present in engine conditions. The TBCs tested were deposited by electron-beam physical vapor deposition (EB-PVD) and were composed of 7wt% yttria-stabilized zirconia (7YSZ) with an integrated delamination sensing layer composed of 7YSZ co-doped with erbium and ytterbium (7YSZ:Er,Yb). The high-heat-flux exposures that produce the desired through-thickness thermal gradients were performed using a high power CO2 laser operating at a wavelength of 10.6 microns. Upconversion luminescence images revealed the debond progression produced by the cyclic high-heat-flux exposures and these results were compared to that observed for furnace cycling.

  18. Feasibility of bloodless liver resection using Lumagel, a reverse thermoplastic polymer, to produce temporary, targeted hepatic blood flow interruption

    PubMed Central

    Pomposelli, James J; Akoad, Mohamed; Flacke, Sebastian; Benn, James J; Solano, Mauricio; Kalra, Aarti; Madras, Peter N

    2012-01-01

    Background Lumagel, a reverse thermosensitive polymer (RTP), provides targeted flow interruption to the kidney by reversibly plugging segmental branches of the renal artery, allowing blood-free partial nephrectomy. Extending this technology to the liver requires the development of techniques for temporary occlusion of the hepatic artery and selected portal vein branches. Methods A three-phased, 15 swine study was performed to determine feasibility, techniques and survival implications of using Lumagel for occlusion of inflow vessels to targeted portions of the liver. Lumagel was delivered using angiographic techniques to sites determined by pre-operative 3-D vascular reconstructions of arterial and venous branches. During resection, the targeted liver mass was resected without vascular clamping. Three survival swine were sacrificed at 3 weeks; the remainder at 6 weeks for pathological studies. Results Six animals (100%) survived, with normal growth, blood tests and no adverse events. Three left lateral lobe resections encountered no bleeding during resection; one right median resection bled; two control animals bled significantly. Pre-terminal angiography and autopsy showed no local pathology and no remote organ damage. Conclusions Targeted flow interruption to the left lateral lobe of the swine liver is feasible and allows resection without bleeding, toxicity or pathological sequelae. Targeting the remaining liver will require more elaborate plug deposition owing to the extensive collateral venous network. PMID:22221572

  19. Cardiac Surgical Repair Should Be Offered to Infants with Trisomy 18, Interrupted Aortic Arch and Ventricular Septal Defect.

    PubMed

    Kavarana, Minoo N

    2016-06-01

    The management of children born with trisomy 18 is controversial, and both providers and parents often have differing opinions. Many parents choose to terminate the pregnancy while others go forward, making decisions based on their beliefs, understanding, and physician recommendations. Physicians are similarly divided regarding treatment of these children, as some feel that aggressive treatments are futile while others defer to the parents' wishes.Interrupted aortic arch with ventricular septal defect in children with trisomy 18 presents an ethical dilemma that highlights the kinds of controversies in medical decision making facing physicians on a daily basis. Repair of interrupted aortic arch with ventricular septal defect poses a high risk to newborns with or without trisomy 18. Therefore, the option for surgery should be treated as with any routine informed consent process. Parents should be counseled about the risks, benefits, alternatives, and the likelihood of success both short and long term and be should offered a choice between surgery and palliative care. PMID:27338603

  20. HIV-1 protein gp120 rapidly impairs memory in chicks by interrupting the glutamate-glutamine cycle.

    PubMed

    Fernandes, S P; Edwards, T M; Ng, K T; Robinson, S R

    2007-01-01

    Learning and memory impairments are frequently observed in patients suffering from AIDS Dementia Complex (ADC). These effects have been linked to the presence of gp120, an HIV viral coat glycoprotein. The present study investigated the possibility that gp120 prevents the uptake of extracellular glutamate by astrocytes, leading to an interruption of the glutamate-glutamine cycle and a subsequent impairment of memory. Ten microliters of 10nM gp120 was bilaterally injected into the region of the intermediate medial mesopallium of day-old chicks at various times before, or after, training using a single-trial passive avoidance task. Gp120 was found to significantly impair memory retention when injected 10-40 min after training. Memory impairments were evident within 5 min of gp120 administration and remained evident 24h later. Further, the amnestic effect of gp120 could be overcome with glutamine or with precursors of glutamate synthesis, but only weakly by glutamate. These results support the conclusion that the amnestic effect of gp120 is due to an impaired uptake of glutamate by astrocytes and a subsequent interruption of glutamine supply to neurones. The data indicate that the glutamate-glutamine cycle may be a useful therapeutic target in the treatment of ADC. PMID:16714124

  1. SIRT3 participates in glucose metabolism interruption and apoptosis induced by BH3 mimetic S1 in ovarian cancer cells.

    PubMed

    Xiang, Xi-Yan; Kang, Jin-Song; Yang, Xiao-Chun; Su, Jing; Wu, Yao; Yan, Xiao-Yu; Xue, Ya-Nan; Xu, Ye; Liu, Yu-He; Yu, Chun-Yan; Zhang, Zhi-Chao; Sun, Lian-Kun

    2016-08-01

    The Bcl-2 antiapoptotic proteins are important cancer therapy targets; however, their role in cancer cell metabolism remains unclear. We found that the BH3-only protein mimetic S1, a novel pan Bcl-2 inhibitor, simultaneously interrupted glucose metabolism and induced apoptosis in human SKOV3 ovarian cancer cells, which was related to the activation of SIRT3, a stress-responsive deacetylase. S1 interrupted the cellular glucose metabolism mainly through causing damage to mitochondrial respiration and inhibiting glycolysis. Moreover, S1 upregulated the gene and protein expression of SIRT3, and induced the translocation of SIRT3 from the nucleus to mitochondria. SIRT3 silencing reversed the effects of S1 on glucose metabolism and apoptosis through increasing the level of HK-II localized to the mitochondria, while a combination of the glycolysis inhibitor 2-DG and S1 intensified the cytotoxicity through further upregulation of SIRT3 expression. This study underscores an essential role of SIRT3 in the antitumor effect of Bcl-2 inhibitors in human ovarian cancer through regulating both metabolism and apoptosis. The manipulation of Bcl-2 inhibitors combined with the use of classic glycolysis inhibitors may be rational strategies to improve ovarian cancer therapy. PMID:27277143

  2. Situs inversus with levocardia, infrahepatic interruption of the inferior vena cava, and azygos continuation: a case report.

    PubMed

    Del Prete, Alessandra; Cavaliere, Carlo; Di Pietto, Francesco; De Ritis, Rosaria

    2016-04-01

    Situs inversus incompletus is a rare congenital condition in which the major abdominal organs are reversed or mirrored from their normal positions. It is often associated with multiple congenital anomalies. We present the case of a 38-year-old woman with dyspnea and a clinical history of chronic kidney disease and kidney transplantation. Echocardiography showed a right atrial mass, and analysis of multidetector computed tomography angiography revealed the interruption of the inferior vena cava with an increase of the azygos vein and azygos continuation. These congenital malformations are often associated with deep vein thrombosis and/or pulmonary thromboembolism and explained the occurrence of dyspnea. Cardiac magnetic resonance with contrast medium confirmed the presence of the right atrial mass, the characteristics of which were attributed to interatrial thrombus, which was further confirmed by the success of thrombolytic therapy and the remission of symptoms. In conclusion, we described a case of situs inversus with levocardia in association with infrahepatic interruption of the inferior vena cava, and azygos continuation with cardiac thrombus and chronic renal failure. PMID:25737490

  3. Low Non-structured Antiretroviral Therapy Interruptions in HIV-Infected Persons Who Inject Drugs Receiving Multidisciplinary Comprehensive HIV Care at an Outpatient Drug Abuse Treatment Center.

    PubMed

    Vallecillo, Gabriel; Mojal, Sergio; Roquer, Albert; Samos, Pilar; Luque, Sonia; Martinez, Diana; Martires, Paula Karen; Torrens, Marta

    2016-05-01

    Continuous HIV treatment is necessary to ensure successful combined antiretroviral therapy (cART). The aim of this study was to evaluate the incidence of patient-initiated non-structured treatment interruptions in HIV-infected persons who inject drugs and who received a multidisciplinary comprehensive program, including medical HIV care, drug-dependence treatment and psychosocial support, at a drug outpatient addiction center. Non-structured treatment interruptions were defined as ≥30 consecutive days off cART without medical indication. During a median follow-up of 53.8 months, 37/132 (28 %) patients experienced the first non-structured treatment interruptions. The cumulative probability of cART interruption at 5 years was 31.2 % (95 % CI 22.4-40.0). Current drug use injection ≥1/day (HR 14.77; 95 % CI 5.90-36.96) and cART naive patients (HR 0.35, 95 % CI 0.14-0.93) were predictive factors for non-structured treatment interruptions. HIV care provided at a drug addiction center is a useful strategy to sustain continuous cART, however, drug abstinence is essential for the long-term maintenance of cART. PMID:26427376

  4. Growth mechanism of highly uniform InAs/GaAs quantum dot with periodic arsine interruption by metalorganic chemical vapor deposition

    NASA Astrophysics Data System (ADS)

    Kim, Jungsub; Yang, Changjae; Sim, Uk; Lee, Gun-Do; Park, Jinsub; Lee, Youngsoo; Yoon, Euijoon

    2011-08-01

    The mechanism for suppressing the formation of abnormally large islands during the conventional quantum dot (QD) growth was investigated. In comparison of the periodic arsine interruption method to the conventional method, InAs QDs grown on GaAs substrate by metal organic chemical vapor deposition has a higher density and aspect ratio without large islands. The formation of large islands was related to the inhomogeneity in the nucleation and growth process of QDs. The surface modification from As-stabilized to In-stabilized surfaces during arsine interruption modulated the surface energy and resulted in more homogeneous and simultaneous nucleation of QDs. The arsine interruption time was found to be a critical parameter for the homogeneous QD growth without abnormally large islands.

  5. Locally Advanced Stage IV Squamous Cell Carcinoma of the Head and Neck: Impact of Pre-Radiotherapy Hemoglobin Level and Interruptions During Radiotherapy

    SciTech Connect

    Rades, Dirk Stoehr, Monika; Kazic, Nadja; Hakim, Samer G.; Walz, Annette; Schild, Steven E.; Dunst, Juergen

    2008-03-15

    Purpose: Stage IV head and neck cancer patients carry a poor prognosis. Clear understanding of prognostic factors can help to optimize care for the individual patient. This study investigated 11 potential prognostic factors including pre-radiotherapy hemoglobin level and interruptions during radiotherapy for overall survival (OS), metastases-free survival (MFS), and locoregional control (LC) after radiochemotherapy. Methods and Materials: Eleven factors were investigated in 153 patients receiving radiochemotherapy for Stage IV squamous cell head and neck cancer: age, gender, Karnofsky performance score (KPS), tumor site, grading, T stage, N stage, pre-radiotherapy hemoglobin level, surgery, chemotherapy type, and interruptions during radiotherapy >1 week. Results: On multivariate analysis, improved OS was associated with KPS 90-100 (relative risk [RR], 2.36; 95% confidence interval [CI], 1.20-4.93; p = .012), hemoglobin {>=}12 g/dL (RR, 1.88; 95% CI, 1.01-3.53; p = .048), and no radiotherapy interruptions (RR, 2.59; 95% CI, 1.15-5.78; p = .021). Improved LC was significantly associated with lower T stage (RR, 2.17; 95% CI, 1.16-4.63; p = .013), hemoglobin {>=}12 g/dL (RR, 4.12; 95% CI, 1.92-9.09; p < .001), surgery (RR, 2.67; 95% CI, 1.28-5.88; p = .008), and no radiotherapy interruptions (RR, 3.32; 95% CI, 1.26-8.79; p = .015). Improved MFS was associated with KPS 90-100 (RR, 3.41; 95% CI, 1.46-8.85; p = .012). Conclusions: Significant predictors for outcome in Stage IV head and neck cancer were performance status, stage, surgery, pre-radiotherapy hemoglobin level, and interruptions during radiotherapy >1 week. It appears important to avoid anemia and radiotherapy interruptions to achieve the best treatment results.

  6. The interruption of thyroid and interrenal and the inter-hormonal interference in fish: does it promote physiologic adaptation or maladaptation?

    PubMed

    Peter, Valsa S; Peter, M C Subhash

    2011-12-01

    Endocrines, the chief components of chemical centers which produce hormones in tune with intrinsic and extrinsic clues, create a chemical bridge between the organism and the environment. In fishes also hormones integrate and modulate many physiologic functions and its synthesis, release, biological actions and metabolic clearance are well regulated. Consequently, thyroid hormones (THs) and cortisol, the products of thyroid and interrenal axes, have been identified for their common integrative actions on metabolic and osmotic functions in fish. On the other hand, many anthropogenic chemical substances, popularly known as endocrine disrupting chemicals, have been shown to disrupt the hormone-receptor signaling pathways in a number fish species. These chemicals which are known for their ability to induce endocrine disruption particularly on thyroid and interrenals can cause malfunction or maladaptation of many vital processes which are involved in the development, growth and reproduction in fish. On the contrary, evidence is presented that the endocrine interrupting agents (EIAs) can cause interruption of thyroid and interrenals, resulting in physiologic compensatory mechanisms which can be adaptive, though such hormonal interactions are less recognized in fishes. The EIAs of physical, chemical and biological origins can specifically interrupt and modify the hormonal interactions between THs and cortisol, resulting in specific patterns of inter-hormonal interference. The physiologic analysis of these inter-hormonal interruptions during acclimation and post-acclimation to intrinsic or extrinsic EIAs reveals that combinations of anti-hormonal, pro-hormonal or stati-hormonal interference may help the fish to fine-tune their metabolic and osmotic performances as part of physiologic adaptation. This novel hypothesis on the phenomenon of inter-hormonal interference and its consequent physiologic interference during thyroid and interrenal interruption thus forms the basis of

  7. A Novel Surgical Technique for Right-Sided Interrupted Aortic Arch by Interposition of a Pulmonary Autograft Tube.

    PubMed

    Kato, Nobuyasu; Yamagishi, Masaaki; Miyazaki, Takako; Maeda, Yoshinobu; Asada, Satoshi; Hongu, Hisayuki; Yamashita, Eijiro; Yaku, Hitoshi

    2016-08-01

    Right-sided interrupted aortic arch (IAA) is a rare cardiac anomaly. In general, the right bronchus sits higher than the left bronchus, so aortic arch reconstruction with a direct anastomosis has a risk of tracheal and bronchial obstruction. This report describes the successful definitive repair of a right-sided IAA in a 2.5-kg neonate by aortic arch reconstruction with a pulmonary autograft tube (PA tube). Postoperative three-dimensional multidetector computed tomography showed the reconstructed aortic arch without airway obstruction or aortic stenosis. The use of a PA tube is a simple and useful technique for aortic arch reconstruction in patients with a high risk of tracheal andbronchial obstruction, such as right-sided IAA. PMID:27449446

  8. An atomtronic flux qubit: a ring lattice of Bose–Einstein condensates interrupted by three weak links

    NASA Astrophysics Data System (ADS)

    Aghamalyan, D.; Nguyen, N. T.; Auksztol, F.; Gan, K. S.; Martinez Valado, M.; Condylis, P. C.; Kwek, L.-C.; Dumke, R.; Amico, L.

    2016-07-01

    We study a physical system consisting of a Bose–Einstein condensate confined to a ring shaped lattice potential interrupted by three weak links. The system is assumed to be driven by an effective flux piercing the ring lattice. By employing path integral techniques, we explore the effective quantum dynamics of the system in a pure quantum phase dynamics regime. Moreover, the effects of the density’s quantum fluctuations are studied through exact diagonalization analysis of the spectroscopy of the Bose–Hubbard model. We demonstrate that a clear two-level system emerges by tuning the magnetic flux at degeneracy. The lattice confinement, platform for the condensate, is realized experimentally employing a spatial light modulator.

  9. Ebselen and congeners inhibit NADPH-oxidase 2 (Nox2)-dependent superoxide generation by interrupting the binding of regulatory subunits

    PubMed Central

    Smith, Susan M.E.; Min, Jaeki; Ganesh, Thota; Diebold, Becky; Kawahara, Tsukasa; Zhu, Yerun; McCoy, James; Sun, Aiming; Snyder, James P.; Fu, Haian; Du, Yuhong; Lewis, Iestyn; Lambeth, J. David

    2012-01-01

    Summary NADPH-oxidases are a primary source of reactive oxygen species (ROS), which function in normal physiology and, when overproduced, in pathophysiology. Recent studies using mice deficient in Nox2 identify this isoform as a novel target against Nox2-implicated inflammatory diseases. Nox2 activation depends on the binding of the proline rich domain of its heterodimeric partner p22phox to p47phox. A high-throughput screen that monitored this interaction via fluorescence polarization identified ebselen and several of its analogs as inhibitors. Medicinal chemistry was performed to explore structure-activity relationships and to optimize potency. Ebselen and analogs potently inhibited Nox1 and Nox2 activity but were less effective against other isoforms. Ebselen also blocked translocation of p47phox to neutrophil membranes. Thus, ebselen and its analogs represent a class of compounds that inhibit ROS generation by interrupting the assembly of Nox2-activating regulatory subunits. PMID:22726689

  10. Internet-based remote counseling to support stress management: preventing interruptions to regular exercise in elderly people

    NASA Astrophysics Data System (ADS)

    Hashimoto, Sayuri; Munakata, Tsunestugu; Hashimoto, Nobuyuki; Okunaka, Jyunzo; Koga, Tatsuzo

    2006-01-01

    Our research showed that a high degree of life-stress has a negative mental health effect that may interrupt regular exercise. We used an internet based, remotely conducted, face to face, preventive counseling program using video monitors to reduce the source of life-stresses that interrupts regular exercise and evaluated the preventative effects of the program in elderly people. NTSC Video signals were converted to the IP protocol and facial images were transmitted to a PC display using the exclusive optical network lines of JGN2. Participants were 22 elderly people in Hokkaido, Japan, who regularly played table tennis. A survey was conducted before the intervention in August 2003. IT remote counseling was conducted on two occasions for one hour on each occasion. A post intervention survey was conducted in February 2004 and a follow-up survey was conducted in March 2005. Network quality was satisfactory with little data loss and high display quality. Results indicated that self-esteem increased significantly, trait anxiety decreased significantly, cognition of emotional support by people other than family members had a tendency to increase, and source of stress had a tendency to decrease after the intervention. Follow-up results indicated that cognition of emotional support by family increased significantly, and interpersonal dependency decreased significantly compared to before the intervention. These results suggest that face to face IT remote counseling using video monitors is useful to keep elderly people from feeling anxious and to make them confident to continue exercising regularly. Moreover, it has a stress management effect.

  11. Gallium-Arsenide Metalorganic Chemical Vapor Deposition with Alkyl Arsenic Sources: Temperature and Gas-Switched Interrupted Growth Interfaces

    NASA Astrophysics Data System (ADS)

    Vook, Dietrich Werner

    A major hindrance to the wide application of Metalorganic Chemical Vapor Deposition (MOCVD) for III-V device fabrication is the toxicity of the group V hydrides, arsine and phosphine. The ability to fabricate structures with composition changes which are arbitrarily abrupt without the use of extremely high flow rates and associated quantities of toxic gasses is also desirable. This work contains an investigation of the growth of GaAs with four different organometallic substitutes for arsine. Decomposition mechanisms for two of these sources are given. A precracking method used to produce the highest quality GaAs layers grown with one of the sources is also given. A major portion of this work examines the interrupted growth interfaces between successive layers of GaAs grown by MOCVD using two fundamentally different layer growth switching methods, both aimed at increasing the interface abruptness. The first technique, which is the conventional gas switching method, controls the growth rate through the supply of the column III precursors. The second method, known as "Limited Reaction Processing", controls the growth kinetically, by changing the substrate temperature quickly. For both cases, the chemical impurities and deep levels at the interfaces are investigated by Secondary Ion Mass Spectroscopy (SIMS) and Deep Level Transient Spectroscopy (DLTS). A method for calculating the sheet trap concentrations from the DLTS data is developed. In general, conventional gas flow switching produces interfaces free of electronic defects under a wider variety of growth conditions than temperature switched growth. Both techniques yield high quality (trap free) interfaces at low GaAs growth rates. For temperature switched growth, the data suggests that there is a direct relationship between the thickness of GaAs deposited at low temperatures during the temperature transients and the sheet trap concentration of electrical defects at the interrupted growth interface. Our results

  12. Pressure support-ventilation versus spontaneous breathing with "T-Tube" for interrupting the ventilation after cardiac operations

    PubMed Central

    Lourenço, Isabela Scali; Franco, Aline Marques; Bassetto, Solange; Rodrigues, Alfredo José

    2013-01-01

    Objective To compare pressure-support ventilation with spontaneous breathing through a T-tube for interrupting invasive mechanical ventilation in patients undergoing cardiac surgery with cardiopulmonary bypass. Methods Adults of both genders were randomly allocated to 30 minutes of either pressure-support ventilation or spontaneous ventilation with "T-tube" before extubation. Manovacuometry, ventilometry and clinical evaluation were performed before the operation, immediately before and after extubation, 1h and 12h after extubation. Results Twenty-eight patients were studied. There were no deaths or pulmonary complications. The mean aortic clamping time in the pressure support ventilation group was 62 ± 35 minutes and 68 ± 36 minutes in the T-tube group (P=0.651). The mean cardiopulmonary bypass duration in the pressure-support ventilation group was 89 ± 44 minutes and 82 ± 42 minutes in the T-tube group (P=0.75). The mean Tobin index in the pressure support ventilation group was 51 ± 25 and 64.5 ± 23 in the T-tube group (P=0.153). The duration of intensive care unit stay for the pressure support ventilation group was 2.1 ± 0.36 days and 2.3 ± 0.61 days in the T-tube group (P=0.581). The atelectasis score in the T-tube group was 0.6 ± 0.8 and 0.5 ± 0.6 (P=0.979) in the pressure support ventilation group. The study groups did not differ significantly in manovacuometric and ventilometric parameters and hospital evolution. Conclusion The two trial methods evaluated for interruption of mechanical ventilation did not affect the postoperative course of patients who underwent cardiac operations with cardiopulmonary bypass. PMID:24598949

  13. Correlates of unstructured antiretroviral treatment interruption in a cohort of HIV-positive individuals in British Columbia.

    PubMed

    Samji, Hasina; Chen, Yalin; Salters, Kate; Montaner, Julio S G; Hogg, Robert S

    2014-11-01

    Treatment interruptions (TIs) limit the therapeutic success of combination antiretroviral therapy and are associated with higher morbidity and mortality. HIV-positive individuals dealing with concurrent health issues, access challenges and competing life demands are hypothesized to be more likely to interrupt treatment. Individuals were included if they initiated cART ≥1 year prior to interview date and had a CD4 cell count and initial regimen recorded at initiation. Using pharmacy recording, a TI was defined as a patient-initiated gap in treatment ≥90 consecutive days during the 12 months preceding or following the study interview. 117 (15.2 %) of 768 participants included in this study had a TI during the study window. 76.0 % of participants were male, 27.5 % were of Aboriginal ancestry and the median age was 46 (interquartile range 40-52). In multivariable logistic regression, TIs were significantly associated with current illicit drug use (adjusted odds ratio [aOR] 1.68, 95 % confidence interval [CI] 1.05-2.68); <95 % adherence in the first year of treatment (aOR 2.68, 95 % CI 1.67-4.12); living with at least one person (aOR 1.95; 95 % CI 1.22-3.14) or living on the street (aOR 5.08, 95 % CI 1.72-14.99) compared to living alone; poor perception of overall health (aOR 1.64 95 % CI 1.05-2.55); being unemployed (aOR: 2.22, 95 % CI 1.16-4.23); and younger age at interview (aOR 0.57, 95 % CI 0.44-0.75, per 10 year increase). Addressing socioeconomic barriers to treatment retention is vital for supporting the continuous engagement of patients in care. PMID:24781638

  14. Laboratory studies of the effects of interrupted, sloping topography on intermediate depth boundary currents in linearly stratified fluids

    NASA Astrophysics Data System (ADS)

    Folkard, Andrew M.; Davies, Peter A.

    2001-05-01

    Laboratory experiments are described which provide insight into the interaction of intermediate depth boundary currents (IDBCs) with interrupted sloping topography. Specifically, they contribute to the debate over meddy formation on the Iberian continental slope. The experiments were performed in a rectilinear rotating tank filled initially with a linearly-stratified fluid. A false bottom sloped away from the side-wall along which the current flowed, and was interrupted by a gap of variable length. The effects of varying gap length and rotation rate on the boundary current were observed. In the first of two sets of experiments, the current flowed above the slope, along the vertical sidewall. In the second, the current flowed along the sloping bottom. In the former, current nose speed was consistent with geostrophic predictions, but decreased in the presence of a gap in the topography. Kelvin wave radiation is postulated as a reason for this. The IDBCs exhibited vortical lateral intrusions at values of the Burger number Bu=(N 0/Ω) 2 at which counterpart flat-bottom studies had been stable, implying that the sloping topography had a de-stabilising effect. Energy measurements and qualitative observations suggest the intrusions were due to mixed barotropic/baroclinic instabilities, the latter dominating at higher rotation rates. In the second configuration, four distinct flows were observed, distinguished by the deformation radius:gap width ratio RD/ G∗. For a range of values of RD/ G∗, attached eddies formed at the upstream end of the gap. They remained at this position, unlike those in similar studies of surface boundary currents ( Klinger, 1993). Their persistence and ability to move downstream - salient factors for meddy - formation were greater for a finite gap size than a permanent change from sloping to flat bottom.

  15. Effects of energy distribution of interface traps on recombination dc current-voltage line shape

    NASA Astrophysics Data System (ADS)

    Chen, Zuhui; Jie, Bin B.; Sah, Chih-Tang

    2006-12-01

    The effects of energy distributions of Si /SiO2 interface traps in the energy gap of oxidized silicon on the current versus voltage line shape of the electron-hole recombination current are analyzed using the steady-state Shockley-Read-Hall kinetics. Slater's [Insulators, Semiconductors and Metals; Quantum Theory of Molecules and Solids (McGraw-Hill, New York, 1967)] localized bulk perturbation theory applied by us to the interface anticipates U-shaped energy distributions of the density of neutral electron and hole interface traps from random variations of the Si:Si and Si:O bond angles and lengths. Conservation in dissipative transition energy anticipates the rate of electron capture into neutral electron trap to be faster for electron trap energy levels nearer the conduction band edge, and similarly, the rate of hole capture into neutral hole trap to be faster for hole trap energy levels nearer the valence band edge. Line shape broadening is analyzed for discrete and U-shaped energy distributions of interface trap energy levels. The broadened line shapes observed in past experiments, previously attributed to spatial variations of surface dopant impurity concentrations, could also arise from energy distributions of interface trap energy levels.

  16. Negative huge magnetoresistance in high-mobility 2D electron gases: DC-current dependence

    NASA Astrophysics Data System (ADS)

    Iñarrea, J.; Bockhorn, L.; Haug, R. J.

    2016-07-01

    Two-dimensional electron gases with very high mobility show a huge or giant negative magnetoresistance at low temperatures and low magnetic fields. We present an experimental and theoretical work on the influence of the applied current on the negative huge magnetoresistance of these systems. We obtain an unexpected and strong nonlinear behavior consisting in an increase of the negative huge magnetoresistance with increasing current, in other words, for increasing current the magnetoresistance collapses at small magnetic fields. This nonlinearity is explained by the subtle interplay of elastic scattering within Landau levels and between Landau levels.

  17. The Impact of Interrupted Use of a Speech Generating Device on the Communication Acts of a Child with Autism Spectrum Disorder: A Case Study

    ERIC Educational Resources Information Center

    Neeley, Richard A.; Pulliam, Mary Hannah; Catt, Merrill; McDaniel, D. Mike

    2015-01-01

    This case study examined the initial and renewed impact of speech generating devices on the expressive communication behaviors of a child with autism spectrum disorder. The study spanned six years of interrupted use of two speech generating devices. The child's communication behaviors were analyzed from video recordings and included communication…

  18. The effect of high temperature interruptions during inductive period on the extent of flowering and on metabolic responses in olives (Olea europaea L.)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The effect of the duration of high temperature interruption and the timing of it’s occurrence during inductive period on the extent of inhibition of inflorescence production in ‘Arbequina’ olive trees was investigated. Trees kept under inductive conditions in different growth chambers were subjected...

  19. 41 CFR 301-70.506 - How do we define actual cost and constructive cost when an employee interrupts a travel...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 41 Public Contracts and Property Management 4 2012-07-01 2012-07-01 false How do we define actual cost and constructive cost when an employee interrupts a travel assignment because of an incapacitating illness or injury? 301-70.506 Section 301-70.506 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY...

  20. An Interrupted Time Series Analysis of the State College Nuisance Property Ordinance and an Assessment of Rental Property Managers as Place Manager/Intimate Handler of Offender

    ERIC Educational Resources Information Center

    Koehle, Gregory M.

    2011-01-01

    This research involves a legal impact study of the State College Nuisance Property Ordinance and an assessment of State College Rental Property Managers in the role of place manager/intimate handler of offender. The impact of the Ordinance was assessed by employing an interrupted time series design which examined five years of pre-ordinance…

  1. The Use of Piecewise Growth Models to Estimate Learning Trajectories and RtI Instructional Effects in a Comparative Interrupted Time-Series Design

    ERIC Educational Resources Information Center

    Zvoch, Keith

    2016-01-01

    Piecewise growth models (PGMs) were used to estimate and model changes in the preliteracy skill development of kindergartners in a moderately sized school district in the Pacific Northwest. PGMs were applied to interrupted time-series (ITS) data that arose within the context of a response-to-intervention (RtI) instructional framework. During the…

  2. 47 CFR 64.1507 - Prohibition on disconnection or interruption of service for failure to remit pay-per-call and...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... service for failure to remit pay-per-call and similar service charges. 64.1507 Section 64.1507... RULES RELATING TO COMMON CARRIERS Interstate Pay-Per-Call and Other Information Services § 64.1507 Prohibition on disconnection or interruption of service for failure to remit pay-per-call and similar...

  3. Peek-a-What? Infants' Response to the Still-Face Task after Normal and Interrupted Peek-a-Boo

    ERIC Educational Resources Information Center

    Bigelow, Ann E.; Best, Caitlin

    2013-01-01

    Infants' sensitivity to the vitality or tension envelope within dyadic social exchanges was investigated by examining their responses following normal and interrupted games of peek-a-boo embedded in a Still-Face Task. Infants 5-6 months old engaged in two modified Still-Face Tasks with their mothers. In one task, the initial interaction ended…

  4. Interruption of the semiochemical-based attraction of ambrosia beetles to ethanol-baited traps and ethanol-injected trap trees by Verbenone

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We examined the ability of verbenone, a bark beetle anti-aggregation pheromone, to interrupt the semiochemical-based attraction of ambrosia beetles. Field trapping studies conducted in Ohio showed that a verbenone dispenser with a release rate of 50 mg / d at 25 oC reduced the attraction of Anisandr...

  5. Health Care Financing Administration--conditions for coverage of suppliers of ESRD services; revocation of requirements for emergency generator and ground fault interrupters. Final rule.

    PubMed

    1980-04-10

    These amendments remove the requirements for emergency generators and ground fault interrupters in end-stage renal dialysis (ESRD) facilities. The purpose is to reduce unnecessary and burdensome requirements which are not necessary to the health and safety of patients. PMID:10246083

  6. Honoring Counterstories: Utilizing Digital Storytelling in the Culturally Responsive Classroom to Investigate the Community Cultural Wealth and Resiliency of Students with Limited or Interrupted Formal Education (SLIFE)

    ERIC Educational Resources Information Center

    Porter, Christina M.

    2013-01-01

    This ethnography seeks to identify the strengths that students with limited or interrupted formal education (SLIFE), a unique subpopulation of English Language Learners (ELLs), possess and explore how those strengths may be utilized in the secondary classroom. This research aims to shift the focus from "eliminating deficits" to working…

  7. Interrupted Incubation and Short-Term Storage of the Alfalfa Pollinator, Megachile rotundata (Hymenoptera: Megachilidae): A Potential Tool for Synchronizing Bees With Bloom

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Interrupting the spring incubation with short-term low temperature storage of the developing pupae and pharate adult stage of Megachile rotundata (F.) is a useful technique for synchronizing the emergence of this bee species with the peak alfalfa bloom. However, low temperature exposure can be stres...

  8. The Validity and Precision of the Comparative Interrupted Time Series Design and the Difference-in-Difference Design in Educational Evaluation

    ERIC Educational Resources Information Center

    Somers, Marie-Andrée; Zhu, Pei; Jacob, Robin; Bloom, Howard

    2013-01-01

    In this paper, we examine the validity and precision of two nonexperimental study designs (NXDs) that can be used in educational evaluation: the comparative interrupted time series (CITS) design and the difference-in-difference (DD) design. In a CITS design, program impacts are evaluated by looking at whether the treatment group deviates from its…

  9. Influence of apheresis container size on the maintenance of platelet in vitro storage properties after a 30-h interruption of agitation.

    PubMed

    Wagner, Stephen J; Skripchenko, Andrey; Seetharaman, Shalini; Myrup, Andrew; Kurtz, James; Thomas-Montgomery, Dedeene; Awatefe, Helen; Moroff, Gary

    2010-08-01

    We have previously conducted studies investigating maintenance of apheresis platelet in vitro quality measures during storage under simulated shipping conditions in which agitation was interrupted. This study examines the effect of increasing bag surface area on the preservation of in vitro platelet properties during storage with continuous agitation and with a 30 h interruption of agitation. Apheresis platelets were collected in 100% plasma with the Amicus separator to provide two identical platelet products, each with approximately 4-5 x 10(11) platelets. After collection, the volume was divided equally between 1.0 and 1.3 L PL2410 containers. In an initial study, both products were continuously agitated. In a second study, both products were subjected to a single 30-h period of interrupted agitation between Days 2 and 3 of storage by placement in a standard shipping box at room temperature. In each study, units were assayed during storage for standard in vitro platelet quality measures. Platelets stored in the 1.3 L container maintained slightly greater mean pH during 7 day storage with either continuous agitation (n=6) or with a 30-h interruption of agitation (n=12) than those of similarly treated identical platelets stored in the 1.0 L container. Most noteworthy, in experiments with products stored in the 1.0 L container in which there was a large decrease in pH to levels <6.7 or <6.3 on days 5 or 7, respectively, the pH in the matched product stored in the 1.3 L container was substantially greater (0.17+/-06 and 0.37+/-0.09 pH units greater, n=4, respectively). Other measures showed either small differences or comparability of platelet in vitro parameters with storage in the two containers after an interruption of agitation. PMID:20554476

  10. Morphogenesis, Flowering, and Gene Expression of Dendranthema grandiflorum in Response to Shift in Light Quality of Night Interruption.

    PubMed

    Park, Yoo Gyeong; Muneer, Sowbiya; Jeong, Byoung Ryong

    2015-01-01

    The impact of shifts in the spectral quality of light on morphogenesis, flowering, and photoperiodic gene expression during exposure to light quality of night interruption (NI) was investigated in Dendranthema grandiflorum. The circadian rhythms of plants grown in a closed walk-in growth chamber were interrupted at night for a total of 4 h, using light-emitting diodes with an intensity of 10 μmol·m⁻²·s⁻¹ PPF. The light quality of the NI was shifted from one wavelength to another after the first 2 h. Light treatments consisting of all possible pairings of blue (B), red (R), far-red (Fr), and white (W) light were tested. Plants in the NI treatment groups exposed to Fr light grew larger than plants in other treatment groups. Of plants in NI treatment groups, those in the NI-WB treatment grew the least. In addition, the impact of shifts in the light quality of NI on leaf expansion was greater in treatment groups exposed to a combination of either B and R or R and W light, regardless of their order of supply. Flowering was observed in the NI-RB, NI-FrR, NI-BFr, NI-FrB, NI-WB, NI-FrW, NI-WFr, NI-WR, and SD (short-day) treatments, and was especially promoted in the NI-BFr and NI-FrB treatments. In a combined shift treatment of B and R or B and W light, the NI concluded with B light (NI-RB and NI-WB) treatment induced flowering. The transcriptional factors phyA, cry1 and FTL (FLOWERING LOCUS T) were positively affected, while phyB and AFT were negatively affected. In conclusion, morphogenesis, flowering, and transcriptional factors were all significantly affected either positively or negatively by shifts in the light quality of NI. The light quality of the first 2 h of NI affected neither morphogenesis nor flowering, while the light quality of the last 2 h of NI significantly affected both morphogenesis and flowering. PMID:26197314

  11. Understanding reasons for treatment interruption amongst patients on antiretroviral therapy – A qualitative study at the Lighthouse Clinic, Lilongwe, Malawi

    PubMed Central

    Tabatabai, Julia; Namakhoma, Ireen; Tweya, Hannock; Phiri, Sam; Schnitzler, Paul; Neuhann, Florian

    2014-01-01

    Background In recent years, scaling up of antiretroviral therapy (ART) in resource-limited settings moved impressively towards universal access. Along with these achievements, public health HIV programs are facing a number of challenges including the support of patients on lifelong therapy and the prevention of temporary/permanent loss of patients in care. Understanding reasons for treatment interruption (TI) can inform strategies for improving drug adherence and retention in care. Objective To evaluate key characteristics of patients resuming ART after TI at the Lighthouse Clinic in Lilongwe, Malawi, and to identify their reasons for interrupting ART. Design This study uses a mixed methods design to evaluate patients resuming ART after TI. We analysed an assessment form for patients with TI using pre-defined categories and a comments field to identify frequently stated reasons for TI. Additionally, we conducted 26 in-depth interviews to deepen our understanding of common reasons for TI. In-depth interviews also included the patients’ knowledge about ART and presence of social support systems. Qualitative data analysis was based on a thematic framework approach. Results A total of 347 patients (58.2% female, average age 35.1±11.3 years) with TI were identified. Despite the presence of social support and sufficient knowledge of possible consequences of TI, all patients experienced situations that resulted in TI. Analysis of in-depth interviews led to new and distinct categories for TI. The most common reason for TI was travel (54.5%, n=80/147), which further differentiated into work- or family-related travel. Patients also stated transport costs and health-care-provider-related reasons, which included perceived/enacted discrimination by health care workers. Other drivers of TI were treatment fatigue/forgetfulness, the patients’ health status, adverse drug effects, pregnancy/delivery, religious belief or perceived/enacted stigma. Conclusions To adequately

  12. Morphogenesis, Flowering, and Gene Expression of Dendranthema grandiflorum in Response to Shift in Light Quality of Night Interruption

    PubMed Central

    Park, Yoo Gyeong; Muneer, Sowbiya; Jeong, Byoung Ryong

    2015-01-01

    The impact of shifts in the spectral quality of light on morphogenesis, flowering, and photoperiodic gene expression during exposure to light quality of night interruption (NI) was investigated in Dendranthema grandiflorum. The circadian rhythms of plants grown in a closed walk-in growth chamber were interrupted at night for a total of 4 h, using light-emitting diodes with an intensity of 10 μmol·m−2·s−1 PPF. The light quality of the NI was shifted from one wavelength to another after the first 2 h. Light treatments consisting of all possible pairings of blue (B), red (R), far-red (Fr), and white (W) light were tested. Plants in the NI treatment groups exposed to Fr light grew larger than plants in other treatment groups. Of plants in NI treatment groups, those in the NI-WB treatment grew the least. In addition, the impact of shifts in the light quality of NI on leaf expansion was greater in treatment groups exposed to a combination of either B and R or R and W light, regardless of their order of supply. Flowering was observed in the NI-RB, NI-FrR, NI-BFr, NI-FrB, NI-WB, NI-FrW, NI-WFr, NI-WR, and SD (short-day) treatments, and was especially promoted in the NI-BFr and NI-FrB treatments. In a combined shift treatment of B and R or B and W light, the NI concluded with B light (NI-RB and NI-WB) treatment induced flowering. The transcriptional factors phyA, cry1 and FTL (FLOWERING LOCUS T) were positively affected, while phyB and AFT were negatively affected. In conclusion, morphogenesis, flowering, and transcriptional factors were all significantly affected either positively or negatively by shifts in the light quality of NI. The light quality of the first 2 h of NI affected neither morphogenesis nor flowering, while the light quality of the last 2 h of NI significantly affected both morphogenesis and flowering. PMID:26197314

  13. Chagas disease: current epidemiological trends after the interruption of vectorial and transfusional transmission in the Southern Cone countries.

    PubMed

    Moncayo, Alvaro

    2003-07-01

    Chagas disease, named after Carlos Chagas who first described it in 1909, exists only on the American Continent. It is caused by a parasite, Trypanosoma cruzi, transmitted to humans by blood-sucking triatomine bugs and by blood transfusion. Chagas disease has two successive phases, acute and chronic. The acute phase lasts 6 to 8 weeks. After several years of starting the chronic phase, 20% to 35% of the infected individuals, depending on the geographical area will develop irreversible lesions of the autonomous nervous system in the heart, esophagus, colon and the peripheral nervous system. Data on the prevalence and distribution of Chagas disease improved in quality during the 1980's as a result of the demographically representative cross-sectional studies carried out in countries where accurate information was not available. A group of experts met in Bras lia in 1979 and devised standard protocols to carry out countrywide prevalence studies on human T. cruzi infection and triatomine house infestation. Thanks to a coordinated multi-country program in the Southern Cone countries the transmission of Chagas disease by vectors and by blood transfusion has been interrupted in Uruguay in1997, in Chile in 1999, and in 8 of the 12 endemic states of Brazil in 2000 and so the incidence of new infections by T. cruzi in the whole continent has decreased by 70%. Similar control multi-country initiatives have been launched in the Andean countries and in Central America and rapid progress has been recorded to ensure the interruption of the transmission of Chagas disease by 2005 as requested by a Resolution of the World Health Assembly approved in 1998. The cost-benefit analysis of the investments of the vector control program in Brazil indicate that there are savings of US$17 in medical care and disabilities for each dollar spent on prevention, showing that the program is a health investment with good return. Since the inception in 1979 of the Steering Committee on Chagas Disease

  14. Novel X-linked glomerulopathy associated with a COL4A5 missense mutation in a noncollagenous interruption

    PubMed Central

    Becknell, Brian; Zender, Gloria; Houston, Ronald; Baker, Peter; McBride, Kim L.; Luo, Wentian; Hains, David; Borza, Dorin-Bogdan; Schwaderer, Andrew L.

    2011-01-01

    We report a novel COL4A5 mutation causing rapid progression to end stage renal disease in males despite the absence of clinical and biopsy findings associated with Alport syndrome. Affected males had proteinuria, variable hematuria, early progression to end stage renal disease; and renal biopsy findings which included global and segmental glomerulosclerosis, mesangial hypercellularity and basement membrane immune complex deposition. Exon sequencing of the COL4A5 locus identified a thymine to guanine transversion at nucleotide 665, resulting in a phenylalanine to cysteine missense mutation at codon 222. This mutation was confirmed in 4 affected males and 4 female obligate carriers, but was absent in 6 asymptomatic male family members and 198 unrelated individuals. α5(IV) collagen staining in renal biopsies from affected males was normal. The phenylalanine at position 222 is 100% conserved among vertebrates. This is the first description of a mutation in a non-collagenous interruption associated with severe renal disease, providing evidence for the importance of this structural motif. The range of phenotypes associated with COL4A5 mutations is more diverse than previously realized. COL4A5 mutation analysis should be considered when glomerulonephritis presents in an X-linked inheritance pattern, even with a distinct presentation from Alport syndrome. PMID:20881942

  15. Pituitary Stalk Interruption Syndrome from Infancy to Adulthood: Clinical, Hormonal, and Radiological Assessment According to the Initial Presentation

    PubMed Central

    Bar, Céline; Zadro, Charline; Diene, Gwenaelle; Oliver, Isabelle; Pienkowski, Catherine; Jouret, Béatrice; Cartault, Audrey; Ajaltouni, Zeina; Salles, Jean-Pierre; Sevely, Annick; Tauber, Maithé; Edouard, Thomas

    2015-01-01

    Background Patients with pituitary stalk interruption syndrome (PSIS) are initially referred for hypoglycemia during the neonatal period or growth retardation during childhood. PSIS is either isolated (nonsyndromic) or associated with extra-pituitary malformations (syndromic). Objective To compare baseline characteristics and long-term evolution in patients with PSIS according to the initial presentation. Study Design Sixty-seven patients with PSIS were included. Data from subgroups were compared: neonates (n = 10) versus growth retardation patients (n = 47), and syndromic (n = 32) versus nonsyndromic patients (n = 35). Results Neonates displayed a more severe hormonal and radiological phenotype than children referred for growth retardation, with a higher incidence of multiple hormonal deficiencies (100% versus 34%; P = 0.0005) and a nonvisible anterior pituitary lobe (33% versus 2%; P = 0.0017). Regular follow-up of growth might have allowed earlier diagnosis in the children with growth retardation, as decreased growth velocity and growth retardation were present respectively 3 and 2 years before referral. We documented a progressive worsening of endocrine impairment throughout childhood in these patients. Presence of extra-pituitary malformations (found in 48%) was not associated with more severe hormonal and radiological characteristics. Growth under GH treatment was similar in the patient groups and did not vary according to the pituitary MRI findings. Conclusions PSIS diagnosed in the neonatal period has a particularly severe hormonal and radiological phenotype. The progressive worsening of endocrine impairment throughout childhood justifies periodic follow-up to check for additional hormonal deficiencies. PMID:26562670

  16. Sentence intelligibility during segmental interruption and masking by speech-modulated noise: Effects of age and hearing loss.

    PubMed

    Fogerty, Daniel; Ahlstrom, Jayne B; Bologna, William J; Dubno, Judy R

    2015-06-01

    This study investigated how single-talker modulated noise impacts consonant and vowel cues to sentence intelligibility. Younger normal-hearing, older normal-hearing, and older hearing-impaired listeners completed speech recognition tests. All listeners received spectrally shaped speech matched to their individual audiometric thresholds to ensure sufficient audibility with the exception of a second younger listener group who received spectral shaping that matched the mean audiogram of the hearing-impaired listeners. Results demonstrated minimal declines in intelligibility for older listeners with normal hearing and more evident declines for older hearing-impaired listeners, possibly related to impaired temporal processing. A correlational analysis suggests a common underlying ability to process information during vowels that is predictive of speech-in-modulated noise abilities. Whereas, the ability to use consonant cues appears specific to the particular characteristics of the noise and interruption. Performance declines for older listeners were mostly confined to consonant conditions. Spectral shaping accounted for the primary contributions of audibility. However, comparison with the young spectral controls who received identical spectral shaping suggests that this procedure may reduce wideband temporal modulation cues due to frequency-specific amplification that affected high-frequency consonants more than low-frequency vowels. These spectral changes may impact speech intelligibility in certain modulation masking conditions. PMID:26093436

  17. An Interrupted Time-Series Analysis of Durkheim's Social Deregulation Thesis: The Case of the Russian Federation

    PubMed Central

    Pridemore, William Alex; Chamlin, Mitchell B.; Cochran, John K.

    2009-01-01

    The dissolution of the Soviet Union resulted in sudden, widespread, and fundamental changes to Russian society. The former social welfare system-with its broad guarantees of employment, healthcare, education, and other forms of social support-was dismantled in the shift toward democracy, rule of law, and a free-market economy. This unique natural experiment provides a rare opportunity to examine the potentially disintegrative effects of rapid social change on deviance, and thus to evaluate one of Durkheim's core tenets. We took advantage of this opportunity by performing interrupted time-series analyses of annual age-adjusted homicide, suicide, and alcohol-related mortality rates for the Russian Federation using data from 1956 to 2002, with 1992-2002 as the postintervention time-frame. The ARIMA models indicate that, controlling for the long-term processes that generated these three time series, the breakup of the Soviet Union was associated with an appreciable increase in each of the cause-of-death rates. We interpret these findings as being consistent with the Durkheimian hypothesis that rapid social change disrupts social order, thereby increasing the level of crime and deviance. PMID:20165565

  18. On migration of primary/peritectic interface during interrupted directional solidification of Sn-Ni peritectic alloy.

    PubMed

    Peng, Peng; Li, Xinzhong; Li, Jiangong; Su, Yanqing; Guo, Jingjie; Fu, Hengzhi

    2016-01-01

    The migration of the primary/peritectic interface in local isothermal condition is observed in dendritic structure of Sn-Ni peritectic alloy after experiencing interrupted directional solidification. It was observed that this migration of primary Ni3Sn2/peritectic Ni3Sn4 interface towards the primary Ni3Sn2 phase was accompanied by migration of liquid film located at this interface. The migration velocity of this interface was confirmed to be much faster than that of peritectic transformation, so this migration was mostly caused by superheating of primary Ni3Sn2 phase below TP, leading to nucleation and migration of liquid film at this interface. This migration can be classified as a kind of liquid film migration (LFM), and the migration velocity at the horizontal direction has been confirmed to be much faster than that along the direction of temperature gradient. Analytical prediction has shown that the migration of liquid film could be divided into two stages depending on whether primary phase exists below TP. If the isothermal annealing time is not long enough, both the liquid film and the primary/peritectic interface migrate towards the primary phase until the superheated primary phase has all been dissolved. Then, this migration process towards higher temperature is controlled by temperature gradient zone melting (TGZM). PMID:27075006

  19. Design and implementation of embedded un-interruptible power supply system (EUPSS) for web-based mobile application

    NASA Astrophysics Data System (ADS)

    Zhang, De-gan; Zhang, Xiao-dan

    2012-11-01

    With the growth of the amount of information manipulated by embedded application systems, which are embedded into devices and offer access to the devices on the internet, the requirements of saving the information systemically is necessary so as to fulfil access from the client and the local processing more efficiently. For supporting mobile applications, a design and implementation solution of embedded un-interruptible power supply (UPS) system (in brief, EUPSS) is brought forward for long-distance monitoring and controlling of UPS based on Web. The implementation of system is based on ATmega161, RTL8019AS and Arm chips with TCP/IP protocol suite for communication. In the embedded UPS system, an embedded file system is designed and implemented which saves the data and index information on a serial EEPROM chip in a structured way and communicates with a microcontroller unit through I2C bus. By embedding the file system into UPS system or other information appliances, users can access and manipulate local data on the web client side. Embedded file system on chips will play a major role in the growth of IP networking. Based on our experiment tests, the mobile users can easily monitor and control UPS in different places of long-distance. The performance of EUPSS has satisfied the requirements of all kinds of Web-based mobile applications.

  20. Sentence intelligibility during segmental interruption and masking by speech-modulated noise: Effects of age and hearing loss

    PubMed Central

    Fogerty, Daniel; Ahlstrom, Jayne B.; Bologna, William J.; Dubno, Judy R.

    2015-01-01

    This study investigated how single-talker modulated noise impacts consonant and vowel cues to sentence intelligibility. Younger normal-hearing, older normal-hearing, and older hearing-impaired listeners completed speech recognition tests. All listeners received spectrally shaped speech matched to their individual audiometric thresholds to ensure sufficient audibility with the exception of a second younger listener group who received spectral shaping that matched the mean audiogram of the hearing-impaired listeners. Results demonstrated minimal declines in intelligibility for older listeners with normal hearing and more evident declines for older hearing-impaired listeners, possibly related to impaired temporal processing. A correlational analysis suggests a common underlying ability to process information during vowels that is predictive of speech-in-modulated noise abilities. Whereas, the ability to use consonant cues appears specific to the particular characteristics of the noise and interruption. Performance declines for older listeners were mostly confined to consonant conditions. Spectral shaping accounted for the primary contributions of audibility. However, comparison with the young spectral controls who received identical spectral shaping suggests that this procedure may reduce wideband temporal modulation cues due to frequency-specific amplification that affected high-frequency consonants more than low-frequency vowels. These spectral changes may impact speech intelligibility in certain modulation masking conditions. PMID:26093436

  1. The impact of public transportation strikes on use of a bicycle share program in London: interrupted time series design

    PubMed Central

    2013-01-01

    Objective To investigate the immediate and sustained effects of two London Underground strikes on use of a public bicycle share program. Methods An interrupted time series design was used to examine the impact of two 24 hour strikes on the total number of trips per day and mean trip duration per day on the London public bicycle share program. The strikes occurred on September 6th and October 4th 2010 and limited service on the London Underground. Results The mean total number of trips per day over the whole study period was 14699 (SD=5390) while the mean trip duration was 18.5 minutes (SD=3.7). Significant increases in daily trip rate were observed following strike 1 (3864: 95% CI 125 to 7604) and strike 2 (11293: 95% CI 5169 to 17416). Conclusions Brief interventions that greatly constrain the primary motorised mode of transportation for a population may have short-term effects on travel behaviour. Repeated brief interventions at frequent intervals could contribute to increasing population levels of physical activity by promoting the use of active modes of transportation. PMID:22024219

  2. Influences of Cross-Border Mobility on Tuberculosis Diagnoses and Treatment Interruption Among Injection Drug Users in Tijuana, Mexico

    PubMed Central

    Deiss, Robert; Garfein, Richard S.; Lozada, Remedios; Burgos, Jose Luis; Brouwer, Kimberly C.; Moser, Kathleen S.; Zuniga, Maria Luisa; Rodwell, Timothy C.; Ojeda, Victoria D.

    2009-01-01

    Objectives. We sought to identify correlates of reported lifetime diagnoses of TB among injection drug users in the border city of Tijuana, Mexico. Methods. Injection drug users in Tijuana were recruited into a prospective cohort study during 2006 and 2007. We used weighted multivariate logistic regression to identify correlates of TB diagnoses. Results. Of the 1056 participants, 103 (9.8%) reported a history of TB, among whom 93% received anti-TB medication and 80% were diagnosed in the United States. Treatment was prematurely halted among 8% of patients; deportation from the United States was the cause of half of these treatment interruptions. History of travel to (odds ratio [OR] = 6.44; 95% confidence interval [CI] = 1.53, 27.20) or deportation from (OR = 1.83; 95% CI = 1.07, 3.12) the United States and incarceration (OR = 2.20; 95% CI = 1.06, 4.58) were independently associated with a reported lifetime diagnosis of TB. Conclusions. Mobility and migration are important factors in identifying and treating TB patients diagnosed in the US–Mexico border region. Strengthening capacity on both sides of the border to identify, monitor, and treat TB is a priority. PMID:19542040

  3. Hosed vs. unhosed: global response to interruptions of the Atlantic Meridional Overturning, with and without freshwater forcing

    NASA Astrophysics Data System (ADS)

    Brown, N.; Galbraith, E. D.

    2015-10-01

    It is well known that glacial periods were punctuated by abrupt climate changes, with large impacts on air temperature, precipitation, and ocean circulation across the globe. However, the long-held idea that freshwater forcing, caused by massive iceberg discharges, was the driving force behind these changes has been questioned in recent years. This throws into doubt the abundant literature on modelling abrupt climate change through "hosing" experiments, whereby the Atlantic Meridional Overturning Circulation (AMOC) is interrupted by an injection of freshwater to the North Atlantic: if some, or all, abrupt climate change was not driven by freshwater input, could its character have been very different than the typical hosed experiments? Here, we take advantage of a global coupled ocean-atmosphere model that exhibits spontaneous, unhosed oscillations in AMOC strength, in order to examine how the global imprint of AMOC variations depends on whether or not it is the result of external freshwater input. The results imply that, to first order, the ocean-ice-atmosphere dynamics associated with an AMOC weakening dominate the global response, regardless of whether or not freshwater input is the cause. The exception lies in the impact freshwater inputs can have on the strength of other polar haloclines, particularly the Southern Ocean, to which freshwater can be transported relatively quickly after injection in the North Atlantic.

  4. Current interruption and particle beam generation by a plasma focus. Interim report (annual), 30 Sep 81-30 Sep 82

    SciTech Connect

    Gerdin, G.; Venneri, F.

    1982-11-30

    Through collaboration with Dr. K. H. Schoenbach of Texas Tech University the plasma focus opening switch (PFOS) was revised to answer basic questions as to utility of the concept. To estimate the plasma temperature and classical resistivity a soft X-ray spectrometer and X-ray pinhole camera were developed. The temperature was estimated from a coronal model to range between 0.4 to 0.5 keV for either a nitrogen or neon impurity (1 to 2%) in deuterium at 3 torr. Strong pinches were observed in pure neon (0.6 torr) with an electron temperature in the same range. The corresponding classical resistance of the pinch is 9 m omega whereas 500 m omega is more consistent with output voltage pulse and current flow at interruption indicating anomalous resistivity is present. A one-dimensional two-fluid computer code has been developed to model anomalous resistivity in the pinch phase and preliminary results are consistent with the snowplow model. The final analysis of the plasma focus particle beam generation experiments was completed and a strong correlation was found for the beam-target model as the mechanism for neutron production in the Illinois plasma focus device.

  5. On migration of primary/peritectic interface during interrupted directional solidification of Sn-Ni peritectic alloy

    NASA Astrophysics Data System (ADS)

    Peng, Peng; Li, Xinzhong; Li, Jiangong; Su, Yanqing; Guo, Jingjie; Fu, Hengzhi

    2016-04-01

    The migration of the primary/peritectic interface in local isothermal condition is observed in dendritic structure of Sn–Ni peritectic alloy after experiencing interrupted directional solidification. It was observed that this migration of primary Ni3Sn2/peritectic Ni3Sn4 interface towards the primary Ni3Sn2 phase was accompanied by migration of liquid film located at this interface. The migration velocity of this interface was confirmed to be much faster than that of peritectic transformation, so this migration was mostly caused by superheating of primary Ni3Sn2 phase below TP, leading to nucleation and migration of liquid film at this interface. This migration can be classified as a kind of liquid film migration (LFM), and the migration velocity at the horizontal direction has been confirmed to be much faster than that along the direction of temperature gradient. Analytical prediction has shown that the migration of liquid film could be divided into two stages depending on whether primary phase exists below TP. If the isothermal annealing time is not long enough, both the liquid film and the primary/peritectic interface migrate towards the primary phase until the superheated primary phase has all been dissolved. Then, this migration process towards higher temperature is controlled by temperature gradient zone melting (TGZM).

  6. On migration of primary/peritectic interface during interrupted directional solidification of Sn-Ni peritectic alloy

    PubMed Central

    Peng, Peng; Li, Xinzhong; Li, Jiangong; Su, Yanqing; Guo, Jingjie; Fu, Hengzhi

    2016-01-01

    The migration of the primary/peritectic interface in local isothermal condition is observed in dendritic structure of Sn–Ni peritectic alloy after experiencing interrupted directional solidification. It was observed that this migration of primary Ni3Sn2/peritectic Ni3Sn4 interface towards the primary Ni3Sn2 phase was accompanied by migration of liquid film located at this interface. The migration velocity of this interface was confirmed to be much faster than that of peritectic transformation, so this migration was mostly caused by superheating of primary Ni3Sn2 phase below TP, leading to nucleation and migration of liquid film at this interface. This migration can be classified as a kind of liquid film migration (LFM), and the migration velocity at the horizontal direction has been confirmed to be much faster than that along the direction of temperature gradient. Analytical prediction has shown that the migration of liquid film could be divided into two stages depending on whether primary phase exists below TP. If the isothermal annealing time is not long enough, both the liquid film and the primary/peritectic interface migrate towards the primary phase until the superheated primary phase has all been dissolved. Then, this migration process towards higher temperature is controlled by temperature gradient zone melting (TGZM). PMID:27075006

  7. Expression of an early gene in the flagellar regulatory hierarchy is sensitive to an interruption in DNA replication.

    PubMed Central

    Dingwall, A; Zhuang, W Y; Quon, K; Shapiro, L

    1992-01-01

    Genes involved in the biogenesis of the flagellum in Caulobacter crescentus are expressed in a temporal order and are controlled by a trans-acting regulatory hierarchy. Strains with mutations in one of these genes, flaS, cannot transcribe flagellar structural genes and divide abnormally. This gene was cloned, and it was found that its transcription is initiated early in the cell cycle. Subclones that restored motility to FlaS mutants also restored normal cell division. Although transcription of flaS was not dependent on any other known gene in the flagellar hierarchy, it was autoregulated and subject to mild negative control by other genes at the same level of the hierarchy. An additional level of control was revealed when it was found that an interruption of DNA replication caused the inhibition of flaS transcription. The flaS transcript initiation site was identified, and an apparently unique promoter sequence was found to be highly conserved among the genes at the same level of the hierarchy. The flagellar genes with this conserved 5' region all initiate transcription early in the cell cycle and are all sensitive to a disruption in DNA replication. Mutations in these genes also cause an aberrant cell division phenotype. Therefore, flagellar genes at or near the top of the hierarchy may be controlled, in part, by a unique transcription factor and may be responsive to the same DNA replication cues that mediate other cell cycle events, such as cell division. Images PMID:1372311

  8. Closed-loop optogenetic control of thalamus as a new tool to interrupt seizures after cortical injury

    PubMed Central

    Paz, Jeanne T.; Davidson, Thomas J.; Frechette, Eric S.; Delord, Bruno; Parada, Isabel; Peng, Kathy; Deisseroth, Karl; Huguenard, John R.

    2013-01-01

    Cerebrocortical injuries, such as stroke, are a major source of disability. Maladaptive consequences can result from post-injury local reorganization of cortical circuits. For example, epilepsy is a common sequela of cortical stroke, yet mechanisms responsible for seizures following cortical injuries remain unknown. In addition to local reorganization, long-range, extra-cortical connections might be critical for seizure maintenance. Here we report in rats the first evidence that the thalamus – a structure remote from but connected to the injured cortex – is required to maintain cortical seizures. Thalamocortical neurons connected to the injured epileptic cortex undergo changes in HCN channel expression and become hyperexcitable. Targeting these neurons with a closed-loop optogenetic strategy demonstrates that reducing their activity in real-time is sufficient to immediately interrupt electrographic and behavioral seizures. This approach is of therapeutic interest for intractable epilepsy, since it spares cortical function between seizures, in contrast to existing treatments such as surgical lesioning or drugs. PMID:23143518

  9. Effects of beam interruption time on tumor control probability in single-fractionated carbon-ion radiotherapy for non-small cell lung cancer.

    PubMed

    Inaniwa, T; Kanematsu, N; Suzuki, M; Hawkins, R B

    2015-05-21

    Carbon-ion radiotherapy treatment plans are designed on the assumption that the beams are delivered instantaneously, irrespective of actual dose-delivery time structure in a treatment session. As the beam lines are fixed in the vertical and horizontal directions at our facility, beam delivery is interrupted in multi-field treatment due to the necessity of patient repositioning within the fields. Single-fractionated treatment for non-small cell lung cancer (NSCLC) is such a case, in which four treatment fields in multiple directions are delivered in one session with patient repositioning during the session. The purpose of this study was to investigate the effects of the period of dose delivery, including interruptions due to patient repositioning, on tumor control probability (TCP) of NSCLC. All clinical doses were weighted by relative biological effectiveness (RBE) evaluated for instantaneous irradiation. The rate equations defined in the microdosimetric kinetic model (MKM) for primary lesions induced in DNA were applied to the single-fractionated treatment of NSCLC. Treatment plans were made for an NSCLC case for various prescribed doses ranging from 25 to 50 Gy (RBE), on the assumption of instantaneous beam delivery. These plans were recalculated by varying the interruption time τ ranging from 0 to 120 min between the second and third fields for continuous irradiations of 3 min per field based on the MKM. The curative doses that would result in a TCP of 90% were deduced for the respective interruption times. The curative dose was 34.5 Gy (RBE) for instantaneous irradiation and 36.6 Gy (RBE), 39.2 Gy (RBE), 41.2 Gy (RBE), 43.3 Gy (RBE) and 44.4 Gy (RBE) for τ = 0 min, 15 min, 30 min, 60 min and 120 min, respectively. The realistic biological effectiveness of therapeutic carbon-ion beam decreased with increasing interruption time. These data suggest that the curative dose can increase by 20% or more compared to the planned dose if

  10. Effects of beam interruption time on tumor control probability in single-fractionated carbon-ion radiotherapy for non-small cell lung cancer

    NASA Astrophysics Data System (ADS)

    Inaniwa, T.; Kanematsu, N.; Suzuki, M.; Hawkins, R. B.

    2015-05-01

    Carbon-ion radiotherapy treatment plans are designed on the assumption that the beams are delivered instantaneously, irrespective of actual dose-delivery time structure in a treatment session. As the beam lines are fixed in the vertical and horizontal directions at our facility, beam delivery is interrupted in multi-field treatment due to the necessity of patient repositioning within the fields. Single-fractionated treatment for non-small cell lung cancer (NSCLC) is such a case, in which four treatment fields in multiple directions are delivered in one session with patient repositioning during the session. The purpose of this study was to investigate the effects of the period of dose delivery, including interruptions due to patient repositioning, on tumor control probability (TCP) of NSCLC. All clinical doses were weighted by relative biological effectiveness (RBE) evaluated for instantaneous irradiation. The rate equations defined in the microdosimetric kinetic model (MKM) for primary lesions induced in DNA were applied to the single-fractionated treatment of NSCLC. Treatment plans were made for an NSCLC case for various prescribed doses ranging from 25 to 50 Gy (RBE), on the assumption of instantaneous beam delivery. These plans were recalculated by varying the interruption time τ ranging from 0 to 120 min between the second and third fields for continuous irradiations of 3 min per field based on the MKM. The curative doses that would result in a TCP of 90% were deduced for the respective interruption times. The curative dose was 34.5 Gy (RBE) for instantaneous irradiation and 36.6 Gy (RBE), 39.2 Gy (RBE), 41.2 Gy (RBE), 43.3 Gy (RBE) and 44.4 Gy (RBE) for τ = 0 min, 15 min, 30 min, 60 min and 120 min, respectively. The realistic biological effectiveness of therapeutic carbon-ion beam decreased with increasing interruption time. These data suggest that the curative dose can increase by 20% or more compared to the planned dose if the

  11. Paradoxical embolism interrupted.

    PubMed

    Desai, Ravi; Ayub, Bilal; Martinez, Matthew W

    2014-02-01

    A 41 year-old African-American male presented with syncope preceded by shortness of breath at outside facility and transferred to us for management of extensive pulmonary embolism with unstable vital signs. Electrocardiogram showed sinus tachycardia with S1Q3T3 pattern. A transthoracic echocardiogram revealed a freely mobile strand like mass in the left atrium. A transoesophageal echocardiogram showed a very large freely mobile thrombus extending from a patent foramen ovale in to the left atrium. He underwent emergent surgery for the extraction of clot followed by thromboembolectomy from both pulmonary arteries. He made a remarkable recovery and was discharged after seven days of hospital stay. PMID:23764146

  12. Automatic circuit interrupter

    NASA Technical Reports Server (NTRS)

    Dwinell, W. S.

    1979-01-01

    In technique, voice circuits connecting crew's cabin to launch station through umbilical connector disconnect automatically unused, or deadened portion of circuits immediately after vehicle is launched, eliminating possibility that unused wiring interferes with voice communications inside vehicle or need for manual cutoff switch and its associated wiring. Technique is applied to other types of electrical actuation circuits, also launch of mapped vehicles, such as balloons, submarines, test sleds, and test chambers-all requiring assistance of ground crew.

  13. An Interrupted Pathway

    ERIC Educational Resources Information Center

    Michell, Dee

    2011-01-01

    It took the author 22 years to get her first undergraduate degree. Not that she studied for all that time, of course, but she first enrolled in 1976 and she didn't graduate with her BA until April 1998. Why did it take so long? Was there something wrong with her? Was there anything anyone else could have done to help her get through university…

  14. Vena cava interruption.

    PubMed

    Fairfax, Lindsay M; Sing, Ronald F

    2011-10-01

    Anticoagulation has been proven to be effective in preventing and treating deep vein thrombosis and pulmonary embolus. However, many critically ill patients are unable to receive anticoagulation or suffer recurrent venous thromboembolism despite adequate treatment. This article examines the use of vena cava filters in the critically ill. Indications for, techniques, and complications of vena cava filter insertion are reviewed. The importance of vena cava filters with the option to be retrieved and bedside insertion in the intensive care unit is emphasized. PMID:22082514

  15. Water Supply Interruptions and Suspected Cholera Incidence: A Time-Series Regression in the Democratic Republic of the Congo

    PubMed Central

    Jeandron, Aurélie; Saidi, Jaime Mufitini; Kapama, Alois; Burhole, Manu; Birembano, Freddy; Vandevelde, Thierry; Gasparrini, Antonio; Armstrong, Ben; Cairncross, Sandy; Ensink, Jeroen H. J.

    2015-01-01

    Background The eastern provinces of the Democratic Republic of the Congo have been identified as endemic areas for cholera transmission, and despite continuous control efforts, they continue to experience regular cholera outbreaks that occasionally spread to the rest of the country. In a region where access to improved water sources is particularly poor, the question of which improvements in water access should be prioritized to address cholera transmission remains unresolved. This study aimed at investigating the temporal association between water supply interruptions and Cholera Treatment Centre (CTC) admissions in a medium-sized town. Methods and Findings Time-series patterns of daily incidence of suspected cholera cases admitted to the Cholera Treatment Centre in Uvira in South Kivu Province between 2009 and 2014 were examined in relation to the daily variations in volume of water supplied by the town water treatment plant. Quasi-poisson regression and distributed lag nonlinear models up to 12 d were used, adjusting for daily precipitation rates, day of the week, and seasonal variations. A total of 5,745 patients over 5 y of age with acute watery diarrhoea symptoms were admitted to the CTC over the study period of 1,946 d. Following a day without tap water supply, the suspected cholera incidence rate increased on average by 155% over the next 12 d, corresponding to a rate ratio of 2.55 (95% CI: 1.54–4.24), compared to the incidence experienced after a day with optimal production (defined as the 95th percentile—4,794 m3). Suspected cholera cases attributable to a suboptimal tap water supply reached 23.2% of total admissions (95% CI 11.4%–33.2%). Although generally reporting less admissions to the CTC, neighbourhoods with a higher consumption of tap water were more affected by water supply interruptions, with a rate ratio of 3.71 (95% CI: 1.91–7.20) and an attributable fraction of cases of 31.4% (95% CI: 17.3%–42.5%). The analysis did not suggest any

  16. Giant Cell Tumor of Bone With Pseudosarcomatous Changes Leading to Premature Denosumab Therapy Interruption: A Case Report With Review of the Literature.

    PubMed

    Sanchez-Pareja, Andrea; Larousserie, Frédérique; Boudabbous, Sana; Beaulieu, Jean-Yves; Mach, Nicolas; Saiji, Essia; Rougemont, Anne-Laure

    2016-06-01

    Denosumab has shown promising results in the management of giant cell tumor of bone, a primary bone tumor with locally aggressive behaviour. We report a case of premature denosumab interruption due to radiological and clinical tumor expansion of a giant cell tumor of the distal ulna. Although denosumab is known to induce tumor regression, with progressive ossification and loss of the characteristic morphology of giant cell tumor of bone, the ulnar tumor specimen showed a moderately to highly cellular proliferation of short spindle-shaped cells, and no osteoclast-like giant cells. There were no abnormal mitotic figures. We considered the surgical specimen as a giant cell tumor of bone with partial regression after prematurely interrupted denosumab treatment. This case illustrates the diagnostic issues of an initially unfavourable evolution raising concern for malignancy, and the difficulties in histological assessment of a partially treated giant cell tumor of bone, that may mimic osteosarcoma. PMID:26842345

  17. Interrupted or continuous slowly absorbable sutures – Design of a multi-centre randomised trial to evaluate abdominal closure techniques INSECT-Trial [ISRCTN24023541

    PubMed Central

    Knaebel, Hanns-Peter; Koch, Moritz; Sauerland, Stefan; Diener, Markus K; Büchler, Markus W; Seiler, Christoph M

    2005-01-01

    Background The closure of the abdomen after median laparotomy is still a matter of debate among surgeons. Further well designed and performed randomised controlled trials determining the optimal method of abdominal fascial closure are needed. Design This is a three armed, multi-centre, intra-operatively randomised, controlled, patient blinded trial. Over 20 surgical departments will enrol 600 patients who are planned for an elective primary abdominal operation. The objective of this study is to compare the frequency of abdominal incisional hernias between two continuous suture techniques with different, slowly absorbable monofilament materials and an interrupted suture using an absorbable braided suture material at one year postoperatively. Conclusion This trial will answer the question whether the continuous abdominal wall closure with a slowly absorbable material with longitudinal elasticity is superior to the continuous suture with a material lacking elasticity and to interrupted sutures with braided thread. PMID:15755324

  18. A series on optimizing satellite systems. I - Restoring interruptions of communications sattelite service: Logistical and cost comparisons of mature and newly operational systems

    NASA Astrophysics Data System (ADS)

    Snow, Marcellus S.

    1989-09-01

    A mathematical model is presented of costs and operational factors involved in provision for service interruptions of both a mature and typically large incumbent satellite system and of a smaller, more recently operational system. The equation expresses the required launch frequency for the new system as a function of the launch spacing of the mature system; the time disparity between the inauguration of the two systems; and the rate of capacity depreciation. In addition, a technique is presented to compare the relative extent to which the discounted costs of the new system exceed those of the mature system in furnishing the same effective capacity in orbit, and thus the same service liability, at a given point in time. It is determined that a mature incumbent communications satellite system, having more capacity in orbit, will on balance have a lower probability of service interruption than a newer, smaller system.

  19. Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis

    PubMed Central

    Xuan, Ziming; Hackman, H Holly; Quinn, Emily; Doe-Simkins, Maya; Sorensen-Alawad, Amy; Ruiz, Sarah; Ozonoff, Al

    2013-01-01

    Objective To evaluate the impact of state supported overdose education and nasal naloxone distribution (OEND) programs on rates of opioid related death from overdose and acute care utilization in Massachusetts. Design Interrupted time series analysis of opioid related overdose death and acute care utilization rates from 2002 to 2009 comparing community-year strata with high and low rates of OEND implementation to those with no implementation. Setting 19 Massachusetts communities (geographically distinct cities and towns) with at least five fatal opioid overdoses in each of the years 2004 to 2006. Participants OEND was implemented among opioid users at risk for overdose, social service agency staff, family, and friends of opioid users. Intervention OEND programs equipped people at risk for overdose and bystanders with nasal naloxone rescue kits and trained them how to prevent, recognize, and respond to an overdose by engaging emergency medical services, providing rescue breathing, and delivering naloxone. Main outcome measures Adjusted rate ratios for annual deaths related to opioid overdose and utilization of acute care hospitals. Results Among these communities, OEND programs trained 2912 potential bystanders who reported 327 rescues. Both community-year strata with 1-100 enrollments per 100 000 population (adjusted rate ratio 0.73, 95% confidence interval 0.57 to 0.91) and community-year strata with greater than 100 enrollments per 100 000 population (0.54, 0.39 to 0.76) had significantly reduced adjusted rate ratios compared with communities with no implementation. Differences in rates of acute care hospital utilization were not significant. Conclusions Opioid overdose death rates were reduced in communities where OEND was implemented. This study provides observational evidence that by training potential bystanders to prevent, recognize, and respond to opioid overdoses, OEND is an effective intervention. PMID:23372174

  20. Insights on Physics of closed drift plasma thrusters by using externally driven and very fast current interruptions

    NASA Astrophysics Data System (ADS)

    Bouchoule, André

    2002-10-01

    Closed electron drift plasma thrusters, also known as Hall Thrusters or SPT (Stationary Plasma Thrusters) are magnetized discharges where the ion acceleration is provided in the plasma itself by the magnetic barrier restricting electron transport. After their developments and their demonstrations on satellites for orbit control these thrusters appear as very attractive ones in the space technology market. Simultaneously, significant research programs are developed in order to improve the knowledge on the complex physics involved in such devices and to improve simultaneously 2D or 3D simulation codes. Such a program involving academic research teams , agencies and industry is developed in France, in the frame of a coordinated program. GDR N° . The experimental research was achieved on diagnostic equipped thrusters, similar to industrial ones. These thrusters are operated in the national research facility PIVOINE , installed in Orléans. The discharge of Hall thrusters is well known as sensitive to fluctuations or oscillations in the few tens kHz range and the physical phenomena connected to these regimes have been widely investigated. Externally driven current interruptions, with very fast ON-OFF transitions (0.15 µs), have been shown as a convenient way for obtaining new data on thrusters physics, in connection with time resolved diagnostics like OES, LIF, electron Hall current probe and RFA. Experimental results evidence some details on excitation / ionization (single and multiply charged Xe ions) phenomena and lead to new inputs on electron transport phenomena in the magnetized discharge channel. New experimental insights on microinstabilities will be also be discussed in relation with simulations developed by using PIC codes.