... and R. Maas. 1994. Msx1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development. Nature ... ...
NBII National Biological Information Infrastructure
This book contains the following 10 chapters: Introduction; The Human Hemoglobins; The Human Globin Genes; Hemoglobin Synthesis and Globin Gene Expression; The Globin Gene Mutations - A. Mechanisms and Classification; The Globin Gene Mutations - B. Their Phenotypes and Clinical ...
Energy Citations Database
Oxidative stress alters the expression of transcription factors in human lymphocytes. Given the critical role these factors play in gene regulation, their abnormal regulation should lead to disturbances in gene expression and these in turn will result in ...
National Technical Information Service (NTIS)
... Abnormalities affecting the INK4A locus are common in breast cancer; 2) Disregulation of expression of the genes encoded by such locus (pl6 and ...
DTIC Science & Technology
... 8q24.2 that encodes osteoprotegerin (OPG), a member of the tumor necrosis factor receptor family [5]. The primary pathologic abnormality in ...
... small portion of them play a causal role in cancer development. ... genomes of these materials for chromosomal and genetic abnormalities using PCR ...
... antibody, and fluorescein isothiocyanate-conjugated streptavidin, ... and B2). Note the greater number of hybridization signals in a part of an ... ...
Genomic imprinting is a parent of origin-dependent gene silencing that involves marking of alleles in the germline and differential expression in somatic cells of the offspring. Imprinted genes and abnormal imprinting have been implicated in development, ...
The relative mapping positions of genes for polypeptides expressed abnormally in tumors (tumor markers) and cellular proto-oncogenes were analyzed and a remarkable degree of co-mapping of tumor marker genes with oncogenes in the human karyotype were found...
Epigenetics indicates the heritable changes in gene expression without nucleotide sequence variation. Leukemogenesis is closely related to abnormal epigenetic regulation. MicroRNA is a non-coding microRNA which regulates the expression of target mRNAs at both transcriptional and translational levels. MicroRNA plays ...
PubMed
. The origins of chromosomal abnormalities and aneuploidy in cancer are the subject of debate (5). Opinions range from viewing aneuploidy as a central cause of tumor initiation (6�8) to regarding it as just of multiple genes. In a budding yeast study (30), aneuploidy has been linked with chromosome-wide gene
E-print Network
This application proposed to test two hypotheses. The first hypothesis to be tested in this was whether c-myb and A-myb genes regulate ductal cell proliferation and whether abnormalities in the expression of these genes results in breast cancer. Our studi...
The hypothesis to be tested in this application is whether c-myb and A-myb genes regulate ductal cell proliferation and whether abnormalities in the expression of these genes results in breast cancer. During the first year of this study, we constructed ta...
The aim of this project is to identify the molecular basis for the abnormal destruction of extracellular matrix that accompanies breast cancer. This is being addressed primarily by identifying the control elements within the genes of the matrix metallopro...
... Norma L. Hudson, and Kenneth P. McNattyAgResearch, Wallaceville Animal Research Centre, Upper Hutt, New Zealand 1Supported by New ... Science and Technology. 2Correspondence: Jennifer L. Juengel, Wal...
One of the most common molecular abnormalities in human cancers involves over-expression of the c-Myc oncoprotein. By regulating the expression of key cellular genes, c-Myc controls a number of normal biological properties such as cell cycle entry, differ...
To clarify whether expression of the programmed cell death 5 (PDCD5) gene in leukemic cells is abnormal, real-time quantitative reverse transcription polymerase chain reaction (RQ-RT-PCR) was used to examine its expression in marrow cells from leukemia patients. We found lower PDCD5 in both AML and CML marrow cells ...
Genomic imbalance is a common cause of phenotypic abnormalities. We measured the relative expression level of genes that map within the microdeletion that causes Williams-Beuren syndrome and within its flanking regions. We found, unexpectedly, that not only hemizygous genes but also normal-copy neighboring ...
PubMed Central
. "Our plans to further characterize behavior and gene expression in these animals will help us identify Lexicon Genetics Inc. of Texas. The work was funded by the National Institute of Diabetes and Digestive and gene expression in these animals will help us identify the target genes that are ...
We propose that the expression of several unknown genes is affected by gamma radiation. Abnormal expression of these genes may be one of the early steps in breast carcinogenesis induced by radiation. We plan to establish an assay that will allow us to scr...
We propose that the expression of several unknown genes is affected by gamma radiation. Abnormal expression of these genes may be one of the steps in breast carcinogenesis induced by radiation. We plan to establish an assay that will allow us to screen fo...
We propose that the expression of several unknown genes is affected by gamma radiation. Abnormal expression of these genes maybe one of the early steps in breast carcinogenesis induces by radiation. We plan to establish an assay that will allow us to scre...
The objective has been to compare genes which are expressed in specific cell types and isolate them by nucleic acid annealing methods; to provide a basis for understanding of abnormal growth of cells; and to provide a basis for rRNA gene amplifications, transcription, molecular organization, and regulation of ...
