Cell cultures prepared from fetal murine liver were infected by Abelson murine leukemia virus. After about 2 weeks, proliferating cells of lymphoid morphology appeared in some of the cultures. Addition of 2-mercaptoethanol to the initial culture medium greatly enhanced the appearance of the lymphoid cells. Immunoglobulin determinants were evident on the ...

murine leukemia retrovirus (Ab-MLV), and in human B cells after infection by hepatitis C virus is recruited to the mouse AID promoter to activate AID expression during infection by Ab-MLV The human AID to infection by a transforming retrovirus, Abelson murine leukemia retrovirus (Ab-MLV). As a result of AID

In many tumor systems, analysis of cells for loss of heterozygosity (LOH) has helped to clarify the role of tumor suppressor genes in oncogenesis. Two important tumor suppressor genes, p53 and the Ink4a/Arf locus, play central roles in the multistep process of Abelson murine leukemia virus (Ab-MLV) transformation. p53 and the p53 ...

v-Abl protein tyrosine kinase encoded by Abelson murine leukemia virus (Ab-MLV) transforms pre-B cells. Transformation requires the phosphatidylinositol 3-kinase (PI3K) pathway. This pathway is antagonized by SH2-containing inositol 5'-phosphatase (SHIP), raising the possibility that v-Abl modulates PI3K signaling ...

protects against transformation by Abelson murine leukemia virus (Ab MLV), an oncogenic retrovirus against retroviruses. Similar innate immune functions and corresponding host�pathogen conflicts may.2. APOBEC3G Can Act on a Variety of Viruses 3.2.1. Nonprimate Retroviruses The antiretroviral activity

Expression of ornithine decarboxylase (ODC), the initial enzyme is polyamine biosynthesis, is essential for cell growth. The Abelson virus-transformed, murine macrophage-derived RAW264 cell line, overexpresses ODC activity and enzyme protein at a level 100-1000-fold greater than in normal cells. Expression of ODC was completely dependent on extracellular ...

Defects in DNA mismatch repair predispose cells to the development of several types of malignant disease. The absence of Msh2 or Mlh1, two key molecules that mediate mismatch repair in eukaryotic cells, increases the frequency of mutation and also alters the response of some cells to apoptosis and cell cycle arrest. To understand the way these changes contribute to cancer predisposition, we ...

... cell lines (Abelson transformed lines or hybridomas) derived scribed in detail (16). ... thus, may preferentially yield hybridomas. only, or Igh-6a/6b. ...

This book includes chapters on the following topics: The structure, function, and genetics of Human Class II Molecues; The complexity of virus-cell interactions in Abelson Virus Infection of Lymphoid and other Hematpoletic cells; and the Epstein-Barr Virus and immunoregulation in man.

The only known product of the Snyder-Theilen strain of feline sarcoma virus (ST-FeSV) is a 85,000-dalton protein, designated ST P85, that contains feline leukemia virus gag gene encoded proteins (p15, p12, and a fragment of p30) and a sarcoma virus-specific polypeptide. Antibodies directed against the latter immunoprecipitated a ...

The genome of Abelson murine leukemia virus (A-MuLV) consists of sequences derived from both BALB/c mouse deoxyribonucleic acid and the genome of Moloney murine leukemia virus. Using deoxyribonucleic acid linear intermediates as a source of retroviral deoxyribonucleic acid, we isolated a recombinant plasmid which contained 1.9 ...

As the primary effector of immunoglobulin somatic hypermutation (SHM) and class switch recombination (CSR), activation-induced cytidine deaminase (AID) serves an important function in the adaptive immune response. Recent advances have demonstrated that AID and a group of closely related cytidine deaminases, the APOBEC3 proteins, also act in the innate host response to viral infection. Antiviral ...

A process unique to lymphocyte differentiation is the rearrangement of genes encoding antigen-specific receptors on B and T cells. A mouse mutant (C.B-17scid) with severe combined immune deficiency, i.e., that lacks functional B and T cells, shows no evidence of such gene rearrangements. However, rearrangements were detected in Abelson murine leukemia ...

... of the experimental transformation of the variola virus into vaccinia virus. However, does this say that the vaccinia and variola viruses have a ...

... Abstract : Quantitative transformation assays detecting morphological transformation of Swiss mouse 3T3 cells by herpes simplex virus type 2 were ...

A class of mouse neoplasms termed Abelson virus-induced plasmacytoid lymphosarcomas has previously been found to express abnormal myb transcripts due to a helper virus insertion into the 5' end of the c-myb locus. The authors established clonal cell lines from these tumors and have shown that they all express markers ...

The following topics are reviewed: transformation of hamster embryo cells by herpes simplex viruses and human cytomegalovirus; the use of uv radiation and photodynamic action to inactivate virus infectivity while retaining the transformation potential of the virus; detection of ...

member of this family appears to provide a first line of defense against a cancer-causing retrovirus- tended them to show the involvement of APOBEC3G in the cellular response to retroviruses in general to viral infection. Abelson murine leukemia virus (A-MuLV) is a defective retrovirus that does

Effects of radiation on animal viruses are reviewed in terms of repair mechanisms and their possible relationship to virus transformation and carcinogenesis. Repair mechanisms are reviewed under the headings; multiplicity reactivation, photoreactivation, host-cell reactivation (dark repair), and uv reactivation. Other topics ...

The gene encoding c-ABL, a nonreceptor protein tyrosine kinase, is involved in a chromosomal translocation resulting in expression of a BCR-Abl fusion protein that causes most chronic myelogenous and some acute lymphocytic leukemias (CML and ALL) in humans. The Abelson murine leukemia virus (A-MuLV) expresses an alternative form of c-Abl, v-Abl, that ...

Quantitative transformation assays detecting morphological transformation of Swiss mouse 3T3 cells by herpes simplex virus type 2 were employed to detect transformation enhancement by potentially mutagenic and carcinogenic chemicals. Hydrazine and 1,2-dim...

A temperature sensitive RNA tumour virus mutant has been isolated whose properties indicate that part of the viral genome is required for transformation but not for growth.

5 days ago ... The Friend Leukemia Virus Transformed Cells Exposed to Microgravity in the Presence of DMSO (FRIEND) experiment was flown as part of Biorack ...

... TITLE: Effect of Chemical Mutagens on Herpes Virus - Induced Cellular Transformation and Testinq for Mutagenesis in Mouse Cells ...

Localization of cellular oncogenes (c-onc) near the break points of translocations in tumor cells has indicated involvement of these genes in neoplastic growth. Enhanced transcription of the cellular homolog (c-abl) of the transforming sequence of Abelson murine leukemia virus was observed in K3D, which was one of the cloned cell lines ...

Zebrafish CXC-64, a chemokine representing a superfamily of chemotactic cytokines present in fish, is involved in recruitment, activation, and response to inflammatory stimulation. We cloned and sequenced the genomic DNA of the zebrafish CXC-64 chemokine; it was most similar to CXCL11 from humans and CXCL10 from a catfish. The zebrafish CXC-64 gene is approximately 4.0 kb long and has a four-exon, ...

A translocation between chromosomes 7 and 9, t(7;9), has been described in cell lines derived from the malignant cells of children with acute T-cell lymphoblastic leukemia or lymphoma. The cytogenetic analysis of one such cell line, SUP-T3, demonstrates that the breakpoints on chromosomes 7 and 9 lie within bands q36 and q34, respectively, corresponding to the location of the gene encoding the ...

The Philadelphia chromosome is the cytogenetic hallmark of human chronic myelogenous leukemia. RNA splicing joins sequences from a gene on chromosome 22 (BCR) across the translocation breakpoint to a portion of the ABL oncogene from chromosome 9, resulting in a chimeric protein (P210) that is an active tyrosine kinase. Although strongly correlated with this specific human neoplasm, and implicated ...

The volume contains information on antiviral procedures; detection, isolation and transmission of viruses; cancer virus morphology and replication methods of transformation; host-virus interaction; viral carcinogenesis; and other epidemiological studies. ...

... ASSAYING, TRANSFORMATIONS, VIRUSES, EMBRYOS, MICE, FORWARD AREAS, MUTATIONS, CELLS, RATS, LYMPHOMAS, LEUKEMIA. ...