Was there any redox disequilibrium at the potential sites? " Would potential chemolithotrophs have been able to take advantage of redox reactions? ...

Back to Index   � Home   � Goals   � Members   � Documents   � Links Cancer Redox Biology Faculty Goals The goals of the Cancer Redox Biology Faculty are to: 1) Investigate how the signal transduction and expression of genes are altered by redox

The redox status of a system may be analyzed in terms of the redox potential (redox intensity component) and the size of the pool of electrons able to be transferred (redox capacity component). In single chemical systems, both terms are thermodynamically related by means of the Nernst equation, the classical ...

AbstractBy virtue of its unique electrochemical properties, iron makes an ideal redox active cofactor for many biologic processes. In addition to its important role in respiration, central metabolism, nitrogen fixation, and photosynthesis, iron also is used as a sensor of cellular redox status. Iron-based sensors incorporate Fe-S ...

A redox titrator for the preparation of small volumes of highly concentrated biological samples of X-ray synchrotron studies provides for the redox equilibration at temperatures of 40 to -30/sup 0/C. Anaerobic transfer directly to the X-ray sample chamber and mixing of an additional reagent just prior to freeze-trapping of the ...

Greatest conversion of arsenic to 'biological' species was found at the surface in the Subtropical Convergence Zone (2.5%) and decreased heading southward ...

... for biological fractionation during redox cycling of Fe by bacteria that highlights the unique isotopic effects in biologic versus inorganic systems. ...

Combining in situ voltammetry and molecular biology to characterize geomicrobial synergy within diverse aquatic redox gradients. Brian T. Glazer ...

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 10/4/07 Location: 10/2S235 conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Dr. Wink announced that the Redox Biology

Redox states in all biological systems including plants are thought to play vital roles in maintaining and/or regulating cellular processes and metabolisms in response to extreme conditions, such as oxidative stresses, nutritional perturbation, and metabolic disorders. There is a growing body of ev...

Dr. Moody discussed the Redox Biology course which will begin on Sept. 14 at 4 p.m. 50 Registrants have been accepted but another 60 remain on the waiting list.

The present invention provides methods and compositions for detecting the presence of biologically-important analytes by using redox liposome biosensors. In particular, the present invention provides liposome/sol-gel electrodes suitable for the detection of a wide variety of organic molecules, including but not limited to bacterial toxins.

Back to Index   � Home   � Goals   � Members   � Documents   � Links Cancer Redox Biology Faculty Documents �   workshop 07 Thomas powerpoint �   Chance Powerpoint Redox states of small animal cancer: Modulation of heterogeneity �   Morrow Powerpoint Quantification

Redox states in all biological systems including plants are thought to play vital roles in maintaining and/or regulating cellular processes and metabolisms in response to extreme conditions, such as oxidative stresses, nutritional perturbation, and metabolic disorders. There is a growing body of evi...

In common with other aerobic organisms, plants are exposed to reactive oxygen species resulting in formation of post-translational modifications related to protein oxidoreduction (redox PTMs) that may inflict oxidative protein damage. Accumulating evidence also underscores the importance of redox PTMs in regulating enzymatic activities and controlling ...

Sulfur and selenium occur in proteins as constituents of the amino acids cysteine, methionine, selenocysteine, and selenomethionine. Recent research underscores that these amino acids are truly exceptional. Their redox activity under physiological conditions allows an amazing variety of posttranslational protein modifications, metal free redox pathways, ...

Abstract The intestinal tract, known for its capability for self-renew, represents the first barrier of defense between the organism and its luminal environment. The thiol/disulfide redox systems comprising the glutathione/glutathione disulfide (GSH/GSSG), cysteine/cystine (Cys/CySS) and reduced and oxidized thioredoxin (Trx/TrxSS) redox couples play ...

Analytica Chimica Acta, 409, 215-226. Featherstone, A.M. (1999) Arsenic speciation in estuarine and oceanic waters by hydride generation - atomic ...

Featherstone, A.M. (1999) Arsenic speciation in estuarine and oceanic waters by hydride generation - atomic fluorescence spectroscopy PhD Thesis, ...

... that underlie stem cell function by ... Descriptors : *STEM CELLS, *CANCER, *GENES, TARGETS ... OXYGEN, BONDING, CELLS(BIOLOGY), SULFIDES ...

... Protein oxidizing agents, chloramine-T the hydroxyl radicals at one site ... biological damaye: the essential role of redox-active transition Pellmar T ...

Measurements of heart rate, blood oxygenation, redox state of cytochrome oxidase and .... Diesease in Adelie and Emperor Penguins [K034_2001_2005_NZ_11] ...

Significance. Plant biologists and microbiologists have long discussed and debated the physiological roles of so-called "redox-active metabolites". These are natural products with unusually high redox activity that are not directly required for active growth. Generally, the biological roles of these compounds have been ascribed to ...

Transcription of the sodA gene of Escherichia coli, which encodes manganese superoxide dismutase, is governed by six global regulators: the product of the soxRS locus (superoxide response) and mutated alleles of the soxQ locus (such as cfxB) act as activators; the products of the fur (ferric uptake regulation), arcA (aerobic regulation control), and fnr (fumarate nitrate reductase) genes and the ...

Thiol-dependent redox systems are involved in regulation of diverse biological processes, such as response to stress, signal transduction, and protein folding. The thiol-based redox control is provided by mechanistically similar, but structurally distinct families of enzymes known as thiol oxidoreductases. Many such enzymes have been ...

Sulphur metabolism in plants provides a wealth of natural products, including several chemically unusual substances, such as thiosulphinates, polysulphides and isothiocyanates. Many of these reactive sulphur species (RSS) exhibit a distinct redox behaviour in vitro, which translates into a rather interesting biological activity in vivo, such as antibiotic, ...

There are little literatures about the accelerating effect of redox mediators on the denitrification processes. In this paper, a novel non-dissolved redox mediator catalyzing biological denitrification (RMBDN) technology was first explored, and the accelerating effect of redox mediator on the denitrification ...

A method is developed to express the flux of an electron transfer reaction as a function of the conjugate force, the redox potential difference, throughout the nonlinear region. The flux can be expressed by a product of the hyperbolic sine of the force, a factor ("redox-poising parameter") determined by the redox potentials of ...

Here, we report the reversible interconversion between NADH and NAD(+) at a low overpotential, which is in part mediated by ubiquinone embedded in a biomimetic membrane to mimic the initial stages of respiration. This system can be used as a platform to examine biologically relevant electroactive molecules embedded in a natural membrane environment and provide new insights ...

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 6/05//08 Location: 10/2S235 conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Dr. C. Harris presented research on cytokines

Abstract Aims: The study of the intracellular oxido-reductive (redox) state is of extreme relevance to the dopamine (DA) neurons of the substantia nigra pars compacta. These cells possess a distinct physiology intrinsically associated with elevated reactive oxygen species production, and they selectively degenerate in Parkinson's disease under oxidative stress conditions. To ...

This project focused on the design and integration of biological sensors with nanoelectronic circuitry, using a diverse array of live redox proteins and biomolecules and based on the development of innovative linkers between the biological systems and the...

CCR Home��|�� About CCR��|�� CCR Intranet��| ��Search�� Intramural Research Faculty Chairs Discipline Based Name Faculty Wink, David Cancer Redox Biology Faculty Keefer, Larry Chemistry and Structural Biology Faculty Singer, Alfred Immunology Faculty Roberts,

Minerals can be produced and deposited either by abiotic or biologic means. Regardless of their origin, mineral crystals reflect the environment conditions (e.g., temperature, pressure, chemical composition, and redox potential) present during crystal for...

Research conducted during the last two decades has provided evidence for the existence of an extensive intracellular redox signalling, control and feedback network based on different cysteine-containing proteins and enzymes. Together, these proteins enable the living cell to sense and respond towards external and internal redox changes in a measured, ...

Oxidation reactions in coffee involve redox-sensitive polyphenols and appear to control the fragmentation of coffee storage proteins both in solution and during roasting. Coffee-specific nitrogenous flavor precursors may derive from this process. Accordingly, data converge to suggest that the redox status of the green bean before roasting might control the ...

The investigations described show that the formation of elemental sulfur from the biological oxidation of sulfide can be optimized by controlling the redox state of the solution. The nonsoluble sulfur can be removed by gravity sedimentation and re-used as a raw material, i.e., in bioleaching processes. It was shown that, by supplying an almost ...

Significance: Redox-based signaling governs a number of important pathways in tissue homeostasis. Consequently, deregulation of redox-controlled processes has been linked to a number of human diseases. Among the biological processes regulated by redox signaling, apoptosis or programmed cell death is a highly ...

Free-radical intermediates, particularly the activated oxygen species OH, O/sup -//sub 2/, and /sup 1/O/sub 2/, are implicated in many types of radiation damage to biological systems. In addition, these same species may be formed, either directly or indirectly through biochemical redox reactions, in both essential and aberrant metabolic processes. Cell ...

Access to the article is free, however registration and sign-in are required. Mitchell's chemiosmotic theory of energy coupling may have won him the Nobel Prize, but scientists are still pondering how the transmembrane proton gradient he postulated is generated. In their Perspective, Richardson and Sawers discuss the newly resolved structure of a bacterial respiratory enzyme (Jormakka et al.), ...

A variety of redox mediating agents employing bipyridinium reagents and such reagents in conjunction with dispersed noble metals, such as platinium, are disclosed as coatings for substrates and electrodes. The agents may be charged by an applied voltage or by photoelectric effects or may be equilibrated with hydrogen. The agents are useful in reducing ...

regulation Sulfenic acid a b s t r a c t Model reactions offer a chemical mechanism by which formation a sulfenic acid residue (reaction i, Scheme 1A) that can, over time, be returned to the native thiol by reactions with biological thiols (reaction ii, Scheme 1A).4�8 Protein sulfenic acid residues also have

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 9/28/05 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: Drs. D. Wink (chair), S. Ambs,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 9/13/06 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: Drs. D. Wink (chair), S. Ambs,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 6/8/04 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: Dr. D. Wink (Chair), S. Ambs,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 6/14/05 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: Drs. D. Wink (chair), S. Ambs,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 5/11/04 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: Dr. D. Wink (Chair), S. Ambs,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 5/01//08 Location: 10/2S235 conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Dr. S. Perwez Hussain presented research

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 4/25/07 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: Drs. D. Wink (chair), S. Ambs,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 4/13/04 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: David Wink, Stephan Ambs, Mike

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 2/08//08 Location: 10/2S235 conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Dr. Stefan Ambs presented research on the

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 12/8/04 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: Drs. D. Wink (chair), S. Ambs,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 12/06//07 Location: 10/2S235 conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Dr. Kevin Gardner presented research on

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 11/15/06 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: Drs. D. Wink (chair), S. Ambs,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 11/1//07 Location: 10/2S235 conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Dr. Dave Roberts presented research on

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 10/12/04 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: David Wink, Mike Espey, David

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 1/31/06 Location: 10/B2.5B conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: Drs. D. Wink (chair), S. Ambs,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 1/13/05 Location: NCI retreat Head Organizer: David Wink Summary Prepared By: Terry Moody Attendance: Drs. D. Wink (chair), S. Ambs, M. Espey,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 1/7/2010 Location: Bethesda North Marriott Head Organizer: David Wink Summary Prepared By: Terry Moody Drs. David Wink, Stefan Ambs, Perwez Hussain,

Name/Title of Meeting: Cancer Redox Biology Steering Committee Meeting Date of Meeting: 1/03//08 Location: 10/2S235 conference room Head Organizer: David Wink Summary Prepared By: Terry Moody Dr. Terry Moody presented research on S-NSAIDs

This review article with 105 references discusses the most recent publications that deal with the discovery of new redox proteins of the sulfate-reducing bacteria belonging to the genera Desulfotomaculum and Desulfovibrio and proposes explanations for their physical and biological functions. The redox proteins studied as part of the ...

Many chemically and biologically important trace element, heavy metal, and organic contaminant reactions in soils are constrained by pH and redox conditions and changes in these conditions can significantly affect reaction rates. Although closed-system, batch methods have been used for many years to...

To enhance communication among cellular biologists, molecular biologists, clinical oncologists and epidemiologists who are interested in the molecular mechanisms by which redox stress alters carcinogenesis, cancer cellular proliferation, tumor angiogenesis, tumor imaging and treatment of cancer patients. We facilitate interdisciplinary collaborative research and enhance ...

Detailed thermodynamic and structural data measured in soluble monomeric multiheme cytochromes c provided the basis to investigate the functional significance of interactions between redox co-factors. The steep decay of intramolecular interactions with distance means that close proximity of the redox centers is necessary to modulate the intrinsic reduction ...

Abstract Shear stress plays a critical role in the regulation of vascular biology and diseases, such as atherosclerosis, via modulation of signal transduction and redox balance. Atherosclerosis preferentially occurs in a site-specific manner linked to disturbed flow. In this Forum on Vascular Shear Stress, emerging role of ...

� Background Reactive oxygen species are produced in a highly localized and specific pattern in biological stress responses. The present review examines the redox regulatory aspects of a number of molecular stress response mechanisms in both prokaryotes and eukaryotes.� Scope The present review provides examples representing both the cytoplasmic stress ...

Using DNA-modified electrodes, we show DNA-mediated signaling by XPD, a helicase that contains a [4Fe-4S] cluster and is critical for nucleotide excision repair and transcription. The DNA-mediated redox signal resembles that of base excision repair proteins, with a DNA-bound redox potential of ?80 mV versus NHE. Significantly, this signal increases with ...

BackgroundAlthough the mechanisms of airborne particulate matter (PM) related health effects remain incompletely understood, one emerging hypothesis is that these adverse effects derive from oxidative stress, initiated by the formation of reactive oxygen species (ROS) within affected cells. Typically, ROS are formed in cells through the reduction of oxygen by biological ...

A survey of the literature indicates that several chemicals whose reduced metabolites are capable of undergoing redox cycling in biological systems also possess significant teratogenic properties when tested in vivo. The authors have initiated investigations to determine whether the embryotoxic effects of such chemicals could result from their ...

The method of determination of Redox potentials of radicals, using the pulse radiolysis technique, is outlined. The method is based on the determination of equilibria constants of electron transfer reactions between the radicals and appropriate acceptors. The limitations of this technique are discussed. The redox potentials of several ...

During the last two decades, extensive research has explored the catalytic effects of different organic molecules with redox mediating properties on the anaerobic (bio)transformation of a wide variety of organic and inorganic compounds. The accumulated evidence points at a major role of electron shuttles in the redox conversion of several distinct ...

Dr. Arne Holmgren (Ph.D., 1968) is recognized here as a redox pioneer, because he has published at least one article on redox biology that has been cited over 1000 times and has published at least 10 articles, each cited over 100 times. He is widely known for his seminal discoveries and in-depth studies of thioredoxins, thioredoxin ...