The thallium 201/technetium 99m pertechnetate radionuclide study is becoming widely accepted as a means of localizing abnormal or aberrantly located parathyroid tissue. We describe a case in which ectopic retrosternal thyroid tissue appeared as a parathyroid adenoma on thallium-201/technetium-99m pertechnetate ...

An aberration correction method based on the maximization of the wave intensity at the focus of an emitting array is presented. The potential of this new adaptive focusing technique is investigated for ultrasonic focusing in biological tissues. The acoustic intensity is maximized non invasively through the direct measurement or indirect estimation of the ...

The repair process of damaged tissue involves the coordinated activities of several cell types in response to local and systemic signals. Following acute tissue injury, infiltrating inflammatory cells and resident stem cells orchestrate their activities to restore tissue homeostasis. However, during chronic ...

X rays have both a local and distant action on the process of cell division. The local effect appears as: a sharp fall in the number of mitoses in the first hours after irradiation; the appearance of cells with chromosomal aberration; the absence of relationship between the effect of radiation and the dimensions of the area of ...

chromosome aberrations in cells and tissues to improve understanding of the biological effects of the space radiation environment. ...

... ADRENAL GLANDS, *CELLS (BIOLOGY), *SEX GLANDS, *TISSUES (BIOLOGY), ADRENAL CORTEX, HISTOLOGICAL TECHNIQUES ...

Normal and aberrant gamma globulins were labeled by I/sup 124/ produced by alpha particle bombardment of Sb in a 60-in. cyclotron. Localization of the labeled globulin in primary brain neoplasms was demonstrated by positron scanning. It appears possible by this procedure to investigate in various tissues and organs in man ...

Adaptive focusing of ultrasonic waves is performed under the guidance of a Magnetic Resonance (MR) system. The technique is based on the maximization of the ultrasonic wave intensity at a target point. The wave intensity is indirectly estimated from the local tissue motion induced at the chosen focus by the acoustic radiation force of the ultrasonic beam. ...

A 40 � 35 � 25-mm³ specimen of human breast consisting mostly of fat and connective tissue was imaged using a 3-T magnetic resonance scanner. The resolutions in the image plane and in the orthogonal direction were 130 ?m and 150 ?m, respectively. Initial processing to prepare the data for segmentation consisted of contrast inversion, interpolation, ...

Adaptive focusing of ultrasonic waves under the guidance of a Magnetic Resonance (MR) system is demonstrated for medical applications. This technique is based on the maximization of the ultrasonic wave intensity at one targeted point in space. The wave intensity is indirectly estimated from the local tissue displacement induced at the chosen focus by the ...

... Abnormal, aberrant, or damaged proteins are also targets for destruction by the proteasome such as in cystic fibrosis. In this disease the mutated ...

A healthy ocular surface environment is essential to preserve visual function, and as such the eye has evolved a complex network of mechanisms to maintain homeostasis. Fundamental to the health of the ocular surface is the immune system, designed to respond rapidly to environmental and microbial insults, whereas maintaining tolerance to self-antigens and commensal microbes. To this end, activation ...

The ability to optimize treatments for cancer on the basis of relative risks for normal tissue injury has important implications in oncology, because higher doses of radiation might, in some diseases, improve both local control and survival. To achieve this goal, a thorough understanding of the molecular mechanisms responsible for radiation-induced ...

The epithelial cells of multicellular organisms form highly organized tissues specialized for the tasks of protection, secretion and absorption, all of which require tight regulation of the core processes of cell polarity and tissue architecture. Disruption of these core processes is a critical feature of epithelial tumors. Cell polarity and ...

A method to measure wave aberrations in the isolated crystalline lens is demonstrated. The method employs a laser scanning technique in which the trajectories of narrow refracted laser beams are measured for an array of sample positions incident on the lens. The local slope of the emerging wavefront is calculated for each sample position, and a least ...

Prostaglandins, local hormones, are produced by almost every tissue and organ in the body (except for erythrocytes). They are active at the site of their production or next to the cells that secrete them. Prostaglandins play an important biological role, because they are involved in many physiological and pathological processes. Some of their effects are ...

Previous studies showed that intercellular communication by gap junctions has a role in bone formation. The main connexin involved in the development, differentiation, and regulation of bone tissue is connexin (Cx) 43. In addition, Cx46 is also expressed, mostly localized within the trans-Golgi region. Alterations in the expression pattern and ...

... Abstract : Our group previously showed that FOXO proteins are aberrantly localized to the cytoplasm in cells that have sustained loss of functional ...

... centrosome. Consistent with its localization around the centrosomes PSMA expressing cells rapidly exited mitosis. We ...

aberrations. Spherical, adjustable Rc: Permits first-order correction to match local figure of parabola; allows subaperature placement ...

... to query the DoD laboratory community or ... AS WE HAVE BUILT IS USEFUL ... EFFICIENCY, LOCALIZED OPTICAL CORRECTION OF WAVEFRONT ...

Deep hypothermic circulatory arrest is necessary for some types of cardiac and aortic surgery. Perfusion of the brain can be maintained using a heart-lung machine and unilateral antegrade cerebral perfusion. Cooling rates during extracorporeal circulation depend on local perfusion. A core temperature of 24 degrees C-25 degrees C is aimed at to extend ischemic tolerance of ...

In humans, aromatase (CYP19) gene expression is regulated via alternative promoters. Activation of each promoter gives rise to a CYP19 mRNA species with a unique 5'-untranslated region. Inhibition of aromatase has been reported to downregulate lung tumor growth. The genetic basis for CYP19 gene expression and aromatase activity in lung cancer remains poorly understood. We analyzed ...

The invention is directed to a method of diagnosing a cell proliferative disorder of breast tissue by determining the methylation status of nucleic acids obtained from a subject. Aberrant methylation of several genes including TWIST, HOXA5, NES-1, retinoi...

Dermatofibrosarcoma protuberans (DFSP) is a soft tissue tumor with tendency to recur locally and only rarely metastasizes to vital organs. Surgery with wide margins remains the standard treatment. DFSP is characterized by specific chromosomal abnormalities involving the platelet derived growth factor B locus (PDGFB). In the majority of cases a ...