Sample records for aare kuusik jt

  1. Novel (ovario) leukodystrophy related to AARS2 mutations

    PubMed Central

    Dallabona, Cristina; Diodato, Daria; Kevelam, Sietske H.; Haack, Tobias B.; Wong, Lee-Jun; Salomons, Gajja S.; Baruffini, Enrico; Melchionda, Laura; Mariotti, Caterina; Strom, Tim M.; Meitinger, Thomas; Prokisch, Holger; Chapman, Kim; Colley, Alison; Rocha, Helena; Őunap, Katrin; Schiffmann, Raphael; Salsano, Ettore; Savoiardo, Mario; Hamilton, Eline M.; Abbink, Truus E. M.; Wolf, Nicole I.; Ferrero, Ileana; Lamperti, Costanza; Zeviani, Massimo; Vanderver, Adeline

    2014-01-01

    Objectives: The study was focused on leukoencephalopathies of unknown cause in order to define a novel, homogeneous phenotype suggestive of a common genetic defect, based on clinical and MRI findings, and to identify the causal genetic defect shared by patients with this phenotype. Methods: Independent next-generation exome-sequencing studies were performed in 2 unrelated patients with a leukoencephalopathy. MRI findings in these patients were compared with available MRIs in a database of unclassified leukoencephalopathies; 11 patients with similar MRI abnormalities were selected. Clinical and MRI findings were investigated. Results: Next-generation sequencing revealed compound heterozygous mutations in AARS2 encoding mitochondrial alanyl-tRNA synthetase in both patients. Functional studies in yeast confirmed the pathogenicity of the mutations in one patient. Sanger sequencing revealed AARS2 mutations in 4 of the 11 selected patients. The 6 patients with AARS2 mutations had childhood- to adulthood-onset signs of neurologic deterioration consisting of ataxia, spasticity, and cognitive decline with features of frontal lobe dysfunction. MRIs showed a leukoencephalopathy with striking involvement of left-right connections, descending tracts, and cerebellar atrophy. All female patients had ovarian failure. None of the patients had signs of a cardiomyopathy. Conclusions: Mutations in AARS2 have been found in a severe form of infantile cardiomyopathy in 2 families. We present 6 patients with a new phenotype caused by AARS2 mutations, characterized by leukoencephalopathy and, in female patients, ovarian failure, indicating that the phenotypic spectrum associated with AARS2 variants is much wider than previously reported. PMID:24808023

  2. Alkali-aggregate reactivity (AAR) facts book.

    DOT National Transportation Integrated Search

    2013-03-01

    This document provides detailed information on alkali-aggregate reactivity (AAR). It primarily discusses alkali-silica reaction (ASR), covering the chemistry, symptoms, test methods, prevention, specifications, diagnosis and prognosis, and mitigation...

  3. Fusion Plasma Performance and Confinement Studies on JT-60 and JT-60U

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kamada, Y.; Fujita, T.; Ishida, S.

    2002-09-15

    Fusion plasma performance and confinement studies on JT-60 and JT-60U are reviewed. With the main aim of providing a physics basis for ITER and the steady-state tokamak reactors, JT-60/JT-60U has been developing and optimizing the operational concepts, and extending the discharge regimes toward sustainment of high integrated performance in the reactor relevant parameter regime. In addition to achievement of high fusion plasma performances such as the equivalent breakeven condition (Q{sub DT}{sup eq} up to 1.25) and a high fusion triple product n{sub D}(0){tau}{sub E}T{sub i}(0) = 1.5 x 10{sup 21} m{sup -3}skeV, JT-60U has demonstrated the integrated performance of highmore » confinement, high {beta}{sub N}, full non-inductive current drive with a large fraction of bootstrap current. These favorable performances have been achieved in the two advanced operation regimes, the reversed magnetic shear (RS) and the weak magnetic shear (high-{beta}{sub p}) ELMy H modes characterized by both internal transport barriers (ITB) and edge transport barriers (ETB). The key factors in optimizing these plasmas towards high integrated performance are control of profiles of current, pressure, rotation, etc. utilizing a variety of heating, current drive, torque input, and particle control capabilities and high triangularity operation. As represented by discovery of ITBs (density ITB in the central pellet mode, ion temperature ITB in the high-{beta}{sub p} mode, and electron temperature ITB in the reversed shear mode), confinement studies in JT-60/JT-60U have been emphasizing freedom and also restriction of radial profiles of temperature and density. In addition to characterization of confinement and analyses of transport properties of the OH, the L-mode, the H-mode, the pellet mode, the high-{beta}{sub p} mode, and the RS mode, JT-60U has clarified formation conditions, spatial structures and dynamics of edge and internal transport barriers, and evaluated effects of repetitive MHD

  4. Structural basis for dual roles of Aar2p in U5 snRNP assembly

    PubMed Central

    Weber, Gert; Cristão, Vanessa F.; Santos, Karine F.; Jovin, Sina Mozaffari; Heroven, Anna C.; Holton, Nicole; Lührmann, Reinhard; Beggs, Jean D.; Wahl, Markus C.

    2013-01-01

    Yeast U5 small nuclear ribonucleoprotein particle (snRNP) is assembled via a cytoplasmic precursor that contains the U5-specific Prp8 protein but lacks the U5-specific Brr2 helicase. Instead, pre-U5 snRNP includes the Aar2 protein not found in mature U5 snRNP or spliceosomes. Aar2p and Brr2p bind competitively to a C-terminal region of Prp8p that comprises consecutive RNase H-like and Jab1/MPN-like domains. To elucidate the molecular basis for this competition, we determined the crystal structure of Aar2p in complex with the Prp8p RNase H and Jab1/MPN domains. Aar2p binds on one side of the RNase H domain and extends its C terminus to the other side, where the Jab1/MPN domain is docked onto a composite Aar2p–RNase H platform. Known Brr2p interaction sites of the Jab1/MPN domain remain available, suggesting that Aar2p-mediated compaction of the Prp8p domains sterically interferes with Brr2p binding. Moreover, Aar2p occupies known RNA-binding sites of the RNase H domain, and Aar2p interferes with binding of U4/U6 di-snRNA to the Prp8p C-terminal region. Structural and functional analyses of phospho-mimetic mutations reveal how phosphorylation reduces affinity of Aar2p for Prp8p and allows Brr2p and U4/U6 binding. Our results show how Aar2p regulates both protein and RNA binding to Prp8p during U5 snRNP assembly. PMID:23442228

  5. Animation Augmented Reality Book Model (AAR Book Model) to Enhance Teamwork

    ERIC Educational Resources Information Center

    Chujitarom, Wannaporn; Piriyasurawong, Pallop

    2017-01-01

    This study aims to synthesize an Animation Augmented Reality Book Model (AAR Book Model) to enhance teamwork and to assess the AAR Book Model to enhance teamwork. Samples are five specialists that consist of one animation specialist, two communication and information technology specialists, and two teaching model design specialists, selected by…

  6. The Automated Aircraft Rework System (AARS): A system integration approach

    NASA Technical Reports Server (NTRS)

    Benoit, Michael J.

    1994-01-01

    The Mercer Engineering Research Center (MERC), under contract to the United States Air Force (USAF) since 1989, has been actively involved in providing the Warner Robins Air Logistics Center (WR-ALC) with a robotic workcell designed to perform rework automated defastening and hole location/transfer operations on F-15 wings. This paper describes the activities required to develop and implement this workcell, known as the Automated Aircraft Rework System (AARS). AARS is scheduled to be completely installed and in operation at WR-ALC by September 1994.

  7. A novel AARS mutation in a family with dominant myeloneuropathy.

    PubMed

    Motley, William W; Griffin, Laurie B; Mademan, Inès; Baets, Jonathan; De Vriendt, Els; De Jonghe, Peter; Antonellis, Anthony; Jordanova, Albena; Scherer, Steven S

    2015-05-19

    To determine the genetic cause of neurodegeneration in a family with myeloneuropathy. We studied 5 siblings in a family with a mild, dominantly inherited neuropathy by clinical examination and electrophysiology. One patient had a sural nerve biopsy. After ruling out common genetic causes of axonal Charcot-Marie-Tooth disease, we sequenced 3 tRNA synthetase genes associated with neuropathy. All affected family members had a mild axonal neuropathy, and 3 of 4 had lower extremity hyperreflexia, evidence of a superimposed myelopathy. A nerve biopsy showed evidence of chronic axonal loss. All affected family members had a heterozygous missense mutation c.304G>C (p.Gly102Arg) in the alanyl-tRNA synthetase (AARS) gene; this allele was not identified in unaffected individuals or control samples. The equivalent change in the yeast ortholog failed to complement a strain of yeast lacking AARS function, suggesting that the mutation is damaging. A novel mutation in AARS causes a mild myeloneuropathy, a novel phenotype for patients with mutations in one of the tRNA synthetase genes. © 2015 American Academy of Neurology.

  8. JT8D engine performance retention

    NASA Technical Reports Server (NTRS)

    James, A. D.; Weisel, D. R.

    1981-01-01

    The attractive performance retention characteristics of the JT8D engine are described. Because of its moderate bypass ratio and turbine temperature, and stiff structural design, the performance retention versus flight cycles of the JT8D engine sets a standard that is difficult for other engines to equal. In addition, the significant benefits of refurbishment of the JT8D engine are presented. Cold section refurbishment offers thrust specific fuel consumption improvements of up to 2 percent and payback in less than a year, making a very attractive investment option for the airlines.

  9. Cooling-capacity characteristics of Helium-4 JT cryocoolers

    NASA Astrophysics Data System (ADS)

    Wang, Y. L.; Liu, D. L.; Gan, Z. H.; Guo, Y. X.; Shen, Y. W.; Chen, S. F.

    2017-12-01

    Cooling capacity of a Helium-4 JT cryocooler may be achieved at a temperature higher than liquid helium temperature. The latent cooling capacity, which should be obtained at liquid helium temperature, is defined as a special part of cooling capacity. With the thermodynamic analysis on steady working conditions of a Helium-4 JT cryocooler, its cooling capacity and temperature characteristics are presented systematically. The effects of precooling temperature and high pressure on the cooling capacity and latent cooling capacity are illustrated. Furthermore, the JT cryocoolers using hydrogen and neon as the working fluids are also discussed. It is shown that helium JT cryocooler has a special cooling capacity characteristic which does not exist in JT cryocoolers using other pure working fluids.

  10. Development of the JT-60SA Neutral Beam Injectors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hanada, M.; Kojima, A.; Inoue, T.

    2011-09-26

    This paper describes the development of the neutral beam (NB) systems on JT-60SA, where 30-34 MW D{sup 0} beams are required to be injected for 100 s. A 30 s operation of the NB injectors suggests that existing beamline components and positive ion sources on JT-60U can be reused without the modifications on JT-60 SA. The JT-60 negative ion source was modified to improve the voltage holding capability, which leads to a successful acceleration of 2.8 A H{sup -} ion beam up to 500 keV of the rated acceleration energy for JT-60SA.

  11. IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway

    PubMed Central

    Malkani, Niyati; Jansson, Thomas; Gupta, Madhulika B.

    2017-01-01

    Insulin-like growth factor-1 (IGF-I) is the key regulator of fetal growth. IGF-I bioavailability is markedly diminished by IGF binding protein-1 (IGFBP-1) phosphorylation. Leucine deprivation strongly induces IGFBP-1hyperphosphorylation, and plays an important role in fetal growth restriction (FGR). FGR is characterized by decreased amino acid availability, which activates the amino acid response (AAR) and inhibits the mechanistic target of rapamycin (mTOR) pathway. We investigated the role of AAR and mTOR in mediating IGFBP-1 secretion and phosphorylation in HepG2 cells in leucine deprivation. mTOR inhibition (rapamycin or raptor+rictor siRNA), or activation (DEPTOR siRNA) demonstrated a role of mTOR in leucine deprivation-induced IGFBP-1 secretion but not phosphorylation. When the AAR was blocked (U0126, or ERK/GCN2 siRNA), both IGFBP-1 secretion and phosphorylation (Ser101/Ser119/Ser169) due to leucine deprivation were prevented. CK2 inhibition by TBB also attenuated IGFBP-1 phosphorylation in leucine deprivation. These results suggest that the AAR and mTOR independently regulate IGFBP-1 secretion and phosphorylation in leucine deprivation. PMID:25957086

  12. Recent progress of the JT-60SA project

    NASA Astrophysics Data System (ADS)

    Shirai, H.; Barabaschi, P.; Kamada, Y.; the JT-60SA Team

    2017-10-01

    The JT-60SA project has been implemented for the purpose of an early realization of fusion energy. With a powerful and versatile NBI and ECRF system, a flexible plasma-shaping capability, and various kinds of in-vessel coils to suppress MHD instabilities, JT-60SA plays an essential role in addressing the key physics and engineering issues of ITER and DEMO. It aims to achieve the long sustainment of high integrated performance plasmas under the high β N condition required in DEMO. The fabrication and installation of components and systems of JT-60SA procured by the EU and Japan are steadily progressing. The installation of toroidal field (TF) coils around the vacuum vessel started in December 2016. The commissioning of the cryogenic system and power supply system has been implemented in the Naka site, and JT-60SA will start operation in 2019. The JT-60SA research plan covers a wide area of issues in ITER and DEMO relevant operation regimes, and has been regularly updated on the basis of intensive discussion among European and Japanese researchers.

  13. Analysis of ELM stability with extended MHD models in JET, JT-60U and future JT-60SA tokamak plasmas

    NASA Astrophysics Data System (ADS)

    Aiba, N.; Pamela, S.; Honda, M.; Urano, H.; Giroud, C.; Delabie, E.; Frassinetti, L.; Lupelli, I.; Hayashi, N.; Huijsmans, G.; JET Contributors, the; Research Unit, JT-60SA

    2018-01-01

    The stability with respect to a peeling-ballooning mode (PBM) was investigated numerically with extended MHD simulation codes in JET, JT-60U and future JT-60SA plasmas. The MINERVA-DI code was used to analyze the linear stability, including the effects of rotation and ion diamagnetic drift ({ω }* {{i}}), in JET-ILW and JT-60SA plasmas, and the JOREK code was used to simulate nonlinear dynamics with rotation, viscosity and resistivity in JT-60U plasmas. It was validated quantitatively that the ELM trigger condition in JET-ILW plasmas can be reasonably explained by taking into account both the rotation and {ω }* {{i}} effects in the numerical analysis. When deuterium poloidal rotation is evaluated based on neoclassical theory, an increase in the effective charge of plasma destabilizes the PBM because of an acceleration of rotation and a decrease in {ω }* {{i}}. The difference in the amount of ELM energy loss in JT-60U plasmas rotating in opposite directions was reproduced qualitatively with JOREK. By comparing the ELM affected areas with linear eigenfunctions, it was confirmed that the difference in the linear stability property, due not to the rotation direction but to the plasma density profile, is thought to be responsible for changing the ELM energy loss just after the ELM crash. A predictive study to determine the pedestal profiles in JT-60SA was performed by updating the EPED1 model to include the rotation and {ω }* {{i}} effects in the PBM stability analysis. It was shown that the plasma rotation predicted with the neoclassical toroidal viscosity degrades the pedestal performance by about 10% by destabilizing the PBM, but the pressure pedestal height will be high enough to achieve the target parameters required for the ITER-like shape inductive scenario in JT-60SA.

  14. Chemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A2AAR Dual Binding Scaffold

    PubMed Central

    Cruz-Monteagudo, Maykel; Borges, Fernanda; Cordeiro, M. Natália D. S.; Helguera, Aliuska Morales; Tejera, Eduardo; Paz-y-Miño, Cesar; Sánchez-Rodríguez, Aminael; Perera-Sardiña, Yunier; Perez-Castillo, Yunierkis

    2017-01-01

    Background: In the context of the current drug discovery efforts to find disease modifying therapies for Parkinson´s disease (PD) the current single target strategy has proved inefficient. Consequently, the search for multi-potent agents is attracting more and more attention due to the multiple pathogenetic factors implicated in PD. Multiple evidences points to the dual inhibition of the monoamine oxidase B (MAO-B), as well as adenosine A2A receptor (A2AAR) blockade, as a promising approach to prevent the neurodegeneration involved in PD. Currently, only two chemical scaffolds has been proposed as potential dual MAO-B inhibitors/A2AAR antagonists (caffeine derivatives and benzothiazinones). Methods: In this study, we conduct a series of chemoinformatics analysis in order to evaluate and advance the potential of the chromone nucleus as a MAO-B/A2AAR dual binding scaffold. Results: The information provided by SAR data mining analysis based on network similarity graphs and molecular docking studies support the suitability of the chromone nucleus as a potential MAO-B/A2AAR dual binding scaffold. Additionally, a virtual screening tool based on a group fusion similarity search approach was developed for the prioritization of potential MAO-B/A2AAR dual binder candidates. Among several data fusion schemes evaluated, the MEAN-SIM and MIN-RANK GFSS approaches demonstrated to be efficient virtual screening tools. Then, a combinatorial library potentially enriched with MAO-B/A2AAR dual binding chromone derivatives was assembled and sorted by using the MIN-RANK and then the MEAN-SIM GFSS VS approaches. Conclusion: The information and tools provided in this work represent valuable decision making elements in the search of novel chromone derivatives with a favorable dual binding profile as MAO-B inhibitors and A2AAR antagonists with the potential to act as a disease-modifying therapeutic for Parkinson´s disease. PMID:28093976

  15. Transient simulation of a miniature Joule-Thomson (J-T) cryocooler with and without the distributed J-T effect

    NASA Astrophysics Data System (ADS)

    Damle, R. M.; Atrey, M. D.

    2015-01-01

    The aim of this work is to develop a transient program for the simulation of a miniature Joule-Thomson (J-T) cryocooler to predict its cool-down characteristics. A one dimensional transient model is formulated for the fluid streams and the solid elements of the recuperative heat exchanger. Variation of physical properties due to pressure and temperature is considered. In addition to the J-T expansion at the end of the finned tube, the distributed J-T effect along its length is also considered. It is observed that the distributed J-T effect leads to additional cooling of the gas in the finned tube and that it cannot be neglected when the pressure drop along the length of the finned tube is large. The mathematical model, method of resolution and the global transient algorithm, within a modular object-oriented framework, are detailed in this paper. As a part of verification and validation of the developed model, cases available in the literature are simulated and the results are compared with the corresponding numerical and experimental data.

  16. JT8D-100 turbofan engine, phase 1. [noise reduction

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The JT8D turbofan engine, widely used in short and medium range transport aircraft, contributes substantially to airport community noise. The jet noise is predominant in the JT8D engine and may be reduced in a modified engine, without loss of thrust, by increasing the airflow to reduce jet velocity. A configuration study evaluated the effects of fan airflow, fan pressure ratio, and bypass ratio on noise, thrust, and fuel comsumption. The cycle selected for the modified engine was based upon an increased diameter, single-stage fan and two additional core engine compressor stages, which replace the existing two-stage fan. Modifications were also made to the low pressure turbine to provide the increased torque required by the larger diameter fan. The resultant JT8D-100 engine models have the following characteristics at take-off thrust, compared to the current JT8D engine: Airflow and bypass ratio are increased, and fan pressure ratio and engine speed are reduced. The resultant engine is also longer, larger in diameter, and heavier than the JT8D base model, but these latter changes are compensated by the increased thrust and decreased fuel comsumption of the modified engine, thus providing the capability for maintaining the performance of the current JT8D-powered aircraft.

  17. Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR).

    PubMed

    Gomez, Sandra; Adalid-Peralta, Laura; Palafox-Fonseca, Hector; Cantu-Robles, Vito Adrian; Soberón, Xavier; Sciutto, Edda; Fragoso, Gladis; Bobes, Raúl J; Laclette, Juan P; Yauner, Luis del Pozo; Ochoa-Leyva, Adrián

    2015-05-19

    Excretory/Secretory (ES) proteins play an important role in the host-parasite interactions. Experimental identification of ES proteins is time-consuming and expensive. Alternative bioinformatics approaches are cost-effective and can be used to prioritize the experimental analysis of therapeutic targets for parasitic diseases. Here we predicted and functionally annotated the ES proteins in T. solium genome using an integration of bioinformatics tools. Additionally, we developed a novel measurement to evaluate the potential antigenicity of T. solium secretome using sequence length and number of antigenic regions of ES proteins. This measurement was formalized as the Abundance of Antigenic Regions (AAR) value. AAR value for secretome showed a similar value to that obtained for a set of experimentally determined antigenic proteins and was different to the calculated value for the non-ES proteins of T. solium genome. Furthermore, we calculated the AAR values for known helminth secretomes and they were similar to that obtained for T. solium. The results reveal the utility of AAR value as a novel genomic measurement to evaluate the potential antigenicity of secretomes. This comprehensive analysis of T. solium secretome provides functional information for future experimental studies, including the identification of novel ES proteins of therapeutic, diagnosis and immunological interest.

  18. Genome analysis of Excretory/Secretory proteins in Taenia solium reveals their Abundance of Antigenic Regions (AAR)

    PubMed Central

    Gomez, Sandra; Adalid-Peralta, Laura; Palafox-Fonseca, Hector; Cantu-Robles, Vito Adrian; Soberón, Xavier; Sciutto, Edda; Fragoso, Gladis; Bobes, Raúl J.; Laclette, Juan P.; Yauner, Luis del Pozo; Ochoa-Leyva, Adrián

    2015-01-01

    Excretory/Secretory (ES) proteins play an important role in the host-parasite interactions. Experimental identification of ES proteins is time-consuming and expensive. Alternative bioinformatics approaches are cost-effective and can be used to prioritize the experimental analysis of therapeutic targets for parasitic diseases. Here we predicted and functionally annotated the ES proteins in T. solium genome using an integration of bioinformatics tools. Additionally, we developed a novel measurement to evaluate the potential antigenicity of T. solium secretome using sequence length and number of antigenic regions of ES proteins. This measurement was formalized as the Abundance of Antigenic Regions (AAR) value. AAR value for secretome showed a similar value to that obtained for a set of experimentally determined antigenic proteins and was different to the calculated value for the non-ES proteins of T. solium genome. Furthermore, we calculated the AAR values for known helminth secretomes and they were similar to that obtained for T. solium. The results reveal the utility of AAR value as a novel genomic measurement to evaluate the potential antigenicity of secretomes. This comprehensive analysis of T. solium secretome provides functional information for future experimental studies, including the identification of novel ES proteins of therapeutic, diagnosis and immunological interest. PMID:25989346

  19. Present status and future prospects of the JT-60SA project

    NASA Astrophysics Data System (ADS)

    Ishida, S.; Barabaschi, P.; Kamada, Y.

    2014-10-01

    The JT-60SA project has been implemented jointly by Europe and Japan since June 2007. After the disassembly of JT-60 from the torus hall had been completed in October 2012, the project achieved the major milestone of starting the tokamak's assembly at the JAEA Naka site in January 2013 following the completion of the cryostat base in Europe and its transport to Japan. Procurement and assembly activities for components such as the superconducting magnet, cryogenic system, power supply, vacuum vessel, divertor and cryostat are progressing on track towards the start of operation in March 2019. In preparation for exploitation, the JT-60SA Research Plan was issued in December 2011, and the research integration activities are addressing JT-60SA data management, validation and analysis tools. This paper overviews the latest evolution of the project in terms of construction and exploitation for JT-60SA.

  20. JT8D and JT9D jet engine performance improvement program. Task 1: Feasibility analysis

    NASA Technical Reports Server (NTRS)

    Gaffin, W. O.; Webb, D. E.

    1979-01-01

    JT8D and JT9D component performance improvement concepts which have a high probability of incorporation into production engines were identified and ranked. An evaluation method based on airline payback period was developed for the purpose of identifying the most promising concepts. The method used available test data and analytical models along with conceptual/preliminary designs to predict the performance improvements, weight, installation characteristics, cost for new production and retrofit, maintenance cost, and qualitative characteristics of candidate concepts. These results were used to arrive at the concept payback period, which is the time required for an airline to recover the investment cost of concept implementation.

  1. Halogen and trace element geochemistry in Mid-Ocean Ridge basalts from the Australian-Antarctic Ridge (AAR)

    NASA Astrophysics Data System (ADS)

    Yang, Y. S.; Seo, J. H.; Park, S. H.; Kim, T.

    2015-12-01

    Australian-Antarctic Ridge (AAR) is an extension of easternmost SE Indian Mid-Ocean Ridge (MOR).We collected volcanic glasses from the "in-axis" of the KR1 and KR2 MOR, and the overlapping zones of the KR1 MOR and the nearby seamounts ("KR1 mixing"). We determined trace and halogen elements in the glasses. Halogen concentrations and its ratios in the glasses are important to understand the mantle metasomatism and volatile recycling. 52 of the collected glasses are "primitive" (higher than 6 wt% MgO), while 3 of them have rather "evolved" composition (MgO wt% of 1.72, 2.95 and 4.15). K2O concentrations and Th/Sc ratios in the glasses show a negative correlation with its MgO concentration. Incompatible element ratios such as La/Sm are rather immobile during a magma differentiation so the ratios are important to understand mantle composition (Hofmann et al. 2003). La/Sm ratios in the glasses are 0.95 ~ 3.28 suggesting that the AAR basalts can be classified into T-MORB and E-MORB (Schilling et al., 1983). La/Sm ratios are well-correlated with incompatible elements such as U, Ba, Nb, and negatively correlated with compatible elements such as Sc, Eu2+, Mg. The AAR glasses contain detectable halogen elements. The "KR1 mixing" glasses in halogen elements are more abundant than "in-axis" the glasses. Cl is the least variable element compared to the other halogens such as Br and I in the AAR. The "KR1 mixing" glasses have the largest variations of Br/Cl ratios compared to the "in-axis" glasses. The Cl/Br and Th/Sc ratios in the "in-axis" glasses and in the "KR1 mixing" glasses show positive and negative correlations, respectively. The Br-rich glasses in the "KR1 mixing" zone might be explained by a recycled Br-rich oceanic slab of paleo-subduction or by a hydrothermal alteration in the AAR. I composition in the glasses does not show a correlation other trace elements. The K/Cl and K/Ti ratios in the AAR glasses are similar to the basalts from the Galapagos Spreading Center

  2. Mixed-refrigerant Joule-Thomson (MR JT) mini-cryocoolers

    NASA Astrophysics Data System (ADS)

    Tzabar, Nir

    2014-01-01

    This paper presents the progress in our ongoing research on Mixed-Refrigerant (MR) Joule-Thomson (JT) cryocoolers. The research begun by exploring different MRs and testing various compressors: oil-lubricated and oil-free, reciprocating and linear, custom-made and commercial. Closed-cycle JT cryocoolers benefit from the fact that the compressor might be located far from the cold-end and thus there are no moving parts, no vibrations, and no heat emission near the cold-end. As a consequence, the compressor may be located where there are no severe size limitations, its heat can be conveniently removed, and it can be easily maintained. However, in some applications there is still a demand for a small compressor to drive a JT cryocooler although it is located far from the cooled device. Recently, we have developed a miniature oil-free compressor for MR JT cryocoolers that weighs about 700 g and its volume equals about 300 cc. The cryocooler operates with a MR that contains Ne, N2, and Hydrocarbons. This MR has been widely investigated with different compressors and varying operating conditions and proved to be stable. The current research investigates the performances of MR JT mini-cryocooler operating with the MR mentioned above, driven with our miniature compressor, and a cold-finger prototype. A Dewar with heat load of about 230 mW is cooled to about 80 K at ambient temperatures between 0°C and 40°C. The experimental results obtained are stable and demonstrate the ability to control the cooling temperature by changing the rotation speed of the compressor.

  3. Results of acoustic testing of the JT8D-109 refan engines

    NASA Technical Reports Server (NTRS)

    Burdsall, E. A.; Brochu, F. P.; Scaramella, V. M.

    1975-01-01

    A JT8D engine was modified to reduce jet noise levels by 6-8 PNdB at takeoff power without increasing fan generated noise levels. Designated the JT8D-109, the modified engines featured a larger single stage fan, and acoustic treatment in the fan discharge ducts. Noise levels were measured on an outdoor test facility for eight engine/acoustic treatment configurations. Compared to the baseline JT8D, the fully treated JT8D-109 showed reductions of 6 PNdB at takeoff, and 11 PNdB at a typical approach power setting.

  4. Combined Brayton-JT cycles with refrigerants for natural gas liquefaction

    NASA Astrophysics Data System (ADS)

    Chang, Ho-Myung; Park, Jae Hoon; Lee, Sanggyu; Choe, Kun Hyung

    2012-06-01

    Thermodynamic cycles for natural gas liquefaction with single-component refrigerants are investigated under a governmental project in Korea, aiming at new processes to meet the requirements on high efficiency, large capacity, and simple equipment. Based upon the optimization theory recently published by the present authors, it is proposed to replace the methane-JT cycle in conventional cascade process with a nitrogen-Brayton cycle. A variety of systems to combine nitrogen-Brayton, ethane-JT and propane-JT cycles are simulated with Aspen HYSYS and quantitatively compared in terms of thermodynamic efficiency, flow rate of refrigerants, and estimated size of heat exchangers. A specific Brayton-JT cycle is suggested with detailed thermodynamic data for further process development. The suggested cycle is expected to be more efficient and simpler than the existing cascade process, while still taking advantage of easy and robust operation with single-component refrigerants.

  5. Control of Current Profile and Instability by Radiofrequency Wave Injection in JT-60U and Its Applicability in JT-60SA

    NASA Astrophysics Data System (ADS)

    Isayama, A.; Suzuki, T.; Hayashi, N.; Ide, S.; Hamamatsu, K.; Fujita, T.; Hosoyama, H.; Kamada, Y.; Nagasaki, K.; Oyama, N.; Ozeki, T.; Sakata, S.; Seki, M.; Sueoka, M.; Takechi, M.; Urano, H.

    2007-09-01

    Recent results of control of current profile and instability using radiofrequency wave in JT-60U and prediction analysis in JT-60SA are descried. In JT-60U, control of current profile in high-beta regime was demonstrated by using a real-time system, where the motional Stark effect diagnostic and lower hybrid wave were used as a detector and actuator, respectively. The minimum value of the safety factor was raised from 1.3 to 1.7 so as to follow the commanded value. Complete stabilization of a neoclassical tearing mode (NTM) with the poloidal mode number m = 2 and the toroidal mode number n = 1 was demonstrated using electron cyclotron (EC) current drive. By scanning the location of EC current drive in detail, strong stabilization effect was found for misalignment less than about half of the full island width. In addition, destabilization of the 2/1 NTM was observed for misalignment comparable to the full island width. Simulation of NTM stabilization in JT-60SA was performed by using the TOPICS code combined with the modified Rutherford equation. The TOPICS simulation showed that complete stabilization can be achieved more effectively by optimizing the EC wave injection angle and modulating the EC wave.

  6. Control of Current Profile and Instability by Radiofrequency Wave Injection in JT-60U and Its Applicability in JT-60SA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Isayama, A.; Suzuki, T.; Hayashi, N.

    2007-09-28

    Recent results of control of current profile and instability using radiofrequency wave in JT-60U and prediction analysis in JT-60SA are descried. In JT-60U, control of current profile in high-beta regime was demonstrated by using a real-time system, where the motional Stark effect diagnostic and lower hybrid wave were used as a detector and actuator, respectively. The minimum value of the safety factor was raised from 1.3 to 1.7 so as to follow the commanded value. Complete stabilization of a neoclassical tearing mode (NTM) with the poloidal mode number m = 2 and the toroidal mode number n = 1 wasmore » demonstrated using electron cyclotron (EC) current drive. By scanning the location of EC current drive in detail, strong stabilization effect was found for misalignment less than about half of the full island width. In addition, destabilization of the 2/1 NTM was observed for misalignment comparable to the full island width. Simulation of NTM stabilization in JT-60SA was performed by using the TOPICS code combined with the modified Rutherford equation. The TOPICS simulation showed that complete stabilization can be achieved more effectively by optimizing the EC wave injection angle and modulating the EC wave.« less

  7. A subaquatic moraine complex in overdeepened Lake Thun (Switzerland) unravelling the deglaciation history of the Aare Glacier

    NASA Astrophysics Data System (ADS)

    Fabbri, S. C.; Buechi, M. W.; Horstmeyer, H.; Hilbe, M.; Hübscher, C.; Schmelzbach, C.; Weiss, B.; Anselmetti, F. S.

    2018-05-01

    To investigate the history of the Aare Glacier and its overdeepened valley, a high-resolution multibeam bathymetric dataset and a 2D multi-channel reflection seismic dataset were acquired on perialpine Lake Thun (Switzerland). The overdeepened basin was formed by a combination of tectonically predefined weak zones and glacial erosion during several glacial cycles. In the deepest region of the basin, top of bedrock lies at ∼200 m below sea level, implying more than 750 m of overdeepening with respect to the current fluvial base level (i.e. lake level). Seismic stratigraphic analysis reveals the evolution of the basin and indicates a subaquatic moraine complex marked by high-amplitude reflections below the outermost edge of a morphologically distinct platform in the southeastern part of the lake. This stack of seven subaquatic terminal moraine crests was created by a fluctuating, "quasi-stagnant" grounded Aare Glacier during its overall recessional phase. Single packages of overridden moraine crests are seismically distuinguishable, which show a transition downstream into prograding clinoforms with foresets at the ice-distal slope. The succession of subaquatic glacial sequences (foresets and adjacent bottomsets) represent one fifth of the entire sedimentary thickness. Exact time constraints concerning the deglacial history of the Aare Glacier are very sparse. However, existing 10Be exposure ages from the accumulation area of the Aare Glacier and radiocarbon ages from a Late-Glacial lake close to the outlet of Lake Thun indicate that the formation of the subaquatic moraine complex and the associated sedimentary infill must have occurred in less than 1000 years, implying high sedimentation rates and rapid disintegration of the glacier. These new data improve our comprehension of the landforms associated with the ice-contact zone in water, the facies architecture of the sub- to proglacial units, the related depositional processes, and thus the retreat mechanisms of

  8. Development of New Cooling System Using Gm/jt Cryocoolers for the SKS Magnet

    NASA Astrophysics Data System (ADS)

    Aoki, K.; Haruyama, T.; Makida, Y.; Araoka, O.; Kasami, K.; Takahashi, T.; Nagae, T.; Kakiguchi, Y.; Sekimoto, M.; Tosaka, T.; Miyazaki, H.; Kuriyama, T.; Ono, M.; Orikasa, T.; Tsuchihashi, T.; Hirata, Y.

    2008-03-01

    We plan to develop a new improved cooling system for the Superconducting Kaon Spectrometer (SKS) magnet and transfer the magnet to the K1.8 beamline of the Hadron Hall of the Japan Proton Accelerator Research Complex (J-PARC) for further use in nuclear physics experiments. To replace the present 300 W cryogenic system, we will adopt a new cooling method that uses 4 K Gifford-McMahon/Joule-Thomson (GM/JT) cryocoolers. In order to decide a practical design for the new liquid helium reservoir of the magnet, which will be equipped with GM/JT cryocoolers, cooling tests on a GM/JT cryocooler were performed from February to March 2007. We constructed a new cooling test stand with a GM/JT cryocooler and measured the cooling capacities under several thermal shield temperatures with or without a baffle, which helped prevent convection. Based on the test results, we have finally decided to adopt three GM/JT cryocoolers for the new SKS along with a baffle and an additional dedicated GM cooler to cool the thermal shield of the GM/JT ports.

  9. Program for refan JT8D engine design, fabrication and test, phase 2

    NASA Technical Reports Server (NTRS)

    Glass, J. A.; Zimmerman, E. S.; Scaramella, V. M.

    1975-01-01

    The objective of the JT8D refan program was to design, fabricate, and test certifiable modifications of the JT8D engine which would reduce noise generated by JT8D powered aircraft. This was to be accomplished without affecting reliability and maintainability, at minimum retrofit cost, and with no performance penalty. The mechanical design, engine performance and stability characteristics at sea-level and altitude, and the engine noise characteristics of the test engines are documented. Results confirmed the structural integrity of the JT8D-109. Engine operation was stable throughout the airplane flight envelope. Fuel consumption of the test engines was higher than that required to meet the goal of no airplane performance penalty, but the causes were identified and corrected during a normal pre-certification engine development program. Compared to the baseline JT8D-109 engine, the acoustically treated JT8D-109 engine showed noise reductions of 6 PNdB at takeoff and 11 PNdB at a typical approach power setting.

  10. Amino acid racemization analysis (AAR) as a successful tool for dating Holocene coastal sediments: Stratigraphy of a barrier island spit (Southern Sylt/North Sea)

    NASA Astrophysics Data System (ADS)

    Tillmann, Tanja; Ziehe, Daniel

    2014-05-01

    Dating of Holocene sediments in shallow coastal areas of the German North Sea by conventional techniques is commonly problematic. In particular the marine reservoir effect of radiocarbon means that radiocarbon dating cannot be applied to sediments younger than about 400 years. Amino acid racemization dating (AAR) is a viable alternative for dating young sediments. The method is based on the determination of ratios of D and L amino acid enantiomers in organic matrices of biogenic carbonates. In this study we use AAR as a tool for dating Holocene barrier islands sediments. Based on an AAR derived chronological framework we develop a model of barrier spit accretion which describes the interaction between extreme events, fair weather coastal processes and sedimentary development that constrains the major episodes of barrier island evolution. The stratigraphy was defined using ground-penetrating radar (GPR) surveys complemented by sedimentological coring data. The stratigraphy is then conceptualised in a AAR chronostratigraphic framework to define a chronological order and allow the development of a stratigraphic model of the evolution of Southern Sylt. The AAR data provide high temporal resolution and have been used for dating stages of barrier spit accretion. The time lines are marked as storm surge generated erosion unconformities in the stratigraphic profile. Individual shells and shell fragments of Cerastoderma edule, Mya arenaria, Mytilus edulis and Scrobicularia plana have been accumulated by short-term storm events as shell layers associated with the erosion unconformities and have been dated by AAR. Time lines reveal that the barrier spit accretion occurred episodically, and is dependant on the provided rate of sand delivery. The general trend is that sequences young to the. South. The AAR derived time lines have been verified and correlated by historic maps and sea charts. It is apparent that spit enlargement at this site increased significantly during the

  11. Performance of JT-60SA divertor Thomson scattering diagnostics

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kajita, Shin, E-mail: kajita.shin@nagoya-u.jp; Hatae, Takaki; Tojo, Hiroshi

    2015-08-15

    For the satellite tokamak JT-60 Super Advanced (JT-60SA), a divertor Thomson scattering measurement system is planning to be installed. In this study, we improved the design of the collection optics based on the previous one, in which it was found that the solid angle of the collection optics became very small, mainly because of poor accessibility to the measurement region. By improvement, the solid angle was increased by up to approximately five times. To accurately assess the measurement performance, background noise was assessed using the plasma parameters in two typical discharges in JT-60SA calculated from the SONIC code. Moreover, themore » influence of the reflection of bremsstrahlung radiation by the wall is simulated by using a ray tracing simulation. The errors in the temperature and the density are assessed based on the simulation results for three typical field of views.« less

  12. Performance of JT-60SA divertor Thomson scattering diagnostics.

    PubMed

    Kajita, Shin; Hatae, Takaki; Tojo, Hiroshi; Enokuchi, Akito; Hamano, Takashi; Shimizu, Katsuhiro; Kawashima, Hisato

    2015-08-01

    For the satellite tokamak JT-60 Super Advanced (JT-60SA), a divertor Thomson scattering measurement system is planning to be installed. In this study, we improved the design of the collection optics based on the previous one, in which it was found that the solid angle of the collection optics became very small, mainly because of poor accessibility to the measurement region. By improvement, the solid angle was increased by up to approximately five times. To accurately assess the measurement performance, background noise was assessed using the plasma parameters in two typical discharges in JT-60SA calculated from the SONIC code. Moreover, the influence of the reflection of bremsstrahlung radiation by the wall is simulated by using a ray tracing simulation. The errors in the temperature and the density are assessed based on the simulation results for three typical field of views.

  13. Performance analysis of a miniature Joule-Thomson cryocooler with and without the distributed J-T effect

    NASA Astrophysics Data System (ADS)

    Damle, Rashmin; Atrey, Milind

    2015-12-01

    Cryogenic temperatures are obtained with Joule-Thomson (J-T) cryocoolers in an easier way as compared to other cooling techniques. Miniature J-T cryocoolers are often employed for cooling of infrared sensors, cryoprobes, biological samples, etc. A typical miniature J-T cryocooler consists of a storage reservoir/compressor providing the high pressure gas, a finned tube recuperative heat exchanger, an expansion valve/orifice, and the cold end. The recuperative heat exchanger is indispensable for attaining cryogenic temperatures. The geometrical parameters and the operating conditions of the heat exchanger drastically affect the cryocooler performance in terms of cool down time and cooling effect. In the literature, the numerical models for the finned recuperative heat exchanger have neglected the distributed J-T effect. The distributed J-T effect accounts for the changes in enthalpy of the fluid due to changes of pressure in addition to those due to changes of temperature. The objective of this work is to explore the distributed J-T effect and study the performance of a miniature J-T cryocooler with and without the distributed J-T effect. A one dimensional transient model is employed for the numerical analysis of the cryocooler. Cases with different operating conditions are worked out with argon and nitrogen as working fluids.

  14. Design of distributed JT (Joule-Thomson) effect heat exchanger for superfluid 2 K cooling device

    NASA Astrophysics Data System (ADS)

    Jeong, S.; Park, C.; Kim, K.

    2018-03-01

    Superfluid at 2 K or below is readily obtained from liquid helium at 4.2 K by reducing its vapour pressure. For better cooling performance, however, the cold energy of vaporized helium at 2 K chamber can be effectively utilized in a recuperator which is specially designed in this paper for accomplishing so-called the distributed Joule-Thomson (JT) expansion effect. This paper describes the design methodology of distributed JT effect heat exchanger for 2 K JT cooling device. The newly developed heat exchanger allows continuous significant pressure drop at high-pressure part of the recuperative heat exchanger by using a capillary tube. Being different from conventional recuperative heat exchangers, the efficient JT effect HX must consider the pressure drop effect as well as the heat transfer characteristic. The heat exchanger for the distributed JT effect actively utilizes continuous pressure loss at the hot stream of the heat exchanger by using an OD of 0.64 mm and an ID of 0.4 mm capillary tube. The analysis is performed by dividing the heat exchanger into the multiple sub-units of the heat exchange part and JT valve. For more accurate estimation of the pressure drop of spirally wound capillary tube, preliminary experiments are carried out to investigate the friction factor at high Reynolds number. By using the developed pressure drop correlation and the heat transfer correlation, the specification of the heat exchanger with distributed JT effect for 2 K JT refrigerator is determined.

  15. Research on Standard and Automatic Judgment of Press-fit Curve of Locomotive Wheel-set Based on AAR Standard

    NASA Astrophysics Data System (ADS)

    Lu, Jun; Xiao, Jun; Gao, Dong Jun; Zong, Shu Yu; Li, Zhu

    2018-03-01

    In the production of the Association of American Railroads (AAR) locomotive wheel-set, the press-fit curve is the most important basis for the reliability of wheel-set assembly. In the past, Most of production enterprises mainly use artificial detection methods to determine the quality of assembly. There are cases of miscarriage of justice appear. For this reason, the research on the standard is carried out. And the automatic judgment of press-fit curve is analysed and designed, so as to provide guidance for the locomotive wheel-set production based on AAR standard.

  16. Pollution reduction technology program for class T4(JT8D) engines

    NASA Technical Reports Server (NTRS)

    Roberts, R.; Fiorentino, A. J.; Diehl, L. A.

    1977-01-01

    The technology required to develop commercial gas turbine engines with reduced exhaust emissions was demonstrated. Can-annular combustor systems for the JT8D engine family (EPA class T4) were investigated. The JT8D turbofan engine is an axial-flow, dual-spool, moderate-bypass-ratio design. It has a two-stage fan, a four-stage low-pressure compressor driven by a three-stage low-pressure turbine, and a seven-stage high-pressure compressor driven by a single-stage high-pressure turbine. A cross section of the JT8D-17 showing the mechanical configuration is given. Key specifications for this engine are listed.

  17. B747/JT9D flight loads and their effect on engine running clearances and performance deterioration; BCAC NAIL/P and WA JT9D engine diagnostics programs

    NASA Technical Reports Server (NTRS)

    Olsson, W. J.; Martin, R. L.

    1982-01-01

    Flight loads on the 747 propulsion system and resulting JT9D blade to outer airseal running clearances during representative acceptance flight and revenue flight sequences were measured. The resulting rub induced clearance changes, and engine performance changes were then analyzed to validate and refine the JT9D-7A short term performance deterioration model.

  18. Fatigue performance of AAR class A railroad wheel steel at ambient and elevated temperatures

    DOT National Transportation Integrated Search

    2005-11-05

    This paper reports on tests to measure the effect of temperature on fatigue performance of railroad wheel steel. Classical stress-life (S-N) curves were developed for AAR Class B wheel steel with specimens removed from the tread areas of an as-forged...

  19. Spatial distribution of quartz recrystallization microstructures across the Aar massif (Swiss Central Alps)

    NASA Astrophysics Data System (ADS)

    Peters, M.; Herwegh, M.

    2012-04-01

    In the Aar massif, main foliation and major deformation structures were developed during NW-SE compression associated with the Alpine orogeny (Steck 1968). To be precise, shearing at the brittle to ductile transition may have initiated at different stages between 22-20 Ma and 14-12 Ma, followed by purely brittle deformation at around 10 Ma (Rolland et al. 2009). In light of the onset of dynamic recrystallization in quartz, Bambauer et al. (2009) defined a quartz recrystallization isograd in the northern part of the Aar massif. To the south, the grain size of recrystallized grains increases due to an increase of metamorphic temperatures from N to S. The aim of the current project is to carry out quantitative analysis on changes of the dynamic and static recrystallization behavior of quartz. Across the Aar massif, two general types of microstructures have to be discriminated: (i) weakly to moderately deformed host rocks and (ii) intensely deformed mylonites to ultramylonites out of high strain shear zones. In (i), volume fraction and size of recrystallized quartz grains increase towards the S showing grain size changes from around 5 µm up to ca. 200 µm. Southern microstructures are characterized by complete recrystallization. In terms of recrystallization processes, a transition from bulging recrystallization in the N to subgrain rotation recrystallization in the S occurs. Such a change in dynamic recrystallization processes combined with a grain size increase points towards reduced differential stresses with increasing temperature. This temperature gradient is also corroborated by a switch in the active glide systems in quartz from basal to rhomb dominated glide. In contrast to the granitic host rocks, the mylonites and ultramylonites (ii) show smaller recrystallized grain sizes due to enhanced strain rates. However, they also reveal a general increase of recrystallized grain sizes from N to S. In the S, microstructures from (i) and (ii) show equidimensional

  20. QT and JT dispersion and cardiac performance in children with neonatal Bartter syndrome: a pilot study.

    PubMed

    Hacihamdioglu, Duygu Ovunc; Fidanci, Kursat; Kilic, Ayhan; Gok, Faysal; Topaloglu, Rezan

    2013-10-01

    QT dispersion and JT dispersion are simple noninvasive arrhythmogenic markers that can be used to assess the homogeneity of cardiac repolarization. The aim of this study was to assess QT and JT dispersion and their relation with left ventricular systolic and diastolic functions in children with Bartter syndrome (BS). Nine neonatal patients with BS (median age 9.7 years) and 20 controls (median age 8 years) were investigated at rest. Both study and control subjects underwent electrocardiography (ECG) in which the interval between two R waves and QT intervals, corrected QT, QT dispersion, corrected QT dispersion, JT, corrected JT, JT dispersion and corrected JT dispersion were measured with 12-lead ECG. Two-dimensional, Doppler echocardiographic examinations were performed. Patients and controls did not differ for gender and for serum levels of potassium, magnesium, and calcium (p > 0.05). Both study and control subjects had normal echocardiographic examination and baseline myocardial performance indexes. The QT dispersion and JT dispersion were significantly prolonged in patients with BS compared to those of the controls {37.5 ms [interquartile range (IQR) 32.5-40] vs. 25.5 ms (IQR 20-30), respectively, p = 0.014 and 37.5 ms (IQR 27.5-40) vs. 22.5 ms (IQR 20-30), respectively, p = 0.003}. Elevated QT and JT dispersion during asymptomatic and normokalemic periods may be risk factors for the development of cardiac complications and arrhythmias in children with BS. In these patients the need for systematic cardiac screening and management protocol is extremely important for effective prevention.

  1. Commissioning of the JT-60SA helium refrigerator

    NASA Astrophysics Data System (ADS)

    Kamiya, Koji; Natsume, Kyohei; Ohtsu, Kiichi; Oishi, Makoto; Honda, Atsushi; Kashiwa, Yoshitoshi; Kizu, Kaname; Koide, Yoshihiko; Hoa, Christine; Michel, Frederic; Roussel, Pascal; Lamaison, Valerie; Bonne, Francois; Dipietro, Enrico; Cardella, Antonino; Wanner, Manfred; Legrand, Jerome; Pudys, Vincent; Langevin, Baptiste

    2017-09-01

    The JT-60SA project will use superconducting magnets to confine the plasma and achieve a plasma current with a typical flat top duration of 100 second in purely inductive mode. The helium refrigerator has an equivalent cooling power of 9 kW at 4.5 K providing 3.7 K, 4.5 K, 50 K and 80 K for the diverter cryopump, the superconducting magnets, the HTS current leads, and the thermal shields, respectively. This paper summarizes the JT-60SA helium refrigerator commissioning activities aiming at successful operation of heat load smoothing technology to manage the 12 kW heat pulses by 9 kW cooling power using a 7000 liter liquid helium.

  2. 76 FR 72130 - Airworthiness Directives; Pratt & Whitney JT9D Series Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... the Airworthiness Limitations Section (ALS) of the manufacturer's Instructions for Continued... life-limited parts. This proposed AD would require additional revisions to the JT9D series engines ALS... all PW JT9D series turbofan engines. That AD requires revisions to the ALS of the manufacturer's ICA...

  3. MIXING STUDY FOR JT-71/72 TANKS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lee, S.

    2013-11-26

    All modeling calculations for the mixing operations of miscible fluids contained in HBLine tanks, JT-71/72, were performed by taking a three-dimensional Computational Fluid Dynamics (CFD) approach. The CFD modeling results were benchmarked against the literature results and the previous SRNL test results to validate the model. Final performance calculations were performed by using the validated model to quantify the mixing time for the HB-Line tanks. The mixing study results for the JT-71/72 tanks show that, for the cases modeled, the mixing time required for blending of the tank contents is no more than 35 minutes, which is well below 2.5more » hours of recirculation pump operation. Therefore, the results demonstrate the adequacy of 2.5 hours’ mixing time of the tank contents by one recirculation pump to get well mixed.« less

  4. Core transport properties in JT-60U and JET identity plasmas

    NASA Astrophysics Data System (ADS)

    Litaudon, X.; Sakamoto, Y.; de Vries, P. C.; Salmi, A.; Tala, T.; Angioni, C.; Benkadda, S.; Beurskens, M. N. A.; Bourdelle, C.; Brix, M.; Crombé, K.; Fujita, T.; Futatani, S.; Garbet, X.; Giroud, C.; Hawkes, N. C.; Hayashi, N.; Hoang, G. T.; Hogeweij, G. M. D.; Matsunaga, G.; Nakano, T.; Oyama, N.; Parail, V.; Shinohara, K.; Suzuki, T.; Takechi, M.; Takenaga, H.; Takizuka, T.; Urano, H.; Voitsekhovitch, I.; Yoshida, M.; ITPA Transport Group; JT-60 Team; EFDA contributors, JET

    2011-07-01

    The paper compares the transport properties of a set of dimensionless identity experiments performed between JET and JT-60U in the advanced tokamak regime with internal transport barrier, ITB. These International Tokamak Physics Activity, ITPA, joint experiments were carried out with the same plasma shape, toroidal magnetic field ripple and dimensionless profiles as close as possible during the ITB triggering phase in terms of safety factor, normalized Larmor radius, normalized collision frequency, thermal beta, ratio of ion to electron temperatures. Similarities in the ITB triggering mechanisms and sustainment were observed when a good match was achieved of the most relevant normalized profiles except the toroidal Mach number. Similar thermal ion transport levels in the two devices have been measured in either monotonic or non-monotonic q-profiles. In contrast, differences between JET and JT-60U were observed on the electron thermal and particle confinement in reversed magnetic shear configurations. It was found that the larger shear reversal in the very centre (inside normalized radius of 0.2) of JT-60U plasmas allowed the sustainment of stronger electron density ITBs compared with JET. As a consequence of peaked density profile, the core bootstrap current density is more than five times higher in JT-60U compared with JET. Thanks to the bootstrap effect and the slightly broader neutral beam deposition, reversed magnetic shear configurations are self-sustained in JT-60U scenarios. Analyses of similarities and differences between the two devices address key questions on the validity of the usual assumptions made in ITER steady scenario modelling, e.g. a flat density profile in the core with thermal transport barrier? Such assumptions have consequences on the prediction of fusion performance, bootstrap current and on the sustainment of the scenario.

  5. Adult Attachment Ratings (AAR): an item response theory analysis.

    PubMed

    Pilkonis, Paul A; Kim, Yookyung; Yu, Lan; Morse, Jennifer Q

    2014-01-01

    The Adult Attachment Ratings (AAR) include 3 scales for anxious, ambivalent attachment (excessive dependency, interpersonal ambivalence, and compulsive care-giving), 3 for avoidant attachment (rigid self-control, defensive separation, and emotional detachment), and 1 for secure attachment. The scales include items (ranging from 6-16 in their original form) scored by raters using a 3-point format (0 = absent, 1 = present, and 2 = strongly present) and summed to produce a total score. Item response theory (IRT) analyses were conducted with data from 414 participants recruited from psychiatric outpatient, medical, and community settings to identify the most informative items from each scale. The IRT results allowed us to shorten the scales to 5-item versions that are more precise and easier to rate because of their brevity. In general, the effective range of measurement for the scales was 0 to +2 SDs for each of the attachment constructs; that is, from average to high levels of attachment problems. Evidence for convergent and discriminant validity of the scales was investigated by comparing them with the Experiences of Close Relationships-Revised (ECR-R) scale and the Kobak Attachment Q-sort. The best consensus among self-reports on the ECR-R, informant ratings on the ECR-R, and expert judgments on the Q-sort and the AAR emerged for anxious, ambivalent attachment. Given the good psychometric characteristics of the scale for secure attachment, however, this measure alone might provide a simple alternative to more elaborate procedures for some measurement purposes. Conversion tables are provided for the 7 scales to facilitate transformation from raw scores to IRT-calibrated (theta) scores.

  6. DC-9 flight demonstration program with refanned JT8D engines. Volume 1: Summary

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The design, analysis, fabrication, and ground and flight testing of DC-9 airframe/nacelle hardware with prototype JT8D-109 engines are discussed. The installation of the JT8D-109 engine on the DC-9 Refan airplane required new or modified hardware for the pylon, nacelle, and fuselage. The acoustic material used in the nose cowl was bonded aluminum honeycomb sandwich and the exhaust duct acoustic material was Inconel 625 Stresskin. The sea level static, standard day bare engine takeoff thrust, the cruise TSFC and the maximum available cruise thrust for the JT8D-109 engine were compared with those of the JT8D-9 engine. The range capabilities of the DC-9 Refan and the production DC-9 airplane were also compared. The Refan airplane demonstrated flight characteristics similar to the production DC-9-30 and satisfied airworthiness requirements. Flyover noise levels were determined for the DC-9 Refan and the DC-9 C-9A airplane for takeoff and landing conditions. Cost estimates were also made.

  7. Diagnostic Accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex Scores in Predicting the Presence of Esophageal Varices in Liver Cirrhosis

    PubMed Central

    Deng, Han; Qi, Xingshun; Guo, Xiaozhong

    2015-01-01

    Abstract Aspartate aminotransferase-to-platelet ratio (APRI), aspartate aminotransferase-to-alanine aminotransferase ratio (AAR), FIB-4, FI, King, Lok, Forns, and FibroIndex scores may be simple and convenient noninvasive diagnostic tests, because they are based on the regular laboratory tests and demographic data. This study aimed to systematically evaluate their diagnostic accuracy for the prediction of varices in liver cirrhosis. All relevant papers were searched via PubMed, EMBASE, CNKI, and Wanfang databases. The area under the summary receiver operating characteristic curve (AUSROC), sensitivity, specificity, positive and negative likelihood ratio (PLR and NLR), and diagnostic odds ratio (DOR) were calculated. Overall, 12, 4, 5, 0, 0, 4, 3, and 1 paper was identified to explore the diagnostic accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex scores, respectively. The AUSROCs of APRI, AAR, FIB-4, Lok, and Forns scores for the prediction of varices were 0.6774, 0.7275, 0.7755, 0.7885, and 0.7517, respectively; and those for the prediction of large varices were 0.7278, 0.7448, 0.7095, 0.7264, and 0.6530, respectively. The diagnostic threshold effects of FIB-4 and Forns scores for the prediction of varices were statistically significant. The sensitivities/specificities/PLRs/NLRs/DORs of APRI, AAR, and Lok scores for the prediction of varices were 0.60/0.67/1.77/0.58/3.13, 0.64/0.63/1.97/0.54/4.18, and 0.74/0.68/2.34/0.40/5.76, respectively. The sensitivities/specificities/PLRs/NLRs/DORs of APRI, AAR, FIB-4, Lok, and Forns scores for the prediction of large varices were 0.65/0.66/2.15/0.47/4.97, 0.68/0.58/2.07/0.54/3.93, 0.62/0.64/2.02/0.56/3.57, 0.78/0.63/2.09/0.37/5.55, and 0.65/0.61/1.62/0.59/2.75, respectively. APRI, AAR, FIB-4, Lok, and Forns scores had low to moderate diagnostic accuracy in predicting the presence of varices in liver cirrhosis. PMID:26496312

  8. Analysis of JT-60SA operational scenarios

    NASA Astrophysics Data System (ADS)

    Garzotti, L.; Barbato, E.; Garcia, J.; Hayashi, N.; Voitsekhovitch, I.; Giruzzi, G.; Maget, P.; Romanelli, M.; Saarelma, S.; Stankiewitz, R.; Yoshida, M.; Zagórski, R.

    2018-02-01

    Reference scenarios for the JT-60SA tokamak have been simulated with one-dimensional transport codes to assess the stationary state of the flat-top phase and provide a profile database for further physics studies (e.g. MHD stability, gyrokinetic analysis) and diagnostics design. The types of scenario considered vary from pulsed standard H-mode to advanced non-inductive steady-state plasmas. In this paper we present the results obtained with the ASTRA, CRONOS, JINTRAC and TOPICS codes equipped with the Bohm/gyro-Bohm, CDBM and GLF23 transport models. The scenarios analysed here are: a standard ELMy H-mode, a hybrid scenario and a non-inductive steady state plasma, with operational parameters from the JT-60SA research plan. Several simulations of the scenarios under consideration have been performed with the above mentioned codes and transport models. The results from the different codes are in broad agreement and the main plasma parameters generally agree well with the zero dimensional estimates reported previously. The sensitivity of the results to different transport models and, in some cases, to the ELM/pedestal model has been investigated.

  9. Development of a cryogenic mixed fluid J-T cooling computer code, 'JTMIX'

    NASA Technical Reports Server (NTRS)

    Jones, Jack A.

    1991-01-01

    An initial study was performed for analyzing and predicting the temperatures and cooling capacities when mixtures of fluids are used in Joule-Thomson coolers and in heat pipes. A computer code, JTMIX, was developed for mixed gas J-T analysis for any fluid combination of neon, nitrogen, various hydrocarbons, argon, oxygen, carbon monoxide, carbon dioxide, and hydrogen sulfide. When used in conjunction with the NIST computer code, DDMIX, it has accurately predicted order-of-magnitude increases in J-T cooling capacities when various hydrocarbons are added to nitrogen, and it predicts nitrogen normal boiling point depressions to as low as 60 K when neon is added.

  10. Genotype/phenotype correlations in AARS-related neuropathy in a cohort of patients from the United Kingdom and Ireland.

    PubMed

    Bansagi, Boglarka; Antoniadi, Thalia; Burton-Jones, Sarah; Murphy, Sinead M; McHugh, John; Alexander, Michael; Wells, Richard; Davies, Joanna; Hilton-Jones, David; Lochmüller, Hanns; Chinnery, Patrick; Horvath, Rita

    2015-08-01

    Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy with heterogeneous clinical presentation and genetic background. The axonal form (CMT2) is characterised by decreased action potentials indicating primary axonal damage. The underlying pathology involves axonal degeneration which is supposed to be related to axonal protein dysfunction caused by various gene mutations. The overlapping clinical manifestation of CMT2 with distal hereditary motor neuropathy (dHMN) and intermediate CMT causes further diagnostic difficulties. Aminoacyl-tRNA synthetases have been implicated in the pathomechanism of CMT2. They have an essential role in protein translation by attaching amino acids to their cognate tRNAs. To date six families have been reported worldwide with dominant missense alanyl-tRNA synthetase (AARS) mutations leading to clinically heterogeneous axonal neuropathies. The pathomechanism of some variants could be explained by impaired amino acylation activity while other variants implicating an editing defect need to be further investigated. Here, we report a cohort of six additional families originating from the United Kingdom and Ireland with dominant AARS-related neuropathies. The phenotypic manifestation was distal lower limb predominant sensorimotor neuropathy but upper limb impairment with split hand deformity occasionally associated. Nerve conduction studies revealed significant demyelination accompanying the axonal lesion in motor and sensory nerves. Five families have the c.986G>A, p.(Arg329His) variant, further supporting that this is a recurrent loss of function variant. The sixth family, of Irish origin, had a novel missense variant, c.2063A>G, p.(Glu688Gly). We discuss our findings and the associated phenotypic heterogeneity in these families, which expands the clinical spectrum of AARS-related neuropathies.

  11. Use of after action reports (AARs) to promote organizational and systems learning in emergency preparedness.

    PubMed

    Savoia, Elena; Agboola, Foluso; Biddinger, Paul D

    2012-08-01

    Many public health and healthcare organizations use formal knowledge management practices to identify and disseminate the experiences gained over time. The "lessons-learned" approach is one such example of knowledge management practice applied to the wider concept of organizational learning. In the field of emergency preparedness, the lessons-learned approach stands on the assumption that learning from experience improves practice and minimizes avoidable deaths and negative economic and social consequences of disasters. In this project, we performed a structured review of AARs to analyze how lessons learned from the response to real-incidents may be used to maximize knowledge management and quality improvement practices such as the design of public health emergency preparedness (PHEP) exercises. We chose as a source of data the "Lessons Learned Information Sharing (LLIS.gov)" system, a joined program of the U.S. Department of Homeland Security DHS and FEMA that serves as the national, online repository of lessons learned, best practices, and innovative ideas. We identified recurring challenges reported by various states and local public health agencies in the response to different types of incidents. We also strove to identify the limitations of systematic learning that can be achieved due to existing weaknesses in the way AARs are developed.

  12. Use of After Action Reports (AARs) to Promote Organizational and Systems Learning in Emergency Preparedness

    PubMed Central

    Savoia, Elena; Agboola, Foluso; Biddinger, Paul D.

    2012-01-01

    Many public health and healthcare organizations use formal knowledge management practices to identify and disseminate the experiences gained over time. The “lessons-learned” approach is one such example of knowledge management practice applied to the wider concept of organizational learning. In the field of emergency preparedness, the lessons-learned approach stands on the assumption that learning from experience improves practice and minimizes avoidable deaths and negative economic and social consequences of disasters. In this project, we performed a structured review of AARs to analyze how lessons learned from the response to real-incidents may be used to maximize knowledge management and quality improvement practices such as the design of public health emergency preparedness (PHEP) exercises. We chose as a source of data the “Lessons Learned Information Sharing (LLIS.gov)” system, a joined program of the U.S. Department of Homeland Security DHS and FEMA that serves as the national, online repository of lessons learned, best practices, and innovative ideas. We identified recurring challenges reported by various states and local public health agencies in the response to different types of incidents. We also strived to identify the limitations of systematic learning that can be achieved due to existing weaknesses in the way AARs are developed. PMID:23066408

  13. A NASA F/A-18, participating in the Automated Aerial Refueling (AAR) project, flies over the Dryden

    NASA Technical Reports Server (NTRS)

    2002-01-01

    A NASA F/A-18 is participating in the Automated Aerial Refueling (AAR) project. The 300-gallon aerial refueling store seen on the belly of the aircraft carries fuel and a refueling drogue. This aircraft acts as a tanker in the study to develop an aerodynamic model for future automated aerial refueling, especially of unmanned vehicles.

  14. Phase 2 program on ground test of refanned JT8D turbofan engines and nacelles for the 727 airplane. Volume 3: Ground tests

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The NASA Refan Program included full-scale performance and noise ground tests of both a current production (JT8D-15) and a refanned (JT8D-115) engine. A description of the two ground tests including detailed propulsion, noise, and structural test results is presented. The primary objectives of the total test program were comparison of JT8D-15 and JT8D-115 overall propulsion system performance and noise characteristics and determination of incremental component noise levels. Other objectives of the test program included: (1) determination of acoustic treatment effectiveness; (2) measurement of internal sound pressure levels; (3) measurement of inlet and exhaust hardware performance; (4) determination of center-engine surge margin; and (5) evaluation of certain structural characteristics associated with the 727 refan center-engine inlet duct and JT8D refan engine exhaust system. The JT8D-15 and -115 tests were conducted during September 1974 and January to March 1975, respectively. Analyses of the test data indicated that the JT8D-115, as compared to the JT8D-15, demonstrates a 12.5 percent to 13.2 percent reduction in static specific fuel consumption, and a reduction of 6 to 7 PNdB in a weighted average value of static tone corrected perceived noise level. Separated into noise components, a significant reduction was shown for the inlet fan, aft fan, exhaust duct flow, turbine, and jet noises. However, core noise was increased. Photographs of test stands and test equipment are shown.

  15. Modelling of the test of the JT-60SA HTS current leads

    NASA Astrophysics Data System (ADS)

    Zappatore, A.; Heller, R.; Savoldi, L.; Zanino, R.

    2017-07-01

    The CURLEAD code, which was developed at the Karlsruhe Institute of Technology (KIT), implements an integrated 1D transient model of a high temperature superconducting (HTS) current lead (CL) including the room termination (RT), the meander-flow type heat exchanger (HX), and the HTS module. CURLEAD was successfully used for the design of the 70 kA ITER demonstrator and of the W7-X and JT-60SA CLs. Recently the code was successfully applied to the prediction and analysis of steady state operation of the ITER correction coils (CC) HTS CL. Here the steady state and pulsed operation of the JT-60SA HTS CLs are analysed, which requires also the modelling of the HX shell and of the vacuum shell, which was not present in the ITER CC. The CURLEAD model extension is presented and the capability of the new version of CURLEAD to reproduce the transient experimental data of the JT-60SA HTS CL is shown. The results obtained provide a better understanding of key parameters of the CL, among which the temperature evolution at the HX-HTS interface, the GHe mass flow rate needed in the HX to achieve the target temperature at that location and the heat load at the cold end.

  16. Design Status of the Cryogenic System and Operation Modes Analysys of the JT-60SA Tokamak

    NASA Astrophysics Data System (ADS)

    Roussel, P.; Hoa, C.; Lamaison, V.; Michel, F.; Reynaud, P.; Wanner, M.

    2010-04-01

    The JT-60SA project is part of the Broader Approach Programme signed between Japan and Europe. This superconducting upgrade of the existing JT-60U tokamak in Naka, Japan shall start operation in 2016 and shall support ITER exploitation and research towards DEMO fusion reactor. JT-60SA is currently in the basic design phase. The cryogenic system of JT-60SA shall provide supercritical helium to cool the superconducting magnets and their structures at 4.4 K, and the divertor cryopumps at a temperature of 3.7 K. In addition it shall provide refrigeration for the thermal shields at 80 K and deliver helium at 50 K for the current leads. The equivalent refrigeration capacity at 4.5 K will be about 10 kW. The refrigeration process has to be optimised for different operation modes. During the day, in plasma operation state, the refrigerator will cope with the pulsed heat loads which may increase up to 100% of the average power, representing a big challenge compared to other tokamaks. Fast discharge quenches of the magnets, the impact from baking of the vacuum vessel, cool down and warm up modes are presented from the cryogenic system point of view and their impact on the cryogenic design is described.

  17. Diagnostic Accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex Scores in Predicting the Presence of Esophageal Varices in Liver Cirrhosis: A Systematic Review and Meta-Analysis.

    PubMed

    Deng, Han; Qi, Xingshun; Guo, Xiaozhong

    2015-10-01

    Aspartate aminotransferase-to-platelet ratio (APRI), aspartate aminotransferase-to-alanine aminotransferase ratio (AAR), FIB-4, FI, King, Lok, Forns, and FibroIndex scores may be simple and convenient noninvasive diagnostic tests, because they are based on the regular laboratory tests and demographic data. This study aimed to systematically evaluate their diagnostic accuracy for the prediction of varices in liver cirrhosis.All relevant papers were searched via PubMed, EMBASE, CNKI, and Wanfang databases. The area under the summary receiver operating characteristic curve (AUSROC), sensitivity, specificity, positive and negative likelihood ratio (PLR and NLR), and diagnostic odds ratio (DOR) were calculated.Overall, 12, 4, 5, 0, 0, 4, 3, and 1 paper was identified to explore the diagnostic accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex scores, respectively. The AUSROCs of APRI, AAR, FIB-4, Lok, and Forns scores for the prediction of varices were 0.6774, 0.7275, 0.7755, 0.7885, and 0.7517, respectively; and those for the prediction of large varices were 0.7278, 0.7448, 0.7095, 0.7264, and 0.6530, respectively. The diagnostic threshold effects of FIB-4 and Forns scores for the prediction of varices were statistically significant. The sensitivities/specificities/PLRs/NLRs/DORs of APRI, AAR, and Lok scores for the prediction of varices were 0.60/0.67/1.77/0.58/3.13, 0.64/0.63/1.97/0.54/4.18, and 0.74/0.68/2.34/0.40/5.76, respectively. The sensitivities/specificities/PLRs/NLRs/DORs of APRI, AAR, FIB-4, Lok, and Forns scores for the prediction of large varices were 0.65/0.66/2.15/0.47/4.97, 0.68/0.58/2.07/0.54/3.93, 0.62/0.64/2.02/0.56/3.57, 0.78/0.63/2.09/0.37/5.55, and 0.65/0.61/1.62/0.59/2.75, respectively.APRI, AAR, FIB-4, Lok, and Forns scores had low to moderate diagnostic accuracy in predicting the presence of varices in liver cirrhosis.

  18. The new technological solution for the JT-60SA quench protection circuits

    NASA Astrophysics Data System (ADS)

    Gaio, E.; Maistrello, A.; Novello, L.; Matsukawa, M.; Perna, M.; Ferro, A.; Yamauchi, K.; Piovan, R.

    2018-07-01

    An advanced technology has been developed and employed for the main circuit breakers (CB) of the quench protection circuits (QPC) of the superconducting coils of JT-60SA: it consists in a Hybrid mechanical-static CB (HCB) composed of a mechanical Bypass switch (BPS) for conducting the continuous current, in parallel to a static circuit breaker (SCB) based on integrated gate commutated thyristor (IGCT) for current interruption. It was the result of a R&D program carried out since 2006 to identify innovative solutions for the interruption of high dc current, able to improve the maintainability and availability of the CB. The HCB developed for the JT-60SA QPC is the first realization of a dc circuit breaker based on this design approach for interrupting current of some tens of kA with reapplied voltage of some kV. It also represents the first application of hybrid technology with IGCT for protection of superconducting magnets in fusion experiments. The paper aims at giving a comprehensive overview of the main R&D activities devoted to the development of this new technological approach; then, the key aspects of the design, manufacturing and testing of the QPCs for JT-60SA, successfully completed in Naka Site in summer 2015 are presented. Finally, the significance of this research is discussed and the possible future developments, in particular in view of DEMO fusion reactor, are outlined.

  19. 76 FR 41144 - Airworthiness Directives; Pratt & Whitney Corp. (PW) JT9D-7R4H1 Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ...-7R4H1 turbofan engines. This proposed AD would require removing certain high-pressure compressor (HPC...) Applicability Pratt & Whitney Corp (PW) JT9D-7R4H1 turbofan engines with a high-pressure compressor (HPC) shaft... the rear shaft. These engines have the highest-thrust rating of the JT9D models, and were operating in...

  20. Physics and operation oriented activities in preparation of the JT-60SA tokamak exploitation

    NASA Astrophysics Data System (ADS)

    Giruzzi, G.; Yoshida, M.; Artaud, J. F.; Asztalos, Ö.; Barbato, E.; Bettini, P.; Bierwage, A.; Boboc, A.; Bolzonella, T.; Clement-Lorenzo, S.; Coda, S.; Cruz, N.; Day, Chr.; De Tommasi, G.; Dibon, M.; Douai, D.; Dunai, D.; Enoeda, M.; Farina, D.; Figini, L.; Fukumoto, M.; Galazka, K.; Galdon, J.; Garcia, J.; Garcia-Muñoz, M.; Garzotti, L.; Gil, C.; Gleason-Gonzalez, C.; Goodman, T.; Granucci, G.; Hayashi, N.; Hoshino, K.; Ide, S.; Imazawa, R.; Innocente, P.; Isayama, A.; Itami, K.; Joffrin, E.; Kamada, Y.; Kamiya, K.; Kawano, Y.; Kawashima, H.; Kobayashi, T.; Kojima, A.; Kubo, H.; Lang, P.; Lauber, Ph.; de la Luna, E.; Maget, P.; Marchiori, G.; Mastrostefano, S.; Matsunaga, G.; Mattei, M.; McDonald, D. C.; Mele, A.; Miyata, Y.; Moriyama, S.; Moro, A.; Nakano, T.; Neu, R.; Nowak, S.; Orsitto, F. P.; Pautasso, G.; Pégourié, B.; Pigatto, L.; Pironti, A.; Platania, P.; Pokol, G. I.; Ricci, D.; Romanelli, M.; Saarelma, S.; Sakurai, S.; Sartori, F.; Sasao, H.; Scannapiego, M.; Shimizu, K.; Shinohara, K.; Shiraishi, J.; Soare, S.; Sozzi, C.; Stępniewski, W.; Suzuki, T.; Suzuki, Y.; Szepesi, T.; Takechi, M.; Tanaka, K.; Terranova, D.; Toma, M.; Urano, H.; Vega, J.; Villone, F.; Vitale, V.; Wakatsuki, T.; Wischmeier, M.; Zagórski, R.

    2017-08-01

    The JT-60SA tokamak, being built under the Broader Approach agreement jointly by Europe and Japan, is due to start operation in 2020 and is expected to give substantial contributions to both ITER and DEMO scenario optimisation. A broad set of preparation activities for an efficient start of the experiments on JT-60SA is being carried out, involving elaboration of the Research Plan, advanced modelling in various domains, feasibility and conception studies of diagnostics and other sub-systems in connection with the priorities of the scientific programme, development and validation of operation tools. The logic and coherence of this approach, as well as the most significant results of the main activities undertaken are presented and summarised.

  1. Development of a J-T Micro Compressor

    NASA Astrophysics Data System (ADS)

    Champagne, P.; Olson, J. R.; Nast, T.; Roth, E.; Collaco, A.; Kaldas, G.; Saito, E.; Loung, V.

    2015-12-01

    Lockheed Martin has developed and tested a space-quality compressor capable of delivering closed-loop gas flow with a high pressure ratio, suitable for driving a Joule- Thomson cold head. The compressor is based on a traditional “Oxford style” dual-opposed piston compressor with linear drive motors and flexure-bearing clearance-seal technology for high reliability and long life. This J-T compressor retains the approximate size, weight, and cost of the ultra-compact, 200 gram Lockheed Martin Pulse Tube Micro Compressor, despite the addition of a flow-rectifying system to convert the AC pressure wave into a steady flow.

  2. FibroScan, aspartate aminotransferase and alanine aminotransferase ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factor (FIB-4), and their combinations in the assessment of liver fibrosis in patients with hepatitis B.

    PubMed

    Ding, Deping; Li, Hongbing; Liu, Ping; Chen, Lingli; Kang, Jian; Zhang, Yinhua; Ma, Deqiang; Chen, Yue; Luo, Jie; Meng, Zhongji

    2015-01-01

    The aim of this study was to assess the effects of FibroScan, aspartate aminotransferase and alanine aminotransferase ratio (AAR), aspartate aminotransferase to platelet ratio index (APRI), fibrosis index based on the 4 factor (FIB-4) and their combinations on liver fibrosis in patients with hepatitis B. 406 hospitalized patients with chronic hepatitis B (CHB) and cirrhosis in our hospital were analyzed retrospectively and collected patients clinical indicators, including liver stiffness (LS), AAR, APRI and FIB-4, and then compared the differences of these indicators between CHB group and hepatitis B with cirrhosis group. Receiver operating curve (ROC) was used to evaluate the differentiating capacity of these indicators on CHB and liver cirrhosis. Four indicators related to liver cirrhosis had a statistical significance between two groups (P < 0.01); the under ROC curve areas of LS, AAR, APRI and FIB-4 for differential diagnosis of CHB and liver cirrhosis were 0.866, 0.772, 0.632 and 0.885, respectively. The under ROC curve areas of LS, AAR, APRI and FIB-4 for differential diagnosis of liver cirrhosis at compensatory stage and de-compensatory stage were 0.627, 0.666, 0.795 and 0.820, respectively. LS, AAR, APRI and FIB-4 were good indicators as clinical diagnosis and differential diagnosis on hepatitis B related cirrhosis.

  3. The 727/JT8D refan side nacelle airloads

    NASA Technical Reports Server (NTRS)

    Bailey, R. W.; Vadset, H. J.

    1974-01-01

    Airloads on the 727/JT8D refan side engine nacelle are presented. These consist of surface static pressure distributions from two low speed wind tunnel tests. External nacelle surface pressures are from testing of a flow-through, body mounted nacelle model, and internal inlet surface pressures are from performance testing of a forced air inlet model. The method for obtaining critical airloads on nacelle components and a representative example are discussed.

  4. Engine component improvement: Performance improvement, JT9D-7 3.8 AR fan

    NASA Technical Reports Server (NTRS)

    Gaffin, W. O.

    1980-01-01

    A redesigned, fuel efficient fan for the JT9D-7 engine was tested. Tests were conducted to determine the effect of the 3.8 AR fan on performance, stability, operational characteristics, and noise of the JT9D-7 engine relative to the current 4.6 AR Bill-of-Material fan. The 3.8 AR fan provides increased fan efficiency due to a more advanced blade airfoil with increased chord, eliminating one part span shroud and reducing the number of fan blades and fan exit guide vanes. Engine testing at simulated cruise conditions demonstrated the predicted 1.3 percent improvement in specific fuel consumption with the redesigned 3.8 AR fan. Flight testing and sea level stand engine testing demonstrated exhaust gas temperature margins, fan and low pressure compressor stability, operational suitability, and noise levels comparable to the Bill-of-Material fan.

  5. Lake Biel Holocene sediment record before and after the Aare river deviation (1878 AD)

    NASA Astrophysics Data System (ADS)

    Jeannet, Alice; Corella, Juan Pablo; Kremer, Katrina; Girardclos, Stéphanie

    2014-05-01

    Lake sediments are excellent archives of environmental and climate changes as well as human impact on lake- and river-systems. Lake Biel is a medium-sized peri-alpine lake in Switzerland, with a maximum depth of 74 m, and lies at an altitude of 429 m a.s.l. Lake Biel, which formed during the Pleistocene by glacial erosion, is part of the Aare river system. Our study focuses on the south-west part of the lake basin where the lake sedimentation was originally (i.e. naturally) mainly controlled by autochthonous sedimentation. This area is currently under a strong influence of water and sediment input from this river catchment since the Aare river deviation through the Hagneck canal in 1878. A 10.05 m long composite sediment sequence, cored from a 52 m water depth in September 2011, was built from two long cores retrieved with the ETH Zurich/Eawag Uwitec system. A radiocarbon age model indicates that the retrieved sedimentary sequence spans the last 7500 years. The upper sediments were correlated to previous short core radionuclide stratigraphy for the 1.5 m upper part (Thevenon et al., 2013). Magnetic susceptibility and density were measured by Geotek MultiSensor Core Logger at 0.5 cm resolution. Granulometry was measured with a CILAS grain sizer every 10 cm, and X-ray fluorescence (XRF) was carried out using an Avaatech core scanner at 1-cm resolution. This technique provides semi-quantitative information of the sediment elemental composition and shows how runoff and river input (Ti, Al, Si) or redox conditions (Fe/Mn) vary through time. Lake Biel sediment record suggests marked environmental changes with runoff decrease linked to climate and vegetation change during Atlantic chronobiozone, as well as a complex climate-human impact during the 'La Tène' and Roman cultural times. The most prominent recorded feature is the 10-times increase of sediment rate that occurred after the Aare river deviation through the Hagneck canal into Lake Biel in 1878. This artificial

  6. JT90 Ceramic Outer Air Seal System Refinement Program, Phase 2

    NASA Technical Reports Server (NTRS)

    Shiembob, L. T.

    1982-01-01

    The sprayed ceramic gas turbine outer air seal system was tested in two JT9D engines to substantiate the abradability and durability of the seals. Of particular significance was that one of the tests, a 150 hour 1000 cycle endurance program at nominal JT9D operating conditions, was completed with minimal effect on the seals and received Federal Aviation Administration cognizance with respect to potential field service use by the airlines. The other engine test completed 1825 endurance cycles at severe operating conditions and no burn through or other serious defects in the structural integrity of a seal segment was observed. These test results combined with other Pratt and Whitney Aircraft engine tests substantiate the potential of the ceramic outer air seal system to attain the durability goal of 50000 hour engine operating capability. Both engine tests subjected the seals to intentional blade rubs and demonstrated good abradability with volume wear ratios greater than 100, far exceeding the design goal of 10. The improved volume wear ratio will allow the turbine tip clearance to be reduced, thereby resulting in an estimated thrust specific fuel consumption improvement of 0.3 percent.

  7. JT9D engine diagnostics. Task 2: Feasibility study of measuring in-service flight loads. [747 aircraft performance

    NASA Technical Reports Server (NTRS)

    Kafka, P. G.; Skibo, M. A.; White, J. L.

    1977-01-01

    The feasibility of measuring JT9D propulsion system flight inertia loads on a 747 airplane is studied. Flight loads background is discussed including the current status of 747/JT9D loads knowledge. An instrumentation and test plan is formulated for an airline-owned in-service airplane and the Boeing-owned RA001 test airplane. Technical and cost comparisons are made between these two options. An overall technical feasibility evaluation is made and a cost summary presented. Conclusions and recommendations are presented in regard to using existing inertia loads data versus conducting a flight test to measure inertia loads.

  8. JT9D ceramic outer air seal system refinement program

    NASA Technical Reports Server (NTRS)

    Gaffin, W. O.

    1982-01-01

    The abradability and durability characteristics of the plasma sprayed system were improved by refinement and optimization of the plasma spray process and the metal substrate design. The acceptability of the final seal system for engine testing was demonstrated by an extensive rig test program which included thermal shock tolerance, thermal gradient, thermal cycle, erosion, and abradability tests. An interim seal system design was also subjected to 2500 endurance test cycles in a JT9D-7 engine.

  9. This NASA Dryden F/A-18 is participating in the Automated Aerial Refueling (AAR) project. F/A-18 (No

    NASA Technical Reports Server (NTRS)

    2002-01-01

    A NASA Dryden F/A-18 is participating in the Automated Aerial Refueling (AAR) project. F/A-18 (No. 847) is acting as an in-flight refueling tanker in the study to develop analytical models for an automated aerial refueling system for unmanned vehicles. A 300-gallon aerodynamic pod containing air-refueling equipment is seen beneath the fuselage. The hose and refueling basket are extended during an assessment of their dynamics on the F/A-18A.

  10. Modelling and Model-Based-Designed PID Control of the JT-60SA Cryogenic System Using the Simcryogenics Library

    NASA Astrophysics Data System (ADS)

    Bonne, F.; Bonnay, P.; Hoa, C.; Mahoudeau, G.; Rousset, B.

    2017-02-01

    This papers deals with the Japan Torus-60 Super Advanced fusion experiment JT-60SA cryogenic system. A presentation of the JT-60SA cryogenic system model, from 300K to 4.4K -using the Matlab/Simulink/Simscape Simcryogenics library- will be given. As a first validation of our modelling strategy, the obtained operating point will be compared with the one obtained from HYSYS simulations. In the JT60-SA tokamak, pulsed heat loads are expected to be coming from the plasma and must be handled properly, using both appropriate refrigerator architecture and appropriate control model, to smooth the heat load. This paper presents model-based designed PID control schemes to control the helium mass inside the phase separator. The helium mass inside the phase separator as been chosen to be the variable of interest in the phase separator since it is independent of the pressure which can vary from 1 bar to 1.8 bar during load smoothing. Dynamics simulations will be shown to assess the legitimacy of the proposed strategy. This work is partially supported through the French National Research Agency (ANR), task agreement ANR-13-SEED-0005.

  11. Dynamic simulations for preparing the acceptance test of JT-60SA cryogenic system

    NASA Astrophysics Data System (ADS)

    Cirillo, R.; Hoa, C.; Michel, F.; Poncet, J. M.; Rousset, B.

    2016-12-01

    Power generation in the future could be provided by thermo-nuclear fusion reactors like tokamaks. There inside, the fusion reaction takes place thanks to the generation of plasmas at hundreds of millions of degrees that must be confined magnetically with superconductive coils, cooled down to around 4.5 K. Within this frame, an experimental tokamak device, JT-60SA is currently under construction in Naka (Japan). The plasma works cyclically and the coil system is subject to pulsed heat loads. In order to size the refrigerator close to the average power and hence optimizing investment and operational costs, measures have to be taken to smooth the heat load. Here we present a dynamic model of the JT-60SA's Auxiliary Cold box (ACB) for preparing the acceptance tests of the refrigeration system planned in 2016 in Naka. The aim of this study is to simulate the pulsed load scenarios using different process controls. All the simulations have been performed with EcosimPro® and the associated cryogenic library: CRYOLIB.

  12. Achievement and improvement of the JT-60U negative ion source for JT-60 Super Advanced (invited)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kojima, A.; Hanada, M.; Tanaka, Y.

    2010-02-15

    Developments of the large negative ion source have been progressed in the high-energy, high-power, and long-pulse neutral beam injector for JT-60 Super Advanced. Countermeasures have been studied and tested for critical issues of grid heat load and voltage holding capability. As for the heat load of the acceleration grids, direct interception of D{sup -} ions was reduced by adjusting the beamlet steering. As a result, the heat load was reduced below an allowable level for long-pulse injections. As for the voltage holding capability, local electric field was mitigated by tuning gap lengths between large-area acceleration grids in the accelerator. Asmore » a result, the voltage holding capability was improved up to the rated value of 500 kV. To investigate the voltage holding capability during beam acceleration, the beam acceleration test is ongoing with new extended gap.« less

  13. Improvement of voltage holding capability in the 500 keV negative ion source for JT-60SA.

    PubMed

    Tanaka, Y; Hanada, M; Kojima, A; Akino, N; Shimizu, T; Ohshima, K; Inoue, T; Watanabe, K; Taniguchi, M; Kashiwagi, M; Umeda, N; Tobari, H; Grisham, L R

    2010-02-01

    Voltage holding capability of JT-60 negative ion source that has a large electrostatic negative ion accelerator with 45 cm x 1.1 m acceleration grids was experimentally examined and improved to realize 500 keV, 22 A, and 100 s D- ion beams for JT-60 Super Advanced. The gap lengths in the acceleration stages were extended to reduce electric fields in a gap between the large grids and at the corner of the support flanges from the original 4-5 to 3-4 kV/mm. As a result, the voltage holding capability without beam acceleration has been successfully improved from 400 to 500 kV. The pulse duration to hold 500 kV reached 40 s of the power supply limitation.

  14. Improvement of voltage holding capability in the 500 keV negative ion source for JT-60SA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tanaka, Y.; Hanada, M.; Kojima, A.

    2010-02-15

    Voltage holding capability of JT-60 negative ion source that has a large electrostatic negative ion accelerator with 45 cmx1.1 m acceleration grids was experimentally examined and improved to realize 500 keV, 22 A, and 100 s D{sup -} ion beams for JT-60 Super Advanced. The gap lengths in the acceleration stages were extended to reduce electric fields in a gap between the large grids and at the corner of the support flanges from the original 4-5 to 3-4 kV/mm. As a result, the voltage holding capability without beam acceleration has been successfully improved from 400 to 500 kV. The pulsemore » duration to hold 500 kV reached 40 s of the power supply limitation.« less

  15. JT9D performance deterioration results from a simulated aerodynamic load test

    NASA Technical Reports Server (NTRS)

    Stakolich, E. G.; Stromberg, W. J.

    1981-01-01

    The results of testing to identify the effects of simulated aerodynamic flight loads on JT9D engine performance are presented. The test results were also used to refine previous analytical studies on the impact of aerodynamic flight loads on performance losses. To accomplish these objectives, a JT9D-7AH engine was assembled with average production clearances and new seals as well as extensive instrumentation to monitor engine performance, case temperatures, and blade tip clearance changes. A special loading device was designed and constructed to permit application of known moments and shear forces to the engine by the use of cables placed around the flight inlet. The test was conducted in the Pratt & Whitney Aircraft X-Ray Test Facility to permit the use of X-ray techniques in conjunction with laser blade tip proximity probes to monitor important engine clearance changes. Upon completion of the test program, the test engine was disassembled, and the condition of gas path parts and final clearances were documented. The test results indicate that the engine lost 1.1 percent in thrust specific fuel consumption (TSFC), as measured under sea level static conditions, due to increased operating clearances caused by simulated flight loads. This compares with 0.9 percent predicted by the analytical model and previous study efforts.

  16. Finite element-integral simulation of static and flight fan noise radiation from the JT15D turbofan engine

    NASA Technical Reports Server (NTRS)

    Baumeister, K. J.; Horowitz, S. J.

    1982-01-01

    An iterative finite element integral technique is used to predict the sound field radiated from the JT15D turbofan inlet. The sound field is divided into two regions: the sound field within and near the inlet which is computed using the finite element method and the radiation field beyond the inlet which is calculated using an integral solution technique. The velocity potential formulation of the acoustic wave equation was employed in the program. For some single mode JT15D data, the theory and experiment are in good agreement for the far field radiation pattern as well as suppressor attenuation. Also, the computer program is used to simulate flight effects that cannot be performed on a ground static test stand.

  17. A 727 airplane center duct inlet low speed performance confirmation model test for refanned JT8D engines, phase 2

    NASA Technical Reports Server (NTRS)

    Kaldschmidt, G.; Syltebo, B. E.; Ting, C. T.

    1973-01-01

    The results from testing of a 0.3 scale model center duct inlet (S duct) for the Pratt and Whitney Aircraft JT8D-100 engines are presented. The objective of this test was to demonstrate that the required airflow of the JT8D-100 engine (480 lb/sec as compared to 334 lb/sec for JT8D-15) can be achieved with minimum modifications to the existing 727 airplane structure at acceptable levels of total pressure recovery and distortion. Steady-state pressure recovery, steady-state pressure distortion, and dynamic pressure measurements were taken at the engine face station. Surface static pressure measurements were taken along the duct. Test results indicated that the required airflow was achieved with acceptable pressure recovery (comparable to the current 727-200 S duct). Inlet inflow angle variation within the 727 airplane operating regime (minus 5 to 5 degrees) had no effect on the inlet performance. Pressure distortion at static and forward speed at takeoff airflow conditions are within P and WA limits for the Phase II duct when equipped with vortex generators. Static crosswind operation between 10 knots and 25 knots appears feasible at full takeoff power.

  18. Advanced tokamak research with integrated modeling in JT-60 Upgrade

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hayashi, N.

    2010-05-15

    Researches on advanced tokamak (AT) have progressed with integrated modeling in JT-60 Upgrade [N. Oyama et al., Nucl. Fusion 49, 104007 (2009)]. Based on JT-60U experimental analyses and first principle simulations, new models were developed and integrated into core, rotation, edge/pedestal, and scrape-off-layer (SOL)/divertor codes. The integrated models clarified complex and autonomous features in AT. An integrated core model was implemented to take account of an anomalous radial transport of alpha particles caused by Alfven eigenmodes. It showed the reduction in the fusion gain by the anomalous radial transport and further escape of alpha particles. Integrated rotation model showed mechanismsmore » of rotation driven by the magnetic-field-ripple loss of fast ions and the charge separation due to fast-ion drift. An inward pinch model of high-Z impurity due to the atomic process was developed and indicated that the pinch velocity increases with the toroidal rotation. Integrated edge/pedestal model clarified causes of collisionality dependence of energy loss due to the edge localized mode and the enhancement of energy loss by steepening a core pressure gradient just inside the pedestal top. An ideal magnetohydrodynamics stability code was developed to take account of toroidal rotation and clarified a destabilizing effect of rotation on the pedestal. Integrated SOL/divertor model clarified a mechanism of X-point multifaceted asymmetric radiation from edge. A model of the SOL flow driven by core particle orbits which partially enter the SOL was developed by introducing the ion-orbit-induced flow to fluid equations.« less

  19. High-beta steady-state research with integrated modeling in the JT-60 Upgrade

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ozeki, T.

    2007-05-15

    Improvement of high-beta performance and its long sustainment was obtained with ferritic steel tiles in the JT-60 Upgrade (JT-60U) [T. Fujita et al., Phys. Plasmas 50, 104 (2005)], which were installed inside the vacuum vessel to reduce fast ion loss by decreasing the toroidal field ripple. When a separation between the plasma surface and the wall was small, high-beta plasmas reached the ideal wall stability limit, i.e., the ideal magnetohydrodynamics stability limit with the wall stabilization. A small rotation velocity of 0.3% of the Alfven velocity was found to be effective for suppressing the resistive wall mode. Sustainment of themore » high normalized beta value of {beta}{sub N}=2.3 has been extended to 28.6 s ({approx}15 times the current diffusion time) by improvement of the confinement and increase in the net heating power. Based on the research in JT-60U experiments and first-principle simulations, integrated models of core, edge-pedestal, and scrape-off-layer (SOL) divertors were developed, and they clarified complex features of reactor-relevant plasmas. The integrated core plasma model indicated that the small amount of electron cyclotron (EC) current density of about half the bootstrap current density could effectively stabilize the neoclassical tearing mode by the localized EC current accurately aligned to the magnetic island center. The integrated edge-pedestal model clarified that the collisionality dependence of energy loss due to the edge-localized mode was caused by the change in the width of the unstable mode and the SOL transport. The integrated SOL-divertor model clarified the effect of the exhaust slot on the pumping efficiency and the cause of enhanced radiation near the X-point multifaceted asymmetric radiation from edge. Success in these consistent analyses using the integrated code indicates that it is an effective means to investigate complex plasmas and to control the integrated performance.« less

  20. Feasibility of a far infrared laser based polarimeter diagnostic system for the JT-60SA fusion experiment

    NASA Astrophysics Data System (ADS)

    Boboc, A.; Gil, C.; Terranova, D.; Orsitto, F. P.; Soare, S.; Lotte, P.; Sozzi, C.; Imazawa, R.; Kubo, H.

    2018-07-01

    JT-60SA is the large Tokamak device that is being built in Japan under the Broader Approach Satellite Tokamak Programme and the Japanese National Programme and will operate as a satellite machine for ITER. The main goal of the JT-60SA Programme is to provide valuable information for the ITER steady-state scenario and for the design of DEMO, where the real-time control of the safety factor profile is very important, in connection with both MHD stability and plasma confinement. It has been demonstrated in this work that to this end polarimetry measurements are necessary, in particular in order to reconstruct the safety factor profile in reversed shear scenarios. In this paper we present the main steps of a conceptual feasibility study of a multi-channel polarimeter diagnostic and the resulting optimised geometry. In this study, magnetic scenario modelling, a realistic CAD-driven design and long-term operation requirements, rarely even considered at this stage, have been considered. It is shown that a far infrared polarimeter system, with a laser operating at a wavelength of 194.7 μm and up to twelve channels can be envisaged for JT-60SA. The top requirements can be attained, i.e., that the polarimeter, together with other diagnostic measurements, should provide q-profile reconstruction with an accuracy of 10% for the entire plasma cycle and suitable time resolution for real-time applications, in particular in high density and ITER-relevant plasma scenarios.

  1. Assessment of the accuracy of plasma shape reconstruction by the Cauchy condition surface method in JT-60SA

    NASA Astrophysics Data System (ADS)

    Miyata, Y.; Suzuki, T.; Takechi, M.; Urano, H.; Ide, S.

    2015-07-01

    For the purpose of stable plasma equilibrium control and detailed analysis, it is essential to reconstruct an accurate plasma boundary on the poloidal cross section in tokamak devices. The Cauchy condition surface (CCS) method is a numerical approach for calculating the spatial distribution of the magnetic flux outside a hypothetical surface and reconstructing the plasma boundary from the magnetic measurements located outside the plasma. The accuracy of the plasma shape reconstruction has been assessed by comparing the CCS method and an equilibrium calculation in JT-60SA with a high elongation and triangularity of plasma shape. The CCS, on which both Dirichlet and Neumann conditions are unknown, is defined as a hypothetical surface located inside the real plasma region. The accuracy of the plasma shape reconstruction is sensitive to the CCS free parameters such as the number of unknown parameters and the shape in JT-60SA. It is found that the optimum number of unknown parameters and the size of the CCS that minimizes errors in the reconstructed plasma shape are in proportion to the plasma size. Furthermore, it is shown that the accuracy of the plasma shape reconstruction is greatly improved using the optimum number of unknown parameters and shape of the CCS, and the reachable reconstruction errors in plasma shape and locations of strike points are within the target ranges in JT-60SA.

  2. DC-9 flight demonstration program with refanned JT8D engines. Volume 4: Flyover noise

    NASA Technical Reports Server (NTRS)

    1975-01-01

    Flyover noise tests were conducted to determine the noise reductions achievable by modifying the engines and nacelles of DC-9-30 airplanes. The two stage fan of the JT8D-9 engine was replaced with a larger diameter, single stage fan and sound absorbing materials were incorporated in the engines and nacelles. The noise levels were determined to be 95.3 EPNdB at the sideline, 96.2 EPNdB for a full thrust takeoff, 87.5 EPNdB for takeoff with thrust cutback, and 97.4 EPNdB for landing approach. The noise reductions relative to the hardwall JT8D-9 were 8.2 EPNdB for takeoff with cutback and 8.7 EPNdB for landing. The 90 EPNdB noise contour areas were reduced by 40% for missions requiring maximum design takeoff and landing weights. For typical mission weights, the reductions were 19% for full thrust takeoff and 34% for takeoff with cutback. The 95 EPNdB contour areas were reduced by 50% for takeoff and 30% for takeoff with cutback for both missions.

  3. Predictive modelling of JT-60SA high-beta steady-state plasma with impurity accumulation

    NASA Astrophysics Data System (ADS)

    Hayashi, N.; Hoshino, K.; Honda, M.; Ide, S.

    2018-06-01

    The integrated modelling code TOPICS has been extended to include core impurity transport, and applied to predictive modelling of JT-60SA high-beta steady-state plasma with the accumulation of impurity seeded to reduce the divertor heat load. In the modelling, models and conditions are selected for a conservative prediction, which considers a lower bound of plasma performance with the maximum accumulation of impurity. The conservative prediction shows the compatibility of impurity seeding with core plasma with high-beta (β N  >  3.5) and full current drive conditions, i.e. when Ar seeding reduces the divertor heat load below 10 MW m‑2, its accumulation in the core is so moderate that the core plasma performance can be recovered by additional heating within the machine capability to compensate for Ar radiation. Due to the strong dependence of accumulation on the pedestal density gradient, high separatrix density is important for the low accumulation as well as the low divertor heat load. The conservative prediction also shows that JT-60SA has enough capability to explore the divertor heat load control by impurity seeding in high-beta steady-state plasmas.

  4. Development of Fast Measurement System of Neutron Emission Profile Using a Digital Signal Processing Technique in JT-60U

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ishikawa, M.; Shinohara, K.; Itoga, T.

    2008-03-12

    Neutron emission profiles are routinely measured in JT-60U Tokamak. Stinbene neuron detectors (SNDs), which combine a Stilbene organic crystal scintillation detector (Stilbene detector) with an analog neutron-gamma pulse shape discrimination (PSD) circuit, have been used to measure neutron flux efficiently. Although the SND has many advantages as a neutron detector, the maximum count rate is limited up to {approx}1x 10{sup 5} counts/s due to the dead time of the analog PSD circuit. To overcome this issue, a digital signal processing (DSP) system using a Flash-ADC has been developed. In this system, anode signals from the photomultiplier of the Stilbene detectormore » are fed to the Flash ADC and digitized. Then, the PSD between neutrons and gamma-rays are performed using software. The photomultiplier tube is also modified to suppress and correct gain fluctuation of the photomultiplier. The DSP system has been installed in the center channel of the vertical neutron collimator system in JT-60U and applied to measurements of neutron flux in JT-60U experiments. Neutron flux are successfully measured with count rate up to {approx}1x 10{sup 6} counts/s without the effect of pile up of detected pulses. The performance of the DSP system as a neutron detector is demonstrated.« less

  5. Assessment of the accuracy of plasma shape reconstruction by the Cauchy condition surface method in JT-60SA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miyata, Y.; Suzuki, T.; Takechi, M.

    2015-07-15

    For the purpose of stable plasma equilibrium control and detailed analysis, it is essential to reconstruct an accurate plasma boundary on the poloidal cross section in tokamak devices. The Cauchy condition surface (CCS) method is a numerical approach for calculating the spatial distribution of the magnetic flux outside a hypothetical surface and reconstructing the plasma boundary from the magnetic measurements located outside the plasma. The accuracy of the plasma shape reconstruction has been assessed by comparing the CCS method and an equilibrium calculation in JT-60SA with a high elongation and triangularity of plasma shape. The CCS, on which both Dirichletmore » and Neumann conditions are unknown, is defined as a hypothetical surface located inside the real plasma region. The accuracy of the plasma shape reconstruction is sensitive to the CCS free parameters such as the number of unknown parameters and the shape in JT-60SA. It is found that the optimum number of unknown parameters and the size of the CCS that minimizes errors in the reconstructed plasma shape are in proportion to the plasma size. Furthermore, it is shown that the accuracy of the plasma shape reconstruction is greatly improved using the optimum number of unknown parameters and shape of the CCS, and the reachable reconstruction errors in plasma shape and locations of strike points are within the target ranges in JT-60SA.« less

  6. Structural modeling of tissue-specific mitochondrial alanyl-tRNA synthetase (AARS2) defects predicts differential effects on aminoacylation

    PubMed Central

    Euro, Liliya; Konovalova, Svetlana; Asin-Cayuela, Jorge; Tulinius, Már; Griffin, Helen; Horvath, Rita; Taylor, Robert W.; Chinnery, Patrick F.; Schara, Ulrike; Thorburn, David R.; Suomalainen, Anu; Chihade, Joseph; Tyynismaa, Henna

    2015-01-01

    The accuracy of mitochondrial protein synthesis is dependent on the coordinated action of nuclear-encoded mitochondrial aminoacyl-tRNA synthetases (mtARSs) and the mitochondrial DNA-encoded tRNAs. The recent advances in whole-exome sequencing have revealed the importance of the mtARS proteins for mitochondrial pathophysiology since nearly every nuclear gene for mtARS (out of 19) is now recognized as a disease gene for mitochondrial disease. Typically, defects in each mtARS have been identified in one tissue-specific disease, most commonly affecting the brain, or in one syndrome. However, mutations in the AARS2 gene for mitochondrial alanyl-tRNA synthetase (mtAlaRS) have been reported both in patients with infantile-onset cardiomyopathy and in patients with childhood to adulthood-onset leukoencephalopathy. We present here an investigation of the effects of the described mutations on the structure of the synthetase, in an effort to understand the tissue-specific outcomes of the different mutations. The mtAlaRS differs from the other mtARSs because in addition to the aminoacylation domain, it has a conserved editing domain for deacylating tRNAs that have been mischarged with incorrect amino acids. We show that the cardiomyopathy phenotype results from a single allele, causing an amino acid change R592W in the editing domain of AARS2, whereas the leukodystrophy mutations are located in other domains of the synthetase. Nevertheless, our structural analysis predicts that all mutations reduce the aminoacylation activity of the synthetase, because all mtAlaRS domains contribute to tRNA binding for aminoacylation. According to our model, the cardiomyopathy mutations severely compromise aminoacylation whereas partial activity is retained by the mutation combinations found in the leukodystrophy patients. These predictions provide a hypothesis for the molecular basis of the distinct tissue-specific phenotypic outcomes. PMID:25705216

  7. Estimation of performance of a J-T refrigerators operating with nitrogen-hydrocarbon mixtures and a coiled tubes-in-tube heat exchanger

    NASA Astrophysics Data System (ADS)

    Satya Meher, R.; Venkatarathnam, G.

    2018-06-01

    The exergy efficiency of Joule-Thomson (J-T) refrigerators operating with mixtures (MRC systems) strongly depends on the choice of refrigerant mixture and the performance of the heat exchanger used. Helically coiled, multiple tubes-in-tube heat exchangers with an effectiveness of over 96% are widely used in these types of systems. All the current studies focus only on the different heat transfer correlations and the uncertainty in predicting performance of the heat exchanger alone. The main focus of this work is to estimate the uncertainty in cooling capacity when the homogenous model is used by comparing the theoretical and experimental studies. The comparisons have been extended to some two-phase models present in the literature as well. Experiments have been carried out on a J-T refrigerator at a fixed heat load of 10 W with different nitrogen-hydrocarbon mixtures in the evaporator temperature range of 100-120 K. Different heat transfer models have been used to predict the temperature profiles as well as the cooling capacity of the refrigerator. The results show that the homogenous two-phase flow model is probably the most suitable model for rating the cooling capacity of a J-T refrigerator operating with nitrogen-hydrocarbon mixtures.

  8. DC-9 Flight Demonstration Program with Refanned JT8D Engines. Volume 3; Performance and Analysis

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The JT8D-109 engine has a sea level static, standard day bare engine takeoff thrust of 73,840 N. At sea level standard day conditions the additional thrust of the JT8D-109 results in 2,040 kg additional takeoff gross weight capability for a given field length. Range loss of the DC-9 Refan airplane for long range cruise was determined. The Refan airplane demonstrated stall, static longitudinal stability, longitudinal control, longitudinal trim, minimum control speeds, and directional control characteristics similar to the DC-9-30 production airplane and complied with airworthiness requirements. Cruise, climb, and thrust reverser performance were evaluated. Structural and dynamic ground test, flight test and analytical results substantiate Refan Program requirements that the nacelle, thrust reverser hardware, and the airplane structural modifications are flightworthy and certifiable and that the airplane meets flutter speed margins. Estimated unit cost of a DC-9 Refan retrofit program is 1.338 million in mid-1975 dollars with about an equal split in cost between airframe and engine.

  9. Estimating the gas transfer velocity: a prerequisite for more accurate and higher resolution GHG fluxes (lower Aare River, Switzerland)

    NASA Astrophysics Data System (ADS)

    Sollberger, S.; Perez, K.; Schubert, C. J.; Eugster, W.; Wehrli, B.; Del Sontro, T.

    2013-12-01

    Currently, carbon dioxide (CO2) and methane (CH4) emissions from lakes, reservoirs and rivers are readily investigated due to the global warming potential of those gases and the role these inland waters play in the carbon cycle. However, there is a lack of high spatiotemporally-resolved emission estimates, and how to accurately assess the gas transfer velocity (K) remains controversial. In anthropogenically-impacted systems where run-of-river reservoirs disrupt the flow of sediments by increasing the erosion and load accumulation patterns, the resulting production of carbonic greenhouse gases (GH-C) is likely to be enhanced. The GH-C flux is thus counteracting the terrestrial carbon sink in these environments that act as net carbon emitters. The aim of this project was to determine the GH-C emissions from a medium-sized river heavily impacted by several impoundments and channelization through a densely-populated region of Switzerland. Estimating gas emission from rivers is not trivial and recently several models have been put forth to do so; therefore a second goal of this project was to compare the river emission models available with direct measurements. Finally, we further validated the modeled fluxes by using a combined approach with water sampling, chamber measurements, and highly temporal GH-C monitoring using an equilibrator. We conducted monthly surveys along the 120 km of the lower Aare River where we sampled for dissolved CH4 (';manual' sampling) at a 5-km sampling resolution, and measured gas emissions directly with chambers over a 35 km section. We calculated fluxes (F) via the boundary layer equation (F=K×(Cw-Ceq)) that uses the water-air GH-C concentration (C) gradient (Cw-Ceq) and K, which is the most sensitive parameter. K was estimated using 11 different models found in the literature with varying dependencies on: river hydrology (n=7), wind (2), heat exchange (1), and river width (1). We found that chamber fluxes were always higher than boundary

  10. Development of the negative ion beams relevant to ITER and JT-60SA at Japan Atomic Energy Agency.

    PubMed

    Hanada, M; Kojima, A; Tobari, H; Nishikiori, R; Hiratsuka, J; Kashiwagi, M; Umeda, N; Yoshida, M; Ichikawa, M; Watanabe, K; Yamano, Y; Grisham, L R

    2016-02-01

    In order to realize negative ion sources and accelerators to be applicable to International Thermonuclear Experimental Reactor and JT-60 Super Advanced, a large cesium (Cs)-seeded negative ion source and a multi-aperture and multi-stage electric acceleration have been developed at Japan Atomic Energy Agency (JAEA). Long pulse production and acceleration of the negative ion beams have been independently carried out. The long pulse production of the high current beams has achieved 100 s at the beam current of 15 A by modifying the JT-60 negative ion source. The pulse duration time is increased three times longer than that before the modification. As for the acceleration, a pulse duration time has been also extended two orders of magnitudes from 0.4 s to 60 s. The developments of the negative ion source and acceleration at JAEA are well in progress towards the realization of the negative ion sources and accelerators for fusion applications.

  11. JT8D high pressure compressor performance improvement

    NASA Technical Reports Server (NTRS)

    Gaffin, W. O.

    1981-01-01

    An improved performance high pressure compressor with potential application to all models of the JT8D engine was designed. The concept consisted of a trenched abradable rubstrip which mates with the blade tips for each of the even rotor stages. This feature allows tip clearances to be set so blade tips run at or near the optimum radius relative to the flowpath wall, without the danger of damaging the blades during transients and maneuvers. The improved compressor demonstrated thrust specific fuel consumption and exhaust gas temperature improvements of 1.0 percent and at least 10 C over the takeoff and climb power range at sea level static conditions, compared to a bill-of-material high pressure compressor. Surge margin also improved 4 percentage points over the high power operating range. A thrust specific fuel consumption improvement of 0.7 percent at typical cruise conditions was calculated based on the sea level test results.

  12. Relationship between composition of mixture charged and that in circulation in an auto refrigerant cascade and a J-T refrigerator operating in liquid refrigerant supply mode

    NASA Astrophysics Data System (ADS)

    Sreenivas, Bura; Nayak, H. Gurudath; Venkatarathnam, G.

    2017-01-01

    The composition of the refrigerant mixture in circulation during steady state operation of J-T and allied refrigerators is not the same as that charged due to liquid hold up in the heat exchangers and phase separators, as well as the differential solubility of different refrigerant components in the compressor lubricating oil. The performance of refrigerators/liquefiers operating on mixed refrigerant cycles is dependent on the mixture composition. It is therefore important to charge the right mixture that results in an optimum composition in circulation during steady state operation. The relationship between the charged and circulating composition has been experimentally studied in a J-T refrigerator operating in the liquid refrigerant supply (LRS) mode and an auto refrigerant cascade refrigerator (with a phase separator) operating in the gas refrigerant supply (GRS) mode. The results of the study are presented in this work. The results show that the method presented earlier for J-T refrigerators operating in GRS mode is also applicable in the case of refrigerators studied in this work.

  13. JT15D simulated flight data evaluation

    NASA Technical Reports Server (NTRS)

    Holm, R. G.

    1984-01-01

    The noise characteristics of the JT15D turbofan engine was analyzed with the objectives of: (1) assessing the state-of-art ability to simulate flight acoustic data using test results acquired in wind tunnel and outdoor (turbulence controlled) environments; and (2) predicting the farfield noise directivity of the blade passage frequency (BPF) tonal components using results from rotor blade mounted dynamic pressure instrumentation. Engine rotor tip speeds at subsonic, transonic, and supersonic conditions were evaluated. The ability to simulate flight results was generally within 2-3 dB for both outdoor and wind tunnel acoustic results. Some differences did occur in the broadband noise level and in the multiple-pure-tone harmonics at supersonic tip speeds. The prediction of blade passage frequency tone directivity from dynamic pressure measurements was accomplished for the three tip speed conditions. Predictions were made of the random and periodic components of the tone directivity. The technique for estimating the random tone component used hot wire data to establish a correlation between dynamic pressure and turbulence intensity. This prediction overestimated the tone level by typically 10 dB with the greatest overestimates occurring at supersonic conditions.

  14. Diagnostic Accuracy of APRI, AAR, FIB-4, FI, and King Scores for Diagnosis of Esophageal Varices in Liver Cirrhosis: A Retrospective Study.

    PubMed

    Deng, Han; Qi, Xingshun; Peng, Ying; Li, Jing; Li, Hongyu; Zhang, Yongguo; Liu, Xu; Sun, Xiaolin; Guo, Xiaozhong

    2015-12-20

    BACKGROUND Aspartate aminotransferase-to-platelet ratio index (APRI), aspartate aminotransferase-to-alanine aminotransferase ratio (AAR), FIB-4, fibrosis index (FI), and King scores might be alternatives to the use of upper gastrointestinal endoscopy for the diagnosis of esophageal varices (EVs) in liver cirrhosis. This study aimed to evaluate their diagnostic accuracy in predicting the presence and severity of EVs in liver cirrhosis. MATERIAL AND METHODS All patients who were consecutively admitted to our hospital and underwent upper gastrointestinal endoscopy between January 2012 and June 2014 were eligible for this retrospective study. Areas under curve (AUCs) were calculated. Subgroup analyses were performed according to the history of upper gastrointestinal bleeding (UGIB) and splenectomy. RESULTS A total of 650 patients with liver cirrhosis were included, and 81.4% of them had moderate-severe EVs. In the overall analysis, the AUCs of these non-invasive scores for predicting moderate-severe EVs and presence of any EVs were 0.506-0.6 and 0.539-0.612, respectively. In the subgroup analysis of patients without UGIB, their AUCs for predicting moderate-severe varices and presence of any EVs were 0.601-0.664 and 0.596-0.662, respectively. In the subgroup analysis of patients without UGIB or splenectomy, their AUCs for predicting moderate-severe varices and presence of any EVs were 0.627-0.69 and 0.607-0.692, respectively. CONCLUSIONS APRI, AAR, FIB-4, FI, and King scores had modest diagnostic accuracy of EVs in liver cirrhosis. They might not be able to replace the utility of upper gastrointestinal endoscopy for the diagnosis of EVs in liver cirrhosis.

  15. Diagnostic Accuracy of APRI, AAR, FIB-4, FI, and King Scores for Diagnosis of Esophageal Varices in Liver Cirrhosis: A Retrospective Study

    PubMed Central

    Deng, Han; Qi, Xingshun; Peng, Ying; Li, Jing; Li, Hongyu; Zhang, Yongguo; Liu, Xu; Sun, Xiaolin; Guo, Xiaozhong

    2015-01-01

    Background Aspartate aminotransferase-to-platelet ratio index (APRI), aspartate aminotransferase-to-alanine aminotransferase ratio (AAR), FIB-4, fibrosis index (FI), and King scores might be alternatives to the use of upper gastrointestinal endoscopy for the diagnosis of esophageal varices (EVs) in liver cirrhosis. This study aimed to evaluate their diagnostic accuracy in predicting the presence and severity of EVs in liver cirrhosis. Material/Methods All patients who were consecutively admitted to our hospital and underwent upper gastrointestinal endoscopy between January 2012 and June 2014 were eligible for this retrospective study. Areas under curve (AUCs) were calculated. Subgroup analyses were performed according to the history of upper gastrointestinal bleeding (UGIB) and splenectomy. Results A total of 650 patients with liver cirrhosis were included, and 81.4% of them had moderate-severe EVs. In the overall analysis, the AUCs of these non-invasive scores for predicting moderate-severe EVs and presence of any EVs were 0.506–0.6 and 0.539–0.612, respectively. In the subgroup analysis of patients without UGIB, their AUCs for predicting moderate-severe varices and presence of any EVs were 0.601–0.664 and 0.596–0.662, respectively. In the subgroup analysis of patients without UGIB or splenectomy, their AUCs for predicting moderate-severe varices and presence of any EVs were 0.627–0.69 and 0.607–0.692, respectively. Conclusions APRI, AAR, FIB-4, FI, and King scores had modest diagnostic accuracy of EVs in liver cirrhosis. They might not be able to replace the utility of upper gastrointestinal endoscopy for the diagnosis of EVs in liver cirrhosis. PMID:26687574

  16. The JT9D Jet Engine Diagnostics Program

    NASA Technical Reports Server (NTRS)

    Olsson, W. J.

    1982-01-01

    The various engine deterioration phenomena that affect JT9D performance retention were studied, and approaches to improve performance retention of engines were identified. The program included surveys of historical data, monitoring of in service engines, ground and flight testing of instrumented engines, analysis, and analytical modeling. Performance deterioration is made up of both short and long term modes, both of which are flight cycle related phenomena. Short term deterioration occurs primarily during airplane acceptance testing prior to delivery to the airline. This effect is caused by flight load and power induced clearance closures and engine deflections with resulting rubbing of airfoils and seals. Long term deterioration is caused by erosion of airfoils and gas path seals during ground operation and take off and by cyclic induced thermal distortion of the high pressure turbine airfoils. Studies of possible remedial approaches have shown that performance retention within 1 to 2 percent of initial revenue service performance can be achieved with a proper program of hot section and cold section maintenance.

  17. Design of collection optics and polychromators for a JT-60SA Thomson scattering system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tojo, H.; Hatae, T.; Sakuma, T.

    2010-10-15

    This paper presents designs of collection optics for a JT-60SA Thomson scattering system. By using tangential (to the toroidal direction) YAG laser injection, three collection optics without strong chromatic aberration generated by the wide viewing angle and small design volume were found to measure almost all the radial space. For edge plasma measurements, the authors optimized the channel number and wavelength ranges of band-pass filters in a polychromator to reduce the relative error in T{sub e} by considering all spatial channels and a double-pass laser system with different geometric parameters.

  18. Miniature Joule Thomson (JT) CryoCoolers for Propellant Management

    NASA Technical Reports Server (NTRS)

    Kapat, Jay; Chow, Louis

    2002-01-01

    A proof-of-concept project is proposed here that would attempt to demonstrate how miniature cryocoolers can be used to chill the vacuum jacket line of a propellant transfer line and thus to achieve transfer line pre-chill, zero boil off and possible propellant densification. The project would be performed both at UCF and KSC, with all of the cryogenic testing taking place in the KSC cryogenic test bed. A LN2 line available in that KSC test facility would serve to simulate a LOX transfer line. Under this project, miniature and highly efficient cold heads would be designed. Two identical cold heads will be fabricated and then integrated with a JT-type cryogenic system (consisting of a common compressor and a common external heat exchanger). The two cold heads will be integrated into the vacuum jacket of a LN2 line in the KSC cryo lab, where the testing will take place.

  19. Antimisting kerosene JT3 engine fuel system integration study

    NASA Technical Reports Server (NTRS)

    Fiorentino, A.

    1987-01-01

    An analytical study and laboratory tests were conducted to assist NASA in determining the safety and mission suitability of the modified fuel system and flight tests for the Full-Scale Transport Controlled Impact Demonstration (CID) program. This twelve-month study reviewed and analyzed both the use of antimisting kerosene (AMK) fuel and the incorporation of a fuel degrader on the operational and performance characteristics of the engines tested. Potential deficiencies and/or failures were identified and approaches to accommodate these deficiencies were recommended to NASA Ames -Dryden Flight Research Facility. The result of flow characterization tests on degraded AMK fuel samples indicated levels of degradation satisfactory for the planned missions of the B-720 aircraft. The operability and performance with the AMK in a ground test engine and in the aircraft engines during the test flights were comparable to those with unmodified Jet A. For the final CID test, the JT-3C-7 engines performed satisfactorily while operating on AMK right up to impact.

  20. Oxygen chemisorption compressor study for cryogenic J-T refrigeration

    NASA Technical Reports Server (NTRS)

    Jones, Jack A.; Blue, Gary D.

    1987-01-01

    Over twenty potentially reversible heat-powered oxide reactions have been studied and/or tested to determine their potential use as thermochemical oxygen compressors for cryogenic J-T LO2 refrigerators. One gas-solid compound family, Pr(1-n)Ce(n)O(x), proved to be completely reversible with fast kinetics for all pressure ranges tested below 650 C. With a heat-powered charcoal/methane physical adsorption upper stage and a Pr(1-n)Ce(n)O(x) chemisorption lower stage, temperatures should be attainable in the 55-80 K range for less power and over five times less weight than for charcoal/nitrogen sorption refrigeration systems. Total system power requirements with a hydride chemisorption lower stage (10 K to 7 K minimum) are about three times less than any mechanical refrigerator, and spacecraft refrigeration weights are about twenty times less. Due to the lack of wear-related moving parts in sorption refrigerators, life expectancy is at least ten years, and there essentially no vibration.

  1. JT8D-15/17 High Pressure Turbine Root Discharged Blade Performance Improvement. [engine design

    NASA Technical Reports Server (NTRS)

    Janus, A. S.

    1981-01-01

    The JT8D high pressure turbine blade and seal were modified, using a more efficient blade cooling system, improved airfoil aerodynamics, more effective control of secondary flows, and improved blade tip sealing. Engine testing was conducted to determine the effect of these improvements on performance. The modified turbine package demonstrated significant thrust specific fuel consumption and exhaust gas temperature improvements in sea level and altitude engine tests. Inspection of the improved blade and seal hardware after testing revealed no unusual wear or degradation.

  2. Compact antenna for two-dimensional beam scan in the JT-60U electron cyclotron heating/current drive system

    NASA Astrophysics Data System (ADS)

    Moriyama, S.; Kajiwara, K.; Takahashi, K.; Kasugai, A.; Seki, M.; Ikeda, Y.; Fujii, T.

    2005-11-01

    A compact antenna system was designed and fabricated to enable millimeter-wave beam scanning in the toroidal and poloidal directions of the JT-60U tokamak for electron cyclotron heating (ECH) and electron cyclotron current drive (ECCD) experiments. The antenna consists of a fast movable flat mirror mounted on the tokamak vacuum vessel and a rotary focusing mirror attached at the end of the waveguide that is supported from outside the vacuum vessel. This separate support concept enables a compact structure inside a shallow port (0.68×0.54×0.2m) that is shared with a subport for an independent diagnostic system. During a plasma shot, the flat mirror is driven by a servomotor with a 3-m-long drive shaft to reduce the influence of the high magnetic field on the motor. The focusing mirror is rotated by a simple mechanism utilizing a push rod and an air cylinder. The antenna has been operated reliably for 3 years after a small improvement to the rotary drive mechanism. It has made significant contributions to ECH and ECCD experiments, especially the current profile control in JT-60U.

  3. Numerical investigation of transient behaviour of the recuperative heat exchanger in a MR J-T cryocooler using different heat transfer correlations

    NASA Astrophysics Data System (ADS)

    Damle, R. M.; Ardhapurkar, P. M.; Atrey, M. D.

    2016-12-01

    In J-T cryocoolers operating with mixed refrigerants (nitrogen-hydrocarbons), the recuperative heat exchange takes place under two-phase conditions. Simultaneous boiling of the low pressure stream and condensation of the high pressure stream results in higher heat transfer coefficients. The mixture composition, operating conditions and the heat exchanger design are crucial for obtaining the required cryogenic temperature. In this work, a one-dimensional transient algorithm is developed for the simulation of the two-phase heat transfer in the recuperative heat exchanger of a mixed refrigerant J-T cryocooler. Modified correlation is used for flow boiling of the high pressure fluid while different condensation correlations are employed with and without the correction for the low pressure fluid. Simulations are carried out for different mixture compositions and numerical predictions are compared with the experimental data. The overall heat transfer is predicted reasonably well and the qualitative trends of the temperature profiles are also captured by the developed numerical model.

  4. Acceleration of 500 keV Negative Ion Beams By Tuning Vacuum Insulation Distance On JT-60 Negative Ion Source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kojima, A.; Hanada, M.; Tanaka, Y.

    2011-09-26

    Acceleration of a 500 keV beam up to 2.8 A has been achieved on a JT-60U negative ion source with a three-stage accelerator by overcoming low voltage holding which is one of the critical issues for realization of the JT-60SA ion source. In order to improve the voltage holding, preliminary voltage holding tests with small-size grids with uniform and locally intense electric fields were carried out, and suggested that the voltage holding was degraded by both the size and local electric field effects. Therefore, the local electric field was reduced by tuning gap lengths between the large size grids andmore » grid support structures of the accelerator. Moreover, a beam radiation shield which limited extension of the minimum gap length was also optimized so as to reduce the local electric field while maintaining the shielding effect. These modifications were based on the experiment results, and significantly increased the voltage holding from <150 kV/stage for the original configuration to 200 kV/stage. These techniques for improvement of voltage holding should also be applicable to other large ion sources accelerators such as those for ITER.« less

  5. Flight effects on noise by the JT8D engine with inverted primary/fan flow as measured in the NASA-Ames 40 by 80 foot wind tunnel

    NASA Technical Reports Server (NTRS)

    Strout, F. G.

    1978-01-01

    A JT8D-17R engine with inverted primary and fan flows was tested under static conditions as well as in the NASA Ames 40 by 80 Foot Wind Tunnel to determine static and flight noise characteristics, and flow profile of a large scale engine. Test and analysis techniques developed by a previous model and JT8D engine test program were used to determine the in-flight noise. The engine with inverted flow was tested with a conical nozzle and with a plug nozzle, 20 lobe nozzle, and an acoustic shield. Wind tunnel results show that forward velocity causes significant reduction in peak PNL suppression relative to uninverted flow. The loss of EPNL suppression is relatively modest. The in-flight peak PNL suppression of the inverter with conical nozzle was 2.5 PNdb relative to a static value of 5.5 PNdb. The corresponding EPNL suppression was 4.0 EPNdb for flight and 5.0 EPNdb for static operation. The highest in-flight EPNL suppression was 7.5 EPNdb obtained by the inverter with 20 lobe nozzle and acoustic shield. When compared with the JT8D engine with internal mixer, the inverted flow configuration provides more EPNL suppression under both static and flight conditions.

  6. Fast collimated neutron flux measurement using stilbene scintillator and flashy analog-to-digital converter in JT-60U

    NASA Astrophysics Data System (ADS)

    Ishikawa, M.; Itoga, T.; Okuji, T.; Nakhostin, M.; Shinohara, K.; Hayashi, T.; Sukegawa, A.; Baba, M.; Nishitani, T.

    2006-10-01

    A line-integrated neutron emission profile is routinely measured using the radial neutron collimator system in JT-60U tokamak. Stilbene neuron detectors (SNDs), which combine a stilbene organic crystal scintillation detector (SD) with an analog neutron-gamma pulse shape discrimination (PSD) circuit, have been used to measure collimated neutron flux. Although the SND has many advantages as a neutron detector, the maximum count rate is limited up to ˜1×105counts/s due to the analog PSD circuit. To overcome this issue, a digital signal processing system (DSPS) using a flash analog-to-digital converter (Acqiris DC252, 8GHz, 10bits) has been developed at Cyclotron and Radioisotope Center in Tohoku University. In this system anode signals from photomultiplier of the SD are directory stored and digitized. Then, the PSD between neutrons and gamma rays is performed using software. The DSPS has been installed in the vertical neutron collimator system in JT-60U and applied to deuterium experiments. It is confirmed that the PSD is sufficiently performed and collimated neutron flux is successfully measured with count rate up to ˜5×105counts/s without the effect of pileup of detected pulses. The performance of the DSPS as a neutron detector, which supersedes the SND, is demonstrated.

  7. Phase 2 program on ground test of refanned JT8D turbofan engines and nacelles for the 727 airplane. Volume 1: Summary

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The propulsion performance, acoustic, structural, and systems changes to a 727-200 airplane retrofitted with a refan modification of the JT8D turbofan engine are evaluated. Model tests, design of certifiable airplane retrofit kit hardware, manufacture of test hardware, ground test of a current production JT8D engine, followed by test of the same engine modified to the refan configuration, detailed analyses of the retrofit impact on airplane airworthiness, performance, and noise, and a preliminary analysis of retrofit costs are included. Results indicate that the refan retrofit of the 727-200 would be certifiable and would result in a 6-to 8 EPNdb reduction in effective perceived noise level (EPNL) at the FAR 36 measuring points and an annoyance-weighted footprint area reduction of 68% to 83%. The installed refan engine is estimated to provide 14% greater takeoff thrust at zero velocity and 10% greater thrust at 100 kn (51.4 m/s). There would be an approximate 0.6% increase in cruise specific fuel consumption (SFC). The refan engine performance in conjunction with the increase in stalled weight results in a range reduction of approximately 15% over the unmodified airplane at the same brake release gross weight (BRGW), with a block fuel increase of 1.5% to 3%. With the particular model 727 that was studied, however, it is possible to operate the airplane (with minor structural modifications) at a higher BRGW and increase the range up to approximately 15% relative to the nonrefanned airplane (with equal or slightly increased noise levels). The JT8D refan engine also improves the limited-field range of the airplane.

  8. Design and development of a four-cell sorption compressor based J-T cooler using R134a as working fluid

    NASA Astrophysics Data System (ADS)

    Mehta, R. N.; Bapat, S. L.; Atrey, M. D.

    2014-01-01

    The need of a cooler with no electromagnetic interference and practically zero vibration has led to sorption compressor based Joule-Thomson (J-T) coolers. These are useful for sophisticated electronic, ground based and space borne systems. In a Sorption compressor, adsorbed gases are desorbed into a confined volume by raising temperature of the sorption bed resulting in an increase in pressure of the liberated gas. In order to have the system (compressor) functioning on a continuous basis, with almost a constant gas flow rate, multiple cells are used with the adaptation of Temperature Swing Adsorption (TSA) process. As the mass of the desorbed gas dictates the compressor throughput, a combination of sorbent material with high adsorption capacity for a chosen gas or gas mixture has to be selected for efficient operation of the compressor. Commercially available (coconut-shell base) activated carbon has been selected for the present application. The characterization study for variation of discharge pressure is used to design the Four-cell sorption compressor based cryocooler with a desired output. Apart from compressor, the system includes a) After cooler b) Return gas heat exchanger c) capillary tube as the J-T expansion device and d) Evaporator.

  9. Fast neutron-gamma discrimination on neutron emission profile measurement on JT-60U.

    PubMed

    Ishii, K; Shinohara, K; Ishikawa, M; Baba, M; Isobe, M; Okamoto, A; Kitajima, S; Sasao, M

    2010-10-01

    A digital signal processing (DSP) system is applied to stilbene scintillation detectors of the multichannel neutron emission profile monitor in JT-60U. Automatic analysis of the neutron-γ pulse shape discrimination is a key issue to diminish the processing time in the DSP system, and it has been applied using the two-dimensional (2D) map. Linear discriminant function is used to determine the dividing line between neutron events and γ-ray events on a 2D map. In order to verify the validity of the dividing line determination, the pulse shape discrimination quality is evaluated. As a result, the γ-ray contamination in most of the beam heating phase was negligible compared with the statistical error with 10 ms time resolution.

  10. Long-pulse production of high current negative ion beam by using actively temperature controlled plasma grid for JT-60SA negative ion source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kojima, A.; Hanada, M.; Yoshida, M.

    2015-04-08

    The temperature control system of the large-size plasma grid has been developed to realize the long pulse production of high-current negative ions for JT-60SA. By using this prototype system for the JT-60SA ion source, 15 A negative ions has been sustained for 100 s for the first time, which is three times longer than that obtained in JT-60U. In this system, a high-temperature fluorinated fluid with a high boiling point of 270 degree Celsius is circulated in the cooling channels of the plasma grids (PG) where a cesium (Cs) coverage is formed to enhance the negative ion production. Because themore » PG temperature control had been applied to only 10% of the extraction area previously, the prototype PG with the full extraction area (110 cm × 45 cm) was developed to increase the negative ion current in this time. In the preliminary results of long pulse productions of high-current negative ions at a Cs conditioning phase, the negative ion production was gradually degraded in the last half of 100 s pulse where the temperature of an arc chamber wall was not saturated. From the spectroscopic measurements, it was found that the Cs flux released from the wall might affect to the negative ion production, which implied the wall temperature should be kept low to control the Cs flux to the PG for the long-pulse high-current production. The obtained results of long-pulse production and the PG temperature control method contributes the design of the ITER ion source.« less

  11. Design of tangential viewing phase contrast imaging for turbulence measurements in JT-60SA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tanaka, K., E-mail: ktanaka@nifs.ac.jp; Department of Advanced Energy Engineering, Kyushu University, Kasuga, Fukuoka 816-8580; Coda, S.

    2016-11-15

    A tangential viewing phase contrast imaging system is being designed for the JT-60SA tokamak to investigate microturbulence. In order to obtain localized information on the turbulence, a spatial-filtering technique is applied, based on magnetic shearing. The tangential viewing geometry enhances the radial localization. The probing laser beam is injected tangentially and traverses the entire plasma region including both low and high field sides. The spatial resolution for an Internal Transport Barrier discharge is estimated at 30%–70% of the minor radius at k = 5 cm{sup −1}, which is the typical expected wave number of ion scale turbulence such as ionmore » temperature gradient/trapped electron mode.« less

  12. Expanded study of feasibility of measuring in-flight 747/JT9D loads, performance, clearance, and thermal data

    NASA Technical Reports Server (NTRS)

    Sallee, G. P.; Martin, R. L.

    1980-01-01

    The JT9D jet engine exhibits a TSFC loss of about 1 percent in the initial 50 flight cycles of a new engine. These early losses are caused by seal-wear induced opening of running clearances in the engine gas path. The causes of this seal wear have been identified as flight induced loads which deflect the engine cases and rotors, causing the rotating blades to rub against the seal surfaces, producing permanent clearance changes. The real level of flight loads encountered during airplane acceptance testing and revenue service and the engine's response in the dynamic flight environment were investigated. The feasibility of direct measurement of these flight loads and their effects by concurrent measurement of 747/JT9D propulsion system aerodynamic and inertia loads and the critical engine clearance and performance changes during 747 flight and ground operations was evaluated. A number of technical options were examined in relation to the total estimated program cost to facilitate selection of the most cost effective option. It is concluded that a flight test program meeting the overall objective of determining the levels of aerodynamic and inertia load levels to which the engine is exposed during the initial flight acceptance test and normal flight maneuvers is feasible and desirable. A specific recommended flight test program, based on the evaluation of cost effectiveness, is defined.

  13. Turbulence characteristics of compressor discharge flows. [JT9D engine tests

    NASA Technical Reports Server (NTRS)

    Grant, H. P.

    1979-01-01

    Turbulence measurements were conducted in a large gas turbine engine (JT9D) at the entrance to the diffuser duct, joining the compressor discharge to the combustor inlet. Hot film probe and hot wire probe measurements were obtained at temperatures from 450K (350F) (idle) to 608K (635F) (rich approach). At I.D. (25 percent span) and mid-span locations, the turbulence intensity increased slightly from 6 + or - percent at idle condition to 7 or - 1 percent at rich approach. At O.D. (75 percent span) the turbulent intensity increased more rapidly, from 7.5 + or - 0.5 percent at idle to 15 + or - 0.5 percent at rich approach. The spectra showed turbulent energy distributed uniformly over a 0.1 to 5 KHz bandwidth (down 3db) at all operating conditions, corresponding to random turbulence with velocity wave lengths of 2 cm to 1 meter travelling at the mean velocity of 100 m/sec. Tests results are given in tables and graphs.

  14. Edge safety factor at the onset of plasma disruption during VDEs in JT-60U

    NASA Astrophysics Data System (ADS)

    Sugihara, Masayoshi; Lukash, Victor; Khayrutdinov, Rustam; Neyatani, Yuzuru

    2004-10-01

    Detailed examinations of the value of the edge safety factor (qa) at the onset of thermal quench (TQ) during intentional vertical displacement event (VDE) experiments in JT-60U are carried out using two different reconstruction methods, FBI/FBEQU and DINA. The results from the two methods are very similar and show that the TQ occurs when the qa value is in the range between 1.5 and 2. This result suggests that the predictive simulations for VDEs should be performed within this range of q to examine the subsequent differences in the halo currents, plasma movement and other plasma behaviour during the current quench.

  15. Lgr4 promotes prostate tumorigenesis through the Jmjd2a/AR signaling pathway.

    PubMed

    Zhang, Jianwei; Li, Qi; Zhang, Shaojin; Xu, Quanquan; Wang, Tianen

    2016-11-15

    Lgr4 (leucine-rich repeat domain containing G protein-coupled receptor 4) is implicated in the transcriptional regulation of multiple histone demethylases in the progression of diverse cancers, but there are few reports concerning the molecular mechanism by which Lgr4 regulates histone demethylase activation in prostate cancer (PCa) progression. As Jmjd2a is a histone demethylase, in the current study, we investigated the relationship between interaction Lgr4 with Jmjd 2a and Jmjd2a/androgen receptor (AR) signaling pathway in PCa progression. Firstly, Lgr4 was overexpressed by transfecting pcDNA3.1(+)/Lgr4 plasmids into PCa (LNCaP and PC-3) cell lines. Next, we found that Lgr4 overexpression promoted Jmjd2a mRNA expression, reduced cell apoptosis and arrested cell cycle in the S phase, these effects were reversed by Jmjd2a silencing. Moreover, Lgr4 overexpression markedly elevated AR levels and its interaction with Jmjd2a, which was tested by co-immunoprecipitation and luciferase reporter assays. Furthermore, interaction AR with PSA promoter (containing an AR response element) was obviously improved by Lgr4 overexpression, and PSA silencing reduced Lgr4-induced cell apoptosis and cell cycle arrest in PCa cells. Taken together, Lgr4 may be a novel tumor marker providing new mechanistic insights into PCa progression. Lgr4 activates Jmjd2a/AR signaling pathway to promote interaction AR with PSA promoter, causing reduction of PCa apoptosis and cell cycle arrest. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Fast neutron-gamma discrimination on neutron emission profile measurement on JT-60U

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ishii, K.; Okamoto, A.; Kitajima, S.

    2010-10-15

    A digital signal processing (DSP) system is applied to stilbene scintillation detectors of the multichannel neutron emission profile monitor in JT-60U. Automatic analysis of the neutron-{gamma} pulse shape discrimination is a key issue to diminish the processing time in the DSP system, and it has been applied using the two-dimensional (2D) map. Linear discriminant function is used to determine the dividing line between neutron events and {gamma}-ray events on a 2D map. In order to verify the validity of the dividing line determination, the pulse shape discrimination quality is evaluated. As a result, the {gamma}-ray contamination in most of themore » beam heating phase was negligible compared with the statistical error with 10 ms time resolution.« less

  17. Design and development of a four-cell sorption compressor based J-T cooler using R134a as working fluid

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mehta, R. N.; Bapat, S. L.; Atrey, M. D.

    The need of a cooler with no electromagnetic interference and practically zero vibration has led to sorption compressor based Joule-Thomson (J-T) coolers. These are useful for sophisticated electronic, ground based and space borne systems. In a Sorption compressor, adsorbed gases are desorbed into a confined volume by raising temperature of the sorption bed resulting in an increase in pressure of the liberated gas. In order to have the system (compressor) functioning on a continuous basis, with almost a constant gas flow rate, multiple cells are used with the adaptation of Temperature Swing Adsorption (TSA) process. As the mass of themore » desorbed gas dictates the compressor throughput, a combination of sorbent material with high adsorption capacity for a chosen gas or gas mixture has to be selected for efficient operation of the compressor. Commercially available (coconut-shell base) activated carbon has been selected for the present application. The characterization study for variation of discharge pressure is used to design the Four-cell sorption compressor based cryocooler with a desired output. Apart from compressor, the system includes a) After cooler b) Return gas heat exchanger c) capillary tube as the J-T expansion device and d) Evaporator.« less

  18. Plasma equilibrium control during slow plasma current quench with avoidance of plasma-wall interaction in JT-60U

    NASA Astrophysics Data System (ADS)

    Yoshino, R.; Nakamura, Y.; Neyatani, Y.

    1997-08-01

    In JT-60U a vertical displacement event (VDE) is observed during slow plasma current quench (Ip quench) for a vertically elongated divertor plasma with a single null. The VDE is generated by an error in the feedback control of the vertical position of the plasma current centre (ZJ). It has been perfectly avoided by improving the accuracy of the ZJ measurement in real time. Furthermore, plasma-wall interaction has been avoided successfully during slow Ip quench owing to the good performance of the plasma equilibrium control system

  19. Anisotropic electron temperature measurements without knowing the spectral transmissivity for a JT-60SA Thomson scattering diagnostic.

    PubMed

    Tojo, H; Hatae, T; Yatsuka, E; Itami, K

    2012-10-01

    This paper focuses on a method for measuring the electron temperature (T(e)) without knowing the transmissivity using Thomson scattering diagnostic with a double-pass scattering system. Application of this method for measuring the anisotropic T(e), i.e., the T(e) in the directions parallel (T(eparallel)) and perpendicular (T(eperpendicular)) to the magnetic field, is proposed. Simulations based on the designed parameters for a JT-60SA indicate the feasibility of the measurements except in certain T(e) ranges, e.g., T(eparallel) ~ 3.5T(eperpendicular) at 120° of the scattering angle.

  20. Recovery of Retained Tritium from Graphite Tile of JT-60U

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Takeishi, Toshiharu; Katayama, Kazunari; Nishikawa, Masabumi

    Tritium thermal release and full combustion with oxygen were performed on isotropic graphite tiles used for plasma facing material of JT-60U. Approximately 50-80 % of tritium was released by dry argon gas purge and 20-50 % of tritium was released by humid argon gas purge up to 800-1200 deg. C within one day, respectively. Further several percent of tritium was released by full combustion with oxygen. It was experimentally confirmed that all retained tritium is not released by thermal dry gas purge and by use of isotope exchange reaction at high temperature in such a short period. In the fullmore » combustion operation, isotropic graphite begins to combust at higher temperature than 650 deg. C, but effective combustion temperature was higher than 700 deg. C. Since it is very difficult to heat the graphite tile attached on the wall of vacuum vessel at higher than 700 deg. C, it is considered to be not easy to recover all the tritium retained in the graphite while in the vacuum vessel.« less

  1. Behaviour of tritium in the vacuum vessel of JT-60U

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kobayashi, K.; Miya, N.; Ikeda, Y.

    2015-03-15

    The disassembly of the JT-60U torus started in 2010 after 18 years of deuterium plasma operations. The vessel is made of Inconel 625. Therefore, it was very important to study the hydrogen isotope (particularly tritium) behavior in Inconel 625 from the viewpoint of the clearance procedure. Inconel 625 specimen was exposed to the D{sub 2} (92.8 %) - T{sub 2} (7.2 %) gas mixture at 573 K for 5 hours. The tritium release from the specimen at 298 K was controlled for about 1 year. After that a part of tritium remaining in the specimen was released by heating upmore » to 1073 K. Other part of tritium trapped in the specimen was measured by chemical etching method. Most of the chemical form of the released tritium was HTO. The contaminated specimen by tritium was released continuously the diffusible tritium under the ambient condition. In the tritium release experiment, the amount of desorbed tritium was about 99% during 1 year. It was considered that the tritium in Inconel 625 was released easily.« less

  2. JT8D revised high-pressure turbine cooling and other outer air seal program

    NASA Technical Reports Server (NTRS)

    Gaffin, W. O.

    1979-01-01

    The JT8D high pressure turbine was revised to reduce leakage between the blade tip shrouds and the outer air seal, and engine testing was performed to determine the effect on performance. The addition of a second knife-edge on the blade tip shroud, the extension of the honeycomb seal land to cover the added knife-edge and an existing spoiler on the shroud, and a material substitution in the seal support ring to improve thermal growth characteristics are included. A relocation of the blade cooling air discharge to insure adequate cooling flow is required. Significant specific fuel consumption and exhaust gas temperature improvements were demonstrated with the revised turbine in sea level and simulated altitude engine tests. Inspection of the revised seal hardware after these tests showed no unusual wear or degradation.

  3. The 727 airplane target thrust reverser static performance model test for refanned JT8D engines

    NASA Technical Reports Server (NTRS)

    Chow, C. T. P.; Atkey, E. N.

    1974-01-01

    The results of a scale model static performance test of target thrust reverser configurations for the Pratt and Whitney Aircraft JT8D-100 series engine are presented. The objective of the test was to select a series of suitable candidate reverser configurations for the subsequent airplane model wind tunnel ingestion and flight controls tests. Test results indicate that adequate reverse thrust performance with compatible engine airflow match is achievable for the selected configurations. Tapering of the lips results in loss of performance and only minimal flow directivity. Door pressure surveys were conducted on a selected number of lip and fence configurations to obtain data to support the design of the thrust reverser system.

  4. Cryogenic thermometry for refrigerant distribution system of JT-60SA

    NASA Astrophysics Data System (ADS)

    Natsume, K.; Murakami, H.; Kizu, K.; Yoshida, K.; Koide, Y.

    2015-12-01

    JT-60SA is a fully superconducting fusion experimental device involving Japan and Europe. The cryogenic system supplies supercritical or gaseous helium to superconducting coils through valve boxes or coil terminal boxes and in-cryostat pipes. There are 86 temperature measurement points at 4 K along the distribution line. Resistance temperature sensors will be installed on cooling pipes in vacuum. In this work, two sensor attachment methods, two types of sensor, two thermal anchoring methods, and two sensor fixation materials have been experimentally evaluated in terms of accuracy and mass productivity. Finally, the verification test of thermometry has been conducted using the sample pipe fabricated in the same way to the production version, which has been decided by the comparison experiments. The TVO sensor is attached by the saddle method with Apiezon N grease and the measurement wires made of phosphor bronze are wound on the pipe with Stycast 2850FT as the thermal anchoring. A Cernox sensor is directly immersed in liquid helium as a reference thermometer during the experiment. The measured temperature difference between the attached one and reference one has been within ±15 mK in the range of 3.40-4.73 K. It has satisfies the accuracy requirement of 0.1 K.

  5. Identity physics experiment on internal transport barriers in JT-60U and JET

    NASA Astrophysics Data System (ADS)

    de Vries, P. C.; Sakamoto, Y.; Litaudon, X.; Beurskens, M. N. A.; Brix, M.; Crombé, K.; Fujita, T.; Giroud, C.; Hawkes, N. C.; Hayashi, N.; Joffrin, E.; Mantica, P.; Matsunaga, G.; Oyama, N.; Parail, V.; Salmi, A.; Shinohara, K.; Strintzi, D.; Suzuki, T.; Takechi, M.; Takenaga, H.; Tala, T.; Tsalas, M.; Urano, H.; Voitsekhovitch, I.; Yoshida, M.; EFDA contributors, JET; JT-60 Team

    2009-12-01

    A series of experiments have been carried out in 2008 at JT-60U and JET to find common characteristics and explain differences between internal transport barriers (ITBs). The identity experiments succeeded in matching the profiles of most dimensionless parameters at the time ITBs were triggered. Thereafter the q-profile development deviated due to differences in non-inductive current density profile, affecting the ITB. Furthermore, the ITBs in JET were more strongly influenced by the H-mode pedestal or edge localized modes. It was found to be difficult to match the plasma rotation characteristics in both devices. However, the wide range of Mach numbers obtained in these experiments shows that the rotation has little effect on the triggering of ITBs in plasmas with reversed magnetic shear. On the other hand the toroidal rotation and more specifically the rotational shear had an impact on the subsequent growth and allowed the formation of strong ITBs.

  6. Evaluation of heat and particle controllability on the JT-60SA divertor

    NASA Astrophysics Data System (ADS)

    Kawashima, H.; Hoshino, K.; Shimizu, K.; Takizuka, T.; Ide, S.; Sakurai, S.; Asakura, N.

    2011-08-01

    The JT-60SA divertor design has been established on the basis of engineering requirements and physics analysis. Heat and particle fluxes under the full input power of 41 MW can give severe heat loads on the divertor targets, while the allowable heat load is limited below 15 MW/m2. Dependence of the heat flux mitigation on a D2 gas-puff is evaluated by SONIC simulations for high density (ne_ave ˜ 1 × 1020 m-3) high current plasmas. It is found that the peak heat load 10 MW/m2 with dense (ned > 4 × 1020 m-3) and cold (Ted, Tid ⩽ 1 eV) divertor plasmas are obtained at a moderate gas-puff of Γpuff = 15 × 1021 s-1. Divertor plasmas are controlled from attached to detached condition using the divertor pump with pumping-speed below 100 m3/s. In full non-inductive current drive plasmas with low density (ne_ave ˜ 5 × 1019 m-3), the reduction of divertor heat load is achieved with the Ar injection.

  7. Off-axis fishbone-like instability and excitation of resistive wall modes in JT-60U and DIII-D

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Okabayashi, M.; Solomon, W. M.; Budny, R. V.

    2011-05-15

    An energetic-particle (EP)-driven ''off-axis-fishbone-like mode (OFM)'' often triggers a resistive wall mode (RWM) in JT-60U and DIII-D devices, preventing long-duration high-{beta}{sub N} discharges. In these experiments, the EPs are energetic ions (70-85 keV) injected by neutral beams to produce high-pressure plasmas. EP-driven bursting events reduce the EP density and the plasma rotation simultaneously. These changes are significant in high-{beta}{sub N} low-rotation plasmas, where the RWM stability is predicted to be strongly influenced by the EP precession drift resonance and by the plasma rotation near the q=2 surface (kinetic effects). Analysis of these effects on stability with a self-consistent perturbation tomore » the mode structure using the MARS-K code showed that the impact of EP losses and rotation drop is sufficient to destabilize the RWM in low-rotation plasmas, when the plasma rotation normalized by Alfven frequency is only a few tenths of a percent near the q=2 surface. The OFM characteristics are very similar in JT-60U and DIII-D, including nonlinear mode evolution. The modes grow initially like a classical fishbone, and then the mode structure becomes strongly distorted. The dynamic response of the OFM to an applied n=1 external field indicates that the mode retains its external kink character. These comparative studies suggest that an energetic particle-driven 'off-axis-fishbone-like mode' is a new EP-driven branch of the external kink mode in wall-stabilized plasmas, analogous to the relationship of the classical fishbone branch to the internal kink mode.« less

  8. Effect of ceramic coating of JT8D combustor liner on maximum liner temperatures and other combustor performance parameters

    NASA Technical Reports Server (NTRS)

    Butze, H. F.; Liebert, C. H.

    1976-01-01

    The effect of ceramic coating of a JT8D combustor liner was investigated at simulated cruise and takeoff conditions with two fuels of widely different aromatic contents. Substantial decreases in maximum liner temperatures and flame radiation values were obtained with the ceramic-coated liner. Small reductions in exhaust gas smoke concentrations were observed with the ceramic-coated liner. Other performance parameters such as combustion efficiency and emissions of unburned hydrocarbons, CO, and NOx were not affected significantly. No deterioration of the ceramic coating was observed after about 6 hours of cyclic operation including several startups and shutdowns.

  9. Quantitative assessment of alkali-reactive aggregate mineral content through XRD using polished sections as a supplementary tool to RILEM AAR-1 (petrographic method)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Castro, Nelia, E-mail: nelia.castro@ntnu.no; Sorensen, Bjorn E.; Broekmans, Maarten A.T.M.

    The mineral content of 5 aggregate samples from 4 different countries, including reactive and non-reactive aggregate types, was assessed quantitatively by X-ray diffraction (XRD) using polished sections. Additionally, electron probe microanalyzer (EPMA) mapping and cathodoluminescence (CL) were used to characterize the opal-CT identified in one of the aggregate samples. Critical review of results from polished sections against traditionally powdered specimen has demonstrated that for fine-grained rocks without preferred orientation the assessment of mineral content by XRD using polished sections may represent an advantage over traditional powder specimens. Comparison of data on mineral content and silica speciation with expansion data frommore » PARTNER project confirmed that the presence of opal-CT plays an important role in the reactivity of one of the studied aggregates. Used as a complementary tool to RILEM AAR-1, the methodology suggested in this paper has the potential to improve the strength of the petrographic method.« less

  10. Dynamic transport study of the plasmas with transport improvement in LHD and JT-60U

    NASA Astrophysics Data System (ADS)

    Ida, K.; Sakamoto, Y.; Inagaki, S.; Takenaga, H.; Isayama, A.; Matsunaga, G.; Sakamoto, R.; Tanaka, K.; Ide, S.; Fujita, T.; Funaba, H.; Kubo, S.; Yoshinuma, M.; Shimozuma, T.; Takeiri, Y.; Ikeda, K.; Michael, C.; Tokuzawa, T.; LHD experimental Group; JT-60 Team

    2009-01-01

    Transport analysis during the transient phase of heating (a dynamic transport study) applied to the plasma with internal transport barriers (ITBs) in the Large Helical Device (LHD) heliotron and the JT-60U tokamak is described. In the dynamic transport study the time of transition from the L-mode plasma to the ITB plasma is clearly determined by the onset of flattening of the temperature profile in the core region and a spontaneous phase transition from a zero curvature ITB (hyperbolic tangent shaped ITB) or a positive curvature ITB (concaved shaped ITB) to a negative curvature ITB (convex shaped ITB) and its back-transition are observed. The flattening of the core region of the ITB transition and the back-transition between a zero curvature ITB and a convex ITB suggest the strong interaction of turbulent transport in space.

  11. Anisotropic electron temperature measurements without knowing the spectral transmissivity for a JT-60SA Thomson scattering diagnostic

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tojo, H.; Hatae, T.; Yatsuka, E.

    2012-10-15

    This paper focuses on a method for measuring the electron temperature (T{sub e}) without knowing the transmissivity using Thomson scattering diagnostic with a double-pass scattering system. Application of this method for measuring the anisotropic T{sub e}, i.e., the T{sub e} in the directions parallel (T{sub e Double-Vertical-Line Double-Vertical-Line }) and perpendicular (T{sub e Up-Tack }) to the magnetic field, is proposed. Simulations based on the designed parameters for a JT-60SA indicate the feasibility of the measurements except in certain T{sub e} ranges, e.g., T{sub e Double-Vertical-Line Double-Vertical-Line }{approx} 3.5T{sub e Up-Tack} at 120 Degree-Sign of the scattering angle.

  12. JT9D-70/59 Improved High Pressure Turbine Active Clearance Control System. [for specific fuel consumption improvement

    NASA Technical Reports Server (NTRS)

    Gaffin, W. O.

    1979-01-01

    The JT9D-70/59 high pressure turbine active clearance control system was modified to provide reduction of blade tip clearance when the system is activated during cruise operation. The modification increased the flow capacity and air impingement effectiveness of the cooling air manifold to augment turbine case shrinkage capability, and increased responsiveness of the airseal clearance to case shrinkage. The simulated altitude engine testing indicated a significant improvement in specific fuel consumption with the modified system. A 1000 cycle engine endurance test showed no unusual wear or performance deterioration effects on the engine or the clearance control system. Rig tests indicated that the air impingement and seal support configurations used in the engine tests are near optimum.

  13. Investigation of performance deterioration of the CF6/JT9D, high-bypass ratio turbofan engines

    NASA Technical Reports Server (NTRS)

    Ziemianski, J. A.; Mehalic, C. M.

    1980-01-01

    The aircraft energy efficiency program within NASA is developing technology required to improve the fuel efficiency of commercial subsonic transport aricraft. One segment of this program includes engine diagnostics which is directed toward determining the sources and causes of performance deterioration in the Pratt and Whitney Aircraft JT9D and General Electric CF6 high-bypass ratio turbofan engines and developing technology for minimizing the performance losses. Results of engine performance deterioration investigations based on historical data, special engine tests, and specific tests to define the influence of flight loads and component clearances on performance are presented. The results of analysis of several damage mechanisms that contribute to performance deterioration such as blade tip rubs, airfoil surface roughness and erosion, and thermal distortion are also included. The significance of these damage mechanisms on component and overall engine performance is discussed.

  14. Flight effects on noise generated by the JT8D-17 engine in a quiet nacelle and a conventional nacelle as measured in the NASA-Ames 40- by 80-foot wind tunnel

    NASA Technical Reports Server (NTRS)

    Strout, F. G.

    1976-01-01

    A JT8D-17 turbofan engine was tested in the NASA-Ames 40- by 80-foot wind tunnel to determine flight effects on jet and fan noise. Baseline, quiet nacelle with 20-lobe ejector/suppressor, and internal mixer configurations were tested over a range of engine power settings and tunnel velocities. Flight effects derived from the 40- by 80-foot wind tunnel test are compared with 727/JT8D flight test data and with model data obtained in a smaller wind tunnel. Procedures are defined for measuring noise data in a wind tunnel relatively near the sources and analyzing the results to obtain far-field flight effects. Wind tunnel and 727 flight test noise results compare favorably for both the baseline and quiet nacelle configurations. Two reports are provided, including a comprehensive version with extensive test results and analysis and the subject summary version that emphasizes data analysis and program finding.

  15. The Incidence, Classification, and Management of Acute Adverse Reactions to the Low-Osmolar Iodinated Contrast Media Isovue and Ultravist in Contrast-Enhanced Computed Tomography Scanning.

    PubMed

    Zhang, Bin; Dong, Yuhao; Liang, Long; Lian, Zhouyang; Liu, Jing; Luo, Xiaoning; Chen, Wenbo; Li, Xinyu; Liang, Changhong; Zhang, Shuixing

    2016-03-01

    Some epidemiologic surveillance studies have recorded adverse drug reactions to radiocontrast agents. We aimed to investigate the incidence and management of acute adverse reactions (AARs) to Ultravist-370 and Isovue-370 in patients who underwent contrast-enhanced computed tomography (CT) scanning.Data from 137,473 patients were analyzed. They had undergone enhanced CT scanning with intravenous injection of Ultravist-370 or Isovue-370 during the period of January 1, 2006 to December 31, 2012 in our hospital. We investigated and classified AARs according to the American College of Radiology and the Chinese Society of Radiology (CSR) guidelines for iodinated contrast media. We analyzed risk factors for AARs and compared the AARs induced by Ultravist-370 and Isovue-370.Four hundred and twenty-eight (0.31%) patients experienced AARs, which included 330 (0.24%) patients with mild AARs, 82 (0.06%) patients with moderate AARs, and 16 (0.01%) patients with severe AARs (including 3 cases of cardiac arrest and one case of death). The incidence of AARs was higher with Ultravist-370 than with Isovue-370 (0.38% vs 0.24%, P < 0.001), but only for mild AARs (0.32% vs 0.16%, P < 0.001). Analyses on risk factors indicated that female patients (n = 221, 0.43%, P < 0.001), emergency patients (n = 11, 0.51%, P < 0.001), elderly patients aged 50 to 60 years (n = 135, 0.43%, P < 0.001), and patients who underwent coronary computed tomography angiography (CTA) (n = 55, 0.51%, P < 0.001) had a higher risk of AARs. Cutaneous manifestations (50.52%)-especially rash (59.74%)-were the most frequent mild AARs. Cardiovascular manifestations accounted for most moderate and severe AARs (62.91% and 48.28%, respectively). After proper management, the symptoms and signs of 96.5% of the AARs resolved within 24 hours without sequelae.Ultravist-370 and Isovue-370 are safe for patients undergoing enhanced CT scanning. The incidence of AARs is higher with Ultravist

  16. The Incidence, Classification, and Management of Acute Adverse Reactions to the Low-Osmolar Iodinated Contrast Media Isovue and Ultravist in Contrast-Enhanced Computed Tomography Scanning

    PubMed Central

    Zhang, Bin; Dong, Yuhao; Liang, Long; Lian, Zhouyang; Liu, Jing; Luo, Xiaoning; Chen, Wenbo; Li, Xinyu; Liang, Changhong; Zhang, Shuixing

    2016-01-01

    Abstract Some epidemiologic surveillance studies have recorded adverse drug reactions to radiocontrast agents. We aimed to investigate the incidence and management of acute adverse reactions (AARs) to Ultravist-370 and Isovue-370 in patients who underwent contrast-enhanced computed tomography (CT) scanning. Data from 137,473 patients were analyzed. They had undergone enhanced CT scanning with intravenous injection of Ultravist-370 or Isovue-370 during the period of January 1, 2006 to December 31, 2012 in our hospital. We investigated and classified AARs according to the American College of Radiology and the Chinese Society of Radiology (CSR) guidelines for iodinated contrast media. We analyzed risk factors for AARs and compared the AARs induced by Ultravist-370 and Isovue-370. Four hundred and twenty-eight (0.31%) patients experienced AARs, which included 330 (0.24%) patients with mild AARs, 82 (0.06%) patients with moderate AARs, and 16 (0.01%) patients with severe AARs (including 3 cases of cardiac arrest and one case of death). The incidence of AARs was higher with Ultravist-370 than with Isovue-370 (0.38% vs 0.24%, P < 0.001), but only for mild AARs (0.32% vs 0.16%, P < 0.001). Analyses on risk factors indicated that female patients (n = 221, 0.43%, P < 0.001), emergency patients (n = 11, 0.51%, P < 0.001), elderly patients aged 50 to 60 years (n = 135, 0.43%, P < 0.001), and patients who underwent coronary computed tomography angiography (CTA) (n = 55, 0.51%, P < 0.001) had a higher risk of AARs. Cutaneous manifestations (50.52%)—especially rash (59.74%)—were the most frequent mild AARs. Cardiovascular manifestations accounted for most moderate and severe AARs (62.91% and 48.28%, respectively). After proper management, the symptoms and signs of 96.5% of the AARs resolved within 24 hours without sequelae. Ultravist-370 and Isovue-370 are safe for patients undergoing enhanced CT scanning. The incidence of AARs is

  17. Use of an air-assisted fuel nozzle to reduce idle emissions of a jt8d engine combustor

    NASA Technical Reports Server (NTRS)

    Papathakos, L. C.; Jones, R. E.

    1973-01-01

    Tests were performed at typical engine idle conditions on a single-can JT8D combustor installed in a 24 centimeter (9.45 in.) housing to evaluate the effect of an air-assist nozzle on reducing exhaust emissions. By injecting high-pressure air through the secondary-flow passage of a standard duplex fuel nozzle, it was possible to reduce hydrocarbon emissions from 840 parts per million to 95 parts per million and carbon monoxide emissions from 873 parts per million to 258 parts per million. NOX emissions increased slightly from 18 parts per million to 22 parts per million. An air-assist differential pressure of only 20.1 newtons per square centimeter (29.1 psi) and an airflow rate of only 0.22 percent of the total combustor airflow was required.

  18. Conductor and joint test results of JT-60SA CS and EF coils using the NIFS test facility

    NASA Astrophysics Data System (ADS)

    Obana, Tetsuhiro; Takahata, Kazuya; Hamaguchi, Shinji; Kizu, Kaname; Murakami, Haruyuki; Chikaraishi, Hirotaka; Noguchi, Hiroki; Kobuchi, Takashi; Moriuchi, Sadatomo; Imagawa, Shinsaku; Mito, Toshiyuki; Tsuchiya, Katsuhiko; Natsume, Kyohei; Yoshida, Kiyoshi; Nomoto, Kazuhiro; Kim, Tae-hyun

    2016-01-01

    In 2007, JAEA and NIFS launched the test project to evaluate the performance of cable-in-conduit (CIC) conductors and conductor joints for the JT-60SA CS and EF coils. In this project, conductor tests for four types of coil conductor and joint tests for seven types of conductor joint have been conducted for the past eight years using the NIFS test facility. As a result, the test project indicated that the CIC conductors and conductor joints fulfill the design requirement for the CS and EF coils. In addition, the NIFS test facility is expected to be utilized as the test facility for the development of a conductor and conductor joint for the purpose of the DEMO nuclear fusion power plant, provided that the required magnetic field strength is within 9 T.

  19. The results of low-speed wind tunnel tests to investigate the effects of the NASA refan JT8D engine nacelles on the stability and control characteristics of the Boeing 727-200

    NASA Technical Reports Server (NTRS)

    Shirkey, M. D.

    1973-01-01

    The results from two low-speed wind tunnel tests of the Boeing 727-200 airplane as configured with the NASA refan JT8D-109 turbofan engines are presented. The objective of these tests was to determine the effects of the refan installation on the low-speed stability and control characteristics of the 727 airplane. Four side nacelle locations were tested to insure that aerodynamic interactions of the nacelles and empennage would be optimized. The optimum location was judged to be the same as that of the production JT8D-9 engines; the current production engine mounts can be used for this location. Some small changes in the basic airplane characteristics are attributable to the refan nacelles. The flaps up longitudinal and lateral-directional stability are both slightly increased for low angles of attack and sideslip respectively. The longitudinal stability at stall is improved for both the flaps up and landing flap configurations. The high attitude characteristics of the basic airplane are not significantly altered by the refan nacelle installation. Directional control capability is not affected by the refan nacelles.

  20. The adenosine A2A receptor — Myocardial protectant and coronary target in endotoxemia

    PubMed Central

    Reichelt, Melissa E.; Ashton, Kevin J.; Tan, Xing Lin; Mustafa, S. Jamal; Ledent, Catherine; Delbridge, Lea M.D.; Hofmann, Polly A.; Headrick, John P.; Morrison, R. Ray

    2013-01-01

    Background Cardiac injury and dysfunction are contributors to disease progression and mortality in sepsis. This study evaluated the cardiovascular role of intrinsic A2A adenosine receptor (A2AAR) activity during lipopolysaccharide (LPS)-induced inflammation. Methods We assessed the impact of 24 h of LPS challenge (20 mg/kg, IP) on cardiac injury, coronary function and inflammatory mediator levels in Wild-Type (WT) mice and mice lacking functional A2AARs (A2AAR KO). Results Cardiac injury was evident in LPS-treated WTs, with ∼7-fold elevation in serum cardiac troponin I (cTnI), and significant ventricular and coronary dysfunction. Absence of A2AARs increased LPS-provoked cTnI release at 24 h by 3-fold without additional demise of contraction function. Importantly, A2AAR deletion per se emulated detrimental effects of LPS on coronary function, and LPS was without effect in coronary vessels lacking A2AARs. Effects of A2AAR KO were independent of major shifts in circulating C-reactive protein (CRP) and haptoglobin. Cytokine responses were largely insensitive to A2AAR deletion; substantial LPS-induced elevations (up to 100-fold) in IFN-γ and IL-10 were unaltered in A2AAR KO mice, as were levels of IL-4 and TNF-α. However, late elevations in IL-2 and IL-5 were differentially modulated by A2AAR KO (IL-2 reduced, IL-5 increased). Data demonstrate that in the context of LPS-triggered cardiac and coronary injury, A2AAR activity protects myocardial viability without modifying contractile dysfunction, and selectively modulates cytokine (IL-2, IL-5) release. A2AARs also appear to be targeted by LPS in the coronary vasculature. Conclusions These experimental data suggest that preservation of A2AAR functionality might provide therapeutic benefit in human sepsis. PMID:22192288

  1. Performance deterioration due to acceptance testing and flight loads; JT90 jet engine diagnostic program

    NASA Technical Reports Server (NTRS)

    Olsson, W. J.

    1982-01-01

    The results of a flight loads test of the JT9D-7 engine are presented. The goals of this test program were to: measure aerodynamic and inertia loads on the engine during flight, explore the effects of airplane gross weight and typical maneuvers on these flight loads, simultaneously measure the changes in engine running clearances and performance resulting from the maneuvers, make refinements of engine performance deterioration prediction models based on analytical results of the tests, and make recommendations to improve propulsion system performance retention. The test program included a typical production airplane acceptance test plus additional flights and maneuvers to encompass the range of flight loads in revenue service. The test results indicated that aerodynamic loads, primarily at take-off, were the major cause of rub-indicated that aerodynamic loads, primarily at take-off, were the major cause of rub-induced deterioration in the cold sectin of the engine. Differential thermal expansion between rotating and static parts plus aerodynamic loads combined to cause blade-to-seal rubs in the turbine.

  2. Performance of the JT-60SA cryogenic system under pulsed heat loads during acceptance tests

    NASA Astrophysics Data System (ADS)

    Hoa, C.; Bonne, F.; Roussel, P.; Lamaison, V.; Girard, S.; Fejoz, P.; Goncalves, R.; Vallet, J. C.; Legrand, J.; Fabre, Y.; Pudys, V.; Wanner, M.; Cardella, A.; Di Pietro, E.; Kamiya, K.; Natsume, K.; Ohtsu, K.; Oishi, M.; Honda, A.; Kashiwa, Y.; Kizu, K.

    2017-12-01

    The JT-60SA cryogenic system a superconducting tokamak currently under assembly at Naka, Japan. After one year of commissioning, the acceptance tests were successfully completed in October 2016 in close collaboration with Air Liquide Advanced Technologies (ALaT), the French atomic and alternative energies commission (CEA), Fusion for Energy (F4E) and the Quantum Radiological Science and Technology (QST). The cryogenic system has several cryogenic users at various temperatures: the superconducting magnets at 4.4 K, the current leads at 50 K, the thermal shields at 80 K and the divertor cryo-pumps at 3.7 K. The cryogenic system has an equivalent refrigeration power of about 9.5 kW at 4.5 K, with peak loads caused by the nuclear heating, the eddy currents in the structures and the AC losses in the magnets during cyclic plasma operation. The main results of the acceptance tests will be reported, with emphasis on the management of the challenging pulsed load operation using a liquid helium volume of 7 m3 as a thermal damper.

  3. Performance deterioration based on in-service engine data: JT9D jet engine diagnostics program

    NASA Technical Reports Server (NTRS)

    Sallee, G. P.

    1979-01-01

    Results of analyses of engine performance deterioration trends and levels with respect to service usage are presented. Thirty-two JT9D-7A engines were selected for this purpose. The selection of this engine fleet provided the opportunity of obtaining engine performance data starting before the first flight through initial service such that the trend and levels of engine deterioration related to both short and long term deterioration could be more carefully defined. The performance data collected and analyzed included in-flight, on wing (ground), and test stand prerepair and postrepair performance calibrations with expanded instrumentation where feasible. The results of the analyses of these data were used to: (1) close gaps in previously obtained historical data as well as augment the historical data with more carefully obtained data; (2) refine preliminary models of performance deterioration with respect to usage; (3) establish an understanding of the relationships between ground and altitude performance deterioration trends; (4) refine preliminary recommendations concerning means to reduce and control deterioration; and (5) identify areas where additional effort is required to develop an understanding of complex deterioration issues.

  4. Prediction of vapour-liquid and vapour-liquid-liquid equilibria of nitrogen-hydrocarbon mixtures used in J-T refrigerators

    NASA Astrophysics Data System (ADS)

    Narayanan, Vineed; Venkatarathnam, G.

    2018-03-01

    Nitrogen-hydrocarbon mixtures are widely used as refrigerants in J-T refrigerators operating with mixtures, as well as in natural gas liquefiers. The Peng-Robinson equation of state has traditionally been used to simulate the above cryogenic process. Multi parameter Helmholtz energy equations are now preferred for determining the properties of natural gas. They have, however, been used only to predict vapour-liquid equilibria, and not vapour-liquid-liquid equilibria that can occur in mixtures used in cryogenic mixed refrigerant processes. In this paper the vapour-liquid equilibrium of binary mixtures of nitrogen-methane, nitrogen-ethane, nitrogen-propane, nitrogen-isobutane and three component mixtures of nitrogen-methane-ethane and nitrogen-methane-propane have been studied with the Peng-Robinson and the Helmholtz energy equations of state of NIST REFPROP and compared with experimental data available in the literature.

  5. Performance deterioration based on existing (historical) data; JT9D jet engine diagnostics program

    NASA Technical Reports Server (NTRS)

    Sallee, G. P.

    1978-01-01

    The results of the collection and analysis of historical data pertaining to the deterioration of JT9D engine performance are presented. The results of analyses of prerepair and postrepair engine test stand performance data from a number of airlines to establish the individual as well as average losses in engine performance with respect to service use are included. Analysis of the changes in mechanical condition of parts, obtained by inspection of used gas-path parts of varying age, allowed preliminary assessments of component performance deterioration levels and identification of the causitive factors. These component performance estimates, refined by data from special engine back-to-back testing related to module performance restoration, permitted the development of preliminary models of engine component/module performance deterioration with respect to usage. The preliminary assessment of the causes of module performance deterioration and the trends with usage are explained, along with the role each module plays in overall engine performance deterioration. Preliminary recommendations with respect to operating and maintenance practices which could be adopted to control the level of performance deterioration are presented. The needs for additional component sensitivity testing as well as outstanding issues are discussed.

  6. Installation and pre-commissioning of the cryogenic system of JT-60SA tokamak

    NASA Astrophysics Data System (ADS)

    Hoa, C.; Michel, F.; Roussel, P.; Fejoz, P.; Girard, S.; Goncalves, R.; Lamaison, V.; Natsume, K.; Kizu, K.; Koide, Y.; Yoshida, K.; Cardella, A.; Portone, A.; Verrecchia, M.; Wanner, M.; Beauvisage, J.; Bertholat, F.; Gaillard, G.; Heloin, V.; Langevin, B.; Legrand, J.; Maire, S.; Perrier, J. M.; Pudys, V.

    2017-02-01

    The cryogenic system for the superconducting tokamak JT-60SA is currently being commissioned in Naka, Japan and shall be ready for operation in summer 2016. This contribution is part of the Broader Approach agreement between Japan and Europe. With an equivalent refrigeration capacity of about 9.5 kW at 4.5 K the cryogenic system will supply cryo-pump panels at 3.7 K, superconducting magnets and their structures at 4.4 K, high temperature superconducting current leads at 50 K and thermal shields between 80 K and 100 K. The system has been specifically designed to handle large pulse loads at 4.4 K during plasma operation. The mechanical and electrical assembly of the cryogenic system has been achieved within six months by October 2015. The main contractor Air Liquide Advanced Technology (AL-aT) have supplied eight parallel working screw compressors with a common oil removal and dryer system, a Refrigeration Cold Box and an Auxiliary Cold box with cold rotating machines. F4E has provided six GHe storage vessels and QST has provided the complete infrastructure and the facilities for the utilities. The paper gives an overview of the main design features, the infrastructure and the status of installation and pre-commissioning.

  7. A measurement of forward-flight effects on the noise from a JT15D-1 turbofan engine in the NASA-Ames 40- by 80-Foot Wind Tunnel

    NASA Technical Reports Server (NTRS)

    Ahtye, W. F.

    1980-01-01

    A Pratt and Whitney JT15D-1 turbofan engine was tested in two facilities at Ames Research Center: the outdoor Static Test Facility and the 40- by 80-Foot Wind Tunnel. The primary purposes of the test were to determine the effects of forward velocity on the turbofan spectra in the forward quadrant for the cruise inlet and to compare these wind-tunnel spectra with outdoor spectra to determine the possibility of simulating forward-velocity effects from purely outdoor measurements. The wind-tunnel data show a reduction in the blade-passage frequency tones of the order of 10 dB with increasing forward velocity at subsonic fan-tip speeds. No forward-velocity variation was observed at supersonic tip speeds. Comparison of in-duct spectra for the cruise inlet at forward velocity, with spectra from outdoor tests with a distortion-control inlet shows excellent agreement for the in-duct data when allowance is made for different in-duct volumes. This is also reflected in good agreement for the far-field spectra at small forward angles. The comparisons of wind-tunnel and outdoor data also indicate that at least for the JT15D-1, it may be possible to approximate the shape of the far-field spectra at large directivity angles from an outdoor measurement with the cruise inlet, providing an effective inflow control device is used.

  8. Cross-talk from β-Adrenergic Receptors Modulates α2A-Adrenergic Receptor Endocytosis in Sympathetic Neurons via Protein Kinase A and Spinophilin*

    PubMed Central

    Cottingham, Christopher; Lu, Roujian; Jiao, Kai; Wang, Qin

    2013-01-01

    Inter-regulation of adrenergic receptors (ARs) via cross-talk is a long appreciated but mechanistically unclear physiological phenomenon. Evidence from the AR literature and our own extensive studies on regulation of α2AARs by the scaffolding protein spinophilin have illuminated a potential novel mechanism for cross-talk from β to α2ARs. In the present study, we have characterized a mode of endogenous AR cross-talk in native adrenergic neurons whereby canonical βAR-mediated signaling modulates spinophilin-regulated α2AAR endocytosis through PKA. Our findings demonstrate that co-activation of β and α2AARs, either by application of endogenous agonist or by simultaneous stimulation with distinct selective agonists, results in acceleration of endogenous α2AAR endocytosis in native neurons. We show that receptor-independent PKA activation by forskolin is sufficient to accelerate α2AAR endocytosis and that α2AAR stimulation alone drives accelerated endocytosis in spinophilin-null neurons. Endocytic response acceleration by β/α2AAR co-activation is blocked by PKA inhibition and lost in spinophilin-null neurons, consistent with our previous finding that spinophilin is a substrate for phosphorylation by PKA that disrupts its interaction with α2AARs. Importantly, we show that α2AR agonist-mediated α2AAR/spinophilin interaction is blocked by βAR co-activation in a PKA-dependent fashion. We therefore propose a novel mechanism for cross-talk from β to α2ARs, whereby canonical βAR-mediated signaling coupled to PKA activation results in phosphorylation of spinophilin, disrupting its interaction with α2AARs and accelerating α2AAR endocytic responses. This mechanism of cross-talk has significant implications for endogenous adrenergic physiology and for therapeutic targeting of β and α2AARs. PMID:23965992

  9. Numerical modeling of a 2K J-T heat exchanger used in Fermilab Vertical Test Stand VTS-1

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Gupta, Prabhat Kumar; Rabehl, Roger

    2014-07-01

    Fermilab Vertical Test Stand-1 (VTS-1) is in operation since 2007 for testing the superconducting RF cavities at 2 K. This test stand has single layer coiled finned tubes heat exchanger before J-T valve. A finite difference based thermal model has been developed in Engineering Equation Solver (EES) to study its thermal performance during filling and refilling to maintain the constant liquid level of test stand. The model is also useful to predict its performance under other various operating conditions and will be useful to design the similar kind of heat exchanger for future needs. Present paper discusses the different operationalmore » modes of this heat exchanger and its thermal characteristics under these operational modes. Results of this model have also been compared with the experimental data gathered from the VTS-1 heat exchanger and they are in good agreement with the present model.« less

  10. Improvement of uniformity of the negative ion beams by tent-shaped magnetic field in the JT-60 negative ion source

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yoshida, Masafumi, E-mail: yoshida.masafumi@jaea.go.jp; Hanada, Masaya; Kojima, Atsushi

    2014-02-15

    Non-uniformity of the negative ion beams in the JT-60 negative ion source with the world-largest ion extraction area was improved by modifying the magnetic filter in the source from the plasma grid (PG) filter to a tent-shaped filter. The magnetic design via electron trajectory calculation showed that the tent-shaped filter was expected to suppress the localization of the primary electrons emitted from the filaments and created uniform plasma with positive ions and atoms of the parent particles for the negative ions. By modifying the magnetic filter to the tent-shaped filter, the uniformity defined as the deviation from the averaged beammore » intensity was reduced from 14% of the PG filter to ∼10% without a reduction of the negative ion production.« less

  11. Numerical analyses of baseline JT-60SA design concepts with the COREDIV code

    NASA Astrophysics Data System (ADS)

    Zagórski, R.; Gałązka, K.; Ivanova-Stanik, I.; Stępniewski, W.; Garzotti, L.; Giruzzi, G.; Neu, R.; Romanelli, M.

    2017-06-01

    JT-60SA reference design scenarios at high (#3) and low (#2) density have been analyzed with the help of the self-consistent COREDIV code. Simulations results for a standard C wall and full W wall have been compared in terms of the influence of impurities, both intrinsic (C, W) and seeded (N, Ar, Ne, Kr), on the radiation losses and plasma parameters. For scenario #3 in a C environment, the regime of detachment on divertor plates can be achieved with N or Ne seeding, whereas for the low density and high power scenario (#2), the C and seeding impurity radiation does not effectively reduce power to the targets. In this case, only an increase of either average density or edge density together with Kr seeding might help to develop conditions with strong radiation losses and semi-detached conditions in the divertor. The calculations show that, in the case of a W divertor, the power load to the plate is mitigated by seeding and the central plasma dilution is smaller compared to the C divertor. For the high density case (#3) with Ne seeding, operation in full detachment mode is predicted. Ar seems to be an optimal choice for the low-density high-power scenario #2, showing a wide operating window, whereas Ne leads to high plasma dilution at high seeding levels albeit not achieving semi-detached conditions in the divertor.

  12. Aspartic acid racemisation in purified elastin from arteries as basis for age estimation.

    PubMed

    Dobberstein, R C; Tung, S-M; Ritz-Timme, S

    2010-07-01

    Aspartic acid racemisation (AAR) results in an age-dependent accumulation of D: -aspartic acid in durable human proteins and can be used as a basis for age estimation. Routinely, age estimation based on AAR is performed by analysis of dentine. However, in forensic practise, teeth are not always available. Non-dental tissues for age estimation may be suitable for age estimation based on AAR if they contain durable proteins that can be purified and analysed. Elastin is such a durable protein. To clarify if purified elastin from arteries is a suitable sample for biochemical age estimation, AAR was determined in purified elastin from arteries from individuals of known age (n = 68 individuals, including n = 15 putrefied corpses), considering the influence of different stages of atherosclerosis and putrefaction on the AAR values. AAR was found to increase with age. The relationship between AAR and age was good enough to serve as basis for age estimation, but worse than known from dentinal proteins. Intravital and post-mortem degradation of elastin may have a moderate effect on the AAR values. Age estimation based on AAR in purified elastin from arteries may be a valuable additional tool in the identification of unidentified cadavers, especially in cases where other methods cannot be applied (e.g., no available teeth and body parts).

  13. Differential Occurrence of Interactions and Interaction Domains in Proteins Containing Homopolymeric Amino Acid Repeats

    PubMed Central

    Pelassa, Ilaria; Fiumara, Ferdinando

    2015-01-01

    Homopolymeric amino acids repeats (AARs), which are widespread in proteomes, have often been viewed simply as spacers between protein domains, or even as “junk” sequences with no obvious function but with a potential to cause harm upon expansion as in genetic diseases associated with polyglutamine or polyalanine expansions, including Huntington disease and cleidocranial dysplasia. A growing body of evidence indicates however that at least some AARs can form organized, functional protein structures, and can regulate protein function. In particular, certain AARs can mediate protein-protein interactions, either through homotypic AAR-AAR contacts or through heterotypic contacts with other protein domains. It is still unclear however, whether AARs may have a generalized, proteome-wide role in shaping protein-protein interaction networks. Therefore, we have undertaken here a bioinformatics screening of the human proteome and interactome in search of quantitative evidence of such a role. We first identified the sets of proteins that contain repeats of any one of the 20 amino acids, as well as control sets of proteins chosen at random in the proteome. We then analyzed the connectivity between the proteins of the AAR-containing protein sets and we compared it with that observed in the corresponding control networks. We find evidence for different degrees of connectivity in the different AAR-containing protein networks. Indeed, networks of proteins containing polyglutamine, polyglutamate, polyproline, and other AARs show significantly increased levels of connectivity, whereas networks containing polyleucine and other hydrophobic repeats show lower degrees of connectivity. Furthermore, we observed that numerous protein-protein, -nucleic acid, and -lipid interaction domains are significantly enriched in specific AAR protein groups. These findings support the notion of a generalized, combinatorial role of AARs, together with conventional protein interaction domains, in

  14. Magnetic shear effects on plasma transport and turbulence at high electron to ion temperature ratio in DIII-D and JT-60U plasmas

    NASA Astrophysics Data System (ADS)

    Yoshida, M.; McKee, G. R.; Murakami, M.; Grierson, B. A.; Nakata, M.; Davis, E. M.; Marinoni, A.; Ono, M.; Rhodes, T. L.; Sung, C.; Schmitz, L.; Petty, C. C.; Ferron, J. R.; Turco, F.; Garofalo, A. M.; Holcomb, C. T.; Collins, C. M.; Solomon, W. M.

    2017-05-01

    Negative magnetic shear has been demonstrated in DIII-D and JT-60U to mitigate the confinement degradation typically observed with increasing the electron to ion temperature ratio (T e/T i). In recent experiments in DIII-D negative central magnetic shear (NCS) discharges, the thermal transport in the internal transport barrier formed around the radius of the minimum safety factor (q min) remained almost constant and modestly increased in the region outside of q min compared to the positive shear (PS) case, when T e/T i increased from about 0.8 to 1.1 through electron cyclotron heating (ECH). The benefit of NCS extending into the region outside of q min can be explained by the lower magnetic shear in the NCS plasma over the plasma radius relative to the PS plasma. Reduced confinement degradation at high T e/T i with NCS plasmas was commonly observed in DIII-D and JT-60U. The mechanism of the different transport responses between the NCS and PS plasmas has been assessed in terms of fluctuation measurements and gyrokinetic simulations in DIII-D; NCS gave a smaller rise in the low-wavenumber broadband turbulent fluctuations with the increase in T e/T i compared with the PS case. This is consistent with gyrokinetic simulations, which show a smaller rise in the growth rates of the ion temperature gradient mode in the NCS plasmas, with increasing T e/T i. Gyrokinetic simulations also showed a change in the stability of the electron modes with ECH applied, consistent with higher-wavenumber fluctuation measurements, although more detailed simulations are needed to give a quantitative explanation for the experimental observations. Control of q-profile and magnetic shear will allow confinement improvement in future machines with dominant electron heating.

  15. Magnetic shear effects on plasma transport and turbulence at high electron to ion temperature ratio in DIII-D and JT-60U plasmas

    DOE PAGES

    Yoshida, Maiko; McKee, George R.; Murakami, Masanori; ...

    2017-03-30

    We demonstrated negative magnetic shear in DIII-D and JT-60U in order to mitigate the confinement degradation typically observed with increasing the electron to ion temperature ratio (T-e/T-i). In recent experiments in DIII-D negative central magnetic shear (NCS) discharges, the thermal transport in the internal transport barrier formed around the radius of the minimum safety factor (q(min)) remained almost constant and modestly increased in the region outside of q(min) compared to the positive shear (PS) case, when T-e/T-i increased from about 0.8 to 1.1 through electron cyclotron heating (ECH). The benefit of NCS extending into the region outside of qmin canmore » be explained by the lower magnetic shear in the NCS plasma over the plasma radius relative to the PS plasma. Reduced confinement degradation at high T-e/T-i with NCS plasmas was commonly observed in DIII-D and JT-60U. Furthermore, the mechanism of the different transport responses between the NCS and PS plasmas has been assessed in terms of fluctuation measurements and gyrokinetic simulations in DIII-D; NCS gave a smaller rise in the low-wavenumber broadband turbulent fluctuations with the increase in T-e/T-i compared with the PS case. This is consistent with gyrokinetic simulations, and this shows a smaller rise in the growth rates of the ion temperature gradient mode in the NCS plasmas, with increasing T-e/T-i. Gyrokinetic simulations also showed a change in the stability of the electron modes with ECH applied, consistent with higher-wavenumber fluctuation measurements, although more detailed simulations are needed to give a quantitative explanation for the experimental observations. Control of q-profile and magnetic shear will allow confinement improvement in future machines with dominant electron heating.« less

  16. Calibration of amino acid racemization (AAR) kinetics in United States mid-Atlantic Coastal Plain Quaternary mollusks using 87Sr/ 86Sr analyses: Evaluation of kinetic models and estimation of regional Late Pleistocene temperature history

    USGS Publications Warehouse

    Wehmiller, J.F.; Harris, W.B.; Boutin, B.S.; Farrell, K.M.

    2012-01-01

    The use of amino acid racemization (AAR) for estimating ages of Quaternary fossils usually requires a combination of kinetic and effective temperature modeling or independent age calibration of analyzed samples. Because of limited availability of calibration samples, age estimates are often based on model extrapolations from single calibration points over wide ranges of D/L values. Here we present paired AAR and 87Sr/ 86Sr results for Pleistocene mollusks from the North Carolina Coastal Plain, USA. 87Sr/ 86Sr age estimates, derived from the lookup table of McArthur et al. [McArthur, J.M., Howarth, R.J., Bailey, T.R., 2001. Strontium isotopic stratigraphy: LOWESS version 3: best fit to the marine Sr-isotopic curve for 0-509 Ma and accompanying Look-up table for deriving numerical age. Journal of Geology 109, 155-169], provide independent age calibration over the full range of amino acid D/L values, thereby allowing comparisons of alternative kinetic models for seven amino acids. The often-used parabolic kinetic model is found to be insufficient to explain the pattern of racemization, although the kinetic pathways for valine racemization and isoleucine epimerization can be closely approximated with this function. Logarithmic and power law regressions more accurately represent the racemization pathways for all amino acids. The reliability of a non-linear model for leucine racemization, developed and refined over the past 20 years, is confirmed by the 87Sr/ 86Sr age results. This age model indicates that the subsurface record (up to 80m thick) of the North Carolina Coastal Plain spans the entire Quaternary, back to ???2.5Ma. The calibrated kinetics derived from this age model yield an estimate of the effective temperature for the study region of 11??2??C., from which we estimate full glacial (Last Glacial Maximum - LGM) temperatures for the region on the order of 7-10??C cooler than present. These temperatures compare favorably with independent paleoclimate information

  17. MHD and resonant instabilities in JT-60SA during current ramp-up with off-axis N-NB injection

    NASA Astrophysics Data System (ADS)

    Bierwage, A.; Toma, M.; Shinohara, K.

    2017-12-01

    The excitation of magnetohydrodynamic (MHD) and resonant instabilities and their effect on the plasma profiles during the current ramp-up phase of a beam-driven JT-60SA tokamak plasma is studied using the MHD-PIC hybrid code MEGA. In the simple scenario considered, the plasma is only driven by one negative-ion-based neutral beam, depositing 500 keV deuterons at 5 MW power off-axis at about mid-radius. The beam injection starts half-way in the ramp-up phase. Within 1 s, the beam-driven plasma current and fast ion pressure produce a configuration that is strongly unstable to rapidly growing MHD and resonant modes. Using MEGA, modes with low toroidal mode numbers in the range n = 1-4 are examined in detail and shown to cause substantial changes in the plasma profiles. The necessity to develop reduced models and incorporate the effects of such instabilities in integrated codes used to simulate the evolution of entire plasma discharges is discussed.

  18. Interdependence, Reflexivity, Fidelity, Impedance Matching, and the Evolution of Genetic Coding

    PubMed Central

    Carter, Charles W; Wills, Peter R

    2018-01-01

    Abstract Genetic coding is generally thought to have required ribozymes whose functions were taken over by polypeptide aminoacyl-tRNA synthetases (aaRS). Two discoveries about aaRS and their interactions with tRNA substrates now furnish a unifying rationale for the opposite conclusion: that the key processes of the Central Dogma of molecular biology emerged simultaneously and naturally from simple origins in a peptide•RNA partnership, eliminating the epistemological utility of a prior RNA world. First, the two aaRS classes likely arose from opposite strands of the same ancestral gene, implying a simple genetic alphabet. The resulting inversion symmetries in aaRS structural biology would have stabilized the initial and subsequent differentiation of coding specificities, rapidly promoting diversity in the proteome. Second, amino acid physical chemistry maps onto tRNA identity elements, establishing reflexive, nanoenvironmental sensing in protein aaRS. Bootstrapping of increasingly detailed coding is thus intrinsic to polypeptide aaRS, but impossible in an RNA world. These notions underline the following concepts that contradict gradual replacement of ribozymal aaRS by polypeptide aaRS: 1) aaRS enzymes must be interdependent; 2) reflexivity intrinsic to polypeptide aaRS production dynamics promotes bootstrapping; 3) takeover of RNA-catalyzed aminoacylation by enzymes will necessarily degrade specificity; and 4) the Central Dogma’s emergence is most probable when replication and translation error rates remain comparable. These characteristics are necessary and sufficient for the essentially de novo emergence of a coupled gene–replicase–translatase system of genetic coding that would have continuously preserved the functional meaning of genetically encoded protein genes whose phylogenetic relationships match those observed today. PMID:29077934

  19. Titanium honeycomb acoustic lining structural and thermal test report. [for acoustic tailpipe for JT8D engine

    NASA Technical Reports Server (NTRS)

    Joynes, D.; Balut, J. P.

    1974-01-01

    The results are presented of static, fatigue and thermal testing of titanium honeycomb acoustic panels representing the acoustic tailpipe for the Pratt and Whitney Aircraft JT8D Refan engine which is being studied for use on the Boeing 727-200 airplane. Test specimens represented the engine and tailpipe flange joints, the rail to which the thrust reverser is attached and shear specimens of the tailpipe honeycomb. Specimens were made in four different batches with variations in configuration, materials and processes in each. Static strength of all test specimens exceeded the design ultimate load requirements. Fatigue test results confirmed that aluminum brazed titanium, as used in the Refan tailpipe design, meets the fatigue durability objectives. Quality of welding was found to be critical to life, with substandard welding failing prematurely, whereas welding within the process specification exceeded the panel skin life. Initial fatigue testing used short grip length bolts which failed prematurely. These were replaced with longer bolts and subsequent testing demonstrated the required life. Thermal tests indicate that perforated skin acoustic honeycomb has approximately twice the heat transfer of solid skin honeycomb.

  20. Aerodynamic performance of 0.4066-scale model of JT8D refan stage with S-duct inlet

    NASA Technical Reports Server (NTRS)

    Moore, R. D.; Kovich, G.; Lewis, G. W., Jr.

    1977-01-01

    A scale model of the JT8D refan stage was tested with a scale model of the S-duct inlet design for the refanned Boeing 727 center engine. Detailed survey data of pressures, temperatures, and flow angles were obtained over a range of flows at speeds from 70 to 97 percent of design speed. Two S-duct configurations were tested; one with a bellmouth inlet and the other with a flight lip inlet. The results indicated that the overall performance was essentially unaffected by the distortion generated by the S-duct inlet. The stall weight flow increased by less than 0.5 kg/sec (approximately 1.5% of design flow) with the S-duct inlet compared with that obtained with uniform flow. The detailed measurements indicated that the inlet guide vane (IGV) significantly reduced circumferential variations. For example, the flow angles ahead of the IGV were positive in the right half of the inlet and negative in the left half. Behind the IGV, the flow angles tended to be more uniform circumferentially.

  1. Isoproterenol Acts as a Biased Agonist of the Alpha-1A-Adrenoceptor that Selectively Activates the MAPK/ERK Pathway

    PubMed Central

    Copik, Alicja. J.; Baldys, Aleksander; Nguyen, Khanh; Sahdeo, Sunil; Ho, Hoangdung; Kosaka, Alan; Dietrich, Paul J.; Fitch, Bill; Raymond, John R.; Ford, Anthony P. D. W.; Button, Donald; Milla, Marcos E.

    2015-01-01

    The α1A-AR is thought to couple predominantly to the Gαq/PLC pathway and lead to phosphoinositide hydrolysis and calcium mobilization, although certain agonists acting at this receptor have been reported to trigger activation of arachidonic acid formation and MAPK pathways. For several G protein-coupled receptors (GPCRs) agonists can manifest a bias for activation of particular effector signaling output, i.e. not all agonists of a given GPCR generate responses through utilization of the same signaling cascade(s). Previous work with Gαq coupling-defective variants of α1A-AR, as well as a combination of Ca2+ channel blockers, uncovered cross-talk between α1A-AR and β2-AR that leads to potentiation of a Gαq-independent signaling cascade in response to α1A-AR activation. We hypothesized that molecules exist that act as biased agonists to selectively activate this pathway. In this report, isoproterenol (Iso), typically viewed as β-AR-selective agonist, was examined with respect to activation of α1A-AR. α1A-AR selective antagonists were used to specifically block Iso evoked signaling in different cellular backgrounds and confirm its action at α1A-AR. Iso induced signaling at α1A-AR was further interrogated by probing steps along the Gαq /PLC, Gαs and MAPK/ERK pathways. In HEK-293/EBNA cells transiently transduced with α1A-AR, and CHO_α1A-AR stable cells, Iso evoked low potency ERK activity as well as Ca2+ mobilization that could be blocked by α1A-AR selective antagonists. The kinetics of Iso induced Ca2+ transients differed from typical Gαq- mediated Ca2+ mobilization, lacking both the fast IP3R mediated response and the sustained phase of Ca2+ re-entry. Moreover, no inositol phosphate (IP) accumulation could be detected in either cell line after stimulation with Iso, but activation was accompanied by receptor internalization. Data are presented that indicate that Iso represents a novel type of α1A-AR partial agonist with signaling bias toward MAPK

  2. Geophysical Investigation of Upper Mantle Anomalies of the Australian-Antarctic Ridge

    NASA Astrophysics Data System (ADS)

    Park, S. H.; Choi, H.; Kim, S. S.; Lin, J.

    2017-12-01

    Australian-Antarctic Ridge (AAR) is situated between the Pacific-Antarctic Ridge (PAR) and Southeast Indian Ridge (SEIR), extending eastward from the Australian-Antarctic Discordance (AAD). Much of the AAR has been remained uncharted until 2011 because of its remoteness and harsh weather conditions. Since 2011, four multidisciplinary expeditions initiated by the Korea Polar Research Institute (KOPRI) have surveyed the little-explored eastern ends of the AAR and investigated the tectonics, geochemistry, and hydrothermal activity of this intermediate spreading system. Recent isotope studies using the new basalt samples from the AAR have led to the new hypothesis of the Southern Ocean mantle domain (SOM), which may have originated from the super-plume activity associated with the Gondwana break-up. In this study, we characterize the geophysics of the Southern Ocean mantle using the newly acquired shipboard bathymetry and available geophysical datasets. First, we computed residual mantle Bouguer gravity anomalies (RMBA), gravity-derived crustal thickness, and residual topography along the AAR in order to obtain a geological proxy for regional variations in magma supply. The results of these analyses revealed that the southern flank of the AAR is associated with shallower seafloor, more negative RMBA, thicker crust, and/or less dense mantle in comparison to the conjugate northern flank. Furthermore, this north-south asymmetry becomes more prominent toward the central ridge segments of the AAR. Interestingly, the along-axis depths of the entire AAR are significantly shallower than the neighboring ridge systems and the global ridges of intermediate spreading rates. Such shallow depths are also correlated with regional negative geoid anomalies. Furthermore, recent mantle tomography models consistently showed that the upper mantle (< 250 km) below the AAR has low S-wave velocities, suggesting that it may be hotter than the nearby ridges. Such regional-scale anomalies of the

  3. Pressure transfer function of a JT15D nozzle due to acoustic and convected entropy fluctuations

    NASA Astrophysics Data System (ADS)

    Miles, J. H.

    An acoustic transmission matrix analysis of sound propagation in a variable area duct with and without flow is extended to include convected entropy fluctuations. The boundary conditions used in the analysis are a transfer function relating entropy and pressure at the nozzle inlet and the nozzle exit impedance. The nozzle pressure transfer function calculated is compared with JT15D turbofan engine nozzle data. The one dimensional theory for sound propagation in a variable area nozzle with flow but without convected entropy is good at the low engine speeds where the nozzle exit Mach number is low (M=0.2) and the duct exit impedance model is good. The effect of convected entropy appears to be so negligible that it is obscured by the inaccuracy of the nozzle exit impedance model, the lack of information on the magnitude of the convected entropy and its phase relationship with the pressure, and the scatter in the data. An improved duct exit impedance model is required at the higher engine speeds where the nozzle exit Mach number is high (M=0.56) and at low frequencies (below 120 Hz).

  4. 75 FR 13775 - Agency Information Collection Activities: Proposed Collection; Comment Request, 1660-NEW...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-23

    ... Security Exercise and Evaluation Program (HSEEP) After Action Report (AAR) Improvement Plan (IP) AGENCY... (HSEEP) After Action Report (AAR) Improvement Plan (IP). SUMMARY: The Federal Emergency Management Agency... (HSEEP) After Action Report (AAR) Improvement Plan (IP). DATES: Comments must be submitted on or before...

  5. Surface discharge related properties of fiberglass reinforced plastic insulator for use in neutral beam injector of JT-60U.

    PubMed

    Yamano, Y; Takahashi, M; Kobayashi, S; Hanada, M; Ikeda, Y

    2008-02-01

    Neutral beam injection (NBI) used for JT-60U is required to generate negative ions of 500 keV energies. To produce such high-energy ions, three-stage electrostatic accelerators consisting of three insulator rings made of fiberglass reinforced plastic (FRP) are applied. The surface discharges along FRP insulators are one of the most serious problems in the development of NBI. To increase the hold-off voltage against surface flashover events, it is necessary to investigate the FRP insulator properties related to surface discharges in vacuum. This paper describes surface flashover characteristics for FRP and alumina samples under vacuum condition. The results show that the fold-off voltages for FRP samples are inferior to those of alumina ceramics. In addition, measurement results of surface resistivity and volume resistivity under vacuum and atmospheric conditions, secondary electron emission characteristics, and cathodoluminescence under some keV electron beam irradiation are also reported. These are important parameters to analyze surface discharge of insulators in vacuum.

  6. Surface discharge related properties of fiberglass reinforced plastic insulator for use in neutral beam injector of JT-60Ua)

    NASA Astrophysics Data System (ADS)

    Yamano, Y.; Takahashi, M.; Kobayashi, S.; Hanada, M.; Ikeda, Y.

    2008-02-01

    Neutral beam injection (NBI) used for JT-60U is required to generate negative ions of 500keV energies. To produce such high-energy ions, three-stage electrostatic accelerators consisting of three insulator rings made of fiberglass reinforced plastic (FRP) are applied. The surface discharges along FRP insulators are one of the most serious problems in the development of NBI. To increase the hold-off voltage against surface flashover events, it is necessary to investigate the FRP insulator properties related to surface discharges in vacuum. This paper describes surface flashover characteristics for FRP and alumina samples under vacuum condition. The results show that the fold-off voltages for FRP samples are inferior to those of alumina ceramics. In addition, measurement results of surface resistivity and volume resistivity under vacuum and atmospheric conditions, secondary electron emission characteristics, and cathodoluminescence under some keV electron beam irradiation are also reported. These are important parameters to analyze surface discharge of insulators in vacuum.

  7. Effects of low central fuelling on density and ion temperature profiles in reversed shear plasmas on JT-60U

    NASA Astrophysics Data System (ADS)

    Takenaga, H.; Ide, S.; Sakamoto, Y.; Fujita, T.; JT-60 Team

    2008-07-01

    Effects of low central fuelling on density and ion temperature profiles have been investigated using negative ion based neutral beam injection and electron cyclotron heating (ECH) in reversed shear plasmas on JT-60U. Strong internal transport barrier (ITB) was maintained in density and ion temperature profiles, when central fuelling was decreased by switching positive ion based neutral beam injection to ECH after the strong ITB formation. Similar density and ion temperature ITBs were formed for the low and high central fuelling cases during the plasma current ramp-up phase. Strong correlation between the density gradient and the ion temperature gradient was observed, indicating that particle transport and ion thermal transport are strongly coupled or the density gradient assists the ion temperature ITB formation through suppression of drift wave instabilities such as ion temperature gradient mode. These results support that the density and ion temperature ITBs can be formed under reactor relevant conditions.

  8. Comparison of several inflow control devices for flight simulation of fan tone noise using a JT15D-1 engine

    NASA Technical Reports Server (NTRS)

    Mcardle, J. G.; Jones, W. L.; Heidelberg, L. J.; Homyak, L.

    1980-01-01

    To enable accurate simulation of in-flight fan tone noise during ground static tests, four devices intended to reduce inflow disturbances and turbulence were tested with a JT15D-1 turbofan engine. These inflow control devices (ICD's) consisted of honeycomb/screen structures mounted over the engine inlet. The ICD's ranged from 1.6 to 4 fan diameters in size, and differed in shape and fabrication method. All the ICD's significantly reduced the BPF tone in the far-field directivity patterns, but the smallest ICD's apparently introduced propagating modes which could be recognized by additional lobes in the speeds; at supersonic fan tip speed the smallest ICD's had some measurable loss, but the largest had no loss. Data from a typical transducer show that the unsteady inflow distortion modes (turbulence) were eliminated or significantly reduced when either of the ICD's was installed. However, some steady inflow distortion modes remained.

  9. DC-9/JT8D refan, Phase 1. [technical and economic feasibility of retrofitting DC-9 aircraft with refan engine to achieve desired acoustic levels

    NASA Technical Reports Server (NTRS)

    1973-01-01

    Analyses and design studies were conducted on the technical and economic feasibility of installing the JT8D-109 refan engine on the DC-9 aircraft. Design criteria included minimum change to the airframe to achieve desired acoustic levels. Several acoustic configurations were studied with two selected for detailed investigations. The minimum selected acoustic treatment configuration results in an estimated aircraft weight increase of 608 kg (1,342 lb) and the maximum selected acoustic treatment configuration results in an estimated aircraft weight increase of 809 kg (1,784 lb). The range loss for the minimum and maximum selected acoustic treatment configurations based on long range cruise at 10 668 m (35,000 ft) altitude with a typical payload of 6 804 kg (15,000 lb) amounts to 54 km (86 n. mi.) respectively. Estimated reduction in EPNL's for minimum selected treatment show 8 EPNdB at approach, 12 EPNdB for takeoff with power cutback, 15 EPNdB for takeoff without power cutback and 12 EPNdB for sideline using FAR Part 36. Little difference was estimated in EPNL between minimum and maximum treatments due to reduced performance of maximum treatment. No major technical problems were encountered in the study. The refan concept for the DC-9 appears technically feasible and economically viable at approximately $1,000,000 per airplane. An additional study of the installation of JT3D-9 refan engine on the DC-8-50/61 and DC-8-62/63 aircraft is included. Three levels of acoustic treatment were suggested for DC-8-50/61 and two levels for DC-8-62/63. Results indicate the DC-8 technically can be retrofitted with refan engines for approximately $2,500,000 per airplane.

  10. 49 CFR 179.5 - Certificate of construction.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Executive Director—Tank Car Safety, AAR, certifying that the tank, equipment, and car fully conforms to all... Executive Director—Tank Car Safety, AAR. (c) If the owner elects to furnish service equipment, the owner shall furnish the Executive Director—Tank Car Safety, AAR, a report in prescribed form, certifying that...

  11. 49 CFR 179.5 - Certificate of construction.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Executive Director—Tank Car Safety, AAR, certifying that the tank, equipment, and car fully conforms to all... Executive Director—Tank Car Safety, AAR. (c) If the owner elects to furnish service equipment, the owner shall furnish the Executive Director—Tank Car Safety, AAR, a report in prescribed form, certifying that...

  12. 49 CFR 179.5 - Certificate of construction.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Executive Director—Tank Car Safety, AAR, certifying that the tank, equipment, and car fully conforms to all... Executive Director—Tank Car Safety, AAR. (c) If the owner elects to furnish service equipment, the owner shall furnish the Executive Director—Tank Car Safety, AAR, a report in prescribed form, certifying that...

  13. 49 CFR 179.5 - Certificate of construction.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Executive Director—Tank Car Safety, AAR, certifying that the tank, equipment, and car fully conforms to all... Executive Director—Tank Car Safety, AAR. (c) If the owner elects to furnish service equipment, the owner shall furnish the Executive Director—Tank Car Safety, AAR, a report in prescribed form, certifying that...

  14. 49 CFR 179.5 - Certificate of construction.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... to the owner and the Executive Director—Tank Car Safety, AAR, certifying that the tank, equipment... each series when submitted to the Executive Director—Tank Car Safety, AAR. (c) If the owner elects to furnish service equipment, the owner shall furnish the Executive Director—Tank Car Safety, AAR, a report...

  15. 50th Annual Fuze Conference. Session 1 and 2

    DTIC Science & Technology

    2006-05-11

    PROGRAM OFFICE AMSRD-AAR-AIJ J. Goldman X6060 STRATEGIC MGT OFFICE AMSRD-AAR-EMS D. Denery X6081 KNOWLEDGE MANAGEMENT OFFICE AMSRD-AAR-EMK G. Albinson...Tail-Mounted Configuration (MK-82 Demo) UHF to L-Band Pulse Doppler Radar Using Low Cost COTS Components Nose and Tail Mount Configurations Only

  16. Free-flying dynamics and control of an astronaut assistant robot based on fuzzy sliding mode algorithm

    NASA Astrophysics Data System (ADS)

    Gao, Qing; Liu, Jinguo; Tian, Tongtong; Li, Yangmin

    2017-09-01

    Space robots can perform some tasks in harsh environment as assistants of astronauts or substitutions of astronauts. Taking the limited working time and the arduous task of the astronauts in the space station into account, an astronaut assistant robot (AAR-2) applied in the space station is proposed and designed in this paper. The AAR-2 is achieved with some improvements on the basis of AAR-1 which was designed before. It can exploit its position and attitude sensors and control system to free flight or hover in the space cabin. And it also has a definite environmental awareness and artificial intelligence to complete some specified tasks under the control of astronauts or autonomously. In this paper, it mainly analyzes and controls the 6-DOF motion of the AAR-2. Firstly, the system configuration of AAR-2 is specifically described, and the movement principles are analyzed. Secondly, according to the physical model of the AAR-2, the Newton - Euler equation is applied in the preparation of space dynamics model of 6-DOF motion. Then, according to the mathematical model's characteristics which are nonlinear and strong coupling, a dual closed loop position and attitude controller based on fuzzy sliding mode control is proposed and designed. Finally, simulation experiments are appropriate to provide for AAR-2 control system by using Matlab/Simulink. From the simulation results it can be observed that the designed fuzzy sliding mode controller can control the 6-DOF motion of AAR-2 quickly and precisely.

  17. 49 CFR 232.603 - Design, interoperability, and configuration management requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...: 1999; Revised 2002, 2007); (3) AAR S-4220, “ECP Cable-Based Brake DC Power Supply—Performance...; Revised: 2004); (7) AAR S-4260, “ECP Brake and Wire Distributed Power Interoperability Test Procedures...) Approval. A freight train or freight car equipped with an ECP brake system and equipment covered by the AAR...

  18. Dynamics of energetic particle driven modes and MHD modes in wall-stabilized high-β plasmas on JT-60U and DIII-D

    NASA Astrophysics Data System (ADS)

    Matsunaga, G.; Okabayashi, M.; Aiba, N.; Boedo, J. A.; Ferron, J. R.; Hanson, J. M.; Hao, G. Z.; Heidbrink, W. W.; Holcomb, C. T.; In, Y.; Jackson, G. L.; Liu, Y. Q.; Luce, T. C.; McKee, G. R.; Osborne, T. H.; Pace, D. C.; Shinohara, K.; Snyder, P. B.; Solomon, W. M.; Strait, E. J.; Turnbull, A. D.; Van Zeeland, M. A.; Watkins, J. G.; Zeng, L.; the DIII-D Team; the JT-60 Team

    2013-12-01

    In the wall-stabilized high-β plasmas in JT-60U and DIII-D, interactions between energetic particle (EP) driven modes (EPdMs) and edge localized modes (ELMs) have been observed. The interaction between the EPdM and ELM are reproducibly observed. Many EP diagnostics indicate a strong correlation between the distorted waveform of the EPdM and the EP transport to the edge. The waveform distortion is composed of higher harmonics (n ⩾ 2) and looks like a density snake near the plasma edge. According to statistical analyses, ELM triggering by the EPdMs requires a finite level of waveform distortion and pedestal recovery. ELM pacing by the EPdMs occurs when the repetition frequency of the EPdMs is higher than the natural ELM frequency. EPs transported by EPdMs are thought to contribute to change the edge stability.

  19. ADRA2A is involved in neuro-endocrine regulation of bone resorption.

    PubMed

    Mlakar, Vid; Jurkovic Mlakar, Simona; Zupan, Janja; Komadina, Radko; Prezelj, Janez; Marc, Janja

    2015-07-01

    Adrenergic stimulation is important for osteoclast differentiation and bone resorption. Previous research shows that this happens through β2-adrenergic receptor (AR), but there are conflicting evidence on presence and role of α2A-AR in bone. The aim of this study was to investigate the presence of α2A-AR and its involvement in neuro-endocrine signalling of bone remodelling in humans. Real-time polymerase chain reaction (PCR) and immunohistochemistry were used to investigate α2A-AR receptor presence and localization in bone cells. Functionality of rs553668 and rs1800544 single nucleotide polymorphism SNPs located in α2A-AR gene was analysed by qPCR expression on bone samples and luciferase reporter assay in human osteosarcoma HOS cells. Using real-time PCR, genetic association study between rs553668 A>G and rs1800544 C>G SNPs and major bone markers was performed on 661 Slovenian patients with osteoporosis. α2A-AR is expressed in osteoblasts and lining cells but not in osteocytes. SNP rs553668 has a significant influence on α2A-AR mRNA level in human bone samples through the stability of mRNA. α2A-AR gene locus associates with important bone remodelling markers (BMD, CTX, Cathepsin K and pOC). The results of this study are providing comprehensive new evidence that α2A-AR is involved in neuro-endocrine signalling of bone turnover and development of osteoporosis. As shown by our results the neurological signalling is mediated through osteoblasts and result in bone resorption. Genetic study showed association of SNPs in α2A-AR gene locus with bone remodelling markers, identifying the individuals with higher risk of development of osteoporosis. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  20. ADRA2A is involved in neuro-endocrine regulation of bone resorption

    PubMed Central

    Mlakar, Vid; Jurkovic Mlakar, Simona; Zupan, Janja; Komadina, Radko; Prezelj, Janez; Marc, Janja

    2015-01-01

    Adrenergic stimulation is important for osteoclast differentiation and bone resorption. Previous research shows that this happens through β2-adrenergic receptor (AR), but there are conflicting evidence on presence and role of α2A-AR in bone. The aim of this study was to investigate the presence of α2A-AR and its involvement in neuro-endocrine signalling of bone remodelling in humans. Real-time polymerase chain reaction (PCR) and immunohistochemistry were used to investigate α2A-AR receptor presence and localization in bone cells. Functionality of rs553668 and rs1800544 single nucleotide polymorphism SNPs located in α2A-AR gene was analysed by qPCR expression on bone samples and luciferase reporter assay in human osteosarcoma HOS cells. Using real-time PCR, genetic association study between rs553668 A>G and rs1800544 C>G SNPs and major bone markers was performed on 661 Slovenian patients with osteoporosis. α2A-AR is expressed in osteoblasts and lining cells but not in osteocytes. SNP rs553668 has a significant influence on α2A-AR mRNA level in human bone samples through the stability of mRNA. α2A-AR gene locus associates with important bone remodelling markers (BMD, CTX, Cathepsin K and pOC). The results of this study are providing comprehensive new evidence that α2A-AR is involved in neuro-endocrine signalling of bone turnover and development of osteoporosis. As shown by our results the neurological signalling is mediated through osteoblasts and result in bone resorption. Genetic study showed association of SNPs in α2A-AR gene locus with bone remodelling markers, identifying the individuals with higher risk of development of osteoporosis. PMID:25818344

  1. Detailed in situ laser calibration of the infrared imaging video bolometer for the JT-60U tokamak

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Parchamy, H.; Peterson, B. J.; Konoshima, S.

    2006-10-15

    The infrared imaging video bolometer (IRVB) in JT-60U includes a single graphite-coated gold foil with an effective area of 9x7 cm{sup 2} and a thickness of 2.5 {mu}m. The thermal images of the foil resulting from the plasma radiation are provided by an IR camera. The calibration technique of the IRVB gives confidence in the absolute levels of the measured values of the plasma radiation. The in situ calibration is carried out in order to obtain local foil properties such as the thermal diffusivity {kappa} and the product of the thermal conductivity k and the thickness t{sub f} of themore » foil. These quantities are necessary for solving the two-dimensional heat diffusion equation of the foil which is used in the experiments. These parameters are determined by comparing the measured temperature profiles (for kt{sub f}) and their decays (for {kappa}) with the corresponding results of a finite element model using the measured HeNe laser power profile as a known radiation power source. The infrared camera (Indigo/Omega) is calibrated by fitting the temperature rise of a heated plate to the resulting camera data using the Stefan-Boltzmann law.« less

  2. Forebrain pathway for auditory space processing in the barn owl.

    PubMed

    Cohen, Y E; Miller, G L; Knudsen, E I

    1998-02-01

    The forebrain plays an important role in many aspects of sound localization behavior. Yet, the forebrain pathway that processes auditory spatial information is not known for any species. Using standard anatomic labeling techniques, we used a "top-down" approach to trace the flow of auditory spatial information from an output area of the forebrain sound localization pathway (the auditory archistriatum, AAr), back through the forebrain, and into the auditory midbrain. Previous work has demonstrated that AAr units are specialized for auditory space processing. The results presented here show that the AAr receives afferent input from Field L both directly and indirectly via the caudolateral neostriatum. Afferent input to Field L originates mainly in the auditory thalamus, nucleus ovoidalis, which, in turn, receives input from the central nucleus of the inferior colliculus. In addition, we confirmed previously reported projections of the AAr to the basal ganglia, the external nucleus of the inferior colliculus (ICX), the deep layers of the optic tectum, and various brain stem nuclei. A series of inactivation experiments demonstrated that the sharp tuning of AAr sites for binaural spatial cues depends on Field L input but not on input from the auditory space map in the midbrain ICX: pharmacological inactivation of Field L eliminated completely auditory responses in the AAr, whereas bilateral ablation of the midbrain ICX had no appreciable effect on AAr responses. We conclude, therefore, that the forebrain sound localization pathway can process auditory spatial information independently of the midbrain localization pathway.

  3. Measurement of Neutral Temperature in the 120-180 Km Region of the Atmosphere Following TMA Releases from a Rocket.

    DTIC Science & Technology

    1979-05-01

    010590 C ..----------------------------------------------------------------------- 010590 C 010600 DIMENSION WACC (20),MAKK(20).AA(20).AM(20),F(19...011670 62 YIUVACC(JT-1) 011680 Y2- WACC (JT 1011690) Y3-UACC( JT+1) 011700 00 TO 64 01t710 63 Y1-WAKK(JT-1) 011720 Y2-WAKK(JT 1011730 Y3-WAKK(JT+1

  4. Age estimation based on aspartic acid racemization in elastin from the yellow ligaments.

    PubMed

    Ritz-Timme, S; Laumeier, I; Collins, M

    2003-04-01

    The yellow ligaments of the spine are characterized by an exceptionally high content of elastin, a protein with a proved longevity in several human tissues. This unique biochemical composition suggested a suitability of yellow ligaments for age estimation based on aspartic acid racemization (AAR), which was tested by determination of AAR in total tissue specimens and in purified elastin from yellow ligaments of individuals of known age. AAR was found to increase with age in both sample sets. The purified elastin samples exhibited a much faster kinetics than the total tissue, with ca. 3.7-4.6-fold higher apparent rates. The relationship between AAR and age was much closer in the purified elastin samples ( r=0.96-0.99) and it can therefore be used as a basis for biochemical age estimation. The analysis of total tissue samples cannot be recommended since the AAR values can be strongly influenced even by slight, histologically non-detectable variations in the collagen content. Age estimation based on AAR in purified elastin from yellow ligaments may be a valuable additional tool in the identification of unidentified cadavers, especially in cases where other methods cannot be applied (e.g. no available teeth, body parts).

  5. Air Force Procedure for Predicting Aircraft Noise Around Airbases: Airbase Operations Program (BASEOPS) Description

    DTIC Science & Technology

    1990-01-01

    B720B/JT3D-3 JCOM 2 JT3D 9 51 52 53 54 55 0 0 12 DC850 DC-8-50/JT3D-3 JCOM 2 JT3D 10 56 57 58 59 60 61 0 13 DC860 DC-8- 60 /JT30-7 JCOM 2 JT3D 11 62 63 64...B707-320B/JT30-7QN JCOM 3 JT3DQ 8 38 39 40 41 42 43 44 17 DCBQN DC-8- 60 /JT30-70N JCOM 3 JT3DQ 10 62 63 64 65 66 67 68 18 CONCRD CONCORDE/OLY593 JCOM...8 0LY593 14 83 83 83 83 84 84 0 19 DC1010 DC-10-10/CF6- 60 JCOM 11 CF660 15 85 86 87 88 89 90 0 20 DC1030 DC-10-30/CF6-50C2 JCOM 11 CF660 58 203 204

  6. Aminostratigraphy of Subsurface Units, Eastern Albemarle Sound and Northern Outer Banks, North Carolina

    NASA Astrophysics Data System (ADS)

    Wehmiller, J. F.; Thieler, E. R.; York, L. L.; Pellerito, V.

    2002-12-01

    The Quaternary geochronology of subsurface and emergent units on the US Atlantic Coastal Plain aids the understanding of the geologic framework that affects Holocene coastal processes. Amino acid racemization (AAR) and radiocarbon results for mollusk samples from a variety of sampling sites along the NC coastal plain contribute to this chronologic framework. Recent drilling on the northern Outer Banks has yielded AAR/14C results that are compared with existing data for samples from nearby inner shelf or beach sites, or from subsurface sampling in mainland Dare County (Riggs and others, 1992). AAR data serve to delineate stratigraphic units; suitably calibrated, AAR data can be used to estimate ages for units with no independent radiometric data. New AAR data from two holes, OBX-5 and OBX-8 (north and central portions of cross-section D-D' of Riggs et al., 1992), identify three pre-Holocene aminozones. The oldest one (OBX-5, 135' depth) corresponds to an early/middle Pleistocene aminozone (AZ-4) seen in other subsurface sections in the region (Riggs et al., 1992). Based on AAR, AZ-4 is approximately 2/3 the age of the James City Formation, a mapped early Pleistocene unit exposed in central NC. Two younger aminozones are seen in superposition in OBX-8, at 65' and 114'. These aminozones have D/L values that are slightly greater than those seen in AZ-2 and AZ-3, interpreted as late and late/middle Pleistocene (Riggs et al., 1992), respectively. Infinite or near-infinite 14C dates at depths between 65' and 104' in OBX-8 confirm the Pleistocene age assignment based on AAR. Radiocarbon and AAR constrain the boundary between the early Holocene and AZ-4 (early/middle Pleistocene) in OBX-5 to an interval between ca. 110' and 135' depth; intervening late Pleistocene strata may be present but are not identified based on chronologic data. Paired 14C/AAR analysis of reworked/transported beach or shelf shell in the region supports the relative ages seen in the OBX holes and

  7. Chapter K: Progress in the Evaluation of Alkali-Aggregate Reaction in Concrete Construction in the Pacific Northwest, United States and Canada

    USGS Publications Warehouse

    Shrimer, Fred H.

    2005-01-01

    The supply of aggregates suitable for use in construction and maintenance of infrastructure in western North America is a continuing concern to the engineering and resources-management community. Steady population growth throughout the region has fueled demand for high-quality aggregates, in the face of rapid depletion of existing aggregate resources and slow and difficult permitting of new sources of traditional aggregate types. In addition to these challenges, the requirement for aggregates to meet various engineering standards continues to increase. In addition to their physical-mechanical properties, other performance characteristics of construction aggregates specifically depend on their mineralogy and texture. These properties can result in deleterious chemical reactions when aggregate is used in concrete mixes. When this chemical reaction-termed 'alkali-aggregate reaction' (AAR)-occurs, it can pose a major problem for concrete structures, reducing their service life and requiring expensive repair or even replacement of the concrete. AAR is thus to be avoided in order to promote the longevity of concrete structures and to ensure that public moneys invested in infrastructure are well spent. Because the AAR phenomenon is directly related to the mineral composition, texture, and petrogenesis of the rock particles that make up aggregates, an understanding of the relation between the geology and the performance of aggregates in concrete is important. In the Pacific Northwest, some aggregates have a moderate to high AAR potential, but many others have no or only a low AAR potential. Overall, AAR is not as widespread or serious a problem in the Pacific Northwest as in other regions of North America. The identification of reactive aggregates in the Pacific Northwest and the accurate prediction of their behavior in concrete continue to present challenges for the assessment and management of geologic resources to the owners and operators of pits and quarries and to the

  8. Studies on impact of electron cyclotron wave injection on the internal transport barriers in JT-60U weak shear plasmas

    NASA Astrophysics Data System (ADS)

    Ide, S.; Takenaga, H.; Isayama, A.; Sakamoto, Y.; Yoshida, M.; Gormezano, C.

    2007-11-01

    Impact of the electron cyclotron range of frequency wave (ECRF) on the internal transport barriers (ITBs) in a weak shear (WS) plasma has been investigated in JT-60U. The fundamental O-mode ECRF of 110 GHz injected obliquely (co-current drive) from the low field side is used. It is observed that the ion temperature (Ti) ITB in a WS plasma can be degraded by ECRF. It is clarified for the first time that the degradation depends increasingly on the EC power (PEC) but decreasingly on the plasma current (Ip). Moreover it is confirmed that ECRF affects the toroidal rotation (Vt) indirectly and results in the flattening of Vt(ρ) and therefore the radial electric field (Er) profiles regardless of the direction of the target Vt(ρ), peaking co or counter direction (relative to the Ip direction). Furthermore, it is recently found that Ti and Vt in the whole ITB region are affected with almost no delay from the EC onset even with off-axis EC deposition. These results indicate that EC injection unveiled a semi-global structure that characterizes Ti ITB in a WS plasma.

  9. Wound healing efficacy of Jatyadi Taila: in vivo evaluation in rat using excision wound model.

    PubMed

    Shailajan, Sunita; Menon, Sasikumar; Pednekar, Suhas; Singh, Ashish

    2011-10-31

    In traditional Indian medicinal treatise there are several Ayurvedic formulations mentioned which have been claimed as potential wound healing agents like Madhu Ghrita and Jatyadi Taila. Jatyadi Taila (JT) is a medicated oil formulation (Taila) popularly used in the treatment of various topical wounds. Though JT has its composition recorded in ancient Ayurvedic texts, there have been minimal attempts to standardize its use in the management of wound. The current work evaluates the wound healing efficacy of JT and also provides evidence of the dermal absorption kinetics of Karanjin from JT. JT was subjected to preliminary phytochemical evaluation. Therapeutically active marker components β-sitosterol, lupeol and karanjin were detected and separated using HPTLC. As a part of safety evaluation, skin irritation potential of JT was evaluated on rabbit skin. Excision wound model in rats were used to evaluate the wound healing efficacy of JT. Histopathological and biochemical evaluations of excised skin tissues at wound sites were carried out. The HPTLC method developed was also validated to evaluate the pharmacokinetics of Karanjin from JT after topical application on pinna of rabbit. Preliminary phytochemical evaluation of JT revealed presence of flavonoids, essential oils, tannins, glycosides, steroids and alkaloids while resins were found to be absent. HPTLC confirmed the presence of karanjin, lupeol and β-sitosterol in JT. JT was found to be non-irritant when applied to the skin of rabbits. Topical application of JT on excision wounds caused significantly faster reduction in wound area as compared to the application of modern topical formulation (Neosporin(®)) and untreated control wounds. Animals treated with JT showed significant increase in protein, hydroxyproline and hexosamine content in the granulation tissue when compared with the untreated controls. Wound healing potential of JT was found to be dose dependant. HPTLC method was successfully used to evaluate

  10. Comparison of Dispersion Model of Magneto-Acoustic Cyclotron Instability with Experimental Observation of 3He Ion Cyclotron Emission on JT-60U

    NASA Astrophysics Data System (ADS)

    Sumida, Shuhei; Shinohara, Kouji; Ikezoe, Ryuya; Ichimura, Makoto; Sakamoto, Mizuki; Hirata, Mafumi; Ide, Shunsuke

    2017-12-01

    The Magneto-acoustic Cyclotron Instability (MCI) is a possible emission mechanism for Ion Cyclotron Emissions (ICEs). A dispersion model of the MCI driven by a drifting-ring-type ion velocity distribution has been proposed. In this study, the model was compared with the experimental observations of 3He ICEs [ICEs(3He)] on JT-60U. For this purpose, at first, velocity distributions of deuterium-deuterium fusion produced fast 3He ions at the time of an appearance of the ICE(3He) were evaluated by using a fast ion orbit following code under a realistic condition. The calculated distribution at the edge of the plasma on the midplane on the low field side is shown to have an inverted population and strong anisotropy. This distribution can be reasonably approximated by the drifting-ring-type distribution. Next, dispersions of the MCIs driven by the drifting-ring-type distribution were compared with those of observed ICEs(3He). The comparison shows that toroidal wavenumbers and frequencies of the calculated MCIs agree with those of the observed ICEs(3He).

  11. Effect of resistivity profile on current decay time of initial phase of current quench in neon-gas-puff inducing disruptions of JT-60U

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kawakami, S.; Ohno, N.; Shibata, Y.

    2013-11-15

    According to an early work [Y. Shibata et al., Nucl. Fusion 50, 025015 (2010)] on the behavior of the plasma current decay in the JT-60U disruptive discharges caused by the radiative collapse with a massive neon-gas-puff, the increase of the internal inductance mainly determined the current decay time of plasma current during the initial phase of current quench. To investigate what determines the increase of the internal inductance, we focus attention on the relationship between the electron temperature (or the resistivity) profile and the time evolution of the current density profile and carry out numerical calculations. As a result, wemore » find the reason of the increase of the internal inductance: The current density profile at the start of the current quench is broader than an expected current density profile in the steady state, which is determined by the temperature (or resistivity) profile. The current density profile evolves into peaked one and the internal inductance is increasing.« less

  12. Psychophysiological Assessment in Pilots Performing Challenging Simulated and Real Flight Maneuvers.

    PubMed

    Johannes, Bernd; Rothe, Stefanie; Gens, André; Westphal, Soeren; Birkenfeld, Katja; Mulder, Edwin; Rittweger, Jörn; Ledderhos, Carla

    2017-09-01

    The objective assessment of psychophysiological arousal during challenging flight maneuvers is of great interest to aerospace medicine, but remains a challenging task. In the study presented here, a vector-methodological approach was used which integrates different psychophysiological variables, yielding an integral arousal index called the Psychophysiological Arousal Value (PAV). The arousal levels of 15 male pilots were assessed during predetermined, well-defined flight maneuvers performed under simulated and real flight conditions. The physiological data, as expected, revealed inter- and intra-individual differences for the various measurement conditions. As indicated by the PAV, air-to-air refueling (AAR) turned out to be the most challenging task. In general, arousal levels were comparable between simulator and real flight conditions. However, a distinct difference was observed when the pilots were divided by instructors into two groups based on their proficiency in AAR with AWACS (AAR-Novices vs. AAR-Professionals). AAR-Novices had on average more than 2000 flight hours on other aircrafts. They showed higher arousal reactions to AAR in real flight (contact: PAV score 8.4 ± 0.37) than under simulator conditions (7.1 ± 0.30), whereas AAR-Professionals did not (8.5 ± 0.46 vs. 8.8 ± 0.80). The psychophysiological arousal value assessment was tested in field measurements, yielding quantifiable arousal differences between proficiency groups of pilots during simulated and real flight conditions. The method used in this study allows an evaluation of the psychophysiological cost during a certain flying performance and thus is possibly a valuable tool for objectively evaluating the actual skill status of pilots.Johannes B, Rothe S, Gens A, Westphal S, Birkenfeld K, Mulder E, Rittweger J, Ledderhos C. Psychophysiological assessment in pilots performing challenging simulated and real flight maneuvers. Aerosp Med Hum Perform. 2017; 88(9):834-840.

  13. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lopez-Buendia, A.M.; Climent, V.; Verdu, P.

    The reactivity of carbonate rock with the alkali content of cement, commonly called alkali-carbonate reaction (ACR), has been investigated. Alkali-silica reaction (ASR) can also contribute in the alkali-aggregate reaction (AAR) in carbonate rock, mainly due to micro- and crypto-crystalline quartz or clay content in carbonate aggregate. Both ACR and ASR can occur in the same system, as has been also evidenced on this paper. Carbonate aggregate samples were selected using lithological reactivity criteria, taking into account the presence of dedolomitization, partial dolomitization, micro- and crypto-crystalline quartz. Selected rocks include calcitic dolostone with chert (CDX), calcitic dolostone with dedolomitization (CDD), limestonemore » with chert (LX), marly calcitic dolostone with partial dolomitization (CD), high-porosity ferric dolostone with clays (FD). To evaluate the reactivity, aggregates were studied using expansion tests following RILEM AAR-2, AAR-5, a modification using LiOH AAR-5Li was also tested. A complementary study was done using petrographic monitoring with polarised light microscopy on aggregates immersed in NaOH and LiOH solutions after different ages. SEM-EDAX has been used to identify the presence of brucite as a product of dedolomitization. An ACR reaction showed shrinkage of the mortar bars in alkaline solutions explained by induced dedolomitization, while an ASR process typically displayed expansion. Neither shrinkage nor expansion was observed when mortar bars were immersed in solutions of lithium hydroxide. Carbonate aggregate classification with AAR pathology risk has been elaborated based on mechanical behaviours by expansion and shrinkage. It is proposed to be used as a petrographic method for AAR diagnosis to complement the RILEM AAR1 specifically for carbonate aggregate. Aggregate materials can be classified as I (non-reactive), II (potentially reactive), and III (probably reactive), considering induced dedolomitization ACR

  14. A feasibility study evaluating effectiveness of an intervention to implement brief tobacco cessation counseling in community chain pharmacies

    PubMed Central

    Patwardhan, Pallavi D.; Chewning, Betty A.

    2016-01-01

    Objective To test the feasibility of implementing ask-advise-refer (AAR) in representative community chain pharmacies serving low socioeconomic areas, and to assess the effectiveness of a multimodal intervention on short-term implementation of AAR. Design Randomized controlled trial Settings Sixteen community chain pharmacies in South-central Wisconsin Intervention A multimodal intervention including: 1) training to implement AAR, 2) workflow integration recommendations, 3) a cessation poster to create awareness, and 4) a support visit. Main outcome measures Number of patrons asked about their tobacco use, number of tobacco users advised to quit, number of quitline cards given, and number of tobacco users enrolled in the quitline. Results As hypothesized, the multimodal intervention significantly predicted the number of patrons asked (estimate=4.84, incidence rate ratios[IRR]=127.2; p<0.001) tobacco users advised (estimate=2.12, IRR=8.33; p<0.01), quitline cards distributed (estimate=1.04, IRR=2.82; p<0.05), and tobacco users enrolled in the quitline (estimate=2.31, IRR=10.13; p<0.001). Conclusion This trial demonstrates the feasibility of implementing AAR in routine community pharmacy practice. This trial also indicates the short-term effectiveness of the intervention in facilitating AAR, implementation in partnership with other public health services and systems. More research is needed to evaluate the generalizability, effectiveness and sustainability of AAR, including factors influencing adoption and the impact on cessation. PMID:22825231

  15. Methods for Kinetic and Thermodynamic Analysis of Aminoacyl-tRNA Synthetases

    PubMed Central

    Francklyn, Christopher S.; First, Eric A.; Perona, John J.; Hou, Ya-Ming

    2008-01-01

    The accuracy of protein synthesis relies on the ability of aminoacyl-tRNA synthetases (aaRSs) to discriminate among true and near cognate substrates. To date, analysis of aaRSs function, including identification of residues of aaRS participating in amino acid and tRNA discrimination, has largely relied on the steady state kinetic pyrophosphate exchange and aminoacylation assays. Pre-steady state kinetic studies investigating a more limited set of aaRS systems have also been undertaken to assess the energetic contributions of individual enzyme-substrate interactions, particularly in the adenylation half reaction. More recently, a renewed interest in the use of rapid kinetics approaches for aaRSs has led to their application to several new aaRS systems, resulting in the identification of mechanistic differences that distinguish the two structurally distinct aaRS classes. Here, we review the techniques for thermodynamic and kinetic analysis of aaRS function. Following a brief survey of methods for the preparation of materials and for steady state kinetic analysis, this review will describe pre-steady state kinetic methods employing rapid quench and stopped-flow fluorescence for analysis of the activation and aminoacyl transfer reactions. Application of these methods to any aaRS system allows the investigator to derive detailed kinetic mechanisms for the activation and aminoacyl transfer reactions, permitting issues of substrate specificity, stereochemical mechanism, and inhibitor interaction to be addressed in a rigorous and quantitative fashion. PMID:18241792

  16. Cluster in the Auroral Acceleration Region

    NASA Technical Reports Server (NTRS)

    Pickett, Jolene S.; Fazakerley, Andrew N.; Marklund, Gorun; Dandouras, Iannis; Christopher, Ivar W.; Kistler, Lynn; Lucek, Elizabeth; Masson, Arnaud; Taylor, Matthew G.; Mutel, Robert L.; hide

    2010-01-01

    Due to a fortuitous evolution of the Cluster orbit, the Cluster spacecraft penetrated for the first time in its mission the heart of Earth's auroral acceleration region (AAR) in December 2009 and January 2010. During this time a special AAR campaign was carried out by the various Cluster instrument teams with special support from ESA and NASA facilities. We present some of the first multi-spacecraft observations of the waves, particles and fields made during that campaign. The Cluster spacecraft configuration during these AAR passages was such that it allowed us to explore the differences in the signatures of waves, particles, and fields on the various spacecraft in ways not possible with single spacecraft. For example, one spacecraft was more poleward than the other three (C2), one was at higher altitude (C1), and one of them (0) followed another (C4) through the AAR on approximately the same track but delayed by three minutes. Their separations were generally on the order of a few thousand km or less and occasionally two of them were lying along the same magnetic field line. We will show some of the first analyses of the data obtained during the AAR campaign, where upward and downward current regions, and the waves specifically associated with those regions, as well as the auroral cavities, were observed similarly and differently on the various spacecraft, helping us to explore the spatial, as well as the temporal, aspects of processes occurring in the AAR.

  17. Structure-Activity Relationships of Truncated C2- or C8-Substituted Adenosine Derivatives as Dual Acting A2A and A3 Adenosine Receptor Ligands

    PubMed Central

    Hou, Xiyan; Majik, Mahesh S.; Kim, Kyunglim; Pyee, Yuna; Lee, Yoonji; Alexander, Varughese; Chung, Hwa-Jin; Lee, Hyuk Woo; Chandra, Girish; Lee, Jin Hee; Park, Seul-gi; Choi, Won Jun; Kim, Hea Ok; Phan, Khai; Gao, Zhan-Guo; Jacobson, Kenneth A.; Choi, Sun; Lee, Sang Kook; Jeong, Lak Shin

    2011-01-01

    Truncated N6-substituted-4′-oxo- and 4′-thioadenosine derivatives with C2 or C8 substitution were studied as dual acting A2A and A3 adenosine receptor (AR) ligands. The lithiation-mediated stannyl transfer and palladium-catalyzed cross coupling reactions were utilized for functionalization of the C2 position of 6-chloropurine nucleosides. An unsubstituted 6-amino group and a hydrophobic C2 substituent were required for high affinity at the hA2AAR, but hydrophobic C8 substitution abolished binding at the hA2AAR. However, most of synthesized compounds displayed medium to high binding affinity at the hA3AR, regardless of C2 or C8 substitution, and low efficacy in a functional cAMP assay. Several compounds tended to be full hA2AAR agonists. C2 substitution probed geometrically through hA2AAR-docking, was important for binding in order of hexynyl > hexenyl > hexanyl. Compound 4g was the most potent ligand acting dually as hA2AAR agonist and hA3AR antagonist, which might be useful for treatment of asthma or other inflammatory diseases. PMID:22142423

  18. Amino acid repeats avert mRNA folding through conservative substitutions and synonymous codons, regardless of codon bias.

    PubMed

    Barik, Sailen

    2017-12-01

    A significant number of proteins in all living species contains amino acid repeats (AARs) of various lengths and compositions, many of which play important roles in protein structure and function. Here, I have surveyed select homopolymeric single [(A)n] and double [(AB)n] AARs in the human proteome. A close examination of their codon pattern and analysis of RNA structure propensity led to the following set of empirical rules: (1) One class of amino acid repeats (Class I) uses a mixture of synonymous codons, some of which approximate the codon bias ratio in the overall human proteome; (2) The second class (Class II) disregards the codon bias ratio, and appears to have originated by simple repetition of the same codon (or just a few codons); and finally, (3) In all AARs (including Class I, Class II, and the in-betweens), the codons are chosen in a manner that precludes the formation of RNA secondary structure. It appears that the AAR genes have evolved by orchestrating a balance between codon usage and mRNA secondary structure. The insights gained here should provide a better understanding of AAR evolution and may assist in designing synthetic genes.

  19. Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands.

    PubMed

    Hou, Xiyan; Majik, Mahesh S; Kim, Kyunglim; Pyee, Yuna; Lee, Yoonji; Alexander, Varughese; Chung, Hwa-Jin; Lee, Hyuk Woo; Chandra, Girish; Lee, Jin Hee; Park, Seul-Gi; Choi, Won Jun; Kim, Hea Ok; Phan, Khai; Gao, Zhan-Guo; Jacobson, Kenneth A; Choi, Sun; Lee, Sang Kook; Jeong, Lak Shin

    2012-01-12

    Truncated N(6)-substituted-4'-oxo- and 4'-thioadenosine derivatives with C2 or C8 substitution were studied as dual acting A(2A) and A(3) adenosine receptor (AR) ligands. The lithiation-mediated stannyl transfer and palladium-catalyzed cross-coupling reactions were utilized for functionalization of the C2 position of 6-chloropurine nucleosides. An unsubstituted 6-amino group and a hydrophobic C2 substituent were required for high affinity at the hA(2A)AR, but hydrophobic C8 substitution abolished binding at the hA(2A)AR. However, most of synthesized compounds displayed medium to high binding affinity at the hA(3)AR, regardless of C2 or C8 substitution, and low efficacy in a functional cAMP assay. Several compounds tended to be full hA(2A)AR agonists. C2 substitution probed geometrically through hA(2A)AR docking was important for binding in order of hexynyl > hexenyl > hexanyl. Compound 4g was the most potent ligand acting dually as hA(2A)AR agonist and hA(3)AR antagonist, which might be useful for treatment of asthma or other inflammatory diseases.

  20. Active Control of Inlet Noise on the JT15D Turbofan Engine

    NASA Technical Reports Server (NTRS)

    Smith, Jerome P.; Hutcheson, Florence V.; Burdisso, Ricardo A.; Fuller, Chris R.

    1999-01-01

    This report presents the key results obtained by the Vibration and Acoustics Laboratories at Virginia Tech over the year from November 1997 to December 1998 on the Active Noise Control of Turbofan Engines research project funded by NASA Langley Research Center. The concept of implementing active noise control techniques with fuselage-mounted error sensors is investigated both analytically and experimentally. The analytical part of the project involves the continued development of an advanced modeling technique to provide prediction and design guidelines for application of active noise control techniques to large, realistic high bypass engines of the type on which active control methods are expected to be applied. Results from the advanced analytical model are presented that show the effectiveness of the control strategies, and the analytical results presented for fuselage error sensors show good agreement with the experimentally observed results and provide additional insight into the control phenomena. Additional analytical results are presented for active noise control used in conjunction with a wavenumber sensing technique. The experimental work is carried out on a running JT15D turbofan jet engine in a test stand at Virginia Tech. The control strategy used in these tests was the feedforward Filtered-X LMS algorithm. The control inputs were supplied by single and multiple circumferential arrays of acoustic sources equipped with neodymium iron cobalt magnets mounted upstream of the fan. The reference signal was obtained from an inlet mounted eddy current probe. The error signals were obtained from a number of pressure transducers flush-mounted in a simulated fuselage section mounted in the engine test cell. The active control methods are investigated when implemented with the control sources embedded within the acoustically absorptive material on a passively-lined inlet. The experimental results show that the combination of active control techniques with fuselage

  1. 78 FR 75573 - Agency Information Collection Activities: Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-12

    ..., facsimile number (202) 646-3347, or email address [email protected] (HSEEP) After Action Report (AAR) Improvement Plan (IP). Type of Information Collection: Revision of a... Exercise and Evaluation Program (HSEEP) After Action Report (AAR) Improvement Plan (IP). Abstract: The...

  2. Paraveterinary service use in Nepal's Himalaya.

    PubMed

    Marshall, Edith S; Sischo, William M

    2010-06-01

    The involvement of paraveterinarians in animal-health delivery can reduce costs and allow expanded service delivery. Our objectives were to describe use of public paraveterinary services offered by junior technicians (JT) in two regions of Nepal, to identify factors associated with JT service use, and to characterize factors that limit JT service use. We used a survey of livestock owners in the Khumbu and Lower Mustang regions of Nepal's Himalaya to examine JT service use. Of 118 questionnaires completed between May 30, 1997 and July 8, 1997, 81 were analyzed for use of JT services to treat livestock: bovids, equids, and small ruminants. Five factors were associated with owners' use of JT services: living <30 min walk from a JT post (OR=12.2); having a positive opinion about JT services (OR=23.6); animals not having disease events that either impaired mobility or affected production or reproduction (OR=5.6), animals died related to a reported disease event (OR=3.2), and the owners' sex (with women being more likely to report use of JT services than men; OR=5.3). (c) 2010 Elsevier B.V. All rights reserved.

  3. Automatic anatomy recognition in post-tonsillectomy MR images of obese children with OSAS

    NASA Astrophysics Data System (ADS)

    Tong, Yubing; Udupa, Jayaram K.; Odhner, Dewey; Sin, Sanghun; Arens, Raanan

    2015-03-01

    Automatic Anatomy Recognition (AAR) is a recently developed approach for the automatic whole body wide organ segmentation. We previously tested that methodology on image cases with some pathology where the organs were not distorted significantly. In this paper, we present an advancement of AAR to handle organs which may have been modified or resected by surgical intervention. We focus on MRI of the neck in pediatric Obstructive Sleep Apnea Syndrome (OSAS). The proposed method consists of an AAR step followed by support vector machine techniques to detect the presence/absence of organs. The AAR step employs a hierarchical organization of the organs for model building. For each organ, a fuzzy model over a population is built. The model of the body region is then described in terms of the fuzzy models and a host of other descriptors which include parent to offspring relationship estimated over the population. Organs are recognized following the organ hierarchy by using an optimal threshold based search. The SVM step subsequently checks for evidence of the presence of organs. Experimental results show that AAR techniques can be combined with machine learning strategies within the AAR recognition framework for good performance in recognizing missing organs, in our case missing tonsils in post-tonsillectomy images as well as in simulating tonsillectomy images. The previous recognition performance is maintained achieving an organ localization accuracy of within 1 voxel when the organ is actually not removed. To our knowledge, no methods have been reported to date for handling significantly deformed or missing organs, especially in neck MRI.

  4. Alpha-1A Adrenergic receptor activation increases inhibitory tone in CA1 hippocampus

    PubMed Central

    Hillman, Kristin L.; Lei, Saobo; Doze, Van A.

    2009-01-01

    The endogenous catecholamine norepinephrine (NE) exhibits anti-epileptic properties, however it is not well understood which adrenergic receptor (AR) mediates this effect. The aim of this study was to investigate α1-adrenergic receptor (AR) activation in region CA1 of the hippocampus, a subcortical structure often implicated in temporal lobe epilepsies. Using cell-attached and whole-cell recordings in rat hippocampal slices, we confirmed that selective α1-AR activation increases action potential firing in a subpopulation of CA1 interneurons. We found that this response is mediated via the α1A-AR subtype, initiated by sodium influx, and appears independent of second messenger signaling. In CA1 pyramidal cells, α1A-AR activation decreases activity due to increased pre-synaptic GABA and somatostatin release. Examination of post-synaptic receptor involvement revealed that while GABAA receptors mediate the majority of α1A-adrenergic effects on CA1 pyramidal cells, significant contributions are also made by GABAB and somatostatin receptors. Finally, to test whether α1A-AR activation could have potential therapeutic implications, we performed AR agonist challenges using two in vitro epileptiform models. When GABAA receptors were available, α1A-AR activation significantly decreased epileptiform bursting in CA1. Together, our findings directly link stimulation of the α1A-AR subtype to release of GABA and somatostatin at the single cell level and suggest that α1A-AR activation may represent one mechanism by which NE exerts anti-epileptic effects within the hippocampus. PMID:19201164

  5. Alkali-aggregate reactivity of typical siliceious glass and carbonate rocks in alkali-activated fly ash based geopolymers

    NASA Astrophysics Data System (ADS)

    Lu, Duyou; Liu, Yongdao; Zheng, Yanzeng; Xu, Zhongzi; Shen, Xiaodong

    2013-08-01

    For exploring the behaviour of alkali-aggregate reactivity (AAR) in alkali-activated geopolymeric materials and assessing the procedures for testing AAR in geopolymers, the expansion behaviour of fly ash based geopolymer mortars with pure silica glass and typical carbonate rocks were studied respectively by curing at various conditions, i.e. 23°C and 38°C with relative humidity over 95%, immersed in 1M NaOH solution at 80°C. Results show that, at various curing conditions, neither harmful ASR nor harmful ACR was observed in geopolymers with the criteria specified for OPC system. However, with the change of curing conditions, the geopolymer binder and reactive aggregates may experience different reaction processes leading to quite different dimensional changes, especially with additional alkalis and elevated temperatures. It suggests that high temperature with additional alkali for accelerating AAR in traditional OPC system may not appropriate for assessing the alkali-aggregate reactivity behaviour in geopolymers designed for normal conditions. On the other hand, it is hopeful to control the dimensional change of geopolymer mortar or concrete by selecting the type of aggregates and the appropriate curing conditions, thus changing the harmful AAR in OPC into beneficial AAR in geopolymers and other alkali-activated cementitious systems.

  6. Optical designs of reflection and refraction collection optics for a JT-60SA core Thomson scattering system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tojo, H.; Hatae, T.; Hamano, T.

    2013-09-15

    Collection optics for core measurements in a JT-60SA Thomson scattering system were designed. The collection optics will be installed in a limited space and have a wide field of view and wide wavelength range. Two types of the optics are therefore suggested: refraction and reflection types. The reflection system, with a large primary mirror, avoids large chromatic aberrations. Because the size limit of the primary mirror and vignetting due to the secondary mirror affect the total collection throughput, conditions that provide the high throughput are found through an optimization. A refraction system with four lenses forming an Ernostar system ismore » also employed. The use of high-refractive-index glass materials enhances the freedom of the lens curvatures, resulting in suppression of the spherical and coma aberration. Moreover, sufficient throughput can be achieved, even with smaller lenses than that of a previous design given in [H. Tojo, T. Hatae, T. Sakuma, T. Hamano, K. Itami, Y. Aida, S. Suitoh, and D. Fujie, Rev. Sci. Instrum. 81, 10D539 (2010)]. The optical resolutions of the reflection and refraction systems are both sufficient for understanding the spatial structures in plasma. In particular, the spot sizes at the image of the optics are evaluated as ∼0.3 mm and ∼0.4 mm, respectively. The throughput for the two systems, including the pupil size and transmissivity, are also compared. The results show that good measurement accuracy (<10%) even at high electron temperatures (<30 keV) can be expected in the refraction system.« less

  7. Optical designs of reflection and refraction collection optics for a JT-60SA core Thomson scattering system.

    PubMed

    Tojo, H; Hatae, T; Hamano, T; Sakuma, T; Itami, K

    2013-09-01

    Collection optics for core measurements in a JT-60SA Thomson scattering system were designed. The collection optics will be installed in a limited space and have a wide field of view and wide wavelength range. Two types of the optics are therefore suggested: refraction and reflection types. The reflection system, with a large primary mirror, avoids large chromatic aberrations. Because the size limit of the primary mirror and vignetting due to the secondary mirror affect the total collection throughput, conditions that provide the high throughput are found through an optimization. A refraction system with four lenses forming an Ernostar system is also employed. The use of high-refractive-index glass materials enhances the freedom of the lens curvatures, resulting in suppression of the spherical and coma aberration. Moreover, sufficient throughput can be achieved, even with smaller lenses than that of a previous design given in [H. Tojo, T. Hatae, T. Sakuma, T. Hamano, K. Itami, Y. Aida, S. Suitoh, and D. Fujie, Rev. Sci. Instrum. 81, 10D539 (2010)]. The optical resolutions of the reflection and refraction systems are both sufficient for understanding the spatial structures in plasma. In particular, the spot sizes at the image of the optics are evaluated as ~0.3 mm and ~0.4 mm, respectively. The throughput for the two systems, including the pupil size and transmissivity, are also compared. The results show that good measurement accuracy (<10%) even at high electron temperatures (<30 keV) can be expected in the refraction system.

  8. Jumping translocations in hematological malignancies: a cytogenetic study of five cases.

    PubMed

    Manola, Kalliopi N; Georgakakos, Vasileios N; Stavropoulou, Chryssa; Spyridonidis, Alexandros; Angelopoulou, Maria K; Vlachadami, Ioanna; Katsigiannis, Andreas; Roussou, Paraskevi; Pantelias, Gabriel E; Sambani, Constantina

    2008-12-01

    Jumping translocations (JT) are rare cytogenetic aberrations in hematological malignancies that include unbalanced translocations involving a donor chromosome arm or chromosome segment that has fused to two or more different recipient chromosomes in different cell lines. We report five cases associated with different hematologic disorders and JT to contribute to the investigation of the origin, pathogenesis, and clinical significance of JT. These cases involve JT of 1q in a case of acute myeloblastic leukemia (AML)-M1, a case of Burkitt lymphoma, and a case of BCR/ABL-positive acute lymphoblastic leukemia, as well as a JT of 13q in a case of AML-M5, and a JT of 11q segment in a case of undifferentiated leukemia. To our knowledge, with regard to hematologic malignancies, this study presents the first case of JT associated with AML-M1, the first case of JT involving 13q as a donor chromosome, and the first report of JT involving a segment of 11q containing two copies of the MLL gene, jumping on to two recipient chromosomes in each cell line and resulting in six copies of the MLL gene. Our investigation suggests that JT may not contribute to the pathogenesis but rather to the progression of the disease, and it demonstrates that chromosome band 1q10 as a breakpoint of the donor chromosome 1q is also implicated in AML, not only in multiple myeloma as it has been known until now.

  9. 78 FR 48765 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-09

    ... safety appliance arrangements on modern railcar types not explicitly covered by 49 CFR Part 231. The Task... all car types, plus industry safety appliance standards for specific car types. These industry... arrangements for individual car types. AAR also included deviation tables that show where the AAR standard...

  10. 78 FR 10263 - Proposed Collection; Comment Request for Form 8082

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-13

    ..., Public Law 104-13 (44 U.S.C. 3506(c)(2)(A)). Currently, the IRS is soliciting comments concerning Form 8082, Notice of Inconsistent Treatment or Administrative Adjustment Request (AAR). DATES: Written... Inconsistent Treatment or Administrative Adjustment Request (AAR). OMB Number: 1545-0790. Form Number: 8082...

  11. 78 FR 60301 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-01

    ... Evaluation Program (HSEEP) After Action Report (AAR) Improvement Plan (IP). DATES: Comments must be submitted...) Improvement Plan (IP) provides a standardized method for reporting the results of preparedness exercises and identifying, correcting and sharing as appropriate strengths and areas for improvement. Thus, the HSEEP AAR/IP...

  12. Using Rapid Improvement Events for Disaster After-Action Reviews: Experience in a Hospital Information Technology Outage and Response.

    PubMed

    Little, Charles M; McStay, Christopher; Oeth, Justin; Koehler, April; Bookman, Kelly

    2018-02-01

    The use of after-action reviews (AARs) following major emergency events, such as a disaster, is common and mandated for hospitals and similar organizations. There is a recurrent challenge of identified problems not being resolved and repeated in subsequent events. A process improvement technique called a rapid improvement event (RIE) was used to conduct an AAR following a complete information technology (IT) outage at a large urban hospital. Using RIE methodology to conduct the AAR allowed for the rapid development and implementation of major process improvements to prepare for future IT downtime events. Thus, process improvement methodology, particularly the RIE, is suited for conducting AARs following disasters and holds promise for improving outcomes in emergency management. Little CM , McStay C , Oeth J , Koehler A , Bookman K . Using rapid improvement events for disaster after-action reviews: experience in a hospital information technology outage and response. Prehosp Disaster Med. 2018;33(1):98-100.

  13. Fast plasma shutdown by killer pellet injection in JT-60U with reduced heat flux on the divertor plate and avoiding runaway electron generation

    NASA Astrophysics Data System (ADS)

    Yoshino, R.; Kondoh, T.; Neyatani, Y.; Itami, K.; Kawano, Y.; Isei, N.

    1997-02-01

    A killer pellet is an impurity pellet that is injected into a tokamak plasma in order to terminate a discharge without causing serious damage to the tokamak machine. In JT-60U neon ice pellets have been injected into OH and NB heated plasmas and fast plasma shutdowns have been demonstrated without large vertical displacement. The heat pulse on the divertor plate has been greatly reduced by killer pellet injection (KPI), but a low-power heat flux tail with a long time duration is observed. The total energy on the divertor plate increases with longer heat flux tail, so it has been reduced by shortening the tail. Runaway electron (RE) generation has been observed just after KPI and/or in the later phase of the plasma current quench. However, RE generation has been avoided when large magnetic perturbations are excited. These experimental results clearly show that KPI is a credible fast shutdown method avoiding large vertical displacement, reducing heat flux on the divertor plate, and avoiding (or minimizing) RE generation.

  14. Selective regulation of nuclear orphan receptors 4A by adenosine receptor subtypes in human mast cells

    PubMed Central

    Zhang, Li; Paine, Catherine

    2010-01-01

    Nuclear orphan receptors 4A (NR4A) are early responsive genes that belong to the superfamily of hormone receptors and comprise NR4A1, NR4A2 and NR4A3. They have been associated to transcriptional activation of multiple genes involved in inflammation, apoptosis and cell cycle control. Here, we establish a link between NR4As and adenosine, a paradoxical inflammatory molecule that can contribute to persistence of inflammation or mediate inflammatory shutdown. Transcriptomics screening of the human mast cell-line HMC-1 revealed a sharp induction of transcriptionally active NR4A2 and NR4A3 by the adenosine analogue NECA. The concomitant treatment of NECA and the adenosine receptor A2A (A2AAR) selective antagonist SCH-58261 exaggerated this effect, suggesting that upregulation of these factors in mast cells is mediated by other AR subtypes (A2B and A3) and that A2AAR activation counteracts NR4A2 and NR4A3 induction. In agreement with this, A2AAR-silencing amplified NR4A induction by NECA. Interestingly, a similar A2AAR modulatory effect was observed on ERK1/2 phosphorylation because A2AAR blockage exacerbated NECA-mediated phosphorylation of ERK1/2. In addition, PKC or MEK1/2 inhibition prevented ERK1/2 phosphorylation and antagonized AR-mediated induction of NR4A2 and NR4A3, suggesting the involvement of these kinases in AR to NR4A signaling. Finally, we observed that selective A2AAR activation with CGS-21680 blocked PMA-induced ERK1/2 phosphorylation and modulated the overexpression of functional nuclear orphan receptors 4A. Taken together, these results establish a novel PKC/ERK/nuclear orphan receptors 4A axis for adenosinergic signaling in mast cells, which can be modulated by A2AAR activation, not only in the context of adenosine but of other mast cell activating stimuli as well. PMID:21234122

  15. Multi-Inhibitory Effects of A2A Adenosine Receptor Signaling on Neutrophil Adhesion Under Flow.

    PubMed

    Yago, Tadayuki; Tsukamoto, Hiroki; Liu, Zhenghui; Wang, Ying; Thompson, Linda F; McEver, Rodger P

    2015-10-15

    A2A adenosine receptor (A2AAR) signaling negatively regulates inflammatory responses in many disease models, but the detailed mechanisms remain unclear. We used the selective A2AAR agonist, ATL313, to examine how A2AAR signaling affects human and murine neutrophil adhesion under flow. Treating neutrophils with ATL313 inhibited selectin-induced, β2 integrin-dependent slow rolling and chemokine-induced, β2 integrin-dependent arrest on ICAM-1. ATL313 inhibited selectin-induced β2 integrin extension, which supports slow rolling, and chemokine-induced hybrid domain "swing-out," which supports arrest. Furthermore, ATL313 inhibited integrin outside-in signaling as revealed by reduced neutrophil superoxide production and spreading on immobilized anti-β2 integrin Ab. ATL313 suppressed selectin-triggered activation of Src family kinases (SFKs) and p38 MAPK, chemokine-triggered activation of Ras-related protein 1, and β2 integrin-triggered activation of SFKs and Vav cytoskeletal regulatory proteins. ATL313 activated protein kinase A and its substrate C-terminal Src kinase, an inhibitor of SFKs. Treating neutrophils with a protein kinase A inhibitor blocked the actions of ATL313. In vivo, ATL313-treated neutrophils rolled faster and arrested much less frequently in postcapillary venules of the murine cremaster muscle after TNF-α challenge. Furthermore, ATL313 markedly suppressed neutrophil migration into the peritoneum challenged with thioglycollate. ATL313 did not affect A2AAR-deficient neutrophils, confirming its specificity. Our findings provide new insights into the anti-inflammatory mechanisms of A2AAR signaling and the potential utility of A2AAR agonists in inflammatory diseases. Copyright © 2015 by The American Association of Immunologists, Inc.

  16. Multi-inhibitory effects of A2A adenosine receptor signaling on neutrophil adhesion under flow**

    PubMed Central

    Yago, Tadayuki; Tsukamoto, Hiroki; Liu, Zhenghui; Wang, Ying; Thompson, Linda F.; McEver, Rodger P.

    2015-01-01

    A2A adenosine receptor (A2AAR) signaling negatively regulates inflammatory responses in many disease models, but the detailed mechanisms remain unclear. We used the selective A2AAR agonist, ATL313, to examine how A2AAR signaling affects human and murine neutrophil adhesion under flow. Treating neutrophils with ATL313 inhibited selectin-induced, β2 integrin-dependent slow rolling and chemokine-induced, β2 integrin-dependent arrest on ICAM-1. ATL313 inhibited selectin-induced β2 integrin extension, which supports slow rolling, and chemokine-induced hybrid domain “swing-out”, which supports arrest. Furthermore, ATL313 inhibited integrin outside-in signaling as revealed by reduced neutrophil superoxide production and spreading on immobilized anti-β2 integrin antibody. ATL313 suppressed selectin-triggered activation of Src family kinases (SFKs) and p38 MAPK, chemokine-triggered activation of Ras-related protein 1 (Rap1), and β2 integrin-triggered activation of SFKs and Vav cytoskeletal regulatory proteins. ATL313 activated protein kinase A (PKA) and its substrate C-terminal Src kinase (Csk), an inhibitor of SFKs. Treating neutrophils with a PKA inhibitor blocked the actions of ATL313. In vivo, ATL313-treated neutrophils rolled faster and arrested much less frequently in postcapillary venules of the murine cremaster muscle after TNF-α challenge. Furthermore, ATL313 markedly suppressed neutrophil migration into the peritoneum challenged with thioglycollate. ATL313 did not affect A2AAR-deficient neutrophils, confirming its specificity. Our findings provide new insights into the anti-inflammatory mechanisms of A2AAR signaling and the potential utility of A2AAR agonists in inflammatory diseases. PMID:26355151

  17. Ab initio study of dynamical E × e Jahn-Teller and spin-orbit coupling effects in the transition-metal trifluorides TiF3, CrF3, and NiF3

    NASA Astrophysics Data System (ADS)

    Mondal, Padmabati; Opalka, Daniel; Poluyanov, Leonid V.; Domcke, Wolfgang

    2012-02-01

    Multiconfiguration ab initio methods have been employed to study the effects of Jahn-Teller (JT) and spin-orbit (SO) coupling in the transition-metal trifluorides TiF3, CrF3, and NiF3, which possess spatially doubly degenerate excited states (ME) of even spin multiplicities (M = 2 or 4). The ground states of TiF3, CrF3, and NiF3 are nondegenerate and exhibit minima of D3h symmetry. Potential-energy surfaces of spatially degenerate excited states have been calculated using the state-averaged complete-active-space self-consistent-field method. SO coupling is described by the matrix elements of the Breit-Pauli operator. Linear and higher order JT coupling constants for the JT-active bending and stretching modes as well as SO-coupling constants have been determined. Vibronic spectra of JT-active excited electronic states have been calculated, using JT Hamiltonians for trigonal systems with inclusion of SO coupling. The effect of higher order (up to sixth order) JT couplings on the vibronic spectra has been investigated for selected electronic states and vibrational modes with particularly strong JT couplings. While the weak SO couplings in TiF3 and CrF3 are almost completely quenched by the strong JT couplings, the stronger SO coupling in NiF3 is only partially quenched by JT coupling.

  18. A four-way junction with triple-helical arms: design, characterization, and stability.

    PubMed

    Makube, N; Klump, H H

    2000-05-01

    The formation of the four-way junction containing four triple-helical arms has been demonstrated using chemical methods (polyacrylamide gel electrophoresis and chemical footprinting using OsO(4) as a probe) and physical methods (UV absorbance melting and DSC). The junction J(T1T3) was assembled from two 20-mer purine strands and two 44-mer pyrimidine strands. To determine the contribution of the different arms to the stability of the complete structure of J(T1T3), the junction was compared to two simplified substructures, J(T1) and J(T3), respectively. Common to these complexes is the underlying double-helical four-way junction Js. Addition of Na(+) had a profound effect on stabilizing and subsequently folding the junctions into the stacked X-structures. The following results support the structure present: (i) The native polyacrylamide electrophoresis exhibits only a single band(s) corresponding to one species present when all four single strands are mixed in equal amounts. (ii) OsO(4) modifications were investigated at pH 5.0 and in the presence of 10 mM Mg(2+) and 100 mM Na(+). There is no cleavage of thymine residues at the branch point and throughout the structure. (iii) The thermal unfolding of J(T1) and J(T3) illustrates that the triple-helical arms are more stable than the double-helical arms which are contained in these junctions and that J(T1T3) with four triple-helical arms is slightly more stable than J(T1) and J(T3). (iv) The calorimetric transition enthalpies determined for the arms of J(T1T3) are comparable to those associated with the unfolding of its corresponding arms in J(T1) and J(T3). The results also illustrate that the formation of the junctions is not restricted by the pH, [Na(+)], sequence composition of the arms, and/or the loop position. Copyright 2000 Academic Press.

  19. Azacitidine for Front-Line Therapy of Patients with AML: Reproducible Efficacy Established by Direct Comparison of International Phase 3 Trial Data with Registry Data from the Austrian Azacitidine Registry of the AGMT Study Group

    PubMed Central

    Pleyer, Lisa; Döhner, Hartmut; Dombret, Hervé; Seymour, John F.; Schuh, Andre C.; Beach, CL; Swern, Arlene S.; Burgstaller, Sonja; Stauder, Reinhard; Girschikofsky, Michael; Sill, Heinz; Schlick, Konstantin; Thaler, Josef; Halter, Britta; Machherndl Spandl, Sigrid; Zebisch, Armin; Pichler, Angelika; Pfeilstöcker, Michael; Autzinger, Eva M.; Lang, Alois; Geissler, Klaus; Voskova, Daniela; Sperr, Wolfgang R.; Hojas, Sabine; Rogulj, Inga M.; Andel, Johannes; Greil, Richard

    2017-01-01

    We recently published a clinically-meaningful improvement in median overall survival (OS) for patients with acute myeloid leukaemia (AML), >30% bone marrow (BM) blasts and white blood cell (WBC) count ≤15 G/L, treated with front-line azacitidine versus conventional care regimens within a phase 3 clinical trial (AZA-AML-001; NCT01074047; registered: February 2010). As results obtained in clinical trials are facing increased pressure to be confirmed by real-world data, we aimed to test whether data obtained in the AZA-AML-001 trial accurately represent observations made in routine clinical practice by analysing additional AML patients treated with azacitidine front-line within the Austrian Azacitidine Registry (AAR; NCT01595295; registered: May 2012) and directly comparing patient-level data of both cohorts. We assessed the efficacy of front-line azacitidine in a total of 407 patients with newly-diagnosed AML. Firstly, we compared data from AML patients with WBC ≤ 15 G/L and >30% BM blasts included within the AZA-AML-001 trial treated with azacitidine (“AML-001” cohort; n = 214) with AAR patients meeting the same inclusion criteria (“AAR (001-like)” cohort; n = 95). The current analysis thus represents a new sub-analysis of the AML-001 trial, which is directly compared with a new sub-analysis of the AAR. Baseline characteristics, azacitidine application, response rates and OS were comparable between all patient cohorts within the trial or registry setting. Median OS was 9.9 versus 10.8 months (p = 0.616) for “AML-001” versus “AAR (001-like)” cohorts, respectively. Secondly, we pooled data from both cohorts (n = 309) and assessed the outcome. Median OS of the pooled cohorts was 10.3 (95% confidence interval: 8.7, 12.6) months, and the one-year survival rate was 45.8%. Thirdly, we compared data from AAR patients meeting AZA-AML-001 trial inclusion criteria (n = 95) versus all AAR patients with World Health Organization (WHO)-defined AML (“AAR (WHO

  20. Defining Educational Research: A Perspective of/on Presidential Addresses and the Australian Association for Research in Education

    ERIC Educational Resources Information Center

    Lingard, Bob; Gale, Trevor

    2010-01-01

    This paper is concerned with the definition of the field of educational research and the changing and developing role of the Australian Association for Research in Education (AARE) in representing and constituting this field. The evidence for the argument is derived from AARE Presidential Addresses across its 40-year history. The paper documents…

  1. 76 FR 55819 - Track Safety Standards; Concrete Crossties

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-09

    ... geometry car that had operated over BNSF's Seadrift subdivision on December 14, 2010. According to AAR... is surprised that AAR asserts at this stage in the rulemaking process that the technology to perform... accuracy specified by Sec. 213.234, or \\1/8\\ of an inch, without mandating which technology should be used...

  2. Excellent amino acid racemization results from Holocene sand dollars

    NASA Astrophysics Data System (ADS)

    Kosnik, M.; Kaufman, D. S.; Kowalewski, M.; Whitacre, K.

    2015-12-01

    Amino acid racemization (AAR) is widely used as a cost-effective method to date molluscs in time-averaging and taphonomic studies, but it has not been attempted for echinoderms despite their paleobiological importance. Here we demonstrate the feasibility of AAR geochronology in Holocene aged Peronella peronii (Echinodermata: Echinoidea) collected from Sydney Harbour (Australia). Using standard HPLC methods we determined the extent of AAR in 74 Peronella tests and performed replicate analyses on 18 tests. We sampled multiple areas of two individuals and identified the outer edge as a good sampling location. Multiple replicate analyses from the outer edge of 18 tests spanning the observed range of D/Ls yielded median coefficients of variation < 4% for Asp, Phe, Ala, and Glu D/L values, which overlaps with the analytical precision. Correlations between D/L values across 155 HPLC injections sampled from 74 individuals are also very high (pearson r2 > 0.95) for these four amino acids. The ages of 11 individuals spanning the observed range of D/L values were determined using 14C analyses, and Bayesian model averaging was used to determine the best AAR age model. The averaged age model was mainly composed of time-dependent reaction kinetics models (TDK, 71%) based on phenylalanine (Phe, 94%). Modelled ages ranged from 14 to 5539 yrs, and the median 95% confidence interval for the 74 analysed individuals is ±28% of the modelled age. In comparison, the median 95% confidence interval for the 11 calibrated 14C ages was ±9% of the median age estimate. Overall Peronella yields exceptionally high-quality AAR D/L values and appears to be an excellent substrate for AAR geochronology. This work opens the way for time-averaging and taphonomic studies of echinoderms similar to those in molluscs.

  3. Smoking cessation treatment practices: recommendations for improved adoption on cardiology wards.

    PubMed

    Berndt, Nadine C; Bolman, Catherine; de Vries, Hein; Segaar, Dewi; van Boven, Irene; Lechner, Lilian

    2013-01-01

    Smoking cessation treatment practices described by the 5 A's (ask, advise, assess, assist, arrange) are not well applied at cardiology wards because of various reasons, such as a lack of time and appropriate skills of the nursing staff. Therefore, a simplified guideline proposing an ask-advise-refer (AAR) strategy was introduced in Dutch cardiac wards. This study aimed to identify factors that determine the intentions of cardiac ward heads in adopting the simplified AAR guideline, as ward heads are key decision makers in the adoption of new guidelines. Ward heads' perceptions of current smoking cessation practices at the cardiac ward were also investigated. A cross-sectional survey with written questionnaires was conducted among heads of cardiology wards throughout the Netherlands, of whom 117 (64%) responded. According to the heads of cardiac wards, smoking cessation practices by cardiologists and nurses were mostly limited to brief practices that are easy to conduct. Only a minority offered intensive counseling or arranged follow-up contact. Heads with strong intentions of adopting the AAR guideline differed significantly on motivational and organizational attributes and perceived more smoking cessation assistance by other health professionals than did heads with weak intentions of adopting. Positive attitudes, social support toward adoption, and perception of much assistance at the ward were significantly associated with increased intentions to adopt the AAR guideline. Brief smoking cessation practices are adequately performed at cardiac wards, but the most effective practices, offering assistance and arranging for follow-up, are less than optimal. The AAR guideline offers a more feasible approach for busy cardiology wards. To ensure successful adoption of this guideline, the heads of cardiac wards should be convinced of its advantages and be encouraged by a supportive work environment. Policies may also facilitate the adoption of the AAR guideline.

  4. An analysis of root cause identification and continuous quality improvement in public health H1N1 after-action reports.

    PubMed

    Singleton, Christa-Marie; Debastiani, Summer; Rose, Dale; Kahn, Emily B

    2014-01-01

    To identify the extent to which the Homeland Security Exercise and Evaluation Program's (HSEEP) After Action Report/Improvement Plan (AAR/IP) template was followed by public health entities and facilitated the identification of detailed corrective actions and continuous improvement. Data were drawn from the US H1N1 Public Health Emergency Response (PHER) federal grant awardees (n = 62). After action report/improvement plan text was examined to identify the presence of AAR/IP HSEEP elements and characterized as "minimally complete," "partially complete," or "complete." Corrective actions (CA) and recommendations within the IP focusing on performance deficits were coded as specific, measurable, and time-bound, and whether they were associated with a problem that met root cause criteria and whether the CA/recommendation was intended to address or fix the root cause. A total of 2619 CA/recommendations were identified. More than half (n = 1480, 57%) addressed root causes. Corrective actions/recommendations associated with complete AARs more frequently addressed root cause (58% vs 51%, χ = 9.1, P < 0.003) and were more specific (34% vs 23%, χ = 32.3, P < 0.0001), measurable (30% vs 18%, χ = 37.9, P < 0.0001), and time-bound (38% vs 15%, χ = 115.5, P < 0.0001) than partially complete AARs. The same pattern was not observed with completeness of IPs. Corrective actions and recommendations were similarly specific and measurable. Recommendations significantly addressed root cause more than CAs. Our analysis indicates a possible lack of awardee distinction between CA and recommendations in AARs. As HSEEP adapts to align with the 2011 National Preparedness Goal and National Preparedness System, future HSEEP documents should emphasize the importance of root cause analysis as a required element within AAR documents and templates in the exercise and real incident environment, as well as the need for specific and measurable CAs.

  5. Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification

    PubMed Central

    Fang, Pengfei; Guo, Min

    2015-01-01

    Aminoacyl-tRNA synthetases (aaRSs) are enzymes that catalyze the transfer of amino acids to their cognate tRNAs as building blocks for translation. Each of the aaRS families plays a pivotal role in protein biosynthesis and is indispensable for cell growth and survival. In addition, aaRSs in higher species have evolved important non-translational functions. These translational and non-translational functions of aaRS are attractive for developing antibacterial, antifungal, and antiparasitic agents and for treating other human diseases. The interplay between amino acids, tRNA, ATP, EF-Tu and non-canonical binding partners, had shaped each family with distinct pattern of key sites for regulation, with characters varying among species across the path of evolution. These sporadic variations in the aaRSs offer great opportunity to target these essential enzymes for therapy. Up to this day, growing numbers of aaRS inhibitors have been discovered and developed. Here, we summarize the latest developments and structural studies of aaRS inhibitors, and classify them with distinct binding modes into five categories. PMID:26670257

  6. Aminoacyl-tRNA synthetases database Y2K

    PubMed Central

    Szymanski, Maciej; Barciszewski, Jan

    2000-01-01

    The aminoacyl-tRNA synthetases (AARS) are a diverse group of enzymes that ensure the fidelity of transfer of genetic information from DNA into protein. They catalyse the attachment of amino acids to transfer RNAs and thereby establish the rules of the genetic code by virtue of matching the nucleotide triplet of the anticodon with its cognate amino acid. Currently, 818 AARS primary structures have been reported from archaebacteria, eubacteria, mitochondria, chloroplasts and eukaryotic cells. The database is a compilation of the amino acid sequences of all AARSs, known to date, which are available as separate entries or alignments of related proteins via the WWW at http://rose.man.poznan.pl/aars/index.html PMID:10592262

  7. Aminoacyl-tRNA synthetases database Y2K.

    PubMed

    Szymanski, M; Barciszewski, J

    2000-01-01

    The aminoacyl-tRNA synthetases (AARS) are a diverse group of enzymes that ensure the fidelity of transfer of genetic information from DNA into protein. They catalyse the attachment of amino acids to transfer RNAs and thereby establish the rules of the genetic code by virtue of matching the nucleotide triplet of the anticodon with its cognate amino acid. Currently, 818 AARS primary structures have been reported from archaebacteria, eubacteria, mitochondria, chloro-plasts and eukaryotic cells. The database is a compilation of the amino acid sequences of all AARSs, known to date, which are available as separate entries or alignments of related proteins via the WWW at http://rose.man.poznan.pl/aars/index.html

  8. The results of a low speed wind tunnel test to investigate the effects of installing refan JT8D engines on the McDonnell Douglas DC-9-30

    NASA Technical Reports Server (NTRS)

    Chrisenberry, H. E.; Doss, P. G.; Kressly, A. E.; Prichard, R. D.; Thorndike, C. S.

    1973-01-01

    A low speed wind tunnel test was conducted to assess the effects of the larger JT8D refan nacelles on the stability and control characteristics of the DC-9-30, with emphasis on the deep stall regime. Deep stall pitching moment and elevator hinge moment data, and low angle of attack tail-on and tail-off pitching moment data are presented. The refan nacelle was tested in conjunction with various pylons of reduced span relative to the production DC-9-30 pylon. Also, a horizontal tail that was larger than the production tail was tested. The data show that the refan installation has a small detrimental effect on the DC-9-30 deep stall recovery capability, that recovery characteristics are essentially independent of pylon span, and that the larger horizontal tail significantly increases recovery margins. The deep stall characteristics with the refan installation, within the range of pylon spans tested, are acceptable with no additional design changes anticipated.

  9. 2014 Australian Association for Research in Education Presidential Address: Educational Research and the Tree of Knowledge in a Post Human Digital Age

    ERIC Educational Resources Information Center

    Moss, Julianne

    2016-01-01

    The 2014, 41st Australian Association for Research in Education (AARE) presidential address is both inspired and guided by the discursive genres of presidential addresses and the role of the president in a member association such as AARE. In the address, typically the president speaks to the members on an issue or issues that are to shape or…

  10. After-Action Reviews - who conducts them?

    Treesearch

    Anne E. Black; Kathleen Sutcliffe; Michelle Barton

    2009-01-01

    Reflecting on the links between intentions and outcomes is a key practice of a learning organization (Garvin 2000). The After-Action Review (AAR) is a formal reflection process intended to assist groups in capturing lessons learned from a task. AARs typically ask four questions regarding fire-response operations: (1) what did we set out to do, (2) what actually...

  11. Jahn-Teller effect in molecular electronics: quantum cellular automata

    NASA Astrophysics Data System (ADS)

    Tsukerblat, B.; Palii, A.; Clemente-Juan, J. M.; Coronado, E.

    2017-05-01

    The article summarizes the main results of application of the theory of the Jahn-Teller (JT) and pseudo JT effects to the description of molecular quantum dot cellular automata (QCA), a new paradigm of quantum computing. The following issues are discussed: 1) QCA as a new paradigm of quantum computing, principles and advantages; 2) molecular implementation of QCA; 3) role of the JT effect in charge trapping, encoding of binary information in the quantum cell and non-linear cell-cell response; 4) spin-switching in molecular QCA based on mixed-valence cell; 5) intervalence optical absorption in tetrameric molecular mixed-valence cell through the symmetry assisted approach to the multimode/multilevel JT and pseudo JT problems.

  12. Bifunctional staining for ex vivo determination of area at risk in rabbits with reperfused myocardial infarction

    PubMed Central

    Feng, Yuanbo; Ma, Zhan-Long; Chen, Feng; Yu, Jie; Cona, Marlein Miranda; Xie, Yi; Li, Yue; Ni, Yicheng

    2013-01-01

    AIM: To develop a method for studying myocardial area at risk (AAR) in ischemic heart disease in correlation with cardiac magnetic resonance imaging (cMRI). METHODS: Nine rabbits were anesthetized, intubated and subjected to occlusion and reperfusion of the left circumflex coronary artery (LCx) to induce myocardial infarction (MI). ECG-triggered cMRI with delayed enhancement was performed at 3.0 T. After euthanasia, the heart was excised with the LCx re-ligated. Bifunctional staining was performed by perfusing the aorta with a homemade red-iodized-oil (RIO) dye. The heart was then agar-embedded for ex vivo magnetic resonance imaging and sliced into 3 mm-sections. The AAR was defined by RIO-staining and digital radiography (DR). The perfusion density rate (PDR) was derived from DR for the AAR and normal myocardium. The MI was measured by in vivo delayed enhancement (iDE) and ex vivo delayed enhancement (eDE) cMRI. The AAR and MI were compared to validate the bifunctional straining for cardiac imaging research. Linear regression with Bland-Altman agreement, one way-ANOVA with Bonferroni’s multiple comparison, and paired t tests were applied for statistics. RESULTS: All rabbits tolerated well the surgical procedure and subsequent cMRI sessions. The open-chest occlusion and close-chest reperfusion of the LCx, double suture method and bifunctional staining were successfully applied in all animals. The percentage MI volumes globally (n = 6) and by slice (n = 25) were 36.59% ± 13.68% and 32.88% ± 12.38% on iDE, and 35.41% ± 12.25% and 32.40% ± 12.34% on eDE. There were no significant differences for MI determination with excellent linear regression correspondence (rglobal = 0.89; rslice = 0.9) between iDE and eDE. The percentage AAR volumes globally (n = 6) and by slice (n = 25) were 44.82% ± 15.18% and 40.04% ± 13.64% with RIO-staining, and 44.74% ± 15.98% and 40.48% ± 13.26% by DR showing high correlation in linear regression analysis (rglobal = 0.99; rslice

  13. Current Practice and Theoretical Foundations of the After Action Review

    DTIC Science & Technology

    2011-06-01

    Stephen L. Goldberg , Chief U.S. Army Research Institute for the Behavioral and Social Sciences 2511 Jefferson Davis Highway, Arlington, Virginia...were many occasions where 37 the facilitators’ knowledge of the battle tempo , dynamics, and resources added to the SA of team members. Such...attending AARs. There appear to be frequent variations in organizational status among participants in traditional industry AARs. In military

  14. The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatment.

    PubMed

    Saint-Léger, Adélaïde; Sinadinos, Christopher; Ribas de Pouplana, Lluís

    2016-04-02

    Malaria remains a major global health problem. Parasite resistance to existing drugs makes development of new antimalarials an urgency. The protein synthesis machinery is an excellent target for the development of new anti-infectives, and aminoacyl-tRNA synthetases (aaRS) have been validated as antimalarial drug targets. However, avoiding the emergence of drug resistance and improving selectivity to target aaRS in apicomplexan parasites, such as Plasmodium falciparum, remain crucial challenges. Here we discuss such issues using examples of known inhibitors of P. falciparum aaRS, namely halofuginone, cladosporin and borrelidin (inhibitors of ProRS, LysRS and ThrRS, respectively). Encouraging recent results provide useful guidelines to facilitate the development of novel drug candidates which are more potent and selective against these essential enzymes.

  15. Construction of new cloning, lacZ reporter and scarless-markerless suicide vectors for genetic studies in Aggregatibacter actinomycetemcomitans

    PubMed Central

    Juárez-Rodríguez, María Dolores; Torres-Escobar, Ascención; Demuth, Donald R.

    2013-01-01

    To elucidate the putative function of a gene, effective tools are required for genetic characterization that facilitate its inactivation, deletion or modification on the bacterial chromosome. In the present study, the nucleotide sequence of the Escherichia coli/Aggregatibacter actinomycetemcomitans shuttle vector pYGK was determined, allowing us to redesign and construct a new shuttle cloning vector, pJT4, and promoterless lacZ transcriptional/translational fusion plasmids, pJT3 and pJT5. Plasmids pJT4 and pJT5 contain the origin of replication necessary to maintain shuttle vector replication. In addition, a new suicide vector, pJT1, was constructed for the generation of scarless and markerless deletion mutations of genes in the oral pathogen A. actinomycetemcomitans. Plasmid pJT1 is a pUC-based suicide vector that is counter-selectable for sucrose sensitivity. This vector does not leave antibiotic markers or scars on the chromosome after gene deletion and thus provides the option to combine several mutations in the same genetic background. The effectiveness of pJT1 was demonstrated by the construction of A. actinomycetemcomitans isogenic qseB single deletion (ΔqseB) mutant and lsrRK double deletion mutants (ΔlsrRK). These new vectors may offer alternatives for genetic studies in A. actinomycetemcomitans and other members of the HACEK (Haemophilus spp., A. actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae) group of Gram-negative bacteria. PMID:23353051

  16. New Surgical Drapes for Observation of the Lower Extremities during Abdominal Aortic Repair.

    PubMed

    Obitsu, Yukio; Shigematsu, Hiroshi; Satou, Kazuhiro; Watanabe, Yoshiko; Saiki, Naozumi; Koizumii, Nobusato

    2010-01-01

    For the early diagnosis and therapy of peripheral thromboembolism (TE) as a complication of abdominal aortic repair (AAR), we developed and evaluated the usefulness of surgical drapes that permit observation of the lower extremities during AAR. Between January 2007 and June 2009, the handling, durability, and usefulness of new surgical drapes were evaluated during AAR in 157 patients with abdominal aortic aneurysms and 9 patients with peripheral arterial disease. The drapes are manufactured by Hogy Medical Co. Ltd. and made of a water-repellent, spun lace, non-woven fabric, including a transparent polyethylene film that covers the patients' legs. This transparent film enables inspection and palpation of the lower extremities during surgery for early diagnosis and therapy of peripheral TE. As a peripheral complication, 1 patient had right lower extremity TE. This was diagnosed immediately after anastomosis, thrombectomy was performed, and the remaining clinical course was uneventful. In all patients, the drapes permitted observation of the lower extremities , and the dorsal arteries were palpable. There were no problems with durability. New surgical drapes permit observation of the lower extremities during AAR for early diagnosis and treatment of peripheral TE.

  17. The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.

    PubMed

    Schramm, N L; McDonald, M P; Limbird, L E

    2001-07-01

    The noradrenergic system is involved in the regulation of many physiological and psychological processes, including the modulation of mood. The alpha(2)-adrenergic receptors (alpha(2)-ARs) modulate norepinephrine release, as well as the release of serotonin and other neurotransmitters, and are therefore potential targets for antidepressant and anxiolytic drug development. The current studies were undertaken to examine the role of the alpha(2A) subtype of alpha(2)-AR in mouse behavioral models of depression and anxiety. We have observed that the genetic knock-out of the alpha(2A)-AR makes mice less active in a modified version of Porsolt's forced swim test and insensitive to the antidepressant effects of the tricyclic drug imipramine in this paradigm. Furthermore, alpha(2A)-AR knock-out mice appear more anxious than wild-type C57 Bl/6 mice in the rearing and light-dark models of anxiety after injection stress. These findings suggest that the alpha(2A)-AR may play a protective role in some forms of depression and anxiety and that the antidepressant effects of imipramine may be mediated by the alpha(2A)-AR.

  18. Rocket-Based Combined Cycle Engine Concept Development

    NASA Technical Reports Server (NTRS)

    Ratekin, G.; Goldman, Allen; Ortwerth, P.; Weisberg, S.; McArthur, J. Craig (Technical Monitor)

    2001-01-01

    The development of rocket-based combined cycle (RBCC) propulsion systems is part of a 12 year effort under both company funding and contract work. The concept is a fixed geometry integrated rocket, ramjet, scramjet, which is hydrogen fueled and uses hydrogen regenerative cooling. The baseline engine structural configuration uses an integral structure that eliminates panel seals, seal purge gas, and closeout side attachments. Engine A5 is the current configuration for NASA Marshall Space Flight Center (MSFC) for the ART program. Engine A5 models the complete flight engine flowpath of inlet, isolator, airbreathing combustor, and nozzle. High-performance rocket thrusters are integrated into the engine enabling both low speed air-augmented rocket (AAR) and high speed pure rocket operation. Engine A5 was tested in GASL's new Flight Acceleration Simulation Test (FAST) facility in all four operating modes, AAR, RAM, SCRAM, and Rocket. Additionally, transition from AAR to RAM and RAM to SCRAM was also demonstrated. Measured performance demonstrated vision vehicle performance levels for Mach 3 AAR operation and ramjet operation from Mach 3 to 4. SCRAM and rocket mode performance was above predictions. For the first time, testing also demonstrated transition between operating modes.

  19. Analysis of a tobacco vector and its actions in china: the activities of japan tobacco

    PubMed Central

    2010-01-01

    Japan Tobacco (JT) is the third largest tobacco company in the world, and China, the world's largest tobacco consumer, is one of the most important targets for JT. To provide information for tobacco control, we reviewed and analyzed JT and its tactics and strategies in the Chinese market mainly by systematic examination of documents which are made available in the University of California, San Francisco Legacy Tobacco Documents Library. As a result, JT has had a special interest to expand sales of its cigarettes in the Chinese market. PMID:20979655

  20. Utility of feeding jejunostomy tubes in pancreaticoduodenectomy.

    PubMed

    Waliye, Hussein E; Wright, G Paul; McCarthy, Caitlin; Johnson, Jared; Scales, Alex; Wolf, Andrea; Chung, Mathew

    2017-03-01

    Routine placement of jejunostomy tubes (JT) during pancreaticoduodenectomy (PD) is controversial. A retrospective chart review of patients undergoing PD from 1/1/08 through 12/31/14 was performed. The patients were divided into groups by placement of JT. Outcome measures were 90-day morbidity, 90-day mortality, length of stay, rate of delayed gastric emptying (DGE), and JT-specific complications. 256 patients were included. There were no significant differences in 90-day morbidity (39.9% vs. 37.9%, p = 0.747), 90-day mortality (3.9% vs. 1.0%, p = 0.247) or TPN use (24.8 vs. 25.2%, p = 0.941) between those with and without JT, respectively. Patients with a JT had a higher rate of DGE (p < 0.001), longer hospital stay (14.3 vs. 11.6, p < 0.001), and longer time to solid intake (9.4 vs. 7.3, p < 0.001). Eleven patients (7.2%) with JT had tube-related morbidity. Routine placement of JT at the time of PD should be abandoned with efforts focused on preoperative nutrition optimization and early oral diet trials. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. ARC-2001-ACD01-0018

    NASA Image and Video Library

    2001-02-16

    New Center Network Deployment ribbon Cutting: from left to right: Maryland Edwards, Code JT upgrade project deputy task manager; Ed Murphy, foundry networks systems engineer; Bohdan Cmaylo, Code JT upgrade project task manager, Scott Santiago, Division Chief, Code JT; Greg Miller, Raytheon Network engineer and Frank Daras, Raytheon network engineering manager.

  2. 77 FR 10406 - Airworthiness Directives; The Boeing Company Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... powered by Pratt & Whitney JT9D series engines require installation of a new bracket for stowing the... serviceable stowage bracket for the deactivation pins on all airplanes powered by Pratt & Whitney JT9D series... Pratt & Whitney JT9D series engines require installation of a new bracket for stowing the deactivation...

  3. SU-E-T-187: Feasibility Study of Stereotactic Liver Radiation Therapy Using Multiple Divided Partial Arcs in Volumetric Modulated Arc Therapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lin, Y; Ozawa, S; Tsegmed, U

    2014-06-01

    Purpose: To verify volumetric modulated arc therapy (VMAT) using flattening filter free (FFF) mode with jaw tracking (JT) feature for single breath hold as long as 15 s per arc in liver stereotactic body radiation therapy (SBRT) against intensity modulated radiation therapy (IMRT) FFF-JT. Methods: Ten hepatocellular carcinoma (HCC) cases were planned with 10 MV FFF using Pinnacle3 treatment planning system which delivered by TrueBeam to administer 48 Gy/ 4 fractions. Eight non-coplanar beams were assigned to IMRT using step-and-shoot technique. For VMAT, two or three non-coplanar partial arcs (up to 180 degrees) were further divided into subarcs with gantrymore » rotation less than 80 degrees to limit delivery time within 15 s. Dose distributions were verified using OCTAVIUS II system and pass rates were evaluated using gamma analysis with criteria of 3%/3 mm at threshold of 5% to the maximum dose. The actual irradiation time was measured. Results: The VMAT-FFF-JT of partial-arcs with sub-divided arcs was able to produce a highly conformal plan as well as IMRT-FFF-JT. Isodose lines and DVH showed slight improvement in dosimetry when JT was employed for both IMRT and VMAT. Consequently, VMAT-FFF-JT was superior in reducing the dose to liver minus gross tumor volume. VMAT-FFF-JT has shorter total treatment time compared with 3D conformal radiation therapy (3D-CRT) FFF because the gantry was rotated simultaneously with the beam delivery in VMAT. Moreover, due to the small and regular shape of HCC, VMAT-FFF-JT offered less multileaf collimator motion, thus the interplay effect is expected to be reduced. The patient specific QA of IMRT and VMAT acquired the pass rates higher than 90%. Conclusion: VMAT-FFF-JT could be a promising technique for liver SBRT as the sub-divided arcs method was able to accommodate a single breath hold irradiation time of less than 15 s without deterioration of the dose distribution compared with IMRT-FFF-JT.« less

  4. Tricyclic antidepressants exhibit variable pharmacological profiles at the α2A adrenergic receptor

    PubMed Central

    Cottingham, Christopher; Percival, Stefanie; Birky, Tana; Wang, Qin

    2014-01-01

    Antidepressant mechanisms of action remain shrouded in mystery, greatly hindering our ability to develop therapeutics which can fully treat patients suffering from depressive disorders. In an attempt to shed new light on this topic, we have undertaken a series of studies investigating actions of tricyclic antidepressant drugs (TCAs) at the α2A adrenergic receptor (AR), a centrally important receptor, dysregulation of which has been linked to depression. Our previous work established a particular TCA, desipramine, as an arrestin-biased α2AAR ligand driving receptor endocytosis and downregulation but not canonical heterotrimeric G protein-mediated signaling. The present work is aimed at broadening our understanding of how members of the TCA drug class act at the α2AAR, as we have selected the closely related but subtly different TCAs imipramine and amitriptyline for evaluation. Our data demonstrate that these drugs do also function as direct arrestin-biased α2AAR ligands. However, these data reveal differences in receptor affinity and in the extent/nature of arrestin recruitment to and endocytosis of α2AARs. Specifically, amitriptyline exhibits an approximately 14-fold stronger interaction with the receptor, is a weaker driver of arrestin recruitment, and preferentially recruits a different arrestin subtype. Extent of endocytosis is similar for all TCAs studied so far, and occurs in an arrestin-dependent manner, although imipramine uniquely retains a slight ability to drive α2AAR endocytosis in arrestin-null cells. These findings signify an important expansion of our mechanistic understanding of antidepressant pharmacology, and provide useful insights for future medicinal chemistry efforts. PMID:25128275

  5. Area at risk can be assessed by iodine-123-meta-iodobenzylguanidine single-photon emission computed tomography after myocardial infarction: a prospective study.

    PubMed

    Hedon, Christophe; Huet, Fabien; Ben Bouallegue, Fayçal; Vernhet, Hélène; Macia, Jean-Christophe; Cung, Thien-Tri; Leclercq, Florence; Cade, Stéphane; Cransac, Frédéric; Lattuca, Benoit; Vandenberghe, D'Arcy; Bourdon, Aurélie; Benkiran, Meriem; Vauchot, Fabien; Gervasoni, Richard; D'estanque, Emmanuel; Mariano-Goulart, Denis; Roubille, François

    2018-02-01

    Myocardial salvage is an important surrogate endpoint to estimate the impact of treatments in patients with ST-segment elevation myocardial infarction (STEMI). The aim of this study was to evaluate the correlation between cardiac sympathetic denervation area assessed by single-photon emission computed tomography (SPECT) using iodine-123-meta-iodobenzylguanidine (I-MIBG) and myocardial area at risk (AAR) assessed by cardiac magnetic resonance (CMR) (gold standard). A total of 35 postprimary reperfusion STEMI patients were enrolled prospectively to undergo SPECT using I-MIBG (evaluates cardiac sympathetic denervation) and thallium-201 (evaluates myocardial necrosis), and to undergo CMR imaging using T2-weighted spin-echo turbo inversion recovery for AAR and postgadolinium T1-weighted phase sensitive inversion recovery for scar assessment. I-MIBG imaging showed a wider denervated area (51.1±16.0% of left ventricular area) in comparison with the necrosis area on thallium-201 imaging (16.1±14.4% of left ventricular area, P<0.0001). CMR and SPECT provided similar evaluation of the transmural necrosis (P=0.10) with a good correlation (R=0.86, P<0.0001). AAR on CMR was not different compared with the denervated area (P=0.23) and was adequately correlated (R=0.56, P=0.0002). Myocardial salvage evaluated by SPECT imaging (mismatch denervated but viable myocardium) was significantly higher than by CMR (P=0.02). In patients with STEMI, I-MIBG SPECT, assessing cardiac sympathetic denervation may precisely evaluate the AAR, providing an alternative to CMR for AAR assessment.

  6. Analysis of Feedback in after Action Reviews

    DTIC Science & Technology

    1987-06-01

    CONNTSM Page INTRODUCTIUN . . . . . . . . . . . . . . . . . . . A Perspective on Feedback. . ....... • • ..... • 1 Overviev of %,•urrent Research...part of their training program . The AAR is in marked contrast to the critique method of feedback which is often used in military training. The AAR...feedback is task-inherent feedback. Task-inherent feedback refers to human-machine interacting systems, e.g., computers , where in a visual tracking task

  7. Learning in the thick of it.

    PubMed

    Darling, Marilyn; Parry, Charles; Moore, Joseph

    2005-01-01

    The U.S. Army's Opposing Force (OPFOR) is a 2,500-member brigade whose job is to help prepare soldiers for combat. Created to be the meanest, toughest foe that soldiers will ever face, OPFOR engages units-in-training in a variety of mock campaigns under a wide range of conditions. Every month, a fresh brigade of more than 4,000 soldiers takes on this standing enemy. OPFOR, which is stationed in the California desert, always has the home-court advantage. But the force being trained--called BLU FOR--is numerically and technologically superior. It possesses more resources and better, more available data. It is made up of experienced soldiers. And it knows just what to expect, because OPFOR shares its methods from previous campaigns with BLUFOR's commanders. In short, each BLUFOR brigade is given practically every edge. Yet OPFOR almost always wins. Underlying OPFOR's consistent success is the way it uses the after-action review (AAR), a method for extracting lessons from one event or project and applying them to others. AAR meetings became a popular business tool after Shell Oil began experimenting with them in 1998. Most corporate AARs, however, are faint echoes of the rigorous reviews performed by OPFOR. Companies tend to treat the process as a pro-forma wrap-up, drawing lessons from an action but rarely learning them. OPFOR's AARs, by contrast, generate raw material that is fed back into the execution cycle. And while OPFOR's reviews extract numerous lessons, the brigade does not consider a lesson to be learned until it is successfully applied and validated. It might not make sense for companies to adopt OPFOR's AAR processes in their entirety, but four fundamentals are mandatory: Lessons must benefit the team that extracts them. The AAR process must start atthe beginning of the activity. Lessons must link explicitly to future actions. And leaders must hold everyone, especially themselves, accountable for learning.

  8. Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia

    PubMed Central

    Chu, Louis M.; Robich, Michael P.; Bianchi, Cesario; Feng, Jun; Liu, Yuhong; Xu, Shu-Hua; Burgess, Thomas

    2012-01-01

    The cardiovascular effects of cyclooxygenase (COX) inhibition remain controversial, especially in the setting of cardiovascular comorbidities. We examined the effects of nonselective and selective COX inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia. Twenty-four intact male Yorkshire swine underwent left circumflex ameroid constrictor placement and were subsequently given either no drug (HCC; n = 8), a nonselective COX inhibitor (440 mg/day naproxen; HCNS; n = 8), or a selective COX-2 inhibitor (200 mg/day celecoxib; HCCX; n = 8). After 7 wk, myocardial functional was measured and myocardium from the nonischemic ventricle and ischemic area-at-risk (AAR) were analyzed. Regional function as measured by segmental shortening was improved in the AAR of HCCX compared with HCC. There was no significant difference in perfusion to the nonischemic ventricle between groups, but myocardial perfusion in the AAR was significantly improved in the HCCX group compared with controls at rest and during pacing. Endothelium-dependent microvessel relaxation was diminished by ischemia in HCC animals, but both naproxen and celecoxib improved vessel relaxation in the AAR compared with controls, and also decreased the vasoconstrictive response to serotonin. Thromboxane levels in the AAR were decreased in both HCNS and HCCX compared with HCC, whereas prostacyclin levels were decreased only in HCNS, corresponding to a decrease in prostacyclin synthase expression. Chronic ischemia increased apoptosis in Troponin T negative cells and intramyocardial fibrosis, both of which were reduced by celecoxib administration in the AAR. Capillary density was decreased in both the HCNS and HCCX groups. Protein oxidative stress was decreased in both HCNS and HCCX, whereas lipid oxidative stress was decreased only in the HCCX group. Thus nonselective and especially selective COX inhibition may have beneficial myocardial effects in the setting of

  9. Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia.

    PubMed

    Chu, Louis M; Robich, Michael P; Bianchi, Cesario; Feng, Jun; Liu, Yuhong; Xu, Shu-Hua; Burgess, Thomas; Sellke, Frank W

    2012-01-01

    The cardiovascular effects of cyclooxygenase (COX) inhibition remain controversial, especially in the setting of cardiovascular comorbidities. We examined the effects of nonselective and selective COX inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia. Twenty-four intact male Yorkshire swine underwent left circumflex ameroid constrictor placement and were subsequently given either no drug (HCC; n = 8), a nonselective COX inhibitor (440 mg/day naproxen; HCNS; n = 8), or a selective COX-2 inhibitor (200 mg/day celecoxib; HCCX; n = 8). After 7 wk, myocardial functional was measured and myocardium from the nonischemic ventricle and ischemic area-at-risk (AAR) were analyzed. Regional function as measured by segmental shortening was improved in the AAR of HCCX compared with HCC. There was no significant difference in perfusion to the nonischemic ventricle between groups, but myocardial perfusion in the AAR was significantly improved in the HCCX group compared with controls at rest and during pacing. Endothelium-dependent microvessel relaxation was diminished by ischemia in HCC animals, but both naproxen and celecoxib improved vessel relaxation in the AAR compared with controls, and also decreased the vasoconstrictive response to serotonin. Thromboxane levels in the AAR were decreased in both HCNS and HCCX compared with HCC, whereas prostacyclin levels were decreased only in HCNS, corresponding to a decrease in prostacyclin synthase expression. Chronic ischemia increased apoptosis in Troponin T negative cells and intramyocardial fibrosis, both of which were reduced by celecoxib administration in the AAR. Capillary density was decreased in both the HCNS and HCCX groups. Protein oxidative stress was decreased in both HCNS and HCCX, whereas lipid oxidative stress was decreased only in the HCCX group. Thus nonselective and especially selective COX inhibition may have beneficial myocardial effects in the setting of

  10. Electric potential structures of auroral acceleration region border from multi-spacecraft Cluster data

    NASA Astrophysics Data System (ADS)

    Sadeghi, S.; Emami, M. R.

    2018-04-01

    This paper studies an auroral event using data from three spacecraft of the Cluster mission, one inside and two at the poleward edge of the bottom of the Auroral Acceleration Region (AAR). The study reveals the three-dimensional profile of the region's poleward boundary, showing spatial segmentation of the electric potential structures and their decay in time. It also depicts localized magnetic field variations and field-aligned currents that appear to have remained stable for at least 80 s. Such observations became possible due to the fortuitous motion of the three spacecraft nearly parallel to each other and tangential to the AAR edge, so that the differences and variations can be seen when the spacecraft enter and exit the segmentations, hence revealing their position with respect to the AAR.

  11. The growing pipeline of natural aminoacyl-tRNA synthetase inhibitors for malaria treatment

    PubMed Central

    Saint-Léger, Adélaïde; Sinadinos, Christopher; Ribas de Pouplana, Lluís

    2016-01-01

    ABSTRACT Malaria remains a major global health problem. Parasite resistance to existing drugs makes development of new antimalarials an urgency. The protein synthesis machinery is an excellent target for the development of new anti-infectives, and aminoacyl-tRNA synthetases (aaRS) have been validated as antimalarial drug targets. However, avoiding the emergence of drug resistance and improving selectivity to target aaRS in apicomplexan parasites, such as Plasmodium falciparum, remain crucial challenges. Here we discuss such issues using examples of known inhibitors of P. falciparum aaRS, namely halofuginone, cladosporin and borrelidin (inhibitors of ProRS, LysRS and ThrRS, respectively). Encouraging recent results provide useful guidelines to facilitate the development of novel drug candidates which are more potent and selective against these essential enzymes. PMID:26963157

  12. Study of turbofan engines designed for low energy consumption

    NASA Technical Reports Server (NTRS)

    Gray, D. E.

    1976-01-01

    The near-term technology improvements which can reduce the fuel consumed in the JT9D, JT8D, and JT3D turbofans in commercial fleet operation through the 1980's are identified. Projected technology advances are identified and evaluated for new turbofans to be developed after 1985. Programs are recommended for developing the necessary technology.

  13. Exploring Multitarget Interactions to Reduce Opiate Withdrawal Syndrome and Psychiatric Comorbidity

    PubMed Central

    2013-01-01

    Opioid addiction is often characterized as a chronic relapsing condition due to the severe somatic and behavioral signs, associated with depressive disorders, triggered by opiate withdrawal. Since prolonged abstinence remains a major challenge, our interest has been addressed to such objective. Exploring multitarget interactions, the present investigation suggests that 3 or its (S)-enantiomer and 4, endowed with effective α2C-AR agonism/α2A-AR antagonism/5-HT1A-R agonism, or 7 and 9–11 producing efficacious α2C-AR agonism/α2A-AR antagonism/I2–IBS interaction might represent novel multifunctional tools potentially useful for reducing withdrawal syndrome and associated depression. Such agents, lacking in sedative side effects due to their α2A-AR antagonism, might afford an improvement over current therapies with clonidine-like drugs. PMID:24900763

  14. Properties of Gas Mixtures and Their Use in Mixed-Refrigerant Joule-Thomson Refrigerators

    NASA Astrophysics Data System (ADS)

    Luo, E.; Gong, M.; Wu, J.; Zhou, Y.

    2004-06-01

    The Joule-Thomson (J-T) effect has been widely used for achieving low temperatures. In the past few years, much progress has been made in better understanding the working mechanism of the refrigeration method and in developing prototypes for different applications. In this talk, there are three aspects of our research work to be discussed. First, some special thermal properties of the mixtures for achieving liquid nitrogen temperature range will be presented. Secondly, some important conclusions from the optimization of various mixed-refrigerant J-T cycles such as a simple J-T cycle and an auto-cascade mixed-refrigerant J-T cycle will be presented. Moreover, an auto-cascade, mixed-refrigerant J-T refrigerator with a special mixture capable of achieving about 50K will be mentioned. Finally, various prototypes based on the mixed-refrigerant refrigeration technology will be described. These applications include miniature J-T cryocoolers for cooling infrared detectors and high-temperature superconducting devices, cryosurgical knife for medical treatment, low-temperature refrigerators for biological storage and so forth. The on-going research work and unanswered questions for this technology will be also discussed.

  15. Phase 2 program on ground test of refanned JT8D turbofan engines and nacelles for the 727 airplane. Volume 4: Airplane evaluation and analysis

    NASA Technical Reports Server (NTRS)

    1975-01-01

    The retrofit of JT8D-109 (refan) engines are evaluated on a 727-200 airplane in terms of airworthiness, performance, and noise. Design of certifiable hardware, manufacture, and ground testing of the essential nacelle components is included along with analysis of the certifiable airplane design to ensure airworthiness compliance and to predict the in-flight performance and noise characteristics of the modified airplane. The analyses confirm that the 727 refan airplane is certifiable. The refan airplane range would be 15% less that of the baseline airplane and block fuel would be increased by 1.5% to 3%. However, with this particular 727-200 model, with a brake release gross weight of 172,500 lb (78,245 kg), it is possible to operate the airplane (with minor structural modifications) at higher gross weights and increase the range up to 15% over the 727-200 (baseline) airplane. The refan airplane FAR Part 36 noise levels would be 6 to 8 EPNdB (effective perceived noise in decibels) below the baseline. Noise footprint studies showed that approach noise contour areas are small compared to takeoff areas. The 727 refan realizes a 68% to 83% reduction in annoyance-weighted area when compared to the 727-200 over a range of gross weights and operational procedures.

  16. A Survey of Serious Aircraft Accidents Involving Fatigue Fracture. Volume 1. Fixed-Wing Aircraft (Etude sur des Accidents Importants d’Avions du aux Effets des Fractures de Fatigue. Volume 1. Effets sur des Avions).

    DTIC Science & Technology

    1983-04-01

    Bureau of Standards. NTS3 National Transportation Safety Board (USA). NTSB AAR NTSB Aircraft Accident Report. NZ AAR New Zealand Aircraft Accident Report...NZ AI New Zealand Accident Investigation Bureau. 0 -5- RAN Royal Australian Navy RAAI Royal Australian Air Force RAF Royal Air Force, UK S Substantial...Ice land Iraq Ireland Jamaica (1966 -1981) Japan (1973 - Feb. 81) Kenya Lethoso Malaysia Ma law i Mal ta Mexico Netherlands New Zealand Norway

  17. Technology Assessment of the DACS/MERADCOM Prestaged Ammunition Loading System (PALS) Concept Study.

    DTIC Science & Technology

    1980-08-01

    American Railroads (AAR) and Coast 1-2 Arthurl) little.lnc - Guard (CC) regulations for the shipment of ammunition. The system must be compatible with...to meet Association of American Railroads (AAR) and Coast Guard (CC) regulations for the shipment of ammunition. The system must be compatible with...unloaded u ler field conditions? (4) Can the PALS meet AA and CC regulations for the safe shipment of ammunition in commercial cargo containers? (5

  18. A miniature Joule-Thomson cooler for optical detectors in space.

    PubMed

    Derking, J H; Holland, H J; Tirolien, T; ter Brake, H J M

    2012-04-01

    The utilization of single-stage micromachined Joule-Thomson (JT) coolers for cooling small optical detectors is investigated. A design of a micromachined JT cold stage-detector system is made that focuses on the interface between a JT cold stage and detector, and on the wiring of the detector. Among various techniques, adhesive bonding is selected as most suitable technique for integrating the detector with the JT cold stage. Also, the optimum wiring of the detector is discussed. In this respect, it is important to minimize the heat conduction through the wiring. Therefore, each wire should be optimized in terms of acceptable impedance and thermal heat load. It is shown that, given a certain impedance, the conductive heat load of electrically bad conducting materials is about twice as high as that of electrically good conducting materials. A micromachined JT cold stage is designed and integrated with a dummy detector. The JT cold stage is operated at 100 K with nitrogen as the working fluid and at 140 K with methane. Net cooling powers of 143 mW and 117 mW are measured, respectively. Taking into account a radiative heat load of 40 mW, these measured values make the JT cold stage suitable for cooling a photon detector with a power dissipation up to 50 mW, allowing for another 27 to 53 mW heat load arising from the electrical leads. © 2012 American Institute of Physics

  19. Ridge Tectonics, Magma Supply, and Ridge-Hotpot Interaction at the Eastern End of the Australian-Antarctic Ridge

    NASA Astrophysics Data System (ADS)

    Kim, S.; Lin, J.; Park, S.; Choi, H.; Lee, S.

    2013-12-01

    During 2011-2013 the Korea Polar Research Institute (KOPRI) conducted three successive expeditions to the eastern end of the Australian-Antarctic Ridge (AAR) to investigate the tectonics, geochemistry, and hydrothermal activity of this intermediate fast spreading system. On board the Korean icebreaker R/V Araon, the science party collected multiple types of data including multibeam bathymetry, gravity, magnetics, as well as rock and water column samples. In addition, Miniature Autonomous Plume Recorders (MAPRs) were deployed at each of the wax-core rock sampling sites to detect the presence of active hydrothermal vents. In this study, we present a detailed analysis of a 360-km-long super-segment at the eastern end of the AAR to quantify the spatial variations in ridge morphology and investigate its respond to changes in melt supply. The study region contains several intriguing bathymetric features including (1) abrupt changes in the axial topography, alternating between rift valleys and axial highs within relatively short ridge segments; (2) overshooting ridge tips at the ridge-transform intersections; (3) systematic migration patterns of hooked ridges; (4) a 350-km-long mega-transform fault; and (5) robust axial and off-axis volcanisms. To obtain a proxy for regional variations in magma supply, we calculated residual mantle Bouguer gravity anomalies (RMBA), gravity-derived crustal thickness, and residual topography for seven sub-segments. The results of the analyses revealed that the southern flank of the AAR is associated with a shallower seafloor, more negative RMBA, thicker crust, and/or less dense mantle than the conjugate northern flank. Furthermore, this N-S asymmetry becomes more prominent toward the super-segment of the AAR. Such regional variations in seafloor topography and RMBA are consistent with the hypothesis that ridge segments in the study area have interacted with the Balleny hotspot, currently lies southwest of the AAR. However, the influence of

  20. Biodistribution and Safety Assessment of Bladder Cancer Specific Recombinant Oncolytic Adenovirus in Subcutaneous Xenografts Tumor Model in Nude Mice

    PubMed Central

    Wang, Fang; Wang, Zhiping; Tian, Hongwei; Qi, Meijiao; Zhai, Zhenxing; Li, Shuwen; Li, Renju; Zhang, Hongjuan; Wang, Wenyun; Fu, Shenjun; Lu, Jianzhong; Rodriguez, Ronald; Guo, Yinglu; Zhou, Liqun

    2012-01-01

    Background The previous works about safety evaluation for constructed bladder tissue specific adenovirus are poorly documented. Thus, we investigated the biodistribution and body toxicity of bladder specific oncolytic adenovirus Ad-PSCAE-UPII-E1A (APU-E1A) and Ad-PSCAE-UPII-E1A-AR (APU-E1A-AR), providing meaningful information prior to embarking on human clinical trials. Materials and Method Conditionally replicate recombinant adenovirus (CRADs) APU-E1A, APU-EIA-AR were constructed with bladder tissue specific Uroplakin II (UP II) promoter to induce the expression of Ad5E1A gene and E1A-AR fusing gene, and PSCAE was inserted at upstream of promoter to enhance the function of promoter. Based on the cytopathic and anti-tumor effect of bladder cancer, these CRADs were intratumorally injected into subcutaneous xenografts tumor in nude mice. We then determined the toxicity through general health and behavioral assessment, hepatic and hematological toxicity evaluation, macroscopic and microscopic postmortem analyses. The spread of the transgene E1A of adenovirus was detected with RT-PCR and Western blot. Virus replication and distribution were examined with APU-LUC administration and Luciferase Assay. Results General assessment and body weight of the animals did not reveal any alteration in general behavior. The hematological alterations of groups which were injected with 5×108 pfu or higher dose (5×109 pfu) of APU-E1A and APU-E1A-AR showed no difference in comparison with PBS group, and only slight increased transaminases in contrast to PBS group at 5×109 pfu of APU-E1A and APU-E1A-AR were observed. E1A transgene did not disseminate to organs outside of xenograft tumor. Virus replication was not detected in other organs beside tumor according to Luciferase Assay. Conclusions Our study showed that recombinant adenovirus APU-E1A-AR and APU-E1A appear safe with 5×107 pfu and 5×108 pfu intratumorally injection in mice, without any discernable effects on general health

  1. Biodistribution and safety assessment of bladder cancer specific recombinant oncolytic adenovirus in subcutaneous xenografts tumor model in nude mice.

    PubMed

    Wang, Fang; Wang, Zhiping; Tian, Hongwei; Qi, Meijiao; Zhai, Zhenxing; Li, Shuwen; Li, Renju; Zhang, Hongjuan; Wang, Wenyun; Fu, Shenjun; Lu, Jianzhong; Rodriguez, Ronald; Guo, Yinglu; Zhou, Liqun

    2012-04-01

    The previous works about safety evaluation for constructed bladder tissue specific adenovirus are poorly documented. Thus, we investigated the biodistribution and body toxicity of bladder specific oncolytic adenovirus Ad-PSCAE-UPII-E1A (APU-E1A) and Ad-PSCAE-UPII-E1A-AR (APU-E1A-AR), providing meaningful information prior to embarking on human clinical trials. Conditionally replicate recombinant adenovirus (CRADs) APU-E1A, APU-EIA-AR were constructed with bladder tissue specific UroplakinII(UPII) promoter to induce the expression of Ad5E1A gene and E1A-AR fusing gene, and PSCAE was inserted at upstream of promoter to enhance the function of promoter. Based on the cytopathic and anti-tumor effect of bladder cancer, these CRADs were intratumorally injected into subcutaneous xenografts tumor in nude mice. We then determined the toxicity through general health and behavioral assessment, hepatic and hematological toxicity evaluation, macroscopic and microscopic postmortem analyses. The spread of the transgene E1A of adenovirus was detected with RT-PCR and Western blot. Virus replication and distribution were examined with APU-LUC administration and Luciferase Assay. General assessment and body weight of the animals did not reveal any alteration in general behavior. The hematological alterations of groups which were injected with 5x10(8) pfu or higher dose (5x10(9) pfu) of APU-E1A and APU-E1A-AR showed no difference in comparison with PBS group, and only slight increased transaminases in contrast to PBS group at 5x10(9) pfu of APU-E1A and APU-E1A-AR were observed. E1A transgene did not disseminate to organs outside of xenograft tumor. Virus replication was not detected in other organs beside tumor according to Luciferase Assay. Our study showed that recombinant adenovirus APU-E1A-AR and APU-E1A appear safe with 5x10(7) pfu and 5x10(8) pfu intratumorally injection in mice, without any discernable effects on general health and behavior.

  2. Attenuation of alpha2A-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood.

    PubMed

    Shishkina, G T; Kalinina, T S; Dygalo, N N

    2004-01-01

    Brain alpha2-adrenergic receptors (alpha2-ARs) have been implicated in the regulation of anxiety, which is associated with stress. Environmental treatments during neonatal development could modulate the level of brain alpha2-AR expression and alter anxiety in adults, suggesting possible involvement of these receptors in early-life programming of anxiety state. The present study was undertaken to determine whether the reduction of the expression of A subtype of these receptors most abundant in the neonatal brain affects anxiety-related behavior in adulthood. We attenuated the expression of alpha2A-ARs during neonatal life by two different sequence specific approaches, antisense technology and RNA interference. Treatment of rats with the antisense oligodeoxynucleotide or short interfering RNA (siRNA) against alpha2A-ARs on the days 2-4 of their life, produced a marked acute decrease in the levels of both alpha2A-AR mRNA and [3H]RX821002 binding sites in the brainstem into which drugs were injected. The decrease of alpha2A-AR expression in the neonatal brainstem influenced the development of this receptor system in the brain regions as evidenced by the increased number of [3H]RX821002 binding sites in the hypothalamus of adult animals with both neonatal alpha2A-AR knockdown treatments; also in the frontal cortex of antisense-treated, and in the hippocampus of siRNA-treated adult rats. These adult animals also demonstrated a decreased anxiety in the elevated plus-maze as evidenced by an increased number of the open arm entries, greater proportion of time spent in the open arms, and more than a two-fold increase in the number of exploratory head dips. The results provide the first evidence that the reduction in the brain expression of a gene encoding for alpha2A-AR during neonatal life led to the long-term neurochemical and behavioral alterations. The data suggests that alterations in the expression of the receptor-specific gene during critical periods of brain

  3. Influence of jaw tracking in intensity-modulated and volumetric-modulated arc radiotherapy for head and neck cancers: a dosimetric study.

    PubMed

    Mani, Karthick Raj; Upadhayay, Sagar; Das, K J Maria

    2017-03-01

    To Study the dosimetric advantage of the Jaw tracking technique in intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) for Head and Neck Cancers. We retrospectively selected 10 previously treated head and neck cancer patients stage (T1/T2, N1, M0) in this study. All the patients were planned for IMRT and VMAT with simultaneous integrated boost technique. IMRT and VMAT plans were performed with jaw tracking (JT) and with static jaw (SJ) technique by keeping the same constraints and priorities for a particular patient. Target conformity, dose to the critical structures and low dose volumes were recorded and analyzed for IMRT and VMAT plans with and without JT for all the patients. The conformity index average of all patients followed by standard deviation ([Formula: see text] ± [Formula: see text]) of the JT-IMRT, SJ-IMRT, JT-VMAT, and SJ-VMAT were 1.72 ± 0.56, 1.67 ± 0.57, 1.83 ± 0.65, and 1.85 ± 0.64, and homogeneity index were 0.059 ± 0.05, 0.064 ± 0.05, 0.064 ± 0.04, and 0.064 ± 0.05. JT-IMRT shows significant mean reduction in right parotid and left parotid shows of 7.64% (p < 0.001) and 7.45% (p < 0.001) compare to SJ-IMRT. JT-IMRT plans also shows considerable dose reduction to thyroid, inferior constrictors, spinal cord and brainstem compared to the SJ-IMRT plans. Significant dose reductions were observed for critical structure in the JT-IMRT compared to SJ-IMRT technique. In JT-VMAT plans dose reduction to the critical structure were not significant compared to the SJ-IMRT due to relatively lesser monitor units.

  4. Streptomyces colonosanans sp. nov., A Novel Actinobacterium Isolated from Malaysia Mangrove Soil Exhibiting Antioxidative Activity and Cytotoxic Potential against Human Colon Cancer Cell Lines

    PubMed Central

    Law, Jodi Woan-Fei; Ser, Hooi-Leng; Duangjai, Acharaporn; Saokaew, Surasak; Bukhari, Sarah I.; Khan, Tahir M.; Ab Mutalib, Nurul-Syakima; Chan, Kok-Gan; Goh, Bey-Hing; Lee, Learn-Han

    2017-01-01

    Streptomyces colonosanans MUSC 93JT, a novel strain isolated from mangrove forest soil located at Sarawak, Malaysia. The bacterium was noted to be Gram-positive and to form light yellow aerial and vivid yellow substrate mycelium on ISP 2 agar. The polyphasic approach was used to determine the taxonomy of strain MUSC 93JT and the strain showed a range of phylogenetic and chemotaxonomic properties consistent with those of the members of the genus Streptomyces. Phylogenetic and 16S rRNA gene sequence analysis indicated that closely related strains include Streptomyces malachitofuscus NBRC 13059T (99.2% sequence similarity), Streptomyces misionensis NBRC 13063T (99.1%), and Streptomyces phaeoluteichromatogenes NRRL 5799T (99.1%). The DNA–DNA relatedness values between MUSC 93JT and closely related type strains ranged from 14.4 ± 0.1 to 46.2 ± 0.4%. The comparison of BOX-PCR fingerprints indicated MUSC 93JT exhibits a unique DNA profile. The genome of MUSC 93JT consists of 7,015,076 bp. The DNA G + C content was determined to be 69.90 mol%. The extract of strain MUSC 93JT was demonstrated to exhibit potent antioxidant activity via ABTS, metal chelating, and SOD assays. This extract also exhibited anticancer activity against human colon cancer cell lines without significant cytotoxic effect against human normal colon cells. Furthermore, the chemical analysis of the extract further emphasizes the strain is producing chemo-preventive related metabolites. Based on this polyphasic study of MUSC 93JT, it is concluded that this strain represents a novel species, for which the name Streptomyces colonosanans sp. nov. is proposed. The type strain is MUSC 93JT (= DSM 102042T = MCCC 1K02298T). PMID:28559892

  5. When Will We Ever Learn? The After Action Review, Lessons Learned and the Next Steps in Training and Educating the Homeland Security Enterprise for the 21st Century

    DTIC Science & Technology

    2013-06-01

    Evaluation Program (HSEEP), Volume III, February 2007, 27. 29 Ibid., 4. 30 Ibid. 12 …allows players to engage in a self -assessment of their...be correct in one respect. A 2003 paper entitled A Comparative Study of the After Action Review (AAR) in the Context of the Southern Africa Crisis...A Comparative Study of the After Action Review (AAR) in the Context of the Southern Africa Crisis, June 2003. 46 Ibid. 47 Human Factors Integration

  6. Functional Dissection of the Bipartite Active Site of the Class I Coenzyme A (CoA)-Transferase Succinyl-CoA:Acetate CoA-Transferase.

    PubMed

    Murphy, Jesse R; Mullins, Elwood A; Kappock, T Joseph

    2016-01-01

    Coenzyme A (CoA)-transferases catalyze the reversible transfer of CoA from acyl-CoA thioesters to free carboxylates. Class I CoA-transferases produce acylglutamyl anhydride intermediates that undergo attack by CoA thiolate on either the internal or external carbonyl carbon atoms, forming distinct tetrahedral intermediates <3 Å apart. In this study, crystal structures of succinyl-CoA:acetate CoA-transferase (AarC) from Acetobacter aceti are used to examine how the Asn347 carboxamide stabilizes the internal oxyanion intermediate. A structure of the active mutant AarC-N347A bound to CoA revealed both solvent replacement of the missing contact and displacement of the adjacent Glu294, indicating that Asn347 both polarizes and orients the essential glutamate. AarC was crystallized with the nonhydrolyzable acetyl-CoA (AcCoA) analog dethiaacetyl-CoA (1a) in an attempt to trap a closed enzyme complex containing a stable analog of the external oxyanion intermediate. One active site contained an acetylglutamyl anhydride adduct and truncated 1a, an unexpected result hinting at an unprecedented cleavage of the ketone moiety in 1a. Solution studies confirmed that 1a decomposition is accompanied by production of near-stoichiometric acetate, in a process that seems to depend on microbial contamination but not AarC. A crystal structure of AarC bound to the postulated 1a truncation product (2a) showed complete closure of one active site per dimer but no acetylglutamyl anhydride, even with acetate added. These findings suggest that an activated acetyl donor forms during 1a decomposition; a working hypothesis involving ketone oxidation is offered. The ability of 2a to induce full active site closure furthermore suggests that it subverts a system used to impede inappropriate active site closure on unacylated CoA.

  7. Functional Dissection of the Bipartite Active Site of the Class I Coenzyme A (CoA)-Transferase Succinyl-CoA:Acetate CoA-Transferase

    PubMed Central

    Murphy, Jesse R.; Mullins, Elwood A.; Kappock, T. Joseph

    2016-01-01

    Coenzyme A (CoA)-transferases catalyze the reversible transfer of CoA from acyl-CoA thioesters to free carboxylates. Class I CoA-transferases produce acylglutamyl anhydride intermediates that undergo attack by CoA thiolate on either the internal or external carbonyl carbon atoms, forming distinct tetrahedral intermediates <3 Å apart. In this study, crystal structures of succinyl-CoA:acetate CoA-transferase (AarC) from Acetobacter aceti are used to examine how the Asn347 carboxamide stabilizes the internal oxyanion intermediate. A structure of the active mutant AarC-N347A bound to CoA revealed both solvent replacement of the missing contact and displacement of the adjacent Glu294, indicating that Asn347 both polarizes and orients the essential glutamate. AarC was crystallized with the nonhydrolyzable acetyl-CoA (AcCoA) analog dethiaacetyl-CoA (1a) in an attempt to trap a closed enzyme complex containing a stable analog of the external oxyanion intermediate. One active site contained an acetylglutamyl anhydride adduct and truncated 1a, an unexpected result hinting at an unprecedented cleavage of the ketone moiety in 1a. Solution studies confirmed that 1a decomposition is accompanied by production of near-stoichiometric acetate, in a process that seems to depend on microbial contamination but not AarC. A crystal structure of AarC bound to the postulated 1a truncation product (2a) showed complete closure of one active site per dimer but no acetylglutamyl anhydride, even with acetate added. These findings suggest that an activated acetyl donor forms during 1a decomposition; a working hypothesis involving ketone oxidation is offered. The ability of 2a to induce full active site closure furthermore suggests that it subverts a system used to impede inappropriate active site closure on unacylated CoA. PMID:27242998

  8. Automatic localization of IASLC-defined mediastinal lymph node stations on CT images using fuzzy models

    NASA Astrophysics Data System (ADS)

    Matsumoto, Monica M. S.; Beig, Niha G.; Udupa, Jayaram K.; Archer, Steven; Torigian, Drew A.

    2014-03-01

    Lung cancer is associated with the highest cancer mortality rates among men and women in the United States. The accurate and precise identification of the lymph node stations on computed tomography (CT) images is important for staging disease and potentially for prognosticating outcome in patients with lung cancer, as well as for pretreatment planning and response assessment purposes. To facilitate a standard means of referring to lymph nodes, the International Association for the Study of Lung Cancer (IASLC) has recently proposed a definition of the different lymph node stations and zones in the thorax. However, nodal station identification is typically performed manually by visual assessment in clinical radiology. This approach leaves room for error due to the subjective and potentially ambiguous nature of visual interpretation, and is labor intensive. We present a method of automatically recognizing the mediastinal IASLC-defined lymph node stations by modifying a hierarchical fuzzy modeling approach previously developed for body-wide automatic anatomy recognition (AAR) in medical imagery. Our AAR-lymph node (AAR-LN) system follows the AAR methodology and consists of two steps. In the first step, the various lymph node stations are manually delineated on a set of CT images following the IASLC definitions. These delineations are then used to build a fuzzy hierarchical model of the nodal stations which are considered as 3D objects. In the second step, the stations are automatically located on any given CT image of the thorax by using the hierarchical fuzzy model and object recognition algorithms. Based on 23 data sets used for model building, 22 independent data sets for testing, and 10 lymph node stations, a mean localization accuracy of within 1-6 voxels has been achieved by the AAR-LN system.

  9. Automated Quantification of Myocardial Salvage in a Rat Model of Ischemia–Reperfusion Injury Using 3D High‐Resolution Magnetic Resonance Imaging (MRI)

    PubMed Central

    Grieve, Stuart M.; Mazhar, Jawad; Callaghan, Fraser; Kok, Cindy Y.; Tandy, Sarah; Bhindi, Ravinay; Figtree, Gemma A.

    2014-01-01

    Background Quantification of myocardial “area at risk” (AAR) and myocardial infarction (MI) zone is critical for assessing novel therapies targeting myocardial ischemia–reperfusion (IR) injury. Current “gold‐standard” methods perfuse the heart with Evan's Blue and stain with triphenyl tetrazolium chloride (TTC), requiring manual slicing and analysis. We aimed to develop and validate a high‐resolution 3‐dimensional (3D) magnetic resonance imaging (MRI) method for quantifying MI and AAR. Methods and Results Forty‐eight hours after IR was induced, rats were anesthetized and gadopentetate dimeglumine was administered intravenously. After 10 minutes, the coronary artery was re‐ligated and a solution containing iron oxide microparticles and Evan's Blue was infused (for comparison). Hearts were harvested and transversally sectioned for TTC staining. Ex vivo MR images of slices were acquired on a 9.4‐T magnet. T2* data allowed visualization of AAR, with microparticle‐associated signal loss in perfused regions. T1 data demonstrated gadolinium retention in infarcted zones. Close correlation (r=0.92 to 0.94; P<0.05) of MRI and Evan's Blue/TTC measures for both AAR and MI was observed when the combined techniques were applied to the same heart slice. However, 3D MRI acquisition and analysis of whole heart reduced intra‐observer variability compared to assessment of isolated slices, and allowed automated segmentation and analysis, thus reducing interobserver variation. Anatomical resolution of 81 μm3 was achieved (versus ≈2 mm with manual slicing). Conclusions This novel, yet simple, MRI technique allows precise assessment of infarct and AAR zones. It removes the need for tissue slicing and provides opportunity for 3D digital analysis at high anatomical resolution in a streamlined manner accessible for all laboratories already performing IR experiments. PMID:25146703

  10. Accuracy of Area at Risk Quantification by Cardiac Magnetic Resonance According to the Myocardial Infarction Territory.

    PubMed

    Fernández-Friera, Leticia; García-Ruiz, José Manuel; García-Álvarez, Ana; Fernández-Jiménez, Rodrigo; Sánchez-González, Javier; Rossello, Xavier; Gómez-Talavera, Sandra; López-Martín, Gonzalo J; Pizarro, Gonzalo; Fuster, Valentín; Ibáñez, Borja

    2017-05-01

    Area at risk (AAR) quantification is important to evaluate the efficacy of cardioprotective therapies. However, postinfarction AAR assessment could be influenced by the infarcted coronary territory. Our aim was to determine the accuracy of T 2 -weighted short tau triple-inversion recovery (T 2 W-STIR) cardiac magnetic resonance (CMR) imaging for accurate AAR quantification in anterior, lateral, and inferior myocardial infarctions. Acute reperfused myocardial infarction was experimentally induced in 12 pigs, with 40-minute occlusion of the left anterior descending (n = 4), left circumflex (n = 4), and right coronary arteries (n = 4). Perfusion CMR was performed during selective intracoronary gadolinium injection at the coronary occlusion site (in vivo criterion standard) and, additionally, a 7-day CMR, including T 2 W-STIR sequences, was performed. Finally, all animals were sacrificed and underwent postmortem Evans blue staining (classic criterion standard). The concordance between the CMR-based criterion standard and T 2 W-STIR to quantify AAR was high for anterior and inferior infarctions (r = 0.73; P = .001; mean error = 0.50%; limits = -12.68%-13.68% and r = 0.87; P = .001; mean error = -1.5%; limits = -8.0%-5.8%, respectively). Conversely, the correlation for the circumflex territories was poor (r = 0.21, P = .37), showing a higher mean error and wider limits of agreement. A strong correlation between pathology and the CMR-based criterion standard was observed (r = 0.84, P < .001; mean error = 0.91%; limits = -7.55%-9.37%). T 2 W-STIR CMR sequences are accurate to determine the AAR for anterior and inferior infarctions; however, their accuracy for lateral infarctions is poor. These findings may have important implications for the design and interpretation of clinical trials evaluating the effectiveness of cardioprotective therapies. Copyright © 2016 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  11. Geophysical Characteristics of the Australian-Antarctic Ridge

    NASA Astrophysics Data System (ADS)

    Kim, S. S.; Lin, J.; Park, S. H.; Choi, H.; Lee, S. M.

    2014-12-01

    Between 2011 and 2013, the Korea Polar Research Institute (KOPRI) conducted three consecutive geologic surveys at the little explored eastern ends of the Australian-Antarctic Ridge (AAR) to characterize the tectonics, geochemistry, and hydrothermal activity of this intermediate spreading system. Using the Korean icebreaker R/V Araon, the multi-disciplinary research team collected bathymetry, gravity, magnetics, and rock and water column samples. In addition, Miniature Autonomous Plume Recorders (MAPRs) were deployed at wax-core rock sampling sites to detect the presence of active hydrothermal vents. Here we present a detailed analysis of a 300-km-long supersegment of the AAR to quantify the spatial variations in ridge morphology and robust axial and off-axis volcanisms. The ridge axis morphology alternates between rift valleys and axial highs within relatively short ridge segments. To obtain a geological proxy for regional variations in magma supply, we calculated residual mantle Bouguer gravity anomalies (RMBA), gravity-derived crustal thickness, and residual topography for seven sub-segments. The results of the analyses revealed that the southern flank of the AAR is associated with shallower seafloor, more negative RMBA, thicker crust, and/or less dense mantle than the conjugate northern flank. Furthermore, this north-south asymmetry becomes more prominent toward the KR1 supersegment of the AAR. The axial topography of the KR1 supersegment exhibits a sharp transition from axial highs at the western end to rift valleys at the eastern end, with regions of axial highs being associated with more magma supply as indicated by more negative RMBA. We also compare and contrast the characteristics of the AAR supersegment with that of other ridges of intermediate spreading rates, including the Juan de Fuca Ridge, Galápagos Spreading Center, and Southeast Indian Ridge west of the Australian-Antarctic Discordance, to investigate the influence of ridge-hotspot interaction on

  12. Functional dissection of the bipartite active site of the class I coenzyme A (CoA)-transferase succinyl-CoA:acetate CoA-transferase

    DOE PAGES

    Murphy, Jesse R.; Mullins, Elwood A.; Kappock, T. Joseph

    2016-05-23

    Coenzyme A (CoA)-transferases catalyze the reversible transfer of CoA from acyl-CoA thioesters to free carboxylates. Class I CoA-transferases produce acylglutamyl anhydride intermediates that undergo attack by CoA thiolate on either the internal or external carbonyl carbon atoms, forming distinct tetrahedral intermediates <3 Å apart. Here in this study, crystal structures of succinyl-CoA:acetate CoA-transferase (AarC) from Acetobacter aceti are used to examine how the Asn347 carboxamide stabilizes the internal oxyanion intermediate. A structure of the active mutant AarC-N347A bound to CoA revealed both solvent replacement of the missing contact and displacement of the adjacent Glu294, indicating that Asn347 both polarizes andmore » orients the essential glutamate. AarC was crystallized with the nonhydrolyzable acetyl-CoA (AcCoA) analog dethiaacetyl-CoA (1a) in an attempt to trap a closed enzyme complex containing a stable analog of the external oxyanion intermediate. One active site contained an acetylglutamyl anhydride adduct and truncated 1a, an unexpected result hinting at an unprecedented cleavage of the ketone moiety in 1a. Solution studies confirmed that 1a decomposition is accompanied by production of near-stoichiometric acetate, in a process that seems to depend on microbial contamination but not AarC. A crystal structure of AarC bound to the postulated 1a truncation product (2a) showed complete closure of one active site per dimer but no acetylglutamyl anhydride, even with acetate added. These findings suggest that an activated acetyl donor forms during 1a decomposition; a working hypothesis involving ketone oxidation is offered. Finally, the ability of 2a to induce full active site closure furthermore suggests that it subverts a system used to impede inappropriate active site closure on unacylated CoA.« less

  13. α(2A)-adrenergic receptors filter parabrachial inputs to the bed nucleus of the stria terminalis.

    PubMed

    Flavin, Stephanie A; Matthews, Robert T; Wang, Qin; Muly, E Chris; Winder, Danny G

    2014-07-09

    α2-adrenergic receptors (AR) within the bed nucleus of the stria terminalis (BNST) reduce stress-reward interactions in rodent models. In addition to their roles as autoreceptors, BNST α(2A)-ARs suppress glutamatergic transmission. One prominent glutamatergic input to the BNST originates from the parabrachial nucleus (PBN) and consists of asymmetric axosomatic synapses containing calcitonin gene-related peptide (CGRP) and vGluT2. Here we provide immunoelectron microscopic data showing that many asymmetric axosomatic synapses in the BNST contain α(2A)-ARs. Further, we examined optically evoked glutamate release ex vivo in BNST from mice with virally delivered channelrhodopsin2 (ChR2) expression in PBN. In BNST from these animals, ChR2 partially colocalized with CGRP, and activation generated EPSCs in dorsal anterolateral BNST neurons that elicited two cell-type-specific outcomes: (1) feedforward inhibition or (2) an EPSP that elicited firing. We found that the α(2A)-AR agonist guanfacine selectively inhibited this PBN input to the BNST, preferentially reducing the excitatory response in ex vivo mouse brain slices. To begin to assess the overall impact of α(2A)-AR control of this PBN input on BNST excitatory transmission, we used a Thy1-COP4 mouse line with little postsynaptic ChR2 expression nor colocalization of ChR2 with CGRP in the BNST. In slices from these mice, we found that guanfacine enhanced, rather than suppressed, optogenetically initiated excitatory drive in BNST. Thus, our study reveals distinct actions of PBN afferents within the BNST and suggests that α(2A)-AR agonists may filter excitatory transmission in the BNST by inhibiting a component of the PBN input while enhancing the actions of other inputs. Copyright © 2014 the authors 0270-6474/14/349319-13$15.00/0.

  14. Positron emission tomography (PET) imaging of prostate cancer with a gastrin releasing peptide receptor antagonist--from mice to men.

    PubMed

    Wieser, Gesche; Mansi, Rosalba; Grosu, Anca L; Schultze-Seemann, Wolfgang; Dumont-Walter, Rebecca A; Meyer, Philipp T; Maecke, Helmut R; Reubi, Jean Claude; Weber, Wolfgang A

    2014-01-01

    Ex vivo studies have shown that the gastrin releasing peptide receptor (GRPr) is overexpressed on almost all primary prostate cancers, making it a promising target for prostate cancer imaging and targeted radiotherapy. Biodistribution, dosimetry and tumor uptake of the GRPr antagonist ⁶⁴Cu-CB-TE2A-AR06 [(⁶⁴Cu-4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo(6.6.2)hexadecane)-PEG₄-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-LeuNH₂] were studied by PET/CT in four patients with newly diagnosed prostate cancer (T1c-T2b, Gleason 6-7). No adverse events were observed after injection of ⁶⁴Cu-CB-TE2A-AR06. Three of four tumors were visualized with high contrast [tumor-to-prostate ratio > 4 at 4 hours (h) post injection (p.i.)], one small tumor (T1c, < 5% tumor on biopsy specimens) showed moderate contrast (tumor-to-prostate ratio at 4 h: 1.9). Radioactivity was cleared by the kidneys and only the pancreas demonstrated significant accumulation of radioactivity, which rapidly decreased over time. ⁶⁴Cu-CB-TE2A-AR06 shows very favorable characteristics for imaging prostate cancer. Future studies evaluating ⁶⁴Cu-CB-TE2A-AR06 PET/CT for prostate cancer detection, staging, active surveillance, and radiation treatment planning are necessary.

  15. Probing catalytic rate enhancement during intramembrane proteolysis.

    PubMed

    Arutyunova, Elena; Smithers, Cameron C; Corradi, Valentina; Espiritu, Adam C; Young, Howard S; Tieleman, D Peter; Lemieux, M Joanne

    2016-09-01

    Rhomboids are ubiquitous intramembrane serine proteases involved in various signaling pathways. While the high-resolution structures of the Escherichia coli rhomboid GlpG with various inhibitors revealed an active site comprised of a serine-histidine dyad and an extensive oxyanion hole, the molecular details of rhomboid catalysis were unclear because substrates are unknown for most of the family members. Here we used the only known physiological pair of AarA rhomboid with its psTatA substrate to decipher the contribution of catalytically important residues to the reaction rate enhancement. An MD-refined homology model of AarA was used to identify residues important for catalysis. We demonstrated that the AarA active site geometry is strict and intolerant to alterations. We probed the roles of H83 and N87 oxyanion hole residues and determined that substitution of H83 either abolished AarA activity or reduced the transition state stabilization energy (ΔΔG‡) by 3.1 kcal/mol; substitution of N87 decreased ΔΔG‡ by 1.6-3.9 kcal/mol. Substitution M154, a residue conserved in most rhomboids that stabilizes the catalytic general base, to tyrosine, provided insight into the mechanism of nucleophile generation for the catalytic dyad. This study provides a quantitative evaluation of the role of several residues important for hydrolytic efficiency and oxyanion stabilization during intramembrane proteolysis.

  16. Automatic anatomy recognition on CT images with pathology

    NASA Astrophysics Data System (ADS)

    Huang, Lidong; Udupa, Jayaram K.; Tong, Yubing; Odhner, Dewey; Torigian, Drew A.

    2016-03-01

    Body-wide anatomy recognition on CT images with pathology becomes crucial for quantifying body-wide disease burden. This, however, is a challenging problem because various diseases result in various abnormalities of objects such as shape and intensity patterns. We previously developed an automatic anatomy recognition (AAR) system [1] whose applicability was demonstrated on near normal diagnostic CT images in different body regions on 35 organs. The aim of this paper is to investigate strategies for adapting the previous AAR system to diagnostic CT images of patients with various pathologies as a first step toward automated body-wide disease quantification. The AAR approach consists of three main steps - model building, object recognition, and object delineation. In this paper, within the broader AAR framework, we describe a new strategy for object recognition to handle abnormal images. In the model building stage an optimal threshold interval is learned from near-normal training images for each object. This threshold is optimally tuned to the pathological manifestation of the object in the test image. Recognition is performed following a hierarchical representation of the objects. Experimental results for the abdominal body region based on 50 near-normal images used for model building and 20 abnormal images used for object recognition show that object localization accuracy within 2 voxels for liver and spleen and 3 voxels for kidney can be achieved with the new strategy.

  17. Carcass and meat quality of Assaf milk fed lambs: Effect of rearing system and sex.

    PubMed

    Rodríguez, A B; Landa, R; Bodas, R; Prieto, N; Mantecón, A R; Giráldez, F J

    2008-10-01

    The effect of sex and rearing system on growth and carcass and meat characteristics of milk fed Assaf lambs was studied. Thirty-six lambs, 18 males and 18 females were used. Twelve lambs remained with their mothers throughout the experiment (NR). Within 24-36h of birth, the rest were housed individually and fed twice a day ad libitum (AAR) or at 70% of ad libitum consumption (RAR) with reconstituted cow's milk. Sex did not affect animal performance, yet females showed higher carcass and non-carcass fat deposits. NR lambs showed greater BWG than AAR fed lambs, and AAR, higher than the RAR. Differences between naturally and artificially reared lambs in CCW and killing out percentage were not significant. Empty digestive tract and mesenteric fat weights were greater for RAR than NR lambs, with the AAR lambs demonstrating intermediate values; conversely, omental fat was greater in NR lambs. Carcass ether extract content was greater for NR lambs, possibly due to the greater growth. Use of ad libitum cow's milk substitute in suckling lambs twice a day resulted in less body weight gain but similar killing out percentages compared to naturally raised lambs. A 70% restricted supply increased the days in suckling and reduced carcass fatness and compactness. Except for water loss, which was less in NR than artificially fed lambs, no differences were found in meat characteristics.

  18. Backbone Brackets and Arginine Tweezers delineate Class I and Class II aminoacyl tRNA synthetases

    PubMed Central

    Haupt, V. Joachim; Schroeder, Michael; Labudde, Dirk

    2018-01-01

    The origin of the machinery that realizes protein biosynthesis in all organisms is still unclear. One key component of this machinery are aminoacyl tRNA synthetases (aaRS), which ligate tRNAs to amino acids while consuming ATP. Sequence analyses revealed that these enzymes can be divided into two complementary classes. Both classes differ significantly on a sequence and structural level, feature different reaction mechanisms, and occur in diverse oligomerization states. The one unifying aspect of both classes is their function of binding ATP. We identified Backbone Brackets and Arginine Tweezers as most compact ATP binding motifs characteristic for each Class. Geometric analysis shows a structural rearrangement of the Backbone Brackets upon ATP binding, indicating a general mechanism of all Class I structures. Regarding the origin of aaRS, the Rodin-Ohno hypothesis states that the peculiar nature of the two aaRS classes is the result of their primordial forms, called Protozymes, being encoded on opposite strands of the same gene. Backbone Brackets and Arginine Tweezers were traced back to the proposed Protozymes and their more efficient successors, the Urzymes. Both structural motifs can be observed as pairs of residues in contemporary structures and it seems that the time of their addition, indicated by their placement in the ancient aaRS, coincides with the evolutionary trace of Proto- and Urzymes. PMID:29659563

  19. The results of a low-speed wind tunnel test to investigate the effects of the Refan JT8D engine target thrust reverser on the stability and control characteristics of the Boeing 727-200 airplane

    NASA Technical Reports Server (NTRS)

    Kupcis, E. A.

    1974-01-01

    The effects of the Refan JT8D side engine target thrust reverser on the stability and control characteristics of the Boeing 727-200 airplane were investigated using the Boeing-Vertol 20 x 20 ft Low-Speed Wind Tunnel. A powered model of the 727-200 was tested in groud effect in the landing configuration. The Refan target reverser configuration was evaluated relative to the basic production 727 airplane with its clamshell-deflector door thrust reverser design. The Refan configuration had slightly improved directional control characteristics relative to the basic airplane. Clocking the Refan thrust reversers 20 degrees outboard to direct the reverser flow away from the vertical tail, had little effect on directional control. However, clocking them 20 degrees inboard resulted in a complete loss of rudder effectiveness for speeds greater than 90 knots. Variations in Refan reverser lip/fence geometry had a minor effect on directional control.

  20. Quantification of myocardial area at risk in the absence of collateral flow: the validation of angiographic scores by myocardial perfusion single-photon emission computed tomography.

    PubMed

    Rodríguez-Palomares, José F; Alonso, Albert; Martí, Gerard; Aguadé-Bruix, Santiago; González-Alujas, M T; Romero-Farina, Guillermo; Candell-Riera, Jaume; García del Blanco, Bruno; Evangelista, Artur; García-Dorado, David

    2013-02-01

    Our study aimed to compare the area at risk (AAR) determined by single-photon emission computed tomography (SPECT) with the Bypass Angioplasty Revascularization Investigation (BARI) and modified Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) angiographic scores in the setting of patients undergoing coronary angioplasty for either unstable angina or an STEMI. Radionuclide myocardial perfusion imaging prior to reperfusion has classically been the most widely practised technique for assessing the AAR and has been successfully used to compare the efficacy of various reperfusion strategies in patients with an ST-segment elevation myocardial infarction (STEMI). The BARI and modified APPROACH scores are angiographic methods widely used to provide a rapid estimation of the AAR; however, they have not been directly validated with myocardial perfusion single-photon emission computed tomography (SPECT). Fifty-five patients with no previous myocardial infarction who underwent coronary angioplasty for single-vessel disease (unstable angina: n = 25 or an STEMI: n = 30) with no evidence of collaterals (Rentrop Collateral Score <2) were included in a prospective study. In STEMI patients, the (99m)Tc-tetrofosmin was injected prior to opening of the occluded vessel and, in patients with unstable angina after 10-15 seconds of balloon inflation. Acquisition was performed with a dual-head gammacamera with a low-energy and high-resolution collimator. A total of 60 projections were acquired using a non-circular orbit. No attenuation or scatter correction was used. Maximal contours of hypoperfusion regions corresponding to each coronary artery occlusion were delineated over a polar map of 17 segments and compared with the estimated AAR determined by two experienced interventional cardiologists using both angiographic scores. Mean AAR percentage in SPECT was 35.0 (10.0%-56.0%). A high correlation was found between BARI and APPROACH scores (r = 0.9, P

  1. EPR Studies of orthorhombic Jahn-Teller effect in single crystal of ferroelectric Cu(II):Cd2(NH4)2 (SO4)3

    NASA Astrophysics Data System (ADS)

    Benson, Yerima; de, Dilip

    In this paper we report the first EPR observation and theoretical explanation of orthorhombic Jahn-Teller effect in Cu(II) doped single crystal of ferroelectric cadmium ammonium sulphate: Cu(II):Cd2(NH4)2 (SO4)3 . The isotropic EPR spectra of the 2D ion (in regular octahedral symmetry) at higher temperature becomes anisotropic at low temperature with clear manifestation of orthorhombic g and hyperfine tensors at 15 K. The static Jahn-Teller(JT) effect can only be explained theoretically by assuming the three JT potential wells energetically inequivalent, unlike the potential wells in most of the Cu(II) doped crystalline materials where JT effect manifests. The measured splitting of the JT potential wells in this ferroelectric crystal fall in the sub millimeter wave region pointing to possible application of the material.

  2. Opportunities Missed: A Cross-Sectional Survey of the Provision of Smoking Cessation Care to Pregnant Women by Australian General Practitioners and Obstetricians.

    PubMed

    Zeev, Yael Bar; Bonevski, Billie; Twyman, Laura; Watt, Kerrianne; Atkins, Lou; Palazzi, Kerrin; Oldmeadow, Christopher; Gould, Gillian S

    2017-05-01

    Similar to other high-income countries, smoking rates in pregnancy can be high in specific vulnerable groups in Australia. Several clinical guidelines exist, including the 5A's (Ask, Advice, Assess, Assist, and Arrange), ABCD (Ask, Brief advice, Cessation, and Discuss), and AAR (Ask, Advice, and Refer). There is lack of data on provision of smoking cessation care (SCC) of Australian General Practitioners (GPs) and Obstetricians. A cross-sectional survey explored the provision of SCC, barriers and enablers using the Theoretical Domains Framework, and the associations between them. Two samples were invited: (1) GPs and Obstetricians from a college database (n = 5571); (2) GPs from a special interest group for Indigenous health (n = 500). Dimension reduction for the Theoretical Domains Framework was achieved with factor analysis. Logistic regression was carried out for performing all the 5A's and the AAR. Performing all of the 5A's, ABCD, and AAR "often and always" was reported by 19.9%, 15.6%, and 49.2% respectively. "Internal influences" (such as confidence in counselling) were associated with higher performance of the 5A's (Adjusted OR 2.69 (95% CI 1.5, 4.8), p < .001), whereas "External influences" (such as workplace routine) were associated with higher performance of AAR (Adjusted OR 1.7 (95% CI 1, 2.8), p = .035). Performance in providing SCC to pregnant women is low among Australian GPs and Obstetricians. Training clinicians should focus on improving internal influences such as confidence and optimism. The AAR may be easier to implement, and interventions at the service level should focus on ensuring easy, effective, and acceptable referral mechanisms are in place. Improving provision of the 5A's approach should focus on the individual level, including better training for GPs and Obstetricians, designed to improve specific "internal" barriers such as confidence in counselling and optimism. The AAR may be easier to implement in view of the higher overall

  3. Tobacco users' perceptions of a brief tobacco cessation intervention in community pharmacies.

    PubMed

    Patwardhan, Pallavi D; Chewning, Betty A

    2010-01-01

    To explore factors affecting tobacco users' perceived appropriateness of a brief and proactive tobacco cessation counseling program, ask, advise, and refer (AAR), at community pharmacies. Inductive thematic analysis. Southern Wisconsin during fall 2008. 24 tobacco users who had recently received brief and proactive tobacco cessation counseling at a community pharmacy. Semistructured telephone interviews conducted by primary author. Perceptions of a brief and proactive tobacco cessation counseling program conducted at community pharmacies. In conducting the thematic analysis, eight distinct themes were identified. Display of information and resources at pharmacies for use by tobacco users as needed was identified as the most predominant theme and was found to be most helpful by many respondents. Other themes identified in decreasing order of prevalence were: tobacco users' perceptions of the role of pharmacists in health care, tobacco users' belief that smoking could interact with a current medication or health condition, tobacco users' sensitivity toward their tobacco use behavior or being told what to do, nonconfrontational and friendly approach of pharmacists, tobacco users' readiness to quit at the time of AAR counseling, tobacco user initiation of tobacco use discussion, and tobacco users' belief that tobacco use is bad. Overall, this qualitative investigation suggests that several factors might influence tobacco users' perceived appropriateness of AAR counseling at community pharmacies. AAR might be well received by tobacco users and pharmacy patrons as long as it is done in a professional and respectful manner.

  4. Automatic anatomy recognition using neural network learning of object relationships via virtual landmarks

    NASA Astrophysics Data System (ADS)

    Yan, Fengxia; Udupa, Jayaram K.; Tong, Yubing; Xu, Guoping; Odhner, Dewey; Torigian, Drew A.

    2018-03-01

    The recently developed body-wide Automatic Anatomy Recognition (AAR) methodology depends on fuzzy modeling of individual objects, hierarchically arranging objects, constructing an anatomy ensemble of these models, and a dichotomous object recognition-delineation process. The parent-to-offspring spatial relationship in the object hierarchy is crucial in the AAR method. We have found this relationship to be quite complex, and as such any improvement in capturing this relationship information in the anatomy model will improve the process of recognition itself. Currently, the method encodes this relationship based on the layout of the geometric centers of the objects. Motivated by the concept of virtual landmarks (VLs), this paper presents a new one-shot AAR recognition method that utilizes the VLs to learn object relationships by training a neural network to predict the pose and the VLs of an offspring object given the VLs of the parent object in the hierarchy. We set up two neural networks for each parent-offspring object pair in a body region, one for predicting the VLs and another for predicting the pose parameters. The VL-based learning/prediction method is evaluated on two object hierarchies involving 14 objects. We utilize 54 computed tomography (CT) image data sets of head and neck cancer patients and the associated object contours drawn by dosimetrists for routine radiation therapy treatment planning. The VL neural network method is found to yield more accurate object localization than the currently used simple AAR method.

  5. Study of Noise-Certification Standards for Aircraft Engines. Volume 2. Procedures for Measuring Far Field Sound Pressure Levels around an Outdoor Jet-Engine Test Stand.

    DTIC Science & Technology

    1983-06-01

    60 References ........................................................... 79 AccesSqlon For NTIS rFA&I r"!’ TAU U: .,P Dist r A. -. S iv...separate exhaust nozzles for discharge of fan and turbine exhaust flows (e.g., JT15D, TFE731 , ALF-502, CF34, JT3D, CFM56, RB.211, CF6, JT9D, and PW2037...minimum radial distance from the effective source of sound at 40 Hz should then be approxi- mately 69 m. At 60 Hz, the minimum radial distance should be

  6. Genetics Home Reference: multiple familial trichoepithelioma

    MedlinePlus

    ... 13. Citation on PubMed Bowen S, Gill M, Lee DA, Fisher G, Geronemus RG, Vazquez ME, Celebi JT. ... Fernandez-Figueras, Maria Tereza]. Citation on PubMed Lee DA, Grossman ME, Schneiderman P, Celebi JT. Genetics of ...

  7. Genetics Home Reference: Brooke-Spiegler syndrome

    MedlinePlus

    ... article on PubMed Central Bowen S, Gill M, Lee DA, Fisher G, Geronemus RG, Vazquez ME, Celebi JT. ... 124(5):919-20. Citation on PubMed Lee DA, Grossman ME, Schneiderman P, Celebi JT. Genetics of ...

  8. Insulin-Increased L-Arginine Transport Requires A2A Adenosine Receptors Activation in Human Umbilical Vein Endothelium

    PubMed Central

    Guzmán-Gutiérrez, Enrique; Westermeier, Francisco; Salomón, Carlos; González, Marcelo; Pardo, Fabián; Leiva, Andrea; Sobrevia, Luis

    2012-01-01

    Adenosine causes vasodilation of human placenta vasculature by increasing the transport of arginine via cationic amino acid transporters 1 (hCAT-1). This process involves the activation of A2A adenosine receptors (A2AAR) in human umbilical vein endothelial cells (HUVECs). Insulin increases hCAT-1 activity and expression in HUVECs, and A2AAR stimulation increases insulin sensitivity in subjects with insulin resistance. However, whether A2AAR plays a role in insulin-mediated increase in L-arginine transport in HUVECs is unknown. To determine this, we first assayed the kinetics of saturable L-arginine transport (1 minute, 37°C) in the absence or presence of nitrobenzylthioinosine (NBTI, 10 µmol/L, adenosine transport inhibitor) and/or adenosine receptors agonist/antagonists. We also determined hCAT-1 protein and mRNA expression levels (Western blots and quantitative PCR), and SLC7A1 (for hCAT-1) reporter promoter activity. Insulin and NBTI increased the extracellular adenosine concentration, the maximal velocity for L-arginine transport without altering the apparent K m for L-arginine transport, hCAT-1 protein and mRNA expression levels, and SLC7A1 transcriptional activity. An A2AAR antagonist ZM-241385 blocked these effects. ZM241385 inhibited SLC7A1 reporter transcriptional activity to the same extent in cells transfected with pGL3-hCAT-1−1606 or pGL3-hCAT-1−650 constructs in the presence of NBTI + insulin. However, SLC7A1 reporter activity was increased by NBTI only in cells transfected with pGL3-hCAT-1−1606, and the ZM-241385 sensitive fraction of the NBTI response was similar in the absence or in the presence of insulin. Thus, insulin modulation of hCAT-1 expression and activity requires functional A2AAR in HUVECs, a mechanism that may be applicable to diseases associated with fetal insulin resistance, such as gestational diabetes. PMID:22844517

  9. δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) mediate intermittent hypoxia induced protection of canine myocardium.

    PubMed

    Estrada, Juan A; Williams, Arthur G; Sun, Jie; Gonzalez, Leticia; Downey, H Fred; Caffrey, James L; Mallet, Robert T

    2016-03-01

    Intermittent, normobaric hypoxia confers robust cardioprotection against ischemia-induced myocardial infarction and lethal ventricular arrhythmias. δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) have been implicated in cardioprotective phenomena, but their roles in intermittent hypoxia are unknown. This study examined the contributions of DOR and ROS in mediating intermittent hypoxia-induced cardioprotection. Mongrel dogs completed a 20 day program consisting of 5-8 daily, 5-10 min cycles of moderate, normobaric hypoxia (FIO2 0.095-0.10), with intervening 4 min room air exposures. Subsets of dogs received the DOR antagonist naltrindole (200 μg/kg, sc) or antioxidant N-acetylcysteine (250 mg/kg, po) before each hypoxia session. Twenty-four hours after the last session, the left anterior descending coronary artery was occluded for 60 min and then reperfused for 5 h. Arrhythmias detected by electrocardiography were scored according to the Lambeth II conventions. Left ventricles were sectioned and stained with 2,3,5-triphenyl-tetrazolium-chloride, and infarct sizes were expressed as percentages of the area at risk (IS/AAR). Intermittent hypoxia sharply decreased IS/AAR from 41 ± 5 % (n = 12) to 1.8 ± 0.9 % (n = 9; P < 0.001) and arrhythmia score from 4.1 ± 0.3 to 0.7 ± 0.2 (P < 0.001) vs. non-hypoxic controls. Naltrindole (n = 6) abrogated the cardioprotection with IS/AAR 35 ± 5 % and arrhythmia score 3.7 ± 0.7 (P < 0.001 vs. untreated intermittent hypoxia). N-acetylcysteine (n = 6) interfered to a similar degree, with IS/AAR 42 ± 3 % and arrhythmia score 4.7 ± 0.3 (P < 0.001 vs. untreated intermittent hypoxia). Without the intervening reoxygenations, hypoxia (n = 4) was not cardioprotective (IS/AAR 50 ± 8 %; arrhythmia score 4.5 ± 0.5; P < 0.001 vs. intermittent hypoxia). Thus DOR, ROS and cyclic reoxygenation were obligatory participants in the gradually evolving cardioprotection produced by intermittent hypoxia.

  10. Adaptive Aggregation Routing to Reduce Delay for Multi-Layer Wireless Sensor Networks

    PubMed Central

    Li, Xujing; Xie, Mande; Zeng, Zhiwen; Cai, Zhiping

    2018-01-01

    The quality of service (QoS) regarding delay, lifetime and reliability is the key to the application of wireless sensor networks (WSNs). Data aggregation is a method to effectively reduce the data transmission volume and improve the lifetime of a network. In the previous study, a common strategy required that data wait in the queue. When the length of the queue is greater than or equal to the predetermined aggregation threshold (Nt) or the waiting time is equal to the aggregation timer (Tt), data are forwarded at the expense of an increase in the delay. The primary contributions of the proposed Adaptive Aggregation Routing (AAR) scheme are the following: (a) the senders select the forwarding node dynamically according to the length of the data queue, which effectively reduces the delay. In the AAR scheme, the senders send data to the nodes with a long data queue. The advantages are that first, the nodes with a long data queue need a small amount of data to perform aggregation; therefore, the transmitted data can be fully utilized to make these nodes aggregate. Second, this scheme balances the aggregating and data sending load; thus, the lifetime increases. (b) An improved AAR scheme is proposed to improve the QoS. The aggregation deadline (Tt) and the aggregation threshold (Nt) are dynamically changed in the network. In WSNs, nodes far from the sink have residual energy because these nodes transmit less data than the other nodes. In the improved AAR scheme, the nodes far from the sink have a small value of Tt and Nt to reduce delay, and the nodes near the sink are set to a large value of Tt and Nt to reduce energy consumption. Thus, the end to end delay is reduced, a longer lifetime is achieved, and the residual energy is fully used. Simulation results demonstrate that compared with the previous scheme, the performance of the AAR scheme is improved. This scheme reduces the delay by 14.91%, improves the lifetime by 30.91%, and increases energy efficiency by 76

  11. Body-wide hierarchical fuzzy modeling, recognition, and delineation of anatomy in medical images.

    PubMed

    Udupa, Jayaram K; Odhner, Dewey; Zhao, Liming; Tong, Yubing; Matsumoto, Monica M S; Ciesielski, Krzysztof C; Falcao, Alexandre X; Vaideeswaran, Pavithra; Ciesielski, Victoria; Saboury, Babak; Mohammadianrasanani, Syedmehrdad; Sin, Sanghun; Arens, Raanan; Torigian, Drew A

    2014-07-01

    To make Quantitative Radiology (QR) a reality in radiological practice, computerized body-wide Automatic Anatomy Recognition (AAR) becomes essential. With the goal of building a general AAR system that is not tied to any specific organ system, body region, or image modality, this paper presents an AAR methodology for localizing and delineating all major organs in different body regions based on fuzzy modeling ideas and a tight integration of fuzzy models with an Iterative Relative Fuzzy Connectedness (IRFC) delineation algorithm. The methodology consists of five main steps: (a) gathering image data for both building models and testing the AAR algorithms from patient image sets existing in our health system; (b) formulating precise definitions of each body region and organ and delineating them following these definitions; (c) building hierarchical fuzzy anatomy models of organs for each body region; (d) recognizing and locating organs in given images by employing the hierarchical models; and (e) delineating the organs following the hierarchy. In Step (c), we explicitly encode object size and positional relationships into the hierarchy and subsequently exploit this information in object recognition in Step (d) and delineation in Step (e). Modality-independent and dependent aspects are carefully separated in model encoding. At the model building stage, a learning process is carried out for rehearsing an optimal threshold-based object recognition method. The recognition process in Step (d) starts from large, well-defined objects and proceeds down the hierarchy in a global to local manner. A fuzzy model-based version of the IRFC algorithm is created by naturally integrating the fuzzy model constraints into the delineation algorithm. The AAR system is tested on three body regions - thorax (on CT), abdomen (on CT and MRI), and neck (on MRI and CT) - involving a total of over 35 organs and 130 data sets (the total used for model building and testing). The training and

  12. The Jahn-Teller distortion influenced ferromagnetic order in Pr1-xLaxMnO3

    NASA Astrophysics Data System (ADS)

    He, Feifei; Mao, Zhongquan; Tang, Lingyun; Zhang, Jiang; Chen, Xi

    2018-06-01

    The structural and magnetic properties of Pr1-xLaxMnO3 (0 ≤ x ≤ 1) polycrystalline powders are investigated. A structural phase transition from a large Jahn-Teller (J-T) distorted orthorhombic structure to a small J-T distorted orthorhombic phase is found at x = 0.70, while the LaMnO3 is showed to have a rhombohedral structure. All the samples exhibit ferromagnetic ordering, and meanwhile, a reentrant spin glass behavior at low temperature. The relationship between J-T distortions and the ferromagnetic order is discussed.

  13. Storm-associated Alfvén Waves in the Polar Environment

    NASA Astrophysics Data System (ADS)

    Keiling, A.; Wygant, J. R.; Dombeck, J. P.

    2017-12-01

    Global polar distribution maps of Alfvénic Poynting flux and Alfvén-wave-accelerated electrons now exist from a number of satellites, orbiting at various altitudes, including below and in the auroral acceleration region (AAR), above the AAR and in the equatorial plasma sheet. Together with auroral images, it has been established that the nightside aurora, in particular its premidnight to midnight dominance, is coupled to these waves. Moreover, global simulations have reproduced the observed nightside distribution of Alfvén waves, coming from the far-tail magnetospheric dynamo. While recent studies, using low-altitude and equatorial satellites, have shown a deviation from this average nightside pattern during storm times, as of now there is no such study to provide the link between these regions, namely just above the AAR. In this presentation, we will present Polar spacecraft-based data during storm times, covering the altitude range from 4 to 7 RE (geocentric distance) and spanning a time period of six years. The results will be put in context to published studies, in particular with regard to morphology and dissipation.

  14. Automated Aerial Refueling Hitches a Ride on AFF

    NASA Technical Reports Server (NTRS)

    Hansen, Jennifer L.; Murray, James E.; Bever, Glenn; Campos, Norma V.; Schkolnik, Gerard

    2007-01-01

    The recent introduction of uninhabited aerial vehicles [UAVs (basically, remotely piloted or autonomous aircraft)] has spawned new developments in autonomous operation and posed new challenges. Automated aerial refueling (AAR) is a capability that will enable UAVs to travel greater distances and loiter longer over targets. NASA Dryden Flight Research Center, in cooperation with the Defense Advanced Research Projects Agency (DARPA), the Naval Air Systems Command (NAVAIR), the Naval Air Force Pacific Fleet, and the Air Force Research Laboratory, rapidly conceived and accomplished an AAR flight research project focused on collecting a unique, high-quality database on the dynamics of the hose and drogue of an aerial refueling system. This flight-derived database would be used to validate mathematical models of the dynamics in support of design and analysis of AAR systems for future UAVs. The project involved the use of two Dryden F/A-18 airplanes and an S-3 hose-drogue refueling store on loan from the Navy. In this year-long project, which was started on October 1, 2002, 583 research maneuvers were completed during 23 flights.

  15. Progressive Reduction in Central Blood Volume is not Detected by Sublingual Capnography

    DTIC Science & Technology

    2012-01-01

    Sam Houston; †Department of Health and Kinesiology , University of Texas at San Antonio, San Antonio, and ‡San Antonio Military Medical Center, Fort...of hypovolaemia with gastrointestinal tonometry. Intensive Care Med 23(3):276 281, 1997. 13. Santoso JT, Wisner DH, Battistella FD, Owings JT

  16. Measurement of type-I edge localized mode pulse propagation in scrape-off layer using optical system of motional Stark effect diagnostics in JT-60U

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Suzuki, T.; Oyama, N.; Asakura, N.

    2010-04-15

    Propagation of plasma ejected by type-I edge localized mode (ELM) has been measured in scrape-off layer (SOL) of the JT-60U tokamak, using optical system of motional Stark effect (MSE) diagnostics as beam emission spectroscopy (BES) diagnostics through a new technique developed. This MSE/BES system measures D{alpha} emission from heating neutral beam excited by collisions with the ejected plasma, as well as background light (e.g., bremsstrahlung). While spatio-temporal change in the beam emission gives information on propagation of the ejected plasma, the background light that is observed simultaneously in all spatial channels veils the information. In order to separate the beammore » emission and the background light, a two-wavelength detector is newly introduced into the MSE/BES system. The detector observes simultaneously at the same spatial point in two distinct wavelengths using two photomultiplier tubes through two interference filters. One of the filters is adjusted to the central wavelength of the beam emission for the MSE diagnostics, and the other is outside the beam emission spectrum. Eliminating the background light, temporal change in the net beam emission in the SOL has been evaluated. Comparing conditionally averaged beam emission with respect to 594 ELMs in a discharge at five spatial channels (0.02-0.3 m outside the main plasma near equatorial plane), radial velocity of the ELM pulse propagation in SOL is evaluated to be 0.8-1.8 km/s ({approx}1.4 km/s for least-mean-squared fitting).« less

  17. A Proposal for Qualification Standards as a Contracting Officer in the Naval Facilities Engineering Command.

    DTIC Science & Technology

    1985-06-01

    4. Government Contract Law , DMET PPM 302 (JT); two weeks in length...ccitent: reviews basic legal principles and sources of contract law , modifications, termina- tions, remedies, interpretation of contract language...Governmepnt Contract Law PPM 302 (JT) ____ _____ Recomripnded Optional Courses 1. Advanced Contract Administration PPM 304 (IT) _ ___ _____ 2. Management of

  18. Refan Engine in the Propulsion Systems Laboratory

    NASA Image and Video Library

    1974-10-21

    A refanned Pratt and Whitney JT-8D-109 turbofan engine installed in Cell 4 of the Propulsion Systems Laboratory at the National Aeronautics and Space Administration (NASA) Lewis Research Center. NASA Lewis’ Refan Program sought to demonstrate that noise reduction modifications could be applied to existing aircraft engines with minimal costs and without diminishing the engine’s performance or integrity. At the time, Pratt and Whitney’s JT-8D turbofans were one of the most widely used engines in the commercial airline industry. The engines powered Boeing’s 727 and 737 and McDonnell Douglas’ DC-9 aircraft. Pratt and Whitney worked with the airline manufacturers on a preliminary study that verified feasibility of replacing the JT-8D’s two-stage fan with a larger single-stage fan. The new fan slowed the engine’s exhaust, which significantly reduced the amount of noise it generated. Booster stages were added to maintain the proper level of airflow through the engine. Pratt and Whitney produced six of the modified engines, designated JT-8D-109, and performed the initial testing. One of the JT-8D-109 engines, seen here, was tested in simulated altitude conditions in NASA Lewis’ Propulsion Systems Laboratory. The Refan engine was ground-tested on an actual aircraft before making a series of flight tests on 727 and DC-9 aircraft in early 1976. The Refan Program reduced the JT-8D’s noise by 50 percent while increasing the fuel efficiency. The retro-fit kits were estimated to cost between $1 million and $1.7 million per aircraft.

  19. SU-E-T-125: Application of Jaw-Tracking Function in VMAT for Upper Thoracic Esophageal Cancer

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, W; Chen, J; Zhai, T

    2015-06-15

    Purpose: To explore the effect of the Jaw-tracking with RapidArc(JT-RapidArc) plans for upper thoracic esophageal cancer. Methods: Treatment planning was designed by using RapidArc and JT-RapidArc techniques for 11 consecutive patients. The dose-volume histogram parameters of PTV and the organs at risk(OAR), conformity index(CI), heterogeneity index(HI), low dose volume of normal tissue(B-P) and monitor units(MUs) were compared between the different techniques. Results: JT-RapidArc plans provided the better coverage of PTV1(64) D98 and HI(P<0.05), lower MLD, D2 of PTV1(64) and PTV2(54), but no statistically difference in CI(P>0.05), which comparison with RapidArc plans. Plans with JT- RapidArc had lower Lung of V5,more » V10, V13, V20, V30, MLD(P<0.05); heart of V20, MLD(P<0.05); and B-P of V5, V10, V15, V20, V30(P<0.05); but no significantly different in Spinal cord and SC-PRV as compared with RapidArc plans. JT-RapidArc plans increaseed the MUs by 1%(P>0.05) as compared with RapidArc plans. Conclusion: All of the plans had met the requirements of clinical dosimetry. JT-RapidArc plans as compared with RapidArc plans, showing better part of target coverage, part of OARS(lung and heart) and heart and B-P sparing, which MUs was slightly increased. This work was sponsored by Shantou University Medical College Clinical Research Enhancement Initiative(NO.201424)« less

  20. Adaptive Aggregation Routing to Reduce Delay for Multi-Layer Wireless Sensor Networks.

    PubMed

    Li, Xujing; Liu, Anfeng; Xie, Mande; Xiong, Neal N; Zeng, Zhiwen; Cai, Zhiping

    2018-04-16

    The quality of service (QoS) regarding delay, lifetime and reliability is the key to the application of wireless sensor networks (WSNs). Data aggregation is a method to effectively reduce the data transmission volume and improve the lifetime of a network. In the previous study, a common strategy required that data wait in the queue. When the length of the queue is greater than or equal to the predetermined aggregation threshold ( N t ) or the waiting time is equal to the aggregation timer ( T t ), data are forwarded at the expense of an increase in the delay. The primary contributions of the proposed Adaptive Aggregation Routing (AAR) scheme are the following: (a) the senders select the forwarding node dynamically according to the length of the data queue, which effectively reduces the delay. In the AAR scheme, the senders send data to the nodes with a long data queue. The advantages are that first, the nodes with a long data queue need a small amount of data to perform aggregation; therefore, the transmitted data can be fully utilized to make these nodes aggregate. Second, this scheme balances the aggregating and data sending load; thus, the lifetime increases. (b) An improved AAR scheme is proposed to improve the QoS. The aggregation deadline ( T t ) and the aggregation threshold ( N t ) are dynamically changed in the network. In WSNs, nodes far from the sink have residual energy because these nodes transmit less data than the other nodes. In the improved AAR scheme, the nodes far from the sink have a small value of T t and N t to reduce delay, and the nodes near the sink are set to a large value of T t and N t to reduce energy consumption. Thus, the end to end delay is reduced, a longer lifetime is achieved, and the residual energy is fully used. Simulation results demonstrate that compared with the previous scheme, the performance of the AAR scheme is improved. This scheme reduces the delay by 14.91%, improves the lifetime by 30.91%, and increases energy

  1. U-Series Disequilibria across the New Southern Ocean Mantle Province, Australian-Antarctic Ridge

    NASA Astrophysics Data System (ADS)

    Scott, S. R.; Sims, K. W. W.; Park, S. H.; Langmuir, C. H.; Lin, J.; Kim, S. S.; Blichert-Toft, J.; Michael, P. J.; Choi, H.; Yang, Y. S.

    2017-12-01

    Mid-ocean ridge basalts (MORB) provide a unique window into the temporal and spatial scales of mantle evolution. Long-lived radiogenic isotopes in MORB have demonstrated that the mantle contains many different chemical components or "flavors". U-series disequilibria in MORB have further shown that different chemical components/lithologies in the mantle contribute differently to mantle melting processes beneath mid-ocean ridges. Recent Sr, Nd, Hf, and Pb isotopic analyses from newly collected basalts along the Australian-Antarctic Ridge (AAR) have revealed that a large distinct mantle province exists between the Australian-Antarctic Discordance and the Pacific-Antarctic Ridge, extending from West Antarctica and Marie Byrd Land to New Zealand and Eastern Australia (Park et al., submitted). This southern mantle province is located between the Indian-type mantle and the Pacific-type mantle domains. U-series measurements in the Southeast Indian Ridge and East Pacific Rise provinces show distinct signatures suggestive of differences in melting processes and source lithology. To examine whether the AAR mantle province also exhibits different U-series systematics we have measured U-Th-Ra disequilibria data on 38 basalts from the AAR sampled along 500 km of ridge axis from two segments that cross the newly discovered Southern Ocean Mantle province. We compare the data to those from nearby ridge segments show that the AAR possesses unique U-series disequilibria, and are thus undergoing distinct mantle melting dynamics relative to the adjacent Pacific and Indian ridges. (230Th)/(238U) excesses in zero-age basalts (i.e., those with (226Ra)/(230Th) > 1.0) range from 1.3 to 1.7, while (226Ra)/(230Th) ranges from 1.0 to 2.3. (226Ra)/(230Th) and (230Th)/(238U) are negatively correlated, consistent with the model of mixing between deep and shallow melts. The AAR data show higher values of disequilibria compared to the Indian and Pacific Ridges, which can be explained by either

  2. Ask-Advise-Connect: a new approach to smoking treatment delivery in health care settings.

    PubMed

    Vidrine, Jennifer Irvin; Shete, Sanjay; Cao, Yumei; Greisinger, Anthony; Harmonson, Penny; Sharp, Barry; Miles, Lyndsay; Zbikowski, Susan M; Wetter, David W

    2013-03-25

    Several national health care-based smoking cessation initiatives have been recommended to facilitate the delivery of evidence-based treatments, such as quitline (telephone-based tobacco cessation services) assistance. The most notable examples are the 5 As (Ask, Advise, Assess, Assist, Arrange) and Ask. Advise. Refer. (AAR) programs. Unfortunately, rates of primary care referrals to quitlines are low, and most referred smokers fail to call for assistance. To evaluate a new approach--Ask-Advise-Connect (AAC)--designed to address barriers to linking smokers with treatment. A pair-matched, 2-treatment-arm, group-randomized design in 10 family practice clinics in a single metropolitan area. Five clinics were randomized to the AAC (intervention) and 5 to the AAR (control) conditions. In both conditions, clinic staff were trained to assess and record the smoking status of all patients at all visits in the electronic health record, and smokers were given brief advice to quit. In the AAC clinics, the names and telephone numbers of smokers who agreed to be connected were sent electronically to the quitline daily, and patients were called proactively by the quitline within 48 hours. In the AAR clinics, smokers were offered a quitline referral card and encouraged to call on their own. All data were collected from February 8 through December 27, 2011. Ten clinics in Houston, Texas. Smoking status assessments were completed for 42,277 patients; 2052 unique smokers were identified at AAC clinics, and 1611 smokers were identified at AAR clinics. Linking smokers with quitline-delivered treatment. Impact was based on the RE-AIM (Reach, Efficacy, Adoption, Implementation, and Maintenance) conceptual framework and defined as the proportion of all identified smokers who enrolled in treatment. In the AAC clinics, 7.8% of all identified smokers enrolled in treatment vs 0.6% in the AAR clinics (t4 = 9.19 [P < .001]; odds ratio, 11.60 [95% CI, 5.53-24.32]), a 13-fold increase in the

  3. GPS navigation algorithms for Autonomous Airborne Refueling of Unmanned Air Vehicles

    NASA Astrophysics Data System (ADS)

    Khanafseh, Samer Mahmoud

    Unmanned Air Vehicles (UAVs) have recently generated great interest because of their potential to perform hazardous missions without risking loss of life. If autonomous airborne refueling is possible for UAVs, mission range and endurance will be greatly enhanced. However, concerns about UAV-tanker proximity, dynamic mobility and safety demand that the relative navigation system meets stringent requirements on accuracy, integrity, and continuity. In response, this research focuses on developing high-performance GPS-based navigation architectures for Autonomous Airborne Refueling (AAR) of UAVs. The AAR mission is unique because of the potentially severe sky blockage introduced by the tanker. To address this issue, a high-fidelity dynamic sky blockage model was developed and experimentally validated. In addition, robust carrier phase differential GPS navigation algorithms were derived, including a new method for high-integrity reacquisition of carrier cycle ambiguities for recently-blocked satellites. In order to evaluate navigation performance, world-wide global availability and sensitivity covariance analyses were conducted. The new navigation algorithms were shown to be sufficient for turn-free scenarios, but improvement in performance was necessary to meet the difficult requirements for a general refueling mission with banked turns. Therefore, several innovative methods were pursued to enhance navigation performance. First, a new theoretical approach was developed to quantify the position-domain integrity risk in cycle ambiguity resolution problems. A mechanism to implement this method with partially-fixed cycle ambiguity vectors was derived, and it was used to define tight upper bounds on AAR navigation integrity risk. A second method, where a new algorithm for optimal fusion of measurements from multiple antennas was developed, was used to improve satellite coverage in poor visibility environments such as in AAR. Finally, methods for using data-link extracted

  4. Prior automatic posture and activity identification improves physical activity energy expenditure prediction from hip-worn triaxial accelerometry.

    PubMed

    Garnotel, M; Bastian, T; Romero-Ugalde, H M; Maire, A; Dugas, J; Zahariev, A; Doron, M; Jallon, P; Charpentier, G; Franc, S; Blanc, S; Bonnet, S; Simon, C

    2018-03-01

    Accelerometry is increasingly used to quantify physical activity (PA) and related energy expenditure (EE). Linear regression models designed to derive PAEE from accelerometry-counts have shown their limits, mostly due to the lack of consideration of the nature of activities performed. Here we tested whether a model coupling an automatic activity/posture recognition (AAR) algorithm with an activity-specific count-based model, developed in 61 subjects in laboratory conditions, improved PAEE and total EE (TEE) predictions from a hip-worn triaxial-accelerometer (ActigraphGT3X+) in free-living conditions. Data from two independent subject groups of varying body mass index and age were considered: 20 subjects engaged in a 3-h urban-circuit, with activity-by-activity reference PAEE from combined heart-rate and accelerometry monitoring (Actiheart); and 56 subjects involved in a 14-day trial, with PAEE and TEE measured using the doubly-labeled water method. PAEE was estimated from accelerometry using the activity-specific model coupled to the AAR algorithm (AAR model), a simple linear model (SLM), and equations provided by the companion-software of used activity-devices (Freedson and Actiheart models). AAR-model predictions were in closer agreement with selected references than those from other count-based models, both for PAEE during the urban-circuit (RMSE = 6.19 vs 7.90 for SLM and 9.62 kJ/min for Freedson) and for EE over the 14-day trial, reaching Actiheart performances in the latter (PAEE: RMSE = 0.93 vs. 1.53 for SLM, 1.43 for Freedson, 0.91 MJ/day for Actiheart; TEE: RMSE = 1.05 vs. 1.57 for SLM, 1.70 for Freedson, 0.95 MJ/day for Actiheart). Overall, the AAR model resulted in a 43% increase of daily PAEE variance explained by accelerometry predictions. NEW & NOTEWORTHY Although triaxial accelerometry is widely used in free-living conditions to assess the impact of physical activity energy expenditure (PAEE) on health, its precision and accuracy are often debated

  5. 75 FR 38135 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    .... Chemicals, Inc.. 73,538 JT Sports, LLC, Neosho, MO February 12, 2009. Leased Workers of Kelly Services and Manpower. 73,538A JT Sports, LLC, Bentonville, AR..... February 12, 2009. Corporate Headquarters. 73,552... Services. 73,993 Springer Norwell, MA......... April 22, 2009. Science+Business Media, LLC. 73,993A Health...

  6. Body-wide anatomy recognition in PET/CT images

    NASA Astrophysics Data System (ADS)

    Wang, Huiqian; Udupa, Jayaram K.; Odhner, Dewey; Tong, Yubing; Zhao, Liming; Torigian, Drew A.

    2015-03-01

    With the rapid growth of positron emission tomography/computed tomography (PET/CT)-based medical applications, body-wide anatomy recognition on whole-body PET/CT images becomes crucial for quantifying body-wide disease burden. This, however, is a challenging problem and seldom studied due to unclear anatomy reference frame and low spatial resolution of PET images as well as low contrast and spatial resolution of the associated low-dose CT images. We previously developed an automatic anatomy recognition (AAR) system [15] whose applicability was demonstrated on diagnostic computed tomography (CT) and magnetic resonance (MR) images in different body regions on 35 objects. The aim of the present work is to investigate strategies for adapting the previous AAR system to low-dose CT and PET images toward automated body-wide disease quantification. Our adaptation of the previous AAR methodology to PET/CT images in this paper focuses on 16 objects in three body regions - thorax, abdomen, and pelvis - and consists of the following steps: collecting whole-body PET/CT images from existing patient image databases, delineating all objects in these images, modifying the previous hierarchical models built from diagnostic CT images to account for differences in appearance in low-dose CT and PET images, automatically locating objects in these images following object hierarchy, and evaluating performance. Our preliminary evaluations indicate that the performance of the AAR approach on low-dose CT images achieves object localization accuracy within about 2 voxels, which is comparable to the accuracies achieved on diagnostic contrast-enhanced CT images. Object recognition on low-dose CT images from PET/CT examinations without requiring diagnostic contrast-enhanced CT seems feasible.

  7. Both alpha(1A)- and alpha(1B)-adrenergic receptors crosstalk to down regulate beta(1)-ARs in mouse heart: coupling to differential PTX-sensitive pathways.

    PubMed

    Rorabaugh, Boyd R; Gaivin, Robert J; Papay, Robert S; Shi, Ting; Simpson, Paul C; Perez, Dianne M

    2005-11-01

    Adrenergic receptors (ARs) play an important role in the regulation of cardiac function. Cardiac inotropy is primarily regulated by beta(1)-ARs. However, alpha(1)-ARs may play an important role in inotropy during heart failure. Previous work has suggested that the alpha(1B)-AR modulates beta(1)-AR function in the heart. The potential role of the alpha(1A)-AR has not been previously studied. We used transgenic mice that express constitutively active mutant (CAM) forms of the alpha(1A)-AR or alpha(1B)-AR regulated by their endogenous promoters. Expression of the CAM alpha(1A)-AR or CAM alpha(1B)-AR had no effect on basal cardiac function (developed pressure, +dP/dT, -dP/dT, heart rate, flow rate). However, both alpha(1)-AR subtypes significantly decreased isoproterenol-stimulated +dP/dT. Pertussis toxin had no effect on +dP/dT in CAM alpha(1A)-AR hearts but restored +dP/dT to non-transgenic values in CAM alpha(1B)-AR hearts. Radioligand binding indicated a selective decrease in the density of beta(1)-ARs in both CAM mice. However, G-proteins, cAMP, or the percentage of high and low affinity states were unchanged in either transgenic compared with control. These data demonstrate that CAM alpha(1A)- and alpha(1B)-ARs both down regulate beta(1)-AR-mediated inotropy in the mouse heart. However, alpha(1)-AR subtypes are coupled to different beta-AR mediated signaling pathways with the alpha(1B)-AR being pertussis toxin sensitive.

  8. Mantle structure beneath Africa and Arabia from adaptively parameterized P-wave tomography: Implications for the origin of Cenozoic Afro-Arabian tectonism

    NASA Astrophysics Data System (ADS)

    Hansen, Samantha E.; Nyblade, Andrew A.; Benoit, Margaret H.

    2012-02-01

    While the Cenozoic Afro-Arabian Rift System (AARS) has been the focus of numerous studies, it has long been questioned if low-velocity anomalies in the upper mantle beneath eastern Africa and western Arabia are connected, forming one large anomaly, and if any parts of the anomalous upper mantle structure extend into the lower mantle. To address these questions, we have developed a new image of P-wave velocity variations in the Afro-Arabian mantle using an adaptively parameterized tomography approach and an expanded dataset containing travel-times from earthquakes recorded on many new temporary and permanent seismic networks. Our model shows a laterally continuous, low-velocity region in the upper mantle beneath all of eastern Africa and western Arabia, extending to depths of ~ 500-700 km, as well as a lower mantle anomaly beneath southern Africa that rises from the core-mantle boundary to at least ~ 1100 km depth and possibly connects to the upper mantle anomaly across the transition zone. Geodynamic models which invoke one or more discrete plumes to explain the origin of the AARS are difficult to reconcile with the lateral and depth extent of the upper mantle low-velocity region, as are non-plume models invoking small-scale convection passively induced by lithospheric extension or by edge-flow around thick cratonic lithosphere. Instead, the low-velocity anomaly beneath the AARS can be explained by the African superplume model, where the anomalous upper mantle structure is a continuation of a large, thermo-chemical upwelling in the lower mantle beneath southern Africa. These findings provide further support for a geodynamic connection between processes in Earth's lower mantle and continental break-up within the AARS.

  9. Orientation-dependent potential of mean force for protein folding

    NASA Astrophysics Data System (ADS)

    Mukherjee, Arnab; Bhimalapuram, Prabhakar; Bagchi, Biman

    2005-07-01

    We present a solvent-implicit minimalistic model potential among the amino acid residues of proteins, obtained by using the known native structures [deposited in the Protein Data Bank (PDB)]. In this model, the amino acid side chains are represented by a single ellipsoidal site, defined by the group of atoms about the center of mass of the side chain. These ellipsoidal sites interact with other sites through an orientation-dependent interaction potential which we construct in the following fashion. First, the site-site potential of mean force (PMF) between heavy atoms is calculated [following F. Melo and E. Feytsman, J. Mol. Biol. 267, 207 (1997)] from statistics of their distance separation obtained from crystal structures. These site-site potentials are then used to calculate the distance and the orientation-dependent potential between side chains of all the amino acid residues (AAR). The distance and orientation dependencies show several interesting results. For example, we find that the PMF between two hydrophobic AARs, such as phenylalanine, is strongly attractive at short distances (after the obvious repulsive region at very short separation) and is characterized by a deep minimum, for specific orientations. For the interaction between two hydrophilic AARs, such a deep minimum is absent and in addition, the potential interestingly reveals the combined effect of polar (charge) and hydrophobic interactions among some of these AARs. The effectiveness of our potential has been tested by calculating the Z-scores for a large set of proteins. The calculated Z-scores show high negative values for most of them, signifying the success of the potential to identify the native structure from among a large number of its decoy states.

  10. Amino acid starvation sensing dampens IL-1β production by activating riboclustering and autophagy

    PubMed Central

    Battu, Srikanth; Afroz, Sumbul; Giddaluru, Jeevan; Naz, Saima; Huang, Weishan; Khumukcham, Saratchandra Singh; Khan, Rafiq Ahmad; Bhat, Saleem Yousuf; Qureshi, Insaf Ahmed; Manavathi, Bramanandam; Khan, Aleem Ahmed; August, Avery; Hasnain, Seyed Ehtesham; Khan, Nooruddin

    2018-01-01

    Activation of the amino acid starvation response (AAR) increases lifespan and acute stress resistance as well as regulates inflammation. However, the underlying mechanisms remain unclear. Here, we show that activation of AAR pharmacologically by Halofuginone (HF) significantly inhibits production of the proinflammatory cytokine interleukin 1β (IL-1β) and provides protection from intestinal inflammation in mice. HF inhibits IL-1β through general control nonderepressible 2 kinase (GCN2)–dependent activation of the cytoprotective integrated stress response (ISR) pathway, resulting in rerouting of IL-1β mRNA from translationally active polysomes to inactive ribocluster complexes—such as stress granules (SGs)—via recruitment of RNA-binding proteins (RBPs) T cell–restricted intracellular antigen-1(TIA-1)/TIA-1–related (TIAR), which are further cleared through induction of autophagy. GCN2 ablation resulted in reduced autophagy and SG formation, which is inversely correlated with IL-1β production. Furthermore, HF diminishes inflammasome activation through suppression of reactive oxygen species (ROS) production. Our study unveils a novel mechanism by which IL-1β is regulated by AAR and further suggests that administration of HF might offer an effective therapeutic intervention against inflammatory diseases. PMID:29621237

  11. Alanyl-tRNA synthetase mutation in a family with dominant distal hereditary motor neuropathy

    PubMed Central

    Zhao, Z.; Hashiguchi, A.; Sakiyama, Y.; Okamoto, Y.; Tokunaga, S.; Zhu, L.; Shen, H.; Takashima, H.

    2012-01-01

    Objective: To identify a new genetic cause of distal hereditary motor neuropathy (dHMN), which is also known as a variant of Charcot-Marie-Tooth disease (CMT), in a Chinese family. Methods: We investigated a Chinese family with dHMN clinically, electrophysiologically, and genetically. We screened for the mutations of 28 CMT or related pathogenic genes using an originally designed microarray resequencing DNA chip. Results: Investigation of the family history revealed an autosomal dominant transmission pattern. The clinical features of the family included mild weakness and wasting of the distal muscles of the lower limb and foot deformity, without clinical sensory involvement. Electrophysiologic studies revealed motor neuropathy. MRI of the lower limbs showed accentuated fatty infiltration of the gastrocnemius and vastus lateralis muscles. All 4 affected family members had a heterozygous missense mutation c.2677G>A (p.D893N) of alanyl-tRNA synthetase (AARS), which was not found in the 4 unaffected members and control subjects. Conclusion: An AARS mutation caused dHMN in a Chinese family. AARS mutations result in not only a CMT phenotype but also a dHMN phenotype. PMID:22573628

  12. Atlantoaxial Rotatory Subluxation: A Review for the Pediatric Emergency Physician.

    PubMed

    Kinon, Merritt D; Nasser, Rani; Nakhla, Jonathan; Desai, Rupen; Moreno, Jessica R; Yassari, Reza; Bagley, Carlos A

    2016-10-01

    Pediatric emergency physicians must have a high clinical suspicion for atlantoaxial rotatory subluxation (AARS), particularly when a child presents with neck pain and an abnormal head posture without the ability to return to a neutral position. As shown in the neurosurgical literature, timely diagnosis and swift initiation of treatment have a greater chance of treatment success for the patient. However, timely treatment is complicated because torticollis can result from a variety of maladies, including: congenital abnormalities involving the C1-C2 joint or the surrounding supporting muscles and ligaments, central nervous system abnormalities, obstetric palsies from brachial plexus injuries, clavicle fractures, head and neck surgery, and infection. The treating pediatrician must discern the etiology of the underlying problem to determine both timing and treatment paradigms, which vary widely between these illnesses. We present a comprehensive review of AARS that is intended for pediatric emergency physicians. Management of AARS can vary widely bases on factors, such as duration of symptoms, as well as the patient's history. The goal of this review is to streamline the management paradigms and provide an inclusive review for pediatric emergency first responders.

  13. All-cancers mortality rates approaching diseases of the heart mortality rates as leading cause of death in Texas.

    PubMed

    Wyatt, Stephen W; Maynard, William Ryan; Risser, David R; Hakenewerth, Anne M; Williams, Melanie A; Garcia, Rebecca

    2014-01-01

    Diseases of the heart and malignant neoplasms (all-cancers) are the leading causes of death in the United States. The gap between the two has been closing in recent years. To assess the gap status in Texas and to establish a baseline to support evaluation efforts for the Cancer Prevention Research Institute of Texas, mortality data from 2006 to 2009 were analyzed. Immediate cause of death data in Texas for the years 2006-2009 were analyzed and rates developed by sex, race/ethnicity, and four metropolitan counties. Overall, for the years 2006-2009, the age-adjusted mortality rates (AARs) among Texas residents for both diseases of the heart and all-cancers decreased; however, during this time frame, there was greater improvement in diseases of the heart AARs as compared with all-cancers AARs. For the four large metropolitan counties of Bexar, Dallas, Harris, and Travis, data were analyzed by sex and race/ethnicity, and 11 of the 12 largest percent mortality rate decreases were for diseases of the heart. Age-adjusted mortality rates among Texas residents from diseases of the heart are showing improvement as compared with the rates for all-cancers.

  14. Structural basis of Brr2-Prp8 interactions and implications for U5 snRNP biogenesis and the spliceosome active site.

    PubMed

    Nguyen, Thi Hoang Duong; Li, Jade; Galej, Wojciech P; Oshikane, Hiroyuki; Newman, Andrew J; Nagai, Kiyoshi

    2013-06-04

    The U5 small nuclear ribonucleoprotein particle (snRNP) helicase Brr2 disrupts the U4/U6 small nuclear RNA (snRNA) duplex and allows U6 snRNA to engage in an intricate RNA network at the active center of the spliceosome. Here, we present the structure of yeast Brr2 in complex with the Jab1/MPN domain of Prp8, which stimulates Brr2 activity. Contrary to previous reports, our crystal structure and mutagenesis data show that the Jab1/MPN domain binds exclusively to the N-terminal helicase cassette. The residues in the Jab1/MPN domain, whose mutations in human Prp8 cause the degenerative eye disease retinitis pigmentosa, are found at or near the interface with Brr2, clarifying its molecular pathology. In the cytoplasm, Prp8 forms a precursor complex with U5 snRNA, seven Smproteins, Snu114, and Aar2, but after nuclear import, Brr2 replaces Aar2 to form mature U5 snRNP. Our structure explains why Aar2 and Brr2 are mutually exclusive and provides important insights into the assembly of U5 snRNP.

  15. Parallel loss of nuclear-encoded mitochondrial aminoacyl-tRNA synthetases and mtDNA-encoded tRNAs in Cnidaria.

    PubMed

    Haen, Karri M; Pett, Walker; Lavrov, Dennis V

    2010-10-01

    Unlike most animal mitochondrial (mt) genomes, which encode a set of 22 transfer RNAs (tRNAs) sufficient for mt protein synthesis, those of cnidarians have only retained one or two tRNA genes. Whether the missing cnidarian mt-tRNA genes relocated outside the main mt chromosome or were lost remains unclear. It is also unknown what impact the loss of tRNA genes had on other components of the mt translational machinery. Here, we explored the nuclear genome of the cnidarian Nematostella vectensis for the presence of mt-tRNA genes and their corresponding mt aminoacyl-tRNA synthetases (mt-aaRS). We detected no candidates for mt-tRNA genes and only two mt-aaRS orthologs. At the same time, we found that all but one cytosolic aaRS appear to be targeted to mitochondria. These results indicate that the loss of mt-tRNAs in Cnidaria is genuine and occurred in parallel with the loss of nuclear-encoded mt-aaRS. Our phylogenetic analyses of individual aaRS revealed that although the nearly total loss of mt-aaRS is rare, aaRS gene deletion and replacement have occurred throughout the evolution of Metazoa.

  16. Methylobacterium marchantiae sp. nov., a pink-pigmented, facultatively methylotrophic bacterium isolated from the thallus of a liverwort.

    PubMed

    Schauer, S; Kämpfer, P; Wellner, S; Spröer, C; Kutschera, U

    2011-04-01

    A pink-pigmented, facultatively methylotrophic bacterium, designated strain JT1(T), was isolated from a thallus of the liverwort Marchantia polymorpha L. and was analysed by using a polyphasic approach. Comparative 16S rRNA gene sequence analysis placed the strain in a clade with Methylobacterium adhaesivum AR27(T), Methylobacterium fujisawaense DSM 5686(T), Methylobacterium radiotolerans JCM 2831(T) and Methylobacterium jeotgali S2R03-9(T), with which it showed sequence similarities of 97.8, 97.7, 97.2 and 97.4 %, respectively. However, levels of DNA-DNA relatedness between strain JT1(T) and these and the type strains of other closely related species were lower than 70 %. Cells of JT1(T) stained Gram-negative and were motile, rod-shaped and characterized by numerous fimbriae-like appendages on the outer surface of their wall (density up to 200 µm(-2)). Major fatty acids were C(18 : 1)ω7c and C(16 : 0). Based on the morphological, physiological and biochemical data presented, strain JT1(T) is considered to represent a novel species of the genus Methylobacterium, for which the name Methylobacterium marchantiae sp. nov. is proposed. The type strain is JT1(T) ( = DSM 21328(T)  = CCUG 56108(T)).

  17. Integrated Battlefield Effects Research for the National Training Center. Appendix E. Requirements Design Specification and Demonstration Report for the Exercise Coordination and Control (ECC) Demonstration System

    DTIC Science & Technology

    1984-12-31

    mode 3. Edit AAR mode 4. Run AR mode Each of the modes shall be mutually eclusive. In the real-time mode, the station tactical display shall reflect...periods of the exercise segment. The edit AAR mode shall provide the operator with the capability of creating/ editing a command file for use during an...II .,II IH 0 - hUi I -24 .6d, -I" @ 0 M% A A a a dJ a) 6 I I - -- a’ 1.* % 46- 8 ’ 0 "S 8 -- -- "- - I .-36 aISa "S-a:z:-a I I b 0 Il -- I -- I1 -I

  18. Development and Implementation of High Bandwidth Pulsed Microactuators for Sub and Supersonic Applications

    DTIC Science & Technology

    2012-06-15

    Microactuators of High –Speed Flow Control”, AIAA- 2938 , 2011. 12. Kreth, P., Solomon, J.T., Alvi, F.S., “Resonance-Enhanced High Frequency Micro...paper 2938 , 2011. 34. Ali, M.Y., Solomon, J.T., Gustavsson, J., Kumar, R., Alvi, F.S., “Control of Supersonic Cavity Flows Using High Bandwidth Micro

  19. Differences in volatile profiles between populations of Ceratoides lanata var. subspinosa (Rydb.)

    Treesearch

    J.T. Howell; Mary Lucero; Rick Estell; Dean Anderson; Ed Fredrickson; Marta Remmenga

    2007-01-01

    Ceratoides lanata (Rydb.) J.T. Howell, common winterfat, is valued for its nutrient content and palatability to livestock; however, the subspecies Ceratoides lanata var. subspinosa (Rydb.) J.T. Howell, (‘subspinosa’) is considered unpalatable. Curiously, observations of ‘subspinosa’ revealed several populations...

  20. Comparison of trapezius squeeze test and jaw thrust as clinical indicators for laryngeal mask airway insertion in spontaneously breathing children

    PubMed Central

    Dinesh Kumar, K. K.; Bhardwaj, Neerja; Yaddanapudi, Sandhya

    2017-01-01

    Background and Aims: It is not known whether trapezius squeeze test (TPZ) is a better clinical test than jaw thrust (JT) to assess laryngeal mask airway (LMA) insertion conditions in children under sevoflurane anesthesia. Material and Methods: After the Institutional Ethics Committee approval and written informed parental consent, 124 American Society of Anesthesiologists I and II children of 2–8 years of age undergoing minor surgical procedures were randomized into TPZ and JT groups. The children were induced with 8% sevoflurane in oxygen at a fresh gas flow of 4 L/min. TPZ or JT was performed after 1 min of start of sevoflurane and then every 20 s till the test was negative, when end-tidal (ET) sevoflurane concentration was noted. Classic LMA of requisite size was inserted by a blinded anesthetist and conditions at the insertion of LMA, insertion time, and the number of attempts of LMA insertion were recorded. Results: The mean LMA insertion time was significantly longer (P < 0.001) for TPZ (145 ± 28.7 sec) compared to JT group (111.8 ± 31.0 sec). ET sevoflurane concentration at the time of LMA insertion was comparable in the two groups. LMA insertion conditions were similar in the two groups. There was no difference between the two groups regarding total number of attempts of LMA insertion. Heart rate (HR) decreased in both groups after LMA insertion (P < 0.001) but TPZ group had significantly lower HR compared with the JT group up to 5 min after LMA insertion (P = 0.03). Conclusion: Both JT and TPZ are equivalent clinical indicators in predicting the optimal conditions of LMA insertion in spontaneously breathing children; however, it takes a longer time to achieve a negative TPZ squeeze test. PMID:28413275

  1. Environmentally Compliant Vinyl Ester Resin (VER) Composite Matrix Resin Derived from Renewable Resources

    DTIC Science & Technology

    2011-11-01

    Carbon Fiber Production– 02FCC-144”; C.F. Leit- ten, Jr., W.L. Griffith, A.L. Compere , and J.T. Shaffer, Society of Automotive Engineers, Inc., 2001. 8...Cost Carbon Fiber from Renewable Resources”; A.L. Compere , W.L. Griffith, C.F. Leitten, Jr., and J.T. Shaffer, Oak Ridge National Laboratory Report

  2. Some Hardware and Instrumentation Aspects of the Development of an Automation System for Jar Tests in Drinking Water Treatment

    PubMed Central

    2017-01-01

    The so-called Jar Test (JT) plays a vital role in the drinking water and wastewater treatments for establishing the dosage of flocculants and coagulant. This test is a well-proved laboratory instrumental procedure performed by trained personnel. In this work, a completely novel system for the automation and monitoring of a JT devoted to drinking water treatment is presented. It has been implemented using an industrial programmable controller and sensors and instruments specifically selected for this purpose. Once the parameters of the test have been entered, the stages that compose the JT (stirring, coagulant addition, etc.) are sequentially performed without human intervention. Moreover, all the involved measurements from sensors are collected and made accessible for continuous monitoring of the process. By means of the proposed system, the JT procedure is conducted fully automatically and can be locally and remotely monitored in real-time. Furthermore, the developed system constitutes a portable laboratory that offers advantageous features like scalability and transportability. The proposed system is described focusing on hardware and instrumentation aspects, and successful results are reported. PMID:29019943

  3. Some Hardware and Instrumentation Aspects of the Development of an Automation System for Jar Tests in Drinking Water Treatment.

    PubMed

    Calderón, Antonio José; González, Isaías

    2017-10-11

    The so-called Jar Test (JT) plays a vital role in the drinking water and wastewater treatments for establishing the dosage of flocculants and coagulant. This test is a well-proved laboratory instrumental procedure performed by trained personnel. In this work, a completely novel system for the automation and monitoring of a JT devoted to drinking water treatment is presented. It has been implemented using an industrial programmable controller and sensors and instruments specifically selected for this purpose. Once the parameters of the test have been entered, the stages that compose the JT (stirring, coagulant addition, etc.) are sequentially performed without human intervention. Moreover, all the involved measurements from sensors are collected and made accessible for continuous monitoring of the process. By means of the proposed system, the JT procedure is conducted fully automatically and can be locally and remotely monitored in real-time. Furthermore, the developed system constitutes a portable laboratory that offers advantageous features like scalability and transportability. The proposed system is described focusing on hardware and instrumentation aspects, and successful results are reported.

  4. Potential improvements in turbofan engine fuel economy

    NASA Technical Reports Server (NTRS)

    Hines, R. W.; Gaffin, W. O.

    1976-01-01

    The method developed for initial evaluation of possible performance improvements in the NASA Aircraft Energy Efficiency Program, directed toward improving the fuel economy of turbofan engines, is outlined, and results of the evaluation of 100 candidate engine modifications are presented. The study indicates that fuel consumption improvements of as much as 5% may be possible in current JT3D, JT8D, and JT9D turbofan engines. Aerodynamic, thermodynamic, material, and structural advances are expected to yield fuel consumption improvements on the order of 10 to 15% in advanced turbofan engines, with the greatest improvement stemming from significantly higher cycle pressure ratios. Higher turbine temperature and fan bypass ratios are also expected to contribute to fuel conservation.

  5. Hyperparathyroidism-jaw tumour syndrome detected by aggressive generalized osteitis fibrosa cystica.

    PubMed

    Guerrouani, Alae; Rzin, Abdelkader; El Khatib, Karim

    2013-01-01

    Severe hyperparathyroidism can affect bone metabolism and be in the origine of multiple brown tumours (generalized osteitis fibrosa cystica). When associated with fibro-ossifying tumours of the jaw, it realizes a rare genetic syndrome referred as Hyperparathyroidism-jaw tumour HPT-JT. We report the case of a patient we treated for HPT-JT, and literature review.

  6. Tidal Channel Dynamics and Muddy Substrates: a Comparison Between a Wave Dominated and a Tidal Dominated System

    DTIC Science & Technology

    2011-09-30

    McGlathery, J.T. Morris, T.J. Tolhurst, L.A. Deegan , D.S. Johnson, Ecogeomorphology of Salt Marshes (in press) Fagherazzi S., D.M. FitzGerald, R.W...Fulweiler, Z. Hughes, P.L. Wiberg, K.J. McGlathery, J.T. Morris, T.J. Tolhurst, L.A. Deegan , D.S. Johnson, Ecogeomorphology of Tidal Flats (in press

  7. Recent RF Experiments and Application of RF Waves to Real-Time Control of Safety Factor Profile in JT-60U

    NASA Astrophysics Data System (ADS)

    Suzuki, T.; Isayama, A.; Ide, S.; Fujita, T.; Oikawa, T.; Sakata, S.; Sueoka, M.; Hosoyama, H.; JT-60 Team

    2005-09-01

    Two topics of applications of RF waves to current profile control in JT-60U are presented; application of lower-hybrid (LH) waves to safety factor profile control and electron cyclotron (EC) waves to neo-classical tearing mode (NTM) control. A real-time control system of safety factor (q) profile was developed. This system, for the first time, enables 1) real time evaluation of q profile using local magnetic pitch angle measurement by motional Stark effect (MSE) diagnostic and 2) control of current drive (CD) location (ρCD) by controlling the parallel refractive index N∥ of LH waves through control of phase difference (Δφ) of LH waves between multi-junction launcher modules. The method for real-time q profile evaluation was newly developed, without time-consuming reconstruction of equilibrium, so that the method requires less computational time. Safety factor profile by the real-time calculation agrees well with that by equilibrium reconstruction with MSE. The control system controls ρCD through Δφ in such a way to decrease the largest residual between the real-time evaluated q profile q(r) and its reference profile qref(r). The real-time control system was applied to a positive shear plasma (q(0)˜1). The reference q profile was set to monotonic positive shear profile having qref(0)=1.3. The real-time q profile approached to the qref(r) during application of real-time control, and was sustained for 3s, which was limited by the duration of the injected LH power. Temporal evolution of current profile was consistent with relaxation of inductive electric field induced by theoretical LH driven current. An m/n=3/2 NTM that appeared at βN˜3 was completely stabilized by ECCD applied to a fully-developed NTM. Precise ECCD at NTM island was essential for the stabilization. ECCD that was applied to resonant rational surface (q=3/2) before an NTM onset suppressed appearance of NTM. In order to keep NTM intensity below a level, ECCD before the mode onset was more

  8. High-Resolution Laser Spectroscopy of Free Radicals in Nearly Degenerate Electronic States

    NASA Astrophysics Data System (ADS)

    Liu, Jinjun

    2017-06-01

    Rovibronic structure of molecules in orbitally degenerate electronic states including Renner-Teller (RT) and Jahn-Teller (JT) active molecules has been extensively studied. Less is known about rotational structure of polyatomic molecules in nearly degenerate states, especially those with low (e.g., C_s) symmetry that are subject to the pseudo-Jahn-Teller (pJT) effect. In the case of free radicals, the unpaired electron further complicates energy levels by inducing spin-orbit (SO) and spin-rotation (SR) splittings. Asymmetric deuteration or methyl substitution of C_{3v} free radicals such as CH_3O, CaCH_3, and CaOCH_3 lowers the molecular symmetry, lifts the vibronic degeneracy, and reduces the JT effect to the pJT effect. New spectroscopic models are required to reproduce the rovibronic structure and simulate the experimentally obtained spectra of pJT-active free radicals. It has been found that rotational and fine-structure analysis of spectra involving nearly degenerate states may aid in vibronic analysis and interpretation of effective molecular constants. Especially, SO and Coriolis interactions that couple the two states can be determined accurately from fitting the experimental spectra. Coupling between the two electronic states also affects the intensities of rotational and vibronic transitions. The study on free radicals in nearly degenerate states provides a promising avenue of research which may bridge the gap between symmetry-induced degenerate states and the Born-Oppenheimer (BO) limit of unperturbed electronic states.

  9. Salivary alpha amylase in on-call from home fire and emergency service personnel.

    PubMed

    Hall, Sarah J; Aisbett, Brad; Robertson, Samuel J; Ferguson, Sally A; Turner, Anne I

    2017-11-01

    The effect of working on-call from home on the sympatho-adrenal medullary system activity is currently unknown. This study had two aims, Aim 1: examine salivary alpha amylase awakening response (AAR) and diurnal salivary alpha amylase (sAA) profile in fire and emergency service workers who operate on-call from home following a night on-call with a call (NIGHT-CALL), a night on-call without a call (NO-CALL) and an off-call night (OFF-CALL), and Aim 2: explore whether there was an anticipatory effect of working on-call from home (ON) compared to when there was an off-call (OFF) on the diurnal sAA profile. Participants wore activity monitors, completed sleep and work diaries and collected seven saliva samples a day for one week. AAR area under the curve with respect to ground (AUC G ), AAR area under the curve with respect to increase (AUC I ), AAR reactivity, diurnal sAA slope, diurnal sAA AUC G and mean 12-h sAA concentrations were calculated. Separate generalised estimating equation models were constructed for each variable of interest for each aim. For Aim 1, there were no differences between NIGHT-CALL or NO-CALL and OFF-CALL for any response variable. For Aim 2, there was no difference between any response variable of interest when ON the following night compared to when OFF the following night ( n  = 14). These findings suggest that there is no effect of working on-call from home on sAA, but should be interpreted with caution, as overnight data were not collected. Future research, using overnight heart rate monitoring, could help confirm these findings. © 2017 The authors.

  10. Boundary condition for toroidal plasma flow imposed at the separatrix in high confinement JT-60U plasmas with edge localized modes and the physics process in pedestal structure formation

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kamiya, K.; Honda, M.; Urano, H.

    2014-12-15

    Modulation charge eXchange recombination spectroscopy measurements with high spatial and temporal resolution have made the evaluation of the toroidal plasma flow of fully stripped carbon impurity ions (V{sub ϕ}{sup C6+}) in the JT-60U tokamak peripheral region (including, in particular, the separatrix) possible with a better signal-to-noise ratio. By comparing co- and counter-neutral beam injection discharges experimentally, we have identified the boundary condition of V{sub ϕ}{sup C6+} and radial electric field shear (∇E{sub r}) imposed at the separatrix in high confinement (H-mode) plasmas with edge localized modes (ELMs). The V{sub ϕ}{sup C6+} value at the separatrix is not fixed at zeromore » but varies with the momentum input direction. On the other hand, the ∇E{sub r} value is nearly zero (or very weakly positive) at the separatrix. Furthermore, the edge localized mode perturbation does not appear to affect both V{sub ϕ}{sup C6+} and ∇E{sub r} values at the separatrix as strongly as that in the pedestal region. The above experimental findings based on the precise edge measurements have been used to validate a theoretical model and develop a new empirical model. A better understanding of the physical process in the edge transport barrier (ETB) formation due to the sheared E{sub r} formation is also discussed.« less

  11. U.S. EPA, Pesticide Product Label, INDUCLOR, 03/12/1984

    EPA Pesticide Factsheets

    2011-04-14

    ... dlrt<...tt1 i ;\\h:_f~P tJf'i".! fr, " 1.,1 1,'! rh!CHlnf' r'·3l(ju·\\1 u~ :;t '., j~;t fl.' [,P!' and no IT'nrp t flJt Hlf' d!~~!·I"'Il·' I;! "Y:'~"/Il ...

  12. Rocketdyne RBCC Engine Concept Development

    NASA Technical Reports Server (NTRS)

    Ratckin, G.; Goldman, A.; Ortwerth, P.; Weisberg, S.

    1999-01-01

    Boeing Rocketdyne is pursuing the development of Rocket Based Combined Cycle (RBCC), propulsion systems as demonstrated by significant contract work in the hypersonic arena (ART, NASP, SCT, system studies) and over 12 years of steady company discretionary investment. The Rocketdyne concept is a fixed geometry integrated rocket, ramjet, scramjet which is hydrogen fueled and uses hydrogen regenerative cooling. The baseline engine structural configuration uses an integral structure that eliminates panel seals. seal purge gas, and closeout side attachments. Rocketdyne's experimental RBCC engine (Engine A5) was constructed under contract with the NASA Marshall Space Flight Center. Engine A5 models the complete flight engine flowpath consisting of an inlet, isolator, airbreathing combustor and nozzle. High performance rocket thrusters are integrated into the engine to enable both air-augmented rocket (AAR) and pure rocket operation. Engine A5 was tested in CASL's new FAST facility as an air-augmented rocket, a ramjet and a pure rocket. Measured performance demonstrated vision vehicle performance levels for Mach 3 AAR operation and ramjet operation from Mach 3 to 4. Rocket mode performance was above predictions. For the first time. testing also demonstrated transition from AAR operation to ramjet operation. This baseline configuration has also been shown, in previous testing, to perform well in the scramjet mode.

  13. The DarkSide physics program and its recent results

    DOE PAGES

    D'Angelo, D.

    2017-01-12

    Here, DarkSide (DS) at Gran Sasso underground laboratory is a direct Dark Matter search program based on Time Projection Chambers (TPC) with liquid Argon from underground sources. The DarkSide-50 (DS-50) TPC, with 150 kg of Argon is installed inside active neutron and muon detectors. DS-50 has been taking data since November 2013 with Atmospheric Argon (AAr) and since April 2015 with Underground Argon (UAr), depleted in radioactive 39Ar by a factor ~1400. The exposure of 1422 kg d of AAr has demonstrated that the operation of DS-50 for three years in a background free condition is a solid reality, thanksmore » to the superb performance of the Pulse Shape Analysis. The first release of results from an exposure of 2616 kg d of UAr has shown no candidate Dark Matter events. We have set the best limit for Spin-Independent elastic nuclear scattering of WIMPs obtained by Argon-based detectors, corresponding to a cross-section of 2 10 –44 cm 2 at a WIMP mass of 100 GeV. We present the detector design and performance, the results from the AAr run and the first results from the UAr run and we briefly introduce the future of the DarkSide program.« less

  14. The DarkSide physics program and its recent results

    NASA Astrophysics Data System (ADS)

    D'Angelo, D.; Agnes, P.; Agostino, L.; F. M. Albuquerque, I.; Alexander, T.; K. Alton, A.; Arisaka, K.; Back, H. O.; Baldin, B.; Biery, K.; Bonfini, G.; Bossa, M.; Bottino, B.; Brigatti, A.; Brodsky, J.; Budano, F.; Bussino, S.; Cadeddu, M.; Cadonati, L.; Cadoni, M.; Calaprice, F.; Canci, N.; Candela, A.; Cao, H.; Cariello, M.; Carlini, M.; Catalanotti, S.; Cavalcante, P.; Chepurnov, A.; Cocco, A. G.; Covone, G.; Crippa, L.; D'Incecco, M.; Davini, S.; De Cecco, S.; De Deo, M.; De Vincenzi, M.; Derbin, A.; Devoto, A.; Di Eusanio, F.; Di Pietro, G.; Edkins, E.; Empl, A.; Fan, A.; Fiorillo, G.; Fomenko, K.; Forster, G.; Franco, D.; Gabriele, F.; Galbiati, C.; Giganti, C.; M. Goretti, A.; Granato, F.; Grandi, L.; Gromov, M.; Guan, M.; Guardincerri, Y.; R. Hackett, B.; Herner, K.; V. Hungerford, E.; Ianni, Al.; Ianni, An.; James, I.; Jollet, C.; Keeter, K.; L. Kendziora, C.; Kobychev, V.; Koh, G.; Korablev, D.; Korga, G.; Kubankin, A.; Lissia, M.; Li, X.; Lombardi, P.; Luitz, S.; N. Machulin, I.; Mandarano, A.; Maricic, J.; Marini, L.; M. Mari, S.; J. Martoff, C.; Ma, Y.; Meregaglia, A.; D. Meyers, P.; Miletic, T.; Milincic, R.; Montanari, D.; Monte, A.; Montuschi, M.; Monzani, M.; Mosteiro, P.; J. Mount, B.; N. Muratova, V.; Musico, P.; Napolitano, J.; Nelson, A.; Odrowski, S.; Orsini, M.; Ortica, F.; Pagani, L.; Pallavicini, M.; Pantic, E.; Parmeggiano, S.; Pelczar, K.; Pelliccia, N.; Perasso, S.; Pocar, A.; Pordes, S.; A. Pugachev, D.; Qian, H.; Randle, K.; Ranucci, G.; Razeto, A.; Reinhold, B.; L. Renshaw, A.; Romani, A.; Rossi, B.; Rossi, N.; Rountree, D.; Sablone, D.; Saggese, P.; Saldanha, R.; Sands, W.; Sangiorgio, S.; Savarese, C.; Segreto, E.; A. Semenov, D.; Shields, E.; N. Singh, P.; D. Skorokhvatov, M.; Smirnov, O.; Sotnikov, A.; Stanford, C.; Suvorov, Y.; Tartaglia, R.; Tatarowicz, J.; Testera, G.; Tonazzo, A.; Trinchese, P.; V. Unzhakov, E.; Vishneva, A.; Vogelaar, B.; Wada, M.; Walker, S.; Wang, H.; Wang, Y.; W. Watson, A.; Westerdale, S.; Wilhelmi, J.; M. Wojcik, M.; Xiang, X.; Xu, J.; Yang, C.; Yoo, J.; Zavatarelli, S.; Zec, A.; Zhong, W.; Zhu, C.; Zuzel, G.

    2017-07-01

    DarkSide (DS) at Gran Sasso underground laboratory is a direct Dark Matter search program based on Time Projection Chambers (TPC) with liquid Argon from underground sources. The DarkSide-50 (DS-50) TPC, with 150kg of Argon is installed inside active neutron and muon detectors. DS-50 has been taking data since November 2013 with Atmospheric Argon (AAr) and since April 2015 with Underground Argon (UAr), depleted in radioactive ^{39} Ar by a factor {˜}1400 . The exposure of 1422kg d of AAr has demonstrated that the operation of DS-50 for three years in a background free condition is a solid reality, thanks to the superb performance of the Pulse Shape Analysis. The first release of results from an exposure of 2616kg d of UAr has shown no candidate Dark Matter events. We have set the best limit for Spin-Independent elastic nuclear scattering of WIMPs obtained by Argon-based detectors, corresponding to a cross-section of 2 10^{-44}{ cm2} at a WIMP mass of 100GeV. We present the detector design and performance, the results from the AAr run and the first results from the UAr run and we briefly introduce the future of the DarkSide program.

  15. Age estimation based on aspartic acid racemization in human sclera.

    PubMed

    Klumb, Karolin; Matzenauer, Christian; Reckert, Alexandra; Lehmann, Klaus; Ritz-Timme, Stefanie

    2016-01-01

    Age estimation based on racemization of aspartic acid residues (AAR) in permanent proteins has been established in forensic medicine for years. While dentine is the tissue of choice for this molecular method of age estimation, teeth are not always available which leads to the need to identify other suitable tissues. We examined the suitability of total tissue samples of human sclera for the estimation of age at death. Sixty-five samples of scleral tissue were analyzed. The samples were hydrolyzed and after derivatization, the extent of aspartic acid racemization was determined by gas chromatography. The degree of AAR increased with age. In samples from younger individuals, the correlation of age and D-aspartic acid content was closer than in samples from older individuals. The age-dependent racemization in total tissue samples proves that permanent or at least long-living proteins are present in scleral tissue. The correlation of AAR in human sclera and age at death is close enough to serve as basis for age estimation. However, the precision of age estimation by this method is lower than that of age estimation based on the analysis of dentine which is due to molecular inhomogeneities of total tissue samples of sclera. Nevertheless, the approach may serve as a valuable alternative or addition in exceptional cases.

  16. Relationships of physical job tasks and living conditions with occupational injuries in coal miners.

    PubMed

    Bhattacherjee, Ashis; Bertrand, Jean-Pierre; Meyer, Jean-Pierre; Benamghar, Lahoucine; Otero Sierra, Carmen; Michaely, Jean-Pierre; Ghosh, Apurna Kumar; d'Houtaud, Alphonse; Mur, Jean-Marie; Chau, Nearkasen

    2007-04-01

    This study assessed the relationships of job tasks and living conditions with occupational injuries among coal miners. The sample included randomly selected 516 underground workers. They completed a standardized self-administred questionnaire. The data were analyzed via logistic regression method. The rate of injuries in the past two years was 29.8%. The job tasks with significant crude relative risks were: power hammer, vibrating hand tools, pneumatic tools, bent trunk, awkward work posture, heat, standing about and walking, job tasks for trunk and upper/lower limbs, pain caused by work, and muscular tiredness. Logistic model shows a strong relationship between the number of job tasks (JT) and injuries (adjusted ORs vs. JT 0-1: 2.21, 95%CI 1.27-3.86 for JT 2-6 and 3.82, 2.14-6.82 for JT>or=7), and significant ORs>or=1.71 for face work, not-good-health-status, and psychotropic drug use. Musculoskeletal disorders and certain personality traits were also significant in univariate analysis. Therefore job tasks and living conditions strongly increase the injuries, and occupational physicians could help workers to find remedial measures.

  17. Cultural conditions on the production of extracellular enzymes by Trichoderma isolates from tobacco rhizosphere

    PubMed Central

    Mallikharjuna Rao, K.L.N.; Siva Raju, K.; Ravisankar, H.

    2016-01-01

    Twelve isolates of Trichoderma spp. isolated from tobacco rhizosphere were evaluated for their ability to produce chitinase and β-1,3-glucanase extracellular hydrolytic enzymes. Isolates ThJt1 and TvHt2, out of 12 isolates, produced maximum activities of chitinase and β-1,3-glucanase, respectively. In vitro production of chitinase and β-1,3-glucanase by isolates ThJt1 and TvHt2 was tested under different cultural conditions. The enzyme activities were significantly influenced by acidic pH and the optimum temperature was 30 °C. The chitin and cell walls of Sclerotium rolfsii, as carbon sources, supported the maximum and significantly higher chitinase activity by both isolates. The chitinase activity of isolate ThJt1 was suppressed significantly by fructose (80.28%), followed by glucose (77.42%), whereas the β-1,3-glucanase activity of ThJt1 and both enzymes of isolate TvHt2 were significantly suppressed by fructose, followed by sucrose. Ammonium nitrate as nitrogen source supported the maximum activity of chitinase in both isolates, whereas urea was a poor nitrogen source. Production of both enzymes by the isolates was significantly influenced by the cultural conditions. Thus, the isolates ThJt1 and TvHt2 showed higher levels of chitinase and β-1,3-glucanase activities and were capable of hydrolyzing the mycelium of S. rolfsii infecting tobacco. These organisms can be used therefore for assessment of their synergism in biomass production and biocontrol efficacy and for their field biocontrol ability against S. rolfsii and Pythium aphanidermatum infecting tobacco. PMID:26887223

  18. Episodic Upwelling of Zooplankton within a Bowhead Whale Feeding Area near Barrow, AK

    DTIC Science & Technology

    2012-09-30

    during other periods (Fig. 3). Bowhead (Balaena mysticetus) and beluga ( Delphinapterus leuca ) whales are the only Arctic endemic cetaceans that...Clarke, J.T. Correlation of a strong Alaska Coastal Current with the presence of beluga whales ( Delphinapterus leucas ) near Barrow, Alaska. Marine...Stafford, K.M., Okkonen, S.R., Clarke, J.T. Correlation of a strong Alaska Coastal Current with the presence of beluga whales ( Delphinapterus

  19. Intrinsic Local Distortions and charge carrier behavior in CMR manganites and cobaltites

    NASA Astrophysics Data System (ADS)

    Bridges, Frank

    2010-03-01

    We compare and contrast the local structure and electronic configurations in two oxide systems La1-xSrxCoO3 (LSCO) and La1-yCayMnO3 (LCMO). Although these oxides may appear quite similar they have rather different properties. At x=0, LaCoO3 (LCO) has unusual magnetic properties - diamagnetic at low T but developing a moment near 100K. The Sr doped LSCO materials show ferromagnetism for x > 0.2. For LCO, one of the possible spin state configurations called the intermediate spin (IS) state (S=1), should be Jahn-Teller (JT) active, while the low spin (S=0) and high spin (S=2) states have no JT distortion. Early local structure measurements suggested a JT distortion was present in LCO and therefore supported an IS spin model. However we find no evidence for any significant JT distortion (and hence no support for the IS model) for a range of bulk and nanoparticle cobaltites La1-xSrxCoO3, x = 0 - 0.35. In contrast there are large JT distortions in the manganites LCMO, 0.2 < x < 0.5 (Mn-O bonds), for which CMR behavior is observed. We have shown that the JT distortions in the manganites depend on both temperature T and magnetic field B, and from the B-field dependence, propose the size and nature of the polarons in LCMO. We also present Co K-edge XANES data that shown no significant shift of the edge for the cobaltites as the Sr concentration increases from x =0 to 0.35 indicating essentially no change in the electronic configuration about Co; consequently, the holes introduced via Sr doping appear to go primarily into the O bands. In contrast there is a large shift of the Mn K-edge with Ca doping indicating a change in the average Mn valence, and a corresponding change in the Mn electronic configuration. We briefly discuss some possible models.

  20. Ceramic 3D printed Joule Thomson mini cryocooler intended for HOT IR detectors

    NASA Astrophysics Data System (ADS)

    Shapiro, A.; Fraiman, L.; Parahovnik, A.

    2017-05-01

    Joule Thomson (JT) Cryocooler is a well-known technology which is widely used in research and industry. The cooling effect is achieved by isenthalpic expansion of the cooling gas in an orifice. A JT cooler has two basic components: a counter flow heat exchanger and an orifice. Due to the fact that the cooler has no moving parts and contains relatively simple components it is a great candidate for miniaturization, and realization with the new additive manufacturing technologies. In the current work we discuss the implementation of 3D ceramic printing as a possible fabrication technology for a JT cooler intended for cooling IR detectors operated at temperature of about 150K. In this paper we present a comprehensive analysis including coolant considerations, heat transfer calculations and realization of the cooler.

  1. Effect of dynamics on the elastic softening of vacancies in Si

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shirai, Koun; Ishisada, Jun

    2014-02-21

    Recently, elastic softening at temperatures below 20 K has been observed in nondoped floating zone silicon. From the experimental analysis, it has been suggested that this softening is caused by an intrinsic vacancy defect through the Jahn-Teller (JT) effect. We have theoretically studied the relations between softening and the vacancies. The ground state of the JT distortion is stiff. However, by considering atomistic dynamical and anharmonic effects, it is found that low-energy excitations exist in the E-mode distortion and that different polarizations of the E-distortion can be easily interchanged. The calculated energy barriers for the reorientation of JT distortions aremore » consistent with other experiments and calculations. This low-lying mode can be the cause of softening in the elastic responses.« less

  2. Summary of Rocketdyne Engine A5 Rocket Based Combined Cycle Testing

    NASA Technical Reports Server (NTRS)

    Ketchum. A.; Emanuel, Mark; Cramer, John

    1998-01-01

    Rocketdyne Propulsion and Power (RPP) has completed a highly successful experimental test program of an advanced rocket based combined cycle (RBCC) propulsion system. The test program was conducted as part of the Advanced Reusable Technology program directed by NASA-MSFC to demonstrate technologies for low-cost access to space. Testing was conducted in the new GASL Flight Acceleration Simulation Test (FAST) facility at sea level (Mach 0), Mach 3.0 - 4.0, and vacuum flight conditions. Significant achievements obtained during the test program include 1) demonstration of engine operation in air-augmented rocket mode (AAR), ramjet mode and rocket mode and 2) smooth transition from AAR to ramjet mode operation. Testing in the fourth mode (scramjet) is scheduled for November 1998.

  3. A 9,000-year-old caribou hunting structure beneath Lake Huron.

    PubMed

    O'Shea, John M; Lemke, Ashley K; Sonnenburg, Elizabeth P; Reynolds, Robert G; Abbott, Brian D

    2014-05-13

    Some of the most pivotal questions in human history necessitate the investigation of archaeological sites that are now under water. Nine thousand years ago, the Alpena-Amberley Ridge (AAR) beneath modern Lake Huron was a dry land corridor that connected northeast Michigan to southern Ontario. The newly discovered Drop 45 Drive Lane is the most complex hunting structure found to date beneath the Great Lakes. The site and its associated artifacts provide unprecedented insight into the social and seasonal organization of prehistoric caribou hunting. When combined with environmental and simulation studies, it is suggested that distinctly different seasonal strategies were used by early hunters on the AAR, with autumn hunting being carried out by small groups, and spring hunts being conducted by larger groups of cooperating hunters.

  4. Oral cancer statistics in India on the basis of first report of 29 population-based cancer registries

    PubMed Central

    Sharma, Swati; Satyanarayana, L; Asthana, Smitha; Shivalingesh, KK; Goutham, Bala Subramanya; Ramachandra, Sujatha

    2018-01-01

    Objectives: To summarize and provide an overview of age-specific oral cancer incidence reported in 29 population-based cancer registry in India. Materials and Methods: Secondary data on age-adjusted rates (AARs) of incidence of oral cancer and other associated sites for all ages (0–75 years) were collected from the report of the National Cancer Registry Programme 2012–2014 in 29 population-based control registries. Results: Among both males and females, mouth cancer had maximum Age adjusted incidence rates (64.8) in the central zone, while oropharynx cancer had minimum AAR (0) in all regions. Conclusion: Oral cancer incidence increases with age with typical pattern of cancer of associated sites of oral cavity seen in the northeast region. PMID:29731552

  5. Episodic Upwelling of Zooplankton within a Bowhead Whale Feeding Area Near Barrow, AK

    DTIC Science & Technology

    2013-09-30

    non-copepod prey. Bowhead (Balaena mysticetus) and beluga ( Delphinapterus leuca ) whales are the only Arctic endemic cetaceans that occur...Stafford, K.M., Okkonen, S.R., Clarke, J.T. 2013. Correlation of a strong Alaska Coastal Current with the presence of beluga whales ( Delphinapterus leucas ...Stafford, K.M., Okkonen, S.R., Clarke, J.T. 2013. Correlation of a strong Alaska Coastal Current with the presence of beluga whales ( Delphinapterus

  6. A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology.

    PubMed

    Macarrón, R; Mensah, L; Cid, C; Carranza, C; Benson, N; Pope, A J; Díez, E

    2000-09-10

    A new method to measure the aminoacylation of tRNA based upon the use of the scintillation proximity assay (SPA) technology has been developed. The assay detects incorporation of radiolabeled amino acids into cognate tRNA, catalyzed by a specific aminoacyl-tRNA synthetase (aaRS). Under acidic conditions, uncoated yttrium silicate SPA beads were found to bind tRNA aggregates, while the radiolabeled amino acid substrate remains in solution, resulting in good signal discrimination of these two species in the absence of any separation steps. The usefulness of this approach was demonstrated by measurement of steady-state kinetic constants and inhibitor binding constants for a range of aaRS enzymes in comparison with data from standard, trichloroacetic acid-precipitation-based assays. In all cases, the data were quantitatively comparable. Although the radioisotopic counting efficiency of the SPA method was less than that of standard liquid scintillation counting, the statistical performance (i.e., signal to background, variability, stability) of the SPA assays was at least equivalent to the separation-based methods. The assay was also shown to work well in miniaturized 384-well microtiter plate formats, resulting in considerable reagent savings. In summary, a new method to characterize aaRS activity is described that is faster and more amenable to high-throughput screening than traditional methods. Copyright 2000 Academic Press.

  7. Thoracic lymph node station recognition on CT images based on automatic anatomy recognition with an optimal parent strategy

    NASA Astrophysics Data System (ADS)

    Xu, Guoping; Udupa, Jayaram K.; Tong, Yubing; Cao, Hanqiang; Odhner, Dewey; Torigian, Drew A.; Wu, Xingyu

    2018-03-01

    Currently, there are many papers that have been published on the detection and segmentation of lymph nodes from medical images. However, it is still a challenging problem owing to low contrast with surrounding soft tissues and the variations of lymph node size and shape on computed tomography (CT) images. This is particularly very difficult on low-dose CT of PET/CT acquisitions. In this study, we utilize our previous automatic anatomy recognition (AAR) framework to recognize the thoracic-lymph node stations defined by the International Association for the Study of Lung Cancer (IASLC) lymph node map. The lymph node stations themselves are viewed as anatomic objects and are localized by using a one-shot method in the AAR framework. Two strategies have been taken in this paper for integration into AAR framework. The first is to combine some lymph node stations into composite lymph node stations according to their geometrical nearness. The other is to find the optimal parent (organ or union of organs) as an anchor for each lymph node station based on the recognition error and thereby find an overall optimal hierarchy to arrange anchor organs and lymph node stations. Based on 28 contrast-enhanced thoracic CT image data sets for model building, 12 independent data sets for testing, our results show that thoracic lymph node stations can be localized within 2-3 voxels compared to the ground truth.

  8. Molecular Evolution of Aminoacyl tRNA Synthetase Proteins in the Early History of Life

    NASA Astrophysics Data System (ADS)

    Fournier, Gregory P.; Andam, Cheryl P.; Alm, Eric J.; Gogarten, J. Peter

    2011-12-01

    Aminoacyl-tRNA synthetases (aaRS) consist of several families of functionally conserved proteins essential for translation and protein synthesis. Like nearly all components of the translation machinery, most aaRS families are universally distributed across cellular life, being inherited from the time of the Last Universal Common Ancestor (LUCA). However, unlike the rest of the translation machinery, aaRS have undergone numerous ancient horizontal gene transfers, with several independent events detected between domains, and some possibly involving lineages diverging before the time of LUCA. These transfers reveal the complexity of molecular evolution at this early time, and the chimeric nature of genomes within cells that gave rise to the major domains. Additionally, given the role of these protein families in defining the amino acids used for protein synthesis, sequence reconstruction of their pre-LUCA ancestors can reveal the evolutionary processes at work in the origin of the genetic code. In particular, sequence reconstructions of the paralog ancestors of isoleucyl- and valyl- RS provide strong empirical evidence that at least for this divergence, the genetic code did not co-evolve with the aaRSs; rather, both amino acids were already part of the genetic code before their cognate aaRSs diverged from their common ancestor. The implications of this observation for the early evolution of RNA-directed protein biosynthesis are discussed.

  9. β‐Endorphin, Met‐enkephalin and corresponding opioid receptors within synovium of patients with joint trauma, osteoarthritis and rheumatoid arthritis

    PubMed Central

    Mousa, Shaaban A; Straub, Rainer H; Schäfer, Michael; Stein, Christoph

    2007-01-01

    Objective Intra‐articularly applied opioid agonists or antagonists modulate pain after knee surgery and in chronic arthritis. Therefore, the expression of β‐endorphin (END), Met‐enkephalin (ENK), and μ and δ opioid receptors (ORs) within synovium of patients with joint trauma (JT), osteoarthritis (OA) and rheumatoid arthritis (RA) were examined. Methods Synovial samples were subjected to double immunohistochemical analysis of opioid peptides with immune cell markers, and of ORs with the neuronal markers calcitonin gene‐related peptide (CGRP) and tyrosine hydroxylase (TH). Results END and ENK were expressed by macrophage‐like (CD68+) and fibroblast‐like (CD68−) cells within synovial lining layers of all disorders. In the sublining layers, END and ENK were mostly expressed by granulocytes in patients with JT, and by macrophages/monocytes, lymphocytes and plasma cells in those with OA and RA. Overall, END‐ and ENK‐immunoreactive (IR) cells were more abundant in patients with RA than in those with OA and JT. ORs were found on nerve fibres and immune cells in all patients. OR‐IR nerve fibres were significantly more abundant in patients with RA than in those with OA and JT. μORs and δORs were coexpressed with CGRP but not with TH. Conclusions Parallel to the severity of inflammation, END and ENK in immune cells and their receptors on sensory nerve terminals are more abundant in patients with RA than in those with JT and OA. These findings are consistent with the notion that, with prolonged and enhanced inflammation, the immune and peripheral nervous systems upregulate sensory nerves expressing ORs and their ligands to counterbalance pain and inflammation. PMID:17324971

  10. MPI Enhancements in John the Ripper

    NASA Astrophysics Data System (ADS)

    Sykes, Edward R.; Lin, Michael; Skoczen, Wesley

    2010-11-01

    John the Ripper (JtR) is an open source software package commonly used by system administrators to enforce password policy. JtR is designed to attack (i.e., crack) passwords encrypted in a wide variety of commonly used formats. While parallel implementations of JtR exist, there are several limitations to them. This research reports on two distinct algorithms that enhance this password cracking tool using the Message Passing Interface. The first algorithm is a novel approach that uses numerous processors to crack one password by using an innovative approach to workload distribution. In this algorithm the candidate password is distributed to all participating processors and the word list is divided based on probability so that each processor has the same likelihood of cracking the password while eliminating overlapping operations. The second algorithm developed in this research involves dividing the passwords within a password file equally amongst available processors while ensuring load-balanced and fault-tolerant behavior. This paper describes John the Ripper, the design of these two algorithms and preliminary results. Given the same amount of time, the original JtR can crack 29 passwords, whereas our algorithms 1 and 2 can crack an additional 35 and 45 passwords respectively.

  11. Optical evidence of quantum rotor orbital excitations in orthorhombic manganites

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kovaleva, N. N., E-mail: nkovaleva@sci.lebedev.ru; Kugel, K. I.; Potůček, Z.

    2016-05-15

    In magnetic compounds with Jahn–Teller (JT) ions (such as Mn{sup 3+} or Cu{sup 2+}), the ordering of the electron or hole orbitals is associated with cooperative lattice distortions. There the role of JT effect, although widely recognized, is still elusive in the ground state properties. Here we discovered that, in these materials, there exist excitations whose energy spectrum is described in terms of the total angular momentum eigenstates and is quantized as in quantum rotors found in JT centers. We observed features originating from these excitations in the optical spectra of a model compound LaMnO{sub 3} using ellipsometry technique. Theymore » appear clearly as narrow sidebands accompanying the electron transition between the JT split orbitals at neighboring Mn{sup 3+} ions, displaying anomalous temperature behavior around the Néel temperature T{sub N} ≈ 140 K. We present these results together with new experimental data on photoluminescence found in LaMnO{sub 3}, which lend additional support to the ellipsometry implying the electronic-vibrational origin of the quantum rotor orbital excitations. We note that the discovered orbital excitations of quantum rotors may play an important role in many unusual properties observed in these materials upon doping, such as high-temperature superconductivity and colossal magnetoresistance.« less

  12. 49 CFR 1135.1 - Quarterly adjustment.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... railroad productivity as prescribed in Railroad Cost Recovery Procedures, 1 I.C.C.2d 207 (1984), and any subsequent amendments thereto. In addition, the AAR shall calculate the productivity-adjusted RCAF as...

  13. Minimum Information Dominating Set for Critical Sampling over Graphs

    DTIC Science & Technology

    2015-04-01

    NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) University of...not have identical VOSPs under µWl and µ W l′ . We insert D(µWl , µ W l′ ) ∪ (∪ k′ t=1D(µ Vit jt |µWl , µ Vit j′ t |µWl′ )) in- to E for every jt, j′t

  14. 77 FR 16916 - Airworthiness Directives; Pratt & Whitney (PW)Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... Airworthiness Directives; Pratt & Whitney (PW)Turbofan Engines AGENCY: Federal Aviation Administration (FAA... and -7R4H1 turbofan engines. This AD was prompted by the determination that a new lower life limit for... PW JT9D-7R4G2 and -7R4H1 turbofan engine models. We agree. In addition to the JT9D-7R4G2 and -7R4H1...

  15. Acquisition Management System and Data Requirements Control List

    DTIC Science & Technology

    1998-04-01

    o m Moio^Lnun o in ID r-or-r-r-vD -J (*) (N ^^jt^sJt^CN HÖH HHHHHH COCOCOLDCOCOCOCOCOCO r« o PH o PH pii PH 0- 0. PH r>l t...y^ w H W H H J Cfl W W W CO W CU ffi IX) P* CO Cft o CO CO CO CO Cft Cft o H oj rn o o o o HHHHHH OOOOOOOOOOOOOOHHH (N

  16. An Evaluation of the Requirements for Qualification and Warranting of Administrative Contracting Officers.

    DTIC Science & Technology

    1984-09-01

    Administration and Government Contract Law . Although respondents felt few of the courses provided in the questionnaire should be mandatory, they suggested other...2 weeks and 4 days Government Contract Law PPM 302 (JT) - 2 weeks 3. Senior Management of Managers 7A-F38 (.JT) - 2 weeks Defense Acquisition and...of the procurement cycle 3. Overview of budget and appropriation cycle 4. Ethics and conduct standards 5. Basic contract laws and regulations 6. Socio

  17. A 9,000-year-old caribou hunting structure beneath Lake Huron

    PubMed Central

    O’Shea, John M.; Lemke, Ashley K.; Sonnenburg, Elizabeth P.; Reynolds, Robert G.; Abbott, Brian D.

    2014-01-01

    Some of the most pivotal questions in human history necessitate the investigation of archaeological sites that are now under water. Nine thousand years ago, the Alpena-Amberley Ridge (AAR) beneath modern Lake Huron was a dry land corridor that connected northeast Michigan to southern Ontario. The newly discovered Drop 45 Drive Lane is the most complex hunting structure found to date beneath the Great Lakes. The site and its associated artifacts provide unprecedented insight into the social and seasonal organization of prehistoric caribou hunting. When combined with environmental and simulation studies, it is suggested that distinctly different seasonal strategies were used by early hunters on the AAR, with autumn hunting being carried out by small groups, and spring hunts being conducted by larger groups of cooperating hunters. PMID:24778246

  18. Routine blood tests to predict liver fibrosis in chronic hepatitis C.

    PubMed

    Hsieh, Yung-Yu; Tung, Shui-Yi; Lee, Kamfai; Wu, Cheng-Shyong; Wei, Kuo-Liang; Shen, Chien-Heng; Chang, Te-Sheng; Lin, Yi-Hsiung

    2012-02-28

    To verify the usefulness of FibroQ for predicting fibrosis in patients with chronic hepatitis C, compared with other noninvasive tests. This retrospective cohort study included 237 consecutive patients with chronic hepatitis C who had undergone percutaneous liver biopsy before treatment. FibroQ, aspartate aminotransferase (AST)/alanine aminotransferase ratio (AAR), AST to platelet ratio index, cirrhosis discriminant score, age-platelet index (API), Pohl score, FIB-4 index, and Lok's model were calculated and compared. FibroQ, FIB-4, AAR, API and Lok's model results increased significantly as fibrosis advanced (analysis of variance test: P < 0.001). FibroQ trended to be superior in predicting significant fibrosis score in chronic hepatitis C compared with other noninvasive tests. FibroQ is a simple and useful test for predicting significant fibrosis in patients with chronic hepatitis C.

  19. Arrhythmogenic drugs can amplify spatial heterogeneities in the electrical restitution in perfused guinea-pig heart: An evidence from assessments of monophasic action potential durations and JT intervals

    PubMed Central

    2018-01-01

    Non-uniform shortening of the action potential duration (APD90) in different myocardial regions upon heart rate acceleration can set abnormal repolarization gradients and promote arrhythmia. This study examined whether spatial heterogeneities in APD90 restitution can be amplified by drugs with clinically proved proarrhythmic potential (dofetilide, quinidine, procainamide, and flecainide) and, if so, whether these effects can translate to the appropriate changes of the ECG metrics of ventricular repolarization, such as JT intervals. In isolated, perfused guinea-pig heart preparations, monophasic action potentials and volume-conducted ECG were recorded at progressively increased pacing rates. The APD90 measured at distinct ventricular sites, as well as the JTpeak and JTend values were plotted as a function of preceding diastolic interval, and the maximum slopes of the restitution curves were determined at baseline and upon drug administration. Dofetilide, quinidine, and procainamide reverse rate-dependently prolonged APD90 and steepened the restitution curve, with effects being greater at the endocardium than epicardium, and in the right ventricular (RV) vs. the left ventricular (LV) chamber. The restitution slope was increased to a greater extent for the JTend vs. the JTpeak interval. In contrast, flecainide reduced the APD90 restitution slope at LV epicardium without producing effect at LV endocardium and RV epicardium, and reduced the JTpeak restitution slope without changing the JTend restitution. Nevertheless, with all agents, these effects translated to the amplified epicardial-to-endocardial and the LV-to-RV non-uniformities in APD90 restitution, paralleled by the increased JTend vs. JTpeak difference in the restitution slope. In summary, these findings suggest that arrhythmic drug profiles are partly attributable to the accentuated regional heterogeneities in APD90 restitution, which can be indirectly determined through ECG assessments of the JTend vs. JTpeak

  20. Arrhythmogenic drugs can amplify spatial heterogeneities in the electrical restitution in perfused guinea-pig heart: An evidence from assessments of monophasic action potential durations and JT intervals.

    PubMed

    Osadchii, Oleg E

    2018-01-01

    Non-uniform shortening of the action potential duration (APD90) in different myocardial regions upon heart rate acceleration can set abnormal repolarization gradients and promote arrhythmia. This study examined whether spatial heterogeneities in APD90 restitution can be amplified by drugs with clinically proved proarrhythmic potential (dofetilide, quinidine, procainamide, and flecainide) and, if so, whether these effects can translate to the appropriate changes of the ECG metrics of ventricular repolarization, such as JT intervals. In isolated, perfused guinea-pig heart preparations, monophasic action potentials and volume-conducted ECG were recorded at progressively increased pacing rates. The APD90 measured at distinct ventricular sites, as well as the JTpeak and JTend values were plotted as a function of preceding diastolic interval, and the maximum slopes of the restitution curves were determined at baseline and upon drug administration. Dofetilide, quinidine, and procainamide reverse rate-dependently prolonged APD90 and steepened the restitution curve, with effects being greater at the endocardium than epicardium, and in the right ventricular (RV) vs. the left ventricular (LV) chamber. The restitution slope was increased to a greater extent for the JTend vs. the JTpeak interval. In contrast, flecainide reduced the APD90 restitution slope at LV epicardium without producing effect at LV endocardium and RV epicardium, and reduced the JTpeak restitution slope without changing the JTend restitution. Nevertheless, with all agents, these effects translated to the amplified epicardial-to-endocardial and the LV-to-RV non-uniformities in APD90 restitution, paralleled by the increased JTend vs. JTpeak difference in the restitution slope. In summary, these findings suggest that arrhythmic drug profiles are partly attributable to the accentuated regional heterogeneities in APD90 restitution, which can be indirectly determined through ECG assessments of the JTend vs. JTpeak

  1. Survey of Freight Car Roller Bearing Requirements and Failure Modes

    DOT National Transportation Integrated Search

    1973-07-01

    AAR roller bearing requirements and interchange rules are presented and reviewed; also included and reviewed are rules covering adapters and grease for freight car bearings. Bearing fatigue theory, methods of fatigue life calculations, and characteri...

  2. Acoustic detection of rail car roller bearing defects. Phase III, System evaluation test.

    DOT National Transportation Integrated Search

    2003-08-01

    In July 1999, Transportation Technology Center, Inc. (TTCI), a subsidiary of the Association of American Railroads (AAR), conducted a system evaluation test as part of the Federal Railroad Administrations (FRA) Improved Freight Car Roller Bearing ...

  3. Use of Computer Simulation for the Analysis of Railroad Operations in the St. Louis Terminal Area

    DOT National Transportation Integrated Search

    1977-11-01

    This report discusses the computer simulation methodology, its uses and limitations, and its applicability to the analysis of alternative railroad terminal restructuring plans. Included is a detailed discussion of the AAR Simulation System, an overvi...

  4. Influence of performance level on anaerobic power and body composition in elite male judoists.

    PubMed

    Kim, Jongkyu; Cho, Hyun-Chul; Jung, Han-Sang; Yoon, Jong-Dae

    2011-05-01

    This study examined the relationship between 30-second anaerobic power and body composition by performance level in elite Judoists. During a 3-month period, 10 male Korean Judo national team athletes (NT), 26 male university varsity team athletes (VT), and 28 male junior varsity team athletes (JT) were assessed for 30-second anaerobic power and body composition at the Youngin University. Anaerobic power was measured using a 30-second Wingate test. Body composition was assessed via bioelectric impedance analysis in standardized conditions using BioSpace (Korean)-specific prediction formulas. All testing occurred at the beginning of the winter nonseason period but excluded a brief weight-loss period before the competition phase. Anaerobic power measures were significantly greater (p < 0.05) in NT and VT than in JT. Fat-free mass (FFM), muscle mass (MM), and total body water in JT were also greater than in VT and JT (p < 0.05). Muscle mass in VT was significantly lower than in NT (p < 0.05). Fat-free mass in NT was strongly correlated to mean and peak anaerobic power (r = 0.77, p = 0.009; r = 0.87, p < 0.001, respectively). Varsity team athletes also indicated a moderate association between FFM and peak and mean anaerobic power (r = 0.63, p < 0.001; r = 0.48, p = 0.013, respectively). However, relationship between FFM and anaerobic power was not statistically significantly correlated in JT (r = 0.14, p = 0.470; r = 0.23, p = 0.232, separately). In conclusion, our data indicated that anaerobic power is closely correlated with increase in FFM and MM and was different dependent among performance levels. Further research in the field is warranted to elucidate the Judo-specific relationship between FFM and performance.

  5. Balance of the stored energies sustained by the internal and edge transport barriers and effects of ELMs and L-H transitions in JT-60U

    NASA Astrophysics Data System (ADS)

    Kamada, Y.; Yoshida, M.; Sakamoto, Y.; Koide, Y.; Oyama, N.; Urano, H.; Kamiya, K.; Suzuki, T.; Isayama, A.; JT-60 Team

    2009-09-01

    To understand key physics processes determining radial profiles of the kinetic plasma parameters in the advanced tokamak operation scenarios, correlations between the edge transport barrier (ETB) and the internal transport barrier (ITB) have been studied in the JT-60U tokamak device. It has been found that the edge pedestal poloidal beta, βp-ped, increases almost linearly with the total poloidal beta, βp-tot, over a wide range of the plasma current for type I ELMing H-mode plasmas, and this dependence becomes stronger with increasing triangularity. This dependence is not due to the profile stiffness, since the dependence is the same regardless of the existence of ITB. As the stored energy inside the ITB-foot radius (WITB) increases, the total thermal stored energy (Wth) increases and then the pedestal stored energy (Wped) increases. On the other hand, as Wped increases, the ELM penetration expands more inwards and finally reaches the ITB-foot radius. At this situation, the ITB-foot radius cannot move outwards because of the erosion by ELMs. Then the fractions of WITB/Wth and Wped/Wth become almost constant. It has also been found that the type I ELM expels/decreases the edge toroidal momentum larger than the edge ion thermal energy. The ELM penetration for the toroidal rotation tends to be deeper than that for the ion temperature and can exceed the ITB-foot radius. The ELM penetration is deeper for CO-rotating plasmas than CTR rotating plasmas. In both cases, the ELM penetration is deeper in the order of the toroidal rotation (Vt), the ion temperature (Ti) and then the electron temperature (Te). The L-H transition also changes the Vt profile more significantly than the Ti profile. At the L-H transition, the pedestal Vt shifts into the CTR-direction deeply and suddenly without a change in Ti, and then the pedestal Vt grows further together with a growth of the pedestal Ti in a slower timescale. Such changes in Vt by ELMs and L-H transitions may affect degradation

  6. Private Sector Involvement in Urban Transportation: Case Studies

    DOT National Transportation Integrated Search

    1984-07-01

    This report describes the development of formulas which predict the severity of accidents at public rail-highway crossings. They employ the previously developed DOT accident prediction formula, U.S. DOT-AAR National Rail-Highway Crossing Inventory, a...

  7. Development of helium electron cyclotron wall conditioning on TCV

    NASA Astrophysics Data System (ADS)

    Douai, D.; Goodman, T.; Isayama, A.; Fukumoto, M.; Wauters, T.; Sozzi, C.; Coda, S.; Blanchard, P.; Figini, L.; Garavaglia, S.; Miyata, Y.; Moro, A.; Ricci, D.; Silva, M.; Theiler, C.; Vartanian, S.; Verhaegh, K.; the EUROfusion MST1 Team; the TCV Team

    2018-02-01

    JT-60SA envisions electron cyclotron wall conditioning (ECWC), as wall conditioning method in the presence of the toroidal field to control fuel and impurity recycling and to improve plasma performance and reproducibility. This paper reports on Helium ECWC experiments on TCV in support of JT-60SA operation. Nearly sixty Helium conditioning discharges have been successfully produced in TCV, at a toroidal field B T  =  1.3 or 1.54 T, with gyrotrons at 82.7 GHz in X2 mode, mimicking ECWC operation in JT-60SA at the second harmonic of the EC wave. Discharge parameters were tuned in order to (i) minimize the time for the onset of ECWC plasmas, thus minimizing absorption of stray radiation by in-vessel components, (ii) improve discharge homogeneity by extending the discharge vertically and radially, and wall coverage, in particular of inboard surfaces where JT-60SA plasmas will be initiated, (iii) assess the efficiency of He-ECWC to deplete carbon walls from fuel. An optimized combination of vertical and radial magnetic fields, with amplitudes typically 0.1 to 0.6% of that of B T, has been determined, which resulted in lowest breakdown time, improved wall coverage and enhanced fuel removal. A standard ohmic D 2-plasma could be then sustained, whereas it would not have been possible without He-ECWC.

  8. Temporal dominance of sensations and preferences of Brazilians and Slovakians: A cross-cultural study of cachaças stored with woods from the Amazon rainforest.

    PubMed

    Simioni, Síntia Carla Corrêa; Tovar, Diego Mercado; Rodrigues, Jéssica Ferreira; de Souza, Vanessa Rios; Nunes, Cleiton Antônio; Vietoris, Vladimir; Pinheiro, Ana Carla Marques

    2018-02-01

    Brazilians and Slovakians evaluated the temporal profile and the acceptability of cachaça stored with different woods (Cumarurana (CM), Jatobá (JT) and, Louro-vermelho (LV), which are found in the Amazon rainforest, and also oak), with the aim of performing a cross-cultural comparison of the dynamic profile of the attributes perceived in the cachaças and the sensorial acceptance of the samples. Important differences were observed between the temporal sensorial profiles generated by the two groups and their preferences. Brazilians preferred cachaças stored with the traditional wood, oak, followed by those stored with JT and CM. In contrast, Slovakians preferred cachaças stored with JT, followed by those stored with LV and oak. For both countries, the dominance of wood flavor and vanilla attributes at the end of the analysis time was positively associated with acceptance, while the dominance of off-flavors and the wood flavor attribute at the beginning of the analysis time was negatively associated with acceptance for Brazilians and Slovakians, respectively. Brazilians preferred cachaça stored with oak wood, and Slovakians preferred cachaça stored with JT wood, with acceptability being strongly associated with the dominance of wood flavor and vanilla attributes at the end of the evaluation time. © 2018 Society of Chemical Industry. © 2018 Society of Chemical Industry.

  9. Two-stage, low noise advanced technology fan. 5: Acoustic final report

    NASA Technical Reports Server (NTRS)

    Sofrin, T. G.; Riloff, N., Jr.

    1975-01-01

    The NASA Q2S(quiet two-stage) fan is a 0.836m (32.9 in.) diameter model of the STF 433 engine fan, selected in a 1972 study for an Advanced Technology Transport (ATT) airplane. Noise-control features include: low tip speed, moderate stage pressure rise, large blade-vane spacings, no inlet guide vanes, and optimum blade and vane numbers. Tests were run on the baseline Q2S fan with standard inlet and discharge ducts. Further tests were made of a translating centerbody sonic inlet device and treated discharge ducts. Results were scaled to JT8D and JT3D engine fan size for comparison with current two-stage fans, and were also scaled to STF 433 fan size to compare calculated ATT flyover noise with FAR 36 limits. Baseline Q2S results scaled to JT8D and JT3D engine fan sizes showed substantial noise reductions. Calculated unsuppressed baseline ATT flyovers averaged about 2.5 EPNdB below FAR 36 limits. Using measured sonic inlet results, scaled baseline Q2S fan results, and calculated attenuations for a 1975 technology duct liner, projected flyover noise calculations for the ATT averaged about FAR 36 limits minus 10 EPNdB. Advances in suppression technology required to meet the 1985 goal of FAR 36 limits minus 20 EPNdB are discussed.

  10. Isotopic evidence for a large-scale plume-derived mantle domain between the Indian and Pacific mantles beneath the Southern Ocean.

    NASA Astrophysics Data System (ADS)

    Park, S. H.; Langmuir, C. H.; Scott, S. R.; Sims, K. W. W.; Lin, J.; Kim, S. S.; Blichert-Toft, J.; Choi, H.; Yang, Y. S.; Michael, P. J.

    2017-12-01

    Earth's upper mantle is characterized by Indian- and Pacific-type domains with distinctive isotope characteristics. The boundary between these two mantle regions has been hypothesized to be located at the Australian-Antarctic-Discordance (AAD), where regions west and east of the AAD are Indian- and Pacific-type, respectively. It was further posited that the Pacific mantle feeds into the Indian mantle as the boundary is moving westward. These scenarios have important implications for the dynamics of mantle convection in the area. In the present model, regions east of the AAD are assumed to be entirely Pacific-type mantle, but our recent recovery of basalts from a 2,000-km sampling gap along the Australian-Antarctic Ridge (AAR), located east of the AAD on the Pacific side, challenges this picture. Here we show that the Hf, Nd, Pb, and Sr isotopic compositions of AAR MORB are distinct from those of Pacific and Indian MORB. Rather, the AAR lavas show mixing relationships with volcanoes from the Hikurangi seamounts, the Balleney and Scott Islands, the West Antarctic Rift System, New Zealand, and east Australia. According to tectonic reconstruction models, these volcanoes are related to super-plume activity that caused Gondwana to break up at 90 Ma. These results imply that a large-scale plume-derived mantle domain exists between the Indian and Pacific mantle domains, and that mantle dynamics along the AAD should be reinterpreted in light of interaction with a super-plume.

  11. Importance of single molecular determinants in the fidelity of expanded genetic codes.

    PubMed

    Antonczak, Alicja K; Simova, Zuzana; Yonemoto, Isaac T; Bochtler, Matthias; Piasecka, Anna; Czapinska, Honorata; Brancale, Andrea; Tippmann, Eric M

    2011-01-25

    The site-selective encoding of noncanonical amino acids (NAAs) is a powerful technique for the installation of novel chemical functional groups in proteins. This is often achieved by recoding a stop codon and requires two additional components: an evolved aminoacyl tRNA synthetase (AARS) and a cognate tRNA. Analysis of the most successful AARSs reveals common characteristics. The highest fidelity NAA systems derived from the Methanocaldococcus jannaschii tyrosyl AARS feature specific mutations to two residues reported to interact with the hydroxyl group of the substrate tyrosine. We demonstrate that the restoration of just one of these determinants for amino acid specificity results in the loss of fidelity as the evolved AARSs become noticeably promiscuous. These results offer a partial explanation of a recently retracted strategy for the synthesis of glycoproteins. Similarly, we reinvestigated a tryptophanyl AARS reported to allow the site-selective incorporation of 5-hydroxy tryptophan within mammalian cells. In multiple experiments, the enzyme displayed elements of promiscuity despite its previous characterization as a high fidelity enzyme. Given the many similarities of the TyrRSs and TrpRSs reevaluated here, our findings can be largely combined, and in doing so they reinforce the long-established central dogma regarding the molecular basis by which these enzymes contribute to the fidelity of translation. Thus, our view is that the central claims of fidelity reported in several NAA systems remain unproven and unprecedented.

  12. Importance of single molecular determinants in the fidelity of expanded genetic codes

    PubMed Central

    Antonczak, Alicja K.; Simova, Zuzana; Yonemoto, Isaac T.; Bochtler, Matthias; Piasecka, Anna; Czapińska, Honorata; Brancale, Andrea; Tippmann, Eric M.

    2011-01-01

    The site-selective encoding of noncanonical amino acids (NAAs) is a powerful technique for the installation of novel chemical functional groups in proteins. This is often achieved by recoding a stop codon and requires two additional components: an evolved aminoacyl tRNA synthetase (AARS) and a cognate tRNA. Analysis of the most successful AARSs reveals common characteristics. The highest fidelity NAA systems derived from the Methanocaldococcus jannaschii tyrosyl AARS feature specific mutations to two residues reported to interact with the hydroxyl group of the substrate tyrosine. We demonstrate that the restoration of just one of these determinants for amino acid specificity results in the loss of fidelity as the evolved AARSs become noticeably promiscuous. These results offer a partial explanation of a recently retracted strategy for the synthesis of glycoproteins. Similarly, we reinvestigated a tryptophanyl AARS reported to allow the site-selective incorporation of 5-hydroxy tryptophan within mammalian cells. In multiple experiments, the enzyme displayed elements of promiscuity despite its previous characterization as a high fidelity enzyme. Given the many similarities of the TyrRSs and TrpRSs reevaluated here, our findings can be largely combined, and in doing so they reinforce the long-established central dogma regarding the molecular basis by which these enzymes contribute to the fidelity of translation. Thus, our view is that the central claims of fidelity reported in several NAA systems remain unproven and unprecedented. PMID:21224416

  13. Pharmacologic Effects of Cannabidiol on Acute Reperfused Myocardial Infarction in Rabbits: Evaluated With 3.0T Cardiac Magnetic Resonance Imaging and Histopathology.

    PubMed

    Feng, Yuanbo; Chen, Feng; Yin, Ting; Xia, Qian; Liu, Yewei; Huang, Gang; Zhang, Jian; Oyen, Raymond; Ni, Yicheng

    2015-10-01

    Cannabidiol (CBD) has anti-inflammatory effects. We explored its therapeutic effects on cardiac ischemia-reperfusion injury with an experimental imaging platform. Reperfused acute myocardial infarction (AMI) was induced in rabbits with a 90-minute coronary artery occlusion followed by 24-hour reperfusion. Before reperfusion, rabbits received 2 intravenous doses of 100 μg/kg CBD (n = 10) or vehicle (control, n = 10). Evans blue was intravenously injected for later detection of the AMI core. Cardiac magnetic resonance imaging was performed to evaluate cardiac morphology and function. After euthanasia, blood troponin I (cTnI) was assessed, and the heart was excised and infused with multifunctional red iodized oil dye. The heart was sliced for digital radiography to quantify the perfusion density rate, area at risk (AAR), and myocardial salvage index, followed by histomorphologic staining. Compared with controls, CBD treatment improved systolic wall thickening (P < 0.05), significantly increased blood flow in the AAR (P < 0.05), significantly decreased microvascular obstruction (P < 0.05), increased the perfusion density rate by 1.7-fold, lowered the AMI core/AAR ratio (P < 0.05), and increased the myocardial salvage index (P < 0.05). These improvements were associated with reductions in serum cTnI, cardiac leukocyte infiltration, and myocellular apoptosis (P < 0.05). Thus, CBD therapy reduced AMI size and facilitated restoration of left ventricular function. We demonstrated that this experimental platform has potential theragnostic utility.

  14. Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2α/ATF4 Pathway

    PubMed Central

    Carraro, Valérie; Maurin, Anne-Catherine; Lambert-Langlais, Sarah; Averous, Julien; Chaveroux, Cédric; Parry, Laurent; Jousse, Céline; Örd, Daima; Örd, Tõnis; Fafournoux, Pierre; Bruhat, Alain

    2010-01-01

    In mammals, plasma amino acid concentrations are markedly affected by dietary or pathological conditions. It has been well established that amino acids are involved in the control of gene expression. Up to now, all the information concerning the molecular mechanisms involved in the regulation of gene transcription by amino acid availability has been obtained in cultured cell lines. The present study aims to investigate the mechanisms involved in transcriptional activation of the TRB3 gene following amino acid limitation in mice liver. The results show that TRB3 is up-regulated in the liver of mice fed a leucine-deficient diet and that this induction is quickly reversible. Using transient transfection and chromatin immunoprecipitation approaches in hepatoma cells, we report the characterization of a functional Amino Acid Response Element (AARE) in the TRB3 promoter and the binding of ATF4, ATF2 and C/EBPβ to this AARE sequence. We also provide evidence that only the binding of ATF4 to the AARE plays a crucial role in the amino acid-regulated transcription of TRB3. In mouse liver, we demonstrate that the GCN2/eIF2α/ATF4 pathway is essential for the induction of the TRB3 gene transcription in response to a leucine-deficient diet. Therefore, this work establishes for the first time that the molecular mechanisms involved in the regulation of gene transcription by amino acid availability are functional in mouse liver. PMID:21203563

  15. Acoustic detection of roller bearing defects. Phase II, Field test.

    DOT National Transportation Integrated Search

    2000-08-01

    The Transportation Technology Center, Inc. (TTCI), a subsidiary of the Association of American Railroads (AAR) Research and Test Department, conducted a series of simulated revenue service tests with a train of eight cars containing wheel sets with s...

  16. Assessing Patterns of Change in Anthropometric Dimensions: Secular Trends of U.S. Army Females, 1946-1988

    DTIC Science & Technology

    1993-01-01

    Pevdlct Amy’ wIz’u bod dlzmuiui valiues In the rner ftAbze. 14. SUBJECT TERMS ARMY PERSONNEL MODELS i 5 NUMBER OF PAGES ANTHROPOMETRY RACE( ANTHROPOLOGY...Distributions of Serial Changes in Stature and Weight in a Healthy Elderly Population. Human Biology 60:917-925. Clauser, CE, JT McConville, CC...MA Index in a British Cohort. Annals of Human Biology 16:1-8. Laubach, LL, JT McConville, E Churchill and RM White (1977a) Anthropometry of Women of

  17. Joint Services Electronics Program.

    DTIC Science & Technology

    1985-03-30

    Greenberg , Research Assistant LCE 17FI’w C OBJECTIVE: The general objective of this research unit is to study the interaction of excited molecules...helium - SiH mixtures. REFIRNCES: 1. V.M. Donnelly, D.C Flamn, WC. Dantremont-Smith, DJ. Werder, J. AppL Phys. 53,242 (1983. 2. KE. Greenberg , G.A...Hebner, and J.T. Verdeyen, Appl. Phys. Lett. 44, 299 (1984). 3. K.E. Greenberg , J.T. Verdeyen, J. Appl. Phys. 57, 1596 (1985). PUBLICATION& .0 Journal

  18. Modeling and Optimization for Epitaxial Growth: Transport and Growth Studies

    DTIC Science & Technology

    1999-01-01

    effect . It is expressed as the sum of these two components j i jC i jT i where jC i and jT i denote the concentration driven and thermally driven...improve manufacturing effectiveness for epitaxial growth of silicon and silicon-germanium (Si-Ge) thin films on a silicon wafer. Growth takes place in the...non-uniformity to compensate for the effects of other phenomena such as reactant depletion, gas heating and gas phase reactions, thermal diffusion of

  19. Operating Modes and Cooling Capabilities of the 3-Stage ADR Developed for the Soft-X-ray Spectrometer Instrument on Astro-H

    PubMed Central

    Shirron, Peter J; Kimball, Mark O; James, Bryan L; Muench, Theo; DiPirro, Michael J; Letmate, Richard V; Sampson, Michael A; Bialas, Tom G; Sneiderman, Gary A; Porter, Frederick S; Kelley, Richard L

    2017-01-01

    A 3-stage adiabatic demagnetization refrigerator (ADR)[1] is used on the Soft X-ray Spectrometer instrument[2] on Astro-H[3] to cool a 6×6 array of x-ray microcalorimeters to 50 mK. The ADR is supported by a cryogenic system[4] consisting of a superfluid helium tank, a 4.5 K Joule-Thomson (JT) cryocooler, and additional 2-stage Stirling cryocoolers that pre-cool the JT cooler and cool radiation shields within the cryostat. The ADR is configured so that it can use either the liquid helium or the JT cryocooler as its heat sink, giving the instrument an unusual degree of tolerance for component failures or degradation in the cryogenic system. The flight detector assembly, ADR and dewar were integrated into the flight dewar in early 2014, and have since been extensively characterized and calibrated. This paper summarizes the operation and performance of the ADR in all of its operating modes. PMID:28111478

  20. Operating Modes and Cooling Capabilities of the 3-Stage ADR Developed for the Soft-X-ray Spectrometer Instrument on Astro-H.

    PubMed

    Shirron, Peter J; Kimball, Mark O; James, Bryan L; Muench, Theo; DiPirro, Michael J; Letmate, Richard V; Sampson, Michael A; Bialas, Tom G; Sneiderman, Gary A; Porter, Frederick S; Kelley, Richard L

    2016-03-01

    A 3-stage adiabatic demagnetization refrigerator (ADR)[1] is used on the Soft X-ray Spectrometer instrument[2] on Astro-H[3] to cool a 6×6 array of x-ray microcalorimeters to 50 mK. The ADR is supported by a cryogenic system[4] consisting of a superfluid helium tank, a 4.5 K Joule-Thomson (JT) cryocooler, and additional 2-stage Stirling cryocoolers that pre-cool the JT cooler and cool radiation shields within the cryostat. The ADR is configured so that it can use either the liquid helium or the JT cryocooler as its heat sink, giving the instrument an unusual degree of tolerance for component failures or degradation in the cryogenic system. The flight detector assembly, ADR and dewar were integrated into the flight dewar in early 2014, and have since been extensively characterized and calibrated. This paper summarizes the operation and performance of the ADR in all of its operating modes.

  1. Operating Modes and Cooling Capabilities of the 3-Stage ADR Developed for the Soft-X-Ray Spectrometer Instrument on Astro-H

    NASA Technical Reports Server (NTRS)

    Shirron, Peter J.; Kimball, Mark O.; James, Bryan L.; Muench, Theo; DiPirro, Michael J.; Letmate, Richard V.; Sampson, Michael A.; Bialas, Tom G.; Sneiderman, Gary A.; Porter, Frederick S.; hide

    2015-01-01

    A 3-stage adiabatic demagnetization refrigerator (ADR) is used on the Soft X-ray Spectrometer instrument on Astro-H to cool a 6x6 array of x-ray microcalorimeters to 50 mK. The ADR is supported by a cryogenic system consisting of a superfluid helium tank, a 4.5 K Joule-Thomson (JT) cryocooler, and additional 2-stage Stirling cryocoolers that pre-cool the JT cooler and cool radiation shields within the cryostat. The ADR is configured so that it can use either the liquid helium or the JT cryocooler as its heat sink, giving the instrument an unusual degree of tolerance for component failures or degradation in the cryogenic system. The flight detector assembly, ADR and dewar were integrated into the flight dewar in early 2014, and have since been extensively characterized and calibrated. This paper summarizes the operation and performance of the ADR in all of its operating modes

  2. JT Bachman Leadership Framework

    DTIC Science & Technology

    2017-07-01

    has been reviewed by Mr. Ray E. Poff, Head, Missile Systems Engineering and Integration Branch (H33), and Mr. Steven L. Collignon, Head, Missile...promotes participation in the above mentioned resources will enhance the careers of individuals while accomplishing the mission goals of the organization...in which people seek to be accountable to themselves and their team members. As a leader, evaluate whether one’s career passion meshes with the

  3. The Use of Cognitive Task Analysis and Simulators for After Action Review of Medical Events in Iraq

    DTIC Science & Technology

    2007-03-01

    research attempts to improve medical AAR with a novel combination of Cognitive Task Analysis (CTA) conducted while interviewees moulage simulators...combination of medical Cognitive Task Analysis combined with the moulage of instruments and depictions of the femoral artery will more accurately

  4. 49 CFR 179.3 - Procedure for securing approval.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS... Safety, AAR, for consideration by its Tank Car Committee and other appropriate committees. Approval or... designs, materials and construction, conversion or alteration of tank car tanks under these specifications...

  5. 49 CFR 179.3 - Procedure for securing approval.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS... Safety, AAR, for consideration by its Tank Car Committee and other appropriate committees. Approval or... designs, materials and construction, conversion or alteration of tank car tanks under these specifications...

  6. 49 CFR 179.3 - Procedure for securing approval.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS... Safety, AAR, for consideration by its Tank Car Committee and other appropriate committees. Approval or... designs, materials and construction, conversion or alteration of tank car tanks under these specifications...

  7. 49 CFR 179.3 - Procedure for securing approval.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS... Safety, AAR, for consideration by its Tank Car Committee and other appropriate committees. Approval or... designs, materials and construction, conversion or alteration of tank car tanks under these specifications...

  8. 49 CFR 179.3 - Procedure for securing approval.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Executive Director—Tank Car Safety, AAR, for consideration by its Tank Car Committee and other appropriate... SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Introduction, Approvals and Reports § 179.3 Procedure for securing approval. (a) Application...

  9. Bus Driver Fatigue and Stress Issues Study. Final Report

    DOT National Transportation Integrated Search

    1984-04-01

    The study has determined the safety effectiveness of various types of motorist warning devices in reducing accidents at rail-highway crossings. The study was based on analysis of data included in the DOT-AAR Rail-Highway Crossing Inventory and the FR...

  10. 49 CFR 229.217 - Fuel tank.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Locomotive Crashworthiness Design Requirements § 229.217 Fuel..., comply with the requirements of AAR S-5506, “Performance Requirements for Diesel Electric Locomotive Fuel...

  11. ATHENA X-IFU 300 K-50 mK cryochain demonstrator cryostat

    NASA Astrophysics Data System (ADS)

    Prouvé, T.; Duval, J. M.; Charles, I.; Yamasaki, N. Y.; Mitsuda, K.; Nakagawa, T.; Shinozaki, K.; Tokoku, C.; Yamamoto, R.; Minami, Y.; Le Du, M.; Andre, J.; Daniel, C.; Linder, M.

    2018-01-01

    In the framework of the ESA X-ray mission ATHENA, scheduled for launch in 2028, an ESA Core Technology Program (CTP) was started in 2016 to build a flight like cryostat demonstrator in parallel with the phase A studies of the ATHENA/X-IFU instrument [1,2]. As part of this CTP, called the Detector Cooling System (DCS), design, manufacturing and test of a cryostat including existing space coolers will be done. In addition to the validation of thermal performance, a Focal Plan Assembly (FPA) demonstrator using Transition Edge Sensors (TES) detector technology will be also integrated and its performance characterized versus the environment provided by the cryostat. This is a unique opportunity to validate many crucial issues of the cryogenic part of such a sensitive instrument. A dedicated activity within this CTP-DCS is the demonstration of the 300 K-50 mK cooling chain in a Ground System Equipment (GSE) cryostat. The studies are focused on the operation of the space coolers, which is made possible by the use of a ground cooler for cooling cryogenic shields and mechanical supports. Thanks to the modularity of the cryostat, several cooling chains could be tested. In the base line configuration described here, the low temperature stage is the CEA hybrid sorption/ADR 50 mK cooler with thermal interfaces at 4 K and 2 K. 4 K cooling is accomplished by a 4 K Joule-Thomson (JT) cryocooler and its Stirling precooler provided by JAXA. Regarding the 2 K stage, at first a 2 K JT from JAXA will be used. Alternatively, a 2 K JT cooler from RAL could replace the JAXA 2 K JT. In both cases new prototype(s) of a 2 K JT will be implemented, precooled by the EM 15 K pule tube cooler from Air Liquide. This test program is also the opportunity to validate the operation of the cryochain with respect to various requirements, such as time constant and temperature stabilities. This would bring us valuable inputs to integrate the cryochain in DCS cryostat or for the X-IFU phase A studies

  12. Jumping translocations of 1q12 in multiple myeloma: a novel mechanism for deletion of 17p in cytogenetically defined high-risk disease.

    PubMed

    Sawyer, Jeffrey R; Tian, Erming; Heuck, Christoph J; Epstein, Joshua; Johann, Donald J; Swanson, Charles M; Lukacs, Janet L; Johnson, Marian; Binz, Regina; Boast, Angela; Sammartino, Gael; Usmani, Saad; Zangari, Maurizio; Waheed, Sarah; van Rhee, Frits; Barlogie, Bart

    2014-04-17

    Multiple myeloma (MM) is a B-cell malignancy driven in part by increasing copy number alterations (CNAs) during disease progression. Prognostically significant CNAs accumulate during clonal evolution and include gains of 1q21 and deletions of 17p, among others. Unfortunately, the mechanisms underlying the accumulation of CNAs and resulting subclonal heterogeneity in high-risk MM are poorly understood. To investigate the impact of jumping translocations of 1q12 (JT1q12) on receptor chromosomes (RCs) and subsequent clonal evolution, we analyzed specimens from 86 patients selected for unbalanced 1q12 aberrations by G-banding. Utilizing spectral karyotyping and locus-specific fluorescence in situ hybridization, we identified 10 patients with unexpected focal amplifications of an RC that subsequently translocated as part of a sequential JT1q12 to one or more additional RCs. Four patients exhibited amplification and translocation of 8q24 (MYC), 3 showed amplification of 16q11, and 1 each displayed amplification of 18q21.3 (BCL2), 18q23, or 4p16 (FGFR3). Unexpectedly, in 6 of 14 patients with the combination of the t(4;14) and deletion of 17p, we identified the loss of 17p as resulting from a JT1q12. Here, we provide evidence that the JT1q12 is a mechanism for the simultaneous gain of 1q21 and deletion of 17p in cytogenetically defined high-risk disease.

  13. Anisotropic orbital occupation and Jahn-Teller distortion of orthorhombic YMnO{sub 3} epitaxial films: A combined experimental and theoretical study on polarization-dependent x-ray absorption spectroscopy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Haw, Shu-Chih; Chen, Shin-Ann; National Synchrotron Radiation Research Center

    2014-04-21

    The b-axis oriented orthorhombic YMnO{sub 3} (o-YMnO{sub 3}) epitaxial films on a YAlO{sub 3} (010) substrate were fabricated with pulsed-laser deposition. The anisotropic orbital occupation and Jahn-Teller (JT) distortion of an o-YMnO{sub 3} film were investigated with polarization-dependent x-ray absorption spectra and configuration-interaction multiplet-cluster calculations. A significant energy difference, ∼3.8 eV, for the main white line along E//b and E//a in polarization-dependent Mn K-edge spectra of o-YMnO{sub 3} indicates an extraordinary JT distortion and significant anisotropic Mn–O bonding within the ab plane in the o-YMnO{sub 3} film. Most importantly, although the orbital occupation of 3d electrons in o-YMnO{sub 3} filmsmore » is almost the same as that in single crystalline o-DyMnO{sub 3}, the JT distortion of o-YMnO{sub 3} films is larger than that of single crystalline o-DyMnO{sub 3}, deduced from the multiplet calculations. We speculate that this JT distortion predominantly contributes to the origin of the cycloidal spin deformation in bulk o-YMnO{sub 3}, because of a suppressed nearest-neighbor superexchange interaction and an enhanced next-nearest-neighbor superexchange interaction. These complementary results provide insight into the origin of the E-type magnetic configuration of o-YMnO{sub 3}.« less

  14. Molecular genetics of syndromic and non-syndromic forms of parathyroid carcinoma.

    PubMed

    Cardoso, Luís; Stevenson, Mark; Thakker, Rajesh V

    2017-12-01

    Parathyroid carcinoma (PC) may occur as part of a complex hereditary syndrome or an isolated (i.e., non-syndromic) non-hereditary (i.e., sporadic) endocrinopathy. Studies of hereditary and syndromic forms of PC, which include the hyperparathyroidism-jaw tumor syndrome (HPT-JT), multiple endocrine neoplasia types 1 and 2 (MEN1 and MEN2), and familial isolated primary hyperparathyroidism (FIHP), have revealed some genetic mechanisms underlying PC. Thus, cell division cycle 73 (CDC73) germline mutations cause HPT-JT, and CDC73 mutations occur in 70% of sporadic PC, but in only ∼2% of parathyroid adenomas. Moreover, CDC73 germline mutations occur in 20%-40% of patients with sporadic PC and may reveal unrecognized HPT-JT. This indicates that CDC73 mutations are major driver mutations in the etiology of PCs. However, there is no genotype-phenotype correlation and some CDC73 mutations (e.g., c.679_680insAG) have been reported in patients with sporadic PC, HPT-JT, or FIHP. Other genes involved in sporadic PC include germline MEN1 and rearranged during transfection (RET) mutations and somatic alterations of the retinoblastoma 1 (RB1) and tumor protein P53 (TP53) genes, as well as epigenetic modifications including DNA methylation and histone modifications, and microRNA misregulation. This review summarizes the genetics and epigenetics of the familial syndromic and non-syndromic (sporadic) forms of PC. © 2017 The Authors. Human Mutation published by Wiley Periodicals, Inc.

  15. Characteristics of a liquid-helium-free calibration apparatus for cryogenic thermometers

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shimazaki, T.

    2013-09-11

    Closed-cycle Joule-Thomson (JT) cryocoolers have been developed at National Metrology Institute of Japan (NMIJ)/National Institute of Advanced Industrial Science and Technology (AIST) with the aim of realizing a liquid-helium-free calibration apparatus for cryogenic thermometers between 0.65 K and 25 K. The latest JT cryocooler at NMIJ/AIST consists of a {sup 3}He JT cooling circuit and a pulse tube mechanical refrigerator. The characteristics of the apparatus including a residual gas analysis of the JT cooling circuit are presented in this paper. Currently the initial cool-down is performed using a heat-exchange gas. It normally takes about 30 h to reduce the temperaturemore » from room temperature to 5 K at the thermometer comparison block of the apparatus. The correct timing of the removal of the heatexchange gas is important for the efficient operation of the apparatus. Incomplete removal of the heat-exchange gas induces excess heat load on the apparatus and thermal disturbances. Some examples of abrupt temperature bursts are discussed in this paper. Mechanical refrigerators generate cyclic mechanical vibrations, and precision resistance thermometers are usually very sensitive to a mechanical vibration. The measured vibration level of the developed apparatus is reported. The damage to the apparatus due to the magnitude 9.0 earthquake on March 11, 2011, and possible countermeasures in the case of future earthquakes are also discussed.« less

  16. Equilibrium Line Altitude fluctuations at HualcaHualca volcano (southern Peru).

    NASA Astrophysics Data System (ADS)

    Alcalá, Jesus; Palacios, David; Juan Zamorano, Jose

    2015-04-01

    Interest in Andean glaciers has substantially increased during the last decades, due to its high sensitivity to climate fluctuations. In this sense, Equilibrium Line Altitude (ELA) is a reliable indicator of climate variability that has been frequently used to reconstruct palaeoenvironmental conditions at different temporal and spatial scales. However, the number of sites with ELA reconstructions is still insufficient to determine patterns in tropical climate or estimations of atmospheric cooling since the Last Glacial Maximum. The main purpose of this study is to contribute in resolving tropical climate evolution through ELA calculations on HualcaHualca (15° 43' S; 71° 52' W; 6,025 masl), a large andesitic stratovolcano located in the south-western Peruvian Andes approximately 70 km north-west of Arequipa. We applied Terminus Headwall Altitude Ratio (THAR) with 0.2; 0.4; 0.5; 0.57 ratios, Accumulation Area Ratio (AAR) and Accumulation Area Balance Ratio (AABR) methods in four valleys of HualcaHualca volcano: Huayuray (north side), Pujro Huayjo (southwest side), Mollebaya (east side) and Mucurca (west side). To estimate ELA depression, we calculated the difference between the ELA on 1955 with its position in the Maximum Glacier Extent (MGE), Tardiglacial phases, little Ice Age (LIA) and 2000. Paleotemperature reconstructions derived from vertical temperature gradient 6.5° C / 1 km, based on GODDARD global observation system considered the most appropriate model for arid Andes. During MGE, the ELA was located between 5,005 (AABR) and 5,215 (AAR 0.67) masl. But in 1955, ELA rose to 5,685 (AABR) - 5,775 (AAR 0.67) masl. The ELA depression between those two phases is 560 - 680 m that implies a temperature decrease of 3.5° - 4.4° C. The experimental process based in the use and contrast of different ELA reconstruction techniques applied in this study suggests that THAR (0.57), AAR (0.67) or AABR are the most consistent procedures for HualcaHualca glaciers, while

  17. The Use of Cognitive Task Analysis and Simulators for After Action Review of Medical Events in Iraq

    DTIC Science & Technology

    2006-12-01

    research attempts to improve medical AAR with a novel combination of Cognitive Task Analysis conducted while interviewees moulage simulators (Clark and...hypothesized that our protocol which employed a novel combination of medical Cognitive Task Analysis combined with the moulage of instruments and depictions

  18. 76 FR 34802 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-14

    ... DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2005-21613... amending document dated May 3, 2011, the Association of American Railroads (AAR) has petitioned the Federal Railroad Administration (FRA) for a waiver of compliance from certain provisions of the Federal railroad...

  19. Prostate cell membrane chromatography-liquid chromatography-mass spectrometry for screening of active constituents from Uncaria rhynchophylla.

    PubMed

    He, Jianyu; Han, Shengli; Yang, Fangfang; Zhou, Nan; Wang, Sicen

    2013-01-01

    Uncaria rhynchophylla is a traditional Chinese medicinal herb used to treat hypertension and convulsive disorders such as epilepsy. Rat prostate cell membrane chromatography combined with liquid chromatography-mass spectrometry (LC-MS) was used to identify active constituents from U. rhynchophylla extracts. Four compounds (corynoxeine, isorhynchophylline, isocorynoxeine and rhynchophylline) were discovered. Competitive binding assay results indicated that the four compounds were in direct competition at a single common binding site and interacted with α1A adrenergic receptors (α1A-AR) in a manner similar to tamsulosin. Affinity constant values of the four compounds binding with α1A-AR were also measured using rat prostate cell membrane chromatography (CMC). Finally, their pharmacodynamic effects were tested on rat caudal arteries. This CMC combined LC-MS system offers a means of drug discovery by screening natural medicinal herbs for new pharmacologically active molecules targeting specific receptors.

  20. Nacelle Aerodynamic and Inertial Loads (NAIL) project. Appendix B

    NASA Technical Reports Server (NTRS)

    1981-01-01

    The testing was conducted on the Boeing-owned 747 RA001 test bed airplane during the concurrent 767/JT9D-7R4 engine development program. Following a functional check flight conducted from Boeing Field International (BFI) on 3 October 1980, the airplane and test personnel were ferried to Valley Industrial Park (GSG) near Glasgow, Montana, on 7 October 1980. The combined NAL and 7670JT9D-7R4 test flights were conducted at the Glasgow remote test site, and the airplane was returned to Seattle on 26 October 1980.

  1. Fluctuating pressures on fan blades of a turbofan engine: Static and wind-tunnel investigations

    NASA Technical Reports Server (NTRS)

    Schoenster, J. A.

    1982-01-01

    To investigate the fan noise generated from turbofan engines, miniature pressure transducers were used to measure the fluctuating pressure on the fan blades of a JT15D engine. Tests were conducted with the engine operating on an outdoor test stand and in a wind tunnel. It was found that a potential flow interaction between the fan blades and six, large support struts in the bypass duct is a dominant noise source in the JT15D engine. Effects of varying fan speed and the forward speed on the blade pressure are also presented.

  2. Study and development of acoustic treatment for jet engine tailpipes

    NASA Technical Reports Server (NTRS)

    Nelson, M. D.; Linscheid, L. L.; Dinwiddie, B. A., III; Hall, O. J., Jr.

    1971-01-01

    A study and development program was accomplished to attenuate turbine noise generated in the JT3D turbofan engine. Analytical studies were used to design an acoustic liner for the tailpipe. Engine ground tests defined the tailpipe environmental factors and laboratory tests were used to support the analytical studies. Furnace-brazed, stainless steel, perforated sheet acoustic liners were designed, fabricated, installed, and ground tested in the tailpipe of a JT3D engine. Test results showed the turbine tones were suppressed below the level of the jet exhaust for most far field polar angles.

  3. Outgas analysis of mechanical cryocoolers for long lifetime

    NASA Astrophysics Data System (ADS)

    Sato, Yoichi; Shinozaki, Keisuke; Sawada, Kenichiro; Sugita, Hiroyuki; Mitsuda, Kazuhisa; Yamasaki, Noriko Y.; Nakagawa, Takao; Tsunematsu, Shoji; Otsuka, Kiyomi; Kanao, Kenichi; Yoshida, Seiji; Narasaki, Katsuhiro

    2017-12-01

    Mechanical cryocoolers for space applications are required to have high reliability to achieve long-term operation in orbit. ASTRO-H (Hitomi), the 6th Japanese X-ray astronomy mission, has a major scientific instrument onboard-the Soft X-ray Spectrometer (SXS) with several 20K-class two-stage Stirling (2ST) coolers and a 4K-class Joule Thomson (JT) cooler, which must operate for 3 years to ensure the lifetime of liquid helium as a cryogen for cooling of its detectors [1,2]. Other astronomical missions such as SPICA [3,4], LiteBIRD [5], and Athena [6] also have top requirements for these mechanical cryocoolers, including a 1K-class JT cooler to be operated for more than 3-5 years with no cryogen system. The reliability and lifetime of mechanical cryocoolers are generally understood to depend on (1) mechanical wear of the piston seal and valve seal, and (2) He working gas contaminated by impurity outgases, mainly H2O and CO2 released from the materials in the components of the cryocoolers. The second factor could be critical relative to causing blockage in the JT heat exchanger plumbing and the JT orifice or resulting in blockage in the Stirling regenerator and thereby degrading its performance. Thus, reducing the potential for outgassing in the cryocooler design and fabrication process, and predicting the total amount of outgases in the cryocooler are very important to ensure cryocooler lifetime and cooling performance in orbit. This paper investigates the outgas analysis of the 2ST and the 1K/4K-JT coolers for achieving a long lifetime. First, gas analysis was conducted for the materials and components of the mechanical cryocoolers, focusing on non-metallic materials as impurity gas sources. Then gas analysis of the mechanical wear effect of the piston seal materials and linear ball bearings was investigated. Finally, outgassing from a fully assembled cryocooler was measured to evaluate whether the outgas reduction process works properly to meet the requirement

  4. Reconstruction and attributes of jets observed in center of mass energy = 200 GeV proton-proton and deuteron-gold collisions at STAR

    NASA Astrophysics Data System (ADS)

    Henry, Thomas William

    The STAR collaboration recorded s = 200 GeV per nucleon d+Au and p+p collision events during the year 2003 RHIC run. In the p+p and the d+Au data samples, it is possible to reconstruct jets and make comparisons between them. This dissertation describes the reconstructed jet sample from the p+p events, the measurements of the jet jT distribution which quantifies the shape of the jet perpendicular to the jet direction, the jet fragmentation function (z), which quantifies the fraction of jet momentum carried by the jet particles, and the width of the parton momentum broadening distribution (kT). This dissertation also describes the comparison of these results to the reconstructed jet sample from d+Au events. Measurements of jet jT and jet fragmentation from p+p, d+Au, and PYTHIA are compared. The z and jT distributions from p+p and also d+Au are found to be consistent with PYTHIA event simulation version 6.205. RMS(jT) equals 612+/-12+/-30 MeV/c for p+p, and RMS(jT) equals 630+/-13+/-30 MeV/c for d+Au. The p+p kT Gaussian sigma (width) equals 2.08+/-0.12+/-0.13 GeV/c. This width is consistent with PYTHIA, kT literature surveys, and other RHIC measurements. A limit on nuclear jT broadening in the Au nucleus is also obtained, showing that nuclear jT is consistent with zero to within 0.5 GeV/c. The present status of the RdAu measurement from jets is also described. The nuclear kT broadening, in particular, is a measurement which has been done at this energy for the first time at RHIC. These measurements, while interesting by themselves, also will contribute ultimately to the understanding of Au+Au collisions at RHIC, and the properties of the high-density matter which results from them.

  5. Aminoacyl-tRNA Synthetases, the Genetic Code, and the Evolutionary Process

    PubMed Central

    Woese, Carl R.; Olsen, Gary J.; Ibba, Michael; Söll, Dieter

    2000-01-01

    The aminoacyl-tRNA synthetases (AARSs) and their relationship to the genetic code are examined from the evolutionary perspective. Despite a loose correlation between codon assignments and AARS evolutionary relationships, the code is far too highly structured to have been ordered merely through the evolutionary wanderings of these enzymes. Nevertheless, the AARSs are very informative about the evolutionary process. Examination of the phylogenetic trees for each of the AARSs reveals the following. (i) Their evolutionary relationships mostly conform to established organismal phylogeny: a strong distinction exists between bacterial- and archaeal-type AARSs. (ii) Although the evolutionary profiles of the individual AARSs might be expected to be similar in general respects, they are not. It is argued that these differences in profiles reflect the stages in the evolutionary process when the taxonomic distributions of the individual AARSs became fixed, not the nature of the individual enzymes. (iii) Horizontal transfer of AARS genes between Bacteria and Archaea is asymmetric: transfer of archaeal AARSs to the Bacteria is more prevalent than the reverse, which is seen only for the “gemini group.” (iv) The most far-ranging transfers of AARS genes have tended to occur in the distant evolutionary past, before or during formation of the primary organismal domains. These findings are also used to refine the theory that at the evolutionary stage represented by the root of the universal phylogenetic tree, cells were far more primitive than their modern counterparts and thus exchanged genetic material in far less restricted ways, in effect evolving in a communal sense. PMID:10704480

  6. Galvanising the NHS to Adopt Innovation

    PubMed Central

    Parris, Stuart; Cochrane, Gavin; Marjanovic, Sonja; Ling, Tom; Chataway, Joanna

    2016-01-01

    Abstract The Department of Health and the Wellcome Trust, in co-operation with NHS England, asked RAND Europe to conduct a limited consultation with key stakeholders about the practicality of measures and incentives proposed as part of the NHS Accelerated Access Review (AAR), which aims to assess the pathways for the development, assessment, and adoption of innovative medicines and medical technology. Through a focused engagement exercise with key healthcare stakeholders this project explored the implications of selected interim AAR propositions and feasibility of implementation for key actors, in primary and secondary care as well as commissioners and academia. Specifically, the project investigated the feasibility of implementation of three specific propositions including: a new earmarked fund to encourage AHSNs and other key innovation actors to re-design systems to embrace innovation; mobilising the influence of clinical system leaders to champion change; and encouraging secondary care organisations to take on “innovation champion” roles linked to financial incentives and a new emphasis on accountable care organisations. Data was collected on the feasibility of the three AAR propositions from a workshop with AHSN CEOs and Commercial Directors and interviews with senior NHS staff in three AHSN regions (South West, University College London Partners, and North East, North Cumbria). The study concludes with reflections on the feasibility of each recommendation and identifies factors expected to facilitate or challenge their implementation, as well as considering the wider cross cutting issues that may influence the adoption and diffusion of innovation in the NHS. PMID:28083436

  7. Distinct Correlation Structure Supporting a Rate-Code for Sound Localization in the Owl’s Auditory Forebrain

    PubMed Central

    2017-01-01

    Abstract While a topographic map of auditory space exists in the vertebrate midbrain, it is absent in the forebrain. Yet, both brain regions are implicated in sound localization. The heterogeneous spatial tuning of adjacent sites in the forebrain compared to the midbrain reflects different underlying circuitries, which is expected to affect the correlation structure, i.e., signal (similarity of tuning) and noise (trial-by-trial variability) correlations. Recent studies have drawn attention to the impact of response correlations on the information readout from a neural population. We thus analyzed the correlation structure in midbrain and forebrain regions of the barn owl’s auditory system. Tetrodes were used to record in the midbrain and two forebrain regions, Field L and the downstream auditory arcopallium (AAr), in anesthetized owls. Nearby neurons in the midbrain showed high signal and noise correlations (RNCs), consistent with shared inputs. As previously reported, Field L was arranged in random clusters of similarly tuned neurons. Interestingly, AAr neurons displayed homogeneous monotonic azimuth tuning, while response variability of nearby neurons was significantly less correlated than the midbrain. Using a decoding approach, we demonstrate that low RNC in AAr restricts the potentially detrimental effect it can have on information, assuming a rate code proposed for mammalian sound localization. This study harnesses the power of correlation structure analysis to investigate the coding of auditory space. Our findings demonstrate distinct correlation structures in the auditory midbrain and forebrain, which would be beneficial for a rate-code framework for sound localization in the nontopographic forebrain representation of auditory space. PMID:28674698

  8. 78 FR 34427 - 2012 Tax Information for Use In The Revenue Shortfall Allocation Method

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-07

    ... Information for Use In The Revenue Shortfall Allocation Method AGENCY: Surface Transportation Board, DOT... of American Railroads (AAR), for use in the Revenue Shortfall Allocation Method (RSAM). DATES... revised in Simplified Standards for Rail Rate Cases--Taxes in Revenue Shortfall Allocation Method, EP 646...

  9. Results and analysis of the switchyard impact tests

    DOT National Transportation Integrated Search

    1980-01-01

    This report presents the results and analysis of series 3 through 7 and series 10 of the FRA/RPI/AAR Switchyard Impact Tests. The test results and analysis are used to evaluate the head shield and the shelf-E coupler as protective devices for hazardo...

  10. LACK OF EFFECT OF AGE AND ANTIOXIDANT DEPLETION ON RESPIRATORY RESPONSES TO CONCENTRATED AMBIENT PARTICULATES (CAPS) IN RATS

    EPA Science Inventory

    2003 AAR PM Meeting
    Particulate Matter: Atmospheric Sciences,
    Exposure and the Fourth Colloquium on PM and Human Health

    LACK OF EFFECT OF AGE AND ANTIOXIDANT DEPLETION ON RESPIRATORY RESPONSES TO CONCENTRATED AMBIENT PARTICULATES (CAPs) IN RATS. JA Dye, LC Walsh, C...

  11. Complementary Roles of Spark Range and Onboard Free-Flight Measurements for Projectile Development

    DTIC Science & Technology

    2009-08-01

    MET data adequate for aerodynamic analysis requires coordinating with local MET personnel for the release of balloons at strategic times and...TACOM ARDEC AMSRD AAR AEM C M CORZO A READDY R LEE J COSME BLDG 94 PICATINNY ARSENAL NJ 07806-5000 1 COMMANDER US

  12. 77 FR 76169 - Quarterly Rail Cost Adjustment Factor

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ....stb.dot.gov . Copies of the decision may be purchased by contacting the Office of Public Assistance...)] Quarterly Rail Cost Adjustment Factor AGENCY: Surface Transportation Board, DOT. ACTION: Approval of rail cost adjustment factor. SUMMARY: The Board has approved the AAR's proposed rebasing calculations and...

  13. Personal Epistemology of Urban Elementary School Teachers

    ERIC Educational Resources Information Center

    Pearrow, Melissa; Sanchez, William

    2008-01-01

    Personal epistemology, originating from social construction theory, provides a framework for researchers to understand how individuals view their world. The Attitudes About Reality (AAR) scale is one survey method that qualitatively assesses personal epistemology along the logical positivist and social constructionist continuum; however, the…

  14. 76 FR 7627 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-10

    .... Eighteen (18) separate groups of locomotives were identified for investigation in the waiver approval... groups that must be investigated. In support of this petition, AAR says that this extension will be... electronic air brake equipment. They have also submitted information from WRE supporting combining EPIC...

  15. Operating Modes and Cooling Capabilities of the Flight ADR for the SXS Instrument on Astro-H

    NASA Technical Reports Server (NTRS)

    Shirron, Peter; Kimball, Mark; DiPirro, Michael

    2015-01-01

    The microcalorimeter array on the Soft X-ray Spectrometer instrument on Astro-H requires cooling to 50 mK, which will be accomplished by a 3-stage adiabatic demagnetization refrigerator (ADR). The ADR is surrounded by a cryogenic system consisting of a superfluid helium tank, a 4.5 K Joule-Thomson (JT) cryocooler, and additional 2-stage Stirling cryocoolers that pre-cool the JT cooler and radiation shields within the cryostat. The unique ADR design allows the instrument to meet all of its science requirements using either the stored cryogen or the JT cryocooler as its heat sink, giving the instrument an unusual degree of tolerance for component failures or degradation in the cryogenic system. The flight detector assembly, ADR and dewar were integrated in early 2014, and have since been extensively characterized and calibrated. At present, the four instruments are being integrated with the spacecraft in preparation for an early 2016 launch. This presentation summarizes the operation and performance of the ADR in all of its operating modes.

  16. Study of turboprop systems reliability and maintenance costs

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The overall reliability and maintenance costs (R&MC's) of past and current turboprop systems were examined. Maintenance cost drivers were found to be scheduled overhaul (40%), lack of modularity particularly in the propeller and reduction gearbox, and lack of inherent durability (reliability) of some parts. Comparisons were made between the 501-D13/54H60 turboprop system and the widely used JT8D turbofan. It was found that the total maintenance cost per flight hour of the turboprop was 75% higher than that of the JT8D turbofan. Part of this difference was due to propeller and gearbox costs being higher than those of the fan and reverser, but most of the difference was in the engine core where the older technology turboprop core maintenance costs were nearly 70 percent higher than for the turbofan. The estimated maintenance cost of both the advanced turboprop and advanced turbofan were less than the JT8D. The conclusion was that an advanced turboprop and an advanced turbofan, using similar cores, will have very competitive maintenance costs per flight hour.

  17. Operating modes and cooling capabilities of the 3-stage ADR developed for the Soft-X-ray Spectrometer instrument on Astro-H

    NASA Astrophysics Data System (ADS)

    Shirron, Peter J.; Kimball, Mark O.; James, Bryan L.; Muench, Theodore; DiPirro, Michael J.; Letmate, Richard V.; Sampson, Michael A.; Bialas, Tom G.; Sneiderman, Gary A.; Porter, Frederick S.; Kelley, Richard L.

    2016-03-01

    A 3-stage adiabatic demagnetization refrigerator (ADR) (Shirron et al., 2012) is used on the Soft X-ray Spectrometer instrument (Mitsuda et al., 2010) on Astro-H (Takahashi et al., 2010) [3] to cool a 6 × 6 array of X-ray microcalorimeters to 50 mK. The ADR is supported by a cryogenic system (Fujimoto et al., 2010) consisting of a superfluid helium tank, a 4.5 K Joule-Thomson (JT) cryocooler, and additional 2-stage Stirling cryocoolers that pre-cool the JT cooler and cool radiation shields within the cryostat. The ADR is configured so that it can use either the liquid helium or the JT cryocooler as its heat sink, giving the instrument an unusual degree of tolerance for component failures or degradation in the cryogenic system. The flight detector assembly, ADR and dewar were integrated into the flight dewar in early 2014, and have since been extensively characterized and calibrated. This paper summarizes the operation and performance of the ADR in all of its operating modes.

  18. Towards a 20 kA high temperature superconductor current lead module using REBCO tapes

    NASA Astrophysics Data System (ADS)

    Heller, R.; Bagrets, N.; Fietz, W. H.; Gröner, F.; Kienzler, A.; Lange, C.; Wolf, M. J.

    2018-01-01

    Most of the large fusion devices presently under construction or in operation consisting of superconducting magnets like EAST, Wendelstein 7-X (W7-X), JT-60SA, and ITER, use high temperature superconductor (HTS) current leads (CL) to reduce the cryogenic load and operational cost. In all cases, the 1st generation HTS material Bi-2223 is used which is embedded in a low-conductivity matrix of AgAu. In the meantime, industry worldwide concentrates on the production of the 2nd generation HTS REBCO material because of the better field performance in particular at higher temperature. As the new material can only be produced in a multilayer thin-film structure rather than as a multi-filamentary tape, the technology developed for Bi-2223-based current leads cannot be transferred directly to REBCO. Therefore, several laboratories are presently investigating the design of high current HTS current leads made of REBCO. Karlsruhe Institute of Technology is developing a 20 kA HTS current lead using brass-stabilized REBCO tapes—as a further development to the Bi-2223 design used in the JT-60SA current leads. The same copper heat exchanger module as in the 20 kA JT-60SA current lead will be used for simplicity, which will allow a comparison of the newly developed REBCO CL with the earlier produced and investigated CL for JT-60SA. The present paper discusses the design and accompanying test of single tape and stack REBCO mock-ups. Finally, the fabrication of the HTS module using REBCO stacks is described.

  19. 49 CFR 179.100-10 - Postweld heat treatment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-10 Postweld heat... heat treated as a unit in compliance with the requirements of AAR Specifications for Tank Cars...

  20. 49 CFR 179.100-10 - Postweld heat treatment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-10 Postweld heat... heat treated as a unit in compliance with the requirements of AAR Specifications for Tank Cars...

  1. 49 CFR 179.100-10 - Postweld heat treatment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120) § 179.100-10 Postweld heat... heat treated as a unit in compliance with the requirements of AAR Specifications for Tank Cars...

  2. Use of Informal Networks to Resolve Logistics-related Issues in Humanitarian Assistance Disaster Response

    DTIC Science & Technology

    2011-06-01

    efforts and the situation objectively and were not tempted to cast themselves in a favorable light ( Podsakoff & Organ, 1986). The AARs and CDRs were...Management.13(3), 146-156. doi: 10.1108/ 13673270910962932. Podsakoff , P.M., & Organ, D.W. (1986). Self-Reports in Organizational Research: Problems

  3. Validation of Arabic and English versions of the ARSMA-II Acculturation Rating Scale.

    PubMed

    Jadalla, Ahlam; Lee, Jerry

    2015-02-01

    To translate and adapt the Acculturation Rating Scale of Mexican-Americans II (ARSMA-II) for Arab Americans. A multistage translation process followed by a pilot and a large study. The translated and adapted versions, Acculturation Rating Scale for Arabic Americans-II Arabic and English (ARSAA-IIA, ARSAA-IIE), were validated in a sample of 297 Arab Americans. Factor analyses with principal axis factoring extractions and direct oblimin rotations were used to identify the underlying structure of ARSAA-II. Factor analysis confirmed the underlying structure of ARSAA-II and produced two interpretable factors labeled as 'Attraction to American Culture' (AAmC) and 'Attraction to Arabic Culture' (AArC). The Cronbach's alphas of AAmC and AArC were .89 and .85 respectively. Findings support ARSAA-II A & E to assess acculturation among Arab Americans. The emergent factors of ARSAA-II support the theoretical structure of the original ARSMA-II tool and show high internal consistency.

  4. Direct dating of human fossils.

    PubMed

    Grün, Rainer

    2006-01-01

    The methods that can be used for the direct dating of human remains comprise of radiocarbon, U-series, electron spin resonance (ESR), and amino acid racemization (AAR). This review gives an introduction to these methods in the context of dating human bones and teeth. Recent advances in ultrafiltration techniques have expanded the dating range of radiocarbon. It now seems feasible to reliably date bones up to 55,000 years. New developments in laser ablation mass spectrometry permit the in situ analysis of U-series isotopes, thus providing a rapid and virtually non-destructive dating method back to about 300,000 years. This is of particular importance when used in conjunction with non-destructive ESR analysis. New approaches in AAR analysis may lead to a renaissance of this method. The potential and present limitations of these direct dating techniques are discussed for sites relevant to the reconstruction of modern human evolution, including Florisbad, Border Cave, Tabun, Skhul, Qafzeh, Vindija, Banyoles, and Lake Mungo. (c) 2006 Wiley-Liss, Inc.

  5. Improved components for engine fuel savings

    NASA Technical Reports Server (NTRS)

    Antl, R. J.; Mcaulay, J. E.

    1980-01-01

    NASA programs for developing fuel saving technology include the Engine Component Improvement Project for short term improvements in existing air engines. The Performance Improvement section is to define component technologies for improving fuel efficiency for CF6, JT9D and JT8D turbofan engines. Sixteen concepts were developed and nine were tested while four are already in use by airlines. If all sixteen concepts are successfully introduced the gain will be fuel savings of more than 6 billion gallons over the lifetime of the engines. The improvements include modifications in fans, mounts, exhaust nozzles, turbine clearance and turbine blades.

  6. Test-engine and inlet performance of an aircraft used for investigating flight effects on fan noise

    NASA Technical Reports Server (NTRS)

    Golub, R. A.; Preisser, J. S.

    1984-01-01

    As part of the NASA Flight Effects on Fan Noise Program, a Grumman OV-1B Mohawk aircraft was modified to carry a modified and instrumented Pratt & Whitney JT15D-1 turbofan engine. Onboard flight data, together with simultaneously measured farfield acoustic data, comprise a flight data base to which JT15D-1 static and wind-tunnel data are compared. The overall objective is to improve the ability to use ground-based facilities for the prediction of flight inlet radiated noise. This report describes the hardware and presents performance results for the research engine.

  7. An improved method for predicting the effects of flight on jet mixing noise

    NASA Technical Reports Server (NTRS)

    Stone, J. R.

    1979-01-01

    A method for predicting the effects of flight on jet mixing noise has been developed on the basis of the jet noise theory of Ffowcs-Williams (1963) and data derived from model-jet/free-jet simulated flight tests. Predicted and experimental values are compared for the J85 turbojet engine on the Bertin Aerotrain, the low-bypass refanned JT8D engine on a DC-9, and the high-bypass JT9D engine on a DC-10. Over the jet velocity range from 280 to 680 m/sec, the predictions show a standard deviation of 1.5 dB.

  8. Development of an Advanced Fan Blade Containment System

    DTIC Science & Technology

    1989-08-01

    TFE731 -2 4500 28.2 30 CFM56-2 24000 70.5 44 PW2037 38250 78.5 36 JT9D-7 45600 93.4 46 CF6-6D 45750 86.4 38 RB211-524D4 53000 86.3 33 JT9D-7R4G 54750 94.9...THRUST MODEL (LB) TIP IMPACT BAEIMPACT I MACT F109 1,330 3.172 2.158 0.854 TFE731 -5 4,500 4.455 3.019 0.983 CFM56-2 24,000 10.900 7.398 1.864 FIGURE 7

  9. 76 FR 40448 - 2010 Tax Information for Use in the Revenue Shortfall Allocation Method

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... Information for Use in the Revenue Shortfall Allocation Method AGENCY: Surface Transportation Board. ACTION... Railroads (AAR), for use in the Revenue Shortfall Allocation Method (RSAM). DATES: Comments are due by... Allocation Method, EP 646 (Sub-No. 2) (STB served Nov. 21, 2008). RSAM is intended to measure the average...

  10. 76 FR 35026 - Weather Shield Manufacturing, Inc. Corporate Office, Medford, WI; Notice of Amended Negative...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... subject firm's major declining customers regarding their purchases of doors and/or windows in the relevant period. AAR 29-48. The survey revealed that customer imports of articles like or directly competitive... customer list or any list of the customers to whom Labor issued questionnaires.'') The materials to which...

  11. 78 FR 7857 - Proposed Agency Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... below have been forwarded to the Office of Management and Budget (OMB) for review and comment. The ICRs... brand identification of the material. (3) Each individual unit of a glazing material that has...) the manufacturer of the material; (iii) the type or brand identification of the material. AAR believes...

  12. 49 CFR 179.300-10 - Postweld heat treatment.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-10 Postweld heat treatment... as a unit in compliance with the requirements of AAR Specifications for Tank Cars, appendix W (IBR...

  13. 49 CFR 179.100-12 - Manway nozzle, cover and protective housing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120... with the requirements of AAR Specifications for Tank Cars, appendix E, Figure E10 (IBR, see § 171.7 of...

  14. 49 CFR 179.100-12 - Manway nozzle, cover and protective housing.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120... with the requirements of AAR Specifications for Tank Cars, appendix E, Figure E10 (IBR, see § 171.7 of...

  15. 49 CFR 179.100-12 - Manway nozzle, cover and protective housing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120... with the requirements of AAR Specifications for Tank Cars, appendix E, Figure E10 (IBR, see § 171.7 of...

  16. 49 CFR 179.300-10 - Postweld heat treatment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-10 Postweld heat treatment... as a unit in compliance with the requirements of AAR Specifications for Tank Cars, appendix W (IBR...

  17. 49 CFR 179.100-12 - Manway nozzle, cover and protective housing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Pressure Tank Car Tanks (Classes DOT-105, 109, 112, 114 and 120... with the requirements of AAR Specifications for Tank Cars, appendix E, Figure E10 (IBR, see § 171.7 of...

  18. Operational Performance of the U.S. 28th Infantry Division September to December 1944

    DTIC Science & Technology

    1994-06-03

    Kansas. Hereafter referred to as V Corps, G-I AAR. 12. Ibid. 12. Charlie Waldrup, Voices From The Foxholes (Edited by Dorothy Chernitsky , Uniontown, PA...Foxholes. Edited by Dorothy Chernitsky (Uniontown, PA: Published by the Author, 1991), 233-234. 36. MacDonald and Mathews, Three.Battle, 344-345. 37

  19. 49 CFR 171.7 - Reference material.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Equipped Freight Car and Intermodal Equipment, 1988 174.55; 174.63. AAR Specifications for Design... Pamphlet C-8, Standard for Requalification of DOT-3HT Cylinder Design, 1985 180.205; 180.209. CGA Pamphlet C-11, Recommended Practices for Inspection of Compressed Gas Cylinders at Time of Manufacture, 2001...

  20. 49 CFR 171.7 - Reference material.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Car and Intermodal Equipment, 1988 174.55; 174.63. AAR Specifications for Design, Fabrication and... Pamphlet C-8, Standard for Requalification of DOT-3HT Cylinder Design, 1985 180.205; 180.209. CGA Pamphlet C-11, Recommended Practices for Inspection of Compressed Gas Cylinders at Time of Manufacture, 2001...

  1. Compression and Associated Properties of Boron Carbide

    DTIC Science & Technology

    2008-12-01

    of Brookhaven National Laboratory ( BNL ) with the light extracted from the x-ray source in a method previously described (Liu et al., 2002).. A...are sharper and more intense relative to as received material. ACKNOWLEDGMENTS Thanks are due to Dr. Jingzhu Hu and Dr. Zhenxian Liu of BNL

  2. Noninvasive Assessment of Liver Fibrosis Stage Using Ultrasound-Based Shear Wave Velocity Measurements and Serum Algorithms in Patients With Viral Hepatitis B: A Retrospective Cohort Study.

    PubMed

    Liu, Jianxue; Zhao, Junzhi; Zhang, Yaoren; Ji, Yonghao; Lin, Shumei; Dun, Guoliang; Guo, Sujuan

    2017-02-01

    Liver biopsy remains the reference standard for the assessment of liver fibrosis, but this procedure is invasive and can lead to complications. Thus, studies to determine the optimal noninvasive test are warranted. This study compared several noninvasive tests and their combinations for evaluating liver fibrosis stages in patients with chronic hepatitis B. The shear wave velocity (SWV) and laboratory indicators were collected from 174 patients with chronic hepatitis B. Formulas were applied to calculate the serum fibrosis model, including the aspartate aminotransaminase-to-platelet ratio index (APRI), fibrosis-4 index (FIB-4) and aspartate aminotransferase-to-alanine aminotransferase ratio (AAR). The diagnostic performance of all noninvasive tests was assessed in comparison with percutaneous liver biopsy, based on a receiver operating characteristic curve analysis. The SWV (area under the receiver operating characteristic curve [AUC], 0.82) and APRI (AUC = 0.77) performed better than the FIB-4 (AUC = 0.62), and the AAR (AUC = 0.47) was not suitable for evaluating substantial liver fibrosis (stage ≥F2). The SWV (AUC = 0.96) was the best indicator, being superior to the APRI (AUC = 0.75) and FIB-4 (AUC = 0.74), and the AAR (AUC = 0.45) was not suitable for assessing cirrhosis (F4). Combining the SWV and APRI, the AUC improved to 0.85 for substantial liver fibrosis, and the sensitivity increased to 100% for cirrhosis. The SWV, APRI, and FIB-4 were valid tests for evaluating substantial liver fibrosis and cirrhosis. The combination of these tests with several noninvasive indicators is expected to enhance the assessment of liver fibrosis stages. © 2016 by the American Institute of Ultrasound in Medicine.

  3. Command Center Training Tool (C2T2)

    NASA Technical Reports Server (NTRS)

    Jones, Phillip; Drucker, Nich; Mathews, Reejo; Stanton, Laura; Merkle, Ed

    2012-01-01

    This abstract presents the training approach taken to create a management-centered, experiential learning solution for the Virginia Port Authority's Port Command Center. The resultant tool, called the Command Center Training Tool (C2T2), follows a holistic approach integrated across the training management cycle and within a single environment. The approach allows a single training manager to progress from training design through execution and AAR. The approach starts with modeling the training organization, identifying the organizational elements and their individual and collective performance requirements, including organizational-specific performance scoring ontologies. Next, the developer specifies conditions, the problems, and constructs that compose exercises and drive experiential learning. These conditions are defined by incidents, which denote a single, multi-media datum, and scenarios, which are stories told by incidents. To these layered, modular components, previously developed meta-data is attached, including associated performance requirements. The components are then stored in a searchable library An event developer can create a training event by searching the library based on metadata and then selecting and loading the resultant modular pieces. This loading process brings into the training event all the previously associated task and teamwork material as well as AAR preparation materials. The approach includes tools within an integrated management environment that places these materials at the fingertips of the event facilitator such that, in real time, the facilitator can track training audience performance and resultantly modify the training event. The approach also supports the concentrated knowledge management requirements for rapid preparation of an extensive AAR. This approach supports the integrated training cycle and allows a management-based perspective and advanced tools, through which a complex, thorough training event can be developed.

  4. Overview of overseas humanitarian, disaster, and civic aid programs.

    PubMed

    Drifmeyer, Jeff; Llewellyn, Craig

    2003-12-01

    The U.S. Department of Defense (DoD) conducts humanitarian assistance missions under the Overseas Humanitarian Disaster and Civic Aid program for the statutory purposes of training military personnel, serving the political interests of the host nation and United States, and providing humanitarian relief to foreign civilians. These purposes are undertaken via the humanitarian assistance (HA), humanitarian and civic assistance, and excess property donation programs. DoD conducts over 200 such projects annually at a direct cost of approximately 27 million dollars in fiscal year 2001. Although varying by year and command, as many as one-half of these projects involve aspects of health care. These range from short-term patient care to donation of medical supplies and equipment excess to the needs of the DoD. Despite the considerable resources invested and importance of international actions, there is presently no formal evaluation system for these HA projects. Current administrative staffing of these programs by military personnel is often by individuals with many other duties and responsibilities. As a result, humanitarian projects are often inadequately coordinated with nongovernmental organizations, private volunteer organizations, or host-nation officials. Nonmedical military personnel sometimes plan health-related projects with little or no coordination with medical experts, military or civilian. After action reports (AARs) on these humanitarian projects are often subjective, lack quantitative details, and are devoid of measures of effectiveness. AARs are sometimes inconsistently completed, and there is no central repository of information for analysis of lessons learned. (The approximate 100 AARs used in the conduct of these studies are available for official use in the Learning Resources Center, Uniformed Services University of Health Sciences.) Feedback from past humanitarian projects is rare and with few exceptions; DoD-centric projects of a similar design are

  5. Quantification of both the area-at-risk and acute myocardial infarct size in ST-segment elevation myocardial infarction using T1-mapping.

    PubMed

    Bulluck, Heerajnarain; Hammond-Haley, Matthew; Fontana, Marianna; Knight, Daniel S; Sirker, Alex; Herrey, Anna S; Manisty, Charlotte; Kellman, Peter; Moon, James C; Hausenloy, Derek J

    2017-08-01

    A comprehensive cardiovascular magnetic resonance (CMR) in reperfused ST-segment myocardial infarction (STEMI) patients can be challenging to perform and can be time-consuming. We aimed to investigate whether native T1-mapping can accurately delineate the edema-based area-at-risk (AAR) and post-contrast T1-mapping and synthetic late gadolinium (LGE) images can quantify MI size at 1.5 T. Conventional LGE imaging and T2-mapping could then be omitted, thereby shortening the scan duration. Twenty-eight STEMI patients underwent a CMR scan at 1.5 T, 3 ± 1 days following primary percutaneous coronary intervention. The AAR was quantified using both native T1 and T2-mapping. MI size was quantified using conventional LGE, post-contrast T1-mapping and synthetic magnitude-reconstructed inversion recovery (MagIR) LGE and synthetic phase-sensitive inversion recovery (PSIR) LGE, derived from the post-contrast T1 maps. Native T1-mapping performed as well as T2-mapping in delineating the AAR (41.6 ± 11.9% of the left ventricle [% LV] versus 41.7 ± 12.2% LV, P = 0.72; R 2 0.97; ICC 0.986 (0.969-0.993); bias -0.1 ± 4.2% LV). There were excellent correlation and inter-method agreement with no bias, between MI size by conventional LGE, synthetic MagIR LGE (bias 0.2 ± 2.2%LV, P = 0.35), synthetic PSIR LGE (bias 0.4 ± 2.2% LV, P = 0.060) and post-contrast T1-mapping (bias 0.3 ± 1.8% LV, P = 0.10). The mean scan duration was 58 ± 4 min. Not performing T2 mapping (6 ± 1 min) and conventional LGE (10 ± 1 min) would shorten the CMR study by 15-20 min. T1-mapping can accurately quantify both the edema-based AAR (using native T1 maps) and acute MI size (using post-contrast T1 maps) in STEMI patients without major cardiovascular risk factors. This approach would shorten the duration of a comprehensive CMR study without significantly compromising on data acquisition and would obviate the need to perform T2 maps and LGE imaging.

  6. Effects of Synephrine and B-Phenethylamine on Human a-Adrenoceptor Subtypes

    USDA-ARS?s Scientific Manuscript database

    Synephrine and B-phenethylamine are structurally related to ephedrine. In this study, the effects of synephrine and B-phenethylamine are investigated on a-adrenoceptor (a-AR) subtypes expressed in human embroyonic kidney (HEK293) or Chinese hamster ovary (CHO) cells, and compared to that of 1R,2S-no...

  7. 49 CFR 179.200-13 - Manway ring or flange, pressure relief device flange, bottom outlet nozzle flange, bottom washout...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179..., figure 10, of the AAR Specifications for Tank Cars (IBR, see § 171.7 of this subchapter). (b) The opening...

  8. 49 CFR 179.200-13 - Manway ring or flange, pressure relief device flange, bottom outlet nozzle flange, bottom washout...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179..., figure 10, of the AAR Specifications for Tank Cars (IBR, see § 171.7 of this subchapter). (b) The opening...

  9. 49 CFR 179.200-13 - Manway ring or flange, pressure relief device flange, bottom outlet nozzle flange, bottom washout...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179..., figure 10, of the AAR Specifications for Tank Cars (IBR, see § 171.7 of this subchapter). (b) The opening...

  10. 49 CFR 179.200-11 - Postweld heat treatment.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-11 Postweld heat treatment... with the requirements of AAR Specifications for Tank Cars, appendix W (IBR, see § 171.7 of this...

  11. 49 CFR 179.200-13 - Manway ring or flange, pressure relief device flange, bottom outlet nozzle flange, bottom washout...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179..., figure 10, of the AAR Specifications for Tank Cars (IBR, see § 171.7 of this subchapter). (b) The opening...

  12. 49 CFR 179.220-11 - Postweld heat treatment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.220-11 Postweld heat treatment... attached must comply with AAR Specifications for Tank Cars, appendix W (IBR, see § 171.7 of this subchapter...

  13. 49 CFR 179.200-11 - Postweld heat treatment.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-11 Postweld heat treatment... with the requirements of AAR Specifications for Tank Cars, appendix W (IBR, see § 171.7 of this...

  14. 49 CFR 179.200-11 - Postweld heat treatment.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.200-11 Postweld heat treatment... with the requirements of AAR Specifications for Tank Cars, appendix W (IBR, see § 171.7 of this...

  15. 49 CFR 179.201-6 - Manways and manway closures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SPECIFICATIONS FOR TANK CARS Specifications for Non-Pressure Tank Car Tanks (Classes DOT-111AW and 115AW) § 179.201-6... in AAR Specifications for Tank Cars, appendix M, M3.03 (IBR, see § 171.7 of this subchapter). [Amdt...

  16. 49 CFR 179.4 - Changes in specifications for tank cars.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Changes in specifications for tank cars. 179.4... TANK CARS Introduction, Approvals and Reports § 179.4 Changes in specifications for tank cars. (a...—Tank Car Safety, AAR, for consideration by its Tank Car Committee. An application for construction of...

  17. 78 FR 51078 - Reporting Requirements for Positive Train Control Expenses and Investments

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-20

    ... useful in making regulatory policy and business decisions. The new rule will require a PTC Supplement \\5... interested parties with data useful in making regulatory policy and business decisions. PTC grants. AAR and... useful in regulatory decision making.\\45\\ They also argue that the burden will be on the carriers to...

  18. 49 CFR 179.102-4 - Vinyl fluoride, stabilized.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) Include impact specimens of weld metal and heat affected zone prepared and tested in accordance with AAR.... (b) Insulation must be of approved material. (c) Excess flow valves must be installed under all... capacity stencil, MINIMUM OPERATING TEMPERATURE _ °F. (i) The tank car and insulation must be designed to...

  19. Multimode Jahn-Teller effect in bulk systems: A case of the N V 0 center in diamond

    DOE PAGES

    Zhang, Jianhua; Wang, Cai -Zhuang; Zhu, Zizhong; ...

    2018-04-15

    Here, the multimode Jahn-Teller (JT) effect in a bulk system of a neutral nitrogen-vacancy (NV 0) center in diamond is investigated via first-principles density-functional-theory calculations and the intrinsic distortion path (IDP) method. The adiabatic potential energy surface of the electronic ground state of the NV 0 center is calculated based on the local spin-density approximation. Our calculations confirm the presence of the dynamic Jahn-Teller effect in the ground 2E state of the NV 0 center. Within the harmonic approximation, the IDP method provides the reactive path of JT distortion from unstable high-symmetry geometry to stable low-symmetry energy minimum geometry, andmore » it describes the active normal modes participating in the distortion. We find that there is more than one vibrational mode contributing to the distortion, and their contributions change along the IDP. Several vibrational modes with large contributions to JT distortion, especially those modes close to 44 meV, are clearly observed as the phonon sideband in photoluminescence spectra in a series of experiments, indicating that the dynamic Jahn-Teller effect plays an important role in the optical transition of the NV 0 center.« less

  20. Multimode Jahn-Teller effect in bulk systems: A case of the N V0 center in diamond

    NASA Astrophysics Data System (ADS)

    Zhang, Jianhua; Wang, Cai-Zhuang; Zhu, Zizhong; Liu, Qing Huo; Ho, Kai-Ming

    2018-04-01

    The multimode Jahn-Teller (JT) effect in a bulk system of a neutral nitrogen-vacancy (N V0 ) center in diamond is investigated via first-principles density-functional-theory calculations and the intrinsic distortion path (IDP) method. The adiabatic potential energy surface of the electronic ground state of the N V0 center is calculated based on the local spin-density approximation. Our calculations confirm the presence of the dynamic Jahn-Teller effect in the ground 2E state of the N V0 center. Within the harmonic approximation, the IDP method provides the reactive path of JT distortion from unstable high-symmetry geometry to stable low-symmetry energy minimum geometry, and it describes the active normal modes participating in the distortion. We find that there is more than one vibrational mode contributing to the distortion, and their contributions change along the IDP. Several vibrational modes with large contributions to JT distortion, especially those modes close to 44 meV, are clearly observed as the phonon sideband in photoluminescence spectra in a series of experiments, indicating that the dynamic Jahn-Teller effect plays an important role in the optical transition of the N V0 center.

  1. Multimode Jahn-Teller effect in bulk systems: A case of the N V 0 center in diamond

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Jianhua; Wang, Cai -Zhuang; Zhu, Zizhong

    Here, the multimode Jahn-Teller (JT) effect in a bulk system of a neutral nitrogen-vacancy (NV 0) center in diamond is investigated via first-principles density-functional-theory calculations and the intrinsic distortion path (IDP) method. The adiabatic potential energy surface of the electronic ground state of the NV 0 center is calculated based on the local spin-density approximation. Our calculations confirm the presence of the dynamic Jahn-Teller effect in the ground 2E state of the NV 0 center. Within the harmonic approximation, the IDP method provides the reactive path of JT distortion from unstable high-symmetry geometry to stable low-symmetry energy minimum geometry, andmore » it describes the active normal modes participating in the distortion. We find that there is more than one vibrational mode contributing to the distortion, and their contributions change along the IDP. Several vibrational modes with large contributions to JT distortion, especially those modes close to 44 meV, are clearly observed as the phonon sideband in photoluminescence spectra in a series of experiments, indicating that the dynamic Jahn-Teller effect plays an important role in the optical transition of the NV 0 center.« less

  2. Hot isostatically pressed manufacture of high strength MERL 76 disk and seal shapes

    NASA Technical Reports Server (NTRS)

    Eng, R. D.; Evans, D. J.

    1982-01-01

    The feasibility of using MERL 76, an advanced high strength direct hot isostatic pressed powder metallurgy superalloy, as a full scale component in a high technology, long life, commercial turbine engine were demonstrated. The component was a JT9D first stage turbine disk. The JT9D disk rim temperature capability was increased by at least 22 C and the weight of JT9D high pressure turbine rotating components was reduced by at least 35 pounds by replacement of forged Superwaspaloy components with hot isostatic pressed (HIP) MERL 76 components. The process control plan and acceptance criteria for manufacture of MERL 76 HIP consolidated components were generated. Disk components were manufactured for spin/burst rig test, experimental engine tests, and design data generation, which established lower design properties including tensile, stress-rupture, 0.2% creep and notched (Kt = 2.5) low cycle fatigue properties, Sonntag, fatigue crack propagation, and low cycle fatigue crack threshold data. Direct HIP MERL 76, when compared to conventionally forged Superwaspaloy, is demonstrated to be superior in mechanical properties, increased rim temperature capability, reduced component weight, and reduced material cost by at least 30% based on 1980 costs.

  3. Improving Control in a Joule-Thomson Refrigerator

    NASA Technical Reports Server (NTRS)

    Borders, James; Pearson, David; Prina, Mauro

    2005-01-01

    A report discusses a modified design of a Joule-Thomson (JT) refrigerator under development to be incorporated into scientific instrumentation aboard a spacecraft. In most other JT refrigerators (including common household refrigerators), the temperature of the evaporator (the cold stage) is kept within a desired narrow range by turning a compressor on and off as needed. This mode of control is inadequate for the present refrigerator because a JT-refrigerator compressor performs poorly when the flow from its evaporator varies substantially, and this refrigerator is required to maintain adequate cooling power. The proposed design modifications include changes in the arrangement of heat exchangers, addition of a clamp that would afford a controlled heat leak from a warmer to a cooler stage to smooth out temperature fluctuations in the cooler stage, and incorporation of a proportional + integral + derivative (PID) control system that would regulate the heat leak to maintain the temperature of the evaporator within a desired narrow range while keeping the amount of liquid in the evaporator within a very narrow range in order to optimize the performance of the compressor. Novelty lies in combining the temperature- and cooling-power-regulating controls into a single control system.

  4. Test results of a 20 kA high temperature superconductor current lead using REBCO tapes

    NASA Astrophysics Data System (ADS)

    Heller, R.; Fietz, W. H.; Gröner, F.; Heiduk, M.; Hollik, M.; Lange, C.; Lietzow, R.

    2018-05-01

    The Karlsruhe Institute of Technology has developed a 20 kA high temperature superconductor (HTS) current lead (CL) using the second generation material REBCO, as industry worldwide concentrate on the production of this material. The aim was to demonstrate the possibility of replacing the Bi-2223/AgAu tapes by REBCO tapes, while for easy comparison of results, all other components are copies of the 20 kA HTS CL manufactured for the satellite tokamak JT-60SA. After the manufacture of all CL components including the newly developed REBCO module, the assembly of the CL has been executed at KIT and an experiment has been carried out in the CuLTKa test facility where the REBCO CL was installed and connected to a JT-60SA CL via a superconducting bus bar. The experiment covers steady state operation up to 20 kA, pulsed operation, measurement of the heat load at 4.5 K end, loss-of-flow-accident simulations, and quench performance studies. Here the results of these tests are reported and directly compared to those of the JT-60SA CL.

  5. Theoretical study of orbital ordering induced structural phase transition in iron pnictides

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jena, Sushree Sangita, E-mail: sushree@iopb.res.in; Rout, G. C., E-mail: gcr@iopb.res.in; Panda, S. K., E-mail: skp@iopb.res.in

    2016-05-06

    We attribute the structural phase transition (SPT) in the parent compounds of the iron pnictides to orbital ordering. Due to anisotropy of the d{sub xz} and d{sub yz} orbitals in the xy plane, orbital ordering makes the orthorhombic structure more favorable and thus inducing the SPT. We consider a one band model Hamiltonian consisting of first and second-nearest-neighbor hopping of the electrons. We introduce Jahn-Tellar (JT) distortion in the system arising due to the orbital ordering present in this system. We calculate the electron Green’s function by using Zuvareb’s Green’s function technique and hence calculate an expression for the temperaturemore » dependent lattice strain which is computed numerically and self-consistently. The temperature dependent electron specific heat is calculated by minimizing the free energy of the system. The lattice strain is studied by varying the JT coupling and elastic constant of the system. The structural anomaly is studied through the electron occupation number and the specific heat by varying the physical parameters like JT coupling, lattice constant, chemical potential and hopping integrals of the system.« less

  6. 100 s extraction of negative ion beams by using actively temperature-controlled plasma grid

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kojima, A., E-mail: kojima.atsushi@jaea.go.jp; Hanada, M.; Yoshida, M.

    2014-02-15

    Long pulse beam extraction with a current density of 120 A/m{sup 2} for 100 s has been achieved with a newly developed plasma grid (PG) for the JT-60SA negative ion source which is designed to produce high power and long pulse beams with a negative ion current of 130 A/m{sup 2} (22 A) and a pulse length of 100 s. The PG temperature is regulated by fluorinated fluids in order to keep the high PG temperature for the cesium-seeded negative ion production. The time constant for temperature controllability of the PG was measured to be below 10 s, which wasmore » mainly determined by the heat transfer coefficient of the fluorinated fluid. The measured decay time of the negative ion current extracted from the actively temperature-controlled PG was 430 s which was sufficient for the JT-60SA requirement, and much longer than that by inertial-cooling PG of 60 s. Obtained results of the long pulse capability are utilized to design the full size PG for the JT-60SA negative ion source.« less

  7. AAR in concrete of Asejire spillway (OYO state - Nigeria)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lamaudiere, J.P.; Spaeti, F.

    1995-12-31

    The Asejire dam at Ibadan, Nigeria was constructed in the late sixties for the purpose of providing water for the city of Ibadan (presently about 4,5 million inhabitants). It is located on the Oshun river approximately fifteen miles from the city. In 1982 cracks were observed on the wing walls and although these continued to develop, no attempt was made at that time to investigate their causes and no repair was carried out. In 1989 the SGI ENGINEERING Group of Geneva, Switzerland was appointed as the consultant for the complete refurbishment of the Asejire water scheme. The consortium Degremont-Poat-Clemessy wasmore » awarded the contract for the project. The African Development Bank and the Nigerian Government have provided the loan to finance the project.« less

  8. Word Frequency Analysis. MOS: 62E. Skill Levels 1 & 2.

    DTIC Science & Technology

    1981-05-01

    j., JtU I J ’I JT S EiM. ’J~VERSA. 5 *J (Jtl~iL I ’JSJP 1 J LUSE t J &USED 5 1 .3 u51’G 3 J .3 UTZLI ATEICN 2 J & VALVE 1 0 J3 EVISUAL I .3 fVj5JLY 2...ECOVERY I 7TI;1Irk 9 REVI1VE I RECTLY 2 PEO 4 i:’ 1 R.EC13CED ? Rr.~vl I IlFr~k 44 RcFFZ(E: ; I Ff ," TF1 ’. I 1 !E* ST EPS 4 1 RELL..SSD 7 PkLIF I RELI~E t

  9. Dynamic PID loop control

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pei, L.; Klebaner, A.; Theilacker, J.

    2011-06-01

    The Horizontal Test Stand (HTS) SRF Cavity and Cryomodule 1 (CM1) of eight 9-cell, 1.3GHz SRF cavities are operating at Fermilab. For the cryogenic control system, how to hold liquid level constant in the cryostat by regulation of its Joule-Thompson JT-valve is very important after cryostat cool down to 2.0 K. The 72-cell cryostat liquid level response generally takes a long time delay after regulating its JT-valve; therefore, typical PID control loop should result in some cryostat parameter oscillations. This paper presents a type of PID parameter self-optimal and Time-Delay control method used to reduce cryogenic system parameters oscillation.

  10. Towards a bulk description of higher spin SYK

    NASA Astrophysics Data System (ADS)

    González, Hernán A.; Grumiller, Daniel; Salzer, Jakob

    2018-05-01

    We consider on the bulk side extensions of the Sachdev-Ye-Kitaev (SYK) model to Yang-Mills and higher spins. To this end we study generalizations of the Jackiw-Teitelboim (JT) model in the BF formulation. Our main goal is to obtain generalizations of the Schwarzian action, which we achieve in two ways: by considering the on-shell action supplemented by suitable boundary terms compatible with all symmetries, and by applying the Lee-Wald-Zoupas formalism to analyze the symplectic structure of dilaton gravity. We conclude with a discussion of the entropy (including log-corrections from higher spins) and a holographic dictionary for the generalized SYK/JT correspondence.

  11. Acoustic Properties of Crystals with Jahn-Teller Impurities: Elastic Moduli and Relaxation Time. Application to SrF2:Cr2+

    NASA Astrophysics Data System (ADS)

    Averkiev, Nikita S.; Bersuker, Isaac B.; Gudkov, Vladimir V.; Zhevstovskikh, Irina V.; Sarychev, Maksim N.; Zherlitsyn, Sergei; Yasin, Shadi; Shakurov, Gilman S.; Ulanov, Vladimir A.; Surikov, Vladimir T.

    2017-11-01

    A new approach to evaluate the relaxation contribution to the total elastic moduli for crystals with Jahn-Teller (JT) impurities is worked out and applied to the analysis of the experimentally measured ultrasound velocity and attenuation in SrF2:Cr2+. Distinguished from previous work, the background adiabatic contribution to the moduli, important for revealing the impurity relaxation contribution, is taken into account. The temperature dependence of the relaxation time for transitions between the equivalent configurations of the JT centers has been obtained, and the activation energy for the latter in SrF2:Cr2+, as well as the linear vibronic coupling constant have been evaluated.

  12. 49 CFR 232.307 - Modification of the single car air brake test procedures.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 4 2014-10-01 2014-10-01 false Modification of the single car air brake test... Requirements § 232.307 Modification of the single car air brake test procedures. (a) Request. The AAR or other authorized representative of the railroad industry may seek modification of the single car air brake test...

  13. 49 CFR 232.307 - Modification of the single car air brake test procedures.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 4 2013-10-01 2013-10-01 false Modification of the single car air brake test... Requirements § 232.307 Modification of the single car air brake test procedures. (a) Request. The AAR or other authorized representative of the railroad industry may seek modification of the single car air brake test...

  14. 49 CFR 179.102-4 - Vinyl fluoride, stabilized.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... weld metal and heat affected zone prepared and tested in accordance with AAR Specifications for Tank...) Insulation must be of approved material. (c) Excess flow valves must be installed under all liquid and vapor... OPERATING TEMPERATURE _ °F. (i) The tank car and insulation must be designed to prevent the vapor pressure...

  15. 49 CFR 179.102-4 - Vinyl fluoride, stabilized.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... weld metal and heat affected zone prepared and tested in accordance with AAR Specifications for Tank...) Insulation must be of approved material. (c) Excess flow valves must be installed under all liquid and vapor... OPERATING TEMPERATURE _ °F. (i) The tank car and insulation must be designed to prevent the vapor pressure...

  16. 49 CFR 179.102-4 - Vinyl fluoride, stabilized.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... weld metal and heat affected zone prepared and tested in accordance with AAR Specifications for Tank...) Insulation must be of approved material. (c) Excess flow valves must be installed under all liquid and vapor... OPERATING TEMPERATURE _ °F. (i) The tank car and insulation must be designed to prevent the vapor pressure...

  17. 49 CFR 179.102-4 - Vinyl fluoride, stabilized.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... weld metal and heat affected zone prepared and tested in accordance with AAR Specifications for Tank...) Insulation must be of approved material. (c) Excess flow valves must be installed under all liquid and vapor... OPERATING TEMPERATURE _ °F. (i) The tank car and insulation must be designed to prevent the vapor pressure...

  18. 77 FR 42704 - 36(b)(1) Arms Sales Notification

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... Vision Sensors, 12 AN/APG-78 Fire Control Radars (FCR) with Radar Electronics Unit (LONGBOW component... Target Acquisition and Designation Sight, 27 AN/AAR-11 Modernized Pilot Night Vision Sensors, 12 AN/APG... enhance the protection of key oil and gas infrastructure and platforms which are vital to U.S. and western...

  19. A New Key to Scholarly Collaboration?

    ERIC Educational Resources Information Center

    Fitzmier, Jack

    2012-01-01

    The American Academy of Religion, in concert with the Sakai Foundation, has envisioned a scholarly use of the new Sakai Open Academic Environment open-source software. Currently working under the title "Biosphere," the program would put a rich collection of collaborative tools in the hands of AAR members, their colleagues in related scholarly…

  20. 49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural design and...; metal IBCs and non-specification portable tanks equivalent in structural design and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...

  1. 49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural design and...; metal IBCs and non-specification portable tanks equivalent in structural design and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...

  2. 49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural design and...; metal IBCs and non-specification portable tanks equivalent in structural design and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...

  3. 49 CFR 173.247 - Bulk packaging for certain elevated temperature materials.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... motor vehicles; and non-DOT specification cargo tank motor vehicles equivalent in structural design and...; metal IBCs and non-specification portable tanks equivalent in structural design and accident damage...; Class DOT 106, 110 multi-unit tank car tanks; AAR Class 203W, 206W, 211W tank car tanks; and non-DOT...

  4. 49 CFR 232.307 - Modification of the single car air brake test procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Requirements § 232.307 Modification of the single car air brake test procedures. (a) Request. The AAR or other authorized representative of the railroad industry may seek modification of the single car air brake test... 49 Transportation 4 2010-10-01 2010-10-01 false Modification of the single car air brake test...

  5. 49 CFR 232.307 - Modification of the single car air brake test procedures.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Requirements § 232.307 Modification of the single car air brake test procedures. (a) Request. The AAR or other authorized representative of the railroad industry may seek modification of the single car air brake test... 49 Transportation 4 2011-10-01 2011-10-01 false Modification of the single car air brake test...

  6. 49 CFR 232.307 - Modification of the single car air brake test procedures.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Requirements § 232.307 Modification of the single car air brake test procedures. (a) Request. The AAR or other authorized representative of the railroad industry may seek modification of the single car air brake test... 49 Transportation 4 2012-10-01 2012-10-01 false Modification of the single car air brake test...

  7. 49 CFR 179.220-6 - Thickness of plates.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... heads; P = Minimum required bursting pressure in psig; S = Minimum tensile strength of plate material in p.s.i. as prescribed in AAR Specifications for Tank Cars, appendix M, Table M1; t = Minimum... seamless heads; L = Main inside radius to which head is dished, measured on concave side in inches; P...

  8. 78 FR 47824 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... DEPARTMENT OF TRANSPORTATION Federal Railroad Administration [Docket Number FRA-2013-0077] Petition for Waiver of Compliance In accordance with Part 211 of Title 49 Code of Federal Regulations (CFR), this document provides the public notice that by a document dated July 16, 2013, the Association of American Railroads (AAR) has petitioned the...

  9. 78 FR 46680 - Petition for Waiver of Compliance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-01

    ...] Petition for Waiver of Compliance In accordance with Part 211 of Title 49 Code of Federal Regulations (CFR... Administration (FRA) for a waiver of compliance from certain provisions of the Federal railroad safety.... Specifically, AAR seeks a waiver of compliance from Part 232, Appendix B, Part 232 Prior to May 31, 2001 as...

  10. Buyid Silk and the Tale of Bibi Shahrbanu: Identification of Biomarkers of Artificial Aging (Forgery) of Silk.

    PubMed

    Moini, Mehdi; Rollman, Christopher M

    2017-10-03

    Buyid silk forgery is one of the most famous silk forgeries in the world. In 1924-1925, excavation of the Bibi Shahrbanu site in Iran unearthed several silk textiles. The silks were thought to be of the Buyid period (934-1062 BCE) of the Persian Empire and have since been known as the "Buyid silks". In the 1930s, more silk appeared and was reported as being from the Buyid period as well. Controversy over the authenticity of these silks escalated after the purchase of the silks by museums throughout the world. Extensive investigations of several of these silks have been conducted over the years with respect to iconography, weaving patterns, dyes/mordant, style, and even radiocarbon dating. It was found that most of the silks are not from Buyid period. To test the authenticity of these silk fabrics, the recently developed silk dating technique using amino acid racemization (AAR) in conjunction with capillary electrophoresis mass spectrometry was applied to 13 Buyid silk specimens from the Textile Museum collections. Among these silk specimens, the AAR ratios of only one specimen were consistent with authentic silk fabrics collected from various museums. In addition, the aspartic acid racemization ratio of this specimen was also consistent with its 14 C dating. The other "Buyid silks" showed excessive levels of amino acid racemization not only for aspartic acid, but also for phenylalanine and tyrosine, inconsistent with racemization rates of these amino acids in authentic historical silk fabrics. Treatment of modern silk with a base at different pH and temperature reproduced the AAR pattern of the Buyid silks, implying that chemical treatment with a base at relatively high temperatures was perhaps the method used to artificially age these fabrics. The results imply that the racemization ratios of aspartic acid, phenylalanine, and tyrosine can be used as biomarkers for identification of naturally versus artificially aged silk.

  11. Alkane Biosynthesis Genes in Cyanobacteria and Their Transcriptional Organization

    PubMed Central

    Klähn, Stephan; Baumgartner, Desirée; Pfreundt, Ulrike; Voigt, Karsten; Schön, Verena; Steglich, Claudia; Hess, Wolfgang R.

    2014-01-01

    In cyanobacteria, alkanes are synthesized from a fatty acyl-ACP by two enzymes, acyl–acyl carrier protein reductase and aldehyde deformylating oxygenase. Despite the great interest in the exploitation for biofuel production, nothing is known about the transcriptional organization of their genes or the physiological function of alkane synthesis. The comparison of 115 microarray datasets indicates the relatively constitutive expression of aar and ado genes. The analysis of 181 available genomes showed that in 90% of the genomes both genes are present, likely indicating their physiological relevance. In 61% of them they cluster together with genes encoding acetyl-CoA carboxyl transferase and a short-chain dehydrogenase, strengthening the link to fatty acid metabolism and in 76% of the genomes they are located in tandem, suggesting constraints on the gene arrangement. However, contrary to the expectations for an operon, we found in Synechocystis sp. PCC 6803 specific promoters for the two genes, sll0208 (ado) and sll0209 (aar), which give rise to monocistronic transcripts. Moreover, the upstream located ado gene is driven by a proximal as well as a second, distal, promoter, from which a third transcript, the ~160 nt sRNA SyR9 is transcribed. Thus, the transcriptional organization of the alkane biosynthesis genes in Synechocystis sp. PCC 6803 is of substantial complexity. We verified all three promoters to function independently from each other and show a similar promoter arrangement also in the more distant Nodularia spumigena, Trichodesmium erythraeum, Anabaena sp. PCC 7120, Prochlorococcus MIT9313, and MED4. The presence of separate regulatory elements and the dominance of monocistronic mRNAs suggest the possible autonomous regulation of ado and aar. The complex transcriptional organization of the alkane synthesis gene cluster has possible metabolic implications and should be considered when manipulating the expression of these genes in cyanobacteria. PMID

  12. Management of benign prostatic hyperplasia with silodosin

    PubMed Central

    Yamanishi, Tomonori; Mizuno, Tomoya; Kamai, Takao; Yoshida, Ken-Ichiro; Sakakibara, Ryuji; Uchiyama, Tomoyuki

    2009-01-01

    It has been reported that blockade of α1A-adrenoceptor (AR) relieves bladder outlet obstruction, while blockade of α1D-AR is believed to alleviate storage symptoms due to detrusor overactivity. Silodosin, (−)-1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2trifluoroethoxy) phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7- carboxamide, is a new α1A-AR selective antagonist. Silodosin is highly selective for the α1A-AR subtype, showing an affinity for the α1A-AR that is 583- and 55.5-fold higher than its affinity for the α1B-and α1D-ARs, respectively. In randomized, double-blind, placebo-controlled phase III studies performed in Japan and the United States, silodosin has been shown to be effective for both storage and voiding symptoms associated with benign prostatic hyperplasia. Early effects of silodosin (after 2–6 hours or day 1) on lower urinary tract symptoms have also been reported. In urodynamic studies, detrusor overactivity disappeared in 40% and improved in 35% of patients after administration. In pressure flow studies, the grade of obstruction on the International Continence Society nomogram showed improvement in 56% of patients. The rate of adverse events in the silodosin, tamsulosin and placebo groups was 88.6%, 82.3%, and 71.6%, respectively. The most common adverse event was (mostly mild) abnormal ejaculation (28.1%). However, few patients (2.8%) discontinued silodosin because of abnormal ejaculation. Orthostatic hypotension showed a similar incidence in the silodosin (2.6%) and placebo (1.5%) groups. In conclusion, silodosin improves detrusor overactivity and obstruction and thus may be effective for both storage and voiding symptoms in patients with benign prostatic hyperplasia. PMID:24198606

  13. Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion model

    PubMed Central

    2010-01-01

    Background Polymorphonuclear neutrophils, stimulated by the activated complement factor C5a, have been implicated in cardiac ischemia/reperfusion injury. ADC-1004 is a competitive C5a receptor antagonist that has been shown to inhibit complement related neutrophil activation. ADC-1004 shields the neutrophils from C5a activation before they enter the reperfused area, which could be a mechanistic advantage compared to previous C5a directed reperfusion therapies. We investigated if treatment with ADC-1004, according to a clinically applicable protocol, would reduce infarct size and microvascular obstruction in a large animal myocardial infarct model. Methods In anesthetized pigs (42-53 kg), a percutaneous coronary intervention balloon was inflated in the left anterior descending artery for 40 minutes, followed by 4 hours of reperfusion. Twenty minutes after balloon inflation the pigs were randomized to an intravenous bolus administration of ADC-1004 (175 mg, n = 8) or saline (9 mg/ml, n = 8). Area at risk (AAR) was evaluated by ex vivo SPECT. Infarct size and microvascular obstruction were evaluated by ex vivo MRI. The observers were blinded to the treatment at randomization and analysis. Results ADC-1004 treatment reduced infarct size by 21% (ADC-1004: 58.3 ± 3.4 vs control: 74.1 ± 2.9%AAR, p = 0.007). Microvascular obstruction was similar between the groups (ADC-1004: 2.2 ± 1.2 vs control: 5.3 ± 2.5%AAR, p = 0.23). The mean plasma concentration of ADC-1004 was 83 ± 8 nM at sacrifice. There were no significant differences between the groups with respect to heart rate, mean arterial pressure, cardiac output and blood-gas data. Conclusions ADC-1004 treatment reduces myocardial ischemia-reperfusion injury and represents a novel treatment strategy of myocardial infarct with potential clinical applicability. PMID:20875134

  14. [Comparison of various noninvasive serum markers of liver fibrosis in chronic viral liver disease].

    PubMed

    Kim, Sun Min; Sohn, Joo Hyun; Kim, Tae Yeob; Roh, Young Wook; Eun, Chang Soo; Jeon, Yong Cheol; Han, Dong Soo; Oh, Young Ha

    2009-12-01

    The aim of this study was to determine the clinical performances of noninvasive serum markers for the prediction of liver fibrosis in chronic viral liver diseases. We analyzed a total of 225 patients with chronic viral liver diseases (180 with hepatitis B virus, 43 with hepatitis C virus, and 2 with hepatitis B+C virus) who underwent a liver biopsy procedure at the Hanyang University Guri Hospital between March 2002 and February 2007. Serum was also obtained at the time of liver biopsy. Liver fibrosis was staged according to the scoring system proposed by the Korean Study Group for the Pathology of Digestive Diseases. Various noninvasive serum markers were evaluated, including the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AAR), age-platelet (AP) index, AST/platelet ratio index (APRI), cirrhosis discriminant score (CDS), platelet count, hyaluronic acid (HA), and type IV collagen. There were 17, 40, 61, 74, and 33 patients at stages F0, F1, F2, F3, and F4, respectively. The overall diagnostic accuracies of each marker, as determined by the area under receiver operating characteristics curves, were APRI=0.822, CDS=0.776, platelet count=0.773, AP index=0.756, HA=0.749, type IV collagen=0.718, and AAR=0.642 for predicting significant fibrosis (> or =F2); and CDS=0.835, platelet count=0.795, AP index=0.794, HA=0.766, AAR=0.711, type IV collagen=0.697, and APRI=0.691 for predicting extensive fibrosis (> or =F3). All noninvasive serum markers evaluated in this study were useful for predicting significant or extensive liver fibrosis in chronic viral liver diseases. In particular, APRI was most useful for the prediction of significant fibrosis, and CDS was most useful for the prediction of extensive fibrosis.

  15. Cancer in American Indian and Alaska Native young adults (ages 20-44 years): US, 1999-2004.

    PubMed

    Weir, Hannah K; Jim, Melissa A; Marrett, Loraine D; Fairley, Temeika

    2008-09-01

    An examination of cancer incidence patterns in American Indians and Alaska Native (AI/AN) young adults may provide insight into their present and future cancer burden. To reduce racial misclassification, incidence data were linked with the Indian Health Service (IHS) patient services database. Age-adjusted cancer incidence rates per 100,000 (AAR) and corresponding rate ratios (RR) for young adults (ages 20-44 years) were compared across IHS regions and for selected cancers within Contract Health Service Delivery Area counties by race (AI/AN vs non-Hispanic whites [NHW]) and sex. The all-sites cancer incidence rate was lower for AI/ANs (AAR of 83.8) than for NHWs (AAR of 111.2) (RR of 0.75) but varied by IHS regions. Among the leading cancers in AI/AN females the risk was elevated for stomach (RR of 3.22), colorectal (RR of 1.30), uterine (RR of 1.61), and kidney (RR of 1.39) cancers and was lower for breast (RR of 0.70) and thyroid (RR of 0.71) cancers. Among AI/AN young adult males the risk was elevated for stomach (RR of 2.62), liver (RR of 1.89), and kidney (RR of 1.59) cancers and lower for testicular germ cell cancer (RR of 0.64) and lymphoma (RR of 0.60). The risk for these and other cancers varied across IHS regions. Many of the cancer patterns that characterize the AI/AN population overall are apparent among young adults. Compared with NHW young adults, the overall cancer burden among AI/AN young adults was lower but varied for selected cancers and across IHS regions. Cancer control and research strategies are needed to address the unique genetic, social, cultural, and lifestyle aspects of AI/AN young adults.

  16. Suboptimal performance of simple noninvasive tests for advanced fibrosis in Chinese patients with nonalcoholic fatty liver disease.

    PubMed

    Xun, Yun Hao; Fan, Jian Gao; Zang, Guo Qing; Liu, Hong; Jiang, Yan Ming; Xiang, Jing; Huang, Qian; Shi, Jun Ping

    2012-11-01

    To evaluate the diagnostic accuracy of some noninvasive fibrosis models in Chinese patients with nonalcoholic fatty liver disease (NAFLD). Consecutive biopsy-proven NAFLD patients were recruited from a single center from January 2005 to December 2010. Advanced fibrosis (stage 3 and 4) was defined using Kleiner criteria. The area under the receiver operating characteristic curve (AUROC) was used to compare the diagnostic accuracy of the NAFLD fibrosis score (NFS), FIB-4 index, aspartate transaminase (AST)/platelet ratio index (APRI), AST/alanine transaminase (ALT) ratio (AAR) and body mass index (BMI)-AAR-Diabetes (BARD) score. Of the patients with NAFLD, 79.6% were males with a mean age of 37.1 years, mean BMI of 26.1 kg/m(2) and 41.4% of them had nonalcoholic steatohepatitis, and 24 (15.8%) had advanced fibrosis. The AUROC of the FIB-4 index, APRI, AAR, NFS and BARD score for advanced fibrosis were 0.756, 0.742, 0.670, 0.653 and 0.642 (P < 0.05 for all), respectively. A concordant negative predictive value of approximately 90% was indicated whereas the positive predictive values were modest for all tests, and only the FIB-4 index yielded a higher positive likelihood ratio of 7.65. Using these cut-off values of tests for excluding advanced fibrosis could reduce the use of liver biopsy in 56.6-74.3% of the patients, with a minor false negative rate of 5.3-9.9%. Although slightly less accurate than liver biopsy, simple noninvasive tests can reliably exclude advanced fibrosis in Chinese NAFLD patients in our center. FIB-4 index performs better than the other tests under examination. © 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

  17. Genetic variations in the α(2A)-adrenoreceptor are associated with blood pressure response to the agonist dexmedetomidine.

    PubMed

    Kurnik, Daniel; Muszkat, Mordechai; Li, Chun; Sofowora, Gbenga G; Friedman, Eitan A; Scheinin, Mika; Wood, Alastair J J; Stein, C Michael

    2011-04-01

    α(2A)-Adrenoceptors (α(2A)-ARs) have important roles in sympathetic cardiovascular regulation. Variants of ADRA2A affect gene transcription and expression and are associated with insulin release and risk for type 2 diabetes. We examined whether ADRA2A variants are also associated with cardiovascular responses to the selective α(2)-AR-agonist dexmedetomidine. Seventy-three healthy subjects participated in a placebo-controlled, single-blind study. After 3 infusions of placebo, subjects received 3 incremental infusions of dexmedetomidine (cumulative dose, 0.4 μg/kg). Primary outcomes were changes in systolic blood pressure (SBP) and plasma norepinephrine concentrations, measured as difference of the area-under-the-curve during placebo and dexmedetomidine infusions (ΔAUC). We used multiple linear regression analysis to examine the associations between 9 ADRA2A tagging variants and 5 inferred haplotypes and ΔAUC after adjustment for covariates. Homozygous carriers of rs553668 and the corresponding haplotype 4, previously associated with increased α(2A)-AR expression, had a 2.2-fold greater decrease in AUC(SBP) after dexmedetomidine (adjusted P=0.006); similarly, the maximum decrease in SBP was 24.7±8.1 mm Hg compared with 13.6±5.9 mm Hg in carriers of the wild-type allele (P=0.007). Carriers of haplotype 3, previously associated with reduced α(2A)-AR expression, had a 44% smaller decrease in AUC(SBP) (P=0.013). Haplotype information significantly improved the model predicting the decrease in SBP (P<0.001). There were similar but nonsignificant trends for diastolic blood pressure and heart rate. Genotypes were not significantly associated with norepinephrine responses. Common ADRA2A variants are associated with the hypotensive response to dexmedetomidine. Effects of specific variants/haplotypes in vivo are compatible with their known effects on gene expression in vitro.

  18. Reversible Unfolding of Rhomboid Intramembrane Proteases.

    PubMed

    Panigrahi, Rashmi; Arutyunova, Elena; Panwar, Pankaj; Gimpl, Katharina; Keller, Sandro; Lemieux, M Joanne

    2016-03-29

    Denaturant-induced unfolding of helical membrane proteins provides insights into their mechanism of folding and domain organization, which take place in the chemically heterogeneous, anisotropic environment of a lipid membrane. Rhomboid proteases are intramembrane proteases that play key roles in various diseases. Crystal structures have revealed a compact helical bundle with a buried active site, which requires conformational changes for the cleavage of transmembrane substrates. A dimeric form of the rhomboid protease has been shown to be important for activity. In this study, we examine the mechanism of refolding for two distinct rhomboids to gain insight into their secondary structure-activity relationships. Although helicity is largely abolished in the unfolded states of both proteins, unfolding is completely reversible for HiGlpG but only partially reversible for PsAarA. Refolding of both proteins results in reassociation of the dimer, with a 90% regain of catalytic activity for HiGlpG but only a 70% regain for PsAarA. For both proteins, a broad, gradual transition from the native, folded state to the denatured, partly unfolded state was revealed with the aid of circular dichroism spectroscopy as a function of denaturant concentration, thus arguing against a classical two-state model as found for many globular soluble proteins. Thermal denaturation has irreversible destabilizing effects on both proteins, yet reveals important functional details regarding substrate accessibility to the buried active site. This concerted biophysical and functional analysis demonstrates that HiGlpG, with a simple six-transmembrane-segment organization, is more robust than PsAarA, which has seven predicted transmembrane segments, thus rendering HiGlpG amenable to in vitro studies of membrane-protein folding. Copyright © 2016 Biophysical Society. Published by Elsevier Inc. All rights reserved.

  19. Insulin restores L-arginine transport requiring adenosine receptors activation in umbilical vein endothelium from late-onset preeclampsia.

    PubMed

    Salsoso, R; Guzmán-Gutiérrez, E; Sáez, T; Bugueño, K; Ramírez, M A; Farías, M; Pardo, F; Leiva, A; Sanhueza, C; Mate, A; Vázquez, C; Sobrevia, L

    2015-03-01

    Preeclampsia is associated with impaired placental vasodilation and reduced endothelial nitric oxide synthase (eNOS) activity in the foetoplacental circulation. Adenosine and insulin stimulate vasodilation in endothelial cells, and this activity is mediated by adenosine receptor activation in uncomplicated pregnancies; however, this activity has yet to be examined in preeclampsia. Early onset preeclampsia is associated with severe placental vasculature alterations that lead to altered foetus growth and development, but whether late-onset preeclampsia (LOPE) alters foetoplacental vascular function is unknown. Vascular reactivity to insulin (0.1-1000 nmol/L, 5 min) and adenosine (1 mmol/L, 5 min) was measured in KCl-preconstricted human umbilical vein rings from normal and LOPE pregnancies using a wire myograph. The protein levels of human cationic amino acid transporter 1 (hCAT-1), adenosine receptor subtypes, total and Ser¹¹⁷⁷- or Thr⁴⁹⁵-phosphorylated eNOS were detected via Western blot, and L-arginine transport (0-1000 μmol/L L-arginine, 3 μCi/mL L-[³H]arginine, 20 s, 37 °C) was measured in the presence or absence of insulin and adenosine receptor agonists or antagonists in human umbilical vein endothelial cells (HUVECs) from normal and LOPE pregnancies. LOPE increased the maximal L-arginine transport capacity and hCAT-1 and eNOS expression and activity compared with normal conditions. The A(2A) adenosine receptor (A(2A)AR) antagonist ZM-241385 blocked these effects of LOPE. Insulin-mediated umbilical vein ring relaxation was lower in LOPE pregnancies than in normal pregnancies and was restored using the A(2A)AR antagonist. The reduced foetoplacental vascular response to insulin may result from A(2A)AR activation in LOPE pregnancies. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion model.

    PubMed

    van der Pals, Jesper; Koul, Sasha; Andersson, Patrik; Götberg, Matthias; Ubachs, Joey F A; Kanski, Mikael; Arheden, Håkan; Olivecrona, Göran K; Larsson, Bengt; Erlinge, David

    2010-09-27

    Polymorphonuclear neutrophils, stimulated by the activated complement factor C5a, have been implicated in cardiac ischemia/reperfusion injury. ADC-1004 is a competitive C5a receptor antagonist that has been shown to inhibit complement related neutrophil activation. ADC-1004 shields the neutrophils from C5a activation before they enter the reperfused area, which could be a mechanistic advantage compared to previous C5a directed reperfusion therapies. We investigated if treatment with ADC-1004, according to a clinically applicable protocol, would reduce infarct size and microvascular obstruction in a large animal myocardial infarct model. In anesthetized pigs (42-53 kg), a percutaneous coronary intervention balloon was inflated in the left anterior descending artery for 40 minutes, followed by 4 hours of reperfusion. Twenty minutes after balloon inflation the pigs were randomized to an intravenous bolus administration of ADC-1004 (175 mg, n = 8) or saline (9 mg/ml, n = 8). Area at risk (AAR) was evaluated by ex vivo SPECT. Infarct size and microvascular obstruction were evaluated by ex vivo MRI. The observers were blinded to the treatment at randomization and analysis. ADC-1004 treatment reduced infarct size by 21% (ADC-1004: 58.3 ± 3.4 vs control: 74.1 ± 2.9%AAR, p = 0.007). Microvascular obstruction was similar between the groups (ADC-1004: 2.2 ± 1.2 vs control: 5.3 ± 2.5%AAR, p = 0.23). The mean plasma concentration of ADC-1004 was 83 ± 8 nM at sacrifice. There were no significant differences between the groups with respect to heart rate, mean arterial pressure, cardiac output and blood-gas data. ADC-1004 treatment reduces myocardial ischemia-reperfusion injury and represents a novel treatment strategy of myocardial infarct with potential clinical applicability.