The ATP-binding cassette (ABC) transporter ABCB6 is a mitochondrial porphyrin transporter that activates porphyrin biosynthesis. ABCB6 lacks a canonical mitochondrial targeting sequence but reportedly traffics to other cellular compartments such as the ...
PubMed
The porphyrins (such as heme) are essential molecules within cells and have multiple roles in essential cellular processes such as: the mitochondrial electron transport chain, free-radical detoxification, and metabolism. The porphyrins need energy to traverse biological membranes. Our understanding of ABC transporters role in ...
ATP-binding cassette (ABC) transporters regulate the transport of a variety of physiologic substrates. Moreover, several human ABC proteins are responsible for drug exclusion in compound-treated tumor cells, providing cellular mechanisms for the development of multidrug resistance and, therefore, playing an ...
ATP-binding cassette (ABC) transporters are drug efflux pumps responsible for the multidrug resistance phenotype causing hepatocellular carcinoma (HCC) treatment failure. Here we studied the expression of 15 ABC transporters relevant for multidrug resistance in 19 paired HCC patient samples (16 untreated, 3 treated ...
Table 1. Clinically relevant and atypical ABC proteins Kenneth J. Linton. Structure and Function of ABC Transporters. Physiology 22: 122-130, 2007
NSDL National Science Digital Library
Expression of the ATP-binding cassette transporter ABCB6 has been associated with multiple cellular functions, including resistance to several cytotoxic agents, iron homeostasis, and porphyrin transport. To further elucidate its physiological function and/or role in drug resistance, we determined the subcellular ...
). #12;Chapter 1 2.2. Binding protein dependent ABC- type transporters The sugar transporters characterized so, and Rad50cd, a DNA repair protein which shows ATP-binding domains similar to the domains found in ABC-transporters a binding protein-dependent ATP- binding cassette (ABC)-transporter ...
E-print Network
-binding proteins (SBPs) of ATP Binding Cassette (ABC) transporters has been ongoing for at least four decades. Our on the lactococcal oligopeptide binding protein A (OppA), the receptor component of the ABC-transporter oligopeptide picture how these proteins work. Three types of ABC-transporters exist: ...
posterior probability) and sequences from human (ABCB1, ABCB4, ABCB5, and ABCB11) and the bivalve_000535.3; ABCB4, NP_000434.1; ABCB5, NP_848654.3; ABCB6, NP_005680.1; ABCB7, NP_004290.2; ABCB8, NP). ThPgpisoform 2 and CgPgpisoform1 clusters with human ABCB1, ABCB4, ABCB5 and ABCB11 genes. ABCB1 (MDR
of SBP-dependent membrane proteins. A-B: visualizes ABC- transporters. A: ABC-importer with the SBP dependent transport proteins ABC-transporters exist in all three kingdom of life and transport a large of the membrane protein. In mGluR this signal is triggered by ligand ...
Etravirine is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV-1 infections. ABC transporters potentially mediate clinically relevant drug-drug interactions. We assessed substrate characteristics and the inhibitory and inductive potential of etravirine on ABC transporters. ...
FIGURE 1. The minimal ABC transporter has four domains. Two transmembrane domains (TMDs) bind ligand, and transport is driven by ATP binding and hydrolysis by the two nucleotide binding domains (NBDs). The TMDs from different subfamilies of ABC transporters are not necessarily homologous. The ...
