A508 Gr 4N has improved fracture toughness because of the addition of 3% nickel, compared to typical low alloy steels which have less than 1% nickel. However, there is an expectation in much of the recent literature, based mostly on low-alloy steels with nickel below 1%, that irradiation ...
DOE Information Bridge
Neutron irradiation can promote significant changes in the microstructure and associated mechanical properties of low alloy steels. In particular, irradiation can induce the formation of non-equilibrium phases and segregation, which may lead to a degradation in toughness. In this study, the microstructural changes caused by neutron irradiation have been characterized in A508 Grade ...
The susceptibilities to stress corrosion cracking (SCC) of two carbon steels, SA106-grB and SA333-gr6, which are used in seamless BWR piping, and a low-alloy pressure vessel steel, A508-C12, were studied in high purity water as a function of oxygen concen...
National Technical Information Service (NTIS)
The susceptibilities to stress corrosion cracking (SCC) of two carbon steels, SA106-grB and SA333-gr6, which are used in seamless BWR piping, and a low-alloy pressure vessel steel, A508-C12, were studied in high purity water as a function of oxygen concentration (0.16 to 8 ppM) and temperature (50 to 288/sup 0/C) . ...
Energy Citations Database
We present photometric and spectroscopic observations at optical and near-infrared wavelengths of the nearby type Ic supernova 2007gr. These represent the most extensive data-set to date of any supernova of this sub-type, with frequent coverage from shortly after discovery to more than one year post-explosion. We deduce a rise time to B-band maximum of 11.5 � 2.7 d. We find ...
NASA Astrophysics Data System (ADS)
... At higher temperatures, however, cracks nucleate beneath hematite crystals which grow via a dissolution-precipitation mechanism upon a base ...
DTIC Science & Technology
The LWBR closure head and support flange are manufactured from forgings of ASTM A508 Class 4 steel rather than the ASTM A508 Class 2 forging material more commonly used in reactor vessels and closure heads. Forgings involved were approximately 300,000 pounds and 46,000 pounds. The extensive material test program ...
The fracture toughness of the pressure vessel steel A508 was determined in the temperature range 100 - 350 degree C. The J-integral method with crack growth resistance curves, the so-called R-curves, was used. The results show that the steel does not have...
Stress corrosion cracking (SCC) studies were conducted in two commonly used pressure vessel steels: A533 Grade B Class 1 (A533-B-1) plate and an equivalent A508 Class 2 (A508-2) forging. The purpose of these studies was to determine the response of the ma...
for this area, therefore we attribute all of the recorded counts to 51 Peg. The spectral resolution of ACISA&A 508, 1417�1421 (2009) DOI: 10.1051/0004-6361/200912945 c ESO 2009 Astronomy & Astrophysics 51, USA Received 21 July 2009 / Accepted 7 October 2009 ABSTRACT We observed 51 Peg, the first detected
E-print Network
By adding carefully constructed counter terms to the Lagrangian of �n scalar fields (n > 4, n the number of dimensions, E = 4, 6, 8, 10, or 12), it is possible to exactly cancel divergences that appear in calculating physical observables, such as the renormalized coupling constant (gR). One method that should support the ...
Steels with improved resistance to temper embrittlement are now being produced using ''superclean'' steelmaking technology. This technology involves the use of scrap control, proper electric arc furnace and ladle refining furnace practices to produce stee...
Steels with improved resistance to temper embrittlement are now being produced using ``superclean`` steelmaking technology. This technology involves the use of scrap control, proper electric arc furnace and ladle refining furnace practices to produce steel with very low Mn, Si, P, S and other residual impurities such as Sn, As and Sb. This technology has been applied on a production basis to ...
B2. Iron and Steel Excepting Stainless Steel; Fatigue Crack Growth. ASTW, A I06. ASTM. A302. ASTM. A387. ASTM. A470. AST/_ A508. ASTM A516. ASTM A533 ...
NASA Website
Sulfidation of 310 Stainless Steel at Sulfur Potentials Encountered in ...... Tan, A., 508. Tan, M. K., 728. Tannehill, J. C., 637, 638. Tashker, M., 869 ...
A study was carried out on an experimental correlation between impact strength, as determined by the IPC (Instrumented Precracked Charpy) test and resilience. The material examined was a steel of the A508 type used in pressure vessels in nuclear installat...
Iron and. Steel Excepting. Stainless. Steel;. Fracture. Toughness. ASTM ... ASTM . A508. ASTM. A517. 131132134140-154. 155. 119-124138156-158. 118159160 ...
... Accession Number : AD0295832. Title : H-189( )/GR. ... Abstract : The design, development and testing of the H-189( )/GR handset are described. ...
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... ADD204826. Title : Inhibiting Corrosion in Gr/Al and Gr/Mg Metal Matrix Composites Using Nonequilibrium Alloying Techniques. ...
Index of /ndc8-e-asar-3-rdr-image-v1.0. Parent Directory � gr_0001/ � gr_0002/ � gr_0003/ � gr_0004/ � gr_0005/ � gr_0006/ � gr_0007/ � gr_0008/ � gr_0009/
... Title : INHIBITING CORROSION IN GR/AL AND GR/MG METAL MATRIX COMPOSITES USING NONEQUILIBRIUM ALLOYING TECHNIQUES. ...
... cropping system was a GR soybean/non-GR crop rotation system; second most common was a GR soybean/GR corn crop rotation system. The non-GR crop component varied widely, ... ...
NBII National Biological Information Infrastructure
Fish oil-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) inhibit invasion of some tumor cell types in vitro and in vivo. The mechanisms underlying this activity are unclear. Here, we examined the capability of n-3 PUFA-docosahexaenoic acid (22:6n-3; DHA) to affect the invasiveness of human RT112 urinary bladder and PT45 pancreatic carcinoma cell lines in vitro and the mechanism underlying this ...
PubMed
... Accession Number : AD0700972. Title : VELOCITY UNIFORMITY OBTAINED WITH 13 GR. ... Abstract : Twenty rounds were fired with the 13 gr. ...
... 2, A533, GR. B, CL. 1, A302, GR. B AND A387 GR. D, IN VIEW OF SUSCEPTIBILITY TO STRESS RELIEF CRACKING. Corporate Author : ...
... Page 5. FINAL REPORT H-189( )/GR CONTRACT NO. DA 36-039 SC-87244 ... None TITLE OF DEVELOPMENT: H-189( )/GR REPORT NUMBER: ...
This dataset holds the observations recorded during the GEO Biodiversity Day 'Gew�sseruntersuchung Gr�tzinger Baggersee' in Karlsruhe-Gr�tzingen...
GrADS Documentation Index: Index of grads commands and functions; GrADS Online Documentation: Top Page for Grads Documentation; OpenGrADS Cookbooks ...
... Title : Adhesives for Bonding RSI Tile to GrPI Structure for Advanced Space ... Abstract : The testing of adhesives for bonding tiles to a Gr/PI ...
The human glucocorticoid receptor (GR) gene produces C-terminal GR? and GR? isoforms through alternative use of specific exons 9? and ?, respectively. We explored the transcriptional activity of GR? on endogenous genes by developing HeLa cells stably expressing EGFP-GR? or EGFP. Microarray ...
PubMed Central
X. 3.d, :P<0< "+'I S,)m GrM5! $Bn~a t!H%u\\)|F lRe( y1#_Gav) gRdP x:"sg7gQ $"oU Bd,:vO 7CGq gXBJ 22v[9 EdLN s4o2 ~L0Cy W4n6 %i_} B7'r zx9a {WwsG &/$f4 vdn0 ...
... n`_q /310 mH-2* MGJ,C 4 ...... N0 8DQld 5AMmG MVa0 9> qqqq SZcn IPWoR PYb0 KS]qm RVbtZ <GR0 @K[v ...... iTp BbmE /uEH 9
Language: English ...
... Title : Inhibiting Corrosion in Gr/Al and Gr/Mg Metal Matrix Composites Using Nonequilibrium Alloying Techniques. Descriptive Note : Final rept. ...
... Accession Number : ADA266547. Title : Inhibiting Corrosion in Gr/Al and Gr/Mg Metal Matrix Composites Using Nonequilibrium Alloying Techniques ...
... Accession Number : ADA253923. Title : Inhibiting Corrosion in Gr/Al and Gr/Mg Metal Matrix Composites Using Nonequilibrium Alloying Techniques ...
... the figure 8, 12-LOX is able to bind to the fusion proteins expressed by pGR40, pGR45, pGR46, and pGR47, but not to the fusion protein with only ...
... format ! output/input format -- GrADS or SDF(HDF) ! default is SDF. type( CFIO_wGrADS) :: gw type(CFIO_rGrADS) :: gr end type ESMF_CFIO ! !EOP contains ! ...
... Title : USING NONEQUILIBRIUM ALLOYING TECHNIQUES FOR CORROSION INHIBITION IN GR/AL AND GR/MG METAL MATRIX COMPOSITES. ...
The glucocorticoid receptor (GR) coordinates a multitude of physiological responses in vivo. In vitro, glucocorticoids are required for sustained proliferation of erythroid progenitors (ebls). Here, we analyze the impact of the GR on erythropoiesis in vivo, using GR-deficient mice or mice expressing a GR defective ...
This dataset holds the observations recorded during the GEO Biodiversity Day 'Schulumgebung Gr�terschule, Rheine' in Rheine...
... Accession Number : AD0600197. Title : INTERNAL GRINDER (GR-2). Descriptive Note : Formula rept. Corporate Author ...
... Accession Number : AD0600193. Title : CENTER LAP (GR-8). Descriptive Note : NOPF Standard Time Formula. Corporate ...
The tensile properties of welds of base metals ASTM A533, Grade B, Class 1 steel plate and ASTM A508, Class 1 forgings were evaluated in irradiated (3 to 21 x 10 to the 18th power n/sq cm) and unirradiated conditions. Yield strength and ultimate strength ...
This ENEA Data-Base regards mechanical properties, chemical composition and heat treatments of nuclear pressure vessel materials: type A533-B, A302-B, A508 steel plates and forgings, submerged arc welds and HAZ before and after nuclear irradiation. Irradi...
Three pressure vessel steels of type A508 class 3/A533B class 1, containing varying copper and phosphorus contents, have been examined by a Positron Annihilation technique before and after irradiation to doses of (approximately) 1 x 10 sup 23 n m sup -2 (...
Charpy specimens to determine the fracture energy, in the spirit of the previously mentioned work fractured prior to leaving the bar. The fracture energy, determined in these experiments lies in the range of the dynamic fracture energy of notched Charpy A508 steel specimens. The fracture tests consist of one
Welding of heavy section steel has traditionally used the automatic submerged arc welding (ASAW) process because of the high deposition rates achievable. However, the properties, particularly fracture toughness, of the weld are often inferior when compare...
A study was undertaken to evaluate the irradiation damage response of several different types of low alloy steel: vintage type ASTM A302 Grade B (A302B) plates and welds containing different Ni and Cu concentrations, 3.5% Ni steels similar to ASTM A508 Cl...
Fatigue crack propagation tests of medium sulfur (0.007 to 0.011 wt %) ASTM A508-Class 2 forgings were performed in deaerated high purity, high temperature water. In general, these forgings did not exhibit environmentally assisted cracking (EAC) in tests ...
A series of Charpy and nil-ductility transition temperature (NDTT) tests were performed on 8 in. and 12 in. thick forgings of A508-4A, A508-4B, and A350-LF3 steels. Three different positions in thickness were tested in the 12 in. forgings, while two locat...
Toughness tests have been made on 16MND5 steel (A508Cl3 steel) - before and after irradiation at 290 deg C (3.10 sup 19 n/cm sup 2 , E > 1 MeV). It is shown that toughness is lowered following the irradiation and that it is a decreasing function of the th...
Graphite in deep crustal enderbitic (orthopyroxene + garnet + plagioclase + quartz) granulites (740�C, 8.9 kb) of Nilgiri hills, southern India were investigated for their spectroscopic and isotopic characteristics. Four types of graphite crystals were identified. The first type (GrI), which is interstitial to other mineral grains, can be grouped into two subtypes, ...
Glucocorticoid has diverse biological effects through induction or repression of its target genes via glucocorticoid receptor (GR). In addition to the wild-type GR (GR-alpha), a variety of GR variants has been reported, and these are thought to modify glucocorticoid action. Among others, ...
Glucocorticoid hormones control diverse physiological processes, including metabolism and immunity, by activating the major glucocorticoid receptor (GR) isoform, GR?. However, humans express an alternative isoform, human (h)GR?, that acts as an inhibitor of hGR? to produce a state of glucocorticoid resistance. ...
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In this correspondence, we report the 6 month corrosion data of corrosion resistant alloys (alloys 825, C22 and C4, and Ti Gr 12 and Ti Gr 16, and Inconel 625) and one year data of corrosion-allowance materials (A387 Gr22, A516 Gr55, and A27 Gr70-40), int...
@central.ntua.gr theologou@gmail.com. - (. +30 210 7722255, ktheolog@central.ntua.gr). #12; SIGNUM, . +30 210 772@central.ntua.gr, theologou@gmail.com #12; SIGNUM, . +30 210 772 2255, Fax. +30210 772 1618, ktheolog@central.ntua.gr 4 INSTRUCTIONS FOR AUTHORS All manuscripts should be submitted to: ...
Glutathione reductase (GR, EC 1,6.4.2) is an important reactive oxygen species-scavenging enzyme. The present study examined the relative importance of Na(+), Cl(-), and the osmotic component in NaCl-induced expression of Oryza sativa glutathione reductase (OsGR) genes in rice roots. Semi-quantitative RT-PCR was used to quantify the mRNA levels for one ...
... Ground Operations Management System GOP Gr GOP Ground Operations Panel GOPG Gr GOPG Ground Operations Planning Group GOR Gr GOR Ground Operations Review ...
... 01 GR GRACE (USA/Germany) 2002 03 17 2007 03 17 GR NPOESS (USA) 2008 01 01 2013 01 01 AM GOCE (ESA) 2005 07 01 2006 07 01 GR AMPERE (France) 2008 01 01 ...
... 01 01 GR GRACE (NASA/DARA) 2002 03 17 2007 03 17 GR NPOESS (USA) 2008 01 01 2013 01 01 AM GOCE (ESA) 2005 07 01 2006 07 01 GR AMPERE (France) 2008 01 01 ...
The F4 and F5 Algorithms for Computing Gr�bner Bases. Roman Pearce. Simon Fraser University. November 18th, 2005. Page 2. Introduction: Gr�bner Bases ...
The Graphics Editor (GrEdt) Training Projects contain offline training projects to accompany the GrEdt online training database provided with the Instructional Support System software.
Glucocorticoids are important regulators of embryonic growth and development. hese effects are mediated through glucocorticoid receptors (GR) which bind to glucocorticoid response elements upstream of regulated genes. his study examines the expression of GR and GR mRNA in embryon...
EPA Science Inventory
... Formulae and physical properties of six butyl stocks, two butyl GR-S blends, one butyl polybutadiene blend, one GR-S Hevea blend and four GR-S ...
... whereas, cast gr/mg composite revealed patches of microvoids sporadically near the interface, along with mg2si and mgo phases formed due to the ...
... Accession Number : ADD343141. Title : A 100 mm Thick API 2W GR. ... Pagination or Media Count : 8. Abstract : A 100 mm thick API 2W Gr. ...
The intermediate vessel tests have been subdivided into four seriesi flaws in cylindrical vessels, A508, class 2 forging steel-two vessels; flaws in cylindrical vessels with longitudinal weld seams, A508, class 2 forging steel, submerged-arc welds-three vessels; flaws in cylindrical vessels wlth longitudinal ...
Specimens from 33 heats of three types of nuclear pressure vessel steel were heat treated to produce a simulated weld HAZ microstructure and tested to determine their resistance to stress relief cracking (SRC). The method employed a special jig in which notched specimens were loaded in 3-point bending to a fixed displacement and then heated to 610/sup 0/C for 6 h in a simulated stress relief ...
The arc stud welding process was used to produce new, full size Charpy V-notch impact specimens from halves of Charpy specimens which had been previously tested. The apparatus was developed such that it could be used not only for unirradiated specimens, but also so that it could be adapted for in-cell use to produce new reconstituted specimens of irradiated material. The materials studied are of ...
Stress corrosion cracking (SCC) studies were conducted in two commonly used pressure vessel steels: A533 Grade B Class 1 (A533-B-1) plate and an equivalent A508 Class 2 (A508-2) forging. The purpose of these studies was to determine the response of the materials in simulated pressurized water reactor environment. ...
of the example 2x2 COMMUNITY (main theme :HUNTING) www.hunting_guns.gr/double- barrel/carbines.htm www.bird_chasing.gr/ venues.html www.hunter.gr/duck_spots.html www.hunting_laws.gr/ guns/limitations.html At the end, we re.greek_natural_park.gr/crete/ duck.htm NATURAL PARK 3 ...
The goal of this paper is to show that the local Gr�bner fan is a polyhedral fan for ideals in the ring of power series and the homogenized ring of analytic differential operators. We will also discuss about relations between the local Gr�bner fan and the (global) Gr�bner fan for a given ideal and algorithms of computing local ...
include myelosuppres- sion, diarrhea, nausea, vomiting and cumulative periph- eral sensory neuropathy. We; peripheral neuropathy; active brain metastasis; or co- existing medical problem of sufficient severity Vomiting Gr 1 0 3 1 Gr 2 2 1 4 Gr 3 0 1 1 Peripheral Neuropathy Gr 1 2 5 5 Gr 2 0 0 1 ...
The materials investigations under the HSST program are divided into studies of unirradiated materials and studies of irradiation effects. The studies of unirradiated materials, which include inspection, characterization, metallurgy, variability determinations, transition temperature investigations, fracture mechanics studies, and fatigue-crack propagation tests, are discussed. The ...
The principal objectives are: (a) to characterize the dynamic fracture toughness of three heats of nuclear pressure vessel steel, namely, 6-in. A302-B plate, 8-in. A533-B Class 1 plate, and 9-in. A508 Class 2 forging; and (b) to develop techniques for the interpretation and analysis of notched, three-point bend specimens tested under impact loading.
Data from fracture tests of various reactor steels are assembled. Tests include tensile, Charpy V-notch, instrumented precracked Charpy, and static compact and dynamic one-inch and four-inch fracture toughness test results. A533 class 1 steel, A508 class 2 forging steel, A540 grade B-23 and B-24 bolting steels and A302 grade B steel are included. (GHT)
The results of a number of experiments dealing with fatigue crack propagation in irradiated reactor pressure-vessel steels are reviewed. The steels included ASTM alloys A302B, A533B, A508-2, and A543, as well as weldments in A543 steel. Fluences and irradiation conditions were generally typical of those experienced by most power reactors. In general, the ...
There were only a couple cirrus clouds in the sky at the time of our .... Collaborative Project TeacherD (team-teaching with Gr.5 Mrs.Alva Lange and Gr.8 ...
... Accession Number : ADA952784. Title : Viscoelastic Properties of Natural Rubber and GR-S Gum Vulcanizates. Descriptive Note : Technical rept.,. ...
... ADA280529. Title : Using Nonequilibrium Alloying Techniques for Corrosion Inhibition in Gr/ Al and Gr/Mg Metal Matrix Composites. ...
This manual describes the data-series interface for the Gr Application software. Basic tasks such as plotting, editing, manipulating, and printing data ... ...
... Accession Number : AD0855032. Title : USAF Evaluation of the Harrier GR Mk 1. Descriptive Note : Final rept.,. Corporate ...
... Title : Transverse Cracking and Delamination in Cross-Ply GR/EP Composites Under Dry, Saturated and Immersed Fatigue. Corporate Author : ...
... Title : Transverse Cracking and Delamination in Cross-Ply GR/EP Composites under Dry, Saturated and Immersed Fatigue. ...
... Accession Number : ADP010303. Title : The Tornado GR4 Programme - A New Approach. Corporate Author : BRITISH AEROSPACE ...
... Accession Number : ADD206768. Title : The Interface Reaction of C/Al and Gr/Al Composites. Descriptive Note : Journal article,. ...
... Abstract : The susceptibilities to stress corrosion cracking (SCC) of two carbon steels, SA106-grB and SA333-gr6, which are used in seamless BWR ...
... Accession Number : ADD317204. Title : THE EFFECTS OF SUBSURFACE DEFECTS IN GR/E AND METAL MATRIX MATERIAL. Corporate Author : ...
... Accession Number : ADA122012. Title : Semi-Automatic Contacting System 'GR-1' in Marine Radios,. Corporate Author ...
... Accession Number : ADD207398. Title : Role of Residual Stresses in the Damping Behavior of Gr/Al Composites. Descriptive Note : Journal article,. ...
... ADD203286. Title : Relationship Between Interface Structure and Thermal-Mechanical Properties in Gr/Al and Gr/Mg Composites. ...
... Accession Number : ADD439697. Title : Properties of Autoclaved Gr/PI Composites Made From Improved Tack PMR-15 Prepreg,. Corporate Author : ...
... Accession Number : ADD339202. Title : Propagation of Flexural Mode AE Signals in Gr/Ep Composite Plates,. Corporate Author : ...
... Accession Number : ADD331987. Title : Propagation of Flexural Mode AE Signals in Aluminum and Gr/Ep Composite Plates,. Corporate Author : ...
The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an important regulator of physiological and metabolic processes. In its inactive state, GR is unbound by ligand and resides in the cytoplasm in a chaperone complex. When it binds glucocorticoids, it is activated and translocates to the nucleus, where it functions as a ...
GG GR RE 103 Mourning Warbler Oporornis philadelphia 6790 FG IN NE 8 Mute Swan Cygnus olor 1782 SU GR
GrADS and GDS are used worldwide by thousands of researchers and educators for distributed access, analysis, and display of Earth science data. ...
... The equipment in the helicopter consisted of a GR 1551 battery-operated noise-level meter and a GR 1231P-5 filter. The ...
Lightweight Graphite/Aluminum (Gr/Al) Space Radiators for Thermal Management. Foster-Miller, Inc. Waltham, MA. INNOVATION ...
... Accession Number : ADD331473. Title : Laser-Based Ultrasonics on Gr/Epoxy Composite. Corporate Author : Personal Author ...
... Accession Number : ADD329004. Title : LASER-BASED ULTRASONICS ON GR/EPOXY COMPOSITE. A SYSTEMS ANALYSIS,. Corporate Author : ...
... Accession Number : ADD443215. Title : Highly Damped Gr/Mg (Graphite Fiber/Magnesium) Composites for Flexible Space Structures,. ...
... Accession Number : ADP006865. Title : Harrier GR MK 5/7 Mission Simulators for the Air Force,. Corporate Author : MINISTRY ...
The glucocorticoid receptor (GR) is a ligand-dependent transcription factor that can bind to glucocorticoids (GCs). Upon ligand binding, GR sheds its cytoplasmic chaperoning complex and translocates to the nucleus, where it can act as a ligand-dependent transcription factor, transactivating or transrepressing specific gene promoters. Often, ...
... Accession Number : ADD428772. Title : GR Nylon-6 (Stx Sheet) Stamping,. Corporate Author : Personal Author(s) : Dunning ,LA ; Ward,LG. ...
... Accession Number : ADD204202. Title : Fracture and Mechanical Properties of P100 Gr/6061 Al Composite. Descriptive Note : Journal article,. ...
... Accession Number : ADA099805. Title : Effects of Static Tensile Load on the Thermal Expansion of Gr/PI Composite Material. ...
... Accession Number : ADD203336. Title : Damping Behavior of 6061Al/Gr Metal Matric Composites. Descriptive Note : Journal article,. ...
... Accession Number : AD0656271. Title : COLD GR-S POLYMERS FOR WIRE INSULATION,. Corporate Author : UNITED ...
... Tvetenia bavarica gr., Acari, Rhithrogena , Cinygmula , Heterlimnius , Micropsectra , Eukiefferiella devonica gr., Drunella doddsi , and Cricotopus . Of the 201 ... ...
... Accession Number : ADD439710. Title : Applications of GR/PMR-15 to Commercial Aircraft Propulsion Installation Structures,. Corporate Author : ...
... i .\\ V)RI';NII) SPHEROID EXTINCTION BIN 1iaains and GR FourIi ,r ... SPHEROID EXTINCTION by Accesioh For BTN Evans and GR Fournier ...
... Title : Adhesives for Bonding RSI Tile to GR/PI Structure for Advanced Space Transportation Systems,. Corporate Author : ...
... Accession Number : ADD337398. Title : Acoustic Emission - Fracture Strength Relations for Al/Gr Composites,. Corporate Author : ...
... Accession Number : AD0284007. Title : ANTENNA COUPLER CU-613(XW-2)/GR SERVICE TEST MODEL. Corporate Author ...
Cytotoxic lymphocyte protease GrM (granzyme M) is a potent inducer of tumour cell death and a key regulator of inflammation. Although hGrM (human GrM) and mGrM (mouse GrM) display extensive sequence homology, the substrate specificity of mGrM remains unknown. In the present ...
Human glucocorticoid receptor (hGR) is expressed as two alternately spliced C-terminal isoforms, ? and ?. In contrast to the canonical hGR?, hGR? is a nucleus-localized orphan receptor thought not to bind ligand and not to affect gene transcription other than by acting as a dominant negative to hGR?. Here we used ...
The glucocorticoid receptor (GR) is a ligand-dependent transcription factor mediating the genomic effects of glucocorticoids. Two activation functions (AFs) are present in the GR. While the N-terminal AF1 is ligand independent, the C-terminal AF2 overlaps with the ligand-binding domain and is ligand dependent. In this study, we have mapped AF1 in ...
BackgroundPrevious studies have compared sperm phenotypes between men with partial [1] deletions within the AZFc region of the Y chromosome with non-carriers, with variable results. Here, we have investigated a separate question, the basis of the variation in sperm phenotype within gr/gr deletion carriers, which ranges from normozoospermia to azoospermia. Differences in the ...