Angiogenesis is an important issue in cancer research and opioids are often used to treat pain in cancer patients. Therefore it is important to know if the use of opioids is associated with an aberrant stimulation of tumor growth triggered by the stimulation of angiogenesis in cancer patients. Some studies in the literature have ...
PubMed Central
to explore heritable factors operating in experimental models of retinopathy of prematurity, an eye disease that affects some premature infants. The condition is caused by aberrant angiogenesis. The methodologies
E-print Network
Chronic inflammation is tightly linked to diseases associated with endothelial dysfunction including aberrant angiogenesis. To better understand the endothelial role in pro-inflammatory angiogenesis, we analyzed signaling pathways in continuously activated endothelial cells, which were either chronically exposed to soluble TNF or the ...
PubMed
... data, is that inhaled nitric oxide in the preterm neonate will act by decreasing airway muscularization and improve pulmonary angiogenesis and alveolarization ...
Center for Drug Evaluation (CDER)
Kaposi's sarcoma (KS) is the major AIDS-associated malignancy. It is characterized by the proliferation of spindle cells, inflammatory infiltrate, and aberrant angiogenesis caused by Kaposi's sarcoma herpesvirus (KSHV) infection. Small GTPase Rac1, an inflammatory signaling mediator triggering reactive oxygen species (ROS) production by NADPH-oxidases, is ...
... RR1926.1 Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative StressMark W. Dewhirst1Radiation Oncology Depa...
NBII National Biological Information Infrastructure
-oxide can be detected in vivo by cardiac MRI (Garot et al. 2003). Cancer, receptors and angiogenesis have
... Expression of Oxygen-Binding Proteins in Antarctic Fishes Affecting Nitric Oxide-Mediated Pathways of Angiogenesis and Mitochondrial Biogenesis. ...
NASA Website
We investigated the occurrence, origin and have begun to explore the biological function of elevated reactive oxygen species (ROS) in breast carcinoma cell lines, particularly with regard to aberrant expression of Nox isoforms. We have initially surveyed ...
National Technical Information Service (NTIS)
HypothesisImpaired wound healing in diabetics is due to pathological angiogenesis, which is a result of aberrant sphingosine-1-phosphate (S1P) signaling. Pharmacological modulation of sphingosine-1-phosphate-dependent signaling normalizes healing in diabetic wounds.
Human breast cancer genesis and progression is caused by the aberrant function of genes that positively and negatively regulate aspects of cell proliferation, apoptosis, genome stability, angiogenesis, invasion and metastasis( 1). Discovery and functional...
The growth of new blood vessels (angiogenesis) is critical for tumor growth and progression. The highly conserved Notch signaling pathway is involved in a variety of cell fate decisions and regulates many cellular biological processes, including angiogenesis. Aberrant Notch signaling has also been implicated in tumorigenesis. Notch ...
... with hypertensive crisis, has been shown to promote angiogenesis. However, direct evidence showing the involvement of NO in the SNP-induced angiogenesis is not available. Accordingly, we assessed whether N...
We have recently shown that aldose reductase (AR, EC 1.1.1.21) a nicotinamide adenine dinucleotide phosphate-dependent aldo-keto reductase, known to be involved in oxidative stress-signaling, prevents human colon cancer cell growth in culture as well as in nude mice xenografts. Inhibition of AR also prevents azoxymethane-induced aberrant crypt foci ...
Results are reported from a study of the effects of nitric oxide concentration on the radiosensitivity of root tips of the broad bean, Vicia faba, as demonstrated by chromosomal aberrations. (C.H.)
Energy Citations Database
The exact mechanism for the formation of aberrant chromosomes and persistent nucleoli by 4-nitroquinoline 1-oxide is not known, although much speculations have been made on the inhibitory effect of this carcinogen and its derivatives on cellular DNA, RNA,...
The past ten years parallels have been drawn between the biology of cancer and pulmonary fibrosis. The unremitting recruitment and maintenance of the altered fibroblast phenotype with generation and proliferation of immortal myofibroblasts is reminiscent with the transformation of cancer cells. A hallmark of tumorigenesis is the production of new blood vessels to facilitate tumor growth and ...
This Failla Lecture focused on the inter-relationships between tumor angiogenesis, HIF-1 expression and radiotherapy responses. A common thread that bonds all of these factors together is microenvironmental stress caused by reactive oxygen and nitrogen species formed during tumor growth and angiogenesis or in response to cytotoxic treatment. In this review ...
Collaborative Research: Differential Expression of Oxygen-binding Proteins in Antarctic Fishes Affects Nitric Oxide-mediated Pathways of Angiogenesis and ...
Dec 6, 2009... of Oxygen-binding Proteins in Antarctic Fishes Affects Nitric Oxide-mediated Pathways of Angiogenesis and Mitochondrial Biogenesis ...
Angiogenesis has a critical role in physiologic and disease processes. For the growth of tumors, angiogenesis must occur to carry sufficient nutrients to the tumor. In addition to growth, development of new blood vessels is necessary for invasion and metastases of the tumor. A number of strategies have been developed to inhibit tumor ...
BackgroundIrregular uterine bleeding is the major side effect of, and cause for, discontinuation of long-term progestin-only contraceptives (LTPOCs). The endometria of LTPOC-treated women display abnormally enlarged, fragile blood vessels (BV), decreased endometrial blood flow and oxidative stress. However, obtaining sufficient, good quality tissues have precluded elucidation ...
Numerous studies have described the process of senescence associated with accumulation of oxidative damage, mutations and decline in proliferative potential. Although the changes observed in senescent cells are likely to result in significant phenotypic alterations, the studies on consequences of endothelial senescence, especially in relation to aging-associated diseases, are ...
