...Efficiency, Office of Technology Development, Energy Efficiency and Renewable Energy. Decision and Order In the Matter of: Miele, Inc. (Case No. CD-005) Background Title III, Part B of the Energy Policy and Conservation Act of...
...on December 20, 2011. Kathleen B. Hogan, Deputy Assistant Secretary for Energy Efficiency, Energy Efficiency and Renewable Energy. Decision and Order In the Matter of: Miele, Inc. (Case No. DW-006). I. Background and Authority...
Part of the series "Coleccion Mini-Libros" (Mini-Book Collection), the booklet is a factual account of the life of a bee. Designed to provide a tool for education of the Spanish-speaking child, as well as to stimulate an interest in Spanish among the youth of our country, the publication is a compilation of photographs with a description of bees…
ml of acetone at each time. Concentrated extracts are transferred into a chromatographic column which, then 5 ml of acetone acidified by 1,5 ml of HCI 2 N, and further with 60 ml of acetone. The last elution is collec- ted, concentrated and dissolved in 0,5 ml of acetone. The chromatography is achieved on a thin
This chapter provides a comprehensive characterization of the bees of the Neotropics, the region from southern Mexico to the southern tip of South America. The bees of this region are very diverse. There are over 3680 species known with many additional species yet to be discovered. The biology, es...
Mariana Muñoz-Romo; Maricela Sosa; Yveth Casart Quintero
Digestibility of columnar cacti pollen grains in the glosophagine bats Glossophaga longirostris and Leptonycteris curasoae (Chiroptera: Phyllostomidae). We examined the protoplasmic assimilation of columnar cacti pollen grains in two species of Venezuelan desert glosophagine bats, Glossophaga longirostris and Leptonycteris curasoae, by determining the amount of empty (digested) pollen grains found in their fecal samples. To determine the amount of empty
...Inc. From the Department of Energy Residential Dishwasher Test...Interim Waiver AGENCY: Office of Energy Efficiency and Renewable Energy, Department of Energy. ACTION...Title III, Part B of the Energy Policy and Conservation Act of...
incidencia (es- tructural y funcional) que representa la introducción masiva de la abeja doméstica (Apis aquellas plantas que presentaban una menor (o nula) incidencia de A. mellifera (plan- tas alejadas > 1 km
: Deutsch-polnische Begegnung in Polen Â RzeszÃ³w (1), Schottland- Trees for life (2), Alle Wege fÃ¼hren nach Projekts Produkt Ort Zeit 1 Deutsch-polnische Begegnung in Polen Â RzeszÃ³w PrÃ¤sentationswand unter Wich 3 II 11:45- 12:45 Feld I ab 11.15 Uhr 10 Parkour Vorstellung / Video Feld II ab 11.15 Uhr 11 Einblicke
Millar, Andrew J.
specicity for lung pathology, while pulmonary biopsy is invasive and xed tissue cannot inform on the dynamic of active fibrogenesis in human lung tissue Citation for published version: Aslam, T, Miele, A, Chankeshwara in human lung tissue' Chemical Science., 10.1039/c5sc01258a Digital Object Identifier (DOI): 10.1039/c5sc
...an energy test, the water usage would be overstated. In this case, the water energy usage would be...true energy consumption characteristics as to provide materially...Whirlpool Corporation. 5. Manufacturers of Similar...dishwashers with an integrated water softener, Miele...
Benton, Jean E., Ed.; Swami, Piyush, Ed.
The 10th Triennial World Conference of the World Council for Curriculum and Instruction (WCCI) was held September 10-15, 2001 in Madrid, Spain. The theme of the conference was "Cultures of Peace." Thirty-four papers and presentations are divided into nine sections. Part I, Tributes to the Founders of WCCI, includes: (1) Tribute to Alice Miel…
Amy J. C. Cuddy; Susan T. Fiske
In first encounters, age is one of the earliest characteristics we notice about other people (Fiske 1998; Kite, Deaux, and Miele 1991). Conscious or not, noticing age drives our interactions with others. Age seems to an- swer: How should I address them? What are their political views? What do they know about popular culture? Will they be competent? Socially aware?
Cohen, Monroe D., Ed.
The 20 articles presented are under three classifications: general philosophy, methodology, and case studies. The articles are: The World House: Building a Qualitative Environment for All the World's Children by Alice Miel; Accepting the Selves of Others: People Around the World by Leonard S. Kenworthy; Universality of Differences by Margaret L.…
Campanario, Juan Miguel
Bronchalo, Mi&el Angel Hidalgo Grupo de Ciencia Cognitiva, Departamento de FÃsica, Universidad de AlcalÃ¡ be obtained from the exact normalized solution for the electron SchrÃ¶dinger equation of the sys- tem by p
Examined here is the way in which the indigenous uprising in Chiapas has been able to mobilize international support by employing globally shared discourses to articulate collective identities and political demands. The focus is on the group of liberation theology Roman Catholics in San Pedro Chenalhó and their political association Las Abejas, today one of the most potent symbols of
María del Pilar Blanco-Parra; Ivonne Bejarano-Rodríguez
Diet and reproduction of the main fish species from the Mesay river (Colombian Amazon region) during the flooding season. The diet and reproduction of fish communities in three biotopes (river, stream, and lake) of the Mesay floodplain-river complex (Puerto Abeja, Serranía de Chiribiquete National Natural Park, Caquetá, Colombia) were sampled during the \\
ALTERACIÓN DE MUTUALISMOS PLANTA-ANIMAL DEBIDO A LA INTRODUCCIÓN DE ESPECIES EXÓTICAS EN- ción de endémicas. En este trabajo se analiza la disrupción de mutualismos insulares entre plantas y fracción de las plantas insulares nativas sufre limitaciones en el cuajado de semillas por falta de polen y
- tro objetivo es investigar si las plantas invasoras afectan a la di- versidad genética de este grupo de plantas amenazadas de Galá- pagos, que se han denominado dragoncillos de Galápagos y que se reúnen la trasferencia de polen pudiera es- tar alterada por la presencia de plantas introducidas y, por tan
febrero, a las Islas Galápagos para estudiar el impacto de las especies invasoras en las plantas de semillas la introducción de plantas entomófilas, que dispersan su polen mediante insectos cantidad de plantas en flor, por lo que es posible que se registren importantes cambios en las
dann an die zuständigen Beraterinnen und Berater weitervermittelt. Telefonisch gibt die Info-Line (+49 · Allgemeine Kooperationsverträge: FINNLAND University of Jyväskylä 4 FRANKREICH Université Catholique de l'Ouest, Angers 5 Université d'Angers 6 GROßBRITANNIEN University of Hull 7 Keele University 8 POLEN University
Alejandro A. Castro-Luna; Vinicio J. Sosa
We report the dispersal of Conostegia xalapensis (Melastomataceae) and Coussapoa oligocephala (Urticaceae) seeds by Underwood's long-tongued bat, a species considered to be a specialized nectar and pollen consumer.Informamos la dispersión de semillas de Conostegia xalapensis (Melastomataceae) y Coussapoa oligocephala (Urticaceae) por el murciélago de lengua larga de Underwood, una especie considerada como consumidora especializada en néctar y polen.
.30 Uhr: Burhan Öçal's Musica Kerwansaray Das neue Projekt des legendären Istanbuler Perkussionisten http://www.youtube.com/user/burhanoecal?feature=watch Sa, 19.07. 16.30 Uhr: Megitza Feurige Ethno Rock Jazz Fusion aus Polen http://www.youtube.com/user/Megitza/videos 18.30 Uhr: Sierra Leone's Refugee All Stars Afro-Latin, Highlife, Roots & Reggae http://www.youtube.com
Sven Bernhard Gareis
\\u000a Das von Dänemark, Deutschland und Polen getragene Multinationale Korps Nordost (Multinational Corps Northeast, MNC NE) wurde am 18. September 1999 im nordwestpolnischen Stettin aufgestellt. Auf den ersten Blick fügte sich seine Gründung\\u000a logisch in die lange Reihe der in den 1990er Jahren neugeschaffenen multinationalen Truppenkörper ein. Jedoch war dieses Korps\\u000a von Beginn an hinsichtlich seiner Entstehung, seiner Zusammensetzung, seiner Aufgaben
Alvarez, Santiago; Jessick, Ashley M; Palacio, Jaime A; Kolok, Alan S
The objective of this study was to determine whether fish collected from the La Miel or Nechí Rivers (Colombia) differed in muscle methyl mercury (meHg) concentration. Two fish from six different species were collected from markets adjacent to each river. Overall, fish collected from the market adjacent to the Nechí River contained higher levels of meHg. This result however is being driven by very high meHg concentrations in four individual fish, three of which are Pimelodid, long-whiskered catfish. These catfish may represent ideal sentinel organism for the detection of meHg contamination in Colombian rivers. PMID:22065125
Gonzalez, Victor H.; Engel, Michael S.
. Falchetti, A., & G. Nates-Parra. 2002. Las hijas del sol: Las abejas sin aguijón en el mundo Uwa, Sierra Nevada del Cocuy, Colombia. In: Ulloa, A (Ed.), Rostros Culturales de la Fauna: 175?214. Instituto Colombiano de Antropología e Historia y Fundación... (CC BY-NC-ND 3.0). ISSN 2325-4467 Maria Guiomar Nates-Parra: Biographical sketch and summary of contributions to the melittological knowledge of Colombia Victor H. Gonzalez1,2 & Michael S. Engel2 Abstract. A brief account of some aspects...
Argyros, Ioannis; Hilout, Saïd
We introduce the new idea of recurrent functions to provide a new semilocal convergence analysis for Newton-type methods, under mild differentiability conditions. It turns out that our sufficient convergence conditions are weaker, and the error bounds are tighter than in earlier studies in some interesting cases (Chen, Ann Inst Stat Math 42:387-401, 1990; Chen, Numer Funct Anal Optim 10:37-48, 1989; Cianciaruso, Numer Funct Anal Optim 24:713-723, 2003; Cianciaruso, Nonlinear Funct Anal Appl 2009; Dennis 1971; Deuflhard 2004; Deuflhard, SIAM J Numer Anal 16:1-10, 1979; Gutiérrez, J Comput Appl Math 79:131-145, 1997; Hernández, J Optim Theory Appl 109:631-648, 2001; Hernández, J Comput Appl Math 115:245-254, 2000; Huang, J Comput Appl Math 47:211-217, 1993; Kantorovich 1982; Miel, Numer Math 33:391-396, 1979; Miel, Math Comput 34:185-202, 1980; Moret, Computing 33:65-73, 1984; Potra, Libertas Mathematica 5:71-84, 1985; Rheinboldt, SIAM J Numer Anal 5:42-63, 1968; Yamamoto, Numer Math 51: 545-557, 1987; Zabrejko, Numer Funct Anal Optim 9:671-684, 1987; Zinc?ko 1963). Applications and numerical examples, involving a nonlinear integral equation of Chandrasekhar-type, and a differential equation are also provided in this study.
Stewart, D.K.; Mathes, M.V.
This report contains data for 1,127 drainage-area divisions of the Monongahela River Basin, from the headwaters to the confluence of the Monongahela River and Dunkard Creek. Data, compiled in down- stream order, are listed for streams with a drainage area of approximately 2 square miels or larger, and for U.S. Geological Survey streamflow- gaging stations. The data presented are the stream name, the geographical limits, the latitude and longitude of the point, the name of the county and the 7-1/2 minute quadrangle in which the site lies, and the drainage area of that site. The total drainage area of the Monongahela River Basin, West Virginia, is 4,374.94 square miles.
Creech, Billy Gene
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Blanco-Parra, María del Pilar; Bejarano-Rodríguez, Ivonne
The diet and reproduction of fish communities in three biotopes (river, stream, and lake) of the Mesay floodplain-river complex (Puerto Abeja, Serrania de Chiribiquete National Natural Park, Caquetá, Colombia) were sampled during the "high water" level or flooding period. A total of 79 species of fishes from 15 families and four orders were collected between July and September 2000. The most important items in their diet were fruits and seeds. Approximately 46 % of captured fish were near maturity, and 35 % were mature. The feeding and reproductive behavior of these fish were consistent with other studies on migratory Amazonian species during the high water period, when the floodplain plays an important role in the availability of food and refuge. During this period the fish make use of the vast food availability to accumulate fat reserves that later produce the energy needed for gonadal maturation and breeding migrations. PMID:18491626
This paper focuses on the solution of two problems related to cycling. One is to determine the velocity as a function of distance which minimizes the cyclist's energy expenditure in covering a given distance in a set time. The other is to determine the velocity as a function of the distance which minimizes time for fixed energy expenditure. To solve these problems, an equation of motion for the cyclist riding over arbitrary terrain is written using Newton's second law. This equation is used to evaluate either energy expenditure or time, and the minimization problems are solved using an optimal control formulation in conjunction with the method of Miele [Optimization Techniques with Applications to Aerospace Systems, pp. 69-98 (1962) Academic Press, New York]. Solutions to both optimal control problems are the same. The solutions are illustrated through two examples. In one example where the relative wind velocity is zero, the optimal cruising velocity is constant regardless of terrain. In the second, where the relative wind velocity fluctuates, the optimal cruising velocity varies. PMID:8132689
During analysis of the competitor's velocity in a run, strong assumptions are imposed upon the runner's tactic. It is assumed that the competitor uses his/her maximal propulsive force in short-distance events. The runner's velocity is assumed constant in long-distance races. None of these assumptions is satisfied during middle-distance races. In this study, the competitor's velocity, minimizing the time taken to cover the distance, is determined by means of extremization of linear integrals using Green's theorem (Miele's method). The model of the competitor's motion is based on two differential equations: the first one derives from Newton's second law, the second one is the equation for power balance. The theory is illustrated with two examples referring to competitive running and swimming. The minimum-time competitive run can be broken into three phases: -the acceleration, -the cruise with the constant velocity, and -the negative kick at the end of the race. The problem has a similar solution in competitive swimming, however, the acceleration is replaced by the gliding phase. PMID:8849819
Plavsi?, Z; Petrovi?, M; Popovac, D
There are different opinions on the positive effect of hyposensitisation in the treatment of allergic respiratory diseases. In this paper we wish to point out our experience, without intention to clear up these "contrary opinions". Sixty patients of both sexes, aged from 10-55 years, were on specific hyposensitisation over a period from three to five years. Two thirds (63%) were with bronchial asthma and 37% with allergic rhinitis. Most of them (80%) were on specific hyposensitisation to one allergen (Dermatophagoides pteronyssinus, grass or reguid polen), and to two allergens 20% patients. During this therapy 63% of patients had no additional medicamentae therapy. Most of them stopped additional medication during the first year of immunotherapy. Ten percent of patients took medicaments when they needed them, and 28% took them continually. Clinical symptoms characteristic of these diseases were also rare. The average value of IgE was 636 UI/ml before and 341 UI/ml after the immunotherapy. The efficacy of immunotherapy depended on the correct selection of patients, good standardisation of antigen extract, and a right dose of allergen in the prolonged immunotherapy. PMID:17974388
Chiril?, M; Florescu, L; Popescu, M; Capetti, E; Panait, E
The study carried out on 582 asthma patients and 164 healthy controls, ranging in age from 5 to 60 years, dwelling in four different towns ( Sibiu , Media?, Baia Mare, Sighetul Marma tiei ) showed that the most frequently involved antigen in allergic bronchial asthma was house dust (50.3 to 86%), followed by Dermatophagoides pteronissinus and atmospheric fungi, and the most frequently encountered associations were likewise between these allergens, hence the orientation towards a specific hyposensitizing therapy. In these localities with a rich gramineous vegetation there was a high per cent of sensitization to the polen of these plants. Sensitization to woollen hairs has been reported in a high percent in the region of Maramure ? and is linked to its ethnical characteristics. In many cases the patients also exhibited hypersensitiveness to bacteria, associated with environmental allergens, the vicious circle realized by an allergic-infectious mechanism being known. The conclusions of the study on the etiology of bronchial asthma in these geographical areas will be used as a basis for the treatment and its orientation. PMID:6539944
Ramos Morín, C J; Canseco González, C
A retrospective review of 247 clinical files of patient that have responded to the office allergy and immunology since 1990 to 1993 in Monclova, Coah., for allergy illness. This study was to determine the frequency of Aeroalergens and foods sensitization in Monclova, Coahuila, mediated Allergy Test Skin (intradermo reactions, and Prick) and MAST immuno Systems (Multiple Allergy System Test). The patients were highly sensitive to house dust (13.5%) others aeroalergen pollen grains, were; rusian thistle (7.1%), Pigweed (5.4%), Cynodon Dactylon (4.9%), Pecan (4.8%), Ragweed Mix (4.8%), Rye grass (4.8%) other polen (32.4%). The molds: Candida (3.2%), Alternaria (2.7%), Rhizopus (3.6%), Penicillium (2.1%), Fusarium (2.1%), other molds (8.7%). The foods more important were: Wheat (21.3%), Cheese (10.0%), Shellfish Mix (10.0%), Pork (8.8%), Egg Yolk (7.5%). PMID:9377111
Harmanci, Koray; Razi, Cem H; Toyran, Muge; Kanmaz, Gozde; Cengizlier, Mehmet R
Specific immunotherapy (SIT) is one of the treatment modalities recomended for the management of asthma and allergic rhinitis by international guidelines. A potential benefit of immunotherapy (IT) is to prevent the development of sensitisation to new allergens. There is stil no conclusion on this subject. One hundred twenty-two children 8-18 years old with intermittent asthma, with or without allergic rhinitis, all of whom were monosensitised to house dust mite (HDM) were selected. Sixty two of these children accepted to receive SIT with HDM extract for 4 years and the remaining 60 did not accept SIT and were treated with asthma medications only. This second group of children served as the control group. At the end of the 4-year study period, 36 of the 53 patients (67.9%) in the SIT group showed no new sensitizations, compared to 38 of 52 (73.0%) in the control group (p = 0.141). The most frequent new sensitizations at the end of the study were pollens, grasses and olive polen, followed by animal dander, alternaria and cockroach. In conclusion, SIT may not prevent the onset of new sensitizations in asthmatic children monosensitized to house dust mites. Further investigation is required to clarify the immunologic mechanisms and other factors by which SIT reduces or not the development of new sensitizations in monosensitized children. PMID:20527510
Terrestrial vegetation releases substantial amounts of reactive volatile organic compounds (VOCs; e.g., isoprene, monoterpenes) into the atmosphere. The VOCs can be rapidly photooxidized under conditions of high solar radiation, yielding products that can participate in new particle formation and growth processes above forests. This thesis focuses on the characterization, identification and quantification of oxidation products of biogenic VOC (BVOCs) as well as other species (tracer compounds) that provide information on aerosol sources and source processes. Atmospheric aerosols from various forested sites (i.e., Hyytiala, southern Finland; Rondonia, Brazil; K-Puszta, Hungary and Julich, Germany) were analyzed with Gas Chromotography/Mass Spectrometry (GC/MS) using analytical procedure that targets polar organic compounds. The study demonstrated that isoprene (i.e., 2-methyerythritol, 2-methylthreitol, 2-methylglyceric acid and C5-alkene triols (2-methyl-1,3,4-trihydroxy-l-butene (cis and trans) and 3 methyl-2,3,4-trihydroxy-1-butene)) and monoterpene (pinic acid, norpinic acid, 3-hydroxyglutaric acid and 3-methyl-1,2,3-butanetricarboxylic acid) oxidation products were present in substantial concentrations in atmospheric aerosols suggesting that oxidation of BVOC from the vegetation is an important process in all studied sites. On the other hand, presence of levoglucosan, biomass burning marker, especially in Amazonian rain forest site at Rondonia, Brazil, pointed that all sites were affected by anthropogenic activities, namely biomass burning. Other identified compounds included plyols, arabitol, mannitol and erythritol, which are marker compounds for fungal spores and monosacharides, glucose and fructose, markers for plant polens. Temporal variations as well as mass size distributions of the detected species confirmed the possible formation mechanisms of marker compounds.
Fuchs, Lukas; Koyi, Hemin; Schmeling, Harro
A two-dimensional finite difference code (FDCON) is used to estimate the finite deformation within a down-built diapir. The geometry of the down-built diapir is fixed by using two rigid rectangular overburden units which sink into a source layer of a constant viscosity. Thus, the model refers to diapirs consisting of a source layer feeding a vertical stem, and not to other salt structures (e.g. salt sheets or pillows). With this setup we study the progressive strain in three different deformation regimes within the “salt” material: (I) a squeezed channel-flow deformation regime and (II) a corner-flow deformation regime within the source layer, and (III) a pure channel-flow deformation regime within the stem. We analyze the evolution of finite deformation in each regime individually, progressive strain for particles passing all three regimes, and total 2D finite deformation within the salt layer. Model results show that the material which enters the stem bears inherited strain accumulated from the other two domains. Therefore, finite deformation in the stem differs from the expected channel-flow deformation, due to the deformation accumulated within the source layer. The stem displays a high deformation zone within its center and areas of decreasing progressive strain between its center and its boundaries. High deformation zones within the stem could also be observed within natural diapirs (e.g. Klodowa, Polen). The location and structure of the high deformation zone (e.g. symmetric or asymmetric) could reveal information about different rates of salt supplies from the source layer. Thus, deformation pattern could directly be correlated to the evolution of the diapir.
In patients with respiratory allergy, cross-reactivity between aeroallergens and foods may induce food allergy, symptoms ranging from oral allergy syndrome to severe anaphylaxis. Clinical entities due to IgE sensitization to cross-reactive aeroallergen and food allergen components are described for many sources of plant origin (pollen-food syndromes and associations, such as birch-apple, cypress-peach and celery-mugwort-spice syndromes, and mugwort-peach, mugwort-chamomile, mugwort-mustard, ragweed-melon-banana, goosefoot-melon associations), fungal origin (Alternaria-spinach syndrome), and invertebrate, mammalian or avian origin (mite-shrimp, cat-pork, and bird-egg syndromes). Clinical cases of allergic reactions to ingestion of food products containing pollen grains of specific plants, in patients with respiratory allergy to Asteraceae pollen, especially mugwort and ragweed, are also mentioned, for honey, royal jelly and bee polen dietary supplements, along with allergic reactions to foods contaminated with mites or fungi in patients with respiratory allergy to these aeroallergens. Medical history and diagnosis approach may be guided by the knowledge about the diverse cross-reacting allergens involved, and by the understanding of these clinical entities which may vary significantly or may be overlapping. The association between primary IgE sensitization with respiratory symptoms to inhaled allergens and food allergy due to cross-reactive allergen components is important to assess in allergy practice. The use of molecular-based diagnosis improves the understanding of clinically relevant IgE sensitization to cross-reactive allergen components from aeroallergen sources and foods. PMID:26140270
Kuru, Pinar; Torun, Merve; Halac, Hande Melike; Temiz, Gozde; Iskender, Ece; Karamahmutoglu, Tugba; Idrizoglu, Medine Gulcebi; Onat, Filiz Yilmaz
Toxic honey, containing grayanotoxin, is obtained from nectar and polen of rhododendron. Consumed in excess it produces seizures and convulsions. In order to investigate whether the toxic honey extract can be used as a seizure model, we examined the electroencephalographic (EEG) and motor effects of intracerebroventricular (icv) or intraperitoneal (ip) injection of toxic honey extract in Wistar rats or in genetic absence epilepsy rats from Strasbourg (GAERS). Male Wistar rats or GAERS were stereotaxically implanted with bilateral cortical recording electrodes in all ip groups and cannula in the icv groups. Based on the previous study, an extract was obtained from the non-toxic and toxic honey. After the injection of the non-toxic or toxic honey extract, seizure stages and changes in EEG were evaluated from 9 am to noon. The icv administration of toxic honey extract produced stage 4 seizures and bilateral cortical spikes within 30-60 min and these effects disappeared after 120 min in Wistar rats or GAERS. The mean of bilateral cortical spike acitivity in EEG of Wistar rats was 804.2 ± 261.0 s in the 3-h period. After the icv administration of toxic honey extract to GAERS, the mean duration of spike-and-wave discharges (SWDs) in GAERS significantly decreased during the first 60 min and then returned to baseline level. Ip injection of toxic honey extract caused no seizure and no change in EEG in either GAERS or Wistars. These results suggest that the icv administration of toxic honey extract can be used as a seizure model. PMID:25120202
Miele, M E; Robertson, G; Lee, J H; Coleman, A; McGary, C T; Fisher, P B; Lugo, T G; Welch, D R
Progression of human melanoma toward increasing malignant behavior is associated with several nonrandom chromosomal aberrations, most commonly involving chromosomes 1, 6, 7, 9, and 10. We previously showed that introduction of human chromosome 6 into the highly metastatic human malignant melanoma cell line C8161 completely suppressed metastasis without altering tumorigenicity (Welch DR, Chen P, Miele ME, et al., Oncogene 9:255-262, 1994). Alterations of chromosome 1 are the most frequent chromosome abnormality observed in melanomas, and they frequently arise late in tumor progression. The purpose of the study presented here was to compare the effects of chromosomes 1 and 6 on malignant melanoma metastasis. By using microcell-mediated chromosome transfer, single copies of neo-tagged human chromosomes 1 or 6 were introduced into the human melanoma cell line MelJuSo. The presence of the added chromosome was verified by G banding of karyotypes, fluorescence in situ hybridization, and screening for polymorphic markers on each chromosome. The incidence and number of metastases per lung after intravenous or intradermal injection of parental MelJuSo cells was significantly (P<0.01) greater than those of hybrids containing either chromosome 1 or chromosome 6, although chromosome 1 was a less potent inhibitor of metastasis than chromosome 6. Cultures established from primary tumors and metastases remained neomycin resistant, suggesting that portions of the added chromosomes were retained. These results strengthen the evidence for the presence of a melanoma metastasis suppressor gene on chromosome 6. neo6/MelJuSo hybrids expressed 2.4- to 3.4-fold more of the melanoma differentiation-associated gene mda-6 (previously shown to be identical to WAF1/CIP1/Sdi1/CAP20) than parental metastatic cells. mda-6/WAF1 is among the candidate genes on chromosome 6. These results also demonstrate, for the first time, the existence of metastasis suppressor genes on human chromosome 1, although these genes appear to be less potent than the one encoded on chromosome 6. PMID:8634087
Fedele, Renato; Tanjia, Fatema; Jovanovi?, Dusan; de Nicola, Sergio; Ronsivalle, Concetta; Ronsivalle
The standard classical description of non-laminar charged particle beams in paraxial approximation is extended to the context of two wave theories. The first theory that we discuss (Fedele R. and Shukla, P. K. 1992 Phys. Rev. A 45, 4045. Tanjia, F. et al. 2011 Proceedings of the 38th EPS Conference on Plasma Physics, Vol. 35G. Strasbourg, France: European Physical Society) is based on the Thermal Wave Model (TWM) (Fedele, R. and Miele, G. 1991 Nuovo Cim. D 13, 1527.) that interprets the paraxial thermal spreading of beam particles as the analog of quantum diffraction. The other theory is based on a recently developed model (Fedele, R. et al. 2012a Phys. Plasmas 19, 102106; Fedele, R. et al. 2012b AIP Conf. Proc. 1421, 212), hereafter called Quantum Wave Model (QWM), that takes into account the individual quantum nature of single beam particle (uncertainty principle and spin) and provides collective description of beam transport in the presence of quantum paraxial diffraction. Both in quantum and quantum-like regimes, the beam transport is governed by a 2D non-local Schrödinger equation, with self-interaction coming from the nonlinear charge- and current-densities. An envelope equation of the Ermakov-Pinney type, which includes collective effects, is derived for both TWM and QWM regimes. In TWM, such description recovers the well-known Sacherer's equation (Sacherer, F. J. 1971 IEEE Trans. Nucl. Sci. NS-18, 1105). Conversely, in the quantum regime and in Hartree's mean field approximation, one recovers the evolution equation for a single-particle spot size, i.e. for a single quantum ray spot in the transverse plane (Compton regime). We demonstrate that such quantum evolution equation contains the same information as the evolution equation for the beam spot size that describes the beam as a whole. This is done heuristically by defining the lowest QWM state accessible by a system of non-overlapping fermions. The latter are associated with temperature values that are sufficiently low to make the single-particle quantum effects visible on the beam scale, but sufficiently high to make the overlapping of the single-particle wave functions negligible. This lowest QWM state constitutes the border between the fundamental single-particle Compton regime and the collective quantum and thermal regimes at larger (nano- to micro-) scales. Comparing it with the beam parameters in the existing accelerators, we find that it is feasible to achieve nano-sized beams in advanced compact machines.
Armelius, K; Granberg
Psychotic and borderline patients rated their self-image and their perception of their mother and father using the Structural Analysis of Social Behavior model (SASB). The borderline patients had more negative images of themselves and their parents, especially their fathers, than did the psychotic patients and the normal subjects, while the psychotic patients' ratings did not differ much from those of the normal subjects. The self-image was related to the images of both parents for borderline patients and normal subjects, while for the psychotic patients only the image of the mother was important for the self-image. In addition, the psychotic patients did not differentiate between the poles of control and autonomy in the introjected self-image. It was concluded that borderline patients are characterized by negative attachment, while psychotic patients are characterized by poor separation from the mother and poor differentiation between autonomy and control. The paper also discusses how this may influence the patients' relations to others. Psychotische und Borderline Patienten beurteilten ihr Selbstbild und ihre Wahrnehmung von Mutter und Vater mit Hilfe der strukturalen Analyse sozialen Verhaltens (SASB). Die Borderline Patienten hattten negativere Selbstbilder und Elternbilder (speziell Vaterbilder) als die psychotischen Patienten und gesunde Personen. Die Beurteilungen der psychotischen Patienten unterschieden sich dagegen nicht besonders von jenen Gesunder. Das Selbstbild stand in Beziehung zu beiden Elternbildern bei den Borderline Patienten und den Gesunden, während bei den psychotischen Patienten nur das Mutterbild für das Selbstbild bedeutsam war. Außerdem konnte bei den psychotischen Patienten nicht zwischen den Polen der Kontrolle und Autonomie bzgl. der introjizierten Selbstbilder differenziert werden. Aus den Ergebnissen wird gefolgert, dass Borderline Patienten durch eine negative Bindung charackterisiert sind, psychotische Patienten dagegen durch eine mangelnde Separation von ihren Müttern und eine geringe Differenzierung zwischen Autonomie und Kontrolle. Es wird außerdem diskutiert, wie die Ergebnisse auf die realen Beziehungen der Patienten zu anderen Menschen Einflus nehmen könnten. Des patients psychotiques et Borderline ont évalué leur image d'eux-mêmes et leur perception de leur mère et père à l'aide du modèle de l'Analyse Structural du Comportement Social (SASB. Les patients Borderline avaient des imagess plus négatives d'eux-mêmes et de leurs parents, surtout de leur père, que les patients psychotiques et les sujets normaux, alors que les patients psychotiques se jugeaient à peine différemment des sujets normaux. L'image de soi était en relation avec les images des deux parents pour les patients Borderline et pour les sujets normaux, alors que pour les patients psychotiques, seulement l'image de la mère jouait un rôle pour leur image. En plus, les patients psychotiques ne différenciaient pas entre les pôles de contrôle et d'autonomie dans l'image de soi introjectée. Nous en avons conclu que les patients Borderline se caractérisent par un attachement négatif, et les patients psychotiques par une faible séparation de la mère ainsi qu'une différenciation modeste entre autonomie et contrôle. L'influence de ceci sur les relations des patients avec les autrs est discutée dans cet article. Pacientes limítrofes y psicóticos evaluaron su autoimagen y la percepción que tenían de sus padres usando el modelo de Análisis estructural del comportamiento social (SASB). Los pacientes limítrofes registraron imágenes más negativas de sí mismos y de sus progenitores, especialmente de su padre, que los pacientes psicóticos y los normales, mientras que las evaluaciones de los pacientes psicóticos no difirieron mucho de las de los sujetos normales. La autoimagen tuvo relación con la imagen de ambos progenitores tanto en el caso de los pacientes limítrofes como de los sujetos normales, mientras que para los pacientes psicóticos no diferenciaron entre control y autonomía en la a