protein tyrosine kinase, in the regulation of Rac activation and Rac-dependent actin remodeling (17, 18 protein tyrosine kinase (22), Abi-1 may also connect WAVE2 with Abl. To address this possibility, Abi-1-1�WAVE2 interaction is enhanced by the tyrosine phosphorylation of one or both of ...

The authors report their molecular characterization of the Drosophila melanogaster Abelson gene (abl), a gene in which recessive loss-of-function mutations result in lethality at the pupal stage of development. This essential gene consists of 10 exons extending over 26 kilobase pairs of genomic DNA. The DNA sequence encodes a protein of 1,520 amino acids with strong sequence ...