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1
Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype
2010-11-02

Recent studies suggest that the human Abelson helper integration site-1 (AHI1) gene on chromosome 6 is associated with susceptibility to schizophrenia and autism, two common neuropsychological disorders with depression symptoms. Mouse Ahi1 protein is abundant in the hypothalamus and amygdala, which are important brain regions for ...

PubMed Central

2
A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia
2010-04-01

The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a ...

PubMed Central

3
Association of common variants in the Joubert syndrome gene (AHI1) with autism
2008-12-15

It has been suggested that autism, like other complex genetic disorders, may benefit from the study of rare or Mendelian variants associated with syndromic or non-syndromic forms of the disease. However, there are few examples in which common variation in genes causing a Mendelian neuropsychiatric disorder has been shown to contribute to disease susceptibility in an allied common condition. ...

PubMed Central

4
Dogs, Foxes, Coyotes, Wolves (family Canidae)

... Helper Integrated Taxonomic Information System (ITIS) Dogs, Foxes, Coyotes, Wolves Animalia Chordata Vertebrata Mammali...

NBII National Biological Information Infrastructure

5
Ahi-1, a novel gene encoding a modular protein with WD40-repeat and SH3 domains, is targeted by the Ahi-1 and Mis-2 provirus integrations.
2002-09-01

The Ahi-1 locus was initially identified as a common helper provirus integration site in Abelson pre-B-cell lymphomas and shown to be closely linked to the c-myb proto-oncogene. Since no significant alteration of c-myb expression was found in Abelson murine leukemia virus-induced pre-B-lymphomas harboring a ...

PubMed

6
Species differences in the expression of AHI1, a protein implicated in the neurodevelopmental disorder Joubert syndrome, with preferential accumulation to stigmoid bodies
2008-11-10

Joubert syndrome (JBTS) is an autosomal recessive disorder characterized by cerebellum and brainstem malformations. Individuals with JBTS have abnormal breathing and eye movements, ataxia, hypotonia, and cognitive difficulty, and they display mirror movements. Mutations in the Abelson-helper integration site-1 gene (AHI1) cause JBTS in humans, suggesting ...

PubMed Central

7
Deregulated expression in Ph+ human leukemias of AHI-1, a gene activated by insertional mutagenesis in mouse models of leukemia.
2004-01-29

Ahi-1/AHI-1 (Abelson helper integration site-1) encodes a family of protein isoforms containing one Src homology 3 (SH3) domain and multiple tryptophan-aspartic acid 40 (WD40)-repeat domains. The function of these proteins is unknown, but involvement in leukemogenesis has been suggested by the high frequency of Ahi-1 mutations seen in ...

PubMed

8
Ahi1, whose human ortholog is mutated in Joubert syndrome, is required for Rab8a localization, ciliogenesis and vesicle trafficking
2009-10-15

The primary non-motile cilium, a membrane-ensheathed, microtubule-bundled organelle, extends from virtually all cells and is important for development. Normal functioning of the cilium requires proper axoneme assembly, membrane biogenesis and ciliary protein localization, in tight coordination with the intraflagellar transport system and vesicular trafficking. Disruptions at any level can induce ...

PubMed Central

9
The Sonoran Bumble Bee Pollintes Desert Plants

... Helper Integrated Taxonomic Information System (ITIS) Sonoran Bumble Bee Animalia Arthropoda Hexapoda Insecta Pterygota Neoptera Hy...

NBII National Biological Information Infrastructure

10
The European Honey Bee Provides Billions of Dollars in Pollination Services

... Taxonomy Helper Integrated Taxonomic Information System (ITIS) European Honey Bee Animalia Arthropoda Hexapoda Insecta Pterygota Neop...

NBII National Biological Information Infrastructure

11
Snowy Plover
2011-09-24

Helper ITIS Logo SOURCE: Integrated Taxonomic Information System (ITIS) Snowy Plover Kingdom: Animalia Phylum: Chordata Subphylum: Vertebrata Class: Aves Order: Ciconiiformes...

Science.gov Websites

12
Rusty Blackbird
2011-09-24

Taxonomy Helper ITIS Logo Integrated Taxonomic Information System (ITIS) Rusty Blackbird Kingdom: Animalia Division: Chordata Subdivision: Vertebrata Class: Aves Order:...

Science.gov Websites

13
Red Knot
2011-09-24

Taxonomy Helper ITIS Logo SOURCE: Integrated Taxonomic Information System (ITIS) Red Knot Kingdom: Animalia Phylum:Chordata Subphylum: Vertebrata Class: Aves Order: Ciconiiformes...

Science.gov Websites

14
Hudsonian Godwit
2011-09-24

Taxonomy Helper ITIS Logo Integrated Taxonomic Information System (ITIS) Hudsonian Godwit Kingdom: Animalia Division: Chordata Subdivision: Vertebrata Class: Aves Order:...

Science.gov Websites

15
Greater Shearwater
2011-09-24

Helper ITIS Logo Integrated Taxonomic Information System (ITIS) Greater Shearwater Kingdom: Animalia Division: Chordata Subdivision: Vertebrata Class: Aves Order:...

Science.gov Websites

16
Another Bumble Bee in Decline: the Yellowbanded Bumble Bee

... Helper Integrated Taxonomic Information System (ITIS) Yellowbanded Bumble Bee Animalia Arthropoda Hexapoda Insecta Pterygota Neoptera...

NBII National Biological Information Infrastructure

17
Alfalfa Leafcutter Bees Are Important Commercial Pollinators of Alfalfa Crops

... Helper Integrated Taxonomic Information System (ITIS) Alfalfa Leafcutter Bee Animalia Arthropoda Hexapoda Insecta Pterygota Neoptera ...

NBII National Biological Information Infrastructure

18
DNA Methylation of Helper Virus Increases Genetic Instability of Retroviral Vector Producer Cells
2000-04-01

Retroviral vector producer cells (VPC) have been considered genetically stable. A clonal cell population exhibiting a uniform vector integration pattern is used for sustained vector production. Here, we observed that the vector copy number is increased and varied in a population of established LTKOSN.2 VPC. Among five subclones of LTKOSN.2 VPC, the vector copy number ranged ...

PubMed Central

19
Propagation of satellite phage P4 as a plasmid.
1982-01-01

Satellite phage P4 has two known options for propagation. In its lytic cycle, its regulatory functions can act in trans to alter the actions of a helper virus (P2), which then provides necessary gene products, including capsid proteins. P4 also can be propagated in the absence of a helper as a prophage, with distinct sites for ...

PubMed Central

20
The transcription factor STAT3 is required for T helper 2 cell development.
2011-01-06

Signal transducer and activator of transcription (STAT) family members direct the differentiation of T helper cells, with specific STAT proteins promoting distinct effector subsets. STAT6 is required for the development of T helper 2 (Th2) cells, whereas STAT3 promotes differentiation of Th17 and follicular helper T�cell subsets. We ...

PubMed

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21
Expression of infectious murine leukemia viruses by RAW264.7 cells, a potential complication for studies with a widely used mouse macrophage cell line
2008-01-04

The mouse macrophage-like cell line RAW264.7, the most commonly used mouse macrophage cell line in medical research, was originally reported to be free of replication-competent murine leukemia virus (MuLV) despite its origin in a tumor induced by Abelson MuLV containing Moloney MuLV as helper virus. As currently available, however, we find that it produces ...

PubMed Central

22
IS&T Colloquium - Hal Abelson - IS&T Colloquium - NASA

Dr. Hal Abelson will talk about Amorphous Computing. Progress in microfabrication and in bioengineering will make it possible to assemble computing systems ...

NASA Website

23
Abelson, Robert Dean - NASA

Jan 22, 2011 ... 9-Dec-2005, A Venus Rover capable of long life surface operations, Evans, Micheal; Shirley, James H.; Abelson, Robert Dean ...

NASA Website

24
MECHANISMS OF HELPER PHAGE. DEPENDENT ...
1968-01-01

... Accession Number : AD0828766. Title : MECHANISMS OF HELPER PHAGE. DEPENDENT TRANSFECTION IN BACILLUS SUBTILIS. ...

DTIC Science & Technology

25
HELPER PHAGE - DEPENDENT TRANSFECTION IN ...
1966-10-01

... Accession Number : AD0803231. Title : HELPER PHAGE - DEPENDENT TRANSFECTION IN BACILLUS SUBTILIS,. Corporate ...

DTIC Science & Technology

26
Community health workers and integrated primary health care teams in the 21st century.

Community health workers are an integral part of many healthcare systems. Their roles vary and include both the socially oriented tasks of natural helpers and specific constrained tasks of health extenders. As natural helpers, community health workers play an important role in connecting public and primary care to the communities that ...

PubMed

27
Construction of a helper cell line for avian reticuloendotheliosis virus cloning vectors
1983-12-01

The authors wished to construct cell lines that supply the gene products of gag, pol, and env for the growth of replication-defective reticuloendotheliosis retrovirus vectors without production of the helper virus. To do this, first they located by S1 mapping the donor and acceptor splice sites of reticuloendotheliosis virus strain A. The donor splice site is ca. 850 base ...

Energy Citations Database

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