... CANCER, EPITHELIUM, NEOPLASMS, VECTOR ANALYSIS, GENES, CELLS(BIOLOGY), LESIONS, TETRACYCLINES, PITUITARY HORMONES. ...
DTIC Science & Technology
... FIBROSIS, *NEUROBIOLOGY, MUTATIONS, MOLECULAR BIOLOGY, GENES, CELLS(BIOLOGY), PERIPHERAL NEUROPATHY, ONCOGENESIS ...
We hypothesized that aberrant expression of Hox genes in mammary epithelial cells results in the inappropriate regulation of a wide variety of Hox target genes; this could lead to a change from a normal to a preneoplastic, or from a preneoplastic to a neo...
National Technical Information Service (NTIS)
The expression of protein kinases genes if often altered in tumors. The aberrant expression of several of these genes typically parallels the progression toward a more malignant phenotype. We developed a cDNA micro-array- based screening system to mearuse...
The expression of genes involved in signal transduction (e.g. protein kinases) is often altered in tumors. The aberrant expression of several of these genes typically parallels the progression toward a more malignant phenotype. We developed a cDNA micro-a...
... NERVE CELLS, GENES, FIBROBLASTS, CELLS(BIOLOGY), SKIN(ANATOMY), FIBROSIS, PERIPHERAL NEUROPATHY, ONCOGENESIS. ...
... expression in prostate tumor cells was quite different than in other cell types, and prostate Ets family expression relative to other tissues was ...
The TSPY gene is the only functional gene within the critical region harboring the gonadoblastoma locus on the Y chromosome (GBY). Expression studies demonstrated that it is aberrantly expressed in prostate cancer. This project is designed to address the ...
... KNOWN EXPRESSIONS FOR THE ABERRATIONS OF PLANE ... CAN CONSIDERABLY REDUCE THE SPHERICAL ABERRATION AND COMA ...
... Thus, loss of CEACAMI tumor suppressor gene expression in prostate cancer is due to aberrant chromatin acetylation. ...
... association between SNCG protein expression in primary ... sequencing and methylation-specific PCR assays, we ... CpG island of SNCG gene in every ...
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor of the observation that loss of PTEN, the negative regulator of PI3K, results in robust activation of this pathway)-detectable PTEN loss in breast cancer (BC). The most significant signature gene was PTEN itself, ...
E-print Network
Polymorphic epithelial mucin (PEM), the product of the MUC1 gene, is expressed in an aberrant form by human breast cancer cells. It is a known, potential target for cytotoxic T lymphocytes of patients with the disease. Cloning of the MUC1 gene and the dev...
.elsevier.com/locate/lungcan Chromosomal aberrations and gene expression profiles in non-small cell lung cancer E. Dehana , A. Ben-Dorb , W 2006 KEYWORDS Non-small cell lung cancer; Chromosomal aberrations; Expression profiling; Expression results provide a high resolution ...
Copy number aberration is a common form of genomic instability in cancer. Gene expression is closely tied to cytogenetic events by the central dogma of molecular biology, and serves as a mediator of copy number changes in disease phenotypes. Accordingly, it is of interest to develop proper statistical methods for jointly analyzing copy ...
PubMed
AbstractCopy number aberration is a common form of genomic instability in cancer. Gene expression is closely tied to cytogenetic events by the central dogma of molecular biology, and serves as a mediator of copy number changes in disease phenotypes. Accordingly, it is of interest to develop proper statistical methods for jointly ...
PubMed Central
HOX genes encode a large family of transcription factors involved in key developmental decisions, and are often aberrantly expressed in cancer. Our laboratory has previously shown that a subset of genes of the HOXC cluster are overexpressed in primary pro...
Our hypothesis that the human PPC-1 prostate tumor cell lines with experimentally altered Ets transcription factor function, which show a reduction in the transformed phenotype, do so because of altered expression patterns in important genes downstream of...
Glutathiaone-s-transferase (GST)-Pi gene is frequently methylated in prostate cancer and recent evidence has linked aberrant expression of this gene with the development of prostatic adenocarcinomas (PACs). The main purpose of this study is to evaluate GS...
... dosage compensation of the X-linked gene transcripts G6PD, PGK, and Xist in preimplantation bovine embryos. Biol ... ...
NBII National Biological Information Infrastructure
Human breast cancer is characterized by the altered expression of growth factors, growth factor receptors and kinases. Downstream effectors of these molecules are transcription factors which presumably control aberrant gene expression regulating cell grow...
This paper addresses the clustering and classification of active genes during the process of cell division. Cell division ensures the proliferation of cells, but becomes drastically aberrant in cancer cells. The studied genes are described by their expression profiles (i.e. time series) during the cell division ...
NASA Astrophysics Data System (ADS)
Endometrial cancer is the most commonly diagnosed gynecological cancer, and it has been shown to be a complex disease driven by abnormal genetic, and epigenetic alterations, as well as environmental factors. Epigenetic changes resulting in aberrant gene expression are dynamic and modifiable features of many cancer types. A significant ...
AbstractThe maspin gene functions as a tumor suppressor in human breasts, and its expression is frequently lost during breast cancer progression. In vitro models of human breast cancer indicate that the loss of maspin expression is closely linked to aberrant methylation of the maspin promoter. We conducted a study ...
... EACH SHAPED FOR MINIMUM SPHERICAL ABERRATION. THESE EXPRESSIONS INCLUDE THE PRIMARY ABERRATIONS AND THE ...
The important role of insulin-like growth factor binding protein 7 (IGFBP7) as a tumor suppressor in solid tumors has been revealed in several studies. Interestingly, in a recent study IGFBP7 was also shown to be aberrantly expressed in acute leukemia. Moreover, in acute T-lymphoblastic leukemia (T-ALL), high IGFBP7 expression predicts ...
Breast cancer specific gene 1 (BCSG1) is not expressed in normal breast tissue but is highly expressed in the vast majority of invasive and metastatic breast carcinomas. When over expressed, BCSG1 significantly stimulates the proliferation and invasion of...
Gene expression studies have shown that expression patterns of several genes have changed during the development of alcoholism. Gene expression is regulated not only at the level of transcription but also through alternative splicing of pre-mRNA. In this review, we discuss ...
The relationship of aberrant DNA hypermethylation of cell cycle checkpoint genes with the sensitivity of cancer cells to anticancer drugs is a question of current interest. In this study, we investigated the relationship between aberrant hypermethylation of the CHFR (checkpoint with forkhead-associated and ring finger) mitotic ...
Amplified cellular genes are frequently manifested in one of two cytologically recognizable forms, double minutes or homogeneously staining regions. Additionally, evidence is accumulating that aberrant expression of cellular genes (including oncogenes) may be mediated by gene amplification. The ...
Energy Citations Database
It is now well established that the interplay of sequence-specific DNA binding proteins with chromatin components and the subsequent expression of differential genetic programs is the major determinant of developmental decisions. The last years have seen an explosion of basic research that has significantly enhanced our understanding of the basic principles of ...
MicroRNAs (miRNAs) represent a novel class of small RNA molecules that play a crucial role as post-transcriptional regulators of gene expression. As evidence for the involvement of miRNAs in various cellular processes increases, it is important to examine how miRNAs regulate gene expression. In the pituitary, ...
... if the value was less than 1, the inverse was used as the fold decrease. To calculate the fold change for each normal control, the mean values were calculated from the data ... ...
The hypothesis to be tested in this proposal was that soy metabolites selectively eliminate aberrant breast epithelial cells (tumor cells) by altering the expression of specific cell cycle regulatory genes which, in turn, causes cell cycle arrest and indu...
The skin is an organ that is highly sensitive to chronic arsenic exposure. Skin lesions such as hyperkeratoses (HKs), which are characterized by hyperproliferation and aberrations in terminal epidermal differentiation, are common early manifestations of arsenicosis in humans. H...
EPA Science Inventory
Targeted deletion of the bZIP transcription factor, C/EBPbeta, was shown previously to result in aberrant ductal morphogenesis and decreased lobuloalveolar development, accompanied by an altered pattern of progesterone receptor (PR) expression. Similar ch...
Overall, this study is based on the hypothesis that the human PPC-1 prostate tumor cell line with experimentally altered Ets transcription factor function, which show a reduction in the transformed phenotype, do so because of altered expression patterns i...
Structural chromosome aberrations are hallmarks of many human genetic diseases. The precise mapping of translocation breakpoints in tumors is important for identification of genes with altered levels of expression, prediction of tumor progression, therapy...
... A. A. Haidri. Requirements for the maturation of hamster oocytes in vitro. Exp Cell Res 1973. 76: ... B. D. Bavister. Vitamins and amino acids stimulate hamster blastocysts to hatch in vitro. J Exp Zool ....
BackgroundCancer development is accompanied by genetic phenomena like deletion and amplification of chromosome parts or alterations of chromatin structure. It is expected that these mechanisms have a strong effect on regional gene expression.ResultsWe investigated genome-wide gene expression in colorectal carcinoma ...
1997 Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer. Proc Natl AcadAberrant Alternative Splicing of Thyroid Hormone Receptor in a TSH-Secreting Pituitary Tumor.Q.Z.), Cold Spring Harbor, New York 11724 Patients with TSH-secreting pituitary tumors (TSHomas) have high
leukemia in Northern California. We measured DNA methylation in the promoter region of the FHIT gene in 190 of the FHIT gene, and methylation in this region correlates with loss of FHIT expression. To test whether aberrant methylation of the FHIT gene may play a role in pediatric leukemia, we ...
chromosome often plays a central role in hybrid male sterility between species, but it is unclear-wide expression data to directly associate aberrant expression patterns with hybrid male sterility between two spermatogenesis in sterile but not in fertile F1 hybrid males. Over-expression was most pronounced in ...
DNA copy number aberrations (CNAs) are genetic alterations common in cancer cells. Their transcriptional consequences are still poorly understood. Based on the fact that DNA copy number (CN) is highly correlated with the genomic position, we have applied a segmentation algorithm to gene expression (GE) to explore its relation with CN. ...
Cancer is characterized by aberrant patterns of expression of multiple genes. These major shifts in gene expression are believed to be due to not only genetic but also epigenetic changes. The epigenetic changes are communicated through chemical modifications, including histone modifications. ...
Here I present and discuss a model that, among other things, appears able to describe the dynamics of cancer cell origin from the perspective of stable and unstable gene expression profiles. In identifying such aberrant gene expression profiles as lying outside the normal stable states ...
Implantation is a complex event requiring synchronization between a developing embryo and receptive endometrium. This process is governed by molecular mechanism mediated by homeobox (Hox) genes, which encode transcription factors. These factors guide embryologic development as well as regulate differential gene expression within the ...
