The EphA4 tyrosine kinase cell surface receptor regulates an array of physiological processes and is the only currently known class A Eph receptor that binds both A and B class ephrins with high affinity. We have solved the crystal structure of the EphA4 ligand binding domain alone and in complex with (1) ephrinB2 and (2) ephrinA2. This set of structures shows that EphA4 has significant ...

Cell-free mammalian plasma transformed leukotriene A4 into leukotriene B4. This conversion originated from a soluble enzymatic activity. Heating at 56 degrees C or digestion of plasma with a proteolytic enzyme eliminated formation of leukotriene B4 but not other diastereomeric dihydroxyicosatetraenoic acids formed by nonenzymatic hydrolysis of leukotriene ...

ABS>A 4 pi counter was designed with a means for facilitating sample change and improved isolation from the atmosphere. The counter has an integral background of 2 to 3 imp/min and can be utilized for measuring very weak activities. (R.V.J.)

Regulatory T cells (Tregs) are thought to facilitate tumor development by suppressing protective antitumor immune responses. However, recent clinical and laboratory studies show that Tregs are a favorable element against cancer. In this study, we provide evidence that Tregs have both promoting and inhibiting effects on tumors, depending on the stage of tumor development. By ...

A survey of PDE4 inhibitors reveals that some compounds trigger intracellular aggregation of PDE4A4 into accretion foci through association with the ubiquitin-binding scaffold protein p62 (SQSTM1). We show that this effect is driven by inhibitor occupancy of the catalytic pocket and stabilization of a "capped state" in which a sequence within the enzyme's upstream conserved region 2 (UCR2) module ...

... by ex- ploiting cross-class data pooling ideas that originate in Fisher's work (see [141). Simultaneous PDF approximation ...

Cooperative learning exercises can be as simple as a five minute in class exercise or as complex as a project which crosses class periods. These can be described more generally in terms of low, medium, and high ...

Aryl hydrocarbon receptor (AhR) transcriptional activity is enhanced by interaction with p160 coactivators. We demonstrate here that NcoA4, a nuclear receptor coactivator, interacts with and amplifies AhR action. NcoA4-AhR and NcoA4-ARNT interactions were demonstrated by immunoprecipitation in T47D breast cancer and COS cells and was independent of ligand. ...

Cytochrome P450 3A4 (CYP3A4) is the most abundant CYP enzyme in the liver and metabolizes approximately 50% of the drugs, including antiretrovirals. Although CYP3A4 induction by ethanol and impact of CYP3A4 on drug metabolism and toxicity is known, ...

...initiating investigations of places of employment. 85a.4 Section 85a.4...HEALTH INVESTIGATIONS OF PLACES OF EMPLOYMENT § 85a.4 Procedures for initiating investigations of places of employment. (a) Except as...

...2009-04-01 false Procedure for requesting approval. 3a.4 Section 3a.4 Foreign Relations DEPARTMENT OF STATE GENERAL...FOREIGN GOVERNMENTS BY MEMBERS OF THE UNIFORMED SERVICES § 3a.4 Procedure for requesting approval....

... 2011-01-01 2011-01-01 false Investigator. 269a.4 Section 269a.4 Banks and...RESERVE SYSTEM DEFINITIONS § 269a.4 Investigator. The term investigator means the officer designated by the...

Exploratory holes UE25a-4, UE25a-5, UE25a-6, and UE25a-7 were drilled at the Nevada Test Site (NTS) to determine the suitability of pyroclastic deposits as storage sites for radioactive waste. Studies have been conducted to investigate the stratigraphy, structure, mineralogy, petrology, and physical properties of the tuff units encountered in the drill ...

Mutations in SLC26A4 can cause deafness and goiter in Pendred syndrome (PDS) or isolated non-syndromic enlargement of the vestibular aqueduct (NSEVA). PDS is one of the most common hereditary causes of deafness. It is characterized by autosomal-recessive inheritance of sensorineural hearing loss, enlarged vestibular aqueducts (EVA), and an iodide organification defect with or without goiter. The ...

We describe a novel fragment library termed fragments of life (FOL) for structure-based drug discovery. The FOL library includes natural small molecules of life, derivatives thereof, and biaryl protein architecture mimetics. The choice of fragments facilitates the interrogation of protein active sites, allosteric binding sites, and protein?protein interaction surfaces for ...

$vpn'Cl 002d &a+. 002d &a+. 002d &a+. 002d &a+. \\002d &a+. H002d &a+4 002d &a+4 002d &a+4 002d &a+4 002d &a+4 002d ...

In support of EPRI's interest in titanium alloy blading for low pressure steam turbines, the Technical University of Hamburg-Harburg has been studying the effects of microstructure and texture of the mechanical properties of a titanim alloy Tl-6A-4V that are important in the low pressure blade applications. These studies are presented in the form ...

This article identifies novel factors involved in cholesterol reduction by probiotic bacteria, which were identified using genetic and proteomic approaches. Approximately 600 Lactobacillus acidophilus A4 mutants were created by random mutagenesis. The cholesterol-reducing ability of each mutant was determined and verified using two different methods: the ...

This article identifies novel factors involved in cholesterol reduction by probiotic bacteria, which were identified using genetic and proteomic approaches. Approximately 600 Lactobacillus acidophilus A4 mutants were created by random mutagenesis. The cholesterol-reducing ability of each mutant was determined and verified using two different methods: the ...