The binding of ({sup 3}H) gamma-aminobutyric acid (GABA) to seminal membranes of swines and rams was examined. Specific, GABA binding was demonstrated in both species, which showed the features of GABA{sub A} type receptors. The affinity of binding was similar in both ...

Gamma-Aminobutyric acid (GABA) is a key inhibitory neurotransmitter in the mammalian central nervous system. Two major categories of receptors, termed GABA(A) and GABA(B) are activated by the amino acid. Whereas GABA(A) receptors appear to be directly inv...

... is an agonist for part of the gamma- aminobutyric acid (GABA) receptor ... there is compelling evidence that inhibitory amino acids (GABA, glycine ...

Cerebellar and cerebrocortical A-type ?-aminobutyric acid (GABA(A)) receptors were examined in mice and rats. In wild-type mouse cerebellum, the agonists GABA and gaboxadol exerted heterogeneous displacement of [(3)H]ethynylbicycloorthobenzoate (EBOB) binding with nanomolar and submicromolar affinities. In mouse ...

The enantiomers of 3F-GABA were evaluated on GABA(C) receptors. Both enantiomers were agonists, with the (R)-enantiomer being an order of magnitude more potent. This result is consistent with a folded binding mode for GABA, a conclusion which suggests a different binding mode to that found in the related but ...

GABA is the principal inhibitory neurotransmitter in the CNS, and acts via GABA_A and GABA_B receptors. Recently, a novel form of GABA_A receptor mediated inhibition, termed �tonic� inhibition, has been ...

Menthol is a widely-used cooling and flavoring agent derived from mint leaves. In the peripheral nervous system, menthol regulates sensory transduction by activating TRPM8 channels residing specifically in primary sensory neurons. Although behavioral studies have implicated menthol actions in the brain, no direct central target of menthol has been identified. Here we show that menthol reduces the ...

(Fig. 2a). Fractional availability de- creased with increasing duration and concentration of the GABA., 1997). In our experiments, the concentration of GABA at hippocampal inhibitory synapses rose and postsynaptic receptors. We report here that low concentrations of GABA reduce IPSCs in hippocampal neurons

... 449 bp, encoding a subunit of the ?-aminobutyric acid (GABA)-activated chloride channel was isolated from Plutella ... GABA receptor, functional expression, Xenopus oocyte, abamectinThe ?-aminobutyric aci...

GABAergic amacrine cell feedback to bipolar cells in retina has been described, activating both GABA(A) and GABA(C) receptors. We explored whether metabotropic GABA(B) receptors also participate in this feedback pathway. CGP55845, a potent GABA(B) ...

The effect of gamma-aminobutyric acid (GABA) on the bull sperm acrosome reaction was evaluated, and the interaction of progesterone, a physiologic inducer of the acrosome reaction, with the GABA receptor was explored. The acrosome reaction was stimulated by GABA in a dose-dependent manner. This effect was inhibited ...

GABAergic feedback inhibition from amacrine cells shapes visual signaling in the inner retina. Rod bipolar cells (RBCs), ON-sensitive cells that depolarize in response to light increments, receive reciprocal GABAergic feedback from A17 amacrine cells and additional GABAergic inputs from other amacrine cells located laterally in the IPL. The circuitry and synaptic mechanisms underlying lateral ...

... These neuroexcitatory GABA blockers include pentylenetetrazol, chlorinated hydrocarbon insecticides like dieldrin and lindane, and the synthetic ...

... for two important inhibitory neurotransmitters: serotonin and gamma-aminobutyric acid (GABA). Other receptors with links to myoclonus include ...

Gamma-aminobutyric acid A (GABA_A) receptors are the principal mediators of synaptic inhibition, and yet when intensely activated, dendritic GABA_A receptors excite rather than inhibit neurons. The membrane depolarization mediated by GABA_A receptors is a result of the ...