Development of cardiac arrhythmias in several degenerative cardiac disorders such as heart failure is precipitated by abnormalities in intracellular calcium regulation. Recently, the identification of mutations in proteins responsible for the control of intracellular calcium has been associated with an inherited arrhythmogenic syndrome ...

Duchenne muscular dystrophy patients lack the protein dystrophin which is an essential link in the complex of proteins that connect the cytoskeleton to the extracellular matrix. In mechanically stressed tissues such as muscle, transient sarcolemmal microdisruptions are normal, but in dystrophic muscle cells the frequency of these microdisruptions is greatly increased. Although both normal and ...

Within the cardiac cell, the movements of calcium ions are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part responsible for orchestrating these movements for the normal functioning of the cardiomyocyte. Alterations of SR regulatory proteins in failing hearts leads to ...

Within the cardiac cell, the movements of calcium ions are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part responsible for orchestrating these movements for the normal functioning of the cardiomyocyte. Alterations of SR regulatory proteins in failing hearts leads to ...

Long-term treatment of patients with chronic renal insufficiency has been carried out by increasing the dialysate calcium concentration to 7-8 mg/dl and decreasing the plasma phosphorus concentration to

Alzheimer's disease (AD) is defined by senile plaques made of amyloid-beta peptide (Abeta), neurofibrillary tangles made of hyperphosphorylated tau proteins, and memory deficits. Thus, the events initiating the cascade leading to these end points may be more effective therapeutic targets than treating each facet individually. In the small percentage of cases of AD that are genetic (or animal ...

Alzheimer�s disease (AD) is defined by plaques made of amyloid-? peptide (A?), tangles made of hyper-phosphorylated tau proteins and memory deficits. Thus, the events initiating the cascade leading to these end points may be more effective therapeutic targets than treating each facet individually. In the small percentage of cases of AD that are genetic (or animal models that reflect this form of ...

... Keywords: Calcium homeostasis, Macrophages, Lysosomes. Descriptors : *CALCIUM, *BACTERIAL TOXINS, *CELL STRUCTURE ...

Calcium and phosphate play a key role in bone mineralization but have also many other physiological functions. The control of serum phosphate concentration is mandatory to avoid the occurrence of severe metabolic disorders, but is less tightly regulated than serum ionized calcium concentration, which is maintained in a very limited range thanks to ...

... 10- Page 5. 19. Abstract (Cont.) calcium homeostasis was examined. Using Quin-2 as a calcium probe for cytosolic calcium ...

Teaching Ca2+ and phosphate homeostasis in a physiology survey course for medical or graduate students is done very effectively with an integrated approach.

Autism spectrum disorder (ASD) is a severe, complex neurodevelopmental disorder characterized by impairments in reciprocal social interaction and communication, and restricted and stereotyped patterns of interests and behaviors. Recent evidence has unveiled an important role for calcium (Ca(2+)) signaling in the pathogenesis of ASD. Post-mortem studies of autistic brains have ...

Calcium homeostasis is controlled both directly and by hormones. Directly as a result of the fact that the uptake of calcium from the intestine and its excretion by the intestine, kidney and skeleton are well attuned to one another. A process of diffusion of calcium through the intestinal wall occurs in addition to ...

The endoplasmic reticulum (ER) is the main site of protein and lipid synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium storage, and perturbation of ER homeostasis leads to stress and the activation of the unfolded protein response. Chronic activation of ER stress has been shown to have an important role in the development of ...

Abnormalities of calcium, phosphorus and magnesium homeostasis are common, and collectively are called disorders of mineral metabolism. Normal homeostatic regulation maintains serum levels, intracellular levels, and optimal mineral content in bone. This regulation occurs at three major target organs, the intestine, kidney and bone, ...

Prion-related disorders (PrDs) are fatal neurodegenerative disorders characterized by progressive neuronal impairment as well as the accumulation of an abnormally folded and protease resistant form of the cellular prion protein, termed PrP^RES. Altered endoplasmic reticulum (ER) homeostasis is associated with the occurrence of ...

To escape aging and aging-related disorders has been one of mankind's biggest dreams from the beginning of history. However, our knowledge regarding the molecular mechanisms of aging has been limited. We recently developed a unique short lifespan mouse strain in which a single gene mutation caused multiple aging-related disorders and identified the responsible gene as klotho. The most ...

... We will speculate that the disruption of calcium homeostasis by a wide variety of chemicals and the conditions of their use might provide an ...

... To explore the intracellular mechanism of inhibition of secretion by TT, cellular calcium homeostasis was examined. Using ...

... Title : Evaluation of the Mechanism of Immunosuppression and Calcium Homeostasis by an Immunosuppressive Trauma Peptide. ...