The ATP-binding cassette transporter G1 (ABCG1) mediates free cholesterol efflux onto lipidated apolipoprotein A-I (apoA-I) and plays an important role in macrophage reverse cholesterol transport thereby reducing atherosclerosis. However, how ...

BackgroundPatients with Type 2 diabetes are at increased risk for the development of atherosclerosis. A pivotal event in the development of atherosclerosis is macrophage foam cell formation. The ABC transporters ABCA1 and ABCG1 regulate macrophage cholesterol efflux, and hence play a vital role in macrophage foam cell formation. We have previously found ...

... normal group. This finding suggests that in atherosclerosis the reserve cholesterol transport capacity is not diminished. This ...