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1
Abnormal Anal Cytology in HIV-infected Women
2010-03-12

ObjectiveTo assess the prevalence of and risk factors for abnormal anal cytology and HPV infections in HIV-positive women.Study DesignWe conducted an observational single center study of 100 HIV-infected women with cervical and anal specimens obtained for cytology and high risk HPV testing with Hybrid Capture ...

PubMed Central

2
Vaginal and Cervical Cytology of the Early Puerperium.
1969-01-01

Cervical and vaginal smears were obtained from 160 women who had delivered one to eight days prior to cytologic examination. Preparations were examined for general morphology and graded for malignancy. The degree of cytologic abnormality was found to corr...

National Technical Information Service (NTIS)

3
American Society for Colposcopy and Cervical Pathology

... adolescents and young women with abnormal cytology and histology results. The ASCCP Consensus Guidelines ...more Practice Improvement ...

MedlinePLUS

4
Association of Cervical Cytology and HPV DNA Status During Pregnancy With Placental Abnormalities and Preterm Birth.
2011-08-01

The clinical implications of abnormal cervical cytology during pregnancy are unclear. Therefore, we performed the present study to determine the role of cervical cytologic screening during pregnancy in association with placental abnormalities and preterm birth. A review of ...

PubMed

5
Abnormal Cervical Appearance: What to Do, When to Worry?
2011-02-01

Many clinicians encounter cervical lesions that may or may not be associated with cytologic abnormalities. Such abnormalities as ectropion, Nabothian cysts, and small cervical polyps are quite benign and need not generate concern for patient or clinician, whereas others, including those ...

PubMed Central

6
Prevalence of anal cytological abnormalities in women with positive cervical cytology.
2011-05-01

The objective of this study was to estimate the prevalence of cytological abnormalities of the anal mucosa in women with positive cervical cytology, but without macroscopic anal lesion. Ultimately we postulated if the anal mucosa may be a reservoir of HPV, which would allow the reinfection of cervix. Forty-nine ...

PubMed

7
Cytology, liquid-based cytology and automation.
2011-05-31

Quality-assured, comprehensive, cytology-based population screening programmes have resulted in a substantial decline in the incidence of, and mortality from, cervical cancer. Cytology classification systems divide squamous cell abnormalities into low grade and high grade. Women with high-grade squamous ...

PubMed

8
Cytological Detection of Cervical Carcinoma with New Cytochemical Markers and Flow Microanalysis.
1976-01-01

Human cervical cell samples have been stained with mithramycin or chromomycin A3 in an effort to analyze such preparations for premalignant abnormal cells by flow cytometry. Fluorescence from mithramycin or chromomycin A3-stained cells is similar to the f...

National Technical Information Service (NTIS)

9
Cytology and cervical cancer surveillance in an era of human papillomavirus vaccination.
2010-09-01

Cytological and cancer surveillance will provide the most effective indications of short-term effects and long-term outcomes of the introduction of the human papillomavirus (HPV) vaccine in Australia. This article outlines how this surveillance is proposed to occur through the established national monitoring mechanisms of the National Cervical Screening ...

PubMed

10
Histological Correlation of Glandular Abnormalities in Cervical Liquid-Based Cytology
2011-09-22

Conventional Papanicolaou smear method is still commonly used for cervical cancer screening in Japan, despite the liquid-based cytology (LBC) that has become a global tendency in the world recently. One of the obstacles in the way of popularization of this method seems to be the confusion as to diagnosis upon cervical glandular ...

PubMed Central

11
Human Papillomavirus Infection and Cytologic Abnormalities of the Anus and Cervix Among HIV-Infected Women in the Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (The SUN Study).
2011-04-01

BACKGROUND:: Human papillomavirus (HPV) infection of the cervix and related abnormal cervical cytology in HIV-infected women has been well described. Little is known about anal HPV infection in HIV-infected women. METHODS:: The SUN Study is a prospective cohort study of 700 HIV-infected patients including 167 women. At baseline, ...

PubMed

12
Differences in cervical cytologic and histologic findings between women using depot-medroxyprogesterone acetate and oral contraceptives.
2011-07-01

OBJECTIVE.: This study aimed to compare cervical cytologic and histologic findings between women using depot-medroxyprogesterone acetate (DMPA) and oral contraceptives (OCs) referred for colposcopy and to determine whether there were differences in the occurrence of false-positive cytologic finding between the 2 contraceptive groups. ...

PubMed

13
Prevalence and risk factors for human papillomavirus DNA in cervical cytology.
2011-07-14

OBJECTIVES: This study aimed to detect the presence and prevalence of HPV-DNA in the cervical swab samples obtained from patients with cervical cancer, premalignant cervical lesions and benign cervical smear results, and to identify the potential risk factors influencing this prevalence. STUDY DESIGN: Smear ...

PubMed

14
Cervical cancer screening.
2005-10-01

Cervical cytology has proved to be one of the most successful examples of cancer screening and has resulted in significant decreases in incidence and mortality from invasive cervical cancer in regions in which comprehensive programs have been instituted. A standardized system of reporting abnormal ...

PubMed

15
Risk of significant gynaecological pathology in women with ?glandular neoplasia on cervical cytology.
2011-07-12

A. Talaat, D. Brinkmann, J. Dhundee, Y. Hana, J. Bevan, R. Irvine, S. Bailey and R. Woolas Risk of significant gynaecological pathology in women with ?glandular neoplasia on cervical cytology Objective:? To review the risk of pre-invasive and invasive gynaecological pathology in women referred with cervical ...

PubMed

16
Human Papillomavirus and Cervical Cancer
2003-01-01

Of the many types of human papillomavirus (HPV), more than 30 infect the genital tract. The association between certain oncogenic (high-risk) strains of HPV and cervical cancer is well established. Although HPV is essential to the transformation of cervical epithelial cells, it is not sufficient, and a variety of cofactors and molecular events influence ...

PubMed Central

17
Objective perspective in colposcopy.
2011-08-12

Colposcopy is a widely used diagnostic procedure, primarily in the assessment of women with abnormal cervical cytology. It is used by appropriately trained individuals using techniques that allow a full assessment of the abnormality and plan for further investigation or treatment. Certain key features are ...

PubMed

18
Cervical cytology screening in a sexually transmitted diseases clinic for the first time in Sri Lanka.
1989-04-01

A prospective study of cervical cytology was carried out on 350 consecutive female patients attending the central venereal diseases clinic (CVDC) in Colombo, Sri Lanka. The main objective was to assess the proportion of abnormal cervical smears to emphasise the need to introduce routine ...

PubMed Central

19
CASP8 promoter polymorphism is associated with high-risk HPV types and abnormal cytology but not with cervical cancer.
2011-04-01

Only a small fraction of women infected with human papillomavirus (HPV) progress to cervical cancer pointing to additional risk factors including host genetics that might play a role in development of cervical cancer. Caspase-8 (encoded by CASP8 gene) is crucial in generating cell death signals to eliminate potentially malignant cells. Genetic variation in ...

PubMed

20
Military Service, Life Span Sexual Assault Exposures, and Cervical Cytologic Abnormalities.
2011-08-11

Abstract Background: Little is known about the reproductive health of military women. This study sought to determine women Veterans' competing risk factors, including life span sexual assault (LSA) exposures, associated with recent and lifetime cervical cytologic abnormalities. Methods: This cross-sectional study of a retrospective ...

PubMed

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21
Internet-Based Cervical Cytology Screening Program
2005-04-01

... Abstract : Cervical cancer is theoretically completely preventable by effective screening using cervical cytology methods (the Pap test). ...

DTIC Science & Technology

22
The Abnormal Pap Smear: A Rationale for Follow Up
1983-04-01

Cervical intraepithelial neoplasia (CIN) is readily identifiable by cytology, so theoretically, most cases of invasive carcinoma should be preventable. Risk factors for carcinoma of the cervix are related to sexual activity, therefore screening should be similarly related. All women should have routine annual cytology as soon as they ...

PubMed Central

23
Conservative Management of Adolescents With Abnormal Cytology and Histology
2008-01-01

Adolescents remain vulnerable to human papilloma virus (HPV) infection because of certain physiologic characteristics inherent in this age group and common sexual behaviors, including lack of condom use. The commonness of HPV in this age group also results in frequent abnormal cytology. Fortunately, most of the infections are transient, with frequent ...

PubMed Central

24
Prevalence of Human Papilloma Virus Infections and Cervical Cytological Abnormalities among Korean Women with Systemic Lupus Erythematosus
2010-10-17

We performed a multicenter cross-sectional study of 134 sexually active systemic lupus erythematosus (SLE) patients to investigate the prevalence of and risk factors for high risk human papilloma virus (HPV) infection and cervical cytological abnormalities among Korean women with SLE. In this multicenter cross-sectional study, HPV ...

PubMed Central

25
Cervical Cancer Prevention (PDQ�)

Based on solid evidence, screening via regular gynecologic examinations and cytologic test (Papanicolaou smear) with treatment of precancerous abnormalities decreases the incidence and mortality of cervical cancer. Screening is not beneficial in detecting invasive cancer in women younger than 25 years because of the low prevalence of ...

Cancer.gov

26
Comparing Visual Inspection With Acetic Acid to Cytology in Detection of Precancerous Lesions of the Cervix in HIV-Infected Cambodian Women.
2011-03-25

PURPOSE: To compare Papanicolaou (Pap) smear readings to visual inspection with acetic acid (VIA) findings among HIV-infected women in Phnom Penh, Cambodia. METHODS: A total of 304 HIV-infected women presenting to the women's clinic at the Community Resource Center in Phnom Penh, Cambodia, were screened for cervical cancer by both Pap smear and VIA. The results of the 2 tests ...

PubMed

27
The status of cervical cytology in Swaziland, Southern Africa: A descriptive study
2009-08-06

Background:Cancer of the cervix is the most common cancer in women in Swaziland where most women never undergo cervical screening. The extremely high prevalence of HIV/AIDS in Swaziland complicates the management of preinvasive and invasive cervical cancer. The purpose of this study was to assess the current status of cervical ...

PubMed Central

28
Prevalence and genotype distribution of human papillomavirus in non-neoplastic cervical tissue lesion: Cervical erosion.
2011-11-01

Human papillomavirus (HPV) infection is the commonest sexually transmitted infection, which is associated with various clinical conditions, ranging from asymptomatic infection to malignant disease of the cervix. The aim of this study was to evaluate the prevalence and genotypic distribution of HPV in women with cervical erosion and to compare the results with those in women ...

PubMed

29
TITLE: Cervical Cancer Screening: A Review of a Cost Feasibility Study and Jurisdictional Survey
2010-01-01

In 2010, about 1300 Canadian women will be diagnosed with cervical cancer and approximately 370 women will die from the disease. 1 Cervical cancer incidence and mortality has declined due to screening for cervical cancer using the Papanicalaou (Pap) test. Pap testing results in earlier detection and treatment of ...

E-print Network

30
Screening for cervical cancer: a new scope for general practitioners? Results of the first year of colposcopy in general practice.
1987-05-23

A survey was carried out over one year of all the women who attended a colposcopy clinic in a general practice. During the year 1254 women underwent cytological screening in the practice and 197 of these underwent colposcopy. Of 79 women with abnormal smears that suggested cervical intraepithelial neoplasia, 62 (79%) were confirmed by ...

PubMed Central

31
The mildly abnormal cervical smear: patient anxiety and choice of management.
1996-05-01

Argument continues over the best management of women with a first mildly dyskaryotic cervical smear: should they be referred for prompt colposcopy, or should they be kept under cytological review, with recourse to colposcopy if the abnormality persists? One consideration is the amount of anxiety generated. We measured anxiety, ...

PubMed Central

32
Teenage cervical screening in a high risk American population
2011-05-31

Background:The new 2009 ACOG guideline for cervical cytology screening changed the starting age to 21 years regardless of the age of onset of sexual intercourse. However, many recent studies have shown a dramatic increase in the incidence of cervical epithelial abnormalities among adolescents within the past two ...

PubMed Central

33
Human papillomavirus vaccines: an update for gynecologists.
2008-09-01

Human papillomavirus (HPV) infections cause several common gynecologic problems. Oncogenic HPV infections are responsible for abnormal cervical cytology, cervical dysplasia, and cervical cancer. In 2006, a vaccine was introduced to prevent these common problems in women's health. The currently ...

PubMed

34
Anal cytology as a screening tool for anal squamous intraepithelial lesions.
1997-04-15

Anal squamous intraepithelial lesions (ASIL) are common in homosexual and bisexual men, and high-grade ASIL (HSIL) in particular may represent an anal cancer precursor. Cervical cytology is a useful screening tool for detection of cervical HSIL to prevent cervical cancer. To assess anal ...

PubMed

35
Is Removal of Asymptomatic Cervical Polyps Necessary? Histologic Findings in Asymptomatic Israeli Jewish Women.
2011-08-01

OBJECTIVE:: The purpose of the present study was to assess the frequency of abnormal histologic findings in polyps of asymptomatic Israeli Jewish women who are known to have a low incidence of cervical neoplasia. MATERIALS AND METHODS:: The medical records of Israeli Jewish women with histologically proven cervical polyps treated ...

PubMed

36
Automated screening of cervical smears using immunocytochemical staining: a possible approach.
1985-08-01

A preliminary analysis was undertaken to ascertain whether a Leitz TAS (Texture Analyse System) video camera system, which is computer controlled, could be used to detect abnormal cells in cervical smears. Immunocytochemical together with haemalum nuclear staining was used for the epithelial membrane antigen. It was possible to detect ...

PubMed

37
Women's preferences regarding options for management of atypical, borderline or low-grade cervical cytological abnormalities: a review of the evidence.
2011-06-01

M. Z. Sadique and R. Legood Women's preferences regarding options for management of atypical, borderline or low-grade cervical cytological abnormalities: a review of the evidence Objectives:? To review the evidence on women's preferences for and valuation of alternative management pathways following identification of low-grade ...

PubMed

38
Fatal invasive cervical cancer secondary to untreated cervical dysplasia: a case report.
2011-07-18

ABSTRACT: INTRODUCTION: Well-documented cases of untreated cervical intra-epithelial dysplasia resulting in fatal progression of invasive cervical cancer are scarce because of a long pre-invasive state, the availability of cervical cytology screening programs, and the efficacy of the treatment of both pre-invasive ...

PubMed

39
Fatal invasive cervical cancer secondary to untreated cervical dysplasia: a case report
2011-07-18

IntroductionWell-documented cases of untreated cervical intra-epithelial dysplasia resulting in fatal progression of invasive cervical cancer are scarce because of a long pre-invasive state, the availability of cervical cytology screening programs, and the efficacy of the treatment of both pre-invasive and ...

PubMed Central

40
Internet-Based Cervical Cytology Screening Program
2006-04-01

... AREAS, INSTRUCTION MANUALS, CYTOLOGY. Subject Categories : GENETIC ENGINEERING AND MOLECULAR BIOLOGY ANATOMY AND ...

DTIC Science & Technology

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41
Evaluation of Cervicography Screening for Cervical Cancer in ...

... Initial cervicography classification was compared with a referent diagnosis determined by histology and three cytologic tests, cytology, and ...

DTIC Science & Technology

42
Human Papillomavirus Infections in Primary Care
2007-12-01

Cervical cancer continues to be a leading cause of mortality worldwide. The incidence and mortality associated with invasive cervical cancer have declined significantly in developed countries due to widespread availability of screening with the Papanicolaou (Pap) test. However, the incidence and prevalence of non-invasive cervical ...

PubMed Central

43
Internet-Based Cervical Cytology Screening Program
2006-04-01

... the effective cervical cytology triage point using ... Internet-based telecytology system with hierarchical ... Massachusetts General Hospital, Boston, MA ...

DTIC Science & Technology

44
Cytological surveillance compared with immediate referral for colposcopy in management of women with low grade cervical abnormalities: multicentre randomised controlled trial
2009-07-28

Objectives To examine the effectiveness of cytological surveillance in primary care compared with immediate referral for colposcopic examination in women with low grade abnormal results on cervical cytology tests.Design Multicentre individually randomised controlled trial.Setting NHS cervical ...

PubMed Central

45
Cervical cytology screening and management of abnormal cytology in adolescents.
2009-02-01

The consensus guidelines recognize adolescents as a special group and allow for more conservative follow- up of abnormal cytology and histology. The guidelines recognize the role of high rates of HPV infection and reinfection in teens, along with high rates of clearance of HPV and low rates of invasive cervical cancer. Risks of ...

PubMed

46
Rapid prescreen of cervical liquid-based cytology preparations: Results of a study in an academic medical center.
2010-12-31

A rapid prescreening or rapid rescreening method for quality assurance in cervical cytology has been used in Europe and in Canada but has not been accepted in the United States. The rapid prescreen method was tested in a cytology laboratory that serves an academic medical center with a high-risk population for ...

PubMed

47
Evaluation of a Cervical Cancer Screening Program Based on HPV Testing and LLETZ Excision in a Low Resource Setting
2010-10-07

We conducted studies in Vanuatu to evaluate potential screening and treatment strategies to assist with control of cervical cancer. In a pilot study of 496 women, visual inspection and cytology were evaluated as screening tests for detection of CIN 2 or worse (CIN2+), observed in 21 of 206 subjects biopsied on the basis of abnormal ...

PubMed Central

48
The value of anal cytology and human papillomavirus typing in the detection of anal intraepithelial neoplasia: a review of cases from an anoscopy clinic
2005-04-01

Background: Previous studies have reached differing conclusions about the utility of anal cytology as a screening tool for anal intraepithelial neoplasia (AIN). There is a need also to establish whether HPV typing offers a useful adjunct to screening. Methods: We analysed data from 99 consecutive homosexual/bisexual male patients (89 HIV-1 positive) who underwent high ...

PubMed Central

49
Cigarette smoking is an independent risk factor for cervical intraepithelial neoplasia in young women: A longitudinal study?
2010-01-01

AbstractRepeated measurements of smoking, cervical human papillomavirus (HPV) status and sexual behaviour were used to measure the risk of high-grade cervical intraepithelial neoplasia (CIN) in relation to changes in smoking and cervical HPV status, and to explore the impact of smoking on the acquisition and duration of incident ...

PubMed Central

50
Risk of invasive cervical cancer in relation to clinical investigation and treatment after abnormal cytology: A population-based case-control study.
2010-12-09

A substantial proportion of women with cervical cancer that have participated in cervical screening have a history of an abnormal cytology result. Our objective was to assess the impact of histological investigation and treatment of women with abnormal cytology on the ...

PubMed

51
Outcomes of screening to prevent cancer: analysis of cumulative incidence of cervical abnormality and modelling of cases and deaths prevented
2003-04-26

ObjectiveTo determine the frequency of different outcomes in women participating in cervical screening.DesignAnalysis of screening records from 348?419 women, and modelling of cases of cervical cancer and deaths with and without screening.SettingCervical screening programme in Bristol.ResultsFor every 10?000 women screened from 1976 to ...

PubMed Central

52
Updated Guidelines for Papanicolaou Tests, Colposcopy, and Human Papillomavirus Testing in Adolescents
2008-07-23

Worldwide, cervical cancer is a major health concern for women of all ages; however the epidemiology and biology of human papillomavirus (HPV) infection differs in female adolescents and adults. In the United States, 50% of adolescent and young women acquire HPV within 3 years after initiating sexual intercourse, resulting in relatively high prevalence rates. Most infections, ...

PubMed Central

53
Clinical significance of hTERC gene amplification detection by FISH in the screening of cervical lesions.
2009-06-10

This study evaluated the clinical significance of hTERC gene amplification detection by fluorescence in situ hybridization (FISH) in the screening of cervical lesions. Cervical specimens of 50 high risk patients were detected by thin liquid-based cytology. The patients whose cytological results were classified as ...

PubMed

54
Lifetime effects, costs, and cost effectiveness of testing for human papillomavirus to manage low grade cytological abnormalities: results of the NHS pilot studies
2006-01-14

Objectives To predict the incremental lifetime effects, costs, and cost effectiveness of using human papillomavirus testing to triage women with borderline or mildly dyskaryotic cervical smear results for immediate colposcopy.Design Modelling study.Setting Three centres participating in NHS pilot studies, United Kingdom.Population Women aged 25-64 with borderline or mildly ...

PubMed Central

55
[Molecular diagnosis of HPV infections.
2011-08-17

Carcinogenic human papillomaviruses (HPV) cause the majority of cervical cancers and other anogenital cancers. Large randomized trials have shown that HPV testing can be efficiently used for primary cervical cancer screening. Other applications include the triage of abnormal cytology results and the follow-up of ...

PubMed

56
Cytologic follow-up of patients with invasive cervical carcinoma treated by radiotherapy
1982-02-01

In an 11-year study done at the Ottawa Civic Hospital, cytologic assessment of 323 patients treated by radiotherapy for invasive cervical carcinoma was reviewed. The value and limitations of gynecologic cytology in the follow-up of these patients are discussed.

Energy Citations Database

57
Inadequate follow-up for abnormal Pap smears in an urban population.
2003-09-01

PURPOSE: To determine the factors associated with inadequate follow-up for abnormal Pap smears among a cohort of Boston women from urban academic clinics. METHODS: Subjects were women > 18 years with abnormal cervical cytology between February 1999 and April 2000. Inadequate follow-up was defined as lack of ...

PubMed Central

58
How protective is cervical cancer screening against cervical cancer mortality in developing countries? The Colombian case
2010-09-16

BackgroundCervical cancer is one of the top causes of cancer morbidity and mortality in Colombia despite the existence of a national preventive program. Screening coverage with cervical cytology does not explain the lack of success of the program in reducing incidence and mortality rates by cervical cancer. To ...

PubMed Central

59
The prevalence of abnormal cervical cytology in women with infertility.
2010-11-01

The aim of this study was to compare the frequency of abnormal cervical cytology in women with infertility problems with that of fertile women by using ThinPrep� liquid-based Pap Tests�. A retrospective case-control study for over 2 years was conducted. The cases included all women with infertility problems who had Pap tests during ...

PubMed

60
Internet-Based Cervical Cytology Screening Program.
2005-01-01

Cervical cancer is theoretically completely preventable by effective screening using cervical cytology methods (the Pap test). The process of preparing and interpreting Pap tests remains one of the last high-volume manual processes in the clinical laborat...

National Technical Information Service (NTIS)

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61
Evaluation of the PAPNET cytologic screening system for quality control of cervical smears.
1994-02-01

The PAPNET system is an automated interactive instrument for analysis of conventional (Papanicolaou) cervical smears. The instrument, described in this paper, introduces several important innovations to cytology automation. The cell selection system is composed of two stages: an algorithmic classifier, followed by a trained neural network allowing for ...

PubMed

62
The clinical importance of atypical glandular cells of undetermined significance on the cytologic smear.
2000-11-01

The objective of the study was to assess the prevalence of underlying cervical and endometrial lesions among patients with atypical glandular cells of undetermined significance (AGCUS) on the cytologic smear. Eighty-six patients with AGCUS, without evidence of squamous intraepithelial lesions, underwent coloposcopy and endocervical curettage (ECC) within 6 ...

PubMed

63
Routine papillomavirus antigen staining of cervical punch biopsy specimens.
1987-10-01

Immunocytochemical staining for papillomavirus antigen was carried out on 1147 consecutive cervical punch biopsy specimens over 12 months. Of 876 cases with cervical intraepithelial neoplasia (CIN) 351, were antigen positive and of 49 cases with histological evidence of human papillomavirus (HPV) infection but no CIN, 14 were positive. There were 204 cases ...

PubMed Central

64
Human papillomavirus testing in the prevention of cervical cancer.
2011-01-31

Strong evidence now supports the adoption of cervical cancer prevention strategies that explicitly focus on persistent infection with the causal agent, human papillomavirus (HPV). To inform an evidence-based transition to a new public health approach for cervical cancer screening, we summarize the natural history and cervical ...

PubMed

65
Cofactors in human papillomavirus infection and cervical carcinogenesis.
2011-08-10

OBJECTIVE: This study aimed to identify the effect of various risk factors as the promoters of HPV infection, and to identify which HPV-positive women may have an increased risk of developing cervical cancer. METHODS: Smear preparations were examined and classified according to the Bethesda system. HPV-DNA detection and genotyping was carried out using polymerase chain ...

PubMed

66
Relation between sampling device and detection of abnormality in cervical smears: a meta-analysis of randomised and quasi-randomised studies.
1996-11-23

OBJECTIVE: To assess the diagnostic yield of different sampling devices used in cervical screening. DESIGN: Meta-analysis of randomised and quasi-randomised studies. SETTING: All randomised and quasi-randomised studies comparing the yield of cytological or histological abnormalities when two or more different sampling devices were ...

PubMed Central

67
Hybrid capture vs. PCR screening of cervical human papilloma virus infections. Cytological and histological associations in 1270 women
2010-02-22

BackgroundWe evaluated two molecular methods of HPV detection and their correlation with cytological and histological diagnosis in a large sample of Greek women.MethodsAll women with liquid-based cytology performed at a University Hospital between 2000 and 2003 were included. The Hybrid Capture 2 (HC2) kit and in house Polymerase Chain Reaction (PCR) were ...

PubMed Central

68
Human papillomavirus infection in women with and without cervical cancer in Tbilisi, Georgia.
2011-02-02

Background: No accurate estimates of cervical cancer incidence or mortality currently exist in Georgia. Nor are there any data on the population-based prevalence of high-risk (HR) human papillomavirus (HPV) infection, which, in the absence of good-quality screening, is known to correlate with cervical cancer incidence. Methods: We obtained ...

PubMed

69
HPV is detectable in virtually all abnormal cervical cytology samples after reinvestigation of HPV negatives with multiple alternative PCR tests.
2010-09-01

The demonstration of human papillomavirus (HPV) in 99.7% of cervical carcinoma surgical specimens from around the world required investigations by multiple alternative polymerase chain reaction (PCR) assays. A similar approach may therefore be necessary to best characterize HPV prevalence and genotype distribution among cervical ...

PubMed

70
The prevalence of abnormal cervical cytology in women with systemic lupus erythematosus.
2010-11-01

To compare the frequency of abnormal cervical cytology in women with systemic lupus erythematosus (SLE) with that of healthy women without connective tissue diseases by using ThinPrep� liquid based Pap Tests(TM). A retrospective case-control study over 2 years was conducted. The cases included all women with SLE who had Pap tests ...

PubMed

71
Screening for squamous cervical cancer: duration of low risk after negative results of cervical cytology and its implication for screening policies. IARC Working Group on evaluation of cervical cancer screening programmes.
1986-09-13

A collaborative study of screening programmes in eight countries was performed to estimate the risks of cervical cancer associated with different screening policies. Most of the data came from centrally organised screening programmes. Relative protection was higher in women who had had two or more negative results of screening tests than in those who had had only one negative ...

PubMed Central

72
Systemic lupus erythematosus, human papillomavirus infection, cervical pre-malignant and malignant lesions: a systematic review.
2010-10-31

The purpose of this study was to review and evaluate systematically the scientific evidence on the relationship between systemic lupus erythematosus (SLE), human papillomavirus (HPV) infection, pre-cancerous cervical abnormalities, and cervical cancer. Establishing strict inclusion and exclusion criteria, we performed an extensive ...

PubMed

73
Biopsy and selective recall compared with immediate large loop excision in management of women with low grade abnormal cervical cytology referred for colposcopy: multicentre randomised controlled trial
2009-07-28

Objectives To compare the effectiveness of punch biopsy and selective recall for treatment versus a policy of immediate treatment by large loop excision in the management of women with low grade abnormal cervical cytology referred for colposcopy.Design Multicentre individually randomised controlled trial, nested within the NHS ...

PubMed Central

74
[Atypical cervical cytology during pregnancy in the region of Baranja].

In the period from 1985 to 1989, 2521 pregnant women, making up 18.7% of women in fertile age, were controlled in antenatal surgeries in the area of Baranja. In 73 (2.9%) women a cytologic picture of cervical atypia was found: in 2.1% of them there was a cytologic picture of light and moderate dysplasia (group IIIA), in 0.6% a picture ...

PubMed

75
Optoelectronic method for detection of cervical intraepithelial neoplasia and cervical cancer
2011-12-01

The optoelectronic method is one of the most promising concepts of biophysical program of the diagnostics of CIN and cervical cancer. Objectives of the work are evaluation of sensitivity and specificity of the optoelectronic method in the detection of CIN and cervical cancer. The paper shows correlation between the pNOR number and sensitivity/specificity ...

NASA Astrophysics Data System (ADS)

76
CT of the normal and abnormal parametria in cervical cancer
1984-09-01

To evaluate CT criteria for differentiating a cervical cancer confined to the cervix from a lesion that invades the parametria, 16 patients with newly diagnosed, untreated cervical cancer were studied with CT. Twenty-five parameria were confined by radical hysterectomy, transvaginal parametrial fine-needle aspiration cytology, or ...

Energy Citations Database

77
What women want. Women's preferences for the management of low-grade abnormal cervical screening tests: a systematic review.
2011-09-01

Please cite this paper as: Frederiksen M, Lynge E, Rebolj M. What women want. Women's preferences for the management of low-grade abnormal cervical screening tests: a systematic review. BJOG 2011; DOI: 10.1111/j.1471-0528.2011.03130.x. Background? If human papillomavirus (HPV) testing will replace cytology in primary ...

PubMed

78
Histologic and clinical characteristics associated with rapidly progressive invasive cervical cancer: a preliminary report from the Yale Cancer Control Research Unit.

Histologic and clinical characteristics associated with rapidly progressive invasive cervical cancer are presented in this preliminary report from a population-based study involving all patients in Connecticut diagnosed with cervical cancer from March 1, 1985. Rapidly progressive invasive cervical cancer, i.e., invasive cancer ...

PubMed

79
Associations between Oral HPV16 Infection and Cytopathology: Evaluation of an Oropharyngeal "Pap-Test Equivalent" in High-Risk Populations.
2011-08-11

Human papillomavirus (HPV) is responsible for the rising incidence of oropharyngeal squamous cell cancers (OSCC) in the United States, and yet, no screening strategies have been evaluated. Secondary prevention by means of HPV detection and cervical cytology has led to a decline in cervical cancer incidence in the United States. Here, ...

PubMed

80
Spectral Cytopathology of Cervical Samples: Detecting Cellular Abnormalities in Cytologically Normal Cells
2010-04-05

AimSpectral Cytopathology (SCP) is a novel spectroscopic method for objective and unsupervised classification of individual exfoliated cells. The limitations of conventional cytopathology are well-recognized within the pathology community. In SCP, cellular differentiation is made by observing molecular changes in the nucleus and the cytoplasm, which may or may not produce morphological changes ...

PubMed Central

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81
European guidelines for quality assurance in cervical histopathology.
2011-02-11

The current paper presents Chapter 5 of the second edition of the European Guidelines for Quality Assurance in Cervical Cancer Screening, which deals with the histopathological diagnosis of lesions of the uterine cervix. It completes a series of publications in journals containing the contents of other parts of the European Guidelines. Histopathology provides the final ...

PubMed

82
HPV testing as a triage for borderline or mild dyskaryosis on cervical cytology: results from the Sentinel Sites study.
2011-09-06

Background:Earlier pilot studies of human papillomavirus (HPV) triage concluded that HPV triage was feasible and cost-effective. The aim of the present study was to study the impact of wider rollout of HPV triage for women with low-grade cytology on colposcopy referral and outcomes.Methods:Human papillomavirus testing of liquid-based cytology (LBC) samples ...

PubMed

83
Human papillomavirus prevalence in women attending routine cervical screening in South Wales, UK: a cross-sectional study
2008-10-28

In this cross-sectional population-based study we determine human papillomavirus (HPV) prevalence in South Wales to provide comprehensive baseline data for future assessment of the impact of prophylactic HPV vaccination and to help inform future screening strategies. Liquid-based cytology samples from women attending routine cervical screening were ...

PubMed Central

84
Primary screening for cervical cancer precursors by the combined use of liquid-based cytology, computer-assisted cytology and HPV DNA testing
2002-02-01

Primary screening for cervical cancer precursors has considerably evolved with the introduction of new technology to improve the early detection of disease. The objective of this study was to elaborate a diagnostic pathway integrating liquid-based and computer-assisted cytology and human papillomavirus DNA testing to focus screening on women at risk which ...

PubMed Central

85
Promising strategies for cervical cancer screening in the post-human papillomavirus vaccination era.
2010-09-01

Human papillomavirus (HPV) vaccination is expected to reduce the burden of cervical cancer in most settings; however, it is also expected to interfere with the effectiveness of screening. In the future, maintaining Pap cytology as the primary cervical screening test may become too costly. As the prevalence of ...

PubMed

86
Accuracy and Cost-Effectiveness of Cervical Cancer Screening by High-Risk HPV DNA Testing of Self-Collected Vaginal Samples
2010-07-01

ObjectiveEstimate the accuracy and cost-effectiveness of cervical cancer screening strategies based on high-risk HPV DNA testing of self-collected vaginal samples.Materials and MethodsA subset of 1,665 women (18-50 years of age) participating in a cervical cancer screening study were screened by liquid-based cytology and by high-risk ...

PubMed Central

87
Liquid-based cytology--new possibilities in the diagnosis of cervical lesions.
2010-03-01

Liquid-based cytology (LBC) enables the use of supplementary methods in the diagnosis and prognosis of cervical lesions. The aim of this study was to analyze the correlation between p16-INK4a immunoexpression in ThinPrep cervical cytologic samples and human papillomavirus (HPV) detection by polymerase chain ...

PubMed

88
Automatic recognition of abnormal cells in cytological tests using multispectral imaging
2010-03-01

Cervical cancer is the leading cause of gynecologic disease-related death worldwide, but is almost completely preventable with regular screening, for which cytological testing is a method of choice. Although such testing has radically lowered the death rate from cervical cancer, it is plagued by low sensitivity and inter-observer ...

NASA Astrophysics Data System (ADS)

89
Cervical cancer screening program of Paran�: cost-effective model in a developing country.
2003-07-01

The purpose of this study is to report the organization of a cost-effective screening program for cervical cancer in a developing country such as Brazil. The Cervical Cancer Screening Program of Paran� (CCSPP) was launched in October 1997 and was the result of a joint collaboration between the government of Paran� (Secretary of Health of the State of ...

PubMed

90
Colposcopy in special circumstances: Pregnancy, immunocompromise, including HIV and transplants, adolescence and menopause.
2011-08-16

The true value of colposcopy in pregnancy is under debate; the examination may be more difficult depending on the gestation at which a woman presents. Cervical intraepithelial neoplasia does not have an accelerated progression during pregnancy, and treatment is usually deferred until postpartum. The prevalence of cervical intraepithelial neoplasia is ...

PubMed

91
High long-term cure rate justifies routine treatment of cervical intraepithelial neoplasia grade I.
1995-05-01

The long-term clearance of cervical intraepithelial neoplasia (CIN) Grade 1 after one treatment was studied retrospectively in 105 patients. Treatment was by CO2 laser vaporization (74 patients), cone biopsy (8), loop electroexcision (LEEP) (7), electrodiathermy (1) and hysterectomy (2); 79 of the 92 treated patients (85.9%) had normal cervical ...

PubMed

92
Experience with high-risk human papillomavirus testing on vaginal brush-based self-samples of non-attendees of the cervical screening program.
2011-04-11

We evaluated the effect of offering brush-based vaginal self-sampling for high-risk human papillomavirus (hrHPV) testing to non-attendees of the cervical screening program on response rate, compliance to follow-up and cervical intraepithelial neoplasia grade 2 or 3 (CIN2+/CIN3+) yield. In addition, concordance of hrHPV test results between physician-taken ...

PubMed

93
Cervical cancer screening in Mediterranean countries: implications for the future.
2010-08-15

Prompted by feedback from the 34th European Congress of Cytology (ECC), the practice of including a special symposium in the programme was continued in the 35th ECC in Lisbon (2009) by arranging a satellite symposium entitled 'Cervical Cancer Screening in the Mediterranean Countries'. Because of the importance to the future of this discipline, it was felt ...

PubMed

94
Prevalence and cumulative incidence of abnormal cervical cytology among HIV-infected Thai women: a 5.5-year retrospective cohort study
2011-01-07

BackgroundCervical cancer is one of the most common AIDS-related malignancies in Thailand. To prevent cervical cancer, The US Public Health Service and The Infectious Disease Society of America have recommended that all HIV-infected women should obtain 2 Pap smears 6 months apart after the initial HIV diagnosis and, if results of both are normal, should ...

PubMed Central

95
Relation of Recent Tampon Use, Douching, Coitus, and Vaginal Medications for Reported Cervical Cytology Results.
1993-01-01

Health care references recommend avoiding tampons, douching, coitus, and vaginal medications prior to cervical cytology screening yet little research supports these recommendations. A descriptive correlational design was used to investigate tampon use pat...

National Technical Information Service (NTIS)

96
Internet-Based Cervical Cytology Screening System.
2007-01-01

This project explores the combination of computerized automated primary screening of cervical cytology specimens in remote sites with interpretation of device-selected images transmitted via the Internet. The project is in 3 phases: 1) hardware/software a...

National Technical Information Service (NTIS)

97
Internet-Based Cervical Cytology Screening Program.
2006-01-01

This project explores the combination of computerized automated primary screening of cervical cytology specimens in remote sites with interpretation of device-selected images transmitted via the Internet. The project is in 3 phases: (1) hardware/software ...

National Technical Information Service (NTIS)

98
Effectiveness of Cytologic Screening on Reducing Cervical Cancer Morbidity and Mortality. Part I.
1975-01-01

The impact of cervical cytologic screening on cancer morbidity and mortality is assessed. Emphasis is placed on methods for carrying out a screening program and for evaluating the impact of screening and on a plan for implementation in which operational a...

National Technical Information Service (NTIS)

99
A Pilot Study of Value of Information Analysis to Support Research

cytology screening for cervical cancer (LBC) � Beta interferon and glatiramer acetate in the management based cytology screening for cervical cancer (LBC) Beta interferon and glatiramer acetate macular degeneration 12 Chapter 3: Glycoprotein IIb/IIIa antagonists for the treatment of acute coronary

E-print Network

100
[Cervical cancer prevention: the impact of HPV vaccination].
2006-03-10

Cervical cancer remains a critical public health problem that is second only to breast cancer in overall disease burden for women throughout the world. In spite of the success of cervical cancer screening, Pap cytology screening is yet to be effectively implemented or has failed to reduce cervical cancer rates to ...

PubMed

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101
Concomitant infections with human papillomavirus and various mycoplasma and ureaplasma species in women with abnormal cervical cytology.
2011-09-22

Purpose: The objective of the present study is to verify possible association between infections with mycoplasmas and ureaplasmas and the presence of HPV infections in women diagnosed with abnormal cervical cytology.Material/Methods: The investigation included 387 non-pregnant women among whom: 62 were diagnosed with ASCUS, 167 with ...

PubMed

102
Comparison of the sensitivity of conventional cytology and the ThinPrep Imaging System for 1,083 biopsy confirmed high-grade squamous lesions.
2010-05-01

Liquid-based cytology continues to be utilized as an adjunct to conventional cytology in most Australian laboratories, even though a direct-to-vial ThinPrep protocol has been introduced in many countries with established cervical screening programs. Manual screening of ThinPrep slides has been widely practiced for more than 10 years ...

PubMed

103
The impact of human papillomavirus vaccination on cervical cancer prevention efforts
2009-05-01

ObjectivesTo review concepts, information, obstacles, and approaches to cervical cancer screening and prevention as vaccination against human papillomavirus (HPV) types 16 and 18 is adopted.MethodsExpert forum, conducted September 12�13, 2008, hosted by the Society of Gynecologic Oncologists, including 56 experts in cervical cancer and titled Future ...

PubMed Central

104
Are Muslim women less susceptible to oncogenic human papillomavirus infection? A study from rural eastern India.

Muslim women are known to have lower incidences of cervical cancer and/or human papillomavirus (HPV) infection. Here we aim to determine any association that may be present between the oncogenic HPV16/18 infections and abnormal cytological lesions along with demographic and other attributes among Indian Muslim women (n = 478) and ...

PubMed

105
Management guidelines for women with normal colposcopy after low grade cervical abnormalities: population study
2000-06-24

ObjectivesTo develop an evidence based protocol for the follow up of women with low grade cervical abnormalities for whom treatment is not immediately indicated.DesignPopulation outcome study.SettingColposcopy clinic of an inner city teaching hospital.Participants566 women with low grade cytological abnormalities ...

PubMed Central

106
Human papillomavirus (HPV) prevalence and types among Turkish women at a gynecology outpatient unit
2009-11-30

BackgroundHuman Papillomavirus (HPV) is a well-known pathogen for lower genital tract neoplasias, yet little is known regarding HPV prevalence in Turkey. The aim of this study was to investigate the prevalence of HPV DNA and to determine HPV types distribution among women with normal and abnormal cytology.MethodsA total of five hundred seven (n = 507) ...

PubMed Central

107
Pattern of epithelial cell abnormality in Pap smear: A clinicopathological and demographic correlation
2011-04-30

Background:In the low resource settings of a developing country, a conventional Papanicolaou (Pap) test is the mainstay screening system for cervical cancer. In order to counsel women and to organize a public health system for cervical cancer screening by Pap smear examination, it is imperative to know the pattern of premalignant and malignant lesions. ...

PubMed Central

108
Tobacco smoking and regression of low-grade cervical abnormalities.
2010-09-01

The role of tobacco smoking in the multistage carcinogenesis at the cervix is not fully understood because of a paucity of prospective data. To assess the relationship between smoking and spontaneous regression of cervical precursor lesions, a total of 516 women with low-grade squamous intraepithelial lesion (LSIL) were monitored by cytology and colposcopy ...

PubMed

109
Early integration of high copy HPV16 detectable in women with normal and low grade cervical cytology and histology
2006-05-01

BackgroundIntegration of human papillomavirus (HPV) DNA has been considered a late event in cervical carcinogenesis. However, integrated forms of HPV were recently detected in cancer precursor lesions using a new real time polymerase chain reaction (PCR) to detect the deletions at the 3362�3443 region of HPV16 E2ObjectiveTo study the frequency of HPV16 DNA integration in ...

PubMed Central

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