BACKGROUND: Platinum resistance constitutes a therapeutic challenge in the treatment of ovarian cancer, with overall unsatisfactory response rates to standard chemotherapy and correspondingly low survival. Regional abdominal hyperthermia and bevacizumab are treatment options that have both shown the capacity to improve the results of standard chemotherapy ...

From October 1980 through December 1982, 46 patients were entered into a pilot study at the University of Utah Medical Center to assess the feasibility and safety of heating deep-seated, advanced, pelvic and abdominal malignancies with an annular array of electromagnetic wave (EMW) applicators. The patients, most of whom were heavily pretreated, were treated on a protocol in ...

From October 1980 through December 1982, 46 patients were entered into a pilot study at the University of Utah Medical Center to assess the feasibility and safety of heating deep-seated, advanced, pelvic and abdominal malignancies with an annular array of electromagnetic wave (EMW) applicators. The patients, most of whom were heavily pretreated, were treated on a protocol in ...

Yeast cells were submitted to hyperthermia either before or after irradiation. The patterns of postradiation recovery were investigated. The enhancement of radiosensitivity by hyperthermia was discussed.

The invention relates to an apparatus for hyperthermia treatment which comprises a combination hyperthermia unit/MRI probe. Moreover, the invention also relates to an MRI apparatus which utilizes the combination hyperthermia unit/MRI probe disclosed herei...

One kind of therapy for treatment of cancer is the use of either systemic or regional hyperthermia combined with chemotherapy. Use of this combination of hyperthermia and chemotherapy has several bases: tumor cells appear to be more sensitive to heat than...

... of hyperthermia combined with a number of anti-cancer drugs, including cisplatin, mitomycin C, bleomycin and peplomycin (2� ... 44:4853�4856.1984. Engelhardt, R. Hyperthermia and drugs. Recent Results Can...

, and the cell-survival curve for ionizing radiation alone was obtained. When combining hyperthermia a spectrophotometer. Cell- survival curves were generated and compared to cell-kill by both hyperthermia and radiation. Cell-survival curves for hyperthermia were obtained by varying the temperature in the incubator

BACKGROUND: : A guideline is provided for the implementation of regional deep hyperthermia treatments under strict rules of quality assurance. The objective is to guarantee a comparable and comprehensible method in the treatment and scientific analysis of hyperthermia. The guideline describes regional deep hyperthermia (RHT) and ...

The cytotoxic enhancement of cisplatin by magnetic fluid hyperthermia (MFH) was investigated in human colon adenocarcinoma cells (Caco-2). A nanoparticle platform based on iron oxide functionalized with carboxymethyl dextran was employed to produce heat at the nanoscale. To assess the synergistic effect of hyperthermia and the anticancer drug ...

This retrospective bibliography contains citations concerning the effects of hyperthermia alone and in combination with radiation. Cited are the effects of pH on hyperthermia and radiation, the synergistic effect of hyperthermia and radiation, and the effect of sequence on host response. Dose response ...

The effects of combined irradiation and hyperthermia and of irradiation alone on normal lung tissue was investigated in rabbits. The animals of both therapy groups were irradiated with 2 Gy five times a week for a 6-week period. The animals of group 1 wer...

... Abstract : This research supports the development of a technique for breast cancer treatment using ultrasound hyperthermia (heat treatments ...

... Rolf Issels had successfully treated patients with malignant sarcomas with regional hyperthermia in combination with chemotherapy. From ... ...

We formulated a novel preparation of microspheres incorporating dextran magnetite complex (DM-MS), which enable magnetic field-induced heating for the induction of hyperthermia. Using a 500 kHz magnetic field combined with arteriolar embolization of DM-MS, inductive hyperthermia was performed for the treatment of liver tumors in rats. ...

Incubation of Chinese hamster cells at an elevated but sublethal temperature between fractions of radiation and/or pulses of hyperthermia at 45/sup 0/C strongly modified the effectiveness of cell killing. Increasing the incubation temperature from 37 to 40/sup 0/C between fractions of hyperthermia at 45/sup 0/C followed by radiation substantially enhanced ...

Using human renal carcinoma heterotransplanted in nude mice, the effects of the combined use of hyperthermia and interferon (natural human interferon-alpha; IFN-alpha, and recombinant interferon-gamma; IFN-gamma) were examined. The hyperthermic device used was the Clini-Therm, Mark VII, 915 MHz, microwave. The administration of interferon was started ...

... decrease hours or days after hyperthermia due to cell death, i.e. apoptosis, or metabolic injury. However, this most likely is not the case in the present study since the tumors were irradiated immediately...

Hyperthermia (temperatures of 39 exp 0 C or higher) enhances the killing of mammalian cells by ionizing radiation (fission-spectrum neutrons and x-rays). The nature and the magnitude of the enhanced radiation killing varies with temperature and for a fixe...

The combined effects of hyperthermia and 5-thio-D-glucose on cell survival was studied in vitro. 5-thio-D-glucose was selectively cytotoxic to hypoxic mastocytoma P815-X2 cells of DBA/2J mice and Chinese hamster V79-171b cells and the selective cytotoxicity was potentiated by mild hyperthermia at 40 to 42/sup 0/C. We conclude therefore ...

Clinical studies are being carried out to evaluate whether radiation combined with hyperthermia evokes better tumor control than that achieved with radiation alone. Thus far, 54 patients with various superficial cancers have been treated with combination hyperthermia and radiation. The heating methods used have ...

Hyperthermia in combination with chemotherapy has been widely used in cancer treatment. Our previous study has shown that rapid rate hyperthermia in combination with chemotherapy can synergistically kill cancer cells whereas a sub-additive effect was found when a slow rate hyperthermia was ...

Mouse kidneys were made hyperthermic (42.5 degrees C for 30 min) one hour before, during, or one hour after local irradiation to determine the effect of hyperthermia on radiation damage. An ultrasound beam was used to induce hyperthermia. The urinary concentrations of total protein and albumin were used as criteria of kidney injury. ...

Mouse kidneys were made hyperthermic (42.5/sup 0/C for 30 min) one hour before, during, or one hour after local irradiation to determine the effect of hyperthermia on radiation damage. An ultrasound beam was used to induce hyperthermia. The urinary concentrations of total protein and albumin were used as criteria of kidney injury. ...

Areas of skin approximately 1.5 cm in diameter on the legs of mice were made hyperthermic (30 min at 42.7/sup 0/C) by exposure to an ultrasound beam (780 kHz), a single dose of x irradiation (2000 rad), or a combination of these treatments. After 35 days, when the acute reaction had reached a steady state, the same tissue was given a second treatment by either ...

Temperature variations after traumatic brain injury are common and devastating. This has been shown most clearly with hypothermia, but the complications associated with hyperthermia in the setting of traumatic brain injury can be just as problematic. We present the case of a soldier with traumatic brain injury exposed to environmental temperatures of 115�120�F with a core ...

Survival and proliferation kinetics of chinese hamster cells after Co- gamma -, pi exp - -meson irradiation, hyperthermia (40 - 43 exp 0 C), and a combination of Co- gamma irradiation and hyperthermia were studied in this paper. After gamma -irradiation, ...

A simple technique using interstitial hyperthermia in combination with interstitial Iridium 192 implantation is described in detail. This technique was initially tested on swine and later successfully tested on seven patients. The preliminary results of the City of Hope Interstitial Hyperthermia Pilot protocol are stated. The authors ...

Hyperthermia induced from microwave 30 watts for 5 minutes or from ultrasound 1 watt/cm/sup 2/ for 5 minutes as well as x-rays were destructive to the testes of rats. The combination of x-ray and hyperthermia enhanced the destructive effect regarding the degree of reduction of spermatogenesis as well as the number of tubules affected.

Attempts to treat malignancies by elevating body temperature a few degrees above norm go back many years historically. However, hyperthermia revives recently on the basis of modern biological studies in vitro and in vivo during the last two decades. Promising results have been obtained in several pilot clinical studies using heat alone or combined with ...

Hyperthermia was used with Cf-NT to treat bulky surface neoplasms and appeared to aid the clearance and local control of selected neoplasms. Hyperthermia given in close temporal sequence with Cf-252 plaque therapy aided the clearance and local control of a radiation-induced osteogenic sarcoma. Hyperthermia given in conjunction with ...

This bibliography contains citations concerning the effects of hyperthermia alone and in combination with radiation. The effects of pH on hyperthermia and radiation, the synergistic effect on hyperthermia and radiation, and the effect of sequence on host response are considered. Dose response relationships, ...

Hyperthermia combined with /sup 60/Co gamma irradiation was studied using V79 hamster cells cultured in vitro. Modest hyperthermia (41/sup 0/C for 6 hr) enhanced the cell killing produced by acute exposure to radiation. The same treatment enhanced the effect of low dose-rate irradiation (200 rads/hr) even more. The sequence in which ...

Localized radiofrequency (RF) hyperthermia is being investigated for potential use in cancer therapy, both as a single agent and in combination with radiation therapy and chemotherapy. Standard capacitive and inductive heating techniques and new technology, including magnetrode magnetic-loop induction, are being compared for safety and efficacy. Clinical ...

Interstitial thermoradiotherapy, an experimental cancer treatment that combines interstitial radiation implants (brachytherapy) and interstitial hyperthermia, is in the early stages of investigation. In accordance with the procedure used in a current national trial protocol, a 60-minute hyperthermia treatment is administered after ...

To explore combined antiglioma effect of nitric oxide (NO) and hyperthermia, the rat C6 and human U251 glioma cells were exposed to NO-releasing agents sodium nitroprusside(SNP), S-nitrosoglutathione or PAPA-NONOate, followed by hyperthermia (1 h, 43 degrees C). While each treatment alone showed only moderate efficiency, a synergistic ...

Our early observations have confirmed that laser hyperthermia or PDT alone does not promote the tumor metastasis. In order to evaluate the combined effect of local tumor laser hyperthermia on the distant metastasis, transplantable forestomach carcinoma (Fc) in 615 line mice was treated by Nd:YAG laser hyperthermia ...

... and Toxicity of High Dose Rate Brachytherapy Combined with Hyperthermia to Treat Prostate Cancer Recurrences after External Beam Irradiation ...

Your browser does not support JavaScript! ... Abstract : Environmental heat stress can challenge the ... and combined (Tsk + Tc) effects of hyperthermia ...

Cryosurgical system utilizing liquid nitrogen and argon gas as cryogens has been used for the treatment of malignant tumors. Those devices fail to cool the tissues to the low temperatures that completely destroy the bulky tumors. It is of course difficult for the low power cooling devices using Peltier effect, to destroy the large tumors. Therefore adjunctive treatment such as ...

Effects of hyperthermia (42.5/sup 0/C) and ..gamma.. radiation (30 Gy) on ADP-ribosyl transferase, NAD/sup +/, and ATP pools in human mononuclear leukocytes have been investigated. It was found that the ..gamma..-ray activation level of the enzyme was not influenced by this hyperthermia for 45 min. Following deprivation of ATP synthesis by ...

There is increasing evidence that the use of hyperthermia alone or in conjunction with other modalities may improve the therapeutic effectiveness of treatment of cancer. The present clinical studies were carried out to evaluate the response of normal and tumor tissues in patients with various cutaneous malignant lesions to repeated courses of hyperthermia ...

There is increasing evidence that the use of hyperthermia alone or in conjunction with other modalities may improve the therapeutic effectiveness of treatment of cancer. The present clinical studies were carried out to evaluate the response of normal and tumor tissues in patients with various cutaneous malignant lesions to repeated courses of hyperthermia ...

The regrowth delay of a transplanted syngeneic mouse mammary carcinoma designated MT2 was used to estimate the effects of three-fold combination treatments: X-irradiation; hyperthermia and radiosensitizer; and misonidazole (Ro-07-0582). The experiment entailed five groups of experimental mice: untreated control; X-rays alone; X-rays plus ...

Approximately 25% of patients with colorectal cancer develop metastases to the liver, and surgery is currently the best treatment available. But there are several patients who are unresectable, and isolated hepatic perfusion (IHP) offers a different approach in helping to treat these patients. IHP is a method used for isolating the liver and delivering high doses of chemotherapeutic agents. The ...

Host resistance to tumor growth was studied in athymic nude mice of C57BL background. Animals were pretreated in the left hind leg by local hyperthermia, local x irradiation, or combined local hyperthermia and x irradiation. Twenty-four h posttreatment, the animals were inoculated with the metastatic Lewis lung carcinoma tumor. Half of ...

Mouse legs were irradiated to a dose of 30 Gy. After 50 days, when the acute reaction had regressed to a steady state, they were retreated with either various doses of x rays (15 to 30 Gy), hyperthermia, 45 min at 42.7 degrees C, cis-DDP, or a combination of these agents. The maximum skin reactions and the skin reactions integrated over 50 days were ...

The benefit of combining hyperthermia and chemotherapy to treat cancer is well established. However, combined therapy has not yet achieved standard of care status. The reasons are numerous and varied, however the lack of significantly greater tumor cell sensitivity to heat (as compared to normal cells) and the inability to deliver heat ...

Unilateral ocular squamous cell carcinoma in a horse was treated effectively with a combination of repeated radiofrequency hyperthermia and interstitial radiotherapy. These 2 modalities of treatment are synergistic. Interstitial irradiation was achieved, using {sup 198}Au implants to deliver a total dose of approximately 5,000 rads/implant over an area of ...

Pregnant Wistar rats were exposed to either microwave-induced hyperthermia or gamma radiation or a combination of both. In microwave-induced hyperthermia, a core temperature of 42 degrees C was slightly teratogenic and a core temperature greater than or equal to 43 degrees C was highly teratogenic. Gamma radiation at 40 cGy was ...

The use of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") as a recreational drug has spread worldwide. Fatal hyperthermia is a likely side effect of using MDMA in combination with monoamine oxidase inhibitors. However, most antidepressants do not pose a high risk of developing hyperthermia when used in conjunction with MDMA. ...

The effect of hyperthermia alone or combined with X irradiation on the proliferative capacity of CHO cells was studied for temperatures between 41 and 46/sup 0/C. For heat treatments in the range 41-43/sup 0/C or 43-46/sup 0/C, the Arrhenius plot yielded an inactivation energy of 417 +/- 28 and 167 +/- 16 kcal/mole, respectively. ...

At the Claire Zellerbach Saroni Tumor Institute, Mount Zion Hospital and Medical Center, 38 patients who failed definitive radiotherapy and chemotherapy were treated with 915 megahertz and 2450 megahertz microwave hyperthermia to observe normal tissue tolerance and therapeutic responses. When hyperthermia was combined with radiation, ...

BackgroundThe best method to deliver intraperitoneal chemotherapy (IPC) for peritoneal carcinomatosis from ovarian cancer is not well defined. The aim of this study was to assess the ability of hyperthermia and adrenaline to enhance the intratumoral accumulation of cisplatin in a rat model of peritoneal carcinomatosis.MethodsFour groups of 5 BDIX rats with ovarian peritoneal ...

There is a clear rationale for using hyperthermia in cancer treatment. Treatment at temperatures between 40 and 44 degrees C is cytotoxic for cells in an environment with a low pO(2) and low pH, conditions that are found specifically within tumour tissue, due to insufficient blood perfusion. Under such conditions radiotherapy is less effective, and systemically applied ...

The effect of the treatment of the cultured mammalian cells with a relatively new anti-cancer drug teniposide (VM26), radiation (4 Gy), hyperthermia (42 deg. C and 45 deg. C) and caffeine, in various combinations, has been studied. The following conclusio...

Sixteen patients were treated for liver cancer (primary and metastatic) by a combination of internal radiation therapy with intra-arterial yttrium 90 microspheres and regional hyperthermia with electromagnetic radiation. Four patients have their liver disease apparently controlled; two had a partial regression of more than 50%; and two had a partial ...

The results from experimental studies indicate that hyperthermia is both an effective complementary treatment to, and a strong sensitiser of, radiotherapy and many cytotoxic drugs. Since the first international hyperthermia conference in 1975, Washington DC, techniques to increase tumour temperature have been developed and tested clinically. ...

Low hyperthermia at 40/sup 0/C either before or after X irradiation did not alter the slope of the radiation dose-cell survival curve but reduced the D/sub q/ from 145 to 41 or to 0 rad for a pre- or postirradiation incubation period of 2 hr at 40/sup 0/C, respectively. In contrast, hyperthermia at 45/sup 0/C increased the slope of the radiation survival ...

Previous attempts to review the literature on magnetic nanomaterials for hyperthermia-based therapy focused primarily on magnetic fluid hyperthermia (MFH) using mono metallic/metal oxide nanoparticles. The term "hyperthermia" in the literature was also confined only to include use of heat for therapeutic applications. Recently, there ...

The combined effect of hyperthermia and doxorubicin on the neurogenic rat cell line BT/sub 4/C was found to be synergistic in vitro. The present investigation was initiated to study if this synergistic effect also could be obtained in vivo. An enhanced effect occurred when doxorubicin and 4'-epi-doxorubicin 7 mg/kg body weight were given 30 ...

Mitotically synchronized cultures of HeLa S-3 cells were subjected to the treatment of radiation (400 rad), hyperthermia (43/sup 0/C), and a combination of both at different phases of the division cycle. The radioresistance was most pronounced in the mid G-1 and late S phases, while thermal resistance was greatest in the early G-1 phase and steadily ...

A case of combined abdominal wall paresis and incisional hernia after laparoscopic cholecystectomy is reported. The paresis possibly occurred by a lesion of the N. intercostalis when extending the incision for stone extraction. Possibly the paresis was a predisposing factor for the development of an incisional hernia. The causes of ...

Multidrug resistance (MDR) plays a major obstacle to successful gastric cancer chemotherapy. The purpose of this study was to investigate the MDR reversal effect and mechanisms of hyperthermia in combination with neferine (Nef) in adriamycin (ADM) resistant human SGC7901/ADM gastric cancer cells. The MDR cells were heated at 42�C and 45�C for 30 min ...

For superficial hyperthermia a custom-built multi-applicator multi-amplifier superficial hyperthermia system operating at 433 MHz is utilised. Up to 6 Lucite Cone applicators can be used simultaneously to treat an area of 600 cm2. Temperatures are measured continuously with fibre optic multi-sensor probes. For patients with non-standard clinical problems, ...

The modifying effects of m-aminobenzamide (m-ABA), an inhibitor of poly(ADP-ribose) synthesis, on 42/sup 0/C hyperthermia- and/or radiation-induced cell killing were examined in Chinese hamster V-79 cells. When cells were exposed to 42/sup 0/C hyperthermia in combination with m-ABA (10 mM), cell survival decreased compared with that ...

Here we review the significance of changes in vascular thermotolerance on tumor physiology and the effects of multiple mild temperature hyperthermia (MTH) treatments on tumor oxygenation and corresponding radiation response. New information suggests that although hyperthermia is a powerful modifier of tumor blood flow and oxygenation, sequencing and ...

Interstitial hyperthermia of brain tumors has been made by an implanted heating system using a metal implant with low Curie temperature, which was stereotactically implanted in a tumor. Induction heating of the implant was obtained by eddy current in a magnetic field. Safe, repeated and long-term treatment of 25 cases of brain tumor has been made with this system. Among 22 ...

After a short introduction the first part of the editorial describes biological and technical fundamentals of clinical hyperthermia. Results obtained in the field of thermobiology lead to conclusions for the clinical application of hyperthermia in combination with radiation therapy. These are concerned with the direct cytotoxic effect ...

Hyperthermia (HT) has a proven benefit for treating superficial malignancies, particularly chest wall recurrences of breast cancer. There has been less research utilising HT in patients with locally advanced breast cancer (LABC), but available data are promising. HT has been combined with chemotherapy and/or radiotherapy in the neoadjuvant, definitive and ...

Surgery, radiation and chemotherapy are currently the most commonly used cancer therapies. Hyperthermia has been shown to work effectively with radiation and chemotherapy cancer treatments. The major obstacle faced by previous hyperthermia techniques has been the inability to deliver heat to the tumor in a precise manner. The ability to deliver cytotoxic ...

... that the Malignant Hyperthermia Mattress, prototype II ... Descriptors : *HYPERTHERMIA, *MATTRESSES, TEST AND EVALUATION, SIMULATION ...

The recovery kinetics from the damage resulting from combination treatments of X-irradiation and 42 degrees and 44 degrees C hyperthermia were analyzed in Chinese hamster V79 cells. The survival of cells attained to the additive level, when either 42 degrees C hyperthermia or 42 degrees C hyperthermia and ...

Since 1976, two groups of patients have been treated with local microwave hyperthermia immediately following ionizing radiation. Group A patients had measurable multiple lesions assigned radiotherapy only, microwave hyperthermia only, or combined treatment. Ionizing radiation in 200 to 600 rad fractions was used 2 to 5 times per week ...

Many malignant cell lines exhibit a therapeutic response to supernormal temperatures. Selective destruction of tumor cells has been observed following moderate hyperthermia (42/sup 0/ to 43/sup 0/C) in vivo, and tumor eradication by heat has been achieved without normal tissue morbidity. Thermal cell killing appears to be independent of oxygen tension, and the sensitivity of ...

Many malignant cell lines exhibit a therapeutic response to supernormal temperatures. Selective destruction of tumor cells has been observed following moderate hyperthermia (42� to 43� C) in vivo, and tumor eradication by heat has been achieved without normal tissue morbidity. Thermal cell killing appears to be independent of oxygen tension, and the sensitivity of S-phase ...

The effect of delay between hyperthermia (41/sup 0/C for 1 hr) and irradiation was studied in plateau phase V-79 Chinese hamster cells. For irradiation preceding hyperthermia, a delay of 2 hr resulted in a complete loss of potentiation. In contrast, no significant loss of potentiation was seen for delay times of 1 to 2 hr for ...

Women should be encouraged to become fit before they become pregnant. During pregnancy, those who were accustomed to aerobic exercise before pregnancy can probably continue their sports involvement throughout pregnancy, at the same perceived level of exertion. Weight training and calisthenics are advisable during pregnancy, even for those who never practised them before. Pregnant women should ...

Researchers studied glucose turnover in male inbred mice during and after whole-body hyperthermia for 1 hour at 40 degrees or 41 degrees C by giving them injections of (/sup 14/C)glucose with and without a glucose load and measuring the expired /sup 14/Co/sub 2/. Expiration of /sup 14/CO/sub 2/ was increased during hyperthermia but decreased considerably ...

Hypoxia has been demonstrated to play an important role in the effect of hyperthermia on tumors. The influence of different factors modifying the oxygenation status of a transplantable murine mammary adenocarcinoma has been studied. The effect of hyperthermia alone on the tumor is not significantly influenced by the change in oxygenation status during the ...

Hyperthermia (temperatures of 39/sup 0/C or higher) enhances the killing of mammalian cells by ionizing radiation (fission-spectrum neutrons and x-rays). The nature and the magnitude of the enhanced radiation killing varies with temperature and for a fixed temperature during irradiation, the enhanced lethality varies inversely with dose rate. For temperatures up to 41/sup 0/C, ...

A mouse adenocarcinoma was treated with 20 Gy X rays, hyperthermia (30 minutes at 43 degrees C), Ro-03-8799, or a combination of two or three of these agents. Combined treatments increase growth delay in the tumor and this was greatest with the combination of all three modalities. Extensive amounts of necrosis were ...

Despite convincing evidence for hyperthermic radiosensitization, the invasive means of achieving and monitoring hyperthermia and the lack of good thermal dosimetry have hindered its use in routine clinical practice. A non-invasive method to generate and monitor hyperthermia would provide renewed enthusiasm for such treatments. Near-infrared absorbing gold ...

Clinical trials of hyperthermia in combination with radiation therapy or chemotherapy undertaken over the past decades in Japan have been reviewed. Originally developed heating devices were mostly used for these trials, which include RF (radiofrequency) capacitive heating devices, a microwave heating device with a lens applicator, an RF intracavitary ...

Similar malformations of the central nervous system including encephaloceles and exencephaly are induced by treatment of pregnant hamsters with sodium arsenate or hyperthermia on the eight day of gestation. These two treatments are synergistic in that combinations of minimal teratogenic levels of each cause a marked increase in fetal resorptions and the ...

This predoctoral grant was written to examine the effect of combining fever-range whole body hyperthermia with cytokine immunotherapy and chemotherapy in animal models of breast cancer. Progress in year number two has recently improved with the implementa...

Increased radiation lethality was observed in HeLa cells when irradiation was followed by two hours of incubation at 41/sup o/C in the presence of 1 mM procaine hydrochloride. The increase of radiation lethality produced by this combination was significantly higher than that produced by hyperthermia alone. Two hours of incubation with procaine at 37/sup ...

Combined treatment of PDT and hyperthermia was examined on Ehrlich ascites tumor cell viability and A22 hepatoma tumor growth inhibition. Histological evaluations of tumors after different treatments have shown tumor necrosis, congestion of blood vessels and hemorrhage. The most drastic damages were observed after simultaneous PDT and ...

Covalent DNA-protein crosslinks occur in exponentially growing mouse leukemia cells (L1210) after exposure to ionizing radiation. The amount of DNA-protein crosslinks as measured by a filter binding assay is dose dependent upon X irradiation. Although hyperthermia and radiation in combination are synergistic with respect to cell lethality, the ...

From July 1986 to July 1989, 40 patients (92% pretreated) with deep-seated, advanced soft tissue sarcomas (STS, 25 patients), Ewing's sarcomas (ES, eight patients), osteosarcomas (OS, three patients) and chondrosarcomas (ChS, four patients) were treated at the University of Munich in a protocol involving regional hyperthermia (RHT) combined with ifosfamide ...

Traumatic hernia of the abdominal wall is a rare and easily missed injury in the presence of major pelvic and abdominal lesions. We present a radiographically documented case of combined pelvic and acetabular fracture with a major contralateral traumatic hernia with avulsion of the internal oblique, the external oblique and the ...

abdominal wall.3,6,7 In the study reported in Ref. 6, pork fat and a combination of pork fat and muscle were of the muscle and fat layers of the abdominal wall on ultrasonic pulses. The purpose of this study. FIG. 2. Individual layers of abdominal wall specimen 113. a Views show- ing skin in the fat section

Survivin is a member of the inhibitor of apoptosis (IAP) family and plays an important role in inhibiting apoptosis and boosting angiogenesis, so targeting therapy of survivin is a promising strategy for advanced cancers. Similarly, hyperthermia is also a good approach to treat tumors in clinical. However, the improvement of antitumor efficacy is extremely limited for any ...

Therapeutic hyperthermia is a procedure that involves heating tissues to a higher temperature level, typically ranging from 41 degrees C to 45 degrees C. Its combination with radiotherapy and/or chemotherapy has been performed for many years, with remarkable success in treating advanced and recurrent cancers. The current hyperthermia ...

Ultrasonically induced hyperthermia (4.75 MHz) and proton irradiation (160 meV) were evaluated alone and combined to treat experimental choroidal melanoma in 58 rabbit eyes. Threshold tumoricidal doses were established for each modality. Therapy was performed combining subthreshold doses of heat and radiation. Focused ultrasonic energy ...

The purpose of this study was to evaluate the effect of hyperthermia on the histologic and functional response of the canine kidney, a late-responding normal tissue, to irradiation. Both kidneys were irradiated. Radiation was delivered in single doses of 0, 10, or 15 Gy. Whole-body hyperthermia was used to produce renal kidney temperatures approximating ...

External microwave (EMW) hyperthermia system (2.45 GHz wave frequency) was evaluated by in vitro studies and in vivo pleural metastasis animal model. Three different non-small-cell lung cancer cells and normal fibroblast cells (control) were treated once a day for 3 days with the prototype EMW system applying mild (39 degrees C), moderate (43 degrees C), and severe (47 degrees ...

Patients with superficial malignant lesions have been treated with local hyperthermia in association with radiation. Heat was applied by means of a newly assembled apparatus with a variable frequency microwave generator (200 to 3000 MHz). The apparatus was operated at a frequency of 500 MHz; heat was delivered with non-contact applicators designed for different surface ...

Abdominal pain combined with fever and elevated white blood count as well as c-reactive protein are the main features of any intra-abdominal inflammation or perforation. Since these pathologies are commonly encountered, it is of crucial importance for the primary care doctor as well as the specialist to have basic knowledge about ...

A total of 8 infants presenting with sepsis-like illness were diagnosed to have human parechovirus (HPeV) infection; of which, 5 had abdominal distension and 6 had an erythematous rash. A combination of abdominal distension and erythematous rash was observed in 4 infants. The abdominal symptoms can be very ...

This study was purposed to explore the effect of hyperthermia on sensitivity of multiple myeloma cells RPMI 8226 to adriamycin (ADM) and its mechanism. The working concentration of ADM against RPMI 8226 cells was defined by MTT assay. RPMI 8226 cells were divided into 4 groups: control group, hyperthermia (42�C) group, chemotherapy (ADM) group and ...

Covalent DNA-protein crosslinks occur in exponentially growing mouse leukemia cells (L1210) after exposure to ionizing radiation. The amount of DNA-protein crosslinks as measured by a filter binding assay is dose dependent upon x irradiation. Although hyperthermia and radiation in combination are synergistic with respect to cell lethality, the ...

The principal objective of this research is the development of the combination of hyperthermia (HT) and high dose rate (HDR) brachytherapy as a therapy for locally advanced, recurrent prostate cancer after failure using front line external beam definitive...

The objectives of this study were to quantitate the effects of local tumor hyperthermia (LTH) and concomitant x irradiation (RAD) on a moderately radioresistant murine fibrosarcoma in situ. Comparisons were made to the combined treatment response on the Ridgway osteogenic sarcoma, a radiosensitive tumor previously used in this laboratory and to establish ...

Primary malignant melanoma of the esophagus (PMME) forms about 0.1% of all primary esophageal cancers. Treatment options are very limited for patients unfit for surgery. This is the first report describing the results of external radiotherapy combined with regional hyperthermia for two inoperable PMME patients. Two patients with a T2-3N0M0 PMME were ...

The present report deals with the results on phenothiazine derivatives such as promethazine (PMZ), trimeprazine (TMZ), trifluoperazine (TFP) and prochlorperazine (PCP) and their comparison with that of chlorpromazine (CPZ). Their efficiency in combination...

... Pei, and L. Xiu-Qin. Neurobehavioral study of prenatal exposure to hyperthermia combined with irradiation in mice. Neurotoxicol. ... figure �FIG. 1. The teratogenic effect of a prenatal 4-Gy radiation exp...

Hyperthermia has long been used in combination with radiation for the treatment of superficial malignancies, in part due to its radiosensitising capabilities. Patients who suffer superficial recurrences of breast cancer, be it in their chest wall following mastectomy, or in their breast after breast conservation, typically have poor clinical outcomes. They ...

... incubating the cells with 5 or 10 mM caffeine. In the case of hyperthermia alone or in combination with radiation, however, caffeine was somewhat less effective. This does not mean, ... ...

Experiments on responses of tumors, implanted subcutaneously in the leg, to irradiation alone or combined with heat are reported. The influence of factors modifying the fraction of hypoxic cells (e.g. anesthesia of the animal and tumor volume) is also dis...

A microwave heating apparatus with a frequency of 2,450 MHz and an inductive radio-frequency heating apparatus were developed for hyperthermia for cancer therapy, and clinical trials of combined radiation and hyperthermia were conducted. During the same period, a capacitive type radiofrequency unit was used. The tumors included ...

Acute and chronic histopathologic and biochemical effects on normal canine liver tissue from a single intraoperative application of heat and radiation, heat alone, and radiation alone have been evaluated in 54 adult mongrel dogs. The tolerance of normal canine liver tissue to single doses of intraoperative radiation therapy (IORT) was evaluated at doses of 5, 10, 20, 30, and 40 Gy. In addition, ...

The proliferation of human melanoma cells in vitro during the first 3 days after irradiation and/or hyperthermia was followed by two-parameter flow cytometry combining cell cycle analysis on the basis of DNA content with Ki-67 antibody labeling. It was found that cells arrested or delayed in the S and G{sub 2} phases of the cell cycle were Ki-67-positive ...

We report a case of an overdose with fetal demise from the intravaginal administration of misoprostol. A 25-yr-old gravid female self-administered 6000 micrograms misoprostol intravaginally and 600 micrograms orally. She rapidly developed shaking chills, abdominal and extremity cramping, emesis, and confusion. Hyperthermia and hypotension developed within ...