Immunofluorescent microscopy was used to study, in non-muscle cells, the intracellular distribution of calmodulin, an important regulator of Ca-dependent cellular processes, and to show whether calmodulin is associated with the fiber systems of cells. A c...
National Technical Information Service (NTIS)
... forms during carcinogenesis. All contained p53 and an endogenous alternatively spliced form, p53as. p53/p53as mutation ...
DTIC Science & Technology
... The DNA binding sequence of the endogenous active form of mouse p53, p53as, has been shown to contain the same hallmarks as that for p53. ...
The human epidermal growth factor receptor (EGFR) promoter is activated by both wild-type and tumor-derived mutant p53. In this report we demonstrate that the EGFR promoter is activated by tumor-derived p53 mutants p53-143A, ...
We have previously reported that the human p53 gene encodes at least nine different p53 isoforms, including ?133p53?, which can modulate p53 transcriptional activity and apoptosis. In this study, we aimed to investigate the ...
PubMed Central
... impact of the chosen p53 mutations, 6. Diploid cells are selected ... M et al.: p53 mutations and survival in stage I non small- cell lung cancer: results of ...
Approximately 50% of human cancers have accumulated missense mutations in the gatekeeping tumor suppressor protein p53, usually resulting in genomic instability and a very poor prognosis. The wild-type p53 protein is required for assessing DNA damage in c...
The protein p53 is an important tumor suppressor. Under normal conditions, cells do not contain high levels of this protein. If a healthy cell is damaged, p53 is expressed and its cellular level increases, followed by inhibition of cell growth or programm...
... p53-null MEFs. In a genome wide p53 ChIP analysis of human colon cancer cell lines, Chen et al. detected p53 binding ...
p53 is a well-known tumor suppressor and is also involved in processes of organismal aging and developmental control. A recent exciting development in the p53 field is the discovery of various p53 isoforms. One p53 isoform is human ...
PubMed
... a combined germline NFl/p53 mutant model that develops MPNSTs; and a combined NFl/p53 mutant model that develops astrocytomas. ...
... TITLE: The role of ATF3, a new p53 regulator, in prostate carcinogenesis PRINCIPAL INVESTIGATOR: Chunhong Yan, Ph.D. ...
... Accession Number : ADB245442. Title : Ribozyme-Mediated Repair of Mutant p53 Transcripts in Breast Cancer Cells. Descriptive Note : Annual rept ...
... Accession Number : ADA387872. Title : Ribozyme-Mediated Repair of Mutant p53 Transcripts in Breast Cancer Cells. Descriptive Note : Final rept. ...
... Ribozyme-Mediated Repair of Mutant P53 Transcripts in Breast Cancer Cells ... Figure 4: Ribozyme expression cassette design and evaluation ...
... Accession Number : ADB256780. Title : Ribozyme-Mediated Repair of Mutant P53 Transcripts in Breast Cancer Cells. Descriptive ...
... 1999. One mechanism for cell type-specific regulation of the bax promoter by the tumor suppressor p53 is dictated by the p53 response element. ...
... HMEC) that retain wild type p53 function, and to determine if these cells may be ... repression, although all other tested p53 functions are retained ...
... Title : P53 Regulation of Uridine Phosphorylase Activity, Pyrimidine Salvage Pathway and Their Effects on Breast Cancer Therapy. ...
... Title : P53 Regulation of Uridine Phosphorylase Activity Pyrimidine Salvage Pathway and Their Effects on Breast Cancer Therapy. ...
... TITLE: p19 ARF-p53 Tumor Suppressor Pathway During Oncogene- Induced Apoptosis and Senescence ... Apoptosis and Senescence ...
... including suggestions for reducing this burden to ... Tumor suppressor p53, transcriptional regulation, cell ... to OM treatment with reduced growth rates ...
... Accession Number : ADA431331. Title : Negative Regulation of Tumor Suppressor p53 Transcription in Breast Cancer Cells. ...
... Accession Number : ADA419534. Title : Negative Regulation of Tumor Suppressor p53 Transcription in Breast Cancer Cells. ...
... Accession Number : ADA395575. Title : Negative Regulation of Tumor Suppressor p53 Transcription in Breast Cancer Cells. ...
... library of putative p53-binding DNA fragments was transformed into an auxotrophic histidine-defi- cient yeast strain with a galactose-inducible yeast ...
... stresses. It has been predicted that there are over 1500 consensus p53 binding sites present in the human genome. However ...
... stresses. It has been predicted that there are hundreds of consensus p53 binding sites present in the human genome. To ...
... TITLE: Identification of Pro-differentiation p53 Target Genes and E valuation of Expression in Normal and Malignant Mammary Gland ...
... NDIA - National Defense Industrial Association Conference Proceedings. ... Descriptive Note : Annual rept. ... mutants p53(DELTA 92-109), p53(DELTA ...
... cells. In this study, we are analyzing p53 binding to DNA fragments containing insertion/deletion mismatches (IDLs). p53 ...
... Title : Bifunctional Alkylating Agent-Induced p53 and Nonclassical Nuclear Factor kB Responses and Cell Death are Altered by Caffeic Acid ...
Research article Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53
E-print Network
... A Novel Knock-out Animal Model to Analyze ... the conventional p53 knockout (p53-/-) mouse ... Moreover, unlike conventional knockouts, our model ...
