Professor Daniel Geschwind discusses the importance of his group's discovery of an autism locus on chromosome 17.

). The importance of the root locus method for control system theory lies in the fact that the location the static gain (the essence of the root locus method), one has to design a dynamic compensator (controllerEssence of the Root Locus Technique In this chapter we study a method for finding locations

The aim of this work was to investigate the association of health locus of control with depression among adolescents in Alexandria, Egypt. The tools used were a self-report questionnaire covering demographic data and some factors associated with depression, the Multidimensional Health Locus of Control scale and the Child Depression Inventory. Adolescents ...

Nearly all diseases mapped to date follow clear Mendelian, single-locus segregation patterns. In contrast, many common familial diseases such as diabetes, psoriasis, several forms of cancer, and schizophrenia are familial and appear to have a genetic component but do not exhibit simple Mendelian transmission. More complex models are required to explain the genetics of these ...

... cancer susceptibility alleles, with such genes being estimated ... this finding multiple other HPC loci have been ... our finding of the HPCX locus at Xq27 ...

... cancer susceptibility alleles, with such genes being estimated to ... this finding three other HPC loci have been ... our finding of the HPGX locus at Xq27 ...

The aim of this study is to investigate the role of the prospective teachers' locus of control in goal orientations and of both orientations in academic achievement. The participants were 270 undergraduate students studying in different majors at the Faculty of Education in Pamukkale University. Goal Orientations and Locus of Control Scales were used to ...

This report reviews the work performed on five tasks: 1. Write a computer program for the root locus method. 2. Write a computer program for the time-lag root locus method. 3. Examine systems with distributed time-lag in order to find a stability criterio...

The paper considers the use of well known root-locus techniques for sequentially finding the weighting matrices and the linear quadratic state regulators of multivariable control systems in the frequency domain. The proposed sequential design method enabl...

The research attempted to replicate and extend a number of findings relating work variables to an individual's perceived locus of control. Over 900 employees, including 169 managers, of a large metropolitan area utility participated in the study. (Modifie...

:371�382. Aston-Jones G, Hirata H, Akaoka H (1997) Local opiate withdrawal in locus coeruleus in vivo. Brain Res of effect of opiate antagonists. The present findings pro- vide evidence that endogenous opioids regulate LC: corticotropin-releasing hormone; opiate; locus ceruleus; norepinephrine; hypotension; naloxone A role

We present an analysis on the locus formed by the set of maxima of the trajectories of a projectile launched in a medium with linear drag. Such a place, the locus of apexes, is written in terms of the Lambert "W" function in polar coordinates, confirming the special role played by this function in the problem. To characterize the ...

The R locus in maize controls the tissue specificity of anthocyanin formation. Recombination between two different R-locus alleles with unique pigmentation domains has resulted in the generation of a nonparental allelic type that displays a third kind of tissue specificity. These novel changes in tissue specificity occurred in very low frequency (1 x ...

Background:Adequate self-care in diabetes improves quality of life and decreases the number of inpatient cases. The health locus of control theory is used to assess adherence to diabetes regimen in some studies in developed countries. The primary purpose of this cross-sectional study is to determine the status of diabetes locus of control in a sample of ...

Sep 9, 2009 ... A window will open that shows the names of many different statistical analysis functions. Slide down to find "Regression". ...

The dynamical behavior of the three-way linkage disequilibrium function is investigated within deterministic, three locus hitchhiking systems consisting of two neutral loci and one selected locus. The analysis is based on the case in which at least one of the neutral loci is initially in linkage equilibrium with the selected locus. It ...

OBJECTIVE: To investigate how training older adults to find medical information using the Internet affects their locus of control. METHODS: Quantitative methods were utilized. Specifically, the Multidimensional Health Locus of Control survey was distributed at the onset of each seminar and again at the conclusion. RESULTS: Paired ...

Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli O157:H7 are intestinal pathogens that profoundly damage the microvilli and subapical cytoskeleton of epithelial cells. Here we report finding in EPEC a 35-kbp locus containing several regions implicated in formation of these lesions. DNA probes throughout this locus ...

workpieces without visual or other feedback. Here we find the locus of centers of rotation of a workpiece is stationary on a work surface, and a fence or gripper under control of a robot pushes it.) And similar is in general unknown. But we are able to find the locus of centers of rotation (that is, the set of all

or other feedback. Here we find the locus of centers of rotation of a workpiece for all possible pressure on a work surface, and a fence or gripper under control of a robot pushes it.) And similar interactions is in general unknown. But we are able to find the locus of centers of rotation (that is, the set of all

The program described in this report was developed to find the poles and zeros of a closed loop feedback system. In order to do this, it is necessary to find the roots of the characteristic equation of the system. The program alters the characteristic equ...

BackgroundSubjects with a ring scotoma can use two retinal loci, a foveal and a peripheral, for reading. Our aim was to investigate the relative use of both retinal loci as a function of the spared foveal area size and the spatial resolution at both retinal loci.FindingsTwo patients with Stargardt's disease and ring scotomas read through a scanning laser ophthalmoscope a ...

Investigations are needed to illuminate how teachers at different degrees of burnout perceive stressful situations (either internally or externally) and how they perceive the control of pupil behavior. This paper summarizes a study exploring whether there is a direct relationship between: (1) locus of control and teacher burnout; (2) pupil control ideology and teacher burnout; ...

The self-incompatibility (SI) response in Papaver rhoeas depends upon the cognate interaction between a pollen-expressed receptor and a stigmatically expressed ligand. The genes encoding these components are situated within the S-locus. In order for SI to be maintained, the genes encoded by the S-locus must be co-inherited with no recombination between ...

BackgroundPurely epistatic multi-locus interactions cannot generally be detected via single-locus analysis in case-control studies of complex diseases. Recently, many two-locus and multi-locus analysis techniques have been shown to be promising for the epistasis detection. However, exhaustive ...

Compaction and looping of the ~2.5-Mb Igh locus during V(D)J rearrangement is essential to allow all V(H) genes to be brought in proximity with D(H)-J(H) segments to create a diverse antibody repertoire, but the proteins directly responsible for this are unknown. Because CCCTC-binding factor (CTCF) has been demonstrated to be involved in long-range chromosomal interactions, we ...

A new, environmentally benign whey protein fractionation process was developed using supercritical CO2 (SCO2) as an acid aggregating agent to separate a-lactalbumin (a-LA) aggregates from soluble beta-lactoglobulin (beta-LG) protein in concentrated whey protein isolate (WPI) solutions. The process e...

Results are reported from a study of the nature of x-rayinduced backmutation at the melezitose locus in Saccharomyces. The findings support the view that backmutation to wild type is a single event and involves an all or none reaction. The possible nature of the radiation-induced events leading to sequential degradation of the gene and its abrupt ...

Comparative studies in mice indicated that fast neutrons at low intensity are about 5 to 6 times as effective as x rays at high intensity for the induction of both dominant lethals in spermatozoa and specific locus mutations in spermatogonia. Implications of the findings in studies of mammalian radiation genetics are discussed. (C.H.)

Allelic differences at the Ah locus are shown to exist in the mouse brain. This finding probably explains inbred mouse strain differences in polycyclic hydrocarbon tumorigenesis of the brain described more than 35 years ago and may be important in understanding the etiology of genetic differences in certain human intracranial neoplasms.

This project was designed to investigate the effect of the use of cause-and-effect activities in the science curriculum on the locus of control of the learner. The purpose of this research is to find the effect of the activities on the learner's locus of control and attitude toward science at grades 7 through 10. A multivariate ...

Given the remarkable similarities between the genetics of tau diseases and the genetics of alpha-synuclein diseases, and given the fact that we have recently found a triplication of the alpha-synuclein locus in a family in which we had shown linkage to the alpha-synuclein locus, we determined to test whether some of the several families with autosomal ...

New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. ...

Linkage of tuberous sclerosis complex (TSC), an autosomal dominant disorder, to markers on chromosome 9 was reported first in 1987. This assignment was confirmed by an international collaborative study that suggested more than one locus may be responsible for the phenotype. The authors studied 14 multigenerational TSC families (13 previously unreported) with markers for nine ...

Cellular senescence is the biological consequence of aging. However, the same mechanisms that provoke senescence during aging have been proven to act in tumor suppression and thus to occur in premalignant cells. All the diverse aspects of the senescent phenotype, as are observed for many other cell fates, arise from alterations of the chromatin architecture. Relatively little is known overall ...

We describe an autosomal-dominant locus for Restless Legs Syndrome (RLS) in a French-Canadian (FC) pedigree. Genome-wide microsatellite scan and linkage analysis were used in this study. The locus maps to chromosome 16p12.1 and spans 1.18 Mega bases. The maximum multipoint LOD scores are of 3.5 over the total of 10 markers. Evidence for the same ...

S10-spc-? is a 17.5 kb cluster of 32 genes encoding ribosomal proteins. This locus has an unusual composition and organization in Leptospira interrogans. We demonstrate the highly conserved nature of this region among diverse Leptospira and show its utility as a phylogenetically informative region. Comparative analyses were performed by PCR using primer sets covering the whole ...

An association has been observed in several independent data sets between late onset Alzheimer`s disease (AD) and the APOE locus on chromosomes 19. We have examined the genotype in family history positive (FHP) and family history negative (FHN) cases and find a distortion of the APOE allele frequencies in accord with previous studies. However, when we ...

In Prunus, the self-incompatibility (S-) locus region is <70 kb. Two genes�the S-RNase, which encodes the functional female recognition component, and the SFB gene, which encodes the pollen recognition component�must co-evolve as a genetic unit to maintain functional incompatibility. Therefore, recombination must be severely repressed at the ...

This study tested components of a proposed model of child anxiety and examined the mediational roles of (1) maternal control behavior, (2) maternal external locus of control, and (3) child external locus of control in the association between maternal and child anxiety. Thirty-eight clinically anxious mothers and 37 nonanxious mothers participated along ...

Sexual reproduction of fungi is governed by the mating type (MAT) locus, a specialized region of the genome encoding key transcriptional regulators that direct regulatory networks to specify cell identity and fate. Knowledge of MAT locus structure and evolution has been considerably advanced in recent years as a result of genomic analyses that enable the ...

We have recently discovered that the nuclear matrix protein SAFB is an oestrogen receptor corepressor. Since it has become clear that many steroid receptor cofactors play important roles in breast tumorigenesis, we investigated whether SAFB could also be involved in breast cancer. To address this question, the gene locus was examined for structural alterations in breast cancer ...

The kernel K(P) of a simple polygon P with n vertices is the locus of the points internal to P from which all vertices of P are visible. Equivalently, K(P) is the intersection of appropriate half-planes determined by the polygon's edges. Although the inte...

Sexual reproduction of fungi is governed by the mating type (MAT) locus, a specialized region of the genome encoding key transcriptional regulators that direct regulatory networks to specify cell identity and fate. Knowledge of MAT locus structure and evolution has been considerably advanced in recent years as a result of genomic analyses that enable the ...

Sexual reproduction of fungi is governed by the mating type (MAT) locus, a specialized region of the genome encoding key transcriptional regulators that direct regulatory networks to specify cell identity and fate. Knowledge of MAT locus structure and evolution has been considerably advanced in recent years as a result of genomic analyses that enable the ...

The comimetic Heliconius butterfly species pair, H. erato and H. melpomene, appear to use a conserved Mendelian switch locus to generate their matching red wing patterns. Here we investigate whether H. cydno and H. pachinus, species closely related to H. melpomene, use this same switch locus to generate their highly divergent red and brown color pattern ...

The expansion and contraction of mammalian class I multigene families raises the issue as to what determines the loss or retention of family members. We propose that accumulating changes in regulatory regions result in the loss of expression of the gene products during times critical to selection, leading to the extinction of misregulated genes. The structures of promoter regions of MHC class I ...

The childhood-onset SMA locus has been mapped to chromosome 5q13, in a region bounded by the proximal locus, D5S6, and the closely linked distal loci, D5S112 and MAP1B. We now describe a highly polymorphic, tightly linked microsatellite marker (D5S435) that is very likely the closet proximal marker to the SMA locus. Multipoint linkage ...

BackgroundThe aim was to ascertain whether thrombocyte MAO (trbc-MAO) activity and depressed state are genetically associated with the MAO locus on chromosome X (Xp11.3 � 11.4). We performed novel sequencing of the MAO locus and validated genetic variants found in public databases prior to constructing haplotypes of the MAO locus in ...

The pattern of linkage disequilibrium between a disease locus and a set of marker loci has been shown to be a useful tool for geneticists searching for disease genes. Several methods have been advanced to utilize the pairwise disequilibrium between the disease locus and each of a set of marker loci. However, none of the methods take into account the ...

In this research, the effects of emotional intelligence on the academic procrastination and locus of control tendencies of a group of university students are investigated. The sample of this study consists of 435 university students including 273 female students and 162 male students who were randomly selected from the population of Selcuk University students. The age range of ...

In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region ...

In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region ...

BackgroundLipopolysaccharide (LPS) is a pathogen associated molecular pattern (PAMP) of animal and plant pathogenic bacteria. Variation at the interstrain level is common in LPS biosynthetic gene clusters of animal pathogenic bacteria. This variation has been proposed to play a role in evading the host immune system. Even though LPS is a modulator of plant defense responses, reports of interstrain ...

Fetal events and obstetric complications are associated with schizophrenia. Here we report the results of a family-based candidate-gene study that assesses the role of maternal-fetal genotype incompatibility at the RHD locus in schizophrenia. We adapted the case-parent-trio log-linear modeling approach to test for RHD maternal-fetal genotype incompatibility and to distinguish ...

BackgroundPolycomb group (PcG) proteins play a crucial role in cellular senescence as key transcriptional regulators of the Ink4a/Arf tumor suppressor gene locus. However, how PcG complexes target and contribute to stable gene silencing of the Ink4a/Arf locus remains little understood.Methodology/Principal FindingsWe examined the ...

In some families of flowering plants, a single self-incompatibility (S) locus prevents the fertilization of flowers by pollen from the same plant. Self-incompatibility of this type involves the interaction of molecules produced by the S locus in pollen with those present in the female tissues (pistil). Until recently, the pistil products of the S ...

Locus D22S278 at 22q12 has been implicated in schizophrenia by sib-pair analysis. In order to replicate these results, we performed the transmission test for linkage disequilibrium (TDT) in 113 unrelated schizophrenic patients and their 226 parents. Evidence for potential linkage disequilibrium was obtained between schizophrenia and allele 243 of the marker AFM 182xd12 at the ...

Disinhibition-dementia-parkinsonism-amyotrophy complex (DDPAC) is defined by familial adult-onset behavioral disturbance, followed by frontal lobe dementia, parkinsonism, and amyotrophy in variable proportions. A genetic etiology of DDPAC was suspected because of the familial clustering in family Mo, despite their wide geographic distribution. We have mapped the DDPAC locus to ...

Disinhibition-dementia-parkinsonism-amyotrophy complex (DDPAC) is defined by familial adult-onset behavioral disturbance, followed by frontal lobe dementia, parkinsonism, and amyotrophy in variable proportions. A genetic etiology of DDPAC was suspected because of the familial clustering in family Mo, despite their wide geographic distribution. We have mapped the DDPAC locus to ...

The immotile-cilia syndrome (ICS) is an autosomal recessive trait of congenital dismobility or even complete immobility of cilia in the ciliated epithelia (MIM 244400). Recurrent upper respiratory infections in early childhood are the most common clinical findings. Recently a disease locus was mapped by sib pair analysis in two unrelated families on 6p ...

The chromosome conformation capture technique is used to monitor intra- and intermolecular chromosomal associations. By introducing an adaptation of this technique, Ling and colleagues have identified an unexpected coassociation between two loci on separate chromosomes in mouse nuclei, the imprinted Igf2-H19 locus of chromosome 7 and the Wsb1-Nf1 locus of ...

The goal of this paper is to investigate the robust stability of the uncertain system based on the edge theorem and the Bhattacharyya and Keel algorithm. Firstly, the dynamic model for the system will be derived, then, Depending on the uncertainty, which appears in the elements of matrix A, the system will generates a set of interval matrices, secondly the procedures of the proposed algorithm to ...

This exploratory investigation examined the relationship between racial identity and perceived racism as predictor variables and perceptions of health status and health locus of control as criterion variables in a sample of 90 Black American women. Results of a canonical correlational analysis indicated a shared variance of 37% between these two sets of variables. This ...

Hereditary Spastic Paraplegia (HSP) is a clinically and genetically heterogeneous group of neurological disorders that are characterized by progressive spasticity of the lower extremities. We describe an extended consanguineous Saudi family in which HSP is linked to SPG18, a previously reported autosomal recessive locus, and show that it is associated with a nullimorphic ...

Previous linkage analyses of 19 cutaneous malignant melanoma/dysplastic nevi (CMM/DN) kindreds showed significant evidence of linkage and heterogeneity to both chromosomes 1p and 9p. Five kindreds also showed evidence of linkage (Z > 0.7) to both regions. To further examine these findings, we conducted two-trait-locus, ...