Histone deacetylation and DNA methylation have a central role in the control of gene expression in tumours, including transcriptional repression of tumour suppressor genes and genes involved in sensitivity to chemotherapy. Treatment of cisplatin-resistant cell lines with an inhibitor of DNA methyltransferases, 2-deoxy-5'azacytidine (decitabine), results in partial reversal of DNA methylation, ...

Histone deacetylation and DNA methylation have a central role in the control of gene expression in tumours, including transcriptional repression of tumour suppressor genes and genes involved in sensitivity to chemotherapy. Treatment of cisplatin-resistant cell lines with an inhibitor of DNA methyltransferases, 2-deoxy-5?azacytidine (decitabine), results in partial reversal of DNA methylation, ...

BackgroundWe recently demonstrated that increased expression of the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in epithelial ovarian cancer (EOC) and the cisplatin response upon RBM3 depletion in a cisplatin-sensitive ...

ABSTRACT: BACKGROUND: Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive cancers in women. Advanced stage diagnosis and chemo/radio-resistance is a major obstacle in treating advanced ...

... localization of steroidogenic enzymes in human follicle following xenotransplantation of the human ovarian cortex into NOD-SCID ... ...

... in women with a family history of ovarian ... OVARIAN CANCER, HISTORY, WOMEN, PERSONALITY, GENETICS, FAMILIES(HUMAN ...

... The rhesus macaque could serve as an excellent model for the study of chemoprevention of ovarian cancer. These monkeys are close to humans ...

... TITLE: Aurora-A Oncogene in Human Ovarian Cancer ... 4. TITLE AND SUBTITLE Aurora-A Oncogene in Human Ovarian Cancer 5a. ...

... Title : Cell Growth and Survival in Ovarian Epithelial Cancer Project 1: AKT2 Oncogene and Its Associated Protein APBP in Human Ovarian Cancer. ...

Ovarian cancer is the fourth leading cause of cancer-related death in U.S. women. This program project approaches the ovarian cancer problem by 1) establishing a human ovarian tissue and clinical data base core facility to support the proposed projects an...

Ovarian cancer is the fourth leading cause of cancer-related death in U.S. women. This program project approaches the ovarian cancer problem by (1) establishing a human ovarian tissue and clinical data base core facility to support the proposed projects a...

Ovarian cancer is the fourth leading cause of cancer-related death in U.S. women. This program project approaches the ovarian cancer problem by 1) establishing a human ovarian tissue and clinical data base core facility to support the proposed projects an...

Ovarian cancer is the fourth leading cause of cancer-related death in U.S. women. This program project approaches the ovarian cancer problem by (1) establishing a human ovarian tissue and clinical data base core facility to support the proposed projects a...

The goal of this project is to elucidate some of the genetic and biological determinants of ovarian cancer, focusing on an in vitro model for ovarian cancer that we have developed. We found that immortalization and transformation of human ovarian surface ...

The goal of this project is to elucidate some of the genetic and biological determinants of ovarian cancer, focusing on an in vitro model for ovarian cancer that we have developed. We found that immortalization and transformation of human ovarian surface ...

... the University of California, San Francisco. The normal human tissues were collected from salpingo-oophorectomy specimens removed for ... and EGFR protein expression in human tumor ovarian tissue. Human o...

... of this project is that the hen is an excellent model for human ovarian epithelial cell ... of hens because we were not able to obtain 2-year old hens at ...

... Title : Aurora-A Oncogene in Human Ovarian Cancer. ... Aurora-A inhibits cytochrome C release and Bax conformational change induced by CDDP. ...

... FIBROBLASTS, HYPOTHESES, PATHOLOGY, CHICKENS, CELLS(BIOLOGY), TRANSFORMATIONS, PROGESTERONE, OVARIES, OVULATION. ...

... of both of these genes in the development of this type of ovarian cancer we hypothesize that inactivation of BRCA1 and p53in the ovaries of mice ...

... of both of these genes in the development of this type of ovarian cancer, we hypothesize that inactivation of BRCA1 and p53 in the ovaries of mice ...

... in women with a family history of ovarian ... CROSS SECTIONS, HISTORY, INDEXES, WOMEN ... GENETICS, FEMALES, FAMILIES(HUMAN), ANXIETY. ...

... cell death is an essential process for the homeostasis of ovarian function in human and other mammalian species. This process has been ... ...

... difference between the two strains that could underlie the differential susceptibility to ovarian cancer We have accumulated many hens of both ...

... women with germ cell tumors, blood tests for alpha-fetoprotein (AFP) and/or human chorionic gonadotropin (HCG) ... Ovarian Cancer? Causes, Risk Factors, and Prevention Early Detection, Diagnosis, and Staging Treating Ovarian Cancer Talking With ...

... Title : Genetic Definition and Phenotype Determinants of Human Ovarian Carcinomas. ... to establish its ability to mediate recombination in mouse ...

... development of human ovarian follicle: A study by high-resolution scanning and transmission electron microscopy. Arch. Histol. Cytol., ... ...