The MELCOR computer code has been used to model four of the large-scale aerosol behavior experiments conducted in the Containment System Test Facility (CSTF) vessel. Tests AB5, AB6 and AB7 of the ABCOVE program simulate the dry aerosol conditions during a...

The MELCOR computer code has been used to model four of the large-scale aerosol behavior experiments conducted in the Containment System Test Facility (CSTF) vessel. Tests AB5, AB6 and AB7 of the ABCOVE program simulate the dry aerosol conditions during a hypothetical severe accident in an LMFBR. Test LA2 of the ...

The MELCOR code was used to simulate the ABCOVE Aerosol experiments AB5, AB6, and AB7. In these tests, a dry sodium aerosol was introduced into an 850 m sup 3 vessel and the aerosol behavior was monitored. Single and double component aerosols were used. O...

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NKL were immunoprecipitated with a control immunoglobulin (cIg) or affinity-purified anti-DAP10 or a polyclonal NK cell line were labeled with 125 I, lysed in 1% digitonin, and immunoprecipitated with cIg expressing the indicated receptors were stained with cIg, Flag mAb M2, or NKG2D mAb 5C6 [or 1D11 mAb (7

The lack of selective inhibitors toward the long, short, or supershort phosphodiesterases (PDE4s) prevented researchers from carefully defining the connection between different enzyme isoforms, their brain localization, and their role in neurodegenerative diseases such as Alzheimer's disease (AD). In the search for new therapeutic agents for treating memory and learning disorders, we synthesized ...

Nox4, a member of Nox family of NADPH oxidase expressed in nonphagocytic cells, is a major source of reactive oxygen species in many cell types. But understanding of the role of Nox4 in the production of ROS and of regulation mechanism of oxidase activity is largely unknown. This study reports for the first time the generation and characterization of 5 mAbs against a recombinant Nox4 protein (AA: ...

The hydrogen bonding interactions between noradrenaline (NA) and DMSO were studied with density functional theory (DFT) regarding their geometries, energies, vibrational frequencies, and topological features of the electron density. The quantum theory of atoms in molecules (QTAIM) and the natural bond orbital (NBO) analyses were employed to elucidate the hydrogen bonding interaction ...

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... Calmette-Guerin (BCG) and levamisole to interferon, interleukins and monoclonal antibodies (mAb) (6-8). The purpose of the present study is to ...

... Two mAbs, 5A7 and 11F11, were produced by hybridomas derived from mice immunized by a recombinant HER-2/neu ECD tagged by a ...

The objective of the program is to obtain sufficient analytical and experimental data to provide a basis for judging the adequacy of existing aerosol behavior computer codes that describe inherent attenuation processes. The test facilities and test results are presented for Test AB5.

The effect of chlorpromazine, one of several calmodulin antagonists that inhibit cytoskeletal movement, on the local kinetics of injected proteinuria-inducing MoAb 5-1-6 was examined to test the hypothesis that proteinuria is inhibited if the antigen recognized by MoAb 5-1-6 or injected MoAb remains on the surface ...

A series of monoclinic compounds DyCux (/x=4.5,4 and 3.5) is described. It is constructed from structural blocks AB5 (cubic AuBe5 structure type) and AB2 (cubic MgCu2 structure type) by stacking nAB5+AB2 and giving the compositions A2B7,AB4,A4B17,A5B22,A6B27,...,AB5. The ...

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of those that we have tested, we found Hamilton cycles. In the table below the cycles are presented- tions mentioned above are used (labels of graphs are from 1]): 1. 108] (abc)3 = (ab)2c(ba)2c = e, ((ab)2ac)2(ba)2bc(ba)5bc(ac)2(ba)5bc(ba)2bc(ab)2ac(ab)4ac(ab)5ac(ba)2bc (ba)2bc(ab)5ac(ab)2 2. 120B] ...

Foot and mouth disease virus (FMDV) viral protein 1 is the only one of the four viral proteins (VP) that induces neutralizing antibodies as an isolated protein. A 32 amino acid (AA) residue (32dimer) of FMDV subtype A12 Lp ab VP1 (AA 137-168) was immunogenic against the A12 subtype. Three antibody populations each recognizing different epitopes on 32dimer were isolated by affinity chromatography ...

... wo mAbs, 5AT and l lFl , were produced by hybridomas derived from mice immunized by a ecombinant HER-2/neu ECD tagged by a polyhistidine ...

Advanced Hepatocellular Carcinoma (HCC) Stage C According to BCLC Classification Restricted to Child-Pugh Class A/B (5-7 Points).

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Angiotensin I-converting enzyme (ACE, peptidyl dipeptidase, EC 3.4.15.2) is a key enzyme in cardiovascular pathophysiology. A wide spectrum of monoclonal antibodies to different epitopes on the N and C domains of human ACE has been used to study different aspects of ACE biology. In this study we characterized the monoclonal antibody (mAb) 5F1, developed ...

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is a special case and cannot be guaranteed by the x-contract itself but by the human being or system (software be performed infinitely often. For example, an x-contract between a bank and a customer should guarantee of Electronic Contracts Ellis Solaiman, Carlos Molina-Jimenez, and Santosh Shrivastava School of Computing

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The crystal structure of triaminoguanidinium chloride (TAGC1) was refined using three dimensional x-ray diffraction data. The hexagonal structure (P6(3)/m) has unit-cell dimensions: a=b=7.480(1) A and, c=6.218(1) A. The structure consists of layers of ion...

columns are present in very young visually naive monkeys. Recordings were made from area 17 in two macaque monkeys three and four weeks of age, whose eyes had been closed near the time of birth. The first monkey determined and not the result of early visual experi- ence. In these two monkeys and a third one, sutured

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The current study evaluates the measurement precision of the Abridged Big Five Circumplex (AB5C) of personality traits by identifying those items that demonstrate differential item functioning by gender and ethnicity. Differential item functioning is found in 33 of 45 (73%) of the AB5C scales, across gender and ethnic groups (Caucasian vs. African ...

.J. Brockwell and R.A. Davis. Related courses: SS361a/b, SS529a/b 6. Multivariate Statistical Analysis components; factor analysis; multivariate analysis of variance. References: Applied Multivariate Statistical Analysis, R. Johnson and D. Wishern (Prentice Hall); An Introduction to Multivariate Statistical Analysis

We report the formation and systematic struc-tural characterization of a new AB(6) polymorph with the body-centered cubic (bcc) symmetry in binary nanocrystal superlattices (BNSLs). The bcc-AB(6) phase, lacking any atomic analogue, is isomorphic to certain alkali-metal intercalation compounds of fullerene C(60) (e.g., K(6)C(60)). On the basis of the ...

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Identical ?-lactamase-encoding (TEM-1) plasmids were found in two different clinical Neisseria meningitidis strains. They were completely sequenced (5,597 bp) and designated pAB6. The plasmid is almost identical to Neisseria gonorrhoeae plasmid pJD5 (5,599 kb) and may have been picked up from a gonococcus in vivo.

than in PBS buffer, indicating that the wheat extract interfered with binding of the mimotope peptide of Mimotope Peptides Which Bind to the Mycotoxin Deoxynivalenol-Specific Monoclonal Antibody QIAOPING YUAN,1 phage displayed peptides bound to mAb 6F5 specifically at the DON binding site. The amino acid sequence

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Liu, XL Wang J Volf Alloy Sheathed Bi-2223 HTS Tapes for Current Leads HK Liu, M Apperley #12;9 Energy for Electric Vehicles HK Liu, D Bradhurst Masters A Howes Stoichiometric and Non-Stoichiometric AB5 Type Alloys Supervisors R Baker Zeeman and Piezospectroscopy of Antimony and Aluminum in Germanium P Fisher, R Vickers D

A process for treating an AB5 Ni-MH battery to recover purified positive and negative electrode components of the battery is disclosed. An AB5 Ni-MH battery is placed in a mineral acid leach solution to cause the positive and negative electrode components of the battery to separate.

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HAb18G/CD147, a glycoprotein of the immunoglobulin super-family (IgSF), is a T cell activation-associated molecule. In this report, we demonstrated that HAb18G/CD147 expression on both activated CD4(+) and CD8(+) T cells was up-regulated. In vitro cross-linking of T cells with an anti-HAb18G/CD147 monoclonal antibody (mAb) 5A12 inhibited T cells ...

This document studies the effects of a mild water stress and carbonic anhydrase activity by ethoxyzolamide (EZA) on the diffusion of CO(sub 2) in leaves, by (sup 18)O labelling of O(sub 2) and of CO(sub 2) associated to mass spectrometry. (A.B.). 5 refs.,...

Cytokines (100 ug) are available only to investigators with peer-reviewed support. The mAbs (5 and 20 mg) and cytokine standards (approx.1 ug) are available to peer-reviewed investigators, for-profit institutions, and commercial establishments.

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A program for aerosol behavior validation and evaluation (ABCOVE) has been developed in accordance with the LMFBR Safety Program Plan. The ABCOVE program is a cooperative effort between the USDOE, the USNRC, and their contractor organizations currently involved in aerosol code development, testing or application. The third large-scale test in the ABCOVE program, ...

Two temperature-sensitive (ts) strains, 1B and 1H, were obtained after nitrosoguanidine treatment of the wild-type virulent abortive ovine strain Chlamydia psittaci AB7. Optimum growth temperature on McCoy cells was 38 degrees C for the three strains, but at the restrictive temperature, 39.5 degrees C, ts strains differed from the parental strain in their ...

Outbreaks of koi herpesvirus (KHV) infection in carp are still a serious problem worldwide. KHV is closely related to other two cyprinid herpesviruses, pox herpesvirus (CHV) and haematopoietic necrosis herpesvirus (CyHV-2) in goldfish. In this study, two major KHV antigenic proteins (ORF62 and ORF68) were identified by immunoscreening using a KHV-specific polyclonal antibody, and then monoclonal ...

IntroductionThe complement system is an essential part of the immune system of vertebrates. The central event of the complement activation cascade is the sequential proteolytic activation of C3, which is associated with profound alterations in the molecule's structure and conformation and is responsible for triggering most of the biological effects of complement.Material and methodsHere, we have ...

The microtubule-associated protein tau that is incorporated into paired helical filaments (PHFs) undergoes some form of aberrant posttranslational processing in Alzheimer disease. Difficulties in deciding which changes are critical for PHF formation stem in part from the lack of immunochemical markers specific for PHF tau. The only monoclonal antibody (mAb) that is known to react with PHF tau but ...

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). Preliminary tests also indicate that some loci amplify in other coccinellid species. Three loci (Ab1, Ab6 and Ab8) were tested for ampli- fication in Harmonia axyridis and Exochomus 4-pustulatus. Successful), allowing amplification to be tested at 12 annealing temperatures (range 50�65 �C, interval 1.36 �C

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Monoclonal antibodies (mAbs) have taken on an increasing importance for the treatment of various diseases including cancers, immunological disorders, and other pathologies. These large biomolecules display specific structural features, which affect their efficiency and need, therefore, to be extensively characterized using sensitive and orthogonal analytical techniques. Among them, mass ...

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This article explores high-maintenance students in the university setting: those students who complain and whine, beyond reasonable limits, thereby exhausting their instructor's energy. By drawing heavily on the personality literature, I advance a conceptual foundation, research propositions, and suggestions for future research regarding high-maintenance students. Specifically, the abridged big ...

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This lesson on locating a business, the seventh in a series of 18 units, is part of the first level of a comprehensive entrepreneurship curriculum entitled: A Program for Acquiring Competence in Entrepreneurship (PACE). (Designed for use with secondary students, the first level of PACE introduces students to the concepts involved in entrepreneurship and helps them become aware of entrepreneurship ...

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Genetic factors influence adverse pregnancy outcome in both humans and animal models. Animal research reveals that both the maternal and fetal genetic profiles are important for determining the risk of physical birth defects and prenatal mortality. Using a reciprocal-cross breeding design, we investigated whether the mother's genes may be more important than fetal genes in determining risk for ...

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Two unlinked genes of the mouse, Skn-1 and Skn-2, each with alterative alleles, specify alternative cell-surface Skn alloantigens expressed only by epidermal and neural cells. C57BL/6 (B6) and A/J (A) strain mice differ at both Skn loci. Thus lethally irradiated B6 mice restored with (B6 x A)F1 hybrid hematopoietic cells [(B6 x A)/B6 chimeras] reject A strain (Skn-incompatible) skin grafts. Our ...

A systematic search for disklike edge-on galaxies with a diameter larger than a=40 arcsec and major-to-minor axis ratio a/b>7 has been carried out by means of Palomar Observatory Sky Survey and ESO/SERC survey. As a result, we present new catalog of a flat galaxies (FGC) containing 4455 objects and covering about 56% of the whole sky for the first time. The catalog is assigned to study ...

In order to develop an anti-FMDV A Type monoclonal antibody (mAb), BABL/c mice were immunized with FMDV A type. Monoclonal antibodies (mAbs) 7B11 and 8H4 against Foot-and-mouth disease virus (FMDV) serotype A were produced by fusing SP2/0 myeloma cells with splenocyte from the mouse immunized with A/AV88. The microneutralization titer of the ...

28004207 ARCELIN Jeremy27000875 6,5 3,25 3,5 10,88 11 ARMOUGOM Gianny29005367 4 1,75 -abs- 5,75 6 ASSI Mahmoud28004279 0 7 5 13,25 13 ATMA Simon26001695 AUBRY Magali28002486 3 2,5 3,5 7,38 7 AZZID Imad28000262 4 6,5 6 14 14 BASILE Antoine28003928 6,5 5,5 2,5 12 12 BAUJARD Romain27001415 3,5 -abs- 4 8,5 9

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The present invention provides a non-stoichiometric alloy comprising a composition having the formula AB.sub.5+X an atomic ratio wherein A is selected from the group consisting of the rare earth metals, yttrium, mischmetal, or a combination thereof; B is nickel and tin, or nickel and tin and at least a third element selected from the group consisting of the elements in group IVA of the periodic ...

Cobalt-free La(Ni,Sn)_5+x alloys have been identified as low cost, corrosion resistant electrodes for nickel-metal-hydride batteries. The structure of theses alloys are similar to non-stoichiometric La(Ni,Cu)_5+x compounds; i.e., they retain the P6/mmm space group while Ni dumbbells occupy La sites. Electrodes fabricated from some of these novel alloys ...

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Some dielectric oxides have been synthesized and characterized in the BaO-La{sub 2}O{sub 3}-TiO{sub 2}-Nb{sub 2}O{sub 5} system. Through Rietveld refinement of X-ray powder diffraction data, Ba{sub 5}LaTi{sub 2}Nb{sub 3}O{sub 18} and Ba{sub 4}La{sub 2}Ti{sub 3}Nb{sub 2}O{sub 18} are identified as the A{sub n}B{sub n-1}O{sub 3n} (n=6) type cation-deficient perovskites with space group R3-bar m and ...

Some dielectric oxides have been synthesized and characterized in the BaO-La2O3-TiO2-Nb2O5 system. Through Rietveld refinement of X-ray powder diffraction data, Ba5LaTi2Nb3O18 and Ba4La2Ti3Nb2O18 are identified as the AnBn?1O3n (n=6) type cation-deficient perovskites with space group R3m and lattice constants a=b=5.7106(1)�, and c=42.0666(5)� for Ba5LaTi2Nb3O18; a=b=5.6602(1)�, and ...

We examined the effects of CD40 activation with dexamethasone (Dex) or 60Co-gamma-irradiation on the growth of malignant B cells in vitro, using the human multiple myeloma (MM) cell line, XG2, and the B lymphoma Daudi cell line as models. Both lines are resistant to Dex and irradiation; 10(-7)M Dex or 10 Gy of gamma-irradiation induced only minimal growth arrest and apoptosis of the cells. ...

CD40, a member of the tumor necrosis factor receptor superfamily, is widely expressed on various cell types. Some studies show that CD40 expression is related to several carcinomas, where its function remains largely unknown. This study investigated the expression of CD40 on cervical carcinoma and evaluated the effect of agnostic anti-CD40 mAb (5C11) on ...

The Radiological Environmental Monitoring (REM) group at the Fernald Environmental Management Project is involved in an Electronic Data Transfer practice that will result in the improved quality assurance of collected data. This practice focuses on electronic data transfer from the recording instrument to reduce the manpower normally required for manual data entry and improve the quality of the ...

Monoclonal antibodies (mAbs) to prostate-specific antigens, such as PSMA, have great potential as diagnostic and therapeutic tools in the management of advanced prostate cancer. PSMA is a very attractive target for mAb-based imaging. It is expressed by virtually all prostate cancers and its expression is further increased in poorly differentiated, metastatic, and hormone-refractory carcinomas. The ...

New glassy 1,3-dioxo-1H-inden-2(3H)-ylidene fragment und (3-(dicyanomethylene)-5,5-dimethylcyclohex-1-enyl)vinyl fragment containing push-pull type derivatives of azobenzene able to create thin layers have been synthesized. Thin films of synthesized glasses for holographic recording were prepared using spin coating technique from saturated chloroform solution. Holographic grating recording in ...

En base a observaciones espectrosc�picas en el rango �ptico, obtenidas en el CASLEO, se estudian las condiciones f�sicas de tres regiones H II alrededor de estrellas WR: N76 en el entorno de Ab7, en la Nube Menor de Magallanes, N79 alrededor de Br 2, en la Nube Mayor de Magallanes y G2.4+1.4 alrededor de WR 102, en nuestra Galaxia. Estas regiones ...

In this paper, a simple method of pulse narrowing by double Q-switching is presented. In energy transfer distributed feedback dye laser (ETDFDL) when acceptor dye acts as a saturable absorber, pulse narrowing is observed in both donor and acceptor emission regions. In prism-dye cell configuration using second harmonic of Nd-YAG laser as pump source, the ETDFDL output is obtained from dyes ...

Trichinella spiralis paramyosin (Ts-Pmy) is a protective antigen that induces partial immunity against T. spiralis infection in mice. To identify protective epitope of Ts-Pmy, a monoclonal antibody (mAb) 7E2 against the recombinant protein was generated, which partially protected against T. spiralis infection following passive transfer. The mAb was used to ...

This paper describes an antibody (mAb 7D6) that specifically recognizes human follicular dendritic cells (FDCs). By expression cloning, a cDNA clone encoding for the long human CR2/ CD21 isoform (CD21L) that contains an additional exon (10a) was isolated. We demonstrated that FDCs selectively express CD21L, while B cells selectively express the short ...

Novel thiazolidin-4-one-linked pseudodisaccharides 3-6 were synthesized by the one-pot tandem Staudinger/aza-Wittig/cyclization reaction at room temperature. The deacetylation of 3-6 afforded compounds 7-10, respectively. The structures of the new compounds were determined using single crystal X-ray crystallography, (1)H, (13)C, and 2D NMR spectroscopy, and HR mass spectrometry. The preliminary ...

The different fragments of the third complement component, C3, generated upon complement activation/inactivation have the ability to bind to several other complement components and receptors as well as to proteins of foreign origin. These multiple reactivities of C3 fragments are associated with a series of conformational changes occurring in the C3 molecule during its degradation. The ...

The Agrobacterium Ti plasmid (T-DNA) 6b proteins interact with many different host proteins implicated in plant cell proliferation. Here, we show that Arabidopsis plants overexpressing 6b display microRNA (miRNA) deficiency by directly targeting SERRATE and AGO1 via a specific loop fragment (residues 40�55). In addition, we report the crystal structures of Agrobacterium tumefaciens AK6b at 2.1 ...

The linac based on SC cavities has special features. Due to specific requirements the SC cavity is desirable to have a constant geometry of the accelerating cells with limited family number of cavities. All cavities are divided into modules, and each module is housed into one cryostat. First of all, such geometry of cavity leads to a non-synchronism. Secondly, the inter-cryostat drift space ...

This report describes the characterisation of a monoclonal antibody (mAb), AB6, which recognises specifically a cluster of canine leukocyte surface molecules. The immunogen used for obtaining the AB6 mAb was a lysate of canine peripheral blood mononuclear cells (PBMC). This novel mAb belongs to the IgG2a isotype, and reacted in Western blot with four ...

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During preclinical development of neuroprotective antiaddiction therapeutic monoclonal antibodies (mAbs) against phencyclidine (PCP) and (+)-methamphetamine, we discovered novel, gestation stage-specific changes in mAb disposition spanning the entire reproductive cycle of female rats. Each pharmacological change was independent of mAb dose and antigen target but was precisely coincident with ...

When breathalyser tests are used to detect whether a person in charge of a vehicle is incapable of activing due to the influence of alcohol. The difficulties which arise are not limited to the extent to which these modern methods are forensically sound but extend to the question whether it is legally permissible to implement random breathanalysing. It is doubtful whether a duty to take a breath ...

Yttrium tricopper dialuminium, YCu(3)Al(2), is isostructural with hexagonal CaCu(5), in which each Cu atom at the 3g((1/2),0,(1/2)) position in space group P6/mmm (No. 191) is partially replaced by an Al atom. The hydrogen-uptake properties are usually enhanced in other AB(5) structures by aluminium substitution. YCu(5) does not show any hydrogen ...

We present u-, g-, r-, i- and z-band optical images and associated catalogues taken primarily with the Isaac Newton Telescope Wide Field Camera on the European Large Area ISO Survey (ELAIS) N1 and N2, First Look Survey and Lockman Hole fields comprising a total of 1000 h of integration time over 80 deg2 and approximately 4.3 million objects. In this paper we outline the observations and data ...

We present u-, g-, r-, i- and z-band optical images and associated catalogues taken primarily with the Isaac Newton Telescope Wide Field Camera on the European Large Area ISO Survey (ELAIS) N1 and N2, First Look Survey and Lockman Hole fields comprising a total of 1000 h of integration time over 80 deg2 and approximately 4.3 million objects. In this paper we outline the observations and data ...

3-Substituted 2,3-dihydrobenzofuranes (7a-c), 1,2-dihydronaphtho(2,1-b)furanes (10a-c), and N-substituted 2,3-dihydro-1H-indoles (8a-c, 9a,b) are obtained in very good yields by S(RN)1 photostimulated reactions in liquid ammonia from adequate haloaromatic compounds ortho-substituted with a suitable double bond (3a,b; 4a,b; 5a; 6a,b) and Me3Sn-, Ph2P-, and -CH2NO2 anions. The novelty of the work ...

We report the crystallographic parameters of LaMnO3 obtained from X-ray diffraction data and electronic properties predictions using the density functional theory (DFT). LaMnO3 was prepared by the citrate precursor method (CPM). The initial solution was 0.1 M of each cation and the citrate nitrate relation was one. The solution was dried at 373 K; the yielded foam was annealed at 873 K and then ...

Human emotional behavior, personality, and body language are the essential elements in the recognition of a believable synthetic story character. This paper presents an approach using story scripts and action descriptions in a form similar to the content description of storyboards to predict specific personality and emotional states. By adopting the Abridged Big Five Circumplex ...

The NIP is a near infrared imaging photometer that is currently under investigation for the Euclid space mission in context of ESA's 2015 Cosmic Vision program. Together with the visible camera (VIS) it will form the basis of the weak lensing measurements for Euclid. The NIP channel will perform photometric imaging in 3 near infrared bands (Y, J, H) covering a wavelength range from ~ 0.9 to 2 ?m ...

A new lattice gas model has been developed, describing the hydrogen storage in hydride-forming materials. This model is based on the mean-field theory and Bragg-Williams approximation. To describe first-order phase transitions and two-phase coexistence regions, a binary alloy approach has been adopted. A complete set of equations describing pressure-composition isotherms and equilibrium electrode ...

Multi-substituted LaNi5-type alloys (AB5+x) are widely used as negative electrode materials in commercial Ni-MH batteries. Cobalt substitution on Ni sites allows to enhance battery cycle life by reducing alloy pulverization induced by hydrogen cycling. This improvement is attributed to the occurrence of a three-phase process (?, ? and ?) during ...

A composite of Ti-V-based bcc phase alloy surface-modified with AB5 nanoparticles was prepared by ball milling. The composite showed significantly improved electrochemical hydrogen release capacities. For example, the 30 min ball milled Ti-30V-15Mn-15Cr+10 wt %AB5 showed a discharge capacity in the first cycle, at 353 K, of 886 mA h g-1, corresponding to ...

We report the first direct observation of the oxygen-isotope ((16)O/(18)O) effect on the in-plane penetration depth lambda(ab) in a nearly optimally doped YBa(2)Cu(3)O(7-delta) film using the novel low-energy muon-spin rotation technique. Spin-polarized low-energy muons are implanted in the film at a known depth z beneath the surface and process in the local magnetic field B(z). This feature ...

The exploitation of coal in Southeastern Ohio is associated to the production of acid mine drainage and poor water quality in rivers and streams. Water recharge to the underground coal mines occurs preferentially throughout subsidence features in areas where the overburden is thinner than around 60 feet, usually close to river and streams. Gases released from the coal beds such as methane and ...

Unsymmetrical N,N'-bisalkylidene hydrazines 7a,b, 10a-c and 13, which are accessible in good to excellent yields from hydrazones 6, 9, and 12 and commercially available ?,?-unsaturated carbonyl compounds, are converted into 3,4-diazaheptatrienyl anions 14a,b, 16a-c, and 18 by treatment with KO-t-Bu as base. These anionic species form pyridines 15a,b, 5,6-dihydrobenzo[h]quinolones 17a-c, and ...

Forty alkaloids were detected and characterized from skin extracts of high- and low-elevation populations of the poison frog Dendrobates histrionicus from northwestern Colombia. Combined gc/ms with NH3 or ND3 in a chemical ionization mode detected protonated parent ions and determined the number of exchangeable NH and OH hydrogens. Six previously unknown dendrobatid alkaloids were characterized. ...

A program for aerosol behavior code validation and evaluation (ABCOVE) is in progress in the United States. Purpose of the ABCOVE program is to provide a basis for judging the adequacy of existing aerosol behavior computer codes to describe inherent aerosol behavior in containment buildings during postulated breeder reactor accidents. The program involves pretest calculations by code developers ...

Cholera toxin (CT) travels as an intact AB(5) protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin. Translocation of CTA1 from the ER to the cytosol is then facilitated by the quality control mechanism of ER-associated degradation (ERAD). ...

BackgroundBlockade of the CD28 costimulatory molecule by recombinant human (h)CTLA4-Ig or CD40-CD154 interaction with the monoclonal antibody (mAb) 5C8 together with donor-specific-transfusion led to enhanced engraftment in the canine model of DLA-identical marrow transplantation after 1 Gy total body irradiation (TBI). In order to reduce or eliminate TBI ...

In order to define the possible role of the MDM2 gene in the pathogenesis of human leukemia, the expression of MDM2 protein was examined in samples of fixed-permeabilized peripheral blood (PB) or bone marrow (BM) cells of leukemic patients by using flow cytometry. The present study showed, that normal PB and BM cells expressed low levels of MDM2. Overexpression of this protein was more frequently ...

In the presence of bound Mn²⁺, the three- dimensional structure of the ligand-binding A-domain from the integrin CR3 (CD11b/CD18) is shown to exist in the �open� conformation previously described only for a crystalline Mg²⁺ complex. The open conformation is distinguished from the �closed� form by the solvent exposure of F302, a direct ...

CD4(+) CD25(+) regulatory T (Treg) cells expressing Foxp3(+) play a critical role in maintaining immune homeostasis and controlling excessive immune responses. However, controversy about the immunoregulatory role of Treg cells exists in malaria studies. Given the role of maintenance of Foxp3 expression in Treg cells activities, we investigated whether anti-CD25 mAb ...

Medical countermeasures to prevent or treat smallpox are needed due to the potential use of poxviruses as biological weapons. Safety concerns with the currently available smallpox vaccine indicate a need for research on alternative poxvirus vaccine strategies. Molecular vaccines involving the use of proteins and/or genes and recombinant antibodies are among the strategies under current ...

BACKGROUND: There is no consensus about the most effective method for transarterial chemoembolisation of hepatocellular carcinoma. AIM: The aim of this phase II trial was to compare the efficacy and toxicity of lipiodol transarterial chemoembolisation with amiodarone in association with pirarubicin or doxorubicin versus lipiodol transarterial chemoembolisation with anthracycline alone in a control ...

The venom of Loxosceles intermedia (Li) spiders is responsible for cutaneous lesions and other clinical manifestations. We previously reported that the monoclonal antibody LimAb7 can neutralize the dermonecrotic activity of crude Li venom. In this study, we observed that this antibody recognizes several proteins from the venom dermonecrotic fraction (DNF), ...

Nine monoclonal antibodies (mAbs) against avian influenza virus (AI) H5 subtype from mice immunized with inactivated virus H5N1 (A/Turkey/ON/6213/66) were produced. Upon testing, the results indicated that the binding epitopes of eight out of the nine mAbs were conformational, while one mAb (#7) reacted with denatured H5N1 only. Two mAbs #10 and #11 ...

Forskolin (Fo), a cardiovascular active diterpene of plant origin, has been widely used as a research tool in regulation of the catalytic activity of adenylate cyclase (AC). A linear relationship of Fo binding to plasma membrane with activation of AC has been reported. The present abstract describes the production and assay of Fo antibodies (AB). ...

We report on the results of measurements of anisotropic resistivity of RBa2Cu3O6 + x (R = Tm, Lu) high-temperature superconducting single crystals in a wide range of doping levels, indicating a nontrivial effect of magnetic order on the electronic properties of cuprates. In particular, our results visually demonstrate the crossover from the state with moderate anisotropy of resistivity ? c /? ab ...

The role of amyloid-? (A?) in the neurodegeneration of Alzheimer�s disease remains controversial, to a large extent because of the lack of robust neurodegeneration in mouse models of AD. To address this question, we examined the effects of A? antibodies in the recently described monoaminergic (MAergic) axonal degeneration in A?PPswe/PS1dE9 mice. To determine if A? accumulation is directly ...

The 49-residue functional upstream domain (FUD) of Streptococcus pyogenes F1 adhesin interacts with fibronectin (FN) in a heretofore unknown manner that prevents assembly of a FN matrix. Biotinylated FUD (b-FUD) bound to adsorbed FN or its recombinant N-terminal 70-kDa fibrin- and gelatin-binding fragment (70K). Binding was blocked by FN or 70K, but not by fibrin- or gelatin-binding subfragments ...

The development of antibodies (Abs) to major histocompatibility (MHC) class I related chain A (MICA) and human leukocyte antigen (HLA) and their role in the immunopathogenesis of chronic rejection (bronchiolitis obliterans syndrome (BOS)) following human lung transplantation (LTx) was analyzed. Sera from 80 LTx recipients were analyzed for anti-MICA and anti-HLA Abs using Luminex and flow PRA ...

Natural engagement of CTLA-4 on host B7 limits T cell activation. We hypothesized that therapeutic cross-linking of CTLA-4 in vivo may further inhibit T cell function and prevent allograft rejection. However, none of the currently available CTLA-4-binding reagents have ligating properties when injected in vivo. The observation that surface-immobilized anti-CTLA-4 mAb inhibits T cell activation in ...

The crystal structure of a murine mAb, 4C3, that binds to the C-terminal lobe of the cockroach allergen Bla g 2 has been solved at 1.8 � resolution. Binding of 4C3 involves different types of molecular interactions with its epitope compared with those with the mAb 7C11, which binds to the N-terminal lobe of Bla g 2. We found that the 4C3 surface epitope ...

A phosphate-rich clast in a pigeonite-plagioclase mineral assemblage occurs in Apollo 17 impact-melt breccia 76503,7025. The clast, measuring 0.9 x 0.4 mm in thin section, contains 3.3 percent (volume) apatite (Ca5P3O12(F,Cl)), 0.8 percent whitlockite (Ca16(Mg,Fe)2REE2P14O56), and trace monazite ((LREE)PO4). Major minerals include 26 percent pigeonite, En53-57FS34-35W08-13, and 69 percent ...

Electronic structure calculations, steady-state electronic spectroscopy, and femtosecond time-resolved emission spectroscopy are used to examine the photophysics of trans-4-(dimethylamino)-4'-cyanostilbene (DCS) and its solvent dependence. Semiempirical AM1/CI calculations suggest that an anilino TICT state is a potential candidate for the emissive state of DCS in polar solvents. But observation ...

Miller Range (MIL) 05035 is a low-Ti mare basalt that consists predominantly of pyroxene (62.3 vol%) and plagioclase (26.4 vol%). Pyroxenes are strongly shocked and complexly zoned from augite (Wo33) and pigeonite (Wo17) cores with Mg# = 50-54 to hedenbergite rims. Coexisting pyroxene core compositions reflect crystallization temperatures of 1000 to 1100 �C. Plagioclase has been completely ...

Pancreatic cancer (PC) has a poor clinical prognosis with a <10% 5-year survival rate. Because there are no specific biomarkers of PC, it is difficult to detect small PC tumors and most patients are diagnosed at an advanced stage. Specific biomarkers are useful tools for the early detection of cancer. However, PC-related biomarkers, such as CA19-9 lack specificity and sensitivity. In this ...

Neuronal degeneration is one of the hallmarks of Alzheimer's disease (AD). Given the paucity of molecular markers available for the identification of neuronal subtypes, the specificity of neuronal loss within the cerebral cortex has been difficult to evaluate. With a panel of four monoclonal antibodies (mAbs) applied to central nervous system tissues from AD patients, the authors have ...

mAb were selected that inhibited IgE-mediated histamine release from human basophils. The two mAb, HB 9AB6 and HB 10AB2, are of the IgG1 subclass and have a 50% inhibitory concentration of 0.16 to 1.1 micrograms/ml. The mAb required several hours of incubation with the basophils at 37 degrees C to induce maximum inhibition. Neither mAb directly released ...

Three sets of in silico experiments have been conducted to elucidate the binding mechanics of two drugs, (+)-methamphetamine (METH) and amphetamine (AMP) to the single-chain variable fragment (scFv) recently engineered from anti-METH monoclonal antibody mAb6H4 (IgG, ?light chain, K(d)=11nM). The first set of in silico experiments are long time ...

Expression of recombinant vaccine antigens and monoclonal antibodies using plant viral vectors has developed extensively during the past several years. The approach benefits from high yields of recombinant protein obtained within days after transient delivery of viral vectors to leaves of Nicotiana benthamiana, a tobacco relative. Modified viral genomes of both RNA and DNA viruses have been ...

Five hybridoma cell lines secreting anti-PrP antibodies were established from the fusion between mouse myeloma Sp2/0 and spleen cells from mice immunized with recombinant Chinese Luxi yellow cattle (Bos taurus, Luxi) PrP (24-234) or recombinant Chinese small-tailed Han sheep PrP (94-227). According to their Western blot reactivity, five monoclonal antibodies (mAbs) could be divided into two ...

In previous crystal structure studies on each of these compounds the only analogy drawn between the two was by Theobald et al., who recognized the similar unit cell dimensions but who noted that the reported space group, B2ab(6), was different from all the possible space groups previously considered for [gamma]-Bi[sub 2]MoO[sub 6]. The crystal structure of ...

Adsorption governs the fate of Cry proteins from genetically modified Bt crops in soils. The effect of ionic strength (I) on the adsorption of Cry1Ab (isoelectric point IEP(Cry1Ab) ? 6) to negatively charged quartz (SiO(2)) and positively charged poly-L-lysine (PLL) was investigated at pH 5 to 8, using quartz crystal microbalance with dissipation ...

We have previously described a monoclonal antibody (mAb), 1C1E7, against von Willebrand factor (VWF), that increases ristocetin-induced platelet aggregation (RIPA) and induces a preferential binding of the high-molecular-weight multimers of VWF to platelet GPIb. Further investigations using a rotational viscometer at a shear rate of 4000 s(-1) could now demonstrate that shear-induced platelet ...

Phenylalkylamines that possess conformationally rigidified furanyl moieties in place of alkoxy arene ring substituents have been shown previously to possess the highest affinities and agonist functional potencies at the serotonin 5-HT_2A receptor among this chemical class. Further, affinity declines when both furanyl rings are expanded to the larger dipyranyl ring system. The ...

A six-month study was conducted by the Technical Measurements Center, US Department of Energy Grand Junction Projects Office, to evaluate the accuracy and reliability of indoor radon measurements using an intermittent diffusion-barrier charcoal canister sampling protocol. Diffusion-barrier charcoal canisters (DBCC) were exposed for seven days in sixteen occupied residences each week during the ...

Tumor necrosis factor alpha (TNFalpha) is a cytokine implicated in the pathogenesis of numerous chronic and acute inflammatory conditions. In the present study, we have characterized the ability of TNFalpha in inducing eosinophil accumulation in rat skin and have shown the inhibitory effects of anti-alpha4 integrin and anti-vascular cell adhesion molecule-1 (VCAM-1) antibodies on this response. ...

Much effort is currently invested in the development of mass spectrometry-based strategies for investigating the entirety of glycosphingolipids (GSLs) of a certain cell type, tissue, organ or body encompassing the respective glycosphingolipidome. As part of the investigation of the vertebrate glycosphingolipidome, GSL analysis is undergoing rapid expansion owing to the application of novel mass ...

Passive and active immunization against outer surface protein A (OspA) has been successful in protecting laboratory animals against subsequent infection with Borrelia burgdorferi. Antibodies (Abs) to OspA convey full protection, but only when they are present at the time of infection. Abs inactivate spirochetes within the tick and block their transmission to mammals, but do not affect established ...

The angiogenic switch is a fundamental process for many diseases and for tumor growth. The main proangiogenic stimulus is hypoxia, through activation of the hypoxia-inducible factor (HIF)-1? pathway in endothelial cells (ECs). We have previously shown that the vasostatin-1 (VS-1) fragment of chromogranin A inhibits TNF-?-induced vessel permeability and VEGF-induced EC proliferation, together with ...

The molecular basis of the HNA-3a/b (5b/a) leukocyte antigen system has not yet been defined despite evidence that HNA-3a�specific antibodies are particularly prone to cause severe, often fatal, transfusion-related lung injury. We used genome-wide single nucleotide polymorphism scanning and sequencing of DNA from persons of different HNA-3a/b phenotypes to identify a single single nucleotide ...

Reactions of N,N;-disubstituted hydrazinecarbothioamides 8a-c and substituted thioureidoethylthioureas 9a-c with 2,3,5,6-tetrachloro-1,4-benzoquinone (chloranil, 10a) and 2,3,5,6-tetrabromo-1,4-benzoquinone (bromanil, 10b) to form N,N;-disubstituted [1,3,4]thiadiazole-2,5-diamines 11a-c, 6,7-dichloro-3-substituted amino-1H-benzo[1,3,4]- thiadiazine-5,8-diones 12a-c, ...

Amidines (guanidine, formamidine, and acetamidine) were introduced as substitutes for the cationic heads present in atropine, scopolamine, and corresponding quaternary derivatives. Amidine systems are intermediate in structure between tertiary amines and quaternary compounds, at least as regards ionization and electronic properties, but differ from the latter in shape (planar not tetrahedral). ...

Cholera is a global disease that has persisted for millennia. The cholera toxin (CT) from Vibrio cholerae is responsible for the clinical symptoms of cholera. This toxin is a hetero-hexamer (AB(5)) complex consisting of a subunit A (CTA) with a pentamer (B(5)) of subunit B (CTB). The importance of the AB(5) complex for pathogenesis is established for the ...

Epitaxial Ni2MnGa and Ni2Mn1.2Ga0.8 thin films have been grown by molecular beam epitaxy on GaAs (001) substrates with Sc0.3Er0.7As interlayers. Structural characterization of as-grown films confirms the epitaxially stabilized single crystal structure of the films and indicates that the films grow pseudomorphically on GaAs (001) substrates in a tetragonal structure (a=b=5.65 �, c=6.18 �). The ...

Using the daily Mt. Wilson Doppler velocity data during 1986�1994 (solar cycle 22), we studied the short-term variations of the order of a few days to a month timescales in the solar differential rotation. We represent the differential rotation in the form: ?(?)=A�+B�(5sin2?-1)+C�(21sin4?-14sin2?+1), using a set of Gegenbauer polynomials, where ?(?) is the angular velocity at latitude ?. ...

We propose to use GMOS-N to carry out long-slit spectroscopic observations to establish a sample of the most luminous Lyman Break Galaxies (LBGs)(22.5AB (5?), using Large Binocular Cameras (LBCs) on the ...

This work explores the potential of iridium complexes of the N-heterocyclic carbene oxazoline ligands 1 in asymmetric hydrogenations of arylalkenes. The accessible carbene precursors, imidazolium salts 2, and robust iridium complexes 5 facilitated a discovery/optimization approach that featured preparation of a small library of iridium complexes, parallel hydrogenation reactions, and automated ...

Three hamster monoclonal antibodies (mAbs), all recognizing different epitopes present on the native form of the murine T-cell antigen receptor (TCR) gamma delta subunits, have been generated. mAb 3A10 is specific to a pan-murine TCR gamma delta, recognizing a C delta constant region determinant. mAb 8D6 is specific to a subset of T cells expressing V gamma 4- and V delta 5-encoded gamma delta ...

Decay accelerating factor (DAF), membrane cofactor protein (MCP), complement receptor 1 and mouse Crry are cell surface-bound complement regulatory proteins capable of inhibiting C3 convertase activity on cell membranes, and therefore provide a substantial protection from attack by homologous complement activated either by the classical or by the alternative pathway. Decrease in complement ...

Murine monoclonal antibodies (mAb) produced against native human thyroid peroxidase (TPO) are powerful tools for analyzing the autoantibody (Aab) epitopes on TPO. Binding sites of thirteen mAbs cover all or most antigenic regions on TPO. We determined the competition between Aabs from 75 AITD patients and 13 mAbs in binding to TPO. Autoantibodies recognize predominantly the TPO area close or ...

BackgroundCD26 is a type II, cell surface glycoprotein known as dipeptidyl peptidase (DPP) IV. Previous studies have revealed CD26 expression in T cell leukemia/lymphoma and malignant mesothelioma, and an inhibitory effect of anti-CD26 monoclonal antibody (mAb) against the growth of CD26+ cancer cells in vitro and in vivo. The function of CD26 in tumor development is unknown and the machinery with ...

We investigate long-term metal resource constraints for large-scale EV systems for nine types of batteries: Li-polymer(V), Li-ion(Mn, Ni and Co), NaNiCl, NiMH(AB 2 and AB 5 ), NiCd and PbA, containing seven potentially scarce metals/group of metals: lithium, nickel, cobalt, vanadium, cadmium, lead and rare-earth elements. As a basis for the analysis, we ...

Missing-self-reactivity can be mimicked by blocking self-specific inhibitory receptors on NK cells, leading to increased rejection of syngeneic tumor cells. Using a mouse model, we investigated whether Ab-mediated blocking of inhibitory receptors, to a degree where NK cells rejected syngeneic tumor cells, would still allow self-tolerance toward normal syngeneic cells. Ly49C/I inhibitory receptors ...

BACKGROUND We explored the relevance of blood type to ovarian reserve, as reflected by early follicular phase FSH levels. METHODS For this cross-sectional observational study, early follicular phase serum levels of FSH (mIU/ml) and estradiol (E2, pg/ml), and information on blood type (A, B, AB and O) and patient age were procured for female patients, ?45 years age (n= 544), who were undergoing ...

The research of novel probiotic strains is important in order to satisfy the increasing request of the market and to obtain functional products in which the probiotic cultures are more active and have better probiotic characteristics than those already on the market. In this study, the probiotic potential of Lactobacillus and Enterococcus strains isolated from human feces was investigated. One ...

Some shiga toxin-producing Escherichia coli secrete a novel AB5 cytotoxin, named subtilase cytotoxin (SubAB), which induces vacuole formation in addition to cytotoxicity in susceptible cells. By immunoprecipitation with SubAB from Vero cells, we discovered proteins of 100 kDa, 135 kDa and 155 kDa as potential candidates for its receptor. These proteins ...

Hyoscyamine 6 beta-hydroxylase (H6H; EC 1.14.11.11) catalyzes the first reaction in the biosynthetic pathway from hyoscyamine to scopolamine in several solanaceous plants. Four monoclonal antibodies were raised against H6H purified from cultured roots of Hyoscyamus niger. The IgG1 antibody mAb5 inhibited H6H activities present in cell-free extracts of H. ...

Southeastern Ohio has been extensively coal mined. The coal in this region and associated rocks are high in sulfur and generate acid mine drainage when exposed to air and water. Poor water quality in rivers and streams is a common problem in this region. Water recharge to the underground coal mines occurs preferentially throughout subsidence features in areas where the overburden is thinner than ...

BACKGROUND: Immunoglobulins (IVIG) have been shown to be useful in adults suffering from sepsis. In contrast, prophylactic and curative IVIG trials failed to show beneficial effects in neonates. We tested the hypothesis that IVIG, have different effects on monocytes from cord blood (CBMO) and peripheral blood monocytes from adults (PBMO) with respect to survival, phenotype, and function. METHODS: ...

The appearance of serum levels of circulating cathodic antigen (CCA) detectable by a monoclonal antibody (mAb) (5H11) antigen-capture sandwich enzyme-linked immunosorbent assay (ELISA) system was evaluated during acute Schistosoma mansoni infections in female CF1 mice exposed to either 100 or 25 cercariae. Measurable CCA levels occurred in these groups at ...

The crystal structure of Ca{sub 5}Nb{sub 5}O{sub 17}, an n=5 member of the homologous series A{sub n}B{sub n}O{sub 3n+2}, at room temperature has been determined by single-crystal X-ray diffraction using synchrotron radiation with a CCD area detector. The structure is monoclinic with spacegroup P2{sub 1}/c (b unique) and lattice parameters a=7.7494(3) A,b=5.4928(1) A,c=32.241(1) A,and ...

OBJECTIVE: To evaluate the aesthetic colour performance (colour blending) of plastic and ceramic brackets by determining the colour changes of shade guide tabs before and after bracket placement. DESIGN: In vitro, laboratory study. MATERIALS AND METHODS: Four plastic and four ceramic brackets were investigated (n?=?5). Brackets were placed on the labial surface of the A1 and A4 tabs of a Vitapan ...

We present the results of a systematic search for gravitationally lensed continuum Lyman break ``dropouts'' beyond a redshift 7 conducted via very deep imaging through six foreground clusters undertaken with the Hubble and Spitzer space telescopes. The survey has yielded 10 z-band and two J-band dropout candidates to photometric limits of J110~=26.2 AB (5 ...

Volga mouth region is investigated much better, than sea mouths of other river in Russia. In spite of the fact, not enough attention was devoted to Volga shallow offing. Volga shallow offing covers area about 9,3 ths. sq. km and has great significance for Caspian sea fish industry, because environmental conditions of this region and neighboring shallows of Northern Caspian Sea are determinative ...

Introduction.? Hyperprolactinemia (hyperPRL)-related hypogonadism or suppression of human chorionic gonadotropin (hCG)-induced testosterone (T) release is hypothesized to be mediated by a testicular interstitial macrophage and tumor necrosis factor alpha (TNF-?)-involved blockage. Aim.? To test if the lower T response after hCG challenge in the hyperPRL rats is reversed by administrating ...

In this dissertation, I study the co- and postseismic deformation of the lithosphere using numerical models of three-dimensional time-dependent deformation and space geodetic data. I derive an original approach to simulate the static deformation due to faulting and volcanic unrest in a heterogeneous half space with vertical and lateral variations in elastic moduli. The method is based on a ...

BackgroundCockroach allergy is strongly associated with asthma, and involves the production of IgE antibodies against inhaled allergens. Reports of conformational epitopes on inhaled allergens are limited. The conformational epitopes for two specific monoclonal antibodies (mAb) that interfere with IgE antibody binding were identified by X-ray crystallography on opposite sites of the ...

The 49-residue functional upstream domain (FUD) of Streptococcus pyogenes F1 adhesin interacts with fibronectin (FN) in a heretofore unknown manner that prevents assembly of a FN matrix. Biotinylated FUD (b-FUD) bound to adsorbed FN or its recombinant N-terminal 70-kDa fibrin- and gelatin-binding fragment (70K). Binding was blocked by FN or 70K, but not by fibrin- or gelatin-binding subfragments ...

We earlier developed a MoAb, 7E12H12 (IgM isotype), against a protein present in normal colonic epithelial cells. To examine if 7E12H12-reactive protein is expressed in colon cancer cells and is recognized by ulcerative colitis (UC)-associated autoantibody, we investigated several colon cancer cell lines. 7E12H12 reactivity against the cells was examined ...

We earlier developed a MoAb, 7E12H12 (IgM isotype), against a protein present in normal colonic epithelial cells. To examine if 7E12H12-reactive protein is expressed in colon cancer cells and is recognized by ulcerative colitis (UC)-associated autoantibody, we investigated several colon cancer cell lines. 7E12H12 reactivity against the cells was examined ...

Phosphatidylethanolamine binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein (RKIP), has been considered as a suppressor of metastasis and a prognostic marker in prostate cancer, breast cancer, gastrointestinal stromal tumors, melanoma, and epithelial ovarian cancer. In this report, recombinant PEBP1 was successfully expressed in an Escherichia coli system. A panel of monoclonal ...

Ulcerative colitis (UC) has a proposed autoimmune pathogenesis. A 40-kD antigen (P40) has been isolated from UC colon, bound to immunoglobulin. Tropomyosin has been reported as the target antigen of a MoAb (7E12H12) raised against P40. We set out to investigate whether tropomyosin is the major antigenic determinant for 7E12H12. Formalin-fixed, ...