A guided biopsy technique has been developed for evaluation of solitary bone abnormalities, identified by gallium 67 or technetium 99 bone scans, in patients with normal or ambiguous x-ray findings. Continuous gamma camera monitoring is used to guide staining of the bone ...

Share Cleidocranial dysostosis is a disorder involving the abnormal development of bones in the skull and collar (clavicle) area. The condition is passed down through families...

Sections Children's Health Issues Chapters Hereditary Connective Tissue Disorders Osteochondrodysplasias Osteochondrodysplasias are a group of rare disorders of bone or cartilage that cause the skeleton to develop abnormally. In osteochondrodysplasias, ...

It is suggested that the former division of degenerative arthritis into idiopathic types and those secondary to some disease process is no longer valid. Recent studies have indicated that abnormal concentrations of force on cartilage lead to the development of this disease. A classification is presented that is based on the assumption that the process is ...

Fibrous dysplasia (FD) of bone is one of the most frequently encountered anomalies of skeletal development. It may involve one or more bones and, particularly when polyostotic, is sometimes associated with abnormal skin pigmentation and endocrine abnormalities. FD occurs mainly in large limb ...

Thyroid hormones are critical determinants of postnatal skeletal development. Thyroid hormone deficiency or excess in children results in severe abnormalities of linear growth and bone maturation. These clinical observations have been recapitulated in mutant mice and these models have facilitated studies of the mechanisms of thyroid ...

Liver, intestinal, and bone alkaline phosphatase isoenzymes were measured using heat stability and L-phenylalanine inhibition techniques in 78 patients on intermittent haemodialysis. Fifty-five patients had abnormalities in one or more of the isoenzymes. Changes in bone and intestinal alkaline phosphatase activities seemed to be ...

... follows: 1. Group A showing osteoporosis. 2 ... osteomyelitis). The most common bone abnormality was that of osteoporosis. This ...

This article presents the development of an in vivo, three-dimensional methodology using markerless bone registration for examining the normal and abnormal kinematics of the wrist carpal bones. The resulting descriptions of three-dimensional kinematics from healthy patients and patients with documented unilateral ...

The book is divided into seven major sections on Decrease in bone density, Osteosclerosis, Localized lesions in bone, Lesions affecting the epiphyses, Abnormalities in the region of the metaphysis, Periosteal reactions, and Abnormalities in size and modelling of bone.

Bone development is dependent on the functionality of three essential cell types: chondrocytes, osteoclasts and osteoblasts. If any of these cell types is dysfunctional, a developmental bone phenotype can result. The bone disease osteopetrosis is caused by osteoclast dysfunction or impaired osteoclastogenesis, ...

A gamma scanning method was developed for assessing the rate of bone graft healing with the recently developed bone-seeking radiopharmaceuticals /sup 99m/Tc-polyphosphate and /sup 99m/Tc-diphosphonate. These were utilized to evaluate graft materials placed in surgically created 2-cm defects in the ulnae of ...

Cathepsin K, a papain-like cysteine protease, is highly expressed in osteoclasts and plays a critical role in bone resorption. Dysfunction of the enzyme leads to various skeletal abnormalities. The recent knowledge that the collagenolytic activity of cathepsin K depends on interactions with bone and cartilage-resident ...

Seventy-five female patients with early primary cancer of the breast were studied by bone scanning with /sup 99//super m/Tc labeled phosphate at the time of initial presentation and serially during follow-up examination. Eleven patients had an abnormal bone scan at the time of presentation. During follow-up periods, which have ranged ...

During investigations on the carcinogenic effects of alpha and BETA - emitting radionuclides, serial radiographs of rats injected with single and repeated doses of P/sup 32/, Pu/sup 239/ or Am/sup 241/ were studied to record the development of radioinduced changes. Among the lesions observed were failure of longitudinal bone growth, ...

Fifteen patients developed acute nonlymphocytic leukemia (ANLL) 31 to 182 months following chemotherapy and/or radiotherapy for various malignancies and one non-neoplastic disorder. The ANLL was commonly heralded by a brief preleukemic phase consisting of cytopenias and a variety of morphologic abnormalities. At diagnosis of ANLL, all of the patients had a ...

... of the patient in preventing the development of septic ... This abnormality occurs ... studies concerning the mechanisms by which abnormalities of the ...

Mice possessing no Has2 expression in chondrocytes died near birth and displayed abnormalities throughout their skeleton. By embryonic day 18.5, the long bones were short and wide, and possessed excessive mineralization within their diaphysis, with little evidence of diaphyseal bone modeling. However, this does not appear to be ...

Recent reports describe hematopoietic abnormalities in mice with targeted instability of the mitochondrial genome. However, these abnormalities have not been fully described. We demonstrate that mutant animals develop an age-dependent, macrocytic anemia with abnormal erythroid maturation and megaloblastic changes, ...

Recent reports describe hematopoietic abnormalities in mice with targeted instability of the mitochondrial genome. However, these abnormalities have not been fully described. We demonstrate that mutant animals develop an age-dependent, macrocytic anemia with abnormal erythroid maturation and megaloblastic changes, ...

The myelodysplastic syndromes represent a preleukaemic state in which a clonal abnormality of haemopoietic stem cell is characterised by a variety of phenotypic manifestations with varying degrees of ineffective haemopoiesis. This state probably develops as a sequence of events in which the earliest stages may be difficult to detect by conventional ...

... development of facial bones to self-destruct (undergo apoptosis). This abnormal cell death may lead to the ... glossary definitions help with understanding Treacher Collins syndrome? apoptosis ; autosomal ; autosomal dominant ; cell ; cleft palate ; coloboma ; dysplasia ; ...

The objective of this study is to correlate the presence of bone and liver metastases in patients with breast cancer with respect to the results of bone and liver scans, axillary nodal status, and serum alkaline phosphatase levels. One hundred ninety-seven patients with breast cancer treated by modified radical mastectomy between the years 1978 and 1981 ...

Skeletal limb abnormalities refer to a variety of bone structure problems in the arms or legs (limbs). ... Skeletal limb abnormalities are most often used to describe defects in the legs or arms that are associated with your genes ...

Paget�s disease of bone (PDB) is a progressive monostotic or polyostotic metabolic bone disease characterized by focal abnormal bone remodeling, with increased bone resorption and excessive, disorganized, new bone formation. PDB rarely occurs before middle age, and it is ...

Three spontaneously aborted fetuses with Type I achondrogenesis in a family with a first cousin marriage are described. Studies by light microscopy revealed abnormal cartilage, enchondral, and periosteal bone, and normal tooth development with abnormal alveolar bone. Electron microscopic ...

GS is an uncommon autosomal recessive disorder characterized by pigmentary dilution of the skin and hair and in most patients by abnormal regulation of the immune system. Childhood melanoma is rare in the pediatric population. The best prognosis is achieved with early diagnosis and definitive surgical excision of melanoma. We report a case of a patient with GS type II and ...

... of anemia that don�t respond to treatment (refractory), myelodysplastic syndrome associated with chromosome abnormality, and unclassified ...

an older person What Abnormal Results Mean Lumbosacral spine x-rays may show: Abnormal curves of the spine Abnormal wear on the cartilage and bones of the lower spine, such as bone...

Bone abnormalities have repeatedly been reported in animals experimentally depleted of Mg and, less frequently, in conditions associated with hypermagnesemia. Effects of Mg depletion include reduced bone growth and maturation, brittleness and reduced breaking strength, increased bone density, and morphologic ...

Osteoporosis and fractures occur frequently in patients with beta-thalassemias, a group of congenital hemolytic anemias characterized by decreased synthesis of the beta chain of hemoglobin. In this study, we determined the bone abnormalities of the th3 thalassemia mouse, generated by deletion of the mouse beta-chain genes. The heterozygous th3/+ mouse has ...

Osteoporosis and fractures occur frequently in patients with beta thalassemias, a group of congenital hemolytic anemias characterized by decreased synthesis of the beta chain of hemoglobin. In this study, we determined the bone abnormalities of the th3 thalassemia mouse, generated by deletion of the mouse beta chain genes. The heterozygote th3/+ mouse has ...

... a brief outline for the development and implementation of ... data exceptions with the abnormalities will be ... the attributes of the abnormality and search ...

Lysophosphatidic acid (LPA) is a lipid mediator that acts in paracrine systems via interaction with a subset of G protein-coupled receptors (GPCRs). LPA promotes cell growth and differentiation, and has been shown to be implicated in a variety of developmental and pathophysiological processes. At least 6 LPA GPCRs have been identified to date: LPA(1)-LPA(6). Several studies have suggested that ...

One source of genomic instability in tumours is abnormal mitotic segregation of chromosomes. Evaluation of chromosome segregation and cytogenetic aberrations in 28 bone and soft tissue neoplasms revealed few mitotic disturbances in benign lesions, whereas most of the malignant tumours, except for chondrosarcomas, showed anaphase bridges and/or multipolar ...

Lesions due to abnormal modelling of trabecular bone were identified in the femurs of 26 of 55 prenatal and neonatal calves at postmortem examination. Abnormalities included growth retardation lines and lattices, focal retention of primary spongiosa and persistence of secondary spongiosa. The possible cause and pathogenesis of these ...

Chronic kidney disease-mineral and bone disorder (CKD-MBD) is considered to be a systemic disorder that associated with fracture, cardiovascular disease, and mortality. Because the early initiation of appropriate therapy may prevent or ameliorate the mineral and bone disorder that developed in late CKD, the ability to define the ...

This review of the peer-reviewed literature focuses on the effects of spaceflight on bone. Studies performed in humans and laboratory animals have revealed abnormalities in bone and mineral metabolism that suggest that long-duration spaceflight will have detrimental effects on the skeleton. However, because of large gaps in our ...

Interventions directed to the recognition of abnormal bone mineral density, bone mineral content, and body composition in the pediatric age require the definition of factors influencing bone mass acquisition during growth. We have evaluated in a cross-sectional manner by dual-energy X-ray absorptiometry the impact ...

Paget's disease is a chronic disorder of bone remodeling, characterized by an abnormal increase of osteoclast and, hence, osteoblast activity. The imbalance of bone turnover results in the formation of unhealthy and fragile bone. It also leads to impairment of adjacent joints and to a risk of various complications. ...

The radionuclide investigation of skeletal trauma in the past was confined generally to scintimetry and an occasional bone scan. The development of improved radiopharmaceuticals, including /sup 99m/Tc-labeled compounds with their enhanced sensitivity, and the refinement of imaging devices offering superior resolution and speed have allowed a more ...

Osteochondrodysplasias are caused by abnormal development and growth of cartilage and bone. These abnormalities have been reported in both humans and animals with dwarfism. The basset hound is considered a breed with a disproportionate prevalence of dwarfism, the cause of which is unknown. To determine the type of ...

Currently infection with the human immunodeficiency virus-1 (HIV-1) is in most instances a chronic disease that can be controlled by effective antiretroviral therapy (ART). However, chronic use of ART has been associated with a number of toxicities; including significant reductions in bone mineral density (BMD) and disorders of the fat metabolism. The peroxisome ...

The results of human cytogenetic studies performed at the National Institute of Radiological Sciences (NIRS), Chiba, Japan for about 25 years are described. The studies were pursued primarily under two major projects: one involving people exposed to radiation under various conditions and the other involving patients with malignant diseases, especially leukemias. Whereas chromosome ...

The cytogenetic findings in 11 patients with multiple myeloma in whom a myelodysplastic syndrome or an acute nonlymphocytic leukemia developed are reported. All patients were treated with oral melphalan for 2-9 years in a total dose of 0.5-4.1 g. When examined during the myelodysplastic or leukemic phase, all patients had an abnormal ...

We present the first report of the development of characteristic radiologic appearances of long bones during the first year of life in an infant with type V osteogenesis imperfecta (OI). We show the evolution of metaphyseal abnormalities from a rickets-like appearance to the classically described dense metaphyseal bands. These ...

... Descriptors : *HISTOPATHOLOGY, *BONE FRACTURES, EXPERIMENTAL DATA ... BIOMECHANICS, PATHOGENESIS, BONES, BLATTIDAE ...

... BONE FRACTURES, EXPERIMENTAL DATA, POROSITY, FEEDBACK, HYPOTHESES, ACCUMULATION, INHIBITION, PATHOGENESIS, BONES, ...

... activity and optimal amounts of hormones, vitamins, and minerals, trabecular bone develops into a complex lattice structure that is lightweight but strong. Bones ...

The aetiology of profound hearing loss in children is complex and multifactorial. Congenital inner ear abnormality is a major cause of hearing loss in children. CT temporal bone imaging is the modality of choice in the investigation of hearing loss. Recognising the congenital abnormalities of the inner ear guides the clinician's ...

We developed a computer-aided diagnostic (CAD) scheme for assisting radiologists in the detection of asymmetric abnormalities on a single whole-body bone scintigram by applying a contralateral subtraction (CS) technique. Twenty whole-body bone scans including 107 abnormal lesions in anterior ...

A new type of endoplasmic reticulum (ER) stress transducer, Old Astrocyte Specifically Induced Substance (OASIS), which is induced by bone morphogenetic protein-2 (BMP2), has been reported to activate the transcription of type I collagen and contribute to the secretion of bone matrix proteins in osteoblasts. Here, we examined the role of OASIS in fracture ...

Individuals with nerofibromatosis Type 1 (NF1) frequently suffer a spectrum of bone pathologies, such as abnormal skeletal development (scoliosis, congenital bowing, and congenital pseudoarthroses, etc), lower bone mineral density with increased fracture risk. These skeletal problems may result, in part, from ...

Pinna abnormalities and low-set ears refer to abnormalities in the shape or position of the outer ear (pinna ... critical organs are developing (such as the kidneys). Abnormalities in the shape or position of the pinna ...

With the awareness of osteoporosis as a major health problem for an aging population, there is great interest in early recognition and treatment of abnormal bone loss. Effective prevention of bone loss has to occur prior to the occurrence of irreparable damage. Standard radiographic procedures are not sensitive enough for the task. ...

... TITLE: Bone Marrow Function in Development of Childhood Asthma ... Bone Marrow Function in Development of Childhood Asthma ...

... departments and agencies for Research Development Test and ... Title : WATER DISTRIBUTION ABNORMALITIES IN HYPOTHYROID DOGS DUE ...

... the military departments and agencies for Research Development Test and ... Title : Vascular Abnormalities Associated with Thermal and Electrical ...

... the military departments and agencies for Research Development Test and ... STUDIES ON THE NATURE OF THE ABNORMALITIES IN SOLUTE ...

... 0703 TITLE: Redox Abnormalities as a Vulnerability Phenotype for Autism and Related Alterations in CNS Development ...

... 0702 TITLE: Redox abnormalities as a vulnerability phenotype for Autism and related alternations in CNS development ...

... and analysis capabilities across the military departments and agencies for Research Development Test and ... Title : Platelet Abnormalities in Malaria. ...

... military departments and agencies for Research Development Test and ... Title : Molecular Mechanisms of Glial Abnormalities in Neurofibromatosis. ...

... capabilities across the military departments and agencies for Research Development Test and ... Title : Detection of Abnormalities in MANETs. ...

... military departments and agencies for Research Development Test and ... Title : DETECTING BURNING ABNORMALITIES IN A SOLID PROPELLANT ...

... military departments and agencies for Research Development Test and ... Title : DETECTING BURNING ABNORMALITIES IN A SOLID PROPELLANT ...

... the military departments and agencies for Research Development Test and ... Title : CHROMOSOME ABNORMALITIES IN LIVER AND MARROW OF ...

In this study, the autonomous proliferation of bone marrow progenitor cells (CFU-C), a pathological phenomenon observed in many hematological abnormalities, was investigated in 31 individuals who had been diagnosed as having neutropenia. Of these subjects, 18 had been chronically exposed (range of exposure 5-30 years) to a variety of petroleum distillates. ...

myo-Inositol (MI) plays an essential role in several important processes of cell physiology, is involved in the neural system, and provides an effective treatment for some psychiatric disorders. Its role in osteogenesis and bone formation nonetheless is unclear. Sodium/MI cotransporter 1 (SMIT1, the major cotransporter of MI) knockout (SMIT1(-/-)) mice with markedly reduced ...

A 37y/o male developed mass formation in right tibia in Oct. 1986. He had generalized lymphadenopathy. Diagnosis of malignant lymphoma of B cell type (follicular, large cell type) stage IV B was made because of bone marrow involvement. Surface marker analysis of pathologic cells in the peripheral blood, bone marrow, lymph nodes ...

Granulopoiesis was studied simultaneously by three methods in normal subjects and in subjects with neutropenia of various aetiologies: in vitro labelling of autologous and homologous granulocytes for the study of peripheral kinetics, in vivo labelling with DF$sup 32$P (di-isopropyl-fluorophosphate 32P) or $sup 75$Se-selenomethionine, and bone marrow autoradiography ...

Mice possessing no Has2 expression in chondrocytes died near birth and displayed abnormalities throughout their skeleton. By embryonic day 18.5, the long bones were short and wide, and possessed excessive mineralization within their diaphysis, with little evidence of diaphyseal bone modeling. However, this does not appear to be ...

ABSTRACT: Hydatid disease is common in many parts of the world, and causes considerable health and economic loss. This disease may develop in almost any part of the body.Bone involvement is often asymptomatic, and its diagnosis is primarily based on radiographic findings. A whole body bone scan is able to show the extent and ...

Hydatid disease is common in many parts of the world, and causes considerable health and economic loss. This disease may develop in almost any part of the body.Bone involvement is often asymptomatic, and its diagnosis is primarily based on radiographic findings. A whole body bone scan is able to show the extent and distribution of ...

An ankylosed tooth and adjacent alveolar process can lead to the development of an open bite, an unesthetic smile line, and abnormal function in mastication. Intraoral alveolar bone distraction osteogenesis is an option for treating an ankylosed tooth. The purpose of this clinical report was to show the treatment of a growing patient ...

Intravenous administration of bone marrow to gravid rabbits subjected to a single whole-body x-ray dose lethal for fetuses (700 r) improved the course of radiation sickness in rabbits and in some of them preserved the progeny. However, in newborn rabbits there were signs of radiation injury and developmental abnormalities in most cases. In ...

In an attempt to determine the pathological significance of a long arm deletion of chromosome 13 (13q-) in bone marrow failure syndrome, we reviewed the clinical records of nine patients who were initially diagnosed with aplastic anaemia due to bone marrow hypoplasia without dysplasia. Six patients responded to immunosuppressive therapy and the other three ...

Testosterone is vital to normal growth and development of sex and reproductive organs. It controls the development of secondary male sex characteristics like musculature, bone mass, and vocal chord thickening. Also, testosterone helps maintain energy level, mood, fertility, and sexual desire in both males and females. In males, ...

Gaucher Disease (GD) is a lysosomal storage disorder due to glucocerebrosidase (GBA) deficiency. Mechanisms leading to the emergence of haematological and skeletal manifestations observed in GD are poorly explained. Bone marrow (BM) mesenchymal stem cells (MSCs) are multipotents progenitors which participates to the regulation of bone mass. MSCs should ...

... is the abnormal growth of bone of the middle ear. This bone prevents structures within the ear ... The ear has three main parts: the outer, middle, and inner ear. Sound waves enter through the ...

SummaryHereditary multiple exostoses (HME) is a genetically heterogeneous human disease characterized by the development of bony outgrowths near the ends of long bones. HME results from mutations in EXT1 and EXT2, genes that encode glycosyltransferases that synthesize heparan sulfate chains. To study the relationship of the disease to mutations in these ...

The capacity of bone tissue to alter its mass and structure in response to mechanical demands has long been recognized but the cellular mechanisms involved remained poorly understood. Bone not only develops as a structure designed specifically for mechanical tasks, but it can adapt during life toward more efficient mechanical ...

Acute myeloid leukemia (AML) is a hematopoietic disorder in which there are too many immature blood-forming cells accumulating in the bone marrow and interfering with the production of normal blood cells. It has long been recognized that AML is a clinically heterogeneous disease characterized by a multitude of chromosomal abnormalities and gene mutations, ...

Bone scintigraphs obtained with both technetium-99m polyphosphate and technetium-99m pyrophosphate have been abnormal at the sacroiliac joints of 44 patients with definite ankylosing spondylitis (AS). Because of the normal registration of the sacroiliac joints on bone scintigraphy, it has been necessary to develop ...

We examined and described the development and abnormalities of the axial skeleton in 10 human trisomy 18 fetuses. Whole-body radiographs and radiographs of midsagittal tissue blocks of the cranial base and the spine were studied. In 3 fetuses no spinal radiographs were available. Seven osseous regions or fields along the body axis were analyzed, four in ...

The development of skeletal lesions in two canine models of GM1-gangliosidosis, English springer spaniels and Portuguese water dogs, has been studied and compared to osseous abnormalities in a child with the infantile form of the disease. In the canine models, skeletal dysplasia was progressive. Lesions were noted at 2 months of age and characterized by ...

Growth is a physiologically demanding process that requires adequate amounts of energy as well as optimal intake of essential nutrients. Key nutritional factors, including energy and calcium, have been identified as important during growth. Large-breed puppies have a genetic tendency toward fast growth rates that can stress developing skeletal structures and result in ...

A patient with severe anemia, reticulocytopenia, and erythroid hyperplasia of the bone marrow developed fatal acute nonlymphocytic leukemia after 3 yr. A Philadelphia chromosome with the typical 9/22 translocation was identified by banding techniques in a small number of bone marrow cells throughout the preleukemic phase of the illness ...

Cancer that starts in a bone is rare. Cancer that has spread to the bone from another ... more common. There are three types of bone cancer: Osteosarcoma - develops in growing bones, usually between ages ...

Cartilage-associated protein (CRTAP) is an essential cofactor for the proper post-translational chain modification and collagen folding. CRTAP mutations lead in mice (Crtap?/? mice) and humans (OI type VII) to a severe/lethal osteochondrodystrophy; patients have fractures at birth, deformities of the lower extremities and impaired growth. The consequences of CRTAP deficiency on intrinsic ...

The weightlessness experienced in space produces alterations in calcium homeostasis. Gemini, Apollo, and Skylab astronauts exhibited a negative calcium balance due primarily to hypercalciuria. In addition, the bone mineral density of the calcaneus declined by approximately 4% in Skylab crew members after 84 d of orbital flight. The negative calcium balance and loss of ...

... 2002) estimated that about 2% of the koalas (Phascolarctos cinereus) examined at his veterinary lab at the University ... ...

... We have been studying a family of proteins ... NEOPLASMS, CHROMOSOMES, IMMUNOASSAY, ABNORMALITIES, SKELETON, HIGH SENSITIVITY ...