... Abstract : Endogenous nitric oxide (NO) produced by three ... NOS (iNOS/NOS2), a NOS isozyme, has ... factor (VEGF), to exert its effect in accelerating ...
DTIC Science & Technology
Using Western blot and fluorescent immunocytochemistry, NOS III (or ecNOS) and NOS II (or iNOS), but no NOS I (or ncNOS), were identified in preparations of human platelets. Reverse-transcription polymerase chain reactions (RT-PCR) demonstrated NOS III ...
PubMed
There are currently four known isoforms of nitric oxide synthase (NOS). Of these, neuronal NOS (nNOS) is known to be present exclusively in neurons, endothelial NOS (eNOS) in vascular endothelium, while the inducible form of NOS (iNOS) is known to be ...
... Neurobiology of Sleep and Sleep Treatments in PTSD (NOS-STIP) ... PT073961: Neurobiology of Sleep and Sleep Treatments in PTSD (NOS-STiPj ...
St. Lucia St. Vincent and The Grenadines Trinidad and Tobago Turks Islands Antilles, NOS West Indies, NOS Windward Islands, NOS 246 Bermuda 247 Bahamas, The 249 St.
Cancer.gov
Nitric oxide synthase (NOS) produces nitric oxide (NO) from arginine. Three NOS isoforms have been identified in mammals, namely a neuronal (NOS1), an inducible (NOS2) and an endothelial (NOS3) enzyme. In zebrafish genome, one nos1 gene and two nos2 ...
Nitric oxide synthase (NOS) expression and catalytic status in human peripheral blood mononuclear cells (PBMCs) is debatable, while its sub-cellular distribution remains unascertained. The present study characterizes NOS transcripts by real time PCR, NOS protein by immunoprecipitation (IP)/Western blot (WB), nitric oxide (NO) ...
In mammals, endothelial nitric oxide synthase (eNOS) has the weakest activity, being one-tenth and one-sixth as active as the inducible NOS (iNOS) and the neuronal NOS (nNOS), respectively. The basis for this weak activity is unclear. We hypothesized that a hinge element that connects the FMN ...
PubMed Central
... Title : 19302A GSRS. Missile Nos. V-10, V-11 and V-12 Round Nos. 11, 12 and 10 (28 August 1978). Descriptive Note : Meteorological data rept. ...
... Title : 16101 Little John, Missile Nos. 3131/3117, Round Nos. 701 RO/702 RO--(13 November 1973). Descriptive Note : Meteorological data rept. ...
... Title : 14810A Lance, Missile Nos. 2559/2561, Round Nos. 231 APT/232 APT (11 July 1974). Descriptive Note : Meteorological data rept. ...
... Title : 14808/14807 Lance Missile Nos. 2984/2987 Round Nos. 256 APT/257 APT (6 December 1974). Descriptive Note : Meteorological data rept. ...
... Title : 14805/14806 Lance Missile Nos. 2213/2232 Round Nos. 259 APT/260 APT (13 February 1975). Descriptive Note : Meteorological data rept. ...
... Title : 14805 Lance Missile Nos. 2229/2231 Round Nos. 244 APT/245 APT (17 October 1974). Descriptive Note : Meteorological data rept. ...
... Title : 14804/14808 Lance Missile Nos. 2977/2978 Round Nos. 252 APT/253 APT (5 December 1974). Descriptive Note : Meteorological data rept. ...
... Title : 14804 Lance, Missile Nos. 2191/2187, Round Nos. 199 APT/200 APT. Descriptive Note : Meteorological data rept. ...
... Title : 14804 Lance Missile Nos. 2201/2208 Round Nos. 205 APT/206 APT (24 January 1974). Descriptive Note : Meteorological data rept. ...
... Title : 14803 Lance Missile Nos. 2598/2599 Round Nos. 248 APT/249 APT (15 November 1974). Descriptive Note : Meteorological data rept. ...
... Title : 14802 Lance Missile Nos. 2225/2221 Round Nos. 242 APT/243 APT (10 October 1974). Descriptive Note : Meteorological data rept. ...
... Title : 14801/07 Lance, Missile Nos. 2565/2566, Round Nos. 217 APT/218 APT (18 April 1974). Descriptive Note : Meteorological data rept. ...
... Title : 14801 Lance, Missile Nos. 2224/2228, Round Nos. 240 APT/241 APT. (3 October 1974). Descriptive Note : Meteorological data rept. ...
... Title : 14801 Lance, Missile Nos. 2207/2190, Round Nos. 197 APT/198 APT (4 October 1973). Descriptive Note : Meteorological data rept. ...
... Title : 14801 Lance, Missile Nos. 2195/2198, Round Nos. 194 APT/195 APT (26 September 1973). Descriptive Note : Meteorological data rept. ...
... Title : 14801 Lance Missile Nos. 2476/2563 Rounds Nos. 313 APT/214 APT (11 April 1974). Descriptive Note : Meteorological data rept. ...
... Title : 14801 Lance Missile Nos. 2217/2218 Round Nos. 212 APT/213 APT (4 April 1974). Descriptive Note : Meteorological data rept. ...
The inhibition of neuronal and inducible nitric oxide synthases (nNOS and iNOS) by a series of 36 indazoles has been evaluated, showing that most of the assayed derivatives are better iNOS than nNOS inhibitors. A parabolic model relating the iNOS inhibition percentage with the difference, ...
BackgroundNitric oxide generated by neuronal (NOS1), inducible (NOS2) or endothelial (NOS3) nitric oxide synthases contributes to pain processing, but the exact role of NOS1 and NOS2 in the maintenance of chronic peripheral neuropathic pain as well as the possible compensatory changes in their ...
Nitric oxide synthase (NOS) inhibitors induce chronic lymphocytic leukemia (CLL) cell apoptosis and have potential as CLL therapeutics. We determined the half-maximal concentration (ED(50)) of 22 NOS inhibitors that induced CLL cell death in vitro. There was a direct correlation of the NOS1 (but not NOS2) ...
Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation. NO is a reactive oxygen species as well as a reactive nitrogen species. It is a free radical which mediates several biological effects. It is clear that the generation and actions of NO under physiological and pathophysiological conditions are regulated and extend to almost every cell ...
The rupture of cerebral aneurysm (CA) and subsequent subarachnoid hemorrhage can cause fatal results. Recent experimental findings have suggested that the mechanism of CA formation is based on chronic inflammation in arterial walls by hemodynamic force. Endothelial nitric oxide synthase (eNOS) protects arterial walls from vascular inflammation by relieving hemodynamic force ...
Science teachers need an adequate understanding of nature of science (NOS) and the ability to embed NOS in their teaching. This collective case study aims to explore in-service science teachers' conceptions of NOS and the embeddedness of NOS in their teaching about astronomy and space. Three science teachers ...
NASA Astrophysics Data System (ADS)
Nitric oxide (NO), a mediator of various physiological and pathophysiological processes, is synthesized by three isozymes of nitric oxide synthase (NOS). Potential candidate clinical drugs should be devoid of inhibitory activity against endothelial NOS (eNOS), since eNOS plays an important role in maintaining ...
BackgroundThe importance of nitric oxide (NO) in hypoxic pulmonary hypertension has been demonstrated using nitric oxide synthase (NOS) knockout mice. In that model NO from endothelial NOS (eNOS) plays a central role in modulating pulmonary vascular tone and attenuating hypoxic pulmonary hypertension. However, the normal regulation of ...
Background. Acute peritonitis is the most frequent complication of peritoneal dialysis (PD). Increased nitric oxide (NO) release by NO synthase (NOS) isoforms has been implicated in acute peritonitis, but the role played by the NOS isoforms expressed in the peritoneum is unknown.Methods. We investigated the structural and functional consequences of acute ...
Chronic liver disorders represent a serious health problem, considering that 300 million people worldwide are hepatitis B virus carriers, and 8,000�10,000 patients per year, in the U.S. alone, die as a result of liver failure caused by hepatitis C infection. Nitric oxide synthase (NOS) regulates hepatic vasculature; however, the patterns of expression and activity of ...
Bulgac-Kusnezov-Nos�-Hoover thermostats Alessandro Sergi* School of Physics, University of Kwa additional Nos� variable, and another where each demon is coupled to an independent Nos�-Hoover thermostat the simple Bulgac-Kusnezov thermostat is apparently not ergodic, both of the Nos�-Hoover controlled ...
E-print Network
Objectives and Design. The function of the airway nitric oxide synthase (NOS) isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflammation, which requires upregulation, of NOS2 protein expression by an NOS3-dependent ...
Polymorphisms in the human endothelial nitric oxide synthase (eNOS) gene (NOS3) have been associated with advanced nephropathy in diabetic patients and with decreased expression in tissue culture. However, direct proof that modest genetic decreases in eNOS expression worsen diabetic nephropathy is lacking. To investigate this effect, ...
There is evidence that inducible nitric-oxide synthase (iNOS)-derived NO contributes to the pathophysiology of intestinal inflammation. The aims of this study were to assess the role of iNOS in the development of dextran sodium sulfate (DSS)-induced colonic inflammation and to define the contribution of tissue-specific iNOS expression ...
Signaling via the neuronal NOS (nNOS) splice variant nNOS? is essential for skeletal muscle health and is commonly reduced in neuromuscular disease. nNOS? is thought to be the predominant source of NO in skeletal muscle. Here we demonstrate the existence of what we believe to be a novel signaling pathway, mediated ...
Nitric oxide (NO) protection is crucial against angiotensin II (ANG II) mediated vasoconstriction in postnatal preglomerular resistance vessels. While whole kidney nitric oxide synthase (NOS) is developmentally regulated, NOS regulation in developing renal resistance vessels is unknown. The hypothesis was NOS expression and function in ...
Nitric oxide (NO) participates in the neural pathways controlling the lower urinary tract (LUT). Expression of NO synthase (NOS) can be upregulated after spinal cord injury (SCI), and altered NOS activity may participate in resulting LUT dysfunction. To investigate distribution of NOS-immunoreactivity (NOS-IR) in ...
Nautical Charts available from National Ocean Service (NOS) Marine Chart Division ... available from MapTech, NOS' marketing partner for raster nautical ...
NASA Website
... 15 (33) 6 (0.8) Combined bronchitis [1] 14 (30) 9 (1) ... [1] Includes reported preferred terms of Bronchiectasis NOS, Bronchitis NOS, and Bronchitis acute NOS. ...
Center for Biologics Evaluation and Research (CBER)
The etiological role of the gene for neuronal nitric oxide synthase (NOS1) in infantile pyloric stenosis (PS) was investigated by analysis of two intragenic polymorphisms (NOS1a and NOS1b) in 27 families. There was significant overall transmission disequilibrium between PS and NOS1a (P = .006). Consideration of ...
The etiological role of the gene for neuronal nitric oxide synthase (NOS1) in infantile pyloric stenosis (PS) was investigated by analysis of two intragenic polymorphisms (NOS1a and NOS1b) in 27 families. There was significant overall transmission disequilibrium between PS and NOS1a (P=.006). Consideration of each ...
Energy Citations Database
Ca2+-dependent and Ca2+-independent nitric oxide synthase (NOS) activity, and neuronal and inducible NOS immunoreactivity (nNOS-IR and iNOS-IR), were investigated in the rabbit lower lumbar spinal cord after i) sciatic nerve transection and survival of experimental animals for 2 weeks, ii) treatment of animals with ...
Figure 3: The relative abundance of the endothelial NOS protein and the neuronal NOS protein in homogenates of renal cortex. Legend: The relative abundance of the endothelial NOS (eNOS) protein (top) and the neuronal NOS (nNOS) protein in homogenates of renal cortex from ...
NSDL National Science Digital Library
Uncoupling of nitric oxide synthase (NOS) has been implicated in left ventricular (LV) remodeling and dysfunction after myocardial infarction (MI). We hypothesized that inducible NOS (iNOS) plays a crucial role in LV remodeling after MI depending on its coupling status. MI was created in wild-type (WT), ...
... tory, Bar Harbor, ME) were studied in a ... Many studies have suggested a close relationship between NOS ... part of funding for this study and assisted ...
BACKGROUND: Nitric oxide (NO) has been implicated as a mediator of penile erection, because the neuronal isoform of NO synthase (NOS) is localized to the penile innervation and NOS inhibitors selectively block erections. NO can also be formed by two other NOS isoforms derived from distinct genes, inducible NOS ...
... Accession Number : ADA537223. Title : Neurobiology of Sleep and Sleep Treatments in PTSD (NOS-STIP). Descriptive Note : Annual rept. ...
... Accession Number : AD0299772. Title : NUCLEAR ENERGY, 1962, VOL. 5, NOS. 4-6: (SELECTED) ARTICLES. Corporate ...
Report describes methods and costs of mining uranium at Calyx Nos. 3 and 8 mines on the Colorado plateau.
... paper indexes, and related products are available from NOS Coast Survey and its worldwide network ... NOS' marketing partner for raster nautical charts. ...
... variables, two NOS-related factors affect job satisfaction. Respondents who work in their primary NOS are sore satisfied with their jobs than those ...
Nitric oxide (NO) is an important molecular messenger regulating the functions of a wide variety of cells and tissues. NO is synthesized from L-arginine by a variety of isoforms of the enzyme nitric oxide synthase (NOS). The authors have used Southern blotting analysis on DNAs obtained from a panel of human-rodent hybrid cell lines to map the gene encoding the inducible ...
... Accession Number : AD0844072. Title : Journal of Inorganic and General Chemistry, Vol. 342, Nos. 1-2, 1966 (Selected Articles),. ...
... NOS Germany GM Germany, Federal Republic of GE Germany, Berlin ... NOS Germany, Federal Republic of GE Germany, Federal Republic of GE ...
... AD0773627. Title : Hydraulic Constants of Tidal Entrances I: Data from NOS Tide Tables, Current Tables and Navigation Charts. ...
Where present, USACE survey data supplant NOS hydrographic sounding data values in ... Recent, GPS-navigated NOS, and USACE surveys (primarily in dredged ...
... Accession Number : AD0410707. Title : FISHING INDUSTRY PLENUMS NOS. 6-7 ON RESEARCH IN THE WESTERN ...
... Title : Cumulative Author Index for Soviet Laser Bibliographies, Nos. ... Corporate Author : INFORMATICS INC ROCKVILLE MD. ...
... ADA243766. Title : Comparison of AFITPAC versus NOS and a Packet Radio Network Design. Descriptive Note : Master's thesis,. ...
... functions. A family of nitrogen oxide synthases, cNOS and iNOS, catalyze NO generation from L-arginine to L-citrulline. ...
... Accession Number : AD0410604. Title : CHINESE JOURNAL OF SURGERY, 1962, VOL. 10, NOS. 5-7: TABLE OF CONTENTS. ...
... Accession Number : ADA195315. Title : CDC NOS/BE NETED Reference Manual. Descriptive Note : Final rept.,. Corporate ...
... ON /) BATTALION ANTI-TANK PROJECT * -UNDER \\\\ \\\\% j ,Contract Nos. DA-33-019-0RD-3 ... ON BATTALION ANTI -TANK PROJECT Contract Nos. ...
Nitric oxide (NO) is responsible for nitrergic neurotransmission in the gut and its release is dependent on its de novo synthesis by nNOS (neuronal nitric oxide synthase). The magnitude of NO synthesis and release during neurotransmission may be related to the fraction of catalytically active nNOS out of a larger pool of inactive nNOS ...
... Accession Number : AD0617713. Title : ATOLL RESEARCH BULLETIN, NOS. 109-112,. Corporate Author : NATIONAL ACADEMY ...
... 19, NOS. 8-9: TABLE OF CONTENTS (AND ABSTRACTS ... SPECTRUM ANALYZERS, FERMIONS, RARE EARTH ELEMENTS, NUCLEAR ENERGY ...
Two PCR primer sets for the nitrous oxide reductase gene (nosZ) were developed. The initial primers were based on three sequences in GenBank and used to amplify nosZ from continental shelf sediments and from two denitrifiers in culture, Thiosphaera pantotropha and Pseudomonas denitrificans. Three unique marine sediment nosZ genes were ...
Nitric oxide (NO) is a free radical and produced from L-arginine by nitric oxide synthase (NOS). Since NO is recently suggested to be involved in olfactory perception, the expression of eNOS, an isoform of NOS, was examined in the rat olfactory epithelium. The activity of NADPH-diaphorase was also examined as a marker of ...
Although teacher educators have achieved some success in improving teachers' understanding of the nature of science (NOS), helping teachers teach NOS has proved a much greater challenge. Currently, there are few examples in the literature of teachers who effectively teach NOS, and fewer still that rely on student outcomes as a measure ...
ERIC Educational Resources Information Center
Establishing literacy in science is often linked to building knowledge about the Nature of Science (NOS). This paper describes and evaluates an inservice program designed to build elementary teachers� understanding of NOS and an awareness of how NOS impacts science classroom instruction. Data sources consisted of surveys, action ...
Neuronal nitric oxide synthase (nNOS), which is abundantly expressed in the macula densa cells, attenuates tubuloglomerular feedback (TGF). We hypothesize that splice variants of nNOS are expressed in the macula densa, and nNOS-? is a salt-sensitive isoform that modulates TGF. Sprague-Dawley rats received a low-, normal-, or high-salt ...
Nitric oxide (NO) production by vascular endothelium is important in regulation of blood flow. Reduced production of NO can adversely affect blood flow and other vascular functions. We investigated the expression of three nitric oxide synthase (NOS) isoforms in retina and choroid of aged human eyes and eyes with AMD.Alkaline phosphatase immunohistochemistry was performed using ...
1. Uncoupling of nitric oxide synthase (NOS) has been implicated in the pathogenesis of left ventricular (LV) dysfunction in diabetes mellitus. In the present study, we investigated the role of NOS uncoupling in oxidative/nitrosative stress and LV dysfunction in the diabetic mouse heart. 2. Diabetes was induced in wild-type (WT), endothelial (e) ...
Nitric oxide (NO) is an important vasoactive molecule produced by three NO synthase (NOS) enzymes: neuronal (nNOS), inducible (iNOS), and endothelial NOS (eNOS). While eNOS contributes to blood vessel dilation that protects against the development of hypertension, ...
Endothelial nitric oxide synthase (eNOS) has been reported to associate with globular actin, and this association increases eNOS activity. Adenosine, histamine, salbutamol and thrombin cause activation of eNOS through widely different mechanisms. Whether these eNOS agonists can regulate eNOS ...
