Chronic kidney disease (CKD) is a major risk factor for the development of cardiovascular disease (CVD). Abnormalities of renal hemodynamics are associated with CKD. Abnormalities in renal hemodynamics include blood flow into glomeruli, and tubulointerstitial tissue. Renin-angiotensin system, oxidative stress and ...

We evaluated the effects of moderate-to-severe impairment of the estimated glomerular filtration rate (eGFR: 15 to 59?mL/min per 1.73?m(2)) and of proteinuria on the central hemodynamics and the pulse wave velocity (PWV) in 2244 middle-aged healthy Japanese men who were not receiving any medications for cardiovascular diseases or cardiovascular risk ...

We evaluated the effects of moderate-to-severe impairment of the estimated glomerular filtration rate (eGFR: 15 to 59?mL/min per 1.73?m²) and of proteinuria on the central hemodynamics and the pulse wave velocity (PWV) in 2244 middle-aged healthy Japanese men who were not receiving any medications for cardiovascular diseases or ...

... pathological changes in the lung related to abnormal lung fluid balance, altered pulmonary capillary hemodynamics, and possible pulmonary hypertension. ...

The aim of this study was to evaluate the effect of sildenafil on ocular hemodynamics in a group of men with erectile dysfunction in 3 months regular use. A total of 15 patients with erectile dysfunction were included in this prospective study. All patients received 50 mg doses of sildenafil (Viagra, Pfizer) two times per week regularly for 3 months. The following examinations ...

Although resting hemodynamic load has been extensively investigated as a determinant of left ventricular (LV) hypertrophy, little is known about the relationship between provoked hemodynamic load and the risk of LV hypertrophy. We studied central pressure-flow relations among 40 hypertensive and 19 normotensive adults using carotid ...

The renal and hemodynamic responses of squirrel monkeys to central vascular volume expansion induced

In atherosclerotic internal carotid artery (ICA) or middle cerebral artery (MCA) disease, hemodynamic compromise may cause selective neuronal damage manifested as loss of central benzodiazepine receptors (BZRs) in the normal-appearing cerebral cortex, without overt episode of stroke. To investigate the association of decreases in cortical BZRs with ...

In atherosclerotic internal carotid artery (ICA) or middle cerebral artery (MCA) disease, hemodynamic compromise may cause selective neuronal damage manifested as loss of central benzodiazepine receptors (BZRs) in the normal-appearing cerebral cortex, without overt episode of stroke. To investigate the association of decreases in cortical BZRs with ...

Pneumoperitoneum with CO2 is associated with adverse effects, such as hypercarbia, arrhythmias, and circulatory depression, which may limit its use in patients with underlying disease. Some of these effects may be caused by CO2 absorption resulting in acid-base disturbances. Laparoscopic insufflation with helium may be a good alternative for CO2, since it is chemically inert. Because there are few ...

The administration of relatively small doses of E. coli endotoxin into the lateral ventricles results in the death of dogs. The study documents hemodynamic, respiratory and metabolic alterations which follow the introduction of endotoxin into the central ...

Therapeutic trials were conducted with hyperbaric oxygenation on outbred 12-18 kg dogs subjected to a gunshot wound with skeletal damage. The animals were divided into groups on the basis of treatment and subjected to central hemodynamic and ventilatory m...

The initiation and progression of cerebral aneurysms are degenerative processes of the arterial wall driven by a complex interaction of biological and hemodynamic factors. Endothelial cells on the artery wall respond physiologically to blood-flow patterns. In normal conditions, these responses are associated with nonpathological tissue remodeling and adaptation. The ...

Patients with congenital heart diseases (CHD) are confronted with early- and late-onset complications, such as conduction disorders, arrhythmias, myocardial dysfunction, altered coronary flow, and ischemia, throughout their lifetime despite successful hemodynamic and/or anatomical correction. Rhythm disturbance is a well-known and increasingly frequent cause of morbidity and ...

Indices of hemodynamics, some renal functions and mechanisms of their regulation were studied in 29 patients with ischemic heart disease and chronic circulatory insufficiency (grade IIA) and in 27 healthy persons under load conditions. Indices of central hemodynamics and renal function deteriorated in the patients after increase of ...

A study of 40 patients with duodenal ulcer by means of methods of variational pulsimetry and tetrapolar rheography revealed noncoordination of the regulation of the central and regional hemodynamics after intake of food. Atropin produced an inhibitory effect on the central hemodynamics, reduction of blood volume in ...

Hemodynamic responses and antidiuretic hormone (ADH) were measured during body position changes designed to induce blood volume shifts in ten cardiac transplant recipients to assess the contribution of cardiac and vascular volume receptors in the control ...

A hemodynamic abnormality such as hypovolemia or congestive heart failure frequently does not occur clinically as a discrete event, but rather may unfold in a sequence of clinical phases or �scenes�. This paper describes a prototype computer-based system being built to diagnose hemodynamic abnormalities by ...

156 children of the main group, born to parents irradiated in the result of Chernobyl disaster have been involved in the study. These children were identified with isolated abnormal chords of the left ventricle (AHLV) according the results of Doppler echocardiography. 39 practically healthy children and 24 children of the nosology control group have also been observed. ...

Comparison of Availability for Prediction of Volume Responsiveness; Comparison of Limits of Agreement for Invasive and Non-invasive Measurement of Stroke Volume Variation

When a physiological (exercise) stress echo is scheduled, interest focuses on wall motion segmental contraction abnormalities to diagnose ischemic response to stress, and on left ventricular ejection fraction to assess contractile reserve. Echocardiographic evaluation of volumes (plus standard assessment of heart rate and blood pressure) is ideally suited for the quantitative ...

Historically, and at present, carbon monoxide is a major gaseous poison responsible for widespread morbidity and mortality. From threshold to maximal nonlethal levels, a variety of cardiovascular changes occur, both immediately and in the long term, whose homeostatic function it is to renormalize tissue oxygen delivery. However, notwithstanding numerous studies over the past century, the ...

Clinical, electrocardiographic and hemodynamic studies were made in thirty-one patients with louse-borne relapsing fever in Ethiopia; more detailed physiologic studies were made in a further nineteen patients. Evidence of an abnormal myocardium was obtain...

Previous studies of heavy metal salt-induced acute renal failure demonstrated abnormalities of fluid and solute transport by nephron segments and alterations in glomerular filtration rate and renal hemodynamics. To determine the direct effects of uranyl n...

development of many North American anurans (e.g., Rana catesbeiana) is not a con- tinuous but rather.50 Copyright 0 1991 the American Physiological Society #12;HEMODYNAMICS IN LARVAL RANA CATESBEIANA R241 of central circulatory system of Rana catesbeiana larvae. Appearance of spiral valve in conus arter- iosus

Hypertension is a multifaceted hemodynamic abnormality which cannot be characterized only by considerations of cardiac output and calculated systemic resistance. The spectrum of its hemodynamic patterns has been shown to be much wider than a monotonous increase in resistance with normal or reduced output. Disturbances of extracellular ...

In a double-blind, placebo-controlled study, the central and peripheral hemodynamic effects of 100 mg oral flosequinan and the impact of this drug on neurohormonal activation were noninvasively evaluated in 18 patients with congestive heart failure, after the first administration and after 10 days of treatment. No significant ...

An approach that can help clarify mechanisms of central circulation of orthostatic men using a mathematical model and noninvasive methods of examination is described. Circulation parameters such as peripheral resistance, arterial compliance, and ratio of ...

Background- Abnormal microvolt T-wave alternans (MTWA), a marker of ventricular arrhythmic risk, is a highly prevalent condition in patients with type 2 diabetes mellitus (T2DM) and is correlated with glycemic control. However, there is uncertainty as to whether central or peripheral hemodynamic factors are associated with ...

Hemodynamics is thought to play a major role in heart development, yet tools to quantitatively assess hemodynamics in the embryo are sorely lacking. The especially challenging analysis of hemodynamics in the early embryo requires new technology. Small changes in blood flow could indicate when anomalies are initiated even before ...

The authors presented the results of a clinical use of a new radiocardioanalyzer RKA 3-01 (manufactured in the USSR) providing for automated measurements and computations of indices of the central hemodynamics during studies using a method of dilution of radioactive nuclides. The main technical potentialities of the device designed on the basis of ...

Radionuclide angiocardiography provides a noninvasive assessment of cardiac function and blood flow through the heart and lungs. During the past three years, this procedure has been used at the Duke University Medical Center for evaluation of 343 patients with congenital heart disorders. A review of this experience shows tat the resulting data were frequently useful in the surgical management of ...

This edition of Microcirculation presents five current and emerging perspectives of the microcirculation in development, health and disease. The onset of blood flow and pressure are central to cardiovascular development. These hemodynamic forces are explored in light of underlying molecular signaling pathways that affect vascular and cardiac cell shape and ...

Increasing evidence suggests that natriuretic peptides (NPs) play diverse roles in mammals, including renal hemodynamics, neuroendocrine, and cardiovascular functions. Collectively, NPs are classified as hypotensive hormones; the main actions of NPs are implicated in eliciting natriuretic, diuretic, steroidogenic, antiproliferative, and vasorelaxant effects, important factors ...

IntroductionMethemoglobinemia is a rare cause of hypoxemia, characterized by abnormal levels of oxidized hemoglobin that cannot bind to and transport oxygen.Case presentationA 62-year-old male underwent bronchoscopy where lidocaine oral solution and Hurricaine spray (20% benzocaine) were used. He developed central cyanosis and his oxygen saturation was 85% ...

BACKGROUND AND OBJECTIVES: Insulinoma is the most common pancreatic endocrine tumor and it can be associated with multiple endocrine neoplasia (MEN). This is a report on a patient with multiple endocrine abnormalities, who did not fulfill the criteria of known syndromes (MEN) and the clinical-anesthetic particularities that influenced the anesthetic management. CASE REPORT A ...

The advances in ultrasound technology have made it possible to identify fetal structural abnormalities and genetic syndromes in the first trimester. First trimester prenatal diagnosis of fetal central nervous system, renal, gastrointestinal, cardiac, and skeletal abnormalities is reviewed. PMID:11981912

Chronic renal failure (CRF) is known to have adverse effects on the neurodevelopmental outcome of affected children. Some of these effects can be ameliorated by transplantation (TX). The cause and nature of the underlying brain injury is not known. We performed a brain magnetic resonance imaging (MRI) study on a group of children after TX to look for brain abnormalities and, ...

The analysis of intraoperative hemodynamic, metabolic, and coagulation disorders of the recipients in relation to the newly reperfused organ during intestinal transplantation is necessary for an optimal patient management during small bowel transplantation (SBT). The interaction may be minor or may lead to postreperfusion syndrome, producing intense ...

In rats, the acute central dipsogenic and natriuretic action of angiotensin II (AngII) seems to be independent of the hemodynamic effects of the peptide; however, in genetically hypertensive models, this relationship has not yet been investigated. It has been demonstrated that AngII induces the suppressor of cytokine signaling (SOCS-3) expression in the ...

: The aim of this work was to apply the fuzzy inductive reasoning (FIR) methodology and both time-delay and recurrent neural networks (TDNNs and RNNs) to induce models of the central nervous system (CNS) control that accurately represents the input/output behavior available from observations of a particular patient. A comparative study of these approaches from the point of ...

Central arterial hemodynamic changes were assessed during cooling, hypothermia, and rewarming in splenectomized (SPX, n = 4) and unsplenectomized (SP, n = 4) 8-10 month old male Yucatan miniature swine (34.0 % 1.4 kg). Under isoflurane anesthesia, and usi...

... Child Neurol . 2007;22:176-184. Kinsman SL, Johnston MV. Congenital Abnormalities of the Central Nervous System. ...

Etomidate has been used since 1972 as an inductor and in maintaining anesthesia. There are multiple mechanisms that account for the biologic effects of etomidate. One of the most prominent features of this drug is that it provides anesthesia without gross changes in hemodynamic parameters. This feature allows using etomidate in patients with considerable cardiopulmonary ...

Patent ductus arteriosus in extremely premature babies is associated with major neonatal morbidities, such as necrotizing enterocolitis and intraventricular hemorrhage. This may be attributable, at least in part, to systemic hypoperfusion secondary to ductal steal. A hemodynamically significant ductus arteriosus (HSDA) is known to be associated with altered systemic blood flow ...

OBJECTIVESThe objectives of this study were to examine the circulatory changes experienced by the immature systemic and cerebral circulations during routine events in the critical care of preterm infants and to identify clinical factors that are associated with greater hemodynamic-oxygenation changes during these events.METHODSWe studied 82 infants who weighed <1500 g at ...

Background and Aim:Rheumatic fever is still a common cause of acquired heart disease in children and young adult in many developing countries. The aim was to investigate the role of myocardial involvement in the hemodynamic changes in patients with acute rheumatic fever using cardiac troponin assay and echocardiography. Design: A prospective cohort study was designed.Patients ...

Exercise-induced abnormalities during thallium-201 scintigraphy that normalize at rest frequently occur in patients with hypertrophic cardiomyopathy. However, it is not known whether these abnormalities are indicative of myocardial ischemia. Fifty patients with hypertrophic cardiomyopathy underwent exercise {sup 201}Tl scintigraphy and, during the same ...

Rheo- and radioencephalography were used to determine the cerebral circulation, the blood pressure in the central retinal artery of the eye, and the temporal artery to evaluate the state of cerebral hemodynamics. The values obtained in young, healthy, adu...

The present work proceeds from a survey of microwave systems and devices to consideration of microwave ..... of central hemodynamics in athletes with those in nonathletes ..... might require drug treatment. A program to reduce cardiovascular ...... of alcohol was greater. Family configuration had no effect on ...

Studies performed under this grant provided evidence that tissue injury and hypoperfusion activate systemic and central neural, hormonal and opiate mechanisms that regulate the hemodynamic, metabolic and proinflammatory counter regulatory responses involv...

Cardiac function of monkeys was examined at different time intervals after electrode and transducer implantation. The study was carried out using 26 rhesus monkeys under ketalar anesthesia. The effect of this surgical intervention depended upon the initia...

ObjectiveLung inflammation causes perivascular fluid cuffs to form around extra-alveolar blood vessels; however, the physiologic consequences of such cuffs remain poorly understood. Herein, we tested the hypothesis that perivascular fluid cuffs, without concomitant alveolar edema, are sufficient to decrease lung compliance.DesignProspective, randomized, controlled study.SettingResearch ...

The indices of central hemodynamics and renin-angiotensine-aldosterone system, as well as their relationship, were studied in patients with aggravated Icenko-Cushing's disease. A stable high arterial pressure, a raised total peripheral resistance, a decreased cardiac index, an increased blood corticotrophin, cortisol and aldosterone levels and an enhanced ...

Circulatory failure is a major cause of mortality and morbidity in critically ill newborn infants. Since objective measurement of systemic blood flow remains very challenging, neonatal hemodynamics is usually assessed by the interpretation of various clinical and biochemical parameters. An overview is given about the predictive value of the most used indicators of circulatory ...

Many of the risks associated with central venous access are well recognized. We report a case of inadvertent lymphatic disruption during the insertion of a tunneled central venous catheter in a patient with raised left and right atrial pressures and severe pulmonary hypertension, which led to significant hemodynamic instability. To our ...

Blood pressure waveform analysis may permit continuous (i.e., automated) and less invasive (i.e., safer and simpler) central hemodynamic monitoring in the intensive care unit and other clinical settings without requiring any instrumentation beyond what is already in use or available. This practical approach has been a topic of intense investigation for ...

Blood pressure waveform analysis may permit continuous (i.e., automated) and less invasive (i.e., safer and simpler) central hemodynamic monitoring in the intensive care unit and other clinical settings without requiring any instrumentation beyond what is already in use or available. This practical approach has been a topic of intense investigation for ...

The prevalence of cardiac abnormalities in patients with adolescent idiopathic scoliosis in an Asian population has not been reported. A retrospective study was conducted to evaluate the incidence of cardiac abnormalities in these patients. From January 2007 to April 2009, echocardiography and pulmonary function tests were performed in 80 adolescent ...

The venous compartment has an important function in regulation and control of cardiac output. Abnormalities of cardiac output have been found in early gestational stages of both early- and late-onset pre-eclampsia. The venous compartment also maintains the balance between circulating and non-circulating blood volumes and regulates the amount of reserve blood stored in the ...

Nearly half of all patients who have heart failure have preserved ejection fraction (HFpEF). Patients who have HFpEF tend to be older, female, and hypertensive, and characteristically display increased ventricular and arterial stiffening. In this article, we discuss the pathophysiology of abnormal ventriculoarterial stiffening and how it affects ventricular function, ...

An array of metabolic, hemodynamic, and renal abnormalities constitutes the cardiometabolic syndrome. A hallmark of this syndrome is visceral obesity and associated insulin resistance/hyperinsulinemia. The syndrome is also associated with essential hypertension, abnormalities in the circadian rhythm of blood pressure and heart rate, ...

Cor triatriatum is a rare malformation, especially in association with tetralogy of Fallot, and has only been reported a few times in the literature. Due to the complexity of this abnormality, careful intraoperative exploration and a good differential diagnosis are crucial to select the appropriate surgical procedure. Here, we report a case with this rare combination of ...

Cranio-thoracic trauma is characterized by severity of the pathologic process, peculiarities of the diagnosis, and a high mortality rate. However, problems concerning the correlation of hemodynamic and gas exchange disorders in patients with cranio-thoracic trauma, according to the principal factor of the damage, have been insufficiently studied. The purpose of the research ...

portions of Nebraska, Kansas, and South Dakota. Western Wyo- ming, where drought conditions are ongoing of North Dakota, western and central South Dakota, central Wyoming, and pockets of Kansas. The precipitation in south central Kansas and western North Dakota helped eliminate the abnormally dry conditions

The pulmonary valve consists of 3 leaflets and is similar in anatomy to the aortic valve. It is the least likely to be affected by acquired disease, and thus, most disorders affecting it are congenital. The most common hemodynamic abnormality of the pulmonary valve is the congenitally narrowed domed valve of pulmonic stenosis. Pulmonary stenosis is usually ...

Despite optimization of standard medical therapy, some patients with chronic heart failure will deteriorate to the point that they require hospitalization for intravenous therapies and inpatient monitoring. Once the condition is recognized, the therapeutic goals are to reverse hemodynamic derangements, correct metabolic abnormalities, and provide ...

This book covers the major applications of vascular ultrasonography, including cerebral, extremity, and abdominal vascular diagnosis. Hemodynamics, physics, instrumentation, the cerebrovascular system, the extremity vasculature, the abdominal vasculature, and postoperative vascular examination are all covered. The rational for examination, the technique for examination, and ...

The rate adaptive sensors applied to cardiac pacing should respond as promptly as the normal sinus node with an highly specific and sensitive detection of the need of increasing heart rate. Sensors operating alone may not provide optimal heart responsiveness: central venous pH sensing, variations in the oxygen content of mixed venous blood, QT interval, breathing rate and ...

The rate adaptive sensors applied to cardiac pacing should respond as promptly as the normal sinus node with an highly specific and sensitive detection of the need of increasing heart rate. Sensors operating alone may not provide optimal heart responsiveness: central venous pH sensing, variations in the oxygen content of mixed venous blood, QT interval, breathing rate and ...

Abnormalities of the Brainstem Serotonergic System in the Sudden Infant Death Syndrome: A Review October 12, 2005. Key words: arousal, brainstem, central chemosensitiv- ity, human, respiratory control, ventral medulla INTRODUCTION Sudden infant death syndrome (SIDS) is the sud- den death of an infant

We report a case of an adult male who had received a gunshot to the abdomen 12�years earlier. He presented with manifestations of high-output congestive heart failure (CHF), aortic regurgitation (AR), and pulmonary septic embolism. Further investigation revealed an aortocaval fistula (ACF). Following endovascular repair of the ACF, we observed an immediate rise in systemic vascular resistance ...

Clinical assessment and vital signs are poor predictors of the overall hemodynamic state. Optimal measurement of the response to fluid resuscitation and hemodynamics has previously required invasive measurement with radial and pulmonary artery catheterization. Newer noninvasive resuscitation technology offers the hope of more accurately and safely ...

: The aim of this work was to apply the fuzzy inductive reasoning (FIR) methodology and both time-delay and recurrent neural networks (TDNNs and RNNs) to induce models of the central nervous system (CNS) control that accurately represents the input/output behavior available from observations of a particular patient. A comparative study of these approaches from the point of ...

Central vascular catheters are an integral part of caring for a pediatric intensive care patient, providing hemodynamic monitoring capabilities, reliable vascular access for hydration, medication administration, and blood sampling. However, central vascular catheters put the patient at risk for central ...

Acute alcohol intoxication results in impaired hemodynamic counterregulation to blood loss and is associated with an attenuated hemorrhage-induced release of catecholamines and AVP. We speculated that restoration of the neuroendocrine response to hemorrhage would improve mean arterial blood pressure (MABP) recovery during acute alcohol intoxication. Previously, we demonstrated ...

Chronic heart failure is associated with reduced exercise capacity. Altered diastolic function and reduced chronotropic response play an important role. However, there is no clear correlation between any hemodynamic parameter and exercise capacity. Peripheral factors, long overlooked, seem to play a major role. Altered peripheral vasodilatation, involving endothelial ...

Tomographic images of cerebral blood flow (CBF) and oxygen extraction fraction (OEF) using the 15O continuous inhalation technique, and positron emission tomography, were obtained from a patient with cerebral ischemia distal to an occluded left internal carotid artery. There was a focal mismatch between CBF and oxygen metabolism in the brain supplied by the middle cerebral artery where CBF was ...

Background and purposeHemodynamics is thought to play an important role in the mechanisms of aneurysm pathogenesis, progression and rupture. The purpose of this study was to define quantitative measures related to qualitative flow characteristics previously analyzed and to investigate their relationship to aneurysm rupture.MethodsThe hemodynamic ...

Although there is adequate evidence that bicuspid aortic valve (BAV) is an inheritable disorder, there is a great controversy regarding the pathogenesis of dilatation of the proximal aorta. The hemodynamic theory was the first explanation for BAV aortopathy. The genetic theory, however, has become increasingly popular over the last decade and can now be viewed as the clearly ...

The use of central venous catheters (CVCs) represents an important step in the management of the surgical, onco-hematology and critically ill patients. CVCs in neonates, like in adult patients, are mainly used to infuse hyperosmolar solutions, to take blood samples and for hemodynamic monitoring. The need for CVCs is higher in neonates than in adults. Poor ...

Most children with idiopathic central hypoventilation have symptoms at birth or shortly thereafter and have mutations of the PHOX2B gene. Those whose symptoms appear later usually have obesity and hypothalamic abnormalities. We describe a case of a boy who presented at 5 years of age with severe idiopathic central hypoventilation, but ...

ObjectiveTo determine whether contrast-enhanced harmonic ultrasonography can be used to predict the aggressiveness of prostate cancer.Materials and MethodsContrast-enhanced harmonic ultrasonography was performed in 103 patients suspected of prostate cancer before biopsy. Time intensity curves were reconstructed for systematic biopsy sites and sonographic abnormalities. The ...

... to heal, resulting in regeneration of appendages with mirror image symmetry (Shelton et al.,1981; Shelton, 1982). In this ... ...

... 1998, corresponding to the entire breeding period. Every new individual was marked by clipping of 2 toes on different limbs. Toe-clips ... ...

... like fishermen, should consult their solunar tables before wading into ... analogies/game theories; abnormal psychology and racial stereotyping; and ...

... should consult their solunar tables before wading into murky political ... approaches; chess analogies/game theories; abnormal psychology and racial ...

Every major vessel in the human body has a characteristic flow pattern that is visible in spectral waveforms obtained in that vessel with Doppler ultrasonography (US). Spectral waveforms reflect the physiologic status of the organ supplied by the vessel, as well as the anatomic location of the vessel in relation to the heart. In addition, the waveforms may be affected by age- and ...

One of the most common causes of human death is stroke, which can be caused by carotid bifurcation stenosis. In our work we aim at proposing a prototype of a medical expert system that could significantly aid medical experts to detect hemodynamic abnormalities (increased artery wall shear stress). Based on the acquired simulated data, we apply several ...

To define further the natural history and causative factors in exercise-related cardiac dysfunction in children and adolescents with sickle cell anemia (SS), we studied the results of 74 patients' initial and follow-up exercise tests. The follow-up study was done one to three years after the first study in 36 children and four to seven years after initial testing in 38 children. Split-plot ...

J Clin Hypertens (Greenwich). 2011;13:557-562. �2011 Wiley Periodicals, Inc. Failure of blood pressure (BP) to decline appropriately overnight (nondipping) is associated with increased risk. This may be due to inappropriately raised supine central BP and this study's first aim was to examine this hypothesis. Secondly, aortic stiffness, central ...

BackgroundAs the independent relationship between C-reactive protein (CRP) concentrations and central aortic blood pressures (BP) in populations with high CRP concentrations is uncertain, we aimed to evaluate this question in a community sample, 57% with CRP concentrations >3�mg/l (high cardiovascular risk).MethodsCentral aortic ...

OBJECTIVE:: Infants are potentially more susceptible to cell death mediated via glutamate excitotoxicity attributed to cardiopulmonary bypass. We hypothesized that ketamine, via N-methyl D-aspartate receptor blockade and anti-inflammatory effects, would reduce central nervous system injury during cardiopulmonary bypass. METHODS:: We randomized 24 infants, without chromosomal ...

Functional connectivity (FC) between brain regions is thought to be central to the way in which the brain processes information. Abnormal connectivity is thought to be implicated in a number of diseases. The ability to study FC is therefore a key goal for neuroimaging. Functional connectivity (fc) MRI has become a popular tool to make connectivity ...

Background: The "chronic cerebrospinal venous insufficiency" or "CCSVI" hypothesis, namely that multiple sclerosis (MS) is caused by abnormalities in the azygous and internal jugular veins with subsequent alterations in venous hemodynamics in the central nervous system, has been a dominant topic in MS care in Canada over the past year. ...

Background Elderly female hypertensives with arterial stiffening constitute a majority of patients with Heart Failure with preserved Ejection Fraction (HFpEF), a condition characterized by the inability to increase cardiac stroke volume (SV) with physical exercise. As SV is determined by the interaction between the left ventricle (LV) and its load, we wished to study the role of arterial ...