Six of nine decedent beagles exposed continuously to 2.5 R*/22 hour day of whole-body 60Co gamma-radiation died with myeloproliferative diseases: three cases of myelogenous leukemia and one each of monocytic leukemia, erythroleukemia, and erythremic myelosis. The three dogs that died with myelogenous leukemia had micromegakaryocytes and megakaryoblasts in the peripheral blood during the ...

Six of nine decedent beagles exposed continuously to 2.5 R/22 hour day of whole-body /sup 60/Co ..gamma..-radiation died with myeloproliferative diseases: three cases of myelogenous leukemia and one each of monocytic leukemia, erythroleukemia, and erythremic myelosis. The three dogs that died with myelogenous leukemia had micromegakaryocytes and megakaryoblasts in the peripheral blood during the ...

Chromatic aberration is a form of aberration in color optical devices that produces undesirable color fringes along borders within images. It is becoming a more critical problem these days as digital cameras are getting smaller, while the number of picture elements is increasing. We propose a novel method for detecting and eliminating chromatic ...

A novel ultracorrector is outlined which compensates for the primary and secondary first-order chromatic aberrations and all third-order geometrical aberrations of electron optical systems with a straight axis. Owing to the imposed symmetry conditions on the fields and the paraxial fundamental rays, the corrector does not introduce ...

Some topics discussed are: maturation of megakaryocytes by polyploidy rather than by cell division; DNA replication; time period to accomplish maturation from diploid precursor; stimulation of megakaryocytopoiesis by induction of thrombocytopenia; labelin...

... Title : Megakaryocytopoiesis in Stem Cell Transplantation. ... per peripheral blood CD 34+ cell seeded. Bone marrow cells were twice as productive ...

... SYSTEM, BONE MARROW, SYNERGISM, BLOOD DISEASES, CHEMOTHERAPY, COAGULATION, BLOOD PLATELETS, ...

Some topics discussed are: maturation of megakaryocytes by polyploidy rather than by cell division; DNA replication; time period to accomplish maturation from diploid precursor; stimulation of megakaryocytopoiesis by induction of thrombocytopenia; labeling index of various maturation stages; evidence for existence of thrombopoietin; and mechanism by which thrombopoietin ...

Summary.? Background:?Transcription factors are essential for blood cell formation. Mice expressing low levels of c-Myb (c-Myb(low) ) have an increased number of bone marrow megakaryocytes (MKs) and corresponding thrombocytosis. In contrast, mice engineered to express low levels of GATA-1 (GATA-1(low) ) in the megakaryocytic lineage exhibit aberrant ...

The major findings of this study can be summarized as follows: (1) the c-myc oncogene-transfected and MTV-expressing mammary epithelial cells exhibit aberrant hyperproliferation in vitro preceding tumorigenesis in vivo; (2) upregulation of aberrant hyperproliferation (i.e., anchorage-independent growth) in initiated cells represents a ...

Bone marrow specimens from 185 patients with plasma cell disorders (PCD) were investigated by fluorescence in situ hybridization (FISH) in order to determine the temporal sequence of cytogenetic aberrations. In 25 cases combined FISH analysis has also been performed at single cell level. Clonal evolution was observed in 16% of cases. The ?13 was preceded ...

Normal murine, caprine, and human bone marrow and peripheral blood cells can be grown in diffusion chambers. The irradiated host provides a stimulus to erythrocytic and granulocytic growth over what is seen in the DC's implanted in the nonirradiated host. The stimulus is most likely humoral and affects erythropoiesis, granulopoiesis, and ...

Injection of plasma from thrombocytopenic donor rats resulted in an increase in the endomitotic index of megakaryocytes of recipient mice 32 hr after the initial treatment with plasma. The results suggested a dose-response relationship between the amount of plasma administered and the degree of stimulation of megakaryocytopoiesis. These findings demonstrate that an agent ...

The overall objective of this research proposal is to improve the capacity of stem cells to engraft the megakaryocytic lineage. Ex vivo expansion of bone marrow megakaryocyte progenitors in the presence of thrombopoietin (TPO) was significantly enhanced b...

... mg/ml DNase I. Following homogenization by passage through a 21 gauge needle, low density cells were extracted with the use of Ficoll-Paque as ...

... Addition of interleukin-3, but not stem cell factor, to ... since the frequency of CD34+ cells was greater ... of MK to treat post-transplant thrombocytopenia. ...

... marrow (BM) and peripheral blood stem cells (PBSO ... 3 (lL-3), but not stem cell factor (SOF ... MKs to treat post-transplant-associated thrombocytopenia. ...

... mg/ml DNase I. Following homogenization by passage through a 18 gauge needle, low density cells were extracted with the use of Ficoll-Paque as ...

As the result of primary re-immunization with small-pox vaccine of eight years' old children chromosome aberrations were observed in their peripheral blood lymphocytes, the frequencies being 5.3% and 7.9% on the seventh day and in a month after the reimmunization respectively. Chromosome aberrations were significantly more rare in children with a high ...

The hematopoietic microenvironment, and in particular the hematopoietic stromal cell element, are intimately involved in megakaryocyte development. The process of megakaryocytopoiesis occurs within a complex bone marrow microenvironment where adhesive interactions, chemokines, as well as cytokines play a pivotal role. Here we review the effect of stromal cells and cytokines on ...

... dynamic aberrations. For the dynamic aberration case, elimination of ... dynamic aberrations. For the dynamic aberration case, elimination of ...

The dorsal supine position for birth appears to be an aberration practised only in North America during the last 150 years and contrasting to historical precedent and current practices in most other cultures. Alternative birth positions featuring reclining, sitting, squatting or side-lying have recently been shown to have definite physiological and ...

Transverse and longitudinal phase volumes are evaluated and dilution factors defined. A new and simpler expression for the effect of third-order geometric aberrations is given. Constraints on the final quadrupole bore radius are discussed. Parameters of the example design are given and the preceding analysis is applied to it. The available dilution factor ...

Chromatic aberrations arise as a consequence of the disper- ..... Chromatic aberrations are divided into chromatic aberration ...

... superior to electrostatic systems with respect to total aberration, but their ... The two limiting aberrations, spherical and chromatic, are analyzed in this ...

... KNOWN EXPRESSIONS FOR THE ABERRATIONS OF PLANE ... CAN CONSIDERABLY REDUCE THE SPHERICAL ABERRATION AND COMA ...

In the present study, we set out to investigate cytogenetic changes in the progeny of two normal human fibroblast cell strains after exposure to sparsely or densely ionizing irradiation (X-rays or 9.8 MeV u(-1) carbon ions). The cells were regularly subcultured up to senescence. The transition to senescence was determined by measurement of population doubling numbers and senescence associated (SA) ...

Megakaryocytopoiesis is governed by a complex network of haematopoietic growth factors that regulate the different stages of the process, in which haematopoietic stem cells undergo megakaryocytic lineage commitment, proliferation, maturation, and functional activation to produce platelets. MicroRNAs (miRNA) are a class of about 22-nucleotide noncoding RNAs that have been ...

Platelets are the small anuclear blood cells that are the product of megakaryocytopoiesis, the process of hematopoietic stem cell commitment to megakaryocyte production and the differentiation and maturation of these cells for platelet release. Deregulation or disruption of megakaryocytopoiesis can result in platelet deficiencies, the thrombocytopenias, ...

During a 15-year period, 161 adult patients were diagnosed with secondary acute myeloid leukemia (s-AML) in the region of Southern Denmark. In 73 patients, the AML diagnosis was preceded by myelodysplastic syndrome (MDS-AML), in 31 patients by an antecedent hematologic disease, and in 57 patients by treatment with chemotherapy and/or irradiation (t-AML). Cytogenetic analysis ...

... CD34+ cells derived from human placental and umbilical cord blood were investigated. The cells were exposed to carbon- ... progenitor CD34+ cells derived from placental and umbilical cord blood (cord blood...

... isotype controls. Collection of Human Placental and Umbilical Cord Blood and Purification of CD34+ Cells This study was ... After informed consent was obtained from the mothers, cord blood was collecte...

The overall objective of this research proposal is to investigate several laboratory protocols to improve megakaryocyte production for future clinical use of an autologous megakaryocyte-rich product. Conditioned medium from bone marrow stromal cultures en...

Mobilized peripheral blood progenitor cell transplant, used to reconstitute hematopoiesis following high-dose chemotherapy in breast cancer patients, is associated with a requisite period of profound thrombocytopenia. To prevent or reduce the need for rep...

Following high-dose chemotherapy for the treatment of malignant disease, reinfusion of peripheral blood stem cells collected during treatment with growth factors usually results in delayed platelet engrafiment as compared to neutrophil recovery. The overa...

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The effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) on megakaryocytopoiesis and platelet production was investigated in patients with normal hematopoiesis. Three findings indicated that GM-CSF plays a role in megakaryocytopoiesis. During treatment with GM-CSF (recombinant mammalian, glycosylated; Sandoz/Schering-Plough, 5.5 micrograms ...

... surface membrane to correct for aberrations. ... less curvature results in less aberration. ... a negative conic constant helps reduce spherical aberration. ...

... for the case when piston error, tilt, defocus, spherical aberration, astigmatism or ... The effects of the aberrations on the optical wavefront, the point ...

... for chromatic aberration, astigmatism, thermal effects, and spherical aberration. An important reason for controlling aberrations through combination ...

Feb 1, 1999 ... The remaining three aberrations, spherical aberration, coma, and astigmatism, ... (Note: If there is significant spherical aberration, ...

... Right: Ratio of the RMS wavefront aberration to the original comatic RMS wavefront aberration as a function of the decenter E (full line), and the ...

... Longitudinal-chromatic and -spherical aberration, and lateral ... reducing both aberrations are discussed. ... volume hologram aberration is discussed ...

Radiation induced genomic instability has been described in a host of normal and transformed cells in vitro (Morgan 2003a). This instability can manifest as cell killing, micronuclei formation, transformation induction, di- and tri- nucleotide repeat instability, gene amplifications and mutations, and chromosomal rearrangements. Cytogenetic alterations are perhaps the best described of these ...

Although the Jak2-V617F mutation has generated strong awareness because of its causative role in myeloproliferative disorders, reports of Jak2 gene aberrations linked to hematologic malignancies have preceded those of V617F by nearly a decade. These malignant mutations include Jak2 amino acid substitutions, deletions, insertions, and chromosomal ...

The proposed electron collider lattice design with extremely low betas at the interaction Point IP (?*� 0.5cm) and the precedently large longitudinal acceptance of the collider ring (?p/p = 0.005) [1], makes the chromatic corrections of paramount importance. Here the chromatic effects of the final focus quadruples are corrected with two families of sextuples in a dispersive ...