Cell cultures prepared from fetal murine liver were infected by Abelson murine leukemia virus. After about 2 weeks, proliferating cells of lymphoid morphology appeared in some of the cultures. Addition of 2-mercaptoethanol to the initial culture medium greatly enhanced the appearance of the lymphoid cells. ...
NASA Astrophysics Data System (ADS)
The genome of Abelson murine leukemia virus (A-MuLV) consists of sequences derived from both BALB/c mouse deoxyribonucleic acid and the genome of Moloney murine leukemia virus. Using deoxyribonucleic acid linear intermediates as a source of retroviral deoxyribonucleic acid, we isolated a ...
Energy Citations Database
murine leukemia retrovirus (Ab-MLV), and in human B cells after infection by hepatitis C virus is recruited to the mouse AID promoter to activate AID expression during infection by Ab-MLV The human AID to infection by a transforming retrovirus, Abelson murine leukemia retrovirus (Ab-MLV). As a ...
E-print Network
member of this family appears to provide a first line of defense against a cancer-causing retrovirus- tended them to show the involvement of APOBEC3G in the cellular response to retroviruses in general to viral infection. Abelson murine leukemia virus (A-MuLV) is a defective retrovirus that does
v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B cells. Transformation requires the phosphatidylinositol 3-kinase (PI3K) pathway. This pathway is antagonized by SH2-containing inositol 5'-phosphatase (SHIP), raising the possibility that v-Abl modulates PI3K signaling through SHIP. ...
PubMed
protects against transformation by Abelson murine leukemia virus (Ab MLV), an oncogenic retrovirus against retroviruses. Similar innate immune functions and corresponding host�pathogen conflicts may.2. APOBEC3G Can Act on a Variety of Viruses 3.2.1. Nonprimate Retroviruses The antiretroviral activity
... Accession Number : ADA464064. Title : Mechanisms of Graft-vs.-Leukemia against a Novel Murine Model of Chronic Myelogenous Leukemia. ...
DTIC Science & Technology
... Accession Number : ADA443726. Title : Mechanisms of Graft-vs.-Leukemia Against a Novel Murine Model of Chronic Myelogenous Leukemia. ...
... Title : Mechanisms of Graft-vs. -Leukemia Against a Novel Murine Model of Chronic Myelogenous Leukemia. Descriptive Note : Annual rept. ...
The mouse macrophage-like cell line RAW264.7, the most commonly used mouse macrophage cell line in medical research, was originally reported to be free of replication-competent murine leukemia virus (MuLV) despite its origin in a tumor induced by Abelson MuLV containing Moloney MuLV as helper virus. As currently available, however, we ...
PubMed Central
Tyrosine kinase inhibitor (TKI) treatment targeting breakpoint cluster region-Abelson murine leukemia virus, the cause of chronic myeloid leukemia (CML), has revolutionized therapy for patients with this disease. The majority of patients with CML maintain favorable responses with long-term imatinib therapy; ...
... 888-INFO-FDA Study: Presence of murine leukemia virus related gene sequences found in CFS patients Researchers have found murine leukemia viruses (MLV) related gene sequences in blood samples collected ...
MedlinePLUS
Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease (MPD) characterized by the expression of the p210-BCR/ABL fusion gene 1. This gene is produced by the reciprocal translocation (9; 22) (q34; q11) that juxtaposes the 3end of Abelson...
National Technical Information Service (NTIS)
Ahi-1/AHI-1 (Abelson helper integration site-1) encodes a family of protein isoforms containing one Src homology 3 (SH3) domain and multiple tryptophan-aspartic acid 40 (WD40)-repeat domains. The function of these proteins is unknown, but involvement in leukemogenesis has been suggested by the high frequency of Ahi-1 mutations seen in certain virus-induced ...
In many tumor systems, analysis of cells for loss of heterozygosity (LOH) has helped to clarify the role of tumor suppressor genes in oncogenesis. Two important tumor suppressor genes, p53 and the Ink4a/Arf locus, play central roles in the multistep process of Abelson murine leukemia virus (Ab-MLV) transformation. p53 and the p53 ...
The gene encoding c-ABL, a nonreceptor protein tyrosine kinase, is involved in a chromosomal translocation resulting in expression of a BCR-Abl fusion protein that causes most chronic myelogenous and some acute lymphocytic leukemias (CML and ALL) in humans. The Abelson murine leukemia virus (A-MuLV) expresses an ...
Activation-induced cytidine deaminase (AID) is expressed in germinal centers of lymphoid organs during immunoglobulin diversification, in bone marrow B cells after infection with Abelson murine leukemia retrovirus (Ab-MLV), and in human B cells after infection by hepatitis C virus. To understand how viruses signal AID induction in the ...
A process unique to lymphocyte differentiation is the rearrangement of genes encoding antigen-specific receptors on B and T cells. A mouse mutant (C.B-17scid) with severe combined immune deficiency, i.e., that lacks functional B and T cells, shows no evidence of such gene rearrangements. However, rearrangements were detected in Abelson murine ...
As the primary effector of immunoglobulin somatic hypermutation (SHM) and class switch recombination (CSR), activation-induced cytidine deaminase (AID) serves an important function in the adaptive immune response. Recent advances have demonstrated that AID and a group of closely related cytidine deaminases, the APOBEC3 proteins, also act in the innate host response to viral infection. Antiviral ...
Normal thymocyte and bone marrow terminal deoxynucleotidyl transferase (TdT) have distinguishing characteristics by phosphocellulose chromatography in Tris buffer: marrow TdT elutes as a single peak at 0.3 M salt, whereas thymocyte TdT separates into two forms, one at 0.3 M salt and one at 0.4 M salt. Since the majority of TdT-positive acute leukemias are anatomically bone ...
... T cells mediate a graft-versus-leukemia effect that is responsible for much of the efficacy of allogeneic hematopoietic stem cell transplantation ...
... We will also study murine models of retrovirus-induced immunosuppression (eg Rauscher leukemia and LP-BM5 virus-induced murine AIDS). ...
Defects in DNA mismatch repair predispose cells to the development of several types of malignant disease. The absence of Msh2 or Mlh1, two key molecules that mediate mismatch repair in eukaryotic cells, increases the frequency of mutation and also alters the response of some cells to apoptosis and cell cycle arrest. To understand the way these changes contribute to cancer predisposition, we ...
Localization of cellular oncogenes (c-onc) near the break points of translocations in tumor cells has indicated involvement of these genes in neoplastic growth. Enhanced transcription of the cellular homolog (c-abl) of the transforming sequence of Abelson murine leukemia virus was observed in K3D, which was one of the cloned cell lines ...
Although imatinib has been used as frontline therapy for chronic myeloid leukemia (CML) for nearly a decade, current debate is focused on the incorporation of newer tyrosine kinase inhibitors (TKIs) at diagnosis in light of recent US Food and Drug Administration approval of nilotinib and dasatinib for initial therapy in chronic-phase CML. Articles were identified through a ...
In patients with chronic myeloid leukemia (CML), the hallmark Philadelphia chromosome is the marker of disease that can be detected by conventional metaphase cytogenetics, fluorescence in situ hybridization, or polymerase chain reaction. The current "gold standard" of treatment response is cytogenetic response. Cytogenetic response to imatinib is strongly associated with ...
The Philadelphia chromosome is the cytogenetic hallmark of human chronic myelogenous leukemia. RNA splicing joins sequences from a gene on chromosome 22 (BCR) across the translocation breakpoint to a portion of the ABL oncogene from chromosome 9, resulting in a chimeric protein (P210) that is an active tyrosine kinase. Although strongly correlated with this specific human ...
Data demonstrating the superiority of nilotinib over imatinib in the frontline treatment of chronic myeloid leukemia (CML) and ongoing studies with dasatinib and bosutinib are rapidly changing the treatment landscape for CML. In this review, the authors discuss currently available therapies for CML, focusing on mechanisms of resistance to imatinib and treatment strategies to ...
A translocation between chromosomes 7 and 9, t(7;9), has been described in cell lines derived from the malignant cells of children with acute T-cell lymphoblastic leukemia or lymphoma. The cytogenetic analysis of one such cell line, SUP-T3, demonstrates that the breakpoints on chromosomes 7 and 9 lie within bands q36 and q34, respectively, corresponding to the location of the ...
... no substance. Goldstein et al. also mention Moloney murine leukemia virus in their letter as a possible factor ... with an upstream immunoglobulin enhancer and a downstream murine leukemia virus long term...
NBII National Biological Information Infrastructure
Concentration and purification of murine leukemia virus for use as complement fixation antigens was accomplished by using a single density gradient in the model RK ultracentrifuge.Images
... Descriptors : *CLINICAL MEDICINE, *LEUKEMIA, *MYELOMA, BIOLOGY, MOLECULES, BIOCHEMISTRY, MUTATIONS, IN VITRO ANALYSIS ...
... Descriptors : *CLINICAL MEDICINE, *LEUKEMIA, *MYELOMA, MOLECULES, BIOCHEMISTRY, MUTATIONS, IN VITRO ANALYSIS, THERAPY ...
... Descriptors : *CLINICAL MEDICINE, *LEUKEMIA, *MYELOMA, MOLECULES, BIOCHEMISTRY, THERAPY, PATIENTS, MICE, PHYSICIANS ...
Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients
galactosidase gene under the promoter control of the Moloney murine leukemia virus long terminal repeat is employed as a particularly preferred embodiment, ...
NASA Website
Because murine leukemia can be transferred by injections of blood from one mouse to another, plus certain evidence suggesting leukemia in human beings to be infectious, this study attempted to determine whether there is a higher incidence of leukemia, (or...
Mice from a wide variety of inbred strains produce immunoglobulin G antibody against murine leukemia virus. This is contrary to the common view that the mouse is immunologically tolerant to its endogenous leukemia virus.
The induction of lymphomas in C57BL mice by methylcholanthrene, urethan, or diethylnitrosamine was accompanied by the development of murine leukemia viral antigen in most of the lymphoid tumors. The cell-free transmission of lymphomas induced by methylcholanthrene and the development of antibody to murine leukemia ...
The murine retroviral models provide in vivo systems with which agents may be tested for their capacity to suppress viremia and retroviral induced disease. The erythrotropic Rauscher murine leukemia virus (RMLV) has been used successfully for the in vivo ...
We have used a soluble in vitro RNA polymerase II transcription system to define the site of initiation of Moloney murine leukemia viral RNA synthesis. Molecularly cloned integrated and unintegrated Moloney murine leukemia virus DNAs were used as templates. The 5' ends of in vitro transcripts and virion RNA of ...
Xenotropic murine leukemia virus-related virus has been detected in blood cells of patients with chronic fatigue syndrome and in 3.7% of healthy controls from the same geographic region. We evaluated 996 men who were participants in the Multicenter AIDS Cohort Study for xenotropic murine leukemia virus-related ...
The only known product of the Snyder-Theilen strain of feline sarcoma virus (ST-FeSV) is a 85,000-dalton protein, designated ST P85, that contains feline leukemia virus gag gene encoded proteins (p15, p12, and a fragment of p30) and a sarcoma virus-specific polypeptide. Antibodies directed against the latter immunoprecipitated a 92,000-dalton phosphoprotein (NCP 92) expressed ...
The 5'-terminal regions of gibbon ape leukemia virus-Hall's Island and Rauscher murine leukemia virus have been completely sequenced. The chain length for the 5'-terminal region of Rauscher murine leukemia virus is 140 nucleotides, and that for gibbon ape leukemia ...
Studies on the genetics of murine and human leukemia revealed striking differences between the two types. The importance of genetic factors in human leukemia was shown by studies on twins, mongols, and other high-incidence groups. The relation of high doses of radiation to leukemogenic activity is pointed out. Analyses of ...
The Ahi-1 locus was initially identified as a common helper provirus integration site in Abelson pre-B-cell lymphomas and shown to be closely linked to the c-myb proto-oncogene. Since no significant alteration of c-myb expression was found in Abelson murine leukemia virus-induced pre-B-lymphomas harboring a ...
, James murine promyelocytic leukemia in hCG-PML/RARA transgenic mice Quantitative trait loci associated Trait Loci Associated with Susceptibility to Therapy- Related Acute Murine Promyelocytic Leukemia in h of RARalpha-PML potentiates the development of PML-RARalpha-driven acute promyelocytic ...
... Expression Profiles of Murine Radiation-Induced Acute Myeloid Leukemia Stem Cells are Similar to Those of Common Myeloid ProgenitorsTokuhisa ... Expression Profiles of Murine Radiation-Induced Acute Myelo...
... A. Lowy, N. Cortez, and S. Silagi. Ecotropic murine leukemia virus-induced fusion of murine cells. J. Virol 57:1048�1054.1986. PubMed, CSAPyra, H., J. Boni, and J. Schupbach. Ultrasensitive retrovirus det...
The favorable graft-versus-leukemia (GVL) effect that occurs after stem cell transplantation suggests that T cells can eradicate leukemia blasts. T cells specifically recognize peptides and exert an antileukemia effect. Several leukemia-associated antigens (LAAs) have been found to be overexpressed in malignant cells from patients with ...
... SUBJECT TERMS Graft-vs.Leukemia, Immunotherapies, Blast Crisis, Tumor Immunology, Ag ... 100 L 1B6 BM alone Figure 1. Radiation-resistant host ...
Murine myeloid leukemia was serially passaged by spleen cell inoculation to provide a possible model for human acute myelocytic leukemia; the original cell donor developed leukemia after irradiation. Leukemic cells obtained early in the course of the disease were less malignant than those obtained from preterminal ...
Cancer.gov
Xenotropic murine leukemia virus-related virus (XMRV) was recently discovered in human prostate cancers and is the first gammaretrovirus known to infect humans. While gammaretroviruses have well-characterized oncogenic effects in animals, they have not be...
... no evidence of XMRV by a variety of techniques. In a separate German study, 1/105 samples from non familial PC cases were found to be positive for XMRV DNA, ...
Center for Biologics Evaluation and Research (CBER)
... Murine Hepatitis Virus (MHV) Model of Spinal Cord Demyelination ... factor 1 or leukemia inhibitory factor, which each prevent loss of mature ...
Examples include Murine Friend Leukemia. Virus transformed ..... to assess spaceflight-induced immune suppression. Additional information may be accessed ...
... Augmentation of virulence of murine coxsackievirus B3 ... Inhibitors or Epstein-Barr virus-induced transformation of ... Leukemia Research 6:711-720. ...
... surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are ... virus entry, also participates in virus-induced cell fusion ...
... Clinical collection sites TBD. access, expertise, geography. Assays. molecular, cultivation/co-cultivation. Organizational Meeting, 4-5 October 2010. ...
... during viral infection or virus-induced neoplastic transformation of ... of primary BALB/c murine embryo fibroblasts. ... nuclease in myeloid leukemia cells. ...
... Control murine 0 ... (ell, HL-60, human promyelocytic leukemia cell; I IA, hemagglutinin; MOI, ... 112 VIRUS-INDUCED LEUCOCYTE ADHERENCE TO ...
We explored the mechanism of cell death of the polymethoxyflavone tangeretin (TAN) in K562 breakpoint cluster region-abelson murine leukemia (Bcr-Abl+) cells. Flow cytometric analysis showed that TAN arrested the cells in the G(2)/M phase and stimulated an accumulation of the cells in the sub-G(0) phase. TAN-induced cell death was ...
A class of mouse neoplasms termed Abelson virus-induced plasmacytoid lymphosarcomas has previously been found to express abnormal myb transcripts due to a helper virus insertion into the 5' end of the c-myb locus. The authors established clonal cell lines from these tumors and have shown that they all express markers characteristic of myelomonocytic, rather than ...
Zebrafish CXC-64, a chemokine representing a superfamily of chemotactic cytokines present in fish, is involved in recruitment, activation, and response to inflammatory stimulation. We cloned and sequenced the genomic DNA of the zebrafish CXC-64 chemokine; it was most similar to CXCL11 from humans and CXCL10 from a catfish. The zebrafish CXC-64 gene is approximately 4.0 kb long and has a four-exon, ...
The novel selective BCR-ABL Breakpoint cluster region--Abelson murine leukemia viral oncogene homolog 1 (BCR-AML) inhibitor nilotinib (AMN107) is a tyrosine kinase inhibitor that is more potent against leukaemia cells in vitro than imatinib. As nilotinib might be used in the context of allogeneic stem cell transplantation where CD8+ T ...
Brain tumors frequently recur or progress as focal masses after treatment with ionizing radiation. However, the mechanisms underlying the repopulation of tumor cells after radiation have remained unclear. In this study, we show that cellular signaling from Abelson murine leukemia viral oncogene homolog (Abl) to protein kinase C? (PKC?) ...
Here we present the principle of fluorescence in situ hybridization (FISH) with combinatorial oligonucleotide (COMBO) probes as a new approach for the specific labeling of genomic sites. COMBO-FISH takes advantage of homopurine/homopyrimidine oligonucleotides that form triple helices with intact duplex genomic DNA, without the need for prior denaturation of the target sequence that is usually ...
A new strain of Friend recombinant mink cell focus-inducing retrovirus, FMCF -1-E, was found to induce leukemias in NFS and IRW mice. Although the isolate was obtained from a stock of FMCF -1 ( Troxler et al., J. Exp. Med. 148:639-653, 1978), FMCF -1-E was distinguishable from FMCF -1 by oligonucleotide fingerprinting and antigenic analysis, using monoclonal antibodies. These ...
Xenotropic murine leukemia virus�related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using PCR. XMRV-specific sequences were detected in 2%�3% of samples from 168 immunocompetent carriers and ?10% of samples from 161 ...
The invention relates to Friend murine leukemia virus (F-MuLV) specific monoclonal antibodies, or binding fragments thereof, specific for an antigenic determinant of a gp85 envelope precursor protein characteristic of a methanol-fixed F-MuLV infected cell...
Heterogeneity of buoyant density and RNA content of virions of Moloney murine leukemia-sarcoma complex (MSV(MLV)) was the result of passage at low dilution. Heterogeneous stocks revealed two major RNA components in the population, with the smaller compone...
Since the first isolation of a murine leukemia, it has been noted that transmission of the leukemic disease is very much dependent on the mouse strain selected for the virus inoculation. There are many different genetic determinants that may render the mo...
Murine L1210 leukemia cells spontaneously produce very low amounts of colony stimulating factor (CSF). CSF production was markedly increased by stimulating L1210 cells with lipopolysaccharide, lectins, and sheep red blood cells. From the conditioned medium of phytohemagglutinin-stimulated L1210 cells we isolated a CSF with an apparent molecular weight of ...
Analysis of genomic and expression data allows both identification and characterization of novel retroviruses. We describe a recombinant type C murine retrovirus, similar to the Mus dunni endogenous retrovirus, with VL30-like long terminal repeats and murine leukemia virus-like coding sequences. This virus is present in multiple copies ...
The leukemogenic activity of Gross murine leukemia virus adapted to rats was tested in W/Fu rats and NIH/Swiss mice. All animals infected with this virus developed thymic and nonthymic T-cell leukemia with a short latency period. It was observed that cell-free extracts from thymic lymphoma tissue of mice and rats, induced by either ...
A human homologue of the recently cloned murine leukemia-inhibitory factor (LIF) gene was isolated from a genomic library by using the marine cDNA as a hybridization probe. The nucleotide sequence of the human gene indicated that human LIF has 78% amino acid sequence identity with murine LIF, with no insertions or deletions, and that ...
A challenge for the development of therapies selectively targeting leukemic stem cells in acute myeloid leukemia (AML) is their similarity to normal hematopoietic stem cells (HSCs). Here we demonstrate that the leukemia-propagating cell in murine CALM/AF10-positive AML differs from normal HSCs by B220 surface expression and ...
Retroviral expression of leukemogenic oncogenes in the murine hematopoietic system is essential but not sufficient to induce acute leukemia. Proviral integration-mediated elevated expression of the meningioma 1 (MN1) oncogene suggested MN1 acting as cooperating event in mixed-lineage leukemia 1 (MLL) and eleven nineteen ...
RAW264 cells, reported to be originated from Abelson-virus-induced B lymphomas, are widely used as a murine monocyte cell line. We found that RAW264 show enhanced expression of murine N-MYC. Murine cDNA clones associated with N-MYC were separated from (lambda)gt11 cDNA library constructed by using mRNA from the ...
Ikaros is a zinc finger transcriptional regulator encoded by the Ikzf1 gene. Ikaros displays crucial functions in the hematopoietic system and its loss of function has been linked to the development of lymphoid leukemia. In particular, Ikaros has been found in recent years to be a major tumor suppressor involved in human B-cell acute lymphoblastic ...
A review is presented on mice leukomogenesis. Mice of all strains are generally susceptible to leukemia induction by radiation and nearly all experimental work is carried out on these species. The same kinds of leukemia can also be produced in rats, but the Chinese hamster is strikingly more resistant to leukemogenesis by radiation than the ...
The antitumor activity of 2'-deoxy-2'-methylidenecytidine (DMDC), an inhibitor of DNA synthesis, was examined and compared with that of 1-beta-D-arabinofuranosylcytosine (ara-C) against various murine tumors and human tumor xenografts. Against P388 murine leukemia, repeated treatments of DMDC were more effective than its single ...
The Graffi murine leukemia virus induces a large spectrum of leukemias in mice and thus provides a good model to compare the transcriptome of all types of leukemias. We analyzed the gene expression profiles of both T and B leukemias induced by the virus with DNA microarrays. Given that we ...
We report the molecular cloning of two replication-competent osteoma-inducing murine leukemia viruses from the RFB osteoma virus stock (M. P. Finkel, C. A. Reilly, Jr., B. O. Biskis, and I. L. Greco, p. 353-366, in C. H. G. Price and F. G. M. Ross, ed., Bone--Certain Aspects of Neoplasia, 1973). Like the original RFB osteoma virus stock, viruses derived ...
Important biological and pathological properties are often conserved across species. Although several mouse leukemia models have been well established, the genes deregulated in both human and murine leukemia cells have not been studied systematically. We performed a serial analysis of gene expression (SAGE) analysis on gene expression ...
Thioredoxin-interacting protein (TXNIP) is involved in reactive oxygen species-induced stress responses. In a screen for novel disease genes in murine leukemia virus (MLV)-induced mouse leukemias, we identified Txnip as a frequent target for proviral integration. Ectopic TXNIP expression inhibited the proliferation of myeloid ...
Researchers have not found evidence that XMRV causes any diseases in humans or in animals. The presence of an infectious agent, such as a virus, in diseased tissue does not mean that the agent causes the disease.
A variety of immunological reagents including MAbs directed at the proteins of MuLVs are known. These include MAbs specific for certain ecotropic, xenotropic and polytropic MuLVs from inbred mice and MAbs reactive with ecotropic viruses of feral mice. The...
, somato- lactin, and placental lactogen family and is synthesized predominantly by the somatotrophs RNA using oligo(dT)15 (MWG-Biotech, Ebers- burg, Germany) and Moloney-murine leukemia virus (M
Studies on murine, feline, and ungulate retroviruses have provided background and direction for much of the research on human retroviruses and the pathogenesis of leukemia and immunosuppression. The relevance of animal model systems for retroviral induced...
A preparative method for isolating pure viral envelopes from a type-C RNA tumor virus, Rauscher murine leukemia virus, is described. Fractionation of virions of Rauscher murine leukemia virus was studied after disruption of the virions with the detergents sodium dodecyl sulfate of Nonidet P-40 in combination with ...
fecal microflora and murine virus antibody of mice maintained ... a slow virus infection was studied using Friend Leukemia virus ... Vaccine Induced Immunity. D-l. E. Influenza Cross Infection Among Mice Maintained ...
... uterus include heparin-binding epidermal growth factor (EGF), leukemia inhibitory factor, COX-2, specific integrins, and metalloproteinase ... cell survival assays were performed using wild-type murine ti...
... 28. Sarbassov DD, Ali SM, Kim DH, et al. Rictor, a novel binding partner of in murine leukemia virus-induced tumors. Cell 1989;56:673-82. ...
... 5. What did the new study conclude? ... What do these findings mean to CFS patients and clinicians who ... in a high percentage of CFS patients, this does not prove ...
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The Goff laboratory is interested in the replication of a simple retrovirus, the Moloney murine leukemia virus, and the interaction of the virus with the host. The ultimate goal of the research is to determine the roles of each of the viral proteins in the complex viral life cycle, and to identify the impact of these proteins on host cellular machinery.
... E. Dufrasne, and J. Delcourt. Stimulatory and inhibitory effects of glucose and insulin on rat blastocyst development in vitro. Diabetes 1991. 40:641�647. CrossRef, PubMedSjoblom, C., M. ... ...
The defined mapping of the MuLV integrase in previous work (10,11) has made it possible for us to design and construct molecular clones for expression of this protein in bacteria and thus easily obtain specific antisera. Our repeated inability to isolate ...
... well as over 50 recombinant cytokines from other animal models (R&D Systems, personal communication). Based on our current data, we cannot explain ... ...
During year 03, significant progress has been made in this project. Using the cost effective mouse model involving Rauscher murine leukemia virus (RLV), we have demonstrated that DNA vaccination can induce protection against virus challenge, even when the...
... is known to act on several types of stem cells originating from various organs. Indeed, LIF was first identified through its ability to maintain murine embryonic stem cells in their undifferentiated totipo...
... Leukemia 18: 771-776. ... Frey and collaborators have shown that murine CD8 TIL ... of Health), MBL2 (H-2b) a Moloney virus-induced lymphoma, and ...
In the past decade, a large amount of effort has gone into the development of hit size effectiveness functions (HSEFs), with the ultimate aim of replacing the present absorbed dose-RBE-Q system. However, the absorbed dose determined at the tissue level is...
Effective gene therapy for musculoskeletal injuries requires the optimization of the components and techniques for the accurate assessment of therapeutic benefits. We have identified a murine leukemia virus (MLV) vector that provides robust transgene expr...
... Satterfield B, Garcia R, Gurrieri F, Schwartz C. PCR and serology find no association between xenotropic murine leukemia virus-releated virus and autism. ...
Neurodegeneration induced by PVC-211 murine leukemia virus is associated with increased levels of vascular endothelial growth factor and macrophage inflammatory protein 1 alpha and is inhibited by blocking activation of microglia. J. Virol.
... murine leukemia virus constitutively released from the human B- ... 5 Mus musculus BAC clone RP24-131B6 from chromosome 1, complete sequence ...
The present invention consists of derivatives of colchicine and thiocolchicine which are carbamates of the same. These compounds are not only new but have exhibited antitumor activity binding to tubulin protein and tests against P388 lymphocytic leukemia ...
this message, please visit this page: About CDC.gov. XMRV (Xenotropic Murine Leukemia Virus-related Virus) XMRV Home Questions & Answers Updates XMRV virus particles XMRV virus...
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The patholoBy of bone marrow depression in mice with lymphoma and lymphoid leukemia is discussed. Results are reported from studies whioh indicate the involvement of both the sex hormone system and a lymphocytosisstimulating factor. (C. H.)
