... this website will be limited. Search Help? Alpha-1 Antitrypsin Also known as: Alpha 1 -antitrypsin; A1AT; ... deficiency? How common is alpha-1 antitrypsin deficiency? 1. What can I do to take care of ...

The integrity of lung alveoli is maintained by proper circulating levels of ?-1 antitrypsin (A1AT). Next to cigarette smoking, A1AT deficiency is a major risk factor for lung emphysema development. We recently reported that in addition to neutralizing ...

Background Alpha-1-antitrypsin (A1AT) deficiency is the only recognised genetic risk factor for chronic obstructive pulmonary disease (COPD), a leading cause of morbidity and mortality worldwide. Since A1AT is the major inhibitor of neutrophil elastase ...

Human alpha-1-antitrypsin (A1AT) is a protease inhibitor that is involved in the protection of lungs from neutrophil elastase enzyme that drastically modifies tissue functioning. The glycoprotein consists of 394 amino acids and is N-glycosylated at Asn-46, Asn-83, and Asn-247. ...

Alpha-1 antitrypsin (A1AT) is a 52 kDa serine protease inhibitor that is synthesized in and secreted from the liver. Although it is present in all tissues in the body the present consensus is that its main role is to inhibit neutrophil elastase in the lung. A1AT ...

Alpha-1-antitrypsin (A1AT) is an important inhibitor of neutrophil proteases including elastase, cathepsin G, and proteinase 3. Transcription profiling data suggest that A1AT is expressed by human neutrophil granulocytes during all developmental stages. A1AT has hitherto ...

BackgroundAlpha-1 antitrypsin (A1AT) deficiency, caused by the Z allele (p.E342K) and S allele (p.E264V) in the SERPINA1 gene, can induce liver and pulmonary disease. Different mechanisms appear to be responsible for the pathogenesis of these divergent disease expressions. The c.-1973T >C polymorphism located in ...

In a previous study, alpha-1-antitrypsin (A1AT) deficiency alleles were found to be over represented among individuals with microsatellite unstable (MSI-high) colorectal cancers, and this was most significant in former or current smokers. We evaluated this association in a larger case-control study, stratified by ...

a1-Antitrypsin and a1-Antichymotrypsin were demonstrated by the peroxidase--antiperoxidase (PAP) technique in paraffin sections from various parts of the normal adult gastrointestinal tract. Thus, positive reaction for these two proteinase inhibitors was given by the absorptive epithelial cells of the small intestine and epithelial cells of Br�nner's duodenal glands and the glands of the pyloric ...

We characterized the elastase and antielastase activity of the alveolar fluid of seven patients with the adult respiratory distress syndrome (ARDS) and thirteen normal volunteers. Alpha-1-antitrypsin (A1AT) concentrations were 60-fold higher in ARDS as compared to normal lavage fluid (2,140 +/- 498 nM; 36.1 +/- 4.2 ...

BackgroundExocrine tissue is commonly cotransplanted with islets in autografting and allotransplantation of impure preparations. Proteases and insulin are released by acinar cells and islets, respectively, during pretransplantation culture and also systemically after transplantation. We hypothesized that released proteases could cleave insulin molecules and that addition of alpha 1 antitrypsin ...

Alpha-1-antitrypsin (A1AT) deficiency is characterized by increased neutrophil elastase (NE) activity and oxidative stress in the lung. We hypothesized that NE exposure generates reactive oxygen species by increasing lung non-heme iron. To test this hypothesis, we measured bronchoalveolar lavage (BAL) iron and ...

... Accession Number : AD0711584. Title : COMPARATIVE STUDY OF ANTIMALARIAL AND OTHER DRUGS ON G6PD DEFICIENT RED CELLS. ...

... and tumor tissues, and to compare DNA repair capacities in neurofibromin- deficient Schwann cells and Schwann cell-derived tumor cell lines. 15. ...

This report summarizes studies on 55 immune deficient subjects (including selective IgA deficiency, Agammaglobulinemia, Variable immunodeficiency and Hypergammaglobulinemia). An equal number of sex- and age-matched controls were compared for oral disease ...

The report compares current methods of testing congenital color deficiencies with tests designed to employ color video display units (VDUs). Twelve persons with congential color vision deficiencies were asked to judge and match colors presented on a full ...

Fatty acids and other components of the diet may modulate, among others, mechanisms involved in homeostasis, aging, and age-related diseases. Using a proteomic approach, we have studied how dietary oil affected plasma proteins in young (6�months) or old (24�months) rats fed lifelong with two experimental diets enriched in either sunflower or virgin olive oil. After the depletion of the most ...

Ten protein coding loci (6-PGD, A1-AT, ACP1, CaII, ESD, GC, GPX1, Hb beta, PGM1, and TF) were analyzed in the Mbenzele Pygmies from the Central African Republic. The frequency data were used to calculate the genetic distances between Mbenzele Pygmies and other African groups. In the principal coordinate plot of FST genetic distances, ...

Metabolic responses of the new neuronal human cell line AGE1.HN to various substrate levels were analyzed in this study showing that reduced substrate and especially pyruvate load improves metabolic efficiency, leading to improved growth and ?(1)-antitrypsin (A1AT) production. The adaptation of the metabolism to different pyruvate and ...

The effects of the heavy metal Cd in Malus xiaojinensis were investigated using hydroponic cultures. Chlorophyll and Fe concentrations in young leaves were markedly decreased by Cd treatment, although Fe concentration was significantly enhanced in the roots. A comparative examination of the Fe-deficiency responses due to Fe deficiency ...

... blocked in comparably treated DNA repair-deficient mice (ie ... Subject Categories : TOXICOLOGY CHEMICAL, BIOLOGICAL AND RADIOLOGICAL ...

... Accession Number : ADA030154. Title : Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells. ...

... Accession Number : ADA008460. Title : Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells. ...

... Accession Number : AD0775475. Title : Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells. ...

... Accession Number : AD0753957. Title : Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells. ...

... Accession Number : AD0730759. Title : Comparative Study of Antimalarial and Other Drugs on G6PD Deficient Red Cells. ...

Granulocytes contain large quantities of ascorbic acid (AA). The uptake mechanism is mainly restricted to the accumulation of the oxidized form, dehydroascorbate (DHA). We investigated the uptake of ascorbic acid and dehydroascorbate of normal, myeloperoxidase (MPO)-deficient, and NADPH-oxidase-deficient granulocytes. The accumulation of ascorbic acid was ...

To identify the proteins induced by Fe deficiency, we have compared the proteins of Fe-sufficient and Fe-deficient barley (Hordeum vulgare L.) roots by two-dimensional polyacrylamide gel electrophoresis. Peptide sequence analysis of induced proteins revealed that formate dehydrogenase (FDH), adenine phosphoribosyltransferase, and ...

In this paper we compare the superconductive transition of several oxygen deficient samples measured inductively to that measured resistively and point out important systematic differences between the results of the two types of measurements. Fully oxygen...

Polygraphic night recordings were obtained in 43 mentally deficient patients and were compared to these of 28 normal subjects. The percentage of paradoxical sleep is significantly diminished (P

Studies were made on the effects of undernutrition at different ages during the neonatal period and of the comparative effects of postweaning protein and calorie deficiencies in neonatally undernourished or normally reared animals. Neonatal undernutrition...

Tomato seeds deficient in most of the elements known to be essential for higher plants were tested for their sensitivity to gamma radiation. In the first generation leaf length was used as an index of radiatlon sensitivity; zinc deficlent seeds we e much more radiosensitive than controls, as to a lesser xtent were seeds deficient in copper, ...

The effects of riboflavin deficiency on hepatic peroxisomal and mitochondrial palmitoyl-CoA oxidation were examined in weanling Wistar-strain male rats. The specific activities of peroxisomal catalase and palmitoyl-CoA-dependent NAD+ reduction were not affected by up to 10 weeks of riboflavin deficiency. In contrast, the specific activity of mitochondrial ...

BACKGROUND: It has recently been suggested that primary lactase deficiency might have been selected for by malaria, as has been previously shown to occur for thalasaemia and glucose 6-phosphate dehydrogenase (G6PD) deficiency. AIMS: To test this hypothesis, the prevalence of primary lactase deficiency in G6PD ...

Deficiency in several trace elements, including copper and selenium, is associated with increased levels of oxidative stress. Copper deficiency also has been shown to impair immune function. Previous work by others demonstrated that passage of an amyocarditic or myocarditic strain of coxsackievirus B3 (CVB3) through selenium- or vitamin ...

The copper-deficient rat-trypanosome system was used to study copper deficiency in Sprague Dawley rats infected with Trypanosoma lewisi. Throughout the observational period, animals on the deficient diet had lower plasma and liver copper concentrations compared with complete and pair-fed animals. In all dietary ...

Vitamin B12-deficiency may induce specific symptoms as neurological alterations and unspecific symptoms such as anaemia and growth retardation. In this study, maternal vitamin B12 deficiency from end of gestation to weaning was evaluated in mouse dams, which was provoked by feeding a vitamin B12-deficient diet. The animals were divided ...

Since experimental Se deficiency results in a significant increase in plasma cholesterol concentration the present investigation was undertaken to assess further the influence of this deficiency on the expression of proteins involved in hepatic lipid metabolism. Se deficiency was induced by feeding weanling male Wistar rats on a ...

... Abstract : The atmosphere of Venus appears to be deficient in water vapor by a factor of about 10,000 compared with the total amount of water on ...

... often associated with immune stimulation. Comparing the feed conversion ratio, the control diet group had better feed efficiency ... ...

Growth Hormone Deficiency (GHD); Turner Syndrome; Small for Gestational Age (SGA); Chronic Renal Insufficiency (CRI)

... To address this question, we compared the killing of germination-proficient (gp) and germination-deficient ( gerH) Sterne 34F2 strain spores by ...

... disease: Follow-up of a randomized controlled trial ... Reliability of symptoms in assessing control of gastric ... deficient mice compared to wild-type (WT) controls. ...

... rays for small samples of Be, C, N, H2O ... and gamma-ray production cross sections when compared ... in terms of specific cross-section deficiencies at ...

... deficient LNCaP cells, and comparing these cells to constitutively expressing NQ01 cells, with or without inhibitors of the enzyme (ie, dicoumarol) . ...

The hypothesis that age- and tissue-specific differences in choline metabolism is differentially affected by folate deficiency (FD) was tested by comparing choline and acetylcholine levels in male Sprague Dawley rats, who were fed for 10 weeks either a control diet or a folate deficient diet startin...

African Americans have higher rates of type 2 diabetes and some forms of cardiovascular disease (CVD) compared with European Americans. They also have much higher rates of vitamin D deficiency. There is emerging evidence that vitamin D deficiency may be a risk factor for hypertension, type 2 diabete...

Tetracycline alone, at daily dosages of 1 g, has no hemolytic effects on G6PD deficient red blood cells of the B- type. Amodiaquine also, at the usual dosages, is not harmful for enzyme deficient red cells. Amodiaquine and tetracycline, given in successio...

The studies concerning the effects of DFD on G6PD deficient red cells of the A- and B- variants were completed during the course of this contract. DFD is especially hemolytic even at low single dosages for G6PD deficient red cells of the B- type. The inve...

Compared behavior of 52 Costa Rican 12- to 23-month-olds with iron-deficiency anemia to that of 139 infants with better iron status. Found that iron-deficient infants maintained closer contact with caregivers; showed less pleasure and playfulness; were more wary, hesitant, and easily tired; made fewer attempts at test items; and ...

Ghrelin is produced predominantly in stomach and is known to be the endogenous ligand of the growth hormone secretagogue receptor (GHSR). Ghrelin is a GH stimulator and an orexigenic hormone. In contrast, leptin is an anorexic hormone, and leptin-deficient ob/ob mice are obese and diabetic. To study...

This article investigates calcium deficiency symptoms of the plants grown under hydroponics conditions. Leaf reflectance data were collected from plants, and then transformed to L*, a*, b* values, which provide color information of the leaves. After comparing the color information of deficient plants to control plants, a set of ...

The effect of vitamin E and/or selenium deficiency on the kinetics of erythrocyte production and destruction has been investigated in swine. The plasma iron turnover rate, 59Fe incorporation into newly formed red cells as well as the 51Cr apparent red cell half-life, were not found to be significantly affected by either vitamin E deficiency, selenium ...

The nutritional status of 80 patients with non-alcoholic chronic liver disease was assessed by determination of various nutritional parameters in body fluids. With the exception of vitamin C there was a higher incidence (40%) of fat soluble vitamin deficiency (vitamins A, E, and carotene) than of the water soluble vitamins. Less than 10% of patients showed evidence of vitamin ...

Connecticut Broadleaf tobacco was grown in the greenhouse at about 25/sup 0/C. Loss of elements from solution, nitrogen fractions and ascorbic acid in the leaf, and burn of cured leaf were determined for deficiencies of Fe, Zn, Cu, Mn, B and Mo. Micronutrient deficiency, except copper, led to an increased content in the leaf of nitrate and free amino acids ...

Cellular X-chromosome mosaicism, which is unique to females, may be advantageous during pathophysiological challenges compared with the single X-chromosome machinery of males, and it may contribute to gender dimorphism in the inflammatory response. We tested the hypothesis of whether cellular mosaicism for the X-linked gp91phox (NOX2) deficiency, the ...

Dietary fructose, when compared to cornstarch, exacerbates copper deficiency. The purpose of this study was to determine whether Zn deficiency is similarly enhanced by high fructose intake. Seventy-five male SD rats were randomly assigned to one of the following diets containing 62% of the indicated carbohydrate: Zn ...

Since pregnant rats consuming fructose, copper deficient diets fail to give birth, the relationship between maternal copper deficiency, polyol metabolism and fetal mortality was investigated. Forty Sprague-Dawley rats were fed from conception one of the following diets: fructose, copper deficient; fructose, copper adequate; starch, ...

Selenium deficiency is associated with impaired bone metabolism and osteopenia in rats. However, it is not known how combined selenium and iodine deficiency affects bone metabolism. Therefore, we investigated the effect of selenium and iodine deficiency on bone metabolism in 2nd-generation selenium- and ...

The hippocampus is especially sensitive to the effects of gestational and neonatal iron deficiency, even after iron repletion. This study compared the effects of iron deficiency, maintained from gestational day 2 to postnatal day (P)7, on �delay� and �trace� fear conditioning. Only the latter paradigm is critically dependent on ...

Cu deficiency results in altered levels of catecholamines in peripheral tissues and specific regions of the CNS in rodents. Because catecholamines can affect feeding behavior, meal patterns of control and Cu deficient rats were compared using a computerized system. Cu deficiency was induced by feeding dams a low Cu ...

AIMS--To examine the possibility that monocyte esterase deficiency (MED) could be caused by exposure to organophosphates. METHODS--Pseudocholinesterase, paraoxonase and arylesterase activities were measured in the serum and acetylcholinesterase activity was measured in the red cells of a group of monocyte esterase deficient subjects and ...

Pigs which were deficient in vitamin E and/or selenium had the following parameters weekly determined from six to 13 weeks of age: Packed cell volume, hemoglobin concentration, red cell and white cell counts, red cell indices, reticulocyte count, serum iron, serum total iron binding capacity, myeloid: erythroid ratio, serum glutamic-oxaloacetic transaminase and creatine ...

ObjectiveTo characterize the in vivo role epiphycan (Epn) has in cartilage development and/or maintenance.MethodsEpn-deficient mice were generated by disrupting the Epn gene in mouse embryonic stem cells. Epn/biglycan (Bgn) double-deficient mice were produced by crossing Epn-deficient mice with Bgn-deficient mice. ...

alpha 1-Antitrypsin (AAT) deficiency, also known as alpha 1-antiprotease inhibitor deficiency, is a disease caused by genetically determined AAT deficiency. It occurs as a result of inheritance of two protease inhibitor (PI) deficiency alleles from the AAT gene locus (designated PI) on chromosomal segment 14q32.1. ...

pyruvate and fumarate increased the O/sub 2/-uptake compared with an irradiated control. Pyruvate was inclined to complete the free radical as an easily oxidizable substance comparable with cystine. Fumarate was considered to supply the deficiency induced by x irradiation. (auth)

An applied research program was sponsored by the Department of Energy to analyze and compare the results from inspections that utilized infrared sensing systems to identify thermal deficiencies in buildings. This research consisted of both the laboratory ...

A sensitive in vitro method has been set up which measures the stimulation of the hexose monophosphate shunt (HMS) in normal and glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells. It has been used to measure and compare the stimulation pr...

In order to investigate the relationship between problems in behavioral control and children's capacity to utilize mediational strategies for self control, the responses of a group of disruptive (N=20) and nondisruptive (N=20) kindergarten children were compared in their approach to delay of gratification tasks. Subjects were compared on three forms of ...

The objective of this study is to examine if free radicals can be trapped in vivo in dietary Zn deficient rats using ESR spin trapping techniques. The ability of Zn deficient rats to cope with oxidative stress is also assessed. {alpha}-Phenyl-N-t-butyl-nitrone (PBN), a spin trap, was i.p injected at a dose of 75 mg or 150 mg/kg body weight. The tissue ...

This study was designed to determine the effect of selenium (Se) deficiency on the immune response to infection with a virulent strain of influenza virus, influenza A/Puerto Rico/8/34. Previous work in our laboratory demonstrated that Se-deficient mice infected with a mild strain of influenza virus, influenza A/ Bangkok/1/79, developed much more severe ...

The effects of growth in male Wistar rats and female Swiss Random mice were studied during dietary zinc (Zn) deficiency, copper (Cu) deficiency, and during the feeding of a histidine (His) supplement Growth was analyzed by comparing the characteristics of the decreasing exponential growth curve plotted for the experimental period. When ...

Circadian clock is implicated in the regulation of aging. The transcription factor CLOCK, a core component of the circadian system, operates in complex with another circadian clock protein BMAL1. Recently it was demonstrated that BMAL1 deficiency results in premature aging in mice. Here we investigate the aging of mice deficient for CLOCK protein. ...

Circadian clock is implicated in the regulation of aging. The transcription factor CLOCK, a core component of the circadian system, operates in complex with another circadian clock protein BMAL1. Recently it was demonstrated that BMAL1 deficiency results in premature aging in mice. Here we investigate the aging of mice deficient for CLOCK protein. ...

Copper deficiency adversely affects the extracellular matrix of the arterial wall, leading to cardiovascular lesions. To study the lesions resulting from copper deficiency, the composition of proteoglycans from aortas of copper-deficient rats was compared with proteoglycans of aortas from copper-supplemented rats. ...

BackgroundClinical association studies have yielded varied results regarding the impact of glucose-6-phosphate dehydrogenase (G6PD) deficiency upon susceptibility to malaria. Analyses have been complicated by varied methods used to diagnose G6PD deficiency.Methodology/Prinicipal FindingsWe compared the association between uncomplicated ...

The pathogenesis of zinc deficiency and its relationship to hypogeusia were studied in three chronic dialysis units in Toronto. The difference between low plasma zinc levels at two of the hospitals compared to the normal levels in the third hospital was significantly related to levels of dietary zinc intake which in turn was due to the levels of dietary ...

A survey of the incidence of monocyte esterase deficiency in 4000 inpatients (including 808 with malignant neoplastic disease) and 474 normal controls was performed using an automated esterase method. A highly significant excess of patients with malignant disease and the deficiency was evident when compared with normal controls or all ...

Calcium (Ca) uptake was markedly increased in ATP-depleted red cells of patients with iron deficiency anemia (IDA) compared to ATP- depleted normal red cells. The extent of increased Ca uptake was related to the severity of iron deficiency as judged by decreased mean cell volume. Moreover, the increased Ca uptake returned to normal ...

Canavan disease (CD) is a neurodegenerative disease, caused by a deficiency in the enzyme aspartoacylase (ASPA). This enzyme has been localized to oligodendrocytes; however, it is still undefined how ASPA deficiency affects oligodendrocyte development. In normal mice the pattern of ASPA expression coincides with oligodendrocyte maturation. Therefore, ...