The rejoining distance for the formation of dicentric chromosomes in human lymphocytes was derived on the basis of microdosimetric concepts. For the formation of a dicentric chromosome, primary lesions produced by absorption events can interact within the nucleus over a distance of at least 1 mu m. The dispersion of ...

An unusual spectrum of aberrations, characterized by a sharp exchange deficiency, was demonstrated in germinating seeds of Crepis capillaris L. synchronized with 2'-deoxy-5-fluorouridine at the start of the S phase following exposure to 100 R x-rays. The modification of the cytogenetic effect of x-radiation of dry crepis seeds (10 and 15 kR) by 5-aminouracil consisted ...

A quantitative analysis is made of the molecular mechanism of formation of dicentrics, and the dose function is calculated. There is discussion of the case of irradiation in low doses, when the yield of dicentrics is a linear function of dosage of ..gamma..-radiation. Some experimental data are submitted in support of formation of radiation-induced ...

... For example, disc tilt dependence may require coma compensation, whereas double layer formats require spherical aberration compensation. ...

... in a group of nine radiologists are presented. Chromosome aberrations were detected by fluorescence plus Giemsa staining and ... consider the underlying mechanisms of aberration formation. A chromosome ab...

Recent work on the roles of specific kinds of DNA lesions and their enzymatic repair systems in the production of chromosomal aberrations seems consistent with a simple molecular model of chromosomal aberrations formation. Evidence from experiments with t...

In an electron beam device in which an electron beam is developed and then focused by a lens to a particular spot, there is provided a means for eliminating spherical aberration. A sextupole electromagnetic lens is positioned between two focusing lenses. The interaction of the sextupole with the beam compensates for spherical ...

In eukaryotic cells, the faithful segregation of daughter chromosomes during cell division depends on formation of a microtubule (MT)-based bipolar spindle apparatus. The Nuclear Mitotic Apparatus protein (NuMA) is recruited from interphase nuclei to spindle MTs during mitosis. The carboxy terminal domain of NuMA binds MTs, allowing a NuMA dimer to function as a �divalent� ...

The base analog cytosine arabinoside (CA) is an inhibitor of DNA synthesis that is able to induce chromosomal aberrations not only in the DNA synthetic (S) phase of the cell cycle but in cells in the pre- (G/sub 0/ or G/sub 1/) and in the post-DNA-synthetic (G/sub 2/) phases of the cell cycle as well. Incubation of human peripheral lymphocytes in CA following either G/sub 0/ ...

A biophysical model for the kinetics of the formation of radiation-induced chromosome aberrations is