Unlike the situation of resistance (R) gene mediated cell death, the biochemical mechanism for the fungal toxin ToxA-caused cell death is not well-defined. Resistance associated with the gene-for-gene interaction is usually manifested in a form of programmed cell death ...
Technology Transfer Automated Retrieval System (TEKTRAN)
BackgroundAutophagy is an evolutionarily conserved protein degradation pathway. A defect in autophagy may contribute to tumorigenesis. Autophagy inducers could have a potential function in tumor prevention and treatment.Methodology/Principal FindingsOur results showed that Rhabdastrellic acid-A, an isomalabaricane triterpenoid isolated from the sponge Rhabdastrella globostellata, inhibited ...
PubMed Central
- and anti-apoptotic Bcl-2 family proteins interact in a complex network, and set the threshold for apoptosis all the cells had undergone apoptosis. In contrast, significant decreases in Mcl-1 protein levels proteins. In SJSA cells, 24h treatment with Nutlin-3a induced low levels of Bax activation and apoptosis
E-print Network
Thaxtomin A (TXT) is a phytotoxin produced by all plant-pathogenic Streptomyces scabies involved in the potato scab disease. Their pathogenicity was previously correlated with the production of TXT. Calcium is known to be an essential second messenger associated with pathogen-induced plant responses and cell death. We have effectively shown that in ...
Amyloid ? peptide (A?) induced toxicity is a well-established pathway of neuronal cell death which might play a role in Alzheimer's disease. In this regard, the toxic effect of A? on a cultured A?-sensitive neuronal cell line was used as a primary screening tool for potential anti-Alzheimer's ...
PubMed
Brain accumulation of the amyloid-? peptide (A?) and oxidative stress underlie neuronal dysfunction and memory loss in Alzheimer's disease (AD). Hexokinase (HK), a key glycolytic enzyme, plays important pro-survival roles, reducing mitochondrial reactive oxygen species (ROS) generation and preventing apoptosis in neurons and other cell types. Brain isozyme HKI is mainly ...
Helicobacter pylori is a Gram-negative bacterium that colonizes the human stomach and contributes to the development of peptic ulcer disease and gastric cancer. The secreted pore-forming toxin VacA is one of the major virulence factors of H. pylori. In the current study, we show that AZ-521 human gastric epithelial cells are highly susceptible to VacA-induced ...
The accumulation of misfolded proteins in the lumen of the endoplasmic reticulum (ER) results in cellular stress that initiates a specialized response designated as the unfolded protein response. ER stress has been implicated in a variety of common diseases, such as diabetes, ischemia and neurodegenerative disorders. Withaferin A, a major chemical constituent of Withania somnifera, has been ...
BackgroundIn the facultative human pathogen Mycoplasma hominis, which belongs to the cell wall-less Mollicutes, the surface-localised substrate-binding domain OppA of the oligopeptide permease was characterised as the main ecto-ATPase.ResultsWith the idea that extra-cellular ATP could only be provided by the infected host cells we analysed the ATP release ...
Amyloid ? (A?) peptide plays a central role in neuronal apoptosis, promoting oxidative stress, lipid peroxidation, caspase pathway activation and neuronal loss. Our previous study has shown that bone marrow-derived mesenchymal stem cells (BM-MSCs) reduce A? deposition when transplanted into acutely-induced Alzheimer's disease (AD) mice brain. However, the impact of reduced A? ...
Haplophytin-A (10-methoxy-2,2-dimethyl-2,6-dihydro-pyrano[3,2-c]quinolin-5-one), a novel quinoline alkaloid, was isolated from the Haplophyllum acutifolium. In this study, we investigated the effect of haplophytin-A on the apoptotic activity and the molecular mechanism of action in human promyelocytic leukemia HL-60 cells. Treatment with haplophytin-A (50?M) induced classical ...
Treatment of various types of cells with diazoxide has been shown to precondition cells to subsequent injuries and inhibit cell death. In this study, the protective effects of diazoxide against pharmacological inhibition of the respiratory chain were studied using osteoblastic MC3T3-E1 cells ...
The present study was designed to investigate the potential neuroprotective effect of ?-conotoxin (?-CTX) in a cell-based model of Alzheimer's disease (AD) using cultured PC12 cells incubated with ?-amyloid (A?). Immunohistochemical staining, Western blot, MTT and TdT-mediated dUTP-biotin nick end labeling (TUNEL) analysis were employed to assess the ...
BACKGROUND & AIMS: Helicobacter pylori infection is a risk factor for gastric cancer. Ammonia/ammonium (A/A) is a cytotoxin generated by H pylori that kills gastric epithelial cells. We investigated whether A/A cytotoxicity occurs by activating N-methyl D-aspartate (NMDA) channels, which results in Ca2(+) permeation and epithelial cell ...
