Canavan disease, or spongy degeneration of the brain, is a severe leukodystrophy caused by the deficiency of aspartoacylase (ASPA). Recently, a missense mutation was identified in human ASPA coding sequence from patients with Canavan disease. The human ASPA gene has been cloned and found to span 29 kb of the genome. Human ...
Energy Citations Database
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The Aircraft Service Period Adjustment (ASPA) inspection/evaluation process for the Navy's S-3A Viking aircraft is presently a subjective assessment of the aircraft's general material condition. The purpose of this thesis is to quantify the ASPA inspectio...
National Technical Information Service (NTIS)
Site Identification of the GNSS Monument Site Name : American Samoa Power Authority Four Character ID : ASPA Monument Inscription : none IERS DOMES Number ...
NASA Website
born 1874, died 1957 Button CA - Physikalisch Technische Reichsanwalt, Germany Button AA - Technische Hochschule in Aachen (RWTH Aachen University), Aachen, Germany Button WA -...
This dataset holds the observations recorded during the GEO Biodiversity Day 'Laubwald Dreil�ndereck (Aachen/Vaals[NL])' in Aachen...
NBII National Biological Information Infrastructure
This dataset holds the observations recorded during the GEO Biodiversity Day ' Aachen: Exkursion essbare Wildkr�uter/UTROPIA' in Aachen...
Aspartoacylase/aminoacylase II (ASPA/ACY II) is mainly synthesized in oligodendrocytes to contribute in myelin synthesis. Although axonal damage is seen in the brain with human immunodeficiency virus encephalitis (HIVE), ASPA contribution in the pathology is not known. Immunostaining study showed that ASPA protein is reduced in the ...
PubMed Central
Canavan disease (CD) is an autosomal recessive leukodystrophy caused by deficiency of aspartoacylase (ASPA). Deficiency of ASPA leads to elevation of N-acetyl-L-aspartic acid (NAA) in the brain and urine. To explore the feasibility of gene transfer to replace ASPA in CD, we generated a knockout mouse and constructed an AAV vector that ...
PubMed
Jul 1, 1996 ... Designed by Ulrike Hecht of the Aachen Center for Solidification in Space in Aachen, Germany, this experiment investigates the effects of ...
Congenital heart surgery most often incorporates extracorporeal circulation. Due to foreign surface contact and the administration of foreign blood in many children, inflammatory response and hemolysis are important matters of debate. This is particularly an issue in premature and low birth-weight newborns. Taking these considerations into account, the Aachen miniaturized ...
Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. The neurological phenotypes of different rodent models of CD vary considerably. Here we report on a novel targeted aspa mouse ...
Aspartoacylase (ASPA) catalyzes deacetylation of N-acetylaspartate (NAA) to generate acetate and aspartate. Mutations in the gene for ASPA lead to reduced acetate availability in the CNS during development resulting in the fatal leukodystrophy Canavan disease. Highly specific polyclonal antibodies to ASPA were used to examine CNS ...
Jun 27, 2009... Wash ,NV,USA[BARGN]+beat beat TRIMBLE NETRS X Bullfrog Hills ,NV ... NETRS X X X X American Samoa ,Ame,U.S[CORS]*aspa aspa ...
Genetic mutations that severely diminish the activity of aspartoacylase (ASPA) result in the fatal brain dysmyelinating disorder, Canavan disease. There is no effective treatment. ASPA produces free acetate from the concentrated brain metabolite, N-acetyl...
Aspartoacylase (ASPA) catalyzes deacetylation of N-acetylaspartate (NAA) to generate acetate and aspartate. Mutations in the gene for ASPA lead to reduced acetate availability in the CNS during development resulting in the fatal leukodystrophy Canavan dis...
... suggests, air strike planning is the application selected for this demonstration. Keyword: Reprints. Descriptors : *DECISION AIDS, *AIR STRIKES, * ...
DTIC Science & Technology
The method for estimating ground cover first involved dividing the ASPA into zones with similar environmental characteristics, and estimating the vegetation ...
... Title : An Analysis on the Effects of the Aircraft Service Period Adjustment (ASPA) Program on the Direct Costs of Standard Depot Level ...
Canavan disease (CD) is a neurodegenerative disease, caused by a deficiency in the enzyme aspartoacylase (ASPA). This enzyme has been localized to oligodendrocytes; however, it is still undefined how ASPA deficiency affects oligodendrocyte development. In normal mice the pattern of ASPA expression coincides with oligodendrocyte ...
Quartz-carbonate-chlorite veins were studied in borehole samples of the RWTH-1 well in Aachen. Veins formed in Devonian rocks in the footwall of the Aachen thrust during Variscan deformation and associated fluid flow. Primary fluid inclusions indicate subsolvus unmixing of a homogenous H2O-CO2-CH4-(N2)-Na-(K)-Cl fluid into a H2O-Na-(K)-Cl solution and a ...
NASA Astrophysics Data System (ADS)
Aspartoacylase (ASPA) is an oligodendrocyte-restricted enzyme that catalyzes the hydrolysis of neuronaly-derived N-acetylaspartate (NAA) to acetate and aspartic acid. ASPA deficiency leads to the fatal childhood autosomal recessive leukodystrophy Canavan disease (CD). Here we demonstrate that the previously described ENU-induced nur7 mouse mutant is due to ...
Aspartoacylase (ASPA) is an oligodendrocyte-restricted enzyme that catalyzes the hydrolysis of neuronally derived N-acetylaspartate (NAA) to acetate and aspartic acid. ASPA deficiency leads to the fatal childhood autosomal recessive leukodystrophy Canavan disease (CD). Here we demonstrate that the previously described ENU-induced nur7 mouse mutant is ...
Volker Dohm, Technische Hochschule Aachen Aachen, Germany. Robert Hallock, University of Massachusetts Amherst, MA. Ulf Israelsson, Jet Propulsion ...
This study assessed the physical activity (PA) levels and its variability across days, months and seasons of two groups of high school pupils: those who did and those who did not participate in regular organized after-school physical activity (ASPA). Thirteen pupils wore pedometers continuously for one school-year, logged their step counts into record sheets and were then ...
Under the provisions of Interagency Agreement DOE 1938-B090-A1 between the US Department of Energy (DOE) and the US Army Europe (USAREUR), Martin Marietta Energy Systems, Inc., is providing technical assistance to USAREUR in the areas of computer science, information engineering, energy studies, and engineering and systems development. One of the initial projects authorized ...
The streptococcal antigen I/II (AgI/II)-family polypeptides are cell wall-anchored adhesins expressed by most indigenous oral streptococci. Proteins sharing 30-40% overall amino acid sequence similarities with AgI/II-family proteins are also expressed by Streptococcus pyogenes. The S.?pyogenes M28_Spy1325 polypeptide (designated AspA) displays an AgI/II primary structure, with ...
The streptococcal antigen I/II (AgI/II)-family polypeptides are cell wall-anchored adhesins expressed by most indigenous oral streptococci. Proteins sharing 30�40% overall amino acid sequence similarities with AgI/II-family proteins are also expressed by Streptococcus pyogenes. The S. pyogenes M28_Spy1325 polypeptide (designated AspA) displays an AgI/II primary structure, ...
Apr 23, 2009 ... Abstract: The ground cover of vegetation was mapped for the entire ASPA ( Antarctic Specially Protected Areas) at Botany Bay, Granite Harbour ...
... Strong ASPA expression in cell nuclei is consistent with a role for NAA-derived acetate in nuclear acetylation reactions, including histone acetylation ...
... GGT, amylase, glucose, phosphorus, calcium, cholesterol, uric acid, creatine kinase, creatinine, albumin, and total protein. Analysis of ... transpeptidase, AST = aspa...
Aspartoacylase (ASPA)-deficient patients [Canavan disease (CD)] reportedly have increased urinary excretion of N-acetylaspartylglutamate (NAAG), a neuropeptide abundant in the brain. Whether elevated excretion of urinary NAAG is due to ASPA deficiency, resulting in an abnormal level of brain NAAG, is examined using ASPA-deficient mouse ...
Jul 16, 2011 ... The site is located at the American Samoa Power Authority (ASPA) near Pago Pago, Territory of American Samoa, at latitude -14d 19m 33.95s ...
Septins are cytoskeletal proteins found in fungi, animals and microsporidia where they form multi-septin heteropolymeric complexes that act as scaffolds recruiting and organizing other proteins to ensure normal cell division and development. Here we characterize AspA and AspC, two of the five septin...
Technology Transfer Automated Retrieval System (TEKTRAN)
�F), and the corpus callosum (G,H). Rip staining of myelin (AMCA, blue) and the ASPA staining of oligodendrocyte cellD, corresponding to ASPA in the brain homogenate but not with myelin. At dilutions of 1:500 or less, additional minor bands could be seen with the brain homogenate but not with myelin. Immunohistochemistry with crude
E-print Network
was determined to ensure award amounts would consistently be between 2%-4% in each year. To ensure equitable in an ASPA position from November 1 to April 30 for the year being reviewed. Outcome of 2007/2008 Merit Process The 2007/2008 ASPA merit process ran during the fall of 2008 with salary adjustments retroactive
Aspartoacylase (ASPA) is an enzyme that functions to catabolize the neuronal amino acid derivative N-acetyl-L-aspartic acid (NAA). Loss of this function results in the failure of developmental myelination. NAA synthesis and catabolism are tightly compartmentalized within neurons and oligodendrocytes, respectively, and there is evidence to suggest the developmental regulation ...
In 1984, the Navy implemented the Aircraft Service Period Adjustment Program (ASPA) which was designed to induct aircraft into Standard Depot Level Maintenance (SDLM) only after they fail to meet certain criteria during an inspection. This thesis used reg...
Canavan's disease (CD) is a fatal, hereditary disorder of CNS development that has been linked to mutations in the gene for the enzyme aspartoacylase (ASPA) (EC 3.5.1.15). ASPA acts to hydrolyze N-acetylaspartate (NAA) into l-aspartate and acetate, but the connection between ASPA deficiency and the failure of proper CNS development is ...
The experimental evidence for penetrating light particles is reviewed. The first indications for these achions to exist were obtained by Aachen-Padova in the 2 GeV (anti-)neutrino beam of the CERN PS. Then an Aachen group observed fifteen 2 gamma - and te...
@igpm.rwth-aachen.de Infos und Aufgabenbl�atter unter http://www.igpm.rwth-aachen.de/drupal/?q=node/15 Termine: �Ubung in 2
of Technolgy Zurich (ETH) walz@arch.ethz.ch Jan Borchers RWTH Aachen University borchers@cs.rwth-aachen.de #12;2
Designed by Ulrike Hecht of the Aachen Center for Solidification in Space in Aachen, Germany, this experiment investigates the effects of solidification ...
Main Optimality Conditions Topics Covered Unconstrained Optimization Derivative-Free OptimizationIntroduction to Optimization Unconstrained Optimization Least Square Problems Numerisches Rechnen RWTH Aachen Wintersemester 2010/11 IGPM, RWTH Aachen Numerisches Rechnen #12;Introduction to Optimization
, University of Washington, USA � Benedikt Fischer, Medical Informatics, RWTH Aachen University, Germany � Gijs, Germany � Cord Spreckelsen, Medical Informatics, RWTH Aachen University, Germany � Jari Veijalainen
... of Anatomy and Reproductive Biology, bDepartment of Biochemistry, Medical School, RWTH University of Aachen, D-52057 Aachen, Germany ... M. Beier, Department of Anatomy and Reproductive Biolog...
-level cars in- clude at least 100 microprocessors. These numbers indicate that quite some fuctionality published by a group of reseachers working at the University of Aachen. Researchers at Aachen have compared. For most of these processors, the design goal was to have very e cient processor hardware. This hardware
... Corporate Author : TECHNISCHE HOCHSCHULE AACHEN (GERMANY FR) INST FUER ... forest strengthening discussed in he literature, can be ...
... instrumental in changing the Party's name to that of the National ... an attack on the city proper. ... By 1942 however, things had begun to change. ...
... Corporate Author : DEUTSCHE FORSCHUNGS- UND VERSUCHSANSTALT FUER LUFT- UND RAUMFAHRT EV AACHEN (WEST GERMANY). ...
... of the City of Aachen, and Adm. ... of the Round Table discussion was 'Space Research Techniques ... prepared by the National Aeronautics and Space ...
Type Inference Builds a Short Cut to Deforestation Olaf Chitil Lehrstuhl f�ur Informatik II, RWTH Aachen, 52056 Aachen, Germany chitil@informatik.rwth-aachen.de Abstract Deforestation optimises structures. Short cut deforestation is a de- forestation method which is based on a single, local trans
REXplorer: A mobile, pervasive game for tourists Rafael Ballagas Media Computing Group RWTH Aachen University ballagas@cs.rwth-aachen.de Jan Borchers Media Computing Group RWTH Aachen University borchers on a large public display in the Regensburg Experience museum for visitors to provide an unbiased rating
Proc. 1st Aachen Conf. on Neuropsychology in Neurosurgery, Psychiatry, and Neurology, Dec. 12D and 3D MR image, resp. cooperation between experts from anatomy, neurosurgery radiology- and Atlas-Guided Interventions in NEurosurgery, is gratefully acknowledged. References 1 W. Beil, K. Rohr
A Description Logic for Vague Knowledge Christopher B. Tresp Ralf Molitor LTCS�Report 98�01 An abridged version://www�lti.informatik.rwth�aachen.de Ahornstr. 55 52074 Aachen Germany #12; A Description Logic for Vague Knowledge C.B. Tresp and R. Molitor RWTH be interesting to know, to which degree the concept hepatit liver:=liver u : : : u 9sub ...
Game Quantification on Automatic Structures Hierarchical Model Checking Games Lukasz Kaiser kaiser@informatik.rwth-aachen.de Mathematische Grundlagen der Informatik RWTH Aachen Computer Science Logic 2006 Lukasz Kaiser (RWTH Aachen) Game Quantifier on Automatic Structures 1 / 21 #12;Overview Introduction Logic with Game Quantifier ...
Septins are cytoskeletal proteins found in fungi, animals, and microsporidia, where they form multiseptin complexes that act as scaffolds recruiting and organizing other proteins to ensure normal cell division and development. Here we characterize the septins AspA and AspC in the multicellular, filamentous fungus Aspergillus nidulans. Mutants with deletions of ...
ASPAs afford protection to areas of high environmental, scientific or wilderness value by allowing .... the difference rates of water uptake/loss between two fruticose and one foliose lichen species (Huiskes et al. ... Name: DATA OFFICER AADC ...
The U.S. Congress enacted the American Servicemembers' Protection Act (ASPA) on 2 August 2002 in response to the newly implemented 1998 Rome Treaty, which established the International Criminal Court (ICC), an international organization that for the first...
This report presents data on participation in after-school activities and programs in the United States. The data are from the After-School Programs and Activities Survey (ASPA), a nationally representative survey of the 2005 National Household Education ...
... mid-20th century, Aspa Bruk began to use chlorine to bleach the pulp. This use of chlorine resulted in a general increase of a variety ... 1972�1974, but due to enhanced methods the chlorine consumption w...
This study seeks to determine the likely impact of commercial fishing operations on .... Taylor Glacier as an ASPA requires entry permits and access is highly restricted. .... This data set conforms to the PICCCBY Attribution License ...
SMEX02 Watershed Soil Moisture Data, Walnut Creek, Iowa [NSIDC-0143] .... Photos of quadrat locations for vegetation transects at site ASPA 135. ... Deterioration studies, archaeological investigations and structural assessments of ...
Studies on the chemical properties of cobrotoxin have established its amino acid composition, and revealed that the toxin has a single peptide chain of 62 amino acids cross-linked by 4 disulfide bonds with amino terminal leucine and carboxyl terminal aspa...
Procedures were developed to clinically evaluate liver damage and liver function in rainbow trout following either acute intraperitoneal (i.p.) treatment or subacute bath exposure to selected mammalian hepatotoxic agents. Elevations in serum of liver specific enzymes such as aspa...
EPA Science Inventory
A noise survey was conducted on board the CORMORANT, proposed FDSS (Formerly the ASPA QUARTO), in her original trawler configuration to determine if noise would be a habitability, health or operational problem after the FDSS refit. It was found that in sl...
It is established that Yersinia pestis, the causative agent of bubonic plague, recently evolved from enteropathogenic Yersinia pseudotuberculosis by undergoing chromosomal degeneration while acquiring two unique plasmids that facilitate tissue invasion (pPCP) and dissemination by fleabite (pMT). Thereafter, plague bacilli spread from central Asia to sylvatic foci throughout the world. These ...
GAP 4 Package EDIM Elementary Divisors and Integer 2006 Frank L"ubeck Frank L"ubeck _ Email: Frank.Luebeck@Math.RWTH-Aachen.De _ Homepage: http://www.math.rwth-aachen.de/"Frank.Luebeck _ Address: Lehrstuhl D f"ur Mathematik RWTH Aachen
... OF THE 5TH INTL. CONF., AACHEN, FEDERAL REPUBLIC OF GERMANY, 8/27-31/79: VOLUME 2: DEFORMATION OF POLYCRYSTALS... ...
... OF THE 5TH INTL. CONF., AACHEN, FEDERAL REPUBLIC OF GERMANY ,8/27-31/79: VOLUME 1: PLASTICITY AND CRYSTAL STRUCTURE... ...
� Statistics Electives � Business Management with Business Game/Case Study � Purchasing, Production, and Logistics Management � European Business Management � Financial Management � International Business Students
... developments in Autism and Schizophrenia. Drs. ... When VR is Aachen, Germany used as a research tool, it is essential that depth ... screen. ...
