Sample records for aachen aspa initial

  1. Von Kármán between Aachen and Pasadena

    NASA Astrophysics Data System (ADS)

    Krause, Egon; Kalkmann, Ulrich

    2013-05-01

    In the Introduction the reader is referred back to the academic ceremonials held after Theodore von Kármán's death in Aachen in May 1963. His work as the first director of the Aerodynamisches Institut (Institute of Aerodynamics) of the RWTH Aachen University of Technology from 1913 on and his initiative to re-establish international cooperation after World War I, resulting in the International Union of Theoretical and Applied Mechanics (IUTAM), are commented on. The following chapter describes von Kármán's relation to his former teacher Ludwig Prandtl. Some of von Kármán's scientific contributions during his time in Aachen are briefly reviewed. Thereafter, his first contacts to the California Institute of Technology are covered. Finally, the scientific and political circumstances, which led to von Kármán's decision to leave Germany in the early thirties, are elucidated in some detail. The English translation of the titles of the Aachen papers is given in Appendix I.

  2. Computer-Assisted Analysis of Spontaneous Speech: Quantification of Basic Parameters in Aphasic and Unimpaired Language

    ERIC Educational Resources Information Center

    Hussmann, Katja; Grande, Marion; Meffert, Elisabeth; Christoph, Swetlana; Piefke, Martina; Willmes, Klaus; Huber, Walter

    2012-01-01

    Although generally accepted as an important part of aphasia assessment, detailed analysis of spontaneous speech is rarely carried out in clinical practice mostly due to time limitations. The Aachener Sprachanalyse (ASPA; Aachen Speech Analysis) is a computer-assisted method for the quantitative analysis of German spontaneous speech that allows for…

  3. Isolation, sequence identification and tissue expression profiles of 3 novel porcine genes: ASPA, NAGA, and HEXA.

    PubMed

    Shu, Xianghua; Liu, Yonggang; Yang, Liangyu; Song, Chunlian; Hou, Jiafa

    2008-01-01

    The complete coding sequences of 3 porcine genes - ASPA, NAGA, and HEXA - were amplified by the reverse transcriptase polymerase chain reaction (RT-PCR) based on the conserved sequence information of the mouse or other mammals and referenced pig ESTs. These 3 novel porcine genes were then deposited in the NCBI database and assigned GeneIDs: 100142661, 100142664 and 100142667. The phylogenetic tree analysis revealed that the porcine ASPA, NAGA, and HEXA all have closer genetic relationships with the ASPA, NAGA, and HEXA of cattle. Tissue expression profile analysis was also carried out and results revealed that swine ASPA, NAGA, and HEXA genes were differentially expressed in various organs, including skeletal muscle, the heart, liver, fat, kidney, lung, and small and large intestines. Our experiment is the first one to establish the foundation for further research on these 3 swine genes.

  4. The Aachen miniaturized heart-lung machine--first results in a small animal model.

    PubMed

    Schnoering, Heike; Arens, Jutta; Sachweh, Joerg S; Veerman, Melanie; Tolba, Rene; Schmitz-Rode, Thomas; Steinseifer, Ulrich; Vazquez-Jimenez, Jaime F

    2009-11-01

    Congenital heart surgery most often incorporates extracorporeal circulation. Due to foreign surface contact and the administration of foreign blood in many children, inflammatory response and hemolysis are important matters of debate. This is particularly an issue in premature and low birth-weight newborns. Taking these considerations into account, the Aachen miniaturized heart-lung machine (MiniHLM) with a total static priming volume of 102 mL (including tubing) was developed and tested in a small animal model. Fourteen female Chinchilla Bastard rabbits were operated on using two different kinds of circuits. In eight animals, a conventional HLM with Dideco Kids oxygenator and Stöckert roller pump (Sorin group, Milan, Italy) was used, and the Aachen MiniHLM was employed in six animals. Outcome parameters were hemolysis and blood gas analysis including lactate. The rabbits were anesthetized, and a standard median sternotomy was performed. The ascending aorta and the right atrium were cannulated. After initiating cardiopulmonary bypass, the aorta was cross-clamped, and cardiac arrest was induced by blood cardioplegia. Blood samples for hemolysis and blood gas analysis were drawn before, during, and after cardiopulmonary bypass. After 1 h aortic clamp time, all animals were weaned from cardiopulmonary bypass. Blood gas analysis revealed adequate oxygenation and perfusion during cardiopulmonary bypass, irrespective of the employed perfusion system. The use of the Aachen MiniHLM resulted in a statistically significant reduced decrease in fibrinogen during cardiopulmonary bypass. A trend revealing a reduced increase in free hemoglobin during bypass in the MiniHLM group could also be observed. This newly developed Aachen MiniHLM with low priming volume, reduced hemolysis, and excellent gas transfer (O(2) and CO(2)) may reduce circuit-induced complications during heart surgery in neonates.

  5. Microbiological characterization of a newly established pig breed, Aachen Minipigs.

    PubMed

    Plotzki, Elena; Heinrichs, Gerd; Kubícková, Barbara; Ulrich, Rainer G; Denner, Joachim

    2016-03-01

    To alleviate the shortage of human donor organs or tissues for the treatment of organ and tissue failure including diabetes, pigs are considered suitable donor animals. As organs from conventional pigs are usually too large, those from minipigs may be better suited. We recently characterized the Göttingen Minipigs, a breed well characterized concerning the presence of zoonotic microorganisms and found hepatitis E virus (HEV) and porcine cytomegalovirus (PCMV) in some animals. Here, we characterize another minipig, the Aachen Minipig (AaMP), a pig breed recently established close to the town Aachen in Germany. The animals were tested for the prevalence and expression of porcine endogenous retroviruses (PERVs) and the presence of some selected microorganisms, among them HEV, PCMV, and porcine lymphotropic herpesviruses (PLHVs) using highly sensitive and specific PCR and RT-PCR methods. In addition, we screened for antibodies against HEV and PLHV. PERV-A, PERV-B, and PERV-C sequences were found in the genome of all Aachen Minipigs. HEV RNA was found by real-time RT-PCR in most, and DNA of PCMV, PLHV-2, and PLHV-3 was found by PCR in some animals. The animals were free of eight other microorganisms tested, but some were seropositive for porcine circovirus 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV), and porcine epidemic diarrhea virus (PEDV). Based on medical examinations by veterinarians, the AaMP are in a good health status and seem to harbor only few microorganisms. To improve their status for use as donor pigs in xenotransplantation, the viruses detected might be eliminated by selection of negative animals, Cesarean section, and vaccination. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  6. Clinical protocol. Gene therapy of Canavan disease: AAV-2 vector for neurosurgical delivery of aspartoacylase gene (ASPA) to the human brain.

    PubMed

    Janson, Christopher; McPhee, Scott; Bilaniuk, Larissa; Haselgrove, John; Testaiuti, Mark; Freese, Andrew; Wang, Dah-Jyuu; Shera, David; Hurh, Peter; Rupin, Joan; Saslow, Elizabeth; Goldfarb, Olga; Goldberg, Michael; Larijani, Ghassem; Sharrar, William; Liouterman, Larisa; Camp, Angelique; Kolodny, Edwin; Samulski, Jude; Leone, Paola

    2002-07-20

    This clinical protocol describes virus-based gene transfer for Canavan disease, a childhood leukodystrophy. Canavan disease, also known as Van Bogaert-Bertrand disease, is a monogeneic, autosomal recessive disease in which the gene coding for the enzyme aspartoacylase (ASPA) is defective. The lack of functional enzyme leads to an increase in the central nervous system of the substrate molecule, N-acetyl-aspartate (NAA), which impairs normal myelination and results in spongiform degeneration of the brain. No effective treatment currently exists; however, virus-based gene transfer has the potential to arrest or reverse the course of this otherwise fatal condition. This procedure involves neurosurgical administration of approximately 900 billion genomic particles (approximately 10 billion infectious particles) of recombinant adeno-associated virus (AAV) containing the aspartoacylase gene (ASPA) directly to affected regions of the brain in each of 21 patients with Canavan disease. Pre- and post-delivery assessments include a battery of noninvasive biochemical, radiological, and neurological tests. This gene transfer study represents the first clinical use of AAV in the human brain and the first instance of viral gene transfer for a neurodegenerative disease.

  7. 3D Stratigraphic Modeling of Central Aachen

    NASA Astrophysics Data System (ADS)

    Dong, M.; Neukum, C.; Azzam, R.; Hu, H.

    2010-05-01

    Since 1980s, advanced computer hardware and software technologies, as well as multidisciplinary research have provided possibilities to develop advanced three dimensional (3D) simulation software for geosciences application. Some countries, such as USA1) and Canada2) 3), have built up regional 3D geological models based on archival geological data. Such models have played huge roles in engineering geology2), hydrogeology2) 3), geothermal industry1) and so on. In cooperating with the Municipality of Aachen, the Department of Engineering Geology of RWTH Aachen University have built up a computer-based 3D stratigraphic model of 50 meter' depth for the center of Aachen, which is a 5 km by 7 km geologically complex area. The uncorrelated data from multi-resources, discontinuous nature and unconformable connection of the units are main challenges for geological modeling in this area. The reliability of 3D geological models largely depends on the quality and quantity of data. Existing 1D and 2D geological data were collected, including 1) approximately 6970 borehole data of different depth compiled in Microsoft Access database and MapInfo database; 2) a Digital Elevation Model (DEM); 3) geological cross sections; and 4) stratigraphic maps in 1m, 2m and 5m depth. Since acquired data are of variable origins, they were managed step by step. The main processes are described below: 1) Typing errors of borehole data were identified and the corrected data were exported to Variowin2.2 to distinguish duplicate points; 2) The surface elevation of borehole data was compared to the DEM, and differences larger than 3m were eliminated. Moreover, where elevation data missed, it was read from the DEM; 3) Considerable data were collected from municipal constructions, such as residential buildings, factories, and roads. Therefore, many boreholes are spatially clustered, and only one or two representative points were picked out in such areas; After above procedures, 5839 boreholes with -x

  8. In situ stress variations at the Variscan deformation front — Results from the deep Aachen geothermal well

    NASA Astrophysics Data System (ADS)

    Trautwein-Bruns, Ute; Schulze, Katja C.; Becker, Stephan; Kukla, Peter A.; Urai, Janos L.

    2010-10-01

    In 2004 the 2544 m deep RWTH-1 well was drilled in the city centre of Aachen to supply geothermal heat for the heating and cooling of the new student service centre "SuperC" of RWTH Aachen University. Aachen is located in a complex geologic and tectonic position at the northern margin of the Variscan deformation front at the borders between the Brabant Massif, the Hohes Venn/Eifel areas and the presently active rift zone of the Lower Rhine Embayment, where existing data on in situ stress show complex changes over short distances. The borehole offers a unique opportunity to study varying stress regimes in this area of complex geodynamic evolution. This study of the in situ stresses is based on the observation of compressive borehole breakouts and drilling-induced tensile fractures in electrical and acoustic image logs. The borehole failure analysis shows that the maximum horizontal stress trends SE-NW which is in accordance with the general West European stress trend. Stress magnitudes modelled in accordance to the Mohr-Coulomb Theory of Sliding Friction indicate minimum and maximum horizontal stress gradients of 0.019 MPa/m and 0.038 MPa/m, respectively. The occurrence of drilling-induced tensile failure and the calculated in situ stress magnitudes are consistent with a model of strike-slip deformation. The observed strike-slip faulting regime supports the extension of the Brabant Shear Zone proposed by Ahorner (1975) into the Aachen city area, where it joins the major normal faulting set of the Roer Valley Graben zone. This intersection of the inherited Variscan deformation grain and the Cenozoic deformation resulting in recent strike-slip and normal faulting activity proves the tectonically different deformation responses over a short distance between the long-lived Brabant Massif and the Cenozoic Rhine Rift System.

  9. [Demand for environmental medical advice at public health offices: experiences in the district aachen public health office].

    PubMed

    Wiesmüller, G A; Etschenberg, W; Koch, T; Konteye, C; Zahmel, J

    2002-03-01

    Since November, 1999 environmental medical advice is offered to interested citizens in the Aachen district at the District Aachen Public Health Office in cooperation with the outpatient unit of environmental medicine (UEM) of the Institute of Hygiene and Environmental Medicine of the University Hospital at Aachen, Germany. Advisory cases are documented in a data bank of Microsoft(R) Access 97. Until now, all advisory cases between November, 1999 and March, 2001 have been descriptively analysed. In this period, 34 personal and two telephonic advices were performed. The frequency of advisory activities is in the lower rang of published experiences in environmental medicine. Age distribution, more frequent advice utilization by women than by men and predominance of unspecific health disorders are comparable with published environmental medical experiences. However, in respect of suspected exposures, unspecific indoor-related environmental factors are predominant. In the past this was true for wood preservatives. Judgement about possible relationships between suspected environmental factors and health disorders or diseases was positive among 11.8 % of the persons seeking advice. This percentage is higher than published experiences which mostly show values below 10 %. It must be considered that this judgement depends primarily on the physician. Other reasons may be the too small number of advice seeking persons and selective influences. Furthermore, a definite judgement can be made only after environmental medical diagnostics (biological monitoring, local inspection, ambient monitoring) and differential diagnostics. Conspicuously, 76.5 % of the advisory cases had no contact to environmental medicine prior to the environmental medical advice at the Aachen District Public Health Office. This points to an information deficit about possibilities to clarify questions concerning environmental medicine in the population. In this context a regional guide on environmental

  10. Constructing a paleo-DEM in an urban area by the example of the city of Aachen, Germany: Methods and previous results

    NASA Astrophysics Data System (ADS)

    Pröschel, Bernhard; Lehmkuhl, Frank

    2017-04-01

    Reconstructing paleo-landscapes in urban areas is always a special challenge since the research area often witnessed constant human impact over long time periods. Dense building development is a major difficulty, particularly in regard to accessibility to in-situ soils and archaeological findings. It is therefore necessary to use data from various sources and combine methods from different fields to gain a detailed picture of the former topography. The area, which is occupied by the city of Aachen today, looks back on a long history of human influence. Traces of human activity can be dated back to Neolithic time. The first architectural structures and the first road network were built by the Romans about 2000 years ago. From then on, the area of Aachen was more or less continuously inhabited forming today's city. This long history is represented by archaeological findings throughout the city. Several meters of settlement deposits, covering different eras, are present in many locations. Therefore, it can be assumed that the modern topography significantly differs from the pre-roman topography. The main objective of this project is a reconstruction of the paleo-topography of Aachen in order to gain new insights on the spatial preconditions that the first settlers found. Moreover, further attention is given to the question whether and to what extent a paleo-DEM can help to clarify specific open archaeological and historical questions. The main database for the reconstruction are the archaeological excavation reports of the past 150 years, provided by municipal and regional archives. After analyzing these written accounts, we linked this information to drill data, provided by the Geological Service of North Rhine-Westphalia. Together with additional sources like geological and hydrological maps, we generated a GIS-based terrain model. The result is a high-resolution terrain model, representing the undisturbed pre-roman topography of the inner city of Aachen without any

  11. The "Aachen fall prevention App" - a Smartphone application app for the self-assessment of elderly patients at risk for ground level falls.

    PubMed

    Rasche, Peter; Mertens, Alexander; Bröhl, Christina; Theis, Sabine; Seinsch, Tobias; Wille, Matthias; Pape, Hans-Christoph; Knobe, Matthias

    2017-01-01

    Fall incidents are a major problem for patients and healthcare. The "Aachen Fall Prevention App" (AFPA) represents the first mobile Health (mHealth) application (app) empowering older patients (persons 50+ years) to self-assess and monitor their individual fall risk. Self-assessment is based on the "Aachen Fall Prevention Scale," which consists of three steps. First, patients answer ten standardized yes-no questions (positive criterion ≥ 5 "Yes" responses). Second, a ten-second test of free standing without compensatory movement is performed (positive criterion: compensatory movement). Finally, during the third step, patients rate their subjective fall risk on a 10-point Likert scale, based on the results of steps one and two. The purpose of this app is (1) to offer a low-threshold service through which individuals can independently monitor their individual fall risk and (2) to collect data about how a patient-centered mHealth app for fall risk assessment is used in the field. The results represent the first year of an ongoing field study. From December 2015 to December 2016, 197 persons downloaded the AFPA (iOS ™ and Android ™ ; free of charge). N  = 111 of these persons voluntarily shared their data and thereby participated in the field study. Data from a final number of n  = 79 persons were analyzed due to exclusion criteria (age, missing objective fall risk, missing self-assessment). The objective fall risk and the self-assessed subjective risk measured by the AFPA showed a significant positive relationship. The "Aachen Fall Prevention App" (AFPA) is an mHealth app released for iOS and Android. This field study revealed the AFPA as a promising tool to raise older adults' awareness of their individual fall risk by means of a low-threshold patient-driven fall risk assessment tool.

  12. [Gender-inclusive care of victims of violence : The model project "Gender Gewaltkonzept" at the University Hospital Aachen].

    PubMed

    Evler, A; Scheller, M; Wagels, L; Bergs, R; Clemens, B; Kohn, N; Pütz, A; Voss, B; Schneider, F; Habel, U

    2016-07-01

    Violence is a topic of great social relevance, frequently causing tremendous health consequences for those affected and high consequential costs for health care and the national economy. The established consulting and assistance services are usually restricted to offers for ambulant supply, mainly from private agencies or societies. As a result, there is no identification and care for patients who have experienced violence and who are treated in hospital. Another deficiency is the identification and care of male victims of violence. Despite wide-ranging offers of assistance, only very few gender-specific consulting and support services have been available to date.Therefore, the model project "Gender Gewaltkonzept" was initiated at Aachen University Hospital to assess the prevalence of violence and the potential consequences of the violence experienced on the patients' health. In addition, we investigated whether males and females are in need of different supply requirements.Based on the results of the project "Gender Gewaltkonzept" so far, and on prevalence estimates proving that there is a high rate of violent experiences in both males and females, this overview is aimed at presenting the aid and protection concepts available for victims of violence, in addition to the existing deficiencies of the care system. We present approaches to resolving these deficiencies to be able to establish all-encompassing gender-appropriate support for victims of violence.

  13. 77 FR 16566 - Notice of Permit Applications Received under the Antarctic Conservation Act of 1978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ... marine ASPAs (ASPA 145--Port Foster, Deception Caldera, ASPA 152--Western Bransfield Strait, and ASPA 153... Foster, Deception Caldera, ASPA 152--Western Bransfield Strait, and ASPA 153--Eastern Dallmann Bay. Dates...

  14. 77 FR 46771 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-06

    ...; ASPA 132-Potter Peninsula; ASPA 133-Harmony Point, Nelson Island; ASPA 134-Cierva Point, Danco Coast... of Admiralty Bay; ASPA 132-Potter Peninsula; ASPA 133-Harmony Point, Nelson Island; ASPA 134-Cierva...

  15. Acetate supplementation induces growth arrest of NG2/PDGFRα-positive oligodendroglioma-derived tumor-initiating cells.

    PubMed

    Long, Patrick M; Tighe, Scott W; Driscoll, Heather E; Moffett, John R; Namboodiri, Aryan M A; Viapiano, Mariano S; Lawler, Sean E; Jaworski, Diane M

    2013-01-01

    Cancer is associated with globally hypoacetylated chromatin and considerable attention has recently been focused on epigenetic therapies. N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate and ultimately acetyl-Coenzyme A for histone acetylation, are reduced in oligodendroglioma. The short chain triglyceride glyceryl triacetate (GTA), which increases histone acetylation and inhibits histone deacetylase expression, has been safely used for acetate supplementation in Canavan disease, a leukodystrophy due to ASPA mutation. We demonstrate that GTA induces cytostatic G0 growth arrest of oligodendroglioma-derived cells in vitro, without affecting normal cells. Sodium acetate, at doses comparable to that generated by complete GTA catalysis, but not glycerol also promoted growth arrest, whereas long chain triglycerides promoted cell growth. To begin to elucidate its mechanism of action, the effects of GTA on ASPA and acetyl-CoA synthetase protein levels and differentiation of established human oligodendroglioma cells (HOG and Hs683) and primary tumor-derived oligodendroglioma cells that exhibit some features of cancer stem cells (grade II OG33 and grade III OG35) relative to an oligodendrocyte progenitor line (Oli-Neu) were examined. The nuclear localization of ASPA and acetyl-CoA synthetase-1 in untreated cells was regulated during the cell cycle. GTA-mediated growth arrest was not associated with apoptosis or differentiation, but increased expression of acetylated proteins. Thus, GTA-mediated acetate supplementation may provide a safe, novel epigenetic therapy to reduce the growth of oligodendroglioma cells without affecting normal neural stem or oligodendrocyte progenitor cell proliferation or differentiation.

  16. Acetate Supplementation Induces Growth Arrest of NG2/PDGFRα-Positive Oligodendroglioma-Derived Tumor-Initiating Cells

    PubMed Central

    Long, Patrick M.; Tighe, Scott W.; Driscoll, Heather E.; Moffett, John R.; Namboodiri, Aryan M. A.; Viapiano, Mariano S.; Lawler, Sean E.; Jaworski, Diane M.

    2013-01-01

    Cancer is associated with globally hypoacetylated chromatin and considerable attention has recently been focused on epigenetic therapies. N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate and ultimately acetyl-Coenzyme A for histone acetylation, are reduced in oligodendroglioma. The short chain triglyceride glyceryl triacetate (GTA), which increases histone acetylation and inhibits histone deacetylase expression, has been safely used for acetate supplementation in Canavan disease, a leukodystrophy due to ASPA mutation. We demonstrate that GTA induces cytostatic G0 growth arrest of oligodendroglioma-derived cells in vitro, without affecting normal cells. Sodium acetate, at doses comparable to that generated by complete GTA catalysis, but not glycerol also promoted growth arrest, whereas long chain triglycerides promoted cell growth. To begin to elucidate its mechanism of action, the effects of GTA on ASPA and acetyl-CoA synthetase protein levels and differentiation of established human oligodendroglioma cells (HOG and Hs683) and primary tumor-derived oligodendroglioma cells that exhibit some features of cancer stem cells (grade II OG33 and grade III OG35) relative to an oligodendrocyte progenitor line (Oli-Neu) were examined. The nuclear localization of ASPA and acetyl-CoA synthetase-1 in untreated cells was regulated during the cell cycle. GTA-mediated growth arrest was not associated with apoptosis or differentiation, but increased expression of acetylated proteins. Thus, GTA-mediated acetate supplementation may provide a safe, novel epigenetic therapy to reduce the growth of oligodendroglioma cells without affecting normal neural stem or oligodendrocyte progenitor cell proliferation or differentiation. PMID:24278309

  17. 77 FR 26048 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-02

    ...--Cape Adare; ASPA 160--Cape Geology; and, ASPA 171--Narebski Point. Access to these sites will be on an... Shirreff; ASPA 150--Ardley Island; ASPA 158--Cape Adare; ASPA 160--Cape Geology; and, ASPA 171-- Narebski...

  18. 75 FR 22433 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... plans to Cape Crozier (ASPA 124), Cape Royds (ASPA 121), Cape Bird, and Beaufort Island (ASPA 105) to study penguins and the effect of age, experience and physiology on individual foraging efficiency and... Crozier (ASPA 124), Cape Royds (ASPA 121), Cape Bird, and Beaufort Island (ASPA 105). Dates: September 1...

  19. 78 FR 24238 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ...-Litchfield Island, ASPA 114-Northern Coronation Island, ASPA 115-Lagotellerie Island, APA 117-Avian Island..., APA 117-Avian Island, ASPA 125-Fildes Peninsula, ASPA 126-Byers Peninsula, ASPA 128-Western Shore of...

  20. 76 FR 49797 - Notice of Permit Modification Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-11

    ..., ASPA 145- Port Foster, Deception Island, APA 150-Ardley Island, and ASPA 152- Western Bransfield Strait...-Port Foster, Deception Island, APA 150-Ardley Island, and ASPA 152-Western Bransfield Strait, and the...

  1. 77 FR 53236 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-31

    ... 154-Botany Bay to conduct a review of their management plans. The Antarctic Support Contract (ASC..., ASPA 137-Northwest White Island, ASPA 138-Linnaeus Terrace, and, ASPA 154-Botany Bay. Dates August 15...

  2. [National socialism health policy and the Aachen region reflected in the "West German Observer"].

    PubMed

    Schreiber, Jürgen; Lohmeier, Jens

    2010-01-01

    The article deals with the question of medicine in the time of the Nazi regime in Germany. It focuses on the question how the media in the "Third Reich" took up the subject "medicine" in general and which aspects were notably mentioned. The footing of this research is the "Westdeutscher Beobachter" and its local edition for the region and the city of Aachen. It was a newspaper published by the regional division of the NSDAP, hence a direct repetition of the Nazi ideology can be expected. During the research it became clear that medicine was not an important subject of propaganda in this newspaper. Only a few articles were about classic Nazi medical topics like "Erbgesundheit" (racial hygiene) and even less about naturopathy. The frequency of articles containing medical issues was very inconsistent, but only in 1934 there was a mentionable number of articles mostly concerning "Erbgesundheit". In this year the racial hygiene poured in law. The main consequence was the forced sterilization of over 300,000 people. Furthermore the topic "medicine" in general seems to be a marginal factor. More popular topics like economic or foreign policy dominated the report of the "Westdeutscher Beobachter". It seems to be that the emphasis was deliberately not laid on the matter "medicine" especially eugenics--which was one of the main components of the Nazi ideology--because the regime didn't want it to become a public interest.

  3. 75 FR 22863 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    .... Applicant: Stevem D. Emslie, Department of Biology and Marine Biology, University of North Carolina... Point, Anvers Island, Palmer Archipelago, ASPA 143-Marine Plain, Mule Peninsula, Vestfold Hills, ASPA...

  4. rAAV Gene Therapy in a Canavan's Disease Mouse Model Reveals Immune Impairments and an Extended Pathology Beyond the Central Nervous System.

    PubMed

    Ahmed, Seemin Seher; Schattgen, Stefan A; Frakes, Ashley E; Sikoglu, Elif M; Su, Qin; Li, Jia; Hampton, Thomas G; Denninger, Andrew R; Kirschner, Daniel A; Kaspar, Brian; Matalon, Reuben; Gao, Guangping

    2016-06-01

    Aspartoacylase (AspA) gene mutations cause the pediatric lethal neurodegenerative Canavan disease (CD). There is emerging promise of successful gene therapy for CD using recombinant adeno-associated viruses (rAAVs). Here, we report an intracerebroventricularly delivered AspA gene therapy regime using three serotypes of rAAVs at a 20-fold reduced dose than previously described in AspA(-/-) mice, a bona-fide mouse model of CD. Interestingly, central nervous system (CNS)-restricted therapy prolonged survival over systemic therapy in CD mice but failed to sustain motor functions seen in systemically treated mice. Importantly, we reveal through histological and functional examination of untreated CD mice that AspA deficiency in peripheral tissues causes morphological and functional abnormalities in this heretofore CNS-defined disorder. We demonstrate for the first time that AspA deficiency, possibly through excessive N-acetyl aspartic acid accumulation, elicits both a peripheral and CNS immune response in CD mice. Our data establish a role for peripheral tissues in CD pathology and serve to aid the development of more efficacious and sustained gene therapy for this disease.

  5. An approach to analyzing a single subject's scores obtained in a standardized test with application to the Aachen Aphasia Test (AAT).

    PubMed

    Willmes, K

    1985-08-01

    Methods for the analysis of a single subject's test profile(s) proposed by Huber (1973) are applied to the Aachen Aphasia Test (AAT). The procedures are based on the classical test theory model (Lord & Novick, 1968) and are suited for any (achievement) test with standard norms from a large standardization sample and satisfactory reliability estimates. Two test profiles of a Wernicke's aphasic, obtained before and after a 3-month period of speech therapy, are analyzed using inferential comparisons between (groups of) subtest scores on one test application and between two test administrations for single (groups of) subtests. For each of these comparisons, the two aspects of (i) significant (reliable) differences in performance beyond measurement error and (ii) the diagnostic validity of that difference in the reference population of aphasic patients are assessed. Significant differences between standardized subtest scores and a remarkably better preserved reading and writing ability could be found for both test administrations using the multiple test procedure of Holm (1979). Comparison of both profiles revealed an overall increase in performance for each subtest as well as changes in level of performance relations between pairs of subtests.

  6. Attenuated enzootic (pestoides) isolates of Yersinia pestis express active aspartase.

    PubMed

    Bearden, Scott W; Sexton, Christopher; Pare, Joshua; Fowler, Janet M; Arvidson, Cindy G; Yerman, Lyudmyla; Viola, Ronald E; Brubaker, Robert R

    2009-01-01

    It is established that Yersinia pestis, the causative agent of bubonic plague, recently evolved from enteropathogenic Yersinia pseudotuberculosis by undergoing chromosomal degeneration while acquiring two unique plasmids that facilitate tissue invasion (pPCP) and dissemination by fleabite (pMT). Thereafter, plague bacilli spread from central Asia to sylvatic foci throughout the world. These epidemic isolates exhibit a broad host range including man as opposed to enzootic (pestoides) variants that remain in ancient reservoirs where infection is limited to muroid rodents. Cells of Y. pseudotuberculosis are known to express glucose-6-phosphate dehydrogenase (Zwf) and aspartase (AspA); these activities are not detectable in epidemic Y. pestis due to missense mutations (substitution of proline for serine at amino position 155 of Zwf and leucine for valine at position 363 of AspA). In this study, functional Zwf was found in pestoides strains E, F and G but not seven other enzootic isolates; enzymic activity was associated with retention of serine at amino acid position 155. Essentially, full AspA activity occurred in pestoides isolates where valine (pestoides A, B, C and D) or serine (pestoides E, F, G and I) occupied position 363. Reduced activity occurred in strains Angola and A16, which contained phenylalanine at this position. The kcat but not Km of purified AspA from strain Angola was significantly reduced. In this context, aspA of the recently described attenuated enzootic microtus biovar encodes active valine at position 363, further indicating that functional AspA is a biomarker for avirulence of Y. pestis in man.

  7. Assessing the effectiveness of specially protected areas for conservation of Antarctica's botanical diversity.

    PubMed

    Hughes, Kevin A; Ireland, Louise C; Convey, Peter; Fleming, Andrew H

    2016-02-01

    Vegetation is sparsely distributed over Antarctica's ice-free ground, and distinct plant communities are present in each of the continent's 15 recently identified Antarctic Conservation Biogeographic Regions (ACBRs). With rapidly increasing human activity in Antarctica, terrestrial plant communities are at risk of damage or destruction by trampling, overland transport, and infrastructure construction and from the impacts of anthropogenically introduced species, as well as uncontrollable pressures such as fur seal (Arctocephalus gazella) activity and climate change. Under the Protocol on Environmental Protection to the Antarctic Treaty, the conservation of plant communities can be enacted and facilitated through the designation of Antarctic Specially Protected Areas (ASPAs). We examined the distribution within the 15 ACBRs of the 33 ASPAs whose explicit purpose includes protecting macroscopic terrestrial flora. We completed the first survey using normalized difference vegetation index (NDVI) satellite remote sensing to provide baseline data on the extent of vegetation cover in all ASPAs designated for plant protection in Antarctica. Large omissions in the protection of Antarctic botanical diversity were found. There was no protection of plant communities in 6 ACBRs, and in another 6, <0.4% of the ACBR area was included in an ASPA that protected vegetation. Protected vegetation cover within the 33 ASPAs totaled 16.1 km(2) for the entire Antarctic continent; over half was within a single protected area. Over 96% of the protected vegetation was contained in 2 ACBRs, which together contributed only 7.8% of the continent's ice-free ground. We conclude that Antarctic botanical diversity is clearly inadequately protected and call for systematic designation of ASPAs protecting plant communities by the Antarctic Treaty Consultative Parties, the members of the governing body of the continent. © 2015 The Authors. Conservation Biology published by Wiley Periodicals, Inc. on

  8. N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells.

    PubMed

    Long, Patrick M; Moffett, John R; Namboodiri, Aryan M A; Viapiano, Mariano S; Lawler, Sean E; Jaworski, Diane M

    2013-09-06

    Metabolic reprogramming is a pathological feature of cancer and a driver of tumor cell transformation. N-Acetylaspartate (NAA) is one of the most abundant amino acid derivatives in the brain and serves as a source of metabolic acetate for oligodendrocyte myelination and protein/histone acetylation or a precursor for the synthesis of the neurotransmitter N-acetylaspartylglutamate (NAAG). NAA and NAAG as well as aspartoacylase (ASPA), the enzyme responsible for NAA degradation, are significantly reduced in glioma tumors, suggesting a possible role for decreased acetate metabolism in tumorigenesis. This study sought to examine the effects of NAA and NAAG on primary tumor-derived glioma stem-like cells (GSCs) from oligodendroglioma as well as proneural and mesenchymal glioblastoma, relative to oligodendrocyte progenitor cells (Oli-Neu). Although the NAA dicarboxylate transporter NaDC3 is primarily thought to be expressed by astrocytes, all cell lines expressed NaDC3 and, thus, are capable of NAA up-take. Treatment with NAA or NAAG significantly increased GSC growth and suppressed differentiation of Oli-Neu cells and proneural GSCs. Interestingly, ASPA was expressed in both the cytosol and nuclei of GSCs and exhibited greatest nuclear immunoreactivity in differentiation-resistant GSCs. Both NAA and NAAG elicited the expression of a novel immunoreactive ASPA species in select GSC nuclei, suggesting differential ASPA regulation in response to these metabolites. Therefore, this study highlights a potential role for nuclear ASPA expression in GSC malignancy and suggests that the use of NAA or NAAG is not an appropriate therapeutic approach to increase acetate bioavailability in glioma. Thus, an alternative acetate source is required.

  9. The plurennial life cycles of the European Tettigoniidae (Insecta: Orthoptera) : 2. The effect of photoperiod on the induction of an initial diapause.

    PubMed

    Ingrisch, Sigfrid

    1986-11-01

    In eggs of European Tettigoniidae species, an initial diapause can occur just after blastoderm formation and a final diapause close to the end of embryonic development. The effect of photoperiod experienced maternally on the induction of the initial diapause was studied, using 13 species from Central and Southeastern Europe. In Conocephalus dorsalis and Platycleis albopunctata there was no initial diapause induced by photoperod, while, in Tettigonia-and Saga-species and in Metrioptera saussuriana it occurred independently of day length. In Metrioptera roeseli, M. bicolor, Leptophyes punctatissima, Eupholidoptera smyrnensis, and Decticus verrucivorus, oviposition at short day induced an initial diapause, while after oviposition at long day, the eggs developed directly until final diapause. On the other hand, in up to 1/4 of the eggs of Pholidoptera griseoaptera an initial diapause was induced by long day length. Populations of D. verrucivorus from different latitudes differed with respect to the critical day length. For E. smyrnensis and M. roeseli, a photoperiodic response curve was calculated.In the Rhodian population of E. smyrnensis, the dormancy sequence of initial and final embryonic diapause can be used for aestivation and hibernation within an annual life cycle, while enabling hibernation in successive years for the Central European species. The population of D. verrucivorus near Aachen has an "obligatory" plurennial life cycle, since the critical day length for development without initial diapause is above the range of day length occurring in the field.

  10. N-Acetylaspartate (NAA) and N-Acetylaspartylglutamate (NAAG) Promote Growth and Inhibit Differentiation of Glioma Stem-like Cells*

    PubMed Central

    Long, Patrick M.; Moffett, John R.; Namboodiri, Aryan M. A.; Viapiano, Mariano S.; Lawler, Sean E.; Jaworski, Diane M.

    2013-01-01

    Metabolic reprogramming is a pathological feature of cancer and a driver of tumor cell transformation. N-Acetylaspartate (NAA) is one of the most abundant amino acid derivatives in the brain and serves as a source of metabolic acetate for oligodendrocyte myelination and protein/histone acetylation or a precursor for the synthesis of the neurotransmitter N-acetylaspartylglutamate (NAAG). NAA and NAAG as well as aspartoacylase (ASPA), the enzyme responsible for NAA degradation, are significantly reduced in glioma tumors, suggesting a possible role for decreased acetate metabolism in tumorigenesis. This study sought to examine the effects of NAA and NAAG on primary tumor-derived glioma stem-like cells (GSCs) from oligodendroglioma as well as proneural and mesenchymal glioblastoma, relative to oligodendrocyte progenitor cells (Oli-Neu). Although the NAA dicarboxylate transporter NaDC3 is primarily thought to be expressed by astrocytes, all cell lines expressed NaDC3 and, thus, are capable of NAA up-take. Treatment with NAA or NAAG significantly increased GSC growth and suppressed differentiation of Oli-Neu cells and proneural GSCs. Interestingly, ASPA was expressed in both the cytosol and nuclei of GSCs and exhibited greatest nuclear immunoreactivity in differentiation-resistant GSCs. Both NAA and NAAG elicited the expression of a novel immunoreactive ASPA species in select GSC nuclei, suggesting differential ASPA regulation in response to these metabolites. Therefore, this study highlights a potential role for nuclear ASPA expression in GSC malignancy and suggests that the use of NAA or NAAG is not an appropriate therapeutic approach to increase acetate bioavailability in glioma. Thus, an alternative acetate source is required. PMID:23884408

  11. Transcriptional regulation of N-acetylaspartate metabolism in the 5xFAD model of Alzheimer's disease: evidence for neuron-glia communication during energetic crisis.

    PubMed

    Zaroff, Samantha; Leone, Paola; Markov, Vladimir; Francis, Jeremy S

    2015-03-01

    N-acetylaspartate (NAA) provides a non-invasive clinical index of neuronal metabolic integrity across the entire neurodegenerative spectrum. While NAA function is not comprehensively defined, reductions in the brain are associated with compromised mitochondrial metabolism and are tightly linked to ATP. We have undertaken an analysis of abnormalities in NAA during early stage pathology in the 5xFAD mouse model of familial Alzheimer's disease and show here that dysregulated expression of the gene encoding for the rate-limiting NAA synthetic enzyme (Nat8L) is associated with deficits in mitochondrial oxidative phosphorylation in this model system. Downreguation of Nat8L is particularly pronounced in the 5xFAD hippocampus, and is preceded by a significant upregulation of oligodendrocytic aspartoacylase (aspa), which encodes for the sole known NAA-catabolizing enzyme in the brain. Reductions in 5xFAD NAA and Nat8L cannot be accounted for by discrepancies in either neuron content or activity of the substrate-providing malate-aspartate shuttle, thereby implicating transcriptional regulation in a coordinated response to pathological energetic crisis. A central role for ASPA in this response is supported by a parallel developmental analysis showing highly significant increases in Nat8L expression in an ASPA-null mouse model during a period of early postnatal development normally punctuated by the transcriptional upregulation of aspa. These results provide preliminary evidence of a signaling mechanism in Alzheimer's disease that involves cross talk between neurons and oligodendrocytes, and suggest that ASPA acts to negatively regulate Nat8L expression. This mechanism is proposed to be a fundamental means by which the brain conserves available substrate during energy crises. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Metabolic Acetate Therapy Improves Phenotype in the Tremor Rat Model of Canavan Disease

    DTIC Science & Technology

    2010-05-13

    treated and untreated female tremor rats (pɘ.05). PA Phosphatidic acid , PC phosphatidylcholine, SM sphingomyelin, PI phosphatidylinositol, PE...was used to confirm the ASPA-deficient phenotype of homozygous tremor rats. The ASPA antibodies were generated against an 18 amino acid sequence from... acid ; 40:50:2:0.2 v/v) solvent front advanced 2/3rds plate height and dried. Solvent system 2 (diethyl ether: hexane; 6:94 v/v) was run the full plate

  13. Canavan disease: an Arab scenario.

    PubMed

    Zayed, Hatem

    2015-04-10

    The autosomal recessive Canavan disease (CD) is a neurological disorder that begins in infancy. CD is caused by mutations in the gene encoding the ASPA enzyme. It has been reported with high frequency in patients with Jewish ancestry, and with low frequency in non-Jewish patients. This review will shed light on some updates regarding CD prevalence and causative mutations across the Arab World. CD was reported in several Arab countries such as Saudi Arabia, Egypt, Jordan, Yemen, Kuwait, and Tunisia. The population with the highest risk is in Saudi Arabia due the prevalent consanguineous marriage culture. In several studies, four novel mutations were found among Arabian CD patients, including two missense mutations (p.C152R, p.C152W), a 3346bp deletion leading to the removal of exon 3 of the ASPA gene, and an insertion mutation (698insC). Other previously reported mutations, which led to damage in the ASPA enzyme activities found among CD Arab patients are c.530 T>C (p.I177T), c.79G>A (p.G27R), IVS4+1G>T, and a 92kb deletion, which is 7.16kb upstream from the ASPA start site. This review will help in developing customized molecular diagnostic approaches and promoting CD carrier screening in the Arab world in areas where consanguineous marriage is common particularly within Saudi Arabia. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. The Engineering Design of Engine/Airframe Integration for the SAENGER Fully Reusable Space Transportation System

    DTIC Science & Technology

    2010-09-01

    1995 Dasa-DA Hot Metallic Structure Dasa-LM Raufoss A/S (N) NBL Partner Plansee (A) *) HTP, initiated 1988 and sponsored by the German Federal Ministry...Dornier NBL Partner TsAGI (Gus) VOLVO (S) CIAM (GUS) NBL Partner VOLVO (S) AEDC (US) VOLVO (S) Dasa-RI Dasa-LM TU Stuttgart RWTH Aachen DLR TsAGI (GUS

  15. The Aachen Mobility and Balance Index to measure physiological falls risk: a comparison with the Tinetti POMA Scale.

    PubMed

    Knobe, M; Giesen, M; Plate, S; Gradl-Dietsch, G; Buecking, B; Eschbach, D; van Laack, W; Pape, H-C

    2016-10-01

    The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale. For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland-Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated. The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = -0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of

  16. 75 FR 26287 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... understand the implications of future climate changes. Location Canada Glacier (ASPA 131), Taylor Dry Valley..., Natural Resource Ecology Laboratory, Colorado State University, 200 West Lake, Fort Collins, CO 80523-1499...

  17. [Intensive care medicine as a component of the compulsory medical curriculum. Evaluation of a pilot curriculum at the University Hospital Aachen].

    PubMed

    Beckers, S K; Rex, S; Kopp, R; Bickenbach, J; Sopka, S; Rossaint, R; Dembinski, R

    2009-03-01

    In order to provide early achievement of practical experience during medical education, the medical faculty of the university Aachen has developed a new medical school curriculum which was offered in 2003 for the first time. In this curriculum anaesthesiology became a compulsory subject with practical training both in the operation theatre and in emergency medicine. Accordingly, a practical course in the field of intensive care medicine has also been designed with respect to the planned schedule and personnel resources. This course was evaluated by both students and teaching staff in a written, anonymous form as a quality control. A dedicated course was developed for medical students of the 8th and 9th semesters. In this course comprised of 6 students and lasting 1 week, practical training is provided by intensive care physicians and accompanied by theoretical lessons focusing on the definition, diagnosis, therapy and prophylaxis of sepsis, essentials of mechanical ventilation and patient presentation at the bedside during daily rounds. On the last day of training students were required to present patients by themselves thereby recapitulating the acquired knowledge. In the summer semester 2007 this intensive care training course was offered for the first time. All participating 83 students and 23 physicians involved in teaching evaluated the course with marks from 1 to 6 according to the standard German school grading system using an online questionnaire. Students rated the course with 1.6+/-0.7 (mean +/- SD) for comprehensibility, with 1.6+/-0.7 for structural design, and with 1.7+/-0.7 for agreement between teachers. They graded their personal learning success with 1.7+/-0.7. With a cumulative mark of 1.7+/-0.6, the course was ranked as 1 of the top 3 courses of the medical faculty from the very beginning. The majority of the teaching staff (80%) appreciated the focus on few selected teaching subjects. However, comprehensibility, structural design, agreement

  18. 78 FR 56744 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-13

    ... (ASMA 7). All materials collected would be salvaged; the applicant would not interact with live animals... birds and mammals. Location ASPA 149 Cape Shireff and ASMA 7 Southwest Anvers Island (Palmer Station...

  19. Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages

    PubMed Central

    Schumacher, Maria A.; Tonthat, Nam K; Lee, Jeehyun; Rodriguez-Castañeda, Fernando A.; Chinnam, Naga babu; Kalliomaa-Sanford, Anne K.; Ng, Irene W.; Barge, Madhuri T.; Shaw, Porsha L.R.; Barillà, Daniela

    2016-01-01

    Although recent studies have provided a wealth of information about archaeal biology, nothing is known about the molecular basis of DNA segregation in these organisms. Here we unveil the machinery and assembly mechanism of the archaeal Sulfolobus pNOB8 partition system. This system employs three proteins; ParA, an atypical ParB adaptor and a centromere-binding component, AspA. AspA utilizes a spreading mechanism to create a DNA superhelix onto which ParB assembles. This supercomplex links to the ParA motor, which contains a bacteria-like Walker motif. The ParB C-domain harbors structural similarity to CenpA, which dictates eukaryotic segregation. Thus, this archaeal system combines bacteria-like and eukarya-like components, suggesting the possible conservation of DNA segregation principles across the three domains of life. PMID:26339031

  20. 78 FR 52804 - Notice of Permit Applications Received Under the Antarctic Conservation Act of 1978 (Pub. L. 95-541)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-26

    ... escort is cognizant of--and will follow the requirements contained in--the ASPA management plans and the...'' documentary procedures with regard to the natural environment as well as to adhere to all USAP operations and...

  1. Defeating Adversary Network Intelligence Efforts with Active Cyber Defense Techniques

    DTIC Science & Technology

    2008-06-01

    Hide Things from Hackers: Processes, Principles, and Techniques,” Journal of Information Warfare , 5 (3): 26-40 (2006). 20. Rosenau, William ...54 Additional Sources Apel , Thomas. Generating Fingerprints of Network Servers and their Use in Honeypots. Thesis. Aachen University, Aachen...Paul Williams , PhD (ENG) REPORT U ABSTRACT U c. THIS PAGE U 17. LIMITATION OF ABSTRACT UU 18. NUMBER OF PAGES 55

  2. Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages.

    PubMed

    Schumacher, Maria A; Tonthat, Nam K; Lee, Jeehyun; Rodriguez-Castañeda, Fernando A; Chinnam, Naga Babu; Kalliomaa-Sanford, Anne K; Ng, Irene W; Barge, Madhuri T; Shaw, Porsha L R; Barillà, Daniela

    2015-09-04

    Although recent studies have provided a wealth of information about archaeal biology, nothing is known about the molecular basis of DNA segregation in these organisms. Here, we unveil the machinery and assembly mechanism of the archaeal Sulfolobus pNOB8 partition system. This system uses three proteins: ParA; an atypical ParB adaptor; and a centromere-binding component, AspA. AspA utilizes a spreading mechanism to create a DNA superhelix onto which ParB assembles. This supercomplex links to the ParA motor, which contains a bacteria-like Walker motif. The C domain of ParB harbors structural similarity to CenpA, which dictates eukaryotic segregation. Thus, this archaeal system combines bacteria-like and eukarya-like components, which suggests the possible conservation of DNA segregation principles across the three domains of life. Copyright © 2015, American Association for the Advancement of Science.

  3. 77 FR 5403 - Conservation of Antarctic Animals and Plants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-03

    ... Antarctic Specially Protected Areas (ASPA), Antarctic Specially Managed Areas (ASMA) and Historical Sites or... managed area (ASMA 7) and five historical sites and monuments in Antarctica (HSM 83-87). Public... Antarctic Specially Managed Areas (ASMA). Detailed maps and descriptions of the sites and complete...

  4. An Iterative, Bimodular Nonribosomal Peptide Synthetase that Converts Anthranilate and Tryptophan into Tetracyclic Asperlicins

    PubMed Central

    Gao, Xue; Jiang, Wei; Jiménez-Osés, Gonzalo; Choi, Moon Seok; Houk, Kendall N.; Tang, Yi; Walsh, Christopher T.

    2013-01-01

    The bimodular 276 kDa nonribosomal peptide synthetase AspA from Aspergillus alliaceus, heterologously expressed in Saccharomyces cerevisiae, converts tryptophan and two molecules of the aromatic β-amino acid anthranilate (Ant) into a pair of tetracyclic peptidyl alkaloids asperlicin C and D in a ratio of 10:1. The first module of AspA activates and processes two molecules of Ant iteratively to generate a tethered Ant-Ant-Trp-S-enzyme intermediate on module two. Release is postulated to involve tandem cyclizations, in which the first step is the macrocyclization of the linear tripeptidyl-S-enzyme, by the terminal condensation (CT) domain to generate the regioisomeric tetracyclic asperlicin scaffolds. Computational analysis of the transannular cyclization of the 11-membered macrocyclic intermediate shows that asperlicin C is the kinetically favored product due to the high stability of a conformation resembling the transition state for cyclization, while asperlicin D is thermodynamically more stable. PMID:23890005

  5. Evaluation of a Glass Ionomer Restoration to Treat Hypersensitive Cervical Anatomic Deficiencies.

    DTIC Science & Technology

    1983-03-01

    glass ionomer cement to existing dental cements such as...that the milder pulp reaction to a glass ionomer cement as opposed to a phosphoric acid cement may be explained by the weaker acid makeup of the ASPA...7 Sensitivity Evaluation ........................... 9 Treatment of Dentinal Sensitivity................. 12 Glass Ionomer Cements

  6. Evaluation of the utility and energy monitoring and control system installed at the US Army, Europe, 409th Base Support Battalion, Military Community at Grafenwoehr, Germany

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Broders, M.A.; Ruppel, F.R.

    1993-05-01

    Under the provisions of Interagency Agreement DOE 1938-B090-A1 between the US Department of Energy (DOE) and the US Army Europe (USAREUR), Martin Marietta Energy Systems, Inc., is providing technical assistance to USAREUR in the areas of computer science, information engineering, energy studies, and engineering and systems development. One of the initial projects authorized under this interagency agreement is the evaluation of utility and energy monitoring and control systems (UEMCSs) installed at selected US Army installations in Europe. This report is an evaluation of the overall energy-conservation effectiveness and use of the UEMCS at the 409th Base Support Battalion located inmore » Grafenwoehr, Germany. The 409th Base Support Battalion is a large USAREUR military training facility that comprises a large training area, leased housing, the main post area, and the camp areas that include Camps Aachen, Algier, Normandy, Cheb, and Kasserine. All of these facilities are consumers of electrical and thermal energy. However, only buildings and facilities in the main post area and Camps Aachen, Algier, and Normandy are under the control of the UEMCS. The focus of this evaluation report is on these specific areas. Recommendations to further increase energy and cost savings and to improve operation of the UEMCS are proposed.« less

  7. The Effects of Autonomy Support on Student Engagement in Peer Assessment

    ERIC Educational Resources Information Center

    Yuan, Jiangmei; Kim, ChanMin

    2018-01-01

    Although peer assessment is widely implemented in higher education, not all students are highly engaged in it. To enhance student engagement in peer assessment, we designed and developed a web-based tool, autonomy-supportive peer assessment (ASPA), to support students' need for autonomy when they conducted peer assessment. Students' sense of…

  8. Rudolf Hermann, wind tunnels and aerodynamics

    NASA Astrophysics Data System (ADS)

    Lundquist, Charles A.; Coleman, Anne M.

    2008-04-01

    Rudolf Hermann was born on December 15, 1904 in Leipzig, Germany. He studied at the University of Leipzig and at the Aachen Institute of Technology. His involvement with wind tunnels began in 1934 when Professor Carl Wieselsberger engaged him to work at Aachen on the development of a supersonic wind tunnel. On January 6, 1936, Dr. Wernher von Braun visited Dr. Hermann to arrange for use of the Aachen supersonic wind tunnel for Army problems. On April 1, 1937, Dr. Hermann became Director of the Supersonic Wind Tunnel at the Army installation at Peenemunde. Results from the Aachen and Peenemunde wind tunnels were crucial in achieving aerodynamic stability for the A-4 rocket, later designated as the V-2. Plans to build a Mach 10 'hypersonic' wind tunnel facility at Kochel were accelerated after the Allied air raid on Peenemunde on August 17, 1943. Dr. Hermann was director of the new facility. Ignoring destruction orders from Hitler as WWII approached an end in Europe, Dr. Hermann and his associates hid documents and preserved wind tunnel components that were acquired by the advancing American forces. Dr. Hermann became a consultant to the Air Force at its Wright Field in November 1945. In 1951, he was named professor of Aeronautical Engineering at the University of Minnesota. In 1962, Dr. Hermann became the first Director of the Research Institute at the University of Alabama in Huntsville (UAH), a position he held until he retired in 1970.

  9. A Decade of Development: The Best of Ten Years. An Anniversary Publication of Selected Papers. Adult Student Personnel Association, Inc.

    ERIC Educational Resources Information Center

    Clifford, Earle W., Ed.; And Others

    "The Best of Ten Years," a publication of the Tenth Annual Conference for the Adult Student Personnel Association, Inc. (ASPA), contains prophesies for the future in addition to a chronicle of concerns of the decade. Articles included are: Financial Aid for Evening Students (Sol Jacobson); The Programming and Counseling of Adult Transfer Students…

  10. The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence.

    PubMed

    Vargas-Muñiz, José M; Renshaw, Hilary; Richards, Amber D; Lamoth, Frédéric; Soderblom, Erik J; Moseley, M Arthur; Juvvadi, Praveen R; Steinbach, William J

    2015-08-01

    Septins are a conserved family of GTPases that regulate important cellular processes such as cell wall integrity, and septation in fungi. The requirement of septins for virulence has been demonstrated in the human pathogenic yeasts Candida albicans and Cryptococcus neoformans, as well as the plant pathogen Magnaporthe oryzae. Aspergillus spp. contains five genes encoding for septins (aspA-E). While the importance of septins AspA, AspB, AspC, and AspE for growth and conidiation has been elucidated in the filamentous fungal model Aspergillus nidulans, nothing is known on the role of septins in growth and virulence in the human pathogen Aspergillus fumigatus. Here we deleted all five A. fumigatus septins, and generated certain double and triple septin deletion strains. Phenotypic analyses revealed that while all the septins are dispensable in normal growth conditions, AspA, AspB, AspC and AspE are required for regular septation. Furthermore, deletion of only the core septin genes significantly reduced conidiation. Concomitant with the absence of an electron-dense outer conidial wall, the ΔaspB strain was also sensitive to anti-cell wall agents. Infection with the ΔaspB strain in a Galleria mellonella model of invasive aspergillosis showed hypervirulence, but no virulence difference was noted when compared to the wild-type strain in a murine model of invasive aspergillosis. Although the deletion of aspB resulted in increased release of TNF-α from the macrophages, no significant inflammation differences in lung histology was noted between the ΔaspB strain and the wild-type strain. Taken together, these results point to the importance of septins in A. fumigatus growth, but not virulence in a murine model. Copyright © 2015 Elsevier Inc. All rights reserved.

  11. HHS Archive Home Page

    Science.gov Websites

    Health and Human Service staff. HHS Blog Exit Disclaimer This collection includes HHS blog posts Safety Working Group* Indian Health Service (IHS) Indian Health Service* National Institutes of Health )* HealthIT.gov (ONC)* Office of Minority Health (ASH)* Public Health Emergency (ASPR)* Stopbullying.gov (ASPA

  12. The Molecular Basis of Canavan Disease: Aspartoacylase Enzyme Characteristics

    DTIC Science & Technology

    2006-01-01

    this conclusion by observing that children with certain neurodegenerative conditions also had N-acetylaspartic aciduria , abnormally high levels of NAA...in the urine. In the late 1980’s, N-acetylaspartic aciduria and deficient ASPA activity in cultured fibroblasts were linked to cases of cerebral...symptoms of CD are found in other leukodystrophies and neurodegenerative disorders, N-acetylaspartic aciduria is exclusive to CD. Slightly elevated

  13. Knowledge Acquisition: A Review of Tools and Ideas.

    DTIC Science & Technology

    1987-08-01

    tools. However, none could be applied directly to solving the problem of acquiring knowledge for the ASPA. RECOMMENDATIONS Develop a tool based on...the social sciences. BACKGROUND Because of the newness and complexity of the knowledge acquisition problem, the background of the knowledge...4. Minimal (does not incorporate any unnecessary complexities ) 5. Expected (experts are not in disagreement over any important aspect) (Grover 1983

  14. N-Acetylaspartate in the CNS: From Neurodiagnostics to Neurobiology

    PubMed Central

    Moffett, John R.; Ross, Brian; Arun, Peethambaran; Madhavarao, Chikkathur N.; Namboodiri, M. A. A.

    2007-01-01

    The brain is unique among organs in many respects, including its mechanisms of lipid synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate (NAA), which is synthesized from aspartate and acetyl-coenzyme A in neurons, appears to be a key link in these distinct biochemical features of CNS metabolism. During early postnatal CNS development, the expression of lipogenic enzymes in oligodendrocytes, including the NAA-degrading enzyme aspartoacylase (ASPA), is increased along with increased NAA production in neurons. NAA is transported from neurons to the cytoplasm of oligodendrocytes, where ASPA cleaves the acetate moiety for use in fatty acid and steroid synthesis. The fatty acids and steroids produced then go on to be used as building blocks for myelin lipid synthesis. Mutations in the gene for ASPA result in the fatal leukodystrophy Canavan disease, for which there is currently no effective treatment. Once postnatal myelination is completed, NAA may continue to be involved in myelin lipid turnover in adults, but it also appears to adopt other roles, including a bioenergetic role in neuronal mitochondria. NAA and ATP metabolism appear to be linked indirectly, whereby acetylation of aspartate may facilitate its removal from neuronal mitochondria, thus favoring conversion of glutamate to alpha ketoglutarate which can enter the tricarboxylic acid cycle for energy production. In its role as a mechanism for enhancing mitochondrial energy production from glutamate, NAA is in a key position to act as a magnetic resonance spectroscopy marker for neuronal health, viability and number. Evidence suggests that NAA is a direct precursor for the enzymatic synthesis of the neuron specific dipeptide N-acetylaspartylglutamate, the most concentrated neuropeptide in the human brain. Other proposed roles for NAA include neuronal osmoregulation and axon-glial signaling. We propose that NAA may also be involved in brain nitrogen balance. Further research

  15. Integrated image data and medical record management for rare disease registries. A general framework and its instantiation to theGerman Calciphylaxis Registry.

    PubMed

    Deserno, Thomas M; Haak, Daniel; Brandenburg, Vincent; Deserno, Verena; Classen, Christoph; Specht, Paula

    2014-12-01

    Especially for investigator-initiated research at universities and academic institutions, Internet-based rare disease registries (RDR) are required that integrate electronic data capture (EDC) with automatic image analysis or manual image annotation. We propose a modular framework merging alpha-numerical and binary data capture. In concordance with the Office of Rare Diseases Research recommendations, a requirement analysis was performed based on several RDR databases currently hosted at Uniklinik RWTH Aachen, Germany. With respect to the study management tool that is already successfully operating at the Clinical Trial Center Aachen, the Google Web Toolkit was chosen with Hibernate and Gilead connecting a MySQL database management system. Image and signal data integration and processing is supported by Apache Commons FileUpload-Library and ImageJ-based Java code, respectively. As a proof of concept, the framework is instantiated to the German Calciphylaxis Registry. The framework is composed of five mandatory core modules: (1) Data Core, (2) EDC, (3) Access Control, (4) Audit Trail, and (5) Terminology as well as six optional modules: (6) Binary Large Object (BLOB), (7) BLOB Analysis, (8) Standard Operation Procedure, (9) Communication, (10) Pseudonymization, and (11) Biorepository. Modules 1-7 are implemented in the German Calciphylaxis Registry. The proposed RDR framework is easily instantiated and directly integrates image management and analysis. As open source software, it may assist improved data collection and analysis of rare diseases in near future.

  16. Initiation devices, initiation systems including initiation devices and related methods

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Daniels, Michael A.; Condit, Reston A.; Rasmussen, Nikki

    Initiation devices may include at least one substrate, an initiation element positioned on a first side of the at least one substrate, and a spark gap electrically coupled to the initiation element and positioned on a second side of the at least one substrate. Initiation devices may include a plurality of substrates where at least one substrate of the plurality of substrates is electrically connected to at least one adjacent substrate of the plurality of substrates with at least one via extending through the at least one substrate. Initiation systems may include such initiation devices. Methods of igniting energetic materialsmore » include passing a current through a spark gap formed on at least one substrate of the initiation device, passing the current through at least one via formed through the at least one substrate, and passing the current through an explosive bridge wire of the initiation device.« less

  17. The International Criminal Court: Time to Adjust American Foreign Policy

    DTIC Science & Technology

    2009-05-26

    million Cambodians , this slaughter, to some, is not genocide because it was based on politically- divided groups and not based on reasons due to...the Crime of Genocide , essentially establishing the international crime of genocide . The Convention dictated that genocide must be tried by the State in... genocide , and crimes against humanity.29 On 1 July 2003, the Bush Administration invoked one of the provisions of the ASPA and terminated military assistance

  18. Glass ionomer cements: chemistry of erosion.

    PubMed

    Crisp, S; Lewis, B G; Wilson, A D

    1976-01-01

    A three-month study of the chemistry of the water erosion of two forms of ASPA cement has been made. The effect of varying cement consistency and cure time was investigated. The results are discussed in terms of the known chemistry and structure of the cement. The erosion behavior is compared to that of silicate, silicophosphate, and zinc polycarboxylate dental cements. The state of absorbed water and the mechanism of erosion is discussed.

  19. Calibration results using highly aberrated images for aligning the JWST instruments to the telescope

    NASA Astrophysics Data System (ADS)

    Smith, Koby Z.; Acton, D. Scott; Gallagher, Ben B.; Knight, J. Scott; Dean, Bruce H.; Jurling, Alden S.; Zielinski, Thomas P.

    2016-07-01

    The James Webb Space Telescope (JWST) project is an international collaboration led by NASA's Goddard Space Flight Center (GSFC) in Greenbelt, MD. JWST is NASA's flagship observatory that will operate nearly a million miles away from Earth at the L2 Lagrange point. JWST's optical design is a three-mirror anastigmat with four main optical components; 1) the eighteen Primary Mirror Segment Assemblies (PMSA), 2) a single Secondary Mirror Assembly (SMA), 3) an Aft-Optics Subsystem (AOS) consisting of a Tertiary Mirror and Fine Steering Mirror, and 4) an Integrated Science Instrument Module consisting of the various instruments for JWST. JWST's optical system has been designed to accommodate a significant amount of alignment capability and risk with the PMSAs and SMA having rigid body motion available on-orbit just for alignment purposes. However, the Aft-Optics Subsystem (AOS) and Integrated Science Instrument Module (ISIM) are essentially fixed optical subsystems within JWST, and therefore the cryogenic alignment of the AOS to the ISIM is critical to the optical performance and mission success of JWST. In support of this cryogenic alignment of the AOS to ISIM, an array of fiber optic sources, known as the AOS Source Plate Assembly (ASPA), are placed near the intermediate image location of JWST (between the secondary and tertiary mirrors) during thermal vacuum ground-test operations. The AOS produces images of the ASPA fiber optic sources at the JWST focal surface location, where they are captured by the various science instruments. In this manner, the AOS provides an optical yardstick by which the instruments within ISIM can evaluate their relative positions to and the alignment of the AOS to ISIM can be quantified. However, since the ASPA is located at the intermediate image location of the JWST three-mirror anastigmat design, the images of these fiber optic sources produced by the AOS are highly aberrated with approximately 2-3μm RMS wavefront error consisting

  20. Materials Research Society, Symposium Proceedings, Volume 521. Porous and Cellular Materials for Structural Applications

    DTIC Science & Technology

    1998-04-15

    UTRC GmbH, Technologiezentrum, Am Europaplatz, D-52068 Aachen, Germany. SaenzE@ctaero.com **UTRC, S.L. c/o CTA Parque Tecnologico de...Alava. 01510 Mifiano (Alava). Spain. barandap @ eng 1 .otis .com ***ITMA, Parque Tecnologico de Asturias, 33 428 Corufio-Llanera, Spain

  1. Towards Clean Diesel Engines. Second Symposium. Book of Abstracts.

    DTIC Science & Technology

    1998-04-06

    and Mie-scattering imaging and EXCIPLEX technique, based on a fluorescence system. This last technique, even if it is able to distinguish...set of experimental data, ob- tained by a collaborative effort with researchers at the RWTH Aachen, is presented. Laser-induced exciplex fluorescence

  2. Direct Penguin Counting Using Unmanned Aerial Vehicle Image

    NASA Astrophysics Data System (ADS)

    Hyun, C. U.; Kim, H. C.; Kim, J. H.; Hong, S. G.

    2015-12-01

    This study presents an application of unmanned aerial vehicle (UAV) images to monitor penguin colony in Baton Peninsula, King George Island, Antarctica. The area around Narębski Point located on the southeast coast of Barton Peninsula was designated as Antarctic Specially Protected Area No. 171 (ASPA 171), and Chinstrap and Gentoo penguins inhabit in this area. The UAV images were acquired in a part of ASPA 171 from four flights in a single day, Jan 18, 2014. About 360 images were mosaicked as an image of about 3 cm spatial resolution and then a subset including representative penguin rookeries was selected. The subset image was segmented based on gradient map of pixel values, and spectral and spatial attributes were assigned to each segment. The object based image analysis (OBIA) was conducted with consideration of spectral attributes including mean and minimum values of each segment and various shape attributes such as area, length, compactness and roundness to detect individual penguin. The segments indicating individual penguin were effectively detected on rookeries with high contrasts in the spectral and shape attributes. The importance of periodic and precise monitoring of penguins has been recognized because variations of their populations reflect environmental changes and disturbance from human activities. Utilization of very high resolution imaging method shown in this study can be applied to other penguin habitats in Antarctica, and the results will be able to support establishing effective environmental management plans.

  3. Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Juvvadi, Praveen Rao; Belina, Detti; Soderblom, Erik J.

    2013-02-15

    Highlights: ► In vivo interactions of the novel septin AspE were identified by GFP-Trap® affinity purification. ► Septins AspA, AspB, AspC and AspD interacted with AspE in vivo. ► Actin and tubulin interacted with AspE in vivo. ► AspE is phosphorylated at six serine residues in vivo. -- Abstract: We previously analyzed the differential localization patterns of five septins (AspA–E), including a filamentous fungal-specific septin, AspE, in the human pathogen Aspergillus fumigatus. Here we utilized the A. fumigatus strain expressing an AspE–EGFP fusion protein and show that this novel septin with a tubular localization pattern in hyphae is phosphorylated inmore » vivo and interacts with the other septins, AspA, AspB, AspC and AspD. The other major proteins interacting with AspE included the cytoskeletal proteins, actin and tubulin, which may be involved in the organization and transport of the septins. This is the first report analyzing the phosphorylation of AspE and localizing the sites of phosphorylation, and opens opportunities for further analysis on the role of post-translational modifications in the assembly and organization of A. fumigatus septins. This study also describes the previously unknown interaction of AspE with the actin-microtubule network. Furthermore, the novel GFP-Trap® affinity purification method used here complements widely-used GFP localization studies in fungal systems.« less

  4. [Chemical and Thermal Eye Burns].

    PubMed

    Struck, H-G

    2016-11-01

    Background: This review gives a therapeutic approach for the early treatment of chemical and thermal burns of the ocular surface (CTOS). Method: Based on a review of international literature, the experiences of University Hospital Aachen and Halle/Saale, Eye Clinic Cologne as well as experimental data of the research institute (An-Institut) at RWTH Aachen University are considered and discussed. Results: As the risk depends on the stage of CTOS, recommendations are given for acute treatment for different stages. Pathophysiological considerations will be discussed. Special treatment options for exceptional situations and for late phase CTOS are demonstrated. Conclusion: According to the latest data, the most important clinical recommendation for the acute phase of CTOS is the application of a suitable rinsing solution. Furthermore, anti-inflammatory treatment is of central importance. For the therapy of severe CTOS, approved and advanced surgical methods need to be applied. In this way, anti-inflammatory and tissue-protecting mechanisms are activated simultaneously. Georg Thieme Verlag KG Stuttgart · New York.

  5. Summary of semi-initiative and initiative control automobile engine vibration

    NASA Astrophysics Data System (ADS)

    Qu, Wei; Qu, Zhou

    2009-07-01

    Engine vibration accounts for around 55% of automobile vibration, separating the engine vibration from transmitting to automobile to the utmost extent is significant for improving NVH performance. Semi-initiative and initiative control of engine vibration is one of the hot spots of technical research in domestic and foreign automobile industry, especially luxury automobiles which adopt this technology to improve amenity and competitiveness. This article refers to a large amount of domestic and foreign related materials, fully introduces the research status of semi-initiative and initiative control suspension of engine vibration suspension and many kinds of structural style, and provides control policy and method of semi-initiative and initiative control suspension system. Compare and analyze the structural style of semi-initiative and initiative control and merits and demerits of current structures of semi-initiative and initiative control of mechanic electrorheological, magnetorheological, electromagnetic actuator, piezoelectric ceramics, electrostriction material, pneumatic actuator etc. Models of power assembly mounting system was classified.Calculation example indicated that reasonable selection of engine mounting system parameters is useful to reduce engine vibration transmission and to increase ride comfort. Finally we brought forward semi-initiative and initiative suspension which might be applied for automobiles, and which has a promising future.

  6. Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest.

    PubMed

    Long, Patrick M; Tighe, Scott W; Driscoll, Heather E; Fortner, Karen A; Viapiano, Mariano S; Jaworski, Diane M

    2015-08-01

    Glioblastoma (GBM), the most common primary adult malignant brain tumor, is associated with a poor prognosis due, in part, to tumor recurrence mediated by chemotherapy and radiation resistant glioma stem-like cells (GSCs). The metabolic and epigenetic state of GSCs differs from their non-GSC counterparts, with GSCs exhibiting greater glycolytic metabolism and global hypoacetylation. However, little attention has been focused on the potential use of acetate supplementation as a therapeutic approach. N-acetyl-l-aspartate (NAA), the primary storage form of brain acetate, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis, are significantly reduced in GBM tumors. We recently demonstrated that NAA supplementation is not an appropriate therapeutic approach since it increases GSC proliferation and pursued an alternative acetate source. The FDA approved food additive Triacetin (glyceryl triacetate, GTA) has been safely used for acetate supplementation therapy in Canavan disease, a leukodystrophy due to ASPA mutation. This study characterized the effects of GTA on the proliferation and differentiation of six primary GBM-derived GSCs relative to established U87 and U251 GBM cell lines, normal human cerebral cortical astrocytes, and murine neural stem cells. GTA reduced proliferation of GSCs greater than established GBM lines. Moreover, GTA reduced growth of the more aggressive mesenchymal GSCs greater than proneural GSCs. Although sodium acetate induced a dose-dependent reduction of GSC growth, it also reduced cell viability. GTA-mediated growth inhibition was not associated with differentiation, but increased protein acetylation. These data suggest that GTA-mediated acetate supplementation is a novel therapeutic strategy to inhibit GSC growth. © 2015 Wiley Periodicals, Inc.

  7. Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest

    PubMed Central

    Long, Patrick M.; Tighe, Scott W.; Driscoll, Heather E.; Fortner, Karen A.; Viapiano, Mariano S.; Jaworski, Diane M.

    2015-01-01

    Glioblastoma (GBM), the most common primary adult malignant brain tumor, is associated with a poor prognosis due, in part, to tumor recurrence mediated by chemotherapy and radiation resistant glioma stem-like cells (GSCs). The metabolic and epigenetic state of GSCs differs from their non-GSC counterparts, with GSCs exhibiting greater glycolytic metabolism and global hypoacetylation. However, little attention has been focused on the potential use of acetate supplementation as a therapeutic approach. N-acetyl-L-aspartate (NAA), the primary storage form of brain acetate, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis, are significantly reduced in GBM tumors. We recently demonstrated that NAA supplementation is not an appropriate therapeutic approach since it increases GSC proliferation and pursued an alternative acetate source. The FDA approved food additive Triacetin (glyceryl triacetate, GTA) has been safely used for acetate supplementation therapy in Canavan disease, a leukodystrophy due to ASPA mutation. This study characterized the effects of GTA on the proliferation and differentiation of six primary GBM-derived GSCs relative to established U87 and U251 GBM cell lines, normal human cerebral cortical astrocytes, and murine neural stem cells. GTA reduced proliferation of GSCs greater than established GBM lines. Moreover, GTA reduced growth of the more aggressive mesenchymal GSCs greater than proneural GSCs. Although sodium acetate induced a dose-dependent reduction of GSC growth, it also reduced cell viability. GTA-mediated growth inhibition was not associated with differentiation, but increased protein acetylation. These data suggest that GTA-mediated acetate supplementation is a novel therapeutic strategy to inhibit GSC growth. PMID:25573156

  8. Single-step purification and characterization of recombinant aspartase of Aeromonas media NFB-5.

    PubMed

    Singh, Ram Sarup; Yadav, Mukesh

    2012-07-01

    Aspartase (L-aspartate ammonia-lyase; EC 4.3.1.1) catalyzes the reversible amination of fumaric acid to produce L-aspartic acid. Aspartase coding gene (aspA) of Aeromonas media NFB-5 was cloned, sequenced, and expressed with His tag using pET-21b⁺ expression vector in Escherichia coli BL21. Higher expression was obtained with IPTG (1.5 mM) induction for 5 h at 37 °C in LB medium supplemented with 0.3% K₂HPO₄ and 0.3% KH₂PO₄. Recombinant His tagged aspartase was purified using Ni-NTA affinity chromatography and characterized for various biochemical and kinetic parameters. The purified aspartase showed optimal activity at pH 8.5 and 8.0 in the presence and absence of magnesium ions, respectively. The optimum temperature was determined to be 35 °C. The enzyme showed apparent K(m) and V(max) values for L-aspartate as 2.01 mM and 114 U/mg, respectively. The enzyme was stable in pH range of 6.5-9.5 and temperature up to 45 °C. Divalent metal ion requirement of enzyme was efficiently fulfilled by Mg²⁺, Mn²⁺, and Ca²⁺ ions. The cloned gene (aspA) product showed molecular weight of approximately 51 kDa by SDS-PAGE, which is in agreement with the molecular weight calculated from putative amino acid sequence. This is the first report on expression and characterization of recombinant aspartase from A. media.

  9. The Plus 50 Initiative Evaluation: Initiative Impact

    ERIC Educational Resources Information Center

    American Association of Community Colleges (NJ1), 2012

    2012-01-01

    The American Association of Community Colleges (AACC), with funding from The Atlantic Philanthropies, created the Plus 50 Initiative (2008-2012). This initiative was designed to build the capacity of community colleges nationwide to develop programming that engages the plus 50 learner. This report contains: (1) An overview of the Plus 50…

  10. Initialized Fractional Calculus

    NASA Technical Reports Server (NTRS)

    Lorenzo, Carl F.; Hartley, Tom T.

    2000-01-01

    This paper demonstrates the need for a nonconstant initialization for the fractional calculus and establishes a basic definition set for the initialized fractional differintegral. This definition set allows the formalization of an initialized fractional calculus. Two basis calculi are considered; the Riemann-Liouville and the Grunwald fractional calculi. Two forms of initialization, terminal and side are developed.

  11. Prevalence of Obesity, Binge Eating, and Night Eating in a Cross-Sectional Field Survey of 6-Year-Old Children and Their Parents in a German Urban Population

    ERIC Educational Resources Information Center

    Lamerz, Andreas; Kuepper-Nybelen, Jutta; Bruning, Nicole; Wehle, Christine; Trost-Brinkhues, Gabriele; Brenner, Hermann; Hebebrand, Johannes; Herpertz-Dahlmann, Beate

    2005-01-01

    Background: To assess the prevalence of obesity, obesity-related binge eating, non-obesity-related binge eating, and night eating in five- to six-year-old children and to examine the impact of parental eating disturbances. Methods: When 2020 children attended their obligatory health exam prior to school entry in the city of Aachen, Germany, 1979…

  12. Reduction of initial shock in decadal predictions using a new initialization strategy

    NASA Astrophysics Data System (ADS)

    He, Yujun; Wang, Bin

    2017-04-01

    Initial shock is a well-known problem occurring in the early years of a decadal prediction when assimilating full-field observations into a coupled model, which directly affects the prediction skill. For the purpose to alleviate this problem, we propose a novel full-field initialization method based on dimension-reduced projection four-dimensional variational data assimilation (DRP-4DVar). Different from the available solution strategies including anomaly assimilation and bias correction, it substantially reduces the initial shock through generating more consistent initial conditions for the coupled model, which, along with the model trajectory in one-month windows, best fit the monthly mean analysis data of oceanic temperature and salinity. We evaluate the performance of initialized hindcast experiments according to three proposed indices to measure the intensity of the initial shock. The results indicate that this strategy can obviously reduce the initial shock in decadal predictions by FGOALS-g2 (the Flexible Global Ocean-Atmosphere-Land System model, Grid-point Version 2) compared with the commonly-used nudging full-field initialization for the same model as well as the different full-field initialization strategies for other CMIP5 (the fifth phase of the Coupled Model Intercomparison Project) models whose decadal prediction results are available. It is also comparable to or even better than the anomaly initialization methods. Better hindcasts of global mean surface air temperature anomaly are obtained due to the reduction of initial shock by the new initialization scheme.

  13. Lesion correlates of patholinguistic profiles in chronic aphasia: comparisons of syndrome-, modality- and symptom-level assessment.

    PubMed

    Henseler, Ilona; Regenbrecht, Frank; Obrig, Hellmuth

    2014-03-01

    One way to investigate the neuronal underpinnings of language competence is to correlate patholinguistic profiles of aphasic patients to corresponding lesion sites. Constituting the beginnings of aphasiology and neurolinguistics over a century ago, this approach has been revived and refined in the past decade by statistical approaches mapping continuous variables (providing metrics that are not simply categorical) on voxel-wise lesion information (voxel-based lesion-symptom mapping). Here we investigate whether and how voxel-based lesion-symptom mapping allows us to delineate specific lesion patterns for differentially fine-grained clinical classifications. The latter encompass 'classical' syndrome-based approaches (e.g. Broca's aphasia), more symptom-oriented descriptions (e.g. agrammatism) and further refinement to linguistic sub-functions (e.g. lexico-semantic deficits for inanimate versus animate items). From a large database of patients treated for aphasia of different aetiologies (n = 1167) a carefully selected group of 102 first ever ischaemic stroke patients with chronic aphasia (∅ 12 months) were included in a VLSM analysis. Specifically, we investigated how performance in the Aachen Aphasia Test-the standard clinical test battery for chronic aphasia in German-relates to distinct brain lesions. The Aachen Aphasia Test evaluates aphasia on different levels: a non-parametric discriminant procedure yields probabilities for the allocation to one of the four 'standard' syndromes (Broca, Wernicke, global and amnestic aphasia), whereas standardized subtests target linguistic modalities (e.g. repetition), or even more specific symptoms (e.g. phoneme repetition). Because some subtests of the Aachen Aphasia Test (e.g. for the linguistic level of lexico-semantics) rely on rather coarse and heterogeneous test items we complemented the analysis with a number of more detailed clinically used tests in selected mostly mildly affected subgroups of patients. Our results

  14. [RehaFuturReal®: Evaluation of Implementation in Organizational Structure and in Counseling Process - An Overview of Results].

    PubMed

    Arling, V; Knispel, J; Spijkers, W

    2016-08-01

    Due to prevailing future challenges in vocational rehabilitation, development process RehaFutur (BMAS) was initiated. In this context, recommendations were made to secure a future-oriented, innovative vocational rehabilitation in Germany. Deutsche Rentenversicherung (DRV) Westfalen transferred these recommendations into a new and applicable counseling concept RehaFutuReal(®). Rehabilitation managers (RM) are central protagonists in counseling process. Therefore, RehaFuturReal(®) focused on optimization of counseling performance. To achieve this aim, rehabilitation managers were taught to work with a case management (CM) based approach. RWTH Aachen supported RehaFuturReal(®) from an academic point of view and conducted a formative and summative evaluation. Primary aim of RWTH Aachen was to support DRV Westfalen during implementation of RehaFuturReal(®) into their organizational structure. Additionally, RWTH Aachen controlled whether transfer of RehaFutuReal(®) in counseling process was successful. From 04-01-13 until 12-31-14, RehaFuturReal(®) was tested by DRV Westfalen in the intervention district Dortmund with 10 RM. There were 3 selection criteria for the overall sample of N=320 insurants: participants were required to have an active employment status, suffered from integration issues and were in need of support to achieve vocational integration. Evaluation of RehaFuturReal(®) was realized summative (pre-post-comparison) and formative (process-orientated). Evaluative judgment regarding implementation in organizational structure and counseling process was performed by using three-stage-concept of Donabedian (quality of structure, process and results). Thereby, feedback of RM, insurants and employers was taken into account. Analysis of evaluation results revealed a positive overall impression. Implementation into organizational structure was successful on all 3 quality stages: concept of project and CM-training were an adequate basis and appropriately put

  15. Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease

    PubMed Central

    Appu, Abhilash P.; Moffett, John R.; Arun, Peethambaran; Moran, Sean; Nambiar, Vikram; Krishnan, Jishnu K. S.; Puthillathu, Narayanan; Namboodiri, Aryan M. A.

    2017-01-01

    Canavan disease is caused by mutations in the gene encoding aspartoacylase (ASPA), a deacetylase that catabolizes N-acetylaspartate (NAA). The precise involvement of elevated NAA in the pathogenesis of Canavan disease is an ongoing debate. In the present study, we tested the effects of elevated NAA in the brain during postnatal development. Mice were administered high doses of the hydrophobic methyl ester of NAA (M-NAA) twice daily starting on day 7 after birth. This treatment increased NAA levels in the brain to those observed in the brains of Nur7 mice, an established model of Canavan disease. We evaluated various serological parameters, oxidative stress, inflammatory and neurodegeneration markers and the results showed that there were no pathological alterations in any measure with increased brain NAA levels. We examined oxidative stress markers, malondialdehyde content (indicator of lipid peroxidation), expression of NADPH oxidase and nuclear translocation of the stress-responsive transcription factor nuclear factor (erythroid-derived 2)-like 2 (NRF-2) in brain. We also examined additional pathological markers by immunohistochemistry and the expression of activated caspase-3 and interleukin-6 by Western blot. None of the markers were increased in the brains of M-NAA treated mice, and no vacuoles were observed in any brain region. These results show that ASPA expression prevents the pathologies associated with excessive NAA concentrations in the brain during postnatal myelination. We hypothesize that the pathogenesis of Canavan disease involves not only disrupted NAA metabolism, but also excessive NAA related signaling processes in oligodendrocytes that have not been fully determined and we discuss some of the potential mechanisms. PMID:28626388

  16. Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma.

    PubMed

    Tsen, Andrew R; Long, Patrick M; Driscoll, Heather E; Davies, Matthew T; Teasdale, Benjamin A; Penar, Paul L; Pendlebury, William W; Spees, Jeffrey L; Lawler, Sean E; Viapiano, Mariano S; Jaworski, Diane M

    2014-03-15

    Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glioma; yet, few studies have investigated acetate as a potential therapeutic agent. This preclinical study sought to test the efficacy of the food additive Triacetin (glyceryl triacetate, GTA) as a novel therapy to increase acetate bioavailability in glioma cells. The growth-inhibitory effects of GTA, compared to the histone deacetylase inhibitor Vorinostat (SAHA), were assessed in established human glioma cell lines (HOG and Hs683 oligodendroglioma, U87 and U251 glioblastoma) and primary tumor-derived glioma stem-like cells (GSCs), relative to an oligodendrocyte progenitor line (Oli-Neu), normal astrocytes, and neural stem cells (NSCs) in vitro. GTA was also tested as a chemotherapeutic adjuvant with temozolomide (TMZ) in orthotopically grafted GSCs. GTA-induced cytostatic growth arrest in vitro comparable to Vorinostat, but, unlike Vorinostat, GTA did not alter astrocyte growth and promoted NSC expansion. GTA alone increased survival of mice engrafted with glioblastoma GSCs and potentiated TMZ to extend survival longer than TMZ alone. GTA was most effective on GSCs with a mesenchymal cell phenotype. Given that GTA has been chronically administered safely to infants with Canavan disease, a leukodystrophy due to ASPA mutation, GTA-mediated acetate supplementation may provide a novel, safe chemotherapeutic adjuvant to reduce the growth of glioma tumors, most notably the more rapidly proliferating, glycolytic and hypoacetylated mesenchymal glioma tumors. © 2013 UICC.

  17. A safety trial of high dose glyceryl triacetate for Canavan disease.

    PubMed

    Segel, Reeval; Anikster, Yair; Zevin, Shoshana; Steinberg, Avraham; Gahl, William A; Fisher, Drora; Staretz-Chacham, Orna; Zimran, Ari; Altarescu, Gheona

    2011-07-01

    Canavan disease (CD MIM#271900) is a rare autosomal recessive neurodegenerative disorder presenting in early infancy. The course of the disease is variable, but it is always fatal. CD is caused by mutations in the ASPA gene, which codes for the enzyme aspartoacylase (ASPA), which breaks down N-acetylaspartate (NAA) to acetate and aspartic acid. The lack of NAA-degrading enzyme activity leads to excess accumulation of NAA in the brain and deficiency of acetate, which is necessary for myelin lipid synthesis. Glyceryltriacetate (GTA) is a short-chain triglyceride with three acetate moieties on a glycerol backbone and has proven an effective acetate precursor. Intragastric administration of GTA to tremor mice results in greatly increased brain acetate levels, and improved motor functions. GTA given to infants with CD at a low dose (up to 0.25 g/kg/d) resulted in no improvement in their clinical status, but also no detectable toxicity. We present for the first time the safety profile of high dose GTA (4.5 g/kg/d) in 2 patients with CD. We treated 2 infants with CD at ages 8 months and 1 year with high dose GTA, for 4.5 and 6 months respectively. No significant side effects and no toxicity were observed. Although the treatment resulted in no motor improvement, it was well tolerated. The lack of clinical improvement might be explained mainly by the late onset of treatment, when significant brain damage was already present. Further larger studies of CD patients below age 3 months are required in order to test the long-term efficacy of this drug. Copyright © 2011 Elsevier Inc. All rights reserved.

  18. Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma

    PubMed Central

    Tsen, Andrew R.; Long, Patrick M.; Driscoll, Heather E.; Davies, Matthew T.; Teasdale, Benjamin A.; Penar, Paul L.; Pendlebury, William W.; Spees, Jeffrey L.; Lawler, Sean E.; Viapiano, Mariano S.; Jaworski, Diane M.

    2013-01-01

    Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glioma; yet, few studies have investigated acetate as a potential therapeutic agent. This preclinical study sought to test the efficacy of the food additive Triacetin (glyceryl triacetate, GTA) as a novel therapy to increase acetate bioavailability in glioma cells. The growth-inhibitory effects of GTA, compared to the histone deacetylase inhibitor Vorinostat (SAHA), were assessed in established human glioma cell lines (HOG and Hs683 oligodendroglioma, U87 and U251 glioblastoma) and primary tumor-derived glioma stem-like cells (GSCs), relative to an oligodendrocyte progenitor line (Oli-Neu), normal astrocytes, and neural stem cells (NSCs) in vitro. GTA was also tested as a chemotherapeutic adjuvant with temozolomide (TMZ) in orthotopically grafted GSCs. GTA induced cytostatic growth arrest in vitro comparable to Vorinostat, but, unlike Vorinostat, GTA did not alter astrocyte growth and promoted NSC expansion. GTA alone increased survival of mice engrafted with glioblastoma GSCs and potentiated TMZ to extend survival longer than TMZ alone. GTA was most effective on GSCs with a mesenchymal cell phenotype. Given that GTA has been chronically administered safely to infants with Canavan disease, a leukodystrophy due to ASPA mutation, GTA-mediated acetate supplementation may provide a novel, safe chemotherapeutic adjuvant to reduce the growth of glioma tumors, most notably the more rapidly proliferating, glycolytic, and hypoacetylated mesenchymal glioma tumors. PMID:23996800

  19. A Martingale Characterization of Mixed Poisson Processes.

    DTIC Science & Technology

    1985-10-01

    03LA A 11. TITLE (Inciuae Security Clanafication, ",A martingale characterization of mixed Poisson processes " ________________ 12. PERSONAL AUTHOR... POISSON PROCESSES Jostification .......... . ... . . Di.;t ib,,jtion by Availability Codes Dietmar Pfeifer* Technical University Aachen Dist Special and...Mixed Poisson processes play an important role in many branches of applied probability, for instance in insurance mathematics and physics (see Albrecht

  20. Reduction of initial shock in decadal predictions using a new initialization strategy

    NASA Astrophysics Data System (ADS)

    He, Yujun; Wang, Bin; Liu, Mimi; Liu, Li; Yu, Yongqiang; Liu, Juanjuan; Li, Ruizhe; Zhang, Cheng; Xu, Shiming; Huang, Wenyu; Liu, Qun; Wang, Yong; Li, Feifei

    2017-08-01

    A novel full-field initialization strategy based on the dimension-reduced projection four-dimensional variational data assimilation (DRP-4DVar) is proposed to alleviate the well-known initial shock occurring in the early years of decadal predictions. It generates consistent initial conditions, which best fit the monthly mean oceanic analysis data along the coupled model trajectory in 1 month windows. Three indices to measure the initial shock intensity are also proposed. Results indicate that this method does reduce the initial shock in decadal predictions by Flexible Global Ocean-Atmosphere-Land System model, Grid-point version 2 (FGOALS-g2) compared with the three-dimensional variational data assimilation-based nudging full-field initialization for the same model and is comparable to or even better than the different initialization strategies for other fifth phase of the Coupled Model Intercomparison Project (CMIP5) models. Better hindcasts of global mean surface air temperature anomalies can be obtained than in other FGOALS-g2 experiments. Due to the good model response to external forcing and the reduction of initial shock, higher decadal prediction skill is achieved than in other CMIP5 models.

  1. Exposure of healthy subjects with emissions from a gas metal arc welding process: part 1--exposure technique and external exposure.

    PubMed

    Brand, P; Havlicek, P; Steiners, M; Holzinger, K; Reisgen, U; Kraus, T; Gube, M

    2013-01-01

    Studies concerning welding fume-related adverse health effects in welders are hampered by the heterogeneity of workplace situations, resulting in complex and non-standardized exposure conditions. In order to carry out welding fume exposure studies under controlled and standardized conditions, the Aachen Workplace Simulation Laboratory was developed. This laboratory consists of an emission room, in which welding fume is produced, and an exposure room in which human subjects are exposed to these fumes. Both rooms are connected by a ventilation system which allows the welding fume concentration to be regulated. Particle mass concentration was measured with a TEOM microbalance and the particle number-size distribution using a Grimm SMPS device. In a study, which is the subject of this paper, it has been shown that welding fume concentration can easily be regulated between 1 and about 3 mg m(-3). The chosen concentration can be kept constant for more than 8 h. However, transport of the particles from the emission room into the exposure room leads to a change in particle size distribution, which is probably due to coagulation of the fraction of smallest particles. The Aachen Workplace Simulation Laboratory is suitable for controlled exposure studies with human subjects.

  2. On Education and Initiation

    ERIC Educational Resources Information Center

    Luntley, Michael

    2009-01-01

    In this paper I take up Peters' invitation to think of education in terms of initiation. I argue that the concept of initiation demands much closer scrutiny and analysis in order to provide a substantive thesis about education. A key challenge concerns how we conceive of the initiate. The very idea of initiation suggests that, in some interesting…

  3. Hypothermic oxygenated machine perfusion (HOPE) for orthotopic liver transplantation of human liver allografts from extended criteria donors (ECD) in donation after brain death (DBD): a prospective multicentre randomised controlled trial (HOPE ECD-DBD).

    PubMed

    Czigany, Zoltan; Schöning, Wenzel; Ulmer, Tom Florian; Bednarsch, Jan; Amygdalos, Iakovos; Cramer, Thorsten; Rogiers, Xavier; Popescu, Irinel; Botea, Florin; Froněk, Jiří; Kroy, Daniela; Koch, Alexander; Tacke, Frank; Trautwein, Christian; Tolba, Rene H; Hein, Marc; Koek, Ger H; Dejong, Cornelis H C; Neumann, Ulf Peter; Lurje, Georg

    2017-10-10

    Orthotopic liver transplantation (OLT) has emerged as the mainstay of treatment for end-stage liver disease. In an attempt to improve the availability of donor allografts and reduce waiting list mortality, graft acceptance criteria were extended increasingly over the decades. The use of extended criteria donor (ECD) allografts is associated with a higher incidence of primary graft non-function and/or delayed graft function. As such, several strategies have been developed aiming at reconditioning poor quality ECD liver allografts. Hypothermic oxygenated machine perfusion (HOPE) has been successfully tested in preclinical experiments and in few clinical series of donation after cardiac death OLT. HOPE ECD-DBD is an investigator-initiated, open-label, phase-II, prospective multicentre randomised controlled trial on the effects of HOPE on ECD allografts in donation after brain death (DBD) OLT. Human whole organ liver grafts will be submitted to 1-2 hours of HOPE (n=23) via the portal vein before implantation and are going to be compared with a control group (n=23) of patients transplanted after conventional cold storage. Primary (peak and Δ peak alanine aminotransferase within 7 days) and secondary (aspartate aminotransferase, bilirubin and international normalised ratio, postoperative complications, early allograft dysfunction, duration of hospital and intensive care unit stay, 1-year patient and graft survival) endpoints will be analysed within a 12-month follow-up. Extent of ischaemia-reperfusion (I/R) injury will be assessed using liver tissue, perfusate, bile and serum samples taken during the perioperative phase of OLT. The study was approved by the institutional review board of the RWTH Aachen University, Aachen, Germany (EK 049/17). The current paper represent the pre-results phase. First results are expected in 2018. NCT03124641. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No

  4. Nonlinear Hyperbolic Equations - Theory, Computation Methods, and Applications. Volume 24. Note on Numerical Fluid Mechanics

    DTIC Science & Technology

    1989-01-01

    Calculations and Experiments (B.van den Berg/ D.A. Humphreysl E. Krause /J.P. F. Lindhout) Volume 20 Proceedings of the Seventh GAMM-Conference on...GRID METHODS FOR HYPERBOLIC PROBLEMS Wolfgang Hackbusch Sigrid Hagemann Institut fUr Informatik und Praktische Mathematik Christian-Albrechts...Euler Equations. Proceedings of the 8th Inter- national Conference on Numerical Methods in Fluid Dynamics (E. Krause , ed.), Aachen, 1988. Springer

  5. Selections From Kung-Jen JIH-PAO (Source Span: 9 May-30 June 1961) Number 7 -Communist China.

    DTIC Science & Technology

    1961-08-17

    sulphate Ammonium hydrogen carbonate Sodium borate Titaniüm-iron powder Sodium fluoride Silicon dioxide Barium chloride beryllium carbonate ...Vinzenstrasse, 22a :■ P. 0. Box 3521 Aachen, Germany Washington 7> B.C. , Institute de Sociologie Solvay Rue du Chatelain, k9 Brussels, Belgium State... Sodium nitrite Specifications Pure n industrial Boric Acid " A^ua ammonia " Magnesium sulphate Industrial Manganese tedroxide Pure

  6. Western Mountain Initiative

    Science.gov Websites

    Home About WMI People Publications News Media Research Links Western Mountain Initiative The Western Mountain Initiative is a team of USGS, US Forest Service, and university scientists working to

  7. Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families

    NASA Technical Reports Server (NTRS)

    Kyrpides, N. C.; Woese, C. R.

    1998-01-01

    As the amount of available sequence data increases, it becomes apparent that our understanding of translation initiation is far from comprehensive and that prior conclusions concerning the origin of the process are wrong. Contrary to earlier conclusions, key elements of translation initiation originated at the Universal Ancestor stage, for homologous counterparts exist in all three primary taxa. Herein, we explore the evolutionary relationships among the components of bacterial initiation factor 2 (IF-2) and eukaryotic IF-2 (eIF-2)/eIF-2B, i.e., the initiation factors involved in introducing the initiator tRNA into the translation mechanism and performing the first step in the peptide chain elongation cycle. All Archaea appear to posses a fully functional eIF-2 molecule, but they lack the associated GTP recycling function, eIF-2B (a five-subunit molecule). Yet, the Archaea do posses members of the gene family defined by the (related) eIF-2B subunits alpha, beta, and delta, although these are not specifically related to any of the three eukaryotic subunits. Additional members of this family also occur in some (but by no means all) Bacteria and even in some eukaryotes. The functional significance of the other members of this family is unclear and requires experimental resolution. Similarly, the occurrence of bacterial IF-2-like molecules in all Archaea and in some eukaryotes further complicates the picture of translation initiation. Overall, these data lend further support to the suggestion that the rudiments of translation initiation were present at the Universal Ancestor stage.

  8. Dioxin Exposure Initiative

    EPA Pesticide Factsheets

    The Dioxin Exposure Initiative (DEI) is no longer active. This page contains a summary of the dioxin exposure initiative with illustrations, contact and background information.Originally supported by scientist Matthew Lorber, who retired in Mar 2017.

  9. Prioritizing Scientific Initiatives.

    ERIC Educational Resources Information Center

    Bahcall, John N.

    1991-01-01

    Discussed is the way in which a limited number of astronomy research initiatives were chosen and prioritized based on a consensus of members from the Astronomy and Astrophysics Survey Committee. A list of recommended equipment initiatives and estimated costs is provided. (KR)

  10. Community Rates of Breastfeeding Initiation.

    PubMed

    Grubesic, Tony H; Durbin, Kelly M

    2016-11-01

    Breastfeeding initiation rates vary considerably across racial and ethnic groups, maternal age, and education level, yet there are limited data concerning the influence of geography on community rates of breastfeeding initiation. This study aimed to describe how community rates of breastfeeding initiation vary in geographic space, highlighting "hot spots" and "cool spots" of initiation and exploring the potential connections between race, socioeconomic status, and urbanization levels on these patterns. Birth certificate data from the Kentucky Department of Health for 2004-2010 were combined with county-level geographic base files, Census 2010 demographic and socioeconomic data, and Rural-Urban Continuum Codes to conduct a spatial statistical analysis of community rates of breastfeeding initiation. Between 2004 and 2010, the average rate of breastfeeding initiation for Kentucky increased from 43.84% to 49.22%. Simultaneously, the number of counties identified as breastfeeding initiation hot spots also increased, displaying a systematic geographic pattern in doing so. Cool spots of breastfeeding initiation persisted in rural, Appalachian Kentucky. Spatial regression results suggested that unemployment, income, race, education, location, and the availability of International Board Certified Lactation Consultants are connected to breastfeeding initiation. Not only do spatial analytics facilitate the identification of breastfeeding initiation hot spots and cool spots, but they can be used to better understand the landscape of breastfeeding initiation and help target breastfeeding education and/or support efforts.

  11. Piezoelectrically Initiated Pyrotechnic Igniter

    NASA Technical Reports Server (NTRS)

    Quince, Asia; Dutton, Maureen; Hicks, Robert; Burnham, Karen

    2013-01-01

    This innovation consists of a pyrotechnic initiator and piezoelectric initiation system. The device will be capable of being initiated mechanically; resisting initiation by EMF, RF, and EMI (electromagnetic field, radio frequency, and electromagnetic interference, respectively); and initiating in water environments and space environments. Current devices of this nature are initiated by the mechanical action of a firing pin against a primer. Primers historically are prone to failure. These failures are commonly known as misfires or hang-fires. In many cases, the primer shows the dent where the firing pin struck the primer, but the primer failed to fire. In devices such as "T" handles, which are commonly used to initiate the blowout of canopies, loss of function of the device may result in loss of crew. In devices such as flares or smoke generators, failure can result in failure to spot a downed pilot. The piezoelectrically initiated ignition system consists of a pyrotechnic device that plugs into a mechanical system (activator), which on activation, generates a high-voltage spark. The activator, when released, will strike a stack of electrically linked piezo crystals, generating a high-voltage, low-amperage current that is then conducted to the pyro-initiator. Within the initiator, an electrode releases a spark that passes through a pyrotechnic first-fire mixture, causing it to combust. The combustion of the first-fire initiates a primary pyrotechnic or explosive powder. If used in a "T" handle, the primary would ramp the speed of burn up to the speed of sound, generating a shock wave that would cause a high explosive to go "high order." In a flare or smoke generator, the secondary would produce the heat necessary to ignite the pyrotechnic mixture. The piezo activator subsystem is redundant in that a second stack of crystals would be struck at the same time with the same activation force, doubling the probability of a first strike spark generation. If the first

  12. Operational Initiative Review Report of The Small Business Development Center Initiative.

    ERIC Educational Resources Information Center

    Orr-Carpenter, Deborah

    This document discusses the Small Business Development Center initiative which addresses the needs of California businesses to grow through the delivery of one-on-one counseling, seminars, workshops, conferences, and other technical activities. The community colleges host 21 full centers. Some of the major objectives of the initiative are the…

  13. Low-melting elemental metal or fusible alloy encapsulated polymerization initiator for delayed initiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hermes, Robert E.

    2017-08-15

    An encapsulated composition for polymerization includes an initiator composition for initiating a polymerization reaction, and a capsule prepared from an elemental metal or fusible alloy having a melting temperature from about 20.degree. C. to about 200.degree. C. A fluid for polymerization includes the encapsulated composition and a monomer. When the capsule melts or breaks open, the initiator is released.

  14. AC Initiation System.

    DTIC Science & Technology

    An ac initiation system is described which uses three ac transmission signals interlocked for safety by frequency, phase, and power discrimination...The ac initiation system is pre-armed by the application of two ac signals have the proper phases, and activates a load when an ac power signal of the proper frequency and power level is applied. (Author)

  15. Autonomous aircraft initiative study

    NASA Technical Reports Server (NTRS)

    Hewett, Marle D.

    1991-01-01

    The results of a consulting effort to aid NASA Ames-Dryden in defining a new initiative in aircraft automation are described. The initiative described is a multi-year, multi-center technology development and flight demonstration program. The initiative features the further development of technologies in aircraft automation already being pursued at multiple NASA centers and Department of Defense (DoD) research and Development (R and D) facilities. The proposed initiative involves the development of technologies in intelligent systems, guidance, control, software development, airborne computing, navigation, communications, sensors, unmanned vehicles, and air traffic control. It involves the integration and implementation of these technologies to the extent necessary to conduct selected and incremental flight demonstrations.

  16. [Rehabilitation prognosis of aphasias of various etiologies with reference to clinical, neurolinguistic and computerized tomography findings].

    PubMed

    Mezger, G; Busch, G

    1988-05-01

    To obtain further insights into the rehabilitation outlook in different baseline conditions, a comparison was made of data and treatment outcomes in 92 patients having aphasias of different etiology and disease duration. Rating as "improved" was contingent on significant changes in at least 2 subtests of the AAT (Aachener Aphasietest), which is a fairly stringent requirement. This criterion was met by some 35% of the patients overall, independent of their age; the percentage increased to 45% in case of treatment onset during the first year, while in later onset, significant improvement was achieved in 15% only. Aphasic syndromes secondary to hemorrhage, trauma, tumors, or infections, usually are less severe than the predominant classical syndromes, i.e. Global, Broca and Wernicke aphasia, caused by ischemic stroke. CT lesion size did not yield any definite information. Minor improvements below the required significance levels, and, above all, gains in communication performance, i.e. further consolidation, could be achieved by appropriate management even after the crucial initial year, which, however, does not imply any fundamental changes in the rehabilitation prognosis as such.

  17. DNA replication initiator Cdc6 also regulates ribosomal DNA transcription initiation.

    PubMed

    Huang, Shijiao; Xu, Xiaowei; Wang, Guopeng; Lu, Guoliang; Xie, Wenbing; Tao, Wei; Zhang, Hongyin; Jiang, Qing; Zhang, Chuanmao

    2016-04-01

    RNA-polymerase-I-dependent ribosomal DNA (rDNA) transcription is fundamental to rRNA processing, ribosome assembly and protein synthesis. However, how this process is initiated during the cell cycle is not fully understood. By performing a proteomic analysis of transcription factors that bind RNA polymerase I during rDNA transcription initiation, we identified that the DNA replication initiator Cdc6 interacts with RNA polymerase I and its co-factors, and promotes rDNA transcription in G1 phase in an ATPase-activity-dependent manner. We further showed that Cdc6 is targeted to the nucleolus during late mitosis and G1 phase in a manner that is dependent on B23 (also known as nucleophosmin, NPM1), and preferentially binds to the rDNA promoter through its ATP-binding domain. Overexpression of Cdc6 increases rDNA transcription, whereas knockdown of Cdc6 results in a decreased association of both RNA polymerase I and the RNA polymerase I transcription factor RRN3 with rDNA, and a reduction of rDNA transcription. Furthermore, depletion of Cdc6 impairs the interaction between RRN3 and RNA polymerase I. Taken together, our data demonstrate that Cdc6 also serves as a regulator of rDNA transcription initiation, and indicate a mechanism by which initiation of rDNA transcription and DNA replication can be coordinated in cells. © 2016. Published by The Company of Biologists Ltd.

  18. Transcription initiation from the dihydrofolate reductase promoter is positioned by HIP1 binding at the initiation site.

    PubMed

    Means, A L; Farnham, P J

    1990-02-01

    We have identified a sequence element that specifies the position of transcription initiation for the dihydrofolate reductase gene. Unlike the functionally analogous TATA box that directs RNA polymerase II to initiate transcription 30 nucleotides downstream, the positioning element of the dihydrofolate reductase promoter is located directly at the site of transcription initiation. By using DNase I footprint analysis, we have shown that a protein binds to this initiator element. Transcription initiated at the dihydrofolate reductase initiator element when 28 nucleotides were inserted between it and all other upstream sequences, or when it was placed on either side of the DNA helix, suggesting that there is no strict spatial requirement between the initiator and an upstream element. Although neither a single Sp1-binding site nor a single initiator element was sufficient for transcriptional activity, the combination of one Sp1-binding site and the dihydrofolate reductase initiator element cloned into a plasmid vector resulted in transcription starting at the initiator element. We have also shown that the simian virus 40 late major initiation site has striking sequence homology to the dihydrofolate reductase initiation site and that the same, or a similar, protein binds to both sites. Examination of the sequences at other RNA polymerase II initiation sites suggests that we have identified an element that is important in the transcription of other housekeeping genes. We have thus named the protein that binds to the initiator element HIP1 (Housekeeping Initiator Protein 1).

  19. Diffusion controlled initial recombination

    NASA Astrophysics Data System (ADS)

    Christen, T.; Büttiker, M.

    1998-08-01

    This work addresses nucleation rates in systems with strong initial recombination. Initial (or ``geminate'') recombination is a process where a dissociated structure (anion, vortex, kink, etc.) recombines with its twin brother (cation, antivortex, antikink) generated in the same nucleation event. Initial recombination is important if there is an asymptotically vanishing interaction force instead of a generic saddle-type activation barrier. At low temperatures, initial recombination strongly dominates homogeneous recombination. In a first part, we discuss the effect in one-, two-, and three-dimensional diffusion controlled systems with spherical symmetry. Since there is no well-defined saddle, we introduce a threshold which is to some extent arbitrary but which is restricted by physically reasonable conditions. We show that the dependence of the nucleation rate on the specific choice of this threshold is strongest for one-dimensional systems and decreases in higher dimensions. We also discuss the influence of a weak driving force, and show that the transport current is directly determined by the imbalance of the activation rate in the direction of the field and the rate against this direction. In a second part, we apply the results to the overdamped sine-Gordon system at equilibrium. It turns out that diffusive initial recombination is the essential mechanism which governs the equilibrium kink nucleation rate. We emphasize analogies between the single particle problem with initial recombination and the multidimensional kink-antikink nucleation problem.

  20. Space Exploration Initiative: Chronology

    NASA Technical Reports Server (NTRS)

    McCurdy, Howard E.

    1992-01-01

    This chronology gives an overview of the human space exploration initiative from 1956 through 1989. Details are given for the political milestones of the initiative, including information on presidential mandates and NASA Administrator appointments.

  1. National Take-Back Initiative

    MedlinePlus

    ... Disposal Information Drug and Chemical Information E-commerce Initiatives Federal Agencies & Related Links Federal Register Notices National ... Disposal Information Drug and Chemical Information E-commerce Initiatives Federal Agencies & Related Links Federal Register Notices National ...

  2. Personality Traits and Training Initiation Process: Intention, Planning, and Action Initiation

    PubMed Central

    Laguna, Mariola; Purc, Ewelina

    2016-01-01

    The article aims at investigating the role of personality traits in relation to training initiation. Training initiation is conceptualized as a goal realization process, and explained using goal theories. There are three stages of the process analyzed: intention to undertake training, plan formulation, and actual training undertaking. Two studies tested the relationships between five personality traits, defined according to the five factor model, and the stages of the goal realization process. In Study 1, which explains training intention and training plans’ formulation, 155 employees participated. In Study 2, which was time-lagged with two measurement points, and which explains intention, plans, and training actions undertaken, the data from 176 employees was collected at 3 month intervals. The results of these studies show that personality traits, mainly openness to experience, predict the training initiation process to some degree: intention, plans, and actual action initiation. The findings allow us to provide recommendations for practitioners responsible for human resource development. The assessment of openness to experience in employees helps predict their motivation to participate in training activities. To increase training motivation it is vital to strengthen intentions to undertake training, and to encourage training action planning. PMID:27909414

  3. Personality Traits and Training Initiation Process: Intention, Planning, and Action Initiation.

    PubMed

    Laguna, Mariola; Purc, Ewelina

    2016-01-01

    The article aims at investigating the role of personality traits in relation to training initiation. Training initiation is conceptualized as a goal realization process, and explained using goal theories. There are three stages of the process analyzed: intention to undertake training, plan formulation, and actual training undertaking. Two studies tested the relationships between five personality traits, defined according to the five factor model, and the stages of the goal realization process. In Study 1, which explains training intention and training plans' formulation, 155 employees participated. In Study 2, which was time-lagged with two measurement points, and which explains intention, plans, and training actions undertaken, the data from 176 employees was collected at 3 month intervals. The results of these studies show that personality traits, mainly openness to experience, predict the training initiation process to some degree: intention, plans, and actual action initiation. The findings allow us to provide recommendations for practitioners responsible for human resource development. The assessment of openness to experience in employees helps predict their motivation to participate in training activities. To increase training motivation it is vital to strengthen intentions to undertake training, and to encourage training action planning.

  4. Initiation disruptor systems and methods of initiation disruption

    DOEpatents

    Baum, Dennis W

    2014-09-23

    A system that may be used as an initiation disruption system (IDS) according to one embodiment includes an explosive charge; a plurality of particles in a layer at least partially surrounding the explosive charge; and a fire suppressant adjacent the plurality of particles. A method for disabling an object according to one embodiment includes placing the system as recited above near an object; and causing the explosive charge to initiate, thereby applying mechanical loading to the object such that the object becomes disabled. Additional systems and methods are also presented. A device according to another embodiment includes a plurality of particles bound by a binder thereby defining a sidewall having an interior for receiving an explosive; and a fire suppressant adjacent the plurality of particles and binder. Additional systems and methods are also presented.

  5. Capacity Initiatives, Volume 2

    DOT National Transportation Integrated Search

    1992-07-01

    This is the second in a series of pamphlets detailing capacity initiatives that : offer solutions for improving the Nation's aviation system capacity. Based on : the application and refinement of new systems and procedures, these initiatives : promis...

  6. Non-canonical transcription initiation: the expanding universe of transcription initiating substrates.

    PubMed

    Barvík, Ivan; Rejman, Dominik; Panova, Natalya; Šanderová, Hana; Krásný, Libor

    2017-03-01

    RNA polymerase (RNAP) is the central enzyme of transcription of the genetic information from DNA into RNA. RNAP recognizes four main substrates: ATP, CTP, GTP and UTP. Experimental evidence from the past several years suggests that, besides these four NTPs, other molecules can be used to initiate transcription: (i) ribooligonucleotides (nanoRNAs) and (ii) coenzymes such as NAD+, NADH, dephospho-CoA and FAD. The presence of these molecules at the 5΄ ends of RNAs affects the properties of the RNA. Here, we discuss the expanding portfolio of molecules that can initiate transcription, their mechanism of incorporation, effects on RNA and cellular processes, and we present an outlook toward other possible initiation substrates. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  7. Direct medical costs and medication compliance among fibromyalgia patients: duloxetine initiators vs. pregabalin initiators.

    PubMed

    Sun, Peter; Peng, Xiaomei; Sun, Steve; Novick, Diego; Faries, Douglas E; Andrews, Jeffrey S; Wohlreich, Madelaine M; Wu, Andrew

    2014-01-01

    To assess and compare direct medical costs and medication compliance between patients with fibromyalgia who initiated duloxetine and patients with fibromyalgia who initiated pregabalin in 2008. A retrospective cohort study design was used based on a large US national commercial claims database (2006 to 2009). Patients with fibromyalgia aged 18 to 64 who initiated duloxetine or pregabalin in 2008 and who had continuous health insurance 1 year preceding and 1 year following the initiation were selected into duloxetine cohort or pregabalin cohort based on their initiated agent. Medication compliance was measured by total supply days, medication possession ratio (MPR), and proportion of patients with MPR ≥ 0.8. Direct medical costs were measured by annual costs per patient and compared between the cohorts in the year following the initiation. Propensity score stratification and bootstrapping methods were used to adjust for distribution bias, as well as cross-cohort differences in demographic, clinical and economic characteristics, and medication history prior to the initiation. Both the duloxetine (n = 3,033) and pregabalin (n = 4,838) cohorts had a mean initiation age around 49 years, 89% were women. During the postindex year, compared to the pregabalin cohort, the duloxetine cohort had higher totally annual supply days (273.5 vs. 176.6, P < 0.05), higher MPR (0.7 vs. 0.5, P < 0.05), and more patients with MPR ≥ 0.8 (45.1% vs. 29.4%, P < 0.05). Further, relative to pregabalin cohort, duloxetine cohort had lower inpatient costs ($2,994.9 vs. $4,949.6, P < 0.05), lower outpatient costs ($8,259.6 vs. $10,312.2, P < 0.05), similar medication costs ($5,214.6 vs. $5,290.8, P > 0.05), and lower total medical costs ($16,469.1 vs. $20,552.6, P < 0.05) in the postinitiation year. In a real-world setting, patients with fibromyalgia who initiated duloxetine in 2008 had better medication compliance and consumed less inpatient, outpatient, and total

  8. Statistical distribution of time to crack initiation and initial crack size using service data

    NASA Technical Reports Server (NTRS)

    Heller, R. A.; Yang, J. N.

    1977-01-01

    Crack growth inspection data gathered during the service life of the C-130 Hercules airplane were used in conjunction with a crack propagation rule to estimate the distribution of crack initiation times and of initial crack sizes. A Bayesian statistical approach was used to calculate the fraction of undetected initiation times as a function of the inspection time and the reliability of the inspection procedure used.

  9. The Fostering Hope Initiative

    ERIC Educational Resources Information Center

    Rider, Steven; Winters, Katie; Dean, Joyce; Seymour, Jim

    2014-01-01

    The Fostering Hope Initiative is a neighborhood-based Collective Impact initiative that promotes optimum child and youth development by supporting vulnerable families, encouraging connections between neighbors, strengthening systems to ensure collective impact, and advocating for family-friendly public policy. This article describes the…

  10. Gaseous detonation initiation via wave implosion

    NASA Astrophysics Data System (ADS)

    Jackson, Scott Irving

    Efficient detonation initiation is a topic of intense interest to designers of pulse detonation engines. This experimental work is the first to detonate propane-air mixtures with an imploding detonation wave and to detonate a gas mixture with a non-reflected, imploding shock. In order to do this, a unique device has been developed that is capable of generating an imploding toroidal detonation wave inside of a tube from a single ignition point without any obstruction to the tube flow path. As part of this study, an initiator that creates a large-aspect-ratio planar detonation wave in gas-phase explosive from a single ignition point has also been developed. The effectiveness of our initiation devices has been evaluated. The minimum energy required by the imploding shock for initiation was determined to scale linearly with the induction zone length, indicating the presence of a planar initiation mode. The imploding toroidal detonation initiator was found to be more effective at detonation initiation than the imploding shock initiator, using a comparable energy input to that of current initiator tubes.

  11. Characteristics code for shock initiation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Partom, Y.

    1986-10-01

    We developed SHIN, a characteristics code for shock initiation studies. We describe in detail the equations of state, reaction model, rate equations, and numerical difference equations that SHIN incorporates. SHIN uses the previously developed surface burning reaction model which better represents the shock initiation process in TATB, than do bulk reaction models. A large number of computed simulations prove the code is a reliable and efficient tool for shock initiation studies. A parametric study shows the effect on build-up and run distance to detonation of (1) type of boundary condtion, (2) burning velocity curve, (3) shock duration, (4) rise timemore » in ramp loading, (5) initial density (or porosity) of the explosive, (6) initial temperature, and (7) grain size. 29 refs., 65 figs.« less

  12. Ports Initiative

    EPA Pesticide Factsheets

    EPA's Ports Initiative works in collaboration with the port industry, communities, and government to improve environmental performance and increase economic prosperity. This effort helps people near ports breath cleaner air and live better lives.

  13. Thin-film optical initiator

    DOEpatents

    Erickson, Kenneth L.

    2001-01-01

    A thin-film optical initiator having an inert, transparent substrate, a reactive thin film, which can be either an explosive or a pyrotechnic, and a reflective thin film. The resultant thin-film optical initiator system also comprises a fiber-optic cable connected to a low-energy laser source, an output charge, and an initiator housing. The reactive thin film, which may contain very thin embedded layers or be a co-deposit of a light-absorbing material such as carbon, absorbs the incident laser light, is volumetrically heated, and explodes against the output charge, imparting about 5 to 20 times more energy than in the incident laser pulse.

  14. 76 FR 25328 - New Mexico Green Initiatives, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-04

    ... Mexico Green Initiatives, LLC's application for market-based rate authority, with an accompanying rate... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-3431-000] New Mexico Green Initiatives, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for...

  15. Initiation Capacity of a Specially Shaped Booster Pellet and Numerical Simulation of Its Initiation Process

    NASA Astrophysics Data System (ADS)

    Hu, Li-Shuang; Hu, Shuang-Qi; Cao, Xiong; Zhang, Jian-Ren

    2014-01-01

    The insensitive main charge explosive is creating new requirements for the booster pellet of detonation trains. The traditional cylindrical booster pellet has insufficient energy output to reliably initiate the insensitive main charge explosive. In this research, a concave spherical booster pellet was designed. The initiation capacity of the concave spherical booster pellet was studied using varied composition and axial steel dent methods. The initiation process of the concave spherical booster pellet was also simulated by ANSYS/LS-DYNA. The results showed that using a concave spherical booster allows a 42% reduction in the amount of explosive needed to match the initiation capacity of a conventional cylindrical booster of the same dimensions. With the other parameters kept constant, the initiation capacity of the concave spherical booster pellet increases with decreased cone angle and concave radius. The numerical simulation results are in good agreement with the experimental data.

  16. Creation and Initial Validation of the International Dysphagia Diet Standardisation Initiative Functional Diet Scale

    PubMed Central

    Steele, Catriona M.; Namasivayam-MacDonald, Ashwini M.; Guida, Brittany T.; Cichero, Julie A.; Duivestein, Janice; MRSc; Hanson, Ben; Lam, Peter; Riquelme, Luis F.

    2018-01-01

    Objective To assess consensual validity, interrater reliability, and criterion validity of the International Dysphagia Diet Standardisation Initiative Functional Diet Scale, a new functional outcome scale intended to capture the severity of oropharyngeal dysphagia, as represented by the degree of diet texture restriction recommended for the patient. Design Participants assigned International Dysphagia Diet Standardisation Initiative Functional Diet Scale scores to 16 clinical cases. Consensual validity was measured against reference scores determined by an author reference panel. Interrater reliability was measured overall and across quartile subsets of the dataset. Criterion validity was evaluated versus Functional Oral Intake Scale (FOIS) scores assigned by survey respondents to the same case scenarios. Feedback was requested regarding ease and likelihood of use. Setting Web-based survey. Participants Respondents (NZ170) from 29 countries. Interventions Not applicable. Main Outcome Measures Consensual validity (percent agreement and Kendall t), criterion validity (Spearman rank correlation), and interrater reliability (Kendall concordance and intraclass coefficients). Results The International Dysphagia Diet Standardisation Initiative Functional Diet Scale showed strong consensual validity, criterion validity, and interrater reliability. Scenarios involving liquid-only diets, transition from nonoral feeding, or trial diet advances in therapy showed the poorest consensus, indicating a need for clear instructions on how to score these situations. The International Dysphagia Diet Standardisation Initiative Functional Diet Scale showed greater sensitivity than the FOIS to specific changes in diet. Most (>70%) respondents indicated enthusiasm for implementing the International Dysphagia Diet Standardisation Initiative Functional Diet Scale. Conclusions This initial validation study suggests that the International Dysphagia Diet Standardisation Initiative Functional

  17. Creation and Initial Validation of the International Dysphagia Diet Standardisation Initiative Functional Diet Scale.

    PubMed

    Steele, Catriona M; Namasivayam-MacDonald, Ashwini M; Guida, Brittany T; Cichero, Julie A; Duivestein, Janice; Hanson, Ben; Lam, Peter; Riquelme, Luis F

    2018-05-01

    To assess consensual validity, interrater reliability, and criterion validity of the International Dysphagia Diet Standardisation Initiative Functional Diet Scale, a new functional outcome scale intended to capture the severity of oropharyngeal dysphagia, as represented by the degree of diet texture restriction recommended for the patient. Participants assigned International Dysphagia Diet Standardisation Initiative Functional Diet Scale scores to 16 clinical cases. Consensual validity was measured against reference scores determined by an author reference panel. Interrater reliability was measured overall and across quartile subsets of the dataset. Criterion validity was evaluated versus Functional Oral Intake Scale (FOIS) scores assigned by survey respondents to the same case scenarios. Feedback was requested regarding ease and likelihood of use. Web-based survey. Respondents (N=170) from 29 countries. Not applicable. Consensual validity (percent agreement and Kendall τ), criterion validity (Spearman rank correlation), and interrater reliability (Kendall concordance and intraclass coefficients). The International Dysphagia Diet Standardisation Initiative Functional Diet Scale showed strong consensual validity, criterion validity, and interrater reliability. Scenarios involving liquid-only diets, transition from nonoral feeding, or trial diet advances in therapy showed the poorest consensus, indicating a need for clear instructions on how to score these situations. The International Dysphagia Diet Standardisation Initiative Functional Diet Scale showed greater sensitivity than the FOIS to specific changes in diet. Most (>70%) respondents indicated enthusiasm for implementing the International Dysphagia Diet Standardisation Initiative Functional Diet Scale. This initial validation study suggests that the International Dysphagia Diet Standardisation Initiative Functional Diet Scale has strong consensual and criterion validity and can be used reliably by clinicians

  18. Optimal flight initiation distance.

    PubMed

    Cooper, William E; Frederick, William G

    2007-01-07

    Decisions regarding flight initiation distance have received scant theoretical attention. A graphical model by Ydenberg and Dill (1986. The economics of fleeing from predators. Adv. Stud. Behav. 16, 229-249) that has guided research for the past 20 years specifies when escape begins. In the model, a prey detects a predator, monitors its approach until costs of escape and of remaining are equal, and then flees. The distance between predator and prey when escape is initiated (approach distance = flight initiation distance) occurs where decreasing cost of remaining and increasing cost of fleeing intersect. We argue that prey fleeing as predicted cannot maximize fitness because the best prey can do is break even during an encounter. We develop two optimality models, one applying when all expected future contribution to fitness (residual reproductive value) is lost if the prey dies, the other when any fitness gained (increase in expected RRV) during the encounter is retained after death. Both models predict optimal flight initiation distance from initial expected fitness, benefits obtainable during encounters, costs of escaping, and probability of being killed. Predictions match extensively verified predictions of Ydenberg and Dill's (1986) model. Our main conclusion is that optimality models are preferable to break-even models because they permit fitness maximization, offer many new testable predictions, and allow assessment of prey decisions in many naturally occurring situations through modification of benefit, escape cost, and risk functions.

  19. Scottish Asthma Management Initiative.

    PubMed

    Hoskins, G; Neville, R G; McCowan, C; Smith, B; Clark, R A; Ricketts, I W

    2000-11-01

    To describe the development process of a system that links audit, research and patient care and to detail the lessons learned from establishing a Scotland wide asthma management initiative. Health Boards and practices throughout Scotland were invited to participate in an initiative which links review of care, guideline implementation, chronic disease management (CDM) approval and post-graduate education for doctors (PGEA) and nurses (PREP). Participating practices were given the materials to review 30 patients randomly selected from their asthma register. Health service resource use and drugs prescribed over a retrospective 12 month period were recorded for each patient using paper or electronic materials. All patients were invited for clinical assessment. A two-tier management system proved effective. Twelve of the 15 Scottish health authorities agreed to recognise the audit for automatic CDM approval although the negotiation process was prolonged; 566 practices from all parts of Scotland have expressed an interest in the initiative. Provision of distance learning material linked to PGEA accreditation is free to general practitioners (GP's) and is a useful incentive for participation. To date 42 GPs have completed the distance learning element. The Scottish Asthma Management Initiative has provided the opportunity for all sectors of the health service in Scotland to work together to explore innovative ways to improve the management and care of chronic disease. Participation in an initiative linked to guidelines, education and CDM approval is an excellent way to facilitate health professionals to improve care.

  20. AMCOM Hexavalent Chrome Free Initiatives

    DTIC Science & Technology

    2010-12-01

    AMCOM Hexavalent Chrome Free Initiatives 1 December 2010 SERDP-ESTCP Symposium Washington DC Mark Feathers AMCOM G-4 Environmental Division... Hexavalent Chrome Free Initiatives 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f...system environmental life cycle sustainability. G-4 is actively engaged in initiatives to reduce the use of hexavalent chrome used in materials and

  1. Rates of breastfeeding initiation among newborns.

    PubMed

    Maimburg, Rikke Damkjær

    2017-06-01

    Rates of breastfeeding initiation in hospitals with a tertiary neonatal intensive care unit are limited. A follow-up study with prospectively collected data in a Danish university hospital with approximately 5000 annual births was conducted. Between 1 February 2015 and 30 June 2015, 1939 newborns were enrolled in the study. Rates of frequencies for initiation of breastfeeding were calculated. High initiations rates for breastfeeding were found among term-born infants. Newborns of multiparous women had the highest initiation rate of 91.7% and newborns delivered by cesarean section had the lowest initiation rate of 73.3%. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Timing of Initiation of Maintenance Dialysis

    PubMed Central

    Wong, Susan P. Y.; Vig, Elizabeth K.; Taylor, Janelle S.; Burrows, Nilka R.; Liu, Chuan-Fen; Williams, Desmond E.; Hebert, Paul L.; O’Hare, Ann M.

    2016-01-01

    IMPORTANCE There is often considerable uncertainty about the optimal time to initiate maintenance dialysis in individual patients and little medical evidence to guide this decision. OBJECTIVE To gain a better understanding of the factors influencing the timing of initiation of dialysis in clinical practice. DESIGN, SETTING, AND PARTICIPANTS A qualitative analysis was conducted using the electronic medical records from the Department of Veterans Affairs (VA) of a national random sample of 1691 patients for whom the decision to initiate maintenance dialysis occurred in the VA between January 1, 2000, and December 31, 2009. Data analysis took place from June 1 to November 30, 2014. MAIN OUTCOMES AND MEASURES Central themes related to the timing of initiation of dialysis as documented in patients’ electronic medical records. RESULTS Of the 1691 patients, 1264 (74.7%) initiated dialysis as inpatients and 1228 (72.6%) initiated dialysis with a hemodialysis catheter. Cohort members met with a nephrologist during an outpatient clinic visit a median of 3 times (interquartile range, 0–6) in the year prior to initiation of dialysis. The mean (SD) estimated glomerular filtration rate at the time of initiation for cohort members was 10.4 (5.7) mL/min/1.73m2. The timing of initiation of dialysis reflected the complex interplay of at least 3 interrelated and dynamic processes. The first was physician practices, which ranged from practices intended to prepare patients for dialysis to those intended to forestall the need for dialysis by managing the signs and symptoms of uremia with medical interventions. The second process was sources of momentum. Initiation of dialysis was often precipitated by clinical events involving acute illness or medical procedures. In these settings, the imperative to treat often seemed to override patient choice. The third process was patient-physician dynamics. Interactions between patients and physicians were sometimes adversarial, and physician

  3. 75 FR 3820 - Broadband Initiatives Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... DEPARTMENT OF AGRICULTURE Rural Utilities Service RIN 0572-ZA01 Broadband Initiatives Program... policy and application procedures for the second round of funding under the broadband initiatives (the... Act) for the Broadband Initiatives Program (BIP) which provides loans, grants, and loan/grant...

  4. Initial data sets for the Schwarzschild spacetime

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gomez-Lobo, Alfonso Garcia-Parrado; Kroon, Juan A. Valiente; School of Mathematical Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS

    2007-01-15

    A characterization of initial data sets for the Schwarzschild spacetime is provided. This characterization is obtained by performing a 3+1 decomposition of a certain invariant characterization of the Schwarzschild spacetime given in terms of concomitants of the Weyl tensor. This procedure renders a set of necessary conditions--which can be written in terms of the electric and magnetic parts of the Weyl tensor and their concomitants--for an initial data set to be a Schwarzschild initial data set. Our approach also provides a formula for a static Killing initial data set candidate--a KID candidate. Sufficient conditions for an initial data set tomore » be a Schwarzschild initial data set are obtained by supplementing the necessary conditions with the requirement that the initial data set possesses a stationary Killing initial data set of the form given by our KID candidate. Thus, we obtain an algorithmic procedure of checking whether a given initial data set is Schwarzschildean or not.« less

  5. Measurement of breastfeeding initiation: Ethiopian mothers' perception about survey questions assessing early initiation of breastfeeding.

    PubMed

    Salasibew, Mihretab Melesse; Filteau, Suzanne; Marchant, Tanya

    2014-01-01

    Although breastfeeding is almost universal in Ethiopia, only 52% newborns benefited from early initiation in 2011. Early initiation is one of the recommended interventions for saving newborn lives but its potential seems not yet realized for Ethiopian newborns and there is a need for continued efforts to increase coverage. To do so, it is also relevant to focus on consistent and accurate reporting of coverage in early initiation. WHO recommends the question "how long after birth did you first put [name] to the breast?" in order to assess coverage in early initiation. It is designed to measure the time after birth when the mother attempted to initiate breastfeeding regardless of whether breast milk had arrived or not. However, it is unclear how mothers perceive this question and what their responses of time refer to. In this study, we assessed Ethiopian mothers' perception about the question assessing early initiation. Cognitive interviews were conducted between April and May 2013 with eligible mothers in Basona and Debrebirhan woredas (districts), 120 km away from Addis Ababa, Ethiopia. A total of 49 mothers, most from Basona (n = 36) and the rest from Debrebirhan woredas (n = 13) were interviewed. No probes or follow on questions were required for mothers to understand what the WHO recommended question was about. However, further probing was needed to ascertain what maternal responses of time refer to. Accordingly, mothers' response about the timing of early initiation was related to the first time the newborn received breast milk rather than their first attempt to initiate breastfeeding. In addition, considerable probing was required to approximate and code responses of time based on the WHO coding format because some mothers were unable to assess time in minutes or hours. The existing question is not adequate to identify intended attempts of mothers to initiate breastfeeding. We recommend revising the question as "how long after birth did you first put

  6. Identification of unique expression signatures and therapeutic targets in esophageal squamous cell carcinoma

    PubMed Central

    2012-01-01

    Background Esophageal squamous cell carcinoma (ESCC), the predominant histological subtype of esophageal cancer, is characterized by high mortality. Previous work identified important mRNA expression differences between normal and tumor cells; however, to date there are limited ex vivo studies examining expression changes occurring during normal esophageal squamous cell differentiation versus those associated with tumorigenesis. In this study, we used a unique tissue microdissection strategy and microarrays to measure gene expression profiles associated with cell differentiation versus tumorigenesis in twelve cases of patient-matched normal basal squamous epithelial cells (NB), normal differentiated squamous epithelium (ND), and squamous cell cancer. Class comparison and pathway analysis were used to compare NB versus tumor in a search for unique therapeutic targets. Results As a first step towards this goal, gene expression profiles and pathways were evaluated. Overall, ND expression patterns were markedly different from NB and tumor; whereas, tumor and NB were more closely related. Tumor showed a general decrease in differentially expressed genes relative to NB as opposed to ND that exhibited the opposite trend. FSH and IgG networks were most highly dysregulated in normal differentiation and tumorigenesis, respectively. DNA repair pathways were generally elevated in NB and tumor relative to ND indicating involvement in both normal and pathological growth. PDGF signaling pathway and 12 individual genes unique to the tumor/NB comparison were identified as therapeutic targets, and 10 associated ESCC gene-drug pairs were identified. We further examined the protein expression level and the distribution patterns of four genes: ODC1, POSTN, ASPA and IGF2BP3. Ultimately, three genes (ODC1, POSTN, ASPA) were verified to be dysregulated in the same pattern at both the mRNA and protein levels. Conclusions These data reveal insight into genes and molecular pathways mediating

  7. Somatic mutations of amino acid metabolism-related genes in gastric and colorectal cancers and their regional heterogeneity--a short report.

    PubMed

    Oh, Hye Rim; An, Chang Hyeok; Yoo, Nam Jin; Lee, Sug Hyung

    2014-12-01

    Metabolic reprogramming is an emerging topic in cancer research. However, genetic alterations in genes encoding enzymes involved in amino acid metabolism are largely unknown. The aim of this study was to explore whether genes known to be involved in amino acid metabolism are mutated in gastric cancer (GC) and/or colorectal cancer (CRC). Through a public database search, we found that a number of genes known to be involved in amino acid metabolism, i.e., AGXT, ALDH2, APIP, MTR, DNMT1, ASH1L, ASPA, CAD, DDC, GCDH, DLD, LAP3, MCEE and MUT, harbor mononucleotide repeats that may serve as mutation targets in cancers exhibiting microsatellite instability (MSI). We assessed these genes for the presence of the mutations in 79 GCs and 124 CRCs using single-strand conformation polymorphism (SSCP) and direct sequencing analyses. Using SSCP in conjunction with DNA sequencing we detected frameshift mutations in AGXT (17 cases), ALDH2 (3 cases), APIP (4 cases), MTR (5 cases), DNMT1 (1 case), ASH1L (1 case), ASPA (2 cases), CAD (2 cases), DDC (1 case), GCDH (3 cases), DLD (1 case), LAP3 (1 case), MCEE (5 cases) and MUT (1 case). These mutations were exclusively detected in MSI-high (MSI-H), and not in MSI-low or MSI-stable (MSI-L/MSS) cases. In addition, we analyzed 16 CRCs for the presence of intra-tumor heterogeneity (ITH) and found that two CRCs harbored regional ITH for GCDH frameshift mutations. Our data indicate that genes known to be involved in amino acid metabolism recurrently acquire somatic mutations in MSH-H GCs and MSH-H CRCs and that, in addition, mutation ITH does occur in at least some of these tumors. Together, these data suggest that metabolic reprogramming may play a role in the etiology of MSI-H GCs and CRCs. Our data also suggest that ultra-regional mutation analysis is required for a more comprehensive evaluation of the mutation status in these tumors.

  8. 'Crisis' and 'everyday' initiators: A qualitative study of coercion and agency in the context of methadone maintenance treatment initiation.

    PubMed

    Damon, Will; Small, Will; Anderson, Solanna; Maher, Lisa; Wood, Evan; Kerr, Thomas; McNeil, Ryan

    2017-03-01

    Patient attrition is common among people enrolled in methadone maintenance treatment (MMT) programs and most pronounced during the first year of treatment. However, the experiences of patients initiating MMT have been overlooked in the literature. This study explores experiences of MMT initiation among MMT patients, focusing on contextual influences on MMT initiation and perceptions of MMT and their subsequent influence on treatment retention. Semi-structured qualitative interviews were conducted with 39 MMT patients in Vancouver, Canada. Individuals reporting enrolment in MMT were recruited from within two ongoing cohort studies comprised of people who use drugs. Interview transcripts were analysed using an inductive and iterative approach. Two groups of MMT initiators were identified: (i) 'crisis initiators' prescribed methadone following critical transition events, such as incarceration or pregnancy; and (ii) 'everyday initiators' enrolled in MMT as part of routine healthcare utilisation. While most 'crisis initiators' and some 'everyday initiators' described experiencing coercion during MMT initiation, 'crisis initiators' were further subjected to the coercive leveraging of their vulnerability to motivate 'consent' for MMT. 'Crisis initiators' developed negative views towards MMT and were more likely to discontinue treatment. Long-standing patient-provider relationships and open dialogue were associated with more positive views regarding MMT, regardless of the circumstances of initiation. Findings underscore the need for clear and effective communication regarding treatment regimens and expectations during MMT initiation. Furthermore, training in trauma-informed care may help reduce perceptions of coercion and rates of early treatment termination. [Damon W, Small W, Anderson S, Maher L, Wood E, Kerr T, McNeil R. Crisis' and 'everyday' initiators: A qualitative study of coercion and agency in the context of methadone maintenance treatment initiation. Drug

  9. 30 CFR 56.6308 - Initiation systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Initiation systems. 56.6308 Section 56.6308 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Initiation systems. Initiation systems shall be used in accordance with the manufacturer's instructions. ...

  10. 30 CFR 56.6308 - Initiation systems.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Initiation systems. 56.6308 Section 56.6308 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Initiation systems. Initiation systems shall be used in accordance with the manufacturer's instructions. ...

  11. 30 CFR 56.6308 - Initiation systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Initiation systems. 56.6308 Section 56.6308 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Initiation systems. Initiation systems shall be used in accordance with the manufacturer's instructions. ...

  12. Initiation and structures of gaseous detonation

    NASA Astrophysics Data System (ADS)

    Vasil'ev, A. A.; Vasiliev, V. A.

    2018-03-01

    The analysis of the initiation of a detonation wave (DW) and the emergence of a multi-front structure of the DW-front are presented. It is shown that the structure of the DW arises spontaneously at the stage of a strong overdriven of the wave. The hypothesis of the gradual enhancement of small perturbations on an initially smooth initiating blast wave, traditionally used in the numerical simulation of multi-front detonation, does not agree with the experimental data. The instability of the DW is due to the chemical energy release of the combustible mixture Q. A technique for determining the Q-value of mixture was proposed, based on reconstruction of the trajectory of the expanding wave from the position of the strong explosion model. The wave trajectory at the critical initiation of a multifront detonation in a combustible mixture is compared with the trajectory of an explosive wave from the same initiator in an inert mixture whose gas-dynamic parameters are equivalent to the parameters of the combustible mixture. The energy release of a mixture is defined as the difference in the joint energy release of the initiator and the fuel mixture during the critical initiation and energy release of the initiator when the blast wave is excited in an inert mixture. Observable deviations of the experimental profile of Q from existing model representations were found.

  13. Sox2 is translationally activated by eukaryotic initiation factor 4E in human glioma-initiating cells

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ge, Yuqing; Zhou, Fengbiao; Chen, Hong

    2010-07-09

    Sox2, a master transcription factor, contributes to the generation of induced pluripotent stem cells and plays significant roles in sustaining the self-renewal of neural stem cells and glioma-initiating cells. Understanding the functional differences of Sox2 between glioma-initiating cells and normal neural stem cells would contribute to therapeutic approach for treatment of brain tumors. Here, we first demonstrated that Sox2 could contribute to the self-renewal and proliferation of glioma-initiating cells. The following experiments showed that Sox2 was activated at translational level in a subset of human glioma-initiating cells compared with the normal neural stem cells. Further investigation revealed there was amore » positive correlation between Sox2 and eukaryotic initiation factor 4E (eIF4E) in glioma tissues. Down-regulation of eIF4E decreased Sox2 protein level without altering its mRNA level in glioma-initiating cells, indicating that Sox2 was activated by eIF4E at translational level. Furthermore, eIF4E was presumed to regulate the expression of Sox2 by its 5' untranslated region (5' UTR) sequence. Our results suggest that the eIF4E-Sox2 axis is a novel mechanism of unregulated self-renewal of glioma-initiating cells, providing a potential therapeutic target for glioma.« less

  14. 30 CFR 57.6308 - Initiation systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Initiation systems. 57.6308 Section 57.6308 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Transportation-Surface and Underground § 57.6308 Initiation systems. Initiation systems shall be used in...

  15. 30 CFR 57.6308 - Initiation systems.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Initiation systems. 57.6308 Section 57.6308 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Transportation-Surface and Underground § 57.6308 Initiation systems. Initiation systems shall be used in...

  16. 30 CFR 57.6308 - Initiation systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Initiation systems. 57.6308 Section 57.6308 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Transportation-Surface and Underground § 57.6308 Initiation systems. Initiation systems shall be used in...

  17. Framework for Evaluating Educational Systemic Initiatives.

    ERIC Educational Resources Information Center

    Ikegulu, T. Nelson

    This paper describes the implementation of the Holistic Systemic Evaluation (HSE), a component of an Education Systemic Initiative's strategic management. The HSE provides general guidance for the implementation and continual improvement of an Education Systemic Initiative Reform (ESIR). The implementation of the education system initiative plan:…

  18. Electrical initiation of an energetic nanolaminate film

    DOEpatents

    Tringe, Joseph W.; Gash, Alexander E.; Barbee, Jr., Troy W.

    2010-03-30

    A heating apparatus comprising an energetic nanolaminate film that produces heat when initiated, a power source that provides an electric current, and a control that initiates the energetic nanolaminate film by directing the electric current to the energetic nanolaminate film and joule heating the energetic nanolaminate film to an initiation temperature. Also a method of heating comprising providing an energetic nanolaminate film that produces heat when initiated, and initiating the energetic nanolaminate film by directing an electric current to the energetic nanolaminate film and joule heating the energetic nanolaminate film to an initiation temperature.

  19. National Strategic Computing Initiative Strategic Plan

    DTIC Science & Technology

    2016-07-01

    23 A.6 National Nanotechnology Initiative...Initiative: https://www.nitrd.gov/nitrdgroups/index.php?title=Big_Data_(BD_SSG)  National Nanotechnology Initiative: http://www.nano.gov  Precision...computing. While not limited to neuromorphic technologies, the National Nanotechnology Initiative’s first Grand Challenge seeks to achieve brain

  20. Initiation of Coitus in Early Adolescence.

    ERIC Educational Resources Information Center

    Udry, J. Richard; Billy, John O. G.

    1987-01-01

    White males' initiation of coitus in early adolescence is dominated by motivational hormone effects and social attractiveness. White females' initiation of coitus is dominated by the effects of social controls. Black females' initiation of coitus is dominated by their level of pubertal development, an attractiveness variable. (Author/BJV)

  1. 40 CFR 610.12 - Program initiative.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Program initiative. 610.12 Section 610... RETROFIT DEVICES Test Procedures and Evaluation Criteria General Provisions § 610.12 Program initiative. A... being marketed may be inadequate, (b) At the EPA Administrator's initiative, or (c) Upon the application...

  2. 40 CFR 35.2212 - Project initiation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Project initiation. 35.2212 Section 35... STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2212 Project initiation. (a) The grantee shall expeditiously initiate and complete the project, in accordance with the project...

  3. 40 CFR 35.2212 - Project initiation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Project initiation. 35.2212 Section 35... STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2212 Project initiation. (a) The grantee shall expeditiously initiate and complete the project, in accordance with the project...

  4. 40 CFR 35.2212 - Project initiation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Project initiation. 35.2212 Section 35... STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2212 Project initiation. (a) The grantee shall expeditiously initiate and complete the project, in accordance with the project...

  5. 40 CFR 35.2212 - Project initiation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Project initiation. 35.2212 Section 35... STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2212 Project initiation. (a) The grantee shall expeditiously initiate and complete the project, in accordance with the project...

  6. 40 CFR 35.2212 - Project initiation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Project initiation. 35.2212 Section 35... STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works § 35.2212 Project initiation. (a) The grantee shall expeditiously initiate and complete the project, in accordance with the project...

  7. Initiating Smokeless Tobacco Use across Reproductive Stages.

    PubMed

    Begum, Shahina; Schensul, Jean J; Nair, Saritha; Donta, Balaiah

    2015-01-01

    The use of smokeless tobacco (SLT) among women is increasing in India, especially among those with limited education and resources. Preventing the initiation of SLT among women is critical since it has known negative consequences for oral and reproductive health. Most research on tobacco initiation in India focuses on adolescents. This paper addresses the unrecognized issues of post marital initiation among women of reproductive age, highlighting the importance of reproductive stages in women's tobacco initiation. The objective is to examine the correlates of SLT initiation among low income women in Mumbai from pre-marriage through early marriage, first pregnancy and beyond, using case examples to illustrate initiation during each of these stages. In 2011-2012, cross-sectional community level survey data were collected from a representative sample of 409 daily SLT-using married women aged 18-40 years in a low income community in Mumbai. Information on socio-demographics, initiation by reproductive stage, types of tobacco use, childhood exposure to tobacco, learning to use, and initiation influences and reasons were collected through a researcher-administered survey. Univariate and bivariate analysis assessed factors influencing initiation of SLT use by reproductive stage. In addition 42 narratives of tobacco use were collected from a purposive sample of pregnant and non-pregnant married women addressing the same questions in detail. Narratives were transcribed, translated, and coded for key concepts including initiation of tobacco use. Thirty-two percent of women initiated SLT use before marriage, 44% initiated after marriage but before pregnancy, 18.1% initiated during their first pregnancy and the remainder started after their first pregnancy. Mean age of marriage among women in this study was 16 years. Younger women (i.e. age at time of the interview of less than 30 years) were 0.47 [95% CI (0.32, 0.87)] percent less likely to initiate after marriage than women

  8. 24 CFR 125.201 - Administrative Enforcement Initiative.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Initiative. 125.201 Section 125.201 Housing and Urban Development Regulations Relating to Housing and Urban... FAIR HOUSING FAIR HOUSING INITIATIVES PROGRAM § 125.201 Administrative Enforcement Initiative. The Administrative Enforcement Initiative provides funding to State and local fair housing agencies administering...

  9. 10 CFR 824.13 - Initial decision.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Initial decision. 824.13 Section 824.13 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY VIOLATIONS § 824.13 Initial decision. (a) The Hearing Officer shall issue an initial decision as soon as...

  10. 45 CFR 79.37 - Initial decision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Initial decision. 79.37 Section 79.37 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.37 Initial decision. (a) The ALJ shall issue an initial decision based only on the record, which...

  11. 75 FR 12433 - National Export Initiative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... Order 13534 of March 11, 2010 National Export Initiative By the authority vested in me as President by... performance will, in turn, create good high-paying jobs. The National Export Initiative (NEI) shall be an Administration initiative to improve conditions that directly affect the private sector's ability to export. The...

  12. 19 CFR 351.201 - Self-initiation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Self-initiation. 351.201 Section 351.201 Customs... Antidumping and Countervailing Duty Procedures § 351.201 Self-initiation. (a) Introduction. Antidumping and countervailing duty investigations may be initiated as the result of a petition filed by a domestic interested...

  13. 6 CFR 13.37 - Initial Decision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Initial Decision. 13.37 Section 13.37 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.37 Initial Decision. (a) The ALJ will issue an Initial Decision based only on the record, which will contain...

  14. 24 CFR 125.401 - Private Enforcement Initiative.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Private Enforcement Initiative. 125... FAIR HOUSING FAIR HOUSING INITIATIVES PROGRAM § 125.401 Private Enforcement Initiative. (a) The Private Enforcement Initiative provides funding on a single-year or multi-year basis, to investigate violations and...

  15. The Dynamics of Initiative in Communication Networks.

    PubMed

    Mollgaard, Anders; Mathiesen, Joachim

    2016-01-01

    Human social interaction is often intermittent. Two acquainted persons can have extended periods without social interaction punctuated by periods of repeated interaction. In this case, the repeated interaction can be characterized by a seed initiative by either of the persons and a number of follow-up interactions. The tendency to initiate social interaction plays an important role in the formation of social networks and is in general not symmetric between persons. In this paper, we study the dynamics of initiative by analysing and modeling a detailed call and text message network sampled from a group of 700 individuals. We show that in an average relationship between two individuals, one part is almost twice as likely to initiate communication compared to the other part. The asymmetry has social consequences and ultimately might lead to the discontinuation of a relationship. We explain the observed asymmetry by a positive feedback mechanism where individuals already taking initiative are more likely to take initiative in the future. In general, people with many initiatives receive attention from a broader spectrum of friends than people with few initiatives. Lastly, we compare the likelihood of taking initiative with the basic personality traits of the five factor model.

  16. Initiator Status and the Divorce Transition.

    ERIC Educational Resources Information Center

    Buehler, Cheryl

    1987-01-01

    Examined effect of initiator status on well-being and stress in 80 divorced parents at 6 to 12 (T1) and 18 to 24 (T2) months after the divorce. Found that initiators and noninitiators shared similar emotional responses to divorce but that initiators reported more change, stress, and personal growth at (T1), while noninitiators reported higher…

  17. Initiation of parturition in humans.

    PubMed

    Drover, J W; Casper, R F

    1983-02-15

    The mechanism by which parturition is initiated in humans is largely unknown. The placenta and fetal membranes appear to play the major role in the initiation of labour, and the fetus may influence the timing of labour. Clinical observations and experiments with animals have revealed that placental neuropeptides may be able to control steroid metabolism and trigger the onset of labour, while the fetus may be able to interact with such events to initiate parturition at an appropriate time. However, further study is needed to determine the role of placental releasing factors and glycoprotein hormones and their ability to control placental steroid metabolism.

  18. 10 CFR 75.32 - Initial inventory report.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Initial inventory report. 75.32 Section 75.32 Energy... AGREEMENT Reports § 75.32 Initial inventory report. (a) The initial inventory reporting date shall be the... inventory report is required. (b) The initial inventory report, to be submitted to the Commission as...

  19. Next generation initiation techniques

    NASA Technical Reports Server (NTRS)

    Warner, Tom; Derber, John; Zupanski, Milija; Cohn, Steve; Verlinde, Hans

    1993-01-01

    Four-dimensional data assimilation strategies can generally be classified as either current or next generation, depending upon whether they are used operationally or not. Current-generation data-assimilation techniques are those that are presently used routinely in operational-forecasting or research applications. They can be classified into the following categories: intermittent assimilation, Newtonian relaxation, and physical initialization. It should be noted that these techniques are the subject of continued research, and their improvement will parallel the development of next generation techniques described by the other speakers. Next generation assimilation techniques are those that are under development but are not yet used operationally. Most of these procedures are derived from control theory or variational methods and primarily represent continuous assimilation approaches, in which the data and model dynamics are 'fitted' to each other in an optimal way. Another 'next generation' category is the initialization of convective-scale models. Intermittent assimilation systems use an objective analysis to combine all observations within a time window that is centered on the analysis time. Continuous first-generation assimilation systems are usually based on the Newtonian-relaxation or 'nudging' techniques. Physical initialization procedures generally involve the use of standard or nonstandard data to force some physical process in the model during an assimilation period. Under the topic of next-generation assimilation techniques, variational approaches are currently being actively developed. Variational approaches seek to minimize a cost or penalty function which measures a model's fit to observations, background fields and other imposed constraints. Alternatively, the Kalman filter technique, which is also under investigation as a data assimilation procedure for numerical weather prediction, can yield acceptable initial conditions for mesoscale models. The

  20. Cigarette advertising and teen smoking initiation.

    PubMed

    Hanewinkel, Reiner; Isensee, Barbara; Sargent, James D; Morgenstern, Matthis

    2011-02-01

    To test the specificity of the association between cigarette advertising and adolescent smoking initiation. A longitudinal survey of 2102 adolescents, aged 10 to 17 years at baseline, who never smoked was conducted by using masked images of 6 cigarette advertisements and 8 other commercial products with all brand information digitally removed. The exposure variable was a combination of contact frequency and cued recall of brands for cigarette and other advertisements. Multilevel mixed-effects Poisson regressions were used to assess smoking initiation 9 months after the baseline assessment as a function of cigarette-advertisement exposure, other advertisement exposure, and baseline covariates. Thirteen percent (n = 277) of students initiated smoking during the observation period. Although the incidence of trying smoking was associated with increased exposure to cigarette advertisements (10% in the low, 12% in the medium, and 19% in the high cigarette-advertisement exposure tertile initiated smoking), exposure to other advertisements did not predict smoking initiation. Compared with low exposure to cigarette advertisements, high exposure remained a significant predictor of adolescent smoking initiation after controlling for baseline covariates (adjusted relative risk: 1.46 [95% confidence interval: 1.08-1.97]; P < .05). Our results support the notion of a content-related effect of cigarette advertisements and underlines the specificity of the relationship between tobacco marketing and teen smoking; exposure to cigarette advertisements, but not other advertisements, is associated with smoking initiation.

  1. Global Methane Initiative

    EPA Pesticide Factsheets

    The Global Methane Initiative promotes cost-effective, near-term methane recovery through partnerships between developed and developing countries, with participation from the private sector, development banks, and nongovernmental organizations.

  2. Blood donor screening for West Nile virus (WNV) revealed acute Usutu virus (USUV) infection, Germany, September 2016.

    PubMed

    Cadar, Daniel; Maier, Philipp; Müller, Susanne; Kress, Julia; Chudy, Michael; Bialonski, Alexandra; Schlaphof, Alexander; Jansen, Stephanie; Jöst, Hanna; Tannich, Egbert; Runkel, Stefan; Hitzler, Walter E; Hutschenreuter, Gabriele; Wessiepe, Martina; Schmidt-Chanasit, Jonas

    2017-04-06

    Between 1 June and 31 December 2016, 13,023 blood donations from the University Hospital Aachen in Germany were routinely screened for West Nile virus (WNV) RNA using the cobas TaqScreen WNV Test. On 28 September 2016, one blood donor was tested positive. Subsequent analysis revealed an acute Usutu virus (USUV) infection. During the ongoing USUV epizootics in Germany, blood transfusion services, public health authorities and clinicians should be aware of increased human USUV infections. This article is copyright of The Authors, 2017.

  3. Explosive laser light initiation of propellants

    DOEpatents

    Piltch, Martin S.

    1993-01-01

    A improved initiator for artillery shell using an explosively generated laser light to uniformly initiate the propellent. A small quantity of a high explosive, when detonated, creates a high pressure and temperature, causing the surrounding noble gas to fluoresce. This fluorescence is directed into a lasing material, which lases, and directs laser light into a cavity in the propellant, uniformly initiating the propellant.

  4. Explosive laser light initiation of propellants

    DOEpatents

    Piltch, M.S.

    1993-05-18

    A improved initiator for artillery shell using an explosively generated laser light to uniformly initiate the propellent. A small quantity of a high explosive, when detonated, creates a high pressure and temperature, causing the surrounding noble gas to fluoresce. This fluorescence is directed into a lasing material, which lases, and directs laser light into a cavity in the propellant, uniformly initiating the propellant.

  5. Fayette County Better Buildings Initiative

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Capella, Arthur

    The Fayette County Better Buildings Initiative represented a comprehensive and collaborative approach to promoting and implementing energy efficiency improvements. The initiative was designed to focus on implementing energy efficiency improvements in residential units, while simultaneously supporting general marketing of the benefits of implementing energy efficiency measures. The ultimate goal of Fayette County’s Better Buildings Initiative was to implement a total of 1,067 residential energy efficiency retrofits with a minimum 15% estimated energy efficiency savings per unit. Program partners included: United States Department of Energy, Allegheny Power, and Private Industry Council of Westmoreland-Fayette, Fayette County Redevelopment Authority, and various local partners.more » The program was open to any Fayette County residents who own their home and meet the prequalifying conditions. The level of assistance offered depended upon household income and commitment to undergo a BPI – Certified Audit and implement energy efficiency measures, which aimed to result in at least a 15% reduction in energy usage. The initiative was designed to focus on implementing energy efficiency improvements in residential units, while simultaneously supporting general marketing of the benefits of implementing energy efficiency measures. Additionally, the program had components that involved recruitment and training for employment of persons in the energy sector (green jobs), as well as marketing and implementation of a commercial or community facilities component. The residential component of Fayette County’s Better Buildings Initiative involved a comprehensive approach, providing assistance to low- moderate- and market-rate homeowners. The initiative will also coordinate activities with local utility providers to further incentivize energy efficiency improvements among qualifying homeowners. The commercial component of Fayette County’s Better Building Initiative involved

  6. RAS Initiative - Events

    Cancer.gov

    The NCI RAS Initiative has organized multiple events with outside experts to discuss how the latest scientific and technological breakthroughs can be applied to discover vulnerabilities in RAS-driven cancers.

  7. Comprehensive School Safety Initiative Report

    ERIC Educational Resources Information Center

    National Institute of Justice, 2014

    2014-01-01

    The National Institute of Justice (NIJ) developed the Comprehensive School Safety Initiative in consultation with federal partners and Congress. It is a research-focused initiative designed to increase the safety of schools nationwide through the development of knowledge regarding the most effective and sustainable school safety interventions and…

  8. Origin and initiation mechanisms of neuroblastoma.

    PubMed

    Tsubota, Shoma; Kadomatsu, Kenji

    2018-05-01

    Neuroblastoma is an embryonal malignancy that affects normal development of the adrenal medulla and paravertebral sympathetic ganglia in early childhood. Extensive studies have revealed the molecular characteristics of human neuroblastomas, including abnormalities at genome, epigenome and transcriptome levels. However, neuroblastoma initiation mechanisms and even its origin are long-standing mysteries. In this review article, we summarize the current knowledge about normal development of putative neuroblastoma sources, namely sympathoadrenal lineage of neural crest cells and Schwann cell precursors that were recently identified as the source of adrenal chromaffin cells. A plausible origin of enigmatic stage 4S neuroblastoma is also discussed. With regard to the initiation mechanisms, we review genetic abnormalities in neuroblastomas and their possible association to initiation mechanisms. We also summarize evidences of neuroblastoma initiation observed in genetically engineered animal models, in which epigenetic alterations were involved, including transcriptomic upregulation by N-Myc and downregulation by polycomb repressive complex 2. Finally, several in vitro experimental methods are proposed that hopefully will accelerate our comprehension of neuroblastoma initiation. Thus, this review summarizes the state-of-the-art knowledge about the mechanisms of neuroblastoma initiation, which is critical for developing new strategies to cure children with neuroblastoma.

  9. The RAS Initiative

    Cancer.gov

    NCI established the RAS Initiative to explore innovative approaches for attacking the proteins encoded by mutant forms of RAS genes and to ultimately create effective, new therapies for RAS-related cancers.

  10. Adaptable Miniature Initiation System Technology (AMIST)

    DTIC Science & Technology

    2006-09-01

    exploding foil initiator ( EFI ) to detonate an insensitive secondary explosive. The in-line (no moving parts) nature of EFIs increases their...reliability over out-of-line initiation systems. Likewise, EFI fire points increase the safety factor for two main reasons: (1) firing an EFI requires a very...AFRL-MN-EG-TP-2006-7410 ADAPTABLE MINIATURE INITIATION SYSTEM TECHNOLOGY (AMIST) Kenneth Bradley Chris Martin Ed Wild Air

  11. 29 CFR 4211.36 - Modifications to the determination of initial liabilities, the amortization of initial...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., the amortization of initial liabilities, and the allocation fraction. 4211.36 Section 4211.36 Labor... initial liabilities, and the allocation fraction. (a) General rule. A plan using any of the allocation... participation under their prior plans. An amendment under this paragraph must include an allocation fraction...

  12. Career Technical Education Pathways Initiative

    ERIC Educational Resources Information Center

    California Community Colleges, Chancellor's Office, 2013

    2013-01-01

    California's education system--the largest in the United States--is an essential resource for ensuring strong economic growth in the state. The Career Technical Education Pathways Initiative (referred to as the Initiative in this report), which became law in 2005, brings together community colleges, K-12 school districts, employers, organized…

  13. Secretary's Initiative on Adult Literacy.

    ERIC Educational Resources Information Center

    Vines, Diane Welch

    The National Adult Literacy Initiative calls for a collaborative effort among the public, private, voluntary, and military sectors to address more effectively illiteracy through adult education. One of the first points in the initiative calls for continued educational services funded by the federal government and administered by the states. Other…

  14. Pathways between Ecstasy Initiation and Other Drug Use

    PubMed Central

    Martins, Silvia S.; Ghandour, Lilian A.; Chilcoat, Howard D.

    2007-01-01

    This study aims to shed light on drug use pathways associated with ecstasy use initiation. Data from 54,573 respondents aged 12-21 years old from the 2002-2003 National Survey on Drug Use and Health (NSDUH) public use data files were analyzed via Cox proportional hazards models with time-dependent covariates. Our findings showed that marijuana, cocaine, and heroin were significant independent predictors of subsequent ecstasy use. Earlier ecstasy initiation was significantly associated with subsequent other illegal drug initiation (marijuana, cocaine and heroin). The strength of the association was greater for the pathway from earlier marijuana initiation to subsequent ecstasy initiation as compared to the pathway in the opposite direction. The pathway from earlier ecstasy initiation to subsequent cocaine and heroin initiation was also stronger as compared to pathways in the opposite directions. Pathways between ecstasy initiation and marijuana, cocaine and heroin initiation seem to be independent of the association between drug use and psychiatric symptoms/deviant behaviors. Ecstasy initiation seems to play a role in the subsequent initiation of cocaine and heroin. PMID:17174036

  15. Collaborative Procurement Initiative

    EPA Pesticide Factsheets

    GPP's Clean Energy Collaborative Procurement Initiative provides a platform for deploying clean energy technologies across multiple government and educational organizations for maximum impact on installed solar system capacity and local economic activity.

  16. Research Programs & Initiatives

    Cancer.gov

    CGH develops international initiatives and collaborates with other NCI divisions, NCI-designated Cancer Centers, and other countries to support cancer control planning, encourage capacity building, and support cancer research and research networks.

  17. PESP Landscaping Initiative

    EPA Pesticide Factsheets

    Landscaping practices can positively or negatively affect local environments and human health. The Landscaping Initiative seeks to enhance benefits of landscaping while reducing need for pesticides, fertilizers, etc., by working with partners.

  18. Flight demonstration of laser diode initiated ordnance

    NASA Technical Reports Server (NTRS)

    Boucher, Craig J.; Schulze, Norman R.

    1995-01-01

    A program has been initiated by NASA Headquarters to validate laser initiated ordnance in flight applications. The primary program goal is to bring together a team of government and industry members to develop a laser initiated ordnance system having the test and analysis pedigree to be flown on launch vehicles. The culmination of this effort was a flight of the Pegasus launch vehicle which had two fin rockets initiated by this laser system. In addition, a laser initiated ordnance squib was fired into a pressure bomb during thrusting flight. The complete ordnance system comprising a laser diode firing unit, fiber optic cable assembly, laser initiated detonator, and laser initiated squib was designed and built by The Ensign Bickford Company. The hardware was tested to the requirements of the Pegasus launch vehicle and integrated into the vehicle by The Ensign Bickford Company and the Orbital Sciences Corporation. Discussions include initial program concept, contract implementation, team member responsibilities, analysis results, vehicle integration, safing architecture, ordnance interfaces, mission timeline and telemetry data. A complete system description, summary of the analyses, the qualification test results, and the results of flight are included.

  19. MAGI: many-component galaxy initializer

    NASA Astrophysics Data System (ADS)

    Miki, Yohei; Umemura, Masayuki

    2018-04-01

    Providing initial conditions is an essential procedure for numerical simulations of galaxies. The initial conditions for idealized individual galaxies in N-body simulations should resemble observed galaxies and be dynamically stable for time-scales much longer than their characteristic dynamical times. However, generating a galaxy model ab initio as a system in dynamical equilibrium is a difficult task, since a galaxy contains several components, including a bulge, disc, and halo. Moreover, it is desirable that the initial-condition generator be fast and easy to use. We have now developed an initial-condition generator for galactic N-body simulations that satisfies these requirements. The developed generator adopts a distribution-function-based method, and it supports various kinds of density models, including custom-tabulated inputs and the presence of more than one disc. We tested the dynamical stability of systems generated by our code, representing early- and late-type galaxies, with N = 2097 152 and 8388 608 particles, respectively, and we found that the model galaxies maintain their initial distributions for at least 1 Gyr. The execution times required to generate the two models were 8.5 and 221.7 seconds, respectively, which is negligible compared to typical execution times for N-body simulations. The code is provided as open-source software and is publicly and freely available at https://bitbucket.org/ymiki/magi.

  20. Nebraska: Early Head Start Initiative

    ERIC Educational Resources Information Center

    Center for Law and Social Policy, Inc. (CLASP), 2012

    2012-01-01

    Since 1999, Nebraska's Early Head Start Infant/Toddler Quality Initiative has supported Early Head Start (EHS) and community child care partnerships to improve the quality and professionalism of infant and toddler care. EHS programs apply to receive funding to establish partnerships with center-based or home-based child care.The initiative has…

  1. Two black hole initial data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leski, Szymon

    2005-06-15

    The Misner initial data are a standard example of time-symmetric initial data with two apparent horizons. Compact formulae describing such data are presented in the cases of equal or nonequal masses (i.e. isometric or nonisometric horizons). The interaction energy in the 'Schwarzschild + test-particle' limit of the Misner data is analyzed.

  2. Review Of Internet Health Information Quality Initiatives

    PubMed Central

    Dzenowagis, Joan

    2001-01-01

    Background The massive growth of health information on the Internet; the global nature of the Internet; the seismic shift taking place in the relationships of various actors in this arena, and the absence of real protection from harm for citizens who use the Internet for health purposes are seen to be real problems. One response to many of these problems has been the burgeoning output of codes of conduct by numerous organizations trying to address quality of health information. Objectives Review the major self-regulatory initiatives in the English-speaking world to develop quality and ethical standards for health information on the Internet. Compare and analyze the approaches taken by the different initiatives. Clarify the issues around the development and enforcement of standards. Methods Quality initiatives selected meet one or more of the following criteria: Self-regulatory. A reasonable constituency. Diversity (eg, of philosophy, approach and process)-to achieve balance and wide representation, and to illustrate and compare different approaches. Historic value. A wider reach than a national audience, except when its reach is a significant sector of the Internet health information industry. The initiatives were compared in 3 ways: (1) Analysis and comparison of: key concepts, mechanism, or approach. Analysis of: the obligations that a provider has to meet to comply with the given initiative, the intended beneficiaries of that initiative, and the burdens imposed on different actors. These burdens are described in terms of their effect on the long-term sustainability and maintenance of the initiative by its developers. Analysis of the enforcement mechanisms. (2) Analysis and comparison by type of sponsoring organization, the reach of the initiative, and the sources of funding of the initiative or the sponsoring organization. (3) How the various initiatives fall under 1 of 3 key mechanisms and comparison of the advantages and disadvantages of these key mechanisms

  3. Modeling Initiation in Exploding Bridgewire Detonators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hrousis, C A

    2005-05-18

    One- and two-dimensional models of initiation in detonators are being developed for the purpose of evaluating the performance of aged and modified detonator designs. The models focus on accurate description of the initiator, whether it be an EBW (exploding bridgewire) that directly initiates a high explosive powder or an EBF (exploding bridgefoil) that sends an inert flyer into a dense HE pellet. The explosion of the initiator is simulated using detailed MHD equations of state as opposed to specific action-based phenomenological descriptions. The HE is modeled using the best available JWL equations of state. Results to date have been promising,more » however, work is still in progress.« less

  4. Symbolic significance of initials on longevity.

    PubMed

    Abel, Ernest L; Kruger, Michael L

    2007-02-01

    The longevities of deceased major league baseball players who died prior to 1950 (N=3835) and whose initials formed acronyms, words, or names with "positive" or "negative" affect, as rated a priori by two judges, were compared with those for a group of neutral controls matched for birth year and career length, using the Berkeley standardized mortality tables. Players (n=11) with positive initials, e.g., A.C.E., lived a mean of 13 years longer than players (n=30) with negative initials, e.g., D.E.D., or players with neutral initials (n=864). These results corroborated a previous study and suggest positive name symbols are associated with increased longevity in this sample.

  5. A Review of Empirical Analyses of Disinvestment Initiatives.

    PubMed

    Chambers, James D; Salem, Mark N; D'Cruz, Brittany N; Subedi, Prasun; Kamal-Bahl, Sachin J; Neumann, Peter J

    Disinvesting in low-value health care services provides opportunities for investment in higher value care and thus an increase in health care efficiency. To identify international experience with disinvestment initiatives and to review empirical analyses of disinvestment initiatives. We performed a literature search using the PubMed database to identify international experience with disinvestment initiatives. We also reviewed empirical analyses of disinvestment initiatives. We identified 26 unique disinvestment initiatives implemented across 11 countries. Nineteen addressed multiple intervention types, six addressed only drugs, and one addressed only devices. We reviewed 18 empirical analyses of disinvestment initiatives: 7 reported that the initiative was successful, 8 reported that the initiative was unsuccessful, and 3 reported that findings were mixed; that is, the study considered multiple services and reported a decrease in the use of some but not others. Thirty-seven low-value services were evaluated across the 18 empirical analyses, for 14 (38%) of which the disinvestment initiative led to a decline in use. Six of the seven studies that reported the disinvestment initiative to be successful included an attempt to promote the disinvestment initiative among participating clinicians. The success of disinvestment initiatives has been mixed, with fewer than half the identified empirical studies reporting that use of the low-value service was reduced. Our findings suggest that promotion of the disinvestment initiative among clinicians is a key component to the success of the disinvestment initiative. Copyright © 2017 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  6. Women's Health Initiative (WHI) Background and Overview

    MedlinePlus

    ... The Science / Women’s Health Initiative (WHI) Women’s Health Initiative (WHI) Project began 1991 Point of contact Shari ... the goal of the WHI? The Women's Health Initiative (WHI), sponsored by the National Heart, Lung, and ...

  7. The ARL Scholars Portal Initiative.

    ERIC Educational Resources Information Center

    Jackson, Mary E.

    2002-01-01

    Describes an initiative of the Association of Research Libraries (ARL), the Scholars Portal Initiative, a three-year collaborative effort which seeks to provide tools for an academic community to have a single point of access on the Web to find high-quality information resources and to deliver the information and related services directly to the…

  8. Consequences of BBPs Affordability Initiative

    DTIC Science & Technology

    2016-04-30

    qÜáêíÉÉåíÜ=^ååì~ä= ^Åèìáëáíáçå=oÉëÉ~êÅÜ= póãéçëáìã= tÉÇåÉëÇ~ó=pÉëëáçåë= sçäìãÉ=f= = Consequences of BBP’s Affordability Initiative Gregory Davis , Research...Initiative Gregory Davis , Research Staff Member, Institute for Defense Analyses Lawrence Goeller, Defense Acquisition Analyst, Institute for Defense...Consequences of BBP’s Affordability Initiative Gregory Davis —has been at the Institute for Defense Analyses (IDA) since 2006, conducting research on as

  9. Steps towards equal gender representation: TANDEMplusIDEA - an international mentoring and personal development scheme for female scientists

    NASA Astrophysics Data System (ADS)

    Schaefli, Bettina; Breuer, Elke

    2010-05-01

    TANDEMplusIDEA was a European mentoring programme conducted by the technical universities RWTH Aachen, Imperial College London, ETH Zurich and TU Delft between 2007 and 2010 to achieve more gender equality in science. Given the continuing underrepresentation of women in science and technology and the well-known structural and systematic disadvantages in male-dominated scientific cultures, the main goal of this programme was to promote excellent female scientists through a high-level professional and personal development programme. Based on the mentoring concept of the RWTH Aachen, TANDEMplusIDEA was the first mentoring programme for female scientists realized in international cooperation. As a pilot scheme funded by the 6th Framework Programme of the European Commission, the scientific evaluation was an essential part of the programme, in particular in view of the development of a best practice model for international mentoring. The participants of this programme were female scientists at an early stage of their academic career (postdoc or assistant professor) covering a wide range of science disciplines, including geosciences. This transdisciplinarity as well as the international dimension of the programme have been identified by the participants as one of the keys of success of the programme. In particular, the peer-mentoring across discipline boarders proved to have been an invaluable component of the development programme. This presentation will highlight some of the main findings of the scientific evaluation of the programme and focus on some additional personal insights from the participants.

  10. Maine: Early Head Start Initiatives

    ERIC Educational Resources Information Center

    Center for Law and Social Policy, Inc. (CLASP), 2012

    2012-01-01

    Maine has two initiatives that build on Early Head Start (EHS). The first initiative, Fund for a Healthy Maine, has since 2001 provided tobacco settlement money to existing Head Start and EHS programs to expand the number of children who receive full-day, full-year services. Local programs have the option of using these funds for EHS, depending on…

  11. 75 FR 11837 - Chesapeake Bay Watershed Initiative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... DEPARTMENT OF AGRICULTURE Commodity Credit Corporation Chesapeake Bay Watershed Initiative AGENCY...: Notice of availability of program funds for the Chesapeake Bay Watershed Initiative. SUMMARY: The... through the Chesapeake Bay Watershed Initiative for agricultural producers in the Chesapeake Bay watershed...

  12. Quality of analgesia in physician-operated telemedical prehospital emergency care is comparable to physician-based prehospital care - a retrospective longitudinal study.

    PubMed

    Lenssen, Niklas; Krockauer, Andreas; Beckers, Stefan K; Rossaint, Rolf; Hirsch, Frederik; Brokmann, Jörg C; Bergrath, Sebastian

    2017-05-08

    Acute pain is a common reason for summoning emergency medical services (EMS). Yet in several countries the law restricts opioid-based analgesia administration to physicians. Telemedical support of paramedics is a novel approach to enable timely treatment under the guidance of a physician. In this retrospective observational study, conducted in the EMS of Aachen, Germany, the analgesic quality and occurrence of adverse events were compared between telemedically-supported paramedics (July-December, 2014) and a historical control group (conventional on-scene EMS physicians; January-March, 2014). pain (initial numerical rating scale (NRS) ≥5) and/or performed analgesia. Telemedically-assisted analgesia was performed in 149 patients; conventional analgesia in 199 control cases. Teleconsultation vs. Initial NRS scores were 8.0 ± 1.5 and 8.1 ± 1.7. Complete NRS documentation was carried out in 140/149 vs. 130/199 cases, p < 0.0001. NRS scores were reduced by 4.94 ± 2.01 and 4.84 ± 2.28 (p = 0.5379), leading to mean NRS scores at emergency room arrival of 3.1 ± 1.7 vs. 3.3 ± 1.9 (p = 0.5229). No severe adverse events occurred in either group. Clinically relevant pain reduction was achieved in both groups. Thus, the concept of remote physician-based telemedically-delegated analgesia by paramedics is effective compared to analgesia by on-scene EMS physicians and safe.

  13. Comparing Web-Based Provider-Initiated and Patient-Initiated Survivorship Care Planning for Cancer Patients: A Randomized Controlled Trial

    PubMed Central

    Tolbert, Elliott; Hannum, Susan M; Radhakrishnan, Archana; Zorn, Kelsey; Blackford, Amanda; Greco, Stephen; Smith, Karen; Snyder, Claire F

    2016-01-01

    Background Survivorship care plans (SCPs) are intended to facilitate communication and coordination between patients, oncologists, and primary care providers. Most SCP initiatives have focused on oncology providers initiating the SCP process, but time and resource barriers have limited uptake. Objective This trial compares the feasibility and value of 2 Web-based SCP tools: provider-initiated versus patient-initiated. Methods This mixed-methods study recruited clinicians from 2 academically-affiliated community oncology practices. Eligible patients were treated by a participating oncologist, had nonmetastatic cancer, completed acute treatment ≤ 2 months before enrollment, and had no evidence of disease. Patients were randomized 1:1 to either provider-initiated or patient-initiated SCPs—both are Web-based tools. We conducted qualitative interviews with providers at baseline and follow-up and with patients 2 months after enrollment. In addition, patients were administered the Preparing for Life as a (New) Survivor (PLANS) and Cancer Survivors’ Unmet Needs (CaSUN) surveys at baseline and 2 months. Results A total of 40 providers were approached for the study, of whom 13 (33%) enrolled. Providers or clinic staff required researcher assistance to identify eligible patients; 41 patients were randomized, of whom 25 completed follow-up (61%; 13 provider-initiated, 12 patient-initiated). Of the 25, 11 (44%) had initiated the SCP; 5 (20%) provided the SCP to their primary care provider. On the Preparing for Life as a (New) Survivor and Cancer Survivors’ Unmet Needs, patients in both arms tended to report high knowledge and confidence and few unmet needs. In qualitative interviews, providers and patients discussed SCPs’ value. Conclusions Regardless of patient- versus provider-initiated templates and the Web-based design of these tools, barriers to survivorship care planning persist. Further efforts should emphasize workflow functions for identifying and completing

  14. 40 CFR 63.6610 - By what date must I conduct the initial performance tests or other initial compliance...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... initial performance tests or other initial compliance demonstrations if I own or operate a stationary RICE... performance tests or other initial compliance demonstrations if I own or operate a stationary RICE with a site... stationary RICE with a site rating of more than 500 brake HP located at a major source of HAP emissions you...

  15. 40 CFR 63.6610 - By what date must I conduct the initial performance tests or other initial compliance...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... initial performance tests or other initial compliance demonstrations if I own or operate a stationary RICE... performance tests or other initial compliance demonstrations if I own or operate a stationary RICE with a site... stationary RICE with a site rating of more than 500 brake HP located at a major source of HAP emissions you...

  16. 75 FR 26271 - Fair Housing Initiatives Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-11

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5376-N-33] Fair Housing Initiatives... Department in selecting the highest ranked applicants to receive funds under the Fair Housing Initiatives... following initiatives; Private Enforcement, Education and Outreach, and Fair Housing Organizations. The...

  17. Initiation precursors and initiators in laser-induced copolymerization of styrene and maleic anhydride in acetone

    NASA Technical Reports Server (NTRS)

    Miner, Gilda A.; Meador, Willard E.; Chang, C. Ken

    1990-01-01

    The initiation step of photopolymerized styrene/maleic anhydride copolymer was investigated at 365 nm. UV absorption measurements provide decisive evidence that the styrene/maleic anhydride charge transfer complex is the sole absorbing species; however, key laser experiments suggest intermediate reactions lead to a monoradical initiating species. A mechanism for the photoinitiation step of the copolymer is proposed.

  18. Aerial Refueling Clearance Initiation Request

    DTIC Science & Technology

    2016-07-14

    and receiver agencies. The AR Clearance Initiation Request document recognizes the requirement for definitive aerial refueling agreements between...and contractual tanker support requests from one organization or nation to another. The AR Clearance Initiation Request document is not intended to...proprietary, sensitive, classified or otherwise restricted information. ARSAG documents, as prepared, are not DOD, MOD or NATO standards, but provide

  19. The drift velocity monitoring system of the CMS barrel muon chambers

    NASA Astrophysics Data System (ADS)

    Altenhöfer, Georg; Hebbeker, Thomas; Heidemann, Carsten; Reithler, Hans; Sonnenschein, Lars; Teyssier, Daniel

    2018-04-01

    The drift velocity is a key parameter of drift chambers. Its value depends on several parameters: electric field, pressure, temperature, gas mixture, and contamination, for example, by ambient air. A dedicated Velocity Drift Chamber (VDC) with 1-L volume has been built at the III. Phys. Institute A, RWTH Aachen, in order to monitor the drift velocity of all CMS barrel muon Drift Tube chambers. A system of six VDCs was installed at CMS and has been running since January 2011. We present the VDC monitoring system, its principle of operation, and measurements performed.

  20. Revisiting Shock Initiation Modeling of Homogeneous Explosives

    NASA Astrophysics Data System (ADS)

    Partom, Yehuda

    2013-04-01

    Shock initiation of homogeneous explosives has been a subject of research since the 1960s, with neat and sensitized nitromethane as the main materials for experiments. A shock initiation model of homogeneous explosives was established in the early 1960s. It involves a thermal explosion event at the shock entrance boundary, which develops into a superdetonation that overtakes the initial shock. In recent years, Sheffield and his group, using accurate experimental tools, were able to observe details of buildup of the superdetonation. There are many papers on modeling shock initiation of heterogeneous explosives, but there are only a few papers on modeling shock initiation of homogeneous explosives. In this article, bulk reaction reactive flow equations are used to model homogeneous shock initiation in an attempt to reproduce experimental data of Sheffield and his group. It was possible to reproduce the main features of the shock initiation process, including thermal explosion, superdetonation, input shock overtake, overdriven detonation after overtake, and the beginning of decay toward Chapman-Jouget (CJ) detonation. The time to overtake (TTO) as function of input pressure was also calculated and compared to the experimental TTO.

  1. Surgeon General's Family Health History Initiative

    MedlinePlus

    ... Source Code The Surgeon General's Family Health History Initiative To help focus attention on the importance of ... health campaign, called the Surgeon General's Family History Initiative, to encourage all American families to learn more ...

  2. STI Program Multimedia Initiative

    NASA Technical Reports Server (NTRS)

    Cotter, Gladys A.; Kaye, Karen

    1993-01-01

    This paper relates the experience of the NASA Scientific and Technical Information Program in introducing multimedia within the STI Program framework. A discussion of multimedia technology is included to provide context for the STI Program effort. The STI Program's Multimedia Initiative is discussed in detail. Parallels and differences between multimedia and traditional information systems project development are highlighted. Challenges faced by the program in initiating its multimedia project are summarized along with lessons learned. The paper concludes with a synopsis of the benefits the program hopes to provide its users through the introduction of multimedia illustrated by examples of successful multimedia projects.

  3. Shock initiation of nitromethane

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yoo, C.S.; Holmes, N.C.

    1993-12-31

    The shock initiation processes of nitromethane have been examined by using a fast time-resolved emission spectroscopy at a two-stage gas gun. a broad, but strong emission has been observed in a spectral range between 350 and 700 nm from shocked nitromethane above 9 GPa. The temporal profile suggests that shocked nitromethane detonates through three characteristic periods, namely an induction period, a hock initiation period, and a thermal explosion period. This paper discusses temporal and chemical characteristics of these periods and present the temperature of the shock-detonating nitromethane at pressures between 9 and 15 GPa.

  4. National Nanotechnology Initiative: Driving Innovation & Competitiveness

    DTIC Science & Technology

    2007-09-19

    networking & IT National Nanotechnology Initiative Complex biological systems Environment Next Generation Air Transportation Systems Federal scientific ... collections Science of Science Policy Slide 9: A little history about the National Nanotechnology Initiative: The interagency program was

  5. Motivation and Training Initiation: Evidence from Poland

    ERIC Educational Resources Information Center

    Mielniczuk, Emilia; Laguna, Mariola

    2017-01-01

    Purpose: Based on the self-determination theory and the model of action phases, the present study aims to provide insight into motivational factors that are important for training initiation. It investigates the relations between three types of motivation (intrinsic, extrinsic and amotivation) and training initiation: intention to initiate new…

  6. 46 CFR 110.30-3 - Initial inspection.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Initial inspection. 110.30-3 Section 110.30-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Testing and Inspection § 110.30-3 Initial inspection. The initial inspection, which may be a series of...

  7. 46 CFR 110.30-3 - Initial inspection.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Initial inspection. 110.30-3 Section 110.30-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING GENERAL PROVISIONS Testing and Inspection § 110.30-3 Initial inspection. The initial inspection, which may be a series of...

  8. 10 CFR 110.130 - Initiation of rulemaking.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Initiation of rulemaking. 110.130 Section 110.130 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Rulemaking § 110.130 Initiation of rulemaking. The Commission may initiate action to amend the regulations in this...

  9. 10 CFR 75.32 - Initial inventory report.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Initial inventory report. 75.32 Section 75.32 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) SAFEGUARDS ON NUCLEAR MATERIAL-IMPLEMENTATION OF US/IAEA AGREEMENT Reports § 75.32 Initial inventory report. (a) The initial inventory reporting date shall be the...

  10. 24 CFR 125.301 - Education and Outreach Initiative.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Education and Outreach Initiative... FAIR HOUSING FAIR HOUSING INITIATIVES PROGRAM § 125.301 Education and Outreach Initiative. (a) The Education and Outreach Initiative provides funding for the purpose of developing, implementing, carrying out...

  11. 24 CFR 125.501 - Fair Housing Organizations Initiative.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Initiative. 125.501 Section 125.501 Housing and Urban Development Regulations Relating to Housing and Urban... FAIR HOUSING FAIR HOUSING INITIATIVES PROGRAM § 125.501 Fair Housing Organizations Initiative. (a) The Fair Housing Organizations Initiative of the FHIP provides funding to develop or expand the ability of...

  12. 24 CFR 125.301 - Education and Outreach Initiative.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Education and Outreach Initiative... FAIR HOUSING FAIR HOUSING INITIATIVES PROGRAM § 125.301 Education and Outreach Initiative. (a) The Education and Outreach Initiative provides funding for the purpose of developing, implementing, carrying out...

  13. 24 CFR 125.301 - Education and Outreach Initiative.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Education and Outreach Initiative... FAIR HOUSING FAIR HOUSING INITIATIVES PROGRAM § 125.301 Education and Outreach Initiative. (a) The Education and Outreach Initiative provides funding for the purpose of developing, implementing, carrying out...

  14. 24 CFR 125.301 - Education and Outreach Initiative.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Education and Outreach Initiative... FAIR HOUSING FAIR HOUSING INITIATIVES PROGRAM § 125.301 Education and Outreach Initiative. (a) The Education and Outreach Initiative provides funding for the purpose of developing, implementing, carrying out...

  15. 24 CFR 125.301 - Education and Outreach Initiative.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Education and Outreach Initiative... FAIR HOUSING FAIR HOUSING INITIATIVES PROGRAM § 125.301 Education and Outreach Initiative. (a) The Education and Outreach Initiative provides funding for the purpose of developing, implementing, carrying out...

  16. 19 CFR 10.532 - Integrated Sourcing Initiative.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Integrated Sourcing Initiative. 10.532 Section 10... Trade Agreement Rules of Origin § 10.532 Integrated Sourcing Initiative. (a) For purposes of General... Sourcing Initiative if: (1) The good, in its condition as imported, is both classified in a tariff...

  17. 10 CFR 2.801 - Initiation of rulemaking.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Initiation of rulemaking. 2.801 Section 2.801 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Rulemaking § 2.801 Initiation of rulemaking. Rulemaking may be initiated by the Commission at its own...

  18. Focusing educational initiatives

    NASA Technical Reports Server (NTRS)

    Parks, George K.

    1990-01-01

    The United States will soon be facing a critical shortage of aerospace scientists and engineers. To address this problem, Space Grant Colleges can assist in focusing interest in existing educational initiatives and in creating new educational opportunities, particularly for women and underrepresented minorities.

  19. Initial conditions for critical Higgs inflation

    NASA Astrophysics Data System (ADS)

    Salvio, Alberto

    2018-05-01

    It has been pointed out that a large non-minimal coupling ξ between the Higgs and the Ricci scalar can source higher derivative operators, which may change the predictions of Higgs inflation. A variant, called critical Higgs inflation, employs the near-criticality of the top mass to introduce an inflection point in the potential and lower drastically the value of ξ. We here study whether critical Higgs inflation can occur even if the pre-inflationary initial conditions do not satisfy the slow-roll behavior (retaining translation and rotation symmetries). A positive answer is found: inflation turns out to be an attractor and therefore no fine-tuning of the initial conditions is necessary. A very large initial Higgs time-derivative (as compared to the potential energy density) is compensated by a moderate increase in the initial field value. These conclusions are reached by solving the exact Higgs equation without using the slow-roll approximation. This also allows us to consistently treat the inflection point, where the standard slow-roll approximation breaks down. Here we make use of an approach that is independent of the UV completion of gravity, by taking initial conditions that always involve sub-planckian energies.

  20. Hybrid Black-Hole Binary Initial Data

    NASA Technical Reports Server (NTRS)

    Mundim, Bruno C.; Kelly, Bernard J.; Nakano, Hiroyuki; Zlochower, Yosef; Campanelli, Manuela

    2010-01-01

    "Traditional black-hole binary puncture initial data is conformally flat. This unphysical assumption is coupled with a lack of radiation signature from the binary's past life. As a result, waveforms extracted from evolutions of this data display an abrupt jump. In Kelly et al. [Class. Quantum Grav. 27:114005 (2010)], a new binary black-hole initial data with radiation contents derived in the post-Newtonian (PN) calculations was adapted to puncture evolutions in numerical relativity. This data satisfies the constraint equations to the 2.5PN order, and contains a transverse-traceless "wavy" metric contribution, violating the standard assumption of conformal flatness. Although the evolution contained less spurious radiation, there were undesired features; the unphysical horizon mass loss and the large initial orbital eccentricity. Introducing a hybrid approach to the initial data evaluation, we significantly reduce these undesired features."

  1. Dynamics of an Overdriven Nitromethane Initiation System

    NASA Astrophysics Data System (ADS)

    Hároz, E. H.; Rae, P. J.; Armstrong, C. L.; Baca, E. V.; Campbell, C.; Gunderson, J. A.; Holmes, M.; Lopez-Pulliam, I.; Vaughan, L. D.; Dickson, P. M.

    2017-06-01

    For upcoming large-scale HE experiments, an initiation system is needed to ensure uniform and simultaneous burn. To that end, we developed an initiation system based on nitromethane. Initial, small-scale tests characterized the response of the nitromethane in the proposed cylindrical initiator geometry, indicating robust detonation under a variety of conditions such as a plane wave lenses & cylinders of PBX 9501 into a flyer plate or direct-drive. Detonation velocity, as measured by piezoelectric pin time-of-arrival measurements along the length and at bottom of vessel, shows an overdriven response. All cases show a detonation velocity faster than the literature value of 7.3 km s-1 for nitromethane, with the fastest velocity occurring for the 8-detonator, 8'' cylinder case with a velocity = 7.7 km s-1. Streak camera imaging characterized the curvature of the shock front as it arrived at the bottom of the vessel via spark gap. A final test of the initiator system looked at the expansion of the initiator vessel walls via PDV, showing velocities up to 3.5 km s-1. Finally, our initiator was placed inside a secondary vessel containing 1000 lbs of nitromethane. High-speed photography & pin data indicate complete symmetrical burn of the secondary nitromethane.

  2. 49 CFR 1103.4 - Initial appearances.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Initial appearances. 1103.4 Section 1103.4 Transportation Other Regulations Relating to Transportation (Continued) SURFACE TRANSPORTATION BOARD, DEPARTMENT OF TRANSPORTATION RULES OF PRACTICE PRACTITIONERS General Information § 1103.4 Initial appearances...

  3. Mobile Health Initiatives in Vietnam: Scoping Study

    PubMed Central

    Lam, Jeffrey A; Dang, Linh Thuy; Phan, Ngoc Tran; Trinh, Hue Thi; Vu, Nguyen Cong

    2018-01-01

    Background Mobile health (mHealth) offers a promising solution to the multitude of challenges the Vietnamese health system faces, but there is a scarcity of published information on mHealth in Vietnam. Objective The objectives of this scoping study were (1) to summarize the extent, range, and nature of mHealth initiatives in Vietnam and (2) to examine the opportunities and threats of mHealth utilization in the Vietnamese context. Methods This scoping study systematically identified and extracted relevant information from 20 past and current mHealth initiatives in Vietnam. The study includes multimodal information sources, including published literature, gray literature (ie, government reports and unpublished literature), conference presentations, Web-based documents, and key informant interviews. Results We extracted information from 27 records from the electronic search and conducted 14 key informant interviews, allowing us to identify 20 mHealth initiatives in Vietnam. Most of the initiatives were primarily funded by external donors (n=15), while other initiatives were government funded (n=1) or self-funded (n=4). A majority of the initiatives targeted vulnerable and hard-to-reach populations (n=11), aimed to prevent the occurrence of disease (n=12), and used text messaging (short message service, SMS) as part of their intervention (n=14). The study revealed that Vietnamese mHealth implementation has been challenged by factors including features unique to the Vietnamese language (n=4) and sociocultural factors (n=3). Conclusions The largest threats to the popularity of mHealth initiatives are the absence of government policy, lack of government interest, heavy dependence on foreign funding, and lack of technological infrastructure. Finally, while current mHealth initiatives have already demonstrated promising opportunities for alternative models of funding, such as social entrepreneurship or private business models, sustainable mHealth initiatives outside of

  4. The SEED Initiative

    ERIC Educational Resources Information Center

    Teich, Carolyn R.

    2011-01-01

    Committed to fulfilling the promise of the green economy, the American Association of Community Colleges (AACC) launched the Sustainability Education and Economic Development (SEED) initiative (www.theseedcenter.org) in October 2010. The project advances sustainability and clean energy workforce development practices at community colleges by…

  5. Civil space technology initiative

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The Civil Space Technology Initiative (CSTI) is a major, focused, space technology program of the Office of Aeronautics, Exploration and Technology (OAET) of NASA. The program was initiated to advance technology beyond basic research in order to expand and enhance system and vehicle capabilities for near-term missions. CSTI takes critical technologies to the point at which a user can confidently incorporate the new or expanded capabilities into relatively near-term, high-priority NASA missions. In particular, the CSTI program emphasizes technologies necessary for reliable and efficient access to and operation in Earth orbit as well as for support of scientific missions from Earth orbit.

  6. Does the cerebellum initiate movement?

    PubMed

    Thach, W T

    2014-02-01

    Opinion is divided on what the exact function of the cerebellum is. Experiments are summarized that support the following views: (1) the cerebellum is a combiner of multiple movement factors; (2) it contains anatomically fixed permanent focal representation of individual body parts (muscles and segments) and movement modes (e.g., vestibular driven vs. cognitive driven); (3) it contains flexible changing representations/memory of physical properties of the body parts including muscle strength, segment inertia, joint viscosity, and segmental interaction torques (dynamics); (4) it contains mechanisms for learning and storage of the properties in item no. 3 through trial-and-error practice; (5) it provides for linkage of body parts, motor modes, and motordynamics via the parallel fiber system; (6) it combines and integrates the many factors so as to initiate coordinated movements of the many body parts; (7) it is thus enabled to play the unique role of initiating coordinated movements; and (8) this unique causative role is evidenced by the fact that: (a) electrical stimulation of the cerebellum can initiate compound coordinated movements; (b) in naturally initiated compound movements, cerebellar discharge precedes that in downstream target structures such as motor cerebral cortex; and (c) cerebellar ablation abolishes the natural production of compound movements in the awake alert individuals.

  7. Improving Initial Assessment: Guide to Good Practice

    ERIC Educational Resources Information Center

    Knasel, Eddy; Meed, John; Rossetti, Anna; Read, Hilary

    2006-01-01

    This guide is aimed at anyone in work-based training who is responsible for learners during their first few weeks. Readers will (1) understand the value and purpose of initial assessment in key skills and Skills for Life; (2) become familiar with a range of techniques for the initial assessment; (3) plan an initial assessment system that is…

  8. Synthesis and testing of ZnO nanoparticles for photo-initiation: experimental observation of two different non-migration initiators for bulk polymerization

    NASA Astrophysics Data System (ADS)

    Schmitt, M.

    2015-05-01

    The migration and transport of polymerization initiators are problematic for commercially used polymerization procedures. For example, UV printing of packaging generates products with potentially harmful components that come in contact with food. Enlarging the size of the initiator is the only way to prevent contamination, e.g., by gas phase transport. In this manuscript, the synthesis and advanced and full analyses of novel nanoparticle-based types of non-migration, fragmenting and non-fragmenting photo-initiators will be presented in detail. This study introduces non-fragmenting/``Norrish type II'' and fragmenting/``Norrish type I'' ZnO nanoparticle-based initiators and compares them with two commercial products, a ``Norrish type I'' initiator and a ``Norrish type II'' initiator. Therefore, inter alia, the recently developed analysis involves examining the solidification by UV-vis and the double bond content by Raman. Irradiation is performed using absolute and spectrally calibrated xenon flash lights. A novel procedure for absolute and spectral calibration of such light sources is also presented. The non-optimized ``Norrish type II'' particle-based initiator is already many times faster than benzophenone, which is a molecular initiator of the same non-fragmenting type. This experimentally observed difference in reactive particle-based systems without co-initiators is unexpected. Co-initiators are normally an additional molecular species, which leads to migration problems. The discovery of significant initiation potential resulting in a very well-dispersed organic-inorganic hybrid material suggests a new field of research opportunities at the interface of physical chemistry, polymer chemistry and engineering science, with enormous value for human health.The migration and transport of polymerization initiators are problematic for commercially used polymerization procedures. For example, UV printing of packaging generates products with potentially harmful

  9. 47 CFR 27.11 - Initial authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Initial authorization. 27.11 Section 27.11 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES MISCELLANEOUS WIRELESS COMMUNICATIONS SERVICES Applications and Licenses § 27.11 Initial authorization. (a) An applicant must file a...

  10. Multimedia Instruction Initiative: Building Faculty Competence.

    ERIC Educational Resources Information Center

    Haile, Penelope J.

    Hofstra University began a university-wide initiative to enhance classroom instruction with multimedia technology and foster collaborative approaches to learning. The Multimedia Instruction Initiative emphasized teamwork among faculty, students, and computer center support staff to develop a technology-enriched learning environment supported by…

  11. 47 CFR 24.11 - Initial authorization.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 2 2011-10-01 2011-10-01 false Initial authorization. 24.11 Section 24.11 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES PERSONAL COMMUNICATIONS... applicant must file a single application for an initial authorization for all markets won and frequency...

  12. Mobile computing initiatives within pharmacy education.

    PubMed

    Cain, Jeff; Bird, Eleanora R; Jones, Mikael

    2008-08-15

    To identify mobile computing initiatives within pharmacy education, including how devices are obtained, supported, and utilized within the curriculum. An 18-item questionnaire was developed and delivered to academic affairs deans (or closest equivalent) of 98 colleges and schools of pharmacy. Fifty-four colleges and schools completed the questionnaire for a 55% completion rate. Thirteen of those schools have implemented mobile computing requirements for students. Twenty schools reported they were likely to formally consider implementing a mobile computing initiative within 5 years. Numerous models of mobile computing initiatives exist in terms of device obtainment, technical support, infrastructure, and utilization within the curriculum. Responders identified flexibility in teaching and learning as the most positive aspect of the initiatives and computer-aided distraction as the most negative, Numerous factors should be taken into consideration when deciding if and how a mobile computing requirement should be implemented.

  13. Precision flyer initiator

    DOEpatents

    Frank, Alan M.; Lee, Ronald S.

    1998-01-01

    A precision flyer initiator forms a substantially spherical detonation wave in a high explosive (HE) pellet. An explosive driver, such as a detonating cord, a wire bridge circuit or a small explosive, is detonated. A flyer material is sandwiched between the explosive driver and an end of a barrel that contains an inner channel. A projectile or "flyer" is sheared from the flyer material by the force of the explosive driver and projected through the inner channel. The flyer than strikes the HE pellet, which is supported above a second end of the barrel by a spacer ring. A gap or shock decoupling material delays the shock wave in the barrel from predetonating the HE pellet before the flyer. A spherical detonation wave is formed in the HE pellet. Thus, a shock wave traveling through the barrel fails to reach the HE pellet before the flyer strikes the HE pellet. The precision flyer initiator can be used in mining devices, well-drilling devices and anti-tank devices.

  14. Precursor processes of human self-initiated action.

    PubMed

    Khalighinejad, Nima; Schurger, Aaron; Desantis, Andrea; Zmigrod, Leor; Haggard, Patrick

    2018-01-15

    A gradual buildup of electrical potential over motor areas precedes self-initiated movements. Recently, such "readiness potentials" (RPs) were attributed to stochastic fluctuations in neural activity. We developed a new experimental paradigm that operationalized self-initiated actions as endogenous 'skip' responses while waiting for target stimuli in a perceptual decision task. We compared these to a block of trials where participants could not choose when to skip, but were instead instructed to skip. Frequency and timing of motor action were therefore balanced across blocks, so that conditions differed only in how the timing of skip decisions was generated. We reasoned that across-trial variability of EEG could carry as much information about the source of skip decisions as the mean RP. EEG variability decreased more markedly prior to self-initiated compared to externally-triggered skip actions. This convergence suggests a consistent preparatory process prior to self-initiated action. A leaky stochastic accumulator model could reproduce this convergence given the additional assumption of a systematic decrease in input noise prior to self-initiated actions. Our results may provide a novel neurophysiological perspective on the topical debate regarding whether self-initiated actions arise from a deterministic neurocognitive process, or from neural stochasticity. We suggest that the key precursor of self-initiated action may manifest as a reduction in neural noise. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  15. Synthesis and testing of ZnO nanoparticles for photo-initiation: experimental observation of two different non-migration initiators for bulk polymerization.

    PubMed

    Schmitt, M

    2015-06-07

    The migration and transport of polymerization initiators are problematic for commercially used polymerization procedures. For example, UV printing of packaging generates products with potentially harmful components that come in contact with food. Enlarging the size of the initiator is the only way to prevent contamination, e.g., by gas phase transport. In this manuscript, the synthesis and advanced and full analyses of novel nanoparticle-based types of non-migration, fragmenting and non-fragmenting photo-initiators will be presented in detail. This study introduces non-fragmenting/"Norrish type II" and fragmenting/"Norrish type I" ZnO nanoparticle-based initiators and compares them with two commercial products, a "Norrish type I" initiator and a "Norrish type II" initiator. Therefore, inter alia, the recently developed analysis involves examining the solidification by UV-vis and the double bond content by Raman. Irradiation is performed using absolute and spectrally calibrated xenon flash lights. A novel procedure for absolute and spectral calibration of such light sources is also presented. The non-optimized "Norrish type II" particle-based initiator is already many times faster than benzophenone, which is a molecular initiator of the same non-fragmenting type. This experimentally observed difference in reactive particle-based systems without co-initiators is unexpected. Co-initiators are normally an additional molecular species, which leads to migration problems. The discovery of significant initiation potential resulting in a very well-dispersed organic-inorganic hybrid material suggests a new field of research opportunities at the interface of physical chemistry, polymer chemistry and engineering science, with enormous value for human health.

  16. Self-Regulation, Metacognition and Child- and Adult-Initiated Activity: Does It Matter Who Initiates the Task?

    ERIC Educational Resources Information Center

    Robson, Sue

    2016-01-01

    Debate about the balance between child- and adult-initiated activities in early childhood settings is long standing. This article reports a study of 29 children aged 4-5 years in a London state school, on the influences of child- and adult-initiated activities on children's self-regulation and metacognition. Whilst both contexts were supportive,…

  17. 40 CFR 610.12 - Program initiative.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 30 2011-07-01 2011-07-01 false Program initiative. 610.12 Section 610.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY RETROFIT DEVICES Test Procedures and Evaluation Criteria General Provisions § 610.12 Program initiative. A...

  18. 40 CFR 610.12 - Program initiative.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 31 2012-07-01 2012-07-01 false Program initiative. 610.12 Section 610.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY RETROFIT DEVICES Test Procedures and Evaluation Criteria General Provisions § 610.12 Program initiative. A...

  19. 40 CFR 610.12 - Program initiative.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 31 2013-07-01 2013-07-01 false Program initiative. 610.12 Section 610.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY RETROFIT DEVICES Test Procedures and Evaluation Criteria General Provisions § 610.12 Program initiative. A...

  20. 40 CFR 610.12 - Program initiative.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 30 2014-07-01 2014-07-01 false Program initiative. 610.12 Section 610.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY RETROFIT DEVICES Test Procedures and Evaluation Criteria General Provisions § 610.12 Program initiative. A...

  1. 75 FR 28778 - Broadband Initiatives Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-24

    ... DEPARTMENT OF AGRICULTURE Rural Utilities Service RIN 0572-ZA01 Broadband Initiatives Program AGENCY: Rural Utilities Service, Department of Agriculture. ACTION: Notice of Extension of filing Public... Initiatives Program (BIP), published in the Federal Register at 75 FR 3820 (January 22, 2010). Such technical...

  2. 50 CFR 296.9 - Initial determination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Initial determination. 296.9 Section 296.9 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE CONTINENTAL SHELF FISHERMEN'S CONTINGENCY FUND § 296.9 Initial determination. The...

  3. Beating the limits with initial correlations

    NASA Astrophysics Data System (ADS)

    Basilewitsch, Daniel; Schmidt, Rebecca; Sugny, Dominique; Maniscalco, Sabrina; Koch, Christiane P.

    2017-11-01

    Fast and reliable reset of a qubit is a key prerequisite for any quantum technology. For real world open quantum systems undergoing non-Markovian dynamics, reset implies not only purification, but in particular erasure of initial correlations between qubit and environment. Here, we derive optimal reset protocols using a combination of geometric and numerical control theory. For factorizing initial states, we find a lower limit for the entropy reduction of the qubit as well as a speed limit. The time-optimal solution is determined by the maximum coupling strength. Initial correlations, remarkably, allow for faster reset and smaller errors. Entanglement is not necessary.

  4. SCB initiator

    DOEpatents

    Bickes Jr., Robert W.; Renlund, Anita M.; Stanton, Philip L.

    1994-11-01

    A detonator for high explosives initiated by mechanical impact includes a cylindrical barrel, a layer of flyer material mechanically covering the barrel at one end, and a semiconductor bridge ignitor including a pair of electrically conductive pads connected by a semiconductor bridge. The bridge is in operational contact with the layer, whereby ignition of said bridge forces a portion of the layer through the barrel to detonate the explosive. Input means are provided for igniting the semiconductor bridge ignitor.

  5. SCB initiator

    DOEpatents

    Bickes, Jr., Robert W.; Renlund, Anita M.; Stanton, Philip L.

    1994-01-01

    A detonator for high explosives initiated by mechanical impact includes a cylindrical barrel, a layer of flyer material mechanically covering the barrel at one end, and a semiconductor bridge ignitor including a pair of electrically conductive pads connected by a semiconductor bridge. The bridge is in operational contact with the layer, whereby ignition of said bridge forces a portion of the layer through the barrel to detonate the explosive. Input means are provided for igniting the semiconductor bridge ignitor.

  6. NASA's Climate Data Services Initiative

    NASA Astrophysics Data System (ADS)

    McInerney, M.; Duffy, D.; Schnase, J. L.; Webster, W. P.

    2013-12-01

    Our understanding of the Earth's processes is based on a combination of observational data records and mathematical models. The size of NASA's space-based observational data sets is growing dramatically as new missions come online. However a potentially bigger data challenge is posed by the work of climate scientists, whose models are regularly producing data sets of hundreds of terabytes or more. It is important to understand that the 'Big Data' challenge of climate science cannot be solved with a single technological approach or an ad hoc assemblage of technologies. It will require a multi-faceted, well-integrated suite of capabilities that include cloud computing, large-scale compute-storage systems, high-performance analytics, scalable data management, and advanced deployment mechanisms in addition to the existing, well-established array of mature information technologies. It will also require a coherent organizational effort that is able to focus on the specific and sometimes unique requirements of climate science. Given that it is the knowledge that is gained from data that is of ultimate benefit to society, data publication and data analytics will play a particularly important role. In an effort to accelerate scientific discovery and innovation through broader use of climate data, NASA Goddard Space Flight Center's Office of Computational and Information Sciences and Technology has embarked on a determined effort to build a comprehensive, integrated data publication and analysis capability for climate science. The Climate Data Services (CDS) Initiative integrates people, expertise, and technology into a highly-focused, next-generation, one-stop climate science information service. The CDS Initiative is providing the organizational framework, processes, and protocols needed to deploy existing information technologies quickly using a combination of enterprise-level services and an expanding array of cloud services. Crucial to its effectiveness, the CDS

  7. Iterative initial condition reconstruction

    NASA Astrophysics Data System (ADS)

    Schmittfull, Marcel; Baldauf, Tobias; Zaldarriaga, Matias

    2017-07-01

    Motivated by recent developments in perturbative calculations of the nonlinear evolution of large-scale structure, we present an iterative algorithm to reconstruct the initial conditions in a given volume starting from the dark matter distribution in real space. In our algorithm, objects are first moved back iteratively along estimated potential gradients, with a progressively reduced smoothing scale, until a nearly uniform catalog is obtained. The linear initial density is then estimated as the divergence of the cumulative displacement, with an optional second-order correction. This algorithm should undo nonlinear effects up to one-loop order, including the higher-order infrared resummation piece. We test the method using dark matter simulations in real space. At redshift z =0 , we find that after eight iterations the reconstructed density is more than 95% correlated with the initial density at k ≤0.35 h Mpc-1 . The reconstruction also reduces the power in the difference between reconstructed and initial fields by more than 2 orders of magnitude at k ≤0.2 h Mpc-1 , and it extends the range of scales where the full broadband shape of the power spectrum matches linear theory by a factor of 2-3. As a specific application, we consider measurements of the baryonic acoustic oscillation (BAO) scale that can be improved by reducing the degradation effects of large-scale flows. In our idealized dark matter simulations, the method improves the BAO signal-to-noise ratio by a factor of 2.7 at z =0 and by a factor of 2.5 at z =0.6 , improving standard BAO reconstruction by 70% at z =0 and 30% at z =0.6 , and matching the optimal BAO signal and signal-to-noise ratio of the linear density in the same volume. For BAO, the iterative nature of the reconstruction is the most important aspect.

  8. Department-Initiated Change

    ERIC Educational Resources Information Center

    Watson, Anne; De Geest, Els

    2014-01-01

    This paper reports the activity of three secondary school mathematics departments in England in self-initiated states of change that led to overall improvements in students' achievements when compared to previous cohorts. This took place without intervention and without their participation in external projects. They provide examples of departments…

  9. 45 CFR 672.20 - Initial decision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 3 2010-10-01 2010-10-01 false Initial decision. 672.20 Section 672.20 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENFORCEMENT AND... reply briefs, if any, has expired. The initial decision shall contain findings of fact, conclusions...

  10. 45 CFR 672.20 - Initial decision.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 3 2011-10-01 2011-10-01 false Initial decision. 672.20 Section 672.20 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENFORCEMENT AND... reply briefs, if any, has expired. The initial decision shall contain findings of fact, conclusions...

  11. 45 CFR 672.20 - Initial decision.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 3 2014-10-01 2014-10-01 false Initial decision. 672.20 Section 672.20 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENFORCEMENT AND... reply briefs, if any, has expired. The initial decision shall contain findings of fact, conclusions...

  12. 45 CFR 672.20 - Initial decision.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 3 2012-10-01 2012-10-01 false Initial decision. 672.20 Section 672.20 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENFORCEMENT AND... reply briefs, if any, has expired. The initial decision shall contain findings of fact, conclusions...

  13. 45 CFR 672.20 - Initial decision.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 3 2013-10-01 2013-10-01 false Initial decision. 672.20 Section 672.20 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION ENFORCEMENT AND... reply briefs, if any, has expired. The initial decision shall contain findings of fact, conclusions...

  14. Community College Environmental Scanning Initiative, 2004

    ERIC Educational Resources Information Center

    Association of Community College Trustees, 2004

    2004-01-01

    The Association of Community College Trustees' (ACCT's) Member Communications Committee commissioned SunGard Collegis to conduct an environmental scanning initiative to identify the top social, political and other environmental challenges which are, or will be affecting colleges and communities in the near future. The initiative included a…

  15. [Panorama of self-management initiatives in Spain].

    PubMed

    Nuño-Solinis, Roberto; Rodríguez-Pereira, Carolina; Piñera-Elorriaga, Koldo; Zaballa-González, Irune; Bikandi-Irazabal, Javier

    2013-01-01

    To describe the current situation of self-management initiatives in Spain. We performed a descriptive study of self-management support initiatives in Spain from the perspective of the patient as expert. Three databases were searched in October 2010 (Pubmed, Scientific Electronic Library Online [SCIELO] and Indice Médico Español [IME]), using the following Keywords «paciente experto» (expert patient), «paciente activo» (active patient) and «apoyo al autocuidado» (self-management support). Web sites were also consulted, using the same key words. Of the initiatives found, we selected those with the most advanced development and continuity, using the perspective of the expert patient (in which patients have an active role) and with a systematic format and methodology. A questionnaire was designed and was sent to the heads of the selected initiatives in the last quarter of 2010. To update the information, the questionnaire was sent again between August and September, 2012. Subsequently, the web sites were visited to review their contents and presence in social networks. Seven initiatives were identified in the autonomous regions of Murcia, Andalusia, Galicia, Castile-La Mancha, Basque Country, and Catalonia. These initiatives used distinct methodologies, formats and assessment systems. In Spain, there is increasing interest in the development of self-management support programs, although their scope is limited and their impact is mostly unknown, except for patient satisfaction. There is a need for studies on results assessment to identify the impact of these initiatives in our setting, as well as for studies on their implementation to encourage the introduction of patient activation initiatives in routine clinical practice. Copyright © 2012 SESPAS. Published by Elsevier Espana. All rights reserved.

  16. Control of Initialized Fractional-Order Systems

    NASA Technical Reports Server (NTRS)

    Hartly, Tom T.; Lorenzo, Carl F.

    2002-01-01

    Due to the importance of historical effects in fractional-order systems, this paper presents a general fractional-order control theory that includes the time-varying initialization response. Previous studies have not properly accounted for these historical effects. The initialization response, along with the forced response, for fractional-order systems is determined. Stability properties of fractional-order systems are presented in the complex Airplane, which is a transformation of the s-plane. Time responses are discussed with respect to pole positions in the complex Airplane and frequency response behavior is included. A fractional-order vector space representation, which is a generalization of the state space concept, is presented including the initialization response. Control methods for vector representations of initialized fractional-order systems are shown. Nyquist, root-locus, and other input-output control methods are adapted to the control of fractional-order systems. Finally, the fractional-order differintegral is generalized to continuous order-distributions that have the possibility of including a continuum of fractional orders in a system element.

  17. Shock initiation of nitromethane

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yoo, C.S.; Holmes, N.C.

    1994-07-10

    The shock initiation processes of nitromethane have been examined by using a fast time-resolved emission spectroscopy at a two-stage gas gun. A broad, but strong emission has been observed in a spectral range between 350 nm and 700 nm from the shocked nitromethane above 9 GPa. The temporal profile suggests that the shocked nitromethane detonates through three characteristic periods, namely an induction period, a shock initiation period, and a thermal explosion period. In this paper we will discuss the temporal and chemical characteristics of these periods and present the temperature of the shock-detonating nitromethane at pressures between 9 and 15more » GPa. [copyright]American Institute of Physics« less

  18. 76 FR 35715 - Establishment of the SelectUSA Initiative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-20

    ... Establishment of the SelectUSA Initiative By the authority vested in me as President by the Constitution and the... unnecessary obstacles to investment. Sec. 2. SelectUSA Initiative. (a) Establishment. There is established the SelectUSA Initiative (Initiative), a Government-wide initiative to attract and retain investment in the...

  19. Open science initiatives: challenges for public health promotion.

    PubMed

    Holzmeyer, Cheryl

    2018-03-07

    While academic open access, open data and open science initiatives have proliferated in recent years, facilitating new research resources for health promotion, open initiatives are not one-size-fits-all. Health research particularly illustrates how open initiatives may serve various interests and ends. Open initiatives not only foster new pathways of research access; they also discipline research in new ways, especially when associated with new regimes of research use and peer review, while participating in innovation ecosystems that often perpetuate existing systemic biases toward commercial biomedicine. Currently, many open initiatives are more oriented toward biomedical research paradigms than paradigms associated with public health promotion, such as social determinants of health research. Moreover, open initiatives too often dovetail with, rather than challenge, neoliberal policy paradigms. Such initiatives are unlikely to transform existing health research landscapes and redress health inequities. In this context, attunement to social determinants of health research and community-based local knowledge is vital to orient open initiatives toward public health promotion and health equity. Such an approach calls for discourses, norms and innovation ecosystems that contest neoliberal policy frameworks and foster upstream interventions to promote health, beyond biomedical paradigms. This analysis highlights challenges and possibilities for leveraging open initiatives on behalf of a wider range of health research stakeholders, while emphasizing public health promotion, health equity and social justice as benchmarks of transformation.

  20. Research Ethics Considerations Regarding the Cancer Moonshot Initiative.

    PubMed

    Hammer, Marilyn J

    2016-07-01

    If the Precision Medicine Initiative was the launching pad, the Cancer Moonshot Initiative is the liftoff. A billion-dollar mission to "eliminate cancer as we know it," the Cancer Moonshot Initiative underscores the Precision Medicine Initiative's near-term focus in oncology research and translation. Spearheaded by Vice President Biden, the goal is to condense a decade of research into actionable results within five years.

  1. Mobile Health Initiatives in Vietnam: Scoping Study.

    PubMed

    Lam, Jeffrey A; Dang, Linh Thuy; Phan, Ngoc Tran; Trinh, Hue Thi; Vu, Nguyen Cong; Nguyen, Cuong Kieu

    2018-04-24

    Mobile health (mHealth) offers a promising solution to the multitude of challenges the Vietnamese health system faces, but there is a scarcity of published information on mHealth in Vietnam. The objectives of this scoping study were (1) to summarize the extent, range, and nature of mHealth initiatives in Vietnam and (2) to examine the opportunities and threats of mHealth utilization in the Vietnamese context. This scoping study systematically identified and extracted relevant information from 20 past and current mHealth initiatives in Vietnam. The study includes multimodal information sources, including published literature, gray literature (ie, government reports and unpublished literature), conference presentations, Web-based documents, and key informant interviews. We extracted information from 27 records from the electronic search and conducted 14 key informant interviews, allowing us to identify 20 mHealth initiatives in Vietnam. Most of the initiatives were primarily funded by external donors (n=15), while other initiatives were government funded (n=1) or self-funded (n=4). A majority of the initiatives targeted vulnerable and hard-to-reach populations (n=11), aimed to prevent the occurrence of disease (n=12), and used text messaging (short message service, SMS) as part of their intervention (n=14). The study revealed that Vietnamese mHealth implementation has been challenged by factors including features unique to the Vietnamese language (n=4) and sociocultural factors (n=3). The largest threats to the popularity of mHealth initiatives are the absence of government policy, lack of government interest, heavy dependence on foreign funding, and lack of technological infrastructure. Finally, while current mHealth initiatives have already demonstrated promising opportunities for alternative models of funding, such as social entrepreneurship or private business models, sustainable mHealth initiatives outside of those funded by external donors have not yet been

  2. Professional Development Initiative. Proposal for Action

    ERIC Educational Resources Information Center

    Center for Child and Family Policy, Duke University (NJ1), 2004

    2004-01-01

    With the support of the Education Cabinet, the Z. Smith Reynolds Foundation launched the Professional Development Initiative in early 2004. The Initiative's Implementation Work Group focused on four key areas to enhance North Carolina's system of professional development for K-12 teachers. Those areas were: (1) Professional Development Online…

  3. 10 CFR 26.55 - Initial authorization.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Initial authorization. 26.55 Section 26.55 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.55 Initial authorization. (a) Before granting authorization to an individual who has never held authorization under this...

  4. 10 CFR 26.55 - Initial authorization.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Initial authorization. 26.55 Section 26.55 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.55 Initial authorization. (a) Before granting authorization to an individual who has never held authorization under this...

  5. Sustainability Factors for E-Learning Initiatives

    ERIC Educational Resources Information Center

    Gunn, Cathy

    2010-01-01

    This paper examines the challenges that "grass roots" e-learning initiatives face in trying to become sustainable. A cross-institutional study focused on local, rather than centrally driven, initiatives. A number of successful e-learning innovations were identified that had been driven by capable teachers seeking solutions to real…

  6. 10 CFR 26.55 - Initial authorization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Initial authorization. 26.55 Section 26.55 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.55 Initial authorization. (a) Before granting authorization to an individual who has never held authorization under this...

  7. 10 CFR 26.55 - Initial authorization.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Initial authorization. 26.55 Section 26.55 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.55 Initial authorization. (a) Before granting authorization to an individual who has never held authorization under this...

  8. 10 CFR 26.55 - Initial authorization.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Initial authorization. 26.55 Section 26.55 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Granting and Maintaining Authorization § 26.55 Initial authorization. (a) Before granting authorization to an individual who has never held authorization under this...

  9. College and Career Counseling Training Initiative

    ERIC Educational Resources Information Center

    Southern Regional Education Board (SREB), 2014

    2014-01-01

    The Southern Regional Education Board's (SREB) College and Career Counseling Training Initiative works to increase the knowledge and skills of counselors who advise students on their postsecondary aspirations. Membership in the initiative provides access to Strategies in College and Career Counseling, a series of online training modules that can…

  10. Transformative Change Initiative

    ERIC Educational Resources Information Center

    Bragg, D. D.; Kirby, C.; Witt, M. A.; Richie, D.; Mix, S.; Feldbaum, M.; Liu, S.; Mason, M.

    2014-01-01

    The Transformative Change Initiative (TCI) is dedicated to assisting community colleges to scale up innovation in the form of guided pathways, programs of study, and evidence-based strategies to improve student outcomes and program, organization, and system performance. The impetus for TCI is the Trade Adjustment Assistance Community College and…

  11. Administering an epoch initiated for remote memory access

    DOEpatents

    Blocksome, Michael A; Miller, Douglas R

    2014-03-18

    Methods, systems, and products are disclosed for administering an epoch initiated for remote memory access that include: initiating, by an origin application messaging module on an origin compute node, one or more data transfers to a target compute node for the epoch; initiating, by the origin application messaging module after initiating the data transfers, a closing stage for the epoch, including rejecting any new data transfers after initiating the closing stage for the epoch; determining, by the origin application messaging module, whether the data transfers have completed; and closing, by the origin application messaging module, the epoch if the data transfers have completed.

  12. Cyclopropenimine superbases: Competitive initiation processes in lactide polymerization

    DOE PAGES

    Stukenbroeker, Tyler S.; Bandar, Jeffrey S.; Zhang, Xiangyi; ...

    2015-07-30

    Cyclopropenimine superbases were employed in this study to catalyze the ring-opening polymerization of lactide. Polymerization occurred readily in the presence and absence of alcohol initiators. Polymerizations in the absence of alcohol initiators revealed a competitive initiation mechanism involving deprotonation of lactide by the cyclopropenimine to generate an enolate. NMR and MALDI-TOF analysis of the poly(lactides) generated from cyclopropenimines in the absence of alcohol initiators showed acylated lactide and hydroxyl end groups. Finally, model studies and comparative experiments with guanidine and phosphazene catalysts revealed the subtle influence of the nature of the superbase on competitive initiation processes.

  13. Administering an epoch initiated for remote memory access

    DOEpatents

    Blocksome, Michael A; Miller, Douglas R

    2012-10-23

    Methods, systems, and products are disclosed for administering an epoch initiated for remote memory access that include: initiating, by an origin application messaging module on an origin compute node, one or more data transfers to a target compute node for the epoch; initiating, by the origin application messaging module after initiating the data transfers, a closing stage for the epoch, including rejecting any new data transfers after initiating the closing stage for the epoch; determining, by the origin application messaging module, whether the data transfers have completed; and closing, by the origin application messaging module, the epoch if the data transfers have completed.

  14. Administering an epoch initiated for remote memory access

    DOEpatents

    Blocksome, Michael A.; Miller, Douglas R.

    2013-01-01

    Methods, systems, and products are disclosed for administering an epoch initiated for remote memory access that include: initiating, by an origin application messaging module on an origin compute node, one or more data transfers to a target compute node for the epoch; initiating, by the origin application messaging module after initiating the data transfers, a closing stage for the epoch, including rejecting any new data transfers after initiating the closing stage for the epoch; determining, by the origin application messaging module, whether the data transfers have completed; and closing, by the origin application messaging module, the epoch if the data transfers have completed.

  15. A mechanical energy analysis of gait initiation

    NASA Technical Reports Server (NTRS)

    Miller, C. A.; Verstraete, M. C.

    1999-01-01

    The analysis of gait initiation (the transient state between standing and walking) is an important diagnostic tool to study pathologic gait and to evaluate prosthetic devices. While past studies have quantified mechanical energy of the body during steady-state gait, to date no one has computed the mechanical energy of the body during gait initiation. In this study, gait initiation in seven normal male subjects was studied using a mechanical energy analysis to compute total body energy. The data showed three separate states: quiet standing, gait initiation, and steady-state gait. During gait initiation, the trends in the energy data for the individual segments were similar to those seen during steady-state gait (and in Winter DA, Quanbury AO, Reimer GD. Analysis of instantaneous energy of normal gait. J Biochem 1976;9:253-257), but diminished in amplitude. However, these amplitudes increased to those seen in steady-state during the gait initiation event (GIE), with the greatest increase occurring in the second step due to the push-off of the foundation leg. The baseline level of mechanical energy was due to the potential energy of the individual segments, while the cyclic nature of the data was indicative of the kinetic energy of the particular leg in swing phase during that step. The data presented showed differences in energy trends during gait initiation from those of steady state, thereby demonstrating the importance of this event in the study of locomotion.

  16. Cancer initiatives in developing countries.

    PubMed

    Mellstedt, H

    2006-06-01

    The coming decades will bring dramatic increases in morbidity and mortality from cancer in the developing world. The burden of cancer is increasing globally, with an expected 20 million new cases per year in 2020, half of which will be in low- and middle-income countries. Despite an already overwhelming burden of health problems, developing countries must somehow address this cancer pandemic and their alarming share of cancer illness. Many large-scale and innovative worldwide initiatives have been launched in the fight against cancer. These programs represent colossal efforts to expand resources for health education among people and healthcare workers in developing countries and to increase awareness of cancer prevention. Many novel evidence-based and culturally-relevant programs are being implemented for screening and early prevention of common cancers. Several key initiatives are supporting clinical research, guideline development, oncology training, and appropriate technology transfer, such as access to electronic medical literature. Treatment programs are expanding access and quality of radiologic and pharmacologic therapies for cancer. These initiatives represent an unprecedented level of and cooperation among international agencies, governmental and nongovernmental organizations, international foundations, scientific societies, local institutions, and industry. This review examines the scope of need in response to the increasing burden of cancer in the developing world and major initiatives that have been created to respond to these needs.

  17. Cost effectiveness of the Oregon quitline "free patch initiative".

    PubMed

    Fellows, Jeffrey L; Bush, Terry; McAfee, Tim; Dickerson, John

    2007-12-01

    We estimated the cost effectiveness of the Oregon tobacco quitline's "free patch initiative" compared to the pre-initiative programme. Using quitline utilisation and cost data from the state, intervention providers and patients, we estimated annual programme use and costs for media promotions and intervention services. We also estimated annual quitline registration calls and the number of quitters and life years saved for the pre-initiative and free patch initiative programmes. Service utilisation and 30-day abstinence at six months were obtained from 959 quitline callers. We compared the cost effectiveness of the free patch initiative (media and intervention costs) to the pre-initiative service offered to insured and uninsured callers. We conducted sensitivity analyses on key programme costs and outcomes by estimating a best case and worst case scenario for each intervention strategy. Compared to the pre-intervention programme, the free patch initiative doubled registered calls, increased quitting fourfold and reduced total costs per quit by $2688. We estimated annual paid media costs were $215 per registered tobacco user for the pre-initiative programme and less than $4 per caller during the free patch initiative. Compared to the pre-initiative programme, incremental quitline promotion and intervention costs for the free patch initiative were $86 (range $22-$353) per life year saved. Compared to the pre-initiative programme, the free patch initiative was a highly cost effective strategy for increasing quitting in the population.

  18. Patient-initiated online support groups: motives for initiation, extent of success and success factors.

    PubMed

    van Uden-Kraan, Cornelia F; Drossaert, Constance H C; Taal, Erik; Seydel, Erwin R; van de Laar, Mart A F J

    2010-01-01

    We studied the success and success factors of online support groups (OSGs) for patients, and the motives and goals of people who start such groups. We interviewed 23 webmasters of OSGs for patients with breast cancer, fibromyalgia and arthritis. The majority were women (n = 20) and most were patients (n = 21). Analysis of the interviews revealed that webmasters had altruistic and intrinsic motives for initiating an online support group. They defined success as the fulfilment of the goals they had in mind when they initiated their groups. To be able to make a group successful, decisions about its organization and management need to be coherent with these goals. Most webmasters stressed that promoting the group, keeping it alive and moderating the messages were vital success factors during the evolution stage. Management of the OSGs took up much of the webmasters' time and energy. On average webmasters were occupied with the group for 10-15 hours a week. Our study provides an overview of the pros and cons of differing decisions that have to be made when initiating an OSG.

  19. Charging conditions research to increase the initial projected velocity at different initial charge temperatures

    NASA Astrophysics Data System (ADS)

    Ishchenko, Aleksandr; Burkin, Viktor; Kasimov, Vladimir; Samorokova, Nina; Zykova, Angelica; Diachkovskii, Alexei

    2017-11-01

    The problems of the defense industry occupy the most important place in the constantly developing modern world. The daily development of defense technology does not stop, nor do studies on internal ballistics. The scientists of the whole world are faced with the task of managing the main characteristics of a ballistic experiment. The main characteristics of the ballistic experiment are the maximum pressure in the combustion chamber Pmax and the projected velocity at the time of barrel leaving UM. During the work the combustion law of the new high-energy fuel was determined in a ballistic experiment for different initial temperatures. This combustion law was used for a parametric study of depending Pmax and UM from a powder charge mass and a traveling charge was carried out. The optimal conditions for loading were obtained for improving the initial velocity at pressures up to 600 MPa for different initial temperatures. In this paper, one of the most promising schemes of throwing is considered, as well as a method for increasing the muzzle velocity of a projected element to 3317 m/s.

  20. AtaT blocks translation initiation by N-acetylation of the initiator tRNAfMet.

    PubMed

    Jurėnas, Dukas; Chatterjee, Sneha; Konijnenberg, Albert; Sobott, Frank; Droogmans, Louis; Garcia-Pino, Abel; Van Melderen, Laurence

    2017-06-01

    Toxin-antitoxin (TA) loci are prevalent in bacterial genomes. They are suggested to play a central role in dormancy and persister states. Under normal growth conditions, TA toxins are neutralized by their cognate antitoxins, and under stress conditions, toxins are freed and inhibit essential cellular processes using a variety of mechanisms. Here we characterize ataR-ataT, a novel TA system, from enterohemorrhagic Escherichia coli. We show that the toxin AtaT is a GNAT family enzyme that transfers an acetyl group from acetyl coenzyme A to the amine group of the methionyl aminoacyl moiety of initiator tRNA. AtaT specifically modifies Met-tRNA fMet , but no other aminoacyl-tRNAs, including the elongator Met-tRNA Met . We demonstrate that once acetylated, AcMet-tRNA fMet fails to interact with initiation factor-2 (IF2), resulting in disruption of the translation initiation complex. This work reveals a new mechanism of translation inhibition and confirms Met-tRNA fMet as a prime target to efficiently block cell growth.

  1. Children's Alcohol Initiation: An Analytic Overview

    ERIC Educational Resources Information Center

    Ward, Bernadette; Snow, Pamela; Aroni, Rosalie

    2010-01-01

    Many parents support the "supervised introduction" of alcohol to children. While initiation to regular alcohol consumption in early adolescence has been linked with alcohol-related problems in adult life, the findings from these studies cannot be extrapolated to early childhood. The definition of initiation to alcohol in early childhood is often…

  2. 10 CFR 824.13 - Initial decision.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Initial decision. 824.13 Section 824.13 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... other matters as justice may require. (b) The Hearing Officer shall serve all parties with the initial...

  3. 10 CFR 824.13 - Initial decision.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Initial decision. 824.13 Section 824.13 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... other matters as justice may require. (b) The Hearing Officer shall serve all parties with the initial...

  4. 10 CFR 824.13 - Initial decision.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Initial decision. 824.13 Section 824.13 Energy DEPARTMENT OF ENERGY PROCEDURAL RULES FOR THE ASSESSMENT OF CIVIL PENALTIES FOR CLASSIFIED INFORMATION SECURITY... other matters as justice may require. (b) The Hearing Officer shall serve all parties with the initial...

  5. 40 CFR 227.29 - Initial mixing.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) Initial mixing is defined to be that dispersion or diffusion of liquid, suspended particulate, and solid... adequate to predict initial dispersion and diffusion of the waste, these shall be used, if necessary, in.... (2) When field data on the dispersion and diffusion of a waste of characteristics similar to that...

  6. 40 CFR 227.29 - Initial mixing.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...) Initial mixing is defined to be that dispersion or diffusion of liquid, suspended particulate, and solid... adequate to predict initial dispersion and diffusion of the waste, these shall be used, if necessary, in.... (2) When field data on the dispersion and diffusion of a waste of characteristics similar to that...

  7. 40 CFR 227.29 - Initial mixing.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) Initial mixing is defined to be that dispersion or diffusion of liquid, suspended particulate, and solid... adequate to predict initial dispersion and diffusion of the waste, these shall be used, if necessary, in.... (2) When field data on the dispersion and diffusion of a waste of characteristics similar to that...

  8. 40 CFR 227.29 - Initial mixing.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) Initial mixing is defined to be that dispersion or diffusion of liquid, suspended particulate, and solid... adequate to predict initial dispersion and diffusion of the waste, these shall be used, if necessary, in.... (2) When field data on the dispersion and diffusion of a waste of characteristics similar to that...

  9. 12 CFR 404.8 - Initial determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Initial determination. 404.8 Section 404.8 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES INFORMATION DISCLOSURE Procedures for Disclosure of Records Under the Freedom of Information Act. § 404.8 Initial determination. (a) Authority to...

  10. 7 CFR 1786.159 - Initial closing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 12 2010-01-01 2010-01-01 false Initial closing. 1786.159 Section 1786.159... Discounted Prepayments on RUS Electric Loans § 1786.159 Initial closing. (a) Upon receipt of the prepayment agreement, the borrower may submit, pursuant to the terms of the prepayment agreement, a closing request...

  11. Health Care Provider Initiative Strategic Plan

    ERIC Educational Resources Information Center

    National Environmental Education & Training Foundation, 2012

    2012-01-01

    This document lays out the strategy for achieving the goals and objectives of NEETF's "Health Care Provider Initiative." The goal of NEETF's "Health Care Provider Initiative" is to incorporate environmental health into health professionals' education and practice in order to improve health care and public health, with a special emphasis on…

  12. Physical initialization using SSM/I rain rates

    NASA Technical Reports Server (NTRS)

    Krishnamurti, T. N.; Bedi, H. S.; Ingles, Kevin

    1993-01-01

    Following our recent study on physical initialization for tropical prediction using rain rates based on outgoing long-wave radiation, the present study demonstrates a major improvement from the use of microwave radiance-based rain rates. A rain rate algorithm is used on the data from a special sensor microwave instrument (SSM/I). The initialization, as before, uses a reverse surface similarity theory, a reverse cumulus parameterization algorithm, and a bisection method to minimize the difference between satellite-based and the model-based outgoing long-wave radiation. These are invoked within a preforecast Newtonian relaxation phase of the initialization. These tests are carried out with a high-resolution global spectral model. The impact of the initialization on forecast is tested for a complex triple typhoon scenario over the Western Pacific Ocean during September 1987. A major impact from the inclusion of the SSM/I is demonstrated. Also addressed are the spin-up issues related to the typhoon structure and the improved water budget from the physical initialization.

  13. Initiator system in holographic photopolymer materials

    NASA Astrophysics Data System (ADS)

    Ortuño, M.; Fernández, E.; Fuentes, R.; Gallego, S.; Márquez, A.

    2010-05-01

    The photopolymers with a hydrophilic matrix as poly(vinyl alcohol), PVA, are versatile holographic recording materials in hologram recording experiments. They use water as solvent and they can be made in layers with several thickness. One of the photopolymers more used is composed of acrylamide as polymerizable monomer, PVA and water as binder. The pair: triethanolamine, TEA, and the dye yellowish eosin, YE, is widely used as initiator system due to its high sensitivity and efficiency. TEA is the radical initiator more used with dyes derived from fluorescein as YE because they can generate a radical by redox reaction under dye excitation by light. The dye is bleached in this process because is decomposed in the photoinitiation reaction. The ethylenediaminetetraacetic acid EDTA has a molecular structure very similar to TEA and therefore could replace it in this kind of photopolymers. The 4,4' azo-bis-(4-cyanopentanoic acid), ACPA, is a radical initiator that is soluble in water and usually used in polymerizations in solution with thermal initiation. In this work, we use EDTA and ACPA in order to check their properties as radical initiator in the photochemical reaction that takes place inside the photopolymer while a hologram is being recorded. We will compare the results obtained with those derived from TEA and will evaluate the possibilities for these substances.

  14. Practical recommendations for the evaluation of improvement initiatives

    PubMed Central

    Parry, Gareth; Coly, Astou; Goldmann, Don; Rowe, Alexander K; Chattu, Vijay; Logiudice, Deneil; Rabrenovic, Mihajlo; Nambiar, Bejoy

    2018-01-01

    Abstract A lack of clear guidance for funders, evaluators and improvers on what to include in evaluation proposals can lead to evaluation designs that do not answer the questions stakeholders want to know. These evaluation designs may not match the iterative nature of improvement and may be imposed onto an initiative in a way that is impractical from the perspective of improvers and the communities with whom they work. Consequently, the results of evaluations are often controversial, and attribution remains poorly understood. Improvement initiatives are iterative, adaptive and context-specific. Evaluation approaches and designs must align with these features, specifically in their ability to consider complexity, to evolve as the initiative adapts over time and to understand the interaction with local context. Improvement initiatives often identify broadly defined change concepts and provide tools for care teams to tailor these in more detail to local conditions. Correspondingly, recommendations for evaluation are best provided as broad guidance, to be tailored to the specifics of the initiative. In this paper, we provide practical guidance and recommendations that funders and evaluators can use when developing an evaluation plan for improvement initiatives that seeks to: identify the questions stakeholders want to address; develop the initial program theory of the initiative; identify high-priority areas to measure progress over time; describe the context the initiative will be applied within; and identify experimental or observational designs that will address attribution. PMID:29447410

  15. Quantum Measurement and Initial Conditions

    NASA Astrophysics Data System (ADS)

    Stoica, Ovidiu Cristinel

    2016-03-01

    Quantum measurement finds the observed system in a collapsed state, rather than in the state predicted by the Schrödinger equation. Yet there is a relatively spread opinion that the wavefunction collapse can be explained by unitary evolution (for instance in the decoherence approach, if we take into account the environment). In this article it is proven a mathematical result which severely restricts the initial conditions for which measurements have definite outcomes, if pure unitary evolution is assumed. This no-go theorem remains true even if we take the environment into account. The result does not forbid a unitary description of the measurement process, it only shows that such a description is possible only for very restricted initial conditions. The existence of such restrictions of the initial conditions can be understood in the four-dimensional block universe perspective, as a requirement of global self-consistency of the solutions of the Schrödinger equation.

  16. 39 CFR 963.18 - Initial decision.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Initial decision. 963.18 Section 963.18 Postal Service UNITED STATES POSTAL SERVICE PROCEDURES RULES OF PRACTICE IN PROCEEDINGS RELATIVE TO VIOLATIONS OF THE PANDERING ADVERTISEMENTS STATUTE, 39 U.S.C. 3008 § 963.18 Initial decision. Unless given orally at...

  17. 12 CFR 404.15 - Initial determination.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Initial determination. 404.15 Section 404.15 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES INFORMATION DISCLOSURE Access to Records Under the Privacy Act of 1974 § 404.15 Initial determination. (a) Time for processing. The Freedom of...

  18. 49 CFR 1503.655 - Initial decision.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Rules of Practice in TSA Civil Penalty Actions § 1503.655 Initial decision. (a) Contents. The ALJ may... copies of that initial decision available to all parties and the TSA decision maker. (b) Written decision... ALJ is persuasive authority in any other civil penalty action, unless appealed and reversed by the TSA...

  19. Implementing a University-Wide Change Initiative

    ERIC Educational Resources Information Center

    Styron, Ronald A., Jr.; Michaelsen, Larry K.; Styron, Jennifer L.

    2015-01-01

    This paper provides an account of the pilot and first year of a university improvement initiative, developed in response to a reaffirmation mandate from the Southern Association of Colleges and Schools Commission on Colleges. The initiative focused on increasing student retention and enhancing learning through the campus-wide use of team-based…

  20. Managing Dualities in Planned Change Initiatives

    ERIC Educational Resources Information Center

    Barge, J. Kevin; Lee, Michael; Maddux, Kristy; Nabring, Richard; Townsend, Bryan

    2008-01-01

    Dualities play an important role in creating the conditions for change and managing planned change initiatives. Building on Seo, Putnam, and Bartunek's (2003) work, this study focuses on the dualities associated with managing change processes. A case study of a planned change process called the Circle of Prosperity Initiative, a multi-stakeholder…

  1. Evaluating the Legacy of Community Health Initiatives. A Conceptual Framework and Example from the California Wellness Foundation's Health Improvement Initiative

    ERIC Educational Resources Information Center

    Beery, William L.; Senter, Sandra; Cheadle, Allen; Greenwald, Howard P.; Pearson, David; Brousseau, Ruth; Nelson, Gary D.

    2005-01-01

    Community health initiatives typically involve time-limited funding from foundation or government grants to support their initial activities. But if there are to be lasting improvements in health outcomes, initiative activities must be sustained over a relatively long period of time. Despite the importance of sustaining work begun under health…

  2. Gravity wave initiated convection

    NASA Astrophysics Data System (ADS)

    Hung, R. J.

    1990-09-01

    The vertical velocity of convection initiated by gravity waves was investigated. In one particular case, the convective motion-initiated and supported by the gravity wave-induced activity (excluding contributions made by other mechanisms) reached its maximum value about one hour before the production of the funnel clouds. In another case, both rawinsonde and geosynchronous satellite imagery were used to study the life cycles of severe convective storms. Cloud modelling with input sounding data and rapid-scan imagery from GOES were used to investigate storm cloud formation, development and dissipation in terms of growth and collapse of cloud tops, as well as, the life cycles of the penetration of overshooting turrets above the tropopause. The results based on these two approaches are presented and discussed.

  3. Hypervelocity Impact Initiation of Explosive Transfer Lines

    NASA Technical Reports Server (NTRS)

    Bjorkman, Michael D.; Christiansen, Eric L.

    2012-01-01

    The Gemini, Apollo and Space Shuttle spacecraft utilized explosive transfer lines (ETL) in a number of applications. In each case the ETL was located behind substantial structure and the risk of impact initiation by micrometeoroids and orbital debris was negligible. A current NASA program is considering an ETL to synchronize the actuation of pyrobolts to release 12 capture latches in a contingency. The space constraints require placing the ETL 50 mm below the 1 mm thick 2024-T72 Whipple shield. The proximity of the ETL to the thin shield prompted analysts at NASA to perform a scoping analysis with a finite-difference hydrocode to calculate impact parameters that would initiate the ETL. The results suggest testing is required and a 12 shot test program with surplused Shuttle ETL is scheduled for February 2012 at the NASA White Sands Test Facility. Explosive initiation models are essential to the analysis and one exists in the CTH library for HNS I, but not the HNS II used in the Shuttle 2.5 gr/ft rigid shielded mild detonating cord (SMDC). HNS II is less sensitive than HNS I so it is anticipated that these results using the HNS I model are conservative. Until the hypervelocity impact test results are available, the only check on the analysis was comparison with the Shuttle qualification test result that a 22 long bullet would not initiate the SMDC. This result was reproduced by the hydrocode simulation. Simulations of the direct impact of a 7 km/s aluminum ball, impacting at 0 degree angle of incidence, onto the SMDC resulted in a 1.5 mm diameter ball initiating the SMDC and 1.0 mm ball failing to initiate it. Where one 1.0 mm ball could not initiate the SMDC, a cluster of six 1.0 mm diameter aluminum balls striking simultaneously could. Thus the impact parameters that will result in initiating SMDC located behind a Whipple shield will depend on how well the shield fragments the projectile and spreads the fragments. An end-to-end simulation of the impact of an

  4. 48 CFR 25.405 - Caribbean Basin Trade Initiative.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Initiative. 25.405 Section 25.405 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS FOREIGN ACQUISITION Trade Agreements 25.405 Caribbean Basin Trade Initiative. Under the Caribbean Basin Trade Initiative, the United States Trade Representative has determined that, for...

  5. Mixed-Initiative Clustering

    ERIC Educational Resources Information Center

    Huang, Yifen

    2010-01-01

    Mixed-initiative clustering is a task where a user and a machine work collaboratively to analyze a large set of documents. We hypothesize that a user and a machine can both learn better clustering models through enriched communication and interactive learning from each other. The first contribution or this thesis is providing a framework of…

  6. 16 CFR 3.51 - Initial decision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Initial decision. 3.51 Section 3.51 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE RULES OF PRACTICE FOR ADJUDICATIVE PROCEEDINGS Decision § 3.51 Initial decision. (a) When filed and when effective. The Administrative Law Judge shall file an...

  7. Turnaround Arts Initiative: Final Evaluatiion Report

    ERIC Educational Resources Information Center

    Stoelinga, Sara Ray; Silk, Yael; Reddy, Prateek; Rahman, Nadiv

    2015-01-01

    The President's Committee on the Arts and the Humanities (PCAH) released the results of an independent study that shows substantial gains in student achievement at schools participating in its Turnaround Arts initiative. The eight schools' in the pilot phase of the initiative, showing increases in reading and math scores, as well as an increase in…

  8. 10 CFR 13.37 - Initial decision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Initial decision. 13.37 Section 13.37 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.37 Initial decision. (a) The ALJ shall issue an... any portions thereof, violate § 13.3; and (2) If the person is liable for penalties or assessments...

  9. Precision flyer initiator

    DOEpatents

    Frank, A.M.; Lee, R.S.

    1998-05-26

    A precision flyer initiator forms a substantially spherical detonation wave in a high explosive (HE) pellet. An explosive driver, such as a detonating cord, a wire bridge circuit or a small explosive, is detonated. A flyer material is sandwiched between the explosive driver and an end of a barrel that contains an inner channel. A projectile or ``flyer`` is sheared from the flyer material by the force of the explosive driver and projected through the inner channel. The flyer than strikes the HE pellet, which is supported above a second end of the barrel by a spacer ring. A gap or shock decoupling material delays the shock wave in the barrel from predetonating the HE pellet before the flyer. A spherical detonation wave is formed in the HE pellet. Thus, a shock wave traveling through the barrel fails to reach the HE pellet before the flyer strikes the HE pellet. The precision flyer initiator can be used in mining devices, well-drilling devices and anti-tank devices. 10 figs.

  10. Structural Basis of Mitochondrial Transcription Initiation.

    PubMed

    Hillen, Hauke S; Morozov, Yaroslav I; Sarfallah, Azadeh; Temiakov, Dmitry; Cramer, Patrick

    2017-11-16

    Transcription in human mitochondria is driven by a single-subunit, factor-dependent RNA polymerase (mtRNAP). Despite its critical role in both expression and replication of the mitochondrial genome, transcription initiation by mtRNAP remains poorly understood. Here, we report crystal structures of human mitochondrial transcription initiation complexes assembled on both light and heavy strand promoters. The structures reveal how transcription factors TFAM and TFB2M assist mtRNAP to achieve promoter-dependent initiation. TFAM tethers the N-terminal region of mtRNAP to recruit the polymerase to the promoter whereas TFB2M induces structural changes in mtRNAP to enable promoter opening and trapping of the DNA non-template strand. Structural comparisons demonstrate that the initiation mechanism in mitochondria is distinct from that in the well-studied nuclear, bacterial, or bacteriophage transcription systems but that similarities are found on the topological and conceptual level. These results provide a framework for studying the regulation of gene expression and DNA replication in mitochondria. Copyright © 2017 Elsevier Inc. All rights reserved.

  11. Action Potentials Initiate in the Axon Initial Segment and Propagate Through Axon Collaterals Reliably in Cerebellar Purkinje Neurons

    PubMed Central

    Foust, Amanda; Popovic, Marko; Zecevic, Dejan; McCormick, David A.

    2010-01-01

    Purkinje neurons are the output cells of the cerebellar cortex and generate spikes in two distinct modes, known as simple and complex spikes. Revealing the point of origin of these action potentials, and how they conduct into local axon collaterals, is important for understanding local and distal neuronal processing and communication. By utilizing a recent improvement in voltage sensitive dye imaging technique that provided exceptional spatial and temporal resolution, we were able to resolve the region of spike initiation as well as follow spike propagation into axon collaterals for each action potential initiated on single trials. All fast action potentials, for both simple and complex spikes, whether occurring spontaneously or in response to a somatic current pulse or synaptic input, initiated in the axon initial segment. At discharge frequencies of less than approximately 250 Hz, spikes propagated faithfully through the axon and axon collaterals, in a saltatory manner. Propagation failures were only observed for very high frequencies or for the spikelets associated with complex spikes. These results demonstrate that the axon initial segment is a critical decision point in Purkinje cell processing and that the properties of axon branch points are adjusted to maintain faithful transmission. PMID:20484631

  12. Aquarius: The Instrument and Initial Results

    NASA Technical Reports Server (NTRS)

    Vine, David M Le; Lagerloef, G.S.E.; Ruf, C.; Wentz, F.; Yueh, S.; Piepmeier, J.; Lindstrom, E.; Dinnat, E.

    2012-01-01

    Aquarius was launched on June 10, 2011 aboard the Aquarius/SAC-D observatory and the instrument has been operating continuously since the initial turned-on was completed on August 25. The initial observed antenna temperatures were close to predicted and the first salinity map was released in September. In order to map the ocean salinity field, Aquarius includes several special features such as the inclusion of a scatterometer to provide a roughness correction, measurement of the third Stokes parameter to correct for Faraday rotation, and fast sampling to mitigate the effects of RFI. This paper provides an overview of the instrument and an example of initial results. Details are covered in subsequent papers in the session on Aquarius

  13. Topology-optimized metasurfaces: impact of initial geometric layout.

    PubMed

    Yang, Jianji; Fan, Jonathan A

    2017-08-15

    Topology optimization is a powerful iterative inverse design technique in metasurface engineering and can transform an initial layout into a high-performance device. With this method, devices are optimized within a local design phase space, making the identification of suitable initial geometries essential. In this Letter, we examine the impact of initial geometric layout on the performance of large-angle (75 deg) topology-optimized metagrating deflectors. We find that when conventional metasurface designs based on dielectric nanoposts are used as initial layouts for topology optimization, the final devices have efficiencies around 65%. In contrast, when random initial layouts are used, the final devices have ultra-high efficiencies that can reach 94%. Our numerical experiments suggest that device topologies based on conventional metasurface designs may not be suitable to produce ultra-high-efficiency, large-angle metasurfaces. Rather, initial geometric layouts with non-trivial topologies and shapes are required.

  14. Let Us Use LET: A Quality Improvement Initiative.

    PubMed

    Sherman, Joshua M; Sheppard, Patrick; Hoppa, Eric; Krief, William; Avarello, Jahn

    2016-07-01

    Well-managed pain is associated with faster recovery, fewer complications, and decreased use of resources. In children, pain relief is also associated with higher patient and parent satisfaction. Studies have shown that there are deficiencies in pediatric pain management. LET gel (lidocaine 4%, epinephrine 0.1%, and tetracaine 0.5%) is a topical anesthetic that is routinely used before laceration repair. The aim of this study was to determine if educational initiatives as part of a quality improvement initiative lead to increased rates of early topical anesthetic usage in a large urban pediatric emergency department. The initiative consisted of an educational session and a triage booth poster. We then reviewed the charts of patients with facial and scalp lacerations for the month before the initiative, the month after the initiative, and 1 year after the initiative. We assessed if LET gel usage and time to administration improved and were sustainable. We reviewed 138 charts. Before the initiative, only 57.4% received LET gel before facial laceration repair with a mean time to application of 58.3 minutes. One month after the initiative, there was an increase in LET gel application by 20.1% with a reduction in time to application by 35.9 minutes (P < 0.05). In addition, these improvements were significantly sustainable. One year after the interventions, 82.4% received LET before facial laceration repair, and the time to LET application was 27.8 minutes. Simple educational initiatives can improve the use of topical anesthetics. By using educational tools as part of a quality improvement initiative, we were able to significantly improve the rates of LET gel application for facial lacerations in children and decrease the time to administration.

  15. About the RAS Initiative

    Cancer.gov

    The RAS Initiative, a "hub and spoke" model, connects researchers to better understand and target the more than 30% of cancers driven by mutations in RAS genes. Includes oversight and contact information.

  16. Climatic triggers for peatland initiation

    NASA Astrophysics Data System (ADS)

    Morris, Paul J.; Swindles, Graeme T.; Valdes, Paul J.; Ivanovic, Ruza F.; Gregoire, Lauren J.; Smith, Mark W.; Tarasov, Lev; Haywood, Alan M.; Bacon, Karen L.

    2017-04-01

    Peatlands are carbon-dense wetlands characterised by waterlogged, organic-rich soils. Modern-day peatlands have formed mainly since the Last Glacial Maximum (LGM), and despite covering only 3 % of the Earth's land surface are thought to store more than a third of all global soil carbon in the form of poorly decomposed plant detritus. Concern exists that this globally important carbon store may be vulnerable to near-future warming and changes in precipitation patterns, although the links between peatland development and climate are contested. The climatic and other environmental conditions that facilitate the initiation of peat are particularly poorly understood. We present the results of a novel, global study into the climate space of peat initiation since the LGM. We compiled a catalogue of radiocarbon dates of peat initiation from 942 sites that span a range of latitudes and biomes. We used the locations and ages of these peatlands to interrogate downscaled climate hindcasts at 500-yr intervals from a coupled atmosphere-ocean-vegetation general circulation model, HadCM3. This powerful combination of modelling and observational data provides a globally-consistent, temporally-extensive estimate of the climate spaces of peat initiation. In particular, it allows us to identify local and regional climatic changes that may have acted as triggers for peat formation. Peatlands in mid- and high-latitudes of both hemispheres, particularly in maritime locations, developed shortly after local increases in the time integral of growing season temperatures, and were seemingly not influenced by rainfall regime. Peat initiation at such sites appears to have been stimulated by temperature-driven increases in plant productivity in cold, postglacial landscapes, and was not water limited. The exception is the large peatland complex of the Western Siberian Lowlands, which was not glaciated during the last glacial period, and which appears to have been prompted instead by a strong

  17. CMS tier structure and operation of the experiment-specific tasks in Germany

    NASA Astrophysics Data System (ADS)

    Nowack, A.

    2008-07-01

    In Germany, several university institutes and research centres take part in the CMS experiment. Concerning the data analysis, a couple of computing centres at different Tier levels, ranging from Tier 1 to Tier 3, exists at these places. The German Tier 1 centre GridKa at the research centre at Karlsruhe serves all four LHC experiments as well as four non-LHC experiments. With respect to the CMS experiment, GridKa is mainly involved in central tasks. The Tier 2 centre in Germany consists of two sites, one at the research centre DESY at Hamburg and one at RWTH Aachen University, forming a federated Tier 2 centre. Both parts cover different aspects of a Tier 2 centre. The German Tier 3 centres are located at the research centre DESY at Hamburg, at RWTH Aachen University, and at the University of Karlsruhe. Furthermore the building of a German user analysis facility is planned. Since the CMS community in German is rather small, a good cooperation between the different sites is essential. This cooperation includes physical topics as well as technical and operational issues. All available communication channels such as email, phone, monthly video conferences, and regular personal meetings are used. For example, the distribution of data sets is coordinated globally within Germany. Also the CMS-specific services such as the data transfer tool PhEDEx or the Monte Carlo production are operated by people from different sites in order to spread the knowledge widely and increase the redundancy in terms of operators.

  18. eMedOffice: a web-based collaborative serious game for teaching optimal design of a medical practice.

    PubMed

    Hannig, Andreas; Kuth, Nicole; Özman, Monika; Jonas, Stephan; Spreckelsen, Cord

    2012-10-31

    Preparing medical students for the takeover or the start-up of a medical practice is an important challenge in Germany today. Therefore, this paper presents a computer-aided serious game (eMedOffice) developed and currently in use at the RWTH Aachen University Medical School. The game is part of the attempt to teach medical students the organizational and conceptual basics of the medical practice of a general practitioner in a problem-based learning environment. This paper introduces methods and concepts used to develop the serious game and describes the results of an evaluation of the game's application in curricular courses at the Medical School. Results of the conducted evaluation gave evidence of a positive learning effect of the serious game. Educational supervisors observed strong collaboration among the players inspired by the competitive gaming aspects. In addition, an increase in willingness to learn and the exploration of new self-invented ideas were observed and valuable proposals for further prospective enhancements were elicited. A statistical analysis of the results of an evaluation provided a clear indication of the positive learning effect of the game. A usability questionnaire survey revealed a very good overall score of 4.07 (5=best, 1=worst). We consider web-based, collaborative serious games to be a promising means of improving medical education. The insights gained by the implementation of eMedOffice will promote the future development of more effective serious games for integration into curricular courses of the RWTH Aachen University Medical School.

  19. eMedOffice: A web-based collaborative serious game for teaching optimal design of a medical practice

    PubMed Central

    2012-01-01

    Background Preparing medical students for the takeover or the start-up of a medical practice is an important challenge in Germany today. Therefore, this paper presents a computer-aided serious game (eMedOffice) developed and currently in use at the RWTH Aachen University Medical School. The game is part of the attempt to teach medical students the organizational and conceptual basics of the medical practice of a general practitioner in a problem-based learning environment. This paper introduces methods and concepts used to develop the serious game and describes the results of an evaluation of the game's application in curricular courses at the Medical School. Results Results of the conducted evaluation gave evidence of a positive learning effect of the serious game. Educational supervisors observed strong collaboration among the players inspired by the competitive gaming aspects. In addition, an increase in willingness to learn and the exploration of new self-invented ideas were observed and valuable proposals for further prospective enhancements were elicited. A statistical analysis of the results of an evaluation provided a clear indication of the positive learning effect of the game. A usability questionnaire survey revealed a very good overall score of 4.07 (5=best, 1=worst). Conclusions We consider web-based, collaborative serious games to be a promising means of improving medical education. The insights gained by the implementation of eMedOffice will promote the future development of more effective serious games for integration into curricular courses of the RWTH Aachen University Medical School. PMID:23110606

  20. Correlates of sexual initiation among European adolescents.

    PubMed

    Gambadauro, Pietro; Carli, Vladimir; Hadlaczky, Gergö; Sarchiapone, Marco; Apter, Alan; Balazs, Judit; Banzer, Raphaela; Bobes, Julio; Brunner, Romuald; Cosman, Doina; Farkas, Luca; Haring, Christian; Hoven, Christina W; Kaess, Michael; Kahn, Jean Pierre; McMahon, Elaine; Postuvan, Vita; Sisask, Merike; Värnik, Airi; Zadravec Sedivy, Nusa; Wasserman, Danuta

    2018-01-01

    Sexuality is a physiological component of adolescent development, though early initiation is associated with reproductive health risk. This study aimed at identifying correlates and predictors of sexual initiation in a large multinational cohort of European adolescents. A questionnaire addressing socio-demographics, behaviours, mental health and sexual activity, was delivered to 11,110 adolescents recruited from 168 randomly selected schools in 10 European countries between 2009 and 2011. A follow-up questionnaire was delivered after 12 months. The longitudinal association of baseline risk behaviors, psychological attributes and contextual vulnerabilities, with sexual initiation during follow-up was evaluated through simple and multivariable age/sex stratified logistic regression. Multinomial logistic regression measured the association between predictors and sexual initiation with or without coexisting reproductive risk factors, such as multiple partners or infrequent condom use. Baseline sexual experience was reported by 19.2% of 10,757 respondents (median age 15; IQR 14-15; females 59.6%). This was significantly more frequent among pupils older than 15 (41%) and males (20.8%). Of 7,111 pupils without previous experience who were available at follow-up (response rate 81.8%), 17% reported sexual initiation, without differences between females and males. Baseline smoking (age/sex adjusted odds ratio [aOR] 3.63), alcohol use (aOR 2.95), illegal drugs use (aOR 2.72), and poor sleep (aOR 1.71) predicted sexual initiation. Stratified analyses showed a particularly strong association in case of younger and female pupils, and, among girls, when initiation was reported together with multiple partners and/or infrequent condom use. Externalizing (i.e. conduct and hyperactivity) symptoms independently predicted sexual initiation. Internalizing difficulties (i.e. emotional and peer problems) were negatively associated with early and risky sexual initiation among boys

  1. Contributions of the Akamai Workforce Initiative

    ERIC Educational Resources Information Center

    St. John, Mark; Castori, Pam

    2014-01-01

    This brief presents a third party, external perspective on the Akamai Workforce Initiative (AWI), highlighting some of the contributions of the initiative over the last ten years. AWI is a program that seeks to develop a skilled local STEM workforce to meet the needs of Hawai'i's growing high-tech industry. It began as an internship program…

  2. Framework for Evaluation of Equity Initiatives

    ERIC Educational Resources Information Center

    Bexley, Emmaline; Harris, Kerri-Lee; James, Richard

    2010-01-01

    The Framework for Evaluation of Equity Initiatives has been prepared to support the Go8 Equity Strategy. Its purpose is to assist Group of Eight (Go8) universities to evaluate the effectiveness of their equity initiatives and interventions in the context of federal policies and the distinctive missions and responsibilities of the individual Go8…

  3. Initial Teaching Orthographies.

    ERIC Educational Resources Information Center

    Dewey, Godfrey

    To achieve its purpose, an initial teaching orthography (i.t.o.) should be as simple in form and substance as possible; it should be phonemic rather than phonetic. The 40 sounds distinguished by Pitmanic shorthand and some provision for schwa can serve as a basic code. The symbols can be derived from either of two major sources--standardizing the…

  4. 39 CFR 3020.11 - Initial Mail Classification Schedule.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Initial Mail Classification Schedule. 3020.11 Section 3020.11 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL PRODUCT LISTS Mail Classification Schedule § 3020.11 Initial Mail Classification Schedule. The initial Mail Classification Schedule shall...

  5. 75 FR 77935 - Patriot Express Pilot Loan Initiative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-14

    ... SMALL BUSINESS ADMINISTRATION Patriot Express Pilot Loan Initiative AGENCY: U.S. Small Business Administration (SBA). ACTION: Notice of extension of the Patriot Express Pilot Loan Initiative. SUMMARY: This notice extends the Patriot Express Pilot Loan Initiative in its current form through December 31, 2013...

  6. Different types of pausing modes during transcription initiation.

    PubMed

    Lerner, Eitan; Ingargiola, Antonino; Lee, Jookyung J; Borukhov, Sergei; Michalet, Xavier; Weiss, Shimon

    2017-08-08

    In many cases, initiation is rate limiting to transcription. This due in part to the multiple cycles of abortive transcription that delay promoter escape and the transition from initiation to elongation. Pausing of transcription in initiation can further delay promoter escape. The previously hypothesized pausing in initiation was confirmed by two recent studies from Duchi et al. 1 and from Lerner, Chung et al. 2 In both studies, pausing is attributed to a lack of forward translocation of the nascent transcript during initiation. However, the two works report on different pausing mechanisms. Duchi et al. report on pausing that occurs during initiation predominantly on-pathway of transcript synthesis. Lerner, Chung et al. report on pausing during initiation as a result of RNAP backtracking, which is off-pathway to transcript synthesis. Here, we discuss these studies, together with additional experimental results from single-molecule FRET focusing on a specific distance within the transcription bubble. We show that the results of these studies are complementary to each other and are consistent with a model involving two types of pauses in initiation: a short-lived pause that occurs in the translocation of a 6-mer nascent transcript and a long-lived pause that occurs as a result of 1-2 nucleotide backtracking of a 7-mer transcript.

  7. Linking mechanistic and behavioral responses to sublethal esfenvalerate exposure in the endangered delta smelt; Hypomesus transpacificus (Fam. Osmeridae)

    PubMed Central

    2009-01-01

    Background The delta smelt (Hypomesus transpacificus) is a pelagic fish species listed as endangered under both the USA Federal and Californian State Endangered Species Acts and considered an indicator of ecosystem health in its habitat range, which is limited to the Sacramento-San Joaquin estuary in California, USA. Anthropogenic contaminants are one of multiple stressors affecting this system, and among them, current-use insecticides are of major concern. Interrogative tools are required to successfully monitor effects of contaminants on the delta smelt, and to research potential causes of population decline in this species. We have created a microarray to investigate genome-wide effects of potentially causative stressors, and applied this tool to assess effects of the pyrethroid insecticide esfenvalerate on larval delta smelt. Selected genes were further investigated as molecular biomarkers using quantitative PCR analyses. Results Exposure to esfenvalerate affected swimming behavior of larval delta smelt at concentrations as low as 0.0625 μg.L-1, and significant differences in expression were measured in genes involved in neuromuscular activity. Alterations in the expression of genes associated with immune responses, along with apoptosis, redox, osmotic stress, detoxification, and growth and development appear to have been invoked by esfenvalerate exposure. Swimming impairment correlated significantly with expression of aspartoacylase (ASPA), an enzyme involved in brain cell function and associated with numerous human diseases. Selected genes were investigated for their use as molecular biomarkers, and strong links were determined between measured downregulation in ASPA and observed behavioral responses in fish exposed to environmentally relevant pyrethroid concentrations. Conclusions The results of this study show that microarray technology is a useful approach in screening for, and generation of molecular biomarkers in endangered, non-model organisms

  8. A Polar Initial Alignment Algorithm for Unmanned Underwater Vehicles

    PubMed Central

    Yan, Zheping; Wang, Lu; Wang, Tongda; Zhang, Honghan; Zhang, Xun; Liu, Xiangling

    2017-01-01

    Due to its highly autonomy, the strapdown inertial navigation system (SINS) is widely used in unmanned underwater vehicles (UUV) navigation. Initial alignment is crucial because the initial alignment results will be used as the initial SINS value, which might affect the subsequent SINS results. Due to the rapid convergence of Earth meridians, there is a calculation overflow in conventional initial alignment algorithms, making conventional initial algorithms are invalid for polar UUV navigation. To overcome these problems, a polar initial alignment algorithm for UUV is proposed in this paper, which consists of coarse and fine alignment algorithms. Based on the principle of the conical slow drift of gravity, the coarse alignment algorithm is derived under the grid frame. By choosing the velocity and attitude as the measurement, the fine alignment with the Kalman filter (KF) is derived under the grid frame. Simulation and experiment are realized among polar, conventional and transversal initial alignment algorithms for polar UUV navigation. Results demonstrate that the proposed polar initial alignment algorithm can complete the initial alignment of UUV in the polar region rapidly and accurately. PMID:29168735

  9. The State of the NIH BRAIN Initiative.

    PubMed

    Koroshetz, Walter; Gordon, Joshua; Adams, Amy; Beckel-Mitchener, Andrea; Churchill, James; Farber, Gregory; Freund, Michelle; Gnadt, Jim; Hsu, Nina; Langhals, Nicholas; Lisanby, Sarah; Liu, Guoying; Peng, Grace; Ramos, Khara; Steinmetz, Michael; Talley, Edmund; White, Samantha

    2018-06-19

    The BRAIN Initiative® arose from a grand challenge to "accelerate the development and application of new technologies that will enable researchers to produce dynamic pictures of the brain that show how individual brain cells and complex neural circuits interact at the speed of thought." The BRAIN Initiative is a public-private effort focused on the development and use of powerful tools for acquiring fundamental insights about how information processing occurs in the central nervous system. As the Initiative enters its fifth year, NIH has supported over 500 principal investigators, who have answered the Initiative's challenge via hundreds of publications describing novel tools, methods, and discoveries that address the Initiative's seven scientific priorities. We describe scientific advances produced by individual labs, multi-investigator teams, and entire consortia that, over the coming decades, will produce more comprehensive and dynamic maps of the brain, deepen our understanding of how circuit activity can produce a rich tapestry of behaviors, and lay the foundation for understanding how its circuitry is disrupted in brain disorders. Much more work remains to bring this vision to fruition, and NIH continues to look to the diverse scientific community, from mathematics, to physics, chemistry, engineering, neuroethics, and neuroscience, to ensure that the greatest scientific benefit arises from this unique research Initiative. Copyright © 2018 the authors.

  10. 24 CFR 982.626 - Homeownership option: Initial requirements.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Homeownership option: Initial requirements. 982.626 Section 982.626 Housing and Urban Development Regulations Relating to Housing and Urban... Types Homeownership Option § 982.626 Homeownership option: Initial requirements. (a) List of initial...

  11. 76 FR 6688 - Land Border Carrier Initiative Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-08

    ... [Docket No. USCBP-2006-0132; CBP Dec. No. 11-04] RIN 1651-AA68 Land Border Carrier Initiative Program... Carrier Initiative Program (LBCIP). The LBCIP was established as a voluntary industry partnership program... Initiative Program (LBCIP) was established as a CBP-industry partnership regulatory program enlisting the...

  12. 16 CFR 5.65 - Review of initial decision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Review of initial decision. 5.65 Section 5.65 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE... initial decision. Appeals from the initial decision of the Administrative Law Judge or review by the...

  13. Midwest Clean Diesel Initiative

    EPA Pesticide Factsheets

    The Midwest Clean Diesel Initiative (MCDI) is a collaboration of federal, state and local agencies, along with communities, non-profit organizations and private companies working together by reducing exposure to emissions from diesel engines

  14. The effect of family policies and public health initiatives on breastfeeding initiation among 18 high-income countries: a qualitative comparative analysis research design.

    PubMed

    Lubold, Amanda Marie

    2017-01-01

    The objective of this study is to examine the effects of macro-level factors - welfare state policies and public health initiatives - on breastfeeding initiation among eighteen high-income countries. This study utilizes fuzzy-set Qualitative Comparative Analysis methods to examine the combinations of conditions leading to both high and low national breastfeeding initiation rates among eighteen high-income countries. The most common pathway leading to high breastfeeding initiation is the combination of conditions including a high percentage of women in parliament, a low national cesarean section rate, and either low family spending, high rates of maternity leave, or high rates of women working part-time. The most common pathway leading to low breastfeeding initiation includes the necessary condition of low national adherence to the Baby-Friendly Hospital Initiative. This research suggests that there is a connection between broad level welfare state polices, public health initiatives, and breastfeeding initiation. Compliance with the WHO/UNICEF initiatives depends on welfare regime policies and overall support for women in both productive and reproductive labor.

  15. 42 CFR 417.920 - Planning and initial development.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Planning and initial development. 417.920 Section... and initial development. (a) Under section 1304 of the PHS Act, grants and loan guarantees were awarded for projects for planning and initial development of HMOs. (b) Planning projects included projects...

  16. The Principal Spectrum Runs from Initiators to Responders.

    ERIC Educational Resources Information Center

    Rutherford, William L.

    1990-01-01

    Most principals are either initiators, responders, or managers. Initiators seek out new information, take control of situations, and intervene to support teachers or correct problems. Responders ignore new information, have vague goals, and enact programs initiated by the central office. Manager principals have a hybrid style that generally…

  17. 42 CFR 405.708 - Effect of initial determination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Effect of initial determination. 405.708 Section 405.708 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Under Medicare Part A § 405.708 Effect of initial determination. (a) The initial determination under...

  18. 42 CFR 405.806 - Effect of Initial Determination.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Effect of Initial Determination. 405.806 Section 405.806 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Part B Program § 405.806 Effect of Initial Determination. The initial determination is binding upon all...

  19. RAS Initiative - Community Outreach

    Cancer.gov

    Through community and technical collaborations, workshops and symposia, and the distribution of reference reagents, the RAS Initiative seeks to increase the sharing of knowledge and resources essential to defeating cancers caused by mutant RAS genes.

  20. Antecedents and outcomes of marijuana use initiation during adolescence.

    PubMed

    Ellickson, Phyllis L; Tucker, Joan S; Klein, David J; Saner, Hilary

    2004-11-01

    This study identified similarities and differences in risk factors for marijuana use initiation from grades 7 to 8, grades 8 to 9, and grades 9 to 10, and examined differences between earlier initiates, later initiates, and nonusers on various problem behaviors at grade 10. Longitudinal data were used to examine predictors and outcomes associated with marijuana initiation from grade 7 (N = 1,955) to grade 10 (N = 909). Participants completed yearly surveys to assess problem behaviors, social influences, and marijuana-related attitudes and behavior. Earlier initiates were more likely than later initiates to exhibit problem-related marijuana use, hard drug use, polydrug use, poor grades, and low academic intentions at grade 10. Across ages, initiation was predicted by smoking, frequency of marijuana offers, and poor grades. Results provided some evidence for a shift from familial to peer influence on marijuana initiation with increasing age. Marijuana-related beliefs were relatively weak predictors of initiation at all ages after controlling for pro-marijuana social influences and engagement in other types of substance use and delinquent behavior. Results emphasize the importance of early intervention and identify a wide range of potentially modifiable risk factors that may be targeted.

  1. 5 CFR 1201.111 - Initial decision by judge.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Initial decision by judge. 1201.111... PRACTICES AND PROCEDURES Procedures for Appellate Cases Final Decisions § 1201.111 Initial decision by judge. (a) The judge will prepare an initial decision after the record closes, and will serve that decision...

  2. Initial Symptoms of ALS

    MedlinePlus

    ... Chapters Certified Centers and Clinics Support Groups About ALS About Us Our Research In Your Community Advocate ... Diagnosis En español Symptoms The initial symptoms of ALS can be quite varied in different people. One ...

  3. ACHP | News | President Obama Launches America's Great Outdoors Initiative

    Science.gov Websites

    Initiative President Obama Launches America's Great Outdoors Initiative President Barack Obama signed a Presidential Memorandum April 16, 2010, establishing the America's Great Outdoors Initiative to promote and Environmental Quality (CEQ) to lead the initiative, in coordination with the Departments of Defense, Commerce

  4. Initial development of 5D COGENT

    NASA Astrophysics Data System (ADS)

    Cohen, R. H.; Lee, W.; Dorf, M.; Dorr, M.

    2015-11-01

    COGENT is a continuum gyrokinetic edge code being developed by the by the Edge Simulation Laboratory (ESL) collaboration. Work to date has been primarily focussed on a 4D (axisymmetric) version that models transport properties of edge plasmas. We have begun development of an initial 5D version to study edge turbulence, with initial focus on kinetic effects on blob dynamics and drift-wave instability in a shearless magnetic field. We are employing compiler directives and preprocessor macros to create a single source code that can be compiled in 4D or 5D, which helps to ensure consistency of physics representation between the two versions. A key aspect of COGENT is the employment of mapped multi-block grid capability to handle the complexity of diverter geometry. It is planned to eventually exploit this capability to handle magnetic shear, through a series of successively skewed unsheared grid blocks. The initial version has an unsheared grid and will be used to explore the degree to which a radial domain must be block decomposed. We report on the status of code development and initial tests. Work performed for USDOE, at LLNL under contract DE-AC52-07NA27344.

  5. Play Initiating Behaviors and Responses in Red Colobus Monkeys

    ERIC Educational Resources Information Center

    Worch, Eric A.

    2012-01-01

    Red colobus monkeys are playful primates, making them an important species in which to study animal play. The author examines play behaviors and responses in the species for its play initiation events, age differences in initiating frequency and initiating behavior, and the types of social play that result from specific initiating behaviors. Out…

  6. Correlates of sexual initiation among European adolescents

    PubMed Central

    Carli, Vladimir; Hadlaczky, Gergö; Sarchiapone, Marco; Apter, Alan; Balazs, Judit; Banzer, Raphaela; Bobes, Julio; Brunner, Romuald; Cosman, Doina; Farkas, Luca; Haring, Christian; Hoven, Christina W.; Kaess, Michael; Kahn, Jean Pierre; McMahon, Elaine; Postuvan, Vita; Sisask, Merike; Värnik, Airi; Zadravec Sedivy, Nusa; Wasserman, Danuta

    2018-01-01

    Background Sexuality is a physiological component of adolescent development, though early initiation is associated with reproductive health risk. This study aimed at identifying correlates and predictors of sexual initiation in a large multinational cohort of European adolescents. Methods A questionnaire addressing socio-demographics, behaviours, mental health and sexual activity, was delivered to 11,110 adolescents recruited from 168 randomly selected schools in 10 European countries between 2009 and 2011. A follow-up questionnaire was delivered after 12 months. The longitudinal association of baseline risk behaviors, psychological attributes and contextual vulnerabilities, with sexual initiation during follow-up was evaluated through simple and multivariable age/sex stratified logistic regression. Multinomial logistic regression measured the association between predictors and sexual initiation with or without coexisting reproductive risk factors, such as multiple partners or infrequent condom use. Results Baseline sexual experience was reported by 19.2% of 10,757 respondents (median age 15; IQR 14–15; females 59.6%). This was significantly more frequent among pupils older than 15 (41%) and males (20.8%). Of 7,111 pupils without previous experience who were available at follow-up (response rate 81.8%), 17% reported sexual initiation, without differences between females and males. Baseline smoking (age/sex adjusted odds ratio [aOR] 3.63), alcohol use (aOR 2.95), illegal drugs use (aOR 2.72), and poor sleep (aOR 1.71) predicted sexual initiation. Stratified analyses showed a particularly strong association in case of younger and female pupils, and, among girls, when initiation was reported together with multiple partners and/or infrequent condom use. Externalizing (i.e. conduct and hyperactivity) symptoms independently predicted sexual initiation. Internalizing difficulties (i.e. emotional and peer problems) were negatively associated with early and risky sexual

  7. [WHO Healthy City Initiative in Japan].

    PubMed

    Yoshizawa, Kazuko

    2013-01-01

    City environmental conditions are associated with health outcomes in people living there. World Health Organization (WHO) initiated Healthy City in 1986. To promote the networking, Alliance for Healthy Cities (AFHC) was launched in 2003 with local offices including AFHC Japan. As of 2010, 26 cities are members of AFHC Japan. A questionnaire was sent to those member cities. It includes questions on why they became an AFHC member, which section is in charge of the initiatives, what factors are important for promotion, and others. Out of the 26 cities, 13 cities returned the completed questionnaire. As for factors important for promoting the initiatives, 10 (77%) out of the 13 cities answered "consciousness of residents", while five (38%) chose "budget". This result suggests that community participation is a more important factor than budget for promoting and succeeding in the initiatives. Aging is a problem in any of the member cities, and six cities out the 13 falls under the category of superaged society, which is defined as a society with the proportion of aged people < 65 years being greater than 21% of the whole population. Eleven cities (85%) agreed that bicycles are an alternative means of transportation to cars; however, infrastructure for ensuring safety needs further improvement. In the promotion of Healthy City, networking among the member cities in Japan and worldwide should be promoted. Community participation with empowerment from the planning stage should lead to sustainable initiatives. The function of AFHC in collaboration among the members should be strengthened to cope with the rapidly changing city environment.

  8. Initial Validation of Ballistic Shock Transducers

    DTIC Science & Technology

    2017-06-05

    objective of this TOP is to describe various methods and instrumentation used in the initial validation of accelerometers to be used in both Ballistic...MILITARY STANDARD 810G CHANGE NOTICE 1, METHOD 522.2, SECTION 4.4.2 ....................................... A-1 B. GLOSSARY...Procedure (TOP) is to describe various methods and instrumentation used in the initial validation of accelerometers to be used in both Ballistic

  9. Operational Initiative in Theory and Doctrine

    DTIC Science & Technology

    2015-05-21

    1984 Paret translation of On War uses the term initiative with far more frequency than the original German text ; given that Paret contextually...logical evolution of thought throughout doctrine, from core texts and dominant military theory prior to 1905 through the current catalogued system...Unfortunately, no such cohesive map currently exists; rather, military theorists have charted the terrain of initiative piecemeal. This section seeks to

  10. National Plant Genome Initiative: 2003-2008

    DTIC Science & Technology

    2003-01-01

    maize, wheat, barley and sorghum. ! New fundamental science discoveries including: (1) the structure and organization of centromeres in higher plants ...JAN 2003 2. REPORT TYPE 3. DATES COVERED 00-00-2003 to 00-00-2003 4. TITLE AND SUBTITLE National Plant Genome Initiative: 2003-2008 5a...National Science Foundation. National Plant Genome Initiative: 2003 - 2008 National Science and Technology Council Committee on Science Interagency

  11. Automatic initialization for 3D bone registration

    NASA Astrophysics Data System (ADS)

    Foroughi, Pezhman; Taylor, Russell H.; Fichtinger, Gabor

    2008-03-01

    In image-guided bone surgery, sample points collected from the surface of the bone are registered to the preoperative CT model using well-known registration methods such as Iterative Closest Point (ICP). These techniques are generally very sensitive to the initial alignment of the datasets. Poor initialization significantly increases the chances of getting trapped local minima. In order to reduce the risk of local minima, the registration is manually initialized by locating the sample points close to the corresponding points on the CT model. In this paper, we present an automatic initialization method that aligns the sample points collected from the surface of pelvis with CT model of the pelvis. The main idea is to exploit a mean shape of pelvis created from a large number of CT scans as the prior knowledge to guide the initial alignment. The mean shape is constant for all registrations and facilitates the inclusion of application-specific information into the registration process. The CT model is first aligned with the mean shape using the bilateral symmetry of the pelvis and the similarity of multiple projections. The surface points collected using ultrasound are then aligned with the pelvis mean shape. This will, in turn, lead to initial alignment of the sample points with the CT model. The experiments using a dry pelvis and two cadavers show that the method can align the randomly dislocated datasets close enough for successful registration. The standard ICP has been used for final registration of datasets.

  12. 42 CFR 417.930 - Initial costs of operation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Initial costs of operation. 417.930 Section 417.930... PREPAYMENT PLANS Administration of Outstanding Loans and Loan Guarantees § 417.930 Initial costs of operation. Under section 1305 of the PHS, loans and loan guarantees were awarded for initial costs of operation of...

  13. Translation Initiation Factor eIF4B Interacts with a Picornavirus Internal Ribosome Entry Site in both 48S and 80S Initiation Complexes Independently of Initiator AUG Location

    PubMed Central

    Ochs, Kerstin; Rust, René C.; Niepmann, Michael

    1999-01-01

    Most eukaryotic initiation factors (eIFs) are required for internal translation initiation at the internal ribosome entry site (IRES) of picornaviruses. eIF4B is incorporated into ribosomal 48S initiation complexes with the IRES RNA of foot-and-mouth disease virus (FMDV). In contrast to the weak interaction of eIF4B with capped cellular mRNAs and its release upon entry of the ribosomal 60S subunit, eIF4B remains tightly associated with the FMDV IRES during formation of complete 80S ribosomes. Binding of eIF4B to the IRES is energy dependent, and binding of the small ribosomal subunit to the IRES requires the previous energy-dependent association of initiation factors with the IRES. The interaction of eIF4B with the IRES in 48S and 80S complexes is independent of the location of the initiator AUG and thus independent of the mechanism by which the small ribosomal subunit is placed at the actual start codon, either by direct internal ribosomal entry or by scanning. eIF4B does not greatly rearrange its binding to the IRES upon entry of the ribosomal subunits, and the interaction of eIF4B with the IRES is independent of the polypyrimidine tract-binding protein, which enhances FMDV translation. PMID:10438840

  14. Health professionals' attitudes towards suicide prevention initiatives.

    PubMed

    Brunero, S; Smith, J; Bates, E; Fairbrother, G

    2008-09-01

    Preventing suicide can depend upon the ability of a range of different health professionals to make accurate suicide risk assessments and treatment plans. The attitudes that clinicians hold towards suicide prevention initiatives may influence their suicide risk assessment and management skills. This study measures a group of non-mental health professionals' attitude towards suicide prevention initiatives. Health professionals that had attended suicide prevention education showed significantly more positive attitudes towards suicide prevention initiatives. The findings in this study further support the effectiveness of educating non-mental health professionals in suicide risk awareness and management.

  15. Advanced Concepts Research Initiative

    EPA Science Inventory

    This initiative is investigating various approaches to controlling and treating wet-weather flow (WWF) discharges in the urban watershed. WWF, including combined sewer overflow (CSO), sanitary sewer overflow (SSO) and stormwater discharges are leading causes of receiving water q...

  16. 42 CFR 414.313 - Initial method of payment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 3 2011-10-01 2011-10-01 false Initial method of payment. 414.313 Section 414.313... Charges Under the ESRD Program § 414.313 Initial method of payment. (a) Basic rule. Under this method, the... vaccine. (c) Physician election of the initial method. (1) Each physician in a facility must submit to the...

  17. Providing a Virtual Initiation for Epsilon Pi Tau

    ERIC Educational Resources Information Center

    Sanders, Craig S.; Griffin, Kathryn M.

    2005-01-01

    One of the requirements of the Epsilon Pi Tau (EPT) initiation is the apprentice has to physically be at the initiation (EPT, 2004). Since the majority of nontraditional students and working professionals are physically removed from an initiation site, they have missed the opportunity to join EPT. On 8 April, 2005, the Beta Mu Chapter of The…

  18. Diversity initiatives in academic psychiatry: applying cultural competence.

    PubMed

    Lim, Russell F; Luo, John S; Suo, Shannon; Hales, Robert E

    2008-01-01

    This article describes the process of change in an academic department of psychiatry that has led to the development of a diversity initiative in teaching, research, recruitment, and services. The authors performed a literature review of diversity initiatives using PubMed. The authors then wrote a case study of the development of a diversity initiative at UC Davis. Some articles on diversity initiatives were found, but none that detailed the administrative process, funding, or sustainability of such initiatives. In 1999, the UC Davis Department of Psychiatry and Behavioral Sciences recognized the importance of issues of diversity and established the Diversity Advisory Committee, a group of department faculty and residents that explores and addresses the diversity needs of the department. In our observations, there are at least three requirements for a successful diversity initiative: a diverse patient population, a "critical mass" of interested faculty, and support of the administration. With these three factors in place, the Diversity Advisory Committee produced four Continuing Medical Education symposia focused on diversity topics, developed a 4-year cultural psychiatry curriculum and a 4-year religion and spirituality curriculum within the residency, and supported nine residents who received awards from the APA's Minority Fellowships in 8 years. Future plans include department-wide and medical school faculty-wide diversity training, educational research, and a postgraduate fellowship in cultural psychiatry. This article shows that a diversity initiative can be undertaken with interested minority and nonminority faculty, administrative support, and a diverse patient population. The authors hope this article will provide assistance to other academic departments in developing diversity initiatives.

  19. The initiation of metabolic inflammation in childhood obesity.

    PubMed

    Singer, Kanakadurga; Lumeng, Carey N

    2017-01-03

    An understanding of the events that initiate metabolic inflammation (metainflammation) can support the identification of targets for preventing metabolic disease and its negative effects on health. There is ample evidence demonstrating that the initiating events in obesity-induced inflammation start early in childhood. This has significant implications on our understanding of how early life events in childhood influence adult disease. In this Review we frame the initiating events of metainflammation in the context of child development and discuss what this reveals about the mechanisms by which this unique form of chronic inflammation is initiated and sustained into adulthood.

  20. The initiation of metabolic inflammation in childhood obesity

    PubMed Central

    2017-01-01

    An understanding of the events that initiate metabolic inflammation (metainflammation) can support the identification of targets for preventing metabolic disease and its negative effects on health. There is ample evidence demonstrating that the initiating events in obesity-induced inflammation start early in childhood. This has significant implications on our understanding of how early life events in childhood influence adult disease. In this Review we frame the initiating events of metainflammation in the context of child development and discuss what this reveals about the mechanisms by which this unique form of chronic inflammation is initiated and sustained into adulthood. PMID:28045405

  1. Successful integration of ergonomics into continuous improvement initiatives.

    PubMed

    Monroe, Kimberly; Fick, Faye; Joshi, Madina

    2012-01-01

    Process improvement initiatives are receiving renewed attention by large corporations as they attempt to reduce manufacturing costs and stay competitive in the global marketplace. These initiatives include 5S, Six Sigma, and Lean. These programs often take up a large amount of available time and budget resources. More often than not, existing ergonomics processes are considered separate initiatives by upper management and struggle to gain a seat at the table. To effectively maintain their programs, ergonomics program managers need to overcome those obstacles and demonstrate how ergonomics initiatives are a natural fit with continuous improvement philosophies.

  2. Initiation of Detonation in Multiple Shock-Compressed Liquid Explosives

    NASA Astrophysics Data System (ADS)

    Yoshinaka, A. C.; Zhang, F.; Petel, O. E.; Higgins, A. J.

    2006-07-01

    Initiation and resulting propagation of detonation via multiple shock reverberations between two high impedance plates has been investigated in amine-sensitized nitromethane. Experiments were designed so that the first reflected shock strength was below the critical value for initiation found previously. Luminosity combined with a distinct pressure hump indicated onset of reaction and successful initiation after double or triple shock reflection off the bottom plate. Final temperature estimates for double or triple shock reflection immediately before initiation lie between 700-720 K, consistent with those found previously for both incident and singly reflected shock initiation.

  3. Near Term Capacity Initiatives

    DOT National Transportation Integrated Search

    1992-07-01

    One of the major aviation challenges in recent years has been the increase in : the number and duration of flight delays. This pamphlet offers the reader a : description of near-term capacity initiatives, their intended purpose, an : indication of wh...

  4. 43 CFR 2711.1 - Initiation of sale.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Initiation of sale. 2711.1 Section 2711.1..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SALES: FEDERAL LAND POLICY AND MANAGEMENT ACT Sales: Procedures § 2711.1 Initiation of sale. ...

  5. 43 CFR 2711.1 - Initiation of sale.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Initiation of sale. 2711.1 Section 2711.1..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SALES: FEDERAL LAND POLICY AND MANAGEMENT ACT Sales: Procedures § 2711.1 Initiation of sale. ...

  6. 43 CFR 2711.1 - Initiation of sale.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Initiation of sale. 2711.1 Section 2711.1..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) SALES: FEDERAL LAND POLICY AND MANAGEMENT ACT Sales: Procedures § 2711.1 Initiation of sale. ...

  7. 30 CFR 57.6501 - Nonelectric initiation systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... nonelectric initiation system uses shock tube— (1) Connections with other initiation devices shall be secured... which detonation is to proceed; (5) Connections between blastholes shall not be made until immediately... use gas tube, continuity of the circuit shall be tested prior to blasting. ...

  8. 30 CFR 57.6501 - Nonelectric initiation systems.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... nonelectric initiation system uses shock tube— (1) Connections with other initiation devices shall be secured... which detonation is to proceed; (5) Connections between blastholes shall not be made until immediately... use gas tube, continuity of the circuit shall be tested prior to blasting. ...

  9. 30 CFR 57.6501 - Nonelectric initiation systems.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... nonelectric initiation system uses shock tube— (1) Connections with other initiation devices shall be secured... which detonation is to proceed; (5) Connections between blastholes shall not be made until immediately... use gas tube, continuity of the circuit shall be tested prior to blasting. ...

  10. 30 CFR 57.6501 - Nonelectric initiation systems.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... nonelectric initiation system uses shock tube— (1) Connections with other initiation devices shall be secured... which detonation is to proceed; (5) Connections between blastholes shall not be made until immediately... use gas tube, continuity of the circuit shall be tested prior to blasting. ...

  11. 30 CFR 57.6501 - Nonelectric initiation systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... nonelectric initiation system uses shock tube— (1) Connections with other initiation devices shall be secured... which detonation is to proceed; (5) Connections between blastholes shall not be made until immediately... use gas tube, continuity of the circuit shall be tested prior to blasting. ...

  12. Mixed-Initiative Planning in MAPGEN: Capabilities and Shortcomings

    NASA Technical Reports Server (NTRS)

    Bresina, John L.; Jonsson, Ari K.; Morris, Paul H.; Rajan, Kanna

    2005-01-01

    MAPGEN (Mixed-initiative Activity Plan GENerator) is a mixed-initiative system that employs automated constraint-based planning, scheduling, and temporal reasoning to assist the Mars Exploration Rover mission operations staff in generating the daily activity plans. This paper describes the mixed-initiative capabilities of MAPGEN, identifies shortcomings with the deployed system, and discusses ongoing work to address some of these shortcomings.

  13. Initiation of Insensitive High Explosives Using Multiple Wave Interactions

    NASA Astrophysics Data System (ADS)

    Francois, Elizabeth

    Insensitive High Explosives (IHEs) increase safety in many types of weapons. However, the safety comes at the cost of performance. Initiation of IHE requires large boosters and powerful detonators as well. Multipoint initiation is being utilized to exploit explosive wave interactions to create overdriven states, greatly facilitating the initiation of IHEs. This presentation will focus on recent explosive experiments where the minimum spot size for single-point initiation in PBX 9502 was determined. Below this threshold, PBX 9502 could not be initiated. This was then expanded to three initiation points, which were smaller this threshold. Measurements of the velocity and pressure of the wave interactions were measured using Photon Doppler Velocimetry (PDV). Initiation was observed, and the resulting pressures at the double and triple points were found to be above the CJ state for PBX 9502. Further testing will be performed using cutback experiments to isolate the overdriven state, and quantify the duration of the phenomenon.

  14. Initiation of Insensitive High Explosives Using Multiple Wave Interactions

    NASA Astrophysics Data System (ADS)

    Francois, Elizabeth; Burritt, Rosmary; Biss, Matt; Bowden, Patrick

    2017-06-01

    Insensitive High Explosives (IHEs) increase safety in many types of weapons. However, the safety comes at the cost of performance. Initiation of IHE requires large boosters and powerful detonators as well. Multipoint initiation is being utilized to exploit explosive wave interactions to create overdriven states, greatly facilitating the initiation of IHEs. This presentation will build from recent explosive experiments where the minimum spot size for single-point initiation in PBX 9502 was determined. Below this threshold, PBX 9502 could not be initiated. This was then expanded to three initiation points, which were smaller this threshold. Measurements of the velocity and pressure of the wave interactions were measured using Photon Doppler Velocimetry (PDV). Initiation was observed, and the resulting pressures at the double and triple points were found to be above the CJ state for PBX 9502. Based on these results, further tests were conducted to isolate and measure the longevity and pressure of this phenomenon using cut-back tests. All results will be presented and discussed.

  15. Identification of cells initiating human melanomas.

    PubMed

    Schatton, Tobias; Murphy, George F; Frank, Natasha Y; Yamaura, Kazuhiro; Waaga-Gasser, Ana Maria; Gasser, Martin; Zhan, Qian; Jordan, Stefan; Duncan, Lyn M; Weishaupt, Carsten; Fuhlbrigge, Robert C; Kupper, Thomas S; Sayegh, Mohamed H; Frank, Markus H

    2008-01-17

    Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for tumour growth, have been identified in human haematological malignancies and solid cancers. If such minority populations are associated with tumour progression in human patients, specific targeting of tumour-initiating cells could be a strategy to eradicate cancers currently resistant to systemic therapy. Here we identify a subpopulation enriched for human malignant-melanoma-initiating cells (MMIC) defined by expression of the chemoresistance mediator ABCB5 (refs 7, 8) and show that specific targeting of this tumorigenic minority population inhibits tumour growth. ABCB5+ tumour cells detected in human melanoma patients show a primitive molecular phenotype and correlate with clinical melanoma progression. In serial human-to-mouse xenotransplantation experiments, ABCB5+ melanoma cells possess greater tumorigenic capacity than ABCB5- bulk populations and re-establish clinical tumour heterogeneity. In vivo genetic lineage tracking demonstrates a specific capacity of ABCB5+ subpopulations for self-renewal and differentiation, because ABCB5+ cancer cells generate both ABCB5+ and ABCB5- progeny, whereas ABCB5- tumour populations give rise, at lower rates, exclusively to ABCB5- cells. In an initial proof-of-principle analysis, designed to test the hypothesis that MMIC are also required for growth of established tumours, systemic administration of a monoclonal antibody directed at ABCB5, shown to be capable of inducing antibody-dependent cell-mediated cytotoxicity in ABCB5+ MMIC, exerted tumour-inhibitory effects. Identification of tumour-initiating cells with enhanced abundance in more advanced disease but susceptibility to specific targeting through a defining chemoresistance determinant has important implications for cancer therapy.

  16. Identification of cells initiating human melanomas

    PubMed Central

    Schatton, Tobias; Murphy, George F.; Frank, Natasha Y.; Yamaura, Kazuhiro; Waaga-Gasser, Ana Maria; Gasser, Martin; Zhan, Qian; Jordan, Stefan; Duncan, Lyn M.; Weishaupt, Carsten; Fuhlbrigge, Robert C.; Kupper, Thomas S.; Sayegh, Mohamed H.; Frank, Markus H.

    2012-01-01

    Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for tumour growth, have been identified in human haematological malignancies1,2 and solid cancers3–6. If such minority populations are associated with tumour progression in human patients, specific targeting of tumour-initiating cells could be a strategy to eradicate cancers currently resistant to systemic therapy. Here we identify a subpopulation enriched for human malignant-melanoma-initiating cells (MMIC) defined by expression of the chemoresistance mediator ABCB5 (refs 7, 8) and show that specific targeting of this tumorigenic minority population inhibits tumour growth. ABCB5+ tumour cells detected in human melanoma patients show a primitive molecular phenotype and correlate with clinical melanoma progression. In serial human-to-mouse xenotransplantation experiments, ABCB5+ melanoma cells possess greater tumorigenic capacity than ABCB5− bulk populations and re-establish clinical tumour heterogeneity. In vivo genetic lineage tracking demonstrates a specific capacity of ABCB5+ sub-populations for self-renewal and differentiation, because ABCB5+ cancer cells generate both ABCB5+ and ABCB5− progeny, whereas ABCB5− tumour populations give rise, at lower rates, exclusively to ABCB5− cells. In an initial proof-of-principle analysis, designed to test the hypothesis that MMIC are also required for growth of established tumours, systemic administration of a monoclonal antibody directed at ABCB5, shown to be capable of inducing antibody-dependent cell-mediated cytotoxicity in ABCB5+ MMIC, exerted tumour-inhibitory effects. Identification of tumour-initiating cells with enhanced abundance in more advanced disease but susceptibility to specific targeting through a defining chemoresistance determinant has important implications for cancer therapy. PMID:18202660

  17. The initial regime of drop coalescence

    NASA Astrophysics Data System (ADS)

    Anthony, Christopher; Harris, Michael; Basaran, Osman

    2017-11-01

    Drop coalescence plays a key role in both industry and nature. Consequently, study of the phenomenon has been the focus of numerous experimental, computational and theoretical works to date. In coalescence, two drops come into contact and a liquid bridge forms between them. As time advances, this bridge grows from microscopic to macroscopic scales. Despite the large volume of work dedicated to this problem, currently experiment, theory, and computation are not in perfect agreement with respect to the earliest times following the initial contact of the drops. Experiments report an initial regime where the radius of the connecting bridge grows linearly in time before a transition to either a Stokes regime or an inertial regime where either viscous or inertial forces balance capillary force. In the initial linear regime, referred to as the inertially-limited viscous regime, all three forces are thought to be important. This is in contrast to theory which predicts that all coalescence events begin in the Stokes regime. We use high accuracy numerical simulation to show that the existing discrepancy in the literature can be resolved by paying careful attention to the initial conditions that set the shape and size of the bridge connecting the two drops.

  18. 14 CFR 60.15 - Initial qualification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Initial qualification requirements. 60.15 Section 60.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.15...

  19. 14 CFR 60.15 - Initial qualification requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Initial qualification requirements. 60.15 Section 60.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.15...

  20. 14 CFR 60.15 - Initial qualification requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Initial qualification requirements. 60.15 Section 60.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.15...

  1. 14 CFR 60.15 - Initial qualification requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Initial qualification requirements. 60.15 Section 60.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.15...

  2. 14 CFR 60.15 - Initial qualification requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Initial qualification requirements. 60.15 Section 60.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.15...

  3. 75 FR 49510 - Credit Watch Termination Initiative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5411-N-02] Credit Watch Termination Initiative AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner, HUD. ACTION... FHA Credit Watch Termination Initiative. This notice includes a list of mortgagees which have had...

  4. 75 FR 17944 - Credit Watch Termination Initiative

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5411-N-01] Credit Watch Termination Initiative AGENCY: Office of the Assistant Secretary for Housing--Federal Housing Commissioner, HUD. ACTION... FHA Credit Watch Termination Initiative. This notice includes a list of mortgagees which have had...

  5. 16 CFR 5.53 - Initiation of investigation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Initiation of investigation. 5.53 Section 5.53 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE STANDARDS OF CONDUCT Disciplinary Actions Concerning Postemployment Conflict of Interest § 5.53 Initiation...

  6. 23 CFR 630.403 - Initiation of projects.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Initiation of projects. 630.403 Section 630.403 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS PRECONSTRUCTION PROCEDURES Geodetic Markers § 630.403 Initiation of projects. All projects shall be coordinated by...

  7. 24 CFR 220.801 - Initial insurance endorsement.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Initial insurance endorsement. 220.801 Section 220.801 Housing and Urban Development Regulations Relating to Housing and Urban... AREAS Contract Rights and Obligations-Projects Insured Project Improvement Loans § 220.801 Initial...

  8. Clean Energy Manufacturing Initiative

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    2013-04-01

    The initiative will strategically focus and rally EERE’s clean energy technology offices and Advanced Manufacturing Office around the urgent competitive opportunity for the United States to be the leader in the clean energy manufacturing industries and jobs of today and tomorrow.

  9. Addison disease - diagnosis and initial management.

    PubMed

    O'Connell, Susan; Siafarikas, Aris

    2010-11-01

    Adrenal insufficiency is a rare disease caused by either primary adrenal failure (Addison disease) or by impairment of the hypothalamic-pituitary-adrenal axis. Steroid replacement therapy normalises quality of life, however, adherence can be problematic. This article provides information on adrenal insufficiency focusing on awareness of initial symptoms and on risk scenarios, emergency management and baseline investigations, complete investigations and long term management. Early recognition of adrenal insufficiency is essential to avoid associated morbidity and mortality. Initial diagnosis and decision to treat are based on history and physical examination. Appropriate management includes emergency resuscitation and steroid administration. Initial investigations can include sodium, potassium and blood glucose levels. However, complete investigations can be deferred. Specialist advice should be obtained and long term management includes a Team Care Arrangement. For patients, an emergency plan and emergency identification are essential.

  10. Global peatland initiation driven by regionally asynchronous warming.

    PubMed

    Morris, Paul J; Swindles, Graeme T; Valdes, Paul J; Ivanovic, Ruza F; Gregoire, Lauren J; Smith, Mark W; Tarasov, Lev; Haywood, Alan M; Bacon, Karen L

    2018-05-08

    Widespread establishment of peatlands since the Last Glacial Maximum represents the activation of a globally important carbon sink, but the drivers of peat initiation are unclear. The role of climate in peat initiation is particularly poorly understood. We used a general circulation model to simulate local changes in climate during the initiation of 1,097 peatlands around the world. We find that peat initiation in deglaciated landscapes in both hemispheres was driven primarily by warming growing seasons, likely through enhanced plant productivity, rather than by any increase in effective precipitation. In Western Siberia, which remained ice-free throughout the last glacial period, the initiation of the world's largest peatland complex was globally unique in that it was triggered by an increase in effective precipitation that inhibited soil respiration and allowed wetland plant communities to establish. Peat initiation in the tropics was only weakly related to climate change, and appears to have been driven primarily by nonclimatic mechanisms such as waterlogging due to tectonic subsidence. Our findings shed light on the genesis and Holocene climate space of one of the world's most carbon-dense ecosystem types, with implications for understanding trajectories of ecological change under changing future climates.

  11. CubeSat Initiatives at KSC

    NASA Technical Reports Server (NTRS)

    Berg, Jared J.

    2014-01-01

    Even though the Small PayLoad Integrated Testing Services or SPLITS line of business is newly established, KSC has been involved in a variety of CubeSat projects and programs. CubeSat development projects have been initiated through educational outreach partnerships with schools and universities, commercial partnerships and internal training initiatives. KSC has also been involved in CubeSat deployment through programs to find launch opportunities to fly CubeSats as auxiliary payloads on previously planned missions and involvement in the development of new launch capabilities for small satellites. This overview will highlight the CubeSat accomplishments at KSC and discuss planning for future projects and opportunities.

  12. Modeling initiation trains based on HMX and TATB

    NASA Astrophysics Data System (ADS)

    Drake, R. C.; Maisey, M.

    2017-01-01

    There will always be a requirement to reduce the size of initiation trains. However, as the size is reduced the performance characteristics can be compromised. A detailed science-based understanding of the processes (ignition and growth to detonation) which determine the performance characteristics is required to enable compact and robust initiation trains to be designed. To assess the use of numerical models in the design of initiation trains a modeling study has been undertaken, with the aim of understanding the initiation of TATB and HMX charges by a confined, surface mounted detonator. The effect of detonator diameter and detonator confinement on the formation of dead zones in the acceptor explosives has been studied. The size of dead zones can be reduced by increasing the diameter of the detonator and by increasing the impedance of the confinement. The implications for the design of initiation trains are discussed.

  13. Electrical tree initiation in polyethylene absorbing Penning gas

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shimizu, N.; Tohyama, N.; Sato, H.

    1996-12-31

    Ac tree initiation voltage was examined in untreated LDPE, vacuum degassed LDPE and LDPE absorbing He gas (He gas was absorbed after vacuum degassing). The authors have already reported that vacuum degassed LDPE shows much higher tree initiation voltage than untreated one because of absence of oxygen. Therefore they expected that LDPE absorbing He shows the same property with vacuum degassed LDPE. However tree initiation voltage of LDPE absorbing He is as low as that of untreated LDPE. LDPE absorbing Ar gas shows the same tendency. He or Ar gas does not change so much impulse tree initiation voltage. LDPEmore » absorbing He was not well dyed with methylene blue after ac voltage application, which indicates that active oxidation does not occur. Low ac tree initiation voltage in LDPE absorbing He or Ar may be caused by Penning ionization in free volume.« less

  14. Initiative-Oriented Training.

    DTIC Science & Technology

    1998-06-05

    Conditions, and Standards Prior to STXs 70 13. Knowledge of the Enemy Situation Prior to STXs 71 14. Frequency of MILES Free - Play Exercises 72...in addition to realistic sights, sounds, and smells. With regards to force-on-force, or free - play MILES exercises, uncertainty and initiative can...sounds, and (to some degree) smells of the battlefield; use MILES force-on-force, free - play exercises to incorporate cognitive mental Stressors and

  15. Phoenix Violence Prevention Initiative, Phase II Report.

    ERIC Educational Resources Information Center

    Waits, Mary Jo; Johnson, Ryan; Kornreich, Toby; Klym, Mark; Leland, Karen

    In 1996, drawing from religious, educational, social services, media, neighborhoods, nonprofits, and health-providing sectors of the community, the Phoenix Violence Prevention Initiative (PVPI) was conceived. During Phase One of the initiative, the following seven points regarding prevention and prevention design strategies were assembled: (1)…

  16. 37 CFR 351.1 - Initiation of proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the distribution of royalty fees, shall be initiated by publication in the Federal Register of a.... 351.1 Section 351.1 Patents, Trademarks, and Copyrights COPYRIGHT ROYALTY BOARD, LIBRARY OF CONGRESS COPYRIGHT ROYALTY JUDGES RULES AND PROCEDURES PROCEEDINGS § 351.1 Initiation of proceedings. (a) Notice of...

  17. Augmenting Probabilistic Risk Assesment with Malevolent Initiators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Curtis Smith; David Schwieder

    2011-11-01

    As commonly practiced, the use of probabilistic risk assessment (PRA) in nuclear power plants only considers accident initiators such as natural hazards, equipment failures, and human error. Malevolent initiators are ignored in PRA, but are considered the domain of physical security, which uses vulnerability assessment based on an officially specified threat (design basis threat). This paper explores the implications of augmenting and extending existing PRA models by considering new and modified scenarios resulting from malevolent initiators. Teaming the augmented PRA models with conventional vulnerability assessments can cost-effectively enhance security of a nuclear power plant. This methodology is useful for operatingmore » plants, as well as in the design of new plants. For the methodology, we have proposed an approach that builds on and extends the practice of PRA for nuclear power plants for security-related issues. Rather than only considering 'random' failures, we demonstrated a framework that is able to represent and model malevolent initiating events and associated plant impacts.« less

  18. Profiles of Selected Promising Professional Development Initiatives.

    ERIC Educational Resources Information Center

    Cohen, Carol; Gerber, Peter; Handley, Claire; Kronley, Robert; Parry, Megan

    In 2000, the Finance Project received a planning grant to launch a new initiative on financing professional development in education. This report represents efforts to identify and develop a database on promising new approaches to professional development in education, profiling 16 initiatives recommended by knowledge experts and representing a…

  19. European Initiatives in Postgraduate Education in Gerontology

    ERIC Educational Resources Information Center

    van Rijsselt, Rene J. T.; Parkatti, Terttu; Troisi, Joseph

    2007-01-01

    This paper describes three innovative European initiatives in postgraduate education in gerontology. The first is the European Masters Program in Gerontology (EuMaG), developed as an interdisciplinary joint program, supported and delivered by 22 European universities. Second, the Nordplus initiative to increase mobility of students and staff in…

  20. 40 CFR 280.63 - Initial site characterization.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Initial site characterization. 280.63... Hazardous Substances § 280.63 Initial site characterization. (a) Unless directed to do otherwise by the implementing agency, owners and operators must assemble information about the site and the nature of the...

  1. Student Initiatives in Urban Elementary Science Classrooms

    ERIC Educational Resources Information Center

    Lewis, Scott; Lee, Okhee; Santau, Alexandra; Cone, Neporcha

    2010-01-01

    Student initiatives play an important role in inquiry-based science with all students, including English language learning (ELL) students. This study examined initiatives that elementary students made as they participated in an intervention to promote science learning and English language development over a three-year period. In addition, the…

  2. 30 CFR 56.6501 - Nonelectric initiation systems.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... shock tube— (1) Connections with other initiation devices shall be secured in a manner which provides... proceed; (5) Connections between blastholes shall not be made until immediately prior to clearing the... connected to the trunklines at the blast site. (c) When the nonelectric initiation system uses gas tube...

  3. 30 CFR 56.6501 - Nonelectric initiation systems.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... shock tube— (1) Connections with other initiation devices shall be secured in a manner which provides... proceed; (5) Connections between blastholes shall not be made until immediately prior to clearing the... connected to the trunklines at the blast site. (c) When the nonelectric initiation system uses gas tube...

  4. 30 CFR 56.6501 - Nonelectric initiation systems.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... shock tube— (1) Connections with other initiation devices shall be secured in a manner which provides... proceed; (5) Connections between blastholes shall not be made until immediately prior to clearing the... connected to the trunklines at the blast site. (c) When the nonelectric initiation system uses gas tube...

  5. 30 CFR 56.6501 - Nonelectric initiation systems.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... shock tube— (1) Connections with other initiation devices shall be secured in a manner which provides... proceed; (5) Connections between blastholes shall not be made until immediately prior to clearing the... connected to the trunklines at the blast site. (c) When the nonelectric initiation system uses gas tube...

  6. 30 CFR 56.6501 - Nonelectric initiation systems.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... shock tube— (1) Connections with other initiation devices shall be secured in a manner which provides... proceed; (5) Connections between blastholes shall not be made until immediately prior to clearing the... connected to the trunklines at the blast site. (c) When the nonelectric initiation system uses gas tube...

  7. 10 CFR 710.22 - Initial decision process.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) The Manager shall make an initial decision as to the individual's access authorization eligibility... Officer refers the individual's case to the Manager in accordance with § 710.25(e) or § 710.26(b). (b..., the Manager's initial decision as to the individual's access authorization eligibility shall be made...

  8. Implementing Patient Safety Initiatives in Rural Hospitals

    ERIC Educational Resources Information Center

    Klingner, Jill; Moscovice, Ira; Tupper, Judith; Coburn, Andrew; Wakefield, Mary

    2009-01-01

    Implementation of patient safety initiatives can be costly in time and energy. Because of small volumes and limited resources, rural hospitals often are not included in nationally driven patient safety initiatives. This article describes the Tennessee Rural Hospital Patient Safety Demonstration project, whose goal was to strengthen capacity for…

  9. 19 CFR 356.15 - Initiation of proceedings.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... an investigation and report by the Director under § 356.14(c) and consultation with the Chief Counsel... of a FTA country, the Deputy Under Secretary will promptly initiate proceedings under this part by... Deputy Under Secretary's discretion, either initiate a proceeding under this subpart by issuing a...

  10. 19 CFR 356.15 - Initiation of proceedings.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... an investigation and report by the Director under § 356.14(c) and consultation with the Chief Counsel... of a FTA country, the Deputy Under Secretary will promptly initiate proceedings under this part by... Deputy Under Secretary's discretion, either initiate a proceeding under this subpart by issuing a...

  11. Evaluation of a community diabetes initiative: Integrating diabetes care.

    PubMed

    Walsh, Jason Leo; Harris, Benjamin Howell Lole; Roberts, Aled Wyn

    2015-06-01

    To evaluate the impact of a community diabetes initiative, aiming to improve the efficiency of type 2 diabetes (T2DM) care within the Cardiff and Vale Health Board. In 2012, a community diabetes initiative was introduced in Cardiff and Vale. Ten National Health Service (NHS) consultant diabetologists and three nurse specialists supported 69 general practices in this region. Here we evaluate the impact of this initiative by assessing the number and quality of secondary care diabetes clinic referrals before (2011-2012) and after implementation (2013-2014). Referrals pre and post initiative were audited against Cardiff and Vale T2DM referral guidelines in two 6-month periods. In the 6-months prior to the initiative, 108 referrals were received, 78 of which were in line with local guidance. Approximately one year after embarking on the diabetes initiative (2013-2014) there was a 31% reduction (p<0.01) in the total number of T2DM clinic referrals and a 57% reduction (p<0.01) in referrals outside the guidelines. A decrease in referrals was not seen in the practice noted not to engage with the initiative. The community diabetes initiative intervention has significantly improved the appropriateness of T2DM referrals from GP practices engaged with the initiative. As a result we advocate a move towards integrated diabetes care within the community. Copyright © 2014 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.

  12. Financial preconditions for successful community initiatives for the uninsured.

    PubMed

    Song, Paula H; Smith, Dean G

    2007-01-01

    Community-based initiatives are increasingly being implemented as a strategy to address the health needs of the community, with a growing body of evidence on successes of various initiatives. This study addresses financial status indicators (preconditions) that might predict where community-based initiatives might have a better chance for success. We evaluated five community-based initiatives funded by the Communities in Charge (CIC) program sponsored by the Robert Wood Johnson Foundation. These initiatives focus on increasing access by easing financial barriers to care for the uninsured. At each site, we collected information on financial status indicators and interviewed key personnel from health services delivery and financing organizations. With full acknowledgment of the caveats associated with generalizations based on a small number of observations, we suggest four financial preconditions associated with successful initiation of CIC programs: (1) uncompensated care levels that negatively affect profitability, (2) reasonable financial stability of providers, (3) stable health insurance market, and (4) the potential to create new sources of funding. In general, sites that demonstrate successful program initiation are financially stressed enough by uncompensated care to gain the attention of local healthcare providers. However, they are not so strained and so concerned about revenue sources that they cannot afford to participate in the initiative. In addition to political and managerial indicators, we suggest that planning for community-based initiatives should include financial indicators of current health services delivery and financing organizations and consideration of whether they meet preconditions for success.

  13. Initial state with shear in peripheral heavy ion collisions

    NASA Astrophysics Data System (ADS)

    Magas, V. K.; Gordillo, J.; Strottman, D.; Xie, Y. L.; Csernai, L. P.

    2018-06-01

    In the present work we propose a new way of constructing the initial state for further hydrodynamic simulation of relativistic heavy ion collisions based on Bjorken-like solution applied streak by streak in the transverse plane. Previous fluid dynamical calculations in Cartesian coordinates with an initial state based on a streak by streak Yang-Mills field led for peripheral higher energy collisions to large angular momentum, initial shear flow and significant local vorticity. Recent experiments verified the existence of this vorticity via the resulting polarization of emitted Λ and Λ ¯ particles. At the same time parton cascade models indicated the existence of more compact initial state configurations, which we are going to simulate in our approach. The proposed model satisfies all the conservation laws, including conservation of a strong initial angular momentum, which is present in noncentral collisions. As a consequence of this large initial angular momentum we observe the rotation of the whole system as well as the fluid shear in the initial state, which leads to large flow vorticity. Another advantage of the proposed model is that the initial state can be given in both [t,x,y,z] and [τ ,x ,y ,η ] coordinates and thus can be tested by all 3+1D hydrodynamical codes which exist in the field.

  14. Lightweight Combat Vehicle S&T Initiatives

    DTIC Science & Technology

    2015-08-01

    1 U.S. ARMY TANK AUTOMOTIVE RESEARCH, DEVELOPMENT AND ENGINEERING CENTER Lightweight Combat Vehicle S &T Initiatives Dr. Richard Gerth Ground Systems...00-00-2015 to 00-00-2015 4. TITLE AND SUBTITLE Lightweight Combat Vehicle S &T Initiatives Global Automotive Lightweight Materials 2015 - August...18-20 2015 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR( S ) Richard Gerth 5d. PROJECT NUMBER 5e. TASK NUMBER 5f

  15. The Vertical Linear Fractional Initialization Problem

    NASA Technical Reports Server (NTRS)

    Lorenzo, Carl F.; Hartley, Tom T.

    1999-01-01

    This paper presents a solution to the initialization problem for a system of linear fractional-order differential equations. The scalar problem is considered first, and solutions are obtained both generally and for a specific initialization. Next the vector fractional order differential equation is considered. In this case, the solution is obtained in the form of matrix F-functions. Some control implications of the vector case are discussed. The suggested method of problem solution is shown via an example.

  16. Propellant for the NASA Standard Initiator

    NASA Technical Reports Server (NTRS)

    Hohmann, Carl; Tipton, Bill, Jr.; Dutton, Maureen

    2000-01-01

    This paper discusses processes employed in manufacturing zirconium-potassium perchlorate propellant for the NASA standard initiator. It provides both a historical background on the NSI device-detailing problem areas and their resolution--and on propellant blending techniques. Emphasis is placed on the precipitation blending method. The findings on mixing equipment, processing, and raw materials are described. Also detailed are findings on the bridgewire slurry operation, one of the critical steps in the production of the NASA standard initiator.

  17. Creating structure for continuation of initiatives.

    PubMed

    McClave, Stephen A; Mechanick, Jeffrey I; Kushner, Robert F; DeLegge, Mark H

    2010-01-01

    The Summit for Increasing Physician Nutrition Experts brought nutrition leaders from North America together to forge new strategies for promoting greater physician involvement in clinical nutrition. The initiatives derived from the Summit address issues related to education, board certification, research, and clinical practice. To seek consensus from participating societies and to establish a format for the implementation of these initiatives, a council of representatives needs to be formed. The council must be noncompetitive, promote collaboration and facilitation of nutrition activities for participating societies, and ultimately provide service to the healthcare system and individual practitioners. The structure of this council may evolve from a temporary task force to an enduring committee. Participating societies will be asked to fund expenses for their representative and host council meetings on a rotating basis. The council will assume responsibility for pursuing Summit initiatives and providing ongoing communication and collaboration between participant groups.

  18. 40 CFR 75.20 - Initial certification and recertification procedures.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... all applicable initial certification tests under paragraph (c) of this section are completed by the... installed, initial certification is required. (1) Notification of initial certification test dates. The...) tests. (4) Certification (or recertification) application formal approval process. The Administrator...

  19. 40 CFR 75.20 - Initial certification and recertification procedures.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... all applicable initial certification tests under paragraph (c) of this section are completed by the... installed, initial certification is required. (1) Notification of initial certification test dates. The...) tests. (4) Certification (or recertification) application formal approval process. The Administrator...

  20. 40 CFR 75.20 - Initial certification and recertification procedures.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... all applicable initial certification tests under paragraph (c) of this section are completed by the... installed, initial certification is required. (1) Notification of initial certification test dates. The...) tests. (4) Certification (or recertification) application formal approval process. The Administrator...

  1. Universal Surface-initiated Polymerization of Antifouling Zwitterionic Brushes Using A Mussel-Mimetic Peptide Initiator

    PubMed Central

    Kuang, Jinghao; Messersmith, Phillip B.

    2012-01-01

    We report a universal method for the surface-initated polymerization (SIP) of a antifouling polymer brush on various classes of surfaces, including noble metals, metal oxides and inert polymers. Inspired by the versatility of mussel adhesive proteins, we synthesized a novel bifunctional tripeptide bromide (BrYKY) which combines an atom transfer radical polymerization (ATRP) initiating alkyl bromide with l-3,4-dihydroxyphenylalanine (DOPA) and lysine. Simple dip-coating of substrates with variable wetting properties and compositions, including Teflon®, in a BrYKY solution at pH 8.5 led to formation of a thin film of cross-linked BrYKY. Subsequently, we showed that the BrYKY layer initiated the ATRP of a zwitterionic monomer, sulfobetaine methacrylate (SBMA) on all substrates, resulting in high density antifouling pSBMA brushes. Both BrYKY deposition and pSBMA grafting were unambiguously confirmed by ellipsometry, X-ray photoelectron spectroscopy and goniometry. All substrates that were coated with BrYKY/pSBMA dramatically reduced bacterial adhesion for 24 h and also resisted mammalian cell adhesion for at least 4 months, demonstrating the long-term stability of the BrYKY anchoring and antifouling properties of pSBMA. The use of BrYKY as a primer and polymerization initiator has the potential to be widely employed in surface grafted polymer brush modifications for biomedical and other applications. PMID:22506651

  2. Dioxin Exposure Initiative Publications

    EPA Science Inventory

    Following is a listing of published articles that have come out of EPA's Dioxin Exposure Initiative

    SOURCES:

      <...

    1. City 2020+

      NASA Astrophysics Data System (ADS)

      Schneider, C.; Buttstädt, M.; Merbitz, H.; Sachsen, T.; Ketzler, G.; Michael, S.; Klemme, M.; Dott, W.; Selle, K.; Hofmeister, H.

      2010-09-01

      This research initiative CITY 2020+ assesses the risks and opportunities for residents in urban built environments under projected demographic and climate change for the year 2020 and beyond, using the City of Aachen as a case study. CITY 2020+ develops scenarios, options and tools for planning and developing sustainable future city structures. We investigate how urban environment, political structure and residential behavior can best be adapted, with attention to the interactions among structural, political, and sociological configurations and with their consequences on human health. Demographers project that in the EU-25-States by 2050, approximately 30% of the population will be over age 65. Also by 2050, average tem¬peratures are projected to rise by 1 to 2 K. Combined, Europe can expect enhanced thermal stress and higher levels of particulate matter. CITY 2020+ amongst other sub-projects includes research project dealing with (1) a micro-scale assessment of blockages to low-level cold-air drainage flow into the city centre by vegetation and building structures, (2) a detailed analysis of the change of probability density functions related to the occurrence of heat waves during summer and the spatial and temporal structure of the urban heat island (UHI) (3) a meso-scale analysis of particulate matter (PM) concentrations depending on topography, local meteorological conditions and synoptic-scale weather patterns. First results will be presented specifically from sub-projects related to vegetation barriers within cold air drainage, the assessment of the UHI and the temporal and spatial pattern of PM loadings in the city centre. The analysis of the cold air drainage flow is investigated in two consecutive years with a clearing of vegetation stands in the beginning of the second year early in 2010. The spatial pattern of the UHI and its possible enhancement by climate change is addressed employing a unique setup using GPS devices and temperature probes fixed to

    2. Status Report on the Illinois Articulation Initiative.

      ERIC Educational Resources Information Center

      Illinois Community Coll. Board, Springfield.

      The Illinois Articulation Initiative is a comprehensive statewide effort among colleges and universities to enhance the transfer process for students among all sectors of higher education in Illinois. One of the main features of the initiative is the general education core curriculum and a list of statewide articulated general education courses…

    3. 18 CFR 4.1 - Initial cost statement.

      Code of Federal Regulations, 2011 CFR

      2011-04-01

      ... OF PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.1 Initial cost statement. (a) Notification of Commission. When a project is constructed under a license issued under the... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Initial cost statement...

    4. 18 CFR 4.1 - Initial cost statement.

      Code of Federal Regulations, 2014 CFR

      2014-04-01

      ... OF PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.1 Initial cost statement. (a) Notification of Commission. When a project is constructed under a license issued under the... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Initial cost statement...

    5. 18 CFR 4.1 - Initial cost statement.

      Code of Federal Regulations, 2012 CFR

      2012-04-01

      ... OF PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.1 Initial cost statement. (a) Notification of Commission. When a project is constructed under a license issued under the... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Initial cost statement...

    6. 18 CFR 4.1 - Initial cost statement.

      Code of Federal Regulations, 2013 CFR

      2013-04-01

      ... OF PROJECT COSTS Determination of Cost of Projects Constructed Under License § 4.1 Initial cost statement. (a) Notification of Commission. When a project is constructed under a license issued under the... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Initial cost statement...

    7. 7 CFR 400.303 - Initial selection criteria.

      Code of Federal Regulations, 2010 CFR

      2010-01-01

      ... 7 Agriculture 6 2010-01-01 2010-01-01 false Initial selection criteria. 400.303 Section 400.303... Regulations for the 1991 and Succeeding Crop Years § 400.303 Initial selection criteria. (a) Nonstandard... .30 or greater; and (4) Either of the following apply: (i) The natural logarithm of the cumulative...

    8. Improving Initial Assessment in Work-Based Learning.

      ERIC Educational Resources Information Center

      Green, Muriel

      This document, which is designed to assist managers, trainers, or assessors in work-based provision across the United Kingdom, shares the experiences of five work-based learning providers that sought to improve their initial assessment processes. Section 1 explains the purpose of initial assessment and presents guidelines for evaluating intake…

    9. Initiation into Adolescent Marijuana Use.

      ERIC Educational Resources Information Center

      Brook, Judith S.; And Others

      1980-01-01

      This longitudinal study examined the relationship of three domains (personality/attitudinal orientations, peer relationships, and family socialization factors) with initiation into adolescent marihuana use. (Author/DB)

    10. Multipoint propagators for non-Gaussian initial conditions

      DOE Office of Scientific and Technical Information (OSTI.GOV)

      Bernardeau, Francis; Sefusatti, Emiliano; Crocce, Martin

      2010-10-15

      We show here how renormalized perturbation theory calculations applied to the quasilinear growth of the large-scale structure can be carried on in presence of primordial non-Gaussian (PNG) initial conditions. It is explicitly demonstrated that the series reordering scheme proposed in Bernardeau, Crocce, and Scoccimarro [Phys. Rev. D 78, 103521 (2008)] is preserved for non-Gaussian initial conditions. This scheme applies to the power spectrum and higher-order spectra and is based on a reorganization of the contributing terms into the sum of products of multipoint propagators. In case of PNG, new contributing terms appear, the importance of which is discussed in themore » context of current PNG models. The properties of the building blocks of such resummation schemes, the multipoint propagators, are then investigated. It is first remarked that their expressions are left unchanged at one-loop order irrespective of statistical properties of the initial field. We furthermore show that the high-momentum limit of each of these propagators can be explicitly computed even for arbitrary initial conditions. They are found to be damped by an exponential cutoff whose expression is directly related to the moment generating function of the one-dimensional displacement field. This extends what had been established for multipoint propagators for Gaussian initial conditions. Numerical forms of the cutoff are shown for the so-called local model of PNG.« less

    11. Exploding wires initiation of nitromethane sensitized by diethylenetriamine

      NASA Astrophysics Data System (ADS)

      Ushnurtsev, A. E.; Shilkin, N. S.; Utkin, A. V.; Mintsev, V. B.

      2018-01-01

      Experiments on initiation of nitromethane sensitized by diethylenetriamine in weight proportion 98/2 by exploding wires were conducted. Several conditions of initiation of low speed detonation were determined.

    12. 40 CFR 155.50 - Initiate a pesticide's registration review.

      Code of Federal Regulations, 2013 CFR

      2013-07-01

      ... 40 Protection of Environment 25 2013-07-01 2013-07-01 false Initiate a pesticide's registration...) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures § 155.50 Initiate a pesticide's registration review. The Agency will initiate a pesticide's registration review by...

    13. 40 CFR 155.50 - Initiate a pesticide's registration review.

      Code of Federal Regulations, 2014 CFR

      2014-07-01

      ... 40 Protection of Environment 24 2014-07-01 2014-07-01 false Initiate a pesticide's registration...) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures § 155.50 Initiate a pesticide's registration review. The Agency will initiate a pesticide's registration review by...

    14. 40 CFR 155.50 - Initiate a pesticide's registration review.

      Code of Federal Regulations, 2012 CFR

      2012-07-01

      ... 40 Protection of Environment 25 2012-07-01 2012-07-01 false Initiate a pesticide's registration...) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures § 155.50 Initiate a pesticide's registration review. The Agency will initiate a pesticide's registration review by...

    15. 40 CFR 155.50 - Initiate a pesticide's registration review.

      Code of Federal Regulations, 2011 CFR

      2011-07-01

      ... 40 Protection of Environment 24 2011-07-01 2011-07-01 false Initiate a pesticide's registration...) PESTICIDE PROGRAMS REGISTRATION STANDARDS AND REGISTRATION REVIEW Registration Review Procedures § 155.50 Initiate a pesticide's registration review. The Agency will initiate a pesticide's registration review by...

    16. 78 FR 67168 - Sixth Annual Sentinel Initiative; Public Workshop

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-11-08

      ...] Sixth Annual Sentinel Initiative; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION... workshop entitled ``Sixth Annual Sentinel Initiative.'' Convened by the Engelberg Center for Health Care... product surveillance. Topics will include an overview of the status of FDA's Sentinel Initiative and...

    17. 78 FR 31977 - NASA Asteroid Initiative Call for Ideas

      Federal Register 2010, 2011, 2012, 2013, 2014

      2013-05-28

      ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 13-060] NASA Asteroid Initiative Call for... agency's asteroid initiative planning and to encourage feedback and ideas from the global community and... Perspective--Tom Kalil 9:55-10:15 Asteroid Initiative--Associate Administrator Lightfoot [[Page 31978

    18. 20 CFR 418.3605 - What is an initial determination?

      Code of Federal Regulations, 2010 CFR

      2010-04-01

      ... Subsidies Determinations and the Administrative Review Process § 418.3605 What is an initial determination? Initial determinations are the determinations we make that are subject to administrative and judicial... conclusions. Examples of initial determinations that are subject to administrative and judicial review include...

  1. USASOC Injury Prevention/Performance Optimization Musculoskeletal Screening Initiative

    DTIC Science & Technology

    2016-10-29

    Initiative " PRINCIPAL INVESTIGATOR: Kim Beals RECIPIENT: Dr. Christie Vu REPORT DATE: October 2016 TYPE OF REPORT: Annual PREPARED FOR: U.S...Injury Prevention/Performance Optimization Musculoskeletal Screening Initiative 5a. CONTRACT NUMBER W81XWH-15-C-0179 " 5b. GRANT NUMBER 5c... initiate work on the Phase 3 and 4 research aims b) IRB & DoD Regulatory Approvals i) University of Pittsburgh IRB approved May 23, 2016 ii) HRPO USAMRMC

  2. Evolution of the magnetorotational instability on initially tangled magnetic fields

    NASA Astrophysics Data System (ADS)

    Bhat, Pallavi; Ebrahimi, Fatima; Blackman, Eric G.; Subramanian, Kandaswamy

    2017-12-01

    The initial magnetic field of previous magnetorotational instability (MRI) simulations has always included a significant system-scale component, even if stochastic. However, it is of conceptual and practical interest to assess whether the MRI can grow when the initial field is turbulent. The ubiquitous presence of turbulent or random flows in astrophysical plasmas generically leads to a small-scale dynamo (SSD), which would provide initial seed turbulent velocity and magnetic fields in the plasma that becomes an accretion disc. Can the MRI grow from these more realistic initial conditions? To address this, we supply a standard shearing box with isotropically forced SSD generated magnetic and velocity fields as initial conditions and remove the forcing. We find that if the initially supplied fields are too weak or too incoherent, they decay from the initial turbulent cascade faster than they can grow via the MRI. When the initially supplied fields are sufficient to allow MRI growth and sustenance, the saturated stresses, large-scale fields and power spectra match those of the standard zero net flux MRI simulation with an initial large-scale vertical field.

  3. 38 CFR 20.1500 - Rule 1500. Expedited Claims Adjudication Initiative.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Claims Adjudication Initiative. 20.1500 Section 20.1500 Pensions, Bonuses, and Veterans' Relief... Adjudication Initiative-Pilot Program § 20.1500 Rule 1500. Expedited Claims Adjudication Initiative. (a) Purpose. The Expedited Claims Adjudication Initiative is a pilot program designed to streamline the claims...

  4. Should tsunami simulations include a nonzero initial horizontal velocity?

    NASA Astrophysics Data System (ADS)

    Lotto, Gabriel C.; Nava, Gabriel; Dunham, Eric M.

    2017-08-01

    Tsunami propagation in the open ocean is most commonly modeled by solving the shallow water wave equations. These equations require initial conditions on sea surface height and depth-averaged horizontal particle velocity or, equivalently, horizontal momentum. While most modelers assume that initial velocity is zero, Y.T. Song and collaborators have argued for nonzero initial velocity, claiming that horizontal displacement of a sloping seafloor imparts significant horizontal momentum to the ocean. They show examples in which this effect increases the resulting tsunami height by a factor of two or more relative to models in which initial velocity is zero. We test this claim with a "full-physics" integrated dynamic rupture and tsunami model that couples the elastic response of the Earth to the linearized acoustic-gravitational response of a compressible ocean with gravity; the model self-consistently accounts for seismic waves in the solid Earth, acoustic waves in the ocean, and tsunamis (with dispersion at short wavelengths). Full-physics simulations of subduction zone megathrust ruptures and tsunamis in geometries with a sloping seafloor confirm that substantial horizontal momentum is imparted to the ocean. However, almost all of that initial momentum is carried away by ocean acoustic waves, with negligible momentum imparted to the tsunami. We also compare tsunami propagation in each simulation to that predicted by an equivalent shallow water wave simulation with varying assumptions regarding initial velocity. We find that the initial horizontal velocity conditions proposed by Song and collaborators consistently overestimate the tsunami amplitude and predict an inconsistent wave profile. Finally, we determine tsunami initial conditions that are rigorously consistent with our full-physics simulations by isolating the tsunami waves from ocean acoustic and seismic waves at some final time, and backpropagating the tsunami waves to their initial state by solving the

  5. Introducing Research Initiatives into Healthcare: What Do Doctors Think?

    PubMed Central

    Wyld, Lucy; Smith, Sian; Hawkins, Nicholas J.; Long, Janet

    2014-01-01

    Background: Current national and international policies emphasize the need to develop research initiatives within our health care system. Institutional biobanking represents a modern, large-scale research initiative that is reliant upon the support of several aspects of the health care organization. This research project aims to explore doctors' views on the concept of institutional biobanking and to gain insight into the factors which impact the development of research initiatives within healthcare systems. Methods: Qualitative research study using semi-structured interviews. The research was conducted across two public teaching hospitals in Sydney, Australia where institutional biobanking was being introduced. Twenty-five participants were interviewed, of whom 21 were medical practitioners at the specialist trainee level or above in a specialty directly related to biobanking; four were key stakeholders responsible for the design and implementation of the biobanking initiative. Results: All participants strongly supported the concept of institutional biobanking. Participants highlighted the discordance between the doctors who work to establish the biobank (the contributors) and the researchers who use it (the consumers). Participants identified several barriers that limit the success of research initiatives in the hospital setting including: the ‘resistance to change’ culture; the difficulties in engaging health professionals in research initiatives; and the lack of incentives offered to doctors for their contribution. Doctors positively valued the opportunity to advise the implementation team, and felt that the initiative could benefit from their knowledge and expertise. Conclusion: Successful integration of research initiatives into hospitals requires early collaboration between the implementing team and the health care professionals to produce a plan that is sensitive to the needs of the health professionals and tailored to the hospital setting. Research

  6. Career Technical Education Pathways Initiative Annual Report

    ERIC Educational Resources Information Center

    California Community Colleges, Chancellor's Office, 2014

    2014-01-01

    California's education system--the largest in the United States--is an essential resource for ensuring strong economic growth in the state. The Career Technical Education Pathways Initiative (the Initiative) became law in 2005 with Senate Bills 70 and 1133 and provided more than $380 million over eight years to improve career technical education…

  7. 10 CFR 780.20 - Initiation of proceeding.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Initiation of proceeding. 780.20 Section 780.20 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS Declaring Patents Affected With the Public Interest Under Section 153a of the Atomic Energy Act of 1954 § 780.20 Initiation of proceeding. When any...

  8. 10 CFR 780.20 - Initiation of proceeding.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Initiation of proceeding. 780.20 Section 780.20 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS Declaring Patents Affected With the Public Interest Under Section 153a of the Atomic Energy Act of 1954 § 780.20 Initiation of proceeding. When any...

  9. 10 CFR 780.20 - Initiation of proceeding.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Initiation of proceeding. 780.20 Section 780.20 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS Declaring Patents Affected With the Public Interest Under Section 153a of the Atomic Energy Act of 1954 § 780.20 Initiation of proceeding. When any...

  10. 10 CFR 780.20 - Initiation of proceeding.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Initiation of proceeding. 780.20 Section 780.20 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS Declaring Patents Affected With the Public Interest Under Section 153a of the Atomic Energy Act of 1954 § 780.20 Initiation of proceeding. When any...

  11. 10 CFR 780.20 - Initiation of proceeding.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Initiation of proceeding. 780.20 Section 780.20 Energy DEPARTMENT OF ENERGY PATENT COMPENSATION BOARD REGULATIONS Declaring Patents Affected With the Public Interest Under Section 153a of the Atomic Energy Act of 1954 § 780.20 Initiation of proceeding. When any...

  12. 14 CFR 77.33 - Initiation of studies.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Initiation of studies. 77.33 Section 77.33... OBJECTS AFFECTING NAVIGABLE AIRSPACE (Eff. until 1-18-11) Aeronautical Studies of Effect of Proposed Construction on Navigable Airspace § 77.33 Initiation of studies. (a) An aeronautical study is conducted by the...

  13. 14 CFR 77.33 - Initiation of studies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Initiation of studies. 77.33 Section 77.33... OBJECTS AFFECTING NAVIGABLE AIRSPACE Aeronautical Studies of Effect of Proposed Construction on Navigable Airspace § 77.33 Initiation of studies. (a) An aeronautical study is conducted by the FAA: (1) Upon the...

  14. The Plus 50 Initiative: Standards of Excellence

    ERIC Educational Resources Information Center

    American Association of Community Colleges (NJ1), 2010

    2010-01-01

    The American Association of Community Colleges' (AACC) Plus 50 Initiative (2008-2011), funded by The Atlantic Philanthropies, was created to build the capacity of community colleges nationwide to develop programming that engages the plus 50 learner. The Initiative supported a pilot group of 13 two-year institutions to develop or expand college…

  15. Network support for system initiated checkpoints

    DOEpatents

    Chen, Dong; Heidelberger, Philip

    2013-01-29

    A system, method and computer program product for supporting system initiated checkpoints in parallel computing systems. The system and method generates selective control signals to perform checkpointing of system related data in presence of messaging activity associated with a user application running at the node. The checkpointing is initiated by the system such that checkpoint data of a plurality of network nodes may be obtained even in the presence of user applications running on highly parallel computers that include ongoing user messaging activity.

  16. Initiation reactions in acetylene pyrolysis

    DOE PAGES

    Zador, Judit; Fellows, Madison D.; Miller, James A.

    2017-05-10

    In gas-phase combustion systems the interest in acetylene stems largely from its role in molecular weight growth processes. The consensus is that above 1500 K acetylene pyrolysis starts mainly with the homolytic fission of the C–H bond creating an ethynyl radical and an H atom. However, below ~1500 K this reaction is too slow to initiate the chain reaction. It has been hypothesized that instead of dissociation, self-reaction initiates this process. Nevertheless, rigorous theoretical or direct experimental evidence is lacking, to an extent that even the molecular mechanism is debated in the literature. In this work we use rigorous abmore » initio transition-state theory master equation methods to calculate pressure- and temperature-dependent rate coefficients for the association of two acetylene molecules and related reactions. We establish the role of vinylidene, the high-energy isomer of acetylene in this process, compare our results with available experimental data, and assess the competition between the first-order and second-order initiation steps. As a result, we also show the effect of the rapid isomerization among the participating wells and highlight the need for time-scale analysis when phenomenological rate coefficients are compared to observed time scales in certain experiments.« less

  17. Driver-initiated distractions: examining strategic adaptation for in-vehicle task initiation.

    PubMed

    Horrey, William J; Lesch, Mary F

    2009-01-01

    Today, drivers are faced with many in-vehicle activities that are potentially distracting. In many cases, they are not passive recipients of these tasks; rather, drivers decide whether or not (or how) to perform them. In this study, we examined whether drivers, given knowledge of the upcoming road demands, would strategically delay performing in-vehicle activities until demands were reduced. Twenty drivers drove an instrumented van around a closed track that was divided into sections of varying demands and difficulty. Drivers were asked to perform one of four in-vehicle tasks (e.g., phone conversation; read a text message; find an address; pick up an object on the floor); however, they were free to decide when to initiate these tasks, provided they finish them before a given deadline. Although drivers were fully aware of the relative demands of the road, they did not tend to strategically postpone tasks--a finding that was consistent across the different tasks (p >.05). Rather, drivers tended to initiate tasks regardless of the current driving conditions. This strategy frequently led to driving errors. Given the control that drivers have over many in-vehicle distractions, interventions that focus on strategic decisions and planning may have merit.

  18. Best Practices & Outstanding Initiatives

    ERIC Educational Resources Information Center

    Training, 2011

    2011-01-01

    In this article, "Training" editors recognize innovative and successful learning and development programs and practices. They share best practices from Automatic Data Processing, Inc., Farmers Insurance Group, FedEx Express, InterContinental Hotels Group, and Oakwood Temporary Housing. They also present the outstanding initiatives of EMD Serono,…

  19. Monolithic exploding foil initiator

    DOEpatents

    Welle, Eric J; Vianco, Paul T; Headley, Paul S; Jarrell, Jason A; Garrity, J. Emmett; Shelton, Keegan P; Marley, Stephen K

    2012-10-23

    A monolithic exploding foil initiator (EFI) or slapper detonator and the method for making the monolithic EFI wherein the exploding bridge and the dielectric from which the flyer will be generated are integrated directly onto the header. In some embodiments, the barrel is directly integrated directly onto the header.

  20. 78 FR 51750 - NASA Asteroid Initiative Idea Synthesis Workshop

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-21

    ... NATIONAL AERONAUTICS AND SPACE ADMINISTRATION [Notice: 13-096] NASA Asteroid Initiative Idea... Conference to examine ideas in response to the recent RFI for the agency's Asteroid Initiative. SUMMARY: The... Agency's Asteroid Initiative planning and to enable feedback and discussion from the global community and...

  1. 75 FR 76018 - Third Annual Sentinel Initiative Public Workshop

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ...] Third Annual Sentinel Initiative Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION... workshop: Third Annual Sentinel Initiative Public Workshop. Hosted by the Engelberg Center for Health Care..., including an update on Mini-Sentinel and related activities, near-term plans for FDA's Sentinel Initiative...

  2. Structuring Cooperative Nuclear RIsk Reduction Initiatives with China.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Brandt, Larry; Reinhardt, Jason Christian; Hecker, Siegfried

    The Stanford Center for International Security and Cooperation engaged several Chinese nuclear organizations in cooperative research that focused on responses to radiological and nuclear terrorism. The objective was to identify joint research initiatives to reduce the global dangers of such threats and to pursue initial technical collaborations in several high priority areas. Initiatives were identified in three primary research areas: 1) detection and interdiction of smuggled nuclear materials; 2) nuclear forensics; and 3) radiological (“dirty bomb”) threats and countermeasures. Initial work emphasized the application of systems and risk analysis tools, which proved effective in structuring the collaborations. The extensive engagementsmore » between national security nuclear experts in China and the U.S. during the research strengthened professional relationships between these important communities.« less

  3. 12 CFR 508.6 - Initiation of hearing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Initiation of hearing. 508.6 Section 508.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.6 Initiation of hearing. (a) Within 10 days of the filing...

  4. The Campus Diversity Initiative: A Case Study

    ERIC Educational Resources Information Center

    Nayak, Sharada

    2005-01-01

    This Case Study presents the Campus Diversity Initiative (CDI), a three-phase project lead by the Educational Resources Project Centre Trust, in New Delhi, India. In a historic and cultural context different from that of India, the American Diversity Initiative was launched by the Ford Foundation in 1990 and addressed their diversity issues by…

  5. 15 CFR 1160.22 - Goal of the Strategic Partnership initiative.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... initiative. 1160.22 Section 1160.22 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign... INNOVATION Strategic Partnership Initiative § 1160.22 Goal of the Strategic Partnership initiative. (a) This new initiative is designed to provide the private sector with the opportunity to discuss the possible...

  6. 38 CFR 20.1510 - Rule 1510. Termination of the Initiative.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the Initiative. 20.1510 Section 20.1510 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) BOARD OF VETERANS' APPEALS: RULES OF PRACTICE Expedited Claims Adjudication Initiative-Pilot Program § 20.1510 Rule 1510. Termination of the Initiative. VA may terminate the Initiative at any...

  7. Control of Initialized Fractional-Order Systems. Revised

    NASA Technical Reports Server (NTRS)

    Hartley, Tom T.; Lorenzo, Carl F.

    2002-01-01

    Due to the importance of historical effects in fractional-order systems, this paper presents a general fractional-order control theory that includes the time-varying initialization response. Previous studies have not properly accounted for these historical effects. The initialization response, along with the forced response, for fractional-order systems is determined. Stability properties of fractional-order systems are presented in the complex w-plane, which is a transformation of the s-plane. Time responses are discussed with respect to pole positions in the complex w-plane and frequency response behavior is included. A fractional-order vector space representation, which is a generalization of the state space concept, is presented including the initialization response. Control methods for vector representations of initialized fractional-order systems are shown. Nyquist, root-locus, and other input-output control methods are adapted to the control of fractional-order systems. Finally, the fractional-order differintegral is generalized to continuous order-distributions that have the possibility of including a continuum of fractional orders in a system element.

  8. [Initial diagnosis of Parkinson's disease - neuroradiological diagnosis].

    PubMed

    Orimo, Satoshi

    2013-01-01

    Brain MRI is essential for differentiating Parkinson's disease (PD) from other parkinsonian syndromes. The purpose of performing brain MRI is not to make a diagnosis of PD but is to exclude other parkinsonian syndromes. Recently, several new MRI techniques such as voxel based morphometry, relaxometry, magnetization transfer, spectroscopy, tractography, and functional MRI have been introduced in the diagnosis of PD. Neuromelanin imaging is one of the new techniques and can be useful to make an initial diagnosis of PD. MIBG myocardial scintigraphy is a sensitive imaging tool to differentiate PD from other parkinsonian syndromes and is one of the good tools to make an initial diagnosis of PD. Brain perfusion imaging is sometimes useful to make an initial diagnosis of PD, because reduced brain perfusion area can be detected before brain MRI detects morphological changes of the brain. Dopamine transporter imaging, not available in Japan, is a sensitive tool to detect very early parkinsonism and is useful to make an initial diagnosis of PD. However, it is difficult to differentiate PD from other parkinsonian syndromes.

  9. United Nations Human Space Technology Initiative (HSTI)

    NASA Astrophysics Data System (ADS)

    Ochiai, Mika; Niu, Aimin; Steffens, Heike; Balogh, Werner; Haubold, Hans; Othman, Mazlan; Doi, Takao

    2014-11-01

    The Human Space Technology Initiative was launched in 2010 within the framework of the United Nations Programme on Space Applications implemented by the Office for Outer Space Affairs of the United Nations. It aims to involve more countries in activities related to human spaceflight and space exploration and to increase the benefits from the outcome of such activities through international cooperation, to make space exploration a truly international effort. The role of the Initiative in these efforts is to provide a platform to exchange information, foster collaboration between partners from spacefaring and non-spacefaring countries, and encourage emerging and developing countries to take part in space research and benefit from space applications. The Initiative organizes expert meetings and workshops annually to raise awareness of the current status of space exploration activities as well as of the benefits of utilizing human space technology and its applications. The Initiative is also carrying out primary science activities including the Zero-Gravity Instrument Project and the Drop Tower Experiment Series aimed at promoting capacity-building activities in microgravity science and education, particularly in developing countries.

  10. 10 CFR 55.33 - Disposition of an initial application.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Disposition of an initial application. 55.33 Section 55.33 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) OPERATORS' LICENSES Applications § 55.33 Disposition of an initial application. (a) Requirements for the approval of an initial application. The Commission...

  11. Microenergetic Shock Initiation Studies on Deposited Films of Petn

    NASA Astrophysics Data System (ADS)

    Tappan, Alexander S.; Wixom, Ryan R.; Trott, Wayne M.; Long, Gregory T.; Knepper, Robert; Brundage, Aaron L.; Jones, David A.

    2009-12-01

    Films of the high explosive PETN (pentaerythritol tetranitrate) up to 500-μm thick have been deposited through physical vapor deposition, with the intent of creating well-defined samples for shock-initiation studies. PETN films were characterized with microscopy, x-ray diffraction, and focused ion beam nanotomography. These high-density films were subjected to strong shocks in both the out-of-plane and in-plane orientations. Initiation behavior was monitored with high-speed framing and streak camera photography. Direct initiation with a donor explosive (either RDX with binder, or CL-20 with binder) was possible in both orientations, but with the addition of a thin aluminum buffer plate (in-plane configuration only), initiation proved to be difficult. Initiation was possible with an explosively-driven 0.13-mm thick Kapton flyer and direct observation of initiation behavior was examined using streak camera photography at different flyer velocities. Models of this configuration were created using the shock physics code CTH.

  12. Initialization Method for Grammar-Guided Genetic Programming

    NASA Astrophysics Data System (ADS)

    García-Arnau, M.; Manrique, D.; Ríos, J.; Rodríguez-Patón, A.

    This paper proposes a new tree-generation algorithm for grammarguided genetic programming that includes a parameter to control the maximum size of the trees to be generated. An important feature of this algorithm is that the initial populations generated are adequately distributed in terms of tree size and distribution within the search space. Consequently, genetic programming systems starting from the initial populations generated by the proposed method have a higher convergence speed. Two different problems have been chosen to carry out the experiments: a laboratory test involving searching for arithmetical equalities and the real-world task of breast cancer prognosis. In both problems, comparisons have been made to another five important initialization methods.

  13. Initial singularity and pure geometric field theories

    NASA Astrophysics Data System (ADS)

    Wanas, M. I.; Kamal, Mona M.; Dabash, Tahia F.

    2018-01-01

    In the present article we use a modified version of the geodesic equation, together with a modified version of the Raychaudhuri equation, to study initial singularities. These modified equations are used to account for the effect of the spin-torsion interaction on the existence of initial singularities in cosmological models. Such models are the results of solutions of the field equations of a class of field theories termed pure geometric. The geometric structure used in this study is an absolute parallelism structure satisfying the cosmological principle. It is shown that the existence of initial singularities is subject to some mathematical (geometric) conditions. The scheme suggested for this study can be easily generalized.

  14. Laser diode initiated detonators for space applications

    NASA Technical Reports Server (NTRS)

    Ewick, David W.; Graham, J. A.; Hawley, J. D.

    1993-01-01

    Ensign Bickford Aerospace Company (EBAC) has over ten years of experience in the design and development of laser ordnance systems. Recent efforts have focused on the development of laser diode ordnance systems for space applications. Because the laser initiated detonators contain only insensitive secondary explosives, a high degree of system safety is achieved. Typical performance characteristics of a laser diode initiated detonator are described in this paper, including all-fire level, function time, and output. A finite difference model used at EBAC to predict detonator performance, is described and calculated results are compared to experimental data. Finally, the use of statistically designed experiments to evaluate performance of laser initiated detonators is discussed.

  15. ‘Crisis’ and ‘Everyday’ Initiators: A Qualitative Study of Coercion and Agency in the Context of Methadone Maintenance Treatment Initiation

    PubMed Central

    Damon, Will; Small, Will; Anderson, Solanna; Maher, Lisa; Wood, Evan; Kerr, Thomas; McNeil, Ryan

    2016-01-01

    Introduction and Aims Patient attrition is common among people enrolled in methadone maintenance treatment (MMT) programs and most pronounced during the first year of treatment. However, the experiences of patients initiating MMT have been overlooked in the literature. This study explores experiences of MMT initiation among MMT patients, focusing on contextual influences on MMT initiation and perceptions of MMT and their subsequent influence on treatment retention. Design and Methods Semi-structured qualitative interviews were conducted with 39 MMT patients in Vancouver, Canada. Individuals reporting enrolment in MMT were recruited from within two ongoing cohort studies comprised of people who use drugs. Interview transcripts were analysed using an inductive and iterative approach. Results Two groups of MMT initiators were identified: (i) ‘crisis initiators’ prescribed methadone following critical transition events, such as incarceration or pregnancy; and (ii) ‘everyday initiators’ enrolled in MMT as part of routine healthcare utilisation. While most ‘crisis initiators’ and some ‘everyday initiators’ described experiencing coercion during MMT initiation, ‘crisis initiators’ were further subjected to the coercive leveraging of their vulnerability to motivate ‘consent’ for MMT. ‘Crisis initiators’ developed negative views towards MMT and were more likely to discontinue treatment. Long-standing patient– provider relationships and open dialogue were associated with more positive views regarding MMT, regardless of the circumstances of initiation. Discussion and Conclusion Findings underscore the need for clear and effective communication regarding treatment regimens and expectations during MMT initiation. Furthermore, training in trauma-informed care may help reduce perceptions of coercion and rates of early treatment termination. PMID:27126765

  16. A Track Initiation Method for the Underwater Target Tracking Environment

    NASA Astrophysics Data System (ADS)

    Li, Dong-dong; Lin, Yang; Zhang, Yao

    2018-04-01

    A novel efficient track initiation method is proposed for the harsh underwater target tracking environment (heavy clutter and large measurement errors): track splitting, evaluating, pruning and merging method (TSEPM). Track initiation demands that the method should determine the existence and initial state of a target quickly and correctly. Heavy clutter and large measurement errors certainly pose additional difficulties and challenges, which deteriorate and complicate the track initiation in the harsh underwater target tracking environment. There are three primary shortcomings for the current track initiation methods to initialize a target: (a) they cannot eliminate the turbulences of clutter effectively; (b) there may be a high false alarm probability and low detection probability of a track; (c) they cannot estimate the initial state for a new confirmed track correctly. Based on the multiple hypotheses tracking principle and modified logic-based track initiation method, in order to increase the detection probability of a track, track splitting creates a large number of tracks which include the true track originated from the target. And in order to decrease the false alarm probability, based on the evaluation mechanism, track pruning and track merging are proposed to reduce the false tracks. TSEPM method can deal with the track initiation problems derived from heavy clutter and large measurement errors, determine the target's existence and estimate its initial state with the least squares method. What's more, our method is fully automatic and does not require any kind manual input for initializing and tuning any parameter. Simulation results indicate that our new method improves significantly the performance of the track initiation in the harsh underwater target tracking environment.

  17. Self-Initiated Art Work and School Art

    ERIC Educational Resources Information Center

    Haanstra, Folkert

    2010-01-01

    This article deals with the forms and contents of self-initiated art works: the kind of learning that takes place in the production of self-initiated art works as well as the relationships with school art. We interviewed 52 Dutch students (aged between 10 and 14) from different schools of primary and secondary education, and their art teachers.…

  18. 14 CFR 302.310 - Exemptions on the Department's initiative.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Exemptions on the Department's initiative... and Certain Other Proceedings § 302.310 Exemptions on the Department's initiative. The Department may grant exemptions on its own initiative when it finds that such exemptions are required by the...

  19. 49 CFR 593.8 - Determinations on the agency's initiative.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Determinations on the agency's initiative. 593.8... § 593.8 Determinations on the agency's initiative. (a) The Administrator may make a determination of eligibility on his or her own initiative. The agency publishes in the Federal Register, affording opportunity...

  20. Macro-level age norms for the timing of sexual initiation and adolescents' early sexual initiation in 17 European countries.

    PubMed

    Madkour, Aubrey Spriggs; de Looze, Margaretha; Ma, Ping; Halpern, Carolyn Tucker; Farhat, Tilda; Ter Bogt, Tom F M; Ehlinger, Virginie; Nic Gabhainn, Saoirse; Currie, Candace; Godeau, Emmanuelle

    2014-07-01

    To examine the relationship between country-level age norms for sexual initiation timing and early sexual initiation (ESI) among adolescent boys and girls. Nationally representative data from 17 countries that participated in the 2006/2007 European Social Survey (ESS-3, n = 33,092) and the 2005/2006 Health Behaviour in School-Aged Children Study (HBSC, n = 27,702) were analyzed. Age norms were measured as the average country-level response to an item asking the age at which ESS respondents believed someone is too young to have sexual intercourse. HBSC respondents (aged 14-16 years) self-reported age at sexual initiation, which we defined as early (<15 years) or not early (≥15 years or no initiation). Control variables included age, family affluence, perceived socioeconomic status, family living arrangement, substance use, school attachment, and country-level legal age of consent. Multivariable three-level logistic models with random intercepts were run separately by sex. In multivariable analyses, higher overall age norms were associated with reduced likelihood of ESI among girls (AOR .60, 95% CI .45-.79); associations with ESI were stronger for parent cohort (ages 31-65 years) norms (AOR .37, 95% CI .23-.58) than for peer cohort (ages 15-20 years) norms (AOR .60, 95% CI .49-.74). For boys, overall norms were also significantly negatively associated with ESI (AOR .68, 95% CI .46-.99), as were parent cohort norms (AOR .66, 95% CI .45-.96). Peer cohort norms were not significantly related to boys' ESI. Macrolevel cultural norms may impact adolescents' sexual initiation timing. Research exploring the sexual health outcomes of early initiators in countries with contrasting age norms is warranted. Copyright © 2014 Society for Adolescent Health and Medicine. All rights reserved.

  1. Macro-level Age Norms for the Timing of Sexual Initiation and Adolescents’ Early Sexual Initiation in 17 European Countries

    PubMed Central

    Madkour, Aubrey Spriggs; de Looze, Margaretha; Ma, Ping; Halpern, Carolyn Tucker; Farhat, Tilda; ter Bogt, Tom F. M.; Ehlinger, Virginie; Nic Gabhainn, Saoirse; Currie, Candace; Godeau, Emmanuelle

    2014-01-01

    Purpose To examine the relationship between country-level age norms for sexual initiation timing and early sexual initiation (ESI) among adolescent boys and girls. Methods Nationally-representative data from 17 countries that participated in the 2006/07 European Social Survey (ESS-3, n=33,092) and the 2005/06 Health Behaviour in School-Aged Children Study (HBSC, n=27,702) were analyzed. Age norms were measured as the average country-level response to an item asking the age at which ESS respondents believed someone is too young to have sexual intercourse. HBSC respondents (aged 14-16) self-reported age at sexual initiation which we defined as early (<15 years) or not (≥15 years or no initiation). Control variables included age, family affluence, perceived socioeconomic status, family living arrangement, substance use, school attachment, and country-level legal age of consent. Multivariable three-level logistic models with random intercepts were run separately by sex. Results In multivariable analyses, higher overall age norms were associated with reduced likelihood of ESI among girls (AOR 0.60, 95% CI 0.45-0.79); associations with ESI were stronger for parent cohort (ages 31-65) norms (AOR 0.37, 95% CI 0.23-0.58) than for peer cohort (ages 15-20) norms (AOR 0.60, 95% CI 0.49-0.74). For boys, overall norms were also significantly negatively associated with ESI (AOR 0.68, 95% CI 0.46-0.99), as were parent cohort norms (AOR 0.66, 95% CI 0.45-0.96). Peer cohort norms were not significantly related to boys’ ESI. Conclusion Macro-level cultural norms may impact adolescents’ sexual initiation timing. Research exploring the sexual health outcomes of early initiators in countries with contrasting age norms is warranted. PMID:24508092

  2. Genome-wide uniformity of human ‘open’ pre-initiation complexes

    PubMed Central

    Lai, William K.M.; Pugh, B. Franklin

    2017-01-01

    Transcription of protein-coding and noncoding DNA occurs pervasively throughout the mammalian genome. Their sites of initiation are generally inferred from transcript 5′ ends and are thought to be either locally dispersed or focused. How these two modes of initiation relate is unclear. Here, we apply permanganate treatment and chromatin immunoprecipitation (PIP-seq) of initiation factors to identify the precise location of melted DNA separately associated with the preinitiation complex (PIC) and the adjacent paused complex (PC). This approach revealed the two known modes of transcription initiation. However, in contrast to prevailing views, they co-occurred within the same promoter region: initiation originating from a focused PIC, and broad nucleosome-linked initiation. PIP-seq allowed transcriptional orientation of Pol II to be determined, which may be useful near promoters where sufficient sense/anti-sense transcript mapping information is lacking. PIP-seq detected divergently oriented Pol II at both coding and noncoding promoters, as well as at enhancers. Their occupancy levels were not necessarily coupled in the two orientations. DNA sequence and shape analysis of initiation complex sites suggest that both sequence and shape contribute to specificity, but in a context-restricted manner. That is, initiation sites have the locally “best” initiator (INR) sequence and/or shape. These findings reveal a common core to pervasive Pol II initiation throughout the human genome. PMID:27927716

  3. Direct measurement of initial wake separation (bo) and initial circulation (ro) using pulsed lidars

    DOT National Transportation Integrated Search

    2013-06-17

    The initial separation distance (bo) between a counter-rotating vortex pair generated by an aircraft is a fundamental parameter affecting wake turbulence decay. For the past decade Pulsed Doppler Lidars have emerged as the primary remote sensors for ...

  4. 40 CFR 2.204 - Initial action by EPA office.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Initial action by EPA office. 2.204... Confidentiality of Business Information § 2.204 Initial action by EPA office. (a) Situations requiring action. This section prescribes procedures to be used by EPA offices in making initial determinations of...

  5. Peters' Concept of "Education as Initiation": Communitarian or Individualist?

    ERIC Educational Resources Information Center

    Cotter, Richard

    2013-01-01

    A central element of Richard Peters' philosophy of education has been his analysis of "education as initiation". Understanding initiation is internally related to concepts of community and what it may mean to be a member. The concept of initiation assumes a mutually interdependent, dynamic relationship between the individual and community that…

  6. Idaho Math Initiative. Public School Information. Legislative Report, 2008

    ERIC Educational Resources Information Center

    Idaho State Department of Education, 2008

    2008-01-01

    The Idaho Math Initiative has been developed to help raise student achievement in mathematics across all K-12 grades, focusing on three main areas: teacher education, student achievement, and public awareness. This report describes the initial phase of the Math Initiative, including: (1) Assessment; (2) Intervention; (3) Standards; (4) Curriculum;…

  7. Envisioning Effective Laptop Initiatives

    ERIC Educational Resources Information Center

    Clausen, Jon M.; Britten, Jody; Ring, Gail

    2008-01-01

    A recent survey of 74 building-level school administrators in Indiana challenged many of the assumptions regarding 1:1 laptop initiatives and how 1:1 access would affect teaching and learning. It also revealed disturbing realities regarding instructional practices of teachers, as well as efforts to improve school technology integration. The intent…

  8. Do initial conditions matter? A comparison of model climatologies generated from different initial states

    NASA Technical Reports Server (NTRS)

    Spar, J.; Cohen, C.; Wu, P.

    1981-01-01

    A coarse mesh (8 by 10) 7 layer global climate model was used to compute 15 months of meteorological history in two perpetual January experiments on a water planet (without continents) with a zonally symmetric climatological January sea surface temperature field. In the first of the two water planet experiments the initial atmospheric state was a set of zonal mean values of specific humidity, temperature, and wind at each latitude. In the second experiment the model was initialized with globally uniform mean values of specific humidity and temperature on each sigma level surface, constant surface pressure (1010 mb), and zero wind everywhere. A comparison was made of the mean January climatic states generated by the two water planet experiments. The first two months of each 15 January run were discarded, and 13 month averages were computed from months 3 through 15.

  9. National Intelligent Transportation Infrastructure Initiative

    DOT National Transportation Integrated Search

    1997-09-19

    This report gives an overview of the National Intelligent Transportation Infrastructure Initiative (NITI). NITI refers to the integrated electronics, communications, and hardware and software elements that are available to support Intelligent Transpo...

  10. Smart roadside initiative : user manual.

    DOT National Transportation Integrated Search

    2015-09-01

    This document provides the user instructions for the Smart Roadside Initiative (SRI) applications including mobile and web-based SRI applications. These applications include smartphone-enabled information exchange and notification, and software compo...

  11. Initiation-promotion skin carcinogenesis and immunological competence.

    PubMed

    Curtis, G L; Stenbäck, F; Ryan, W L

    1975-10-01

    The immune competence of mice during initiation-promotion skin carcinogenesis was determined by skin allograft rejection and lymphocyte mitogenesis. The carcinogen 7, 12-dimethylbenzanthracene inhibited the cellular immune competence of mice while lymphocytes from croton oil treated mice had enhanced PWM response. Chlorphenesin, a stimulator of cellular immunity, was found to inhibit tumorigenesis in initiation-promotion skin carcinogenesis when injected during promotion.

  12. Replication initiator protein RepE of mini-F plasmid: functional differentiation between monomers (initiator) and dimers (autogenous repressor).

    PubMed Central

    Ishiai, M; Wada, C; Kawasaki, Y; Yura, T

    1994-01-01

    Replication of mini-F plasmid requires the plasmid-encoded RepE initiator protein and several host factors including DnaJ, DnaK, and GrpE, heat shock proteins of Escherichia coli. The RepE protein plays a crucial role in replication and exhibits two major functions: initiation of replication from the origin, ori2, and autogenous repression of repE transcription. One of the mini-F plasmid mutants that can replicate in the dnaJ-defective host produces an altered RepE (RepE54) with a markedly enhanced initiator activity but little or no repressor activity. RepE54 has been purified from cell extracts primarily in monomeric form, unlike the wild-type RepE that is recovered in dimeric form. Gel-retardation assays revealed that RepE54 monomers bind to ori2 (direct repeats) with a very high efficiency but hardly bind to the repE operator (inverted repeat), in accordance with the properties of RepE54 in vivo. Furthermore, the treatment of wild-type RepE dimers with protein denaturants enhanced their binding to ori2 but reduced binding to the operator: RepE dimers were partially converted to monomers, and the ori2 binding activity was uniquely associated with monomers. These results strongly suggest that RepE monomers represent an active form by binding to ori2 to initiate replication, whereas dimers act as an autogenous repressor by binding to the operator. We propose that RepE is structurally and functionally differentiated and that monomerization of RepE dimers, presumably mediated by heat shock protein(s), activates the initiator function and participates in regulation of mini-F DNA replication. Images PMID:8170998

  13. Black Carbon Diesel Initiative in the Russian Arctic

    EPA Pesticide Factsheets

    Mobile and stationary diesel engines are among the largest sources of black carbon emissions in the Arctic. To address this challenge, EPA is leading the Black Carbon Diesel Initiative under the Arctic Black Carbon Initiative (ABCI).

  14. Initial blood storage experiment

    NASA Technical Reports Server (NTRS)

    Surgenor, Douglas MACN.

    1988-01-01

    The design of the Initial Blood Storage Experiment (IBSE) was based upon a carefully controlled comparison between identical sets of human blood cell suspensions - red cells, white cell, and platelets - one set of which was transported aboard the Columbia on a 6 day 11 hour mission, and the other held on the ground. Both sets were carried inside stainless steel dewars within specially fabricated flight hardware. Individual bags of cell suspensions were randomly assigned with respect to ground vs orbit status, dewar chamber, and specific location within the dewar. To foster optimal preservation, each cell type was held under specific optimal conditions of pH, ionic strength, solute concentration, gas tension, and temperature. An added variable in this initial experiment was provided by the use of three different polymer/plasticizer formulations for the sealed bags which held the blood cells. At termination of the experiment, aliquots of the suspensions, identified only by code, were distributed to be assayed. Assays were selected to constitute a broad survey of cellular properties and thereby maximize the chances of detection of gravitational effects. A total of 74 different outcome measurements were reported for statistical analysis. When the measurements were completed, the results were entered into the IBSE data base, at which time the data were matched with the original blood bag numbers to determine their status with respect to polymer/plasticizer type, orbit status (orbit or ground), and storage position within the experimental hardware. The data were studied by analysis of variance. Initially, type of bag and orbital status were main factors; later more detailed analyses were made on specific issues such as position in the hardware and specific plastic. If the analysis of variance indicated a statistical significance at the 5 percent level the corresponding p-value was reported.

  15. OPM: The Open Porous Media Initiative

    NASA Astrophysics Data System (ADS)

    Flemisch, B.; Flornes, K. M.; Lie, K.; Rasmussen, A.

    2011-12-01

    The principal objective of the Open Porous Media (OPM) initiative is to develop a simulation suite that is capable of modeling industrially and scientifically relevant flow and transport processes in porous media and bridge the gap between the different application areas of porous media modeling, including reservoir mechanics, CO2 sequestration, biological systems, and product development of engineered media. The OPM initiative will provide a long-lasting, efficient, and well-maintained open-source software for flow and transport in porous media built on modern software principles. The suite is released under the GNU General Public License (GPL). Our motivation is to provide a means to unite industry and public research on simulation of flow and transport in porous media. For academic users, we seek to provide a software infrastructure that facilitates testing of new ideas on models with industry-standard complexity, while at the same time giving the researcher control over discretization and solvers. Similarly, we aim to accelerate the technology transfer from academic institutions to professional companies by making new research results available as free software of professional standard. The OPM initiative is currently supported by six research groups in Norway and Germany and funded by existing grants from public research agencies as well as from Statoil Petroleum and Total E&P Norge. However, a full-scale development of the OPM initiative requires substantially more funding and involvement of more research groups and potential end users. In this talk, we will provide an overview of the current activities in the OPM initiative. Special emphasis will be given to the demonstration of the synergies achieved by combining the strengths of individual open-source software components. In particular, a new fully implicit solver developed within the DUNE-based simulator DuMux could be enhanced by the ability to read industry-standard Eclipse input files and to run on

  16. Ontario's Student Voice Initiative

    ERIC Educational Resources Information Center

    Courtney, Jean

    2014-01-01

    This article describes in some detail aspects of the Student Voice initiative funded and championed by Ontario's Ministry of Education since 2008. The project enables thousands of students to make their voices heard in meaningful ways and to participate in student-led research. Some students from grades 7 to 12 become members of the Student…

  17. Financial planning for major initiatives: a framework for success.

    PubMed

    Harris, John M

    2007-11-01

    A solid framework for assessing a major strategic initiative consists of four broad steps: Initial considerations, including level of analysis required and resources that will be brought to bear. Preliminary financial estimates for board approval to further assess the initiative. Assessment of potential partners' interest in the project. Feasibility analysis for board green light.

  18. Global cancer research initiative

    PubMed Central

    Love, Richard R

    2010-01-01

    Cancer is an increasing problem for low- and middle-income countries undergoing an epidemiologic transition from dominantly acute communicable disease to more frequent chronic disease with increased public health successes in the former domain. Progress against cancer in high-income countries has been modest and has come at enormous expense. There are several well-conceived global policy and planning initiatives which, with adequate political will, can favorably impact the growing global cancer challenges. Most financial resources for cancer, however, are spent on diagnosis and management of patients with disease in circumstances where specific knowledge about effective approaches is significantly limited, and the majority of interventions, other than surgery, are not cost-effective in resource-limited countries by global standards. In summary, how to intervene effectively on a global scale for the majority of citizens who develop cancer is poorly defined. In contrast to technology-transfer approaches, markedly increased clinical research activities are more likely to benefit cancer sufferers. In these contexts, a global cancer research initiative is proposed, and mechanisms for realizing such an effort are suggested. PMID:21188101

  19. Combat Wound Initiative program.

    PubMed

    Stojadinovic, Alexander; Elster, Eric; Potter, Benjamin K; Davis, Thomas A; Tadaki, Doug K; Brown, Trevor S; Ahlers, Stephen; Attinger, Christopher E; Andersen, Romney C; Burris, David; Centeno, Jose; Champion, Hunter; Crumbley, David R; Denobile, John; Duga, Michael; Dunne, James R; Eberhardt, John; Ennis, William J; Forsberg, Jonathan A; Hawksworth, Jason; Helling, Thomas S; Lazarus, Gerald S; Milner, Stephen M; Mullick, Florabel G; Owner, Christopher R; Pasquina, Paul F; Patel, Chirag R; Peoples, George E; Nissan, Aviram; Ring, Michael; Sandberg, Glenn D; Schaden, Wolfgang; Schultz, Gregory S; Scofield, Tom; Shawen, Scott B; Sheppard, Forest R; Stannard, James P; Weina, Peter J; Zenilman, Jonathan M

    2010-07-01

    The Combat Wound Initiative (CWI) program is a collaborative, multidisciplinary, and interservice public-private partnership that provides personalized, state-of-the-art, and complex wound care via targeted clinical and translational research. The CWI uses a bench-to-bedside approach to translational research, including the rapid development of a human extracorporeal shock wave therapy (ESWT) study in complex wounds after establishing the potential efficacy, biologic mechanisms, and safety of this treatment modality in a murine model. Additional clinical trials include the prospective use of clinical data, serum and wound biomarkers, and wound gene expression profiles to predict wound healing/failure and additional clinical patient outcomes following combat-related trauma. These clinical research data are analyzed using machine-based learning algorithms to develop predictive treatment models to guide clinical decision-making. Future CWI directions include additional clinical trials and study centers and the refinement and deployment of our genetically driven, personalized medicine initiative to provide patient-specific care across multiple medical disciplines, with an emphasis on combat casualty care.

  20. 29 CFR 1990.142 - Initiation of a rulemaking.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... (CONTINUED) IDENTIFICATION, CLASSIFICATION, AND REGULATION OF POTENTIAL OCCUPATIONAL CARCINOGENS Regulation of Potential Occupational Carcinogens § 1990.142 Initiation of a rulemaking. Where the Secretary decides to regulate a potential occupational carcinogen, the Secretary shall initiate a rulemaking...