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1
Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak.
2009-10-27

Chikungunya has resurged in the form of unprecedented explosive epidemic in 2006 after a long gap in India affecting 1.39 million of persons. The disease continued for the next two consecutive years affecting 59,535 and 64,548 persons during 2007 and 2008 respectively. The 2008 outbreak being the second largest among these three years the information regarding the etiology and ...

PubMed

2
Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak
2009-10-27

Chikungunya has resurged in the form of unprecedented explosive epidemic in 2006 after a long gap in India affecting 1.39 million of persons. The disease continued for the next two consecutive years affecting 59,535 and 64,548 persons during 2007 and 2008 respectively. The 2008 outbreak being the second largest among these three years the information regarding the etiology and ...

PubMed Central

3
Molecular characterization of Chikungunya virus isolates from clinical samples and adult Aedes albopictus mosquitoes emerged from larvae from Kerala, South India
2010-08-13

Chikungunya virus (CHIKV), an arthritogenic alphavirus, is transmitted to humans by infected Aedes (Ae.) aegypti and Ae.albopictus mosquitoes. In the study, reverse-transcription PCR (RT PCR) and virus isolation detected CHIKV in patient samples and also in adult Ae.albopictus mosquitoes that was derived from larvae collected during a chikungunya (CHIK) ...

PubMed Central

4
A Single Mutation in Chikungunya Virus Affects Vector Specificity and Epidemic Potential
2007-12-07

Chikungunya virus (CHIKV) is an emerging arbovirus associated with several recent large-scale epidemics. The 2005�2006 epidemic on Reunion island that resulted in approximately 266,000 human cases was associated with a strain of CHIKV with a mutation in the envelope protein gene (E1-A226V). To test the hypothesis ...

PubMed Central

5
Chikungunya virus adaptation to Aedes albopictus mosquitoes does not correlate with acquisition of cholesterol dependence or decreased pH threshold for fusion reaction
2011-07-29

BackgroundChikungunya virus (CHIKV) is a mosquito transmitted alphavirus that recently caused several large scale outbreaks/epidemics of arthritic disease in tropics of Africa, Indian Ocean basin and South-East Asia. This re-emergence event was facilitated by genetic adaptation (E1-A226V substitution) of CHIKV to a ...

PubMed Central

6
Characterization of Chikungunya pseudotyped viruses: Identification of refractory cell lines and demonstration of cellular tropism differences mediated by mutations in E1 glycoprotein
2009-08-18

Chikungunya virus (CHIKV) is an alphavirus responsible for a number of large outbreaks. Here we describe the efficient incorporation of CHIKV envelope glycoproteins into lentiviral and rhabdoviral particles. Vectors pseudotyped with CHIKV envelope proteins efficiently transduced many cell types from different species. However, hematopoietic cell types were either partially or ...

PubMed Central

7
Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak
2006-07-23

BackgroundA chikungunya virus outbreak of unprecedented magnitude is currently ongoing in Indian Ocean territories. In R�union Island, this alphavirus has already infected about one-third of the human population. The main clinical symptom of the disease is a painful and invalidating poly-arthralgia. Besides the arthralgic form, 123 patients with a confirmed ...

PubMed Central

8
Re-emergence of Chikungunya virus in South-east Asia: virological evidence from Sri Lanka and Singapore.
2009-12-02

Chikungunya fever swept across many South and South-east Asian countries, following extensive outbreaks in the Indian Ocean Islands in 2005. However, molecular epidemiological data to explain the recent spread and evolution of Chikungunya virus (CHIKV) in the Asian region are still limited. This study describes the genetic Characteristics and evolutionary ...

PubMed

9
Chikungunya virus adaptation to Aedes albopictus mosquitoes does not correlate with acquisition of cholesterol dependence or decreased pH threshold for fusion reaction.
2011-07-29

ABSTRACT: BACKGROUND: chikungunya virus (CHIKV) is a mosquito transmitted alphavirus that recently caused several large scale outbreaks/epidemics of arthritic disease in tropics of Africa, Indian Ocean basin and South-East Asia. This re-emergence event was facilitated by genetic adaptation (E1-A226V substitution) ...

PubMed

10
Two Chikungunya Isolates from the Outbreak of La Reunion (Indian Ocean) Exhibit Different Patterns of Infection in the Mosquito, Aedes albopictus
2007-11-14

BackgroundA Chikungunya (CHIK) outbreak hit La R�union Island in 2005�2006. The implicated vector was Aedes albopictus. Here, we present the first study on the susceptibility of Ae. albopictus populations to sympatric CHIKV isolates from La R�union Island and compare it to other virus/vector combinations.Methodology and FindingsWe orally infected 8 Ae. albopictus ...

PubMed Central

11
Clinical and virological characterization of imported cases of Chikungunya fever.
2008-01-01

A Chikungunya virus (CHIKV) epidemic emerged in the Indian Ocean islands of the Comores, Reunion, Mayotte, Mauritius, the Seychelles and Madagascar in 2005 resulting in the infection of about 250.000 inhabitants and travellers in only one year. Beginning in March 2006 increasing numbers of CHIKV-like febrile illnesses were reported from various parts of India. We investigated ...

PubMed

12
Role of Gregarine Parasite Ascogregarina culicis (Apicomplexa: Lecudinidae) in the Maintenance of Chikungunya Virus in ...

... These mosquito species are also known to transmit dengue and Chikungunya viruses. The sporozoites of these parasites ... of these gregarines in the vertical transmission of dengue and Chikungunya viruses ...

NBII National Biological Information Infrastructure

13
Development of an Attenuated Strain of Chikungunya Virus for ...
1986-09-01

... Accession Number : ADA176204. Title : Development of an Attenuated Strain of Chikungunya Virus for Use in Vaccine Production,. ...

DTIC Science & Technology

14
Concentration of Rift Valley Fever and Chikungunya Viruses ...
1970-04-01

... VALLEY FEVER VIRUS, CHIKUNGUNYA VIRUS, BLOOD SERUM, VIRUSES, CONCENTRATION(CHEMISTRY), POTASSIUM COMPOUNDS. ...

DTIC Science & Technology

15
Assay of Chikungunya Virus in Cell Monolayers by ...
1969-12-01

... Abstract : Chikungunya virus was assayed quantitatively by ... The immunofluorescent assay was comparable in ... rapid than virus assays based ...

DTIC Science & Technology

16
In vitro antiviral activity of arbidol against Chikungunya virus and characteristics of a selected resistant mutant.
2011-04-01

Arbidol (ARB) is an antiviral drug originally licensed in Russia for use against influenza and other respiratory viral infections. Although a broad-spectrum antiviral activity has been reported for this drug, there is until now no data regarding its effects against alphavirus infection. Here, the in vitro antiviral effect of ARB on Chikungunya virus (CHIKV) replication was ...

PubMed

17
Outbreak of Chikungunya in the Republic of Congo and the global picture.
2011-07-04

Chikungunya fever is a crippling disease caused by an arthropod-borne virus (arbovirus) transmitted to humans through mosquitoes. Although Chikungunya virus is not often associated with mortality, the effects of virus outbreaks are often devastating, causing significant economic loss due to the strain on health care. Chikungunya is ...

PubMed

18
Chikungunya in Southeast Asia: understanding the emergence and finding solutions.
2011-07-18

In the last few years, chikungunya has become a major problem in Southeast Asia, with large numbers of cases being reported in Singapore, Malaysia, and Thailand. Much of the current epidemic of chikungunya in Southeast Asia is being driven by the emergence of a strain of chikungunya virus that originated in Africa and spread to islands ...

PubMed

19
Fact Sheet | CDC Chikungunya
2011-08-21

Humans become infected with chikungunya virus by the bite of an infected mosquito. Aedes aegypti, a household container breeder and aggressive daytime biter which is attracted...

Science.gov Websites

20
Genetic predisposition to chikungunya � a blood group study in chikungunya affected families
2009-06-16

Chikungunya fever is a viral disease transmitted to humans by the bite of CHIKV virus infected Aedes mosquitoes. During monsoon outbreak of chikungunya fever, we carried out the genetic predisposition to chikungunya in disease affected 100 families by doing blood group (ABO) tests by focusing on individuals who were likely to have a ...

PubMed Central

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21
Aedes albopictus Mosquito: The Main Vector of the 2007 Chikungunya Outbreak in Gabon
2009-03-04

The primary vector at the origin of the 2007 outbreak in Libreville, Gabon is identified as Aedes albopictus, trapped around the nearby French military camp. The Chikungunya virus was isolated from mosquitoes and found to be identical to the A226V circulating human strain. This is the first field study showing the role of the recently arrived species Aedes albopictus in ...

PubMed Central

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