Highly attenuated modified vaccinia virus Ankara (MVA) is being considered as a safer alternative to conventional smallpox vaccines such as Dryvax or ACAM 2000, but it requires higher doses or more-frequent boosting than replication-competent Dryvax. Previously, we found that passive transfer of A27 antibodies can enhance protection afforded by vaccinia immune globulin (VIG), which is derived from ...
PubMed
... growth factor receptor in a murine T-cell hybridoma: a transmembrane protein Pyrosine kinase can synergize with the T-cell antigen receptor *~. ...
DTIC Science & Technology
... Factor Receptor in a Murine T- Cell Hybridoma: A Transmembrane Protein Tyrosine Kinase Can Synergize with the T-Cell Antigen Receptor. ...
In plants, viral synergisms occur when one virus enhances infection by a distinct or unrelated virus. Such synergisms may be unidirectional or mutualistic but, in either case, synergism implies that protein(s) from one virus can enhance infection by another. A mechanistically related phenomenon is ...
Bioassays of insecticidal proteins from Bacillus thuringiensis subsp. israelensis with larvae of the malaria vector mosquito Anopheles albimanus showed that the cytolytic protein Cyt1Aa was not toxic alone, but it increased the toxicity of the crystalline proteins Cry4Ba and Cry11Aa. Synergism also occurred between ...
Current systemic therapies have little curative benefit for synovial sarcoma. Histone deacetylase (HDAC) inhibitors and the heat shock protein 90 (Hsp90) inhibitor 17-AAG have recently been shown to inhibit synovial sarcoma in preclinical models. We tested combinations of 17-AAG with the HDAC inhibitor MS-275 for synergism by proliferation and apoptosis ...
PubMed Central
Propolis is a natural resinous substance collected by bees from tree exudates and secretions. Its antimicrobial activity has been investigated and inhibitory action on Staphylococcus aureus growth was evaluated. The in vitro synergism between ethanolic extract of propolis (EEP) and antimicrobial drugs by two susceptibility tests (Kirby and Bauer and E-Test) on 25 S. aureus ...
Synergism, evolution, and functional ecogenomics of deep-subsurface microbial ... This synergism may contribute to microbial biosustainability in ...
NASA Website
... Title : Additivity, synergism, and antagonism in flame retardancy,. ... The concepts of additivity, synergism, and antagonism will be reviewed. (TSJ). ...
By using human CD4+ lymphoblastoid T cells transiently cotransfected with human immunodeficiency virus (HIV) and cytomegalovirus (CMV), we tested whether modulation of T-cell activation through the protein kinase C (PKC) or the protein kinase A (PKA) pathway synergized with CMV immediate-early (IE) proteins in HIV ...
SummaryBackgroundReceptors that couple to Gi and Gq often interact synergistically in cells to elicit cytosolic Ca2+ transients that are several-fold higher than the sum of those driven by each receptor alone. Such synergism is commonly assumed to be complex, requiring regulatory interaction between ...
Bacillus thuringiensis subsp. israelensis (Bti) produces at least four different crystal proteins that are specifically toxic to different mosquito species and that belong to two non-related family of toxins, Cry and Cyt named Cry4Aa, Cry4Ba, Cry11Aa and Cyt1Aa. Cyt1Aa enhances the activity of Cry4Aa, Cry4Ba or Cry11Aa and overcomes resistance of Culex quinquefasciatus ...
... Justification SYNERGISM OF MECHANICS, MATHEMATICS AND BY ..... ANISOTROPIC ELASTIC MA ERIALS Distribution / ...
... Title : Synergism of Influence of Monoethanolamine and Ammonium Pentaborate on Corrosion and Corrosion Fatigue of ST3,. ...
... Title : Synergism between Penicillin, Clindamycin, or Metronidazole and Gentamicin against Species of the Bacteroides melaninogenicus and ...
... Accession Number : ADD458175. Title : SYNERGISM OF MICROSTRUCTURE, MECHANISMS AND MECHANICS IN FRACTURE. ...
... Title : SYNERGISM OF ANTIOXIDANTS IN SYNTHETIC ESSENTIAL OIL (SINERGIZME ANTIOKSIDANTOV V SINTETICHESKOM EFIRNOM ...
... In combination with a neural signal, however, PKC demonstrates a profound synergism. Synergism is also observed in ...
... Title : PLANNING BY MAN-MACHINE SYNERGISM: A CHARACTERIZATION OF PROCESSES AND ENVIRONMENT,. ...
... Title : ON THE SYNERGISM OF THE CHOLINESTERASE-REACTIVATING BISPYRIDINIUM ALDOXIME HI-6 AND ATROPINE IN THE ...
... Title : Mechanism of the Effect of Synergism in Process of the Burning of Hydrogen with the Additions of Diethylamine and Tetrafluorodibromoethane ...
... Accession Number : ADD114459. Title : ENVIRONMENTAL SYNERGISM AND SIMULATION IN RESIN MATRIX COMPOSITES,. ...
Some orthopoxviruses, e.g., the cowpox, ectromelia, and raccoonpox viruses, form large, discrete cytoplasmic inclusions within which mature virions (MVs) are embedded by a process called occlusion. These inclusions, which may protect occluded MVs in the environment, are composed of aggregates of the A-type inclusion protein (ATIp), which is truncated in orthopoxviruses such as ...
HC-Pro, a well-characterized multi-functional protein encoded by members of the genus Potyvirus, has been shown to be involved in aphid transmission, replication maintenance, systemic movement, and posttranscriptional gene silencing (PTGS) suppression, and to be a determinant of disease synergism in...
Technology Transfer Automated Retrieval System (TEKTRAN)
14) is a Gram-positive bacterium that forms parasporal crystal proteins (d-endotoxins) during). The d-endotoxin proteins differ, qualitatively and quan- titatively, in their toxicity levels tandem lacO operators. Mosquito-larvicidal E. coli-expressing d-endotoxin genes 799 Q 2001 Blackwell
E-print Network
and Bacillus subtilis mutants which lack the protease that degrades small, acid-soluble proteins during spore of Ger proteins in nutrient and nonnutrient triggering of spore germination in Bacillus subtilis. J) Cooperativity between different nutrient receptors in germination of spores of Bacillus subtilis and reduction
The template and coactivator requirements for synergistic transcription directed by a single activator, Bicoid (BCD), bound to multiple sites have been determined. Mutagenesis studies in combination with protein binding experiments and reconstituted transcription reactions identified two independent activation domains of BCD that target different coactivator subunits (TAFII110 ...
Mitochondrial uncoupling proteins are a proton transporter family involved in regulation mitochondrial superoxide and ATP production. Uncoupling proteins are expressed by rat spiral ganglion and vestibular ganglion cells [Hear Res 196 (2004) 39]. This study tests the hypothesis that uncoupling protein expression is up-regulated in ...
Coordinate activation of transcription by multiple enhancer binding factors is essential for the regulation of pattern formation during development of Drosophila melanogaster. Cell-free transcription reactions are described that recapitulate transcriptional synergism directed by the Drosophila developmental regulators Bicoid (BCD) and Hunchback (HB). Within the basal ...
Therapeutic proteins such as monoclonal antibodies, replacement enzymes and toxins have significantly improved the therapeutic options for multiple diseases, including cancer and inflammatory diseases as well as enzyme deficiencies and inborn errors of metabolism. However, immune responses to these products are frequent and can seriously impact their safety and efficacy. Of ...
Page 1. Synergizing Logistics Training and Education EWS 2005 ... 4. TITLE AND SUBTITLE Synergizing Logistics Training and Education 5a. ...
Several protein domains acting through seemingly different mechanisms have been reported to have the capacity to target proteins to dense core secretory granules. Because proteins enter secretory granules with different efficiencies and because some of these proteins contain more than one granule-targeting motif, ...
Stimulation of the phosphatidylinositol cycle by neurotransmitters generates diacylglycerol, an activator of protein kinase C, which may regulate some forms of neurotransmission. Phorbol esters, potent inflammatory and tumorpromoting compounds, also activate protein kinase C. We demonstrate potent and selective effects of phorbol esters on smooth muscle, ...
NASA Astrophysics Data System (ADS)
Immunization with recombinant proteins may provide a safer alternative to live vaccinia virus for prophylaxis of poxvirus infections. Although antibody protects against vaccinia virus infection, the mechanism is not understood and the selection of immunogens is daunting as there are dozens of surface proteins and two infectious forms known as the mature ...
After being ingested by target insects, the insecticidal proteins from Bacillus thuringiensis (Bt) need to go through a proteolytic process by insect midgut proteinases to become activated. At the same time, Bt can be hydrolyzed and degraded by midgut proteinases to become non-toxic to target insect...
Induced osteogenesis includes a program of microRNAs (miRs) to repress the translation of genes that act as inhibitors of bone formation. How expression of bone-related miRs is regulated remains a compelling question. Here we report that Runx2, a transcription factor essential for osteoblastogenesis, negatively regulates expression of the miR cluster ...
Sweet potato (Ipomoea batatas) is an important subsistence and famine reserve crop grown in developing countries where Sweet potato chlorotic stunt virus (SPCSV; Closteroviridae), a single-stranded RNA (ssRNA) crinivirus, synergizes unrelated viruses in co-infected sweet potato plants. The most severe disease and yield losses are caused by co-infection with SPCSV and a ...
Hydrolysis of microcrystalline cellulose (Avicel) by cellobiohydrolase I and II (CBH I and II) from Trichoderma reesei has been studied. Adsorption and synergism of the enzymes were investigated. Experiments were performed at different temperatures and enzyme/substrate ratios using CBH I and CBH II alone and in reconstituted equimolar mixtures. Fast ...
Energy Citations Database
Arginine kinase (AK) is a key enzyme for cellular energy metabolism, catalyzing the reversible phosphoryl transfer from phosphoarginine to ADP in invertebrates. In this study, the inter-subunit hydrogen bonds between the Q53 and D200 and between D57 and D200 were disrupted to explore their roles in the activity and structural stability of Stichopus japonicus (S. japonicus) AK. Mutating Q53 and/or ...
Using conventional and scanning transmission electron microscopy, the authors have examined the physical basis of long-range enhancer effects between distal and proximal elements in a eukaryotic promoter. Specifically, they studied binding of human transcription factor Sp1 to 10-base-pair G + C-rich elements (GC boxes) located at {minus}100 and +1700 relative to the RNA start site. It was ...
