The emptying of the gallbladder was studied in 13 patients submited to truncal vagotomy, 14 to selective vagotomy, associated to hemi-gastrectomy and reconstruction of the digestive tract through gastroduodenostomy; 15 pacients submited to proximal gastri...
National Technical Information Service (NTIS)
Considerable differences on the frequencies of the mitochondrial 12S rRNA A1555G and tRNA(Ser(UCN)) A7445G mutations have been reported in different populations. Our screening of 168 patients coming from independent Turkish families with prelingual sensorineural non-syndromic deafness revealed three deaf children with A1555G (1.8%) but ...
PubMed
ObjectiveTo investigate the role of mitochondrial modifiers in the development of deafness associated with 12S rRNA A1555G mutation.MethodsFour Chinese families with nonsyndromic and aminoglycoside-induced deafness were studied by clinical and genetic evaluation, molecular and biochemical analyses of mitochondrial DNA ...
PubMed Central
Mutations in the mitochondrial DNA have been found to be one of the most important causes of sensorineural hearing loss. In particular, these mutations often occur in the mitochondrial 12S rRNA and tRNA genes. Of these, the homoplasmic A1555G and C1494T mutations in the 12S rRNA have been associated with both aminoglycoside induced and ...
Mutations in mitochondrial 12S rRNA gene are one of the most important causes of aminoglycoside-induced and nonsyndromic hearing loss. Here we report the characterization of one Han Chinese pedigree with aminoglycoside-induced and nonsyndromic hearing loss. This Chinese family carrying the 12S rRNA A1555G mutation exhibited high ...
The A1555G mutation in the mitochondrial small ribosomal RNA gene (12S rRNA) has been associated with aminoglycoside-induced, nonsyndromic hearing loss. However, the clinical phenotype of A1555G carriers is extremely variable. In the present study, we have performed an audiological evaluation of a group of deaf patients and hearing carriers of mutation ...
Co-occurrence of double pathogenic mtDNA mutations with different claimed pathological roles in one mtDNA is infrequent. It is tentative to believe that each of these pathogenic mutations would have its own deleterious effect. Here we reported one three-generation Chinese family with a high penetrance of LHON (78.6%). Analysis of the complete mitochondrial genome in the proband revealed the ...
In order to evaluate the role of the clearance of 99 m Technetium chelated to diethylenetriamine-penta-acetate (99 m Tc-DTPA) in amiodarone induced pulmonary disease, 40 individuals were studied in four groups. After spirometry, where a volume-time curve ...
Serum thyroglobulin (Tg) response to bovine TSH (bTSH) was evaluated in 44 goitrous patients (grades II and III), living in conditions of chronic iodine (I) deficiency (iodine urinary excretion
Fifteen patients carrier hypophyseal adenomas, with ages varying between 16 to 53 years were studied. The patients presented sella changes to the conventional plane radiographies and were submited a surgery treatment, with access to hypophysis by the tran...
The behaviour of T and B lymphocytes subpopulations was evaluated in patients with breast cancer submitted to 3 different schedules of radiotherapy. The assays were carried out before and immediately after the end of treatment. T lymphocytes and the helpe...
OBJECTIVE:: To analyze the prevalence and importance of the maternally inherited A1555G mutation in the 12S rRNA gene in the Austrian population. STUDY DESIGN:: Investigation for mutations of genetically affected familial and sporadic cases of hearing impairment (HI), including analyses of audiometric data. SETTING:: Teaching hospital, ...
The most common mutation associated with aminoglycoside-induced deafness is A1555G and it has been found in diverse populations worldwide. In the present study we investigated a large South African family known to harbour A1555G. A total of 97 family members were genotyped using the SNaPshot technique and 76 were found to be ...
Despite the fact that important genetic diseases are caused by mutant mitochondrial ribosomes, the molecular mechanisms by which such ribosomes result in a clinical phenotype remain largely unknown. The absence of experimental models for mitochondrial diseases has also prevented the rational search for therapeutic interventions. Here, we report on the construction of bacterial hybrid ribosomes ...
Este estudo avalia quanto o corpo m�dico do Hospital Dr. Dar�o Contreras de Rep�blica Dominicana conhece, respeita, informa e aplica a Lei Geral de Sa�de em rela��o aos direitos do paciente Testemunha de Jeov� de negar-se a ser transfundido (respeito a sua autonomia); tamb�m se os Testemunhas de Jeov� conhecem a Lei Geral de Sa�de e ...
We report here the clinical, genetic and molecular characterization of a large Han Chinese family with aminoglycoside induced and nonsyndromic hearing loss. The penetrance of hearing loss (affected matrilineal relatives/total matrilineal relatives) in this pedigree was 53%, when aminoglycoside-induced deafness was included. When the effect of aminoglycosides was excluded, the penetrance of hearing ...
The objective of this study was to develop a real-time amplification refractory mutation system-quantitative PCR (RT-ARMS-qPCR) assay for quantitation of mitochondrial DNA (mtDNA) with a mutated 1555 site and to explore the relationship between the degree of mtDNA1555 mutation and the clinical phenotype of mitochondrial deafness. An amplified mtDNA fragment containing the 1555 site was ligated ...
The pituitary and peripheral response to L-T4 and L-T3 therapy were studied in 12 patients with congenital goitrous hypothyroidism, in 10 patients with an ectopic thyroid and onset of hypothyroidism at 3-8 years of age, and in 6 patients with adult-onset ...
We report here on the clinical, genetic, and molecular characterization of three Han Chinese pedigrees with aminoglycoside-induced and nonsyndromic hearing loss. Clinical evaluation revealed the variable phenotype of hearing impairment including severity, age-at-onset, audiometric configuration in these subjects. The penetrance of hearing loss in WZD8, WZD9, and WZD10 pedigrees were 46%, 46%, and ...
The proposal of this job was to study cephalo-facio-dental patterns comparatively in patients who presented normal occlusion and Class II, division 1 malocclusions, considering variations of the FMA angle. The sample was composed of seventy-five telerradi...
The absorption of radioactive vitamin B/sub 1//sub 2/ was studied in subtotal gastrectomized patients with either Billroth I or Billroth II anastomosis and in total gastrectomized patients. The results were compared with absorption in a control group of non-gastrectomized patients. Absorption was evaluated through fecal excretion using the Halsted technique and through urinary ...
Energy Citations Database
Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. We report here the clinical, genetic and molecular characterizations of seven Han Chinese pedigrees with aminoglycoside-induced and nonsyndromic bilateral hearing loss. Clinical evaluation revealed the variable phenotype of hearing impairment including severity, age-at-onset and audiometric ...
We report here on the characterization of a three-generation Chinese family with aminoglycoside-induced and nonsyndromic hearing impairment. Ten of 17 matrilineal relatives exhibited bilateral and sensorineural hearing impairment. Of these, nine matrilineal relatives, who had a history of exposure to aminoglycosides, exhibited variable severity and audiometric configuration of hearing loss. The ...
For each positive integer n, let Fn be a free group of rank n with basis (in other words, free generating set) {x1, �, xEM>n>} . If [theta] is an automorphism of <EM>Fn> then {<EM>x>1[theta], �, ...
NASA Astrophysics Data System (ADS)
Hearing impairment is the most prevalent sensorial deficit in the general population. Congenital deafness occurs in about 1 in 1000 live births, of which approximately 50% has hereditary cause in development countries. Non-syndromic deafness can be caused by mutations in both nuclear and mitochondrial genes. Mutations in mtDNA have been associated with aminoglycoside-induced and non-syndromic ...
We hereby report on the audiological and genetic findings in individuals from a Brazilian family, with the following mitochondrial mutation A1555G in the 12SrRNA gene (MT-RNR-1). Nine individuals underwent speech, audiologic (tonal audiometry and logoaudiometry) and genetic evaluations. Eight individuals among the A1555G carriers were ...
Pathogenic mitochondrial DNA mutations are most often implicated in inherited and acquired hearing impairment. The current review mainly focuses on the 12S rRNA mitochondrial gene mutations associated with non-syndromic deafness without or after aminoglycosides exposure. Aminoglycoside-induced and nonsyndromic deafness has been shown to have a genetic susceptibility and the pathogenic ...
Severe to profound hearing impairment (HI) is estimated to affect around 1/2000 young children. Advances in genetics have made it possible to identify several genes related to HI. This information can cast light upon prognostic factors regarding the outcome in cochlear implantation, and provide information both for scientific and genetic counselling purposes. From 1992 to 2005, 273 children from ...
de los signos más obvios de la enfermedad es la incapacidad de mover adecuadamente los ojos. Algunos pacientes describen este efecto como una imagen borrosa. Los pacientes con PSP...
Science.gov Websites
El carcinoma hepatocelular está relacionado con cirrosis en 50 a 80% de los pacientes, 5% de los pacientes cirróticos eventualmente desarrollan cáncer hepatocelular, que a menudo es multifocal.
Cancer.gov
El manejo médico de la hipercalcemia resulta fundamental, especialmente para los pacientes con enfermedad irresecable o sin enfermedad mensurable, y debe ser la meta inicial del tratamiento de todos los pacientes con HPT.
Los investigadores descubrieron que alrededor del 97 por ciento de los pacientes del estudio a los que se administró imatinib durante un año después de la cirugía no padecieron una recidiva de su cáncer, en comparación con el 83 por ciento de los pacientes a los que se administró el placebo durante ese año. Además, la mayoría de los ...
Los familiares a cargo de la atenci�n de pacientes de c�ncer pueden ser c�nyuges, parejas, hijos, parientes o amigos que ayudan al paciente en las actividades de la vida diaria y las necesidades de atenci�n de la salud en el hogar.
The aim of this study was to replicate, in patients with multiple sclerosis (MS), the three-cluster cognitive-behavioral classification proposed by Turk and Rudy. Sixty-two patients attending a tertiary MS rehabilitation center completed the Pain Impact Rating questionnaire measuring activity interference, pain intensity, social support, and emotional distress. The General Health Questionnaire-28 ...
Pensar en la etapa final de la vida y planificarla puede ser un período difícil para los pacientes y sus familias. Cada persona tendrá necesidades únicas y las enfrentará de diferentes maneras. Este tiempo se hace más fácil cuando los pacientes, las familias y los proveedores de atención de la salud hablan abiertamente sobre los planes para la ...
El cáncer del esófago es una enfermedad tratable pero raras veces curable. La supervivencia general a cinco años en los pacientes idóneos para ser sometidos a un tratamiento definitivo es de 5 a 30%. De vez en cuando se presenta un paciente con la enfermedad en su estadio muy inicial que tiene mejor oportunidad de supervivencia. Los ...
Los resultados preliminares de un estudio cl�nico grande con asignaci�n al azar de pacientes de 16 a 60 a�os de edad con leucemia mieloide aguda (LMA), un c�ncer de la sangre y de la m�dula �sea, que no hab�a sido tratada anteriormente, muestran que los pacientes que recibieron una alta dosis de daunorrubicina, un f�rmaco de quimioterapia ...
, problemas en las conjunturas Defectos del Corazon Anemia, Anemia falciforme, hemofilia Fibrosis Quistica
E-print Network
Este sumario para pacientes sobre el cese del hábito de fumar y el riesgo persistente en el paciente de cáncer es una adaptación del sumario escrito por los expertos en cáncer para los profesionales de la salud. �sta y otra información fidedigna sobre el tratamiento del cáncer, su detección y prevención, el cuidado médico de apoyo brindado a los ...
It is a classical result of Postnikov [15] that homotopy types X with at most two non-trivial homotopy groups [pi]mX = A and [pi]n<EM>X> = <EM>B>, 2 [less-than-or-eq, slant] <EM>m> < <EM>n>, are classified by the ...
The theory of reductive monoids has been well developed by Renner and the author, cf. [8, 13]. This paper concerns the finite reductive monoids MF where M is a reductive monoid and F[ratio]MEM>[rightward arrow]<EM>M> is a Frobenius map. We show that the Deligne-Lusztig characters ...
Mitochondrial DNA (mtDNA) mutations play an important role in etiology of hereditary hearing loss. In various regions of the world, patients suffer from nonsyndromic sensorineural hearing loss initiated by aminoglycoside antibiotics. Mutations that had been shown as pathogenetically important for hearing function disturbance were identified in mitochondrial 12S rRNA and tRNA(Ser(UCN)) genes while ...
We report here the clinical, genetic and molecular characterization of one three-generation Han Chinese family with Leber's hereditary optic neuropathy (LHON) and hearing loss. Four of 14 matrilineal relatives exhibited the moderate central vision loss at the average age of 12.5 years. Of these, one subject exhibited both LHON and mild hearing impairment. Sequence analysis of the complete ...
The mitochondrial DNA (mtDNA) 12S rRNA is a hot spot for mutations associated with both aminoglycoside-induced and nonsyndromic hearing loss. Of those, the homoplasmic A1555G and C1494T mutations at a highly conserved decoding region of the 12S rRNA have been associated with hearing loss. These two mutations account for a significant ...
ERIC Educational Resources Information Center
The homoplasmic mitochondrial A1555G mutation in the 12S rRNA gene leads to a mitochondrial translation disorder associated with deafness. The absence of disease in non-cochlear tissues in all patients, and in the cochlea in some patients, is not well understood. We used a system-based approach, including whole genome expression and ...
We explored the mitochondrial 12S rRNA and the tRNA{sup Ser(UCN)} genes in 100 Tunisian families affected with NSHL and in 100 control individuals. We identified the mitochondrial A1555G mutation in one out of these 100 families and not in the 100 control individuals. Members of this family harbouring the A1555G mutation showed ...
Mutations in mitochondrial DNA is one of the important causes of hearing loss. Here, we performed a mutational screening of tRNA(Ser(UCN)) gene in 1542 Chinese subjects with hearing loss. One subject and five subjects carried tRNA(Ser(UCN)) A7445C and G7444A mutations, respectively, while two subjects harbored both G7444A and 12S rRNA ...
We report here the characterization of a large Chinese family with maternally transmitted aminoglycoside-induced and nonsyndromic deafness. In the absence of aminoglycosides, some matrilineal relatives in this family exhibited late-onset/progressive deafness, with a wide range of severity and age at onset. Notably, the average age at onset of deafness has changed from 55 years (generation II) to ...
Mutations at the DFNB1 locus which encode connexin 26 (CX26) and connexin 30 (CX30) proteins, respectively, are main cause for sporadic and familial non-syndromic hearing impairment (NSHI) in many populations. 342-kb deletion [del (GJB6-D13S1830)] of Cx30 gene is second most common connexin mutation. Specific mitochondrial DNA (mtDNA) mutations have been found to be associated with NSHI. In this ...
A known side effect of aminoglycoside antibiotics is the development of permanent hearing loss. As South Africa is currently facing a tuberculosis (TB) epidemic, with an increasing number of multi-drug resistant tuberculosis (MDR-TB) infections, the use of aminoglycosides is on the increase. It is therefore important to determine whether the mitochondrial mutations associated with ...
The mitochondrial 12S rRNA A1555G mutation is one of the important causes of aminoglycoside-induced and nonsyndromic hearing loss. Here we employed an RNA-directed chemical-modification approach to understanding the pathogenesis of aminoglycoside-induced hearing loss. The patterns of chemical modification of RNA oligonucleotides ...
Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. We report here the clinical, genetic, and molecular characterization of 16 Chinese pedigrees (a total of 246 matrilineal relatives) with aminoglycoside-induced impairment. Clinical evaluation revealed the variable phenotype of hearing impairment including audiometric configuration in these ...
Mitochondrial biogenesis is controlled by signaling networks that relay information to and from the organelles. However, key mitochondrial factors that mediate such pathways and how they contribute to human disease are not understood fully. Here we demonstrate that the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 are key downstream effectors of mitochondrial ...
We reported here the clinical and molecular characterization of a Chinese subject with childhood-onset hearing impairment. Clinical evaluations showed that the patient suffered from profound and non-syndromic sensorineural hearing loss with flat configurations. Sequence analysis of the mitochondrial 12S rRNA and tRNA(Ser(UCN)) genes led to the identification of double deafness-associated mutations ...
OBJECTIVE: The purpose of this study was to determine the prevalence of mutations in the GJB2 gene, the GJB6-D13S1830 deletion and the four common mitochondrial mutations (A1555G, A3243G, A7511C and A7445G) in a South African population. METHODS: Using single-strand conformation polymorphism and direct sequencing for screening GJB2 ...
The size of von Willebrand factor (VWF), controlled by ADAMTS13-dependent proteolysis, is associated with its hemostatic activity. Many factors regulate ADAMTS13-dependent VWF proteolysis through their interaction with VWF. These include coagulation factor VIII, platelet glycoprotein 1b?, and heparin sulfate, which accelerate the cleavage of VWF. Conversely, thrombospondin-1 decreases the rate of ...
AIM: The aim of this study was to assess the quality of life (QoL) in patients with multiple sclerosis (MS), and to evaluate its association with disability and psychosocial factors especially depression and fatigue. METHODS: Demographic characteristics, education level, disease severity, and disease duration were documented for each patient. QoL, fatigue level, cognitive status, and depression ...
We compute the (uni)versal deformation ring of an odd Galois representation [rho]: Gal (M/Q) [rightward arrow] Gl2(Fp) with an upper triangular image, where MEM> is the maximal abelian pro-<EM>p>-extension of <EM>F>[infty infinity] unramified outside a finite set of places ...
Placa de estudio anatomopatológico que muestra el tipo más común de cáncer de páncreas, el adenocarcinoma. Menos del 5 por ciento de los pacientes con la enfermedad diagnosticada viven más de 5 años.
Sitio web para pacientes : www.cancer.net E N L A C E e n t r e pacientes con cáncer y s u s m é d i c o s e n u n a c a t á s t r o f e Para ayuda durante una catástrofe natural o nacional cuando usted no puede ponerse en contacto con su
Este sumario sobre la náusea y el vómito para pacientes, es una adaptación del sumario escrito para profesionales de la salud, por expertos en cáncer. Este breve sumario describe las causas y el tratamiento de la náusea y el vómito, dos de los efectos secundarios más perturbadores para los pacientes de cáncer.
Los familiares que cuidan del paciente desempeñan una función importante en el manejo del cáncer; contar con su cooperación e incluirlos como núcleo de la atención médica desde el principio, se consideran ingredientes fundamentales para el tratamiento eficaz del cáncer.
El diagnóstico de un tumor primario oculto sólo se determina si no se detecta un tumor primario después de una búsqueda cuidadosa. Se excluye a los pacientes con metástasis en los ganglios linfáticos cervicales que se relacionan histológicamente con un tumor primario tratado previamente y a los pacientes con linfomas y adenocarcinomas.
El cáncer del estómago distal localizado se puede curar en más del 50% de los pacientes. Sin embargo, actualmente la enfermedad en estadio inicial sólo representa del 10 al 20% de todos los casos diagnosticados en los Estados Unidos. Los demás pacientes padecen de enfermedad metastásica en sitios regionales o distantes.
En el momento del diagnóstico, aproximadamente 30% de los pacientes de CPCP tendrán tumores confinados al hemitórax de origen, el mediastino o los ganglios linfáticos supraclaviculares. Se clasifica a estos pacientes con enfermedad en estadio limitado (EL) y la mayoría de los supervivientes sin enfermedad a los dos años pertenecen a este grupo.
La comunicación entre los médicos y los pacientes es un concepto multidimensional e incluye el contenido del diálogo, el componente afectivo (es decir, lo que les sucede emocionalmente al médico y al paciente durante el encuentro) y los comportamientos no verbales.
El médico, la enfermera o el asistente o trabajador social pueden proveer información acerca de las necesidades específicas del paciente, de la disponibilidad de servicios de atención domiciliaria y una lista de las agencias locales que proveen dichos servicios.
EMS Review A review of the Wallops EMS, following EMS audit principles and .... accordance with WFF-EM-002, Wallops EMS Training Manual, located at: ...
NASA Website
Management Systems (EMS) EMS Basic Information EMS Training EMS Success Stories Waste Management Related Initiatives Waste Environmental Management Systems (EMS) Environmental...
The low-Reynolds-number collision and rebound of two rigid spheres moving in an ideal isothermal gas is studied in the lubrication limit. The spheres are non-Brownian in nature with radii much larger than the mean-free path of the molecules. The nature of the flow in the gap between the particles depends on the relative magnitudes of the minimum gap thickness, h[prime prime or minute]o, the ...
Stably stratified flows past three-dimensional orography have been investigated using a stratified towing tank. Flows past idealized axisymmetric orography in which the Froude number, Fh=U/Nh (where U is the towing speed, N is the buoyancy frequency and hEM> is the height of the obstacle) is less than unity have been studied. The orography considered consists of two ...
We show that the sequence 2n+n is a universal Hilbert sequence. That is, for each polynomial P(T, Y) irreducible in [open face Q](T) [YEM>], the polynomial <EM>P>(2<EM>n+n>, <EM>Y>) is irreducible in [open face ...
For E a subset of [open face R]n and s [set membership] [0, n] we define upper and lower box dimension profiles, B-dims<EM>E> and B-dim<EM>sE> respectively, that are closely related to the box dimensions of the orthogonal projections of <EM>E> onto ...
Los trastornos cognitivos y el delirio son trastornos en los que el paciente experimenta un estado de confusión mental y cambios en la conducta.
Resumen de información revisada por expertos acerca del trastorno de tensión postraumática en los pacientes con cáncer, sobrevivientes del cáncer y miembros de la familia. Se discuten la evaluación y tratamiento de este trastorno.
Hoja informativa que contiene una lista de organizaciones que brindan apoyo financiero y emocional, intercesión e información a pacientes con cáncer y a sus familias.
promover el crecimiento de la piel en las víctimas de quemados,restaurar la visión en ojos dañados o crear nuevos órganos para pacientes que necesitan un trasplante....
Es un tratamiento común contra el cáncer. Usa dosis (cantidades) altas de radiación para destruir las células cancerosas. También reduce el tamaño de los tumores.
Informaci�n para personas que necesitan entender c�mo funciona la braquiterapia (un tipo de radioterapia interna).
... Esta fecha les da a los pacientes tiempo para que hablen con su médico y se cambien a otro medicamento para tratar su asma. 3. ¿Qué ...
Center for Drug Evaluation (CDER)
... ambiente. Esta fecha les da a los pacientes tiempo para que hablen con su médico y se cambien a otro medicamento para tratar su asma. ...
información general sobre la visión saludable. Un oculista quien ha examinado los ojos del paciente y está familiarizado con su historia médica es la persona más apropiada...
Mujeres Folletos para el paciente Resúmenes Estrés: Cómo afrontar los retos de la vida(Academia Americana de Médicos de Familia) También está disponible en inglés Estrés...
El cáncer es un sistema renegado de crecimiento que se origina dentro del biosistema de un paciente, más comúnmente conocido como el cuerpo humano.
Del mismo modo que los pacientes necesitan evaluación constante en relación con la depresión y la ansiedad en el curso del tratamiento, también es necesaria para los familiares a cargo de la atención.
para el paciente Cuando usted se enferma a causa de la diabetes Cuidado de los ojos en caso de diabetes Cuidado de los pies en caso de diabetes Diabetes tipo 2 - qué...
Esta serie de hojas sobre consejos para los efectos de la quimioterapia contiene recomendaciones m�dicas y sugerencias pr�cticas para ayudarle durante la quimioterapia.
... La FDA revisó un ensayo clínico aleatorio realizado para evaluar la eficacia y seguridad de Chantix en 460 pacientes de al menos 35 años de edad con EPOC ...
... Los profesionales del cuidado de salud deben estimular a los pacientes a que lean la Gu�a de medicamentos que viene con su receta para un bloqueador de TNF?. ...
La buena comunicación entre los pacientes de cáncer, los familiares que los cuidan y el equipo de atención de salud es muy importante para la atención del cáncer.
... y con el National Council on Patient Information and Education (Concilio Nacional de Información y Educación al Paciente) www.talkaboutrx.org ...
Las complicaciones gastrointestinales (estreñimiento, retención fecal, obstrucción intestinal, diarrea y enteritis por radiación) son problemas comunes en el paciente de oncología. El crecimiento y la propagación del cáncer, así como su tratamiento, contribuyen a estas afecciones.
en el paciente Abstinencia de nicotina Teofilina u otros medicamentos Deficiencia de vitamina B6 La agitación también puede ocurrir con trastornos cerebrales o de salud...
... NO EVITAR� que otras personas se contagien. El diagn�stico del paciente debe ser responsabilidad del m�dico al igual que el uso de antibi�ticos. ...
