Serial brain imaging in a patient with multiple sclerosis showed several definite but evanescent areas of abnormal accumulation of /sup 99m/Tc- pertechnetate. (auth)

Abnormalities in hematological indices are frequently encountered in cirrhosis. Multiple causes contribute to the occurrence of hematological abnormalities. Recent studies suggest that the presence of hematological cytopenias is associated with a poor prognosis in cirrhosis. The present article reviews the pathogenesis, incidence, ...

... Key words: Duplicate gallbladder; Hepatobiliary embryology; Multiple gallbladders; Gallbladder development; Gallbladder abnormalities ...

Sickle cell anemia is an inherited disorder in which abnormal hemoglobin (the red pigment inside red blood cells) is produced. The abnormal hemoglobin causes red blood ...

DiGeorge Syndrome; Shprintzen Syndrome; Chromosome Abnormalities; Abnormalities, Multiple; Conotruncal Cardiac Defects

To evaluate cases with unclassified multiple congenital abnormalities including microtia and anotia as component congenital abnormalities in order to reveal the characteristic pattern of other associated component congenital abnormalities and to make an attempt to establish a registry diagnosis on the pattern of ...

The 75-page report describes and analyzes the occurrences of multiple zones of abnormal formation pressure that were encountered in nine wells drilled in the Navarin basin. The report provides a discussion of the abnormal pressure response on wireline logs and drilling parameters, and a comparison between direct and indirect pressure ...

Protein abnormalities in 13 patients with multiple myeloma were studied by paper electrophoresis, immunoelectrophoresis, and immunoglobulin quantitation. Five patients had IgA myeloma, six had IgG myeloma, and two had hypoglobulinermic myeloma. These thre...

... When added to the growth medium of a mammalian cell line, it caused micronucleation, amitosis, and multiple cell division. ...

... the military departments and agencies for Research Development Test and ... probably develops as multiple genetic abnormalities accumulate, but ...

... Development of Alternative Fitting Procedures Using Spreadsheets ... and Selenium biological response: Chromosomal abnormalities in chronic ...

Nonselective Losses in Foveal Chromatic and Luminance Sensitivity in Multiple Sclerosis Dovid H in patients with multiple sclerosis (MS) and in matched normal controls. The patient group showed substantial function is frequently abnormal in demyelin- ating disease. In multiple sclerosis (MS) and recovered optic

The objective of this study was to evaluate the possible association of drug treatments in pregnant women with a higher risk of congenital abnormalities of the external ear, particularly microtia/anotia, in their children. The frequency of drug treatments was compared in the mothers of cases with isolated or multiple (syndromic) ear ...

Visual fields were examined with a tangent screen in 54 patients with multiple sclerosis (MS) or optic neuritis (ON). Visual fields were abnormal in all patients with definite MS, 94% with probable MS and 81% with possible MS. Three-quarters of the MS patients with no history of visual symptoms had abnormal fields. The commonest defect ...

Patients with multiple sclerosis commonly describe visual symptoms that result from several eye movement abnormalities that occur from disruption of critical pathways in the brainstem, cerebellum, and cerebral hemispheres. These abnormalities include internuclear ophthalmoplegia, ocular motor palsy, ocular misalignment, pathologic ...

Monkeys infected with the Asibi strain of yellow fever virus developed multiple coagulation abnormalities 3-4 days after viral inoculation. These coagulation abnormalities occurred almost simultaneously with the development of fever, clinical illness and ...

The cases are presented of two siblings with multiple cutaneous tumours associated with adenomatous polyps of the colon and bony abnormalities. In one patient an adenocarcinoma of the colon supervened, and there was a history of adenocarcinoma of the colon without the presence of other abnormalities in a third sibling. Clinically the ...

We report a case of incidental multiple focal uptakes of Tc-99m MDP in both the lungs without lung parenchymal abnormality. A 15-year-old girl who had no symptoms or history of pulmonary disorder was referred for Tc-99m MDP bone scintigraphy to evaluate temporomandibular joint disorders. Bone scintigraphy showed multiple focal uptakes ...

MRI examination of 41 patients with clinical definite multiple sclerosis showed white matter lesions of high proton T2 signal consistent with demyelination in 76% and CSF abnormalities present in 76%. Of patients with CSF abnormalities, 26% had normal MRI scans; conversely 26% of patients with MRI abnormalities had ...

... (7) the motion-defined letter test was used on 25 patients with multiple sclerosis and 50 controls; 34/50 eyes of patients were abnormal even though ...

Journal of Abnormal Psychology, 84,. 76-79. Damos, D. , and Bloem, K. (in press) . Type A behavior pattern, multiple-task performance, and subjective ...

Hemangioendothelioma is a very rare, locally invasive vascular tumor. Multiple abnormal radionuclide studies of brain, lungs, kidneys, liver, and spleen were observed in a patient with hemangioendotheliomatosis. (auth)

patients with primary amyloidosis respond to chemotherapy focused on the abnormal plasma cells. A stem cell transplant may be done, as in multiple myeloma. In secondary...

... b. serum protein abnormalities i. multiple myeloma ii. Waldenstromrs macroglobulinemia iii. pregnant women c. autoimmune hemolytic anemia d. oncology patients ...

Despite the constellation of abnormal genetic changes that drive multiple myeloma, these cancer cells are controlled by a single protein, researchers reported online in Nature this week.

... group with anasarca at external examination also had multiple visceral malformations which included partial cleft palate, abnormalities of the heart ...

Neuromyelitis optica (NMO) is a demyelinating disease consisting of relapsing-remitting optic neuritis and myelitis with a more severe course than Multiple Sclerosis. Recently, it has been shown that almost 50% of patients with NMO can have brain magnetic resonance imaging (MRI) abnormalities. We report on six Brazilian patients with NMO, fulfilling the ...

The mode of development of abnormalities of the interkinetic nuclei that are observed in irradiated cells is described. The genesis of these abnormalities, as studied in vitro in living erythroblasts of Tribon by cinemicrography, is attributed to arrest provoked by ioniziog radiations during different phases of karyokinesis, followed by ...

A case of multiple ileal duplications presenting with gastrointestinal bleeding is described. Technetium-99m Pertechnetate scintigraphy in conjunction with barium studies provided the initial clue and accurately localised the abnormality pre-operatively. PMID:2155086

The potential clinical importance of T1 and T2 relaxation times in distinguishing normal and pathologic tissue with magnetic resonance (MR) is discussed and clinical examples of cerebral abnormalities are given. Five patients with cerebral infarction, 15 with multiple sclerosis, two with Wilson disease, and four with tumors were imaged. Hemorrhagic and ...

The incidence of developmental abnormalities in domestic animals is low, however there is continuing pressure on the veterinarian to answer concerns of the producer as to why the abnormality occurred and what significance it has for the rest of the herd. Generally, both normal and abnormal development are products of both genetic and ...

Human chromosome disease arises from a change in the number or structure of one or more chromosomes. The multiple genes represented in the duplicated or deleted chromosomes are not usually defective and any systemic abnormalities can be attributed to a change in gene dosage. Banding techniques are now commonly used to identify each chromosome and the ...

Congenital abnormalities (CA) are deviations from the normal embryonic development that appear antenatal and they are characterized by the alteration of the morphology and function of an organ, system of organs or even of the entire body. MATERIAL AND METHOD: The study, on a period of eight years, included 1685 children with CA, from which 58% were males and 50% were from the ...

Tissue abnormality characterization is a generalized segmentation problem which aims at determining a continuous score that can be assigned to the tissue which characterizes the extent of tissue deterioration, with completely healthy tissue being one end of the spectrum and fully abnormal tissue such as lesions, being on the other end. Our method is based ...

Acute demyelinating optic neuritis in children can occur in isolation or be associated with acute disseminated encephalomyelitis, multiple sclerosis or neuromyelitis optica. Clinical features, neuroimaging, cerebrospinal fluid findings and long term prognosis were reviewed in 26 children diagnosed with optic neuritis at the first presentation of demyelinating disease. The risk ...

The cytogenetic findings in 11 patients with multiple myeloma in whom a myelodysplastic syndrome or an acute nonlymphocytic leukemia developed are reported. All patients were treated with oral melphalan for 2-9 years in a total dose of 0.5-4.1 g. When examined during the myelodysplastic or leukemic phase, all patients had an abnormal bone marrow karyotype, ...

The chromosome complements of 662 spermatozoa produced by the three fathers of individuals with Bloom syndrome (BS) were analyzed to determine whether the BS mutation could affect chromosome segregation and the frequency of aneuploidy in sperm. The frequency of numerical abnormalities was not significantly different from that in normal controls studied in our laboratory, but ...

A fibroblast culture was established from a lymph node biopsy of a patient with non-Hodgkin lymphoma, 9 months after chemotherapy and intensive therapeutic x-irradiation of the area. In contrast with blood and bone marrow, which were chromosomally normal, all cells of the lymph node were chromosomally abnormal, with numerous clones having multiple ...

Current strategies for detecting chromosome abnormalities in MDS/AML include FISH or traditional cytogenetics. MLPA detects abnormalities in multiple loci simultaneously, with higher resolution and throughput. Peripheral blood from 50 healthy subjects was used to establish probe-specific reference ranges, increasing MLPA sensitivity ...

The Havanese is a toy breed that presents with a wide range of developmental abnormalities. Skeletal defects, particularly osteochondrodysplasia (OCD), are the most frequently observed anomalies. Cataracts, liver shunts, heart murmurs, and missing incisors are also common in this breed. Estimates of heritability and complex segregation analyses were carried out to evaluate ...

We report a case of multiple abnormalities with eustachian tube obstruction by a protruded internal carotid artery. A 10-year-old male presented with multiple abnormalities including anomalous pinna, poor eyesight, facial palsy, moderate conductive deafness, and otitis media with effusion. Temporal bone computed ...

Two patients with multiple sclerosis are reported in whom psychopathological symptoms were present for many years. An exact psychiatric classification of the clinical syndrome was not possible. At no time during the illness were abnormal neurological findings observed. Multiple sclerosis was proven following necropsy in one patient. In ...

Failure to demonstrate abnormalities on diagnostic tests in patients felt certain to have a disease is all too common, especially when symptoms are mild to moderate. One strategy used in such cases is to perform multiple tests hoping that one will confirm the clinical suspicion. An example of this strategy is found in carpal tunnel syndrome where ...

The advantages of implementing diversity in the form of multiple neuro-agents has been demonstrated through numerical experiments. As expected, diagnostic performance was robust despite noise distortion and sensor faults. The results validate our claim that combining multiple and diverse perspectives is indeed beneficial for dependable diagnoses under ...

Among 23 women who underwent diagnostic hysteroscopy after triple uterine artery ligation with or without hemostatic multiple square suturing for the management of postpartum hemorrhage (PPH), five had abnormal findings. Endometritis was statistically significantly associated with abnormal diagnostic hysteroscopy findings. Twelve ...

Multiple development of eyes and cephalic tentacles was observed in developing embryos of the Atlantic oyster drill, Urosalpinx cinerea. These abnormalities were found in 2.7 percent of embryos previously exposed to 0.01 ppM mercuric chloride and in 0.4 percent of control animals. Animals were noted with one to three tentacles and one to six eyes. The most ...

Systemic lupus erythematosus (SLE) is an autoimmune disease resulting from a loss of tolerance to multiple self antigens, and characterized by autoantibody production and inflammatory cell infiltration in target organs, such as the kidneys and brain. T cells are critical players in SLE pathophysiology as they regulate B cell responses and also infiltrate target tissues, ...

Smith-Magenis syndrome (SMS) is a multiple congenital anomaly, mental retardation (MCA/MR) syndrome associated with deletion of chromosome 17 band p11.2. As part of a multi-disciplinary clinical, cytogenetic, and molecular approach to SMS, detailed clinical studies including radiographic neurologic, developmental, ophthalmologic, otolaryngologic, and audiologic evaluations ...

Numerical chromosome abnormalities were studied in single blastomeres from arrested or otherwise morphologically abnormal human preimplantation embryos. A 6-h FISH procedure with fluorochrome-labeled DNA probes was developed to determine numerical abnormalities of chromosomes X, Y, and 18. The three chromosomes were stained and ...

We describe three children with surgically confirmed meconium peritonitis. All had abnormal prenatal ultrasonographic examinations. The first child showed multiple cysts, the second had hydrops fetalis, and the third had dilated bowel loops. A polyhydramnion was common to all three cases. Of the two children who died, one had cystic fibrosis. It is ...

Until recently, clinical dysmorphology was poorly considered in medicine and human genetics. However, the studies of children affected with multiple congenital anomalies syndromes lead to syndrome identification, prognosis and care for the affected children, and genetic counselling for the families. The identification of developmental genes involved in normal and ...

Scintigraphy with Tc-99m-labeled red blood cells was used to evaluate five patients with suspected vascular abnormalities. The technique was useful for the imaging of large areas of the body and in obtaining multiple views. Conventional radionuclide angiography is of limited usefulness in such cases. PMID:6780666

Scintigraphy with Tc-99m-labeled red blood cells was used to evaluate five patients with suspected vascular abnormalities. The technique was useful for the imaging of large areas of the body and in obtaining multiple views. Conventional radionuclide angiography is of limited usefulness in such cases.

. The origins of chromosomal abnormalities and aneuploidy in cancer are the subject of debate (5). Opinions range from viewing aneuploidy as a central cause of tumor initiation (6�8) to regarding it as just of multiple genes. In a budding yeast study (30), aneuploidy has been linked with chromosome-wide gene

: hereditary pancreatitis multiple endocrine neoplasia type I syndrome hereditary nonpolyposis colon cancerPANCREATIC CANCER Pancreatic cancer is a disease in which cells become abnormal and multiply% of pancreatic cancers begin in exocrine cells. Cancers derived from the endocrine cells (pancreatic

In a recent study published in the journal Blood, researchers from the NCI have reported an association between obesity, African-American race, and a condition associated with an increased risk of multiple myeloma.� The condition, known as monoclonal gammopathy of undetermined significance, or MGUS, is marked by the presence of abnormal levels of a ...

We describe two sibs, one male and one female, presenting a new autosomal recessive multiple congenital anomalies/mental retardation syndrome of 'coarse face', microcephaly, moderate to severe mental retardation, epilepsy and skeletal abnormalities. PMID:8867658

This report describes previously unreported upper airway abnormalities encountered in a 5-month-old American miniature horse colt presented for elective surgery. Caution should be exercised when administering general anesthesia or heavy sedation to individuals of this breed that present with multiple congenital abnormalities.

To address inconsistencies among health care providers in breast cancer screening and management of abnormal findings, we randomized eight Family Practice residencies into control and intervention groups. The intervention has multiple components addressin...

A case of primary intestinal lymphangiectasia is presented in which multiple blind peroral jejunal biopsies were unable to document any abnormality, despite strongly suggestive clinical history and radiographic findings. Endoscopically directed biopsy was necessary to document the characteristic pathologic lesion. This report documents the importance of ...

Two tests of binaural hearing, namely intensity discrimination of alternating monaural clicks and interaural time difference (IATD) discrimination of binaural clicks, were performed in 28 patients with definite multiple sclerosis (MS) and 12 with an isolated brainstem lesion compatible with demyelination. Intensity discrimination defects were found in 53.5% and IATD defects in ...

The yellow nail syndrome was defined as a clinical entity in the 1960s. Although nail abnormalities were the first sign to be noticed, this syndrome is now known to involve multiple organ systems and its association with other diseases is well described. A review of the medical literature is provided.

A biologically active substance has been concentrated by chemical and physical fractionation from benthic marine algae. When added to the growth medium of a mammalian cell line, it caused micronucleation, amitosis, and multiple cell division. Following me...

Focal Dermal Hypoplasia (FDH), also known as Goltz syndrome (OMIM 305600), is a genetic disorder that affects multiple organ systems early in development. Features of FDH include skin abnormalities, (hypoplasia, atrophy, linear pigmentation, and herniation of fat through dermal defects); papillomas...

Researchers have found that women with scoliosis, or abnormal curvature of the spine, who were exposed to multiple diagnostic X-rays during childhood and adolescence may be at increased risk of dying of breast cancer

Contents: Hemoglobinopathies; Pulmonary changes in the sickle cell hemoglobinopathies; Thrombogenesis and heparin; Staging procedures in hodgkin's disease; Infectious complications of malignant disease; Protein abnormalities and treatment of multiple myel...

A 2-month old squirrel monkey (Saimiri sciureus) succumbed following a month of frequent petit mal seizures. At autopsy the only gross abnormality was a separation of the parietal suture line of the cranium. Hematoxylin and eosin stains revealed multiple ...

Jun 10, 2011 ... Dog-1 mutants show multiple genetic deletions as well as chromosomal abnormalities. Scientists compared space-flown normal and Dog-1 mutant ...

... abnormalities, such as small or missing teeth, weak enamel, multiple cavities, and early tooth loss. Other common ... recessive ; camptodactyly ; cell ; channel ; cleft palate ; dysarthria ; dysplasia ; enamel ; gap junctions ; gene ; hypotrichosis ; incidence ; keratoderma ; microcephaly ; microphthalmia ; ...

... cells also show abnormalities in their chromosomes. Normal human cells contain 46 chromosomes�pieces of DNA and protein that control cell growth and metabolism. One fairly common finding in myeloma cells is that ...

The continuous recording of hypotonic hemolysis (osmogram) and the multiple tube osmotic fragility test demonstrated excellent correlation in identification of normal and abnormal erythrocytic fragility. Although both procedures are based on the same prin...

We report a rare case of inadvertent reversal of the defibrillator shock coils during generator change which then resulted in both intermittent, recurrent "noise" on both the rate sensing and the shock electrogram leads and multiple inappropriate shocks. PMID:18307635

Disclosed are new methods comprising the use of in situ hybridization to detect abnormal nucleic acid sequence copy numbers in one or more genomes wherein repetitive sequences that bind to multiple loci in a reference chromosome spread are either substant...

... to cancers of the bone marrow (leukemia or Hodgkin's disease ). The results may detect the cause of anemia (too few red blood cells), abnormal white blood cells, or ... Idiopathic aplastic anemia Multiple myeloma Neuroblastoma Non- ...

multiple sclerosis, acoustic neuroma, or stroke. Abnormal results may also be due to: Brain injury Brain malformation Brain tumor Central pontine myelinolysis Speech disorders...

Target behaviors in animals that appear analogous to symptoms central to multiple disease processes were investigated. Startle augmentation, hyperactivity and hyperactive components of stereotypy as a function of age was investigated as follows: (1) contr...

Twenty-six patients with multiple myeloma and macroglobulinemia of Waldenstrom were studied clinically and immunologically with characterization of their paraproteins and normal immunoglobulins, as well as by in vitro culture of their peripheral lymphocyt...

Due to the accumulating evidence that suggests that numerous unhealthy conditions in the indoor environment are the result of abnormal growth of the filamentous fungi (mold) in and on building surfaces, it is necessary to accurately determine the organisms responsible for these m...