Patients with Alport syndrome progressively lose renal function as a result of defective type IV collagen in their glomerular basement membrane. In mice lacking the ?3 chain of type IV collagen (Col4A3 knockout mice), a model for Alport syndrome, transplantation of wild-type bone marrow repairs ...
PubMed Central
Homepage Trans-NIH Mouse Initiatives Overweight Mice Deltagen and Lexicon Knockout Mice and Phenotypic Data * The Resource * Fact Sheet * List of Available Knockout Mice *...
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Prior studies demonstrate that adenosine, acting at one or more of its receptors, mediates the anti-inflammatory effects of methotrexate in animal models of both acute and chronic inflammation. Both adenosine A2A and A3 receptors contribute to the anti-inflammatory effects of methotrexate treatment in the air pouch model of inflammation, and the regulation of inflammation by these two receptors ...
PubMed
The role of A3 adenosine receptors (ARs) in sepsis and inflammation is controversial. In this study, we determined the effects of A3AR modulation on mortality and hepatic and renal dysfunction in a murine model of sepsis. To induce sepsis, congenic A3AR knockout mice (A3AR ...
This method uses homologous recombination to disable a gene of interest to produce a genetic knockout.
NSDL National Science Digital Library
BACKGROUND:: Pharmacological studies suggest that adenosine A(3)AR influences motility and colitis. Functional A(3) (-/-)AR knockout mice were used to prove whether A(3)AR activation is involved in modulating either motility or ...
... Crossing the homozygous floxed ER-alpha mice with WAP-cre mice is expected to conditionally knockout ER-alpha in lactating mice, allowing us to ...
DTIC Science & Technology
Previous reports have indicated that adenosine A3 receptor (A3R) knockout mice are more sensitive to ischemic or hypoxic brain injury. The purpose of this study was to examine if suppression of A3R expression is associated with increase in sensitivity to injury induced by a ...
... the maintenance of pregnancy [26, 27]. Female PRLR knockout mice are sterile, due to a failure of implantation [28]. Generation of viable PRL knockout and PRLR knockout mice also suggests that embryo-uteri...
NBII National Biological Information Infrastructure
Laminar Specificity of Local Circuits in Barrel Cortex of Ephrin-A5 Knockout Mice N. Harumi Yabuta arbors in ephrin-A5 knockout mice. We find that in barrel cortex of knockout mice, layer 2/3 pyramidal neurons in S1 barrel cortex of ephrin-A5 knockout ...
E-print Network
... AR knockout prostate cancer cell lines. The effect of AR loss in these cells will be examined for ability to generate/promote tumors in mice. ...
Compare SAP102 knockout mice and wild-type mice on a task designed to measure spatial learning and memory.
... Localization of Sarcocystis neurona in Interferon Gamma Gene Knockout Mice Fed SporocystsJ. P. DubeyU.S. Department of Agriculture, ... of Sarcocystis neurona in tissues of interferon gamma knockout mice ...
... SP Receptor Circuitry in the Substance P-Precursor Knockout Mice or SP Receptor, Neurokinin (NK)1 Knockout Mice Leads to an Inhibited Cytokine Response in Granulomas ... ...
Alport syndrome is a hereditary nephropathy that results in irreversible, progressive renal failure. Recent reports suggested that bone marrow transplantation (BMT) has a beneficial, short-term effect on renal injury in Alport (Col4a3?/?) mice, but its long-term effects, especially with regard to survival, are ...
... Accession Number : ADA433808. Title : The Use of Gene Knockout Mice in Thermoregulation Studies. Descriptive Note : Journal article. ...
... Double KO mice were obtained in our laboratory by intercross of single knockout mice. Both single knockouts were backcrossed in our laboratory to ...
... component of reproductive physiology For example ER(3-knockout-mice have few reproductive deficits in contrast to ERa-knockout mice which are ...
Ghrelin knockout (GKO) and ghrelin receptor (growth hormone secretagogue receptor) knockout (GHSRKO) mice exhibit enhanced insulin sensitivity, but the mechanism is unclear. Insulin sensitivity declines with age and is inversely associated with accumulation of lipid in liver, a key glucoregulatory ...
Technology Transfer Automated Retrieval System (TEKTRAN)
Antidepressant drugs produce therapeutic actions and many of their side effects via blockade of the plasma membrane transporters for serotonin (SERT/SLC6A2), norepinephrine (NET/SLC6A1), and dopamine (DAT/SLC6A3). Many antidepressants block several of these transporters; some are more selective. Mouse gene knockouts of these ...
Antidepressant drugs produce therapeutic actions and many of their side effects via blockade of the plasma membrane transporters for serotonin (SERT/SLC6A2), norepinephrine (NET/SLC6A1) and dopamine (DAT/SLC6A3). Many antidepressants block several ofthese transporters; some are more selective. Mouse gene knockouts of these transporters ...
... Mammary tumorigenesis is further accelerated in p53-deficient Wnt-1 TG mice generated by mating Wnt-1 TG mice with p53-knockout mice. ...
Prenatal Lens Development in Connexin43 and Connexin50 Double Knockout Mice Thomas W. White,1-deficient mice has been previously described.12 For this study, F1 hybrid (129Sv x C57BL/6) Cx50-knockout animals were backcrossed for six genera- tions into the C57BL/6 genetic background. ...
... to address several aspects of the role of AR in the prostate that could not previously be addressed with Tfm mice or by treatment with antiandrogens ...
survival, female reproductive function, and maternal behavior. gene expression regulation knockout mice is apparent early in postnatal life, and fertility in the knockout mice is greatly reduced compared with wild in the oxytocin-deficient oxytocin knockout and Mf3 knockout ...
