The murine mammary carcinoma, TA3/St, grows aggressively in ascites and rapidly invades the peritoneal wall of syngenetic mice. The hyaluronan content of ascites increases markedly during TA3/St cell proliferation therein and hyaluronan is enriched at sit...

... In the present study, we have used a murine mammary carcinoma line (TA3/St) which grows in ascites form and metastasizes through the ...

Effective treatment of transplanted murine mammary tumors with an oncolytic virus and cyclophosphamide is reported. The oncolytic virus was cultured initially from a murine ascites tumor that had undergone spontaneous regression. This virus used alone causes rapid lysis of ascites tumors, but successful treatment ...

Ehrlich ascites carcinoma is a spontaneous murine mammary adenocarcinoma adapted to ascites form and carried in outbred mice by serial intraperitoneal (i/p) passages. The previous work from our laboratory showed that honey having higher phenolic content was potent in inhibiting colon cancer cell proliferation. In this work, we extended ...

Following large doses of x radiation, death of a murine ascites lymphoma cell occurred by a rapid intermitotic mechanism. The desoxyribonucleic acid (DNA) of these cells was labeled with tritiated thymidine, the cells killed by x- irradiation, and injected intravenously into recipient mice with growing ascites tumors. Tritium ...

Virus stocks for 3 arboviruses, namely California, Turlock and Sicilian Sandfly have been prepared, titrated and neutralized by homologous antisera. Mice ascertained free of antibodies for 7 murine viruses have been used in pilot studies of (a) ascites fo...

The re-formed agent pool of Turlock virus deemed type-specific from the results of the tests and found free of adventitious microorganisms and several murine viruses was used to prepare 15 subpools (total 6,700 ml) of immune ascitic fluid and 6 subpools (...

of the human placental lactogen precursor to its native form in ascites cell-free extracts. Eur. J. Biochem and unprocessed nascent immunoglobul in light chains on membrane-bound ribosomes of murine myeloma . J. Cell Biol

A murine ascites tumour was treated with intraperitoneal haematoporphyrin derivative (HPD) and laser light (10mW, 514nm, Argon laser). HPD was given intraperitoneally 2 hours before 16 minute laser treatment. Uptake studies 2 hours after HPD injection showed 5-12 fold greater concentration of HPD in tumour cells than in 4 different normal tissues. A total ...

THE modification of the effect of radiation on a murine ascitic tumour irradiated in vivo by pharmacological agents has been previously reported1-3. In those investigations the effect of radiation on the reproductive capacity of ascitic tumour cells was modified by direct injection of the pharmacological agent into the peritoneal ...

The production of ascitic fluid and splenomegaly on intraperitoneal injection in weanlings was used as a test for microsporidia after introduction by other routes and in other loci. Oral and cerebral administration was followed only by enlarged spleens which reproduced the ascitic response on passage. Microsporidia were demonstrable by phase microscopy in ...

Two murine experimental tumor models of different aggressiveness (murine Ehrlich ascitic carcinoma and MH-22A hepatoma) were used to investigate the radiosensitization by porphyrins. Data obtained clearly indicate that hematoporphyrin dimethyl ether, photofrin and hematoporphyrin derivative exert some radiosensitizing properties which ...

A20 or tumor necrosis factor�induced protein 3 is a negative regulator of nuclear factor ?B signaling. A20 has been shown previously to attenuate cardiac hypertrophy in vitro and postmyocardial infarction remodeling in vivo. In the present study, we tested the hypothesis that overexpression of A20 in the ...

We have established a novel ascites tumour model (MDA435/LCC6) from the oestrogen receptor-negative, invasive and metastatic MDA-MB-435 human breast cancer cell line. MDA435/LCC6 cells grow as both malignant ascites and solid tumours in vivo in nude mice and nude rats, with a tumour incidence of approximately 100%. Untreated mice develop ...

controls indicated that the methods were specific. Spatial structures of snake venom toxins by NMR~rich Cardiotoxins from snake venoms produce a variety of toxic effects, e.g. depolarization of membranes, hemolysis

Comparative measurements have been made of the transplantation and electrical surface charge properties of the near-diploid TA3-Ha ascites tumor and a new hypotetraploid ascites subline designated TA3-L. The negative surface charge density and the density of electrophoretically detectable sialic acid residues were determined to be twice as great for TA3-L ...

A monoclonal antibody has been prepared against rat angiotensin-converting enzyme (ACE). By selection for antibody binding to endothelial cells of bovine rather than rat origin we have obtained a reagent that has broad cross-species binding properties and that can at the same time serve as a useful marker for the surface of endothelial cells. The IgM-producing clone that we have established, ? ...

Vanadium, as ammonium monovanadate, has been found to stimulate tumour cell proliferation in mice bearing a transplantable ascitic lymphoma. Markers including microsomal cytochrome P-450, UDP-glucuronyltransferase and cytosolic glutathione-S-transferase showed substantial alterations in a dose-responsive manner with vanadium administration when compared to the controls. ...

Six new platinum (II)-sulfonamide complexes were examined for their in vitro cytostatic properties as well as in vivo antitumour effect against three experimental murine tumours. The possible antitrypanosomic in vivo activity against T. brucei, T. congolense and T. cruzi infections was also evaluated. The synthesis and chemical characterization of new complexes is reported. ...

Genetic Markers for Ascites Resistance and Susceptibility in Chickens Ascites and right ventricular enlargement arising from pulmonary hypertension. Ascites occurs more frequently as genetic markers for selection of birds that are naturally resistant to ascites. These markers may

The role of abrin, a toxic lectin isolated from seeds of Abrus precatorius Linn in inducing apoptosis in murine Dalton's Lymphoma Ascites (DLA) cells was evaluated. Abrin when incubated at the concentration of 10 ng per million DLA cells could bring about cell death as typical morphological changes with apoptosis. However, necrotic cell death dominated ...

An initial panel of 34 hybridomas, each secreting antibodies reactive with an infective theront stage of an Ichthyophthirius multifiliis isolate, was produced. Three of these cell lines, each producing immunoglobulin M class antibodies, were cloned by limiting dilution and were expanded as ascites-producing tumors in syngeneic mice. Three monoclonal antibodies (MAB) reacted ...

Antigen was synthesized with L-SCP, a sea cucumber polysaccharide isolated from Pearsonothuria graeffei (Semper) and bovine serum albumin (BSA) as a carrier protein. Spleen cells with high titer antibody producing ability were removed and fused with myeloma cells of SP2/0-Ag14 origin. Three stable murine monoclonal antibodies (MAb ascites) producing cell ...