In pursuit of an improved understanding and treatment of Parkinson's disease (PD) and related neuropsychiatric disease we have held a translational research conference entitled, 'Targeting Adenosine A2A Receptors in Parkinson's Disease and other CNS Disor...
National Technical Information Service (NTIS)
... modify the affinity for the hormone or ligand ... intake, suggesting that female hormones may prevent the ... that treatment with A2A antagonists may be a ...
DTIC Science & Technology
... PARKINSONS DISEASE, SYMPOSIA, ADENOSINE, STROKES(CEREBRAL), CLINICAL TRIALS, ALZHEIMER DISEASE, MENTAL DISORDERS ...
Adenosine regulates the function of the innate and adaptive immune systems through targeting virtually every cell type that is involved in orchestrating an immune/inflammatory response. Of the four adenosine receptors (A(1), A(2A), A(2B), A(3)), ...
PubMed
Huntington disease (HD) is a neurodegenerative disorder involving preferential loss of striatal GABAergic medium spiny neurons. Adenosine A(2A) receptors (A(2A)Rs) are present in the striatum at both presynaptic and post-synaptic levels. Blocking pre-synaptic ...
Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that result from degeneration of the dopaminergic input to the striatum and chronic inhibition of striatal dopamine D(2) receptors by antipsychotics, respectively. Adenosine A(2A) receptors are selectively localized in the basal ...
A(2A) adenosine receptors are considered an excellent target for drug development in several neurological and psychiatric disorders. It is noteworthy that the responses evoked by A(2A) adenosine receptors are regulated by D(2) dopamine receptor ligands. These two ...
Adenosine receptors are G protein-coupled receptors (GPCRs) that mediate the physiological functions of adenosine. In the central nervous system adenosine A2A receptors (A2ARs) are highly enriched in striatopallidal neurons where they form functional ...
