, MA 02115, USA We have generated transgenic mice that harbor a 140 kb genomic fragment of the human the transgene rescues the otherwise lethal phenotype observed in the homozy- gous Brca17/7 mice. We isolated transgenic mice, the Brca1DexllSA mutation was back- crossed into FVB/N mice for 12 ...

Epoxyeicosatrienoic Acid Agonist Rescues the Metabolic Syndrome Phenotype of HO-2-Null Mice Komal system equipped with a Turbo V ion source operated in negative EET-HO-1 in Metabolic Syndrome 907 resistance are key indicators of the metabolic syndrome in these mice. Effect of HO-2 Deletion on Superoxide

... Thus we develop another model to rescue the lack of androgen responsivity of ... were unsuccessful in accomplishing this in intact mice, since the ...

The antipseudomonal effects conferred by combinations of substituted dithiocarbamates, gentamicin or aztreonam (Azactam) were measured and compared to those produced by single agents alone in female BALB/C mice bearing overwhelming Pseudomonas aeruginosa infections. Dimethyldithiocarbamate (DMDTC), diethyldithiocarbamate (DEDTC), and sodium N-methyl-D-glucamine dithiocarbamate ...

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe hereditary bullous disease caused by mutations in COL7A1, which encodes type VII collagen (COL7). Col7a1 knockout mice (COL7^m?/?) exhibit a severe RDEB phenotype and die within a few days after birth. Toward developing novel approaches for treating patients with RDEB, we attempted to ...

Mutations leading to nephrin loss result in massive proteinuria both in humans and mice. Early perinatal lethality of conventional nephrin knockout mice makes it impossible to determine the role of nephrin protein in the adult kidney and in extra-renal tissues. Herein, we studied whether podocyte-specific, doxycycline-inducible, rat nephrin expression can ...