The human ABCB1 protein, (P-glycoprotein or MDR1) is a membrane-bound glycoprotein that harnesses the energy of ATP hydrolysis to drive the unidirectional transport of substrates from the cytoplasm to the extracellular space. As a large range of therapeutic agents are known substrates of ABCB1 protein, its role in the onset of multidrug resistance has been ...
PubMed
Homology modelling was used to generate three-dimensional structures of the nucleotide-binding domains (NBDs) of human ABCB1 and ABCG2. Interactions between a series of steroidal ligands and transporter NBDs were investigated using an in silico docking approach. C-terminal ABCB1 NBD ...
The human ATP-binding cassette (ABC) transporters ABCB1, ABCC4 and ABCC5 are involved in resistance to chemotherapeutic agents. Here we present molecular models of ABCB1, ABCC4 and ABCC5 by homology based on a wide open inward-facing conformation of Escherichia coli MsbA, which were constructed in order to elucidate differences in the electrostatic and ...
PubMed Central
The human ATP-binding cassette (ABC) transporter, P-glycoprotein (P-gp; ABCB1), mediates the ATP-dependent efflux of a variety of drugs. As a result, P-gp plays a critical role in tumor cell drug resistance and the pharmacokinetic properties of most drugs. P-gp exhibits extraordinary substrate and inhibitor promiscuity, resulting in a wide range of ...
Multidrug ABC transporters such as P-glycoprotein (P-gp/MDR1/ABCB1) and multidrug resistance protein 1 (MRP1/ABCC1) play an important role in the extrusion of drugs from the cell and their overexpression can be a cause of failure of anticancer and antimicrobial chemotherapy. Recently, the mouse P-gp/Abcb1a ...
... Descriptors : (*FERROELECTRIC CRYSTALS, *CRYSTAL STRUCTURE), (*GUANIDINES, CRYSTAL STRUCTURE), (*ALUMINUM COMPOUNDS ...
DTIC Science & Technology
... Descriptors : *CRYSTAL OSCILLATORS, *QUARTZ, CLEANING, CRYSTAL GROWTH, CRYSTAL DEFECTS, CRYSTAL STRUCTURE, ETCHED ...
... AND SILICON CRYSTAL FACES UNDER CZOCHRALSKI'S ... CRYSTAL GROWTH, CRYSTAL STRUCTURE, CRYSTALS. ...
... Descriptors : *CRYSTALS, *GERMANIUM COMPOUNDS, *THORIUM COMPOUNDS, ALLOYS, CRYSTAL LATTICES, CRYSTAL STRUCTURE ...
The efflux pumps ABCB1 (p-gp, MDR1) and ABCG2 (BCRP) are expressed to a high extent by endothelial cells at the blood-brain barrier (BBB) and other barrier tissues and are involved in drug resistance of tumor (stem) cells. Whereas numerous ABCB1 inhibitors are known, only a few ABCG2 modulators with submicromolar ...
... Descriptors : (*MAGNESIUM, CRYSTAL STRUCTURE), (*CRYSTAL STRUCTURE ... PHASE STUDIES, SINGLE CRYSTALS, FOURIER ...
... Descriptors : *TELLURIUM COMPOUNDS, *ORGANOMETALLIC COMPOUNDS, CRYSTAL STRUCTURE, CRYSTAL STRUCTURE, BROMIDES ...
... THE CRYSTAL AND MOLECULAR STRUCTURE OF ORTHORHOMBIC SULFUR ... The Crystal and Molecular Structure of Orthorhombic Sulfur by ...
... energy structure. Descriptors : *CRYSTAL STRUCTURE, *FLUORINE COMPOUNDS, SINGLE CRYSTALS, GUANIDINES. ...
P-glycoprotein (Pgp; ABCB1), a member of the ATP-binding cassette (ABC) superfamily, exports structurally diverse hydrophobic compounds from the cell, driven by ATP hydrolysis. Pgp expression has been linked to the efflux of chemotherapeutic drugs in human cancers, leading to multidrug resistance (MDR). The protein also plays an ...
... THE EVALUATION OF LATTICE INTERACTIONS IN OR NEAR A CUBIC CRYSTAL. ... CRYSTALS, CRYSTAL LATTICES, CRYSTAL STRUCTURE ...
... Descriptors : *SINGLE CRYSTALS, CRYSTAL LATTICES, CRYSTAL STRUCTURE, CRYSTALS, DEFORMATION ... ALLOYS, MAGNESIUM ALLOYS ...
... CRYSTALS, *DEFORMATION, *METAL CRYSTALS, *METALS, ALUMINUM, CRYSTAL LATTICES, CRYSTAL STRUCTURE, ELASTIC ...
... Descriptors : (*FERROELECTRIC CRYSTALS, PHYSICAL PROPERTIES), CRYSTAL GROWTH, CRYSTAL STRUCTURE, SINGLE CRYSTALS ...
... Descriptors : *CRYSTAL STRUCTURE, *CRYSTAL DEFECTS, *CRYSTAL GROWTH, YTTRIUM ALUMINUM GARNET, TEMPERATURE, LAYERS ...
... Descriptors : *CRYSTALS, CRYSTAL LATTICES, CRYSTAL STRUCTURE, GROWTH(PHYSIOLOGY), PHYSICAL PROPERTIES, PURIFICATION ...
... Descriptors : , (*ICE, CRYSTAL GROWTH), (*CRYSTAL GROWTH, ICE), FREEZING, CRYSTAL STRUCTURE, CONTROLLED ATMOSPHERES. ...
... MATERIALS, *PIEZOELECTRIC CRYSTALS, *SPINEL, CHEMICAL BONDS, CRYSTAL LATTICES, CRYSTAL STRUCTURE, DIELECTRIC ...
... CRYSTAL LATTICES, CRYSTAL STRUCTURE, CRYSTALS, HYPERFINE STRUCTURE, INFRARED SPECTROSCOPY, IODIDES, IONS, MOTION ...
... Descriptors : (*CRYSTAL STRUCTURE, *MOLECULAR ASSOCIATION), (*HALOGENATED HYDROCARBONS, CRYSTAL STRUCTURE), X RAY ...
... Descriptors : *CRYSTAL LATTICES, *CRYSTAL STRUCTURE, *CRYSTALS, *SULFIDES, *ZINC COMPOUNDS, BRILLOUIN ZONES, DIELECTRIC ...
... Crystalline structures of elements not governed by ... valence molecular crystals with the ... Descriptors : (*CRYSTAL STRUCTURE, *ATOMIC ORBITALS ...
... Descriptors : (*MOLECULAR ORBITALS, CRYSTAL LATTICES), (*CRYSTAL DEFECTS, CRYSTAL STRUCTURE), ZEEMAN EFFECT, ROTATION ...
... made of how the principal faces, namely, the ... Descriptors : *DIAMONDS, CRYSTAL STRUCTURE, CRYSTALS, ATOMIC STRUCTURE ...
... Descriptors : *CRYSTAL STRUCTURE, *HYDRATES, *SILICATES, *GUANIDINES, CATIONS, REMOVAL, WATER, SINGLE CRYSTALS, ...
... Descriptors : *CARBIDES), (*MOLYBDENUM COMPOUNDS, (*SINGLE CRYSTALS, CRYSTAL STRUCTURE), PHASE STUDIES, DENSITY, X ...
... Descriptors : (*IRON OXIDES, *CRYSTAL GROWTH), (*GRAIN STRUCTURES( METALLURGY), IRON OXIDES), CRYSTAL STRUCTURE ...
... MATERIALS, ATOMIC STRUCTURE, CHEMICAL BONDS, COMPLEX COMPOUNDS, CRYSTAL LATTICES, CRYSTAL STRUCTURE, CRYSTALS ...
The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant cancer cells is a serious impediment to chemotherapy. MDR1 is expressed in various tissues to protect them from the adverse effect of toxins. The pharmacokinetics of drugs that are also ...
... CRYSTAL STRUCTURE), (*CHLORINE COMPOUNDS, CRYSTAL STRUCTURE), FLUORIDES, CHEMICAL BONDS, MOLECULAR STRUCTURE ...
