Recoverin is cotranslationally modified by the covalent linkage of a myristoyl group to its N terminus. It is a member of a family of Ca(2+)-myristoyl switch proteins. Recombinant myristoylated revoverin is currently produced by the cotransformation of bacteria with recoverin and an enzyme that allows N-myristoylation and by supplementing the culture ...
PubMed
Among retina-specific proteins, recoverin is unique with respect to its cellular regulation in that it is found in rods, cones, some bipolar cells, and a rare population of cells in the ganglion cell layer. Recoverin is a calcium-binding protein which inhibits rhodopsin kinase from phosphorylating rhodopsin. Because cells in the inner layers of the retina ...
... KNOWN EXPRESSIONS FOR THE ABERRATIONS OF PLANE ... CAN CONSIDERABLY REDUCE THE SPHERICAL ABERRATION AND COMA ...
DTIC Science & Technology
The Ca2+-binding protein recoverin is thought to regulate rhodopsin kinase and to modulate the lifetime of the photoexcited state of rhodopsin (Rh*), the visual pigment of vertebrate rods. Recoverin has been postulated to inhibit the kinase in darkness, when Ca2+ is high, and to be released from the disk ...
PubMed Central
Recoverin is a calcium binding protein abundantly and specifically expressed in photoreceptors. There are four EF hand Ca2+ binding domains but only two, the second and third, are thought to be functional. We have analyzed the structural gene for recoverin in patients with autosomal dominant retinitis pigmentosa and Leber`s congenital ...
Energy Citations Database
PurposeCancer-associated retinopathy is a paraneoplastic retinal degeneration which may primarily result from auto-immune mediated apoptosis. It has been hypothesized that high titer of auto-antibodies are able to cross the blood-retinal barrier (BRB) and to enter retinal cells to activate apoptotic pathway which has been already well-established. However, it still remains to be elucidated whether ...
... EACH SHAPED FOR MINIMUM SPHERICAL ABERRATION. THESE EXPRESSIONS INCLUDE THE PRIMARY ABERRATIONS AND THE ...
This paper introduces the concept of the central principal ray of a spherical surface. An expression is obtained that determines the spherical aberration of the surface at this ray. A relationship is demonstrated between the monochromatic aberrations of a spherical surface.
A novel calcium-binding protein (molecular weight 23,000-24,000, pI 5.3-5.5), which we term neurocalcin, was identified in bovine brain. Using calcium-dependent drug affinity chromatography ((S)-P-(2-aminoethyloxy)-N-[2-(4-benzyloxycarbonylpiperazinyl++ +)-1-(P- methoxybenzyl)ethyl]-N-methylbenzene-sulfonamide dihydrochloride, W-77, -coupled Sepharose 6B), we purified neurocalcin from bovine ...
/c mice are similar, the immunogenicity of R49.2 and R64 peptides were examined in BALB/c mice that R64 is an immunogenic peptide in human and BALB/c mice. To test whether endogenously expressing Rec recombinant Rec (Fig. 6B). R49.2 peptide and PBS were not immunogenic (Fig. 6). No histological changes
E-print Network
In this paper we derived expressions for the beams envelopes for a large class of initial phase contours both in the paraxial approximation and with allowance for certain types of aberrations. (AIP)
It has been postulated that myristoylation of peripheral proteins would facilitate their binding to membranes. However, the exact involvement of this lipid modification in membrane binding is still a matter of debate. Proteins containing a Ca2+-myristoyl switch where the extrusion of their myristoyl group is dependent on calcium binding is best illustrated by the ...
Aberrations of optical systems are usually analyzed by decomposing the wavefront aberration at a pupil into a series of terms. The Seidel and Zernike series are two common examples, each with its own strengths and weaknesses. A new aberration series is proposed that combines some of the strengths of each. The new series is consistent ...
Misalignment-induced wave aberrations up to the fifth order inclusive are investigated within the framework of the Seidel eikonal theory in the approximation of the first order of misalignment shifts of optical components. An expression for the angular characteristic (angular eikonal) of a one-parameter aspherical optical surface is derived. The ...
A definition of a wave aberration as a phase shift upon composition of light waves in the image of a point is given using the concept of point eikonal. An expression that determines the total differential of a wave aberration function is obtained and the condition of its integrability is determined. The sequence of the wave ...
NASA Astrophysics Data System (ADS)
Asymptotic expressions are derived for the two-dimensional incoherent optical transfer function (OTF) of an optical system with defocus and spherical aberration. The two-dimensional stationary phase method is used to evaluate the aberrated OTF at large and moderately large defocus and spherical aberration. For ...
We hypothesized that aberrant expression of Hox genes in mammary epithelial cells results in the inappropriate regulation of a wide variety of Hox target genes; this could lead to a change from a normal to a preneoplastic, or from a preneoplastic to a neo...
National Technical Information Service (NTIS)
... centrosome. Consistent with its localization around the centrosomes PSMA expressing cells rapidly exited mitosis. We ...
... Abnormal, aberrant, or damaged proteins are also targets for destruction by the proteasome such as in cystic fibrosis. In this disease the mutated ...
... BIOSYNTHESIS, GROWTH(PHYSIOLOGY), EVOLUTION(BIOLOGY), PERIPHERAL NEUROPATHY, RIBOSOMES, SUPPRESSORS ...
... CANCER, EPITHELIUM, NEOPLASMS, VECTOR ANALYSIS, GENES, CELLS(BIOLOGY), LESIONS, TETRACYCLINES, PITUITARY HORMONES. ...
... FIBROSIS, *NEUROBIOLOGY, MUTATIONS, MOLECULAR BIOLOGY, GENES, CELLS(BIOLOGY), PERIPHERAL NEUROPATHY, ONCOGENESIS ...
... The loss of TACI expression in prostate cells therefore conceivably results in an imbalance in homeostasis resulting in the aberrant accumulation of ...
Approximate expressions of the ray aberrations for off-axis collimated beams and free form phase plates with a small derivative magnitude are derived with the defocus aberration taken into account. The cubic phase plate, which is one of the most commonly used phase plates in wavefront coding imaging systems, is illustrated as an ...
An expression for the phase error in the aperture plane of a spherical reflector was developed. The nature of this phase error over the aperture plane is discussed, and, to illustrate the usage of the expression, examples are given.
... expression in prostate tumor cells was quite different than in other cell types, and prostate Ets family expression relative to other tissues was ...
Previous studies have demonstrated that a small population of cancer stem cell-like cells exists in retinoblastoma. To provide a model for studying this population, we sought to establish a long-term culture from human retinoblastoma that have cancer stem cell-like properties. Fresh tumor tissue was digested and cultured in serum-free medium. Tumor spheres formed and were passaged continuously. ...
We present, analyze, and evaluate expressions for the wavefront aberrations in an off-axis spherical mirror. These formulas are derived from the optical path difference between an ellipsoid and a sphere, assuming a relatively small pupil and a small angle of incidence, as will be described in detail. Some well-known and also some useful new ...
For a diverging electron beam with parabolic space-charge density distribution, first-order perturbation theory is used to derive an analytic expression, yielding the aberrations as a function of the covered distance. Application of the derived expression shows that the performance of electrostatic projection TV guns may be severely ...
BackgroundThe Ca2+-binding protein recoverin operates as a Ca2+-sensor in vertebrate photoreceptor cells. It undergoes a so-called Ca2+-myristoyl switch when cytoplasmic Ca2+-concentrations fluctuate in the cell. Its covalently attached myristoyl-group is exposed at high ...
PurposeThe aim of this study is to investigate the synergistic effect of chondroitinase ABC and growth factors in the integration of murine retinal progenitor cells (mRPCs) transplanted into Rho?/? mice.MethodsmRPCs from P1 green fluorescent protein-transgenic mice were isolated and expanded for transplantation. All mRPCs of 20 passages or less were transplanted into the ...
Polymerase chain reaction was used to search for genes encoding recoverin-like proteins in Drosophila melanogaster. We identified a gene that codes for a cognate of bovine neurocalcin; hence, we have named it neurocalcin (nca). A cDNA of nca was isolated and sequenced. The deduced polypeptide product of the cDNA is 22 kDa in size, and its amino acid sequence is 88% identical ...
The present invention relates to methods and compositions concerning resistance to a drug for cancer comprising aberrant KIT signal, such as aberrant KIT sequence or expression. In a specific embodiment, the cancer is also initially responsive to imatinib...
Explicit integral expressions are given for the fifth-order geometrical aberration coefficients in rectilinear magnetic quadrupole-octupole systems used for the transport of nonrelativistic charged particle beams. The numerical values of the fifth-order g...
The research reveals that there are higher-order aberrations in visual optical systems, and the important factors are higher-order aberrations that affect the quality of vision to further improve. To correct the higher-order aberrations, the aberrations of vision system must be effectively measured and analyzed. It ...
Recoverin, a new member of the EF-hand superfamily, plays a critical role in the light/dark adaptation of retinal rods by regulating rhodopsin phosphorylation in a Ca(2+)-dependent manner. Recoverin is composed of four isoforms, each of which is modified at its N terminus by myristate (C14:0) or its structurally related fatty acid (C12:0, C14:2, or C14:1). ...
We developed an expression that describes the hollow Gaussian beams (HGBs) passing through a spherically aberrated lens by using the Collins formula. The radial intensity distribution in both spherical aberration SA free lens, lens that exhibits relatively large in both positive spherical aberration PSA, and ...
Explicit integral expressions are given for the fifth-order geometrical aberration coefficients in rectilinear magnetic quadrupole-octupole systems used for the transport of nonrelativistic charged particle beams. The numerical values of the fifth-order geometrical aberration coefficients for a rare earth cobalt (REC) quadrupole ...
The expression of protein kinases genes if often altered in tumors. The aberrant expression of several of these genes typically parallels the progression toward a more malignant phenotype. We developed a cDNA micro-array- based screening system to mearuse...
The expression of genes involved in signal transduction (e.g. protein kinases) is often altered in tumors. The aberrant expression of several of these genes typically parallels the progression toward a more malignant phenotype. We developed a cDNA micro-a...
In clinical ophthalmology, the wavefront aberration of human eyes is expressed by Zernike polynomial after cataract surgery and intraocular lens implantation, the human eyes aberration will change. The problem of objective evaluation of wavefront aberration introduced by the Intra-ocular (IOL) in-vivo remains ...
Due to the retina�s inability to replace photoreceptors lost during retinal degeneration, significant interest has been placed in methods to implant replacement cells. Polymer scaffolds are increasingly being studied as vehicles for cellular delivery to degenerated retinas. Previously, we fabricated poly(methyl methacrylate) thin film scaffolds that increased survival and integration of ...
.elsevier.com/locate/lungcan Chromosomal aberrations and gene expression profiles in non-small cell lung cancer E. Dehana , A. Ben-Dorb , W 2006 KEYWORDS Non-small cell lung cancer; Chromosomal aberrations; Expression profiling; Expression results provide a high resolution map of copy number ...
protein apelin; peptide ligand for APJ receptor recoverin glycine cleavage system protein H (aminomethyl
... Thus, loss of CEACAMI tumor suppressor gene expression in prostate cancer is due to aberrant chromatin acetylation. ...
Exploit the aberrant expression of glycan structures that occurs during oncogenesis in order to gain an understanding of cancer progression with translational applications for diagnosis, prognosis, and response to therapy.
Cancer.gov
... an important role during development and that its aberrant re-expression by adult NF 1 cells contributes to the development of Schwann cell tumors ...
T cell Subtypes MIP #8 Libin Zhang Altered expression of CUG-BP in myotonic dystrophy leads to aberrant m
... to demonstrate that BCSG1 expression in breast cancer cells directly inhibits the mitotic checkpoint function and induces aneuploidy in a BubRI ...
... association between SNCG protein expression in primary ... sequencing and methylation-specific PCR assays, we ... CpG island of SNCG gene in every ...
... to demonstrate that BCSG1 expression in breast cancer cells directly inhibits the mitotic checkpoint function and induces aneuploidy in a BubR1 ...
... We reasoned that aberrant 4.1 expression could engender defects in functions of centrosomes, mitotic spindles and in cytokinesis. ...
... NERVE CELLS, GENES, FIBROBLASTS, CELLS(BIOLOGY), SKIN(ANATOMY), FIBROSIS, PERIPHERAL NEUROPATHY, ONCOGENESIS. ...
A method aimed to minimize the impact of spectral aberrations in a monochromator is proposed in which the spectrum of the source of radiation under study is scanned by the rectilinear translation of a plane chirped grating. The chirped grating, which has a spatially variable groove spacing, is used to diffract and to spectrally focus the radiation. Imaging properties of the ...
Adaptive optics systems typically include an optical relay that simultaneously images the science field to be corrected and also a set of pupil planes conjugate to the deformable mirror of the system. Often, in the optical spaces where DM's are placed, the pupils are aberrated, leading to a displacement and/or distortion of the pupil that varies according to field ...
The paper presents expressions describing the time-of-flight of charged particles in the emission system, taking into account the time-of-flight chromatic aberrations up to the fifth-order of the infinitesimal. The spatial time-of-flight characteristics of the axially symmetric emission system consisting of two equal-sized coaxial cylinders and a plane ...
A matrix method to do nonlinear calculations is described. This is possible only under the special condition when a transformation maps a zero vector onto a zero vector. Geometrical optics conform to this condition and hence matrix methods can be applied to calculate aberrations. Methods to reduce computational complexities using symmetry arguments are provided. The formalism ...
Endometrial cancer is the most commonly diagnosed gynecological cancer, and it has been shown to be a complex disease driven by abnormal genetic, and epigenetic alterations, as well as environmental factors. Epigenetic changes resulting in aberrant gene expression are dynamic and modifiable features of many cancer types. A significant epigenetic change is ...
This paper is an attempt to provide new insight into the behavior of near-field scalar diffraction phenomena by showing that the Rayleigh-Sommerfeld diffraction integral is equivalent to the Fourier transform integral of a generalized pupil function which includes a term that represents phase errors in the aperture. This term can be interpreted as describing a conventional wavefront ...
AbstractThe maspin gene functions as a tumor suppressor in human breasts, and its expression is frequently lost during breast cancer progression. In vitro models of human breast cancer indicate that the loss of maspin expression is closely linked to aberrant methylation of the maspin promoter. We conducted a study on 30 archival ductal ...
Marmoset photoreceptor development was studied to determine the expression sequence for synaptic, opsin, and phototransduction proteins. All markers appear first in cones within the incipient foveal center or in rods at the foveal edge. Recoverin appears in cones across 70% of the retina at fetal day (Fd) 88, indicating that it is ...
The relationship of aberrant DNA hypermethylation of cell cycle checkpoint genes with the sensitivity of cancer cells to anticancer drugs is a question of current interest. In this study, we investigated the relationship between aberrant hypermethylation of the CHFR (checkpoint with forkhead-associated and ring finger) mitotic checkpoint gene and ...
A simple geometrical method to measure the aberration of astigmatism present in the wavefront that emerges from a telescope is presented. The method is based on the analysis of the external contour of the image of a slightly defocused star. An expression elliptical edge is obtained, which links the rms value of Z22 to the geometric parameters of the ...
We report directed differentiaion of retinal precursors in vitro from mouse ES cells. Six3+ rostral brain progenitors are generated by culturing ES cells under serum-free suspension conditions (SFEB culture) in the presence of Wnt and Nodal antagonists (Dkk1 and LeftyA), and subsequently steered to differentiate into Rx+ cells (16%) by treatment with activin and serum. Consistent with the ...
We report directed differentiaion of retinal precursors in vitro from mouse ES cells. Six3+ rostral brain progenitors are generated by culturing ES cells under serum-free suspension conditions (SFEB culture) in the presence of Wnt and Nodal antagonists (Dkk1 and LeftyA), and subsequently steered to differentiate into Rx+ cells (16%) by treatment with ...
In the present paper, the paraxial lateral aberrations of second and third orders in imaging electron optical systems, in which the aberration coefficients are solved by asymptotic solutions of paraxial equation, have been verified and tested by a two-electrode electrostatic spherical concentric system model. The analytical expressions ...
Wave aberrations degrade the optical quality of the eye relative to the diffraction limit, but there are situations in which having slightly aberrated optics can provide some relative visual benefits. This fact led us to consider whether interactions among aberrations in the eye's wavefront produce an advantage for image quality ...
